## Tue Feb 17 07:39:00 2026
## emapper-2.1.13
## /data/anaconda3/envs/eggnog-mapper/bin/emapper.py -i /data/result/bins/wyx/bins/HKD2_bin.100.fa -m mmseqs --output HKD2_bin.100 --output_dir /data/result/bins/wyx/eggqs50+/HKD2_bin.100 --itype genome --cpu 8 --override
##
#query	seed_ortholog	evalue	score	eggNOG_OGs	max_annot_lvl	COG_category	Description	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	PFAMs
HKD2_k127_10020518_3	1254432.SCE1572_22885	3.974e-87	299.0	COG1409@1|root,COG1409@2|Bacteria,1MXD6@1224|Proteobacteria,42WZF@68525|delta/epsilon subdivisions,2WTE8@28221|Deltaproteobacteria,2Z34X@29|Myxococcales	28221|Deltaproteobacteria	S	Calcineurin-like phosphoesterase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
HKD2_k127_10020518_4	448385.sce3806	3.767e-69	250.0	COG1262@1|root,COG1262@2|Bacteria,1MZ25@1224|Proteobacteria,434N1@68525|delta/epsilon subdivisions,2WYZF@28221|Deltaproteobacteria,2Z0ZV@29|Myxococcales	28221|Deltaproteobacteria	S	Sulfatase-modifying factor enzyme 1	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase
HKD2_k127_10020518_2	502025.Hoch_3706	3.761e-109	381.0	COG0508@1|root,COG0508@2|Bacteria,1MUGY@1224|Proteobacteria,42RDN@68525|delta/epsilon subdivisions,2WMR0@28221|Deltaproteobacteria,2YUAJ@29|Myxococcales	28221|Deltaproteobacteria	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	pdhC	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
HKD2_k127_10020518_1	1242864.D187_006055	2.192e-124	421.0	COG0022@1|root,COG0022@2|Bacteria,1R8KB@1224|Proteobacteria,42MBM@68525|delta/epsilon subdivisions,2WJKG@28221|Deltaproteobacteria,2YXF6@29|Myxococcales	28221|Deltaproteobacteria	C	Pyruvate dehydrogenase	pdhB	-	1.2.4.1	ko:K00162	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2753	Transket_pyr,Transketolase_C
HKD2_k127_10020518_0	448385.sce3800	1.113e-138	454.0	COG1071@1|root,COG1071@2|Bacteria,1MU5R@1224|Proteobacteria,42MHF@68525|delta/epsilon subdivisions,2WJ1R@28221|Deltaproteobacteria,2YUGD@29|Myxococcales	28221|Deltaproteobacteria	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	pdhA	-	1.2.4.1	ko:K00161	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
HKD2_k127_10024974_6	448385.sce2338	8.764e-19	95.0	COG1595@1|root,COG1595@2|Bacteria,1QRUX@1224|Proteobacteria,434VK@68525|delta/epsilon subdivisions,2WZ6Q@28221|Deltaproteobacteria,2Z1FT@29|Myxococcales	28221|Deltaproteobacteria	K	Sigma-70, region 4	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r4_2
HKD2_k127_10024974_5	1352941.M877_11480	4.887e-26	110.0	COG3118@1|root,COG3118@2|Bacteria,2IQ9T@201174|Actinobacteria	201174|Actinobacteria	O	belongs to the thioredoxin family	trxA2	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
HKD2_k127_10024974_0	1192034.CAP_1523	7.285e-249	813.0	COG0515@1|root,COG2909@1|root,COG0515@2|Bacteria,COG2909@2|Bacteria,1QA6R@1224|Proteobacteria,4393M@68525|delta/epsilon subdivisions,2X49J@28221|Deltaproteobacteria,2YYJG@29|Myxococcales	28221|Deltaproteobacteria	KLT	Family membership	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,Pkinase
HKD2_k127_10024974_4	926560.KE387027_gene603	4.824e-37	146.0	COG0406@1|root,COG0406@2|Bacteria	2|Bacteria	G	alpha-ribazole phosphatase activity	-	-	3.1.3.85,5.4.2.11,5.4.2.12	ko:K01834,ko:K15634,ko:K22306	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	His_Phos_1
HKD2_k127_10024974_2	448385.sce7618	1.083e-93	316.0	COG1708@1|root,COG1708@2|Bacteria,1NKZT@1224|Proteobacteria,430VC@68525|delta/epsilon subdivisions,2WVUS@28221|Deltaproteobacteria,2Z164@29|Myxococcales	28221|Deltaproteobacteria	S	Uncharacterised protein family (UPF0158)	-	-	-	-	-	-	-	-	-	-	-	-	UPF0158
HKD2_k127_10024974_1	290397.Adeh_3457	1.373e-179	574.0	COG0554@1|root,COG0554@2|Bacteria,1MUP7@1224|Proteobacteria,42M9Z@68525|delta/epsilon subdivisions,2WIYZ@28221|Deltaproteobacteria,2YU0Z@29|Myxococcales	28221|Deltaproteobacteria	F	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate	glpK	GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615	2.7.1.30	ko:K00864	ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626	-	R00847	RC00002,RC00017	ko00000,ko00001,ko01000,ko04147	-	-	-	FGGY_C,FGGY_N
HKD2_k127_10044691_3	1162668.LFE_0169	1.234e-13	73.0	COG1180@1|root,COG1180@2|Bacteria,3J11T@40117|Nitrospirae	40117|Nitrospirae	C	Radical SAM superfamily	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Radical_SAM
HKD2_k127_10044691_1	1192034.CAP_2162	3.183e-77	267.0	COG1180@1|root,COG1180@2|Bacteria,1NQC1@1224|Proteobacteria,42MDS@68525|delta/epsilon subdivisions,2WJM3@28221|Deltaproteobacteria,2YTXA@29|Myxococcales	28221|Deltaproteobacteria	C	Elongator protein 3, MiaB family, Radical SAM	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Radical_SAM
HKD2_k127_10044691_2	314345.SPV1_08136	1.038e-40	167.0	COG2078@1|root,COG2078@2|Bacteria,1RJP4@1224|Proteobacteria	1224|Proteobacteria	S	PFAM AMMECR1 domain protein	-	-	-	ko:K09141	-	-	-	-	ko00000	-	-	-	AMMECR1
HKD2_k127_10044691_0	1454004.AW11_01260	5.993e-79	271.0	COG1355@1|root,COG1355@2|Bacteria,1MXK5@1224|Proteobacteria,2VKXP@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Belongs to the MEMO1 family	-	-	-	ko:K06990	-	-	-	-	ko00000,ko04812	-	-	-	AMMECR1,Memo
HKD2_k127_10046961_3	1380393.JHVP01000010_gene2893	1.617e-12	70.0	COG5002@1|root,COG5002@2|Bacteria,2I2DU@201174|Actinobacteria,4ESBG@85013|Frankiales	201174|Actinobacteria	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	2.7.13.3	ko:K02484	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
HKD2_k127_10046961_0	448385.sce1355	3.851e-280	886.0	COG0642@1|root,COG2205@2|Bacteria,1MUZQ@1224|Proteobacteria,42NZF@68525|delta/epsilon subdivisions,2WJNR@28221|Deltaproteobacteria,2YYGK@29|Myxococcales	28221|Deltaproteobacteria	T	Osmosensitive K+ channel His kinase sensor domain	kdpD	-	2.7.13.3	ko:K07646	ko02020,map02020	M00454	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	DUF4118,GAF_3,HATPase_c,HisKA,KdpD,Usp
HKD2_k127_10046961_2	1254432.SCE1572_09230	2.014e-92	308.0	COG0745@1|root,COG0745@2|Bacteria,1MWZ5@1224|Proteobacteria,42QTM@68525|delta/epsilon subdivisions,2WN5R@28221|Deltaproteobacteria,2YXCH@29|Myxococcales	28221|Deltaproteobacteria	K	Transcriptional regulatory protein, C terminal	kdpE	-	-	ko:K07667	ko02020,ko02024,map02020,map02024	M00454	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
HKD2_k127_10046961_4	1192034.CAP_5301	2.857e-11	76.0	COG4969@1|root,COG4969@2|Bacteria,1R0CQ@1224|Proteobacteria,43CV8@68525|delta/epsilon subdivisions,2X835@28221|Deltaproteobacteria,2Z3JW@29|Myxococcales	28221|Deltaproteobacteria	NU	Prokaryotic N-terminal methylation motif	-	-	-	ko:K02650	ko02020,map02020	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.15.2	-	-	N_methyl
HKD2_k127_10046961_1	1254432.SCE1572_10005	2.511e-157	497.0	COG0022@1|root,COG0022@2|Bacteria,1R8KB@1224|Proteobacteria,42N06@68525|delta/epsilon subdivisions,2WK5N@28221|Deltaproteobacteria,2YTX4@29|Myxococcales	28221|Deltaproteobacteria	C	Transketolase, pyrimidine binding domain	bkdB	-	1.2.4.1,1.2.4.4	ko:K00162,ko:K00167	ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00036,M00307	R00014,R00209,R01699,R03270,R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00004,RC00027,RC00627,RC02742,RC02743,RC02744,RC02882,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
HKD2_k127_10113504_4	1254432.SCE1572_35330	1.057e-41	154.0	2CDR8@1|root,32ZSF@2|Bacteria,1NCBG@1224|Proteobacteria,42V4S@68525|delta/epsilon subdivisions,2WSDP@28221|Deltaproteobacteria,2YVN6@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_10113504_3	1192034.CAP_0033	2.474e-83	293.0	COG0564@1|root,COG0564@2|Bacteria,1MUBN@1224|Proteobacteria,42MBA@68525|delta/epsilon subdivisions,2WKX9@28221|Deltaproteobacteria,2YUWE@29|Myxococcales	28221|Deltaproteobacteria	J	Responsible for synthesis of pseudouridine from uracil	rluD	-	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
HKD2_k127_10113504_2	1192034.CAP_0036	1.775e-98	338.0	COG0392@1|root,COG0392@2|Bacteria,1R4IS@1224|Proteobacteria,42WRK@68525|delta/epsilon subdivisions,2WSAB@28221|Deltaproteobacteria,2Z0VY@29|Myxococcales	28221|Deltaproteobacteria	S	Lysylphosphatidylglycerol synthase TM region	-	-	-	-	-	-	-	-	-	-	-	-	LPG_synthase_TM
HKD2_k127_10113504_1	1123242.JH636435_gene1216	1.819e-101	342.0	COG0714@1|root,COG0714@2|Bacteria,2IWZM@203682|Planctomycetes	203682|Planctomycetes	S	associated with various cellular activities	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
HKD2_k127_10113504_0	448385.sce5926	1.311e-188	599.0	COG3930@1|root,COG3930@2|Bacteria,1PYFH@1224|Proteobacteria,42ZAK@68525|delta/epsilon subdivisions,2WUH8@28221|Deltaproteobacteria,2YUXI@29|Myxococcales	28221|Deltaproteobacteria	S	DUF1704	-	-	-	-	-	-	-	-	-	-	-	-	DUF1704,FGase
HKD2_k127_10113504_5	1192034.CAP_0669	6.36e-09	67.0	COG2133@1|root,COG2133@2|Bacteria	2|Bacteria	G	pyrroloquinoline quinone binding	-	-	-	-	-	-	-	-	-	-	-	-	Big_5,F5_F8_type_C,PA14,Phosphoesterase
HKD2_k127_10113504_6	1192034.CAP_3914	8.86e-06	48.0	COG0823@1|root,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	-	-	-	-	-	-	-	-	-	-	DUF4214,HYR,PD40,PKD,REJ
HKD2_k127_10128258_3	1254432.SCE1572_23570	3.391e-36	140.0	COG2018@1|root,COG2018@2|Bacteria,1NG1T@1224|Proteobacteria,42VP4@68525|delta/epsilon subdivisions,2WS9A@28221|Deltaproteobacteria,2YVP4@29|Myxococcales	28221|Deltaproteobacteria	S	Roadblock/LC7 domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_10128258_2	582402.Hbal_1900	4.092e-39	151.0	COG0757@1|root,COG0757@2|Bacteria,1RDDT@1224|Proteobacteria,2U9BV@28211|Alphaproteobacteria,43XV0@69657|Hyphomonadaceae	28211|Alphaproteobacteria	E	Catalyzes a trans-dehydration via an enolate intermediate	aroQ	-	4.2.1.10	ko:K03786	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03084	RC00848	ko00000,ko00001,ko00002,ko01000	-	-	-	DHquinase_II
HKD2_k127_10128258_1	1192034.CAP_7020	4.963e-41	156.0	COG0511@1|root,COG0511@2|Bacteria,1RCXA@1224|Proteobacteria,42SQQ@68525|delta/epsilon subdivisions,2WPIW@28221|Deltaproteobacteria,2YVEU@29|Myxococcales	28221|Deltaproteobacteria	I	first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA	accB	-	-	ko:K02160	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742	RC00040,RC00367	ko00000,ko00001,ko00002	-	-	-	Biotin_lipoyl
HKD2_k127_10128258_0	1192034.CAP_7019	1.064e-104	345.0	COG0439@1|root,COG0439@2|Bacteria,1MU4H@1224|Proteobacteria,42M14@68525|delta/epsilon subdivisions,2WIN7@28221|Deltaproteobacteria,2YUJ1@29|Myxococcales	28221|Deltaproteobacteria	I	Biotin carboxylase	accC	-	6.3.4.14,6.4.1.1,6.4.1.2	ko:K01959,ko:K01961	ko00020,ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko01230,map00020,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212,map01230	M00082,M00173,M00376,M00620	R00344,R00742,R04385	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
HKD2_k127_10168893_0	1125863.JAFN01000001_gene1739	4.555e-203	639.0	COG1960@1|root,COG1960@2|Bacteria,1R6R2@1224|Proteobacteria,42NTR@68525|delta/epsilon subdivisions,2WKRA@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	acyl-coa dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HKD2_k127_10168893_5	448385.sce7410	7.874e-29	124.0	COG0724@1|root,COG0724@2|Bacteria,1N6VR@1224|Proteobacteria,43A9U@68525|delta/epsilon subdivisions,2X244@28221|Deltaproteobacteria,2Z171@29|Myxococcales	28221|Deltaproteobacteria	S	Pfam:RRM_6	-	-	-	-	-	-	-	-	-	-	-	-	RRM_1
HKD2_k127_10168893_1	861299.J421_0838	2.661e-165	534.0	COG0446@1|root,COG2146@1|root,COG0446@2|Bacteria,COG2146@2|Bacteria,1ZV6A@142182|Gemmatimonadetes	142182|Gemmatimonadetes	P	Pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2
HKD2_k127_10168893_2	1254432.SCE1572_00355	2.736e-79	284.0	COG1167@1|root,COG1167@2|Bacteria,1MV6F@1224|Proteobacteria,42MCR@68525|delta/epsilon subdivisions,2WJXI@28221|Deltaproteobacteria,2YY6G@29|Myxococcales	28221|Deltaproteobacteria	EK	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs	lysN	-	-	ko:K05825	ko00300,ko01100,ko01130,ko01210,map00300,map01100,map01130,map01210	-	R01939	RC00006	ko00000,ko00001,ko01000	-	-	-	Aminotran_1_2
HKD2_k127_10168893_4	448385.sce7477	4.316e-33	146.0	COG5592@1|root,COG5592@2|Bacteria,1ND3D@1224|Proteobacteria,42WES@68525|delta/epsilon subdivisions,2WSA6@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Hemerythrin HHE cation binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
HKD2_k127_10168893_3	290397.Adeh_4099	4.682e-41	154.0	COG0221@1|root,COG0221@2|Bacteria,1R5G5@1224|Proteobacteria,43833@68525|delta/epsilon subdivisions,2X3D2@28221|Deltaproteobacteria,2YVH7@29|Myxococcales	28221|Deltaproteobacteria	C	Inorganic pyrophosphatase	-	-	3.6.1.1	ko:K01507	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyrophosphatase
HKD2_k127_10178839_1	290397.Adeh_0440	2.88e-58	222.0	COG0577@1|root,COG0577@2|Bacteria,1P00G@1224|Proteobacteria,42P0D@68525|delta/epsilon subdivisions,2X7MP@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	FtsX-like permease family	-	-	-	-	-	-	-	-	-	-	-	-	FtsX
HKD2_k127_10178839_0	1254432.SCE1572_04205	3.074e-90	306.0	COG0767@1|root,COG0767@2|Bacteria,1RHNJ@1224|Proteobacteria,42SNW@68525|delta/epsilon subdivisions,2WPKT@28221|Deltaproteobacteria,2YV5J@29|Myxococcales	28221|Deltaproteobacteria	Q	ABC transporter permease	-	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE
HKD2_k127_10178839_2	1254432.SCE1572_04210	1.977e-41	158.0	2ENGZ@1|root,33G4G@2|Bacteria,1P6A6@1224|Proteobacteria,43288@68525|delta/epsilon subdivisions,2WXAP@28221|Deltaproteobacteria,2YVQY@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_10178839_3	987059.RBXJA2T_10464	6.4e-08	63.0	COG0215@1|root,COG0215@2|Bacteria,1MV8H@1224|Proteobacteria,2VHN4@28216|Betaproteobacteria,1KJN4@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	-	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e,tRNA-synt_1g
HKD2_k127_10198270_1	391625.PPSIR1_18075	1.26e-41	156.0	COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,42MER@68525|delta/epsilon subdivisions,2WIYV@28221|Deltaproteobacteria,2YW7P@29|Myxococcales	28221|Deltaproteobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding	-	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
HKD2_k127_10198270_0	1192034.CAP_4260	3.161e-89	310.0	COG1319@1|root,COG1319@2|Bacteria,1PG5C@1224|Proteobacteria,43EJH@68525|delta/epsilon subdivisions,2X9UI@28221|Deltaproteobacteria,2Z2GS@29|Myxococcales	28221|Deltaproteobacteria	C	CO dehydrogenase flavoprotein C-terminal domain	-	-	1.2.5.3	ko:K03519	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
HKD2_k127_10200101_0	1254432.SCE1572_42315	6.449e-301	946.0	COG0457@1|root,COG0515@1|root,COG1262@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG1262@2|Bacteria,1Q53R@1224|Proteobacteria,430W1@68525|delta/epsilon subdivisions,2WVP7@28221|Deltaproteobacteria,2YWDG@29|Myxococcales	28221|Deltaproteobacteria	KLT	Sulfatase-modifying factor enzyme 1	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	FGE-sulfatase,Pkinase
HKD2_k127_10200101_1	215803.DB30_8498	3.876e-165	526.0	COG2170@1|root,COG2170@2|Bacteria,1MX4N@1224|Proteobacteria,42SNZ@68525|delta/epsilon subdivisions,2X43E@28221|Deltaproteobacteria,2YY5K@29|Myxococcales	28221|Deltaproteobacteria	H	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity	-	-	-	ko:K06048	-	-	-	-	ko00000,ko01000	-	-	-	GCS2
HKD2_k127_1026656_0	1254432.SCE1572_42855	5.041e-125	421.0	COG1131@1|root,COG1131@2|Bacteria,1MY19@1224|Proteobacteria,43479@68525|delta/epsilon subdivisions,2X1TN@28221|Deltaproteobacteria,2YUXA@29|Myxococcales	28221|Deltaproteobacteria	V	ABC transporter, ATP-binding protein	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD2_k127_1030567_5	1254432.SCE1572_29345	1.104e-06	50.0	COG3291@1|root,COG3291@2|Bacteria	2|Bacteria	S	metallopeptidase activity	-	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	CBM60,CHU_C,Glyco_hydro_8,IgGFc_binding,PA14,PKD,PQQ,PQQ_2,fn3
HKD2_k127_1030567_2	1192034.CAP_2185	5.938e-46	177.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	HYR,HtaA,Neocarzinostat
HKD2_k127_1030567_3	448385.sce6264	1.124e-33	147.0	COG4775@1|root,COG4775@2|Bacteria	2|Bacteria	M	membrane organization	-	-	-	-	-	-	-	-	-	-	-	-	Bac_surface_Ag,CarboxypepD_reg,Laminin_G_3,POTRA
HKD2_k127_1030567_1	1220534.B655_1034	6.951e-53	201.0	COG1032@1|root,arCOG01356@2157|Archaea	2157|Archaea	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
HKD2_k127_1036390_0	378806.STAUR_8051	3.387e-146	478.0	COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,42M7F@68525|delta/epsilon subdivisions,2WIMF@28221|Deltaproteobacteria,2YYX2@29|Myxococcales	28221|Deltaproteobacteria	NU	Type II/IV secretion system protein	-	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
HKD2_k127_1036390_2	215803.DB30_1991	8.526e-05	56.0	2AGCS@1|root,316IF@2|Bacteria,1PXN9@1224|Proteobacteria,43EI7@68525|delta/epsilon subdivisions,2WZ12@28221|Deltaproteobacteria,2Z139@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1036390_1	1192034.CAP_7272	2.102e-42	166.0	COG2981@1|root,COG2981@2|Bacteria	2|Bacteria	E	high-affinity sulfate:proton symporter activity	cysZ	GO:0000096,GO:0000097,GO:0000103,GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006082,GO:0006520,GO:0006534,GO:0006790,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0008150,GO:0008152,GO:0008271,GO:0008272,GO:0008324,GO:0008509,GO:0008512,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009675,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015103,GO:0015116,GO:0015291,GO:0015293,GO:0015294,GO:0015295,GO:0015296,GO:0015318,GO:0015672,GO:0015698,GO:0016020,GO:0016021,GO:0016053,GO:0019344,GO:0019752,GO:0022804,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0034220,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044425,GO:0044459,GO:0044464,GO:0046394,GO:0051179,GO:0051234,GO:0055085,GO:0071704,GO:0071944,GO:0072348,GO:0098655,GO:0098656,GO:0098660,GO:0098661,GO:0098662,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901682,GO:1902358,GO:1902600	-	ko:K06203	-	-	-	-	ko00000	-	-	iJR904.b2413,iYL1228.KPN_02760	EI24
HKD2_k127_104236_5	1297742.A176_06152	9.347e-71	252.0	COG3243@1|root,COG3243@2|Bacteria,1MU68@1224|Proteobacteria,42MW8@68525|delta/epsilon subdivisions,2WKI6@28221|Deltaproteobacteria,2YY45@29|Myxococcales	28221|Deltaproteobacteria	I	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus	phaC	-	-	ko:K03821	ko00650,map00650	-	R04254	RC00004	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1
HKD2_k127_104236_0	502025.Hoch_0475	5.537e-203	651.0	COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,42N2G@68525|delta/epsilon subdivisions,2WIXB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	PFAM AMP-dependent synthetase and ligase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
HKD2_k127_104236_9	1278073.MYSTI_06549	2.518e-50	205.0	2AIV6@1|root,319CD@2|Bacteria,1Q2BD@1224|Proteobacteria,437XV@68525|delta/epsilon subdivisions,2X37S@28221|Deltaproteobacteria,2YUR7@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_104236_12	867845.KI911784_gene503	9.305e-37	156.0	COG2267@1|root,COG2267@2|Bacteria,2G6KF@200795|Chloroflexi,377MK@32061|Chloroflexia	32061|Chloroflexia	I	PFAM alpha beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_4
HKD2_k127_104236_11	502025.Hoch_0476	2.441e-37	146.0	COG5394@1|root,COG5394@2|Bacteria,1RHRC@1224|Proteobacteria,42WB9@68525|delta/epsilon subdivisions,2WQ0S@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM PHA accumulation regulator DNA-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	PHB_acc_N
HKD2_k127_104236_1	1125863.JAFN01000001_gene1249	3.211e-147	477.0	COG0133@1|root,COG0133@2|Bacteria,1MUS8@1224|Proteobacteria,42MIA@68525|delta/epsilon subdivisions,2WJJA@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB	-	4.2.1.20	ko:K01696,ko:K06001	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HKD2_k127_104236_8	243231.GSU2371	2.726e-57	216.0	COG0159@1|root,COG0159@2|Bacteria,1MXJV@1224|Proteobacteria,42N5B@68525|delta/epsilon subdivisions,2WJX4@28221|Deltaproteobacteria,43TZG@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate	trpA	-	4.2.1.20	ko:K01695	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_syntA
HKD2_k127_104236_4	1254432.SCE1572_10995	2.493e-75	259.0	COG0639@1|root,COG0639@2|Bacteria	2|Bacteria	T	phosphoprotein phosphatase activity	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos_2
HKD2_k127_104236_14	552811.Dehly_0503	1.092e-21	103.0	COG5580@1|root,COG5580@2|Bacteria	2|Bacteria	O	Activator of Hsp90 ATPase	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
HKD2_k127_104236_2	448385.sce3861	1.24e-113	384.0	COG0457@1|root,COG0789@1|root,COG0457@2|Bacteria,COG0789@2|Bacteria,1PQD2@1224|Proteobacteria,4323R@68525|delta/epsilon subdivisions,2WXJB@28221|Deltaproteobacteria,2Z10C@29|Myxococcales	28221|Deltaproteobacteria	K	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	MerR_1,TPR_1,TPR_17,TPR_8
HKD2_k127_104236_6	326427.Cagg_0668	4.929e-59	222.0	COG5184@1|root,COG5184@2|Bacteria,2G8WU@200795|Chloroflexi,3765G@32061|Chloroflexia	200795|Chloroflexi	DZ	PFAM regulator of chromosome condensation, RCC1	-	-	-	-	-	-	-	-	-	-	-	-	RCC1,RCC1_2
HKD2_k127_104236_10	290397.Adeh_3956	5.696e-49	183.0	2A9VF@1|root,30Z3B@2|Bacteria,1PKZS@1224|Proteobacteria,435JG@68525|delta/epsilon subdivisions,2WZXJ@28221|Deltaproteobacteria,2Z0YG@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_104236_15	1254432.SCE1572_35760	3.416e-06	59.0	COG2133@1|root,COG2133@2|Bacteria	2|Bacteria	G	pyrroloquinoline quinone binding	-	-	-	-	-	-	-	-	-	-	-	-	Big_5,F5_F8_type_C,PA14,Phosphoesterase
HKD2_k127_104236_3	1192034.CAP_3400	1.804e-91	318.0	COG0388@1|root,COG0388@2|Bacteria,1MUUB@1224|Proteobacteria,42T24@68525|delta/epsilon subdivisions,2WPF8@28221|Deltaproteobacteria,2YV09@29|Myxococcales	28221|Deltaproteobacteria	S	PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase	-	-	-	ko:K11206	-	-	-	-	ko00000,ko01000	-	-	-	CN_hydrolase
HKD2_k127_104236_7	1521187.JPIM01000001_gene852	6.048e-58	210.0	COG0807@1|root,COG0807@2|Bacteria,2G8P3@200795|Chloroflexi	200795|Chloroflexi	H	Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate	-	-	-	-	-	-	-	-	-	-	-	-	GTP_cyclohydro2
HKD2_k127_104236_13	1254432.SCE1572_23630	2.128e-23	104.0	2CIY5@1|root,2ZET1@2|Bacteria,1P8MM@1224|Proteobacteria,4330I@68525|delta/epsilon subdivisions,2WXKY@28221|Deltaproteobacteria,2YW19@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1044015_3	1192034.CAP_1612	4.241e-13	69.0	COG1716@1|root,COG2114@1|root,COG2203@1|root,COG1716@2|Bacteria,COG2114@2|Bacteria,COG2203@2|Bacteria,1RAHZ@1224|Proteobacteria,42UGY@68525|delta/epsilon subdivisions,2WQPI@28221|Deltaproteobacteria,2YUG9@29|Myxococcales	28221|Deltaproteobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	FHA,GAF,GAF_2,Guanylate_cyc
HKD2_k127_1044015_4	253839.SSNG_00513	3.169e-05	57.0	COG1572@1|root,COG2931@1|root,COG1572@2|Bacteria,COG2931@2|Bacteria,2GKNI@201174|Actinobacteria	201174|Actinobacteria	Q	Domain of unknown function (DUF5122) beta-propeller	-	-	-	-	-	-	-	-	-	-	-	-	DUF11,DUF5122
HKD2_k127_1044015_2	290397.Adeh_0971	2.288e-30	136.0	COG3837@1|root,COG3837@2|Bacteria,1N15Q@1224|Proteobacteria	1224|Proteobacteria	S	PFAM Cupin 2, conserved barrel domain protein	manC	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HKD2_k127_1044015_0	1192034.CAP_1611	7.335e-134	433.0	COG0825@1|root,COG0825@2|Bacteria,1MURN@1224|Proteobacteria,42NC2@68525|delta/epsilon subdivisions,2WKA3@28221|Deltaproteobacteria,2YU4X@29|Myxococcales	28221|Deltaproteobacteria	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA	accA	-	2.1.3.15,6.4.1.2	ko:K01962,ko:K01963	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	ACCA
HKD2_k127_1044015_1	1254432.SCE1572_17445	9.054e-80	269.0	COG0755@1|root,COG0755@2|Bacteria,1MU61@1224|Proteobacteria,42RU4@68525|delta/epsilon subdivisions,2WNN7@28221|Deltaproteobacteria,2YVGN@29|Myxococcales	28221|Deltaproteobacteria	O	Cytochrome C assembly protein	ccmC	-	-	ko:K02195	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.107	-	-	Cytochrom_C_asm
HKD2_k127_1075912_0	448385.sce0516	9.265e-146	475.0	COG0642@1|root,COG2205@2|Bacteria,1P4WV@1224|Proteobacteria,43ARK@68525|delta/epsilon subdivisions,2X65I@28221|Deltaproteobacteria,2YWWX@29|Myxococcales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
HKD2_k127_1075912_1	448385.sce2406	7.042e-94	317.0	COG0724@1|root,COG0724@2|Bacteria,1N6VR@1224|Proteobacteria	1224|Proteobacteria	S	PFAM RNP-1 like RNA-binding protein	rbpA	-	-	-	-	-	-	-	-	-	-	-	RRM_1
HKD2_k127_1075912_3	1254432.SCE1572_50715	7.695e-17	94.0	COG1520@1|root,COG1520@2|Bacteria,1P31B@1224|Proteobacteria,42VDF@68525|delta/epsilon subdivisions,2WRBJ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	SBBP,fn3
HKD2_k127_1075912_2	1254432.SCE1572_14530	8.23e-21	92.0	COG0267@1|root,COG0267@2|Bacteria,1NJ67@1224|Proteobacteria,42V5X@68525|delta/epsilon subdivisions,2WSIR@28221|Deltaproteobacteria,2YW1P@29|Myxococcales	28221|Deltaproteobacteria	J	Belongs to the bacterial ribosomal protein bL33 family	rpmG	-	-	ko:K02913	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L33
HKD2_k127_109589_1	357808.RoseRS_4194	4.12e-55	204.0	COG2110@1|root,COG2110@2|Bacteria,2G7ID@200795|Chloroflexi,377AT@32061|Chloroflexia	32061|Chloroflexia	F	PFAM Appr-1-p processing domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Macro
HKD2_k127_109589_0	1125863.JAFN01000001_gene3117	5.458e-60	216.0	COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,42MEQ@68525|delta/epsilon subdivisions,2WIPF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	PFAM glycosyl transferase, family 35	glgP	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	DUF3417,Phosphorylase
HKD2_k127_1115375_0	448385.sce2448	1.134e-88	295.0	COG1509@1|root,COG1509@2|Bacteria,1R8HT@1224|Proteobacteria,43DMX@68525|delta/epsilon subdivisions,2X6DS@28221|Deltaproteobacteria,2YUSV@29|Myxococcales	28221|Deltaproteobacteria	E	lysine 2,3-aminomutase	kamA1	-	5.4.3.2	ko:K01843	ko00310,map00310	-	R00461	RC00303	ko00000,ko00001,ko01000	-	-	-	LAM_C
HKD2_k127_1115375_3	448385.sce8300	7.154e-32	133.0	2C8AY@1|root,331RE@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1115375_1	1192034.CAP_6838	1.012e-70	254.0	COG2304@1|root,COG2304@2|Bacteria,1MW8K@1224|Proteobacteria,42Z9H@68525|delta/epsilon subdivisions,2WUIK@28221|Deltaproteobacteria,2YUAX@29|Myxococcales	28221|Deltaproteobacteria	K	protein containing a von Willebrand factor type A (vWA) domain	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VIT,VWA_3
HKD2_k127_1198671_0	1192034.CAP_3359	7.695e-105	351.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,42MK4@68525|delta/epsilon subdivisions,2WJJ8@28221|Deltaproteobacteria,2YWE1@29|Myxococcales	28221|Deltaproteobacteria	G	Tripartite ATP-independent periplasmic transporter, DctM component	-	-	-	-	-	-	-	-	-	-	-	-	DctM,DctQ
HKD2_k127_1198671_1	1192034.CAP_4553	7.486e-102	349.0	COG1638@1|root,COG1638@2|Bacteria,1PJFW@1224|Proteobacteria,42PXK@68525|delta/epsilon subdivisions,2WJFU@28221|Deltaproteobacteria,2Z1WI@29|Myxococcales	28221|Deltaproteobacteria	G	Bacterial extracellular solute-binding protein, family 7	-	-	-	-	-	-	-	-	-	-	-	-	DctP
HKD2_k127_1198671_3	1192034.CAP_3361	7.011e-41	154.0	COG5660@1|root,2Z7TM@2|Bacteria,1PMCV@1224|Proteobacteria,42Q81@68525|delta/epsilon subdivisions,2WIJ3@28221|Deltaproteobacteria,2Z2J1@29|Myxococcales	28221|Deltaproteobacteria	S	TRAP transporter T-component	-	-	-	-	-	-	-	-	-	-	-	-	TAtT
HKD2_k127_1216572_0	483219.LILAB_35175	7.013e-257	804.0	COG2993@1|root,COG3278@1|root,COG2993@2|Bacteria,COG3278@2|Bacteria,1MU18@1224|Proteobacteria,42M5M@68525|delta/epsilon subdivisions,2WM27@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Belongs to the heme-copper respiratory oxidase family	-	-	1.9.3.1	ko:K00404,ko:K15862	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	COX1,FixO
HKD2_k127_1216572_1	1379270.AUXF01000007_gene897	1.237e-23	104.0	COG2010@1|root,COG2010@2|Bacteria,1ZU6E@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	ko:K00406	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002	3.D.4.3	-	-	Cytochrome_CBB3,FixP_N
HKD2_k127_123449_6	1192034.CAP_0267	3.247e-10	64.0	COG0515@1|root,COG3899@1|root,COG0515@2|Bacteria,COG3899@2|Bacteria,1MWVZ@1224|Proteobacteria,438G1@68525|delta/epsilon subdivisions,2X3QZ@28221|Deltaproteobacteria,2YWVV@29|Myxococcales	28221|Deltaproteobacteria	KLT	Serine Threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	AAA_16,PEGA,Pkinase,TPR_12
HKD2_k127_123449_4	448385.sce0856	2.137e-84	302.0	COG0484@1|root,COG2206@1|root,COG0484@2|Bacteria,COG2206@2|Bacteria,1QX6J@1224|Proteobacteria,43BZ5@68525|delta/epsilon subdivisions,2X79W@28221|Deltaproteobacteria,2Z3EH@29|Myxococcales	28221|Deltaproteobacteria	O	DnaJ molecular chaperone homology domain	-	-	-	-	-	-	-	-	-	-	-	-	DnaJ
HKD2_k127_123449_2	483219.LILAB_11205	4.58e-121	398.0	COG0435@1|root,COG0435@2|Bacteria,1MV50@1224|Proteobacteria,42QMU@68525|delta/epsilon subdivisions,2WM9W@28221|Deltaproteobacteria,2YWBT@29|Myxococcales	28221|Deltaproteobacteria	O	Glutathione S-transferase, C-terminal domain	-	-	1.8.5.7	ko:K07393	-	-	-	-	ko00000,ko01000	-	-	-	GST_C_2,GST_N_2
HKD2_k127_123449_1	316067.Geob_0379	9.361e-170	560.0	COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,42MKU@68525|delta/epsilon subdivisions,2WJR3@28221|Deltaproteobacteria,43T7Y@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	PFAM UvrD REP helicase	pcrA	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
HKD2_k127_123449_3	1192034.CAP_8861	9.283e-94	324.0	COG2890@1|root,COG2890@2|Bacteria,1MXCQ@1224|Proteobacteria,42PKA@68525|delta/epsilon subdivisions,2WNH0@28221|Deltaproteobacteria,2YVC9@29|Myxococcales	28221|Deltaproteobacteria	J	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif	prmC	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0016740,GO:0016741,GO:0018364,GO:0019538,GO:0032259,GO:0036009,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0140096,GO:1901564	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS,Methyltransf_31
HKD2_k127_123449_5	448385.sce8057	6.915e-72	246.0	COG1109@1|root,COG1109@2|Bacteria,1MUA5@1224|Proteobacteria,42MET@68525|delta/epsilon subdivisions,2WITH@28221|Deltaproteobacteria,2YUC2@29|Myxococcales	28221|Deltaproteobacteria	G	Phosphoglucomutase/phosphomannomutase, C-terminal domain	algC	-	5.4.2.2,5.4.2.8	ko:K01840,ko:K15778	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
HKD2_k127_1241530_1	1254432.SCE1572_43940	1.969e-56	209.0	28T75@1|root,2ZFFV@2|Bacteria,1RBYB@1224|Proteobacteria,43DNG@68525|delta/epsilon subdivisions,2X6JU@28221|Deltaproteobacteria,2Z10T@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1241530_0	1254432.SCE1572_38850	1.24e-120	412.0	COG0564@1|root,COG1092@1|root,COG0564@2|Bacteria,COG1092@2|Bacteria,1PUHQ@1224|Proteobacteria,42Q87@68525|delta/epsilon subdivisions,2WPIN@28221|Deltaproteobacteria,2Z02J@29|Myxococcales	28221|Deltaproteobacteria	J	Belongs to the methyltransferase superfamily	-	-	2.1.1.191	ko:K06969	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_SAM,PseudoU_synth_2
HKD2_k127_1241530_2	448385.sce0220	9.056e-32	133.0	COG0515@1|root,COG0515@2|Bacteria	448385.sce0220|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_127287_0	448385.sce8461	4.382e-81	285.0	COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria	1224|Proteobacteria	C	Belongs to the peptidase M16 family	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
HKD2_k127_127287_1	1121382.JQKG01000005_gene3300	6.602e-22	108.0	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_6
HKD2_k127_127287_2	66875.JODY01000016_gene898	1.301e-17	85.0	COG1309@1|root,COG1309@2|Bacteria,2GNBI@201174|Actinobacteria	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C,TetR_N
HKD2_k127_1288281_7	1192034.CAP_5783	1.564e-11	65.0	COG3118@1|root,COG3118@2|Bacteria,1MZBB@1224|Proteobacteria,42TPU@68525|delta/epsilon subdivisions,2WQ1M@28221|Deltaproteobacteria,2YVHU@29|Myxococcales	28221|Deltaproteobacteria	O	Belongs to the thioredoxin family	trxA	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
HKD2_k127_1288281_5	1114964.L485_05950	2.248e-24	117.0	COG0628@1|root,COG0628@2|Bacteria,1MVX7@1224|Proteobacteria,2TVGG@28211|Alphaproteobacteria,2K0BX@204457|Sphingomonadales	204457|Sphingomonadales	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
HKD2_k127_1288281_2	864565.HMPREF0379_1496	4.293e-75	258.0	COG1136@1|root,COG1136@2|Bacteria,1TQC9@1239|Firmicutes,248Z6@186801|Clostridia	186801|Clostridia	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD2_k127_1288281_0	502025.Hoch_0325	1.219e-207	676.0	COG0577@1|root,COG0577@2|Bacteria,1MW6D@1224|Proteobacteria,42PQC@68525|delta/epsilon subdivisions,2WJ8K@28221|Deltaproteobacteria,2YY7H@29|Myxococcales	28221|Deltaproteobacteria	V	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HKD2_k127_1288281_1	502025.Hoch_0326	1.375e-85	320.0	COG0845@1|root,COG0845@2|Bacteria,1PZST@1224|Proteobacteria,42R2S@68525|delta/epsilon subdivisions,2WMVJ@28221|Deltaproteobacteria,2Z0BJ@29|Myxococcales	28221|Deltaproteobacteria	M	TIGRFAM efflux transporter, RND family, MFP subunit	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	HlyD_3
HKD2_k127_1288281_3	378806.STAUR_0197	2.709e-54	198.0	COG0639@1|root,COG0639@2|Bacteria	2|Bacteria	T	phosphoprotein phosphatase activity	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos_2
HKD2_k127_1288281_8	1211815.CBYP010000051_gene721	0.0005346	44.0	COG0312@1|root,COG0312@2|Bacteria,2GZPS@201174|Actinobacteria,4ES19@85013|Frankiales	201174|Actinobacteria	S	Putative modulator of DNA gyrase	-	-	-	-	-	-	-	-	-	-	-	-	PmbA_TldD
HKD2_k127_1288314_1	1430440.MGMSRv2_2189	5.818e-53	205.0	28HUW@1|root,2Z81F@2|Bacteria,1Q3QA@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1288314_0	344747.PM8797T_07137	1.358e-221	710.0	COG1680@1|root,COG3876@1|root,COG1680@2|Bacteria,COG3876@2|Bacteria,2IXF2@203682|Planctomycetes	203682|Planctomycetes	V	beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase,DUF1343
HKD2_k127_129642_9	1121935.AQXX01000121_gene5552	2.655e-26	127.0	COG0451@1|root,COG0451@2|Bacteria,1MW32@1224|Proteobacteria,1SYQK@1236|Gammaproteobacteria,1XR4N@135619|Oceanospirillales	135619|Oceanospirillales	M	NmrA-like family	-	-	1.1.1.219	ko:K00091	-	-	-	-	ko00000,ko01000	-	-	-	Epimerase
HKD2_k127_129642_0	1192034.CAP_1523	1.09e-205	684.0	COG0515@1|root,COG2909@1|root,COG0515@2|Bacteria,COG2909@2|Bacteria,1QA6R@1224|Proteobacteria,4393M@68525|delta/epsilon subdivisions,2X49J@28221|Deltaproteobacteria,2YYJG@29|Myxococcales	28221|Deltaproteobacteria	KLT	Family membership	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,Pkinase
HKD2_k127_129642_1	1278073.MYSTI_03555	2.61e-149	484.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2X7H1@28221|Deltaproteobacteria,2Z3GB@29|Myxococcales	28221|Deltaproteobacteria	K	Forkhead associated domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Sigma54_activat,Yop-YscD_cpl
HKD2_k127_129642_4	1173027.Mic7113_1036	3.146e-75	269.0	COG1819@1|root,COG1819@2|Bacteria,1G036@1117|Cyanobacteria,1H8RN@1150|Oscillatoriales	1117|Cyanobacteria	CG	UDP-glucoronosyl and UDP-glucosyl transferase	-	-	2.4.1.173	ko:K05841	-	-	-	-	ko00000,ko01000,ko01003	-	GT1	-	Glyco_transf_28,UDPGT
HKD2_k127_129642_3	215803.DB30_8360	4.323e-121	418.0	COG3185@1|root,COG3185@2|Bacteria,1MUVZ@1224|Proteobacteria,42R5V@68525|delta/epsilon subdivisions,2WMYF@28221|Deltaproteobacteria,2YZ86@29|Myxococcales	28221|Deltaproteobacteria	C	Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal	hppD	-	1.13.11.27	ko:K00457	ko00130,ko00350,ko00360,ko01100,map00130,map00350,map00360,map01100	M00044	R01372,R02521	RC00505,RC00738	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Glyoxalase,Glyoxalase_5
HKD2_k127_129642_2	1267535.KB906767_gene335	2.946e-123	404.0	COG3508@1|root,COG3508@2|Bacteria,3Y38R@57723|Acidobacteria	57723|Acidobacteria	Q	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate	hmgA	-	1.13.11.5	ko:K00451	ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120	M00044	R02519	RC00737	ko00000,ko00001,ko00002,ko01000	-	-	-	HgmA
HKD2_k127_129642_6	483219.LILAB_08450	6.027e-66	235.0	COG3055@1|root,COG4447@1|root,COG3055@2|Bacteria,COG4447@2|Bacteria,1P49S@1224|Proteobacteria,4350R@68525|delta/epsilon subdivisions,2WZBJ@28221|Deltaproteobacteria,2Z1SD@29|Myxococcales	28221|Deltaproteobacteria	S	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_129642_8	448385.sce5637	4.781e-42	174.0	COG1729@1|root,COG1729@2|Bacteria	2|Bacteria	S	protein trimerization	cpoB	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_6,TolA_bind_tri
HKD2_k127_129642_5	1254432.SCE1572_32035	1.236e-66	247.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,42MVV@68525|delta/epsilon subdivisions,2X4JB@28221|Deltaproteobacteria,2YZ4I@29|Myxococcales	28221|Deltaproteobacteria	KLT	Family membership	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HKD2_k127_129642_7	1278073.MYSTI_06065	8.379e-66	240.0	COG0583@1|root,COG0583@2|Bacteria,1MZTA@1224|Proteobacteria	1224|Proteobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HKD2_k127_1302696_4	1254432.SCE1572_17995	3.367e-26	109.0	COG1651@1|root,COG1651@2|Bacteria,1RKYF@1224|Proteobacteria,42T64@68525|delta/epsilon subdivisions,2WP82@28221|Deltaproteobacteria,2YU4W@29|Myxococcales	28221|Deltaproteobacteria	O	Thioredoxin	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_4
HKD2_k127_1302696_1	1444711.CCJF01000005_gene546	1.514e-141	478.0	COG1404@1|root,COG3391@1|root,COG1404@2|Bacteria,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Big_5,Calx-beta,SBBP
HKD2_k127_1302696_2	448385.sce5308	1.948e-135	449.0	COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,42MGZ@68525|delta/epsilon subdivisions,2WIY6@28221|Deltaproteobacteria,2YU9C@29|Myxococcales	28221|Deltaproteobacteria	L	DbpA RNA binding domain	-	-	3.6.4.13	ko:K05592	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019	-	-	-	DEAD,DbpA,Helicase_C
HKD2_k127_1302696_0	1121422.AUMW01000056_gene42	1.23e-215	690.0	COG2132@1|root,COG2132@2|Bacteria,1TQSU@1239|Firmicutes,24CJP@186801|Clostridia,260KE@186807|Peptococcaceae	186801|Clostridia	Q	Multicopper oxidase	-	-	1.16.3.3	ko:K06324	-	-	-	-	ko00000,ko01000	-	-	-	Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3
HKD2_k127_1302696_3	903814.ELI_4422	8.768e-54	206.0	2CE4Q@1|root,2Z7WX@2|Bacteria,1V1JQ@1239|Firmicutes,24G4E@186801|Clostridia,25W12@186806|Eubacteriaceae	186801|Clostridia	S	Arylsulfotransferase (ASST)	-	-	-	-	-	-	-	-	-	-	-	-	Arylsulfotran_2,Arylsulfotrans
HKD2_k127_1304057_0	1192034.CAP_1813	1.269e-61	221.0	COG0670@1|root,COG0670@2|Bacteria,1MU69@1224|Proteobacteria,42MWD@68525|delta/epsilon subdivisions,2WMG9@28221|Deltaproteobacteria,2YYK1@29|Myxococcales	28221|Deltaproteobacteria	S	Belongs to the BI1 family	ybhL	-	-	ko:K06890,ko:K19416	-	M00742	-	-	ko00000,ko00002,ko02000	1.A.14.2.1	-	-	Bax1-I
HKD2_k127_1304057_1	1254432.SCE1572_42020	6.611e-52	199.0	COG0308@1|root,COG0308@2|Bacteria,1NJK3@1224|Proteobacteria,42Y4Q@68525|delta/epsilon subdivisions,2WTET@28221|Deltaproteobacteria,2YVW2@29|Myxococcales	28221|Deltaproteobacteria	E	aminopeptidase N	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_MA_2
HKD2_k127_1304057_2	1121866.AUGK01000007_gene293	9.981e-21	95.0	COG0607@1|root,COG0607@2|Bacteria,2HV5N@201174|Actinobacteria,4CWCQ@84998|Coriobacteriia	84998|Coriobacteriia	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
HKD2_k127_1304057_3	448385.sce4032	6.438e-19	91.0	COG2304@1|root,COG2304@2|Bacteria,1PBY8@1224|Proteobacteria,4386F@68525|delta/epsilon subdivisions,2X3GC@28221|Deltaproteobacteria,2YVZ2@29|Myxococcales	28221|Deltaproteobacteria	S	von Willebrand factor (vWF) type A domain	cglB	-	-	-	-	-	-	-	-	-	-	-	VWA
HKD2_k127_1305751_0	1254432.SCE1572_02920	3.508e-143	466.0	COG0699@1|root,COG0699@2|Bacteria,1MXBK@1224|Proteobacteria,42PVB@68525|delta/epsilon subdivisions,2WIMK@28221|Deltaproteobacteria,2YZ8C@29|Myxococcales	28221|Deltaproteobacteria	S	Dynamin family	-	-	-	-	-	-	-	-	-	-	-	-	Dynamin_N
HKD2_k127_1305751_1	1192034.CAP_8388	2.241e-70	249.0	COG2334@1|root,COG2334@2|Bacteria,1MUKJ@1224|Proteobacteria,42X9G@68525|delta/epsilon subdivisions,2WSQS@28221|Deltaproteobacteria,2YV88@29|Myxococcales	28221|Deltaproteobacteria	F	Belongs to the pseudomonas-type ThrB family	thrB	-	2.7.1.39	ko:K02204	ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230	M00018	R01771	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	APH
HKD2_k127_1305751_4	448385.sce1752	1.695e-41	157.0	COG0735@1|root,COG0735@2|Bacteria,1N0HW@1224|Proteobacteria,42TU6@68525|delta/epsilon subdivisions,2WPZ1@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	Belongs to the Fur family	-	-	-	ko:K03711,ko:K09825	-	-	-	-	ko00000,ko03000	-	-	-	FUR
HKD2_k127_1305751_3	448385.sce1753	6.793e-48	178.0	COG1592@1|root,COG1592@2|Bacteria,1R9WG@1224|Proteobacteria,42N9V@68525|delta/epsilon subdivisions,2WJWQ@28221|Deltaproteobacteria,2YV2V@29|Myxococcales	28221|Deltaproteobacteria	C	Rubrerythrin	rbr	GO:0003674,GO:0005488,GO:0005506,GO:0043167,GO:0043169,GO:0046872,GO:0046914	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
HKD2_k127_1307513_0	448385.sce9161	1.577e-235	774.0	COG0515@1|root,COG3899@1|root,COG0515@2|Bacteria,COG3899@2|Bacteria,1Q4QW@1224|Proteobacteria,4388X@68525|delta/epsilon subdivisions,2X3II@28221|Deltaproteobacteria,2YW8D@29|Myxococcales	28221|Deltaproteobacteria	KLT	AAA ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,Pkinase
HKD2_k127_1307513_8	269482.Bcep1808_6125	4.588e-07	55.0	2CKZ2@1|root,33FGI@2|Bacteria,1NN5C@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1307513_1	1242864.D187_007124	2.158e-195	623.0	COG0137@1|root,COG0137@2|Bacteria,1MV0Y@1224|Proteobacteria,42N81@68525|delta/epsilon subdivisions,2WJB0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Belongs to the argininosuccinate synthase family. Type 1 subfamily	argG	GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Arginosuc_synth
HKD2_k127_1307513_2	1242864.D187_007254	3.645e-125	416.0	COG0165@1|root,COG0165@2|Bacteria,1MUTU@1224|Proteobacteria,42M7Y@68525|delta/epsilon subdivisions,2WIRN@28221|Deltaproteobacteria,2YV9Y@29|Myxococcales	28221|Deltaproteobacteria	E	argininosuccinate lyase	argH	GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.3.2.1	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01086	RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ASL_C2,Lyase_1,NUDIX
HKD2_k127_1307513_4	316067.Geob_1123	9.564e-85	292.0	COG0078@1|root,COG0078@2|Bacteria,1MUFM@1224|Proteobacteria,42M0Q@68525|delta/epsilon subdivisions,2WJ3G@28221|Deltaproteobacteria,43TZK@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline	argF	GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.1.3.3,2.1.3.9	ko:K00611,ko:K09065	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01398,R07245	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
HKD2_k127_1307513_7	1174528.JH992898_gene3434	6.79e-15	86.0	COG0271@1|root,COG0271@2|Bacteria,1G7V3@1117|Cyanobacteria,1JM5S@1189|Stigonemataceae	1117|Cyanobacteria	T	BolA-like protein	colA	-	-	-	-	-	-	-	-	-	-	-	BolA
HKD2_k127_1307513_3	448385.sce4512	1.363e-95	329.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,42MVV@68525|delta/epsilon subdivisions,2X4JB@28221|Deltaproteobacteria,2YZ4I@29|Myxococcales	28221|Deltaproteobacteria	KLT	Family membership	-	-	2.7.11.1	ko:K08884	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HKD2_k127_1307513_5	448385.sce6026	3.312e-50	191.0	COG0457@1|root,COG0457@2|Bacteria	448385.sce6026|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1307513_9	1254432.SCE1572_00790	1.592e-05	58.0	COG3391@1|root,COG3391@2|Bacteria,1Q2JN@1224|Proteobacteria,4386H@68525|delta/epsilon subdivisions,2X9ZH@28221|Deltaproteobacteria,2YVZH@29|Myxococcales	28221|Deltaproteobacteria	S	Beta-L-arabinofuranosidase, GH127	-	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3,Stig1
HKD2_k127_1307513_6	1242864.D187_005568	6.084e-33	127.0	COG1028@1|root,COG1028@2|Bacteria,1MUBQ@1224|Proteobacteria,42S4I@68525|delta/epsilon subdivisions,2WNXV@28221|Deltaproteobacteria,2YUF1@29|Myxococcales	28221|Deltaproteobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	fabG3	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HKD2_k127_1309865_0	1254432.SCE1572_25675	6.757e-94	319.0	COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,42MKB@68525|delta/epsilon subdivisions,2WJ4W@28221|Deltaproteobacteria,2YUFE@29|Myxococcales	28221|Deltaproteobacteria	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
HKD2_k127_1310757_0	1254432.SCE1572_07650	6.772e-194	617.0	COG1024@1|root,COG1024@2|Bacteria,1N817@1224|Proteobacteria,4388N@68525|delta/epsilon subdivisions,2XA2D@28221|Deltaproteobacteria,2YW7N@29|Myxococcales	28221|Deltaproteobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	4.1.2.44	ko:K15513	ko00362,map00362	-	R09556	RC03426	ko00000,ko00001,ko01000	-	-	-	ECH_1
HKD2_k127_1310757_2	1122604.JONR01000010_gene3952	1.565e-17	93.0	COG0727@1|root,COG0727@2|Bacteria,1RG0N@1224|Proteobacteria,1SQVH@1236|Gammaproteobacteria,1XANN@135614|Xanthomonadales	135614|Xanthomonadales	S	Putative zinc- or iron-chelating domain	-	-	-	-	-	-	-	-	-	-	-	-	CxxCxxCC
HKD2_k127_1310757_1	452652.KSE_65750	9.602e-18	98.0	COG3831@1|root,COG3831@2|Bacteria,2HIEQ@201174|Actinobacteria,2M4DS@2063|Kitasatospora	201174|Actinobacteria	S	Proposed nucleic acid binding domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4132,WGR
HKD2_k127_1321167_1	1408424.JHYI01000020_gene4535	3.406e-84	292.0	COG0593@1|root,COG0593@2|Bacteria,1TPV7@1239|Firmicutes,4H9MW@91061|Bacilli,1ZBKI@1386|Bacillus	91061|Bacilli	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids	dnaA	GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0034641,GO:0034645,GO:0042802,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901576,GO:1990837	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA,Bac_DnaA_C,DnaA_N
HKD2_k127_1321167_2	1192034.CAP_3132	8.195e-58	213.0	294S9@1|root,2ZS5H@2|Bacteria,1P6YX@1224|Proteobacteria,4330Z@68525|delta/epsilon subdivisions,2WY8M@28221|Deltaproteobacteria,2YZRX@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1321167_3	448385.sce9366	2.668e-44	170.0	COG4445@1|root,COG4445@2|Bacteria,1MVFE@1224|Proteobacteria,439JD@68525|delta/epsilon subdivisions,2X4VZ@28221|Deltaproteobacteria,2YZQ9@29|Myxococcales	28221|Deltaproteobacteria	FJ	tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE)	-	-	-	ko:K06169	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	MiaE
HKD2_k127_1321167_5	1192034.CAP_5360	2.115e-33	145.0	COG0824@1|root,COG0824@2|Bacteria,1MZH6@1224|Proteobacteria,42U6U@68525|delta/epsilon subdivisions,2WQS4@28221|Deltaproteobacteria,2YVQM@29|Myxococcales	28221|Deltaproteobacteria	S	Thioesterase-like superfamily	-	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT,4HBT_2
HKD2_k127_1321167_0	448385.sce8175	3.854e-222	722.0	COG4932@1|root,COG4932@2|Bacteria,1PF83@1224|Proteobacteria,430QE@68525|delta/epsilon subdivisions,2WVYF@28221|Deltaproteobacteria,2Z1TZ@29|Myxococcales	28221|Deltaproteobacteria	M	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
HKD2_k127_1321167_6	1254432.SCE1572_42265	3.685e-26	126.0	COG2304@1|root,COG2304@2|Bacteria,1PBY8@1224|Proteobacteria,4386F@68525|delta/epsilon subdivisions,2X3GC@28221|Deltaproteobacteria,2YVZ2@29|Myxococcales	28221|Deltaproteobacteria	S	von Willebrand factor (vWF) type A domain	cglB	-	-	-	-	-	-	-	-	-	-	-	VWA
HKD2_k127_1326193_15	1192034.CAP_2145	5.591e-56	197.0	COG0631@1|root,COG0631@2|Bacteria,1R7UF@1224|Proteobacteria,42QUA@68525|delta/epsilon subdivisions,2WMWM@28221|Deltaproteobacteria,2YU7P@29|Myxococcales	28221|Deltaproteobacteria	T	Protein serine threonine phosphatase	pph1	-	3.1.3.16	ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C_2
HKD2_k127_1326193_14	1545915.JROG01000003_gene1614	6.676e-63	232.0	COG0477@1|root,COG0477@2|Bacteria,1MXZ3@1224|Proteobacteria,2TSHC@28211|Alphaproteobacteria,2K0UX@204457|Sphingomonadales	204457|Sphingomonadales	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
HKD2_k127_1326193_11	448385.sce7897	2.652e-66	239.0	COG1595@1|root,COG1595@2|Bacteria,1MX7T@1224|Proteobacteria,42U04@68525|delta/epsilon subdivisions,2WQA9@28221|Deltaproteobacteria,2YVKS@29|Myxococcales	28221|Deltaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD2_k127_1326193_10	1254432.SCE1572_35595	6.57e-76	262.0	COG1968@1|root,COG1968@2|Bacteria,1MX02@1224|Proteobacteria,42N67@68525|delta/epsilon subdivisions,2WKPK@28221|Deltaproteobacteria,2Z316@29|Myxococcales	28221|Deltaproteobacteria	V	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin	uppP	-	3.6.1.27	ko:K06153	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	BacA
HKD2_k127_1326193_17	502025.Hoch_6741	1.156e-33	144.0	2ABYR@1|root,311G5@2|Bacteria,1RD0Z@1224|Proteobacteria,42S20@68525|delta/epsilon subdivisions,2WNAC@28221|Deltaproteobacteria,2YW4B@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1326193_16	448385.sce4710	1.008e-38	153.0	COG0494@1|root,COG0494@2|Bacteria,1QXXS@1224|Proteobacteria,43C8Y@68525|delta/epsilon subdivisions,2X7JB@28221|Deltaproteobacteria,2YVVN@29|Myxococcales	28221|Deltaproteobacteria	L	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
HKD2_k127_1326193_19	195105.CN97_14830	3.499e-07	59.0	COG1846@1|root,COG1846@2|Bacteria,1RJPG@1224|Proteobacteria,2TUJP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	MarR family	MA20_28880	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
HKD2_k127_1326193_0	448385.sce4166	5.852e-183	584.0	COG1236@1|root,COG1236@2|Bacteria,1MUDD@1224|Proteobacteria,42N91@68525|delta/epsilon subdivisions,2WIMM@28221|Deltaproteobacteria,2YUD9@29|Myxococcales	28221|Deltaproteobacteria	J	Beta-Casp domain	-	-	-	ko:K07576	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B,Lactamase_B_6,RMMBL
HKD2_k127_1326193_21	326424.FRAAL3841	1.078e-06	62.0	COG1807@1|root,COG1807@2|Bacteria	2|Bacteria	M	4-amino-4-deoxy-L-arabinose transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HKD2_k127_1326193_9	1192034.CAP_7931	8.556e-88	295.0	COG0176@1|root,COG0176@2|Bacteria,1MWQ8@1224|Proteobacteria,42M39@68525|delta/epsilon subdivisions,2WJEZ@28221|Deltaproteobacteria,2YTW3@29|Myxococcales	28221|Deltaproteobacteria	F	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway	-	-	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
HKD2_k127_1326193_4	1254432.SCE1572_22235	3.027e-126	411.0	COG0451@1|root,COG0451@2|Bacteria,1R4Q0@1224|Proteobacteria,42ZXG@68525|delta/epsilon subdivisions,2WV6U@28221|Deltaproteobacteria	28221|Deltaproteobacteria	GM	NAD(P)H-binding	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
HKD2_k127_1326193_20	1193181.BN10_1030008	8.254e-07	61.0	COG5542@1|root,COG5542@2|Bacteria,2HXZR@201174|Actinobacteria,4FIWN@85021|Intrasporangiaceae	201174|Actinobacteria	S	Mannosyltransferase (PIG-V)	-	-	-	-	-	-	-	-	-	-	-	-	Mannosyl_trans2
HKD2_k127_1326193_2	1254432.SCE1572_21790	2.403e-154	505.0	COG0463@1|root,COG2227@1|root,COG0463@2|Bacteria,COG2227@2|Bacteria,1PKN9@1224|Proteobacteria,43033@68525|delta/epsilon subdivisions,2WVDA@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HKD2_k127_1326193_7	909663.KI867150_gene208	1.066e-108	367.0	COG1232@1|root,COG1232@2|Bacteria,1MX35@1224|Proteobacteria,42S3I@68525|delta/epsilon subdivisions,2X5H8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
HKD2_k127_1326193_6	1192034.CAP_7109	9.71e-118	401.0	2EGHW@1|root,33A9Z@2|Bacteria,1PM4Y@1224|Proteobacteria,43304@68525|delta/epsilon subdivisions,2WYJA@28221|Deltaproteobacteria,2Z1SV@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1326193_25	1214101.BN159_0394	0.0003208	52.0	COG5498@1|root,COG5498@2|Bacteria	2|Bacteria	M	chitin catabolic process	-	-	3.2.1.132	ko:K01233	ko00520,ko01100,map00520,map01100	-	R02833	-	ko00000,ko00001,ko01000	-	-	-	CBM_6,F5_F8_type_C,Glyco_hydro_64,RicinB_lectin_2,fn3
HKD2_k127_1326193_5	1254432.SCE1572_39040	4.829e-119	416.0	COG1807@1|root,COG1807@2|Bacteria	2|Bacteria	M	4-amino-4-deoxy-L-arabinose transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HKD2_k127_1326193_13	1192034.CAP_6902	2.785e-63	223.0	COG0241@1|root,COG0241@2|Bacteria,1RDGR@1224|Proteobacteria,42SCB@68525|delta/epsilon subdivisions,2WPEA@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	hydrolase, HAD-superfamily, subfamily IIIA	gmhB	-	3.1.3.82,3.1.3.83	ko:K03273	ko00540,ko01100,map00540,map01100	M00064	R05647,R09771	RC00017	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hydrolase_like
HKD2_k127_1326193_8	469383.Cwoe_5469	7.418e-92	305.0	COG0279@1|root,COG0279@2|Bacteria,2GPPZ@201174|Actinobacteria	201174|Actinobacteria	G	SIS domain	-	-	5.3.1.28	ko:K03271	ko00540,ko01100,map00540,map01100	M00064	R05645,R09768,R09769	RC00434	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	SIS_2
HKD2_k127_1326193_3	1192034.CAP_6900	4.981e-139	449.0	COG2605@1|root,COG2605@2|Bacteria,1QW1A@1224|Proteobacteria,42N0X@68525|delta/epsilon subdivisions,2WJYP@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM GHMP kinase	-	-	2.7.1.168	ko:K07031	ko00540,map00540	-	R09770	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
HKD2_k127_1326193_12	448385.sce3745	3.716e-64	227.0	COG1208@1|root,COG1208@2|Bacteria,1MUYJ@1224|Proteobacteria,42PGT@68525|delta/epsilon subdivisions	1224|Proteobacteria	JM	PFAM Nucleotidyl transferase	-	-	2.7.7.13,2.7.7.33,2.7.7.71	ko:K00966,ko:K00978,ko:K15669	ko00051,ko00500,ko00520,ko00540,ko01100,ko01110,map00051,map00500,map00520,map00540,map01100,map01110	M00114,M00361,M00362	R00885,R00956,R09772	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
HKD2_k127_1326193_1	1121861.KB899927_gene1579	1.837e-156	509.0	COG2759@1|root,COG2759@2|Bacteria,1MUR8@1224|Proteobacteria,2TRMM@28211|Alphaproteobacteria,2JQ9A@204441|Rhodospirillales	204441|Rhodospirillales	F	formate-tetrahydrofolate ligase activity	fhs	-	6.3.4.3	ko:K01938	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R00943	RC00026,RC00111	ko00000,ko00001,ko00002,ko01000	-	-	-	FTHFS
HKD2_k127_1326193_23	5145.XP_001907181.1	2.971e-06	55.0	COG4886@1|root,KOG0619@2759|Eukaryota,39TBM@33154|Opisthokonta,3NWQU@4751|Fungi,3QKX5@4890|Ascomycota,2128H@147550|Sordariomycetes,3U551@5139|Sordariales	4751|Fungi	S	RAM signalling pathway protein	SOG2	GO:0000003,GO:0000131,GO:0000920,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005815,GO:0005816,GO:0005856,GO:0005886,GO:0005933,GO:0005937,GO:0007114,GO:0007117,GO:0007118,GO:0007154,GO:0007165,GO:0008150,GO:0008360,GO:0009987,GO:0015630,GO:0016020,GO:0019954,GO:0022414,GO:0022603,GO:0022604,GO:0023052,GO:0030427,GO:0032153,GO:0032505,GO:0032878,GO:0040007,GO:0042995,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043332,GO:0044422,GO:0044424,GO:0044430,GO:0044446,GO:0044463,GO:0044464,GO:0044732,GO:0048518,GO:0048522,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0051286,GO:0051301,GO:0051716,GO:0061160,GO:0061161,GO:0061172,GO:0061173,GO:0065007,GO:0065008,GO:0071944,GO:0120025,GO:0120038,GO:2000099,GO:2000100,GO:2000114,GO:2000247,GO:2000769,GO:2000771	-	-	-	-	-	-	-	-	-	-	LRR_4,LRR_8,SOG2
HKD2_k127_1326193_24	258052.JNYV01000002_gene925	1.226e-05	59.0	COG2197@1|root,COG3903@1|root,COG4584@1|root,COG2197@2|Bacteria,COG3903@2|Bacteria,COG4584@2|Bacteria,2GIZ1@201174|Actinobacteria,2M1PH@2063|Kitasatospora	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	AAA_22,GerE,HTH_7,NB-ARC
HKD2_k127_1326193_18	760192.Halhy_1524	9.257e-26	124.0	COG4888@1|root,COG4888@2|Bacteria,4NEE8@976|Bacteroidetes	976|Bacteroidetes	S	PFAM ASPIC and UnbV	-	-	-	-	-	-	-	-	-	-	-	-	UnbV_ASPIC,VCBS
HKD2_k127_1326971_2	1122603.ATVI01000007_gene1801	1.543e-30	122.0	COG1297@1|root,COG1297@2|Bacteria,1N7SK@1224|Proteobacteria,1RNC8@1236|Gammaproteobacteria,1X4Q2@135614|Xanthomonadales	135614|Xanthomonadales	S	transporter	-	-	-	-	-	-	-	-	-	-	-	-	OPT
HKD2_k127_1326971_1	368407.Memar_1357	1.826e-77	270.0	COG0265@1|root,arCOG02833@2157|Archaea,2XT7Y@28890|Euryarchaeota,2NAWS@224756|Methanomicrobia	224756|Methanomicrobia	O	Trypsin	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
HKD2_k127_1326971_0	448385.sce3334	2.243e-80	279.0	COG3228@1|root,COG3228@2|Bacteria,1RAHF@1224|Proteobacteria,42QKQ@68525|delta/epsilon subdivisions,2WUIA@28221|Deltaproteobacteria,2YV7F@29|Myxococcales	28221|Deltaproteobacteria	S	Belongs to the MtfA family	-	-	-	ko:K09933	-	-	-	-	ko00000,ko01002	-	-	-	Peptidase_M90
HKD2_k127_1328236_0	1254432.SCE1572_38620	2.111e-263	845.0	COG1032@1|root,COG5011@1|root,COG1032@2|Bacteria,COG5011@2|Bacteria,1MV5G@1224|Proteobacteria,42MPT@68525|delta/epsilon subdivisions,2WJG9@28221|Deltaproteobacteria,2YUJ4@29|Myxococcales	28221|Deltaproteobacteria	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	DUF2344,Radical_SAM
HKD2_k127_1328236_1	357808.RoseRS_3490	1.201e-121	415.0	COG1012@1|root,COG1012@2|Bacteria,2G5NY@200795|Chloroflexi	200795|Chloroflexi	C	Aldehyde dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Aldedh
HKD2_k127_1328236_4	1254432.SCE1572_40935	2.043e-28	121.0	COG2204@1|root,COG2204@2|Bacteria,1NABF@1224|Proteobacteria,43C0I@68525|delta/epsilon subdivisions,2X7B5@28221|Deltaproteobacteria,2Z3KD@29|Myxococcales	28221|Deltaproteobacteria	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
HKD2_k127_1328236_5	1144275.COCOR_00888	3.549e-21	109.0	COG0745@1|root,COG0745@2|Bacteria,1MZ7D@1224|Proteobacteria,42VVV@68525|delta/epsilon subdivisions,2WRBW@28221|Deltaproteobacteria,2YVNP@29|Myxococcales	28221|Deltaproteobacteria	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
HKD2_k127_1328236_2	1121472.AQWN01000003_gene1592	1.172e-94	335.0	COG0642@1|root,COG0642@2|Bacteria,1UYZX@1239|Firmicutes,25E9T@186801|Clostridia,267E6@186807|Peptococcaceae	186801|Clostridia	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF1638,HATPase_c,HisKA,Response_reg
HKD2_k127_1328236_3	448385.sce7231	8.357e-73	258.0	COG0489@1|root,COG0489@2|Bacteria,1MU7R@1224|Proteobacteria,42NR0@68525|delta/epsilon subdivisions,2WIPG@28221|Deltaproteobacteria,2YU3H@29|Myxococcales	28221|Deltaproteobacteria	D	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP	mrp	-	-	ko:K03593	-	-	-	-	ko00000,ko03029,ko03036	-	-	-	FeS_assembly_P,ParA
HKD2_k127_1334955_0	378806.STAUR_3632	4.546e-39	168.0	COG2304@1|root,COG2304@2|Bacteria,1Q2ZC@1224|Proteobacteria,438NS@68525|delta/epsilon subdivisions,2X3WN@28221|Deltaproteobacteria,2YXCW@29|Myxococcales	28221|Deltaproteobacteria	S	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1334955_1	1144275.COCOR_02945	2.984e-11	76.0	COG0714@1|root,COG0714@2|Bacteria	2|Bacteria	KLT	Associated with various cellular activities	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_16,AAA_5,GerE
HKD2_k127_1336364_0	1192034.CAP_3147	8.508e-318	999.0	COG1074@1|root,COG1074@2|Bacteria,1MUTF@1224|Proteobacteria,42NKH@68525|delta/epsilon subdivisions,2WJTY@28221|Deltaproteobacteria,2YUG5@29|Myxococcales	28221|Deltaproteobacteria	L	UvrD/REP helicase N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
HKD2_k127_1337503_1	1415780.JPOG01000001_gene1683	3.75e-13	74.0	COG1309@1|root,COG1309@2|Bacteria,1RAF9@1224|Proteobacteria,1SHKH@1236|Gammaproteobacteria,1XAIW@135614|Xanthomonadales	135614|Xanthomonadales	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
HKD2_k127_1337503_0	1173020.Cha6605_1327	1.036e-49	184.0	COG1233@1|root,COG1233@2|Bacteria,1G2Z3@1117|Cyanobacteria	1117|Cyanobacteria	Q	COG1233 Phytoene dehydrogenase and related	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_8
HKD2_k127_1345472_5	1242864.D187_008425	4.72e-47	184.0	COG0477@1|root,COG2814@2|Bacteria,1PSYA@1224|Proteobacteria,42P2S@68525|delta/epsilon subdivisions,2WM90@28221|Deltaproteobacteria,2YUIC@29|Myxococcales	28221|Deltaproteobacteria	EGP	Major facilitator	-	-	-	ko:K08218	ko01501,map01501	M00628	-	-	ko00000,ko00001,ko00002,ko02000	2.A.1.25	-	-	Acatn,MFS_1
HKD2_k127_1345472_2	349521.HCH_03317	7.8e-56	216.0	COG3831@1|root,COG3831@2|Bacteria	2|Bacteria	-	-	yehI	-	-	-	-	-	-	-	-	-	-	-	DUF4132,WGR
HKD2_k127_1345472_3	1254432.SCE1572_37440	3.239e-54	199.0	COG0518@1|root,COG0518@2|Bacteria,1MV9U@1224|Proteobacteria,42SRU@68525|delta/epsilon subdivisions,2WPAI@28221|Deltaproteobacteria,2YVFH@29|Myxococcales	28221|Deltaproteobacteria	F	Peptidase C26	guaA2	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase
HKD2_k127_1345472_0	1463901.JOIY01000025_gene492	2.509e-110	367.0	COG2730@1|root,COG2730@2|Bacteria,2HW9X@201174|Actinobacteria	201174|Actinobacteria	G	Belongs to the glycosyl hydrolase 5 (cellulase A) family	-	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	CBM_2,Cellulase
HKD2_k127_1351625_1	448385.sce1616	3.916e-157	512.0	COG0457@1|root,COG0457@2|Bacteria,1PEH7@1224|Proteobacteria,42TVC@68525|delta/epsilon subdivisions,2WSCX@28221|Deltaproteobacteria,2YXM3@29|Myxococcales	28221|Deltaproteobacteria	O	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,TPR_14,TPR_16,TPR_2,TPR_4,TPR_6,TPR_8
HKD2_k127_1351625_0	448385.sce8980	6.514e-207	661.0	COG1835@1|root,COG1835@2|Bacteria,1REU1@1224|Proteobacteria,43AB0@68525|delta/epsilon subdivisions,2X9CR@28221|Deltaproteobacteria,2Z1T7@29|Myxococcales	28221|Deltaproteobacteria	I	Acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
HKD2_k127_1352044_1	395495.Lcho_0092	2.983e-74	257.0	COG0412@1|root,COG0412@2|Bacteria,1MW88@1224|Proteobacteria,2VJGH@28216|Betaproteobacteria	28216|Betaproteobacteria	Q	PFAM Dienelactone hydrolase	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
HKD2_k127_1352044_3	1379270.AUXF01000002_gene1393	3.577e-45	171.0	2DRPS@1|root,33CHR@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF2204
HKD2_k127_1352044_4	448385.sce8555	8.44e-33	149.0	COG0515@1|root,COG0515@2|Bacteria	448385.sce8555|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1352044_0	521045.Kole_0405	6.329e-86	294.0	COG1063@1|root,COG1063@2|Bacteria,2GCH6@200918|Thermotogae	200918|Thermotogae	E	PFAM Alcohol dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,Glu_dehyd_C
HKD2_k127_1352044_2	502025.Hoch_3064	1.597e-55	199.0	COG0622@1|root,COG0622@2|Bacteria,1P6AE@1224|Proteobacteria,432S1@68525|delta/epsilon subdivisions,2WXPU@28221|Deltaproteobacteria,2Z3CY@29|Myxococcales	28221|Deltaproteobacteria	S	Calcineurin-like phosphoesterase superfamily domain	-	-	-	ko:K07095	-	-	-	-	ko00000	-	-	-	Metallophos_2
HKD2_k127_1352516_0	448385.sce1353	6.362e-286	887.0	COG2216@1|root,COG2216@2|Bacteria,1MU7D@1224|Proteobacteria,42NGX@68525|delta/epsilon subdivisions,2WJC0@28221|Deltaproteobacteria,2YWXY@29|Myxococcales	28221|Deltaproteobacteria	P	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system	kdpB	-	3.6.3.12	ko:K01547	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	3.A.3.7	-	iAF987.Gmet_2434	E1-E2_ATPase,Hydrolase
HKD2_k127_1362517_0	443906.CMM_2774	2.422e-13	83.0	COG1944@1|root,COG1944@2|Bacteria,2GKBS@201174|Actinobacteria	201174|Actinobacteria	S	YcaO cyclodehydratase, ATP-ad Mg2+-binding	-	-	-	ko:K09136	-	-	-	-	ko00000,ko03009	-	-	-	YcaO
HKD2_k127_1366717_1	448385.sce0061	1.209e-83	287.0	COG2905@1|root,COG2905@2|Bacteria,1R0B9@1224|Proteobacteria,43CTI@68525|delta/epsilon subdivisions	1224|Proteobacteria	T	Cyclic nucleotide-monophosphate binding domain	-	-	-	ko:K04739	ko04910,map04910	-	-	-	ko00000,ko00001	-	-	-	DUF4388,cNMP_binding
HKD2_k127_1366717_0	448385.sce0010	4.182e-108	360.0	COG1420@1|root,COG1420@2|Bacteria,1MVX4@1224|Proteobacteria,42MTI@68525|delta/epsilon subdivisions,2WIXW@28221|Deltaproteobacteria,2YUQ9@29|Myxococcales	28221|Deltaproteobacteria	K	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons	hrcA	-	-	ko:K03705	-	-	-	-	ko00000,ko03000	-	-	-	HrcA,HrcA_DNA-bdg
HKD2_k127_1366717_2	1254432.SCE1572_00040	1.767e-52	193.0	COG3921@1|root,COG3921@2|Bacteria	2|Bacteria	S	Extensin-like protein C-terminus	-	-	-	-	-	-	-	-	-	-	-	-	Extensin-like_C
HKD2_k127_1367833_0	1192034.CAP_1186	1.278e-71	256.0	COG0515@1|root,COG0515@2|Bacteria	1192034.CAP_1186|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1367833_2	1254432.SCE1572_25630	1.241e-18	98.0	2EGD2@1|root,33A4V@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF2752)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2752
HKD2_k127_1367833_4	1507.HMPREF0262_03493	6.894e-06	55.0	COG4640@1|root,COG4640@2|Bacteria,1VKSN@1239|Firmicutes,24V67@186801|Clostridia,36T9T@31979|Clostridiaceae	186801|Clostridia	S	Interferon-induced transmembrane protein	-	-	-	-	-	-	-	-	-	-	-	-	CD225,zinc_ribbon_2
HKD2_k127_1367833_5	1265310.CCBD010000007_gene3024	0.0005671	49.0	2EGCD@1|root,33A46@2|Bacteria,2HHAC@201174|Actinobacteria,239WD@1762|Mycobacteriaceae	201174|Actinobacteria	S	Domain of unknown function (DUF4190)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4190
HKD2_k127_1367833_1	448385.sce7392	6.686e-44	169.0	COG1266@1|root,COG1266@2|Bacteria	2|Bacteria	V	CAAX protease self-immunity	-	-	5.4.99.28,5.4.99.29	ko:K06177,ko:K07052,ko:K09696	ko02010,ko02020,map02010,map02020	M00253	-	-	ko00000,ko00001,ko00002,ko01000,ko02000,ko03009,ko03016	3.A.1.115	-	-	Abi
HKD2_k127_1367833_3	1192034.CAP_1268	7.249e-11	67.0	COG1715@1|root,COG1715@2|Bacteria,1QXA7@1224|Proteobacteria,438GS@68525|delta/epsilon subdivisions,2X3RM@28221|Deltaproteobacteria,2YWXV@29|Myxococcales	28221|Deltaproteobacteria	V	HB1, ASXL, restriction endonuclease HTH domain	-	-	-	-	-	-	-	-	-	-	-	-	HARE-HTH,Mrr_cat
HKD2_k127_1378566_3	290397.Adeh_3512	5.165e-32	131.0	COG2846@1|root,COG4309@1|root,COG2846@2|Bacteria,COG4309@2|Bacteria,1PSZK@1224|Proteobacteria,43A90@68525|delta/epsilon subdivisions,2WXQZ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	D	Uncharacterized conserved protein (DUF2249)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2249
HKD2_k127_1378566_6	237368.SCABRO_00719	2.359e-11	68.0	COG1917@1|root,COG1917@2|Bacteria,2J3N1@203682|Planctomycetes	203682|Planctomycetes	S	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HKD2_k127_1378566_7	258594.RPA1660	5.876e-07	59.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,2TR80@28211|Alphaproteobacteria,3JQNW@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	actP	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,Hydrolase,YHS
HKD2_k127_1378566_1	1125863.JAFN01000001_gene159	9.519e-91	319.0	COG0119@1|root,COG0119@2|Bacteria,1MUMX@1224|Proteobacteria,42Q6T@68525|delta/epsilon subdivisions,2WIN1@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	PFAM Pyruvate carboxyltransferase	mvaB	-	4.1.3.4	ko:K01640	ko00072,ko00280,ko00281,ko00650,ko01100,ko04146,map00072,map00280,map00281,map00650,map01100,map04146	M00036,M00088	R01360,R08090	RC00502,RC00503,RC01118,RC01946	ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like
HKD2_k127_1378566_9	1054213.HMPREF9946_04904	2.838e-05	53.0	COG0662@1|root,COG0662@2|Bacteria,1N1XN@1224|Proteobacteria,2U6GE@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	AraC-like ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HKD2_k127_1378566_0	1254432.SCE1572_20855	8.438e-126	434.0	COG1033@1|root,COG1033@2|Bacteria,1R0CG@1224|Proteobacteria,43CUX@68525|delta/epsilon subdivisions,2X9DC@28221|Deltaproteobacteria,2Z3JS@29|Myxococcales	28221|Deltaproteobacteria	S	MMPL family	-	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
HKD2_k127_1378566_8	1207063.P24_14095	1.792e-05	57.0	COG0330@1|root,COG0330@2|Bacteria,1RDFI@1224|Proteobacteria,2U1E0@28211|Alphaproteobacteria,2JQZH@204441|Rhodospirillales	204441|Rhodospirillales	O	COG0330 Membrane protease subunits, stomatin prohibitin homologs	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
HKD2_k127_1378566_5	1211114.ALIP01000006_gene940	3.883e-17	96.0	COG0823@1|root,COG3710@1|root,COG0823@2|Bacteria,COG3710@2|Bacteria,1PYUK@1224|Proteobacteria,1S0VV@1236|Gammaproteobacteria,1X5W9@135614|Xanthomonadales	135614|Xanthomonadales	KU	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Trans_reg_C
HKD2_k127_1378566_2	246197.MXAN_0612	1.561e-71	255.0	COG2203@1|root,COG4191@1|root,COG2203@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42PZ5@68525|delta/epsilon subdivisions,2WKB1@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
HKD2_k127_1378566_4	298653.Franean1_2151	7.003e-28	117.0	COG4122@1|root,COG4122@2|Bacteria,2HU48@201174|Actinobacteria,4EWXT@85013|Frankiales	201174|Actinobacteria	S	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_24
HKD2_k127_1381490_3	1192034.CAP_1883	1.453e-07	53.0	COG0500@1|root,COG2226@2|Bacteria,1MZIX@1224|Proteobacteria,43CDM@68525|delta/epsilon subdivisions,2X7PI@28221|Deltaproteobacteria,2YVQH@29|Myxococcales	28221|Deltaproteobacteria	Q	Mycolic acid cyclopropane synthetase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
HKD2_k127_1381490_4	1227352.C173_22332	0.0002373	50.0	COG1846@1|root,COG1846@2|Bacteria,1VM7T@1239|Firmicutes,4HUQS@91061|Bacilli,26T2J@186822|Paenibacillaceae	91061|Bacilli	K	MarR family transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
HKD2_k127_1381490_0	448385.sce9022	7.272e-73	250.0	COG0242@1|root,COG0242@2|Bacteria,1R9XK@1224|Proteobacteria,42T5R@68525|delta/epsilon subdivisions,2WX1F@28221|Deltaproteobacteria,2Z02S@29|Myxococcales	28221|Deltaproteobacteria	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions	-	-	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	Pep_deformylase
HKD2_k127_1381490_1	158822.LH89_04560	8.774e-59	218.0	COG0625@1|root,COG0625@2|Bacteria,1NX28@1224|Proteobacteria,1RQUP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	Glutathione S-transferase	yfcF	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C_4,GST_N,GST_N_3
HKD2_k127_1381490_2	448385.sce3784	1.172e-35	141.0	COG1262@1|root,COG1262@2|Bacteria	2|Bacteria	T	PFAM Formylglycine-generating sulfatase enzyme	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase,PEGA
HKD2_k127_1381982_6	1254432.SCE1572_47475	2.335e-59	214.0	COG1131@1|root,COG1131@2|Bacteria,1RKFP@1224|Proteobacteria,42RXI@68525|delta/epsilon subdivisions,2WNB9@28221|Deltaproteobacteria,2Z263@29|Myxococcales	28221|Deltaproteobacteria	V	ABC transporter	ccmA	-	3.6.3.41	ko:K02193	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.107	-	-	ABC_tran
HKD2_k127_1381982_3	1144275.COCOR_01166	8.231e-80	279.0	COG0156@1|root,COG0156@2|Bacteria,1MVVH@1224|Proteobacteria,42MM1@68525|delta/epsilon subdivisions,2WIU7@28221|Deltaproteobacteria,2YUQI@29|Myxococcales	28221|Deltaproteobacteria	H	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide	bioF	-	2.3.1.29,2.3.1.47	ko:K00639,ko:K00652	ko00260,ko00780,ko01100,map00260,map00780,map01100	M00123,M00573,M00577	R00371,R03210,R10124	RC00004,RC00039,RC00394,RC02725	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
HKD2_k127_1381982_2	1502852.FG94_01382	1.035e-89	315.0	COG0337@1|root,COG0703@1|root,COG0337@2|Bacteria,COG0703@2|Bacteria,1MUBK@1224|Proteobacteria,2VHXR@28216|Betaproteobacteria,4725Y@75682|Oxalobacteraceae	28216|Betaproteobacteria	E	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)	aroB	-	2.7.1.71,4.2.3.4	ko:K01735,ko:K13829	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412,R03083	RC00002,RC00078,RC00847	ko00000,ko00001,ko00002,ko01000	-	-	-	DHQ_synthase,SKI
HKD2_k127_1381982_0	1192034.CAP_5586	2.934e-176	564.0	COG0082@1|root,COG0082@2|Bacteria,1MU98@1224|Proteobacteria,42MF9@68525|delta/epsilon subdivisions,2WJ57@28221|Deltaproteobacteria,2YVCP@29|Myxococcales	28221|Deltaproteobacteria	E	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system	aroC	GO:0000166,GO:0003674,GO:0003824,GO:0004107,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0010181,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0032553,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050662,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	4.2.3.5	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01714	RC00586	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_0976	Chorismate_synt
HKD2_k127_1381982_9	1125863.JAFN01000001_gene2308	2.617e-16	92.0	COG1872@1|root,COG1872@2|Bacteria,1MZ4E@1224|Proteobacteria,42VE5@68525|delta/epsilon subdivisions,2WR8T@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Belongs to the UPF0235 family	-	-	-	ko:K09131	-	-	-	-	ko00000	-	-	-	DUF167
HKD2_k127_1381982_5	1254432.SCE1572_47440	1.549e-62	229.0	COG0253@1|root,COG0253@2|Bacteria,1MWDH@1224|Proteobacteria,42MRX@68525|delta/epsilon subdivisions,2WMP4@28221|Deltaproteobacteria,2YV9S@29|Myxococcales	28221|Deltaproteobacteria	J	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan	dapF	-	5.1.1.7	ko:K01778	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00527	R02735	RC00302	ko00000,ko00001,ko00002,ko01000	-	-	-	DAP_epimerase
HKD2_k127_1381982_12	265072.Mfla_2202	1.192e-06	62.0	COG4567@1|root,COG4567@2|Bacteria,1RD7J@1224|Proteobacteria,2VN1I@28216|Betaproteobacteria,2KMVN@206350|Nitrosomonadales	206350|Nitrosomonadales	T	PFAM response regulator receiver	-	-	-	ko:K15012	ko02020,map02020	M00523	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg
HKD2_k127_1381982_11	1192034.CAP_5390	3.193e-10	71.0	COG0745@1|root,COG0745@2|Bacteria,1NQ8U@1224|Proteobacteria	1224|Proteobacteria	KT	Domain of unknown function (DUF4388)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4388,Response_reg
HKD2_k127_1381982_1	1254432.SCE1572_42300	5.302e-117	383.0	COG0528@1|root,COG0528@2|Bacteria,1MV3N@1224|Proteobacteria,42M3X@68525|delta/epsilon subdivisions,2WJDF@28221|Deltaproteobacteria,2YU4R@29|Myxococcales	28221|Deltaproteobacteria	F	Catalyzes the reversible phosphorylation of UMP to UDP	pyrH	GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901576	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
HKD2_k127_1381982_4	1192034.CAP_8512	2.491e-68	243.0	COG0760@1|root,COG0760@2|Bacteria,1MZDK@1224|Proteobacteria,42RP3@68525|delta/epsilon subdivisions,2WNPA@28221|Deltaproteobacteria,2YVS3@29|Myxococcales	28221|Deltaproteobacteria	O	PFAM PpiC-type peptidyl-prolyl cis-trans isomerase	-	-	5.2.1.8	ko:K03769,ko:K03770	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_2,Rotamase_3,SurA_N_3
HKD2_k127_1387700_1	1192034.CAP_7137	1.996e-83	280.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WJ88@28221|Deltaproteobacteria,2YUPC@29|Myxococcales	28221|Deltaproteobacteria	T	Two component, sigma54 specific, transcriptional regulator, Fis family	crdA	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD2_k127_1387700_5	670487.Ocepr_0954	7.538e-25	115.0	2CP7W@1|root,32MRP@2|Bacteria,1WKBJ@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1387700_0	247490.KSU1_B0001	2.584e-99	358.0	COG2204@1|root,COG2204@2|Bacteria,2IY95@203682|Planctomycetes	203682|Planctomycetes	T	COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains	-	-	-	ko:K07712	ko02020,map02020	M00497	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD2_k127_1387700_4	330214.NIDE3284	4.17e-35	150.0	COG3829@1|root,COG4191@1|root,COG5000@1|root,COG3829@2|Bacteria,COG4191@2|Bacteria,COG5000@2|Bacteria,3J117@40117|Nitrospirae	40117|Nitrospirae	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF3365,HAMP,HATPase_c,HisKA,PAS_4
HKD2_k127_1387700_2	1192034.CAP_4618	3.804e-57	226.0	COG1628@1|root,COG1628@2|Bacteria,1RCX1@1224|Proteobacteria,4307R@68525|delta/epsilon subdivisions,2WVEG@28221|Deltaproteobacteria,2Z3D2@29|Myxococcales	28221|Deltaproteobacteria	S	Protein of unknown function DUF99	-	-	-	ko:K09120	-	-	-	-	ko00000	-	-	-	DUF99
HKD2_k127_1387700_3	1449353.JQMQ01000005_gene39	1.155e-35	154.0	COG3023@1|root,COG3023@2|Bacteria,2GJ9M@201174|Actinobacteria,2NFR0@228398|Streptacidiphilus	201174|Actinobacteria	V	Ami_2	-	-	-	-	-	-	-	-	-	-	-	-	Amidase_2
HKD2_k127_1387700_6	1254432.SCE1572_38305	1.321e-13	70.0	COG0631@1|root,COG0664@1|root,COG0631@2|Bacteria,COG0664@2|Bacteria,1R7UF@1224|Proteobacteria,42WUQ@68525|delta/epsilon subdivisions,2XA41@28221|Deltaproteobacteria,2YTYP@29|Myxococcales	28221|Deltaproteobacteria	T	SMART protein phosphatase 2C domain protein	pp2c12	-	3.1.3.16	ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C_2,cNMP_binding
HKD2_k127_1391877_1	1192034.CAP_5779	1.692e-21	99.0	COG1314@1|root,COG1314@2|Bacteria,1NJ1D@1224|Proteobacteria,42TKW@68525|delta/epsilon subdivisions,2WRA3@28221|Deltaproteobacteria,2YVR1@29|Myxococcales	28221|Deltaproteobacteria	U	Preprotein translocase SecG subunit	secG	-	-	ko:K03075	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecG
HKD2_k127_1391877_0	1192034.CAP_5778	3.699e-64	237.0	COG1807@1|root,COG1807@2|Bacteria	2|Bacteria	M	4-amino-4-deoxy-L-arabinose transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HKD2_k127_1392410_0	123214.PERMA_0207	3.194e-74	265.0	COG0442@1|root,COG0442@2|Bacteria,2G3SN@200783|Aquificae	200783|Aquificae	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS	proS	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA_edit
HKD2_k127_1392410_2	1192034.CAP_8891	6.052e-62	234.0	COG1408@1|root,COG1408@2|Bacteria,1MUH5@1224|Proteobacteria,42Q51@68525|delta/epsilon subdivisions,2WIMQ@28221|Deltaproteobacteria,2YYKM@29|Myxococcales	28221|Deltaproteobacteria	S	Calcineurin-like phosphoesterase	-	-	-	ko:K07098	-	-	-	-	ko00000	-	-	-	CarS-like,Metallophos
HKD2_k127_1392410_1	879212.DespoDRAFT_02512	3.052e-72	248.0	COG0008@1|root,COG0008@2|Bacteria,1MUC8@1224|Proteobacteria,42MAX@68525|delta/epsilon subdivisions,2WJ5B@28221|Deltaproteobacteria,2MHVD@213118|Desulfobacterales	28221|Deltaproteobacteria	J	TIGRFAM glutaminyl-tRNA synthetase	glnS	-	6.1.1.18	ko:K01886	ko00970,ko01100,map00970,map01100	M00359,M00360	R03652	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	GatB_Yqey,tRNA-synt_1c,tRNA-synt_1c_C
HKD2_k127_1395004_2	1242864.D187_005773	2.433e-112	378.0	COG3537@1|root,COG3537@2|Bacteria,1MXCY@1224|Proteobacteria	1224|Proteobacteria	G	Alpha-1,2-mannosidase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_92
HKD2_k127_1395004_3	886293.Sinac_4158	1.376e-05	51.0	2C51Y@1|root,33J3U@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1395004_1	1254432.SCE1572_38300	5.166e-116	402.0	2AIWW@1|root,319EI@2|Bacteria,1Q2HU@1224|Proteobacteria,4384N@68525|delta/epsilon subdivisions,2X3EQ@28221|Deltaproteobacteria,2YVQU@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1395004_0	448385.sce6484	7.42e-184	586.0	COG0631@1|root,COG0664@1|root,COG0631@2|Bacteria,COG0664@2|Bacteria,1R7UF@1224|Proteobacteria,42WUQ@68525|delta/epsilon subdivisions,2XA41@28221|Deltaproteobacteria,2YTYP@29|Myxococcales	28221|Deltaproteobacteria	T	SMART protein phosphatase 2C domain protein	pp2c12	-	3.1.3.16	ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C_2,cNMP_binding
HKD2_k127_13965_0	1254432.SCE1572_10530	4.091e-206	648.0	COG0849@1|root,COG0849@2|Bacteria,1MUSR@1224|Proteobacteria,42MS2@68525|delta/epsilon subdivisions,2WIQ0@28221|Deltaproteobacteria,2YTZH@29|Myxococcales	28221|Deltaproteobacteria	D	Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring	ftsA	-	-	ko:K03590	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036,ko04812	-	-	-	FtsA,SHS2_FTSA
HKD2_k127_13965_2	1254432.SCE1572_31845	3.181e-30	133.0	COG4775@1|root,COG4775@2|Bacteria	2|Bacteria	M	membrane organization	-	-	-	ko:K07126,ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,PD40,POTRA
HKD2_k127_13965_1	391625.PPSIR1_26898	9.521e-92	315.0	COG1572@1|root,COG1572@2|Bacteria,1QX45@1224|Proteobacteria,42YA1@68525|delta/epsilon subdivisions,2WTP9@28221|Deltaproteobacteria,2YWVC@29|Myxococcales	28221|Deltaproteobacteria	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	-	-	-	-	-	-	-	-	-	-	-	-	HYR,VCBS
HKD2_k127_1400848_3	1254432.SCE1572_26065	3.473e-35	138.0	COG0848@1|root,COG0848@2|Bacteria,1N9DN@1224|Proteobacteria,42V0H@68525|delta/epsilon subdivisions,2WQGB@28221|Deltaproteobacteria,2Z0IY@29|Myxococcales	28221|Deltaproteobacteria	U	Biopolymer transport protein ExbD/TolR	-	-	-	ko:K03559	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	ExbD
HKD2_k127_1400848_2	1254432.SCE1572_26060	4.47e-64	228.0	COG0811@1|root,COG0811@2|Bacteria,1RK2P@1224|Proteobacteria,42TPV@68525|delta/epsilon subdivisions,2X5KN@28221|Deltaproteobacteria,2YXI5@29|Myxococcales	28221|Deltaproteobacteria	U	MotA/TolQ/ExbB proton channel family	-	-	-	ko:K03561	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	MotA_ExbB
HKD2_k127_1400848_1	448385.sce4314	1.361e-84	291.0	COG0585@1|root,COG0585@2|Bacteria,1MXHD@1224|Proteobacteria,42P4E@68525|delta/epsilon subdivisions,2WN09@28221|Deltaproteobacteria,2YUZJ@29|Myxococcales	28221|Deltaproteobacteria	J	Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs	truD	GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0016070,GO:0016853,GO:0016866,GO:0034641,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360	5.4.99.27	ko:K06176	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruD
HKD2_k127_1400848_0	1121946.AUAX01000005_gene5377	2.703e-228	717.0	COG0520@1|root,COG0520@2|Bacteria,2GP7W@201174|Actinobacteria,4DAKS@85008|Micromonosporales	201174|Actinobacteria	E	Aminotransferase class-V	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
HKD2_k127_1402796_2	448385.sce3615	3.897e-39	149.0	COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,42Q0K@68525|delta/epsilon subdivisions,2WJUW@28221|Deltaproteobacteria,2YTVH@29|Myxococcales	28221|Deltaproteobacteria	L	DbpA RNA binding domain	dedA	-	3.6.4.13	ko:K03732,ko:K05592	ko03018,map03018	M00394	-	-	ko00000,ko00001,ko00002,ko01000,ko03009,ko03019	-	-	-	DEAD,DbpA,Helicase_C
HKD2_k127_1402796_1	290397.Adeh_0378	3.405e-70	250.0	COG0142@1|root,COG0142@2|Bacteria,1MUK6@1224|Proteobacteria,42M1B@68525|delta/epsilon subdivisions,2WK2M@28221|Deltaproteobacteria,2YVA6@29|Myxococcales	28221|Deltaproteobacteria	H	Belongs to the FPP GGPP synthase family	ispB	-	2.5.1.30,2.5.1.90	ko:K00805,ko:K02523	ko00900,ko01110,map00900,map01110	-	R09247,R09248	RC00279	ko00000,ko00001,ko01000,ko01006	-	-	-	polyprenyl_synt
HKD2_k127_1402796_3	502025.Hoch_5901	3.555e-37	151.0	COG1510@1|root,COG1510@2|Bacteria,1RA49@1224|Proteobacteria,432MH@68525|delta/epsilon subdivisions,2WYFU@28221|Deltaproteobacteria,2YVDK@29|Myxococcales	28221|Deltaproteobacteria	K	Belongs to the GbsR family	-	-	-	-	-	-	-	-	-	-	-	-	MarR_2
HKD2_k127_1402796_0	1192034.CAP_7947	1.407e-80	295.0	2AYUN@1|root,31R03@2|Bacteria,1QNIW@1224|Proteobacteria,43861@68525|delta/epsilon subdivisions,2X3FV@28221|Deltaproteobacteria,2YVX4@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1402796_4	404589.Anae109_3730	4.272e-14	76.0	COG3202@1|root,COG3202@2|Bacteria,1MVP5@1224|Proteobacteria,438CB@68525|delta/epsilon subdivisions,2X3MN@28221|Deltaproteobacteria,2YWIY@29|Myxococcales	28221|Deltaproteobacteria	C	ATP ADP translocase	-	-	-	ko:K03301	-	-	-	-	ko00000	2.A.12	-	-	-
HKD2_k127_1409614_0	1123368.AUIS01000008_gene2237	4.046e-169	536.0	COG1180@1|root,COG1180@2|Bacteria,1NQC1@1224|Proteobacteria,1T90P@1236|Gammaproteobacteria,2NDQR@225057|Acidithiobacillales	225057|Acidithiobacillales	C	Radical SAM superfamily	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Radical_SAM
HKD2_k127_1409614_1	1340493.JNIF01000003_gene1463	8.133e-45	176.0	2CH0S@1|root,341IR@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1409693_1	448385.sce7273	1.935e-104	346.0	COG0240@1|root,COG0240@2|Bacteria,1MUU3@1224|Proteobacteria,42NQB@68525|delta/epsilon subdivisions,2WIWW@28221|Deltaproteobacteria,2YTWZ@29|Myxococcales	28221|Deltaproteobacteria	I	Glycerol-3-phosphate dehydrogenase	gpsA	-	1.1.1.94	ko:K00057	ko00564,ko01110,map00564,map01110	-	R00842,R00844	RC00029	ko00000,ko00001,ko01000	-	-	-	NAD_Gly3P_dh_C,NAD_Gly3P_dh_N
HKD2_k127_1409693_0	1192034.CAP_0589	3.318e-108	361.0	COG0583@1|root,COG0583@2|Bacteria,1PKXJ@1224|Proteobacteria,43447@68525|delta/epsilon subdivisions,2X551@28221|Deltaproteobacteria,2Z04I@29|Myxococcales	28221|Deltaproteobacteria	K	Bacterial regulatory helix-turn-helix protein, lysR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HKD2_k127_1425458_1	1192034.CAP_4900	1.66e-119	395.0	COG1404@1|root,COG1404@2|Bacteria,1MU3S@1224|Proteobacteria,42N7D@68525|delta/epsilon subdivisions,2WKJS@28221|Deltaproteobacteria,2YTZI@29|Myxococcales	28221|Deltaproteobacteria	M	Belongs to the peptidase S8 family	-	-	-	ko:K14645	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002,ko03110	-	-	-	Peptidase_S8
HKD2_k127_1425458_2	321327.CYA_0005	4.781e-58	213.0	COG0300@1|root,COG0300@2|Bacteria,1G2GZ@1117|Cyanobacteria,1H45Y@1129|Synechococcus	1117|Cyanobacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HKD2_k127_1425458_4	1196029.ALIM01000014_gene3653	3.977e-33	135.0	COG1309@1|root,COG1309@2|Bacteria,1V95E@1239|Firmicutes,4HJIZ@91061|Bacilli,1ZDJZ@1386|Bacillus	91061|Bacilli	K	Transcriptional regulator	-	-	-	ko:K22106	-	-	-	-	ko00000,ko03000	-	-	-	TetR_C_10,TetR_N
HKD2_k127_1425458_0	448385.sce1573	7.789e-146	468.0	COG0320@1|root,COG0320@2|Bacteria,1MVRD@1224|Proteobacteria,42P2E@68525|delta/epsilon subdivisions,2WIJQ@28221|Deltaproteobacteria,2YUQJ@29|Myxococcales	28221|Deltaproteobacteria	H	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives	lipA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0016740,GO:0016782,GO:0016783,GO:0016992,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0070283,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576	2.8.1.8	ko:K03644	ko00785,ko01100,map00785,map01100	-	R07767,R07768	RC01978	ko00000,ko00001,ko01000	-	-	-	LIAS_N,Radical_SAM
HKD2_k127_1425458_3	290397.Adeh_4186	1.033e-50	183.0	COG0182@1|root,COG0182@2|Bacteria,1MUPM@1224|Proteobacteria,42MJ2@68525|delta/epsilon subdivisions,2WJQB@28221|Deltaproteobacteria,2YUP1@29|Myxococcales	28221|Deltaproteobacteria	J	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)	mtnA	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0019509,GO:0019752,GO:0043094,GO:0043102,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046523,GO:0071265,GO:0071267,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	5.3.1.23	ko:K08963	ko00270,ko01100,map00270,map01100	M00034	R04420	RC01151	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_0072	IF-2B
HKD2_k127_1427321_2	1192034.CAP_1552	5.293e-25	113.0	COG0823@1|root,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,PA14,PD40,PKD
HKD2_k127_1427321_1	243231.GSU3138	6.447e-75	269.0	COG0642@1|root,COG2197@1|root,COG2197@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,42RWK@68525|delta/epsilon subdivisions,2WNCS@28221|Deltaproteobacteria,43SHW@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	Domains REC, HisKA, HATPase_c	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HATPase_c,HisKA,PAS_4,PAS_9,Response_reg
HKD2_k127_1427321_3	573061.Clocel_1208	2.647e-19	102.0	COG0664@1|root,COG0664@2|Bacteria	2|Bacteria	T	cyclic nucleotide binding	-	-	1.8.1.9	ko:K00384,ko:K01420	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000,ko03000	-	-	-	Pyr_redox_2,Pyr_redox_3,cNMP_binding
HKD2_k127_1427321_0	1033991.RLEG12_22495	6.61e-90	304.0	COG0702@1|root,COG0702@2|Bacteria,1NG5K@1224|Proteobacteria,2VF6P@28211|Alphaproteobacteria	28211|Alphaproteobacteria	GM	NmrA-like family	-	-	-	-	-	-	-	-	-	-	-	-	NmrA
HKD2_k127_1428040_4	368407.Memar_1664	3.249e-10	69.0	COG0589@1|root,arCOG02053@2157|Archaea,2XY64@28890|Euryarchaeota	28890|Euryarchaeota	T	COG0589 Universal stress protein UspA and related nucleotide-binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD2_k127_1428040_0	748280.NH8B_1377	0.0	1229.0	COG0376@1|root,COG0376@2|Bacteria,1MUBF@1224|Proteobacteria,2VH5H@28216|Betaproteobacteria,2KQCR@206351|Neisseriales	206351|Neisseriales	C	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity	katG	-	1.11.1.21	ko:K03782	ko00360,ko00380,ko00940,ko00983,ko01100,ko01110,map00360,map00380,map00940,map00983,map01100,map01110	-	R00602,R00698,R02596,R02670,R03919,R04007,R07443,R11906	RC00034,RC00213,RC00767,RC02141	ko00000,ko00001,ko01000	-	-	-	peroxidase
HKD2_k127_1428040_2	1047013.AQSP01000144_gene925	3.713e-19	93.0	COG1814@1|root,COG1814@2|Bacteria	2|Bacteria	S	cellular manganese ion homeostasis	-	-	-	-	-	-	-	-	-	-	-	-	VIT1
HKD2_k127_1428040_1	404589.Anae109_4365	1.001e-26	114.0	COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,43CCK@68525|delta/epsilon subdivisions,2X7Q6@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF3365,HATPase_c,HisKA,PAS_4,PAS_9
HKD2_k127_1428040_3	525368.HMPREF0591_2180	9.948e-11	65.0	COG1814@1|root,COG1814@2|Bacteria,2GIZ3@201174|Actinobacteria,2366U@1762|Mycobacteriaceae	201174|Actinobacteria	S	membrane	pcl	-	-	-	-	-	-	-	-	-	-	-	VIT1
HKD2_k127_1428070_3	1415780.JPOG01000001_gene2872	2.499e-19	93.0	COG2207@1|root,COG2207@2|Bacteria,1MX23@1224|Proteobacteria,1RN7K@1236|Gammaproteobacteria,1X5D0@135614|Xanthomonadales	135614|Xanthomonadales	K	Arabinose-binding domain of AraC transcription regulator, N-term	-	-	-	-	-	-	-	-	-	-	-	-	Arabinose_bd,HTH_18
HKD2_k127_1428070_1	1254432.SCE1572_14075	7.041e-38	164.0	COG2207@1|root,COG2207@2|Bacteria,1MX23@1224|Proteobacteria,42UHJ@68525|delta/epsilon subdivisions,2WT4S@28221|Deltaproteobacteria,2Z0H1@29|Myxococcales	28221|Deltaproteobacteria	K	Arabinose-binding domain of AraC transcription regulator, N-term	oruR2	-	-	-	-	-	-	-	-	-	-	-	Arabinose_bd,HTH_18
HKD2_k127_1428070_4	5786.XP_003287052.1	2.008e-09	71.0	2D8YH@1|root,2SF04@2759|Eukaryota,3X8TN@554915|Amoebozoa	554915|Amoebozoa	O	Component of the counting factor (CF) complex	-	GO:0005575,GO:0005576,GO:0006928,GO:0006950,GO:0007154,GO:0007155,GO:0008150,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0022610,GO:0030587,GO:0031152,GO:0031667,GO:0031668,GO:0031669,GO:0032502,GO:0033500,GO:0033554,GO:0040011,GO:0042592,GO:0042593,GO:0042594,GO:0044764,GO:0048856,GO:0048870,GO:0048878,GO:0050896,GO:0051179,GO:0051674,GO:0051703,GO:0051704,GO:0051716,GO:0065007,GO:0065008,GO:0071496,GO:0090702,GO:0098609,GO:0098630,GO:0098743,GO:0099120	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_25
HKD2_k127_1428070_2	1150474.JQJI01000008_gene1327	8.148e-26	118.0	COG3345@1|root,COG3345@2|Bacteria,2GC20@200918|Thermotogae	200918|Thermotogae	G	Melibiase	-	GO:0003674,GO:0003824,GO:0004553,GO:0004557,GO:0005488,GO:0005515,GO:0008150,GO:0008152,GO:0009056,GO:0015925,GO:0016137,GO:0016139,GO:0016787,GO:0016798,GO:0042802,GO:0042803,GO:0046983,GO:0071704,GO:1901135,GO:1901136,GO:1901575,GO:1901657,GO:1901658	3.2.1.22	ko:K07407	ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603	-	R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05549,R05961,R06091	RC00049,RC00059,RC00451	ko00000,ko00001,ko01000	-	-	-	Melibiase
HKD2_k127_1429069_0	448385.sce5295	1.004e-162	523.0	COG1193@1|root,COG1193@2|Bacteria,1R0CV@1224|Proteobacteria	2|Bacteria	L	DNA mismatch repair protein	mutS2	-	-	ko:K07456	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_V,Smr
HKD2_k127_1429069_2	1254432.SCE1572_00520	0.0006616	52.0	COG4409@1|root,COG4409@2|Bacteria,1NUCS@1224|Proteobacteria,43DX9@68525|delta/epsilon subdivisions,2X90E@28221|Deltaproteobacteria,2Z1A2@29|Myxococcales	28221|Deltaproteobacteria	G	Domain of unknown function (DUF4185)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4185
HKD2_k127_1430643_2	1254432.SCE1572_20785	3.113e-33	142.0	COG0583@1|root,COG0583@2|Bacteria,1MWVB@1224|Proteobacteria,4319Y@68525|delta/epsilon subdivisions,2WWCS@28221|Deltaproteobacteria,2YZY0@29|Myxococcales	28221|Deltaproteobacteria	K	Bacterial regulatory helix-turn-helix protein, lysR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HKD2_k127_1430643_0	1192034.CAP_2666	4.1e-84	295.0	COG0451@1|root,COG0451@2|Bacteria,1MXYR@1224|Proteobacteria,437IW@68525|delta/epsilon subdivisions,2X2SP@28221|Deltaproteobacteria,2YUPD@29|Myxococcales	28221|Deltaproteobacteria	GM	NAD(P)H-binding	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
HKD2_k127_1430643_1	1345697.M493_14365	1.927e-38	148.0	COG1960@1|root,COG1960@2|Bacteria,1UY8Z@1239|Firmicutes,4HD0N@91061|Bacilli,1WEIB@129337|Geobacillus	91061|Bacilli	I	Acyl-CoA dehydrogenase, N-terminal domain	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HKD2_k127_1433921_1	1192034.CAP_6027	2.896e-124	410.0	2CB8G@1|root,2Z88H@2|Bacteria,1Q6FE@1224|Proteobacteria,438TW@68525|delta/epsilon subdivisions,2X4QT@28221|Deltaproteobacteria,2YXRY@29|Myxococcales	28221|Deltaproteobacteria	S	Putative beta-barrel porin-2, OmpL-like. bbp2	-	-	-	-	-	-	-	-	-	-	-	-	BBP2
HKD2_k127_1433921_9	394221.Mmar10_1569	0.0004444	50.0	COG2852@1|root,COG2852@2|Bacteria,1N0QU@1224|Proteobacteria,2UFZ7@28211|Alphaproteobacteria,4404S@69657|Hyphomonadaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF559)	-	-	-	-	-	-	-	-	-	-	-	-	DUF559
HKD2_k127_1433921_7	694431.DESACE_05140	1.616e-06	60.0	COG0810@1|root,COG0810@2|Bacteria,1R330@1224|Proteobacteria,437DK@68525|delta/epsilon subdivisions,2WSN1@28221|Deltaproteobacteria,2M76S@213113|Desulfurellales	28221|Deltaproteobacteria	M	TonB C terminal	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	TonB_C
HKD2_k127_1433921_3	1254432.SCE1572_22705	2.306e-90	306.0	COG0084@1|root,COG0084@2|Bacteria,1MUC0@1224|Proteobacteria,42MMS@68525|delta/epsilon subdivisions,2WMUI@28221|Deltaproteobacteria,2YUWH@29|Myxococcales	28221|Deltaproteobacteria	L	TatD family	tatD	-	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
HKD2_k127_1433921_4	1415780.JPOG01000001_gene2341	1.439e-68	242.0	COG0300@1|root,COG0300@2|Bacteria,1RG9T@1224|Proteobacteria,1S48Y@1236|Gammaproteobacteria,1X4PM@135614|Xanthomonadales	135614|Xanthomonadales	S	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HKD2_k127_1433921_6	502025.Hoch_5007	2.685e-10	68.0	COG0589@1|root,COG0589@2|Bacteria,1NN89@1224|Proteobacteria,434TG@68525|delta/epsilon subdivisions,2WZ4G@28221|Deltaproteobacteria,2Z1B6@29|Myxococcales	28221|Deltaproteobacteria	T	Universal stress protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD2_k127_1433921_2	1254432.SCE1572_48110	8.951e-95	326.0	COG0534@1|root,COG0534@2|Bacteria,1MVRV@1224|Proteobacteria,42QG6@68525|delta/epsilon subdivisions,2WNNB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	TIGRFAM MATE efflux family protein	norM	-	-	ko:K03327	-	-	-	-	ko00000,ko02000	2.A.66.1	-	-	MatE
HKD2_k127_1433921_0	1192034.CAP_6938	1.513e-290	910.0	COG2766@1|root,COG2766@2|Bacteria,1NG7R@1224|Proteobacteria,42P8B@68525|delta/epsilon subdivisions,2WJIU@28221|Deltaproteobacteria,2YU5M@29|Myxococcales	28221|Deltaproteobacteria	T	PrkA serine protein kinase C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_PrkA,PrkA
HKD2_k127_1441620_0	1254432.SCE1572_22620	4.045e-105	351.0	COG0451@1|root,COG0451@2|Bacteria,1MU7J@1224|Proteobacteria,42MRN@68525|delta/epsilon subdivisions,2WJCH@28221|Deltaproteobacteria,2YZUS@29|Myxococcales	28221|Deltaproteobacteria	M	Polysaccharide biosynthesis protein	-	-	5.1.3.2,5.1.3.7	ko:K01784,ko:K02473	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R00418,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
HKD2_k127_1441620_1	667014.Thein_1741	1.889e-88	310.0	2AM9X@1|root,31C4U@2|Bacteria,2GIDP@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	S	Hypothetical glycosyl hydrolase family 15	-	-	-	-	-	-	-	-	-	-	-	-	GHL15
HKD2_k127_1441983_3	448385.sce8644	4.854e-41	157.0	COG0642@1|root,COG2205@2|Bacteria,1PG0T@1224|Proteobacteria,438XP@68525|delta/epsilon subdivisions,2X435@28221|Deltaproteobacteria,2YY50@29|Myxococcales	28221|Deltaproteobacteria	T	RsbT co-antagonist protein rsbRD N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,RsbRD_N
HKD2_k127_1441983_0	1192034.CAP_5575	6.501e-100	336.0	COG0796@1|root,COG0796@2|Bacteria,1NAI2@1224|Proteobacteria,42P58@68525|delta/epsilon subdivisions,2WKYK@28221|Deltaproteobacteria,2YY1K@29|Myxococcales	28221|Deltaproteobacteria	M	Provides the (R)-glutamate required for cell wall biosynthesis	murI	-	5.1.1.3	ko:K01776	ko00471,ko01100,map00471,map01100	-	R00260	RC00302	ko00000,ko00001,ko01000,ko01011	-	-	iAF987.Gmet_0547	Asp_Glu_race
HKD2_k127_1441983_5	448385.sce6253	3.287e-36	147.0	COG2518@1|root,COG2518@2|Bacteria	2|Bacteria	O	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	-	-	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
HKD2_k127_1441983_4	1192034.CAP_6812	2.638e-37	149.0	2CH9R@1|root,33MNW@2|Bacteria,1QX99@1224|Proteobacteria,43C2G@68525|delta/epsilon subdivisions,2X7D2@28221|Deltaproteobacteria,2Z0BI@29|Myxococcales	28221|Deltaproteobacteria	M	Protein of unknown function (DUF3105)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3105
HKD2_k127_1441983_1	448385.sce3891	1.042e-74	261.0	COG3591@1|root,COG3591@2|Bacteria	2|Bacteria	E	Belongs to the peptidase S1B family	-	-	-	-	-	-	-	-	-	-	-	-	Trypsin,Trypsin_2
HKD2_k127_1441983_2	448385.sce7637	5.737e-48	177.0	COG1573@1|root,COG1573@2|Bacteria,1MWX1@1224|Proteobacteria,42QXV@68525|delta/epsilon subdivisions,2WS71@28221|Deltaproteobacteria,2Z31Q@29|Myxococcales	28221|Deltaproteobacteria	L	Uracil DNA glycosylase superfamily	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
HKD2_k127_1442379_1	448385.sce0136	3.323e-34	151.0	COG3391@1|root,COG3391@2|Bacteria,1Q2JN@1224|Proteobacteria,4386H@68525|delta/epsilon subdivisions,2X9ZH@28221|Deltaproteobacteria,2YVZH@29|Myxococcales	28221|Deltaproteobacteria	S	Beta-L-arabinofuranosidase, GH127	-	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3,Stig1
HKD2_k127_1442379_2	1278073.MYSTI_05967	1.906e-19	104.0	2AIZJ@1|root,319HM@2|Bacteria,1Q2SU@1224|Proteobacteria,438EK@68525|delta/epsilon subdivisions,2X3PJ@28221|Deltaproteobacteria,2YWS6@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Stig1
HKD2_k127_1442379_3	1229780.BN381_80254	8.326e-11	66.0	COG1404@1|root,COG5184@1|root,COG1404@2|Bacteria,COG5184@2|Bacteria,2IG31@201174|Actinobacteria	201174|Actinobacteria	DZ	PFAM regulator of chromosome condensation, RCC1	-	-	-	-	-	-	-	-	-	-	-	-	RCC1,RCC1_2,SLH
HKD2_k127_1442379_0	448385.sce1899	8.474e-35	140.0	COG2801@1|root,COG2801@2|Bacteria,1PBHA@1224|Proteobacteria,42MUE@68525|delta/epsilon subdivisions,2WJFZ@28221|Deltaproteobacteria,2YWD1@29|Myxococcales	28221|Deltaproteobacteria	L	High confidence in function and specificity	-	-	-	-	-	-	-	-	-	-	-	-	HTH_23,HTH_32,rve,rve_3
HKD2_k127_1444435_0	262724.TT_C0932	0.0005102	43.0	COG0120@1|root,COG0120@2|Bacteria,1WIR4@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	G	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate	rpiA	-	5.3.1.6	ko:K01807	ko00030,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167,M00580	R01056	RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	Rib_5-P_isom_A
HKD2_k127_1447330_2	1210884.HG799465_gene12056	1.393e-09	69.0	COG0189@1|root,COG0189@2|Bacteria	2|Bacteria	HJ	Glutathione synthase Ribosomal protein S6 modification enzyme (Glutaminyl transferase)	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1447330_0	215803.DB30_6629	1.548e-102	351.0	COG4947@1|root,COG4947@2|Bacteria,1R9C3@1224|Proteobacteria,430GQ@68525|delta/epsilon subdivisions,2WVV7@28221|Deltaproteobacteria,2YW8S@29|Myxococcales	28221|Deltaproteobacteria	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	Esterase
HKD2_k127_1447330_4	1247024.JRLH01000002_gene196	0.0006945	49.0	2DT3B@1|root,33IHT@2|Bacteria,1NK4F@1224|Proteobacteria,1SHSY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1447330_1	159087.Daro_2740	2.36e-57	204.0	COG0663@1|root,COG0663@2|Bacteria,1RD76@1224|Proteobacteria,2VR65@28216|Betaproteobacteria,2KW50@206389|Rhodocyclales	206389|Rhodocyclales	S	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep
HKD2_k127_1454845_2	1192034.CAP_7474	1.11e-41	154.0	COG0103@1|root,COG0103@2|Bacteria,1RD4A@1224|Proteobacteria,42SVI@68525|delta/epsilon subdivisions,2WP7T@28221|Deltaproteobacteria,2YV9P@29|Myxococcales	28221|Deltaproteobacteria	J	Belongs to the universal ribosomal protein uS9 family	rpsI	-	-	ko:K02996	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S9
HKD2_k127_1454845_1	448385.sce1041	3.567e-46	181.0	COG0760@1|root,COG0760@2|Bacteria,1MVB3@1224|Proteobacteria,42QXH@68525|delta/epsilon subdivisions,2WMN3@28221|Deltaproteobacteria,2YVIS@29|Myxococcales	28221|Deltaproteobacteria	M	SurA N-terminal domain	surA	-	5.2.1.8	ko:K03771	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_2,Rotamase_3,SurA_N,SurA_N_3
HKD2_k127_1454845_0	1254432.SCE1572_38605	5.513e-150	483.0	COG3825@1|root,COG3825@2|Bacteria,1MUAJ@1224|Proteobacteria,42N7R@68525|delta/epsilon subdivisions,2WJBI@28221|Deltaproteobacteria,2YU57@29|Myxococcales	28221|Deltaproteobacteria	S	VWA domain containing CoxE-like protein	-	-	-	ko:K09989	-	-	-	-	ko00000	-	-	-	VWA_CoxE
HKD2_k127_1461131_3	448385.sce3132	1.565e-72	248.0	COG0052@1|root,COG0052@2|Bacteria,1MU33@1224|Proteobacteria,42M3Y@68525|delta/epsilon subdivisions,2WJH5@28221|Deltaproteobacteria,2YTZQ@29|Myxococcales	28221|Deltaproteobacteria	J	Belongs to the universal ribosomal protein uS2 family	rpsB	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
HKD2_k127_1461131_0	1254432.SCE1572_18905	2.392e-88	301.0	COG0264@1|root,COG0264@2|Bacteria,1MUS2@1224|Proteobacteria,42NNS@68525|delta/epsilon subdivisions,2WMS3@28221|Deltaproteobacteria,2YVCJ@29|Myxococcales	28221|Deltaproteobacteria	J	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome	tsf	GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K02357	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EF_TS
HKD2_k127_1461131_2	1242864.D187_000958	1.469e-76	276.0	COG2898@1|root,COG2898@2|Bacteria,1N1JA@1224|Proteobacteria,437UA@68525|delta/epsilon subdivisions,2WYP1@28221|Deltaproteobacteria,2YU44@29|Myxococcales	28221|Deltaproteobacteria	S	Uncharacterised conserved protein (DUF2156)	-	-	2.3.2.3	ko:K14205	ko01503,ko02020,ko05150,map01503,map02020,map05150	M00726	-	-	ko00000,ko00001,ko00002,ko01000,ko01504	2.A.1.3.37	-	-	DUF2156
HKD2_k127_1461131_5	1192034.CAP_0893	1.658e-58	215.0	COG3509@1|root,COG3509@2|Bacteria,1N6M6@1224|Proteobacteria,42U8Z@68525|delta/epsilon subdivisions,2WQQT@28221|Deltaproteobacteria,2YV47@29|Myxococcales	28221|Deltaproteobacteria	Q	Esterase PHB depolymerase	-	-	-	ko:K03932	-	-	-	-	ko00000	-	CE1	-	Esterase_phd
HKD2_k127_1461131_1	448385.sce3134	1.284e-87	320.0	COG0726@1|root,COG0726@2|Bacteria,1MWYU@1224|Proteobacteria,4317N@68525|delta/epsilon subdivisions,2WWU5@28221|Deltaproteobacteria,2YV2P@29|Myxococcales	28221|Deltaproteobacteria	G	polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
HKD2_k127_1461131_4	502025.Hoch_1972	1.536e-65	244.0	COG1430@1|root,COG1430@2|Bacteria	2|Bacteria	S	Uncharacterized ACR, COG1430	-	-	-	ko:K09005	-	-	-	-	ko00000	-	-	-	DUF192
HKD2_k127_146236_3	292459.STH2507	3.764e-31	127.0	COG3596@1|root,COG3597@1|root,COG3596@2|Bacteria,COG3597@2|Bacteria,1TSZW@1239|Firmicutes,24DF6@186801|Clostridia	186801|Clostridia	S	50S ribosome-binding GTPase	-	-	-	-	-	-	-	-	-	-	-	-	DUF697,MMR_HSR1
HKD2_k127_146236_0	1254432.SCE1572_52130	6.002e-79	277.0	COG0657@1|root,COG0657@2|Bacteria,1RD8A@1224|Proteobacteria,42SS9@68525|delta/epsilon subdivisions,2WPND@28221|Deltaproteobacteria,2Z1DI@29|Myxococcales	28221|Deltaproteobacteria	I	Steryl acetyl hydrolase	-	-	3.1.1.83	ko:K14731	ko00903,ko00930,ko01220,map00903,map00930,map01220	-	R03751,R06390,R06391,R06392,R06393	RC00713,RC00983,RC01505	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_3
HKD2_k127_146236_2	448385.sce6535	6.163e-42	174.0	COG0739@1|root,COG0739@2|Bacteria,1QGHU@1224|Proteobacteria	1224|Proteobacteria	M	COG0739 Membrane proteins related to metalloendopeptidases	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
HKD2_k127_146236_1	1121946.AUAX01000010_gene3776	8.797e-59	226.0	COG0791@1|root,COG3757@1|root,COG0791@2|Bacteria,COG3757@2|Bacteria	2|Bacteria	M	lysozyme activity	-	-	3.4.17.14	ko:K07260	ko00550,ko01100,ko01502,ko02020,map00550,map01100,map01502,map02020	M00651	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504	-	-	-	Amidase_2,DUF1906,Glyco_hydro_92
HKD2_k127_146236_4	1245471.PCA10_42560	4.646e-28	122.0	COG3714@1|root,COG3714@2|Bacteria,1N6QN@1224|Proteobacteria,1SCQK@1236|Gammaproteobacteria,1YFVR@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	S	YhhN family	-	-	-	-	-	-	-	-	-	-	-	-	YhhN
HKD2_k127_1471969_2	118163.Ple7327_4274	1.267e-24	112.0	COG3548@1|root,COG3548@2|Bacteria,1G9R9@1117|Cyanobacteria	1117|Cyanobacteria	S	Integral membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF1211
HKD2_k127_1471969_3	78245.Xaut_0337	2.911e-07	56.0	2E9WT@1|root,3342I@2|Bacteria,1NBEH@1224|Proteobacteria,2UFGC@28211|Alphaproteobacteria,3F1WU@335928|Xanthobacteraceae	28211|Alphaproteobacteria	S	Putative polyhydroxyalkanoic acid system protein (PHA_gran_rgn)	MA20_00895	-	-	-	-	-	-	-	-	-	-	-	PHA_gran_rgn
HKD2_k127_1471969_1	270374.MELB17_01440	3.461e-53	198.0	COG3449@1|root,COG3449@2|Bacteria,1RF2U@1224|Proteobacteria,1S2JU@1236|Gammaproteobacteria,466VB@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	SOUL heme-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	SOUL
HKD2_k127_1471969_0	404589.Anae109_3006	6.156e-103	346.0	COG0702@1|root,COG0702@2|Bacteria,1PDTN@1224|Proteobacteria,42M8X@68525|delta/epsilon subdivisions,2WJ5J@28221|Deltaproteobacteria,2Z22B@29|Myxococcales	28221|Deltaproteobacteria	GM	NAD(P)H-binding	-	-	-	-	-	-	-	-	-	-	-	-	DUF2867,NAD_binding_10
HKD2_k127_1473729_2	1192034.CAP_7055	1.585e-141	460.0	COG1454@1|root,COG1454@2|Bacteria,1MVPH@1224|Proteobacteria,42YFS@68525|delta/epsilon subdivisions,2WUBM@28221|Deltaproteobacteria,2YU6D@29|Myxococcales	28221|Deltaproteobacteria	C	Iron-containing alcohol dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Fe-ADH
HKD2_k127_1473729_7	469383.Cwoe_4906	3.008e-43	177.0	COG0824@1|root,COG0824@2|Bacteria,2IJV6@201174|Actinobacteria	201174|Actinobacteria	S	Thioesterase	-	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT,4HBT_2
HKD2_k127_1473729_8	448385.sce6967	3.154e-25	116.0	COG2204@1|root,COG2204@2|Bacteria,1NABF@1224|Proteobacteria,43C0I@68525|delta/epsilon subdivisions,2X7B5@28221|Deltaproteobacteria,2Z3KD@29|Myxococcales	28221|Deltaproteobacteria	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
HKD2_k127_1473729_1	1254432.SCE1572_40930	1.244e-159	540.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42P6D@68525|delta/epsilon subdivisions,2WM1P@28221|Deltaproteobacteria,2YUD4@29|Myxococcales	28221|Deltaproteobacteria	T	DNA-binding response regulator	-	-	-	ko:K07713	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD2_k127_1473729_4	448385.sce6964	6.374e-88	328.0	COG4191@1|root,COG4191@2|Bacteria,1R95R@1224|Proteobacteria,42PEG@68525|delta/epsilon subdivisions,2WM8J@28221|Deltaproteobacteria,2YU43@29|Myxococcales	28221|Deltaproteobacteria	T	HAMP domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
HKD2_k127_1473729_0	1297742.A176_03031	4.526e-265	849.0	COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,42M0A@68525|delta/epsilon subdivisions,2WIQY@28221|Deltaproteobacteria,2YTUC@29|Myxococcales	28221|Deltaproteobacteria	P	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K07787,ko:K15726	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.2,2.A.6.1.4	-	-	ACR_tran
HKD2_k127_1473729_6	1123368.AUIS01000009_gene2429	1.359e-44	177.0	COG0845@1|root,COG0845@2|Bacteria,1MVAS@1224|Proteobacteria,1RPBZ@1236|Gammaproteobacteria,2NBUH@225057|Acidithiobacillales	1236|Gammaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K07798	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4,8.A.1	-	-	DUF3347,HlyD_D23,HlyD_D4,YtkA
HKD2_k127_1473729_5	1192034.CAP_5767	2.835e-49	181.0	COG0789@1|root,COG0789@2|Bacteria,1MZ3P@1224|Proteobacteria,42VYV@68525|delta/epsilon subdivisions,2WRGQ@28221|Deltaproteobacteria,2Z0X7@29|Myxococcales	28221|Deltaproteobacteria	K	MerR, DNA binding	-	-	-	ko:K19591	-	M00769	-	-	ko00000,ko00002,ko01504,ko03000	-	-	-	MerR,MerR-DNA-bind,MerR_1
HKD2_k127_1473729_3	1192034.CAP_5768	4.073e-109	366.0	COG1104@1|root,COG1104@2|Bacteria,1MU1C@1224|Proteobacteria,42M5V@68525|delta/epsilon subdivisions,2WIR6@28221|Deltaproteobacteria,2YUII@29|Myxococcales	28221|Deltaproteobacteria	H	Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins	iscS	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
HKD2_k127_1474962_3	383372.Rcas_1608	2.508e-22	100.0	COG1743@1|root,COG2852@1|root,COG1743@2|Bacteria,COG2852@2|Bacteria,2G5MZ@200795|Chloroflexi,377J3@32061|Chloroflexia	32061|Chloroflexia	L	Protein of unknown function (DUF1156)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1156
HKD2_k127_1474962_0	1071085.KK033115_gene2225	3.068e-85	301.0	COG1061@1|root,arCOG00874@2157|Archaea,2XTYQ@28890|Euryarchaeota,23SWE@183963|Halobacteria	183963|Halobacteria	K	COG1061 DNA or RNA helicases of superfamily II	rad25	-	-	-	-	-	-	-	-	-	-	-	ERCC3_RAD25_C,ResIII
HKD2_k127_1474962_2	546414.Deide_17310	5.097e-37	155.0	COG3372@1|root,COG3372@2|Bacteria	2|Bacteria	S	COGs COG3372 conserved	-	-	-	ko:K09744	-	-	-	-	ko00000	-	-	-	DUF790
HKD2_k127_1474962_1	448385.sce8981	1.329e-48	174.0	COG0667@1|root,COG0667@2|Bacteria,1MV2Y@1224|Proteobacteria,438ZR@68525|delta/epsilon subdivisions,2X8SM@28221|Deltaproteobacteria,2YY9J@29|Myxococcales	28221|Deltaproteobacteria	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
HKD2_k127_1490456_0	448385.sce7247	5.248e-271	883.0	COG0457@1|root,COG1305@1|root,COG0457@2|Bacteria,COG1305@2|Bacteria,1R5BE@1224|Proteobacteria,4339F@68525|delta/epsilon subdivisions,2WYFR@28221|Deltaproteobacteria,2YTXM@29|Myxococcales	28221|Deltaproteobacteria	E	Domain of Unknown Function with PDB structure (DUF3857)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3857,DUF3858,TPR_16,TPR_19,TPR_8,Transglut_core
HKD2_k127_1490456_1	1192034.CAP_1669	6.206e-100	335.0	COG0382@1|root,COG0382@2|Bacteria,1MXCM@1224|Proteobacteria,42PEU@68525|delta/epsilon subdivisions,2WNNT@28221|Deltaproteobacteria,2Z2ZE@29|Myxococcales	28221|Deltaproteobacteria	H	UbiA prenyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	UbiA
HKD2_k127_1490456_8	398512.JQKC01000013_gene1461	0.0002323	49.0	2ERBI@1|root,333T9@2|Bacteria,1W53V@1239|Firmicutes	1239|Firmicutes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1490456_5	1192034.CAP_1670	2.583e-63	225.0	COG1266@1|root,COG1266@2|Bacteria,1QAGW@1224|Proteobacteria,43E11@68525|delta/epsilon subdivisions,2WZDX@28221|Deltaproteobacteria,2Z1XB@29|Myxococcales	28221|Deltaproteobacteria	S	CAAX protease self-immunity	-	-	-	-	-	-	-	-	-	-	-	-	Abi
HKD2_k127_1490456_6	880073.Calab_1657	4.71e-52	203.0	COG1408@1|root,COG1408@2|Bacteria,2NRFJ@2323|unclassified Bacteria	2|Bacteria	S	Calcineurin-like phosphoesterase	-	-	-	ko:K07098	-	-	-	-	ko00000	-	-	-	Metallophos
HKD2_k127_1490456_4	448385.sce6354	3.336e-65	242.0	COG0642@1|root,COG2205@2|Bacteria	448385.sce6354|-	T	PhoQ Sensor	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1490456_2	448385.sce6353	8.869e-80	279.0	COG0745@1|root,COG0745@2|Bacteria,1MVCB@1224|Proteobacteria	1224|Proteobacteria	KT	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	chvI	GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032991,GO:0032993,GO:0043565,GO:0044212,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141	-	ko:K02483,ko:K07663,ko:K14981	ko02020,map02020	M00449,M00520	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
HKD2_k127_1490456_7	1032480.MLP_31870	2.574e-18	97.0	COG2340@1|root,COG2340@2|Bacteria,2I3XH@201174|Actinobacteria	201174|Actinobacteria	S	Cysteine-rich secretory protein family	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1490456_3	1380394.JADL01000001_gene3101	4.459e-68	246.0	COG0477@1|root,COG2814@2|Bacteria,1MVSH@1224|Proteobacteria,2TUEW@28211|Alphaproteobacteria,2JV5D@204441|Rhodospirillales	204441|Rhodospirillales	EGP	Sugar (and other) transporter	-	-	-	ko:K08151	-	M00668	-	-	ko00000,ko00002,ko01504,ko02000	2.A.1.2.38,2.A.1.2.39,2.A.1.2.4,2.A.1.2.41,2.A.1.2.68,2.A.1.2.75	-	-	MFS_1
HKD2_k127_1491727_0	1090320.KB900605_gene1571	8.419e-33	141.0	COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,2TRFB@28211|Alphaproteobacteria,2K2A4@204457|Sphingomonadales	204457|Sphingomonadales	S	Peptidase, M16	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
HKD2_k127_1491727_1	864069.MicloDRAFT_00011390	8.003e-22	100.0	2F5FH@1|root,33Y16@2|Bacteria,1NX2C@1224|Proteobacteria,2USI2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1497119_0	1192034.CAP_7500	7.348e-99	332.0	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,42NF6@68525|delta/epsilon subdivisions,2WKVH@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD2_k127_1497119_1	1254432.SCE1572_14655	3.089e-93	314.0	COG1277@1|root,COG1277@2|Bacteria,1NZZ9@1224|Proteobacteria,42SH9@68525|delta/epsilon subdivisions,2WPWW@28221|Deltaproteobacteria,2Z111@29|Myxococcales	28221|Deltaproteobacteria	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2,ABC2_membrane_3
HKD2_k127_1497119_2	448385.sce2429	4.303e-93	334.0	COG3225@1|root,COG3225@2|Bacteria,1MUXW@1224|Proteobacteria,42MRY@68525|delta/epsilon subdivisions,2WJ4F@28221|Deltaproteobacteria,2Z1RF@29|Myxococcales	28221|Deltaproteobacteria	N	ABC-type uncharacterized transport system	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2,ABC_transp_aux
HKD2_k127_1497119_4	1688.BCUN_2083	1.399e-48	178.0	COG0338@1|root,COG3392@1|root,COG0338@2|Bacteria,COG3392@2|Bacteria,2I9YW@201174|Actinobacteria,4D0ZX@85004|Bifidobacteriales	201174|Actinobacteria	L	DNA binding domain with preference for A/T rich regions	-	-	2.1.1.72	ko:K06223,ko:K07318	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko02048,ko03032,ko03400	-	-	-	MethyltransfD12
HKD2_k127_1504964_0	502025.Hoch_2647	3.42e-117	394.0	COG1716@1|root,COG3829@1|root,COG1716@2|Bacteria,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria	2|Bacteria	K	PFAM sigma-54 factor interaction domain-containing protein	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	FHA,GAF_2,HTH_8,Sigma54_activat,Yop-YscD_cpl
HKD2_k127_1504964_1	1192034.CAP_5513	1.063e-76	275.0	COG0515@1|root,COG0515@2|Bacteria	1192034.CAP_5513|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1504964_3	1450694.BTS2_3269	2.008e-07	63.0	COG5184@1|root,COG5184@2|Bacteria,1UWIF@1239|Firmicutes,4I683@91061|Bacilli,1ZEHV@1386|Bacillus	91061|Bacilli	DZ	Cadherin-like beta sandwich domain	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin-like
HKD2_k127_151042_0	391625.PPSIR1_21914	1.098e-75	280.0	COG0515@1|root,COG0515@2|Bacteria	391625.PPSIR1_21914|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_151042_1	580332.Slit_2775	5.105e-60	224.0	COG1028@1|root,COG1028@2|Bacteria,1P9R4@1224|Proteobacteria,2VUQP@28216|Betaproteobacteria	28216|Betaproteobacteria	IQ	PFAM Short-chain dehydrogenase reductase SDR	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HKD2_k127_151042_2	215803.DB30_3254	5.418e-12	66.0	COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,438S3@68525|delta/epsilon subdivisions,2X3YW@28221|Deltaproteobacteria,2YXN3@29|Myxococcales	28221|Deltaproteobacteria	T	GAF domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA
HKD2_k127_1512432_1	1254432.SCE1572_10470	1.477e-12	80.0	COG2185@1|root,COG2185@2|Bacteria,1RKGS@1224|Proteobacteria,42SKV@68525|delta/epsilon subdivisions,2WP2X@28221|Deltaproteobacteria,2YV7A@29|Myxococcales	28221|Deltaproteobacteria	I	B12 binding domain	-	-	5.4.99.2	ko:K01849	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding
HKD2_k127_1512432_0	483219.LILAB_08090	2.776e-26	123.0	COG2843@1|root,COG2843@2|Bacteria,1P1MG@1224|Proteobacteria,42QJH@68525|delta/epsilon subdivisions,2X5XR@28221|Deltaproteobacteria,2YZP4@29|Myxococcales	28221|Deltaproteobacteria	M	Bacterial capsule synthesis protein PGA_cap	-	-	-	ko:K07282	-	-	-	-	ko00000	-	-	-	PGA_cap
HKD2_k127_1514475_3	1242864.D187_009577	2.126e-92	310.0	COG0258@1|root,COG0258@2|Bacteria,1QV40@1224|Proteobacteria,43BZM@68525|delta/epsilon subdivisions,2X7AE@28221|Deltaproteobacteria,2YUE3@29|Myxococcales	28221|Deltaproteobacteria	L	Helix-hairpin-helix class 2 (Pol1 family) motifs	-	-	-	-	-	-	-	-	-	-	-	-	5_3_exonuc,5_3_exonuc_N
HKD2_k127_1514475_4	448385.sce2076	1.658e-51	206.0	2A42Z@1|root,30SMX@2|Bacteria,1PBWJ@1224|Proteobacteria,4385D@68525|delta/epsilon subdivisions,2X3FD@28221|Deltaproteobacteria,2YVUP@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1514475_2	1192034.CAP_4902	1.213e-123	407.0	COG1448@1|root,COG1448@2|Bacteria	2|Bacteria	E	Aminotransferase	tyrB	GO:0003674,GO:0003824,GO:0004069,GO:0004838,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006531,GO:0006532,GO:0006551,GO:0006558,GO:0006570,GO:0006571,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0008793,GO:0009058,GO:0009066,GO:0009067,GO:0009072,GO:0009073,GO:0009081,GO:0009082,GO:0009094,GO:0009095,GO:0009098,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0017144,GO:0019292,GO:0019438,GO:0019752,GO:0019842,GO:0030170,GO:0033585,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050048,GO:0050662,GO:0070279,GO:0070547,GO:0071704,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902221,GO:1902223	2.6.1.1,2.6.1.57	ko:K00813,ko:K00832	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	M00024,M00025,M00034,M00040	R00355,R00694,R00734,R00896,R01731,R02433,R02619,R05052,R07396,R10845	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	iECED1_1282.ECED1_4768,iECSE_1348.ECSE_4347,iJN746.PP_3590,iLF82_1304.LF82_2339,iNRG857_1313.NRG857_20250,iPC815.YPO1410,iSFxv_1172.SFxv_1000,iUTI89_1310.UTI89_C4629	Aminotran_1_2
HKD2_k127_1514475_1	1254432.SCE1572_33330	4.148e-143	465.0	COG1752@1|root,COG1752@2|Bacteria,1PEH4@1224|Proteobacteria,42XKH@68525|delta/epsilon subdivisions,2WTA6@28221|Deltaproteobacteria,2YUHG@29|Myxococcales	28221|Deltaproteobacteria	S	Patatin-like phospholipase	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
HKD2_k127_1514475_6	215803.DB30_1991	2.427e-08	64.0	2AGCS@1|root,316IF@2|Bacteria,1PXN9@1224|Proteobacteria,43EI7@68525|delta/epsilon subdivisions,2WZ12@28221|Deltaproteobacteria,2Z139@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1514475_5	1122951.ATUE01000005_gene1747	8.672e-25	105.0	COG0695@1|root,COG0695@2|Bacteria,1N72P@1224|Proteobacteria,1SCA2@1236|Gammaproteobacteria,3NNVE@468|Moraxellaceae	1236|Gammaproteobacteria	O	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins	grxC	-	-	ko:K03676	-	-	-	-	ko00000,ko03110	-	-	-	Glutaredoxin
HKD2_k127_1514475_0	448385.sce7923	1.107e-158	519.0	COG0542@1|root,COG0542@2|Bacteria,1MURH@1224|Proteobacteria,42M9S@68525|delta/epsilon subdivisions,2WJSZ@28221|Deltaproteobacteria,2YUBF@29|Myxococcales	28221|Deltaproteobacteria	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpB	-	-	ko:K03695	ko04213,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
HKD2_k127_1515085_8	316055.RPE_3952	3.254e-67	236.0	COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,2TS3W@28211|Alphaproteobacteria,3JWVM@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner	lolD1	-	-	ko:K02003,ko:K09810	ko02010,map02010	M00255,M00258	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.125	-	-	ABC_tran
HKD2_k127_1515085_0	448385.sce1111	3.055e-162	522.0	COG4591@1|root,COG4591@2|Bacteria,1MVV7@1224|Proteobacteria,42MV0@68525|delta/epsilon subdivisions,2WITK@28221|Deltaproteobacteria,2YTZ7@29|Myxococcales	28221|Deltaproteobacteria	M	MacB-like periplasmic core domain	-	-	-	ko:K09808	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.125	-	-	FtsX,MacB_PCD
HKD2_k127_1515085_1	448385.sce1110	3.406e-146	473.0	COG0845@1|root,COG0845@2|Bacteria,1MXGH@1224|Proteobacteria,42M4G@68525|delta/epsilon subdivisions,2X36X@28221|Deltaproteobacteria,2YUQM@29|Myxococcales	28221|Deltaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	HlyD_D23
HKD2_k127_1515085_2	1254432.SCE1572_20750	3.386e-112	400.0	COG5002@1|root,COG5002@2|Bacteria,1MWF3@1224|Proteobacteria,42NB5@68525|delta/epsilon subdivisions,2WJGX@28221|Deltaproteobacteria,2YY2P@29|Myxococcales	28221|Deltaproteobacteria	T	Histidine kinase	phoR	-	2.7.13.3	ko:K07636	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_8,sCache_like
HKD2_k127_1515085_6	1254432.SCE1572_30820	4.045e-81	276.0	COG0745@1|root,COG0745@2|Bacteria,1MY2Z@1224|Proteobacteria,42MP1@68525|delta/epsilon subdivisions,2WJPD@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	PFAM response regulator receiver	phoB	-	-	ko:K07657	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
HKD2_k127_1515085_3	1254432.SCE1572_40750	1.102e-95	326.0	COG0196@1|root,COG0196@2|Bacteria,1MV9I@1224|Proteobacteria,42MV7@68525|delta/epsilon subdivisions,2WJTU@28221|Deltaproteobacteria,2YV5E@29|Myxococcales	28221|Deltaproteobacteria	H	Belongs to the ribF family	ribF	-	2.7.1.26,2.7.7.2	ko:K11753	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00161,R00549	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_syn,Flavokinase
HKD2_k127_1515085_4	1192034.CAP_4019	1.797e-92	314.0	COG1466@1|root,COG1466@2|Bacteria,1RHE9@1224|Proteobacteria,42SNR@68525|delta/epsilon subdivisions,2WP96@28221|Deltaproteobacteria,2Z1UE@29|Myxococcales	28221|Deltaproteobacteria	L	DNA polymerase III, delta subunit	holA	-	2.7.7.7	ko:K02340	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta
HKD2_k127_1515085_9	448385.sce8066	5.522e-53	203.0	COG2885@1|root,COG2885@2|Bacteria,1R7WJ@1224|Proteobacteria,42QJK@68525|delta/epsilon subdivisions,2WJX0@28221|Deltaproteobacteria,2Z2YX@29|Myxococcales	28221|Deltaproteobacteria	M	Belongs to the ompA family	-	-	-	-	-	-	-	-	-	-	-	-	OmpA,TSP_3
HKD2_k127_1515085_12	448385.sce0136	0.0004823	52.0	COG3391@1|root,COG3391@2|Bacteria,1Q2JN@1224|Proteobacteria,4386H@68525|delta/epsilon subdivisions,2X9ZH@28221|Deltaproteobacteria,2YVZH@29|Myxococcales	28221|Deltaproteobacteria	S	Beta-L-arabinofuranosidase, GH127	-	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3,Stig1
HKD2_k127_1515085_5	861299.J421_3940	3.673e-88	305.0	COG2211@1|root,COG2211@2|Bacteria	2|Bacteria	G	Major facilitator Superfamily	-	-	-	ko:K08223	-	-	-	-	ko00000,ko02000	2.A.1.35	-	-	MFS_1,Sugar_tr
HKD2_k127_1515085_7	1192034.CAP_4004	3.529e-74	257.0	COG0807@1|root,COG0807@2|Bacteria,1MWZR@1224|Proteobacteria,42N2Q@68525|delta/epsilon subdivisions,2X9TY@28221|Deltaproteobacteria,2Z0GS@29|Myxococcales	28221|Deltaproteobacteria	F	Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate	ribA	-	3.5.4.25	ko:K01497	ko00740,ko00790,ko01100,ko01110,ko02024,map00740,map00790,map01100,map01110,map02024	M00125	R00425	RC00293,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	-	GTP_cyclohydro2
HKD2_k127_1516038_4	1192034.CAP_2242	5.907e-62	232.0	COG2755@1|root,COG2755@2|Bacteria,1MXSG@1224|Proteobacteria,43476@68525|delta/epsilon subdivisions,2X9U4@28221|Deltaproteobacteria,2YV4A@29|Myxococcales	28221|Deltaproteobacteria	E	COG2755 Lysophospholipase L1 and related esterases	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
HKD2_k127_1516038_0	378806.STAUR_0788	6.777e-198	660.0	COG1073@1|root,COG1073@2|Bacteria,1NVTC@1224|Proteobacteria,42Z2F@68525|delta/epsilon subdivisions,2WTUN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	COG1073 hydrolases of the alpha beta superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_bact_N
HKD2_k127_1516038_3	1144275.COCOR_00367	1.168e-78	287.0	COG2067@1|root,COG2067@2|Bacteria,1MUU4@1224|Proteobacteria,42N9J@68525|delta/epsilon subdivisions,2WK7H@28221|Deltaproteobacteria,2YXMU@29|Myxococcales	28221|Deltaproteobacteria	I	Long-chain fatty acid transport protein	-	-	-	ko:K06076	-	-	-	-	ko00000,ko02000	1.B.9	-	-	Toluene_X
HKD2_k127_1516038_1	378806.STAUR_6873	5.075e-164	521.0	COG1741@1|root,COG1741@2|Bacteria,1MWIP@1224|Proteobacteria,42UHA@68525|delta/epsilon subdivisions,2WQA0@28221|Deltaproteobacteria,2YUHZ@29|Myxococcales	28221|Deltaproteobacteria	S	Belongs to the pirin family	-	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin,Pirin_C
HKD2_k127_1516038_2	1254432.SCE1572_37585	1.572e-100	349.0	COG2755@1|root,COG2755@2|Bacteria,1MXSG@1224|Proteobacteria,43476@68525|delta/epsilon subdivisions,2X9U4@28221|Deltaproteobacteria,2YV4A@29|Myxococcales	28221|Deltaproteobacteria	E	COG2755 Lysophospholipase L1 and related esterases	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
HKD2_k127_1516038_5	448385.sce3538	2.045e-54	216.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria	1224|Proteobacteria	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HKD2_k127_1516038_7	448385.sce3538	2.324e-53	207.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria	1224|Proteobacteria	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HKD2_k127_1516038_6	706587.Desti_5519	4.098e-54	198.0	COG0172@1|root,COG0172@2|Bacteria,1MUJF@1224|Proteobacteria,42M7H@68525|delta/epsilon subdivisions,2WIT7@28221|Deltaproteobacteria,2MQ90@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iAF987.Gmet_3528	Seryl_tRNA_N,tRNA-synt_2b
HKD2_k127_1519780_0	1187851.A33M_3196	1.094e-86	295.0	COG1775@1|root,COG1775@2|Bacteria,1NNW9@1224|Proteobacteria,2U2IH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	benzoyl-CoA reductase	-	-	1.3.7.8	ko:K04112	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00541	R02451	RC00002,RC01839	ko00000,ko00001,ko00002,ko01000	-	-	-	HGD-D
HKD2_k127_1519780_1	1187851.A33M_3197	7.389e-66	244.0	COG1775@1|root,COG1775@2|Bacteria,1NKED@1224|Proteobacteria,2U31W@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	benzoyl-CoA reductase	-	-	1.3.7.8	ko:K04113	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00541	R02451	RC00002,RC01839	ko00000,ko00001,ko00002,ko01000	-	-	-	HGD-D
HKD2_k127_1525368_1	1134474.O59_000004	5.762e-48	192.0	COG3757@1|root,COG3757@2|Bacteria,1N792@1224|Proteobacteria,1S6KA@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	glycoside hydrolase, family	-	-	-	ko:K07273	-	-	-	-	ko00000	-	-	-	Glyco_hydro_25
HKD2_k127_1525368_0	483219.LILAB_06290	2.074e-132	456.0	2EGHW@1|root,33A9Z@2|Bacteria,1PM4Y@1224|Proteobacteria,43304@68525|delta/epsilon subdivisions,2WYJA@28221|Deltaproteobacteria,2Z1SV@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1525368_2	448385.sce7211	2.372e-43	158.0	COG0347@1|root,COG0347@2|Bacteria,1RGWK@1224|Proteobacteria,42SJJ@68525|delta/epsilon subdivisions,2WP4E@28221|Deltaproteobacteria,2YVH0@29|Myxococcales	28221|Deltaproteobacteria	K	Belongs to the P(II) protein family	glnB	-	-	ko:K04751	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	P-II
HKD2_k127_1525905_1	316274.Haur_4037	1.495e-64	232.0	COG0598@1|root,COG0598@2|Bacteria,2G6EQ@200795|Chloroflexi,375MB@32061|Chloroflexia	32061|Chloroflexia	P	Mediates influx of magnesium ions	corA	-	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
HKD2_k127_1525905_3	1121377.KB906412_gene739	3.297e-52	194.0	COG0122@1|root,COG0122@2|Bacteria	2|Bacteria	L	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase	-	-	3.2.2.21	ko:K01247	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
HKD2_k127_1525905_4	448385.sce1330	1.238e-31	142.0	COG0612@1|root,COG0612@2|Bacteria,1MU6R@1224|Proteobacteria,42M74@68525|delta/epsilon subdivisions,2WNZ3@28221|Deltaproteobacteria,2YUQW@29|Myxococcales	28221|Deltaproteobacteria	S	Insulinase (Peptidase family M16)	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
HKD2_k127_1525905_2	1192034.CAP_5905	3.793e-53	205.0	COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,42PZF@68525|delta/epsilon subdivisions,2X5HR@28221|Deltaproteobacteria,2Z35T@29|Myxococcales	28221|Deltaproteobacteria	S	Insulinase (Peptidase family M16)	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
HKD2_k127_1525905_0	1192034.CAP_0605	1.13e-162	518.0	COG1034@1|root,COG1034@2|Bacteria,1P8MN@1224|Proteobacteria,42PT5@68525|delta/epsilon subdivisions,2WKMJ@28221|Deltaproteobacteria,2YU8F@29|Myxococcales	28221|Deltaproteobacteria	C	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region	nuoG	-	1.6.5.3	ko:K00336	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer2_4,Molybdop_Fe4S4,Molybdopterin,NADH-G_4Fe-4S_3
HKD2_k127_1531554_4	1192034.CAP_4069	5.702e-74	256.0	COG0515@1|root,COG0515@2|Bacteria	1192034.CAP_4069|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1531554_6	502025.Hoch_5289	1.295e-06	59.0	2AH4J@1|root,317E7@2|Bacteria,1PYQD@1224|Proteobacteria,435HH@68525|delta/epsilon subdivisions,2WZV3@28221|Deltaproteobacteria,2Z2TC@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1531554_0	448385.sce5469	2.054e-189	601.0	COG1716@1|root,COG2204@1|root,COG1716@2|Bacteria,COG2204@2|Bacteria	2|Bacteria	T	phosphorelay signal transduction system	-	-	4.6.1.1	ko:K01768,ko:K10941,ko:K11894	ko00230,ko02020,ko02025,ko04113,ko04213,ko05111,map00230,map02020,map02025,map04113,map04213,map05111	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000,ko02044,ko03000	3.A.23.1	-	-	FHA,GAF_2,HTH_8,Sigma54_activat,Yop-YscD_cpl
HKD2_k127_1531554_2	1254432.SCE1572_07800	8.033e-135	446.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,42Q67@68525|delta/epsilon subdivisions,2WKZ1@28221|Deltaproteobacteria,2YZ6I@29|Myxococcales	28221|Deltaproteobacteria	KLT	Serine Threonine protein kinase	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HKD2_k127_1531554_1	448385.sce1088	9.285e-138	454.0	COG4591@1|root,COG4591@2|Bacteria,1MVV7@1224|Proteobacteria,42MV0@68525|delta/epsilon subdivisions,2WITK@28221|Deltaproteobacteria,2YUSA@29|Myxococcales	28221|Deltaproteobacteria	M	ABC-type transport system involved in lipoprotein release permease component	lolC	-	-	ko:K09808	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.125	-	-	FtsX,MacB_PCD
HKD2_k127_1543461_3	1254432.SCE1572_02460	4.557e-104	356.0	COG0515@1|root,COG2203@1|root,COG2204@1|root,COG2909@1|root,COG0515@2|Bacteria,COG2203@2|Bacteria,COG2204@2|Bacteria,COG2909@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions	1224|Proteobacteria	T	two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HTH_8,Pkinase,Sigma54_activat,TPR_12
HKD2_k127_1543461_2	1192034.CAP_5830	7.558e-105	354.0	COG2267@1|root,COG2267@2|Bacteria,1QDPV@1224|Proteobacteria,433U2@68525|delta/epsilon subdivisions,2X3GG@28221|Deltaproteobacteria,2YVZT@29|Myxococcales	28221|Deltaproteobacteria	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Hydrolase_4
HKD2_k127_1543461_4	1254432.SCE1572_18155	8.82e-101	352.0	COG1858@1|root,COG3391@1|root,COG1858@2|Bacteria,COG3391@2|Bacteria,1PCDK@1224|Proteobacteria,438DK@68525|delta/epsilon subdivisions,2X3NQ@28221|Deltaproteobacteria,2YWPI@29|Myxococcales	28221|Deltaproteobacteria	C	cytochrome C peroxidase	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C
HKD2_k127_1543461_0	926549.KI421517_gene109	1.375e-130	428.0	COG0477@1|root,COG2814@2|Bacteria,4NEQU@976|Bacteroidetes,47KKT@768503|Cytophagia	976|Bacteroidetes	EGP	Major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD2_k127_1543461_1	1121920.AUAU01000010_gene55	8.598e-106	347.0	COG1131@1|root,COG1131@2|Bacteria,3Y394@57723|Acidobacteria	57723|Acidobacteria	V	PFAM ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD2_k127_1543461_6	1192034.CAP_1726	9.799e-67	238.0	COG2267@1|root,COG2267@2|Bacteria,1NYNM@1224|Proteobacteria,43CA0@68525|delta/epsilon subdivisions,2X7KG@28221|Deltaproteobacteria,2YVW6@29|Myxococcales	28221|Deltaproteobacteria	I	alpha/beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
HKD2_k127_1543461_8	639030.JHVA01000001_gene11	2.559e-34	148.0	COG0845@1|root,COG0845@2|Bacteria,3Y32U@57723|Acidobacteria,2JI2W@204432|Acidobacteriia	204432|Acidobacteriia	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_D23
HKD2_k127_1543461_7	330214.NIDE0726	1.63e-34	149.0	COG0841@1|root,COG0841@2|Bacteria,3J0ZG@40117|Nitrospirae	40117|Nitrospirae	V	AcrB/AcrD/AcrF family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
HKD2_k127_1543505_0	1458275.AZ34_09505	2.198e-107	357.0	COG2084@1|root,COG2084@2|Bacteria,1MV48@1224|Proteobacteria,2VKTQ@28216|Betaproteobacteria,4ABGJ@80864|Comamonadaceae	28216|Betaproteobacteria	I	PFAM 6-phosphogluconate dehydrogenase NAD-binding	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_11,NAD_binding_2
HKD2_k127_1543505_1	1280390.CBQR020000086_gene1885	4.113e-71	265.0	COG0451@1|root,COG0451@2|Bacteria,1TR3K@1239|Firmicutes,4HD3P@91061|Bacilli,26V3Z@186822|Paenibacillaceae	91061|Bacilli	GM	COG0451 Nucleoside-diphosphate-sugar epimerases	-	-	1.3.1.45	ko:K05281	ko00943,ko01110,map00943,map01110	-	R06562,R06563,R07747,R07751	RC00805	ko00000,ko00001,ko01000	-	-	-	Epimerase
HKD2_k127_1543505_2	157783.LK03_16850	9.304e-32	132.0	COG0483@1|root,COG0483@2|Bacteria,1PPJ0@1224|Proteobacteria,1S0BD@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	inositol monophosphatase	-	-	3.1.3.15,3.1.3.25	ko:K01092,ko:K05602	ko00340,ko00521,ko00562,ko01100,ko01110,ko01230,ko04070,map00340,map00521,map00562,map01100,map01110,map01230,map04070	M00026,M00131	R01185,R01186,R01187,R03013	RC00017,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
HKD2_k127_1551583_3	7370.XP_005191981.1	0.0004732	49.0	COG1404@1|root,KOG3525@2759|Eukaryota,38C1N@33154|Opisthokonta,3B9FW@33208|Metazoa,3CR8X@33213|Bilateria,41TDC@6656|Arthropoda,3SHTA@50557|Insecta,4554F@7147|Diptera	33208|Metazoa	O	Furin-like repeats	Fur2	GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005623,GO:0005886,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016020,GO:0016787,GO:0017171,GO:0019538,GO:0032879,GO:0043170,GO:0044238,GO:0044464,GO:0048519,GO:0050789,GO:0051046,GO:0051048,GO:0051049,GO:0051051,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564	3.4.21.75	ko:K01349,ko:K08654	ko05164,map05164	-	-	-	ko00000,ko00001,ko01000,ko01002,ko03110,ko04131	-	-	-	Furin-like_2,GF_recep_IV,P_proprotein,Peptidase_S8,S8_pro-domain
HKD2_k127_1551583_4	1192034.CAP_2841	0.0005894	52.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1551583_2	1267533.KB906735_gene4931	2.063e-08	64.0	COG1032@1|root,COG1032@2|Bacteria,3Y7D8@57723|Acidobacteria,2JMKA@204432|Acidobacteriia	204432|Acidobacteriia	C	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
HKD2_k127_1551583_0	290397.Adeh_3883	1.156e-35	147.0	COG1032@1|root,COG1032@2|Bacteria,1MWR0@1224|Proteobacteria,42PFW@68525|delta/epsilon subdivisions,2WJ1N@28221|Deltaproteobacteria,2Z1PP@29|Myxococcales	28221|Deltaproteobacteria	C	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM,TPR_14,TPR_16
HKD2_k127_1551583_1	448385.sce7390	6.565e-14	72.0	COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,42MFT@68525|delta/epsilon subdivisions,2WIXC@28221|Deltaproteobacteria,2YWED@29|Myxococcales	28221|Deltaproteobacteria	U	Ammonium Transporter Family	amtB	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
HKD2_k127_1561598_8	326427.Cagg_3190	3.194e-71	245.0	COG0364@1|root,COG0364@2|Bacteria,2G5MB@200795|Chloroflexi,374UD@32061|Chloroflexia	32061|Chloroflexia	G	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone	zwf	-	1.1.1.363,1.1.1.49	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	M00004,M00006,M00008	R00835,R02736,R10907	RC00001,RC00066	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	G6PD_C,G6PD_N
HKD2_k127_1561598_15	321327.CYA_0388	4.197e-23	115.0	COG3429@1|root,COG3429@2|Bacteria,1G2UB@1117|Cyanobacteria,1GYQU@1129|Synechococcus	1117|Cyanobacteria	G	glucose 6-phosphate dehydrogenase	opcA	-	-	-	-	-	-	-	-	-	-	-	OpcA_G6PD_assem,PG_binding_1
HKD2_k127_1561598_11	329726.AM1_2637	2.738e-44	172.0	COG0363@1|root,COG0363@2|Bacteria,1G20H@1117|Cyanobacteria	1117|Cyanobacteria	G	6-phosphogluconolactonase	pgl	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009051,GO:0009117,GO:0009987,GO:0016787,GO:0016788,GO:0017057,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046496,GO:0051156,GO:0051186,GO:0052689,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564	3.1.1.31	ko:K01057	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200	M00004,M00006,M00008	R02035	RC00537	ko00000,ko00001,ko00002,ko01000	-	-	-	Glucosamine_iso
HKD2_k127_1561598_10	748247.AZKH_2969	7.436e-52	201.0	COG1801@1|root,COG1801@2|Bacteria,1MU7F@1224|Proteobacteria,2VJ9S@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Protein of unknown function DUF72	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
HKD2_k127_1561598_0	309807.SRU_0275	4.784e-212	681.0	COG0021@1|root,COG0021@2|Bacteria,4P14U@976|Bacteroidetes,1FIXF@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	G	Transketolase, thiamine diphosphate binding domain	tkt	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
HKD2_k127_1561598_6	1192034.CAP_8243	9.298e-91	314.0	COG1559@1|root,COG1559@2|Bacteria,1MUQF@1224|Proteobacteria,42MPA@68525|delta/epsilon subdivisions,2WJ0Q@28221|Deltaproteobacteria,2YVDN@29|Myxococcales	28221|Deltaproteobacteria	S	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation	mltG	-	-	ko:K07082	-	-	-	-	ko00000	-	-	-	YceG
HKD2_k127_1561598_12	1254432.SCE1572_27680	2.241e-33	146.0	COG0816@1|root,COG0816@2|Bacteria,1RDHZ@1224|Proteobacteria,42UC6@68525|delta/epsilon subdivisions,2WPDD@28221|Deltaproteobacteria,2YVEN@29|Myxococcales	28221|Deltaproteobacteria	J	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA	-	-	-	ko:K07447	-	-	-	-	ko00000,ko01000	-	-	-	RuvX
HKD2_k127_1561598_3	1192034.CAP_4332	8.189e-156	502.0	COG0124@1|root,COG0124@2|Bacteria,1MV2K@1224|Proteobacteria,42MG0@68525|delta/epsilon subdivisions,2WJE1@28221|Deltaproteobacteria,2YTVY@29|Myxococcales	28221|Deltaproteobacteria	J	histidyl-tRNA synthetase	hisS	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
HKD2_k127_1561598_4	1192034.CAP_4333	1.082e-101	369.0	COG3170@1|root,COG3170@2|Bacteria	2|Bacteria	NU	translation initiation factor activity	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	-
HKD2_k127_1561598_5	448385.sce3703	1.133e-101	347.0	COG1104@1|root,COG1104@2|Bacteria,1MU1C@1224|Proteobacteria	1224|Proteobacteria	E	Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins	-	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
HKD2_k127_1561598_7	1192034.CAP_2241	2.189e-73	271.0	COG1572@1|root,COG1572@2|Bacteria	2|Bacteria	NU	bacterial-type flagellum-dependent cell motility	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,CARDB,F5_F8_type_C,SdrD_B
HKD2_k127_1561598_9	290397.Adeh_2669	1.177e-64	228.0	COG3000@1|root,COG3000@2|Bacteria,1R4RM@1224|Proteobacteria,43F3R@68525|delta/epsilon subdivisions,2X3A7@28221|Deltaproteobacteria,2YV37@29|Myxococcales	28221|Deltaproteobacteria	I	fatty acid hydroxylase	-	-	-	-	-	-	-	-	-	-	-	-	FA_hydroxylase
HKD2_k127_1561598_2	1192034.CAP_7076	4.924e-166	531.0	COG0642@1|root,COG0784@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,439TT@68525|delta/epsilon subdivisions,2X575@28221|Deltaproteobacteria,2Z07H@29|Myxococcales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg
HKD2_k127_1561598_13	1192034.CAP_6956	1.371e-27	129.0	COG0545@1|root,COG0545@2|Bacteria,1RDA1@1224|Proteobacteria,42TNB@68525|delta/epsilon subdivisions,2WQIG@28221|Deltaproteobacteria,2Z0TE@29|Myxococcales	28221|Deltaproteobacteria	O	FKBP-type peptidyl-prolyl cis-trans isomerase	-	-	5.2.1.8	ko:K01802,ko:K03772	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	FKBP_C
HKD2_k127_1561598_14	1234364.AMSF01000055_gene1106	1.935e-26	113.0	COG0643@1|root,COG0745@1|root,COG2198@1|root,COG0643@2|Bacteria,COG0745@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,1RMS6@1236|Gammaproteobacteria,1X3AY@135614|Xanthomonadales	135614|Xanthomonadales	T	Chemotaxis protein histidine kinase and related kinases	pilL	-	-	ko:K02487,ko:K06596	ko02020,ko02025,map02020,map02025	M00507	-	-	ko00000,ko00001,ko00002,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg
HKD2_k127_1561598_1	1192034.CAP_7078	8.842e-167	540.0	COG0815@1|root,COG0815@2|Bacteria,1MUBU@1224|Proteobacteria,42MPS@68525|delta/epsilon subdivisions,2WIUD@28221|Deltaproteobacteria,2YVAG@29|Myxococcales	28221|Deltaproteobacteria	M	Transfers the fatty acyl group on membrane lipoproteins	lnt	-	-	ko:K03820	-	-	-	-	ko00000,ko01000	-	GT2	-	CN_hydrolase
HKD2_k127_1562324_1	1396418.BATQ01000072_gene567	1.449e-157	544.0	COG0542@1|root,COG0542@2|Bacteria,46S4S@74201|Verrucomicrobia,2ITN7@203494|Verrucomicrobiae	203494|Verrucomicrobiae	O	C-terminal, D2-small domain, of ClpB protein	-	-	-	-	-	-	-	-	-	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
HKD2_k127_1562324_5	391625.PPSIR1_41869	2.501e-45	180.0	COG0515@1|root,COG4753@1|root,COG0515@2|Bacteria,COG4753@2|Bacteria,1QYCW@1224|Proteobacteria,43CBA@68525|delta/epsilon subdivisions	1224|Proteobacteria	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,SpoIIE
HKD2_k127_1562324_11	945713.IALB_0955	2.876e-05	57.0	COG5513@1|root,COG5513@2|Bacteria	2|Bacteria	G	serine-type aminopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF3298,DUF4163
HKD2_k127_1562324_4	305700.B447_10433	4.611e-54	212.0	COG3332@1|root,COG3332@2|Bacteria,1RDBS@1224|Proteobacteria,2VQK6@28216|Betaproteobacteria,2KW9M@206389|Rhodocyclales	206389|Rhodocyclales	S	Transport and Golgi organisation 2	-	-	-	-	-	-	-	-	-	-	-	-	TANGO2
HKD2_k127_1562324_7	987059.RBXJA2T_14166	1.185e-28	130.0	COG2199@1|root,COG3706@2|Bacteria,1MV4X@1224|Proteobacteria,2VMRS@28216|Betaproteobacteria,1KPF9@119065|unclassified Burkholderiales	28216|Betaproteobacteria	T	diguanylate cyclase	ydaM_1	-	2.7.7.65	ko:K21020	ko02025,map02025	-	-	-	ko00000,ko00001,ko01000	-	-	-	GGDEF
HKD2_k127_1562324_10	1068978.AMETH_1047	1.231e-08	68.0	2DQF9@1|root,336H4@2|Bacteria,2GSTY@201174|Actinobacteria,4ECES@85010|Pseudonocardiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1562324_0	745310.G432_00945	3.624e-179	569.0	COG0446@1|root,COG0446@2|Bacteria,1NR3M@1224|Proteobacteria,2TS0K@28211|Alphaproteobacteria,2K12H@204457|Sphingomonadales	204457|Sphingomonadales	S	pyridine nucleotide-disulfide oxidoreductase	-	-	1.18.1.3	ko:K00529	ko00071,ko00360,ko01120,ko01220,map00071,map00360,map01120,map01220	M00545	R02000,R06782,R06783	RC00098	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	Pyr_redox_2,Reductase_C
HKD2_k127_1562324_3	1192034.CAP_7390	2.449e-98	332.0	COG0225@1|root,COG0225@2|Bacteria,1MVUS@1224|Proteobacteria,43BC6@68525|delta/epsilon subdivisions,2X5GM@28221|Deltaproteobacteria,2YU51@29|Myxococcales	28221|Deltaproteobacteria	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	msrA	-	1.8.4.11	ko:K07304	-	-	-	-	ko00000,ko01000	-	-	-	PMSR
HKD2_k127_1562324_2	1254432.SCE1572_42540	4.027e-111	373.0	COG0644@1|root,COG0644@2|Bacteria,1MZVI@1224|Proteobacteria,43ENH@68525|delta/epsilon subdivisions,2X242@28221|Deltaproteobacteria,2Z170@29|Myxococcales	28221|Deltaproteobacteria	C	Tryptophan halogenase	-	-	-	-	-	-	-	-	-	-	-	-	Trp_halogenase
HKD2_k127_1562324_8	1283299.AUKG01000002_gene3945	4.324e-24	106.0	COG2267@1|root,COG2267@2|Bacteria,2I2IM@201174|Actinobacteria,4CQH4@84995|Rubrobacteria	84995|Rubrobacteria	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
HKD2_k127_1576626_1	448385.sce0123	1.479e-48	185.0	COG0589@1|root,COG0589@2|Bacteria,1MVZS@1224|Proteobacteria,42QGY@68525|delta/epsilon subdivisions,2WKHR@28221|Deltaproteobacteria,2Z0V8@29|Myxococcales	28221|Deltaproteobacteria	T	Belongs to the universal stress protein A family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD2_k127_1576626_0	314345.SPV1_00345	1.829e-271	863.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria	1224|Proteobacteria	P	ATPase, P-type transporting, HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
HKD2_k127_1576626_2	448385.sce3269	0.0001491	49.0	COG3004@1|root,COG3004@2|Bacteria,1MW15@1224|Proteobacteria,42MBN@68525|delta/epsilon subdivisions,2WINT@28221|Deltaproteobacteria,2YUPM@29|Myxococcales	28221|Deltaproteobacteria	P	) H( ) antiporter that extrudes sodium in exchange for external protons	nhaA	-	-	ko:K03313	-	-	-	-	ko00000,ko02000	2.A.33.1	-	-	Na_H_antiport_1
HKD2_k127_1579342_1	1254432.SCE1572_52020	1.694e-47	179.0	COG1335@1|root,COG1335@2|Bacteria,1MU5N@1224|Proteobacteria,42RN4@68525|delta/epsilon subdivisions,2WP37@28221|Deltaproteobacteria,2YVD3@29|Myxococcales	28221|Deltaproteobacteria	Q	Isochorismatase family	-	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
HKD2_k127_1579342_3	1394178.AWOO02000023_gene5478	5.156e-05	53.0	2CDI5@1|root,2Z7ZQ@2|Bacteria,2I8FG@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1579342_2	215803.DB30_4994	1.035e-16	86.0	COG3411@1|root,COG3411@2|Bacteria,1RM68@1224|Proteobacteria,42TUK@68525|delta/epsilon subdivisions,2WQGU@28221|Deltaproteobacteria,2YVQK@29|Myxococcales	28221|Deltaproteobacteria	C	Ferredoxin	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1579342_0	1192034.CAP_2166	8.399e-92	302.0	COG2987@1|root,COG2987@2|Bacteria,1MU4W@1224|Proteobacteria,42PUK@68525|delta/epsilon subdivisions,2WIN4@28221|Deltaproteobacteria,2YU7Y@29|Myxococcales	28221|Deltaproteobacteria	H	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate	hutU	-	4.2.1.49	ko:K01712	ko00340,ko01100,map00340,map01100	M00045	R02914	RC00804	ko00000,ko00001,ko00002,ko01000	-	-	-	Urocanase,Urocanase_C,Urocanase_N
HKD2_k127_1580700_0	448385.sce6592	3.729e-236	790.0	COG0457@1|root,COG0457@2|Bacteria,1PC8F@1224|Proteobacteria,438AR@68525|delta/epsilon subdivisions,2X3K3@28221|Deltaproteobacteria,2YWDI@29|Myxococcales	28221|Deltaproteobacteria	S	Tetratricopeptide repeats	-	-	-	-	-	-	-	-	-	-	-	-	TPR_19
HKD2_k127_1580700_1	1192034.CAP_7377	3.512e-31	128.0	COG4796@1|root,COG4796@2|Bacteria,1QX5J@1224|Proteobacteria,4310N@68525|delta/epsilon subdivisions,2WWI7@28221|Deltaproteobacteria,2YVID@29|Myxococcales	28221|Deltaproteobacteria	U	Type ii and iii secretion system protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1584450_1	1242864.D187_005375	4.515e-134	442.0	COG1086@1|root,COG2148@1|root,COG1086@2|Bacteria,COG2148@2|Bacteria,1MV6W@1224|Proteobacteria,42MZY@68525|delta/epsilon subdivisions,2WJWT@28221|Deltaproteobacteria,2YXQ1@29|Myxococcales	28221|Deltaproteobacteria	M	Bacterial sugar transferase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_transf,CoA_binding_3
HKD2_k127_1584450_11	1111069.TCCBUS3UF1_7280	1.885e-15	81.0	COG0745@1|root,COG0745@2|Bacteria,1WK4G@1297|Deinococcus-Thermus	1111069.TCCBUS3UF1_7280|-	T	response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1584450_14	570268.ANBB01000015_gene3707	2.379e-11	74.0	COG0110@1|root,COG0110@2|Bacteria,2GNUB@201174|Actinobacteria,4ENX8@85012|Streptosporangiales	201174|Actinobacteria	S	Maltose acetyltransferase	maa	-	2.3.1.79	ko:K00661	-	-	-	-	ko00000,ko01000	-	-	-	Hexapep,Hexapep_2,Mac
HKD2_k127_1584450_0	156889.Mmc1_0150	9.766e-142	478.0	COG3882@1|root,COG3882@2|Bacteria,1PNPC@1224|Proteobacteria,2TUY2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	HAD-superfamily phosphatase subfamily IIIC	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1584450_8	1183438.GKIL_2397	1.521e-20	108.0	COG0110@1|root,COG0110@2|Bacteria,1G9TY@1117|Cyanobacteria	1117|Cyanobacteria	T	PFAM Bacterial transferase hexapeptide (three repeats)	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep,Hexapep_2
HKD2_k127_1584450_5	404589.Anae109_3040	6.379e-70	264.0	COG1922@1|root,COG1922@2|Bacteria,1N1HD@1224|Proteobacteria,42TWK@68525|delta/epsilon subdivisions,2WQSK@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Belongs to the glycosyltransferase 26 family	-	-	2.4.1.187	ko:K05946	ko05111,map05111	-	-	-	ko00000,ko00001,ko01000,ko01003	-	GT26	-	Glyco_tran_WecB
HKD2_k127_1584450_4	1242864.D187_005365	8.067e-99	352.0	COG1045@1|root,COG1216@1|root,COG1045@2|Bacteria,COG1216@2|Bacteria,1RJPX@1224|Proteobacteria,43AJP@68525|delta/epsilon subdivisions,2WSH6@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HKD2_k127_1584450_10	1144275.COCOR_08054	9.579e-16	88.0	28S7A@1|root,2ZEIR@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1584450_3	483219.LILAB_09195	1.369e-115	397.0	COG1215@1|root,COG1215@2|Bacteria,1PU38@1224|Proteobacteria,42UXK@68525|delta/epsilon subdivisions,2WQNC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Glycosyl transferase family group 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3
HKD2_k127_1584450_6	1144275.COCOR_08037	1.78e-62	233.0	COG3206@1|root,COG3206@2|Bacteria	2|Bacteria	M	extracellular polysaccharide biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1584450_9	485913.Krac_2406	1.022e-19	94.0	COG0736@1|root,COG0736@2|Bacteria	2|Bacteria	I	holo-[acyl-carrier-protein] synthase activity	acpS	-	2.7.8.7	ko:K00997	ko00770,map00770	-	R01625	RC00002	ko00000,ko00001,ko01000	-	-	-	ACPS
HKD2_k127_1584450_7	1380390.JIAT01000009_gene1689	7.517e-27	114.0	COG0236@1|root,COG0236@2|Bacteria,2GSZF@201174|Actinobacteria,4CTIJ@84995|Rubrobacteria	84995|Rubrobacteria	IQ	Phosphopantetheine attachment site	-	-	-	-	-	-	-	-	-	-	-	-	PP-binding
HKD2_k127_1584450_2	1538295.JY96_11985	4.546e-116	390.0	COG1960@1|root,COG1960@2|Bacteria,1QV2D@1224|Proteobacteria,2VPKP@28216|Betaproteobacteria	28216|Betaproteobacteria	I	acyl-CoA dehydrogenase	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_2,Acyl-CoA_dh_N
HKD2_k127_1584450_13	1538295.JY96_20820	1.896e-11	66.0	COG0172@1|root,COG0172@2|Bacteria,1PHJG@1224|Proteobacteria,2VPIG@28216|Betaproteobacteria	28216|Betaproteobacteria	J	seryl-tRNA synthetase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1585825_3	234267.Acid_6164	1.288e-08	66.0	COG0823@1|root,COG2374@1|root,COG3170@1|root,COG3291@1|root,COG3391@1|root,COG3867@1|root,COG4257@1|root,COG4625@1|root,COG0823@2|Bacteria,COG2374@2|Bacteria,COG3170@2|Bacteria,COG3291@2|Bacteria,COG3391@2|Bacteria,COG3867@2|Bacteria,COG4257@2|Bacteria,COG4625@2|Bacteria,3Y354@57723|Acidobacteria	2|Bacteria	M	PKD domain containing protein	-	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	3.2.1.4	ko:K01179,ko:K07004,ko:K13277,ko:K20276,ko:K21449	ko00500,ko01100,ko02024,map00500,map01100,map02024	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000,ko01002,ko02000,ko03110	1.B.40.2	GH5,GH9	-	Big_3_2,Exo_endo_phos,He_PIG,LTD
HKD2_k127_1585825_1	1313421.JHBV01000014_gene3886	9.852e-63	233.0	COG1680@1|root,COG1680@2|Bacteria,4NEVS@976|Bacteroidetes,1IRZ6@117747|Sphingobacteriia	976|Bacteroidetes	V	COG1680 Beta-lactamase class C and other penicillin binding	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
HKD2_k127_1585825_0	1242864.D187_007961	1.216e-65	237.0	COG2203@1|root,COG4191@1|root,COG2203@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42NFY@68525|delta/epsilon subdivisions,2X9PE@28221|Deltaproteobacteria,2YYYM@29|Myxococcales	28221|Deltaproteobacteria	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA
HKD2_k127_1585825_2	448385.sce4795	6.634e-32	134.0	COG2265@1|root,COG2265@2|Bacteria	2|Bacteria	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_12,Methyltransf_25,Methyltransf_31
HKD2_k127_1585825_4	1254432.SCE1572_20425	4.545e-05	51.0	COG0823@1|root,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,PA14,PD40,PKD
HKD2_k127_158960_2	272134.KB731324_gene2648	3.615e-36	150.0	COG0300@1|root,COG0300@2|Bacteria,1G2GZ@1117|Cyanobacteria,1H7D2@1150|Oscillatoriales	1117|Cyanobacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HKD2_k127_158960_1	1545915.JROG01000004_gene2307	2.756e-122	403.0	COG1960@1|root,COG1960@2|Bacteria,1MX17@1224|Proteobacteria,2TTRE@28211|Alphaproteobacteria,2K20J@204457|Sphingomonadales	204457|Sphingomonadales	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	ko:K18244	-	-	-	-	ko00000,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HKD2_k127_158960_0	391625.PPSIR1_40340	3.652e-131	454.0	COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,42N2G@68525|delta/epsilon subdivisions,2WIXB@28221|Deltaproteobacteria,2YTZ2@29|Myxococcales	28221|Deltaproteobacteria	I	COG1022 Long-chain acyl-CoA synthetases (AMP-forming)	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
HKD2_k127_158960_3	1313421.JHBV01000015_gene5763	2.331e-31	137.0	COG1409@1|root,COG1409@2|Bacteria	2|Bacteria	S	acid phosphatase activity	-	-	3.1.4.53	ko:K03651	ko00230,ko02025,map00230,map02025	-	R00191	RC00296	ko00000,ko00001,ko01000	-	-	-	Big_4,F5_F8_type_C,Laminin_G_3,Metallophos
HKD2_k127_158960_4	1254432.SCE1572_07890	5.793e-20	91.0	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,42MMK@68525|delta/epsilon subdivisions,2WJC1@28221|Deltaproteobacteria,2YUAB@29|Myxococcales	28221|Deltaproteobacteria	S	ABC transporter	yjjK	-	3.6.3.25	ko:K06020	-	-	-	-	ko00000,ko01000	-	-	-	ABC_tran,ABC_tran_Xtn
HKD2_k127_1596654_1	661478.OP10G_4575	9.584e-86	293.0	COG0531@1|root,COG0531@2|Bacteria	2|Bacteria	E	amino acid	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
HKD2_k127_1596654_3	1254432.SCE1572_14920	8.215e-35	154.0	COG0457@1|root,COG0457@2|Bacteria	1254432.SCE1572_14920|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1596654_0	1192034.CAP_6942	9.758e-99	340.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,42MVV@68525|delta/epsilon subdivisions,2X4JB@28221|Deltaproteobacteria,2YZ4I@29|Myxococcales	28221|Deltaproteobacteria	KLT	Family membership	-	-	2.7.11.1	ko:K08884	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HKD2_k127_1596654_2	378806.STAUR_3337	6.869e-71	243.0	COG3104@1|root,COG3104@2|Bacteria,1MW6W@1224|Proteobacteria,42NNY@68525|delta/epsilon subdivisions,2WKK6@28221|Deltaproteobacteria,2YUFS@29|Myxococcales	28221|Deltaproteobacteria	P	POT family	-	-	-	ko:K03305	-	-	-	-	ko00000	2.A.17	-	-	PTR2
HKD2_k127_1600686_14	1254432.SCE1572_00205	1.659e-43	171.0	COG0457@1|root,COG0457@2|Bacteria	1254432.SCE1572_00205|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1600686_8	1192034.CAP_1769	2.984e-53	203.0	COG0515@1|root,COG0515@2|Bacteria	1192034.CAP_1769|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1600686_20	1463845.JOIG01000004_gene4053	5.027e-09	61.0	COG0766@1|root,COG1396@1|root,COG0766@2|Bacteria,COG1396@2|Bacteria,2GJPW@201174|Actinobacteria	201174|Actinobacteria	M	Belongs to the EPSP synthase family. MurA subfamily	murA	-	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase,HTH_3
HKD2_k127_1600686_13	448385.sce2007	8.664e-44	170.0	COG1075@1|root,COG1075@2|Bacteria	2|Bacteria	KLT	acetyltransferases and hydrolases with the alpha beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6,PGAP1
HKD2_k127_1600686_15	215803.DB30_6696	1.081e-36	143.0	COG0824@1|root,COG0824@2|Bacteria,1RI3X@1224|Proteobacteria,42SW5@68525|delta/epsilon subdivisions,2WW97@28221|Deltaproteobacteria,2Z1TM@29|Myxococcales	28221|Deltaproteobacteria	S	Acyl-ACP thioesterase	-	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	Acyl-ACP_TE
HKD2_k127_1600686_4	1192034.CAP_0938	1.329e-116	399.0	COG1287@1|root,COG1287@2|Bacteria	2|Bacteria	S	oligosaccharyl transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1600686_10	448385.sce2005	1.267e-50	188.0	COG0457@1|root,COG0457@2|Bacteria	448385.sce2005|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1600686_1	290397.Adeh_3707	2.567e-156	511.0	COG0626@1|root,COG0626@2|Bacteria,1MU57@1224|Proteobacteria,42M67@68525|delta/epsilon subdivisions,2WJQX@28221|Deltaproteobacteria,2YTX6@29|Myxococcales	28221|Deltaproteobacteria	E	Cys Met metabolism	metC	-	2.5.1.48,4.4.1.1	ko:K01739,ko:K01758	ko00260,ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00260,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017,M00338	R00782,R00999,R01001,R01288,R02408,R02508,R03217,R03260,R04770,R04930,R04944,R04945,R04946,R09366	RC00020,RC00056,RC00069,RC00348,RC00382,RC00420,RC00710,RC01209,RC01210,RC01245,RC02303,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Cys_Met_Meta_PP
HKD2_k127_1600686_17	1121385.AQXW01000004_gene2005	6.16e-14	85.0	COG0515@1|root,COG0515@2|Bacteria,2GNXG@201174|Actinobacteria	201174|Actinobacteria	KLT	serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
HKD2_k127_1600686_9	1449346.JQMO01000003_gene6799	1.717e-51	195.0	COG1502@1|root,COG1502@2|Bacteria,2HA2M@201174|Actinobacteria,2M1DU@2063|Kitasatospora	201174|Actinobacteria	I	PLD-like domain	-	-	-	-	-	-	-	-	-	-	-	-	He_PIG,PLDc_2
HKD2_k127_1600686_16	448385.sce4145	3.301e-14	83.0	COG0400@1|root,COG0400@2|Bacteria	2|Bacteria	S	palmitoyl-(protein) hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_2
HKD2_k127_1600686_7	1254432.SCE1572_10990	6.587e-97	330.0	COG1716@1|root,COG2199@1|root,COG1716@2|Bacteria,COG3706@2|Bacteria,1MZV7@1224|Proteobacteria,4302C@68525|delta/epsilon subdivisions,2WVBW@28221|Deltaproteobacteria,2YUSZ@29|Myxococcales	28221|Deltaproteobacteria	T	GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	FHA,GGDEF,Yop-YscD_cpl
HKD2_k127_1600686_2	452637.Oter_3624	1.157e-149	488.0	COG2723@1|root,COG2723@2|Bacteria	2|Bacteria	G	beta-glucosidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_1,Glycos_transf_1
HKD2_k127_1600686_0	452637.Oter_3623	3.636e-178	582.0	COG2723@1|root,COG2723@2|Bacteria,46WQV@74201|Verrucomicrobia	74201|Verrucomicrobia	G	Glycosyl hydrolase family 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_1
HKD2_k127_1600686_3	211165.AJLN01000062_gene3907	2.269e-127	415.0	COG3940@1|root,COG3940@2|Bacteria,1G4B4@1117|Cyanobacteria	1117|Cyanobacteria	G	Belongs to the glycosyl hydrolase 43 family	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_43
HKD2_k127_1600686_21	57918.XP_004296571.1	2.541e-06	59.0	28KQ9@1|root,2QRKW@2759|Eukaryota,37JAP@33090|Viridiplantae,3GFQS@35493|Streptophyta,4JH04@91835|fabids	35493|Streptophyta	S	Chlorophyllase-2	-	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006787,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009507,GO:0009536,GO:0009987,GO:0015994,GO:0015996,GO:0016787,GO:0016788,GO:0019439,GO:0033013,GO:0033015,GO:0034641,GO:0042440,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044248,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046149,GO:0046483,GO:0046700,GO:0047746,GO:0051186,GO:0051187,GO:0052689,GO:0071704,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575	3.1.1.14	ko:K08099	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R05618,R09068	RC00020,RC00041	ko00000,ko00001,ko01000	-	-	-	Chlorophyllase,Chlorophyllase2
HKD2_k127_1600686_22	487316.BBNM01000005_gene125	0.000176	44.0	2A2R8@1|root,30R45@2|Bacteria,1QBY9@1224|Proteobacteria,1T7JH@1236|Gammaproteobacteria,3NSE4@468|Moraxellaceae	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1600686_5	448385.sce6159	2.23e-105	352.0	COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,42NQP@68525|delta/epsilon subdivisions,2WIQD@28221|Deltaproteobacteria,2YUVF@29|Myxococcales	28221|Deltaproteobacteria	BQ	Histone deacetylase domain	-	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
HKD2_k127_1600686_12	1192034.CAP_0165	1.845e-44	174.0	COG1413@1|root,COG1413@2|Bacteria,1PC2V@1224|Proteobacteria,4387S@68525|delta/epsilon subdivisions,2X3HJ@28221|Deltaproteobacteria,2YW4Z@29|Myxococcales	28221|Deltaproteobacteria	C	lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2
HKD2_k127_1600686_11	1242864.D187_009428	1.549e-48	183.0	2EQTB@1|root,33ID2@2|Bacteria,1P3AG@1224|Proteobacteria,4387H@68525|delta/epsilon subdivisions,2X3HD@28221|Deltaproteobacteria,2YW3P@29|Myxococcales	28221|Deltaproteobacteria	S	Lytic polysaccharide mono-oxygenase, cellulose-degrading	-	-	-	-	-	-	-	-	-	-	-	-	LPMO_10
HKD2_k127_1616355_1	1192034.CAP_5439	7.411e-06	49.0	COG2203@1|root,COG2204@1|root,COG2206@1|root,COG2203@2|Bacteria,COG2204@2|Bacteria,COG2206@2|Bacteria,1RAQS@1224|Proteobacteria,42MEJ@68525|delta/epsilon subdivisions,2X71A@28221|Deltaproteobacteria,2YUZY@29|Myxococcales	28221|Deltaproteobacteria	T	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,GAF_3,HD,Response_reg
HKD2_k127_1616355_0	448385.sce7299	1.12e-32	134.0	COG1266@1|root,COG1266@2|Bacteria,1RI59@1224|Proteobacteria,433F0@68525|delta/epsilon subdivisions,2WYHI@28221|Deltaproteobacteria,2Z276@29|Myxococcales	28221|Deltaproteobacteria	S	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
HKD2_k127_1621604_0	72019.SARC_09392T0	6.296e-92	308.0	COG1028@1|root,KOG1208@2759|Eukaryota,38CZD@33154|Opisthokonta	2759|Eukaryota	Q	oxidoreductase activity	-	-	1.1.1.300	ko:K11153	ko00830,ko01100,map00830,map01100	-	R08379,R08383	RC00649	ko00000,ko00001,ko01000	-	-	-	adh_short
HKD2_k127_1621604_3	1254432.SCE1572_11940	8.441e-30	137.0	2DAKI@1|root,32TVP@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1621604_1	697303.Thewi_2635	9.883e-37	147.0	COG0695@1|root,COG3118@1|root,COG0695@2|Bacteria,COG3118@2|Bacteria,1VI6J@1239|Firmicutes,24QNT@186801|Clostridia,42G2F@68295|Thermoanaerobacterales	186801|Clostridia	O	PFAM glutaredoxin	-	-	-	-	-	-	-	-	-	-	-	-	Glutaredoxin
HKD2_k127_1621604_4	340099.Teth39_0115	3.598e-18	89.0	COG0234@1|root,COG0234@2|Bacteria,1VY33@1239|Firmicutes,25281@186801|Clostridia,42IHH@68295|Thermoanaerobacterales	186801|Clostridia	O	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter	-	-	-	ko:K04078	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Cpn10
HKD2_k127_1621604_2	247634.GPB2148_3568	2.152e-34	147.0	COG0702@1|root,COG0702@2|Bacteria,1RDKF@1224|Proteobacteria,1S0A1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	GM	NAD(P)H-binding	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_10
HKD2_k127_1621604_7	112098.XP_008620210.1	3.098e-09	70.0	COG0666@1|root,KOG4177@2759|Eukaryota	2759|Eukaryota	I	spectrin binding	-	-	-	-	-	-	-	-	-	-	-	-	Ank,Ank_2,Ank_3,Ank_4,Pkinase,Pkinase_Tyr
HKD2_k127_1621604_9	338963.Pcar_1532	0.0009916	48.0	2ART5@1|root,336GI@2|Bacteria,1R39N@1224|Proteobacteria,4322V@68525|delta/epsilon subdivisions,2WWQQ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1631062_5	1304885.AUEY01000015_gene2961	2.766e-05	52.0	COG0725@1|root,COG0725@2|Bacteria,1MVNA@1224|Proteobacteria,42MZE@68525|delta/epsilon subdivisions,2WKJB@28221|Deltaproteobacteria,2MJDV@213118|Desulfobacterales	28221|Deltaproteobacteria	P	TIGRFAM molybdenum ABC transporter, periplasmic molybdate-binding protein	modA	-	-	ko:K02020	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.8	-	iAF987.Gmet_0512	SBP_bac_11
HKD2_k127_1631062_3	448385.sce2941	1.047e-54	195.0	COG0314@1|root,COG0314@2|Bacteria,1RGUX@1224|Proteobacteria,437BZ@68525|delta/epsilon subdivisions,2WQNB@28221|Deltaproteobacteria,2YVJC@29|Myxococcales	28221|Deltaproteobacteria	H	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin	moaD	-	2.8.1.12	ko:K03635,ko:K21142	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09395	RC02507	ko00000,ko00001,ko01000	-	-	-	MoaE,ThiS
HKD2_k127_1631062_0	1242864.D187_004965	3.918e-87	314.0	COG0003@1|root,COG0003@2|Bacteria,1PMWP@1224|Proteobacteria,42RUR@68525|delta/epsilon subdivisions,2WNEE@28221|Deltaproteobacteria,2YUU4@29|Myxococcales	28221|Deltaproteobacteria	D	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	ArsA_ATPase
HKD2_k127_1631062_2	1297742.A176_07656	3.634e-55	215.0	COG0003@1|root,COG0003@2|Bacteria,1NA7C@1224|Proteobacteria,42V2J@68525|delta/epsilon subdivisions,2WS25@28221|Deltaproteobacteria,2YUZS@29|Myxococcales	28221|Deltaproteobacteria	P	Anion-transporting ATPase	-	-	3.6.3.16	ko:K01551	-	-	-	-	ko00000,ko01000,ko02000	3.A.19.1,3.A.21.1,3.A.4.1	-	-	ArsA_ATPase
HKD2_k127_1631062_4	1255043.TVNIR_3592	1.716e-37	155.0	COG0315@1|root,COG0315@2|Bacteria,1RCYZ@1224|Proteobacteria,1S3ST@1236|Gammaproteobacteria,1WY7V@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)	moaC	-	4.6.1.17	ko:K03637	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R11372	RC03425	ko00000,ko00001,ko01000	-	-	-	MoaC
HKD2_k127_1631062_1	448385.sce2402	5.466e-81	280.0	COG0303@1|root,COG0303@2|Bacteria,1MVD5@1224|Proteobacteria,42M5U@68525|delta/epsilon subdivisions,2X5HK@28221|Deltaproteobacteria,2Z35S@29|Myxococcales	28221|Deltaproteobacteria	H	MoeA C-terminal region (domain IV)	moeA	-	2.10.1.1	ko:K03750	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N
HKD2_k127_1634957_0	215803.DB30_3143	2.843e-154	497.0	COG0038@1|root,COG0517@1|root,COG0038@2|Bacteria,COG0517@2|Bacteria,1MV4K@1224|Proteobacteria,42PJQ@68525|delta/epsilon subdivisions,2WKR4@28221|Deltaproteobacteria,2YTY6@29|Myxococcales	28221|Deltaproteobacteria	P	Voltage gated chloride channel	-	-	-	ko:K03281	-	-	-	-	ko00000	2.A.49	-	-	CBS,Voltage_CLC
HKD2_k127_1634957_3	1123393.KB891326_gene103	3.915e-76	269.0	COG3213@1|root,COG3213@2|Bacteria,1MUJK@1224|Proteobacteria,2VJ75@28216|Betaproteobacteria,1KRS1@119069|Hydrogenophilales	119069|Hydrogenophilales	P	NnrS protein	-	-	-	ko:K07234	-	-	-	-	ko00000	-	-	-	NnrS
HKD2_k127_1634957_5	1304883.KI912532_gene2568	9.88e-35	135.0	COG4309@1|root,COG4309@2|Bacteria,1N4MS@1224|Proteobacteria,2VU7H@28216|Betaproteobacteria,2KXFV@206389|Rhodocyclales	206389|Rhodocyclales	S	Uncharacterized conserved protein (DUF2249)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2249
HKD2_k127_1634957_2	667014.Thein_1262	1.347e-82	290.0	COG1236@1|root,COG1236@2|Bacteria,2GH5P@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	J	Beta-Casp domain	-	-	-	ko:K07576	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B,RMMBL
HKD2_k127_1634957_8	926550.CLDAP_00150	1.111e-05	56.0	COG0664@1|root,COG0664@2|Bacteria,2G902@200795|Chloroflexi	200795|Chloroflexi	C	4fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_6,Fer4_7,cNMP_binding
HKD2_k127_1634957_4	448385.sce4529	2.505e-66	237.0	COG1633@1|root,COG1633@2|Bacteria	2|Bacteria	S	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)	-	-	1.16.3.1	ko:K03594,ko:K07052	ko00860,map00860	-	R00078	RC02758	ko00000,ko00001,ko01000	-	-	-	-
HKD2_k127_1634957_6	208444.JNYY01000001_gene5311	1.658e-27	116.0	2CRSQ@1|root,32SPK@2|Bacteria,2IQ50@201174|Actinobacteria,4E6R0@85010|Pseudonocardiales	201174|Actinobacteria	S	DoxX-like family	-	-	-	-	-	-	-	-	-	-	-	-	DoxX_2
HKD2_k127_1634957_1	448385.sce7230	6.753e-132	446.0	COG0539@1|root,COG0539@2|Bacteria,1N2EJ@1224|Proteobacteria,42NXS@68525|delta/epsilon subdivisions,2WJ0A@28221|Deltaproteobacteria,2YV19@29|Myxococcales	28221|Deltaproteobacteria	J	Ribosomal protein S1-like RNA-binding domain	-	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
HKD2_k127_1636004_2	448385.sce2898	5.806e-81	282.0	COG0109@1|root,COG0109@2|Bacteria,1MW3S@1224|Proteobacteria,42UME@68525|delta/epsilon subdivisions,2WR3J@28221|Deltaproteobacteria,2YUW1@29|Myxococcales	28221|Deltaproteobacteria	O	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group	ctaB	-	2.5.1.141	ko:K02257	ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714	M00154	R07411	RC01786	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029	-	-	-	UbiA
HKD2_k127_1636004_0	1254432.SCE1572_12305	1.016e-180	616.0	COG0457@1|root,COG0515@1|root,COG3899@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG3899@2|Bacteria,1QA6R@1224|Proteobacteria,438FC@68525|delta/epsilon subdivisions,2X3QC@28221|Deltaproteobacteria,2YWU9@29|Myxococcales	28221|Deltaproteobacteria	KLT	Family membership	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,Pkinase
HKD2_k127_1636004_4	1175306.GWL_31020	6.459e-23	113.0	COG2202@1|root,COG4191@1|root,COG2202@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2VJGE@28216|Betaproteobacteria,476K9@75682|Oxalobacteraceae	28216|Betaproteobacteria	T	PAS fold	-	-	2.7.13.3	ko:K02482	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	GAF_2,HATPase_c,HisKA,MHYT,PAS,PAS_3,PAS_9
HKD2_k127_1636004_1	457570.Nther_2188	1.478e-81	300.0	COG4805@1|root,COG4805@2|Bacteria	2|Bacteria	S	Bacterial protein of unknown function (DUF885)	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
HKD2_k127_1636004_6	448385.sce1850	1.471e-05	57.0	COG0457@1|root,COG0457@2|Bacteria	448385.sce1850|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1636004_5	485913.Krac_4700	1.597e-15	89.0	2DRZ7@1|root,33DSV@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1636004_3	448385.sce5470	1.234e-56	214.0	COG0515@1|root,COG0515@2|Bacteria	448385.sce5470|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1641420_3	935557.ATYB01000009_gene798	5.093e-16	84.0	COG2823@1|root,COG2823@2|Bacteria,1N1R4@1224|Proteobacteria,2UDII@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	periplasmic or secreted lipoprotein	-	-	-	-	-	-	-	-	-	-	-	-	BON
HKD2_k127_1641420_2	448385.sce0283	1.336e-50	192.0	COG4105@1|root,COG4105@2|Bacteria	2|Bacteria	S	cell envelope organization	bamD	-	-	ko:K05807,ko:K08309	-	-	-	-	ko00000,ko01000,ko01011,ko02000	1.B.33.1	GH23	-	YfiO
HKD2_k127_1641420_1	448385.sce4512	9.226e-89	312.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,42MVV@68525|delta/epsilon subdivisions,2X4JB@28221|Deltaproteobacteria,2YZ4I@29|Myxococcales	28221|Deltaproteobacteria	KLT	Family membership	-	-	2.7.11.1	ko:K08884	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HKD2_k127_1641420_0	448385.sce1668	5.208e-129	420.0	COG0206@1|root,COG0206@2|Bacteria,1MV2X@1224|Proteobacteria,42MHK@68525|delta/epsilon subdivisions,2WJAZ@28221|Deltaproteobacteria,2YTTW@29|Myxococcales	28221|Deltaproteobacteria	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
HKD2_k127_1643608_1	1192034.CAP_7919	6.695e-83	293.0	COG3419@1|root,COG3419@2|Bacteria,1NUAV@1224|Proteobacteria,42NJ7@68525|delta/epsilon subdivisions,2WJYB@28221|Deltaproteobacteria,2YW3S@29|Myxococcales	28221|Deltaproteobacteria	NU	Tfp pilus assembly protein tip-associated adhesin	-	-	-	ko:K02674	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	Neisseria_PilC
HKD2_k127_1643608_5	1254432.SCE1572_12335	1.756e-27	129.0	COG4966@1|root,COG4966@2|Bacteria	2|Bacteria	NU	pilus assembly protein PilW	-	-	-	ko:K02672	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	N_methyl
HKD2_k127_1643608_6	1254432.SCE1572_12340	2.901e-15	89.0	COG4967@1|root,COG4967@2|Bacteria	2|Bacteria	NU	type IV pilus modification protein PilV	pilV-1	-	-	ko:K02671,ko:K02681	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	N_methyl
HKD2_k127_1643608_8	697281.Mahau_1123	0.000629	51.0	COG2165@1|root,COG2165@2|Bacteria,1VK8F@1239|Firmicutes,24UDT@186801|Clostridia,42JGX@68295|Thermoanaerobacterales	186801|Clostridia	U	Pfam:N_methyl_2	-	-	-	ko:K02456,ko:K02650	ko02020,ko03070,ko05111,map02020,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15,3.A.15.2	-	-	N_methyl
HKD2_k127_1643608_0	1192034.CAP_2179	2.203e-87	301.0	COG0164@1|root,COG0164@2|Bacteria	2|Bacteria	L	RNA-DNA hybrid ribonuclease activity	-	-	3.1.26.4	ko:K03470	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_HII
HKD2_k127_1643608_3	1192034.CAP_6945	1.066e-59	209.0	COG1734@1|root,COG1734@2|Bacteria,1N8RB@1224|Proteobacteria,42W5H@68525|delta/epsilon subdivisions,2WSAD@28221|Deltaproteobacteria,2YVJ6@29|Myxococcales	28221|Deltaproteobacteria	T	Prokaryotic dksA/traR C4-type zinc finger	dksA	-	-	ko:K06204	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000,ko03009,ko03021	-	-	-	zf-dskA_traR
HKD2_k127_1643608_4	1192034.CAP_6944	1.542e-47	172.0	COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,42M4I@68525|delta/epsilon subdivisions,2WJHM@28221|Deltaproteobacteria,2YY9M@29|Myxococcales	28221|Deltaproteobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
HKD2_k127_1648808_1	1380391.JIAS01000013_gene3695	1.216e-37	149.0	COG1309@1|root,COG1309@2|Bacteria,1PJ6M@1224|Proteobacteria,2V9MS@28211|Alphaproteobacteria,2JYAP@204441|Rhodospirillales	204441|Rhodospirillales	K	Tetracyclin repressor, C-terminal all-alpha domain	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C,TetR_N
HKD2_k127_1648808_0	448385.sce0013	3.636e-108	364.0	COG1807@1|root,COG1807@2|Bacteria,1NMIZ@1224|Proteobacteria,42RXF@68525|delta/epsilon subdivisions,2WNF1@28221|Deltaproteobacteria,2YV5A@29|Myxococcales	28221|Deltaproteobacteria	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	arnT	-	-	-	-	-	-	-	-	-	-	-	PMT,PMT_2
HKD2_k127_1649378_0	448385.sce3926	3.48e-166	534.0	COG1048@1|root,COG1048@2|Bacteria,1MU9T@1224|Proteobacteria,42N5M@68525|delta/epsilon subdivisions,2WIIV@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	aconitate hydratase	aco	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2763	Aconitase,Aconitase_C
HKD2_k127_1649378_1	391625.PPSIR1_07445	1.207e-46	179.0	COG3137@1|root,COG3137@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K07283	-	-	-	-	ko00000	-	-	-	DUF481
HKD2_k127_166119_3	1192034.CAP_2819	2.171e-43	168.0	COG1946@1|root,COG1946@2|Bacteria,1NAQM@1224|Proteobacteria,42RR6@68525|delta/epsilon subdivisions,2WNXU@28221|Deltaproteobacteria,2YVQF@29|Myxococcales	28221|Deltaproteobacteria	I	Thioesterase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT_3
HKD2_k127_166119_6	34740.HMEL008888-PA	5.107e-09	66.0	COG5239@1|root,KOG0620@2759|Eukaryota,38DYK@33154|Opisthokonta,3B9VG@33208|Metazoa,3CSNT@33213|Bilateria,41W79@6656|Arthropoda,3SGWX@50557|Insecta,442SK@7088|Lepidoptera	33208|Metazoa	K	Endonuclease/Exonuclease/phosphatase family	CNOT6L	GO:0000003,GO:0000075,GO:0000077,GO:0000175,GO:0000278,GO:0000288,GO:0000289,GO:0000291,GO:0000956,GO:0003006,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004535,GO:0004540,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005829,GO:0006139,GO:0006401,GO:0006402,GO:0006417,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006977,GO:0007049,GO:0007093,GO:0007154,GO:0007165,GO:0007276,GO:0007281,GO:0007292,GO:0007346,GO:0008150,GO:0008152,GO:0008284,GO:0008356,GO:0008408,GO:0009056,GO:0009057,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009894,GO:0009896,GO:0009987,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010564,GO:0010603,GO:0010604,GO:0010605,GO:0010606,GO:0010608,GO:0010629,GO:0010638,GO:0010948,GO:0016070,GO:0016071,GO:0016441,GO:0016458,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0017145,GO:0017148,GO:0019219,GO:0019222,GO:0019439,GO:0019953,GO:0022402,GO:0022412,GO:0022414,GO:0023052,GO:0030014,GO:0030154,GO:0030330,GO:0031047,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0031329,GO:0031331,GO:0031334,GO:0031570,GO:0031571,GO:0032268,GO:0032269,GO:0032501,GO:0032502,GO:0032504,GO:0032991,GO:0033043,GO:0033554,GO:0034248,GO:0034249,GO:0034641,GO:0034655,GO:0035194,GO:0035195,GO:0035556,GO:0040029,GO:0042078,GO:0042127,GO:0042770,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043254,GO:0043487,GO:0043488,GO:0043928,GO:0044087,GO:0044089,GO:0044093,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0044703,GO:0044773,GO:0044774,GO:0044783,GO:0044819,GO:0045786,GO:0045787,GO:0045930,GO:0045935,GO:0046483,GO:0046700,GO:0048132,GO:0048468,GO:0048477,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048609,GO:0048856,GO:0048869,GO:0050779,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051130,GO:0051171,GO:0051172,GO:0051173,GO:0051246,GO:0051248,GO:0051252,GO:0051254,GO:0051301,GO:0051704,GO:0051716,GO:0051726,GO:0060255,GO:0061013,GO:0061014,GO:0061157,GO:0065007,GO:0065008,GO:0065009,GO:0070966,GO:0071156,GO:0071158,GO:0071704,GO:0072331,GO:0072395,GO:0072401,GO:0072413,GO:0072422,GO:0072431,GO:0080090,GO:0090068,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0098722,GO:0098728,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901987,GO:1901988,GO:1901990,GO:1901991,GO:1902115,GO:1902117,GO:1902400,GO:1902402,GO:1902403,GO:1902680,GO:1902806,GO:1902807,GO:1903047,GO:1903311,GO:1903313,GO:1903506,GO:1903508,GO:2000045,GO:2000112,GO:2000113,GO:2000134,GO:2000325,GO:2000327,GO:2001141	3.1.13.4	ko:K12603,ko:K20363	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019,ko04131	-	-	-	Exo_endo_phos,LRR_8
HKD2_k127_166119_0	1278073.MYSTI_02882	2.395e-90	318.0	COG2129@1|root,COG2129@2|Bacteria,1R3TH@1224|Proteobacteria	1224|Proteobacteria	S	phosphoesterases, related to the Icc protein	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos,Metallophos_2
HKD2_k127_166119_5	1121439.dsat_1265	1.395e-19	100.0	COG0476@1|root,COG0778@1|root,COG0476@2|Bacteria,COG0778@2|Bacteria,1QUMS@1224|Proteobacteria,42P3N@68525|delta/epsilon subdivisions,2WKH0@28221|Deltaproteobacteria,2M8Y7@213115|Desulfovibrionales	28221|Deltaproteobacteria	H	PFAM UBA THIF-type NAD FAD binding	-	-	-	-	-	-	-	-	-	-	-	-	ThiF
HKD2_k127_166119_2	1254432.SCE1572_11630	2.438e-62	230.0	arCOG10456@1|root,2ZA6T@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_166119_1	448385.sce1851	9.656e-85	312.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,42MVV@68525|delta/epsilon subdivisions,2X4JB@28221|Deltaproteobacteria,2YZ4I@29|Myxococcales	28221|Deltaproteobacteria	KLT	Family membership	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HKD2_k127_166119_4	448385.sce0283	2.886e-43	174.0	COG4105@1|root,COG4105@2|Bacteria	2|Bacteria	S	cell envelope organization	bamD	-	-	ko:K05807,ko:K08309	-	-	-	-	ko00000,ko01000,ko01011,ko02000	1.B.33.1	GH23	-	YfiO
HKD2_k127_1665761_1	1340493.JNIF01000003_gene4010	2.881e-34	144.0	COG1793@1|root,COG1793@2|Bacteria,3Y3AP@57723|Acidobacteria	57723|Acidobacteria	L	DNA ligase	-	-	6.5.1.1,6.5.1.6,6.5.1.7	ko:K10747	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00381,R00382,R10822,R10823	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,DNA_ligase_A_N
HKD2_k127_1665761_0	926560.KE387023_gene2649	7.869e-36	141.0	COG0782@1|root,COG0782@2|Bacteria	2|Bacteria	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus	greA	-	-	ko:K03624,ko:K04760	-	-	-	-	ko00000,ko03021	-	-	-	GreA_GreB,GreA_GreB_N
HKD2_k127_1665761_2	1380347.JNII01000011_gene977	2.562e-22	97.0	COG2267@1|root,COG2267@2|Bacteria,2I3AI@201174|Actinobacteria	201174|Actinobacteria	I	Alpha beta hydrolase	dhmA	-	3.8.1.5	ko:K01563	ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120	-	R05284,R05367,R05368,R05369,R05370,R07669,R07670	RC01317,RC01340,RC01341,RC02013	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1,Abhydrolase_6
HKD2_k127_1667167_4	448385.sce7248	4.128e-91	301.0	COG2018@1|root,COG2018@2|Bacteria,1RDN5@1224|Proteobacteria,42S13@68525|delta/epsilon subdivisions,2WNKB@28221|Deltaproteobacteria,2YV9Q@29|Myxococcales	28221|Deltaproteobacteria	S	Roadblock/LC7 domain	mglB	-	-	-	-	-	-	-	-	-	-	-	Robl_LC7
HKD2_k127_1667167_3	68260.JOAY01000008_gene793	1.548e-92	342.0	COG0624@1|root,COG0624@2|Bacteria,2GKKW@201174|Actinobacteria	201174|Actinobacteria	E	COG0624 Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase and related	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
HKD2_k127_1667167_1	1242864.D187_000389	1.577e-212	706.0	COG2911@1|root,COG2911@2|Bacteria,1N9X4@1224|Proteobacteria,4342H@68525|delta/epsilon subdivisions,2X4UP@28221|Deltaproteobacteria,2YZMQ@29|Myxococcales	28221|Deltaproteobacteria	S	Protein conserved in bacteria	-	-	-	ko:K09800	-	-	-	-	ko00000,ko02000	-	-	-	-
HKD2_k127_1667167_5	378806.STAUR_7734	6.523e-52	212.0	2F1YR@1|root,33UY5@2|Bacteria,1NVEZ@1224|Proteobacteria,438Q2@68525|delta/epsilon subdivisions,2X8VY@28221|Deltaproteobacteria,2YXGR@29|Myxococcales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF1318)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1318
HKD2_k127_1667167_0	1242864.D187_000387	0.0	1118.0	COG0823@1|root,COG0823@2|Bacteria,1NR88@1224|Proteobacteria,437C2@68525|delta/epsilon subdivisions,2X9JB@28221|Deltaproteobacteria,2YXU7@29|Myxococcales	28221|Deltaproteobacteria	U	WD40-like Beta Propeller Repeat	-	-	-	-	-	-	-	-	-	-	-	-	PD40
HKD2_k127_1667167_2	1192034.CAP_2901	2.549e-188	593.0	COG0156@1|root,COG0156@2|Bacteria,1MVVH@1224|Proteobacteria,42MM1@68525|delta/epsilon subdivisions,2WIU7@28221|Deltaproteobacteria,2YU40@29|Myxococcales	28221|Deltaproteobacteria	H	Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA	kbl	-	2.3.1.29	ko:K00639	ko00260,map00260	-	R00371	RC00004,RC00394	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
HKD2_k127_1671990_0	1192034.CAP_3456	1.138e-165	528.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,42Q1R@68525|delta/epsilon subdivisions,2WM4U@28221|Deltaproteobacteria,2YWW8@29|Myxococcales	28221|Deltaproteobacteria	C	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.3.8.7	ko:K00249,ko:K11731	ko00071,ko00280,ko00281,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00281,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754,R08089	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246,RC01893	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HKD2_k127_1671990_2	1379698.RBG1_1C00001G0799	5.248e-104	356.0	2C5G3@1|root,2Z8TT@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1671990_7	865937.Gilli_1015	3.862e-05	53.0	2EVPH@1|root,33P3G@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1671990_6	378806.STAUR_4189	2.747e-32	145.0	2DJS1@1|root,30745@2|Bacteria,1Q2J3@1224|Proteobacteria,4385Y@68525|delta/epsilon subdivisions,2X3FS@28221|Deltaproteobacteria,2YVWX@29|Myxococcales	28221|Deltaproteobacteria	S	Membrane bound O-acyl transferase family	-	-	-	-	-	-	-	-	-	-	-	-	MBOAT_2
HKD2_k127_1671990_4	500153.JOEK01000018_gene3007	2.639e-36	158.0	COG0122@1|root,COG0122@2|Bacteria,2GP69@201174|Actinobacteria	201174|Actinobacteria	L	3-methyladenine DNA glycosylase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1671990_5	1396141.BATP01000059_gene2620	4.411e-33	147.0	2EZQ1@1|root,33SV1@2|Bacteria,46U61@74201|Verrucomicrobia,2IVSN@203494|Verrucomicrobiae	203494|Verrucomicrobiae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1671990_1	378806.STAUR_5581	2.217e-141	468.0	COG1190@1|root,COG1190@2|Bacteria,1MX1V@1224|Proteobacteria,42M90@68525|delta/epsilon subdivisions,2WJ9G@28221|Deltaproteobacteria,2YUAA@29|Myxococcales	28221|Deltaproteobacteria	J	Belongs to the class-II aminoacyl-tRNA synthetase family	lysS	-	6.1.1.6	ko:K04567	ko00970,map00970	M00359,M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
HKD2_k127_1671990_3	1192034.CAP_7185	7.506e-41	167.0	COG4591@1|root,COG4591@2|Bacteria,1MVV7@1224|Proteobacteria,42MV0@68525|delta/epsilon subdivisions,2WITK@28221|Deltaproteobacteria,2YUSA@29|Myxococcales	28221|Deltaproteobacteria	M	ABC-type transport system involved in lipoprotein release permease component	lolC	-	-	ko:K09808	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.125	-	-	FtsX,MacB_PCD
HKD2_k127_1672263_4	290397.Adeh_3956	2.775e-07	53.0	2A9VF@1|root,30Z3B@2|Bacteria,1PKZS@1224|Proteobacteria,435JG@68525|delta/epsilon subdivisions,2WZXJ@28221|Deltaproteobacteria,2Z0YG@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1672263_3	861299.J421_1989	1.947e-09	70.0	COG2940@1|root,COG2940@2|Bacteria,1ZTHI@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Cysteine-rich motif following a subset of SET domains	-	-	-	ko:K07117	-	-	-	-	ko00000	-	-	-	SET
HKD2_k127_1672263_2	1192034.CAP_4347	2.127e-63	224.0	2A6Q2@1|root,30VI0@2|Bacteria,1QABI@1224|Proteobacteria,434YG@68525|delta/epsilon subdivisions,2X92X@28221|Deltaproteobacteria,2Z1MS@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1672263_0	483219.LILAB_28110	4.872e-253	808.0	COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,42M9W@68525|delta/epsilon subdivisions,2WJ29@28221|Deltaproteobacteria,2YUPG@29|Myxococcales	28221|Deltaproteobacteria	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	-	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
HKD2_k127_1672263_1	1192034.CAP_4336	1.922e-116	389.0	COG0457@1|root,COG0457@2|Bacteria,1QX7S@1224|Proteobacteria,43C0S@68525|delta/epsilon subdivisions,2X7BD@28221|Deltaproteobacteria,2YV1Y@29|Myxococcales	28221|Deltaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1674446_3	448385.sce3756	2.12e-90	304.0	2BKCR@1|root,32ETA@2|Bacteria,1RJ21@1224|Proteobacteria,430EX@68525|delta/epsilon subdivisions,2WVVF@28221|Deltaproteobacteria,2YUQK@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1674446_7	448385.sce3758	5.54e-44	166.0	COG2952@1|root,COG2952@2|Bacteria,1QJIU@1224|Proteobacteria,43826@68525|delta/epsilon subdivisions,2X3CC@28221|Deltaproteobacteria,2YVDW@29|Myxococcales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF507)	-	-	-	ko:K09804	-	-	-	-	ko00000	-	-	-	DUF507
HKD2_k127_1674446_5	1254432.SCE1572_22625	2.052e-66	237.0	COG1561@1|root,COG1561@2|Bacteria,1MWRA@1224|Proteobacteria,42RFR@68525|delta/epsilon subdivisions,2WJYK@28221|Deltaproteobacteria,2YVIN@29|Myxococcales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF1732)	yicC	-	-	-	-	-	-	-	-	-	-	-	DUF1732,YicC_N
HKD2_k127_1674446_4	1192034.CAP_6917	3.233e-70	243.0	COG0194@1|root,COG0194@2|Bacteria,1MW92@1224|Proteobacteria,42R4H@68525|delta/epsilon subdivisions,2WNAD@28221|Deltaproteobacteria,2YV51@29|Myxococcales	28221|Deltaproteobacteria	F	Essential for recycling GMP and indirectly, cGMP	gmk	GO:0003674,GO:0003824,GO:0004385,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009150,GO:0009161,GO:0009165,GO:0009167,GO:0009179,GO:0009185,GO:0009259,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0042278,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046483,GO:0046710,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901657	2.7.4.8	ko:K00942	ko00230,ko01100,map00230,map01100	M00050	R00332,R02090	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_kin
HKD2_k127_1674446_2	330214.NIDE3354	3.023e-91	318.0	COG0005@1|root,COG0005@2|Bacteria,3J0HC@40117|Nitrospirae	40117|Nitrospirae	F	Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates	mtnP	-	2.4.2.28	ko:K00772	ko00270,ko01100,map00270,map01100	M00034	R01402	RC00063,RC02819	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
HKD2_k127_1674446_1	448385.sce3764	3.116e-111	368.0	COG0524@1|root,COG0524@2|Bacteria,1Q8Y3@1224|Proteobacteria,42NSV@68525|delta/epsilon subdivisions,2WJWD@28221|Deltaproteobacteria,2YU0F@29|Myxococcales	28221|Deltaproteobacteria	G	pfkB family carbohydrate kinase	-	-	-	-	-	-	-	-	-	-	-	iAF987.Gmet_2683	PfkB
HKD2_k127_1675035_8	215803.DB30_0855	1.92e-15	88.0	COG0491@1|root,COG0491@2|Bacteria,1Q427@1224|Proteobacteria,439VM@68525|delta/epsilon subdivisions,2X59N@28221|Deltaproteobacteria,2Z0AV@29|Myxococcales	28221|Deltaproteobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HKD2_k127_1675035_3	404589.Anae109_4233	4.119e-76	271.0	COG1752@1|root,COG1752@2|Bacteria,1RCDG@1224|Proteobacteria,43963@68525|delta/epsilon subdivisions,2X4CS@28221|Deltaproteobacteria,2YYRY@29|Myxococcales	28221|Deltaproteobacteria	S	Patatin-like phospholipase	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
HKD2_k127_1675035_2	1254432.SCE1572_36790	4.583e-143	466.0	COG1073@1|root,COG1926@1|root,COG1073@2|Bacteria,COG1926@2|Bacteria,1RDAY@1224|Proteobacteria,42RP4@68525|delta/epsilon subdivisions,2WPU8@28221|Deltaproteobacteria,2YWQD@29|Myxococcales	28221|Deltaproteobacteria	S	Dienelactone hydrolase family	-	-	-	ko:K07100	-	-	-	-	ko00000	-	-	-	DLH,Pribosyltran
HKD2_k127_1675035_0	1242864.D187_001522	2.419e-176	567.0	COG0277@1|root,COG0277@2|Bacteria,1N4UQ@1224|Proteobacteria,43427@68525|delta/epsilon subdivisions,2X4S9@28221|Deltaproteobacteria,2YZHJ@29|Myxococcales	28221|Deltaproteobacteria	C	FAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_4
HKD2_k127_1675035_1	1128421.JAGA01000003_gene2830	2.526e-163	527.0	COG1690@1|root,COG1690@2|Bacteria,2NNVX@2323|unclassified Bacteria	2|Bacteria	S	Belongs to the RtcB family	rtcB	-	6.5.1.3	ko:K14415	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RtcB
HKD2_k127_1675035_10	869210.Marky_0193	2.409e-05	54.0	COG1371@1|root,COG1371@2|Bacteria,1WJYM@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Archease protein family (MTH1598/TM1083)	-	-	-	-	-	-	-	-	-	-	-	-	Archease
HKD2_k127_1675035_5	398525.KB900701_gene6538	4.987e-51	186.0	COG0778@1|root,COG0778@2|Bacteria,1PEMB@1224|Proteobacteria,2V61J@28211|Alphaproteobacteria,3JYA5@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
HKD2_k127_1675035_7	472759.Nhal_1885	6.657e-21	99.0	COG0517@1|root,COG0517@2|Bacteria,1QTVM@1224|Proteobacteria,1SFWU@1236|Gammaproteobacteria,1X1W5@135613|Chromatiales	135613|Chromatiales	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
HKD2_k127_1675035_6	448385.sce1078	6.234e-29	126.0	COG0558@1|root,COG0558@2|Bacteria,1P9BV@1224|Proteobacteria,432CD@68525|delta/epsilon subdivisions,2WX7J@28221|Deltaproteobacteria,2YW7B@29|Myxococcales	28221|Deltaproteobacteria	I	CDP-alcohol phosphatidyltransferase	-	-	2.7.8.41,2.7.8.5	ko:K00995,ko:K08744	ko00564,ko01100,map00564,map01100	-	R01801,R02030	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
HKD2_k127_1675035_4	1254432.SCE1572_36710	4.535e-52	186.0	COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,42M52@68525|delta/epsilon subdivisions,2WIRK@28221|Deltaproteobacteria,2YUQN@29|Myxococcales	28221|Deltaproteobacteria	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	-	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
HKD2_k127_1680574_14	926566.Terro_2909	2.323e-24	119.0	COG3118@1|root,COG3118@2|Bacteria,3Y69N@57723|Acidobacteria,2JMI3@204432|Acidobacteriia	204432|Acidobacteriia	O	ASPIC and UnbV	-	-	-	-	-	-	-	-	-	-	-	-	UnbV_ASPIC,VCBS
HKD2_k127_1680574_11	391625.PPSIR1_19174	1.937e-29	132.0	COG0607@1|root,COG0607@2|Bacteria,1MZPW@1224|Proteobacteria,42NX5@68525|delta/epsilon subdivisions,2WMJ4@28221|Deltaproteobacteria,2Z1G5@29|Myxococcales	28221|Deltaproteobacteria	P	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese,Rubrerythrin
HKD2_k127_1680574_13	1288826.MSNKSG1_14212	1.396e-26	123.0	2DE7S@1|root,2ZKW3@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1680574_16	1192034.CAP_0201	7.491e-08	64.0	COG3221@1|root,COG3221@2|Bacteria,1MXD8@1224|Proteobacteria,42VZ4@68525|delta/epsilon subdivisions,2WRDI@28221|Deltaproteobacteria,2YW4T@29|Myxococcales	28221|Deltaproteobacteria	P	ABC transporter, phosphonate, periplasmic substrate-binding protein	phnD	-	-	ko:K02044	ko02010,map02010	M00223	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.9	-	-	Phosphonate-bd
HKD2_k127_1680574_8	314278.NB231_04630	1.563e-73	255.0	COG0378@1|root,COG0378@2|Bacteria,1MVBD@1224|Proteobacteria,1RN9Y@1236|Gammaproteobacteria,1WWGI@135613|Chromatiales	135613|Chromatiales	KO	TIGRFAM Hydrogenase accessory protein HypB	-	-	-	ko:K04652	-	-	-	-	ko00000,ko03110	-	-	-	cobW
HKD2_k127_1680574_2	215803.DB30_0109	3.745e-168	552.0	COG0068@1|root,COG0068@2|Bacteria,1MVP8@1224|Proteobacteria,42M3G@68525|delta/epsilon subdivisions,2WJ51@28221|Deltaproteobacteria,2YTV0@29|Myxococcales	28221|Deltaproteobacteria	O	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide	hypF	-	-	ko:K04656	-	-	-	-	ko00000	-	-	-	Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF
HKD2_k127_1680574_12	1163617.SCD_n00325	1.007e-26	120.0	2B47E@1|root,31WYM@2|Bacteria,1R5Q0@1224|Proteobacteria,2VT47@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1680574_7	1192034.CAP_0097	5.295e-87	303.0	COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,42NTG@68525|delta/epsilon subdivisions,2X5CT@28221|Deltaproteobacteria,2YV0W@29|Myxococcales	28221|Deltaproteobacteria	Q	ABC transporter	-	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
HKD2_k127_1680574_15	383372.Rcas_3586	1.308e-13	82.0	COG3025@1|root,COG5607@1|root,COG3025@2|Bacteria,COG5607@2|Bacteria,2G7FA@200795|Chloroflexi,375SS@32061|Chloroflexia	32061|Chloroflexia	FP	PFAM CHAD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CHAD,CYTH,HD
HKD2_k127_1680574_10	391625.PPSIR1_41689	1.058e-48	186.0	2DDNF@1|root,2ZIP8@2|Bacteria,1P069@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1680574_6	1304874.JAFY01000005_gene1474	7.422e-112	372.0	COG1087@1|root,COG1087@2|Bacteria,3T9XG@508458|Synergistetes	508458|Synergistetes	M	UDP-glucose 4-epimerase	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
HKD2_k127_1680574_3	1254432.SCE1572_30295	8.694e-135	464.0	COG0438@1|root,COG0438@2|Bacteria,1QU2N@1224|Proteobacteria,43DMV@68525|delta/epsilon subdivisions,2X6DD@28221|Deltaproteobacteria,2Z2W1@29|Myxococcales	1224|Proteobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase,Glyco_trans_1_4,NAD_binding_8
HKD2_k127_1680574_1	1254432.SCE1572_30290	1.669e-189	622.0	COG0562@1|root,COG0562@2|Bacteria,1MV4H@1224|Proteobacteria,42NAB@68525|delta/epsilon subdivisions,2WUXH@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	UDP-galactopyranose mutase	-	-	5.4.99.9	ko:K01854	ko00052,ko00520,map00052,map00520	-	R00505,R09009	RC00317,RC02396	ko00000,ko00001,ko01000	-	-	-	GLF,NAD_binding_8
HKD2_k127_1680574_0	1254432.SCE1572_30285	7.442e-262	839.0	COG3250@1|root,COG3250@2|Bacteria,1MVBN@1224|Proteobacteria,42ZMW@68525|delta/epsilon subdivisions,2WUW2@28221|Deltaproteobacteria,2YX4S@29|Myxococcales	28221|Deltaproteobacteria	G	Belongs to the glycosyl hydrolase 2 family	-	-	-	-	-	-	-	-	-	-	-	-	AbfB,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N
HKD2_k127_1680574_4	221288.JH992901_gene4621	1.405e-132	441.0	COG1085@1|root,COG1085@2|Bacteria,1G1PF@1117|Cyanobacteria,1JKKI@1189|Stigonemataceae	1117|Cyanobacteria	C	Galactose-1-phosphate uridyl transferase, C-terminal domain	-	-	2.7.7.12	ko:K00965	ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917	M00362,M00554,M00632	R00955	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	GalP_UDP_tr_C,GalP_UDP_transf
HKD2_k127_1680574_5	448385.sce2225	2.164e-119	393.0	COG0153@1|root,COG0153@2|Bacteria,1MVQD@1224|Proteobacteria,42Y39@68525|delta/epsilon subdivisions,2WSYZ@28221|Deltaproteobacteria,2YV2T@29|Myxococcales	28221|Deltaproteobacteria	G	Belongs to the GHMP kinase family. GalK subfamily	galK	-	2.7.1.6	ko:K00849	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00554,M00632	R01092	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	GHMP_kinases_C,GHMP_kinases_N,GalKase_gal_bdg
HKD2_k127_1680574_9	204669.Acid345_0731	9.489e-49	193.0	COG3511@1|root,COG3511@2|Bacteria,3Y7AQ@57723|Acidobacteria,2JM7S@204432|Acidobacteriia	2|Bacteria	M	Phosphoesterase family	-	-	3.1.4.3	ko:K01114	ko00562,ko00564,ko00565,ko01100,ko01110,ko02024,ko04919,map00562,map00564,map00565,map01100,map01110,map02024,map04919	-	R01312,R02027,R02052,R03332,R07381	RC00017,RC00425	ko00000,ko00001,ko01000,ko02042	-	-	-	Phosphoesterase
HKD2_k127_1689827_0	1430440.MGMSRv2_1430	3.081e-257	808.0	COG4263@1|root,COG4263@2|Bacteria,1MVIH@1224|Proteobacteria,2TTB5@28211|Alphaproteobacteria,2JR4S@204441|Rhodospirillales	204441|Rhodospirillales	C	Nitrous-oxide reductase is part of a bacterial respiratory system which is activated under anaerobic conditions in the presence of nitrate or nitrous oxide	nosZ	-	1.7.2.4	ko:K00376	ko00910,ko01120,map00910,map01120	M00529	R02804	RC02861	ko00000,ko00001,ko00002,ko01000	-	-	-	Cupredoxin_1
HKD2_k127_1689827_2	309801.trd_A0193	8.349e-38	151.0	COG4314@1|root,COG4314@2|Bacteria,2G8NV@200795|Chloroflexi,27Z7G@189775|Thermomicrobia	189775|Thermomicrobia	C	lipoprotein involved in nitrous oxide reduction	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1689827_1	518766.Rmar_2014	1.115e-39	166.0	COG3420@1|root,COG3420@2|Bacteria,4NEGT@976|Bacteroidetes,1FJC4@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	P	Domain present in carbohydrate binding proteins and sugar hydrolses	nosD	-	-	ko:K07218	-	-	-	-	ko00000	-	-	-	NosD
HKD2_k127_169442_11	1125863.JAFN01000001_gene1503	8.413e-15	81.0	COG3209@1|root,COG3291@1|root,COG3209@2|Bacteria,COG3291@2|Bacteria,1R5MU@1224|Proteobacteria,42UIQ@68525|delta/epsilon subdivisions,2WQAN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Repeats in polycystic kidney disease 1 (PKD1) and other proteins	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_169442_16	1382359.JIAL01000001_gene792	1.519e-08	64.0	COG3678@1|root,COG3678@2|Bacteria,3Y5A6@57723|Acidobacteria,2JJQD@204432|Acidobacteriia	204432|Acidobacteriia	NPTU	Heavy-metal resistance	-	-	-	-	-	-	-	-	-	-	-	-	Metal_resist
HKD2_k127_169442_17	596152.DesU5LDRAFT_3512	5.062e-08	56.0	COG1028@1|root,COG1028@2|Bacteria,1MVA5@1224|Proteobacteria,42S56@68525|delta/epsilon subdivisions,2WNHZ@28221|Deltaproteobacteria,2MCI4@213115|Desulfovibrionales	28221|Deltaproteobacteria	IQ	KR domain	-	-	1.1.1.30	ko:K00019	ko00072,ko00650,ko01100,map00072,map00650,map01100	M00088	R01361	RC00117	ko00000,ko00001,ko00002,ko01000	-	-	-	adh_short,adh_short_C2
HKD2_k127_169442_8	661367.LLO_1083	1.758e-20	107.0	COG4447@1|root,COG4447@2|Bacteria,1R1E3@1224|Proteobacteria	1224|Proteobacteria	DZ	regulator of chromosome condensation, RCC1	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_169442_2	926566.Terro_1937	8.469e-98	344.0	COG2374@1|root,COG2374@2|Bacteria,3Y6CB@57723|Acidobacteria,2JMEK@204432|Acidobacteriia	204432|Acidobacteriia	S	Endonuclease Exonuclease Phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_169442_10	215803.DB30_4298	4.056e-16	93.0	COG4447@1|root,COG4447@2|Bacteria,1PK4F@1224|Proteobacteria,437G7@68525|delta/epsilon subdivisions,2XA3A@28221|Deltaproteobacteria,2YVKV@29|Myxococcales	28221|Deltaproteobacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_169442_19	1163408.UU9_00120	8.214e-07	53.0	COG3179@1|root,COG3409@1|root,COG3179@2|Bacteria,COG3409@2|Bacteria,1RC1P@1224|Proteobacteria,1S335@1236|Gammaproteobacteria,1XCBE@135614|Xanthomonadales	135614|Xanthomonadales	M	Chitinase class I	-	-	-	ko:K03791	-	-	-	-	ko00000	-	GH19	-	Glyco_hydro_19,PG_binding_1
HKD2_k127_169442_1	448385.sce8814	2.069e-119	412.0	COG1858@1|root,COG3391@1|root,COG1858@2|Bacteria,COG3391@2|Bacteria,1R7E0@1224|Proteobacteria,42XD8@68525|delta/epsilon subdivisions,2WT8U@28221|Deltaproteobacteria,2YV4I@29|Myxococcales	28221|Deltaproteobacteria	C	TIGRFAM 40-residue YVTN family beta-propeller repeat	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,Cytochrome_C7
HKD2_k127_169442_4	502025.Hoch_4645	4.066e-63	239.0	COG0784@1|root,COG2197@1|root,COG4191@1|root,COG0784@2|Bacteria,COG2197@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42Q3F@68525|delta/epsilon subdivisions,2WM2F@28221|Deltaproteobacteria,2YUEQ@29|Myxococcales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_8,PAS_9,Response_reg
HKD2_k127_169442_9	56107.Cylst_0496	8.815e-17	95.0	COG0332@1|root,COG0332@2|Bacteria,1G3ZE@1117|Cyanobacteria,1HK7D@1161|Nostocales	1117|Cyanobacteria	I	3-Oxoacyl- acyl-carrier-protein (ACP) synthase III C terminal	-	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
HKD2_k127_169442_0	448385.sce8755	2.058e-196	629.0	COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,42M1X@68525|delta/epsilon subdivisions,2WJA2@28221|Deltaproteobacteria,2Z07R@29|Myxococcales	28221|Deltaproteobacteria	EH	Belongs to the TPP enzyme family	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
HKD2_k127_169442_3	1254432.SCE1572_27170	9.876e-84	295.0	COG0568@1|root,COG0568@2|Bacteria,1MVNJ@1224|Proteobacteria,42N2S@68525|delta/epsilon subdivisions,2WJ0E@28221|Deltaproteobacteria,2YUHI@29|Myxococcales	28221|Deltaproteobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	rpoD	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_ner,Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
HKD2_k127_169442_6	448385.sce1876	1.077e-24	107.0	COG0724@1|root,COG0724@2|Bacteria	2|Bacteria	K	RNA recognition motif	grp	-	-	-	-	-	-	-	-	-	-	-	RRM_1
HKD2_k127_169442_15	292.DM42_3390	6.146e-09	66.0	COG4675@1|root,COG4675@2|Bacteria,1N9EK@1224|Proteobacteria	1224|Proteobacteria	S	cellulase activity	-	-	-	-	-	-	-	-	-	-	-	-	Collar,Phage_fiber_2
HKD2_k127_169442_7	1242864.D187_009333	8.641e-24	117.0	COG5492@1|root,COG5492@2|Bacteria,1NH4T@1224|Proteobacteria	1224|Proteobacteria	N	Polysaccharide lyase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_lyase
HKD2_k127_169442_18	526227.Mesil_2845	3.317e-07	61.0	COG1266@1|root,COG1266@2|Bacteria	2|Bacteria	V	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
HKD2_k127_169442_12	1249480.B649_03140	7.194e-13	79.0	COG0739@1|root,COG0739@2|Bacteria,1N19D@1224|Proteobacteria,42SMK@68525|delta/epsilon subdivisions,2YTS0@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	M	Peptidase family M23	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
HKD2_k127_169442_5	1033802.SSPSH_001443	1.088e-43	167.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD2_k127_1695474_0	1192034.CAP_5023	1.035e-209	691.0	COG0457@1|root,COG0457@2|Bacteria,1PXR4@1224|Proteobacteria,43DWZ@68525|delta/epsilon subdivisions,2WZ3E@28221|Deltaproteobacteria,2Z18R@29|Myxococcales	28221|Deltaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1695474_1	1192034.CAP_6257	2.271e-29	118.0	COG1217@1|root,COG1217@2|Bacteria,1MV5Q@1224|Proteobacteria,42M3S@68525|delta/epsilon subdivisions,2WJVZ@28221|Deltaproteobacteria,2YU94@29|Myxococcales	28221|Deltaproteobacteria	T	GTP-binding protein	typA	-	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2
HKD2_k127_1721886_3	1150599.MPHLEI_21434	8.436e-64	250.0	COG2723@1|root,COG2723@2|Bacteria,2GJAF@201174|Actinobacteria,235G0@1762|Mycobacteriaceae	201174|Actinobacteria	G	Glycosyl hydrolase family 1	bglA	-	3.2.1.21	ko:K05350	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_1
HKD2_k127_1721886_1	1463858.JOHR01000001_gene6186	1.05e-106	379.0	COG2303@1|root,COG2303@2|Bacteria,2I5YA@201174|Actinobacteria	2|Bacteria	E	oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GMC_oxred_C
HKD2_k127_1721886_9	1265490.JHVY01000007_gene1655	4.451e-06	57.0	2DB8V@1|root,2Z7SX@2|Bacteria,1MX06@1224|Proteobacteria,1RQ6Y@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Gluconate 2-dehydrogenase	-	-	1.1.99.3	ko:K06152	ko00030,ko01100,ko01120,map00030,map01100,map01120	-	R01741	RC00084	ko00000,ko00001,ko01000	-	-	-	Gluconate_2-dh3
HKD2_k127_1721886_8	485913.Krac_4700	9.848e-15	87.0	2DRZ7@1|root,33DSV@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1721886_2	1173263.Syn7502_02854	2.532e-87	297.0	COG4798@1|root,COG4798@2|Bacteria,1GCU2@1117|Cyanobacteria	1117|Cyanobacteria	S	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1721886_5	395495.Lcho_0451	1.148e-53	201.0	COG0697@1|root,COG0803@1|root,COG0697@2|Bacteria,COG0803@2|Bacteria,1N3FA@1224|Proteobacteria,2VHAD@28216|Betaproteobacteria,1KJHJ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	EG	DMT(Drug metabolite transporter) superfamily permease	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HKD2_k127_1721886_6	1123376.AUIU01000014_gene712	5.639e-37	146.0	COG0693@1|root,COG0693@2|Bacteria	2|Bacteria	S	protein deglycation	pfpI3	-	2.7.11.1,3.5.1.124	ko:K03152,ko:K05520,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001,ko01002	-	-	-	DJ-1_PfpI
HKD2_k127_1721886_0	1144275.COCOR_04407	2.363e-120	400.0	COG2843@1|root,COG2843@2|Bacteria,1P1MG@1224|Proteobacteria,42MEY@68525|delta/epsilon subdivisions,2WM0F@28221|Deltaproteobacteria,2YXA9@29|Myxococcales	28221|Deltaproteobacteria	M	Bacterial capsule synthesis protein PGA_cap	-	-	-	ko:K07282	-	-	-	-	ko00000	-	-	-	PGA_cap
HKD2_k127_1721886_4	711393.AYRX01000083_gene4764	6.262e-58	209.0	2B37N@1|root,31VVP@2|Bacteria,2GWAN@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
HKD2_k127_1723701_2	178901.AmDm5_3062	1.433e-27	129.0	COG0770@1|root,COG0770@2|Bacteria,1QTSF@1224|Proteobacteria,2TR0Q@28211|Alphaproteobacteria,2JQZC@204441|Rhodospirillales	204441|Rhodospirillales	M	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein	murF	-	6.3.2.10	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	-	R04573,R04617	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
HKD2_k127_1723701_0	391625.PPSIR1_16910	6.819e-56	211.0	COG0539@1|root,COG0539@2|Bacteria,1N2EJ@1224|Proteobacteria,42NXS@68525|delta/epsilon subdivisions,2WJ0A@28221|Deltaproteobacteria,2YV19@29|Myxococcales	28221|Deltaproteobacteria	J	Ribosomal protein S1-like RNA-binding domain	-	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
HKD2_k127_1723701_4	448385.sce3023	5.005e-07	59.0	2BQRM@1|root,32JN9@2|Bacteria,1PDHV@1224|Proteobacteria,435GS@68525|delta/epsilon subdivisions,2WZUA@28221|Deltaproteobacteria,2Z2RV@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1723701_3	525904.Tter_2127	2.444e-24	112.0	COG4097@1|root,COG4097@2|Bacteria	2|Bacteria	P	nitric oxide dioxygenase activity	-	-	-	ko:K17247	-	-	-	-	ko00000	-	-	-	Ferric_reduct
HKD2_k127_1723701_1	326427.Cagg_0542	1.452e-37	150.0	COG1477@1|root,COG1477@2|Bacteria,2G6WH@200795|Chloroflexi,375JB@32061|Chloroflexia	32061|Chloroflexia	H	Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein	-	-	2.7.1.180	ko:K03734	-	-	-	-	ko00000,ko01000	-	-	-	ApbE
HKD2_k127_1729262_2	392499.Swit_1811	1.414e-30	129.0	COG3233@1|root,COG3233@2|Bacteria,1RIED@1224|Proteobacteria,2VERK@28211|Alphaproteobacteria,2KDTE@204457|Sphingomonadales	204457|Sphingomonadales	S	Uncharacterized protein conserved in bacteria (DUF2334)	-	-	-	ko:K06986	-	-	-	-	ko00000	-	-	-	DUF2334
HKD2_k127_1729262_1	1254432.SCE1572_07390	6.484e-65	239.0	COG0438@1|root,COG0438@2|Bacteria,1NU0D@1224|Proteobacteria,431K6@68525|delta/epsilon subdivisions,2WWVM@28221|Deltaproteobacteria,2Z1M9@29|Myxococcales	28221|Deltaproteobacteria	M	Glycosyltransferase Family 4	-	-	-	ko:K14335	-	-	-	-	ko00000,ko01000,ko01003	-	GT4	-	Glyco_transf_4,Glycos_transf_1
HKD2_k127_1729262_0	448385.sce1028	3.531e-67	235.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	gt4G	-	2.7.1.33	ko:K03525	ko00770,ko01100,map00770,map01100	M00120	R02971,R03018,R04391	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
HKD2_k127_173215_4	518766.Rmar_0491	1.12e-44	167.0	COG4146@1|root,COG4146@2|Bacteria,4NE9S@976|Bacteroidetes,1FJX9@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	S	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	-	-	-	ko:K03307	-	-	-	-	ko00000	2.A.21	-	-	SSF
HKD2_k127_173215_1	886293.Sinac_3058	2.272e-145	475.0	COG1249@1|root,COG1249@2|Bacteria,2IY39@203682|Planctomycetes	203682|Planctomycetes	C	Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase	sthA	-	1.6.1.1	ko:K00322	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_dim
HKD2_k127_173215_0	1254432.SCE1572_17585	4.426e-224	701.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2YTY9@29|Myxococcales	28221|Deltaproteobacteria	T	response regulator	-	-	-	ko:K07714	ko02020,map02020	M00500	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD2_k127_173215_3	1192034.CAP_7257	2.951e-68	259.0	COG1470@1|root,COG1470@2|Bacteria,1P6QQ@1224|Proteobacteria,4385T@68525|delta/epsilon subdivisions,2X3FM@28221|Deltaproteobacteria,2YVWE@29|Myxococcales	28221|Deltaproteobacteria	S	cell adhesion involved in biofilm formation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_173215_5	864069.MicloDRAFT_00010630	2.056e-35	138.0	COG2261@1|root,COG2261@2|Bacteria,1NNKP@1224|Proteobacteria,2UGGY@28211|Alphaproteobacteria,1JW92@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	Transglycosylase associated protein	-	-	-	-	-	-	-	-	-	-	-	-	Transgly_assoc
HKD2_k127_173215_2	448385.sce8063	6.323e-137	446.0	COG3876@1|root,COG3876@2|Bacteria,1MX3S@1224|Proteobacteria,42N6K@68525|delta/epsilon subdivisions,2WKFH@28221|Deltaproteobacteria,2YUIN@29|Myxococcales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF1343)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1343
HKD2_k127_173215_6	1144275.COCOR_02951	7.049e-06	49.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,42Q67@68525|delta/epsilon subdivisions,2WKZ1@28221|Deltaproteobacteria,2YUQ6@29|Myxococcales	28221|Deltaproteobacteria	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	AAA_16,Pkinase,TPR_12,zinc_ribbon_2
HKD2_k127_174420_0	1254432.SCE1572_14810	6.65e-209	671.0	COG1287@1|root,COG2203@1|root,COG3852@1|root,COG1287@2|Bacteria,COG2203@2|Bacteria,COG3852@2|Bacteria,1MVN6@1224|Proteobacteria,43BPS@68525|delta/epsilon subdivisions,2X710@28221|Deltaproteobacteria,2YU4V@29|Myxococcales	28221|Deltaproteobacteria	T	Signal transduction histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HATPase_c,HisKA
HKD2_k127_174420_1	1192034.CAP_0849	2.022e-124	408.0	COG1063@1|root,COG1063@2|Bacteria,1R8JQ@1224|Proteobacteria,4374D@68525|delta/epsilon subdivisions,2X3P4@28221|Deltaproteobacteria,2YWQG@29|Myxococcales	28221|Deltaproteobacteria	E	alcohol dehydrogenase	-	-	1.4.1.11	ko:K18012	ko00310,map00310	-	R03349	RC00888	ko00000,ko00001,ko01000	-	-	-	-
HKD2_k127_174420_2	378806.STAUR_2817	3.237e-39	161.0	COG1716@1|root,COG1716@2|Bacteria,1RAA4@1224|Proteobacteria,431UR@68525|delta/epsilon subdivisions,2WWZQ@28221|Deltaproteobacteria,2YU65@29|Myxococcales	28221|Deltaproteobacteria	T	FHA domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4388,FHA,Yop-YscD_cpl
HKD2_k127_1746660_11	448385.sce5854	3.242e-37	143.0	COG3215@1|root,COG3215@2|Bacteria,1Q2S4@1224|Proteobacteria,43266@68525|delta/epsilon subdivisions,2WXR8@28221|Deltaproteobacteria,2YVFJ@29|Myxococcales	28221|Deltaproteobacteria	NU	PilZ domain	-	-	-	ko:K02676	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilZ
HKD2_k127_1746660_2	1254432.SCE1572_43140	2.433e-152	485.0	COG0379@1|root,COG0379@2|Bacteria,1MWQU@1224|Proteobacteria,42N99@68525|delta/epsilon subdivisions,2WJY8@28221|Deltaproteobacteria,2YTVB@29|Myxococcales	28221|Deltaproteobacteria	H	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate	nadA	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008987,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016053,GO:0017144,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0019805,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046496,GO:0046874,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	2.5.1.72	ko:K03517	ko00760,ko01100,map00760,map01100	M00115	R04292	RC01119	ko00000,ko00001,ko00002,ko01000	-	-	-	NadA
HKD2_k127_1746660_5	926560.KE387027_gene532	5.824e-90	312.0	COG0654@1|root,COG0654@2|Bacteria,1WMEV@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	CH	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1746660_15	248742.XP_005645966.1	1.664e-15	88.0	2BN3S@1|root,2S52A@2759|Eukaryota,37W4N@33090|Viridiplantae	33090|Viridiplantae	S	stigma-specific Stig1 family protein	-	GO:0000003,GO:0000302,GO:0001101,GO:0003006,GO:0005575,GO:0005576,GO:0005615,GO:0006950,GO:0006952,GO:0006979,GO:0007154,GO:0007165,GO:0007275,GO:0008150,GO:0009605,GO:0009607,GO:0009617,GO:0009719,GO:0009725,GO:0009751,GO:0009753,GO:0009755,GO:0009791,GO:0009863,GO:0009867,GO:0009889,GO:0009987,GO:0010033,GO:0010035,GO:0010154,GO:0010193,GO:0010337,GO:0010565,GO:0010817,GO:0010941,GO:0010942,GO:0014070,GO:0019216,GO:0019217,GO:0019222,GO:0022414,GO:0023052,GO:0031323,GO:0031326,GO:0032350,GO:0032501,GO:0032502,GO:0032870,GO:0035690,GO:0042221,GO:0042304,GO:0042493,GO:0042742,GO:0043207,GO:0044421,GO:0046677,GO:0046885,GO:0046890,GO:0048316,GO:0048518,GO:0048522,GO:0048608,GO:0048731,GO:0048856,GO:0050789,GO:0050794,GO:0050896,GO:0051704,GO:0051707,GO:0051716,GO:0061458,GO:0062012,GO:0065007,GO:0065008,GO:0070887,GO:0071229,GO:0071236,GO:0071310,GO:0071395,GO:0071407,GO:0071446,GO:0071495,GO:0080090,GO:0080140,GO:0080141,GO:0080142,GO:0098542,GO:1901700,GO:1901701	-	-	-	-	-	-	-	-	-	-	Stig1
HKD2_k127_1746660_8	869210.Marky_0377	4.582e-72	267.0	COG2070@1|root,COG2070@2|Bacteria,1WIKI@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	2-Nitropropane dioxygenase	-	-	1.13.12.16	ko:K00459	ko00910,map00910	-	R00025	RC02541,RC02759	ko00000,ko00001,ko01000	-	-	-	NMO
HKD2_k127_1746660_12	290397.Adeh_0078	1.623e-30	129.0	2A9VF@1|root,30Z3B@2|Bacteria,1PKZS@1224|Proteobacteria,435JG@68525|delta/epsilon subdivisions,2WZXJ@28221|Deltaproteobacteria,2Z0YG@29|Myxococcales	290397.Adeh_0078|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1746660_13	1236976.JCM16418_539	1.301e-21	101.0	2DHJZ@1|root,3003A@2|Bacteria,1V677@1239|Firmicutes,4HHHJ@91061|Bacilli,26ZDH@186822|Paenibacillaceae	91061|Bacilli	S	Domain of unknown function (DUF5071)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5071
HKD2_k127_1746660_3	1192034.CAP_5909	7.356e-150	497.0	COG3291@1|root,COG3291@2|Bacteria,1QEIS@1224|Proteobacteria,4389M@68525|delta/epsilon subdivisions,2X3J1@28221|Deltaproteobacteria,2YWAB@29|Myxococcales	28221|Deltaproteobacteria	S	IgGFc binding protein	-	-	-	-	-	-	-	-	-	-	-	-	IgGFc_binding
HKD2_k127_1746660_14	1110697.NCAST_32_09590	8.379e-20	106.0	COG3693@1|root,COG3693@2|Bacteria,2GN8V@201174|Actinobacteria,4G8IJ@85025|Nocardiaceae	201174|Actinobacteria	G	Belongs to the glycosyl hydrolase 5 (cellulase A) family	-	-	-	-	-	-	-	-	-	-	-	-	Cellulase,Glyco_hydro_42,Glyco_hydro_cc
HKD2_k127_1746660_18	360910.BAV0254	0.0001	52.0	COG1396@1|root,COG1396@2|Bacteria,1QU8X@1224|Proteobacteria,2VT1E@28216|Betaproteobacteria	28216|Betaproteobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
HKD2_k127_1746660_9	1192034.CAP_7899	4.345e-48	183.0	COG0631@1|root,COG0631@2|Bacteria,1NCRX@1224|Proteobacteria,43ABC@68525|delta/epsilon subdivisions,2X2PV@28221|Deltaproteobacteria,2Z0FJ@29|Myxococcales	28221|Deltaproteobacteria	T	Serine/threonine phosphatases, family 2C, catalytic domain	-	-	3.1.3.16	ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C_2
HKD2_k127_1746660_7	1254432.SCE1572_39620	4.135e-72	254.0	COG0515@1|root,COG3899@1|root,COG0515@2|Bacteria,COG3899@2|Bacteria	1254432.SCE1572_39620|-	T	PFAM Protein kinase domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1746660_6	448385.sce8301	6.281e-79	274.0	COG0767@1|root,COG0767@2|Bacteria,1MVPN@1224|Proteobacteria,42MR1@68525|delta/epsilon subdivisions,2WKC9@28221|Deltaproteobacteria,2YV04@29|Myxococcales	28221|Deltaproteobacteria	Q	COG0767 ABC-type transport system involved in resistance to organic solvents, permease component	-	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE
HKD2_k127_1746660_4	1254432.SCE1572_42260	9.696e-131	433.0	COG0787@1|root,COG0787@2|Bacteria,1MV0Q@1224|Proteobacteria,42MGU@68525|delta/epsilon subdivisions,2WIVG@28221|Deltaproteobacteria,2YZJS@29|Myxococcales	28221|Deltaproteobacteria	M	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids	alr	-	5.1.1.1	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	-	R00401	RC00285	ko00000,ko00001,ko01000,ko01011	-	-	-	Ala_racemase_C,Ala_racemase_N
HKD2_k127_1746660_0	1254432.SCE1572_00085	6.227e-209	667.0	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,42N2U@68525|delta/epsilon subdivisions,2WJRR@28221|Deltaproteobacteria,2YXAZ@29|Myxococcales	28221|Deltaproteobacteria	P	ABC transporter transmembrane region	msbA1	-	-	ko:K06147,ko:K18890	ko02010,map02010	M00707	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.106,3.A.1.106.13,3.A.1.106.5,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
HKD2_k127_1746660_1	1192034.CAP_3107	1.602e-207	670.0	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,42NCR@68525|delta/epsilon subdivisions,2WKMY@28221|Deltaproteobacteria,2YWGZ@29|Myxococcales	28221|Deltaproteobacteria	P	ABC transporter	-	-	-	ko:K06147,ko:K18889	ko02010,map02010	M00707	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.106,3.A.1.106.13,3.A.1.106.5,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
HKD2_k127_1752184_2	1254432.SCE1572_11855	2.44e-10	70.0	COG3391@1|root,COG3391@2|Bacteria,1Q2JN@1224|Proteobacteria,4386H@68525|delta/epsilon subdivisions,2X9ZH@28221|Deltaproteobacteria,2YVZH@29|Myxococcales	28221|Deltaproteobacteria	S	Beta-L-arabinofuranosidase, GH127	-	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3,Stig1
HKD2_k127_1752184_0	1192034.CAP_3724	6.853e-195	632.0	COG0457@1|root,COG0457@2|Bacteria	1192034.CAP_3724|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1752184_1	1313421.JHBV01000010_gene4166	7.505e-36	138.0	COG1028@1|root,COG1028@2|Bacteria,4NE45@976|Bacteroidetes,1IR0M@117747|Sphingobacteriia	976|Bacteroidetes	IQ	short-chain dehydrogenase	ykuF	-	-	ko:K13774	ko00281,map00281	-	R08087,R08096,R10125,R10126	RC00080,RC00087	ko00000,ko00001	-	-	-	adh_short_C2
HKD2_k127_1773818_0	880073.Calab_2460	2.77e-163	523.0	COG0446@1|root,COG0446@2|Bacteria,2NPPU@2323|unclassified Bacteria	2|Bacteria	S	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.5.4	ko:K17218	ko00920,map00920	-	R10152	RC03155	ko00000,ko00001,ko01000	-	-	-	DsrC,Pyr_redox_2
HKD2_k127_1773818_1	926569.ANT_27630	1.816e-17	97.0	COG2920@1|root,COG2920@2|Bacteria,2G9BI@200795|Chloroflexi	200795|Chloroflexi	P	DsrC like protein	dsrC	-	-	ko:K11179	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	DsrC
HKD2_k127_1773818_2	926550.CLDAP_11590	1.612e-06	50.0	COG2210@1|root,COG2210@2|Bacteria,2G77F@200795|Chloroflexi	200795|Chloroflexi	S	DsrE/DsrF/DrsH-like family	-	-	-	-	-	-	-	-	-	-	-	-	DrsE_2
HKD2_k127_1780226_3	204669.Acid345_4441	1.606e-59	212.0	2DNAS@1|root,32WH6@2|Bacteria,3Y5UC@57723|Acidobacteria,2JKNS@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1780226_1	234267.Acid_3960	8.46e-141	458.0	COG0111@1|root,COG0111@2|Bacteria,3Y7TQ@57723|Acidobacteria	57723|Acidobacteria	EH	D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding	-	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
HKD2_k127_1780226_2	1192034.CAP_0612	5.601e-73	276.0	COG0515@1|root,COG0515@2|Bacteria	1192034.CAP_0612|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1780226_4	1192034.CAP_3157	8.7e-40	167.0	COG4105@1|root,COG4105@2|Bacteria	2|Bacteria	S	cell envelope organization	bamD	-	-	ko:K05807,ko:K08309	-	-	-	-	ko00000,ko01000,ko01011,ko02000	1.B.33.1	GH23	-	YfiO
HKD2_k127_1780226_6	565045.NOR51B_964	1.073e-06	62.0	COG1361@1|root,COG1361@2|Bacteria	2|Bacteria	M	extracellular matrix structural constituent	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,DUF11,DUF4157,PMT_2,WD40
HKD2_k127_1780226_7	1033738.CAEP01000054_gene3899	2.369e-05	57.0	28JXC@1|root,2Z9MV@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DisA_N
HKD2_k127_1780226_5	585531.HMPREF0063_12737	2.464e-13	83.0	COG0745@1|root,COG0745@2|Bacteria,2GIZB@201174|Actinobacteria,4DP6U@85009|Propionibacteriales	201174|Actinobacteria	T	Transcriptional regulatory protein, C terminal	mprA	GO:0000160,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006355,GO:0007154,GO:0007165,GO:0008150,GO:0009268,GO:0009628,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010446,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0016020,GO:0019219,GO:0019222,GO:0023052,GO:0030312,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0035556,GO:0043254,GO:0044087,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0090034,GO:0097159,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2001141	-	ko:K07669,ko:K07672	ko02020,map02020	M00460,M00463	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
HKD2_k127_1780226_0	644968.DFW101_3063	9.169e-159	533.0	COG0642@1|root,COG0642@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,42M0Y@68525|delta/epsilon subdivisions,2WIR4@28221|Deltaproteobacteria,2M7T3@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF4118,HATPase_c,HisKA,PAS_3,PAS_9,Response_reg
HKD2_k127_178442_1	1192034.CAP_7992	1.433e-39	149.0	COG2719@1|root,COG2719@2|Bacteria,1MW6U@1224|Proteobacteria,42MYY@68525|delta/epsilon subdivisions,2WJ6V@28221|Deltaproteobacteria,2YUGF@29|Myxococcales	28221|Deltaproteobacteria	S	SpoVR like protein	spoVR	-	-	ko:K06415	-	-	-	-	ko00000	-	-	-	SpoVR
HKD2_k127_178442_0	1254432.SCE1572_11040	2.027e-74	264.0	COG0457@1|root,COG0457@2|Bacteria,1PEH7@1224|Proteobacteria,42TVC@68525|delta/epsilon subdivisions,2WSCX@28221|Deltaproteobacteria,2YZCB@29|Myxococcales	28221|Deltaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_14,TPR_16,TPR_2,TPR_8
HKD2_k127_178442_2	448385.sce3808	8.896e-33	128.0	COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,42V0K@68525|delta/epsilon subdivisions,2WR92@28221|Deltaproteobacteria,2Z1SJ@29|Myxococcales	28221|Deltaproteobacteria	K	Cold shock protein	-	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
HKD2_k127_178442_3	1415630.U771_13540	7.649e-18	89.0	2ARF7@1|root,31GRD@2|Bacteria,1P9JM@1224|Proteobacteria,1SV3T@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_178442_4	290397.Adeh_0989	1.145e-06	51.0	COG1409@1|root,COG1409@2|Bacteria,1MXD6@1224|Proteobacteria,42WZF@68525|delta/epsilon subdivisions,2WTE8@28221|Deltaproteobacteria,2Z34X@29|Myxococcales	28221|Deltaproteobacteria	S	Calcineurin-like phosphoesterase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
HKD2_k127_1786676_3	1254432.SCE1572_38080	9.594e-96	317.0	COG0473@1|root,COG0473@2|Bacteria,1QU2H@1224|Proteobacteria,43B0A@68525|delta/epsilon subdivisions,2X6EE@28221|Deltaproteobacteria,2YUMP@29|Myxococcales	28221|Deltaproteobacteria	C	Dehydrogenase	leuB2	-	1.1.1.41,1.1.1.85	ko:K00030,ko:K00052	ko00020,ko00290,ko00660,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00290,map00660,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00432,M00535	R00709,R00994,R04426,R10052	RC00084,RC00114,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
HKD2_k127_1786676_1	1278073.MYSTI_00197	3.868e-126	426.0	COG0784@1|root,COG2203@1|root,COG4191@1|root,COG0784@2|Bacteria,COG2203@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42PZ5@68525|delta/epsilon subdivisions,2WKB1@28221|Deltaproteobacteria,2Z2WE@29|Myxococcales	28221|Deltaproteobacteria	T	PAS fold	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HATPase_c,HisKA,PAS,PAS_3,PAS_4,Response_reg
HKD2_k127_1786676_4	1254432.SCE1572_17330	4.451e-66	239.0	COG0631@1|root,COG0631@2|Bacteria,1R7UF@1224|Proteobacteria,42QUA@68525|delta/epsilon subdivisions,2WP2A@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	protein phosphatase 2C domain protein	-	-	3.1.3.16	ko:K01090,ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C,PP2C_2
HKD2_k127_1786676_2	1382356.JQMP01000003_gene1989	4.718e-105	355.0	COG0166@1|root,COG0176@1|root,COG0166@2|Bacteria,COG0176@2|Bacteria,2G67J@200795|Chloroflexi,27XXA@189775|Thermomicrobia	189775|Thermomicrobia	G	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway	tal	-	2.2.1.2,5.3.1.9	ko:K13810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00004,M00007,M00114	R01827,R02739,R02740,R03321	RC00376,RC00439,RC00563,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	PGI,TAL_FSA
HKD2_k127_1786676_6	318996.AXAZ01000037_gene1365	6.189e-09	66.0	COG3637@1|root,COG3637@2|Bacteria,1PW82@1224|Proteobacteria,2U8GW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1786676_0	378806.STAUR_1890	1.378e-185	584.0	COG1274@1|root,COG1274@2|Bacteria,1MX3C@1224|Proteobacteria,42PRT@68525|delta/epsilon subdivisions,2WIWH@28221|Deltaproteobacteria,2YU1K@29|Myxococcales	28221|Deltaproteobacteria	H	Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle	pckG	-	4.1.1.32	ko:K01596	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko03320,ko04068,ko04151,ko04152,ko04910,ko04920,ko04922,ko04931,ko04964,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map03320,map04068,map04151,map04152,map04910,map04920,map04922,map04931,map04964	M00003	R00431,R00726	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2638	PEPCK_C,PEPCK_N
HKD2_k127_179313_4	522373.Smlt1113	3.253e-44	175.0	COG1137@1|root,COG1137@2|Bacteria,1MU8M@1224|Proteobacteria,1RPW1@1236|Gammaproteobacteria,1X31A@135614|Xanthomonadales	135614|Xanthomonadales	S	abc transporter atp-binding protein	lptB	-	-	ko:K06861	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	1.B.42.1	-	-	ABC_tran,BCA_ABC_TP_C
HKD2_k127_179313_8	633131.TR2A62_2521	1.925e-10	71.0	COG1934@1|root,COG1934@2|Bacteria,1MXGA@1224|Proteobacteria,2U6DD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein conserved in bacteria	lptA	-	-	ko:K09774	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	OstA
HKD2_k127_179313_0	448385.sce3622	6.898e-143	483.0	COG0699@1|root,COG0699@2|Bacteria,1NBKR@1224|Proteobacteria,42NDN@68525|delta/epsilon subdivisions	1224|Proteobacteria	S	Dynamin family	-	-	-	-	-	-	-	-	-	-	-	-	Dynamin_N
HKD2_k127_179313_2	448385.sce5256	8.992e-47	186.0	COG1293@1|root,COG1293@2|Bacteria,1R54S@1224|Proteobacteria,42MYG@68525|delta/epsilon subdivisions	1224|Proteobacteria	K	RNA-binding protein homologous to eukaryotic snRNP	-	-	-	-	-	-	-	-	-	-	-	-	DUF814,FbpA
HKD2_k127_179313_1	391625.PPSIR1_10550	5.27e-48	194.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,42Q67@68525|delta/epsilon subdivisions	1224|Proteobacteria	KLT	Serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_12,TPR_8
HKD2_k127_179313_6	272568.GDI0677	3.615e-24	118.0	COG0389@1|root,COG0389@2|Bacteria,1MU5X@1224|Proteobacteria,2TQVR@28211|Alphaproteobacteria,2JR90@204441|Rhodospirillales	204441|Rhodospirillales	L	Nucleotidyltransferase DNA polymerase involved in DNA repair	-	-	-	ko:K14161	-	-	-	-	ko00000,ko03400	-	-	-	IMS
HKD2_k127_179313_5	1192034.CAP_7838	1.363e-25	113.0	COG0468@1|root,COG0468@2|Bacteria,1PBWC@1224|Proteobacteria,433TR@68525|delta/epsilon subdivisions,2X3F6@28221|Deltaproteobacteria,2YVTP@29|Myxococcales	28221|Deltaproteobacteria	L	recA bacterial DNA recombination protein	-	-	-	-	-	-	-	-	-	-	-	-	RecA
HKD2_k127_182350_0	391625.PPSIR1_42044	3.228e-188	614.0	COG0402@1|root,COG2374@1|root,COG3209@1|root,COG0402@2|Bacteria,COG2374@2|Bacteria,COG3209@2|Bacteria,1NFUA@1224|Proteobacteria,433MB@68525|delta/epsilon subdivisions,2WXJF@28221|Deltaproteobacteria,2YUGP@29|Myxococcales	28221|Deltaproteobacteria	F	Lamin Tail Domain	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1,DUF4215,LTD,TSP_3
HKD2_k127_182350_1	379066.GAU_2049	3.111e-76	264.0	COG0730@1|root,COG0730@2|Bacteria,1ZUET@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	response to heat	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_182350_2	1266925.JHVX01000002_gene954	7.278e-44	165.0	COG0500@1|root,COG2226@2|Bacteria,1MW7J@1224|Proteobacteria	1224|Proteobacteria	Q	PFAM O-methyltransferase family 2	crtF	-	2.1.1.210	ko:K09846	ko00906,ko01100,map00906,map01100	-	R07521,R07524,R07527,R07529,R07533,R07535	RC00003,RC02082	ko00000,ko00001,ko01000	-	-	-	Dimerisation2,Methyltransf_2
HKD2_k127_1834476_1	1254432.SCE1572_45855	3.187e-97	328.0	COG0750@1|root,COG0750@2|Bacteria,1MU91@1224|Proteobacteria,42NJ0@68525|delta/epsilon subdivisions,2WJ7A@28221|Deltaproteobacteria,2YV9N@29|Myxococcales	28221|Deltaproteobacteria	M	Peptidase family M50	-	-	-	ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_M50
HKD2_k127_1834476_4	196162.Noca_1660	2.718e-05	55.0	COG0664@1|root,COG0664@2|Bacteria,2IINQ@201174|Actinobacteria	201174|Actinobacteria	K	COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases	-	-	-	ko:K21564	-	-	-	-	ko00000,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
HKD2_k127_1834476_0	1192034.CAP_1775	3.775e-112	386.0	COG4206@1|root,COG4206@2|Bacteria,1MW63@1224|Proteobacteria,43C33@68525|delta/epsilon subdivisions,2X7DR@28221|Deltaproteobacteria,2Z0ZD@29|Myxococcales	28221|Deltaproteobacteria	H	TonB dependent receptor	-	-	-	ko:K02014,ko:K16092	-	-	-	-	ko00000,ko02000	1.B.14,1.B.14.3	-	-	Plug,TonB_dep_Rec
HKD2_k127_1834476_2	1254432.SCE1572_01880	1.325e-72	257.0	COG3509@1|root,COG3509@2|Bacteria,1N6M6@1224|Proteobacteria,42U8Z@68525|delta/epsilon subdivisions,2WQQT@28221|Deltaproteobacteria,2YV47@29|Myxococcales	28221|Deltaproteobacteria	Q	Esterase PHB depolymerase	-	-	-	ko:K03932	-	-	-	-	ko00000	-	CE1	-	Esterase_phd
HKD2_k127_1834476_3	1254432.SCE1572_45515	7.932e-06	53.0	COG0457@1|root,COG0457@2|Bacteria	1254432.SCE1572_45515|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1837318_1	246197.MXAN_5543	5.853e-60	217.0	COG2217@1|root,COG2608@1|root,COG2217@2|Bacteria,COG2608@2|Bacteria,1MU08@1224|Proteobacteria,42M2R@68525|delta/epsilon subdivisions	1224|Proteobacteria	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	fixI	GO:0003674,GO:0003824,GO:0005215,GO:0005388,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006816,GO:0008150,GO:0008324,GO:0015075,GO:0015085,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0031226,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043492,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0070588,GO:0070838,GO:0071944,GO:0072511,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132	3.6.3.4,3.6.3.54	ko:K01533,ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	ATPase-cat_bd,E1-E2_ATPase,HMA,Hydrolase
HKD2_k127_1837318_2	1386089.N865_16840	1.633e-57	205.0	COG3911@1|root,COG3911@2|Bacteria	2|Bacteria	K	COG3911 Predicted ATPase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_28
HKD2_k127_1837318_4	1121861.KB899911_gene1318	8.567e-08	58.0	COG1278@1|root,COG1278@2|Bacteria,1QW5N@1224|Proteobacteria,2U8SB@28211|Alphaproteobacteria,2JYXA@204441|Rhodospirillales	204441|Rhodospirillales	K	Sigma 54 modulation protein / S30EA ribosomal protein	-	-	-	-	-	-	-	-	-	-	-	-	CSD,Ribosomal_S30AE
HKD2_k127_1837318_0	1254432.SCE1572_35745	4.899e-212	669.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2YTW0@29|Myxococcales	28221|Deltaproteobacteria	T	response regulator	-	-	-	ko:K02481,ko:K07713	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD2_k127_1837318_3	448385.sce6012	6.493e-18	83.0	COG3852@1|root,COG3852@2|Bacteria,1R0D4@1224|Proteobacteria,43CVR@68525|delta/epsilon subdivisions,2X83R@28221|Deltaproteobacteria,2Z3K9@29|Myxococcales	28221|Deltaproteobacteria	F	Protoglobin	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Protoglobin
HKD2_k127_1839946_1	909663.KI867150_gene269	8.573e-66	233.0	COG0531@1|root,COG0531@2|Bacteria,1R829@1224|Proteobacteria,42MS5@68525|delta/epsilon subdivisions,2WINQ@28221|Deltaproteobacteria,2MSEM@213462|Syntrophobacterales	28221|Deltaproteobacteria	E	Amino acid permease	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
HKD2_k127_1839946_0	1254432.SCE1572_10845	6.701e-111	372.0	COG3158@1|root,COG3158@2|Bacteria,1MUVH@1224|Proteobacteria,42P5Y@68525|delta/epsilon subdivisions,2WJEH@28221|Deltaproteobacteria,2YXPN@29|Myxococcales	28221|Deltaproteobacteria	P	Transport of potassium into the cell	kup	GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015672,GO:0016020,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0098655,GO:0098660,GO:0098662	-	ko:K03549	-	-	-	-	ko00000,ko02000	2.A.72	-	-	K_trans
HKD2_k127_1855909_1	9544.ENSMMUP00000032251	3.315e-60	220.0	COG0596@1|root,KOG4178@2759|Eukaryota,39VYC@33154|Opisthokonta,3BNBY@33208|Metazoa,3CT56@33213|Bilateria,48GUN@7711|Chordata	33208|Metazoa	I	Alpha/beta hydrolase family	-	-	1.13.12.5	ko:K18053	-	-	-	-	ko00000,ko01000	-	-	-	Abhydrolase_1
HKD2_k127_1855909_2	448385.sce7810	2.377e-26	111.0	COG1733@1|root,COG1733@2|Bacteria,1Q99V@1224|Proteobacteria,43DPJ@68525|delta/epsilon subdivisions,2WZGN@28221|Deltaproteobacteria,2Z241@29|Myxococcales	28221|Deltaproteobacteria	K	HxlR-like helix-turn-helix	-	-	-	-	-	-	-	-	-	-	-	-	HxlR
HKD2_k127_1855909_0	1254432.SCE1572_45620	1.307e-69	249.0	COG0563@1|root,COG0563@2|Bacteria,1MXCZ@1224|Proteobacteria,42M8E@68525|delta/epsilon subdivisions,2WJH0@28221|Deltaproteobacteria,2YV4U@29|Myxococcales	28221|Deltaproteobacteria	F	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism	adk	GO:0003674,GO:0003824,GO:0004017,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901576	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ADK,ADK_lid
HKD2_k127_186418_1	1192034.CAP_5909	8.25e-181	584.0	COG3291@1|root,COG3291@2|Bacteria,1QEIS@1224|Proteobacteria,4389M@68525|delta/epsilon subdivisions,2X3J1@28221|Deltaproteobacteria,2YWAB@29|Myxococcales	28221|Deltaproteobacteria	S	IgGFc binding protein	-	-	-	-	-	-	-	-	-	-	-	-	IgGFc_binding
HKD2_k127_186418_2	448385.sce2590	9.122e-130	444.0	COG1404@1|root,COG1404@2|Bacteria,1PXZ6@1224|Proteobacteria,434YU@68525|delta/epsilon subdivisions,2WZ9R@28221|Deltaproteobacteria,2Z1NG@29|Myxococcales	28221|Deltaproteobacteria	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
HKD2_k127_186418_0	502025.Hoch_2126	6.906e-189	605.0	COG2866@1|root,COG2866@2|Bacteria,1R586@1224|Proteobacteria,433ZT@68525|delta/epsilon subdivisions,2X4AT@28221|Deltaproteobacteria,2YYMP@29|Myxococcales	28221|Deltaproteobacteria	E	Zn_pept	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M14
HKD2_k127_186418_3	1254432.SCE1572_37735	1.374e-125	417.0	COG2010@1|root,COG2010@2|Bacteria,1QX4J@1224|Proteobacteria,43CNY@68525|delta/epsilon subdivisions,2X7W8@28221|Deltaproteobacteria,2YX21@29|Myxococcales	28221|Deltaproteobacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cu2_monoox_C,Cu2_monooxygen
HKD2_k127_186418_5	1151061.CAJY01000017_gene366	5.511e-05	53.0	COG0515@1|root,COG0515@2|Bacteria,2GMPZ@201174|Actinobacteria	201174|Actinobacteria	KLT	serine threonine protein kinase	pknA	GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008360,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0022603,GO:0022604,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0036211,GO:0040007,GO:0042304,GO:0043085,GO:0043086,GO:0043170,GO:0043388,GO:0043412,GO:0044092,GO:0044093,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046777,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0051055,GO:0051098,GO:0051099,GO:0051101,GO:0051128,GO:0062012,GO:0062014,GO:0065007,GO:0065008,GO:0065009,GO:0071704,GO:0071944,GO:0080090,GO:0140096,GO:1901564	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
HKD2_k127_1866690_1	1519464.HY22_13440	6.043e-75	258.0	COG3880@1|root,COG3880@2|Bacteria	2|Bacteria	E	PFAM UvrB UvrC protein	mcsA	GO:0003674,GO:0005488,GO:0005507,GO:0006950,GO:0008150,GO:0008270,GO:0010035,GO:0010038,GO:0042221,GO:0043167,GO:0043169,GO:0046686,GO:0046688,GO:0046870,GO:0046872,GO:0046914,GO:0050896,GO:0050897,GO:0097501,GO:1990169,GO:1990170	2.7.14.1	ko:K19405,ko:K19411	-	-	R11090	RC00002,RC00203	ko00000,ko01000	-	-	-	Cytochrom_CIII,Cytochrome_C7,GSu_C4xC__C2xCH,UVR
HKD2_k127_1866690_0	1192034.CAP_2024	1.063e-85	309.0	COG0243@1|root,COG0437@1|root,COG0243@2|Bacteria,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,42NEG@68525|delta/epsilon subdivisions,2WKHA@28221|Deltaproteobacteria,2YZ1M@29|Myxococcales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	actB	-	-	ko:K00184	-	-	-	-	ko00000	5.A.3	-	-	Fer4_7,Molybdop_Fe4S4,Molybdopterin,Molydop_binding
HKD2_k127_1872584_21	1192034.CAP_4245	1.092e-10	73.0	COG0515@1|root,COG0515@2|Bacteria	1192034.CAP_4245|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1872584_19	1297742.A176_01209	7.4e-17	90.0	COG0543@1|root,COG0543@2|Bacteria,1R6QZ@1224|Proteobacteria,42MVW@68525|delta/epsilon subdivisions,2WNRN@28221|Deltaproteobacteria,2YW8K@29|Myxococcales	28221|Deltaproteobacteria	C	Oxidoreductase NAD-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	DHODB_Fe-S_bind,FAD_binding_6,NAD_binding_1
HKD2_k127_1872584_18	448385.sce2559	2.512e-26	122.0	COG0457@1|root,COG0457@2|Bacteria	448385.sce2559|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1872584_15	1192034.CAP_6721	5.672e-36	142.0	COG2332@1|root,COG2332@2|Bacteria	2|Bacteria	O	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH	ccmE	-	-	ko:K02197	-	-	-	-	ko00000	-	-	-	CcmE
HKD2_k127_1872584_2	448385.sce1711	5.056e-89	296.0	COG1403@1|root,COG1403@2|Bacteria,1MWEQ@1224|Proteobacteria,437B2@68525|delta/epsilon subdivisions,2X2FR@28221|Deltaproteobacteria,2Z0QW@29|Myxococcales	28221|Deltaproteobacteria	L	HNH endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	HNH_5
HKD2_k127_1872584_8	1192034.CAP_7190	2.335e-69	265.0	COG0515@1|root,COG0515@2|Bacteria,1Q35Q@1224|Proteobacteria,438W9@68525|delta/epsilon subdivisions,2X41T@28221|Deltaproteobacteria,2YXZI@29|Myxococcales	28221|Deltaproteobacteria	KLT	Protein kinase domain	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
HKD2_k127_1872584_13	1192034.CAP_8091	4.866e-48	182.0	COG3219@1|root,COG3219@2|Bacteria,1RI5N@1224|Proteobacteria,435AA@68525|delta/epsilon subdivisions,2WZMC@28221|Deltaproteobacteria,2Z2DA@29|Myxococcales	28221|Deltaproteobacteria	S	Putative DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF2063
HKD2_k127_1872584_1	1192034.CAP_8090	3.893e-101	337.0	COG3220@1|root,COG3220@2|Bacteria,1MURE@1224|Proteobacteria,42SA5@68525|delta/epsilon subdivisions,2WNP1@28221|Deltaproteobacteria,2YUAM@29|Myxococcales	28221|Deltaproteobacteria	S	protein conserved in bacteria	-	-	-	ko:K09930	-	-	-	-	ko00000	-	-	-	DUF692
HKD2_k127_1872584_24	1094980.Mpsy_1153	2.176e-05	55.0	COG1378@1|root,arCOG02038@2157|Archaea,2Y7FZ@28890|Euryarchaeota	28890|Euryarchaeota	K	Sugar-specific transcriptional regulator TrmB	-	-	-	-	-	-	-	-	-	-	-	-	Regulator_TrmB,TrmB
HKD2_k127_1872584_0	1254432.SCE1572_10720	2.816e-190	622.0	2BS7F@1|root,32M8R@2|Bacteria,1Q33Y@1224|Proteobacteria,433XP@68525|delta/epsilon subdivisions,2X2HG@28221|Deltaproteobacteria,2YXTX@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1872584_9	448385.sce1706	2.063e-63	228.0	COG1360@1|root,COG1360@2|Bacteria,1PDU8@1224|Proteobacteria,42RAZ@68525|delta/epsilon subdivisions,2WMY4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	N	PFAM OmpA MotB domain protein	-	-	-	ko:K02557	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1	-	-	MotB_plug,OmpA
HKD2_k127_1872584_4	448385.sce1705	1.904e-80	278.0	COG0248@1|root,COG0248@2|Bacteria,1MV35@1224|Proteobacteria,42NIH@68525|delta/epsilon subdivisions,2WQJT@28221|Deltaproteobacteria,2YV3J@29|Myxococcales	28221|Deltaproteobacteria	FP	Ppx GppA	gppA-1	-	3.6.1.11,3.6.1.40	ko:K01524	ko00230,map00230	-	R03409	RC00002	ko00000,ko00001,ko01000	-	-	-	Ppx-GppA
HKD2_k127_1872584_16	1192034.CAP_0776	2.511e-34	148.0	COG1729@1|root,COG1729@2|Bacteria	2|Bacteria	S	protein trimerization	-	-	-	-	-	-	-	-	-	-	-	-	PEGA,TPR_16,TPR_6,TPR_8
HKD2_k127_1872584_5	1192034.CAP_0774	1.427e-75	271.0	COG0515@1|root,COG0515@2|Bacteria	1192034.CAP_0774|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1872584_7	1192034.CAP_7797	2.894e-71	246.0	COG1329@1|root,COG1329@2|Bacteria,1MWI2@1224|Proteobacteria,42RXS@68525|delta/epsilon subdivisions,2WNA0@28221|Deltaproteobacteria,2YVAI@29|Myxococcales	28221|Deltaproteobacteria	K	Transcriptional regulator, CarD family	-	-	-	ko:K07736	-	-	-	-	ko00000,ko03000	-	-	-	CarD_CdnL_TRCF
HKD2_k127_1872584_22	313606.M23134_04602	3.897e-08	64.0	COG4314@1|root,COG4314@2|Bacteria,4P5DT@976|Bacteroidetes,47W2W@768503|Cytophagia	976|Bacteroidetes	C	NosL	-	-	-	-	-	-	-	-	-	-	-	-	NosL
HKD2_k127_1872584_17	1121035.AUCH01000012_gene2915	2.27e-26	121.0	28K4S@1|root,2Z9TM@2|Bacteria,1N4AQ@1224|Proteobacteria,2VK2F@28216|Betaproteobacteria,2KV3C@206389|Rhodocyclales	206389|Rhodocyclales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1872584_14	1121918.ARWE01000001_gene2788	5.759e-48	179.0	COG1136@1|root,COG1136@2|Bacteria,1PFRW@1224|Proteobacteria,42P38@68525|delta/epsilon subdivisions,2WMS9@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	PFAM ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD2_k127_1872584_10	1192034.CAP_5352	4.205e-56	207.0	COG0664@1|root,COG0664@2|Bacteria,1N61M@1224|Proteobacteria,42Y1U@68525|delta/epsilon subdivisions,2WNPK@28221|Deltaproteobacteria,2YVYQ@29|Myxococcales	28221|Deltaproteobacteria	T	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,cNMP_binding
HKD2_k127_1872584_11	448385.sce8188	1.229e-55	209.0	COG0454@1|root,COG0456@2|Bacteria,1PYGZ@1224|Proteobacteria,435DK@68525|delta/epsilon subdivisions,2WZR5@28221|Deltaproteobacteria,2Z2JT@29|Myxococcales	28221|Deltaproteobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HKD2_k127_1872584_3	1121403.AUCV01000005_gene299	6.163e-84	283.0	COG0036@1|root,COG0036@2|Bacteria,1MUZM@1224|Proteobacteria,42NC0@68525|delta/epsilon subdivisions,2WJK9@28221|Deltaproteobacteria,2MHRY@213118|Desulfobacterales	28221|Deltaproteobacteria	G	Belongs to the ribulose-phosphate 3-epimerase family	rpe	-	5.1.3.1	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
HKD2_k127_1872584_12	448385.sce8190	4.549e-49	197.0	COG2856@1|root,COG2856@2|Bacteria,1PADA@1224|Proteobacteria,434WD@68525|delta/epsilon subdivisions,2WZ7C@28221|Deltaproteobacteria,2Z1HG@29|Myxococcales	28221|Deltaproteobacteria	E	Zn peptidase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1872584_6	1254432.SCE1572_23155	9.428e-73	255.0	COG1807@1|root,COG1807@2|Bacteria,1QX93@1224|Proteobacteria,43C25@68525|delta/epsilon subdivisions,2X7CQ@28221|Deltaproteobacteria,2YUUE@29|Myxococcales	28221|Deltaproteobacteria	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HKD2_k127_1900211_10	502025.Hoch_6772	3.665e-07	63.0	COG0457@1|root,COG0484@1|root,COG3266@1|root,COG0457@2|Bacteria,COG0484@2|Bacteria,COG3266@2|Bacteria,1NX2M@1224|Proteobacteria,43BW9@68525|delta/epsilon subdivisions,2WVDY@28221|Deltaproteobacteria,2Z38B@29|Myxococcales	28221|Deltaproteobacteria	O	DnaJ molecular chaperone homology domain	-	-	-	-	-	-	-	-	-	-	-	-	DnaJ,TPR_2
HKD2_k127_1900211_11	1382356.JQMP01000001_gene1024	1.472e-06	61.0	COG1846@1|root,COG1846@2|Bacteria,2GB9V@200795|Chloroflexi,27YED@189775|Thermomicrobia	189775|Thermomicrobia	K	Domain of unknown function (DUF4388)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4388
HKD2_k127_1900211_1	448385.sce2918	5.302e-84	287.0	COG1716@1|root,COG1716@2|Bacteria,1NEW5@1224|Proteobacteria,42VUF@68525|delta/epsilon subdivisions,2WRV9@28221|Deltaproteobacteria,2YV34@29|Myxococcales	28221|Deltaproteobacteria	T	FHA domain	-	-	-	-	-	-	-	-	-	-	-	-	FHA,TonB_C,Yop-YscD_cpl
HKD2_k127_1900211_7	448385.sce0648	4.655e-19	100.0	COG2885@1|root,COG2885@2|Bacteria,1QAG8@1224|Proteobacteria,4352E@68525|delta/epsilon subdivisions,2WZDB@28221|Deltaproteobacteria,2Z1W3@29|Myxococcales	28221|Deltaproteobacteria	M	Belongs to the ompA family	-	-	-	ko:K03640	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	OmpA
HKD2_k127_1900211_8	929556.Solca_1445	3.506e-09	68.0	2ATWF@1|root,31JFP@2|Bacteria,4NQPB@976|Bacteroidetes,1ITBA@117747|Sphingobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1900211_0	1192034.CAP_2844	7.933e-105	355.0	COG0330@1|root,COG0330@2|Bacteria,1Q1RS@1224|Proteobacteria,437F1@68525|delta/epsilon subdivisions,2X2MG@28221|Deltaproteobacteria,2YTT6@29|Myxococcales	28221|Deltaproteobacteria	O	prohibitin homologues	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
HKD2_k127_1900211_2	1254432.SCE1572_11630	3.015e-61	222.0	arCOG10456@1|root,2ZA6T@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1900211_5	448385.sce0648	3.532e-22	109.0	COG2885@1|root,COG2885@2|Bacteria,1QAG8@1224|Proteobacteria,4352E@68525|delta/epsilon subdivisions,2WZDB@28221|Deltaproteobacteria,2Z1W3@29|Myxococcales	28221|Deltaproteobacteria	M	Belongs to the ompA family	-	-	-	ko:K03640	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	OmpA
HKD2_k127_1900211_9	1089547.KB913013_gene1601	7.61e-09	63.0	COG0845@1|root,COG0845@2|Bacteria,4NI7Q@976|Bacteroidetes,47JYK@768503|Cytophagia	976|Bacteroidetes	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1900730_5	1270193.JARP01000002_gene658	2.525e-05	55.0	COG4313@1|root,COG4313@2|Bacteria,4NW4N@976|Bacteroidetes,1I60R@117743|Flavobacteriia,2NVHT@237|Flavobacterium	976|Bacteroidetes	C	Putative MetA-pathway of phenol degradation	-	-	-	-	-	-	-	-	-	-	-	-	Phenol_MetA_deg
HKD2_k127_1900730_4	768704.Desmer_2846	7.075e-29	120.0	arCOG05253@1|root,30YM0@2|Bacteria,1U8SS@1239|Firmicutes,25HXR@186801|Clostridia,265WF@186807|Peptococcaceae	186801|Clostridia	S	YmaF family	-	-	-	-	-	-	-	-	-	-	-	-	YmaF
HKD2_k127_1900730_3	1458357.BG58_15235	4.52e-37	157.0	COG2326@1|root,COG2326@2|Bacteria,1MVE2@1224|Proteobacteria,2VGZV@28216|Betaproteobacteria,1K04Y@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Polyphosphate kinase 2 (PPK2)	ppk2	-	2.7.4.1	ko:K22468	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PPK2
HKD2_k127_1900730_0	1123242.JH636434_gene5275	8.419e-213	677.0	COG4320@1|root,COG4320@2|Bacteria	2|Bacteria	S	Uncharacterized protein conserved in bacteria (DUF2252)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2252
HKD2_k127_1900730_1	1123242.JH636434_gene5274	1.056e-116	388.0	28M5B@1|root,2ZAJ4@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1900730_2	1134912.AJTV01000038_gene3330	3.153e-93	314.0	COG3459@1|root,COG3459@2|Bacteria,1MVNX@1224|Proteobacteria,2TSAJ@28211|Alphaproteobacteria,36Y2W@31993|Methylocystaceae	28211|Alphaproteobacteria	G	Glycosyl hydrolase 36 superfamily, catalytic domain	ndvB	GO:0003674,GO:0003824,GO:0016740,GO:0016757	2.4.1.321	ko:K13688,ko:K18786	-	-	R10832	RC00397	ko00000,ko01000,ko01003	-	GH94,GT84	-	Glyco_hydro_36,Glyco_transf_36,Glycoamylase
HKD2_k127_1928561_4	1192034.CAP_2829	1.388e-38	164.0	COG0419@1|root,COG4717@1|root,COG0419@2|Bacteria,COG4717@2|Bacteria,1MVAW@1224|Proteobacteria,42MYC@68525|delta/epsilon subdivisions,2WJXA@28221|Deltaproteobacteria,2Z2A3@29|Myxococcales	28221|Deltaproteobacteria	L	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_27
HKD2_k127_1928561_1	448385.sce7166	5.13e-127	421.0	COG0420@1|root,COG0420@2|Bacteria,1MXMJ@1224|Proteobacteria,42Q5U@68525|delta/epsilon subdivisions,2WINF@28221|Deltaproteobacteria,2Z0R7@29|Myxococcales	28221|Deltaproteobacteria	L	Calcineurin-like phosphoesterase superfamily domain	sbcD-1	-	-	ko:K03547	-	-	-	-	ko00000,ko03400	-	-	-	Metallophos,Metallophos_2
HKD2_k127_1928561_0	215803.DB30_4404	2.515e-159	517.0	COG0765@1|root,COG0834@1|root,COG0765@2|Bacteria,COG0834@2|Bacteria,1MWF0@1224|Proteobacteria,42PF3@68525|delta/epsilon subdivisions,2X5DP@28221|Deltaproteobacteria,2YXPR@29|Myxococcales	28221|Deltaproteobacteria	P	Bacterial periplasmic substrate-binding proteins	-	-	-	ko:K02029,ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	BPD_transp_1,SBP_bac_3
HKD2_k127_1928561_3	1532557.JL37_06300	1.335e-59	214.0	COG1126@1|root,COG1126@2|Bacteria,1MU9Q@1224|Proteobacteria,2VN10@28216|Betaproteobacteria,3T1FZ@506|Alcaligenaceae	28216|Betaproteobacteria	E	to ATP-binding component of ABC transporters	glnQ	-	-	ko:K10038	ko02010,map02010	M00227	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.3.2	-	-	ABC_tran
HKD2_k127_1928561_2	234267.Acid_5901	3.389e-119	385.0	COG0450@1|root,COG0450@2|Bacteria,3Y444@57723|Acidobacteria	57723|Acidobacteria	O	PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	-	-	-	-	-	-	-	-	-	-	-	-	1-cysPrx_C,AhpC-TSA
HKD2_k127_1928561_5	1254432.SCE1572_12360	0.00027	48.0	COG0760@1|root,COG0760@2|Bacteria	2|Bacteria	O	peptidyl-prolyl cis-trans isomerase activity	ppiD	-	5.2.1.8	ko:K03769,ko:K03770,ko:K07533	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_3
HKD2_k127_1936400_2	448385.sce7541	2.068e-35	139.0	COG1842@1|root,COG1842@2|Bacteria	2|Bacteria	KT	Phage shock protein A	pspA	-	-	ko:K03969	-	-	-	-	ko00000	-	-	-	PspA_IM30
HKD2_k127_1936400_3	448385.sce3049	3.506e-30	136.0	COG1633@1|root,COG1633@2|Bacteria,1QA00@1224|Proteobacteria,434PZ@68525|delta/epsilon subdivisions,2X8YV@28221|Deltaproteobacteria,2Z13N@29|Myxococcales	28221|Deltaproteobacteria	S	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1936400_1	215803.DB30_3695	1.15e-42	178.0	COG1377@1|root,COG1377@2|Bacteria,1MUWI@1224|Proteobacteria,42NKR@68525|delta/epsilon subdivisions,2WJIQ@28221|Deltaproteobacteria,2YYX9@29|Myxococcales	28221|Deltaproteobacteria	NU	FlhB HrpN YscU SpaS Family	flhB	-	-	ko:K02401	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	Bac_export_2
HKD2_k127_1936400_0	632292.Calhy_1613	9.293e-110	364.0	COG0536@1|root,COG0536@2|Bacteria,1TPX7@1239|Firmicutes,247SP@186801|Clostridia,42F3Z@68295|Thermoanaerobacterales	186801|Clostridia	S	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control	obg	-	-	ko:K03979	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	DUF1967,GTP1_OBG,MMR_HSR1
HKD2_k127_1936400_5	502025.Hoch_1392	5.072e-15	87.0	COG3055@1|root,COG3055@2|Bacteria,1R0N3@1224|Proteobacteria	1224|Proteobacteria	D	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1941979_2	1192034.CAP_5023	3.721e-46	192.0	COG0457@1|root,COG0457@2|Bacteria,1PXR4@1224|Proteobacteria,43DWZ@68525|delta/epsilon subdivisions,2WZ3E@28221|Deltaproteobacteria,2Z18R@29|Myxococcales	28221|Deltaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1941979_0	1192034.CAP_5024	0.0	1052.0	COG0457@1|root,COG0457@2|Bacteria,1QA96@1224|Proteobacteria,43DYT@68525|delta/epsilon subdivisions,2X92B@28221|Deltaproteobacteria,2Z1IW@29|Myxococcales	28221|Deltaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1941979_5	448385.sce4445	7.072e-30	132.0	COG0355@1|root,COG0355@2|Bacteria,1RHE4@1224|Proteobacteria,42TII@68525|delta/epsilon subdivisions,2WPVK@28221|Deltaproteobacteria,2YW5U@29|Myxococcales	28221|Deltaproteobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpC	GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016469,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0045259,GO:0045261,GO:0046034,GO:0046390,GO:0046483,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02114	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_DE,ATP-synt_DE_N
HKD2_k127_1941979_1	574087.Acear_2216	7.112e-85	284.0	COG0055@1|root,COG0055@2|Bacteria,1TPGF@1239|Firmicutes,2489W@186801|Clostridia,3WADA@53433|Halanaerobiales	186801|Clostridia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits	atpD	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_N
HKD2_k127_1946543_0	502025.Hoch_0127	4.467e-125	407.0	COG0444@1|root,COG0444@2|Bacteria,1R4KB@1224|Proteobacteria,42M3F@68525|delta/epsilon subdivisions,2WJ32@28221|Deltaproteobacteria,2YTUG@29|Myxococcales	28221|Deltaproteobacteria	P	Belongs to the ABC transporter superfamily	oppD	-	-	ko:K02031,ko:K12371,ko:K15583	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00324,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
HKD2_k127_1946543_2	288000.BBta_6951	5.224e-117	402.0	COG4608@1|root,COG4608@2|Bacteria,1NU4K@1224|Proteobacteria,2TQTV@28211|Alphaproteobacteria,3JRYC@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Belongs to the ABC transporter superfamily	MA20_20675	-	-	ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
HKD2_k127_1946543_3	1254432.SCE1572_22845	1.798e-77	272.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,42Q67@68525|delta/epsilon subdivisions,2WKZ1@28221|Deltaproteobacteria	28221|Deltaproteobacteria	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_8
HKD2_k127_1946543_4	1565314.OA34_09500	1.383e-42	177.0	COG0790@1|root,COG0790@2|Bacteria,1MWPA@1224|Proteobacteria,42M5H@68525|delta/epsilon subdivisions,2YMZE@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	S	Pfam matches to PF08238.7 Sel1, and to PF08238.7 Sel1, and to PF08238.7 Sel1, and to PF08238.7 Sel1	-	-	-	ko:K07126	-	-	-	-	ko00000	-	-	-	Sel1
HKD2_k127_1946543_5	44689.DDB0231275	1.886e-16	89.0	2CJC4@1|root,2RCK0@2759|Eukaryota,3XB2M@554915|Amoebozoa	554915|Amoebozoa	G	Has antibacterial activity	-	GO:0000270,GO:0003674,GO:0003796,GO:0003824,GO:0004553,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006022,GO:0006026,GO:0006027,GO:0006807,GO:0006810,GO:0006897,GO:0006909,GO:0006950,GO:0006952,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009253,GO:0009605,GO:0009607,GO:0009617,GO:0016192,GO:0016787,GO:0016798,GO:0030203,GO:0031410,GO:0031974,GO:0031982,GO:0031983,GO:0042742,GO:0043170,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043233,GO:0044422,GO:0044424,GO:0044444,GO:0044464,GO:0050830,GO:0050896,GO:0051179,GO:0051234,GO:0051704,GO:0051707,GO:0061783,GO:0071704,GO:0097708,GO:0098542,GO:0098657,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1946543_1	1254432.SCE1572_18155	4.803e-120	410.0	COG1858@1|root,COG3391@1|root,COG1858@2|Bacteria,COG3391@2|Bacteria,1PCDK@1224|Proteobacteria,438DK@68525|delta/epsilon subdivisions,2X3NQ@28221|Deltaproteobacteria,2YWPI@29|Myxococcales	28221|Deltaproteobacteria	C	cytochrome C peroxidase	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C
HKD2_k127_1946829_0	448385.sce6911	1.629e-134	443.0	COG0010@1|root,COG0010@2|Bacteria,1Q4HC@1224|Proteobacteria,42Z7A@68525|delta/epsilon subdivisions,2WU9B@28221|Deltaproteobacteria,2YUSB@29|Myxococcales	28221|Deltaproteobacteria	E	Belongs to the arginase family	-	-	3.5.3.11	ko:K01480	ko00330,ko01100,map00330,map01100	M00133	R01157	RC00024,RC00329	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
HKD2_k127_1946829_2	1210884.HG799468_gene13789	9.531e-26	124.0	COG0501@1|root,COG0501@2|Bacteria	2|Bacteria	O	metalloendopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
HKD2_k127_1946829_3	1254432.SCE1572_35465	2.035e-21	94.0	COG1451@1|root,COG1451@2|Bacteria,1P1X1@1224|Proteobacteria,4314C@68525|delta/epsilon subdivisions,2X3BB@28221|Deltaproteobacteria,2YV83@29|Myxococcales	28221|Deltaproteobacteria	S	nucleotide metabolic process	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1951279_3	468059.AUHA01000003_gene1874	1.376e-95	323.0	COG3000@1|root,COG3000@2|Bacteria,4NFWX@976|Bacteroidetes,1IPCD@117747|Sphingobacteriia	976|Bacteroidetes	I	PFAM Fatty acid hydroxylase	-	-	-	-	-	-	-	-	-	-	-	-	FA_hydroxylase
HKD2_k127_1951279_4	502025.Hoch_1698	3.847e-55	207.0	COG2267@1|root,COG2267@2|Bacteria,1MWF5@1224|Proteobacteria,42T8M@68525|delta/epsilon subdivisions,2WPBS@28221|Deltaproteobacteria,2Z1ZD@29|Myxococcales	28221|Deltaproteobacteria	I	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4
HKD2_k127_1951279_7	264732.Moth_0358	0.0004584	47.0	COG0358@1|root,COG0358@2|Bacteria,1UYVG@1239|Firmicutes,24GCV@186801|Clostridia,42G8Y@68295|Thermoanaerobacterales	186801|Clostridia	L	Domain of unknown function (DUF3854)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3854,zf-CHC2
HKD2_k127_1951279_0	886293.Sinac_1249	0.0	2315.0	COG3459@1|root,COG3459@2|Bacteria,2IYJ0@203682|Planctomycetes	203682|Planctomycetes	G	Putative glucoamylase	-	-	-	ko:K13688	-	-	-	-	ko00000,ko01000,ko01003	-	GH94,GT84	-	Glyco_hydro_36,Glyco_transf_36,Glycoamylase
HKD2_k127_1951279_2	1192034.CAP_7853	6.643e-127	417.0	COG0667@1|root,COG0667@2|Bacteria,1R77F@1224|Proteobacteria,42Y4Z@68525|delta/epsilon subdivisions,2WTTZ@28221|Deltaproteobacteria,2YYIM@29|Myxococcales	28221|Deltaproteobacteria	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
HKD2_k127_1951279_8	109760.SPPG_03665T0	0.0009819	49.0	COG0412@1|root,KOG3043@2759|Eukaryota,3A7FU@33154|Opisthokonta	33154|Opisthokonta	Q	Dienelactone hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	DLH
HKD2_k127_1951279_5	1382359.JIAL01000001_gene2644	7.551e-41	160.0	COG0412@1|root,COG0412@2|Bacteria,3Y4P0@57723|Acidobacteria,2JJCI@204432|Acidobacteriia	204432|Acidobacteriia	Q	Dienelactone hydrolase family	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
HKD2_k127_1951279_1	404589.Anae109_2830	2.735e-169	548.0	COG3285@1|root,COG3285@2|Bacteria,1MVWY@1224|Proteobacteria,430G4@68525|delta/epsilon subdivisions,2WVMP@28221|Deltaproteobacteria,2YZCC@29|Myxococcales	28221|Deltaproteobacteria	L	PFAM DNA primase small subunit	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_200066_1	448385.sce3962	3.555e-47	176.0	COG0515@1|root,COG0515@2|Bacteria	448385.sce3962|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_200066_0	1254432.SCE1572_21860	3.691e-90	310.0	COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,42Q0K@68525|delta/epsilon subdivisions,2WJUW@28221|Deltaproteobacteria,2YTVH@29|Myxococcales	28221|Deltaproteobacteria	L	DbpA RNA binding domain	dedA	-	3.6.4.13	ko:K03732,ko:K05592	ko03018,map03018	M00394	-	-	ko00000,ko00001,ko00002,ko01000,ko03009,ko03019	-	-	-	DEAD,DbpA,Helicase_C
HKD2_k127_200730_11	56780.SYN_00708	8.019e-13	68.0	COG1837@1|root,COG1837@2|Bacteria	2|Bacteria	L	Belongs to the UPF0109 family	CP_0026	-	-	ko:K06960	-	-	-	-	ko00000	-	-	-	KH_4
HKD2_k127_200730_7	448385.sce4437	1.56e-42	162.0	COG0806@1|root,COG0806@2|Bacteria,1MWQR@1224|Proteobacteria,42TGI@68525|delta/epsilon subdivisions,2WQJU@28221|Deltaproteobacteria,2YW17@29|Myxococcales	28221|Deltaproteobacteria	J	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes	rimM	-	-	ko:K02860	-	-	-	-	ko00000,ko03009	-	-	-	PRC,RimM
HKD2_k127_200730_2	448385.sce4436	3.168e-96	321.0	COG0336@1|root,COG0336@2|Bacteria,1MUN1@1224|Proteobacteria,42P8R@68525|delta/epsilon subdivisions,2WKIR@28221|Deltaproteobacteria,2YV3E@29|Myxococcales	28221|Deltaproteobacteria	J	Belongs to the RNA methyltransferase TrmD family	trmD	GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050518,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.1.1.228	ko:K00554	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	Methyltrn_RNA_4,tRNA_m1G_MT
HKD2_k127_200730_5	1192034.CAP_3421	1.925e-49	192.0	COG4752@1|root,COG4752@2|Bacteria,1RJ2G@1224|Proteobacteria,42SXX@68525|delta/epsilon subdivisions,2WP1I@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	SAM-dependent RNA methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltrn_RNA_4
HKD2_k127_200730_12	502025.Hoch_3788	7.812e-09	67.0	COG0457@1|root,COG0457@2|Bacteria,1PXED@1224|Proteobacteria,434H8@68525|delta/epsilon subdivisions,2WYUK@28221|Deltaproteobacteria,2Z0NH@29|Myxococcales	28221|Deltaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_200730_3	448385.sce4512	6.473e-84	307.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,42MVV@68525|delta/epsilon subdivisions,2X4JB@28221|Deltaproteobacteria,2YZ4I@29|Myxococcales	28221|Deltaproteobacteria	KLT	Family membership	-	-	2.7.11.1	ko:K08884	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HKD2_k127_200730_13	1192034.CAP_7876	9.232e-08	64.0	COG3391@1|root,COG3391@2|Bacteria,1Q2JN@1224|Proteobacteria,4386H@68525|delta/epsilon subdivisions,2X9ZH@28221|Deltaproteobacteria,2YVZH@29|Myxococcales	28221|Deltaproteobacteria	S	Beta-L-arabinofuranosidase, GH127	-	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3
HKD2_k127_200730_8	1280948.HY36_00780	2.769e-31	131.0	COG1309@1|root,COG1309@2|Bacteria,1MUUY@1224|Proteobacteria,2TQY0@28211|Alphaproteobacteria,43ZSS@69657|Hyphomonadaceae	28211|Alphaproteobacteria	K	WHG domain	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N,WHG
HKD2_k127_200730_9	1121439.dsat_2193	1.289e-26	118.0	COG4123@1|root,COG4123@2|Bacteria,1RDSC@1224|Proteobacteria,42RIN@68525|delta/epsilon subdivisions,2WNY8@28221|Deltaproteobacteria,2MBIX@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	PFAM methyltransferase small	-	-	2.1.1.223	ko:K15460	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	MTS,Methyltransf_31
HKD2_k127_200730_1	1192034.CAP_3422	8.056e-108	360.0	COG1600@1|root,COG1600@2|Bacteria,1MV1H@1224|Proteobacteria,42PNR@68525|delta/epsilon subdivisions,2WK3I@28221|Deltaproteobacteria,2YV9T@29|Myxococcales	28221|Deltaproteobacteria	C	Domain of unknown function (DUF1730)	yjeS	-	1.17.99.6	ko:K18979	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DUF1730,Fer4_16,HEAT_2
HKD2_k127_200730_10	545694.TREPR_2623	5.812e-15	89.0	COG0457@1|root,COG0457@2|Bacteria,2J5NB@203691|Spirochaetes	203691|Spirochaetes	S	tetratricopeptide repeat	lmp1	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_11,TPR_16,TPR_2,TPR_6,TPR_7,TPR_8
HKD2_k127_200730_0	448385.sce3917	2.569e-124	417.0	COG1703@1|root,COG1703@2|Bacteria,1MVI0@1224|Proteobacteria,42NBN@68525|delta/epsilon subdivisions,2WK8A@28221|Deltaproteobacteria,2YU28@29|Myxococcales	28221|Deltaproteobacteria	E	ArgK protein	-	-	-	ko:K07588	-	-	-	-	ko00000,ko01000	-	-	-	ArgK
HKD2_k127_200730_4	1192034.CAP_5378	3.047e-67	248.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,42Q67@68525|delta/epsilon subdivisions,2WKZ1@28221|Deltaproteobacteria	1224|Proteobacteria	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HKD2_k127_200730_6	485918.Cpin_5494	6.296e-47	170.0	COG0166@1|root,COG0166@2|Bacteria,4NDV0@976|Bacteroidetes,1IPXI@117747|Sphingobacteriia	976|Bacteroidetes	G	Belongs to the GPI family	pgi	-	5.3.1.9	ko:K01810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114	R02739,R02740,R03321	RC00376,RC00563	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGI
HKD2_k127_20182_0	448385.sce0033	1.404e-193	611.0	COG1508@1|root,COG1508@2|Bacteria,1MW4V@1224|Proteobacteria,42M3C@68525|delta/epsilon subdivisions,2WJ21@28221|Deltaproteobacteria,2YTW6@29|Myxococcales	28221|Deltaproteobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	rpoN	-	-	ko:K03092	ko02020,ko05111,map02020,map05111	-	-	-	ko00000,ko00001,ko03021	-	-	-	Sigma54_AID,Sigma54_CBD,Sigma54_DBD
HKD2_k127_20182_1	448385.sce5769	2.015e-21	98.0	COG1544@1|root,COG1544@2|Bacteria,1MZHW@1224|Proteobacteria,42SJW@68525|delta/epsilon subdivisions,2WPF7@28221|Deltaproteobacteria,2YVRH@29|Myxococcales	28221|Deltaproteobacteria	J	Sigma 54 modulation protein / S30EA ribosomal protein	hpf	-	-	ko:K05808	-	-	-	-	ko00000,ko03009	-	-	-	Ribosom_S30AE_C,Ribosomal_S30AE
HKD2_k127_2059888_1	1254432.SCE1572_38495	1.397e-65	244.0	2DQMB@1|root,337KD@2|Bacteria,1NKJH@1224|Proteobacteria,42X0X@68525|delta/epsilon subdivisions,2WSJT@28221|Deltaproteobacteria,2YVNT@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2059888_0	1254432.SCE1572_38490	1.268e-119	392.0	COG1721@1|root,COG1721@2|Bacteria,1Q7RR@1224|Proteobacteria,42PJB@68525|delta/epsilon subdivisions,2WK1X@28221|Deltaproteobacteria,2YURN@29|Myxococcales	28221|Deltaproteobacteria	S	conserved protein (some members contain a von Willebrand factor type A (vWA) domain)	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
HKD2_k127_2059888_2	716928.AJQT01000039_gene1475	1.787e-15	83.0	COG4119@1|root,COG4119@2|Bacteria,1RHCE@1224|Proteobacteria,2U8N1@28211|Alphaproteobacteria,4BFV9@82115|Rhizobiaceae	28211|Alphaproteobacteria	L	NUDIX hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
HKD2_k127_2062305_2	1254432.SCE1572_10070	1.21e-31	143.0	2AH4I@1|root,317E5@2|Bacteria,1PYQB@1224|Proteobacteria,435HF@68525|delta/epsilon subdivisions,2X99V@28221|Deltaproteobacteria,2Z2T7@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2062305_3	1343740.M271_17615	4.944e-29	134.0	COG0346@1|root,COG0346@2|Bacteria,2IKKR@201174|Actinobacteria	201174|Actinobacteria	E	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HKD2_k127_2062305_0	1194972.MVAC_21003	4.673e-86	293.0	COG3315@1|root,COG3315@2|Bacteria,2GNGD@201174|Actinobacteria,234ZU@1762|Mycobacteriaceae	201174|Actinobacteria	H	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	LCM
HKD2_k127_2062305_6	1220534.B655_1034	0.0002463	52.0	COG1032@1|root,arCOG01356@2157|Archaea	2157|Archaea	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
HKD2_k127_206749_11	1304284.L21TH_1613	2.766e-21	107.0	COG0798@1|root,COG0798@2|Bacteria,1UPMS@1239|Firmicutes,25HJB@186801|Clostridia,36JSK@31979|Clostridiaceae	186801|Clostridia	P	Sodium Bile acid symporter family	-	-	-	-	-	-	-	-	-	-	-	-	SBF
HKD2_k127_206749_10	580331.Thit_1668	1.415e-35	144.0	COG4887@1|root,COG4887@2|Bacteria,1V4ZU@1239|Firmicutes,24CCD@186801|Clostridia,42GVP@68295|Thermoanaerobacterales	186801|Clostridia	S	Protein of unknown function (DUF1847)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1847
HKD2_k127_206749_14	75379.Tint_2605	6.513e-13	76.0	COG3453@1|root,COG3453@2|Bacteria,1RHZ3@1224|Proteobacteria,2W397@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Putative phosphatase (DUF442)	-	-	-	-	-	-	-	-	-	-	-	-	DUF442
HKD2_k127_206749_13	573413.Spirs_3569	2.835e-14	79.0	COG0526@1|root,COG0526@2|Bacteria	2|Bacteria	CO	cell redox homeostasis	bta	-	1.8.1.8	ko:K03671,ko:K03672	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko01000,ko03110	-	-	-	Thioredoxin,TraF
HKD2_k127_206749_3	75379.Tint_1443	1.043e-122	402.0	COG4106@1|root,COG4106@2|Bacteria,1QVHH@1224|Proteobacteria,2WGRG@28216|Betaproteobacteria,1KP8M@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	O-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
HKD2_k127_206749_4	631362.Thi970DRAFT_04936	3.622e-84	288.0	COG0121@1|root,COG0121@2|Bacteria,1MU1J@1224|Proteobacteria,1RNEK@1236|Gammaproteobacteria,1WY4N@135613|Chromatiales	135613|Chromatiales	S	PFAM Glutamine	-	-	-	-	-	-	-	-	-	-	-	-	GATase_4
HKD2_k127_206749_8	138119.DSY3501	5.179e-63	230.0	COG0523@1|root,COG0523@2|Bacteria,1UKHE@1239|Firmicutes,24DT4@186801|Clostridia	186801|Clostridia	S	CobW/HypB/UreG, nucleotide-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	cobW
HKD2_k127_206749_6	1307761.L21SP2_2452	2.788e-71	249.0	COG0500@1|root,COG2226@2|Bacteria,2J6Y1@203691|Spirochaetes	203691|Spirochaetes	Q	Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)	-	-	2.1.1.137	ko:K07755	-	-	-	-	ko00000,ko01000	-	-	-	Methyltransf_31
HKD2_k127_206749_1	1307761.L21SP2_2450	8.502e-152	494.0	COG0641@1|root,COG0641@2|Bacteria,2JB1P@203691|Spirochaetes	203691|Spirochaetes	C	4Fe-4S single cluster domain	-	-	-	ko:K06871	-	-	-	-	ko00000	-	-	-	Fer4_12
HKD2_k127_206749_0	1307761.L21SP2_2449	1.191e-156	505.0	COG0492@1|root,COG0492@2|Bacteria,2J7WA@203691|Spirochaetes	203691|Spirochaetes	C	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
HKD2_k127_206749_2	1192034.CAP_1542	3.687e-150	500.0	COG1297@1|root,COG1297@2|Bacteria,1N7SK@1224|Proteobacteria,42PMM@68525|delta/epsilon subdivisions,2X37C@28221|Deltaproteobacteria,2YUQZ@29|Myxococcales	28221|Deltaproteobacteria	S	OPT oligopeptide transporter protein	-	-	-	-	-	-	-	-	-	-	-	-	OPT
HKD2_k127_206749_12	1480694.DC28_06905	3.447e-15	89.0	COG0308@1|root,COG0308@2|Bacteria,2J7TI@203691|Spirochaetes	203691|Spirochaetes	E	aminopeptidase N	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_206749_7	502025.Hoch_3850	5.198e-65	235.0	COG2133@1|root,COG2133@2|Bacteria,1PEHH@1224|Proteobacteria,437W5@68525|delta/epsilon subdivisions,2X35P@28221|Deltaproteobacteria,2YUDG@29|Myxococcales	28221|Deltaproteobacteria	G	pyrroloquinoline quinone binding	-	-	-	-	-	-	-	-	-	-	-	-	GSDH
HKD2_k127_206749_9	1095769.CAHF01000022_gene157	3.953e-53	202.0	COG3391@1|root,COG3391@2|Bacteria,1R736@1224|Proteobacteria,2W0J3@28216|Betaproteobacteria	28216|Betaproteobacteria	S	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_206749_5	670307.HYPDE_33328	3.416e-77	269.0	COG1388@1|root,COG1388@2|Bacteria,1MY1S@1224|Proteobacteria,2TVJ0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Domain of Unknown Function (DUF1259)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1529
HKD2_k127_207578_0	1254432.SCE1572_35730	3.112e-150	501.0	COG3852@1|root,COG3852@2|Bacteria,1R0D4@1224|Proteobacteria,43CVR@68525|delta/epsilon subdivisions,2X83R@28221|Deltaproteobacteria,2Z3K9@29|Myxococcales	28221|Deltaproteobacteria	F	Protoglobin	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Protoglobin
HKD2_k127_207578_1	1254432.SCE1572_35735	3.014e-35	139.0	COG0784@1|root,COG0784@2|Bacteria	2|Bacteria	T	Response regulator, receiver	-	-	-	ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	Response_reg
HKD2_k127_207578_2	448385.sce7389	1.359e-34	138.0	COG0589@1|root,COG0589@2|Bacteria	2|Bacteria	T	AMP binding	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD2_k127_2076278_1	1144275.COCOR_01086	7.118e-75	270.0	COG3852@1|root,COG3852@2|Bacteria,1QVPN@1224|Proteobacteria	1224|Proteobacteria	T	Histidine kinase	pilS	-	2.7.13.3	ko:K02668	ko02020,map02020	M00501	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	HATPase_c,HisKA,HisKA_7TM,PAS_4,PAS_8
HKD2_k127_2076278_0	215803.DB30_4636	4.713e-128	424.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2YZTT@29|Myxococcales	28221|Deltaproteobacteria	T	Bacterial regulatory protein, Fis family	frgC	-	-	ko:K07714	ko02020,map02020	M00500	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD2_k127_2076278_3	1201290.M902_1265	4.286e-07	57.0	COG0582@1|root,COG0582@2|Bacteria,1QY2G@1224|Proteobacteria,42ZYU@68525|delta/epsilon subdivisions,2MU0Z@213481|Bdellovibrionales,2WVI6@28221|Deltaproteobacteria	213481|Bdellovibrionales	L	Phage integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
HKD2_k127_2076278_2	378806.STAUR_6087	1.674e-22	100.0	COG4974@1|root,COG4974@2|Bacteria,1Q4H1@1224|Proteobacteria,43A00@68525|delta/epsilon subdivisions,2X29E@28221|Deltaproteobacteria,2YZ6M@29|Myxococcales	28221|Deltaproteobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_3,Phage_integrase
HKD2_k127_208909_0	448385.sce5008	6.352e-138	445.0	COG0274@1|root,COG0274@2|Bacteria,1N8AG@1224|Proteobacteria,42S16@68525|delta/epsilon subdivisions,2WNEY@28221|Deltaproteobacteria,2YYRJ@29|Myxococcales	28221|Deltaproteobacteria	H	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate	deoC	-	4.1.2.4	ko:K01619	ko00030,map00030	-	R01066	RC00436,RC00437	ko00000,ko00001,ko01000	-	-	-	DeoC
HKD2_k127_208909_2	448385.sce5360	6.173e-13	79.0	COG1716@1|root,COG2304@1|root,COG4676@1|root,COG4783@1|root,COG1716@2|Bacteria,COG2304@2|Bacteria,COG4676@2|Bacteria,COG4783@2|Bacteria,1PCRX@1224|Proteobacteria,433WB@68525|delta/epsilon subdivisions,2X9AU@28221|Deltaproteobacteria,2YX4K@29|Myxococcales	28221|Deltaproteobacteria	E	Vault protein inter-alpha-trypsin domain	-	-	-	-	-	-	-	-	-	-	-	-	VIT
HKD2_k127_208909_1	1254432.SCE1572_10925	4.682e-26	108.0	COG0828@1|root,COG0828@2|Bacteria,1PDBN@1224|Proteobacteria,435FI@68525|delta/epsilon subdivisions,2WZT4@28221|Deltaproteobacteria,2Z2PN@29|Myxococcales	28221|Deltaproteobacteria	J	Belongs to the bacterial ribosomal protein bS21 family	rpsU	-	-	ko:K02970	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S21
HKD2_k127_2099468_1	1192034.CAP_8689	9.005e-51	199.0	COG0515@1|root,COG0515@2|Bacteria	1192034.CAP_8689|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2099468_0	1297742.A176_05569	2.543e-70	265.0	COG0642@1|root,COG2205@2|Bacteria,1NW75@1224|Proteobacteria	1224|Proteobacteria	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	2.7.13.3	ko:K07709	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	GAF_2,HATPase_c,HisKA,PAS_8
HKD2_k127_2101540_2	391625.PPSIR1_12553	4.239e-84	280.0	COG0388@1|root,COG0388@2|Bacteria,1MXG5@1224|Proteobacteria,42M1Y@68525|delta/epsilon subdivisions,2WP4Z@28221|Deltaproteobacteria,2YU7V@29|Myxococcales	28221|Deltaproteobacteria	S	Carbon-nitrogen hydrolase	-	-	3.5.1.53,3.5.1.6	ko:K01431,ko:K12251	ko00240,ko00330,ko00410,ko00770,ko00983,ko01100,map00240,map00330,map00410,map00770,map00983,map01100	M00046	R00905,R01152,R04666,R08228	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase
HKD2_k127_2101540_1	391625.PPSIR1_12548	8.437e-264	825.0	COG0044@1|root,COG0044@2|Bacteria,1MW10@1224|Proteobacteria,42PXH@68525|delta/epsilon subdivisions,2WKEX@28221|Deltaproteobacteria,2YTWX@29|Myxococcales	28221|Deltaproteobacteria	F	Amidohydrolase family	-	-	3.5.2.2	ko:K01464	ko00240,ko00410,ko00770,ko00983,ko01100,map00240,map00410,map00770,map00983,map01100	M00046	R02269,R03055,R08227	RC00632,RC00680	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Amidohydro_1
HKD2_k127_2101540_0	338969.Rfer_0372	2.202e-279	863.0	COG1012@1|root,COG1012@2|Bacteria,1MUHV@1224|Proteobacteria,2VI0N@28216|Betaproteobacteria,4A9T8@80864|Comamonadaceae	28216|Betaproteobacteria	C	TIGRFAM methylmalonate-semialdehyde dehydrogenase	-	-	1.2.1.18,1.2.1.27	ko:K00140	ko00280,ko00410,ko00562,ko00640,ko01100,ko01200,map00280,map00410,map00562,map00640,map01100,map01200	M00013	R00705,R00706,R00922,R00935	RC00004,RC02723,RC02817	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
HKD2_k127_2101540_7	1242864.D187_004416	6.068e-28	120.0	COG0278@1|root,COG0278@2|Bacteria,1RKVH@1224|Proteobacteria,43CUY@68525|delta/epsilon subdivisions,2X82Q@28221|Deltaproteobacteria,2YVJZ@29|Myxococcales	28221|Deltaproteobacteria	O	Glutaredoxin	-	-	-	-	-	-	-	-	-	-	-	-	Glutaredoxin
HKD2_k127_2101540_6	1192034.CAP_4931	2.075e-35	144.0	COG0681@1|root,COG0681@2|Bacteria	2|Bacteria	U	signal peptide processing	-	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	-
HKD2_k127_2101540_10	1121380.JNIW01000023_gene190	8.862e-08	59.0	COG0346@1|root,COG0346@2|Bacteria	2|Bacteria	E	lactoylglutathione lyase activity	gloA	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HKD2_k127_2101540_9	1192034.CAP_1515	6.952e-10	70.0	COG2304@1|root,COG2304@2|Bacteria	2|Bacteria	IU	oxidoreductase activity	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VWA,VWA_2
HKD2_k127_2101540_5	1123508.JH636448_gene7567	8.02e-39	148.0	COG0393@1|root,COG0393@2|Bacteria,2J0RP@203682|Planctomycetes	203682|Planctomycetes	S	Putative heavy-metal-binding	-	-	-	-	-	-	-	-	-	-	-	-	YbjQ_1
HKD2_k127_2101540_3	1341646.CBMO010000021_gene5924	1.062e-64	238.0	COG1414@1|root,COG1414@2|Bacteria,2I3CC@201174|Actinobacteria,2337H@1762|Mycobacteriaceae	201174|Actinobacteria	K	PFAM O-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Dimerisation2,Methyltransf_2
HKD2_k127_2101540_8	1254432.SCE1572_17565	1.827e-27	121.0	COG4826@1|root,COG4826@2|Bacteria,1REGX@1224|Proteobacteria,42T9N@68525|delta/epsilon subdivisions,2WPDB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	Belongs to the serpin family	-	-	-	ko:K13963	ko05146,map05146	-	-	-	ko00000,ko00001	-	-	-	Serpin
HKD2_k127_2107132_18	1187851.A33M_3193	1.185e-41	164.0	COG1063@1|root,COG1063@2|Bacteria,1QTU5@1224|Proteobacteria,2TW9Q@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	yphC	-	1.1.1.368	ko:K07538	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00541	R05581	RC00850	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_N_assoc,ADH_zinc_N
HKD2_k127_2107132_22	1254432.SCE1572_35140	2.927e-20	98.0	COG2068@1|root,COG2068@2|Bacteria,1QAUF@1224|Proteobacteria,435B0@68525|delta/epsilon subdivisions,2WZN6@28221|Deltaproteobacteria,2Z2EQ@29|Myxococcales	28221|Deltaproteobacteria	S	MobA-like NTP transferase domain	-	-	2.7.7.76	ko:K07141	ko00790,map00790	-	R11582	-	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
HKD2_k127_2107132_11	1254432.SCE1572_49185	5.31e-71	257.0	COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,42MSP@68525|delta/epsilon subdivisions,2WIUZ@28221|Deltaproteobacteria,2YTZB@29|Myxococcales	28221|Deltaproteobacteria	E	synthase homocitrate synthase family	-	-	-	-	-	-	-	-	-	-	-	-	HMGL-like
HKD2_k127_2107132_0	391625.PPSIR1_18075	2.767e-251	817.0	COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,42MER@68525|delta/epsilon subdivisions,2WIYV@28221|Deltaproteobacteria,2YW7P@29|Myxococcales	28221|Deltaproteobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding	-	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
HKD2_k127_2107132_9	1192034.CAP_4260	7.851e-82	304.0	COG1319@1|root,COG1319@2|Bacteria,1PG5C@1224|Proteobacteria,43EJH@68525|delta/epsilon subdivisions,2X9UI@28221|Deltaproteobacteria,2Z2GS@29|Myxococcales	28221|Deltaproteobacteria	C	CO dehydrogenase flavoprotein C-terminal domain	-	-	1.2.5.3	ko:K03519	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
HKD2_k127_2107132_1	243231.GSU0247	8.148e-159	511.0	COG1032@1|root,COG1032@2|Bacteria,1RCWX@1224|Proteobacteria,43AIJ@68525|delta/epsilon subdivisions,2X5YS@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
HKD2_k127_2107132_3	1123257.AUFV01000009_gene2139	1.073e-105	348.0	COG0412@1|root,COG0412@2|Bacteria,1R8KY@1224|Proteobacteria,1T08Q@1236|Gammaproteobacteria,1XCZA@135614|Xanthomonadales	135614|Xanthomonadales	Q	BAAT / Acyl-CoA thioester hydrolase C terminal	-	-	-	-	-	-	-	-	-	-	-	-	DLH
HKD2_k127_2107132_20	1192034.CAP_2726	1.3e-36	142.0	COG2050@1|root,COG2050@2|Bacteria	2|Bacteria	Q	thiolester hydrolase activity	ydiI	-	-	-	-	-	-	-	-	-	-	-	4HBT,Hydrolase_3
HKD2_k127_2107132_16	1123371.ATXH01000031_gene2166	1.127e-48	185.0	COG0053@1|root,COG0053@2|Bacteria,2GH3U@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	P	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,ZT_dimer
HKD2_k127_2107132_21	243090.RB12455	2.321e-22	102.0	COG0494@1|root,COG0494@2|Bacteria,2J4FW@203682|Planctomycetes	203682|Planctomycetes	L	nUDIX hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2107132_25	1242864.D187_006122	0.0003096	53.0	COG3509@1|root,COG3509@2|Bacteria,1PI9N@1224|Proteobacteria,439C2@68525|delta/epsilon subdivisions,2X4K6@28221|Deltaproteobacteria,2YVGR@29|Myxococcales	28221|Deltaproteobacteria	Q	Carbohydrate family 9 binding domain-like	-	-	-	-	-	-	-	-	-	-	-	-	CBM9_1
HKD2_k127_2107132_23	448385.sce7479	1.084e-14	84.0	28ZS2@1|root,2ZMGV@2|Bacteria,1Q9PN@1224|Proteobacteria,434I5@68525|delta/epsilon subdivisions,2X8WM@28221|Deltaproteobacteria,2Z0QQ@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	CAP
HKD2_k127_2107132_14	1869.MB27_26375	9.384e-56	224.0	COG3831@1|root,COG3831@2|Bacteria,2HIEQ@201174|Actinobacteria,4D9WJ@85008|Micromonosporales	201174|Actinobacteria	S	Domain of unknown function (DUF4132)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4132,WGR
HKD2_k127_2107132_12	690850.Desaf_3498	3.198e-70	268.0	COG4447@1|root,COG4447@2|Bacteria	2|Bacteria	S	cellulose binding	-	-	-	ko:K13735	ko05100,map05100	-	-	-	ko00000,ko00001	-	-	-	Beta_helix,Big_2,CarboxypepD_reg,He_PIG,LysM,PSII_BNR,SLH,TIG,fn3
HKD2_k127_2107132_19	1121933.AUHH01000051_gene296	3.703e-40	166.0	COG5479@1|root,COG5479@2|Bacteria,2GN2D@201174|Actinobacteria,4DVI3@85009|Propionibacteriales	201174|Actinobacteria	M	LGFP repeat	-	-	-	-	-	-	-	-	-	-	-	-	LGFP
HKD2_k127_2107132_17	1172188.KB911820_gene2594	1.316e-43	169.0	COG3409@1|root,COG3583@1|root,COG3409@2|Bacteria,COG3583@2|Bacteria,2I5X7@201174|Actinobacteria,4FJ8G@85021|Intrasporangiaceae	201174|Actinobacteria	M	Peptidoglycan-binding domain 1 protein	-	-	-	-	-	-	-	-	-	-	-	-	Inhibitor_I36
HKD2_k127_2107132_13	298654.FraEuI1c_5715	1.074e-69	252.0	COG0300@1|root,COG0300@2|Bacteria,2I8RA@201174|Actinobacteria	201174|Actinobacteria	S	PFAM Short-chain dehydrogenase reductase SDR	-	-	-	ko:K07124	-	-	-	-	ko00000	-	-	-	adh_short
HKD2_k127_2107132_5	909613.UO65_4795	3.784e-103	342.0	COG1024@1|root,COG1024@2|Bacteria,2GJG7@201174|Actinobacteria,4E086@85010|Pseudonocardiales	201174|Actinobacteria	I	Enoyl-CoA hydratase carnithine racemase	echA21	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005777,GO:0042579,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464	4.2.1.17	ko:K01692	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
HKD2_k127_2107132_2	402777.KB235903_gene1743	5.447e-141	463.0	COG3386@1|root,COG3386@2|Bacteria,1G1H9@1117|Cyanobacteria	1117|Cyanobacteria	G	Major royal jelly protein	-	-	-	-	-	-	-	-	-	-	-	-	MRJP
HKD2_k127_2107132_10	448385.sce5315	2.643e-71	265.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,42QEI@68525|delta/epsilon subdivisions,2X50D@28221|Deltaproteobacteria,2YZXK@29|Myxococcales	28221|Deltaproteobacteria	KLT	Protein kinase domain	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
HKD2_k127_2107132_4	1144275.COCOR_02803	4.698e-104	347.0	COG0491@1|root,COG0491@2|Bacteria,1MUSY@1224|Proteobacteria,438ZA@68525|delta/epsilon subdivisions,2XA0R@28221|Deltaproteobacteria,2Z00H@29|Myxococcales	28221|Deltaproteobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HKD2_k127_2107132_8	1278073.MYSTI_07967	4.629e-84	288.0	COG0583@1|root,COG0583@2|Bacteria,1NSZV@1224|Proteobacteria,43452@68525|delta/epsilon subdivisions,2X59G@28221|Deltaproteobacteria,2Z0AJ@29|Myxococcales	28221|Deltaproteobacteria	K	Bacterial regulatory helix-turn-helix protein, lysR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HKD2_k127_2107132_6	1242864.D187_005732	2.944e-85	288.0	COG0702@1|root,COG0702@2|Bacteria,1QR3E@1224|Proteobacteria,4341F@68525|delta/epsilon subdivisions,2X4MP@28221|Deltaproteobacteria,2YZ9G@29|Myxococcales	28221|Deltaproteobacteria	GM	epimerase	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
HKD2_k127_2107132_24	32057.KB217478_gene6948	4.081e-11	74.0	COG3221@1|root,COG3221@2|Bacteria,1G5J2@1117|Cyanobacteria,1HN2F@1161|Nostocales	1117|Cyanobacteria	P	Phosphonate ABC	-	-	-	ko:K02044	ko02010,map02010	M00223	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.9	-	-	Phosphonate-bd
HKD2_k127_2107132_7	448385.sce7583	2.517e-84	283.0	COG5285@1|root,COG5285@2|Bacteria,1R84J@1224|Proteobacteria,43BA2@68525|delta/epsilon subdivisions,2X6P8@28221|Deltaproteobacteria,2YTTB@29|Myxococcales	28221|Deltaproteobacteria	Q	Phytanoyl-CoA dioxygenase (PhyH)	-	-	-	-	-	-	-	-	-	-	-	-	PhyH
HKD2_k127_211001_0	215803.DB30_4870	7.372e-144	470.0	COG3344@1|root,COG3344@2|Bacteria,1R44F@1224|Proteobacteria,42WGB@68525|delta/epsilon subdivisions,2WQ7V@28221|Deltaproteobacteria,2YY5R@29|Myxococcales	28221|Deltaproteobacteria	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	2.7.7.49	ko:K00986	-	-	-	-	ko00000,ko01000	-	-	-	RVT_1
HKD2_k127_211001_1	215803.DB30_4869	1.065e-134	465.0	COG0667@1|root,COG1413@1|root,COG0667@2|Bacteria,COG1413@2|Bacteria,1NWQE@1224|Proteobacteria,42ZW2@68525|delta/epsilon subdivisions,2WVDI@28221|Deltaproteobacteria,2YVXI@29|Myxococcales	28221|Deltaproteobacteria	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red,HEAT_2
HKD2_k127_211001_2	215803.DB30_4866	2.568e-05	49.0	2AIX1@1|root,319EP@2|Bacteria,1Q2I0@1224|Proteobacteria,4384V@68525|delta/epsilon subdivisions,2X3EW@28221|Deltaproteobacteria,2YVRV@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2118868_1	983917.RGE_06490	1.839e-32	139.0	COG1024@1|root,COG1024@2|Bacteria,1RGAR@1224|Proteobacteria,2VSC3@28216|Betaproteobacteria	28216|Betaproteobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
HKD2_k127_2118868_0	448385.sce6906	1.209e-126	414.0	COG0189@1|root,COG0189@2|Bacteria,1MX62@1224|Proteobacteria,42NIA@68525|delta/epsilon subdivisions,2WM87@28221|Deltaproteobacteria,2YUDN@29|Myxococcales	28221|Deltaproteobacteria	HJ	Belongs to the RimK family	rimK	-	6.3.2.32	ko:K05844,ko:K14940	ko00680,ko01120,map00680,map01120	-	R09401	RC00064,RC00090	ko00000,ko00001,ko01000,ko03009	-	-	-	RimK
HKD2_k127_2118868_2	502025.Hoch_1786	1.047e-24	105.0	COG0527@1|root,COG0527@2|Bacteria,1MW3H@1224|Proteobacteria,42NDT@68525|delta/epsilon subdivisions,2WIWZ@28221|Deltaproteobacteria,2YTWJ@29|Myxococcales	28221|Deltaproteobacteria	E	Belongs to the aspartokinase family	-	-	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase
HKD2_k127_2126423_3	448385.sce6880	3.209e-95	317.0	COG0539@1|root,COG2183@1|root,COG0539@2|Bacteria,COG2183@2|Bacteria,1MVAV@1224|Proteobacteria,42M29@68525|delta/epsilon subdivisions,2WJ0X@28221|Deltaproteobacteria,2YU9B@29|Myxococcales	28221|Deltaproteobacteria	J	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence	rpsA	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
HKD2_k127_2126423_4	1192034.CAP_7599	2.034e-53	192.0	COG0537@1|root,COG0537@2|Bacteria,1RHYQ@1224|Proteobacteria,42SEG@68525|delta/epsilon subdivisions,2WPFW@28221|Deltaproteobacteria,2Z10H@29|Myxococcales	28221|Deltaproteobacteria	FG	Protein similar to CwfJ C-terminus 1	-	-	2.7.7.53	ko:K19710	ko00230,map00230	-	R00126,R01618	RC00002,RC02753,RC02795	ko00000,ko00001,ko01000	-	-	-	CwfJ_C_1,HIT
HKD2_k127_2126423_2	1192034.CAP_7600	1.308e-98	335.0	COG0628@1|root,COG0628@2|Bacteria,1PTH3@1224|Proteobacteria,42T9W@68525|delta/epsilon subdivisions,2WPRE@28221|Deltaproteobacteria,2YUY8@29|Myxococcales	28221|Deltaproteobacteria	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
HKD2_k127_2126423_1	1328313.DS2_09342	1.022e-119	402.0	COG0664@1|root,COG0668@1|root,COG0664@2|Bacteria,COG0668@2|Bacteria,1R6J6@1224|Proteobacteria,1RNQ0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	MT	mechanosensitive ion channel	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel,cNMP_binding
HKD2_k127_2126423_0	344747.PM8797T_24201	2.711e-314	989.0	COG0567@1|root,COG0567@2|Bacteria,2IWRF@203682|Planctomycetes	203682|Planctomycetes	C	Dehydrogenase E1 component	sucA	-	1.2.4.2	ko:K00164	ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R00621,R01933,R01940,R03316,R08549	RC00004,RC00027,RC00627,RC02743,RC02833,RC02883	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr
HKD2_k127_2126423_8	69319.XP_008559522.1	8.977e-13	80.0	KOG1217@1|root,KOG1217@2759|Eukaryota,38BUP@33154|Opisthokonta,3BA2W@33208|Metazoa,3CUNH@33213|Bilateria,41VHE@6656|Arthropoda,3SKFR@50557|Insecta,46JI8@7399|Hymenoptera	33208|Metazoa	T	Low-density lipoprotein receptor domain class A	-	-	-	-	-	-	-	-	-	-	-	-	EGF_3,EGF_CA,NIDO,Zona_pellucida,hEGF
HKD2_k127_2126423_5	1254432.SCE1572_17500	9.971e-44	165.0	COG2825@1|root,COG2825@2|Bacteria,1MZVJ@1224|Proteobacteria,42VH3@68525|delta/epsilon subdivisions,2WP6K@28221|Deltaproteobacteria,2YVZ7@29|Myxococcales	28221|Deltaproteobacteria	M	Outer membrane protein (OmpH-like)	-	-	-	ko:K06142	-	-	-	-	ko00000	-	-	-	OmpH
HKD2_k127_2155548_0	1192034.CAP_5375	4.435e-184	586.0	COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,42M7M@68525|delta/epsilon subdivisions,2WJ9X@28221|Deltaproteobacteria,2YU54@29|Myxococcales	28221|Deltaproteobacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
HKD2_k127_2155548_3	1254432.SCE1572_47490	4.674e-84	302.0	COG1195@1|root,COG1195@2|Bacteria,1MX8N@1224|Proteobacteria,42SYJ@68525|delta/epsilon subdivisions,2WP80@28221|Deltaproteobacteria,2YV1Z@29|Myxococcales	28221|Deltaproteobacteria	L	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP	recF	GO:0000731,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0018130,GO:0019438,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:1901360,GO:1901362,GO:1901576	-	ko:K03629	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	SMC_N
HKD2_k127_2155548_1	1254432.SCE1572_47485	1.053e-151	488.0	COG0592@1|root,COG0592@2|Bacteria,1MVD9@1224|Proteobacteria,42NQW@68525|delta/epsilon subdivisions,2WJZM@28221|Deltaproteobacteria,2YUS5@29|Myxococcales	28221|Deltaproteobacteria	L	Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria	dnaN	-	2.7.7.7	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3
HKD2_k127_2155548_5	1192034.CAP_5369	2.003e-20	100.0	2ANI1@1|root,31DGW@2|Bacteria,1QARK@1224|Proteobacteria,43E3E@68525|delta/epsilon subdivisions,2WZKG@28221|Deltaproteobacteria,2Z2BA@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2155548_2	1254432.SCE1572_47520	3.006e-111	386.0	COG1138@1|root,COG1138@2|Bacteria,1MUQS@1224|Proteobacteria,42P4Q@68525|delta/epsilon subdivisions,2WK5G@28221|Deltaproteobacteria,2YU4N@29|Myxococcales	28221|Deltaproteobacteria	O	Cytochrome c-type biogenesis protein	ccmF	-	-	ko:K02198	-	-	-	-	ko00000,ko02000	9.B.14.1	-	-	CcmF_C,Cytochrom_C_asm
HKD2_k127_216026_3	1192034.CAP_1747	4.372e-07	59.0	COG3170@1|root,COG3170@2|Bacteria,1QX3V@1224|Proteobacteria,43BWB@68525|delta/epsilon subdivisions,2X773@28221|Deltaproteobacteria,2YVT2@29|Myxococcales	28221|Deltaproteobacteria	NU	zinc-ribbon domain	-	-	-	-	-	-	-	-	-	-	-	-	zinc_ribbon_4
HKD2_k127_216026_0	448385.sce0011	3.335e-82	296.0	COG0564@1|root,COG0564@2|Bacteria,1MVJ5@1224|Proteobacteria,42PI3@68525|delta/epsilon subdivisions,2WJN3@28221|Deltaproteobacteria,2YZZD@29|Myxococcales	28221|Deltaproteobacteria	J	Belongs to the pseudouridine synthase RluA family	-	-	5.4.99.23,5.4.99.28,5.4.99.29	ko:K06177,ko:K06180	-	-	-	-	ko00000,ko01000,ko03009,ko03016	-	-	-	PseudoU_synth_2
HKD2_k127_216026_1	448385.sce0012	1.049e-50	191.0	COG0745@1|root,COG0745@2|Bacteria,1N1N5@1224|Proteobacteria,42UP1@68525|delta/epsilon subdivisions,2WQAF@28221|Deltaproteobacteria,2YVKX@29|Myxococcales	28221|Deltaproteobacteria	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
HKD2_k127_216026_2	448385.sce2877	2.046e-18	87.0	COG4826@1|root,COG4826@2|Bacteria,1REGX@1224|Proteobacteria,42T9N@68525|delta/epsilon subdivisions,2WPDB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	Belongs to the serpin family	-	-	-	ko:K13963	ko05146,map05146	-	-	-	ko00000,ko00001	-	-	-	Serpin
HKD2_k127_216472_0	391612.CY0110_27069	2.852e-121	394.0	COG0176@1|root,COG0176@2|Bacteria,1G292@1117|Cyanobacteria,3KGUH@43988|Cyanothece	1117|Cyanobacteria	H	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway	tal	GO:0003674,GO:0003824,GO:0004801,GO:0016740,GO:0016744	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	EF-hand_5,TAL_FSA
HKD2_k127_216472_1	1410633.JHWR01000026_gene868	1.175e-06	55.0	29U3P@1|root,30FD3@2|Bacteria,1UDVB@1239|Firmicutes,25IP2@186801|Clostridia,27SGW@186928|unclassified Lachnospiraceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2187375_0	1192034.CAP_7185	6.139e-147	473.0	COG4591@1|root,COG4591@2|Bacteria,1MVV7@1224|Proteobacteria,42MV0@68525|delta/epsilon subdivisions,2WITK@28221|Deltaproteobacteria,2YUSA@29|Myxococcales	28221|Deltaproteobacteria	M	ABC-type transport system involved in lipoprotein release permease component	lolC	-	-	ko:K09808	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.125	-	-	FtsX,MacB_PCD
HKD2_k127_2187375_1	1190603.AJYD01000016_gene1927	1.524e-67	233.0	28M4C@1|root,32GA5@2|Bacteria,1QKTT@1224|Proteobacteria,1TIYY@1236|Gammaproteobacteria,1Y024@135623|Vibrionales	135623|Vibrionales	S	Domain of unknown function (DUF4395)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4395
HKD2_k127_220709_20	1297570.MESS4_430183	2.64e-05	51.0	COG0702@1|root,COG0702@2|Bacteria,1N12V@1224|Proteobacteria,2UGDR@28211|Alphaproteobacteria,43Q20@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	GM	NmrA-like family	-	-	-	-	-	-	-	-	-	-	-	-	NmrA
HKD2_k127_220709_10	345341.KUTG_08609	4.233e-41	166.0	COG1520@1|root,COG3942@1|root,COG1520@2|Bacteria,COG3942@2|Bacteria,2I3H6@201174|Actinobacteria,4EE3C@85010|Pseudonocardiales	201174|Actinobacteria	D	Tachylectin	-	-	-	-	-	-	-	-	-	-	-	-	Tachylectin
HKD2_k127_220709_9	1254432.SCE1572_25325	1.519e-45	169.0	COG0748@1|root,COG0748@2|Bacteria,1RFVC@1224|Proteobacteria,42UK2@68525|delta/epsilon subdivisions,2WR4V@28221|Deltaproteobacteria,2Z1V6@29|Myxococcales	28221|Deltaproteobacteria	P	Pyridoxamine 5'-phosphate oxidase	-	-	-	ko:K07226	-	-	-	-	ko00000	-	-	-	DUF2470,Pyrid_oxidase_2
HKD2_k127_220709_6	1254432.SCE1572_45705	2.226e-55	206.0	COG1262@1|root,COG1262@2|Bacteria	2|Bacteria	T	PFAM Formylglycine-generating sulfatase enzyme	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase,SapC
HKD2_k127_220709_17	28564.XP_002488081.1	5.716e-10	71.0	COG3934@1|root,2QS4Q@2759|Eukaryota,39S1A@33154|Opisthokonta,3NVXW@4751|Fungi,3QPKU@4890|Ascomycota,20JJC@147545|Eurotiomycetes,3S521@5042|Eurotiales	4751|Fungi	G	a crucial enzyme for depolymerization of seed galactomannans and wood galactoglucomannans	manA	GO:0000272,GO:0003674,GO:0003824,GO:0004553,GO:0004567,GO:0005575,GO:0005576,GO:0005975,GO:0005976,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0010412,GO:0015923,GO:0016052,GO:0016787,GO:0016798,GO:0016985,GO:0016998,GO:0043170,GO:0044036,GO:0044237,GO:0044238,GO:0044247,GO:0044248,GO:0044260,GO:0044262,GO:0044264,GO:0044275,GO:0046355,GO:0071554,GO:0071704,GO:1901575	3.2.1.78	ko:K19355	ko00051,map00051	-	R01332	RC00467	ko00000,ko00001,ko01000	-	-	-	CBM_1,Cellulase
HKD2_k127_220709_7	2055.JNXA01000042_gene4181	1.743e-52	199.0	COG1305@1|root,COG1305@2|Bacteria,2GMGI@201174|Actinobacteria,4GCFN@85026|Gordoniaceae	201174|Actinobacteria	E	Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Transglut_core
HKD2_k127_220709_2	1192034.CAP_7614	2.213e-76	276.0	COG0515@1|root,COG0515@2|Bacteria,1Q35Q@1224|Proteobacteria,438W9@68525|delta/epsilon subdivisions,2X41T@28221|Deltaproteobacteria,2YXZI@29|Myxococcales	28221|Deltaproteobacteria	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K08884	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HKD2_k127_220709_4	298654.FraEuI1c_4507	3.358e-64	231.0	COG0412@1|root,COG0412@2|Bacteria,2HVNP@201174|Actinobacteria	201174|Actinobacteria	Q	dienelactone hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	DLH
HKD2_k127_220709_3	448385.sce7528	8.278e-72	261.0	COG0241@1|root,COG0645@1|root,COG0667@1|root,COG0241@2|Bacteria,COG0645@2|Bacteria,COG0667@2|Bacteria	2|Bacteria	C	Aldo Keto reductase	gmhB	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008270,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0034200,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914	1.1.1.65,3.1.3.82,3.1.3.83,6.3.4.4	ko:K01939,ko:K03273,ko:K05275	ko00230,ko00250,ko00540,ko00750,ko01100,ko01120,map00230,map00250,map00540,map00750,map01100,map01120	M00049,M00064	R01135,R01708,R05647,R09771	RC00017,RC00116,RC00458,RC00459	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	AAA_33,Aldo_ket_red,Hydrolase_like
HKD2_k127_220709_15	448385.sce5360	2.061e-12	78.0	COG1716@1|root,COG2304@1|root,COG4676@1|root,COG4783@1|root,COG1716@2|Bacteria,COG2304@2|Bacteria,COG4676@2|Bacteria,COG4783@2|Bacteria,1PCRX@1224|Proteobacteria,433WB@68525|delta/epsilon subdivisions,2X9AU@28221|Deltaproteobacteria,2YX4K@29|Myxococcales	28221|Deltaproteobacteria	E	Vault protein inter-alpha-trypsin domain	-	-	-	-	-	-	-	-	-	-	-	-	VIT
HKD2_k127_220709_12	146922.JOFU01000021_gene2348	3.233e-18	100.0	COG0726@1|root,COG0726@2|Bacteria,2GN6G@201174|Actinobacteria	201174|Actinobacteria	G	polysaccharide deacetylase	-	-	3.5.1.104	ko:K22278	-	-	-	-	ko00000,ko01000	-	-	-	Polysacc_deac_1
HKD2_k127_220709_19	1408444.JHYC01000020_gene214	1.773e-05	54.0	COG3652@1|root,COG3652@2|Bacteria,1RGSQ@1224|Proteobacteria,1SH1C@1236|Gammaproteobacteria,1JFCY@118969|Legionellales	118969|Legionellales	S	Domain of unknown function (DUF4142)	-	-	-	ko:K08995	-	-	-	-	ko00000	-	-	-	DUF4142
HKD2_k127_220709_18	96561.Dole_0363	2.337e-07	63.0	COG4733@1|root,COG4733@2|Bacteria,1QW0V@1224|Proteobacteria,42U6C@68525|delta/epsilon subdivisions,2WQX8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Parallel beta-helix repeats	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,Big_3_2,DUF4215
HKD2_k127_220709_1	502025.Hoch_3011	5.35e-169	546.0	COG1233@1|root,COG1233@2|Bacteria,1MV2R@1224|Proteobacteria,42NXM@68525|delta/epsilon subdivisions,2WQMZ@28221|Deltaproteobacteria,2YY10@29|Myxococcales	28221|Deltaproteobacteria	C	Flavin containing amine oxidoreductase	-	-	1.3.99.23	ko:K09516	ko00830,map00830	-	R07163	RC01835	ko00000,ko00001,ko01000	-	-	-	Amino_oxidase
HKD2_k127_220709_5	383372.Rcas_3377	2.003e-57	214.0	COG2267@1|root,COG2267@2|Bacteria,2GBHH@200795|Chloroflexi,3780S@32061|Chloroflexia	32061|Chloroflexia	I	PFAM alpha beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
HKD2_k127_220709_8	215803.DB30_6914	1.893e-48	182.0	COG4221@1|root,COG4221@2|Bacteria,1PWXN@1224|Proteobacteria,43811@68525|delta/epsilon subdivisions,2X3B3@28221|Deltaproteobacteria,2YV70@29|Myxococcales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF4336)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4336
HKD2_k127_220709_0	215803.DB30_7204	0.0	1327.0	COG0404@1|root,COG0665@1|root,COG0404@2|Bacteria,COG0665@2|Bacteria,1MUXJ@1224|Proteobacteria,42YZ6@68525|delta/epsilon subdivisions,2WU2X@28221|Deltaproteobacteria,2YXQD@29|Myxococcales	28221|Deltaproteobacteria	E	FAD dependent oxidoreductase central domain	-	-	-	-	-	-	-	-	-	-	-	-	DAO,FAO_M,GCV_T,GCV_T_C
HKD2_k127_220709_16	498211.CJA_1292	2.344e-11	77.0	COG2374@1|root,COG3391@1|root,COG5184@1|root,COG2374@2|Bacteria,COG3391@2|Bacteria,COG5184@2|Bacteria	2|Bacteria	DZ	guanyl-nucleotide exchange factor activity	mtsC	-	-	-	-	-	-	-	-	-	-	-	Big_5,CHU_C,LTD,Reprolysin_4,SLH,TSP_3
HKD2_k127_220709_13	1121101.HMPREF1532_01474	3.559e-17	96.0	COG4632@1|root,COG4632@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,Metallophos,NAGPA,Pur_ac_phosph_N,SLH
HKD2_k127_220709_11	246197.MXAN_0560	1.302e-28	119.0	COG1876@1|root,COG3409@1|root,COG1876@2|Bacteria,COG3409@2|Bacteria,1N9AN@1224|Proteobacteria,42XYC@68525|delta/epsilon subdivisions,2WSN6@28221|Deltaproteobacteria,2Z267@29|Myxococcales	28221|Deltaproteobacteria	M	D-alanyl-D-alanine carboxypeptidase	-	-	-	ko:K17733	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	PG_binding_1,VanY
HKD2_k127_220841_4	290397.Adeh_2703	1.424e-19	94.0	COG1496@1|root,COG1496@2|Bacteria,1MW2H@1224|Proteobacteria,42SE9@68525|delta/epsilon subdivisions,2WMQE@28221|Deltaproteobacteria,2YVJ7@29|Myxococcales	28221|Deltaproteobacteria	S	Belongs to the multicopper oxidase YfiH RL5 family	-	-	-	ko:K05810	-	-	-	-	ko00000,ko01000	-	-	-	Cu-oxidase_4
HKD2_k127_220841_0	448385.sce0038	1.513e-141	459.0	COG0393@1|root,COG0515@1|root,COG0393@2|Bacteria,COG0515@2|Bacteria,1QA6R@1224|Proteobacteria,439IS@68525|delta/epsilon subdivisions,2X4V7@28221|Deltaproteobacteria,2YZNY@29|Myxococcales	28221|Deltaproteobacteria	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HKD2_k127_220841_1	1278073.MYSTI_07003	4.757e-122	428.0	COG1073@1|root,COG1073@2|Bacteria,1NKA5@1224|Proteobacteria,43BIS@68525|delta/epsilon subdivisions,2X6X7@28221|Deltaproteobacteria,2Z3DF@29|Myxococcales	28221|Deltaproteobacteria	S	alpha beta	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_220841_2	448385.sce7160	3.007e-38	149.0	COG1468@1|root,COG1468@2|Bacteria,1QAI2@1224|Proteobacteria,43E1D@68525|delta/epsilon subdivisions,2X952@28221|Deltaproteobacteria,2Z1ZI@29|Myxococcales	28221|Deltaproteobacteria	L	defense response to virus	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_220841_6	485913.Krac_4700	1.906e-17	95.0	2DRZ7@1|root,33DSV@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_220841_3	710685.MycrhN_3289	6.883e-24	114.0	COG0515@1|root,COG3055@1|root,COG0515@2|Bacteria,COG3055@2|Bacteria,2I4I0@201174|Actinobacteria,23F8F@1762|Mycobacteriaceae	201174|Actinobacteria	KLT	PFAM Protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	Kelch_1,Pkinase
HKD2_k127_220841_5	216596.RL1967	3.095e-19	95.0	COG4977@1|root,COG4977@2|Bacteria,1R9KM@1224|Proteobacteria,2VF6H@28211|Alphaproteobacteria,4BA78@82115|Rhizobiaceae	28211|Alphaproteobacteria	K	helix_turn_helix, arabinose operon control protein	-	-	-	ko:K07506	-	-	-	-	ko00000,ko03000	-	-	-	HTH_18,HTH_AraC
HKD2_k127_222380_8	1192034.CAP_3725	1.609e-13	82.0	COG1028@1|root,COG1028@2|Bacteria,1MU6X@1224|Proteobacteria,42MB9@68525|delta/epsilon subdivisions,2WJ64@28221|Deltaproteobacteria,2YYDX@29|Myxococcales	28221|Deltaproteobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	ko:K13774	ko00281,map00281	-	R08087,R08096,R10125,R10126	RC00080,RC00087	ko00000,ko00001	-	-	-	adh_short_C2
HKD2_k127_222380_5	448385.sce1040	9.539e-57	211.0	COG0328@1|root,COG0328@2|Bacteria,1PE5Y@1224|Proteobacteria,42RJY@68525|delta/epsilon subdivisions,2WNDP@28221|Deltaproteobacteria,2Z32P@29|Myxococcales	28221|Deltaproteobacteria	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	-	-	3.1.26.4	ko:K03469	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_H
HKD2_k127_222380_0	1254432.SCE1572_07480	5.293e-186	594.0	COG0696@1|root,COG0696@2|Bacteria,1MUQ1@1224|Proteobacteria,42N6C@68525|delta/epsilon subdivisions,2WJ66@28221|Deltaproteobacteria,2YWA3@29|Myxococcales	28221|Deltaproteobacteria	G	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate	gpmI	-	5.4.2.12	ko:K15633	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,Phosphodiest,iPGM_N
HKD2_k127_222380_1	448385.sce1043	1.011e-76	283.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,42Q67@68525|delta/epsilon subdivisions,2WKZ1@28221|Deltaproteobacteria,2YUWW@29|Myxococcales	28221|Deltaproteobacteria	KLT	Serine Threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HKD2_k127_222380_10	1476876.JOJO01000007_gene2328	5.146e-05	53.0	COG1846@1|root,COG1846@2|Bacteria,2IHP0@201174|Actinobacteria	201174|Actinobacteria	K	marr family	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
HKD2_k127_222380_7	502025.Hoch_5243	8.604e-42	162.0	COG3310@1|root,COG3310@2|Bacteria,1PCF4@1224|Proteobacteria,435CI@68525|delta/epsilon subdivisions,2WZQ4@28221|Deltaproteobacteria,2Z2HV@29|Myxococcales	28221|Deltaproteobacteria	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_222380_2	448385.sce0420	1.246e-74	267.0	COG1388@1|root,COG1388@2|Bacteria	2|Bacteria	M	LysM domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF928,LysM,SPOR
HKD2_k127_222380_3	1254432.SCE1572_03120	4.654e-71	264.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,42QEI@68525|delta/epsilon subdivisions	1224|Proteobacteria	KLT	Serine Threonine protein kinase	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HKD2_k127_222380_9	448385.sce8474	1.286e-07	64.0	COG1357@1|root,COG5351@1|root,COG1357@2|Bacteria,COG5351@2|Bacteria,1N7U9@1224|Proteobacteria,42RQA@68525|delta/epsilon subdivisions,2X63E@28221|Deltaproteobacteria,2YWYC@29|Myxococcales	28221|Deltaproteobacteria	S	Uncharacterized protein conserved in bacteria (DUF2169)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2169,Pentapeptide
HKD2_k127_222380_4	1356854.N007_12485	5.415e-64	231.0	COG0008@1|root,COG0008@2|Bacteria,1TVW7@1239|Firmicutes,4HEN5@91061|Bacilli	91061|Bacilli	J	Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon	gluQ	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
HKD2_k127_222380_6	1192034.CAP_2144	1.465e-50	196.0	COG0265@1|root,COG0265@2|Bacteria	2|Bacteria	O	serine-type endopeptidase activity	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	DNase-RNase,PDZ_2,Trypsin_2
HKD2_k127_23304_1	272134.KB731324_gene4309	1.164e-76	269.0	COG1233@1|root,COG1233@2|Bacteria,1G39T@1117|Cyanobacteria,1HAC5@1150|Oscillatoriales	1117|Cyanobacteria	Q	Flavin containing amine oxidoreductase	-	-	1.3.99.23	ko:K09516	ko00830,map00830	-	R07163	RC01835	ko00000,ko00001,ko01000	-	-	-	Amino_oxidase,NAD_binding_8
HKD2_k127_23304_0	502025.Hoch_0176	4.201e-229	732.0	COG0553@1|root,COG0553@2|Bacteria,1MV6M@1224|Proteobacteria,42M5P@68525|delta/epsilon subdivisions,2WIW8@28221|Deltaproteobacteria,2YU7C@29|Myxococcales	28221|Deltaproteobacteria	KL	helicase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Helicase_C,SNF2_N,SNF2_assoc,SWIM
HKD2_k127_235112_0	1254432.SCE1572_12320	3.341e-141	453.0	COG0404@1|root,COG0404@2|Bacteria,1MV96@1224|Proteobacteria,42QM6@68525|delta/epsilon subdivisions,2WJ8G@28221|Deltaproteobacteria,2Z31K@29|Myxococcales	28221|Deltaproteobacteria	H	The glycine cleavage system catalyzes the degradation of glycine	gcvT	-	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	GCV_T,GCV_T_C
HKD2_k127_235112_1	378806.STAUR_3120	2.494e-48	177.0	COG1764@1|root,COG1764@2|Bacteria,1RH9U@1224|Proteobacteria,42TWN@68525|delta/epsilon subdivisions,2WQDD@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	OsmC-like protein	osmC	-	-	ko:K04063	-	-	-	-	ko00000	-	-	-	OsmC
HKD2_k127_235112_2	909663.KI867150_gene1774	1.91e-07	61.0	COG3568@1|root,COG3568@2|Bacteria,1MVN7@1224|Proteobacteria,42T9X@68525|delta/epsilon subdivisions,2WP59@28221|Deltaproteobacteria,2MQNB@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	Endonuclease/Exonuclease/phosphatase family	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
HKD2_k127_2372642_1	448385.sce4215	6.107e-97	356.0	COG0079@1|root,COG0079@2|Bacteria,1MW7I@1224|Proteobacteria,42NCH@68525|delta/epsilon subdivisions,2WJDR@28221|Deltaproteobacteria,2Z1G3@29|Myxococcales	28221|Deltaproteobacteria	E	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily	hisC	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
HKD2_k127_2372642_0	309801.trd_A0412	1.693e-144	492.0	COG1067@1|root,COG1067@2|Bacteria,2G64R@200795|Chloroflexi,27XSI@189775|Thermomicrobia	189775|Thermomicrobia	O	Belongs to the peptidase S16 family	-	-	-	-	-	-	-	-	-	-	-	-	AAA_32,Lon_C
HKD2_k127_2396231_4	234267.Acid_5023	4.749e-47	194.0	COG3303@1|root,COG3303@2|Bacteria,3Y84F@57723|Acidobacteria	57723|Acidobacteria	C	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2396231_6	1121877.JQKF01000002_gene1704	5.134e-24	115.0	COG4942@1|root,COG4942@2|Bacteria,2HGJP@201174|Actinobacteria,4CNHU@84992|Acidimicrobiia	84992|Acidimicrobiia	D	peptidase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2396231_0	626418.bglu_1g32370	1.926e-188	605.0	COG4579@1|root,COG4579@2|Bacteria,1MVRB@1224|Proteobacteria,2VJMA@28216|Betaproteobacteria,1K440@119060|Burkholderiaceae	28216|Betaproteobacteria	F	Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation	aceK	-	2.7.11.5	ko:K00906	-	-	-	-	ko00000,ko01000	-	-	-	AceK
HKD2_k127_2396231_1	861299.J421_0132	3.488e-79	274.0	COG1216@1|root,COG1216@2|Bacteria,1ZV7Y@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HKD2_k127_2396231_3	861299.J421_0133	2.008e-62	237.0	COG5653@1|root,COG5653@2|Bacteria	2|Bacteria	M	Protein involved in cellulose biosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_6
HKD2_k127_2396231_5	448385.sce0579	1.66e-42	167.0	COG0789@1|root,COG5012@1|root,COG0789@2|Bacteria,COG5012@2|Bacteria,1R9SN@1224|Proteobacteria,42X6D@68525|delta/epsilon subdivisions,2WSP0@28221|Deltaproteobacteria,2YVHJ@29|Myxococcales	28221|Deltaproteobacteria	K	helix_turn_helix, mercury resistance	-	-	-	ko:K22491	-	-	-	-	ko00000,ko03000	-	-	-	B12-binding,B12-binding_2,MerR_1
HKD2_k127_2396231_2	1242864.D187_008946	7.024e-72	251.0	COG0642@1|root,COG2205@2|Bacteria,1MXH7@1224|Proteobacteria,43AYG@68525|delta/epsilon subdivisions	1224|Proteobacteria	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	2.7.13.3	ko:K07636	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
HKD2_k127_2488502_3	1444711.CCJF01000005_gene1119	3.359e-05	51.0	COG2823@1|root,COG2823@2|Bacteria,2JGHK@204428|Chlamydiae	204428|Chlamydiae	S	BON domain	osmY	-	-	-	-	-	-	-	-	-	-	-	BON
HKD2_k127_2488502_1	204669.Acid345_2557	1.218e-41	159.0	2B7KW@1|root,320RZ@2|Bacteria,3Y7ZF@57723|Acidobacteria,2JN97@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2488502_2	1192034.CAP_9037	1.905e-21	102.0	COG0760@1|root,COG0760@2|Bacteria,1Q4IW@1224|Proteobacteria,43A0D@68525|delta/epsilon subdivisions,2X2FD@28221|Deltaproteobacteria,2Z2B6@29|Myxococcales	28221|Deltaproteobacteria	M	PPIC-type PPIASE domain	-	-	-	-	-	-	-	-	-	-	-	-	Rotamase_3
HKD2_k127_250659_4	756067.MicvaDRAFT_5021	3.131e-24	105.0	COG0642@1|root,COG0784@1|root,COG2202@1|root,COG2203@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG2203@2|Bacteria,COG2205@2|Bacteria,1G09B@1117|Cyanobacteria,1H9EM@1150|Oscillatoriales	1117|Cyanobacteria	T	Signal Transduction Histidine Kinase	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	GAF,GAF_2,HAMP,HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg,dCache_1
HKD2_k127_250659_2	867903.ThesuDRAFT_01318	7.028e-27	124.0	COG3255@1|root,COG3255@2|Bacteria,1V7IH@1239|Firmicutes	1239|Firmicutes	I	SCP-2 sterol transfer family	-	-	-	-	-	-	-	-	-	-	-	-	SCP2
HKD2_k127_250659_0	1254432.SCE1572_46580	3.783e-137	458.0	COG3605@1|root,COG3605@2|Bacteria,1QTTV@1224|Proteobacteria,42PST@68525|delta/epsilon subdivisions,2WJ3A@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Belongs to the PEP-utilizing enzyme family	ptsP	-	2.7.3.9	ko:K08484	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	-	-	-	GAF_2,PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C
HKD2_k127_250659_5	1192034.CAP_8931	3.992e-20	98.0	COG2823@1|root,COG2823@2|Bacteria,1NMBH@1224|Proteobacteria,42X0Q@68525|delta/epsilon subdivisions,2WT3U@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	BON domain	-	-	-	-	-	-	-	-	-	-	-	-	BON
HKD2_k127_250659_1	1192034.CAP_8932	3.961e-51	187.0	COG3861@1|root,COG3861@2|Bacteria,1QE0P@1224|Proteobacteria,42TDZ@68525|delta/epsilon subdivisions,2WPW5@28221|Deltaproteobacteria,2Z2TG@29|Myxococcales	28221|Deltaproteobacteria	S	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_250659_7	1242864.D187_001421	1.353e-07	63.0	COG5479@1|root,COG5479@2|Bacteria	2|Bacteria	M	isomerase activity	-	-	-	-	-	-	-	-	-	-	-	-	Cellulase,DNase_NucA_NucB,LGFP,YkuD
HKD2_k127_250659_6	235985.BBPN01000011_gene4147	1.345e-12	79.0	COG0791@1|root,COG0791@2|Bacteria,2I61A@201174|Actinobacteria	201174|Actinobacteria	M	Peptidoglycan-binding domain 1 protein	-	-	-	-	-	-	-	-	-	-	-	-	VCBS
HKD2_k127_250865_0	269800.Tfu_0862	3.873e-45	171.0	COG1272@1|root,COG1272@2|Bacteria,2GJGQ@201174|Actinobacteria,4EIGX@85012|Streptosporangiales	201174|Actinobacteria	S	Haemolysin-III related	hlyIII	-	-	ko:K11068	-	-	-	-	ko00000,ko02042	-	-	-	HlyIII
HKD2_k127_253047_2	313612.L8106_10612	2.533e-07	60.0	COG0652@1|root,COG2133@1|root,COG2885@1|root,COG2931@1|root,COG3291@1|root,COG0652@2|Bacteria,COG2133@2|Bacteria,COG2885@2|Bacteria,COG2931@2|Bacteria,COG3291@2|Bacteria,1G0DX@1117|Cyanobacteria,1H8AY@1150|Oscillatoriales	1117|Cyanobacteria	Q	COG2931 RTX toxins and related Ca2 -binding	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin_3,DUF11,DUF4347,HemolysinCabind,Laminin_G_3,VCBS
HKD2_k127_253047_0	391625.PPSIR1_05733	6.463e-169	551.0	COG3291@1|root,COG3291@2|Bacteria,1QEIS@1224|Proteobacteria,4389M@68525|delta/epsilon subdivisions,2X3J1@28221|Deltaproteobacteria,2YWAB@29|Myxococcales	28221|Deltaproteobacteria	S	IgGFc binding protein	-	-	-	-	-	-	-	-	-	-	-	-	IgGFc_binding
HKD2_k127_253047_1	1192034.CAP_8780	1.737e-15	77.0	COG0667@1|root,COG0667@2|Bacteria,1MV2Y@1224|Proteobacteria,439G4@68525|delta/epsilon subdivisions,2X4S1@28221|Deltaproteobacteria,2YZGX@29|Myxococcales	28221|Deltaproteobacteria	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
HKD2_k127_254885_2	1267535.KB906767_gene5052	3.626e-86	293.0	COG3591@1|root,COG3591@2|Bacteria,3Y2TU@57723|Acidobacteria	57723|Acidobacteria	E	Peptidase S46	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S46
HKD2_k127_254885_4	215803.DB30_5798	4.804e-31	134.0	COG1633@1|root,COG1633@2|Bacteria,1P131@1224|Proteobacteria,439DQ@68525|delta/epsilon subdivisions,2X4NM@28221|Deltaproteobacteria,2YZB1@29|Myxococcales	28221|Deltaproteobacteria	S	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_254885_1	448385.sce0906	3.564e-90	319.0	COG0122@1|root,COG0350@1|root,COG0122@2|Bacteria,COG0350@2|Bacteria,1MVF7@1224|Proteobacteria,43ARM@68525|delta/epsilon subdivisions,2X65K@28221|Deltaproteobacteria,2Z392@29|Myxococcales	28221|Deltaproteobacteria	L	6-O-methylguanine DNA methyltransferase, DNA binding domain	-	-	2.1.1.63	ko:K00567	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_binding_1,HhH-GPD
HKD2_k127_254885_0	1254432.SCE1572_07045	4.489e-131	431.0	COG1451@1|root,COG1451@2|Bacteria,1RDZ9@1224|Proteobacteria,42SB4@68525|delta/epsilon subdivisions,2WNVN@28221|Deltaproteobacteria,2YYVM@29|Myxococcales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF2786)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2786,SprT-like
HKD2_k127_2553232_0	448385.sce0423	1.093e-67	237.0	COG1807@1|root,COG1807@2|Bacteria,1R4F0@1224|Proteobacteria	1224|Proteobacteria	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HKD2_k127_2557532_0	1192034.CAP_2877	8.414e-240	749.0	COG0504@1|root,COG0504@2|Bacteria,1MUIT@1224|Proteobacteria,42MEU@68525|delta/epsilon subdivisions,2WJ0F@28221|Deltaproteobacteria,2YTT7@29|Myxococcales	28221|Deltaproteobacteria	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_1276	CTP_synth_N,GATase
HKD2_k127_2557532_1	1254432.SCE1572_07590	4.94e-32	144.0	COG0454@1|root,COG0456@2|Bacteria,1RH0C@1224|Proteobacteria,433BT@68525|delta/epsilon subdivisions,2X7UC@28221|Deltaproteobacteria,2YVJS@29|Myxococcales	28221|Deltaproteobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HKD2_k127_255956_5	502025.Hoch_4783	8.173e-28	123.0	COG1024@1|root,COG1024@2|Bacteria,1N2V7@1224|Proteobacteria,42UXR@68525|delta/epsilon subdivisions,2WQCT@28221|Deltaproteobacteria,2Z1AY@29|Myxococcales	28221|Deltaproteobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	4.2.1.17	ko:K01692	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
HKD2_k127_255956_2	1120792.JAFV01000001_gene468	5.845e-56	199.0	COG0346@1|root,COG0346@2|Bacteria,1RCYX@1224|Proteobacteria,2U7A8@28211|Alphaproteobacteria,36Y4D@31993|Methylocystaceae	28211|Alphaproteobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	gloA	GO:0003674,GO:0003824,GO:0004462,GO:0006518,GO:0006575,GO:0006749,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016829,GO:0016846,GO:0034641,GO:0043603,GO:0044237,GO:0051186,GO:0071704,GO:1901564	4.4.1.5	ko:K01759	ko00620,map00620	-	R02530	RC00004,RC00740	ko00000,ko00001,ko01000	-	-	-	Glyoxalase
HKD2_k127_255956_3	335659.S23_25090	2.654e-46	188.0	COG2020@1|root,COG2020@2|Bacteria,1MWU6@1224|Proteobacteria,2TU80@28211|Alphaproteobacteria,3JQR6@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	O	methyltransferase activity	-	-	2.1.1.334	ko:K21310	ko00920,map00920	-	R11546	RC02653	ko00000,ko00001,ko01000	-	-	-	NnrU,PEMT
HKD2_k127_255956_1	543632.JOJL01000006_gene9642	1.404e-64	237.0	COG2021@1|root,COG2197@1|root,COG2021@2|Bacteria,COG2197@2|Bacteria,2GN4Z@201174|Actinobacteria	201174|Actinobacteria	K	luxR family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_4,Abhydrolase_6,GerE
HKD2_k127_255956_0	1206732.BAGD01000085_gene3791	1.326e-83	314.0	COG3831@1|root,COG3831@2|Bacteria,2HIEQ@201174|Actinobacteria,4FZVQ@85025|Nocardiaceae	201174|Actinobacteria	S	Domain of unknown function (DUF4132)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4132
HKD2_k127_255956_4	1121342.AUCO01000017_gene2851	4.251e-30	122.0	COG1953@1|root,COG1953@2|Bacteria,1TS5W@1239|Firmicutes,247WK@186801|Clostridia,36VS3@31979|Clostridiaceae	186801|Clostridia	FH	PFAM Permease for cytosine purines, uracil, thiamine, allantoin	pucI	-	-	ko:K03457	-	-	-	-	ko00000	2.A.39	-	-	Transp_cyt_pur
HKD2_k127_2560694_0	448385.sce2921	0.0	1225.0	COG0457@1|root,COG2956@1|root,COG3071@1|root,COG0457@2|Bacteria,COG2956@2|Bacteria,COG3071@2|Bacteria,1MVIW@1224|Proteobacteria,437VP@68525|delta/epsilon subdivisions,2WWNT@28221|Deltaproteobacteria,2YUC4@29|Myxococcales	28221|Deltaproteobacteria	G	repeat protein	agmK	-	-	-	-	-	-	-	-	-	-	-	TPR_19,TPR_6,TPR_7,TPR_8
HKD2_k127_2564399_3	570268.ANBB01000045_gene1142	4.208e-06	59.0	COG4260@1|root,COG4260@2|Bacteria,2HUEV@201174|Actinobacteria,4EP9H@85012|Streptosporangiales	201174|Actinobacteria	S	SPFH domain-Band 7 family	-	-	-	-	-	-	-	-	-	-	-	-	Band_7_1,DUF4339,SHOCT
HKD2_k127_2564399_4	6326.BUX.s00036.47	5.266e-05	55.0	COG0500@1|root,2S7J0@2759|Eukaryota,3A4KV@33154|Opisthokonta,3C028@33208|Metazoa,3D8WP@33213|Bilateria,40G5G@6231|Nematoda,1KWA3@119089|Chromadorea	33208|Metazoa	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
HKD2_k127_2564399_2	1192034.CAP_2118	4.518e-34	149.0	COG2010@1|root,COG2010@2|Bacteria,1PD95@1224|Proteobacteria,43E5K@68525|delta/epsilon subdivisions,2WZSQ@28221|Deltaproteobacteria,2Z2P1@29|Myxococcales	28221|Deltaproteobacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2564399_1	439235.Dalk_2504	3.49e-65	240.0	COG0500@1|root,COG2835@1|root,COG2226@2|Bacteria,COG2835@2|Bacteria,1NWX3@1224|Proteobacteria,42URB@68525|delta/epsilon subdivisions,2WQ85@28221|Deltaproteobacteria,2MKYQ@213118|Desulfobacterales	28221|Deltaproteobacteria	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
HKD2_k127_2564399_0	448385.sce8599	2.352e-104	347.0	2A4BQ@1|root,30SXD@2|Bacteria,1PCFN@1224|Proteobacteria,438EV@68525|delta/epsilon subdivisions,2WYPE@28221|Deltaproteobacteria,2YWSY@29|Myxococcales	28221|Deltaproteobacteria	S	IgGFc binding protein	-	-	-	-	-	-	-	-	-	-	-	-	IgGFc_binding
HKD2_k127_2576627_1	926550.CLDAP_25590	4.677e-87	304.0	COG1572@1|root,COG1572@2|Bacteria	2|Bacteria	NU	bacterial-type flagellum-dependent cell motility	-	-	-	-	-	-	-	-	-	-	-	-	BatA,CARDB,DUF3367,DUF4091,DUF4159
HKD2_k127_2576627_0	1254432.SCE1572_20425	4.801e-145	486.0	COG0823@1|root,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,PA14,PD40,PKD
HKD2_k127_2578503_1	426117.M446_0943	4.034e-70	248.0	COG0463@1|root,COG0463@2|Bacteria,1QWI9@1224|Proteobacteria,2TYKB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	COG0463 Glycosyltransferases involved in cell wall biogenesis	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HKD2_k127_2578503_0	1122609.AUGT01000009_gene3160	5.342e-140	447.0	COG0451@1|root,COG0451@2|Bacteria,2I2EG@201174|Actinobacteria,4DP7C@85009|Propionibacteriales	201174|Actinobacteria	M	RmlD substrate binding domain	-	-	4.2.1.46,5.1.3.2	ko:K01710,ko:K01784	ko00052,ko00520,ko00521,ko00523,ko00525,ko01055,ko01100,ko01130,map00052,map00520,map00521,map00523,map00525,map01055,map01100,map01130	M00361,M00362,M00632,M00793	R00291,R02984,R06513	RC00289,RC00402	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
HKD2_k127_2580478_3	61622.XP_010354851.1	1.643e-88	295.0	COG0183@1|root,KOG1391@2759|Eukaryota,39QWG@33154|Opisthokonta,3BAQ0@33208|Metazoa,3CS5N@33213|Bilateria,481QU@7711|Chordata,491BS@7742|Vertebrata,3JCE3@40674|Mammalia,35HQ9@314146|Euarchontoglires,4M5J6@9443|Primates,362NT@314294|Cercopithecoidea	33208|Metazoa	I	Belongs to the thiolase family	ACAA2	GO:0001666,GO:0003674,GO:0003824,GO:0003988,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0006066,GO:0006082,GO:0006084,GO:0006139,GO:0006163,GO:0006629,GO:0006631,GO:0006635,GO:0006637,GO:0006694,GO:0006695,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006839,GO:0006915,GO:0006950,GO:0006996,GO:0007005,GO:0007006,GO:0008150,GO:0008152,GO:0008202,GO:0008203,GO:0008219,GO:0008610,GO:0008637,GO:0009056,GO:0009058,GO:0009062,GO:0009117,GO:0009150,GO:0009259,GO:0009628,GO:0009966,GO:0009968,GO:0009987,GO:0010639,GO:0010646,GO:0010648,GO:0010821,GO:0010823,GO:0010941,GO:0012501,GO:0016042,GO:0016043,GO:0016054,GO:0016125,GO:0016126,GO:0016408,GO:0016740,GO:0016746,GO:0016747,GO:0019395,GO:0019637,GO:0019693,GO:0019752,GO:0023051,GO:0023057,GO:0030258,GO:0031974,GO:0032787,GO:0032879,GO:0033043,GO:0033554,GO:0033865,GO:0033875,GO:0034032,GO:0034440,GO:0034641,GO:0035383,GO:0035795,GO:0036293,GO:0036294,GO:0042221,GO:0042981,GO:0043066,GO:0043067,GO:0043069,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044283,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046165,GO:0046395,GO:0046483,GO:0046902,GO:0048519,GO:0048523,GO:0048583,GO:0048585,GO:0050789,GO:0050794,GO:0050896,GO:0051049,GO:0051051,GO:0051128,GO:0051129,GO:0051179,GO:0051186,GO:0051234,GO:0051716,GO:0055086,GO:0055114,GO:0060548,GO:0061024,GO:0065007,GO:0065008,GO:0070013,GO:0070482,GO:0070887,GO:0071453,GO:0071456,GO:0071704,GO:0071840,GO:0072329,GO:0072521,GO:0090559,GO:1901028,GO:1901029,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901575,GO:1901576,GO:1901615,GO:1901617,GO:1902108,GO:1902109,GO:1902652,GO:1902653,GO:1905709,GO:2001233,GO:2001234	2.3.1.16,2.3.1.254	ko:K07508,ko:K17972	ko00062,ko00071,ko00280,ko01100,ko01110,ko01130,ko01212,map00062,map00071,map00280,map01100,map01110,map01130,map01212	M00085,M00087	R00391,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747	RC00004,RC00326,RC00405,RC01702	ko00000,ko00001,ko00002,ko01000,ko03029	-	-	-	Thiolase_C,Thiolase_N
HKD2_k127_2580478_1	448385.sce7214	5.423e-107	366.0	COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,439XM@68525|delta/epsilon subdivisions,2X1UY@28221|Deltaproteobacteria,2Z0MH@29|Myxococcales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
HKD2_k127_2580478_5	448385.sce7215	1.434e-60	240.0	COG0642@1|root,COG2205@2|Bacteria	448385.sce7215|-	T	PhoQ Sensor	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2580478_4	1123354.AUDR01000013_gene809	2.472e-88	323.0	COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,2VI2V@28216|Betaproteobacteria,1KS54@119069|Hydrogenophilales	119069|Hydrogenophilales	E	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia	trpE	-	4.1.3.27	ko:K01657	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
HKD2_k127_2580478_0	448385.sce6192	2.603e-193	611.0	COG3246@1|root,COG3246@2|Bacteria,1MZTP@1224|Proteobacteria,42QYC@68525|delta/epsilon subdivisions,2WN66@28221|Deltaproteobacteria,2Z2W3@29|Myxococcales	28221|Deltaproteobacteria	S	Pfam:Kce	-	-	2.3.1.247	ko:K18013	ko00310,map00310	-	R10564	RC02728,RC03199	ko00000,ko00001,ko01000	-	-	-	4HBT,BKACE
HKD2_k127_2580478_2	448385.sce0675	1.251e-89	323.0	COG2124@1|root,COG2124@2|Bacteria,1MY5H@1224|Proteobacteria,437UU@68525|delta/epsilon subdivisions,2WYPC@28221|Deltaproteobacteria,2YU77@29|Myxococcales	28221|Deltaproteobacteria	C	Cytochrome P450	-	-	-	-	-	-	-	-	-	-	-	-	p450
HKD2_k127_2599532_4	1386969.AWTB01000007_gene2588	3.758e-09	65.0	COG0204@1|root,COG0204@2|Bacteria,2GNBB@201174|Actinobacteria,4GAQ2@85026|Gordoniaceae	201174|Actinobacteria	I	Diacylglycerol acyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acyltransferase
HKD2_k127_2599532_0	1254432.SCE1572_39735	6.23e-99	336.0	COG0438@1|root,COG0438@2|Bacteria,1Q3IF@1224|Proteobacteria,43794@68525|delta/epsilon subdivisions,2WTY0@28221|Deltaproteobacteria,2YWM7@29|Myxococcales	28221|Deltaproteobacteria	M	Glycosyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
HKD2_k127_2599532_1	1123368.AUIS01000001_gene1885	2.506e-78	283.0	COG0510@1|root,COG0510@2|Bacteria,1NUSY@1224|Proteobacteria	1224|Proteobacteria	M	thiamine kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2599532_3	504832.OCAR_7174	4.988e-14	84.0	2CIPC@1|root,2Z9HB@2|Bacteria,1R3W8@1224|Proteobacteria,2TST7@28211|Alphaproteobacteria,3JT48@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Glycosyltransferase family 87	-	-	-	-	-	-	-	-	-	-	-	-	GT87
HKD2_k127_2599532_2	670487.Ocepr_1481	2.497e-70	265.0	2DB7V@1|root,2Z7NX@2|Bacteria,1WM7S@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2606620_0	1408444.JHYC01000037_gene1889	1.663e-54	212.0	COG2706@1|root,COG2706@2|Bacteria,1RB38@1224|Proteobacteria,1SNAF@1236|Gammaproteobacteria,1JE2M@118969|Legionellales	118969|Legionellales	G	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2606620_2	448385.sce3943	1.964e-38	158.0	COG3628@1|root,COG3628@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2606620_1	1192034.CAP_2118	2.329e-48	184.0	COG2010@1|root,COG2010@2|Bacteria,1PD95@1224|Proteobacteria,43E5K@68525|delta/epsilon subdivisions,2WZSQ@28221|Deltaproteobacteria,2Z2P1@29|Myxococcales	28221|Deltaproteobacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2606620_3	1192034.CAP_3562	0.0002416	44.0	COG0810@1|root,COG0810@2|Bacteria,1QARZ@1224|Proteobacteria,4359H@68525|delta/epsilon subdivisions,2WZKN@28221|Deltaproteobacteria,2Z2BQ@29|Myxococcales	28221|Deltaproteobacteria	M	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2608165_2	290397.Adeh_3956	6.439e-08	56.0	2A9VF@1|root,30Z3B@2|Bacteria,1PKZS@1224|Proteobacteria,435JG@68525|delta/epsilon subdivisions,2WZXJ@28221|Deltaproteobacteria,2Z0YG@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2608165_0	383372.Rcas_0264	3.275e-70	257.0	COG5184@1|root,COG5184@2|Bacteria,2G8WU@200795|Chloroflexi,3765G@32061|Chloroflexia	32061|Chloroflexia	DZ	PFAM regulator of chromosome condensation, RCC1	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2608165_1	1192034.CAP_2668	2.321e-38	148.0	COG1470@1|root,COG1470@2|Bacteria,1QZIJ@1224|Proteobacteria,43CK1@68525|delta/epsilon subdivisions,2X7UG@28221|Deltaproteobacteria,2YY6W@29|Myxococcales	28221|Deltaproteobacteria	S	PEGA domain	-	-	-	-	-	-	-	-	-	-	-	-	PEGA
HKD2_k127_2608795_1	448385.sce0945	4.051e-127	439.0	COG0741@1|root,COG1729@1|root,COG0741@2|Bacteria,COG1729@2|Bacteria,1MW2T@1224|Proteobacteria,42M1M@68525|delta/epsilon subdivisions,2WPBN@28221|Deltaproteobacteria,2Z2ZM@29|Myxococcales	28221|Deltaproteobacteria	M	Transglycosylase SLT domain	mltC	-	-	ko:K08306,ko:K08309	-	-	-	-	ko00000,ko01000,ko01011	-	GH23	-	DUF3393,SLT,TPR_6
HKD2_k127_2608795_0	443143.GM18_1724	9.327e-184	586.0	COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,42MGK@68525|delta/epsilon subdivisions,2WJQH@28221|Deltaproteobacteria,43TR2@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	PFAM Carbamoyl-phosphate synthase L chain ATP-binding	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
HKD2_k127_2614238_0	391625.PPSIR1_18075	1.174e-219	705.0	COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,42MER@68525|delta/epsilon subdivisions,2WIYV@28221|Deltaproteobacteria,2YW7P@29|Myxococcales	28221|Deltaproteobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding	-	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
HKD2_k127_2614238_1	1192034.CAP_1621	8.793e-122	406.0	COG0119@1|root,COG2080@1|root,COG0119@2|Bacteria,COG2080@2|Bacteria,1MUNQ@1224|Proteobacteria,42MSP@68525|delta/epsilon subdivisions,2WIUZ@28221|Deltaproteobacteria,2YTZB@29|Myxococcales	28221|Deltaproteobacteria	E	synthase homocitrate synthase family	-	-	-	-	-	-	-	-	-	-	-	-	HMGL-like
HKD2_k127_2614238_4	398767.Glov_2410	0.0005955	49.0	COG2068@1|root,COG2068@2|Bacteria,1RAAE@1224|Proteobacteria,42QNZ@68525|delta/epsilon subdivisions,2WMYX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	SMART Metal-dependent phosphohydrolase, HD region	-	-	2.7.7.76	ko:K07141	ko00790,map00790	-	R11582	-	ko00000,ko00001,ko01000	-	-	-	HD,NTP_transf_3
HKD2_k127_2614238_2	1187851.A33M_3193	8.015e-97	328.0	COG1063@1|root,COG1063@2|Bacteria,1QTU5@1224|Proteobacteria,2TW9Q@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	yphC	-	1.1.1.368	ko:K07538	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00541	R05581	RC00850	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_N_assoc,ADH_zinc_N
HKD2_k127_2614238_3	404380.Gbem_1443	6.457e-54	196.0	COG1024@1|root,COG1024@2|Bacteria,1QY95@1224|Proteobacteria,42N5K@68525|delta/epsilon subdivisions,2WK1G@28221|Deltaproteobacteria,43TNB@69541|Desulfuromonadales	28221|Deltaproteobacteria	I	Enoyl-CoA hydratase/isomerase	bamA	GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009150,GO:0009154,GO:0009166,GO:0009259,GO:0009261,GO:0009987,GO:0016787,GO:0016822,GO:0016823,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0033865,GO:0033869,GO:0033875,GO:0034031,GO:0034032,GO:0034034,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035383,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044273,GO:0044281,GO:0044283,GO:0046434,GO:0046483,GO:0046700,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901787,GO:1901788	3.7.1.21	ko:K07539	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00541	R05593,R05594,R10696	RC01430,RC01431,RC03237	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
HKD2_k127_2617292_1	1192034.CAP_4577	9.371e-78	271.0	COG1240@1|root,COG1716@1|root,COG1240@2|Bacteria,COG1716@2|Bacteria	2|Bacteria	T	histone H2A K63-linked ubiquitination	bchD	-	6.6.1.1	ko:K03404,ko:K07114	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R03877	RC01012	ko00000,ko00001,ko01000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VWA,VWA_2
HKD2_k127_2617292_4	1254432.SCE1572_15065	1.624e-25	122.0	COG1240@1|root,COG1716@1|root,COG1240@2|Bacteria,COG1716@2|Bacteria	2|Bacteria	T	histone H2A K63-linked ubiquitination	bchD	-	6.6.1.1	ko:K03404,ko:K07114	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R03877	RC01012	ko00000,ko00001,ko01000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VWA,VWA_2
HKD2_k127_2617292_7	324602.Caur_1442	4e-15	81.0	COG2203@1|root,COG2204@1|root,COG4191@1|root,COG2203@2|Bacteria,COG2204@2|Bacteria,COG4191@2|Bacteria,2G7Y4@200795|Chloroflexi,3772K@32061|Chloroflexia	32061|Chloroflexia	T	histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,Response_reg
HKD2_k127_2617292_2	420662.Mpe_A1006	2.835e-61	216.0	COG2044@1|root,COG2044@2|Bacteria,1RGAZ@1224|Proteobacteria,2VYDA@28216|Betaproteobacteria	28216|Betaproteobacteria	S	DsrE/DsrF-like family	-	-	-	-	-	-	-	-	-	-	-	-	DrsE
HKD2_k127_2617292_0	420662.Mpe_A1005	4.788e-138	446.0	COG2207@1|root,COG2207@2|Bacteria,1N0FA@1224|Proteobacteria,2VKR0@28216|Betaproteobacteria,1KPH2@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	Cupin	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_6,HTH_18
HKD2_k127_2617292_3	1192034.CAP_2038	1.28e-58	232.0	2A4SI@1|root,30TDY@2|Bacteria,1PD6V@1224|Proteobacteria,435EQ@68525|delta/epsilon subdivisions,2X98Q@28221|Deltaproteobacteria,2Z2N2@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2617292_6	1116232.AHBF01000113_gene4544	4.65e-24	108.0	COG4638@1|root,COG4638@2|Bacteria,2IA3C@201174|Actinobacteria	201174|Actinobacteria	P	Rieske 2Fe-2S	-	-	-	-	-	-	-	-	-	-	-	-	Rieske
HKD2_k127_2619293_3	1254432.SCE1572_47495	5.752e-106	351.0	COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,42M7M@68525|delta/epsilon subdivisions,2WJ9X@28221|Deltaproteobacteria,2YU54@29|Myxococcales	28221|Deltaproteobacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
HKD2_k127_2619293_4	1449347.JQLN01000006_gene3165	3.235e-05	55.0	COG3291@1|root,COG3291@2|Bacteria,2H2CR@201174|Actinobacteria,2M467@2063|Kitasatospora	201174|Actinobacteria	S	Pkd domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2619293_0	448385.sce8271	3.041e-239	759.0	COG1305@1|root,COG1305@2|Bacteria,1MWCE@1224|Proteobacteria,42NIZ@68525|delta/epsilon subdivisions,2WM5U@28221|Deltaproteobacteria,2Z315@29|Myxococcales	28221|Deltaproteobacteria	E	Domain of unknown function (DUF3488)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3488,DUF4129,Transglut_core
HKD2_k127_2619293_2	1254432.SCE1572_48295	7.838e-140	453.0	COG1721@1|root,COG1721@2|Bacteria,1N8IQ@1224|Proteobacteria,42S2K@68525|delta/epsilon subdivisions,2WNA2@28221|Deltaproteobacteria,2YVGE@29|Myxococcales	28221|Deltaproteobacteria	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
HKD2_k127_2619293_1	1254432.SCE1572_48300	1.492e-147	471.0	COG0714@1|root,COG0714@2|Bacteria,1MUFN@1224|Proteobacteria,42NCX@68525|delta/epsilon subdivisions,2WIYY@28221|Deltaproteobacteria,2YWP3@29|Myxococcales	28221|Deltaproteobacteria	S	ATPase family associated with various cellular activities (AAA)	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
HKD2_k127_2632478_0	448385.sce8150	2.266e-27	120.0	COG2197@1|root,COG2199@1|root,COG2197@2|Bacteria,COG3706@2|Bacteria	2|Bacteria	T	GGDEF domain	cheY	-	3.1.1.61,3.5.1.44	ko:K03412,ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheX,HATPase_c,HDOD,HisKA,Response_reg
HKD2_k127_2632478_1	536019.Mesop_3032	3.315e-15	88.0	COG4552@1|root,COG4552@2|Bacteria,1NBTH@1224|Proteobacteria	1224|Proteobacteria	S	Sterol carrier protein domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_9,SCP2_2
HKD2_k127_2632478_2	448385.sce1096	1.064e-05	58.0	COG3119@1|root,COG3119@2|Bacteria,1QZHU@1224|Proteobacteria,42PUM@68525|delta/epsilon subdivisions,2X7T5@28221|Deltaproteobacteria,2Z00V@29|Myxococcales	28221|Deltaproteobacteria	P	Sulfatase	-	-	3.1.6.6	ko:K01133	-	-	-	-	ko00000,ko01000	-	-	-	Cu-binding_MopE,Sulfatase
HKD2_k127_2644190_2	448385.sce4808	5.805e-24	113.0	COG1633@1|root,COG1633@2|Bacteria,1Q2YM@1224|Proteobacteria,438N5@68525|delta/epsilon subdivisions,2X3W7@28221|Deltaproteobacteria,2YXBD@29|Myxococcales	28221|Deltaproteobacteria	S	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2644190_0	1254432.SCE1572_00985	3.943e-110	392.0	COG3899@1|root,COG3899@2|Bacteria	2|Bacteria	T	PFAM Protein kinase domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GerE
HKD2_k127_2644190_1	518766.Rmar_2430	1.54e-54	203.0	COG2010@1|root,COG2010@2|Bacteria,4NHQV@976|Bacteroidetes	976|Bacteroidetes	C	PFAM Cytochrome C	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,Cytochrome_CBB3
HKD2_k127_2646420_2	448385.sce4262	5.93e-106	356.0	COG0457@1|root,COG0457@2|Bacteria,1QTJQ@1224|Proteobacteria,4311V@68525|delta/epsilon subdivisions	1224|Proteobacteria	U	cell septum assembly	-	-	-	-	-	-	-	-	-	-	-	-	TPR_8
HKD2_k127_2646420_3	448385.sce4263	2.215e-96	346.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,42Q67@68525|delta/epsilon subdivisions,2WKZ1@28221|Deltaproteobacteria	68525|delta/epsilon subdivisions	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HKD2_k127_2646420_7	448385.sce8617	7.62e-44	178.0	COG1413@1|root,COG1413@2|Bacteria	2|Bacteria	C	deoxyhypusine monooxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2646420_4	1254432.SCE1572_46600	1.486e-81	281.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25,Methyltransf_31
HKD2_k127_2646420_5	448385.sce8703	4.638e-65	248.0	COG0457@1|root,COG0457@2|Bacteria,1QQ0R@1224|Proteobacteria,433U8@68525|delta/epsilon subdivisions,2X3GZ@28221|Deltaproteobacteria,2YW20@29|Myxococcales	28221|Deltaproteobacteria	S	zinc-ribbon domain	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,zinc_ribbon_4
HKD2_k127_2646420_1	1254432.SCE1572_49925	3.361e-147	494.0	COG0616@1|root,COG0616@2|Bacteria,1MUXE@1224|Proteobacteria,4347K@68525|delta/epsilon subdivisions,2X42E@28221|Deltaproteobacteria,2YY2K@29|Myxococcales	28221|Deltaproteobacteria	OU	Peptidase family S49	-	-	-	ko:K04773	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S49
HKD2_k127_2646420_0	448385.sce8705	3.226e-267	909.0	COG5164@1|root,COG5164@2|Bacteria	2|Bacteria	K	cell wall organization	-	-	2.7.11.1	ko:K14949	ko05152,map05152	-	-	-	ko00000,ko00001,ko01000,ko01001	-	-	-	Pkinase
HKD2_k127_2647117_0	1192034.CAP_1698	7.186e-270	841.0	COG0028@1|root,COG0028@2|Bacteria,1MXDW@1224|Proteobacteria,42NVI@68525|delta/epsilon subdivisions,2WJTD@28221|Deltaproteobacteria,2YTYS@29|Myxococcales	28221|Deltaproteobacteria	EH	Belongs to the TPP enzyme family	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
HKD2_k127_2647117_4	309801.trd_0152	5.025e-16	81.0	2EQM1@1|root,33I6Z@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF2892)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2892
HKD2_k127_2647117_3	887062.HGR_15299	1.039e-30	128.0	COG2320@1|root,COG2320@2|Bacteria,1RH46@1224|Proteobacteria,2VWUR@28216|Betaproteobacteria,4AG2X@80864|Comamonadaceae	28216|Betaproteobacteria	S	GrpB protein	-	-	-	-	-	-	-	-	-	-	-	-	GrpB
HKD2_k127_2647117_2	937777.Deipe_0245	3.221e-77	267.0	COG1028@1|root,COG1028@2|Bacteria,1WM2Z@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HKD2_k127_2647117_1	502025.Hoch_5711	3.284e-113	388.0	COG1193@1|root,COG1193@2|Bacteria,1QUJI@1224|Proteobacteria,42P7P@68525|delta/epsilon subdivisions,2WK5H@28221|Deltaproteobacteria,2YTYQ@29|Myxococcales	28221|Deltaproteobacteria	L	Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity	mutS2	-	-	ko:K07456	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_V,Smr
HKD2_k127_2649472_3	1144275.COCOR_05266	5.576e-36	144.0	COG0110@1|root,COG0110@2|Bacteria	2|Bacteria	S	O-acyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep
HKD2_k127_2649472_1	1144275.COCOR_05267	6.971e-39	157.0	COG0110@1|root,COG0110@2|Bacteria	2|Bacteria	S	O-acyltransferase activity	wcaF	GO:0003674,GO:0003824,GO:0008374,GO:0016740,GO:0016746,GO:0016747	2.3.1.79	ko:K00661,ko:K03818	-	-	-	-	ko00000,ko01000	-	-	-	Hexapep,Hexapep_2
HKD2_k127_2649472_2	1192034.CAP_2183	1.968e-38	147.0	COG0261@1|root,COG0261@2|Bacteria,1MZEW@1224|Proteobacteria,42SGM@68525|delta/epsilon subdivisions,2WQ3I@28221|Deltaproteobacteria,2YVHC@29|Myxococcales	28221|Deltaproteobacteria	J	This protein binds to 23S rRNA in the presence of protein L20	rplU	GO:0003674,GO:0003735,GO:0005198	-	ko:K02888	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L21p
HKD2_k127_2649472_4	1304885.AUEY01000017_gene3742	8.739e-32	127.0	COG0211@1|root,COG0211@2|Bacteria,1MZGH@1224|Proteobacteria,42THK@68525|delta/epsilon subdivisions,2WQ2U@28221|Deltaproteobacteria,2MKMM@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Belongs to the bacterial ribosomal protein bL27 family	rpmA	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02899	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27
HKD2_k127_2649472_0	1254432.SCE1572_45520	6.775e-79	278.0	COG0561@1|root,COG0561@2|Bacteria	2|Bacteria	Q	phosphatase activity	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_3
HKD2_k127_2650249_1	1192034.CAP_7912	3.317e-97	325.0	COG2030@1|root,COG2030@2|Bacteria,1QXU8@1224|Proteobacteria,43C6S@68525|delta/epsilon subdivisions,2X7GZ@28221|Deltaproteobacteria,2YW6B@29|Myxococcales	28221|Deltaproteobacteria	I	MaoC like domain	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydratas
HKD2_k127_2650249_0	1192034.CAP_5365	2.444e-100	331.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,42MSR@68525|delta/epsilon subdivisions,2WIXG@28221|Deltaproteobacteria,2Z30V@29|Myxococcales	28221|Deltaproteobacteria	I	Thiolase, C-terminal domain	-	-	2.3.1.16,2.3.1.9	ko:K00626,ko:K07508	ko00062,ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00062,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00085,M00087,M00088,M00095,M00373,M00374,M00375	R00238,R00391,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747	RC00004,RC00326,RC00405,RC01702	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
HKD2_k127_2660782_2	1254432.SCE1572_17630	1.986e-104	345.0	COG2185@1|root,COG2185@2|Bacteria,1R6CI@1224|Proteobacteria,43CUR@68525|delta/epsilon subdivisions,2X82G@28221|Deltaproteobacteria,2YYB5@29|Myxococcales	28221|Deltaproteobacteria	I	Dimerisation domain of d-ornithine 4,5-aminomutase	-	-	5.4.3.3	ko:K18011	ko00310,map00310	-	R02852,R03275	RC00719	ko00000,ko00001,ko01000	-	-	-	B12-binding,OAM_dimer
HKD2_k127_2660782_0	1192034.CAP_0149	2.106e-246	769.0	COG0274@1|root,COG0274@2|Bacteria,1R45J@1224|Proteobacteria,438PK@68525|delta/epsilon subdivisions,2X8TQ@28221|Deltaproteobacteria,2YXFJ@29|Myxococcales	28221|Deltaproteobacteria	F	D-Lysine 5,6-aminomutase TIM-barrel domain of alpha subunit	kamD	-	5.4.3.3	ko:K01844	ko00310,map00310	-	R02852,R03275	RC00719	ko00000,ko00001,ko01000	-	-	-	Lys-AminoMut_A
HKD2_k127_2660782_3	448385.sce8041	2.194e-70	263.0	COG1277@1|root,COG1277@2|Bacteria,1RM0H@1224|Proteobacteria,42T8A@68525|delta/epsilon subdivisions,2WPQJ@28221|Deltaproteobacteria,2YVVY@29|Myxococcales	28221|Deltaproteobacteria	S	ABC-type transport system involved in multi-copper enzyme maturation permease component	pilI	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane_2,ABC2_membrane_4
HKD2_k127_2660782_1	448385.sce2057	1.124e-107	357.0	COG1597@1|root,COG1597@2|Bacteria,1PV0P@1224|Proteobacteria,42XZR@68525|delta/epsilon subdivisions,2WTF1@28221|Deltaproteobacteria,2YVY3@29|Myxococcales	28221|Deltaproteobacteria	I	Diacylglycerol kinase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	DAGK_cat
HKD2_k127_2663414_0	1267535.KB906767_gene2871	2.365e-260	818.0	COG0474@1|root,COG0474@2|Bacteria,3Y3ZX@57723|Acidobacteria,2JMFS@204432|Acidobacteriia	204432|Acidobacteriia	P	TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.2	ko:K01531	-	-	-	-	ko00000,ko01000	3.A.3.4	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
HKD2_k127_2663414_6	1254432.SCE1572_36805	4.979e-40	158.0	COG0071@1|root,COG0071@2|Bacteria,1N7C7@1224|Proteobacteria,42U0T@68525|delta/epsilon subdivisions,2WNF6@28221|Deltaproteobacteria,2Z32K@29|Myxococcales	28221|Deltaproteobacteria	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
HKD2_k127_2663414_4	1120972.AUMH01000007_gene1721	4.593e-51	208.0	COG0515@1|root,COG0515@2|Bacteria,1TP3F@1239|Firmicutes,4H9KD@91061|Bacilli,277VY@186823|Alicyclobacillaceae	91061|Bacilli	KLT	Serine/Threonine protein kinases, catalytic domain	prkC	GO:0002237,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005488,GO:0005539,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009605,GO:0009607,GO:0009617,GO:0009719,GO:0009847,GO:0009987,GO:0010033,GO:0010243,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019538,GO:0023052,GO:0032494,GO:0032502,GO:0036211,GO:0042221,GO:0042834,GO:0043170,GO:0043207,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051704,GO:0051707,GO:0051716,GO:0065007,GO:0070887,GO:0071216,GO:0071219,GO:0071224,GO:0071310,GO:0071417,GO:0071495,GO:0071704,GO:0071944,GO:0097367,GO:0140096,GO:1901564,GO:1901698,GO:1901699,GO:1901700,GO:1901701	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
HKD2_k127_2663414_5	314285.KT71_14044	5.278e-51	195.0	COG1028@1|root,COG1028@2|Bacteria,1MUCH@1224|Proteobacteria,1RWTA@1236|Gammaproteobacteria,1J94U@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	IQ	Fungal family of unknown function (DUF1776)	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HKD2_k127_2663414_2	391625.PPSIR1_17215	1.129e-97	331.0	2DBF7@1|root,2Z8X0@2|Bacteria,1QXU4@1224|Proteobacteria,42YFE@68525|delta/epsilon subdivisions,2WTQD@28221|Deltaproteobacteria,2YUC6@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Chlam_PMP
HKD2_k127_2663414_1	382464.ABSI01000011_gene2734	1.343e-104	362.0	COG0038@1|root,COG0038@2|Bacteria,46U35@74201|Verrucomicrobia,2IU1K@203494|Verrucomicrobiae	203494|Verrucomicrobiae	P	Voltage gated chloride channel	-	-	-	-	-	-	-	-	-	-	-	-	CBS,Voltage_CLC
HKD2_k127_2663414_3	483219.LILAB_14555	7.088e-53	196.0	COG1073@1|root,COG1073@2|Bacteria,1RIWI@1224|Proteobacteria,42TGK@68525|delta/epsilon subdivisions,2WNGS@28221|Deltaproteobacteria,2YVXN@29|Myxococcales	28221|Deltaproteobacteria	S	of the alpha beta superfamily	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Abhydrolase_1,Hydrolase_4
HKD2_k127_2663414_7	1121945.ATXS01000001_gene2311	1.664e-25	107.0	COG0535@1|root,arCOG00938@2157|Archaea,2Y8D0@28890|Euryarchaeota,23S38@183963|Halobacteria	183963|Halobacteria	S	Fe-S oxidoreductases	pqqE	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM
HKD2_k127_2666100_4	748280.NH8B_3602	6.654e-42	155.0	COG2326@1|root,COG2326@2|Bacteria,1MVE2@1224|Proteobacteria,2VGZV@28216|Betaproteobacteria,2KPNZ@206351|Neisseriales	206351|Neisseriales	S	Polyphosphate kinase 2 (PPK2)	-	-	-	-	-	-	-	-	-	-	-	-	PPK2
HKD2_k127_2666100_2	1192034.CAP_8599	9.379e-70	240.0	COG2050@1|root,COG2050@2|Bacteria,1N61W@1224|Proteobacteria,42U4S@68525|delta/epsilon subdivisions,2WQWD@28221|Deltaproteobacteria	28221|Deltaproteobacteria	Q	Thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
HKD2_k127_2666100_5	448385.sce4378	4.205e-34	139.0	COG0597@1|root,COG0597@2|Bacteria	2|Bacteria	MU	This protein specifically catalyzes the removal of signal peptides from prolipoproteins	lspA	-	3.4.23.36	ko:K03101	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_A8
HKD2_k127_2666100_3	1122604.JONR01000009_gene2326	1.388e-60	218.0	COG0300@1|root,COG0300@2|Bacteria,1QTV7@1224|Proteobacteria,1T1IA@1236|Gammaproteobacteria,1X73P@135614|Xanthomonadales	135614|Xanthomonadales	S	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HKD2_k127_2666100_1	555088.DealDRAFT_0893	4.144e-85	308.0	COG1073@1|root,COG1073@2|Bacteria,1TSFY@1239|Firmicutes,24ETS@186801|Clostridia	186801|Clostridia	M	COG1073 Hydrolases of the alpha beta superfamily	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	CW_binding_2,Cu_amine_oxidN1,DLH,DUF3887,Hydrolase_4,Peptidase_S9
HKD2_k127_2666100_7	867903.ThesuDRAFT_01151	8.083e-21	103.0	COG5658@1|root,COG5658@2|Bacteria,1VBIT@1239|Firmicutes,24HIG@186801|Clostridia,3WDJQ@538999|Clostridiales incertae sedis	186801|Clostridia	S	SdpI/YhfL protein family	sdpI	-	-	-	-	-	-	-	-	-	-	-	DUF1648,SdpI
HKD2_k127_2666100_6	1278073.MYSTI_01597	5.328e-24	106.0	COG0640@1|root,COG0640@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	sdpR	GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0044212,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	HTH_20,HTH_5
HKD2_k127_2666100_0	448385.sce4311	1.178e-162	518.0	COG1196@1|root,COG1196@2|Bacteria,1R3XQ@1224|Proteobacteria,42YF5@68525|delta/epsilon subdivisions,2WUDV@28221|Deltaproteobacteria,2YUE5@29|Myxococcales	28221|Deltaproteobacteria	D	HAD superfamily (subfamily IG) hydrolase 5'-Nucleotidase	-	-	-	-	-	-	-	-	-	-	-	-	5_nucleotid
HKD2_k127_2666386_6	1192034.CAP_5357	8.98e-81	271.0	COG2256@1|root,COG2256@2|Bacteria,1MUVS@1224|Proteobacteria,42M9X@68525|delta/epsilon subdivisions,2WJ7E@28221|Deltaproteobacteria,2YU66@29|Myxococcales	28221|Deltaproteobacteria	L	AAA C-terminal domain	rarA	-	-	ko:K07478	-	-	-	-	ko00000	-	-	-	AAA,AAA_assoc_2,MgsA_C,RuvB_N
HKD2_k127_2666386_21	1254432.SCE1572_47555	6.42e-26	117.0	COG0457@1|root,COG0457@2|Bacteria,1R0E0@1224|Proteobacteria,43CWG@68525|delta/epsilon subdivisions,2X84H@28221|Deltaproteobacteria,2YW4A@29|Myxococcales	28221|Deltaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2666386_7	448385.sce8180	1.467e-75	259.0	COG0634@1|root,COG0634@2|Bacteria,1NRT8@1224|Proteobacteria,42SNI@68525|delta/epsilon subdivisions,2WPFN@28221|Deltaproteobacteria,2YV3U@29|Myxococcales	28221|Deltaproteobacteria	F	Belongs to the purine pyrimidine phosphoribosyltransferase family	hpt	-	2.4.2.8	ko:K00760	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	-	R00190,R01132,R01229,R02142,R08237,R08238,R08245	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	Pribosyltran
HKD2_k127_2666386_2	1254432.SCE1572_48480	3.699e-184	611.0	COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,1MUKF@1224|Proteobacteria,42N3S@68525|delta/epsilon subdivisions,2WJ5P@28221|Deltaproteobacteria,2YUX0@29|Myxococcales	28221|Deltaproteobacteria	S	DNA internalization-related competence protein ComEC Rec2	-	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Competence,DUF4131,Lactamase_B
HKD2_k127_2666386_22	448385.sce5861	2.274e-25	116.0	2A4YU@1|root,30TKK@2|Bacteria,1PDH1@1224|Proteobacteria,435GP@68525|delta/epsilon subdivisions,2WZU4@28221|Deltaproteobacteria,2Z2RP@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2666386_10	1254432.SCE1572_34880	9.427e-63	222.0	COG1595@1|root,COG1595@2|Bacteria,1R7KF@1224|Proteobacteria,4385W@68525|delta/epsilon subdivisions,2X9YP@28221|Deltaproteobacteria,2YVWM@29|Myxococcales	28221|Deltaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD2_k127_2666386_23	1254432.SCE1572_34875	6.193e-21	99.0	COG3215@1|root,COG3215@2|Bacteria	2|Bacteria	NU	PilZ domain	-	-	-	-	-	-	-	-	-	-	-	-	PilZ,cNMP_binding
HKD2_k127_2666386_19	448385.sce6599	3.331e-28	128.0	COG1633@1|root,COG1633@2|Bacteria,1QA00@1224|Proteobacteria,434PZ@68525|delta/epsilon subdivisions,2X8YV@28221|Deltaproteobacteria,2Z13N@29|Myxococcales	28221|Deltaproteobacteria	S	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2666386_8	1192034.CAP_7887	3.413e-71	248.0	COG0745@1|root,COG0745@2|Bacteria,1MVCB@1224|Proteobacteria,42RGE@68525|delta/epsilon subdivisions,2WNF7@28221|Deltaproteobacteria,2YUAH@29|Myxococcales	28221|Deltaproteobacteria	K	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
HKD2_k127_2666386_14	246197.MXAN_5314	3.043e-46	190.0	COG0642@1|root,COG2205@2|Bacteria,1N9SU@1224|Proteobacteria,43BZY@68525|delta/epsilon subdivisions,2X39W@28221|Deltaproteobacteria,2YV13@29|Myxococcales	28221|Deltaproteobacteria	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
HKD2_k127_2666386_3	448385.sce8329	1.133e-142	472.0	COG1716@1|root,COG1716@2|Bacteria,1Q8QY@1224|Proteobacteria,437GG@68525|delta/epsilon subdivisions,2X2P3@28221|Deltaproteobacteria,2Z08U@29|Myxococcales	28221|Deltaproteobacteria	T	FHA domain	-	-	-	-	-	-	-	-	-	-	-	-	FHA
HKD2_k127_2666386_9	448385.sce8320	1.661e-68	237.0	COG1510@1|root,COG1510@2|Bacteria	2|Bacteria	K	regulation of RNA biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	MarR_2
HKD2_k127_2666386_0	1254432.SCE1572_15110	6.213e-222	711.0	COG1331@1|root,COG1331@2|Bacteria,1MUUT@1224|Proteobacteria,42MP3@68525|delta/epsilon subdivisions,2WJ7Y@28221|Deltaproteobacteria,2YTWV@29|Myxococcales	28221|Deltaproteobacteria	O	Protein of unknown function, DUF255	yyaL	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	GlcNAc_2-epim,Thioredox_DsbH
HKD2_k127_2666386_25	1192034.CAP_1713	2.314e-09	70.0	2AJDU@1|root,2ZJRB@2|Bacteria,1P73H@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2666386_16	588581.Cpap_1196	2.704e-41	168.0	COG2327@1|root,COG2327@2|Bacteria,1US9G@1239|Firmicutes,24YR6@186801|Clostridia	186801|Clostridia	S	Polysaccharide pyruvyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	PS_pyruv_trans
HKD2_k127_2666386_18	909613.UO65_1337	2.762e-35	149.0	2B6W6@1|root,31ZVY@2|Bacteria,2H2VT@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2666386_13	1968.JOEV01000003_gene3218	3.139e-53	199.0	COG1209@1|root,COG1209@2|Bacteria	2|Bacteria	M	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis	-	-	2.7.7.24	ko:K00973,ko:K15257	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	NTP_transferase
HKD2_k127_2666386_5	1461693.ATO10_09273	7.126e-100	357.0	COG0682@1|root,COG0682@2|Bacteria,1R7B3@1224|Proteobacteria	1224|Proteobacteria	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	-	-	-	-	-	-	-	-	-	-	-	-	LGT,PAP2_3,PEMT
HKD2_k127_2666386_17	1461693.ATO10_09278	1.086e-40	173.0	2E03A@1|root,32VS4@2|Bacteria,1N4NZ@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2666386_12	479433.Caci_3568	2.736e-55	202.0	COG1131@1|root,COG1131@2|Bacteria,2GP3F@201174|Actinobacteria	201174|Actinobacteria	V	ABC transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
HKD2_k127_2666386_27	520999.PROVALCAL_03047	2.008e-05	57.0	COG0671@1|root,COG2453@1|root,COG0671@2|Bacteria,COG2453@2|Bacteria,1QSUD@1224|Proteobacteria,1RQAC@1236|Gammaproteobacteria,3Z8F2@586|Providencia	1236|Gammaproteobacteria	IT	Dual specificity phosphatase, catalytic domain protein	ynbD	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	3.1.3.16	ko:K01090	-	-	-	-	ko00000,ko01000	-	-	-	DAGK_cat,DSPc,PAP2_3
HKD2_k127_2666386_4	448385.sce1717	4.441e-131	431.0	COG0617@1|root,COG0617@2|Bacteria,1MVCS@1224|Proteobacteria,42QKZ@68525|delta/epsilon subdivisions,2WJ74@28221|Deltaproteobacteria,2YU8X@29|Myxococcales	28221|Deltaproteobacteria	H	Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control	pcnB	-	2.7.7.19,2.7.7.72	ko:K00970,ko:K00974	ko03013,ko03018,map03013,map03018	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	PolyA_pol,PolyA_pol_RNAbd,PolyA_pol_arg_C
HKD2_k127_2666386_1	1254432.SCE1572_51290	2.289e-221	691.0	COG0443@1|root,COG0443@2|Bacteria,1MVEN@1224|Proteobacteria,42M64@68525|delta/epsilon subdivisions,2WIWS@28221|Deltaproteobacteria,2YUEK@29|Myxococcales	28221|Deltaproteobacteria	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
HKD2_k127_2687919_3	1121468.AUBR01000028_gene1521	3.096e-53	205.0	COG0657@1|root,COG0657@2|Bacteria,1UZ7B@1239|Firmicutes,25B2C@186801|Clostridia	186801|Clostridia	I	Psort location Cytoplasmic, score	-	-	3.1.1.83	ko:K14731	ko00903,ko00930,ko01220,map00903,map00930,map01220	-	R03751,R06390,R06391,R06392,R06393	RC00713,RC00983,RC01505	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_3
HKD2_k127_2687919_1	448385.sce9234	7.471e-77	267.0	COG0231@1|root,COG0231@2|Bacteria,1MW2J@1224|Proteobacteria,42N6H@68525|delta/epsilon subdivisions,2WNG7@28221|Deltaproteobacteria,2YUWK@29|Myxococcales	28221|Deltaproteobacteria	J	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase	efp	GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K02356	-	-	-	-	ko00000,ko03012	-	-	-	EFP,EFP_N,Elong-fact-P_C
HKD2_k127_2687919_7	448385.sce0489	2.48e-08	67.0	COG3866@1|root,COG3866@2|Bacteria	2|Bacteria	G	Pectate lyase	pnlA	-	4.2.2.10	ko:K01732,ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000	-	-	-	Beta_helix,Pec_lyase_C,RicinB_lectin_2
HKD2_k127_2687919_0	1254432.SCE1572_52175	4.068e-83	300.0	COG1729@1|root,COG1729@2|Bacteria,1QXUN@1224|Proteobacteria,43C75@68525|delta/epsilon subdivisions,2X7HE@28221|Deltaproteobacteria,2YXEZ@29|Myxococcales	28221|Deltaproteobacteria	S	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division	-	-	-	-	-	-	-	-	-	-	-	-	TPR_6
HKD2_k127_2687919_8	1120948.KB903220_gene65	1.228e-07	61.0	COG0484@1|root,COG0484@2|Bacteria,2GK69@201174|Actinobacteria,4DZJH@85010|Pseudonocardiales	201174|Actinobacteria	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030312,GO:0040007,GO:0044464,GO:0071944	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
HKD2_k127_2687919_4	522306.CAP2UW1_2920	2.218e-48	189.0	COG0491@1|root,COG0491@2|Bacteria,1R9Z7@1224|Proteobacteria,2W4T9@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HKD2_k127_2687919_5	324602.Caur_3248	1.097e-28	121.0	COG3241@1|root,COG3241@2|Bacteria,2G9Q8@200795|Chloroflexi,375YV@32061|Chloroflexia	32061|Chloroflexia	C	Copper binding proteins, plastocyanin/azurin family	-	GO:0008150,GO:0008152,GO:0055114	-	-	-	-	-	-	-	-	-	-	Copper-bind
HKD2_k127_2687919_6	1206743.BAGM01000209_gene283	3.141e-14	80.0	COG1309@1|root,COG1309@2|Bacteria,2IEU9@201174|Actinobacteria,4G13J@85025|Nocardiaceae	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
HKD2_k127_2691128_0	448385.sce9217	6.126e-58	204.0	COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,42MH9@68525|delta/epsilon subdivisions,2WJE0@28221|Deltaproteobacteria,2YTZT@29|Myxococcales	28221|Deltaproteobacteria	U	General secretion pathway protein F	gspF	-	-	ko:K02455,ko:K02653	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15,3.A.15.2	-	-	T2SSF
HKD2_k127_2691128_3	1192034.CAP_6344	2.457e-17	92.0	COG2165@1|root,COG2165@2|Bacteria	2|Bacteria	NU	general secretion pathway protein	-	-	-	ko:K02456	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl,T2SSG
HKD2_k127_2691128_1	1254432.SCE1572_51975	1.239e-47	180.0	COG4970@1|root,COG4970@2|Bacteria,1QZTS@1224|Proteobacteria,43CNR@68525|delta/epsilon subdivisions,2X7W1@28221|Deltaproteobacteria,2Z3IR@29|Myxococcales	28221|Deltaproteobacteria	NU	Prokaryotic N-terminal methylation motif	-	-	-	ko:K02457	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl
HKD2_k127_2699464_3	443144.GM21_3940	7.359e-28	124.0	COG0671@1|root,COG0671@2|Bacteria,1RIRR@1224|Proteobacteria,42X79@68525|delta/epsilon subdivisions,2WXA0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	Acid phosphatase homologues	-	-	-	-	-	-	-	-	-	-	-	-	PAP2
HKD2_k127_2699464_1	98439.AJLL01000034_gene2878	3.379e-58	207.0	28YPV@1|root,2ZKHE@2|Bacteria,1G75C@1117|Cyanobacteria,1JK29@1189|Stigonemataceae	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2699464_2	211114.JOEF01000009_gene1674	3.791e-29	123.0	2BPUP@1|root,32IN9@2|Bacteria,2H785@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2699464_0	1242864.D187_010262	5.616e-59	209.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD2_k127_2702046_0	243231.GSU2782	2.611e-248	782.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJ8D@28221|Deltaproteobacteria,43S5E@69541|Desulfuromonadales	28221|Deltaproteobacteria	V	AcrB/AcrD/AcrF family	-	-	-	ko:K03296,ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
HKD2_k127_2705172_1	566466.NOR53_518	6.105e-79	284.0	28ID6@1|root,2Z8FE@2|Bacteria,1MX0W@1224|Proteobacteria,1S2X2@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2705172_2	1144275.COCOR_07453	3.692e-73	254.0	COG0500@1|root,COG2226@2|Bacteria,1NNAN@1224|Proteobacteria	1224|Proteobacteria	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
HKD2_k127_2705172_0	215803.DB30_5174	8.761e-101	351.0	COG3291@1|root,COG5492@1|root,COG3291@2|Bacteria,COG5492@2|Bacteria,1PEIB@1224|Proteobacteria,439WA@68525|delta/epsilon subdivisions,2X5AJ@28221|Deltaproteobacteria,2YWZV@29|Myxococcales	28221|Deltaproteobacteria	N	Chitobiase/beta-hexosaminidase C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	CHB_HEX_C_1
HKD2_k127_2705172_4	383372.Rcas_1608	1.731e-25	109.0	COG1743@1|root,COG2852@1|root,COG1743@2|Bacteria,COG2852@2|Bacteria,2G5MZ@200795|Chloroflexi,377J3@32061|Chloroflexia	32061|Chloroflexia	L	Protein of unknown function (DUF1156)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1156
HKD2_k127_2705172_3	1278073.MYSTI_03333	2.054e-53	192.0	COG0204@1|root,COG0204@2|Bacteria,1PZS9@1224|Proteobacteria,434JR@68525|delta/epsilon subdivisions,2WYX1@28221|Deltaproteobacteria,2Z0U7@29|Myxococcales	28221|Deltaproteobacteria	I	Phosphate acyltransferases	-	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
HKD2_k127_2717838_0	448385.sce6673	1.245e-80	282.0	COG1633@1|root,COG1633@2|Bacteria,1PZ9S@1224|Proteobacteria,435U6@68525|delta/epsilon subdivisions,2X09F@28221|Deltaproteobacteria,2Z1G1@29|Myxococcales	28221|Deltaproteobacteria	S	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2719028_1	247490.KSU1_B0458	1.619e-70	243.0	COG0364@1|root,COG0364@2|Bacteria,2IXCV@203682|Planctomycetes	203682|Planctomycetes	G	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone	zwf	-	1.1.1.363,1.1.1.49	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	M00004,M00006,M00008	R00835,R02736,R10907	RC00001,RC00066	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	G6PD_C,G6PD_N
HKD2_k127_2719028_0	1267535.KB906767_gene3854	5.537e-150	499.0	COG1023@1|root,COG1023@2|Bacteria,3Y2ZP@57723|Acidobacteria,2JJT6@204432|Acidobacteriia	204432|Acidobacteriia	G	6-phosphogluconate dehydrogenase, C-terminal domain	-	-	1.1.1.343,1.1.1.44	ko:K00033	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200	M00004,M00006	R01528,R10221	RC00001,RC00539	ko00000,ko00001,ko00002,ko01000	-	-	-	6PGD,NAD_binding_2
HKD2_k127_2719028_2	1254432.SCE1572_38670	8.207e-56	211.0	COG0625@1|root,COG0625@2|Bacteria,1MYW2@1224|Proteobacteria,430KE@68525|delta/epsilon subdivisions,2WVTX@28221|Deltaproteobacteria,2Z15A@29|Myxococcales	28221|Deltaproteobacteria	O	Belongs to the GST superfamily	-	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C,GST_N
HKD2_k127_2719963_2	448385.sce7264	4.305e-112	364.0	COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,42M5E@68525|delta/epsilon subdivisions,2WIV6@28221|Deltaproteobacteria,2YTXT@29|Myxococcales	28221|Deltaproteobacteria	J	Ribonuclease E/G family	cafA	-	-	ko:K08301	-	-	-	-	ko00000,ko01000,ko03009,ko03019	-	-	-	RNase_E_G,S1
HKD2_k127_2719963_5	1254432.SCE1572_42340	5.386e-37	145.0	COG3215@1|root,COG3215@2|Bacteria,1QZU1@1224|Proteobacteria,43CP3@68525|delta/epsilon subdivisions,2X7WD@28221|Deltaproteobacteria,2Z2BM@29|Myxococcales	28221|Deltaproteobacteria	NU	PilZ domain	-	-	-	-	-	-	-	-	-	-	-	-	PilZ
HKD2_k127_2719963_7	1206737.BAGF01000049_gene3042	1.34e-11	77.0	2EDTC@1|root,337NP@2|Bacteria,2IG6I@201174|Actinobacteria,4FUC9@85025|Nocardiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2719963_0	1382306.JNIM01000001_gene221	2.966e-149	481.0	COG0627@1|root,COG0627@2|Bacteria	2|Bacteria	J	Serine hydrolase involved in the detoxification of formaldehyde	-	-	-	-	-	-	-	-	-	-	-	-	Esterase
HKD2_k127_2719963_3	1121423.JONT01000008_gene746	3.293e-77	263.0	COG0605@1|root,COG0605@2|Bacteria,1TPXT@1239|Firmicutes,24HDS@186801|Clostridia,260SB@186807|Peptococcaceae	186801|Clostridia	P	Destroys radicals which are normally produced within the cells and which are toxic to biological systems	sodA	-	1.15.1.1	ko:K04564	ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016	-	-	-	ko00000,ko00001,ko01000	-	-	-	Sod_Fe_C,Sod_Fe_N
HKD2_k127_2719963_4	1192034.CAP_6096	3.533e-40	160.0	COG1309@1|root,COG1309@2|Bacteria,1RG78@1224|Proteobacteria,4354N@68525|delta/epsilon subdivisions,2WZFQ@28221|Deltaproteobacteria,2Z21D@29|Myxococcales	28221|Deltaproteobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
HKD2_k127_2719963_1	391625.PPSIR1_18972	1.206e-120	403.0	COG2124@1|root,COG2124@2|Bacteria,1MV75@1224|Proteobacteria,42NH2@68525|delta/epsilon subdivisions,2X2MT@28221|Deltaproteobacteria,2YTVU@29|Myxococcales	28221|Deltaproteobacteria	C	cytochrome P450	-	-	-	-	-	-	-	-	-	-	-	-	p450
HKD2_k127_2719963_6	1297742.A176_06464	5.247e-32	139.0	COG1488@1|root,COG1488@2|Bacteria,1R5W0@1224|Proteobacteria,42NQQ@68525|delta/epsilon subdivisions,2WJ4V@28221|Deltaproteobacteria,2YU8U@29|Myxococcales	28221|Deltaproteobacteria	H	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP	-	-	6.3.4.21	ko:K00763	ko00760,ko01100,map00760,map01100	-	R01724	RC00033	ko00000,ko00001,ko01000	-	-	-	NAPRTase,QRPTase_C
HKD2_k127_2722725_3	1392490.JHZX01000001_gene210	5.078e-43	174.0	COG4775@1|root,COG4775@2|Bacteria,4NMIQ@976|Bacteroidetes,1I1IX@117743|Flavobacteriia	976|Bacteroidetes	M	Surface antigen	-	-	-	-	-	-	-	-	-	-	-	-	Bac_surface_Ag
HKD2_k127_2722725_2	1123229.AUBC01000001_gene1533	6.052e-58	221.0	COG4106@1|root,COG4106@2|Bacteria,1QWJU@1224|Proteobacteria,2TWZZ@28211|Alphaproteobacteria,3K6QN@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
HKD2_k127_2722725_0	1192034.CAP_0217	6.186e-92	329.0	298PG@1|root,2ZVTY@2|Bacteria,1RIKV@1224|Proteobacteria,433IU@68525|delta/epsilon subdivisions,2WXIH@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2722725_5	448385.sce4208	1.753e-15	87.0	2EDTI@1|root,337NU@2|Bacteria,1Q2MU@1224|Proteobacteria,4388F@68525|delta/epsilon subdivisions,2X3I4@28221|Deltaproteobacteria,2YW70@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2722725_1	404589.Anae109_3912	6.264e-71	259.0	COG0642@1|root,COG3829@1|root,COG2205@2|Bacteria,COG3829@2|Bacteria,1QV0D@1224|Proteobacteria	1224|Proteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HATPase_c,HisKA,MEDS,PAS_4,RsbRD_N
HKD2_k127_2722725_4	572477.Alvin_2814	1.957e-37	145.0	28HUW@1|root,2Z81F@2|Bacteria,1Q3QA@1224|Proteobacteria,1RPFU@1236|Gammaproteobacteria,1WWUK@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2722981_3	1206730.BAGA01000065_gene1406	4.729e-39	145.0	COG2314@1|root,COG2314@2|Bacteria,2IQB3@201174|Actinobacteria,4G2DT@85025|Nocardiaceae	201174|Actinobacteria	S	TM2 domain	-	-	-	-	-	-	-	-	-	-	-	-	TM2
HKD2_k127_2722981_1	448385.sce1364	1.401e-129	425.0	COG0389@1|root,COG0389@2|Bacteria,1MUUH@1224|Proteobacteria,42NGG@68525|delta/epsilon subdivisions,2WIVT@28221|Deltaproteobacteria,2YU4K@29|Myxococcales	28221|Deltaproteobacteria	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	dinB	-	2.7.7.7	ko:K02346	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C,IMS_HHH
HKD2_k127_2722981_0	448385.sce8288	1.202e-193	614.0	COG0015@1|root,COG0015@2|Bacteria,1MV4B@1224|Proteobacteria,42MYS@68525|delta/epsilon subdivisions,2WJ2E@28221|Deltaproteobacteria,2YUJM@29|Myxococcales	28221|Deltaproteobacteria	F	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily	purB	-	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	-	ADSL_C,Lyase_1
HKD2_k127_2722981_2	1254432.SCE1572_45460	3.605e-61	227.0	COG2382@1|root,COG2382@2|Bacteria	2|Bacteria	P	enterobactin catabolic process	-	-	-	ko:K07214	-	-	-	-	ko00000	-	-	-	Esterase
HKD2_k127_2722981_4	1297742.A176_02322	1.443e-05	53.0	2ENNG@1|root,33G9U@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2751132_3	448385.sce0417	2.051e-92	313.0	COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,42M4Z@68525|delta/epsilon subdivisions,2WJ0D@28221|Deltaproteobacteria,2YUHW@29|Myxococcales	28221|Deltaproteobacteria	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	-	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,Peptidase_M41
HKD2_k127_2751132_5	194439.CT0949	7.343e-35	141.0	COG1765@1|root,COG1765@2|Bacteria,1FE41@1090|Chlorobi	1090|Chlorobi	O	PFAM OsmC family protein	-	-	-	ko:K09136	-	-	-	-	ko00000,ko03009	-	-	-	OsmC
HKD2_k127_2751132_7	232721.Ajs_1500	1.043e-23	109.0	2C6BU@1|root,32S87@2|Bacteria,1NIFE@1224|Proteobacteria,2VRGB@28216|Betaproteobacteria,4AH6Q@80864|Comamonadaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2751132_0	1254432.SCE1572_17605	8.932e-206	657.0	COG0514@1|root,COG0514@2|Bacteria,1MVGG@1224|Proteobacteria,42MV3@68525|delta/epsilon subdivisions,2WJZB@28221|Deltaproteobacteria,2YX5W@29|Myxococcales	28221|Deltaproteobacteria	L	DNA helicase	-	-	3.6.4.12	ko:K03654	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,HRDC,Helicase_C,RQC,RecQ_Zn_bind
HKD2_k127_2751132_6	1242864.D187_004198	8.833e-34	150.0	COG0726@1|root,COG0726@2|Bacteria,1R881@1224|Proteobacteria	1224|Proteobacteria	G	polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
HKD2_k127_2751132_4	1192034.CAP_2274	7.604e-65	230.0	COG0225@1|root,COG0225@2|Bacteria,1MVUS@1224|Proteobacteria,42NB7@68525|delta/epsilon subdivisions,2WNTJ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	msrA	-	1.8.4.11,1.8.4.12	ko:K07304,ko:K12267	-	-	-	-	ko00000,ko01000	-	-	-	PMSR,SelR
HKD2_k127_2751132_1	448385.sce4007	1.2e-152	494.0	COG1716@1|root,COG2204@1|root,COG1716@2|Bacteria,COG2204@2|Bacteria	2|Bacteria	T	phosphorelay signal transduction system	-	-	4.6.1.1	ko:K01768,ko:K10941,ko:K11894	ko00230,ko02020,ko02025,ko04113,ko04213,ko05111,map00230,map02020,map02025,map04113,map04213,map05111	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000,ko02044,ko03000	3.A.23.1	-	-	FHA,GAF_2,HTH_8,Sigma54_activat,Yop-YscD_cpl
HKD2_k127_2751132_2	1254432.SCE1572_42585	1.207e-105	363.0	COG0192@1|root,COG0192@2|Bacteria,1MUFQ@1224|Proteobacteria,42MFM@68525|delta/epsilon subdivisions,2WIQ3@28221|Deltaproteobacteria,2YUBT@29|Myxococcales	28221|Deltaproteobacteria	H	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme	metK	GO:0003674,GO:0003824,GO:0004478,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016740,GO:0016765,GO:0044424,GO:0044444,GO:0044464	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
HKD2_k127_2758372_1	1144275.COCOR_05710	3.076e-98	334.0	COG3919@1|root,COG3919@2|Bacteria	2|Bacteria	E	ATP-grasp	yxbA	-	6.3.1.12	ko:K17810	-	-	-	-	ko00000,ko01000	-	-	-	CPSase_L_D2
HKD2_k127_2758372_0	483219.LILAB_19495	1.29e-117	395.0	COG0019@1|root,COG0019@2|Bacteria,1MUA6@1224|Proteobacteria,42KZH@68525|delta/epsilon subdivisions,2WIRM@28221|Deltaproteobacteria,2YUK3@29|Myxococcales	28221|Deltaproteobacteria	E	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine	-	-	4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
HKD2_k127_2758372_2	1278073.MYSTI_02776	3.49e-81	289.0	COG0745@1|root,COG0784@1|root,COG4191@1|root,COG0745@2|Bacteria,COG0784@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42PZ5@68525|delta/epsilon subdivisions,2WM5Q@28221|Deltaproteobacteria,2Z2WF@29|Myxococcales	28221|Deltaproteobacteria	T	PAS fold	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_4,PAS_8,PAS_9,Response_reg
HKD2_k127_2758372_5	1192034.CAP_2400	1.259e-17	98.0	COG3221@1|root,COG3221@2|Bacteria,1MXD8@1224|Proteobacteria,42VZ4@68525|delta/epsilon subdivisions,2WRDI@28221|Deltaproteobacteria,2YW4T@29|Myxococcales	28221|Deltaproteobacteria	P	ABC transporter, phosphonate, periplasmic substrate-binding protein	phnD	-	-	ko:K02044	ko02010,map02010	M00223	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.9	-	-	Phosphonate-bd
HKD2_k127_2759835_0	1254432.SCE1572_41940	8.065e-79	293.0	COG0419@1|root,COG4717@1|root,COG0419@2|Bacteria,COG4717@2|Bacteria,1MVAW@1224|Proteobacteria,42MYC@68525|delta/epsilon subdivisions,2WJXA@28221|Deltaproteobacteria,2Z2A3@29|Myxococcales	28221|Deltaproteobacteria	L	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_27
HKD2_k127_2762753_1	1254432.SCE1572_42080	3.606e-90	303.0	COG0745@1|root,COG2202@1|root,COG2203@1|root,COG5002@1|root,COG0745@2|Bacteria,COG2202@2|Bacteria,COG2203@2|Bacteria,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,43CW5@68525|delta/epsilon subdivisions,2X845@28221|Deltaproteobacteria,2Z3KI@29|Myxococcales	28221|Deltaproteobacteria	KT	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HisKA,PAS,Response_reg
HKD2_k127_2762753_2	1254432.SCE1572_42085	4.225e-68	247.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42S9W@68525|delta/epsilon subdivisions,2WNX4@28221|Deltaproteobacteria,2YUXR@29|Myxococcales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_4,PAS_8
HKD2_k127_2762753_0	448385.sce8008	4.483e-138	475.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,434IZ@68525|delta/epsilon subdivisions,2X8WW@28221|Deltaproteobacteria,2Z0SD@29|Myxococcales	28221|Deltaproteobacteria	KLT	Protein kinase domain	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase,TPR_19
HKD2_k127_2762753_6	335283.Neut_2531	4.343e-16	90.0	COG3108@1|root,COG3108@2|Bacteria,1MWW2@1224|Proteobacteria,2VRCS@28216|Betaproteobacteria,3737H@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Bacterial protein of unknown function (DUF882)	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M15_2
HKD2_k127_2762753_7	290397.Adeh_2522	7.06e-12	73.0	COG0775@1|root,COG0775@2|Bacteria	2|Bacteria	F	adenosylhomocysteine nucleosidase activity	mqnB	GO:0003674,GO:0003824,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009233,GO:0009234,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663	2.4.2.1,3.2.2.26,3.2.2.9	ko:K01243,ko:K03784,ko:K11783	ko00130,ko00230,ko00240,ko00270,ko00760,ko01100,ko01110,ko01230,map00130,map00230,map00240,map00270,map00760,map01100,map01110,map01230	M00034,M00609	R00194,R01401,R01561,R01863,R01969,R02147,R02294,R02295,R02297,R02484,R02557,R02748,R08368,R08587,R10244	RC00033,RC00063,RC00122,RC00318	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
HKD2_k127_2762753_3	448385.sce8005	1.823e-48	173.0	COG1145@1|root,COG1145@2|Bacteria,1MZ6H@1224|Proteobacteria,42U8W@68525|delta/epsilon subdivisions,2X3DV@28221|Deltaproteobacteria,2YVMF@29|Myxococcales	28221|Deltaproteobacteria	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_7
HKD2_k127_2763344_0	448385.sce2633	1.245e-262	818.0	COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,42N8X@68525|delta/epsilon subdivisions,2WIVR@28221|Deltaproteobacteria,2YUID@29|Myxococcales	28221|Deltaproteobacteria	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
HKD2_k127_2765663_3	83406.HDN1F_09800	1.998e-48	185.0	COG1309@1|root,COG1309@2|Bacteria	2|Bacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_6,TetR_N
HKD2_k127_2765663_7	411684.HPDFL43_03511	5.959e-38	148.0	COG3759@1|root,COG3759@2|Bacteria,1MZ4F@1224|Proteobacteria,2UBW9@28211|Alphaproteobacteria,43PE0@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1304)	MA20_23345	-	-	ko:K08987	-	-	-	-	ko00000	-	-	-	DUF1304
HKD2_k127_2765663_9	391625.PPSIR1_11260	4.882e-29	130.0	COG3831@1|root,COG4886@1|root,COG3831@2|Bacteria,COG4886@2|Bacteria,1RIXB@1224|Proteobacteria,431YE@68525|delta/epsilon subdivisions,2WWAE@28221|Deltaproteobacteria,2YUSW@29|Myxococcales	28221|Deltaproteobacteria	S	WGR domain protein	-	-	-	-	-	-	-	-	-	-	-	-	LRR_6,WGR
HKD2_k127_2765663_0	1192034.CAP_4200	1.233e-199	649.0	COG3537@1|root,COG3537@2|Bacteria,1MXCY@1224|Proteobacteria,43BAT@68525|delta/epsilon subdivisions,2X6PZ@28221|Deltaproteobacteria,2YX4I@29|Myxococcales	28221|Deltaproteobacteria	G	Glycosyl hydrolase family 92	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_92
HKD2_k127_2765663_5	1192034.CAP_3828	1.515e-39	156.0	COG1670@1|root,COG1670@2|Bacteria	2|Bacteria	J	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins	mshD	-	2.3.1.189	ko:K15520	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_1,Acetyltransf_3
HKD2_k127_2765663_1	1254432.SCE1572_32370	2.871e-162	527.0	COG0596@1|root,COG0596@2|Bacteria,1MWW8@1224|Proteobacteria,42P6R@68525|delta/epsilon subdivisions,2WKXS@28221|Deltaproteobacteria,2YUES@29|Myxococcales	28221|Deltaproteobacteria	E	Belongs to the peptidase S33 family	pip	-	3.4.11.5	ko:K01259	ko00330,map00330	-	R00135	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Abhydrolase_1
HKD2_k127_2765663_8	1192034.CAP_6421	1.598e-33	145.0	2ENGF@1|root,33G3Y@2|Bacteria,1P8WT@1224|Proteobacteria,43261@68525|delta/epsilon subdivisions,2WXJG@28221|Deltaproteobacteria,2YVTG@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2765663_10	743720.Psefu_2630	1.297e-20	102.0	COG1633@1|root,COG1633@2|Bacteria,1PZ2E@1224|Proteobacteria,1TARY@1236|Gammaproteobacteria,1YY5M@136845|Pseudomonas putida group	1236|Gammaproteobacteria	S	Domain of unknown function (DUF2383)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2383
HKD2_k127_2765663_2	1254432.SCE1572_41450	3.229e-79	275.0	28MSG@1|root,2ZB0U@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF2515)	yppC	-	-	-	-	-	-	-	-	-	-	-	DUF2515
HKD2_k127_2775245_0	448385.sce3915	3.133e-85	287.0	COG0177@1|root,COG0177@2|Bacteria,1MUYQ@1224|Proteobacteria,42N6I@68525|delta/epsilon subdivisions,2WNYM@28221|Deltaproteobacteria,2Z06C@29|Myxococcales	28221|Deltaproteobacteria	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD
HKD2_k127_2775245_2	502025.Hoch_5573	1.449e-16	93.0	2CKRK@1|root,347NN@2|Bacteria,1P3S8@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2775245_3	551789.ATVJ01000001_gene1518	3.042e-07	58.0	COG2207@1|root,COG2207@2|Bacteria,1MX23@1224|Proteobacteria,2TT6H@28211|Alphaproteobacteria,44051@69657|Hyphomonadaceae	28211|Alphaproteobacteria	K	Arabinose-binding domain of AraC transcription regulator, N-term	-	-	-	-	-	-	-	-	-	-	-	-	Arabinose_bd,HTH_18
HKD2_k127_2775245_1	682795.AciX8_0739	8.042e-65	240.0	COG0402@1|root,COG0402@2|Bacteria	2|Bacteria	F	S-adenosylhomocysteine deaminase activity	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
HKD2_k127_2777721_0	391625.PPSIR1_09710	1.039e-57	222.0	2DBCT@1|root,2Z8FK@2|Bacteria,1NMHH@1224|Proteobacteria	1224|Proteobacteria	S	protein contain chitin-binding domain type 3	-	-	-	-	-	-	-	-	-	-	-	-	N-glycanase_C,N-glycanase_N
HKD2_k127_2779664_0	1192034.CAP_3569	4.521e-163	520.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,42MK5@68525|delta/epsilon subdivisions,2WJ3Z@28221|Deltaproteobacteria,2YU5D@29|Myxococcales	28221|Deltaproteobacteria	C	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HKD2_k127_2779664_4	1121918.ARWE01000001_gene3170	3.579e-25	121.0	COG1520@1|root,COG4886@1|root,COG1520@2|Bacteria,COG4886@2|Bacteria,1PIDG@1224|Proteobacteria,42UM6@68525|delta/epsilon subdivisions,2WPZY@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PQQ-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_3
HKD2_k127_2779664_1	448385.sce3766	2.75e-92	322.0	COG0515@1|root,COG0515@2|Bacteria,1PFJ6@1224|Proteobacteria,4340Z@68525|delta/epsilon subdivisions,2X4J2@28221|Deltaproteobacteria,2YZ45@29|Myxococcales	28221|Deltaproteobacteria	KLT	Protein kinase domain	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
HKD2_k127_2779664_3	1123508.JH636450_gene7219	7.351e-44	173.0	COG1404@1|root,COG2911@1|root,COG2931@1|root,COG3210@1|root,COG3391@1|root,COG4935@1|root,COG1404@2|Bacteria,COG2911@2|Bacteria,COG2931@2|Bacteria,COG3210@2|Bacteria,COG3391@2|Bacteria,COG4935@2|Bacteria,2IZWN@203682|Planctomycetes	203682|Planctomycetes	Q	HemY domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2779664_2	1230343.CANP01000035_gene2592	6.029e-47	182.0	COG2706@1|root,COG2706@2|Bacteria,1RB38@1224|Proteobacteria,1SNAF@1236|Gammaproteobacteria,1JE2M@118969|Legionellales	118969|Legionellales	G	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2786925_2	1121481.AUAS01000002_gene3310	2.688e-05	55.0	COG0810@1|root,COG0810@2|Bacteria	2|Bacteria	M	energy transducer activity	-	-	-	-	-	-	-	-	-	-	-	-	TonB_C
HKD2_k127_2786925_0	448385.sce7647	1.711e-84	293.0	COG2340@1|root,COG2340@2|Bacteria,1REVB@1224|Proteobacteria,4386P@68525|delta/epsilon subdivisions,2X3GI@28221|Deltaproteobacteria,2YW01@29|Myxococcales	28221|Deltaproteobacteria	S	Cysteine-rich secretory protein family	-	-	-	-	-	-	-	-	-	-	-	-	CAP
HKD2_k127_2786925_1	1192034.CAP_1747	5.737e-60	229.0	COG3170@1|root,COG3170@2|Bacteria,1QX3V@1224|Proteobacteria,43BWB@68525|delta/epsilon subdivisions,2X773@28221|Deltaproteobacteria,2YVT2@29|Myxococcales	28221|Deltaproteobacteria	NU	zinc-ribbon domain	-	-	-	-	-	-	-	-	-	-	-	-	zinc_ribbon_4
HKD2_k127_2793542_3	1192034.CAP_8800	1.449e-10	66.0	COG0236@1|root,COG0236@2|Bacteria	2|Bacteria	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	-	-	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
HKD2_k127_2793542_2	203124.Tery_1772	1.139e-17	98.0	COG3391@1|root,COG3391@2|Bacteria,1G0EB@1117|Cyanobacteria,1H803@1150|Oscillatoriales	1117|Cyanobacteria	G	PFAM Na-Ca exchanger integrin-beta4 peptidase-like FG-GAP	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Calx-beta,DUF4347,He_PIG,HemolysinCabind,PPC,TIG,VCBS
HKD2_k127_2793542_0	309799.DICTH_0538	2.711e-81	284.0	COG0156@1|root,COG0156@2|Bacteria	2|Bacteria	E	8-amino-7-oxononanoate synthase activity	bioF	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	2.3.1.29,2.3.1.47	ko:K00639,ko:K00652	ko00260,ko00780,ko01100,map00260,map00780,map01100	M00123,M00573,M00577	R00371,R03210,R10124	RC00004,RC00039,RC00394,RC02725	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
HKD2_k127_279990_2	448385.sce4321	6.088e-132	431.0	COG0119@1|root,COG0119@2|Bacteria,1MUMX@1224|Proteobacteria,42Q6T@68525|delta/epsilon subdivisions,2WIN1@28221|Deltaproteobacteria,2Z2XK@29|Myxococcales	28221|Deltaproteobacteria	E	HMGL-like	mvaB	-	4.1.3.4	ko:K01640	ko00072,ko00280,ko00281,ko00650,ko01100,ko04146,map00072,map00280,map00281,map00650,map01100,map04146	M00036,M00088	R01360,R08090	RC00502,RC00503,RC01118,RC01946	ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like
HKD2_k127_279990_4	1005048.CFU_0470	4.493e-95	325.0	COG0654@1|root,COG0654@2|Bacteria,1MUZP@1224|Proteobacteria,2VTAP@28216|Betaproteobacteria,475PE@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	FAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3
HKD2_k127_279990_1	448385.sce4320	2.515e-198	634.0	COG0034@1|root,COG0034@2|Bacteria,1MU0V@1224|Proteobacteria,42MDB@68525|delta/epsilon subdivisions,2WITV@28221|Deltaproteobacteria,2YTTF@29|Myxococcales	28221|Deltaproteobacteria	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	-	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_6,GATase_7,Pribosyltran
HKD2_k127_279990_5	1254432.SCE1572_43070	7.973e-45	176.0	COG5640@1|root,COG5640@2|Bacteria	2|Bacteria	O	serine-type endopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Trypsin
HKD2_k127_279990_8	1382304.JNIL01000001_gene2639	2.829e-06	53.0	COG0454@1|root,COG0456@2|Bacteria,1VJPU@1239|Firmicutes,4HXYC@91061|Bacilli,27AFB@186823|Alicyclobacillaceae	91061|Bacilli	K	FR47-like protein	-	-	-	-	-	-	-	-	-	-	-	-	FR47
HKD2_k127_279990_6	1267533.KB906734_gene3829	1.615e-32	135.0	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HKD2_k127_279990_0	1192034.CAP_7320	1.087e-263	822.0	COG0515@1|root,COG0515@2|Bacteria	1192034.CAP_7320|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_279990_9	1379858.N508_01253	0.0003393	47.0	2EM0R@1|root,33EQ9@2|Bacteria,2GG28@200930|Deferribacteres	200930|Deferribacteres	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_279990_3	1254432.SCE1572_49400	5.223e-130	431.0	COG1233@1|root,COG1233@2|Bacteria,1Q2HN@1224|Proteobacteria,4384H@68525|delta/epsilon subdivisions,2X3EF@28221|Deltaproteobacteria,2YVQ0@29|Myxococcales	28221|Deltaproteobacteria	Q	COG1233 Phytoene dehydrogenase and related	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_8
HKD2_k127_2802547_0	1192034.CAP_6406	4.375e-266	827.0	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,42M2A@68525|delta/epsilon subdivisions,2WIJY@28221|Deltaproteobacteria,2YUEB@29|Myxococcales	28221|Deltaproteobacteria	S	ATPase components of ABC transporters with duplicated ATPase domains	-	-	-	ko:K06158	-	-	-	-	ko00000,ko03012	-	-	-	ABC_tran,ABC_tran_Xtn
HKD2_k127_2840174_2	1192034.CAP_4064	4.757e-104	357.0	COG3291@1|root,COG3291@2|Bacteria	2|Bacteria	S	metallopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	CBM60,CHU_C,Glyco_hydro_8,IgGFc_binding,PA14,PKD,PQQ,PQQ_2,fn3
HKD2_k127_2840174_8	1173025.GEI7407_3406	5.286e-55	203.0	COG0300@1|root,COG0300@2|Bacteria,1G2JD@1117|Cyanobacteria,1H8N9@1150|Oscillatoriales	1117|Cyanobacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	ko:K07124	-	-	-	-	ko00000	-	-	-	adh_short
HKD2_k127_2840174_0	33876.JNXY01000003_gene118	1.104e-240	797.0	COG3831@1|root,COG3831@2|Bacteria,2HIEQ@201174|Actinobacteria,4D9WJ@85008|Micromonosporales	201174|Actinobacteria	S	Domain of unknown function (DUF4132)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4132,WGR
HKD2_k127_2840174_12	1207075.PputUW4_02590	8.395e-08	67.0	COG4447@1|root,COG4447@2|Bacteria,1R84R@1224|Proteobacteria,1SZVU@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	protein related to plant photosystem II stability assembly factor	-	-	-	-	-	-	-	-	-	-	-	-	PSII_BNR
HKD2_k127_2840174_6	1254432.SCE1572_26150	9.178e-77	279.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,42MVV@68525|delta/epsilon subdivisions,2X4JB@28221|Deltaproteobacteria,2YZ4I@29|Myxococcales	28221|Deltaproteobacteria	KLT	Family membership	-	-	2.7.11.1	ko:K08884	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HKD2_k127_2840174_9	290400.Jann_3481	3.761e-38	150.0	COG3224@1|root,COG3224@2|Bacteria,1QUU7@1224|Proteobacteria	1224|Proteobacteria	S	Antibiotic biosynthesis monooxygenase	-	-	-	ko:K09932	-	-	-	-	ko00000	-	-	-	ABM
HKD2_k127_2840174_10	550540.Fbal_1133	6.683e-27	117.0	COG1472@1|root,COG1472@2|Bacteria,1QUPT@1224|Proteobacteria,1T20E@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Protein of unknown function (DUF3365)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3365
HKD2_k127_2840174_5	448385.sce6656	7.385e-83	295.0	COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria	2|Bacteria	K	PFAM sigma-54 factor interaction domain-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	FHA,HTH_8,Sigma54_activat,Yop-YscD_cpl
HKD2_k127_2840174_3	215803.DB30_1845	1.378e-102	347.0	COG1502@1|root,COG1502@2|Bacteria,1R9I4@1224|Proteobacteria,4340H@68525|delta/epsilon subdivisions,2X4F2@28221|Deltaproteobacteria,2YYWF@29|Myxococcales	28221|Deltaproteobacteria	I	Phospholipase D. Active site motifs.	-	-	-	-	-	-	-	-	-	-	-	-	PLDc_2
HKD2_k127_2840174_11	472759.Nhal_0817	3.148e-22	113.0	2DC00@1|root,2ZC4V@2|Bacteria,1RBPR@1224|Proteobacteria,1S2KT@1236|Gammaproteobacteria,1X0Y7@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2840174_7	1254432.SCE1572_07050	1.156e-59	234.0	COG3119@1|root,COG3119@2|Bacteria,1QZST@1224|Proteobacteria,43CMS@68525|delta/epsilon subdivisions,2X7UX@28221|Deltaproteobacteria,2Z29A@29|Myxococcales	28221|Deltaproteobacteria	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
HKD2_k127_2840174_1	391625.PPSIR1_28641	2.566e-169	538.0	COG0714@1|root,COG0714@2|Bacteria,1QAW5@1224|Proteobacteria,42PY2@68525|delta/epsilon subdivisions,2WKGF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM ATPase associated with various cellular activities, AAA_5	-	-	-	ko:K04748	-	-	R00294	RC02794	ko00000	3.D.4.10	-	-	AAA_5,CbbQ_C
HKD2_k127_2840174_4	1183438.GKIL_3712	9.338e-88	295.0	COG4798@1|root,COG4798@2|Bacteria,1GCU2@1117|Cyanobacteria	1117|Cyanobacteria	S	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2845508_0	1192034.CAP_2075	3.833e-206	658.0	COG0646@1|root,COG0685@1|root,COG0646@2|Bacteria,COG0685@2|Bacteria,1NPFY@1224|Proteobacteria,42PRW@68525|delta/epsilon subdivisions,2WIMG@28221|Deltaproteobacteria,2YYG9@29|Myxococcales	28221|Deltaproteobacteria	H	Methylenetetrahydrofolate reductase	metF-2	-	1.5.1.20,2.1.1.10	ko:K00297,ko:K00547	ko00270,ko00670,ko00720,ko01100,ko01110,ko01120,ko01200,ko01523,map00270,map00670,map00720,map01100,map01110,map01120,map01200,map01523	M00377	R00650,R01224,R07168	RC00003,RC00035,RC00081	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_0504	MTHFR,S-methyl_trans
HKD2_k127_2845508_7	1254432.SCE1572_32030	4.305e-22	108.0	COG0457@1|root,COG0457@2|Bacteria,1Q9KT@1224|Proteobacteria,43DTC@68525|delta/epsilon subdivisions,2WYTS@28221|Deltaproteobacteria,2Z0KP@29|Myxococcales	28221|Deltaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2845508_3	1192034.CAP_8267	8.428e-87	323.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,42MVV@68525|delta/epsilon subdivisions,2X4JB@28221|Deltaproteobacteria,2YZ4I@29|Myxococcales	68525|delta/epsilon subdivisions	KLT	Family membership	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PP2C_2,Pkinase
HKD2_k127_2845508_1	448385.sce9031	3.137e-182	584.0	COG0277@1|root,COG0277@2|Bacteria,1MXTV@1224|Proteobacteria,42RXR@68525|delta/epsilon subdivisions,2WNHV@28221|Deltaproteobacteria,2YXRA@29|Myxococcales	28221|Deltaproteobacteria	C	FAD linked oxidases, C-terminal domain	-	-	2.5.1.26	ko:K00803	ko00565,ko01100,ko04146,map00565,map01100,map04146	-	R04311	RC00020,RC02886	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
HKD2_k127_2845508_6	448385.sce9031	5.371e-24	117.0	COG0277@1|root,COG0277@2|Bacteria,1MXTV@1224|Proteobacteria,42RXR@68525|delta/epsilon subdivisions,2WNHV@28221|Deltaproteobacteria,2YXRA@29|Myxococcales	28221|Deltaproteobacteria	C	FAD linked oxidases, C-terminal domain	-	-	2.5.1.26	ko:K00803	ko00565,ko01100,ko04146,map00565,map01100,map04146	-	R04311	RC00020,RC02886	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
HKD2_k127_2845508_5	1122169.AREN01000015_gene1093	2.11e-36	147.0	COG0537@1|root,COG0537@2|Bacteria,1RDCJ@1224|Proteobacteria,1S3QE@1236|Gammaproteobacteria,1JEIC@118969|Legionellales	118969|Legionellales	FG	Scavenger mRNA decapping enzyme C-term binding	hinT	-	-	ko:K02503	-	-	-	-	ko00000,ko04147	-	-	-	HIT
HKD2_k127_2845508_2	1254432.SCE1572_51305	1.484e-153	504.0	COG0216@1|root,COG0216@2|Bacteria,1MV28@1224|Proteobacteria,42NA3@68525|delta/epsilon subdivisions,2WIQU@28221|Deltaproteobacteria,2YTSK@29|Myxococcales	28221|Deltaproteobacteria	J	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA	prfA	-	-	ko:K02835	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
HKD2_k127_2845508_4	1192034.CAP_1888	1.619e-75	259.0	COG3872@1|root,COG3872@2|Bacteria,1RCB0@1224|Proteobacteria,42R3I@68525|delta/epsilon subdivisions,2WMZR@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Protein of unknown function (DUF1385)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1385
HKD2_k127_2845953_0	1088721.NSU_0076	5.135e-195	634.0	COG3459@1|root,COG3459@2|Bacteria,1MVNX@1224|Proteobacteria,2TSAJ@28211|Alphaproteobacteria,2K0DW@204457|Sphingomonadales	204457|Sphingomonadales	G	Glycosyl hydrolase 36 superfamily, catalytic domain	-	-	-	ko:K13688	-	-	-	-	ko00000,ko01000,ko01003	-	GH94,GT84	-	Glyco_hydro_36,Glyco_transf_36,Glycoamylase
HKD2_k127_2845953_1	397945.Aave_1519	1.61e-05	53.0	COG0589@1|root,COG0589@2|Bacteria,1MZ3K@1224|Proteobacteria,2VQAE@28216|Betaproteobacteria,4AE1K@80864|Comamonadaceae	28216|Betaproteobacteria	T	Universal stress protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD2_k127_2848436_1	448385.sce7214	7.233e-107	364.0	COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,439XM@68525|delta/epsilon subdivisions,2X1UY@28221|Deltaproteobacteria,2Z0MH@29|Myxococcales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
HKD2_k127_2848436_4	1192034.CAP_2852	2.555e-59	236.0	COG0642@1|root,COG2205@2|Bacteria	1192034.CAP_2852|-	T	PhoQ Sensor	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2848436_5	290397.Adeh_3956	2.795e-48	179.0	2A9VF@1|root,30Z3B@2|Bacteria,1PKZS@1224|Proteobacteria,435JG@68525|delta/epsilon subdivisions,2WZXJ@28221|Deltaproteobacteria,2Z0YG@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2848436_3	1123354.AUDR01000013_gene809	4.322e-92	327.0	COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,2VI2V@28216|Betaproteobacteria,1KS54@119069|Hydrogenophilales	119069|Hydrogenophilales	E	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia	trpE	-	4.1.3.27	ko:K01657	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
HKD2_k127_2848436_0	448385.sce6192	3.722e-189	599.0	COG3246@1|root,COG3246@2|Bacteria,1MZTP@1224|Proteobacteria,42QYC@68525|delta/epsilon subdivisions,2WN66@28221|Deltaproteobacteria,2Z2W3@29|Myxococcales	28221|Deltaproteobacteria	S	Pfam:Kce	-	-	2.3.1.247	ko:K18013	ko00310,map00310	-	R10564	RC02728,RC03199	ko00000,ko00001,ko01000	-	-	-	4HBT,BKACE
HKD2_k127_2848436_2	1128421.JAGA01000004_gene2704	1.333e-94	340.0	COG2124@1|root,COG2124@2|Bacteria	2|Bacteria	Q	cytochrome p450	-	-	-	-	-	-	-	-	-	-	-	-	p450
HKD2_k127_2853049_5	1175306.GWL_17350	5.432e-11	64.0	COG2200@1|root,COG2200@2|Bacteria,1MVJY@1224|Proteobacteria,2VK2X@28216|Betaproteobacteria,473WV@75682|Oxalobacteraceae	28216|Betaproteobacteria	T	Putative diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	EAL
HKD2_k127_2853049_4	1192034.CAP_1247	2.15e-56	208.0	2AGKM@1|root,316TT@2|Bacteria,1PY02@1224|Proteobacteria,43DZS@68525|delta/epsilon subdivisions,2WZAI@28221|Deltaproteobacteria,2Z1Q4@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2853049_0	448385.sce4259	3.895e-134	451.0	COG0451@1|root,COG0451@2|Bacteria,1N8PG@1224|Proteobacteria,42TCH@68525|delta/epsilon subdivisions,2WPEI@28221|Deltaproteobacteria,2YU8R@29|Myxococcales	28221|Deltaproteobacteria	GM	GDP-mannose 4,6 dehydratase	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
HKD2_k127_2853049_1	448385.sce4260	8.319e-123	400.0	COG0204@1|root,COG0204@2|Bacteria,1R9IG@1224|Proteobacteria,42T29@68525|delta/epsilon subdivisions,2WPJ8@28221|Deltaproteobacteria,2YUTC@29|Myxococcales	28221|Deltaproteobacteria	I	Acyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acyltransferase
HKD2_k127_2853049_2	1254432.SCE1572_25795	2.732e-91	309.0	COG1619@1|root,COG1619@2|Bacteria,1MWIY@1224|Proteobacteria,42Q52@68525|delta/epsilon subdivisions,2WJ3S@28221|Deltaproteobacteria,2YV3I@29|Myxococcales	28221|Deltaproteobacteria	V	LD-carboxypeptidase	-	-	3.4.17.13	ko:K01297	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_S66
HKD2_k127_2853049_3	710686.Mycsm_01038	2.713e-89	304.0	COG1063@1|root,COG1063@2|Bacteria,2IBQC@201174|Actinobacteria,23300@1762|Mycobacteriaceae	201174|Actinobacteria	E	Alcohol dehydrogenase GroES-like domain	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
HKD2_k127_2861630_0	448385.sce1701	1.276e-81	285.0	2ABSM@1|root,31194@2|Bacteria,1RDYC@1224|Proteobacteria,432T5@68525|delta/epsilon subdivisions,2WY30@28221|Deltaproteobacteria,2YVSJ@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2861630_1	1254432.SCE1572_10690	2.829e-60	214.0	COG0219@1|root,COG0219@2|Bacteria,1RCY4@1224|Proteobacteria,42RJX@68525|delta/epsilon subdivisions,2WQNR@28221|Deltaproteobacteria,2YZSU@29|Myxococcales	28221|Deltaproteobacteria	J	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide	trmL	-	2.1.1.207	ko:K03216	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	SpoU_methylase
HKD2_k127_2861630_4	1123261.AXDW01000014_gene3356	5.058e-06	57.0	COG2885@1|root,COG2885@2|Bacteria,1R4WG@1224|Proteobacteria,1RZN8@1236|Gammaproteobacteria,1X5D2@135614|Xanthomonadales	135614|Xanthomonadales	M	Thrombospondin type 3 repeat	-	-	-	-	-	-	-	-	-	-	-	-	OMP_b-brl,OmpA,TSP_3
HKD2_k127_2867776_1	926550.CLDAP_25590	1.488e-71	250.0	COG1572@1|root,COG1572@2|Bacteria	2|Bacteria	NU	bacterial-type flagellum-dependent cell motility	-	-	-	-	-	-	-	-	-	-	-	-	BatA,CARDB,DUF3367,DUF4091,DUF4159
HKD2_k127_2867776_3	404589.Anae109_0791	5.742e-23	103.0	COG1846@1|root,COG1846@2|Bacteria,1RKAV@1224|Proteobacteria,42VFQ@68525|delta/epsilon subdivisions,2WRWP@28221|Deltaproteobacteria,2YVC3@29|Myxococcales	28221|Deltaproteobacteria	K	helix_turn_helix multiple antibiotic resistance protein	marR	-	-	-	-	-	-	-	-	-	-	-	MarR_2
HKD2_k127_2867776_0	448385.sce4348	2.378e-133	438.0	COG0475@1|root,COG0475@2|Bacteria,1R9PF@1224|Proteobacteria,42RF1@68525|delta/epsilon subdivisions,2WMJJ@28221|Deltaproteobacteria,2Z31T@29|Myxococcales	28221|Deltaproteobacteria	P	Sodium/hydrogen exchanger family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger,PTS_EIIA_2,TrkA_C,TrkA_N
HKD2_k127_2867776_2	1192034.CAP_5647	1.884e-70	254.0	COG1360@1|root,COG1360@2|Bacteria,1MU4S@1224|Proteobacteria,42Q7D@68525|delta/epsilon subdivisions,2WN6T@28221|Deltaproteobacteria,2Z0I0@29|Myxococcales	28221|Deltaproteobacteria	N	OmpA family	-	-	-	ko:K02557	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1	-	-	OmpA
HKD2_k127_2867776_4	518766.Rmar_2288	1.227e-22	104.0	COG5615@1|root,COG5615@2|Bacteria,4P6NC@976|Bacteroidetes,1FK4A@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	S	Domain of unknown function (DUF4149)	-	-	-	-	-	-	-	-	-	-	-	-	CopD
HKD2_k127_2870750_0	1192034.CAP_5911	3.259e-66	229.0	COG3291@1|root,COG3291@2|Bacteria,1QEIS@1224|Proteobacteria,4389M@68525|delta/epsilon subdivisions,2X3J1@28221|Deltaproteobacteria,2YWAB@29|Myxococcales	28221|Deltaproteobacteria	S	IgGFc binding protein	-	-	-	-	-	-	-	-	-	-	-	-	IgGFc_binding
HKD2_k127_2870750_2	383372.Rcas_0264	2.649e-44	179.0	COG5184@1|root,COG5184@2|Bacteria,2G8WU@200795|Chloroflexi,3765G@32061|Chloroflexia	32061|Chloroflexia	DZ	PFAM regulator of chromosome condensation, RCC1	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2870750_3	262724.TT_C0286	1.218e-31	130.0	COG0110@1|root,COG0110@2|Bacteria,1WJTH@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Hexapeptide repeat of succinyl-transferase	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep
HKD2_k127_2870750_1	1192034.CAP_7256	1.563e-57	205.0	COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,42MA7@68525|delta/epsilon subdivisions,2WIPC@28221|Deltaproteobacteria,2YWPY@29|Myxococcales	28221|Deltaproteobacteria	P	Acts as a magnesium transporter	-	-	-	ko:K06213	-	-	-	-	ko00000,ko02000	1.A.26.1	-	-	CBS,MgtE,MgtE_N
HKD2_k127_290057_3	1192034.CAP_5577	4.418e-12	68.0	2DV3U@1|root,33TXD@2|Bacteria,1NUW0@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_290057_1	1192034.CAP_2952	9.511e-125	410.0	COG1902@1|root,COG1902@2|Bacteria,1MVIX@1224|Proteobacteria,4346P@68525|delta/epsilon subdivisions,2X204@28221|Deltaproteobacteria,2YUUQ@29|Myxococcales	28221|Deltaproteobacteria	C	NADH:flavin oxidoreductase / NADH oxidase family	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_FMN
HKD2_k127_290057_0	391625.PPSIR1_25746	4.117e-133	457.0	COG1073@1|root,COG1073@2|Bacteria,1QZSS@1224|Proteobacteria,43CMQ@68525|delta/epsilon subdivisions,2X7UU@28221|Deltaproteobacteria,2YW90@29|Myxococcales	1224|Proteobacteria	S	alpha beta	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_290352_0	926569.ANT_31630	5.656e-149	483.0	COG0677@1|root,COG0677@2|Bacteria,2G5PP@200795|Chloroflexi	200795|Chloroflexi	M	PFAM UDP-glucose GDP-mannose dehydrogenase	-	-	1.1.1.136	ko:K13015	ko00520,map00520	-	R00421	RC00291	ko00000,ko00001,ko01000,ko01005	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
HKD2_k127_290352_2	1192034.CAP_5045	1.198e-60	232.0	COG0392@1|root,COG0392@2|Bacteria,1PPSZ@1224|Proteobacteria,434R6@68525|delta/epsilon subdivisions,2WZ2B@28221|Deltaproteobacteria,2Z16A@29|Myxococcales	28221|Deltaproteobacteria	S	Lysylphosphatidylglycerol synthase TM region	-	-	-	ko:K07027	-	-	-	-	ko00000,ko02000	4.D.2	-	-	LPG_synthase_TM
HKD2_k127_290352_4	448385.sce1059	3.275e-30	124.0	2A7HH@1|root,30WF4@2|Bacteria,1QATQ@1224|Proteobacteria,435AN@68525|delta/epsilon subdivisions,2WZMS@28221|Deltaproteobacteria,2Z2E3@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_290352_1	1192034.CAP_4064	3.443e-138	462.0	COG3291@1|root,COG3291@2|Bacteria	2|Bacteria	S	metallopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	CBM60,CHU_C,Glyco_hydro_8,IgGFc_binding,PA14,PKD,PQQ,PQQ_2,fn3
HKD2_k127_290352_3	448385.sce3783	2.163e-58	207.0	COG1262@1|root,COG1262@2|Bacteria	2|Bacteria	T	PFAM Formylglycine-generating sulfatase enzyme	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase,HdeA
HKD2_k127_290352_5	448385.sce3783	6.265e-06	54.0	COG1262@1|root,COG1262@2|Bacteria	2|Bacteria	T	PFAM Formylglycine-generating sulfatase enzyme	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase,HdeA
HKD2_k127_2906470_4	1254432.SCE1572_37450	6.486e-118	385.0	COG1924@1|root,COG3580@1|root,COG1924@2|Bacteria,COG3580@2|Bacteria,1PKG6@1224|Proteobacteria,42MY4@68525|delta/epsilon subdivisions,2WJFI@28221|Deltaproteobacteria,2YVGM@29|Myxococcales	28221|Deltaproteobacteria	I	CoA-substrate-specific enzyme activase	-	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG,DUF2229,HGD-D
HKD2_k127_2906470_1	1254432.SCE1572_37455	6.753e-232	732.0	COG3581@1|root,COG3581@2|Bacteria,1R7UD@1224|Proteobacteria,42W9G@68525|delta/epsilon subdivisions,2X3M8@28221|Deltaproteobacteria,2YWH5@29|Myxococcales	28221|Deltaproteobacteria	I	4 iron, 4 sulfur cluster binding	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2906470_5	91464.S7335_89	9.882e-116	384.0	COG2267@1|root,COG2267@2|Bacteria,1GH9H@1117|Cyanobacteria,1H3V0@1129|Synechococcus	1117|Cyanobacteria	I	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2906470_0	404589.Anae109_0189	0.0	1529.0	COG1924@1|root,COG3580@1|root,COG3581@1|root,COG1924@2|Bacteria,COG3580@2|Bacteria,COG3581@2|Bacteria,1PKG6@1224|Proteobacteria,42MY4@68525|delta/epsilon subdivisions,2WJFI@28221|Deltaproteobacteria,2YVGM@29|Myxococcales	28221|Deltaproteobacteria	I	CoA-substrate-specific enzyme activase	-	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG,DUF2229
HKD2_k127_2906470_7	269799.Gmet_0236	3.004e-24	108.0	COG0782@1|root,COG0782@2|Bacteria,1MYZ9@1224|Proteobacteria,42TAN@68525|delta/epsilon subdivisions,2WPSQ@28221|Deltaproteobacteria,43SJZ@69541|Desulfuromonadales	28221|Deltaproteobacteria	K	Transcription elongation factor, GreA/GreB, C-term	-	-	-	-	-	-	-	-	-	-	-	-	GreA_GreB
HKD2_k127_2906470_3	1192034.CAP_3357	4.282e-129	439.0	COG0515@1|root,COG0515@2|Bacteria,1Q38J@1224|Proteobacteria,438ZJ@68525|delta/epsilon subdivisions,2X44T@28221|Deltaproteobacteria,2YY98@29|Myxococcales	28221|Deltaproteobacteria	KLT	Protein kinase domain	masK	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HKD2_k127_2906470_6	693986.MOC_1739	2.412e-71	268.0	COG3831@1|root,COG3831@2|Bacteria,1QWC3@1224|Proteobacteria,2V1U1@28211|Alphaproteobacteria,1JXM9@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	Proposed nucleic acid binding domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4132,WGR
HKD2_k127_2906470_2	448385.sce1090	1.823e-177	567.0	COG0617@1|root,COG0617@2|Bacteria,1MU2X@1224|Proteobacteria,42N0S@68525|delta/epsilon subdivisions,2WMJK@28221|Deltaproteobacteria,2Z3CT@29|Myxococcales	28221|Deltaproteobacteria	H	tRNA nucleotidyltransferase domain 2 putative	-	-	2.7.7.19,2.7.7.72	ko:K00970,ko:K00974	ko03013,ko03018,map03013,map03018	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	HD,PolyA_pol,PolyA_pol_RNAbd,tRNA_NucTran2_2
HKD2_k127_2911159_4	1200557.JHWV01000005_gene1441	0.0001216	51.0	COG3620@1|root,COG3620@2|Bacteria,1V77U@1239|Firmicutes,4H4Q3@909932|Negativicutes	909932|Negativicutes	K	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
HKD2_k127_2911159_3	1457393.AZ09_08105	4.083e-22	96.0	COG1724@1|root,COG1724@2|Bacteria,1N7S3@1224|Proteobacteria,2UGAG@28211|Alphaproteobacteria,2JUDI@204441|Rhodospirillales	204441|Rhodospirillales	N	HicA toxin of bacterial toxin-antitoxin,	-	-	-	-	-	-	-	-	-	-	-	-	HicA_toxin
HKD2_k127_2911159_2	502025.Hoch_1414	1.202e-38	148.0	COG1917@1|root,COG1917@2|Bacteria,1RH1V@1224|Proteobacteria,42TDM@68525|delta/epsilon subdivisions,2WP8D@28221|Deltaproteobacteria,2YV8Y@29|Myxococcales	28221|Deltaproteobacteria	S	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	CMD,Cupin_2
HKD2_k127_2911159_1	1123248.KB893316_gene4659	1.652e-82	282.0	COG2249@1|root,COG2249@2|Bacteria,4NMQV@976|Bacteroidetes,1IRT3@117747|Sphingobacteriia	976|Bacteroidetes	S	Flavodoxin-like fold	-	-	1.6.5.2	ko:K00355	ko00130,ko01110,ko05200,ko05225,ko05418,map00130,map01110,map05200,map05225,map05418	-	R02964,R03643,R03816	RC00819	ko00000,ko00001,ko01000	-	-	-	Flavodoxin_2
HKD2_k127_2911159_0	448385.sce7747	4.313e-116	386.0	COG0639@1|root,COG0639@2|Bacteria,1NJ9V@1224|Proteobacteria,438VE@68525|delta/epsilon subdivisions,2X417@28221|Deltaproteobacteria,2YXWH@29|Myxococcales	28221|Deltaproteobacteria	T	Protein phosphatase 2A homologues, catalytic domain.	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
HKD2_k127_2911460_1	685727.REQ_02210	5.641e-46	170.0	COG2267@1|root,COG2267@2|Bacteria,2I94I@201174|Actinobacteria,4FYKH@85025|Nocardiaceae	201174|Actinobacteria	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
HKD2_k127_2911460_0	1254432.SCE1572_34165	7.124e-102	347.0	COG0515@1|root,COG0515@2|Bacteria	1254432.SCE1572_34165|-	KLT	protein kinase activity	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	-
HKD2_k127_2918405_0	404589.Anae109_4452	8.444e-286	889.0	COG3808@1|root,COG3808@2|Bacteria,1MUQ3@1224|Proteobacteria,42P3K@68525|delta/epsilon subdivisions,2WMB8@28221|Deltaproteobacteria,2YWYR@29|Myxococcales	28221|Deltaproteobacteria	C	Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
HKD2_k127_2918405_5	448385.sce2918	7.242e-50	190.0	COG1716@1|root,COG1716@2|Bacteria,1NEW5@1224|Proteobacteria,42VUF@68525|delta/epsilon subdivisions,2WRV9@28221|Deltaproteobacteria,2YV34@29|Myxococcales	28221|Deltaproteobacteria	T	FHA domain	-	-	-	-	-	-	-	-	-	-	-	-	FHA,TonB_C,Yop-YscD_cpl
HKD2_k127_2918405_2	1254432.SCE1572_15570	3.565e-112	380.0	COG0664@1|root,COG3264@1|root,COG0664@2|Bacteria,COG3264@2|Bacteria,1QX62@1224|Proteobacteria,42S57@68525|delta/epsilon subdivisions,2WNY0@28221|Deltaproteobacteria,2YVPP@29|Myxococcales	28221|Deltaproteobacteria	MT	Mechanosensitive ion channel	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel,cNMP_binding
HKD2_k127_2918405_4	1242864.D187_003015	2.656e-85	302.0	COG0642@1|root,COG2203@1|root,COG3829@1|root,COG2203@2|Bacteria,COG2205@2|Bacteria,COG3829@2|Bacteria,1NRP8@1224|Proteobacteria,42Z45@68525|delta/epsilon subdivisions,2WTWB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HAMP,HATPase_c,HisKA,PAS_4
HKD2_k127_2918405_7	1254432.SCE1572_12315	4.855e-39	169.0	COG0509@1|root,COG0509@2|Bacteria,1RGV7@1224|Proteobacteria,42RS9@68525|delta/epsilon subdivisions,2WP93@28221|Deltaproteobacteria,2Z1AT@29|Myxococcales	28221|Deltaproteobacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	gcvH	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
HKD2_k127_2918405_3	1136417.AZWE01000024_gene705	1.356e-85	323.0	COG3831@1|root,COG3831@2|Bacteria,2HIEQ@201174|Actinobacteria,4D9WJ@85008|Micromonosporales	201174|Actinobacteria	S	Domain of unknown function (DUF4132)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4132,WGR
HKD2_k127_2918405_1	1173028.ANKO01000112_gene4811	3.233e-154	497.0	COG1541@1|root,COG1541@2|Bacteria,1G21A@1117|Cyanobacteria,1H8DE@1150|Oscillatoriales	1117|Cyanobacteria	H	COGs COG1541 Coenzyme F390 synthetase	-	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	-
HKD2_k127_2918846_1	1254432.SCE1572_34845	1.203e-11	65.0	COG1806@1|root,COG1806@2|Bacteria,1MUHU@1224|Proteobacteria,42RV7@68525|delta/epsilon subdivisions,2WNZT@28221|Deltaproteobacteria,2YZ8A@29|Myxococcales	28221|Deltaproteobacteria	F	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation	-	-	2.7.11.33,2.7.4.28	ko:K09773	-	-	-	-	ko00000,ko01000	-	-	-	Kinase-PPPase
HKD2_k127_2918846_0	1254432.SCE1572_47480	1.789e-99	339.0	COG0515@1|root,COG0515@2|Bacteria	1254432.SCE1572_47480|-	KLT	protein kinase activity	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	-
HKD2_k127_2919673_11	443143.GM18_2448	1.284e-15	81.0	COG0636@1|root,COG0636@2|Bacteria,1N5D3@1224|Proteobacteria,438SF@68525|delta/epsilon subdivisions,2WY87@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM H transporting two-sector ATPase C subunit	-	-	-	ko:K02124	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_C
HKD2_k127_2919673_4	443143.GM18_2447	1.516e-80	293.0	COG1269@1|root,COG1269@2|Bacteria,1QGFB@1224|Proteobacteria,42UWC@68525|delta/epsilon subdivisions,2X5C3@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM V-type ATPase 116 kDa	-	-	-	ko:K02123	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	-
HKD2_k127_2919673_12	485917.Phep_2981	9.663e-07	61.0	COG3391@1|root,COG5492@1|root,COG3391@2|Bacteria,COG5492@2|Bacteria,4PMF3@976|Bacteroidetes,1IT6W@117747|Sphingobacteriia	976|Bacteroidetes	N	PFAM Bacterial Ig-like domain (group 2)	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,CHU_C,VCBS
HKD2_k127_2919673_0	215803.DB30_5875	4.891e-261	816.0	COG2304@1|root,COG2304@2|Bacteria,1Q3BR@1224|Proteobacteria,433ZK@68525|delta/epsilon subdivisions,2X48R@28221|Deltaproteobacteria,2YYI2@29|Myxococcales	28221|Deltaproteobacteria	S	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	VWA_2
HKD2_k127_2919673_7	1254432.SCE1572_31955	1.535e-51	195.0	COG2050@1|root,COG2050@2|Bacteria,1RHAN@1224|Proteobacteria,43157@68525|delta/epsilon subdivisions,2WWIW@28221|Deltaproteobacteria,2YVGQ@29|Myxococcales	28221|Deltaproteobacteria	Q	Domain of unknown function (DUF4442)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4442
HKD2_k127_2919673_6	1297742.A176_03859	4.974e-56	211.0	2A4YQ@1|root,30TKG@2|Bacteria,1PDGU@1224|Proteobacteria,4394M@68525|delta/epsilon subdivisions,2X4AR@28221|Deltaproteobacteria,2YYMK@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2919673_8	1242864.D187_010256	1.045e-38	159.0	2AN69@1|root,31D46@2|Bacteria,1QA6U@1224|Proteobacteria,434VC@68525|delta/epsilon subdivisions,2WZ6H@28221|Deltaproteobacteria,2Z1FB@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2919673_9	215803.DB30_4691	3.053e-20	99.0	2ANFJ@1|root,31DE8@2|Bacteria,1Q9UE@1224|Proteobacteria,434M8@68525|delta/epsilon subdivisions,2WYYS@28221|Deltaproteobacteria,2Z0Y6@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2919673_3	215803.DB30_5872	4.587e-83	289.0	COG0476@1|root,COG0476@2|Bacteria,1Q38H@1224|Proteobacteria,438ZG@68525|delta/epsilon subdivisions,2X44R@28221|Deltaproteobacteria,2YY93@29|Myxococcales	28221|Deltaproteobacteria	H	ThiF family	-	-	2.7.7.80	ko:K21029	ko04122,map04122	-	R07459	RC00043	ko00000,ko00001,ko01000	-	-	-	ThiF
HKD2_k127_2919673_2	1192034.CAP_5475	1.025e-83	296.0	COG0667@1|root,COG0667@2|Bacteria,1NWQE@1224|Proteobacteria,42ZW2@68525|delta/epsilon subdivisions,2WVDI@28221|Deltaproteobacteria,2YVXI@29|Myxococcales	28221|Deltaproteobacteria	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red,HEAT_2
HKD2_k127_2919673_5	1254432.SCE1572_16105	7.18e-58	231.0	2ANE2@1|root,31DCP@2|Bacteria,1QAIW@1224|Proteobacteria,43E1I@68525|delta/epsilon subdivisions,2WZFD@28221|Deltaproteobacteria,2Z20M@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2919673_1	1254432.SCE1572_01900	3.128e-183	632.0	COG2006@1|root,COG2006@2|Bacteria	2|Bacteria	U	4fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CBM9_1,CBM9_2,DUF362
HKD2_k127_2928307_0	621372.ACIH01000073_gene1718	7.387e-186	593.0	COG0495@1|root,COG0495@2|Bacteria,1TP0Y@1239|Firmicutes,4HAG1@91061|Bacilli,26QCH@186822|Paenibacillaceae	91061|Bacilli	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
HKD2_k127_2928307_3	656024.FsymDg_0596	2.882e-22	101.0	COG1848@1|root,COG1848@2|Bacteria,2GUVQ@201174|Actinobacteria	201174|Actinobacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2928307_1	1192034.CAP_7080	8.748e-116	385.0	COG3359@1|root,COG3359@2|Bacteria,1R5KG@1224|Proteobacteria,437YC@68525|delta/epsilon subdivisions,2X388@28221|Deltaproteobacteria,2YUT6@29|Myxococcales	28221|Deltaproteobacteria	L	RNase_H superfamily	-	-	-	ko:K07502	-	-	-	-	ko00000	-	-	-	RNase_H_2
HKD2_k127_2928307_2	1192034.CAP_1066	3.798e-57	221.0	COG3975@1|root,COG3975@2|Bacteria,1MYAB@1224|Proteobacteria,439JT@68525|delta/epsilon subdivisions,2X4WE@28221|Deltaproteobacteria,2YZR0@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2928307_4	1192034.CAP_4308	1.945e-11	70.0	COG1409@1|root,COG1409@2|Bacteria,1R4EJ@1224|Proteobacteria	1224|Proteobacteria	S	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
HKD2_k127_2938261_0	1144275.COCOR_06667	2.703e-100	329.0	COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,42MKB@68525|delta/epsilon subdivisions,2WJ4W@28221|Deltaproteobacteria,2YUFE@29|Myxococcales	28221|Deltaproteobacteria	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
HKD2_k127_2938261_5	502025.Hoch_2087	2.979e-08	66.0	2C9M1@1|root,2ZKV7@2|Bacteria,1R0N9@1224|Proteobacteria,43CYV@68525|delta/epsilon subdivisions,2X871@28221|Deltaproteobacteria,2Z1AK@29|Myxococcales	502025.Hoch_2087|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2938261_1	1254432.SCE1572_34340	1.667e-49	185.0	COG1607@1|root,COG1607@2|Bacteria,1RAEQ@1224|Proteobacteria,42SPA@68525|delta/epsilon subdivisions,2WPPE@28221|Deltaproteobacteria,2YVJ2@29|Myxococcales	28221|Deltaproteobacteria	I	Thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
HKD2_k127_2938261_3	1192034.CAP_0958	1.486e-16	94.0	COG1520@1|root,COG1520@2|Bacteria,1P31B@1224|Proteobacteria,42VDF@68525|delta/epsilon subdivisions,2WRBJ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	SBBP,fn3
HKD2_k127_2938261_2	448385.sce5915	4.79e-49	182.0	COG0017@1|root,COG0017@2|Bacteria,1MWFV@1224|Proteobacteria,42MJX@68525|delta/epsilon subdivisions,2WJDM@28221|Deltaproteobacteria,2YUKX@29|Myxococcales	28221|Deltaproteobacteria	J	asparaginyl-tRNA synthetase	asnS	-	6.1.1.22	ko:K01893	ko00970,map00970	M00359,M00360	R03648	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
HKD2_k127_295131_6	448385.sce6263	1.493e-13	74.0	COG3202@1|root,COG3202@2|Bacteria,1MVP5@1224|Proteobacteria,438CB@68525|delta/epsilon subdivisions,2X3MN@28221|Deltaproteobacteria,2YWIY@29|Myxococcales	28221|Deltaproteobacteria	C	ATP ADP translocase	-	-	-	ko:K03301	-	-	-	-	ko00000	2.A.12	-	-	-
HKD2_k127_295131_1	246197.MXAN_3125	1.223e-96	327.0	COG3214@1|root,COG3214@2|Bacteria,1R9AI@1224|Proteobacteria,43400@68525|delta/epsilon subdivisions,2X4C8@28221|Deltaproteobacteria,2YYQU@29|Myxococcales	28221|Deltaproteobacteria	S	Winged helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_42
HKD2_k127_295131_2	1192034.CAP_6921	2.186e-86	306.0	COG0515@1|root,COG0515@2|Bacteria,1PFJ6@1224|Proteobacteria,4340Z@68525|delta/epsilon subdivisions,2X4J2@28221|Deltaproteobacteria,2YZ45@29|Myxococcales	28221|Deltaproteobacteria	KLT	Protein kinase domain	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
HKD2_k127_295131_5	502025.Hoch_6691	3.578e-27	127.0	COG2010@1|root,COG2010@2|Bacteria,1PEGU@1224|Proteobacteria,434ZM@68525|delta/epsilon subdivisions,2X93H@28221|Deltaproteobacteria,2Z1PW@29|Myxococcales	28221|Deltaproteobacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_295131_7	1430440.MGMSRv2_1422	2.657e-11	69.0	COG4314@1|root,COG4314@2|Bacteria,1N3G0@1224|Proteobacteria	1224|Proteobacteria	C	lipoprotein involved in nitrous oxide reduction	-	-	-	ko:K19342	-	-	-	-	ko00000	-	-	-	NosL
HKD2_k127_295131_4	1304883.KI912532_gene2095	5.786e-47	179.0	COG1131@1|root,COG1131@2|Bacteria,1MXHE@1224|Proteobacteria,2VN8A@28216|Betaproteobacteria,2KVJR@206389|Rhodocyclales	206389|Rhodocyclales	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD2_k127_295131_3	518766.Rmar_2014	2.604e-68	259.0	COG3420@1|root,COG3420@2|Bacteria,4NEGT@976|Bacteroidetes,1FJC4@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	P	Domain present in carbohydrate binding proteins and sugar hydrolses	nosD	-	-	ko:K07218	-	-	-	-	ko00000	-	-	-	NosD
HKD2_k127_295131_0	926550.CLDAP_07150	4.35e-107	377.0	COG4263@1|root,COG4263@2|Bacteria,2G8B2@200795|Chloroflexi	200795|Chloroflexi	C	nitrous-oxide reductase activity	-	-	1.7.2.4	ko:K00376	ko00910,ko01120,map00910,map01120	M00529	R02804	RC02861	ko00000,ko00001,ko00002,ko01000	-	-	-	-
HKD2_k127_2991210_7	448385.sce8058	2.281e-24	108.0	29RQC@1|root,30CTT@2|Bacteria,1QTPW@1224|Proteobacteria,435D4@68525|delta/epsilon subdivisions,2WZQP@28221|Deltaproteobacteria,2Z2IY@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	PEGA
HKD2_k127_2991210_6	929712.KI912613_gene4216	2.917e-32	133.0	COG0742@1|root,COG0742@2|Bacteria,2GQ3G@201174|Actinobacteria,4CQ9U@84995|Rubrobacteria	84995|Rubrobacteria	L	Conserved hypothetical protein 95	-	-	-	-	-	-	-	-	-	-	-	-	Cons_hypoth95
HKD2_k127_2991210_9	1192034.CAP_0024	3.269e-06	57.0	COG0810@1|root,COG0810@2|Bacteria,1R65W@1224|Proteobacteria,42XJ0@68525|delta/epsilon subdivisions,2WT3A@28221|Deltaproteobacteria,2YYW2@29|Myxococcales	28221|Deltaproteobacteria	M	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins	-	-	-	-	-	-	-	-	-	-	-	-	TonB_C
HKD2_k127_2991210_5	1192034.CAP_4590	5.707e-63	233.0	COG2309@1|root,COG2309@2|Bacteria	2|Bacteria	E	aminopeptidase activity	-	-	-	ko:K19689	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M29
HKD2_k127_2991210_4	1192034.CAP_1419	3.265e-69	244.0	COG0101@1|root,COG0101@2|Bacteria,1MUYI@1224|Proteobacteria,42RTC@68525|delta/epsilon subdivisions,2WNQ6@28221|Deltaproteobacteria,2YVHB@29|Myxococcales	28221|Deltaproteobacteria	J	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs	truA	GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016853,GO:0016866,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360	5.4.99.12	ko:K06173	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PseudoU_synth_1
HKD2_k127_2991210_0	1192034.CAP_1420	7.455e-134	445.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,42NB6@68525|delta/epsilon subdivisions,2WIWE@28221|Deltaproteobacteria,2YYCB@29|Myxococcales	28221|Deltaproteobacteria	M	Domain present in PSD-95, Dlg, and ZO-1/2.	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
HKD2_k127_2991210_3	1242864.D187_001817	1.062e-85	302.0	COG2272@1|root,COG2272@2|Bacteria,1MVQZ@1224|Proteobacteria,42SQR@68525|delta/epsilon subdivisions,2WUZ8@28221|Deltaproteobacteria,2YUU5@29|Myxococcales	28221|Deltaproteobacteria	I	Belongs to the type-B carboxylesterase lipase family	-	-	-	ko:K03929	-	-	-	-	ko00000,ko01000	-	CE10	-	COesterase
HKD2_k127_2991210_1	448385.sce7198	9.085e-98	330.0	COG0451@1|root,COG0451@2|Bacteria,1MX2J@1224|Proteobacteria,42TZR@68525|delta/epsilon subdivisions,2WQAW@28221|Deltaproteobacteria,2YV9A@29|Myxococcales	28221|Deltaproteobacteria	M	NmrA-like family	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
HKD2_k127_2991210_8	1116232.AHBF01000007_gene1500	5.986e-18	97.0	COG1361@1|root,COG2373@1|root,COG4932@1|root,COG1361@2|Bacteria,COG2373@2|Bacteria,COG4932@2|Bacteria,2I8F1@201174|Actinobacteria	201174|Actinobacteria	M	cellulase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF11
HKD2_k127_2991210_2	448385.sce0030	2.862e-97	321.0	COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,42MMV@68525|delta/epsilon subdivisions,2WIZ4@28221|Deltaproteobacteria,2YU97@29|Myxococcales	28221|Deltaproteobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	Helicase_C,SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
HKD2_k127_2996740_3	1538295.JY96_20820	8.164e-129	416.0	COG0172@1|root,COG0172@2|Bacteria,1PHJG@1224|Proteobacteria,2VPIG@28216|Betaproteobacteria	28216|Betaproteobacteria	J	seryl-tRNA synthetase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2996740_4	1538295.JY96_20815	1.095e-100	347.0	2DBM2@1|root,2Z9WS@2|Bacteria,1Q3VU@1224|Proteobacteria,2VS9M@28216|Betaproteobacteria,1KP08@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Domain of unknown function (DUF1839)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1839
HKD2_k127_2996740_0	485913.Krac_2410	1.617e-221	713.0	COG3250@1|root,COG3250@2|Bacteria,2G5R6@200795|Chloroflexi	2|Bacteria	G	glycoside hydrolase family 2 sugar binding	manB3	-	3.2.1.25	ko:K01192	ko00511,ko04142,map00511,map04142	-	-	-	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_2
HKD2_k127_2996740_8	266264.Rmet_0334	3.468e-57	209.0	COG0500@1|root,COG2226@2|Bacteria,1NB07@1224|Proteobacteria,2VZ93@28216|Betaproteobacteria,1K4QV@119060|Burkholderiaceae	28216|Betaproteobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
HKD2_k127_2996740_6	876269.ARWA01000001_gene2831	4.598e-75	282.0	COG1073@1|root,COG1073@2|Bacteria,1RA55@1224|Proteobacteria,2U20W@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	polysaccharide biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6,Hydrolase_4,Polysacc_synt_3,Polysacc_synt_C
HKD2_k127_2996740_12	402777.KB235903_gene687	5.023e-39	166.0	COG3153@1|root,COG3153@2|Bacteria	2|Bacteria	S	transferase activity, transferring acyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10
HKD2_k127_2996740_9	1144275.COCOR_05704	3.193e-51	195.0	COG1073@1|root,COG1073@2|Bacteria,1MY4C@1224|Proteobacteria,42TB9@68525|delta/epsilon subdivisions,2WXEF@28221|Deltaproteobacteria,2YW3Y@29|Myxococcales	28221|Deltaproteobacteria	S	X-Pro dipeptidyl-peptidase (S15 family)	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Hydrolase_4
HKD2_k127_2996740_5	1144275.COCOR_08032	3.45e-80	286.0	COG2244@1|root,COG2244@2|Bacteria,1NI6U@1224|Proteobacteria,42VHT@68525|delta/epsilon subdivisions,2WRIK@28221|Deltaproteobacteria,2YYUI@29|Myxococcales	28221|Deltaproteobacteria	S	Polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt,Polysacc_synt_3,Polysacc_synt_C
HKD2_k127_2996740_11	246197.MXAN_7417	1.926e-41	159.0	COG1596@1|root,COG1596@2|Bacteria	2|Bacteria	M	polysaccharide export	-	-	-	ko:K01991	ko02026,map02026	-	-	-	ko00000,ko00001,ko02000	1.B.18	-	-	Poly_export,SLBB
HKD2_k127_2996740_7	378806.STAUR_7880	1.339e-64	239.0	COG3307@1|root,COG3307@2|Bacteria,1PDMS@1224|Proteobacteria,4399W@68525|delta/epsilon subdivisions,2X4HC@28221|Deltaproteobacteria,2YZ0Q@29|Myxococcales	28221|Deltaproteobacteria	M	-O-antigen	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2996740_1	1144275.COCOR_08057	6.871e-195	630.0	COG3534@1|root,COG3534@2|Bacteria,1RE68@1224|Proteobacteria,43C04@68525|delta/epsilon subdivisions,2X7AW@28221|Deltaproteobacteria,2YZ4E@29|Myxococcales	28221|Deltaproteobacteria	G	Glycoside hydrolase family 44	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_44
HKD2_k127_2996740_2	1254432.SCE1572_04890	3.072e-162	519.0	COG0477@1|root,COG2814@2|Bacteria,1QTX0@1224|Proteobacteria,42PT2@68525|delta/epsilon subdivisions,2WJ6Q@28221|Deltaproteobacteria,2YWF8@29|Myxococcales	28221|Deltaproteobacteria	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
HKD2_k127_2996740_10	215803.DB30_6918	1.156e-49	183.0	COG0477@1|root,COG0477@2|Bacteria,1RGPN@1224|Proteobacteria,43BMI@68525|delta/epsilon subdivisions,2X6ZQ@28221|Deltaproteobacteria,2Z3FD@29|Myxococcales	28221|Deltaproteobacteria	P	Major Facilitator Superfamily	-	-	-	ko:K03446	-	M00701	-	-	ko00000,ko00002,ko02000	2.A.1.3	-	-	MFS_1
HKD2_k127_3001689_5	1192034.CAP_7522	1.368e-31	131.0	2DHU7@1|root,300Z2@2|Bacteria,1Q940@1224|Proteobacteria,433U6@68525|delta/epsilon subdivisions,2X3GR@28221|Deltaproteobacteria,2YW0V@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	TPR_14
HKD2_k127_3001689_3	448385.sce3619	1.662e-79	283.0	COG1538@1|root,COG1538@2|Bacteria,1PDKT@1224|Proteobacteria,4398W@68525|delta/epsilon subdivisions,2X4G7@28221|Deltaproteobacteria,2YYYH@29|Myxococcales	28221|Deltaproteobacteria	MU	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
HKD2_k127_3001689_2	1192034.CAP_4613	1.816e-93	324.0	COG1538@1|root,COG1538@2|Bacteria,1QWWG@1224|Proteobacteria,42PD6@68525|delta/epsilon subdivisions,2WK6G@28221|Deltaproteobacteria,2Z1AQ@29|Myxococcales	28221|Deltaproteobacteria	MU	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
HKD2_k127_3001689_0	1297742.A176_04909	3.362e-130	436.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	two component, sigma54 specific, transcriptional regulator, Fis family	hsfA	-	-	ko:K07713,ko:K07714,ko:K07715	ko02020,ko02024,map02020,map02024	M00499,M00500,M00502	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD2_k127_3001689_1	448385.sce3935	1.338e-101	343.0	COG1194@1|root,COG1194@2|Bacteria,1MUD4@1224|Proteobacteria,42PDR@68525|delta/epsilon subdivisions,2WJ60@28221|Deltaproteobacteria,2YURG@29|Myxococcales	28221|Deltaproteobacteria	L	A G-specific	mutY	-	-	ko:K03575	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD,NUDIX_4
HKD2_k127_3001689_6	448385.sce2572	3.573e-26	112.0	2BWQN@1|root,347D7@2|Bacteria,1P0PN@1224|Proteobacteria,431R8@68525|delta/epsilon subdivisions,2WW8A@28221|Deltaproteobacteria,2Z20I@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3001689_7	378806.STAUR_3431	1.066e-14	87.0	COG1404@1|root,COG3227@1|root,COG3291@1|root,COG1404@2|Bacteria,COG3227@2|Bacteria,COG3291@2|Bacteria,1RFYD@1224|Proteobacteria,439R3@68525|delta/epsilon subdivisions,2X53R@28221|Deltaproteobacteria,2Z02M@29|Myxococcales	28221|Deltaproteobacteria	O	Bacterial pre-peptidase C-terminal domain	-	-	-	ko:K14645	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002,ko03110	-	-	-	PPC
HKD2_k127_3002273_1	448385.sce3607	2.429e-93	325.0	COG1376@1|root,COG1376@2|Bacteria,1NKBB@1224|Proteobacteria,432T9@68525|delta/epsilon subdivisions,2X2MM@28221|Deltaproteobacteria,2Z0G3@29|Myxococcales	28221|Deltaproteobacteria	S	L,D-transpeptidase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	YkuD
HKD2_k127_3002273_0	1172188.KB911822_gene763	2.165e-154	531.0	COG1835@1|root,COG2755@1|root,COG1835@2|Bacteria,COG2755@2|Bacteria,2GKI5@201174|Actinobacteria,4FJ6N@85021|Intrasporangiaceae	201174|Actinobacteria	I	Acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3,Lipase_GDSL_2
HKD2_k127_3002273_2	28564.XP_002477883.1	9.5e-27	123.0	KOG1218@1|root,KOG1218@2759|Eukaryota	2759|Eukaryota	S	negative regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment	-	-	-	-	-	-	-	-	-	-	-	-	EB,TIL
HKD2_k127_3011610_0	1254432.SCE1572_46020	1.179e-212	666.0	COG2987@1|root,COG2987@2|Bacteria,1MU4W@1224|Proteobacteria,42PUK@68525|delta/epsilon subdivisions,2WIN4@28221|Deltaproteobacteria,2YU7Y@29|Myxococcales	28221|Deltaproteobacteria	H	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate	hutU	-	4.2.1.49	ko:K01712	ko00340,ko01100,map00340,map01100	M00045	R02914	RC00804	ko00000,ko00001,ko00002,ko01000	-	-	-	Urocanase,Urocanase_C,Urocanase_N
HKD2_k127_3011610_2	448385.sce7479	2.054e-53	192.0	28ZS2@1|root,2ZMGV@2|Bacteria,1Q9PN@1224|Proteobacteria,434I5@68525|delta/epsilon subdivisions,2X8WM@28221|Deltaproteobacteria,2Z0QQ@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	CAP
HKD2_k127_3011610_1	448385.sce7577	1.871e-80	271.0	COG1408@1|root,COG1408@2|Bacteria,1MUH5@1224|Proteobacteria,42N75@68525|delta/epsilon subdivisions,2WKJY@28221|Deltaproteobacteria,2Z2YT@29|Myxococcales	28221|Deltaproteobacteria	S	Calcineurin-like phosphoesterase	-	-	-	ko:K07098	-	-	-	-	ko00000	-	-	-	Metallophos
HKD2_k127_3016826_0	1192034.CAP_5012	3.353e-119	388.0	COG2086@1|root,COG2086@2|Bacteria,1MVH6@1224|Proteobacteria,42PYM@68525|delta/epsilon subdivisions,2WJ37@28221|Deltaproteobacteria,2Z31S@29|Myxococcales	28221|Deltaproteobacteria	C	Electron transfer flavoprotein	-	-	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
HKD2_k127_3016826_1	448385.sce0625	9.573e-115	385.0	COG2025@1|root,COG2025@2|Bacteria,1MUFI@1224|Proteobacteria,42M3T@68525|delta/epsilon subdivisions,2WIV8@28221|Deltaproteobacteria,2YUPZ@29|Myxococcales	28221|Deltaproteobacteria	C	Electron transfer flavoprotein	etfA	-	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	-	ETF,ETF_alpha
HKD2_k127_3016826_3	1121946.AUAX01000012_gene6532	4.389e-05	56.0	COG5001@1|root,COG5001@2|Bacteria,2GIZF@201174|Actinobacteria,4D96D@85008|Micromonosporales	201174|Actinobacteria	T	Diguanylate cyclase phosphodiesterase with PAS	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS,PAS_4,PAS_9
HKD2_k127_3016826_2	1396418.BATQ01000129_gene4821	4.314e-08	55.0	COG2812@1|root,COG2812@2|Bacteria,46SGC@74201|Verrucomicrobia,2ITGI@203494|Verrucomicrobiae	203494|Verrucomicrobiae	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity	dnaX	-	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNA_pol3_gamma3
HKD2_k127_3026652_0	1254432.SCE1572_06940	2.1e-157	499.0	COG1217@1|root,COG1217@2|Bacteria,1MV5Q@1224|Proteobacteria,42M3S@68525|delta/epsilon subdivisions,2WJVZ@28221|Deltaproteobacteria,2YU94@29|Myxococcales	28221|Deltaproteobacteria	T	GTP-binding protein	typA	-	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2
HKD2_k127_3026652_9	1254432.SCE1572_25350	7.847e-20	104.0	COG0457@1|root,COG0457@2|Bacteria	1254432.SCE1572_25350|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3026652_11	28564.XP_002477883.1	6.562e-14	78.0	KOG1218@1|root,KOG1218@2759|Eukaryota	2759|Eukaryota	S	negative regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment	-	-	-	-	-	-	-	-	-	-	-	-	EB,TIL
HKD2_k127_3026652_7	1192034.CAP_1251	6.879e-32	129.0	COG0545@1|root,COG0545@2|Bacteria,1RDA1@1224|Proteobacteria	1224|Proteobacteria	O	Peptidyl-prolyl cis-trans	fbp	-	5.2.1.8	ko:K01802,ko:K03772	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	FKBP_C,Rhodanese
HKD2_k127_3026652_1	1192034.CAP_7938	2.001e-123	417.0	COG1376@1|root,COG1376@2|Bacteria,1NKBB@1224|Proteobacteria,432T9@68525|delta/epsilon subdivisions,2X2MM@28221|Deltaproteobacteria,2Z0G3@29|Myxococcales	28221|Deltaproteobacteria	S	L,D-transpeptidase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	YkuD
HKD2_k127_3026652_10	1384049.CD29_02860	1.42e-17	85.0	2AP0Q@1|root,31E1U@2|Bacteria,1TZQR@1239|Firmicutes,4I901@91061|Bacilli,3IZP4@400634|Lysinibacillus	91061|Bacilli	S	GRAM domain	-	-	-	-	-	-	-	-	-	-	-	-	GRAM
HKD2_k127_3026652_2	448385.sce3608	3.018e-118	389.0	COG0457@1|root,COG0457@2|Bacteria,1QX47@1224|Proteobacteria,42Y0X@68525|delta/epsilon subdivisions,2WT7V@28221|Deltaproteobacteria,2YW72@29|Myxococcales	28221|Deltaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_19,TPR_2,Zincin_1
HKD2_k127_3026652_5	502025.Hoch_2165	9.26e-68	259.0	COG0645@1|root,COG2187@1|root,COG0645@2|Bacteria,COG2187@2|Bacteria,1MU9M@1224|Proteobacteria,42NEZ@68525|delta/epsilon subdivisions,2WJ5R@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	AAA domain	-	-	-	ko:K07028	-	-	-	-	ko00000	-	-	-	AAA_33,APH
HKD2_k127_3026652_6	1150398.JIBJ01000013_gene2549	2.742e-40	162.0	COG3511@1|root,COG3511@2|Bacteria	2|Bacteria	M	phospholipase C	-	-	3.1.3.64	ko:K21302	ko00562,ko01100,ko05152,map00562,map01100,map05152	-	-	-	ko00000,ko00001,ko01000	-	-	-	Phosphoesterase
HKD2_k127_3026652_4	448385.sce6263	4.588e-85	314.0	COG3202@1|root,COG3202@2|Bacteria,1MVP5@1224|Proteobacteria,438CB@68525|delta/epsilon subdivisions,2X3MN@28221|Deltaproteobacteria,2YWIY@29|Myxococcales	28221|Deltaproteobacteria	C	ATP ADP translocase	-	-	-	ko:K03301	-	-	-	-	ko00000	2.A.12	-	-	-
HKD2_k127_3052556_0	1192034.CAP_5696	5.766e-139	457.0	COG2303@1|root,COG2303@2|Bacteria,1P9UF@1224|Proteobacteria,43A4M@68525|delta/epsilon subdivisions,2WYKE@28221|Deltaproteobacteria,2Z0NN@29|Myxococcales	28221|Deltaproteobacteria	E	GMC oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GMC_oxred_C,GMC_oxred_N
HKD2_k127_3052556_2	1333998.M2A_2841	4.857e-08	57.0	293C9@1|root,2ZQUV@2|Bacteria,1P74T@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3069975_0	1254432.SCE1572_25705	1.088e-107	352.0	COG2022@1|root,COG2022@2|Bacteria,1N0N5@1224|Proteobacteria,42MNC@68525|delta/epsilon subdivisions,2WIUI@28221|Deltaproteobacteria,2YUEF@29|Myxococcales	28221|Deltaproteobacteria	H	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S	thiG	GO:0003674,GO:0003824,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.8.1.10	ko:K03149	ko00730,ko01100,map00730,map01100	-	R10247	RC03096,RC03097,RC03461	ko00000,ko00001,ko01000	-	-	-	ThiG
HKD2_k127_3069975_1	1144275.COCOR_07247	5.553e-40	164.0	COG1988@1|root,COG1988@2|Bacteria	2|Bacteria	NT	membrane-bound metal-dependent	ybcI	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K07038	-	-	-	-	ko00000	-	-	-	YdjM
HKD2_k127_3069975_2	290397.Adeh_2612	4.64e-19	98.0	COG1560@1|root,COG1560@2|Bacteria,1MVNI@1224|Proteobacteria,42N6U@68525|delta/epsilon subdivisions,2WQ3X@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Lipid A biosynthesis acyltransferase	msbB	-	2.3.1.241	ko:K02517	ko00540,ko01100,map00540,map01100	M00060	R05146	RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Lip_A_acyltrans
HKD2_k127_3069975_3	448385.sce3138	3.023e-14	75.0	2DMA1@1|root,32B1Q@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3076978_2	1192034.CAP_0380	1.797e-70	240.0	COG2131@1|root,COG2131@2|Bacteria,1RD1P@1224|Proteobacteria,42RHI@68525|delta/epsilon subdivisions,2WNGV@28221|Deltaproteobacteria,2YV1R@29|Myxococcales	28221|Deltaproteobacteria	F	deaminase	comEB	-	3.5.4.12	ko:K01493	ko00240,ko01100,map00240,map01100	M00429	R01663	RC00074	ko00000,ko00001,ko00002,ko01000,ko02044	-	-	-	dCMP_cyt_deam_1
HKD2_k127_3076978_0	448385.sce8615	4.158e-102	338.0	COG0745@1|root,COG0745@2|Bacteria,1PG0S@1224|Proteobacteria,4391F@68525|delta/epsilon subdivisions,2X46V@28221|Deltaproteobacteria,2YYDF@29|Myxococcales	28221|Deltaproteobacteria	K	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
HKD2_k127_3076978_3	1336243.JAEA01000002_gene2812	4.644e-55	208.0	COG1181@1|root,COG1181@2|Bacteria,1MUTB@1224|Proteobacteria,2TREC@28211|Alphaproteobacteria,1JSSH@119045|Methylobacteriaceae	28211|Alphaproteobacteria	M	Cell wall formation	ddl	-	1.3.1.98,6.3.2.4	ko:K00075,ko:K01921	ko00473,ko00520,ko00550,ko01100,ko01502,map00473,map00520,map00550,map01100,map01502	-	R01150,R03191,R03192	RC00064,RC00141,RC02639	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C,Dala_Dala_lig_N
HKD2_k127_3076978_4	448385.sce2574	2.678e-30	122.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,42NY2@68525|delta/epsilon subdivisions,2WJKQ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	KLT	SMART serine threonine protein kinase	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	DUF1566,Pkinase
HKD2_k127_3085161_2	1254432.SCE1572_27170	5.459e-20	95.0	COG0568@1|root,COG0568@2|Bacteria,1MVNJ@1224|Proteobacteria,42N2S@68525|delta/epsilon subdivisions,2WJ0E@28221|Deltaproteobacteria,2YUHI@29|Myxococcales	28221|Deltaproteobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	rpoD	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_ner,Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
HKD2_k127_3085161_0	1254432.SCE1572_27165	7.664e-166	545.0	COG0358@1|root,COG0358@2|Bacteria,1MUHC@1224|Proteobacteria,42MDZ@68525|delta/epsilon subdivisions,2WJ9Y@28221|Deltaproteobacteria,2YUT2@29|Myxococcales	28221|Deltaproteobacteria	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2
HKD2_k127_3085161_1	313606.M23134_00497	6.125e-25	115.0	2DFQD@1|root,2ZSNM@2|Bacteria,4P7GE@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3085161_4	1248232.BANQ01000131_gene1113	1.75e-08	65.0	COG1879@1|root,COG4547@1|root,COG1879@2|Bacteria,COG4547@2|Bacteria,1R23C@1224|Proteobacteria,1T5FT@1236|Gammaproteobacteria,1Y3BP@135623|Vibrionales	135623|Vibrionales	GH	Putative Ig domain	-	-	-	-	-	-	-	-	-	-	-	-	He_PIG,Peptidase_M66
HKD2_k127_3085161_3	1232410.KI421422_gene2049	4.863e-17	88.0	COG0055@1|root,COG0055@2|Bacteria,1MUFU@1224|Proteobacteria,42KZA@68525|delta/epsilon subdivisions,2WJ1V@28221|Deltaproteobacteria,43S0H@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits	atpD	-	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_N
HKD2_k127_3094593_0	448385.sce5749	1.751e-14	82.0	COG0515@1|root,COG0515@2|Bacteria	448385.sce5749|-	KLT	protein kinase activity	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	-
HKD2_k127_310574_1	1192034.CAP_3455	5.644e-10	66.0	COG3386@1|root,COG3386@2|Bacteria,1NFEJ@1224|Proteobacteria,43BX0@68525|delta/epsilon subdivisions,2X77S@28221|Deltaproteobacteria,2YVY8@29|Myxococcales	28221|Deltaproteobacteria	G	PFAM SMP-30 Gluconolaconase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_310574_0	1121920.AUAU01000008_gene1595	5.698e-19	88.0	2DBW6@1|root,2ZBEP@2|Bacteria,3Y9F1@57723|Acidobacteria	2|Bacteria	C	TIGRFAM decaheme c-type cytochrome, OmcA MtrC family	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_CIII,Cytochrome_C7
HKD2_k127_3111867_3	448385.sce2470	4.823e-52	187.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,42Q67@68525|delta/epsilon subdivisions,2WKZ1@28221|Deltaproteobacteria,2YUQ6@29|Myxococcales	28221|Deltaproteobacteria	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	AAA_16,Pkinase,TPR_12,zinc_ribbon_2
HKD2_k127_3111867_1	1192034.CAP_3370	4.365e-111	368.0	COG4850@1|root,COG4850@2|Bacteria,1NYAE@1224|Proteobacteria,430HM@68525|delta/epsilon subdivisions,2WW1X@28221|Deltaproteobacteria,2YUT1@29|Myxococcales	28221|Deltaproteobacteria	S	conserved protein (DUF2183)	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3111867_0	1254432.SCE1572_14825	9.529e-130	427.0	COG0141@1|root,COG0141@2|Bacteria,1MUUF@1224|Proteobacteria,42M3R@68525|delta/epsilon subdivisions,2WJGT@28221|Deltaproteobacteria,2YTXD@29|Myxococcales	28221|Deltaproteobacteria	E	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine	hisD	GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.1.1.23	ko:K00013	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01158,R01163,R03012	RC00099,RC00242,RC00463	ko00000,ko00001,ko00002,ko01000	-	-	-	Histidinol_dh
HKD2_k127_3121437_0	1173027.Mic7113_2905	0.0	1184.0	COG0403@1|root,COG1003@1|root,COG0403@2|Bacteria,COG1003@2|Bacteria,1G1HW@1117|Cyanobacteria,1H6Y0@1150|Oscillatoriales	1117|Cyanobacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvP	-	1.4.4.2	ko:K00281	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko00002,ko01000	-	-	-	GDC-P
HKD2_k127_3121437_2	391625.PPSIR1_30631	1.276e-49	198.0	COG1719@1|root,COG1719@2|Bacteria	2|Bacteria	KT	4-vinyl reductase, 4VR	-	-	3.1.3.16	ko:K06382,ko:K07013	-	-	-	-	ko00000,ko01000	-	-	-	HATPase_c,SpoIIE,V4R
HKD2_k127_3121437_1	1210884.HG799463_gene9317	1.035e-95	336.0	COG4191@1|root,COG4191@2|Bacteria,2IWUM@203682|Planctomycetes	203682|Planctomycetes	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
HKD2_k127_3121437_3	1192034.CAP_1905	3.237e-46	172.0	COG0515@1|root,COG2110@1|root,COG0515@2|Bacteria,COG2110@2|Bacteria	2|Bacteria	P	phosphatase homologous to the C-terminal domain of histone macroH2A1	tfaE	GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Caudo_TAP,Macro
HKD2_k127_3127062_3	483219.LILAB_32080	1.756e-18	95.0	COG0542@1|root,COG0542@2|Bacteria,1MURH@1224|Proteobacteria,42M9S@68525|delta/epsilon subdivisions,2WJSZ@28221|Deltaproteobacteria,2Z2Y0@29|Myxococcales	28221|Deltaproteobacteria	O	C-terminal, D2-small domain, of ClpB protein	-	-	-	ko:K03696	ko01100,map01100	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small
HKD2_k127_3127062_1	45157.CMD146CT	8.476e-45	169.0	KOG1639@1|root,KOG1639@2759|Eukaryota	2759|Eukaryota	S	very-long-chain enoyl-CoA reductase activity	TSC13	GO:0000038,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005783,GO:0005789,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0012505,GO:0016020,GO:0016021,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0016631,GO:0019752,GO:0030497,GO:0031224,GO:0031984,GO:0032787,GO:0042175,GO:0042761,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044425,GO:0044432,GO:0044444,GO:0044446,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:0072330,GO:0098827,GO:1901576	1.3.1.93,3.6.3.44	ko:K05658,ko:K10258	ko00062,ko01040,ko01110,ko01212,ko02010,ko04976,ko05206,ko05226,map00062,map01040,map01110,map01212,map02010,map04976,map05206,map05226	M00415	R07761,R09449,R10828	RC00052,RC00120	ko00000,ko00001,ko00002,ko01000,ko01004,ko02000,ko04090,ko04147	3.A.1.201	-	-	Steroid_dh
HKD2_k127_3127062_0	1192034.CAP_4725	4.531e-201	651.0	COG0457@1|root,COG0515@1|root,COG5616@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG5616@2|Bacteria,1MV1P@1224|Proteobacteria,42PPB@68525|delta/epsilon subdivisions,2X5YN@28221|Deltaproteobacteria,2YUEJ@29|Myxococcales	28221|Deltaproteobacteria	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_10,TPR_12
HKD2_k127_3127062_2	1192034.CAP_8038	2.694e-32	137.0	COG0457@1|root,COG0526@1|root,COG0457@2|Bacteria,COG0526@2|Bacteria,1QYGQ@1224|Proteobacteria,43CCZ@68525|delta/epsilon subdivisions,2X7NU@28221|Deltaproteobacteria,2Z3H8@29|Myxococcales	28221|Deltaproteobacteria	CO	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_7
HKD2_k127_313859_1	762948.HMPREF0733_10221	2.622e-17	94.0	COG0596@1|root,COG0596@2|Bacteria,2I2VI@201174|Actinobacteria	201174|Actinobacteria	S	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
HKD2_k127_313859_0	247156.NFA_11840	5.91e-47	174.0	COG4681@1|root,COG4681@2|Bacteria,2GKN7@201174|Actinobacteria,4FUU1@85025|Nocardiaceae	201174|Actinobacteria	S	YaeQ	-	-	-	-	-	-	-	-	-	-	-	-	YaeQ
HKD2_k127_313859_2	1214242.B446_15290	1.277e-06	56.0	COG0457@1|root,COG0457@2|Bacteria,2GJD3@201174|Actinobacteria	201174|Actinobacteria	O	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_19,TPR_2,TPR_8
HKD2_k127_316001_1	1242864.D187_004198	5.864e-40	160.0	COG0726@1|root,COG0726@2|Bacteria,1R881@1224|Proteobacteria	1224|Proteobacteria	G	polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
HKD2_k127_316001_2	1254432.SCE1572_01805	1.254e-38	154.0	COG1266@1|root,COG1266@2|Bacteria,1MWXT@1224|Proteobacteria,42XZG@68525|delta/epsilon subdivisions,2WSV7@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
HKD2_k127_316001_3	1463879.JOHP01000061_gene2709	2.291e-28	121.0	2BFM0@1|root,329F8@2|Bacteria,2ISYC@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_316001_5	28564.XP_002477883.1	5.306e-18	96.0	KOG1218@1|root,KOG1218@2759|Eukaryota	2759|Eukaryota	S	negative regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment	-	-	-	-	-	-	-	-	-	-	-	-	EB,TIL
HKD2_k127_316001_0	710686.Mycsm_01038	6.222e-105	354.0	COG1063@1|root,COG1063@2|Bacteria,2IBQC@201174|Actinobacteria,23300@1762|Mycobacteriaceae	201174|Actinobacteria	E	Alcohol dehydrogenase GroES-like domain	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
HKD2_k127_316001_4	1041522.MCOL_V216624	2.115e-22	103.0	COG1063@1|root,COG1063@2|Bacteria,2IBQC@201174|Actinobacteria,23300@1762|Mycobacteriaceae	201174|Actinobacteria	E	Alcohol dehydrogenase GroES-like domain	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
HKD2_k127_3163703_0	448385.sce6082	1.855e-202	663.0	COG2986@1|root,COG2986@2|Bacteria,1MU6K@1224|Proteobacteria,42MST@68525|delta/epsilon subdivisions,2WKAN@28221|Deltaproteobacteria,2YUFR@29|Myxococcales	28221|Deltaproteobacteria	E	Histidine ammonia-lyase	hutH	-	4.3.1.3	ko:K01745	ko00340,ko01100,map00340,map01100	M00045	R01168	RC00361	ko00000,ko00001,ko00002,ko01000	-	-	-	Lyase_aromatic
HKD2_k127_3163703_2	1207076.ALAT01000180_gene2204	8.063e-16	91.0	COG2755@1|root,COG2755@2|Bacteria	2|Bacteria	E	lipolytic protein G-D-S-L family	-	-	-	ko:K00612	-	-	-	-	ko00000,ko01000	-	-	-	Lipase_GDSL_2
HKD2_k127_3167717_4	1122939.ATUD01000006_gene1760	1.051e-13	77.0	COG2186@1|root,COG2186@2|Bacteria,2I90D@201174|Actinobacteria,4CSXX@84995|Rubrobacteria	84995|Rubrobacteria	K	FCD	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
HKD2_k127_3167717_0	448385.sce2044	5.023e-113	378.0	COG2008@1|root,COG2008@2|Bacteria,1MWCR@1224|Proteobacteria,42MZS@68525|delta/epsilon subdivisions,2WIQP@28221|Deltaproteobacteria,2YUBW@29|Myxococcales	28221|Deltaproteobacteria	E	Threonine aldolase	ltaA	-	4.1.2.48	ko:K01620	ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230	-	R00751,R06171	RC00312,RC00372	ko00000,ko00001,ko01000	-	-	-	Beta_elim_lyase
HKD2_k127_3167717_2	1192034.CAP_7895	1.19e-38	166.0	2BP52@1|root,32HVW@2|Bacteria,1QAR1@1224|Proteobacteria,4358W@68525|delta/epsilon subdivisions,2WZK1@28221|Deltaproteobacteria,2Z2AG@29|Myxococcales	28221|Deltaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_6
HKD2_k127_3169164_2	448385.sce7094	8.11e-72	244.0	COG0448@1|root,COG0448@2|Bacteria,1MVTC@1224|Proteobacteria,42NGK@68525|delta/epsilon subdivisions,2WM29@28221|Deltaproteobacteria,2YU1M@29|Myxococcales	28221|Deltaproteobacteria	H	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans	glgC	-	2.7.7.27	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	M00565	R00948	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2768	NTP_transferase
HKD2_k127_3169164_1	1254432.SCE1572_41390	3.674e-73	254.0	COG0639@1|root,COG0639@2|Bacteria,1RD8M@1224|Proteobacteria,42RQP@68525|delta/epsilon subdivisions,2WNQ7@28221|Deltaproteobacteria,2YVU0@29|Myxococcales	28221|Deltaproteobacteria	T	Diadenosine tetraphosphatase and related serine threonine protein phosphatases	-	-	3.1.3.16	ko:K07313	-	-	-	-	ko00000,ko01000	-	-	-	Metallophos,Metallophos_2
HKD2_k127_3169164_4	1254432.SCE1572_17875	1.149e-53	217.0	COG0515@1|root,COG2114@1|root,COG3899@1|root,COG0515@2|Bacteria,COG2114@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,42NXT@68525|delta/epsilon subdivisions,2WIZ3@28221|Deltaproteobacteria,2YWHV@29|Myxococcales	28221|Deltaproteobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,DZR,Guanylate_cyc,Pkinase,TPR_12
HKD2_k127_3169164_7	1278073.MYSTI_05233	3.407e-11	76.0	COG0457@1|root,COG0457@2|Bacteria	1278073.MYSTI_05233|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3169164_3	1254432.SCE1572_41385	2.473e-67	252.0	COG2264@1|root,COG2264@2|Bacteria,1MUPC@1224|Proteobacteria,42NSS@68525|delta/epsilon subdivisions,2WMUT@28221|Deltaproteobacteria,2YVRX@29|Myxococcales	28221|Deltaproteobacteria	J	Methylates ribosomal protein L11	prmA	-	-	ko:K02687	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PrmA
HKD2_k127_3169164_5	448385.sce7091	1.231e-45	184.0	COG1385@1|root,COG1385@2|Bacteria,1MXCU@1224|Proteobacteria,42R1A@68525|delta/epsilon subdivisions,2WMV6@28221|Deltaproteobacteria,2YVVD@29|Myxococcales	28221|Deltaproteobacteria	J	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit	rsmE	-	2.1.1.193	ko:K09761	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_RNA
HKD2_k127_3169164_6	903818.KI912268_gene1848	2.801e-23	112.0	2CI12@1|root,338T1@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3169164_0	1254432.SCE1572_17805	2.223e-124	404.0	2AJ4S@1|root,319P9@2|Bacteria,1Q3EK@1224|Proteobacteria,4396C@68525|delta/epsilon subdivisions,2X4D3@28221|Deltaproteobacteria,2Z03F@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3191825_5	748247.AZKH_2764	0.0001078	46.0	COG1355@1|root,COG1355@2|Bacteria,1MXK5@1224|Proteobacteria,2VKXP@28216|Betaproteobacteria,2KVTT@206389|Rhodocyclales	206389|Rhodocyclales	S	Belongs to the MEMO1 family	-	-	-	ko:K06990	-	-	-	-	ko00000,ko04812	-	-	-	Memo
HKD2_k127_3191825_2	521011.Mpal_2782	1.692e-38	160.0	COG1576@1|root,arCOG00502@2157|Archaea,2XZ8Z@28890|Euryarchaeota	28890|Euryarchaeota	J	beta-lactamase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
HKD2_k127_3191825_3	1254432.SCE1572_35050	2.017e-34	151.0	COG1520@1|root,COG1520@2|Bacteria	2|Bacteria	S	amino acid activation for nonribosomal peptide biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2
HKD2_k127_3191825_1	1192034.CAP_2499	3.247e-46	169.0	COG0316@1|root,COG0316@2|Bacteria,1RHCW@1224|Proteobacteria,431E6@68525|delta/epsilon subdivisions,2WWGA@28221|Deltaproteobacteria,2YVXB@29|Myxococcales	28221|Deltaproteobacteria	S	Belongs to the HesB IscA family	-	-	-	ko:K13628	-	-	-	-	ko00000,ko03016	-	-	-	Fe-S_biosyn
HKD2_k127_320225_2	1192034.CAP_3057	4.709e-52	198.0	COG1729@1|root,COG1729@2|Bacteria	2|Bacteria	S	protein trimerization	-	-	-	-	-	-	-	-	-	-	-	-	PEGA,TPR_16,TPR_6,TPR_8
HKD2_k127_320225_3	392499.Swit_1138	8.543e-25	114.0	COG3000@1|root,COG3000@2|Bacteria,1MW5G@1224|Proteobacteria,2TU63@28211|Alphaproteobacteria,2K016@204457|Sphingomonadales	204457|Sphingomonadales	I	Fatty acid hydroxylase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	FA_hydroxylase
HKD2_k127_320225_0	1254432.SCE1572_08540	1.964e-124	414.0	COG0534@1|root,COG0534@2|Bacteria,1MUAM@1224|Proteobacteria,42P67@68525|delta/epsilon subdivisions,2WJP7@28221|Deltaproteobacteria,2Z34G@29|Myxococcales	28221|Deltaproteobacteria	V	MatE	-	-	-	ko:K03327	-	-	-	-	ko00000,ko02000	2.A.66.1	-	-	MatE
HKD2_k127_320225_1	1254432.SCE1572_42390	3.022e-119	395.0	COG0681@1|root,COG0711@1|root,COG0681@2|Bacteria,COG0711@2|Bacteria,1MXUF@1224|Proteobacteria,42NJE@68525|delta/epsilon subdivisions,2WKMA@28221|Deltaproteobacteria,2YV8J@29|Myxococcales	28221|Deltaproteobacteria	U	Belongs to the peptidase S26 family	lepB	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24
HKD2_k127_3206448_2	1430440.MGMSRv2_1430	1.871e-29	118.0	COG4263@1|root,COG4263@2|Bacteria,1MVIH@1224|Proteobacteria,2TTB5@28211|Alphaproteobacteria,2JR4S@204441|Rhodospirillales	204441|Rhodospirillales	C	Nitrous-oxide reductase is part of a bacterial respiratory system which is activated under anaerobic conditions in the presence of nitrate or nitrous oxide	nosZ	-	1.7.2.4	ko:K00376	ko00910,ko01120,map00910,map01120	M00529	R02804	RC02861	ko00000,ko00001,ko00002,ko01000	-	-	-	Cupredoxin_1
HKD2_k127_3206448_0	273121.WS0919	7.065e-78	281.0	COG3420@1|root,COG3420@2|Bacteria,1MVCD@1224|Proteobacteria,42NVZ@68525|delta/epsilon subdivisions,2YN9J@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	P	periplasmic copper-binding protein NosD	nosD	-	-	ko:K07218	-	-	-	-	ko00000	-	-	-	NosD
HKD2_k127_3206448_1	1304883.KI912532_gene2095	1.137e-32	137.0	COG1131@1|root,COG1131@2|Bacteria,1MXHE@1224|Proteobacteria,2VN8A@28216|Betaproteobacteria,2KVJR@206389|Rhodocyclales	206389|Rhodocyclales	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD2_k127_320649_3	909663.KI867150_gene2837	1.646e-08	58.0	COG1396@1|root,COG1396@2|Bacteria,1NGM7@1224|Proteobacteria,42X7S@68525|delta/epsilon subdivisions,2WSVH@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	PFAM Helix-turn-helix	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
HKD2_k127_320649_0	448385.sce2007	8.059e-44	171.0	COG1075@1|root,COG1075@2|Bacteria	2|Bacteria	KLT	acetyltransferases and hydrolases with the alpha beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6,PGAP1
HKD2_k127_320649_1	215803.DB30_6696	1.187e-37	145.0	COG0824@1|root,COG0824@2|Bacteria,1RI3X@1224|Proteobacteria,42SW5@68525|delta/epsilon subdivisions,2WW97@28221|Deltaproteobacteria,2Z1TM@29|Myxococcales	28221|Deltaproteobacteria	S	Acyl-ACP thioesterase	-	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	Acyl-ACP_TE
HKD2_k127_320649_2	448385.sce2006	2.59e-12	71.0	COG1287@1|root,COG1287@2|Bacteria	2|Bacteria	S	oligosaccharyl transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3207542_2	1142394.PSMK_29960	3.526e-14	79.0	COG0500@1|root,COG0500@2|Bacteria,2J1BB@203682|Planctomycetes	203682|Planctomycetes	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3207542_0	1192034.CAP_5438	3.465e-70	248.0	COG0321@1|root,COG0321@2|Bacteria,1MU6A@1224|Proteobacteria,42RIC@68525|delta/epsilon subdivisions,2WPRF@28221|Deltaproteobacteria,2YVCE@29|Myxococcales	28221|Deltaproteobacteria	H	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate	lipB	-	2.3.1.181	ko:K03801	ko00785,ko01100,map00785,map01100	-	R07766,R07769	RC00039,RC00992,RC02867	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB,NUDIX
HKD2_k127_3207542_1	1192034.CAP_7478	1.121e-48	174.0	COG0516@1|root,COG0516@2|Bacteria,1MUJM@1224|Proteobacteria,42M2M@68525|delta/epsilon subdivisions,2WJ5H@28221|Deltaproteobacteria,2YUG2@29|Myxococcales	28221|Deltaproteobacteria	F	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth	guaB	-	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,IMPDH,NMO
HKD2_k127_321306_1	448385.sce5470	1.386e-60	226.0	COG0515@1|root,COG0515@2|Bacteria	448385.sce5470|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_321306_0	448385.sce7428	8.621e-98	334.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,42Q67@68525|delta/epsilon subdivisions,2WKZ1@28221|Deltaproteobacteria,2YWMB@29|Myxococcales	28221|Deltaproteobacteria	KLT	Serine Threonine protein kinase	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HKD2_k127_321306_2	222534.KB893672_gene3005	2.019e-30	122.0	COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria,4EUWQ@85013|Frankiales	201174|Actinobacteria	IQ	AMP-binding enzyme C-terminal domain	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
HKD2_k127_326517_9	1192034.CAP_5633	5.106e-60	218.0	COG4402@1|root,COG4402@2|Bacteria	2|Bacteria	S	Uncharacterized protein conserved in bacteria (DUF2330)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2330
HKD2_k127_326517_8	448385.sce5113	2.063e-64	242.0	COG4402@1|root,COG4402@2|Bacteria	2|Bacteria	S	Uncharacterized protein conserved in bacteria (DUF2330)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2330
HKD2_k127_326517_7	448385.sce5113	8.475e-68	250.0	COG4402@1|root,COG4402@2|Bacteria	2|Bacteria	S	Uncharacterized protein conserved in bacteria (DUF2330)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2330
HKD2_k127_326517_10	1192034.CAP_0180	1.219e-58	222.0	COG0457@1|root,COG2956@1|root,COG3071@1|root,COG5373@1|root,COG0457@2|Bacteria,COG2956@2|Bacteria,COG3071@2|Bacteria,COG5373@2|Bacteria,1MVIW@1224|Proteobacteria,437VP@68525|delta/epsilon subdivisions,2WWNT@28221|Deltaproteobacteria,2YUC4@29|Myxococcales	28221|Deltaproteobacteria	G	repeat protein	agmK	-	-	-	-	-	-	-	-	-	-	-	TPR_19,TPR_6,TPR_7,TPR_8
HKD2_k127_326517_4	1192034.CAP_4285	4.011e-100	331.0	COG0745@1|root,COG0745@2|Bacteria,1MY2Z@1224|Proteobacteria,42MP1@68525|delta/epsilon subdivisions,2WJPD@28221|Deltaproteobacteria,2YURD@29|Myxococcales	28221|Deltaproteobacteria	K	Two component transcriptional regulator, winged helix family	phoB	-	-	ko:K07657	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
HKD2_k127_326517_6	1192034.CAP_5076	3.643e-76	273.0	COG0515@1|root,COG0515@2|Bacteria	1192034.CAP_5076|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_326517_2	1192034.CAP_1498	7.48e-140	464.0	COG0823@1|root,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	-	-	-	-	-	-	-	-	-	-	DUF4214,HYR,PD40,PKD,REJ
HKD2_k127_326517_17	448385.sce0848	7.033e-29	135.0	COG0515@1|root,COG0515@2|Bacteria	448385.sce0848|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_326517_18	391625.PPSIR1_16150	5.278e-12	79.0	2ANE2@1|root,31DCP@2|Bacteria,1QAIW@1224|Proteobacteria,43E1I@68525|delta/epsilon subdivisions,2WZFD@28221|Deltaproteobacteria,2Z20M@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_326517_14	1242864.D187_002593	7.401e-35	148.0	28RZD@1|root,2ZEBA@2|Bacteria,1RBEH@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_326517_5	1192034.CAP_4553	1.383e-90	308.0	COG1638@1|root,COG1638@2|Bacteria,1PJFW@1224|Proteobacteria,42PXK@68525|delta/epsilon subdivisions,2WJFU@28221|Deltaproteobacteria,2Z1WI@29|Myxococcales	28221|Deltaproteobacteria	G	Bacterial extracellular solute-binding protein, family 7	-	-	-	-	-	-	-	-	-	-	-	-	DctP
HKD2_k127_326517_3	1254432.SCE1572_25175	1.894e-127	417.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,42NB6@68525|delta/epsilon subdivisions,2WIWE@28221|Deltaproteobacteria,2YZKE@29|Myxococcales	28221|Deltaproteobacteria	O	Domain present in PSD-95, Dlg, and ZO-1/2.	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
HKD2_k127_326517_15	136993.KB900627_gene496	2.86e-31	130.0	COG1146@1|root,COG1146@2|Bacteria,1NCXI@1224|Proteobacteria,2UBEP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_6,Fer4_7
HKD2_k127_326517_1	1254432.SCE1572_43690	5.346e-161	547.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,42M0D@68525|delta/epsilon subdivisions,2WK8T@28221|Deltaproteobacteria,2YUE9@29|Myxococcales	28221|Deltaproteobacteria	I	Belongs to the thiolase family	-	-	2.3.1.16	ko:K00632	ko00071,ko00280,ko00281,ko00362,ko00592,ko00642,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00362,map00592,map00642,map01100,map01110,map01120,map01130,map01212	M00087,M00113	R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000	-	-	-	Thiolase_C,Thiolase_N
HKD2_k127_326517_0	1254432.SCE1572_43695	7.269e-190	599.0	COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,42MI5@68525|delta/epsilon subdivisions,2WITQ@28221|Deltaproteobacteria,2YU2Y@29|Myxococcales	28221|Deltaproteobacteria	I	3-hydroxyacyl-CoA dehydrogenase	-	-	1.1.1.35	ko:K07516	ko00071,ko00362,ko00650,ko01100,ko01120,ko01200,ko01212,map00071,map00362,map00650,map01100,map01120,map01200,map01212	M00087	R01975,R04737,R04739,R04741,R04743,R04745,R04748,R05305	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000	-	-	-	3HCDH,3HCDH_N,ECH_1,ECH_2
HKD2_k127_328154_0	290397.Adeh_2533	1.379e-171	546.0	COG0173@1|root,COG0173@2|Bacteria,1MUXB@1224|Proteobacteria,42NC6@68525|delta/epsilon subdivisions,2WJEV@28221|Deltaproteobacteria,2YTWY@29|Myxococcales	28221|Deltaproteobacteria	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
HKD2_k127_3294574_2	1394178.AWOO02000023_gene5542	7.405e-22	110.0	COG3247@1|root,COG3247@2|Bacteria,2I119@201174|Actinobacteria,4EJMN@85012|Streptosporangiales	201174|Actinobacteria	S	Short repeat of unknown function (DUF308)	-	-	-	-	-	-	-	-	-	-	-	-	DUF308
HKD2_k127_3294574_1	448385.sce8529	7.613e-51	191.0	COG1051@1|root,COG1051@2|Bacteria,1QUNH@1224|Proteobacteria,43C4F@68525|delta/epsilon subdivisions,2WS06@28221|Deltaproteobacteria,2Z2IP@29|Myxococcales	28221|Deltaproteobacteria	F	Belongs to the Nudix hydrolase family	-	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX
HKD2_k127_3294574_0	1254432.SCE1572_51515	5.26e-94	319.0	COG1413@1|root,COG1413@2|Bacteria	2|Bacteria	C	deoxyhypusine monooxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,HEAT_PBS,NB-ARC,cNMP_binding
HKD2_k127_3296221_12	1185652.USDA257_c38580	4.038e-05	57.0	COG3213@1|root,COG3213@2|Bacteria,1MUJK@1224|Proteobacteria,2TSQ2@28211|Alphaproteobacteria,4B9FM@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	NnrS protein	nnrS	-	-	ko:K07234	-	-	-	-	ko00000	-	-	-	NnrS
HKD2_k127_3296221_11	656024.FsymDg_2688	1.71e-06	59.0	COG2197@1|root,COG2197@2|Bacteria	2|Bacteria	K	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	GerE
HKD2_k127_3296221_1	375286.mma_0514	1.497e-102	362.0	COG3748@1|root,COG3748@2|Bacteria,1MWHB@1224|Proteobacteria,2VIC0@28216|Betaproteobacteria,473XM@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Urate oxidase N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	Urate_ox_N
HKD2_k127_3296221_10	616991.JPOO01000003_gene984	5.457e-07	61.0	COG5485@1|root,COG5485@2|Bacteria,4PNKP@976|Bacteroidetes,1IK8M@117743|Flavobacteriia	976|Bacteroidetes	S	SnoaL-like polyketide cyclase	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL
HKD2_k127_3296221_5	420662.Mpe_A0106	2.596e-39	166.0	COG2304@1|root,COG2304@2|Bacteria,1N2UU@1224|Proteobacteria	1224|Proteobacteria	S	Von willebrand factor, type a	-	-	-	-	-	-	-	-	-	-	-	-	VWA
HKD2_k127_3296221_9	448385.sce5811	2.215e-07	64.0	COG2304@1|root,COG2304@2|Bacteria	2|Bacteria	IU	oxidoreductase activity	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VWA
HKD2_k127_3296221_2	216594.MMAR_2965	1.093e-92	340.0	COG1056@1|root,COG3172@1|root,COG1056@2|Bacteria,COG3172@2|Bacteria,2GXG6@201174|Actinobacteria,238EN@1762|Mycobacteriaceae	201174|Actinobacteria	H	AAA domain	nadR	-	-	-	-	-	-	-	-	-	-	-	AAA_28
HKD2_k127_3296221_3	1122182.KB903836_gene4767	7.47e-89	325.0	COG1020@1|root,COG1020@2|Bacteria,2GISR@201174|Actinobacteria,4D8GT@85008|Micromonosporales	201174|Actinobacteria	Q	Non-ribosomal peptide synthetase modules and related proteins	-	-	-	ko:K04780	ko01053,map01053	-	-	-	ko00000,ko00001,ko01008	-	-	-	AMP-binding,AMP-binding_C,Condensation,NAD_binding_4,PP-binding,Thioesterase
HKD2_k127_3296221_6	1121015.N789_11245	3.512e-26	119.0	28IYZ@1|root,2Z8WJ@2|Bacteria,1N1QE@1224|Proteobacteria,1SQ03@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3296221_0	1267535.KB906767_gene491	5.819e-135	456.0	COG0367@1|root,COG0367@2|Bacteria,3Y6CC@57723|Acidobacteria	57723|Acidobacteria	E	TIGRFAM asparagine synthase (glutamine-hydrolyzing)	-	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
HKD2_k127_3296221_4	402777.KB235903_gene1488	1.205e-48	184.0	COG1063@1|root,COG1063@2|Bacteria,1FZZE@1117|Cyanobacteria,1H7Y9@1150|Oscillatoriales	2|Bacteria	E	COG1063 Threonine dehydrogenase and related Zn-dependent	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
HKD2_k127_3301142_0	378806.STAUR_4782	1.301e-63	222.0	COG0010@1|root,COG0010@2|Bacteria,1RCQX@1224|Proteobacteria,42R4M@68525|delta/epsilon subdivisions,2X5RQ@28221|Deltaproteobacteria,2YYRW@29|Myxococcales	28221|Deltaproteobacteria	E	Belongs to the arginase family	speB	-	3.5.3.11	ko:K01480	ko00330,ko01100,map00330,map01100	M00133	R01157	RC00024,RC00329	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
HKD2_k127_3301142_2	269800.Tfu_3065	4.957e-42	179.0	COG0515@1|root,COG3468@1|root,COG0515@2|Bacteria,COG3468@2|Bacteria,2GMPZ@201174|Actinobacteria,4EHZK@85012|Streptosporangiales	201174|Actinobacteria	KLT	Protein tyrosine kinase	pknA	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
HKD2_k127_3301142_1	1192034.CAP_1663	1.021e-49	179.0	COG0173@1|root,COG0173@2|Bacteria,1MUXB@1224|Proteobacteria,42NC6@68525|delta/epsilon subdivisions,2WJEV@28221|Deltaproteobacteria,2YTWY@29|Myxococcales	28221|Deltaproteobacteria	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
HKD2_k127_331280_3	1265505.ATUG01000002_gene2637	1.899e-66	230.0	29CZA@1|root,2ZZXB@2|Bacteria,1RFNE@1224|Proteobacteria,42TRV@68525|delta/epsilon subdivisions,2WR3X@28221|Deltaproteobacteria,2MKTT@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_331280_0	1254432.SCE1572_00335	7.937e-93	321.0	COG0515@1|root,COG0515@2|Bacteria	1254432.SCE1572_00335|-	KLT	protein kinase activity	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	-
HKD2_k127_331280_1	1192034.CAP_6502	2.208e-83	292.0	COG1470@1|root,COG1470@2|Bacteria,1Q9IM@1224|Proteobacteria,434EQ@68525|delta/epsilon subdivisions,2WYS3@28221|Deltaproteobacteria,2Z0GH@29|Myxococcales	28221|Deltaproteobacteria	S	PEGA domain	-	-	-	-	-	-	-	-	-	-	-	-	PEGA
HKD2_k127_331280_2	448385.sce4951	7.076e-74	278.0	2ANDU@1|root,31DCF@2|Bacteria,1QAIC@1224|Proteobacteria,43541@68525|delta/epsilon subdivisions,2X956@28221|Deltaproteobacteria,2Z1ZX@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	VCBS
HKD2_k127_331280_7	483219.LILAB_13630	3.474e-11	76.0	COG3391@1|root,COG3391@2|Bacteria,1QX9W@1224|Proteobacteria,43C32@68525|delta/epsilon subdivisions,2X7DQ@28221|Deltaproteobacteria,2YVS2@29|Myxococcales	28221|Deltaproteobacteria	S	Stigma-specific protein, Stig1	-	-	-	-	-	-	-	-	-	-	-	-	Stig1
HKD2_k127_3320632_15	234267.Acid_5283	3.059e-06	53.0	COG0436@1|root,COG0436@2|Bacteria,3Y2VQ@57723|Acidobacteria	57723|Acidobacteria	E	PFAM Aminotransferase class I and II	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
HKD2_k127_3320632_14	1384054.N790_10235	2.451e-06	60.0	COG3040@1|root,COG3040@2|Bacteria,1NDMN@1224|Proteobacteria,1SBUP@1236|Gammaproteobacteria,1XB5A@135614|Xanthomonadales	135614|Xanthomonadales	M	lipid binding	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3320632_3	1192034.CAP_4553	8.205e-89	304.0	COG1638@1|root,COG1638@2|Bacteria,1PJFW@1224|Proteobacteria,42PXK@68525|delta/epsilon subdivisions,2WJFU@28221|Deltaproteobacteria,2Z1WI@29|Myxococcales	28221|Deltaproteobacteria	G	Bacterial extracellular solute-binding protein, family 7	-	-	-	-	-	-	-	-	-	-	-	-	DctP
HKD2_k127_3320632_4	1192034.CAP_3361	2.939e-76	265.0	COG5660@1|root,2Z7TM@2|Bacteria,1PMCV@1224|Proteobacteria,42Q81@68525|delta/epsilon subdivisions,2WIJ3@28221|Deltaproteobacteria,2Z2J1@29|Myxococcales	28221|Deltaproteobacteria	S	TRAP transporter T-component	-	-	-	-	-	-	-	-	-	-	-	-	TAtT
HKD2_k127_3320632_11	1192034.CAP_3048	4.954e-41	158.0	COG1191@1|root,COG1191@2|Bacteria,1MWEU@1224|Proteobacteria,42QQ8@68525|delta/epsilon subdivisions,2WMX3@28221|Deltaproteobacteria,2YVY0@29|Myxococcales	28221|Deltaproteobacteria	K	Sigma-70, region 4	fliA	-	-	ko:K02405	ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111	-	-	-	ko00000,ko00001,ko02035,ko03021	-	-	-	Sigma70_r2,Sigma70_r3,Sigma70_r4
HKD2_k127_3320632_7	1254432.SCE1572_37285	8.768e-58	214.0	COG1388@1|root,COG3108@1|root,COG1388@2|Bacteria,COG3108@2|Bacteria,1QABK@1224|Proteobacteria,434YH@68525|delta/epsilon subdivisions,2WZ9D@28221|Deltaproteobacteria,2Z1MT@29|Myxococcales	28221|Deltaproteobacteria	M	Bacterial protein of unknown function (DUF882)	-	-	-	-	-	-	-	-	-	-	-	-	LysM,Peptidase_M15_2
HKD2_k127_3320632_2	1192034.CAP_3050	4.361e-128	442.0	COG4972@1|root,COG4972@2|Bacteria,1MX8P@1224|Proteobacteria,42M36@68525|delta/epsilon subdivisions,2WJFJ@28221|Deltaproteobacteria,2YUJQ@29|Myxococcales	28221|Deltaproteobacteria	NU	pilus assembly protein	pilM	-	-	ko:K02662	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilM_2
HKD2_k127_3320632_8	448385.sce6187	1.887e-48	199.0	COG3166@1|root,COG3166@2|Bacteria,1Q1I0@1224|Proteobacteria,42W65@68525|delta/epsilon subdivisions,2WS79@28221|Deltaproteobacteria,2Z2I6@29|Myxococcales	28221|Deltaproteobacteria	NU	Fimbrial assembly protein (PilN)	pilN	-	-	ko:K02663	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilN
HKD2_k127_3320632_12	1192034.CAP_3052	7.446e-41	161.0	COG3167@1|root,COG3167@2|Bacteria,1RBGW@1224|Proteobacteria,42S1V@68525|delta/epsilon subdivisions,2WNDR@28221|Deltaproteobacteria,2YVZQ@29|Myxococcales	28221|Deltaproteobacteria	NU	Pilus assembly protein, PilO	pilO	-	-	ko:K02664	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilO
HKD2_k127_3320632_10	1254432.SCE1572_37265	3.335e-41	161.0	COG3168@1|root,COG3168@2|Bacteria	2|Bacteria	NU	Pilus assembly protein, PilP	pilP	-	-	ko:K02665	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilP
HKD2_k127_3320632_0	448385.sce6184	2.758e-268	848.0	COG4796@1|root,COG4796@2|Bacteria,1QTT6@1224|Proteobacteria,42MKN@68525|delta/epsilon subdivisions,2WJV6@28221|Deltaproteobacteria,2YTV4@29|Myxococcales	28221|Deltaproteobacteria	U	type IV pilus secretin PilQ	pilQ	-	-	ko:K02666	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	AMIN,STN,Secretin,Secretin_N
HKD2_k127_3320632_1	1192034.CAP_5909	2.469e-169	550.0	COG3291@1|root,COG3291@2|Bacteria,1QEIS@1224|Proteobacteria,4389M@68525|delta/epsilon subdivisions,2X3J1@28221|Deltaproteobacteria,2YWAB@29|Myxococcales	28221|Deltaproteobacteria	S	IgGFc binding protein	-	-	-	-	-	-	-	-	-	-	-	-	IgGFc_binding
HKD2_k127_3320632_13	1173263.Syn7502_03095	4.868e-30	126.0	COG3428@1|root,COG3428@2|Bacteria,1GE7A@1117|Cyanobacteria	1117|Cyanobacteria	S	Bacterial PH domain	-	-	-	-	-	-	-	-	-	-	-	-	bPH_2
HKD2_k127_3320632_6	877455.Metbo_0048	2.579e-72	259.0	COG0477@1|root,arCOG02682@2157|Archaea,2XWP6@28890|Euryarchaeota,23PB6@183925|Methanobacteria	183925|Methanobacteria	G	Sugar (and other) transporter	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3322725_1	1192034.CAP_7365	4.823e-65	232.0	COG0144@1|root,COG0781@1|root,COG0144@2|Bacteria,COG0781@2|Bacteria,1MWPE@1224|Proteobacteria,42P2T@68525|delta/epsilon subdivisions,2WJ9B@28221|Deltaproteobacteria,2YV48@29|Myxococcales	28221|Deltaproteobacteria	J	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA	rsmB	-	2.1.1.176	ko:K03500	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltr_RsmB-F,Methyltr_RsmF_N,NusB
HKD2_k127_3322725_0	1254432.SCE1572_39080	5.163e-165	529.0	COG0508@1|root,COG0508@2|Bacteria,1MUJD@1224|Proteobacteria,42N18@68525|delta/epsilon subdivisions,2X5JH@28221|Deltaproteobacteria,2YZ22@29|Myxococcales	28221|Deltaproteobacteria	C	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex	-	-	2.3.1.61	ko:K00658	ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R02570,R02571,R08549	RC00004,RC02727,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
HKD2_k127_3322725_5	383372.Rcas_1535	2.694e-12	79.0	COG0500@1|root,COG2226@2|Bacteria,2G948@200795|Chloroflexi,376TJ@32061|Chloroflexia	32061|Chloroflexia	Q	Methyltransferase type 12	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
HKD2_k127_3322725_3	1123073.KB899244_gene438	3.695e-27	128.0	COG4320@1|root,COG4320@2|Bacteria,1N6EW@1224|Proteobacteria,1S7YN@1236|Gammaproteobacteria,1X8KV@135614|Xanthomonadales	135614|Xanthomonadales	S	Uncharacterized protein conserved in bacteria (DUF2252)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2252
HKD2_k127_3322725_4	765910.MARPU_04070	1.571e-14	87.0	COG1663@1|root,COG1663@2|Bacteria,1MU8G@1224|Proteobacteria,1RMMW@1236|Gammaproteobacteria,1WWWV@135613|Chromatiales	135613|Chromatiales	M	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)	lpxK	-	2.7.1.130	ko:K00912	ko00540,ko01100,map00540,map01100	M00060	R04657	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	LpxK
HKD2_k127_3322725_2	448385.sce8626	5.654e-47	171.0	COG1716@1|root,COG2199@1|root,COG1716@2|Bacteria,COG3706@2|Bacteria,1MZV7@1224|Proteobacteria,43BQ2@68525|delta/epsilon subdivisions,2WQ6X@28221|Deltaproteobacteria,2YWRT@29|Myxococcales	28221|Deltaproteobacteria	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	FHA,GGDEF,Yop-YscD_cpl
HKD2_k127_3373960_1	861299.J421_6017	2.146e-33	132.0	COG0262@1|root,COG0262@2|Bacteria	2|Bacteria	H	dihydrofolate reductase activity	FolA	-	-	-	-	-	-	-	-	-	-	-	RibD_C
HKD2_k127_3373960_3	1443665.JACA01000003_gene901	6.692e-24	113.0	2CASV@1|root,33NEK@2|Bacteria,4PPZ9@976|Bacteroidetes,1IKXN@117743|Flavobacteriia,2YJ4P@290174|Aquimarina	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3373960_2	1192034.CAP_0043	2.321e-30	134.0	COG4323@1|root,COG4323@2|Bacteria,1N16T@1224|Proteobacteria,4315K@68525|delta/epsilon subdivisions,2WWYY@28221|Deltaproteobacteria,2YVYB@29|Myxococcales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF962)	-	-	-	-	-	-	-	-	-	-	-	-	DUF962
HKD2_k127_3393812_4	1089553.Tph_c04460	1.208e-09	68.0	COG1846@1|root,COG1846@2|Bacteria,1V9AQ@1239|Firmicutes,24GW2@186801|Clostridia	186801|Clostridia	K	MarR family	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
HKD2_k127_3393812_0	448385.sce7902	3.016e-240	789.0	COG2304@1|root,COG3712@1|root,COG2304@2|Bacteria,COG3712@2|Bacteria,1QRQ1@1224|Proteobacteria,4341K@68525|delta/epsilon subdivisions,2X4NI@28221|Deltaproteobacteria,2YZAV@29|Myxococcales	28221|Deltaproteobacteria	PT	Vault protein inter-alpha-trypsin domain	-	-	-	-	-	-	-	-	-	-	-	-	FecR,VIT,VWA_3
HKD2_k127_3393812_2	1254432.SCE1572_26330	1.146e-31	126.0	COG2442@1|root,COG2442@2|Bacteria	2|Bacteria	K	InterPro IPR007367	-	-	-	-	-	-	-	-	-	-	-	-	DUF433
HKD2_k127_3393812_3	323848.Nmul_A1488	7.081e-11	71.0	COG3729@1|root,COG3729@2|Bacteria,1NH1J@1224|Proteobacteria,2VY5U@28216|Betaproteobacteria,373KS@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Stress-induced bacterial acidophilic repeat motif	-	-	-	ko:K06884	-	-	-	-	ko00000	-	-	-	KGG
HKD2_k127_3393812_1	497964.CfE428DRAFT_3605	2.711e-38	148.0	COG0364@1|root,COG0364@2|Bacteria,46SHX@74201|Verrucomicrobia	74201|Verrucomicrobia	G	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone	zwf	-	1.1.1.363,1.1.1.49	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	M00004,M00006,M00008	R00835,R02736,R10907	RC00001,RC00066	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	G6PD_C,G6PD_N
HKD2_k127_3402542_4	1254432.SCE1572_41390	3.367e-74	258.0	COG0639@1|root,COG0639@2|Bacteria,1RD8M@1224|Proteobacteria,42RQP@68525|delta/epsilon subdivisions,2WNQ7@28221|Deltaproteobacteria,2YVU0@29|Myxococcales	28221|Deltaproteobacteria	T	Diadenosine tetraphosphatase and related serine threonine protein phosphatases	-	-	3.1.3.16	ko:K07313	-	-	-	-	ko00000,ko01000	-	-	-	Metallophos,Metallophos_2
HKD2_k127_3402542_9	744979.R2A130_2076	1.174e-24	118.0	COG2911@1|root,COG2931@1|root,COG4932@1|root,COG5295@1|root,COG2911@2|Bacteria,COG2931@2|Bacteria,COG4932@2|Bacteria,COG5295@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	COG2931 RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin,HCBP_related,He_PIG,HemolysinCabind
HKD2_k127_3402542_0	1254432.SCE1572_41395	1.535e-197	625.0	COG0448@1|root,COG0448@2|Bacteria,1MVTC@1224|Proteobacteria,42NGK@68525|delta/epsilon subdivisions,2WM29@28221|Deltaproteobacteria,2YU1M@29|Myxococcales	28221|Deltaproteobacteria	H	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans	glgC	-	2.7.7.27	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	M00565	R00948	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2768	NTP_transferase
HKD2_k127_3402542_6	1192034.CAP_0071	5.752e-65	234.0	COG1975@1|root,COG1975@2|Bacteria,1R3RT@1224|Proteobacteria,43BHQ@68525|delta/epsilon subdivisions,2X6W7@28221|Deltaproteobacteria,2YVKW@29|Myxococcales	28221|Deltaproteobacteria	O	XdhC Rossmann domain	pcmU	-	-	ko:K07402	-	-	-	-	ko00000	-	-	-	XdhC_C,XdhC_CoxI
HKD2_k127_3402542_3	448385.sce3908	2.918e-85	292.0	COG4798@1|root,COG4798@2|Bacteria,1NNHX@1224|Proteobacteria,437RC@68525|delta/epsilon subdivisions,2X304@28221|Deltaproteobacteria,2YTVQ@29|Myxococcales	28221|Deltaproteobacteria	S	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PCMT
HKD2_k127_3402542_2	1384056.N787_03590	5.771e-127	421.0	COG1502@1|root,COG1502@2|Bacteria,1MWUW@1224|Proteobacteria,1RPQG@1236|Gammaproteobacteria,1X48D@135614|Xanthomonadales	135614|Xanthomonadales	I	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol	cls	-	-	ko:K06131	ko00564,ko01100,map00564,map01100	-	R07390	RC00017	ko00000,ko00001,ko01000	-	-	-	PLDc_2,PLDc_N
HKD2_k127_3402542_5	1254432.SCE1572_03695	2.642e-73	265.0	COG0515@1|root,COG2319@1|root,COG0515@2|Bacteria,COG2319@2|Bacteria	2|Bacteria	S	anaphase-promoting complex binding	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,WD40,YukD
HKD2_k127_3402542_7	448385.sce5502	1.404e-63	237.0	COG0515@1|root,COG1262@1|root,COG0515@2|Bacteria,COG1262@2|Bacteria,1MZ25@1224|Proteobacteria,42PUT@68525|delta/epsilon subdivisions,2WKN0@28221|Deltaproteobacteria,2YVT8@29|Myxococcales	28221|Deltaproteobacteria	KLT	Sulfatase-modifying factor enzyme 1	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	FGE-sulfatase,Pkinase
HKD2_k127_3402542_10	448385.sce7630	2.537e-15	82.0	COG1555@1|root,COG1555@2|Bacteria,1Q1BE@1224|Proteobacteria,43764@68525|delta/epsilon subdivisions,2X24M@28221|Deltaproteobacteria,2Z2UP@29|Myxococcales	28221|Deltaproteobacteria	L	Helix-hairpin-helix motif	-	-	-	ko:K02237	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	HHH_3
HKD2_k127_3402542_8	1254432.SCE1572_51670	7.79e-61	234.0	COG0040@1|root,COG0040@2|Bacteria,1MUCY@1224|Proteobacteria,42N9N@68525|delta/epsilon subdivisions,2WNAZ@28221|Deltaproteobacteria,2Z2YU@29|Myxococcales	28221|Deltaproteobacteria	F	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity	hisG	GO:0000105,GO:0003674,GO:0003824,GO:0003879,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.4.2.17	ko:K00765	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002,ko01000	-	-	-	HisG
HKD2_k127_3402542_1	1254432.SCE1572_51675	2.861e-193	611.0	COG0766@1|root,COG0766@2|Bacteria,1MUH7@1224|Proteobacteria,42MJT@68525|delta/epsilon subdivisions,2WJ7W@28221|Deltaproteobacteria,2YUNU@29|Myxococcales	28221|Deltaproteobacteria	M	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine	murA	-	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase
HKD2_k127_3416081_4	1192034.CAP_1526	3.795e-103	348.0	COG0104@1|root,COG0104@2|Bacteria,1MU5B@1224|Proteobacteria,42M9E@68525|delta/epsilon subdivisions,2WJ3F@28221|Deltaproteobacteria,2YUGA@29|Myxococcales	28221|Deltaproteobacteria	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
HKD2_k127_3416081_6	1254432.SCE1572_50815	7.589e-84	303.0	COG3705@1|root,COG3705@2|Bacteria,1MWIG@1224|Proteobacteria,43CGP@68525|delta/epsilon subdivisions,2X7RU@28221|Deltaproteobacteria,2YV1F@29|Myxococcales	28221|Deltaproteobacteria	E	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine	hisZ	-	-	ko:K02502	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002	-	-	-	tRNA-synt_His
HKD2_k127_3416081_7	1254432.SCE1572_50820	2.878e-54	196.0	COG1595@1|root,COG1595@2|Bacteria,1PD3E@1224|Proteobacteria,43E55@68525|delta/epsilon subdivisions,2X98H@28221|Deltaproteobacteria,2Z2M0@29|Myxococcales	28221|Deltaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD2_k127_3416081_1	448385.sce7789	1.14e-179	587.0	COG3119@1|root,COG3119@2|Bacteria,1QZHU@1224|Proteobacteria,42PUM@68525|delta/epsilon subdivisions,2X7T5@28221|Deltaproteobacteria,2Z00V@29|Myxococcales	28221|Deltaproteobacteria	P	Sulfatase	-	-	3.1.6.6	ko:K01133	-	-	-	-	ko00000,ko01000	-	-	-	Cu-binding_MopE,Sulfatase
HKD2_k127_3416081_5	1192034.CAP_2080	1.519e-99	341.0	COG4974@1|root,COG4974@2|Bacteria,1QU6A@1224|Proteobacteria,42Q4U@68525|delta/epsilon subdivisions,2WJ08@28221|Deltaproteobacteria,2YV00@29|Myxococcales	28221|Deltaproteobacteria	D	Belongs to the 'phage' integrase family. XerC subfamily	xerC	-	-	ko:K03733,ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
HKD2_k127_3416081_11	1121405.dsmv_0101	1.935e-07	65.0	COG3216@1|root,COG3216@2|Bacteria,1QEG2@1224|Proteobacteria,42VUY@68525|delta/epsilon subdivisions,2WRD1@28221|Deltaproteobacteria,2MM28@213118|Desulfobacterales	28221|Deltaproteobacteria	S	protein conserved in bacteria (DUF2062)	-	-	-	ko:K09928	-	-	-	-	ko00000	-	-	-	DUF2062
HKD2_k127_3416081_2	1192034.CAP_7037	4.697e-145	473.0	COG0006@1|root,COG0006@2|Bacteria,1MUZS@1224|Proteobacteria,42M1K@68525|delta/epsilon subdivisions,2WJRH@28221|Deltaproteobacteria,2YUPB@29|Myxococcales	28221|Deltaproteobacteria	E	Aminopeptidase P, N-terminal domain	pepP	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	AMP_N,Peptidase_M24
HKD2_k127_3416081_8	448385.sce5954	1.446e-20	97.0	2AQ5Z@1|root,31FBG@2|Bacteria,1PCFM@1224|Proteobacteria,43E4N@68525|delta/epsilon subdivisions,2X980@28221|Deltaproteobacteria,2Z2HX@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3416081_9	485913.Krac_4700	6.716e-15	87.0	2DRZ7@1|root,33DSV@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3416081_0	1254432.SCE1572_15260	9.155e-188	610.0	COG0564@1|root,COG2265@1|root,COG0564@2|Bacteria,COG2265@2|Bacteria,1MV3A@1224|Proteobacteria,42ME9@68525|delta/epsilon subdivisions,2WKF0@28221|Deltaproteobacteria,2Z219@29|Myxococcales	28221|Deltaproteobacteria	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family	rumA	-	2.1.1.190	ko:K03215	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TRAM,tRNA_U5-meth_tr
HKD2_k127_3416081_3	1254432.SCE1572_05990	5.031e-122	411.0	COG3320@1|root,COG3320@2|Bacteria,1QSHC@1224|Proteobacteria,42W94@68525|delta/epsilon subdivisions,2WR9E@28221|Deltaproteobacteria,2YUNG@29|Myxococcales	28221|Deltaproteobacteria	Q	Male sterility protein	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_4
HKD2_k127_3442726_3	1254432.SCE1572_39470	6.705e-09	57.0	COG1656@1|root,COG1656@2|Bacteria,1R442@1224|Proteobacteria,42RIS@68525|delta/epsilon subdivisions,2WMWC@28221|Deltaproteobacteria,2Z1X2@29|Myxococcales	28221|Deltaproteobacteria	S	Mut7-C RNAse domain	-	-	-	ko:K09122	-	-	-	-	ko00000	-	-	-	Mut7-C,Ub-Mut7C
HKD2_k127_3442726_0	1192034.CAP_4442	6.802e-110	373.0	COG0515@1|root,COG0515@2|Bacteria	1192034.CAP_4442|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3442726_2	1192034.CAP_7398	1.572e-25	106.0	COG0323@1|root,COG0323@2|Bacteria,1MV61@1224|Proteobacteria,42MFX@68525|delta/epsilon subdivisions,2WJ91@28221|Deltaproteobacteria,2YU35@29|Myxococcales	28221|Deltaproteobacteria	L	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex	mutL	GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391	-	ko:K03572	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	DNA_mis_repair,HATPase_c_3,MutL_C
HKD2_k127_3443405_4	448385.sce6189	7.976e-06	48.0	COG1388@1|root,COG3108@1|root,COG1388@2|Bacteria,COG3108@2|Bacteria,1QABK@1224|Proteobacteria,434YH@68525|delta/epsilon subdivisions,2WZ9D@28221|Deltaproteobacteria,2Z1MT@29|Myxococcales	28221|Deltaproteobacteria	M	Bacterial protein of unknown function (DUF882)	-	-	-	-	-	-	-	-	-	-	-	-	LysM,Peptidase_M15_2
HKD2_k127_3443405_0	1254432.SCE1572_26715	1.494e-114	377.0	COG3239@1|root,COG3239@2|Bacteria,1R8YH@1224|Proteobacteria,4384P@68525|delta/epsilon subdivisions,2X3ER@28221|Deltaproteobacteria,2YVR4@29|Myxococcales	28221|Deltaproteobacteria	I	fatty acid desaturase	-	-	-	-	-	-	-	-	-	-	-	-	FA_desaturase
HKD2_k127_3443405_3	391625.PPSIR1_02276	3.588e-18	85.0	COG3239@1|root,COG3239@2|Bacteria,1R8YH@1224|Proteobacteria,4384P@68525|delta/epsilon subdivisions,2X3ER@28221|Deltaproteobacteria,2YVR4@29|Myxococcales	28221|Deltaproteobacteria	I	fatty acid desaturase	-	-	-	-	-	-	-	-	-	-	-	-	FA_desaturase
HKD2_k127_3443988_0	483219.LILAB_18975	9.115e-57	222.0	COG0515@1|root,COG0515@2|Bacteria	483219.LILAB_18975|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3446054_1	1146883.BLASA_1208	4.499e-61	225.0	COG2197@1|root,COG2197@2|Bacteria,2GPKD@201174|Actinobacteria	201174|Actinobacteria	K	luxR family	-	-	-	-	-	-	-	-	-	-	-	-	GerE
HKD2_k127_3446054_4	1278073.MYSTI_05918	7.759e-50	187.0	COG0596@1|root,COG0596@2|Bacteria,1RFKC@1224|Proteobacteria,439ND@68525|delta/epsilon subdivisions,2X4ZP@28221|Deltaproteobacteria,2YZWF@29|Myxococcales	28221|Deltaproteobacteria	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
HKD2_k127_3446054_0	448385.sce4512	1.072e-71	256.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,42MVV@68525|delta/epsilon subdivisions,2X4JB@28221|Deltaproteobacteria,2YZ4I@29|Myxococcales	28221|Deltaproteobacteria	KLT	Family membership	-	-	2.7.11.1	ko:K08884	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HKD2_k127_3446054_3	1242864.D187_000090	4.526e-54	202.0	COG2193@1|root,COG2193@2|Bacteria,1RCW7@1224|Proteobacteria,42SK2@68525|delta/epsilon subdivisions,2WPB3@28221|Deltaproteobacteria,2Z0CU@29|Myxococcales	28221|Deltaproteobacteria	P	Iron-storage protein, whose ferroxidase center binds Fe(2 ) ions, oxidizes them by dioxygen to Fe(3 ), and participates in the subsequent Fe(3 ) oxide mineral core formation within the central cavity of the protein complex	bfr	GO:0006873,GO:0006875,GO:0006879,GO:0006880,GO:0008150,GO:0009987,GO:0019725,GO:0030003,GO:0042592,GO:0046916,GO:0048878,GO:0050801,GO:0051179,GO:0051235,GO:0051238,GO:0051641,GO:0051651,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0097577,GO:0098771	1.16.3.1	ko:K03594	ko00860,map00860	-	R00078	RC02758	ko00000,ko00001,ko01000	-	-	-	Ferritin
HKD2_k127_3446054_8	105420.BBPO01000029_gene6761	3.735e-10	64.0	COG2906@1|root,COG2906@2|Bacteria,2IQ4K@201174|Actinobacteria,2NJHY@228398|Streptacidiphilus	201174|Actinobacteria	P	BFD-like [2Fe-2S] binding domain	-	-	-	ko:K02192	-	-	-	-	ko00000	-	-	-	Fer2_BFD
HKD2_k127_3446054_9	1144275.COCOR_04466	0.0001301	52.0	COG3055@1|root,COG3055@2|Bacteria,1QAU8@1224|Proteobacteria,435AV@68525|delta/epsilon subdivisions,2WZN1@28221|Deltaproteobacteria,2Z2EF@29|Myxococcales	2|Bacteria	S	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses	-	-	-	-	-	-	-	-	-	-	-	-	Kelch_1
HKD2_k127_3446054_2	1128421.JAGA01000001_gene2255	1.361e-59	224.0	COG0515@1|root,COG0515@2|Bacteria	1128421.JAGA01000001_gene2255|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3446054_6	1537715.JQFJ01000002_gene1928	5.746e-25	110.0	COG0797@1|root,COG0797@2|Bacteria,1MZ8S@1224|Proteobacteria,2UBTC@28211|Alphaproteobacteria,2K697@204457|Sphingomonadales	204457|Sphingomonadales	M	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides	-	-	-	ko:K03642	-	-	-	-	ko00000	-	-	-	DPBB_1
HKD2_k127_3446054_5	1254432.SCE1572_12480	2.072e-25	106.0	COG0642@1|root,COG3850@1|root,COG2205@2|Bacteria,COG3850@2|Bacteria,1N9SU@1224|Proteobacteria,43BZY@68525|delta/epsilon subdivisions,2X39W@28221|Deltaproteobacteria,2YV13@29|Myxococcales	28221|Deltaproteobacteria	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
HKD2_k127_3479870_1	1278073.MYSTI_00081	3.683e-88	314.0	COG0784@1|root,COG4191@1|root,COG0784@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42PZ5@68525|delta/epsilon subdivisions,2WM5Q@28221|Deltaproteobacteria,2YX39@29|Myxococcales	28221|Deltaproteobacteria	T	PAS fold	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3,PAS_8,PAS_9,Response_reg
HKD2_k127_3479870_6	1123261.AXDW01000009_gene106	1.25e-22	113.0	COG0457@1|root,COG0457@2|Bacteria,1NFQW@1224|Proteobacteria,1RZRJ@1236|Gammaproteobacteria,1XA50@135614|Xanthomonadales	135614|Xanthomonadales	S	Tetratricopeptide TPR_2 repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	GT87
HKD2_k127_3479870_4	1396418.BATQ01000143_gene3479	8.079e-42	167.0	COG3239@1|root,COG3239@2|Bacteria,46SX7@74201|Verrucomicrobia	74201|Verrucomicrobia	I	Fatty acid desaturase	desA	-	1.14.19.23,1.14.19.45	ko:K10255	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000,ko01004	-	-	-	FA_desaturase
HKD2_k127_3479870_5	1283299.AUKG01000003_gene373	2.736e-29	122.0	COG1846@1|root,COG1846@2|Bacteria,2HRTE@201174|Actinobacteria,4CTWX@84995|Rubrobacteria	84995|Rubrobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3479870_0	1112216.JH594425_gene3158	2.933e-152	489.0	COG0673@1|root,COG0673@2|Bacteria,1MVT5@1224|Proteobacteria,2TV1T@28211|Alphaproteobacteria,2K8A7@204457|Sphingomonadales	204457|Sphingomonadales	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
HKD2_k127_3479870_2	1112216.JH594425_gene3157	6.349e-82	284.0	COG0673@1|root,COG0673@2|Bacteria,1MZIG@1224|Proteobacteria,2U9KC@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
HKD2_k127_3479870_3	1192034.CAP_5425	3.444e-76	265.0	COG4856@1|root,COG4856@2|Bacteria,1QARN@1224|Proteobacteria,4359B@68525|delta/epsilon subdivisions,2X973@28221|Deltaproteobacteria,2Z2BE@29|Myxococcales	28221|Deltaproteobacteria	S	YbbR-like protein	-	-	-	-	-	-	-	-	-	-	-	-	YbbR
HKD2_k127_3494212_1	1192034.CAP_5028	1.46e-159	539.0	COG0457@1|root,COG0457@2|Bacteria,1MXMD@1224|Proteobacteria,42NZK@68525|delta/epsilon subdivisions,2WIY5@28221|Deltaproteobacteria,2YVS5@29|Myxococcales	28221|Deltaproteobacteria	NU	zinc-ribbon domain	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_14,TPR_16,TPR_19,TPR_2,TPR_6,TPR_8,zinc_ribbon_4
HKD2_k127_3494212_8	1254432.SCE1572_27150	1.053e-63	246.0	COG0030@1|root,COG0030@2|Bacteria,1MVNU@1224|Proteobacteria,42QAC@68525|delta/epsilon subdivisions,2WN8H@28221|Deltaproteobacteria,2YVAS@29|Myxococcales	28221|Deltaproteobacteria	J	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
HKD2_k127_3494212_3	1254432.SCE1572_27145	2.399e-129	432.0	COG1721@1|root,COG1721@2|Bacteria,1QN1W@1224|Proteobacteria,434YE@68525|delta/epsilon subdivisions,2WZ9B@28221|Deltaproteobacteria,2Z1MQ@29|Myxococcales	28221|Deltaproteobacteria	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
HKD2_k127_3494212_2	1254432.SCE1572_27140	1.727e-141	469.0	COG0714@1|root,COG0714@2|Bacteria,1MUFN@1224|Proteobacteria,42NCX@68525|delta/epsilon subdivisions,2WJUZ@28221|Deltaproteobacteria,2YXCF@29|Myxococcales	28221|Deltaproteobacteria	S	MCM2/3/5 family	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
HKD2_k127_3494212_6	1254432.SCE1572_27135	1.187e-75	270.0	2AGZQ@1|root,3178G@2|Bacteria,1PYI9@1224|Proteobacteria,435DD@68525|delta/epsilon subdivisions,2WZQZ@28221|Deltaproteobacteria,2Z2JG@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3494212_7	448385.sce3127	1.24e-67	252.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3494212_11	512565.AMIS_35730	1.265e-06	61.0	COG3250@1|root,COG3250@2|Bacteria,2GMAT@201174|Actinobacteria	201174|Actinobacteria	G	Belongs to the glycosyl hydrolase 2 family	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N,Laminin_G_3,PA14
HKD2_k127_3494212_0	292459.STH1757	2.099e-195	639.0	COG0249@1|root,COG0249@2|Bacteria,1TPRJ@1239|Firmicutes,248GI@186801|Clostridia	186801|Clostridia	L	that it carries out the mismatch recognition step. This protein has a weak ATPase activity	mutS	-	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
HKD2_k127_3494212_9	246197.MXAN_4993	2.619e-20	103.0	COG0697@1|root,COG0697@2|Bacteria,1Q97J@1224|Proteobacteria,43417@68525|delta/epsilon subdivisions,2X4KS@28221|Deltaproteobacteria,2YZ7S@29|Myxococcales	28221|Deltaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HKD2_k127_3494212_4	1192034.CAP_4064	3.409e-128	428.0	COG3291@1|root,COG3291@2|Bacteria	2|Bacteria	S	metallopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	CBM60,CHU_C,Glyco_hydro_8,IgGFc_binding,PA14,PKD,PQQ,PQQ_2,fn3
HKD2_k127_3497566_4	448385.sce6248	9.886e-14	85.0	COG2854@1|root,COG2854@2|Bacteria,1NKFA@1224|Proteobacteria,42U8G@68525|delta/epsilon subdivisions,2WQPS@28221|Deltaproteobacteria,2YVV1@29|Myxococcales	28221|Deltaproteobacteria	Q	ABC-type transport system involved in resistance to organic solvents auxiliary component	-	-	-	ko:K07323	ko02010,map02010	M00210	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27.3	-	-	MlaC
HKD2_k127_3497566_2	1254432.SCE1572_37525	6.893e-110	370.0	COG3852@1|root,COG3852@2|Bacteria,1QVPN@1224|Proteobacteria,42PS3@68525|delta/epsilon subdivisions,2X7MQ@28221|Deltaproteobacteria,2YVCB@29|Myxococcales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	2.7.13.3	ko:K02668	ko02020,map02020	M00501	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	HATPase_c,HisKA,PAS,PAS_8
HKD2_k127_3497566_1	448385.sce6250	8.741e-159	517.0	COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,42NES@68525|delta/epsilon subdivisions,2WJ0V@28221|Deltaproteobacteria,2YU38@29|Myxococcales	28221|Deltaproteobacteria	NU	Type II secretion system (T2SS), protein F	pilC	-	-	ko:K02653	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSF
HKD2_k127_3497566_3	243230.DR_A0216	4.029e-30	133.0	COG1680@1|root,COG1680@2|Bacteria,1WJ1C@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
HKD2_k127_3497566_0	1192034.CAP_2249	7.874e-189	602.0	COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,42N87@68525|delta/epsilon subdivisions,2WV45@28221|Deltaproteobacteria,2YZDV@29|Myxococcales	28221|Deltaproteobacteria	S	ABC1 family	-	-	-	-	-	-	-	-	-	-	-	-	ABC1
HKD2_k127_3498865_1	96561.Dole_0706	3.57e-113	373.0	COG0050@1|root,COG0050@2|Bacteria,1MVC0@1224|Proteobacteria,42MWZ@68525|delta/epsilon subdivisions,2WJ2B@28221|Deltaproteobacteria,2MHTQ@213118|Desulfobacterales	28221|Deltaproteobacteria	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
HKD2_k127_3498865_2	1254432.SCE1572_03370	2.064e-74	262.0	COG2207@1|root,COG2207@2|Bacteria,1MX23@1224|Proteobacteria,42UHJ@68525|delta/epsilon subdivisions,2WT4S@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	Transcriptional Regulator, AraC family	-	-	-	-	-	-	-	-	-	-	-	-	Arabinose_bd,HTH_18
HKD2_k127_3498865_5	552811.Dehly_1718	5.289e-20	101.0	COG0515@1|root,COG0515@2|Bacteria,2GA62@200795|Chloroflexi,34D89@301297|Dehalococcoidia	301297|Dehalococcoidia	KLT	Putative auto-transporter adhesin, head GIN domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF2807
HKD2_k127_3498865_3	373994.Riv7116_4222	5.773e-42	173.0	2C0CQ@1|root,33GCQ@2|Bacteria,1G6M1@1117|Cyanobacteria	1117|Cyanobacteria	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	-	-	-	-	-	-	-	-	-	HD
HKD2_k127_3498865_0	448385.sce0127	3.386e-203	661.0	COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,1MUBY@1224|Proteobacteria,42N1K@68525|delta/epsilon subdivisions,2WIT6@28221|Deltaproteobacteria,2YZ4S@29|Myxococcales	28221|Deltaproteobacteria	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g,tRNA_bind
HKD2_k127_3541597_1	1254432.SCE1572_10000	6.006e-67	230.0	COG0508@1|root,COG0508@2|Bacteria,1MU7K@1224|Proteobacteria,42MYB@68525|delta/epsilon subdivisions,2WIUY@28221|Deltaproteobacteria,2YU5E@29|Myxococcales	28221|Deltaproteobacteria	C	acetyltransferase component of pyruvate dehydrogenase complex	pdhC	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
HKD2_k127_3541597_0	1192034.CAP_5187	9.258e-142	464.0	COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,42MGZ@68525|delta/epsilon subdivisions,2WIY6@28221|Deltaproteobacteria,2YU80@29|Myxococcales	28221|Deltaproteobacteria	JKL	Belongs to the DEAD box helicase family	-	-	3.6.4.13	ko:K11927	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DEAD,Helicase_C
HKD2_k127_3541597_2	649747.HMPREF0083_02087	4.411e-08	63.0	COG0488@1|root,COG0488@2|Bacteria,1TPAX@1239|Firmicutes,4H9TK@91061|Bacilli,26SV5@186822|Paenibacillaceae	91061|Bacilli	S	ABC transporter	yfmR	-	-	ko:K15738	-	-	-	-	ko00000,ko02000	3.A.1.120.6	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
HKD2_k127_354910_0	448385.sce5003	9.376e-189	593.0	COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,42M9W@68525|delta/epsilon subdivisions,2WJ29@28221|Deltaproteobacteria,2YUPG@29|Myxococcales	28221|Deltaproteobacteria	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	-	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
HKD2_k127_354910_1	1254432.SCE1572_22770	1.062e-68	239.0	COG4636@1|root,COG4636@2|Bacteria,1RCFH@1224|Proteobacteria,437EF@68525|delta/epsilon subdivisions,2X2KT@28221|Deltaproteobacteria,2Z042@29|Myxococcales	28221|Deltaproteobacteria	S	Putative restriction endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	Uma2
HKD2_k127_3553913_1	269799.Gmet_3159	2.164e-205	654.0	COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,42MEQ@68525|delta/epsilon subdivisions,2WIPF@28221|Deltaproteobacteria,43T5A@69541|Desulfuromonadales	28221|Deltaproteobacteria	G	Protein of unknown function (DUF3417)	glgP	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	DUF3417,Phosphorylase
HKD2_k127_3553913_6	945713.IALB_1671	1.446e-97	329.0	COG0179@1|root,COG0179@2|Bacteria	2|Bacteria	Q	Fumarylacetoacetate (FAA) hydrolase	fahA2	-	3.7.1.2	ko:K16171	ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120	M00044	R01364	RC00326,RC00446	ko00000,ko00001,ko00002,ko01000	-	-	-	FAA_hydrolase
HKD2_k127_3553913_7	1254432.SCE1572_27215	1.848e-50	183.0	COG1051@1|root,COG1051@2|Bacteria,1RA9T@1224|Proteobacteria	1224|Proteobacteria	F	NUDIX hydrolase	-	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX
HKD2_k127_3553913_3	1254432.SCE1572_26190	2.895e-112	373.0	COG0515@1|root,COG0515@2|Bacteria,1Q1TQ@1224|Proteobacteria,437GN@68525|delta/epsilon subdivisions,2X2PF@28221|Deltaproteobacteria,2YYUJ@29|Myxococcales	28221|Deltaproteobacteria	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K08884	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HKD2_k127_3553913_0	448385.sce4339	8.409e-279	885.0	COG0515@1|root,COG4885@1|root,COG0515@2|Bacteria,COG4885@2|Bacteria,1PCWS@1224|Proteobacteria,433WG@68525|delta/epsilon subdivisions,2X3VM@28221|Deltaproteobacteria,2YX9C@29|Myxococcales	28221|Deltaproteobacteria	C	Cytochrome c554 and c-prime	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3553913_8	237727.NAP1_09562	2.683e-29	137.0	COG0492@1|root,COG0664@1|root,COG1142@1|root,COG0492@2|Bacteria,COG0664@2|Bacteria,COG1142@2|Bacteria,1QUPD@1224|Proteobacteria,2TW3N@28211|Alphaproteobacteria,2K28S@204457|Sphingomonadales	204457|Sphingomonadales	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_7,Pyr_redox_2,Pyr_redox_3,cNMP_binding
HKD2_k127_3553913_2	1192034.CAP_8240	2.596e-145	497.0	COG0492@1|root,COG1146@1|root,COG0492@2|Bacteria,COG1146@2|Bacteria,1NDW6@1224|Proteobacteria,42MUD@68525|delta/epsilon subdivisions,2WKZ9@28221|Deltaproteobacteria,2YZHB@29|Myxococcales	28221|Deltaproteobacteria	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_10,Pyr_redox_3
HKD2_k127_3553913_4	1192034.CAP_8241	6.796e-104	370.0	COG2304@1|root,COG2304@2|Bacteria,1MUTS@1224|Proteobacteria,42R8X@68525|delta/epsilon subdivisions,2WN6U@28221|Deltaproteobacteria,2YWMS@29|Myxococcales	28221|Deltaproteobacteria	S	protein containing a von Willebrand factor type A (vWA) domain	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VWA
HKD2_k127_3553913_5	1192034.CAP_4308	4.147e-103	357.0	COG1409@1|root,COG1409@2|Bacteria,1R4EJ@1224|Proteobacteria	1224|Proteobacteria	S	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
HKD2_k127_3561961_7	404589.Anae109_4207	7.474e-67	254.0	COG1060@1|root,COG1427@1|root,COG1060@2|Bacteria,COG1427@2|Bacteria,1MX50@1224|Proteobacteria,42M6U@68525|delta/epsilon subdivisions,2WJ6Y@28221|Deltaproteobacteria,2YZ18@29|Myxococcales	28221|Deltaproteobacteria	H	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)	mqnC	-	1.21.98.1	ko:K11784	ko00130,ko01110,map00130,map01110	-	R08588	RC02329	ko00000,ko00001,ko01000	-	-	-	Radical_SAM
HKD2_k127_3561961_3	391625.PPSIR1_11756	3.374e-137	452.0	COG1060@1|root,COG1060@2|Bacteria,1QN23@1224|Proteobacteria,42M6Z@68525|delta/epsilon subdivisions,2WJ4C@28221|Deltaproteobacteria,2YYN9@29|Myxococcales	28221|Deltaproteobacteria	H	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate	mqnE	-	1.21.98.1,2.5.1.120,2.5.1.77	ko:K11779,ko:K11784,ko:K18285	ko00130,ko00680,ko01110,ko01120,map00130,map00680,map01110,map01120	M00378	R08588,R09396,R10667	RC00021,RC01381,RC02329,RC03002,RC03007,RC03234	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_3391	Radical_SAM
HKD2_k127_3561961_9	481448.Minf_1918	3.191e-46	183.0	COG0163@1|root,COG0163@2|Bacteria,46V9E@74201|Verrucomicrobia,37GPM@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	H	Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN	ubiX	-	2.5.1.129	ko:K03186	ko00130,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00627,map00940,map01100,map01110,map01120,map01220	M00117	R01238,R02952,R03367,R04985,R04986,R11225	RC00391,RC00814,RC03392	ko00000,ko00001,ko00002,ko01000	-	-	-	Flavoprotein
HKD2_k127_3561961_10	404589.Anae109_4204	1.363e-43	169.0	COG0500@1|root,COG2226@2|Bacteria,1MX8I@1224|Proteobacteria,42P2Z@68525|delta/epsilon subdivisions,2WNJ6@28221|Deltaproteobacteria,2YU8C@29|Myxococcales	28221|Deltaproteobacteria	H	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2)	ubiE	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Ubie_methyltran
HKD2_k127_3561961_8	448385.sce4536	4.369e-48	177.0	COG3816@1|root,COG3816@2|Bacteria,1R33P@1224|Proteobacteria,42VZ9@68525|delta/epsilon subdivisions,2WRED@28221|Deltaproteobacteria,2YVWQ@29|Myxococcales	28221|Deltaproteobacteria	S	Protein conserved in bacteria	-	-	-	ko:K09986	-	-	-	-	ko00000	-	-	-	DUF1285
HKD2_k127_3561961_2	448385.sce5802	2.174e-138	451.0	COG0111@1|root,COG3830@1|root,COG0111@2|Bacteria,COG3830@2|Bacteria,1MU5Z@1224|Proteobacteria,42M1C@68525|delta/epsilon subdivisions,2WIZQ@28221|Deltaproteobacteria,2YUM4@29|Myxococcales	28221|Deltaproteobacteria	C	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family	serA	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C,ACT
HKD2_k127_3561961_1	1232410.KI421419_gene2461	8.821e-173	568.0	COG0318@1|root,COG0318@2|Bacteria,1MUQZ@1224|Proteobacteria,42YRA@68525|delta/epsilon subdivisions,2WTWV@28221|Deltaproteobacteria,43T2E@69541|Desulfuromonadales	28221|Deltaproteobacteria	IQ	AMP-binding enzyme	-	-	6.2.1.34	ko:K12508	-	-	-	-	ko00000,ko01000	-	-	-	AMP-binding
HKD2_k127_3561961_5	1192034.CAP_5378	1.723e-83	287.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,42Q67@68525|delta/epsilon subdivisions,2WKZ1@28221|Deltaproteobacteria	1224|Proteobacteria	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HKD2_k127_3561961_11	1254432.SCE1572_34425	4.61e-27	114.0	COG0858@1|root,COG0858@2|Bacteria,1MZPE@1224|Proteobacteria,42U0Y@68525|delta/epsilon subdivisions,2WR00@28221|Deltaproteobacteria,2Z08B@29|Myxococcales	28221|Deltaproteobacteria	J	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA	rbfA	-	-	ko:K02834	-	-	-	-	ko00000,ko03009	-	-	-	RBFA
HKD2_k127_3561961_13	448385.sce5797	2.888e-21	96.0	COG1550@1|root,COG1550@2|Bacteria,1NBXZ@1224|Proteobacteria,42W9E@68525|delta/epsilon subdivisions,2WRK0@28221|Deltaproteobacteria,2YW04@29|Myxococcales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF503)	-	-	-	ko:K09764	-	-	-	-	ko00000	-	-	-	DUF503
HKD2_k127_3561961_12	1267534.KB906754_gene3877	2.722e-23	104.0	COG0071@1|root,COG0071@2|Bacteria,3Y4TM@57723|Acidobacteria,2JJFI@204432|Acidobacteriia	204432|Acidobacteriia	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
HKD2_k127_3561961_4	1192034.CAP_2502	6.453e-108	366.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,42NB6@68525|delta/epsilon subdivisions,2WIWE@28221|Deltaproteobacteria,2YXZ3@29|Myxococcales	28221|Deltaproteobacteria	M	Belongs to the peptidase S1C family	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
HKD2_k127_3561961_6	1123248.KB893370_gene5116	4.355e-82	309.0	COG2084@1|root,COG2084@2|Bacteria	2|Bacteria	I	phosphogluconate dehydrogenase (decarboxylating) activity	-	-	1.1.1.31	ko:K00020	ko00280,ko01100,map00280,map01100	-	R05066	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
HKD2_k127_3561961_0	309807.SRU_0691	1.368e-261	828.0	COG0460@1|root,COG0527@1|root,COG0460@2|Bacteria,COG0527@2|Bacteria,4NFGR@976|Bacteroidetes,1FIND@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	E	homoserine dehydrogenase	-	-	1.1.1.3,2.7.2.4	ko:K12524	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00017,M00018,M00526,M00527	R00480,R01773,R01775	RC00002,RC00043,RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT_7,Homoserine_dh,NAD_binding_3
HKD2_k127_356434_6	1121403.AUCV01000002_gene448	5.348e-20	101.0	COG4733@1|root,COG4932@1|root,COG5492@1|root,COG4733@2|Bacteria,COG4932@2|Bacteria,COG5492@2|Bacteria,1QW0V@1224|Proteobacteria,42U6C@68525|delta/epsilon subdivisions,2WQX8@28221|Deltaproteobacteria,2MN90@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Parallel beta-helix repeats	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,Big_3_2,DUF4215
HKD2_k127_356434_1	290397.Adeh_2407	2.109e-189	619.0	COG0542@1|root,COG0542@2|Bacteria,1MURH@1224|Proteobacteria,42M9S@68525|delta/epsilon subdivisions,2WJSZ@28221|Deltaproteobacteria,2YYKK@29|Myxococcales	28221|Deltaproteobacteria	O	C-terminal, D2-small domain, of ClpB protein	-	-	-	ko:K03696	ko01100,map01100	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
HKD2_k127_356434_3	448385.sce2036	5.563e-52	209.0	COG1173@1|root,COG1173@2|Bacteria,1MU26@1224|Proteobacteria,42MFP@68525|delta/epsilon subdivisions,2WJ47@28221|Deltaproteobacteria,2YV85@29|Myxococcales	28221|Deltaproteobacteria	EP	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02034,ko:K15582	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	BPD_transp_1,OppC_N
HKD2_k127_356434_2	1192034.CAP_7901	5.971e-92	321.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria	1224|Proteobacteria	P	ABC-type dipeptide oligopeptide nickel transport systems, permease components	-	-	-	ko:K02033,ko:K13890	ko02010,ko02024,map02010,map02024	M00239,M00348	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.11	-	-	BPD_transp_1
HKD2_k127_356434_0	448385.sce4837	6.469e-203	648.0	COG1109@1|root,COG1109@2|Bacteria,1QUGD@1224|Proteobacteria,43BUU@68525|delta/epsilon subdivisions,2WKYP@28221|Deltaproteobacteria,2YTV9@29|Myxococcales	28221|Deltaproteobacteria	G	Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II	-	-	5.4.2.2,5.4.2.8	ko:K01835,ko:K01840	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114,M00549	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
HKD2_k127_356434_5	1254432.SCE1572_42230	2.347e-20	92.0	COG0291@1|root,COG0291@2|Bacteria,1QDQ4@1224|Proteobacteria,42VSG@68525|delta/epsilon subdivisions,2WREY@28221|Deltaproteobacteria,2Z2C4@29|Myxococcales	28221|Deltaproteobacteria	J	Belongs to the bacterial ribosomal protein bL35 family	rpmI	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02916	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L35p
HKD2_k127_356434_4	1192034.CAP_2879	2.469e-37	143.0	COG0292@1|root,COG0292@2|Bacteria,1RGU2@1224|Proteobacteria,42REF@68525|delta/epsilon subdivisions,2WQ4F@28221|Deltaproteobacteria,2YVYH@29|Myxococcales	28221|Deltaproteobacteria	J	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit	rplT	GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015934,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904	-	ko:K02887	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L20
HKD2_k127_3578608_0	1254432.SCE1572_44170	8.631e-58	211.0	COG1664@1|root,COG1664@2|Bacteria,1MUS9@1224|Proteobacteria,43BNZ@68525|delta/epsilon subdivisions,2X70B@28221|Deltaproteobacteria,2Z3HS@29|Myxococcales	28221|Deltaproteobacteria	M	Polymer-forming cytoskeletal	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3578608_1	1254432.SCE1572_44180	5.372e-38	152.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD2_k127_3578608_2	215803.DB30_0805	6.96e-23	98.0	COG0436@1|root,COG0436@2|Bacteria,1QHKS@1224|Proteobacteria,42Z0T@68525|delta/epsilon subdivisions,2WU4I@28221|Deltaproteobacteria,2YTVA@29|Myxococcales	28221|Deltaproteobacteria	E	Aminotransferase	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
HKD2_k127_3584164_0	251221.35213066	2.174e-39	159.0	COG2135@1|root,COG2135@2|Bacteria,1G1SA@1117|Cyanobacteria	1117|Cyanobacteria	S	Belongs to the SOS response-associated peptidase family	-	-	-	-	-	-	-	-	-	-	-	-	SRAP
HKD2_k127_3584164_1	335543.Sfum_2179	2.646e-05	56.0	28HDQ@1|root,2Z7Q9@2|Bacteria,1R41M@1224|Proteobacteria,432ZX@68525|delta/epsilon subdivisions,2WY0W@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3585497_0	1243664.CAVL020000015_gene1882	5.208e-92	315.0	COG3616@1|root,COG3616@2|Bacteria,1UCX7@1239|Firmicutes,4HDKA@91061|Bacilli,1ZE8I@1386|Bacillus	91061|Bacilli	E	Alanine racemase, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Ala_racemase_N
HKD2_k127_3585497_1	886293.Sinac_2339	1.42e-13	84.0	COG4927@1|root,COG4927@2|Bacteria,2IYD9@203682|Planctomycetes	203682|Planctomycetes	M	Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase	-	-	-	-	-	-	-	-	-	-	-	-	AAT
HKD2_k127_3600186_1	243231.GSU0006	2.255e-86	306.0	COG0240@1|root,COG0240@2|Bacteria,1MUU3@1224|Proteobacteria,42NQB@68525|delta/epsilon subdivisions,2WIWW@28221|Deltaproteobacteria,43TUN@69541|Desulfuromonadales	28221|Deltaproteobacteria	I	NAD-dependent glycerol-3-phosphate dehydrogenase domain protein	gpsA	-	1.1.1.94	ko:K00057	ko00564,ko01110,map00564,map01110	-	R00842,R00844	RC00029	ko00000,ko00001,ko01000	-	-	-	NAD_Gly3P_dh_C,NAD_Gly3P_dh_N
HKD2_k127_3600186_0	1304865.JAGF01000001_gene1436	6.546e-136	442.0	COG2271@1|root,COG2271@2|Bacteria	2|Bacteria	G	transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD2_k127_363443_6	502025.Hoch_0355	3.687e-24	109.0	COG1595@1|root,COG1595@2|Bacteria,1NEJ5@1224|Proteobacteria	1224|Proteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD2_k127_363443_9	1120792.JAFV01000001_gene2714	0.0003298	53.0	COG3712@1|root,COG3712@2|Bacteria,1MZCK@1224|Proteobacteria,2U7GV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	PT	Fe2 -dicitrate sensor, membrane component	-	-	-	ko:K07165	-	-	-	-	ko00000	-	-	-	DUF4880,DUF4974,FecR
HKD2_k127_363443_7	290397.Adeh_2755	7.855e-17	94.0	2AJ10@1|root,319J4@2|Bacteria,1Q2X4@1224|Proteobacteria,438K5@68525|delta/epsilon subdivisions,2X3UQ@28221|Deltaproteobacteria,2YX5Z@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_363443_3	378806.STAUR_4439	3.438e-52	193.0	COG0204@1|root,COG0204@2|Bacteria,1MY51@1224|Proteobacteria,42QIX@68525|delta/epsilon subdivisions,2WJHE@28221|Deltaproteobacteria,2YZDA@29|Myxococcales	28221|Deltaproteobacteria	I	Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family	-	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
HKD2_k127_363443_2	1120949.KB903311_gene777	1.856e-86	294.0	2DBF0@1|root,2Z8VT@2|Bacteria,2I88D@201174|Actinobacteria,4DIBF@85008|Micromonosporales	201174|Actinobacteria	S	3-oxo-5-alpha-steroid 4-dehydrogenase	-	-	1.3.1.22	ko:K12343	ko00140,map00140	-	R02208,R02497,R08954,R10242	RC00145	ko00000,ko00001,ko01000	-	-	-	Steroid_dh
HKD2_k127_363443_8	1192034.CAP_4084	8.812e-09	67.0	COG3391@1|root,COG3391@2|Bacteria,1Q2JN@1224|Proteobacteria,4386H@68525|delta/epsilon subdivisions,2X9ZH@28221|Deltaproteobacteria,2YVZH@29|Myxococcales	28221|Deltaproteobacteria	S	Beta-L-arabinofuranosidase, GH127	-	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3,Stig1
HKD2_k127_363443_1	1121861.KB899910_gene886	2.777e-103	352.0	COG0415@1|root,COG0415@2|Bacteria,1MV9Y@1224|Proteobacteria,2TSDP@28211|Alphaproteobacteria,2JQ32@204441|Rhodospirillales	204441|Rhodospirillales	L	Belongs to the DNA photolyase family	phrB	-	4.1.99.3	ko:K01669	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_photolyase,FAD_binding_7
HKD2_k127_363443_0	1123377.AUIV01000002_gene1206	3.742e-147	502.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,1RMYC@1236|Gammaproteobacteria,1X3A2@135614|Xanthomonadales	135614|Xanthomonadales	P	COG0474 Cation transport ATPase	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
HKD2_k127_363443_5	1254432.SCE1572_27985	8.575e-27	115.0	COG0589@1|root,COG0589@2|Bacteria	2|Bacteria	T	AMP binding	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD2_k127_3656122_0	1192034.CAP_2841	2.717e-05	56.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3656122_1	448385.sce0826	0.0009501	52.0	COG1262@1|root,COG1262@2|Bacteria	2|Bacteria	T	PFAM Formylglycine-generating sulfatase enzyme	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	FGE-sulfatase,Pkinase
HKD2_k127_3659924_2	1355368.JART01000007_gene1343	3.7e-35	134.0	COG0012@1|root,COG0012@2|Bacteria,1MVM4@1224|Proteobacteria,42MNJ@68525|delta/epsilon subdivisions,2YMDC@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	J	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner	ychF	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,YchF-GTPase_C
HKD2_k127_3659924_3	861299.J421_0550	1.259e-13	78.0	2DS9Q@1|root,33F5W@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3659924_1	290397.Adeh_0078	4.171e-40	160.0	2A9VF@1|root,30Z3B@2|Bacteria,1PKZS@1224|Proteobacteria,435JG@68525|delta/epsilon subdivisions,2WZXJ@28221|Deltaproteobacteria,2Z0YG@29|Myxococcales	290397.Adeh_0078|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3659924_0	218491.ECA0736	5.006e-50	181.0	COG0667@1|root,COG0667@2|Bacteria,1MVEH@1224|Proteobacteria,1RPX5@1236|Gammaproteobacteria,1MR4H@122277|Pectobacterium	1236|Gammaproteobacteria	C	aldo keto reductase	yccK	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
HKD2_k127_367266_1	1242864.D187_010082	1.868e-93	315.0	COG0714@1|root,COG0714@2|Bacteria	2|Bacteria	KLT	Associated with various cellular activities	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_16,AAA_5,GerE
HKD2_k127_367266_2	1254432.SCE1572_51580	1.207e-34	137.0	COG0517@1|root,COG0517@2|Bacteria,1N68U@1224|Proteobacteria,42UEN@68525|delta/epsilon subdivisions,2X9VF@28221|Deltaproteobacteria,2YVE6@29|Myxococcales	28221|Deltaproteobacteria	K	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
HKD2_k127_367266_0	1192034.CAP_3564	5.137e-94	309.0	COG2006@1|root,COG2006@2|Bacteria,1NSD4@1224|Proteobacteria,42YV4@68525|delta/epsilon subdivisions,2WTK6@28221|Deltaproteobacteria,2YWVS@29|Myxococcales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
HKD2_k127_370000_2	1192034.CAP_0070	8.628e-77	278.0	COG0116@1|root,COG0116@2|Bacteria,1PB0Q@1224|Proteobacteria,4383G@68525|delta/epsilon subdivisions,2X9W5@28221|Deltaproteobacteria,2Z0CY@29|Myxococcales	28221|Deltaproteobacteria	L	Putative RNA methylase family UPF0020	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,UPF0020
HKD2_k127_370000_1	1192034.CAP_8575	3.836e-89	299.0	COG2041@1|root,COG2041@2|Bacteria,1MWZK@1224|Proteobacteria,43AZC@68525|delta/epsilon subdivisions,2WPPS@28221|Deltaproteobacteria,2YZRW@29|Myxococcales	28221|Deltaproteobacteria	S	Oxidoreductase molybdopterin binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_molyb
HKD2_k127_370000_4	1192034.CAP_8576	1.184e-63	226.0	COG3295@1|root,COG3295@2|Bacteria,1RFI2@1224|Proteobacteria,42XJC@68525|delta/epsilon subdivisions,2WSKA@28221|Deltaproteobacteria,2Z0VD@29|Myxococcales	28221|Deltaproteobacteria	S	Protein conserved in bacteria	-	-	-	ko:K09939	-	-	-	-	ko00000	-	-	-	PepSY_TM_like_2
HKD2_k127_370000_9	384765.SIAM614_11138	1.38e-06	61.0	COG1520@1|root,COG1520@2|Bacteria,1MXIJ@1224|Proteobacteria,2TUAD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	COG1520 FOG WD40-like repeat	bamB	-	-	ko:K17713	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	PQQ_2,PQQ_3
HKD2_k127_370000_0	502025.Hoch_5044	8.657e-95	328.0	2ANJD@1|root,31DIF@2|Bacteria,1QAU4@1224|Proteobacteria,43E3V@68525|delta/epsilon subdivisions,2WZMZ@28221|Deltaproteobacteria,2Z0Q6@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_370000_6	1379698.RBG1_1C00001G0853	2.9e-14	87.0	290MS@1|root,2ZNA5@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_370000_3	1242864.D187_010069	1.221e-66	248.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,42Q67@68525|delta/epsilon subdivisions,2WKZ1@28221|Deltaproteobacteria,2YUQ6@29|Myxococcales	28221|Deltaproteobacteria	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	AAA_16,Pkinase,TPR_12,zinc_ribbon_2
HKD2_k127_370000_8	536232.CLM_0418	5.334e-12	73.0	COG0671@1|root,COG0671@2|Bacteria,1VB7J@1239|Firmicutes,24JDD@186801|Clostridia,36JV0@31979|Clostridiaceae	186801|Clostridia	I	Membrane-associated phospholipid phosphatase	-	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2
HKD2_k127_374592_0	1254432.SCE1572_14680	9.633e-85	290.0	COG0642@1|root,COG2205@2|Bacteria,1P4WV@1224|Proteobacteria,43AKH@68525|delta/epsilon subdivisions,2WW5J@28221|Deltaproteobacteria,2YV4B@29|Myxococcales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	2.7.13.3	ko:K07636	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA
HKD2_k127_374592_1	1254432.SCE1572_14675	2.901e-82	279.0	COG0745@1|root,COG0745@2|Bacteria,1MU3A@1224|Proteobacteria,42QZ3@68525|delta/epsilon subdivisions,2X5BP@28221|Deltaproteobacteria,2Z2Y4@29|Myxococcales	28221|Deltaproteobacteria	K	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
HKD2_k127_37564_14	1297742.A176_06172	6.825e-15	85.0	2BPY0@1|root,32IRR@2|Bacteria,1Q1YS@1224|Proteobacteria,437KR@68525|delta/epsilon subdivisions,2X2UV@28221|Deltaproteobacteria,2YUI3@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_37564_8	1370121.AUWS01000082_gene801	7.603e-47	186.0	COG3511@1|root,COG3511@2|Bacteria,2GKPN@201174|Actinobacteria,2368C@1762|Mycobacteriaceae	201174|Actinobacteria	M	virulence factor implicated in the pathogenesis of mycobacterium tuberculosis at the level of intracellular survival, by the alteration of cell signaling events or by direct cytotoxicity catalytic activity a phosphatidylcholine H(2)O 1,2- diacylglycerol choline phosphate	plcB	GO:0003674,GO:0003824,GO:0004620,GO:0004629,GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006629,GO:0008081,GO:0008150,GO:0008152,GO:0009056,GO:0009405,GO:0016020,GO:0016042,GO:0016298,GO:0016787,GO:0016788,GO:0034480,GO:0035821,GO:0042578,GO:0044003,GO:0044238,GO:0044403,GO:0044419,GO:0044464,GO:0051701,GO:0051704,GO:0051817,GO:0052008,GO:0052043,GO:0052111,GO:0052185,GO:0052188,GO:0052368,GO:0071704,GO:0071944,GO:1901575	3.1.4.3	ko:K01114	ko00562,ko00564,ko00565,ko01100,ko01110,ko02024,ko04919,map00562,map00564,map00565,map01100,map01110,map02024,map04919	-	R01312,R02027,R02052,R03332,R07381	RC00017,RC00425	ko00000,ko00001,ko01000,ko02042	-	-	iNJ661.Rv1755c	Phosphoesterase
HKD2_k127_37564_6	1192034.CAP_8932	8.324e-58	206.0	COG3861@1|root,COG3861@2|Bacteria,1QE0P@1224|Proteobacteria,42TDZ@68525|delta/epsilon subdivisions,2WPW5@28221|Deltaproteobacteria,2Z2TG@29|Myxococcales	28221|Deltaproteobacteria	S	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_37564_0	502025.Hoch_5176	2.488e-124	424.0	COG1228@1|root,COG1228@2|Bacteria,1MY4V@1224|Proteobacteria,4383R@68525|delta/epsilon subdivisions,2X3DQ@28221|Deltaproteobacteria,2YVM1@29|Myxococcales	28221|Deltaproteobacteria	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
HKD2_k127_37564_2	1192034.CAP_0229	3.676e-96	328.0	COG2321@1|root,COG2321@2|Bacteria,1MU4U@1224|Proteobacteria,42N0U@68525|delta/epsilon subdivisions,2WJH3@28221|Deltaproteobacteria,2YXZX@29|Myxococcales	28221|Deltaproteobacteria	S	Putative neutral zinc metallopeptidase	-	-	-	ko:K07054	-	-	-	-	ko00000	-	-	-	Zn_peptidase
HKD2_k127_37564_10	1254432.SCE1572_04385	1.051e-29	126.0	COG2885@1|root,COG2885@2|Bacteria,1QAG8@1224|Proteobacteria,4352E@68525|delta/epsilon subdivisions,2WZDB@28221|Deltaproteobacteria,2Z1W3@29|Myxococcales	28221|Deltaproteobacteria	M	Belongs to the ompA family	-	-	-	ko:K03640	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	OmpA
HKD2_k127_37564_16	882.DVU_0271	1.226e-09	64.0	COG2204@1|root,COG4192@1|root,COG2204@2|Bacteria,COG4192@2|Bacteria,1R9WW@1224|Proteobacteria,42R68@68525|delta/epsilon subdivisions,2WMSV@28221|Deltaproteobacteria,2M9QN@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,Response_reg
HKD2_k127_37564_19	1193181.BN10_140021	5.65e-06	54.0	COG2771@1|root,COG2771@2|Bacteria,2I47D@201174|Actinobacteria	201174|Actinobacteria	K	PFAM regulatory protein LuxR	-	-	-	-	-	-	-	-	-	-	-	-	GerE
HKD2_k127_37564_5	76636.JOEC01000002_gene2432	4.046e-70	268.0	2EFK4@1|root,33SMD@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_37564_13	189753.AXAS01000017_gene3163	1.653e-16	81.0	2E328@1|root,32Y2G@2|Bacteria,1N9RI@1224|Proteobacteria,2UFJ4@28211|Alphaproteobacteria,3K0VA@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_37564_4	1292034.OR37_02900	6.47e-74	256.0	COG0693@1|root,COG0693@2|Bacteria,1MY0C@1224|Proteobacteria,2U5BS@28211|Alphaproteobacteria,2KGM0@204458|Caulobacterales	204458|Caulobacterales	S	DJ-1/PfpI family	-	-	3.5.1.124	ko:K05520	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	DJ-1_PfpI
HKD2_k127_37564_3	471857.Svir_34370	8.889e-94	320.0	COG1801@1|root,COG1801@2|Bacteria,2GMSP@201174|Actinobacteria,4E0MV@85010|Pseudonocardiales	201174|Actinobacteria	S	Protein of unknown function DUF72	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
HKD2_k127_37564_18	13037.EHJ68109	1.179e-07	63.0	KOG1217@1|root,KOG3594@1|root,KOG1217@2759|Eukaryota,KOG1219@2759|Eukaryota,38BUP@33154|Opisthokonta,3BA2W@33208|Metazoa,3CUNH@33213|Bilateria,41VHE@6656|Arthropoda,3SKFR@50557|Insecta,4430M@7088|Lepidoptera	33208|Metazoa	T	Epidermal growth factor-like domain.	dp	GO:0002009,GO:0002165,GO:0003674,GO:0005198,GO:0005201,GO:0005575,GO:0005576,GO:0007275,GO:0007424,GO:0007444,GO:0007472,GO:0007475,GO:0007476,GO:0007552,GO:0007560,GO:0007591,GO:0008150,GO:0008362,GO:0008587,GO:0009653,GO:0009791,GO:0009886,GO:0009887,GO:0009888,GO:0022404,GO:0031012,GO:0032501,GO:0032502,GO:0035107,GO:0035114,GO:0035120,GO:0035220,GO:0035239,GO:0035295,GO:0040003,GO:0040005,GO:0042303,GO:0042335,GO:0044421,GO:0044719,GO:0048513,GO:0048563,GO:0048569,GO:0048707,GO:0048729,GO:0048731,GO:0048736,GO:0048737,GO:0048856,GO:0060429,GO:0060541,GO:0060562,GO:0065007,GO:0065008,GO:0090066	-	-	-	-	-	-	-	-	-	-	EGF_CA
HKD2_k127_37564_12	1192034.CAP_2400	3.137e-19	102.0	COG3221@1|root,COG3221@2|Bacteria,1MXD8@1224|Proteobacteria,42VZ4@68525|delta/epsilon subdivisions,2WRDI@28221|Deltaproteobacteria,2YW4T@29|Myxococcales	28221|Deltaproteobacteria	P	ABC transporter, phosphonate, periplasmic substrate-binding protein	phnD	-	-	ko:K02044	ko02010,map02010	M00223	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.9	-	-	Phosphonate-bd
HKD2_k127_37564_9	378806.STAUR_5481	1.799e-37	147.0	COG1881@1|root,COG1881@2|Bacteria,1RHPA@1224|Proteobacteria,43ANZ@68525|delta/epsilon subdivisions	1224|Proteobacteria	S	Phosphatidylethanolamine-binding protein	-	-	-	ko:K06910	-	-	-	-	ko00000	-	-	-	PBP
HKD2_k127_37564_17	1183438.GKIL_3209	1.444e-08	67.0	COG0642@1|root,COG2205@2|Bacteria	1183438.GKIL_3209|-	T	PhoQ Sensor	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_37564_11	1163617.SCD_n00934	2.766e-22	111.0	COG3851@1|root,COG3851@2|Bacteria,1QUAD@1224|Proteobacteria	1224|Proteobacteria	T	Histidine kinase	uhpB	GO:0000155,GO:0000160,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0004721,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016311,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0016787,GO:0016788,GO:0016791,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0035556,GO:0036211,GO:0042578,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0071704,GO:0071944,GO:0140096,GO:1901564	2.7.13.3	ko:K07675,ko:K20263	ko02020,ko02024,map02020,map02024	M00473,M00818	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA_3,LapD_MoxY_N,MASE1
HKD2_k127_37564_20	1367847.JCM7686_3371	8.018e-06	58.0	COG0659@1|root,COG0659@2|Bacteria,1MVWV@1224|Proteobacteria,2TVDS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Sulfate transporter	-	-	-	ko:K03321	-	-	-	-	ko00000,ko02000	2.A.53.3	-	-	STAS,Sulfate_transp,cNMP_binding
HKD2_k127_37564_7	378806.STAUR_3199	3.28e-54	197.0	COG2085@1|root,COG2085@2|Bacteria,1PQ5W@1224|Proteobacteria,43DUZ@68525|delta/epsilon subdivisions,2WYY6@28221|Deltaproteobacteria,2Z0WT@29|Myxococcales	28221|Deltaproteobacteria	S	Rossmann-like domain	-	-	1.5.1.40	ko:K06988	-	-	-	-	ko00000,ko01000	-	-	-	F420_oxidored
HKD2_k127_37564_1	1192034.CAP_0280	1.345e-105	347.0	COG1741@1|root,COG1741@2|Bacteria,1MVSW@1224|Proteobacteria,42T87@68525|delta/epsilon subdivisions,2WP52@28221|Deltaproteobacteria,2YURQ@29|Myxococcales	28221|Deltaproteobacteria	S	Belongs to the pirin family	-	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin
HKD2_k127_377901_2	1254432.SCE1572_35450	4.015e-77	267.0	COG4464@1|root,COG4464@2|Bacteria,1R5E2@1224|Proteobacteria,42UBJ@68525|delta/epsilon subdivisions,2WQ5M@28221|Deltaproteobacteria,2YVNX@29|Myxococcales	28221|Deltaproteobacteria	GM	PFAM PHP domain protein	-	-	3.1.3.48	ko:K01104	-	-	-	-	ko00000,ko01000	-	-	-	-
HKD2_k127_377901_0	448385.sce2413	8.969e-103	347.0	COG1100@1|root,COG1100@2|Bacteria,1R6NS@1224|Proteobacteria,42NIX@68525|delta/epsilon subdivisions,2WJ44@28221|Deltaproteobacteria,2YU2F@29|Myxococcales	28221|Deltaproteobacteria	S	ADP-ribosylation factor family	-	-	-	ko:K06883	-	-	-	-	ko00000	-	-	-	Arf,Ras
HKD2_k127_377901_3	1192034.CAP_6981	1.984e-63	243.0	COG0204@1|root,COG0204@2|Bacteria,1NZER@1224|Proteobacteria,430R0@68525|delta/epsilon subdivisions,2WVS1@28221|Deltaproteobacteria,2Z112@29|Myxococcales	28221|Deltaproteobacteria	I	Diacylglycerol acyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	DAGAT
HKD2_k127_377901_4	1123321.KB905813_gene1557	2.632e-23	117.0	COG2271@1|root,COG2271@2|Bacteria,2GIS1@201174|Actinobacteria	201174|Actinobacteria	G	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
HKD2_k127_377901_1	1192034.CAP_6921	2.582e-91	327.0	COG0515@1|root,COG0515@2|Bacteria,1PFJ6@1224|Proteobacteria,4340Z@68525|delta/epsilon subdivisions,2X4J2@28221|Deltaproteobacteria,2YZ45@29|Myxococcales	28221|Deltaproteobacteria	KLT	Protein kinase domain	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
HKD2_k127_37942_1	448385.sce1915	3.645e-221	699.0	COG4715@1|root,COG4715@2|Bacteria,1RB2S@1224|Proteobacteria,437WZ@68525|delta/epsilon subdivisions,2X9Q5@28221|Deltaproteobacteria,2YUJS@29|Myxococcales	28221|Deltaproteobacteria	S	Zinc finger, swim domain protein	-	-	-	-	-	-	-	-	-	-	-	-	SWIM
HKD2_k127_37942_2	1192034.CAP_7063	2.885e-165	532.0	COG3344@1|root,COG3344@2|Bacteria,1R44F@1224|Proteobacteria,42WGB@68525|delta/epsilon subdivisions,2WQ7V@28221|Deltaproteobacteria,2YTUS@29|Myxococcales	28221|Deltaproteobacteria	L	RNA-directed DNA polymerase	-	-	2.7.7.49	ko:K00986	-	-	-	-	ko00000,ko01000	-	-	-	RVT_1
HKD2_k127_37942_8	290400.Jann_3724	1.653e-64	246.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	CMAS,Methyltransf_11,Methyltransf_25
HKD2_k127_37942_5	1163617.SCD_n00446	2.823e-83	293.0	COG4243@1|root,COG4243@2|Bacteria,1MW9C@1224|Proteobacteria,2VPG2@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Vitamin k epoxide reductase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_37942_10	1163617.SCD_n00448	9.566e-36	139.0	COG2151@1|root,COG2151@2|Bacteria,1MZ9Y@1224|Proteobacteria,2VUA0@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Iron-sulfur cluster assembly protein	-	-	-	-	-	-	-	-	-	-	-	-	FeS_assembly_P
HKD2_k127_37942_7	290397.Adeh_2133	1.102e-65	231.0	COG2846@1|root,COG2846@2|Bacteria,1MVCQ@1224|Proteobacteria,42NXK@68525|delta/epsilon subdivisions,2WMGN@28221|Deltaproteobacteria,2Z0I9@29|Myxococcales	28221|Deltaproteobacteria	C	Di-iron-containing protein involved in the repair of iron-sulfur clusters	scdA	-	-	ko:K07322	-	-	-	-	ko00000	-	-	-	Hemerythrin,ScdA_N
HKD2_k127_37942_4	1005048.CFU_1947	2.633e-85	291.0	COG2837@1|root,COG2837@2|Bacteria,1MWDD@1224|Proteobacteria,2WB49@28216|Betaproteobacteria,474Z7@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	Dyp-type peroxidase family	-	-	-	ko:K07223	-	-	-	-	ko00000	-	-	-	Dyp_perox
HKD2_k127_37942_3	1144275.COCOR_00193	2.075e-118	398.0	COG3384@1|root,COG3384@2|Bacteria,1MXJZ@1224|Proteobacteria,42Q1N@68525|delta/epsilon subdivisions,2WK3A@28221|Deltaproteobacteria,2YU8P@29|Myxococcales	28221|Deltaproteobacteria	S	Catalytic LigB subunit of aromatic ring-opening dioxygenase	ygiD	-	-	ko:K15777	ko00965,map00965	-	R08836	RC00387	ko00000,ko00001,ko01000	-	-	-	LigB
HKD2_k127_37942_6	1255043.TVNIR_0447	7.354e-75	256.0	COG1309@1|root,COG1309@2|Bacteria,1RA4T@1224|Proteobacteria,1RNQH@1236|Gammaproteobacteria,1X1EI@135613|Chromatiales	135613|Chromatiales	K	Bacterial transcriptional repressor C-terminal	-	-	-	ko:K16137	-	-	-	-	ko00000,ko03000	-	-	-	TetR_C_13,TetR_N
HKD2_k127_37942_9	713586.KB900536_gene2901	6.865e-39	149.0	COG2346@1|root,COG2346@2|Bacteria	2|Bacteria	O	COG2346, Truncated hemoglobins	glbN	-	-	ko:K06886	-	-	-	-	ko00000	-	-	-	Bac_globin
HKD2_k127_37942_0	404589.Anae109_0502	1.113e-232	731.0	COG0280@1|root,COG0281@1|root,COG0280@2|Bacteria,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,42MDI@68525|delta/epsilon subdivisions,2WIVY@28221|Deltaproteobacteria,2YXS2@29|Myxococcales	28221|Deltaproteobacteria	C	Malic enzyme, NAD binding domain	maeB	-	1.1.1.40	ko:K00029	ko00620,ko00710,ko01100,ko01120,ko01200,map00620,map00710,map01100,map01120,map01200	M00169,M00172	R00216	RC00105	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_1637	Malic_M,PTA_PTB,malic
HKD2_k127_3835923_7	215803.DB30_7342	2.368e-22	98.0	COG0583@1|root,COG0583@2|Bacteria,1QSDA@1224|Proteobacteria,437HU@68525|delta/epsilon subdivisions,2X2RC@28221|Deltaproteobacteria,2YUEZ@29|Myxococcales	28221|Deltaproteobacteria	K	LysR substrate binding domain	-	-	-	ko:K18297	-	M00641,M00745	-	-	ko00000,ko00002,ko01504,ko03000	-	-	-	HTH_1,LysR_substrate
HKD2_k127_3835923_4	502025.Hoch_6667	2.558e-101	353.0	COG0515@1|root,COG0515@2|Bacteria	502025.Hoch_6667|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3835923_5	96561.Dole_0398	5.312e-67	238.0	COG0667@1|root,COG0667@2|Bacteria	2|Bacteria	C	Aldo Keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red,HEAT_2,TetR_C_7,TetR_N
HKD2_k127_3835923_1	1454007.JAUG01000001_gene3658	8.778e-195	641.0	COG0531@1|root,COG0531@2|Bacteria,4NDU2@976|Bacteroidetes,1IPK3@117747|Sphingobacteriia	976|Bacteroidetes	E	amino acid	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease,AA_permease_2
HKD2_k127_3835923_2	716928.AJQT01000094_gene4410	7.367e-148	496.0	COG0842@1|root,COG0842@2|Bacteria,1MW5R@1224|Proteobacteria,2TU59@28211|Alphaproteobacteria,4BAH2@82115|Rhizobiaceae	28211|Alphaproteobacteria	V	ABC-2 family transporter protein	ybhR	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006855,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0015562,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0033554,GO:0042221,GO:0042493,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0071944	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
HKD2_k127_3835923_3	935557.ATYB01000008_gene5105	1.32e-147	498.0	COG0842@1|root,COG0842@2|Bacteria,1MW5R@1224|Proteobacteria,2TU59@28211|Alphaproteobacteria,4BBM0@82115|Rhizobiaceae	28211|Alphaproteobacteria	V	ABC-2 family transporter protein	ybhS	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006855,GO:0008150,GO:0015562,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0042221,GO:0042493,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071944	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
HKD2_k127_3835923_0	1432050.IE4771_CH03522	6.745e-269	843.0	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,2TR2P@28211|Alphaproteobacteria,4B9EZ@82115|Rhizobiaceae	28211|Alphaproteobacteria	V	ABC transporter, ATP-binding protein	ybhF	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006855,GO:0008150,GO:0015562,GO:0015893,GO:0016020,GO:0022857,GO:0042221,GO:0042493,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071944	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD2_k127_3835923_6	935840.JAEQ01000001_gene3025	2.126e-43	160.0	COG0845@1|root,COG0845@2|Bacteria,1MUG6@1224|Proteobacteria,2TTRG@28211|Alphaproteobacteria,43M63@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	M	Barrel-sandwich domain of CusB or HlyD membrane-fusion	-	-	-	ko:K01993	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
HKD2_k127_3836763_8	448385.sce9355	6.63e-21	98.0	COG0457@1|root,COG3266@1|root,COG0457@2|Bacteria,COG3266@2|Bacteria,1Q2SX@1224|Proteobacteria,438EQ@68525|delta/epsilon subdivisions,2X3PN@28221|Deltaproteobacteria,2YWSJ@29|Myxococcales	28221|Deltaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_6,TPR_7,TPR_8
HKD2_k127_3836763_6	2074.JNYD01000015_gene4489	7.182e-35	146.0	2BVXR@1|root,32QYG@2|Bacteria,2I832@201174|Actinobacteria,4EEBX@85010|Pseudonocardiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DoxX
HKD2_k127_3836763_7	448385.sce0866	1.162e-31	138.0	COG1082@1|root,COG1082@2|Bacteria,1QZNV@1224|Proteobacteria,43CP4@68525|delta/epsilon subdivisions,2X7WE@28221|Deltaproteobacteria,2Z239@29|Myxococcales	28221|Deltaproteobacteria	G	Xylose isomerase domain protein TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3836763_3	448385.sce0867	2.858e-123	401.0	COG1099@1|root,COG1099@2|Bacteria,1MY2H@1224|Proteobacteria,43B30@68525|delta/epsilon subdivisions,2X6GS@28221|Deltaproteobacteria,2Z3B0@29|Myxococcales	28221|Deltaproteobacteria	S	TatD related DNase	-	-	-	ko:K07051	-	-	-	-	ko00000	-	-	-	TatD_DNase
HKD2_k127_3836763_5	1254432.SCE1572_06135	1.043e-81	285.0	COG1082@1|root,COG1082@2|Bacteria,1NHXC@1224|Proteobacteria,435JR@68525|delta/epsilon subdivisions,2WZY0@28221|Deltaproteobacteria,2YWAS@29|Myxococcales	28221|Deltaproteobacteria	G	Xylose isomerase domain protein TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3836763_0	391625.PPSIR1_40340	8.094e-182	586.0	COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,42N2G@68525|delta/epsilon subdivisions,2WIXB@28221|Deltaproteobacteria,2YTZ2@29|Myxococcales	28221|Deltaproteobacteria	I	COG1022 Long-chain acyl-CoA synthetases (AMP-forming)	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
HKD2_k127_3836763_2	1192034.CAP_8580	2.154e-141	487.0	COG2114@1|root,COG2114@2|Bacteria,1NAJG@1224|Proteobacteria,4352D@68525|delta/epsilon subdivisions,2X2SX@28221|Deltaproteobacteria,2YWNC@29|Myxococcales	28221|Deltaproteobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc
HKD2_k127_3836763_1	290397.Adeh_2622	2.285e-157	503.0	COG1932@1|root,COG1932@2|Bacteria,1MUB5@1224|Proteobacteria,42MEN@68525|delta/epsilon subdivisions,2WIYF@28221|Deltaproteobacteria,2YUH6@29|Myxococcales	28221|Deltaproteobacteria	E	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine	serC	-	2.6.1.52	ko:K00831	ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230	M00020,M00124	R04173,R05085	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_5
HKD2_k127_3836763_4	1254432.SCE1572_30420	1.933e-109	363.0	COG0223@1|root,COG0223@2|Bacteria,1MU4Q@1224|Proteobacteria,42M3E@68525|delta/epsilon subdivisions,2WKMK@28221|Deltaproteobacteria,2YUSE@29|Myxococcales	28221|Deltaproteobacteria	J	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus	fmt	-	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	-	Formyl_trans_C,Formyl_trans_N
HKD2_k127_3836763_9	1688.BCUN_0154	1.759e-18	87.0	COG1201@1|root,COG1201@2|Bacteria,2GJG3@201174|Actinobacteria,4D01F@85004|Bifidobacteriales	201174|Actinobacteria	L	DEAD DEAH box helicase	lhr	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,HTH_42,Helicase_C
HKD2_k127_3837845_3	1192034.CAP_0063	6.497e-47	183.0	COG2304@1|root,COG2304@2|Bacteria,1PYZT@1224|Proteobacteria,435MP@68525|delta/epsilon subdivisions,2XA2Q@28221|Deltaproteobacteria,2YYF8@29|Myxococcales	28221|Deltaproteobacteria	S	Aerotolerance regulator N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	BatA,VWA_2
HKD2_k127_3837845_0	1192034.CAP_0062	1.601e-148	485.0	COG1721@1|root,COG1721@2|Bacteria,1NEAC@1224|Proteobacteria,43B78@68525|delta/epsilon subdivisions,2X6KP@28221|Deltaproteobacteria,2YWA8@29|Myxococcales	28221|Deltaproteobacteria	S	Von Willebrand factor type A	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
HKD2_k127_3837845_1	1254432.SCE1572_35190	6.798e-147	472.0	COG0714@1|root,COG0714@2|Bacteria,1MUFN@1224|Proteobacteria,42NCX@68525|delta/epsilon subdivisions,2WJUZ@28221|Deltaproteobacteria,2YYCD@29|Myxococcales	28221|Deltaproteobacteria	S	ATPase family associated with various cellular activities (AAA)	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
HKD2_k127_3837845_2	448385.sce5906	1.379e-71	253.0	COG1196@1|root,COG1196@2|Bacteria,1Q5CV@1224|Proteobacteria,439J1@68525|delta/epsilon subdivisions,2X4VH@28221|Deltaproteobacteria,2Z08N@29|Myxococcales	28221|Deltaproteobacteria	D	nuclear chromosome segregation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3838174_1	1254432.SCE1572_11110	8.34e-45	171.0	COG0352@1|root,COG0352@2|Bacteria,1RDSU@1224|Proteobacteria,42R5Z@68525|delta/epsilon subdivisions,2WMPN@28221|Deltaproteobacteria,2YVXC@29|Myxococcales	28221|Deltaproteobacteria	H	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)	thiE	-	2.5.1.3	ko:K00788	ko00730,ko01100,map00730,map01100	M00127	R03223,R10712	RC00224,RC03255,RC03397	ko00000,ko00001,ko00002,ko01000	-	-	-	TMP-TENI
HKD2_k127_3838174_0	1192034.CAP_3964	5.804e-83	286.0	COG2812@1|root,COG2812@2|Bacteria,1QVB3@1224|Proteobacteria,42SBC@68525|delta/epsilon subdivisions,2WPCK@28221|Deltaproteobacteria,2YVD8@29|Myxococcales	28221|Deltaproteobacteria	L	DNA polymerase III	holB	-	2.7.7.7	ko:K02341	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNApol3-delta_C
HKD2_k127_3838174_3	290397.Adeh_1968	3.77e-06	49.0	COG2204@1|root,COG2204@2|Bacteria	2|Bacteria	T	phosphorelay signal transduction system	-	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	HATPase_c_2,HTH_8,Response_reg,Sigma54_activ_2,Sigma54_activat
HKD2_k127_3849486_3	264732.Moth_1737	3.624e-48	176.0	COG0338@1|root,COG0338@2|Bacteria,1TRDX@1239|Firmicutes,25E75@186801|Clostridia,42G63@68295|Thermoanaerobacterales	186801|Clostridia	H	PFAM D12 class N6 adenine-specific DNA methyltransferase	dam	-	2.1.1.72	ko:K06223	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko02048,ko03032,ko03400	-	-	-	MethyltransfD12
HKD2_k127_3849486_4	1254432.SCE1572_40985	1.953e-46	181.0	COG0212@1|root,COG0212@2|Bacteria,1MZG0@1224|Proteobacteria,42U47@68525|delta/epsilon subdivisions,2WQXE@28221|Deltaproteobacteria,2YVV5@29|Myxococcales	28221|Deltaproteobacteria	H	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family	-	-	6.3.3.2	ko:K01934	ko00670,ko01100,map00670,map01100	-	R02301	RC00183	ko00000,ko00001,ko01000	-	-	-	5-FTHF_cyc-lig
HKD2_k127_3849486_2	448385.sce0007	4.072e-58	208.0	COG0735@1|root,COG0735@2|Bacteria,1RDWJ@1224|Proteobacteria,42MN8@68525|delta/epsilon subdivisions,2WQKR@28221|Deltaproteobacteria,2YVE5@29|Myxococcales	28221|Deltaproteobacteria	K	Belongs to the Fur family	fur	-	-	ko:K03711	-	-	-	-	ko00000,ko03000	-	-	-	FUR
HKD2_k127_3849486_1	1254432.SCE1572_12420	1.577e-89	300.0	COG0607@1|root,COG3118@1|root,COG0607@2|Bacteria,COG3118@2|Bacteria	2|Bacteria	O	belongs to the thioredoxin family	-	-	2.8.1.7,4.4.1.16	ko:K03671,ko:K05838,ko:K07390,ko:K11717	ko00450,ko01100,ko04621,ko05418,map00450,map01100,map04621,map05418	-	R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000,ko03029,ko03110	-	-	-	Aminotran_5,Rhodanese,TPR_19,TPR_20,Thioredoxin
HKD2_k127_3849486_0	448385.sce8438	4.988e-94	316.0	COG0484@1|root,COG0484@2|Bacteria	2|Bacteria	O	heat shock protein binding	dnaJ	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
HKD2_k127_3853938_5	1192034.CAP_9041	2.189e-22	109.0	COG4870@1|root,COG4870@2|Bacteria	2|Bacteria	O	transferase activity, transferring glycosyl groups	-	-	3.4.22.15	ko:K01365,ko:K14475	ko04140,ko04142,ko04145,ko04210,ko04612,ko05143,ko05205,ko05323,ko05418,map04140,map04142,map04145,map04210,map04612,map05143,map05205,map05323,map05418	-	-	-	ko00000,ko00001,ko00537,ko01000,ko01002,ko03110	-	-	-	Inhibitor_I42,Peptidase_C1
HKD2_k127_3853938_8	426114.THI_0284	9.437e-05	51.0	COG1846@1|root,COG1846@2|Bacteria,1PC0C@1224|Proteobacteria,2VUH3@28216|Betaproteobacteria	28216|Betaproteobacteria	K	PFAM regulatory protein, MarR	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
HKD2_k127_3853938_3	448385.sce3719	1.358e-74	260.0	COG1208@1|root,COG1208@2|Bacteria,1R9ZD@1224|Proteobacteria,42SI2@68525|delta/epsilon subdivisions,2WQPV@28221|Deltaproteobacteria,2YVRY@29|Myxococcales	28221|Deltaproteobacteria	JM	Nucleotidyl transferase	-	-	2.7.7.13	ko:K00966	ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110	M00114,M00361,M00362	R00885	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
HKD2_k127_3853938_6	1144275.COCOR_02604	3.936e-07	62.0	COG1409@1|root,COG1409@2|Bacteria	2|Bacteria	S	acid phosphatase activity	-	-	3.1.4.53	ko:K03651	ko00230,ko02025,map00230,map02025	-	R00191	RC00296	ko00000,ko00001,ko01000	-	-	-	Big_4,F5_F8_type_C,Laminin_G_3,Metallophos
HKD2_k127_3853938_4	1192034.CAP_0049	2.587e-41	158.0	2BT02@1|root,32N40@2|Bacteria,1Q3JG@1224|Proteobacteria,439CC@68525|delta/epsilon subdivisions,2X4KJ@28221|Deltaproteobacteria,2Z05X@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440
HKD2_k127_3853938_2	1254432.SCE1572_46790	8.349e-83	278.0	COG0317@1|root,COG0317@2|Bacteria,1RGUA@1224|Proteobacteria,435HG@68525|delta/epsilon subdivisions,2WZV2@28221|Deltaproteobacteria,2Z2TB@29|Myxococcales	28221|Deltaproteobacteria	KT	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	HD_4
HKD2_k127_3853938_0	232721.Ajs_1057	6.162e-218	685.0	COG0114@1|root,COG0114@2|Bacteria,1MUQI@1224|Proteobacteria,2VHA5@28216|Betaproteobacteria,4AAGV@80864|Comamonadaceae	28216|Betaproteobacteria	C	Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate	fumC	-	4.2.1.2	ko:K01679	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211	M00009,M00011,M00173,M00376	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	FumaraseC_C,Lyase_1
HKD2_k127_3853938_1	448385.sce5920	4.556e-120	404.0	COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,42MUZ@68525|delta/epsilon subdivisions,2WJT6@28221|Deltaproteobacteria,2YXTZ@29|Myxococcales	28221|Deltaproteobacteria	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	-	-	2.3.1.179,2.3.1.41	ko:K00647,ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
HKD2_k127_3856559_1	290397.Adeh_0588	1.32e-72	258.0	COG0002@1|root,COG0002@2|Bacteria,1MVJ6@1224|Proteobacteria,42MDN@68525|delta/epsilon subdivisions,2WINX@28221|Deltaproteobacteria,2YTTI@29|Myxococcales	28221|Deltaproteobacteria	E	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde	argC	-	1.2.1.38	ko:K00145,ko:K05829	ko00220,ko00300,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01130,map01210,map01230	M00028,M00031,M00763,M00845	R03443,R09777,R10931	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
HKD2_k127_3856559_0	404589.Anae109_0632	7.556e-153	494.0	COG0548@1|root,COG1364@1|root,COG0548@2|Bacteria,COG1364@2|Bacteria,1MU0T@1224|Proteobacteria,42M6S@68525|delta/epsilon subdivisions,2WJU8@28221|Deltaproteobacteria,2YV2H@29|Myxococcales	28221|Deltaproteobacteria	E	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate	-	-	2.3.1.1,2.3.1.35,2.7.2.8	ko:K00620,ko:K00930	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259,R02282,R02649	RC00002,RC00004,RC00043,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ArgJ
HKD2_k127_3858849_1	861299.J421_1669	4.45e-91	310.0	COG0623@1|root,COG0623@2|Bacteria,1ZTGW@142182|Gemmatimonadetes	142182|Gemmatimonadetes	I	Enoyl-(Acyl carrier protein) reductase	-	-	1.3.1.10,1.3.1.9	ko:K00208	ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212	M00083,M00572	R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671	RC00052,RC00076,RC00120	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HKD2_k127_3858849_0	926550.CLDAP_36730	5.04e-167	533.0	COG1960@1|root,COG1960@2|Bacteria,2G5J5@200795|Chloroflexi	200795|Chloroflexi	I	Acyl-CoA dehydrogenase, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HKD2_k127_3858849_2	313612.L8106_23246	2.781e-83	282.0	COG1226@1|root,COG1226@2|Bacteria,1G2MJ@1117|Cyanobacteria,1H8TX@1150|Oscillatoriales	1117|Cyanobacteria	P	k transport	-	-	-	ko:K10716	-	-	-	-	ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	Ion_trans,TrkA_N
HKD2_k127_3859405_2	1192034.CAP_4451	1.099e-26	112.0	2DQMB@1|root,337KD@2|Bacteria,1NKJH@1224|Proteobacteria,42X0X@68525|delta/epsilon subdivisions,2WSJT@28221|Deltaproteobacteria,2YVNT@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3859405_0	1254432.SCE1572_38500	1.129e-131	436.0	COG2304@1|root,COG2304@2|Bacteria,1MXQ7@1224|Proteobacteria,42NWB@68525|delta/epsilon subdivisions,2WKKE@28221|Deltaproteobacteria,2YXC9@29|Myxococcales	28221|Deltaproteobacteria	S	protein containing a von Willebrand factor type A (vWA) domain	batA	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	BatA,VWA
HKD2_k127_3859405_1	1192034.CAP_4449	7.416e-113	393.0	COG2304@1|root,COG2304@2|Bacteria,1MW51@1224|Proteobacteria,42M45@68525|delta/epsilon subdivisions,2WM19@28221|Deltaproteobacteria,2YV46@29|Myxococcales	28221|Deltaproteobacteria	S	protein containing a von Willebrand factor type A (vWA) domain	batB	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	BatA,TPR_1,TPR_16,TPR_2,VWA,VWA_2
HKD2_k127_3859405_3	1192034.CAP_4448	5.039e-25	108.0	COG0457@1|root,COG0457@2|Bacteria,1PYTB@1224|Proteobacteria,42VYS@68525|delta/epsilon subdivisions,2XA0E@28221|Deltaproteobacteria,2YW26@29|Myxococcales	28221|Deltaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_2
HKD2_k127_3861638_1	502025.Hoch_1972	1.546e-58	210.0	COG1430@1|root,COG1430@2|Bacteria	2|Bacteria	S	Uncharacterized ACR, COG1430	-	-	-	ko:K09005	-	-	-	-	ko00000	-	-	-	DUF192
HKD2_k127_3861638_0	502025.Hoch_1973	3.679e-94	336.0	COG5316@1|root,COG5316@2|Bacteria,1N0IJ@1224|Proteobacteria,43BYT@68525|delta/epsilon subdivisions,2WMTY@28221|Deltaproteobacteria,2YUVR@29|Myxococcales	28221|Deltaproteobacteria	S	N-terminal domain of unknown function (DUF4140)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4139,DUF4140
HKD2_k127_3863227_0	330214.NIDE0726	3.487e-61	214.0	COG0841@1|root,COG0841@2|Bacteria,3J0ZG@40117|Nitrospirae	40117|Nitrospirae	V	AcrB/AcrD/AcrF family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
HKD2_k127_3863227_1	1254432.SCE1572_21880	1.65e-24	117.0	COG1538@1|root,COG1538@2|Bacteria,1PDKT@1224|Proteobacteria,4398W@68525|delta/epsilon subdivisions,2X4G7@28221|Deltaproteobacteria,2YYYH@29|Myxococcales	28221|Deltaproteobacteria	MU	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
HKD2_k127_387324_1	1254432.SCE1572_44485	2.465e-176	571.0	COG2366@1|root,COG2366@2|Bacteria,1MVMH@1224|Proteobacteria,42M9A@68525|delta/epsilon subdivisions,2WJ3Y@28221|Deltaproteobacteria,2YUEP@29|Myxococcales	28221|Deltaproteobacteria	S	Penicillin amidase	-	-	3.5.1.11	ko:K01434	ko00311,ko01130,map00311,map01130	-	R02170	RC00166,RC00328	ko00000,ko00001,ko01000,ko01002	-	-	-	Penicil_amidase
HKD2_k127_387324_0	448385.sce3440	3.123e-194	643.0	COG1033@1|root,COG1033@2|Bacteria,1R0CG@1224|Proteobacteria,43CUX@68525|delta/epsilon subdivisions,2X9DC@28221|Deltaproteobacteria,2Z3JS@29|Myxococcales	28221|Deltaproteobacteria	S	MMPL family	-	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
HKD2_k127_3873554_0	471854.Dfer_1108	2.145e-23	113.0	COG0664@1|root,COG3202@1|root,COG0664@2|Bacteria,COG3202@2|Bacteria,4NIB2@976|Bacteroidetes,47JM4@768503|Cytophagia	976|Bacteroidetes	CT	Cyclic nucleotide-monophosphate binding domain	-	-	-	ko:K03301	-	-	-	-	ko00000	2.A.12	-	-	TLC,cNMP_binding
HKD2_k127_3873554_1	448385.sce4835	1.22e-22	100.0	COG0820@1|root,COG0820@2|Bacteria,1MUYK@1224|Proteobacteria,42N69@68525|delta/epsilon subdivisions,2WIUJ@28221|Deltaproteobacteria,2YURZ@29|Myxococcales	28221|Deltaproteobacteria	J	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs	rlmN	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140101,GO:0140102,GO:1901360	2.1.1.192	ko:K06941	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Fer4_14,Radical_SAM
HKD2_k127_3874668_7	690850.Desaf_0494	1.274e-21	106.0	COG3202@1|root,COG3202@2|Bacteria,1MVP5@1224|Proteobacteria,42MNS@68525|delta/epsilon subdivisions,2WSQX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	ATP ADP translocase	-	-	-	ko:K03301	-	-	-	-	ko00000	2.A.12	-	-	MFS_1,TLC
HKD2_k127_3874668_0	448385.sce7909	2.706e-242	778.0	COG0574@1|root,COG3848@1|root,COG0574@2|Bacteria,COG3848@2|Bacteria	2|Bacteria	GT	kinase activity	ppsA	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PPDK_N
HKD2_k127_3874668_5	448385.sce7908	3.918e-44	171.0	COG0564@1|root,COG0564@2|Bacteria	2|Bacteria	J	pseudouridine synthase activity	-	-	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
HKD2_k127_3874668_9	1227497.C491_08248	5.115e-05	53.0	COG3361@1|root,arCOG04579@2157|Archaea,2XUTP@28890|Euryarchaeota,23SUQ@183963|Halobacteria	183963|Halobacteria	S	Uncharacterized conserved protein (COG2071)	-	-	-	ko:K09166	-	-	-	-	ko00000	-	-	-	DUF2071
HKD2_k127_3874668_1	1254432.SCE1572_42315	1.966e-117	408.0	COG0457@1|root,COG0515@1|root,COG1262@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG1262@2|Bacteria,1Q53R@1224|Proteobacteria,430W1@68525|delta/epsilon subdivisions,2WVP7@28221|Deltaproteobacteria,2YWDG@29|Myxococcales	28221|Deltaproteobacteria	KLT	Sulfatase-modifying factor enzyme 1	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	FGE-sulfatase,Pkinase
HKD2_k127_3874668_3	1254432.SCE1572_18245	2.152e-64	226.0	COG3066@1|root,COG3066@2|Bacteria,1MVYX@1224|Proteobacteria	1224|Proteobacteria	L	Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair	mutH	GO:0000018,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009036,GO:0009987,GO:0015666,GO:0016787,GO:0016788,GO:0016888,GO:0016893,GO:0019219,GO:0019222,GO:0031323,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0043765,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051171,GO:0051716,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1990391	-	ko:K03573	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutH
HKD2_k127_3874668_2	1111479.AXAR01000009_gene2402	2.211e-76	291.0	COG3391@1|root,COG3511@1|root,COG3391@2|Bacteria,COG3511@2|Bacteria,1V255@1239|Firmicutes,4HFUF@91061|Bacilli	91061|Bacilli	M	40-residue YVTN family beta-propeller repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	Collagen,Cytochrom_D1,Lactonase,Phosphoesterase
HKD2_k127_3874668_6	378806.STAUR_7300	8.916e-31	126.0	COG3012@1|root,COG3012@2|Bacteria,1Q5V3@1224|Proteobacteria,42UFW@68525|delta/epsilon subdivisions,2WYUQ@28221|Deltaproteobacteria,2Z0NT@29|Myxococcales	28221|Deltaproteobacteria	S	SEC-C Motif Domain Protein	-	-	-	ko:K09858	-	-	-	-	ko00000	-	-	-	SEC-C
HKD2_k127_3874668_4	575540.Isop_1590	1.836e-60	235.0	COG3391@1|root,COG3391@2|Bacteria,2IX7F@203682|Planctomycetes	203682|Planctomycetes	M	Phosphoesterase family	-	-	-	-	-	-	-	-	-	-	-	-	Lactonase,Phosphoesterase
HKD2_k127_3878290_8	448385.sce0520	1.163e-20	103.0	COG3391@1|root,COG3391@2|Bacteria,1R0BE@1224|Proteobacteria,43CTP@68525|delta/epsilon subdivisions,2X817@28221|Deltaproteobacteria,2Z05E@29|Myxococcales	28221|Deltaproteobacteria	E	Stigma-specific protein, Stig1	-	-	-	-	-	-	-	-	-	-	-	-	Stig1
HKD2_k127_3878290_9	1121033.AUCF01000011_gene1858	1.359e-13	83.0	COG2010@1|root,COG2010@2|Bacteria,1MV6D@1224|Proteobacteria,2TT9U@28211|Alphaproteobacteria,2JWAD@204441|Rhodospirillales	204441|Rhodospirillales	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C
HKD2_k127_3878290_10	1120705.FG95_00706	4.067e-10	70.0	COG0583@1|root,COG0583@2|Bacteria,1MW16@1224|Proteobacteria,2TVB7@28211|Alphaproteobacteria,2K9CF@204457|Sphingomonadales	204457|Sphingomonadales	K	Bacterial regulatory helix-turn-helix protein, lysR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HKD2_k127_3878290_3	448385.sce4543	1.328e-90	316.0	COG0515@1|root,COG0515@2|Bacteria,1QA6R@1224|Proteobacteria,43ARV@68525|delta/epsilon subdivisions,2X65Y@28221|Deltaproteobacteria,2Z39J@29|Myxococcales	448385.sce4543|-	KLT	Family membership	-	-	2.7.11.1	ko:K08884	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	-
HKD2_k127_3878290_1	1192034.CAP_4442	1.716e-117	396.0	COG0515@1|root,COG0515@2|Bacteria	1192034.CAP_4442|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3878290_2	502025.Hoch_6640	3.61e-94	320.0	COG0399@1|root,COG0399@2|Bacteria,1MUPN@1224|Proteobacteria,42M4C@68525|delta/epsilon subdivisions,2WJ1Q@28221|Deltaproteobacteria,2YYNR@29|Myxococcales	28221|Deltaproteobacteria	M	Belongs to the DegT DnrJ EryC1 family	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
HKD2_k127_3878290_4	483219.LILAB_19620	3.646e-79	277.0	COG0745@1|root,COG0784@1|root,COG4191@1|root,COG0745@2|Bacteria,COG0784@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42PZ5@68525|delta/epsilon subdivisions,2WM5Q@28221|Deltaproteobacteria,2Z2WF@29|Myxococcales	28221|Deltaproteobacteria	T	PAS fold	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_4,PAS_8,PAS_9,Response_reg
HKD2_k127_3878290_7	649747.HMPREF0083_02082	4.902e-33	141.0	COG2855@1|root,COG2855@2|Bacteria,1TQYA@1239|Firmicutes,4HCCP@91061|Bacilli,26R0S@186822|Paenibacillaceae	91061|Bacilli	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	Cons_hypoth698
HKD2_k127_3878290_0	391625.PPSIR1_26988	2.239e-119	394.0	COG0491@1|root,COG0491@2|Bacteria,1MURA@1224|Proteobacteria,42P5T@68525|delta/epsilon subdivisions,2WM91@28221|Deltaproteobacteria,2Z2Z9@29|Myxococcales	28221|Deltaproteobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HKD2_k127_3883553_4	391625.PPSIR1_13810	4.762e-71	245.0	COG0604@1|root,COG0604@2|Bacteria,1MWRK@1224|Proteobacteria	1224|Proteobacteria	C	COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases	MA20_32380	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
HKD2_k127_3883553_3	502025.Hoch_4372	1.688e-73	256.0	COG1073@1|root,COG1073@2|Bacteria,1NX86@1224|Proteobacteria,42QXW@68525|delta/epsilon subdivisions,2WN43@28221|Deltaproteobacteria,2YZ5P@29|Myxococcales	28221|Deltaproteobacteria	S	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
HKD2_k127_3883553_0	1244869.H261_06801	6.708e-187	618.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2TR3P@28211|Alphaproteobacteria,2JRE7@204441|Rhodospirillales	204441|Rhodospirillales	I	COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
HKD2_k127_3883553_6	1205680.CAKO01000002_gene2387	3.532e-59	223.0	COG5361@1|root,COG5361@2|Bacteria,1MWTW@1224|Proteobacteria,2TUR1@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1254)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1214,DUF1254
HKD2_k127_3883553_8	2002.JOEQ01000004_gene3077	3.476e-22	111.0	2BVXS@1|root,334C2@2|Bacteria,2GSH2@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3883553_5	383372.Rcas_0264	1.915e-60	230.0	COG5184@1|root,COG5184@2|Bacteria,2G8WU@200795|Chloroflexi,3765G@32061|Chloroflexia	32061|Chloroflexia	DZ	PFAM regulator of chromosome condensation, RCC1	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3883553_2	1254432.SCE1572_34415	1.44e-105	353.0	COG1086@1|root,COG1215@1|root,COG1086@2|Bacteria,COG1215@2|Bacteria,1R988@1224|Proteobacteria,42QGX@68525|delta/epsilon subdivisions,2WJPU@28221|Deltaproteobacteria,2YV0M@29|Myxococcales	28221|Deltaproteobacteria	M	Glycosyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HKD2_k127_3883553_1	1382356.JQMP01000003_gene2301	1.727e-147	480.0	COG1488@1|root,COG1488@2|Bacteria,2GAK8@200795|Chloroflexi,27YGV@189775|Thermomicrobia	189775|Thermomicrobia	H	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP	-	-	6.3.4.21	ko:K00763	ko00760,ko01100,map00760,map01100	-	R01724	RC00033	ko00000,ko00001,ko01000	-	-	-	NAPRTase
HKD2_k127_3883553_7	717774.Marme_2599	1.136e-32	129.0	COG0243@1|root,COG0243@2|Bacteria,1MU6B@1224|Proteobacteria,1RNXW@1236|Gammaproteobacteria,1XIPP@135619|Oceanospirillales	135619|Oceanospirillales	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Molybdopterin,Molydop_binding
HKD2_k127_3884075_0	216596.RL3680	4.61e-56	214.0	COG0845@1|root,COG0845@2|Bacteria,1MUG6@1224|Proteobacteria,2TTRG@28211|Alphaproteobacteria,4BARW@82115|Rhizobiaceae	28211|Alphaproteobacteria	M	secretion protein	-	-	-	ko:K01993	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
HKD2_k127_3884075_2	264198.Reut_A0754	1.279e-49	184.0	COG1309@1|root,COG1309@2|Bacteria,1MWKF@1224|Proteobacteria,2W9FC@28216|Betaproteobacteria,1KD6U@119060|Burkholderiaceae	28216|Betaproteobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
HKD2_k127_3884075_1	338969.Rfer_0785	2.762e-53	195.0	COG4262@1|root,COG4262@2|Bacteria,1QTYC@1224|Proteobacteria,2VK9Z@28216|Betaproteobacteria,4ABE1@80864|Comamonadaceae	28216|Betaproteobacteria	S	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	speE	-	2.5.1.16	ko:K00797	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	M00034,M00133	R01920,R02869,R08359	RC00021,RC00053	ko00000,ko00001,ko00002,ko01000	-	-	-	Spermine_synth
HKD2_k127_3884075_3	448385.sce1508	2.945e-32	142.0	COG4262@1|root,COG4262@2|Bacteria,1PD57@1224|Proteobacteria,43EWI@68525|delta/epsilon subdivisions,2X2BM@28221|Deltaproteobacteria,2YZ47@29|Myxococcales	28221|Deltaproteobacteria	S	Spermine/spermidine synthase domain	-	-	-	-	-	-	-	-	-	-	-	-	Spermine_synth
HKD2_k127_3885752_2	1254432.SCE1572_11095	1.078e-65	226.0	COG3246@1|root,COG3246@2|Bacteria,1MZTP@1224|Proteobacteria,42QYC@68525|delta/epsilon subdivisions,2WN66@28221|Deltaproteobacteria,2Z2W4@29|Myxococcales	28221|Deltaproteobacteria	S	Pfam:Kce	-	-	-	-	-	-	-	-	-	-	-	-	BKACE
HKD2_k127_3885752_1	1254432.SCE1572_11100	4.547e-87	302.0	COG1024@1|root,COG1024@2|Bacteria,1MUJ7@1224|Proteobacteria,42RTA@68525|delta/epsilon subdivisions,2WNCA@28221|Deltaproteobacteria,2YV29@29|Myxococcales	28221|Deltaproteobacteria	I	enoyl-CoA hydratase isomerase family	-	-	4.2.1.17	ko:K01692	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
HKD2_k127_3885752_0	1192034.CAP_7981	8.594e-285	891.0	COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,43AEE@68525|delta/epsilon subdivisions,2WIRF@28221|Deltaproteobacteria,2YWJZ@29|Myxococcales	28221|Deltaproteobacteria	I	Carboxyl transferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Carboxyl_trans
HKD2_k127_3892910_0	1192034.CAP_6526	1.358e-189	605.0	COG1007@1|root,COG1007@2|Bacteria,1MV56@1224|Proteobacteria,42P7Z@68525|delta/epsilon subdivisions,2WK06@28221|Deltaproteobacteria,2YU3N@29|Myxococcales	28221|Deltaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoN	-	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
HKD2_k127_3892910_1	1254432.SCE1572_25600	1.029e-177	567.0	COG1008@1|root,COG1008@2|Bacteria,1MV7V@1224|Proteobacteria,42NGD@68525|delta/epsilon subdivisions,2WJDC@28221|Deltaproteobacteria,2YTXZ@29|Myxococcales	28221|Deltaproteobacteria	C	Proton-conducting membrane transporter	nuoM	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q5_N,Proton_antipo_M
HKD2_k127_3897957_0	391625.PPSIR1_34792	1.836e-98	342.0	COG0318@1|root,COG3243@1|root,COG0318@2|Bacteria,COG3243@2|Bacteria,1MWSD@1224|Proteobacteria,42Q72@68525|delta/epsilon subdivisions,2WM9N@28221|Deltaproteobacteria	28221|Deltaproteobacteria	IQ	PFAM AMP-dependent synthetase and ligase	-	-	6.2.1.48	ko:K02182	-	-	-	-	ko00000,ko01000	-	-	-	AMP-binding,AMP-binding_C
HKD2_k127_3900758_0	1192034.CAP_2703	1.266e-284	889.0	COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,42MHD@68525|delta/epsilon subdivisions,2WTUX@28221|Deltaproteobacteria,2YTTM@29|Myxococcales	28221|Deltaproteobacteria	M	Belongs to the peptidase S41A family	-	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_S41
HKD2_k127_3903484_1	1121920.AUAU01000008_gene1590	7.725e-93	330.0	COG0167@1|root,COG0167@2|Bacteria,3Y464@57723|Acidobacteria	57723|Acidobacteria	F	Catalyzes the conversion of dihydroorotate to orotate	-	-	1.3.98.1	ko:K00226	ko00240,ko01100,map00240,map01100	M00051	R01867	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
HKD2_k127_3903484_0	1121920.AUAU01000008_gene1589	0.0	1545.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1149@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1149@2|Bacteria,3Y415@57723|Acidobacteria	57723|Acidobacteria	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	-	-	1.2.7.1	ko:K03737	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00173,M00307	R01196,R10866	RC00004,RC02742	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	EKR,Fer4_16,PFOR_II,POR,POR_N,TPP_enzyme_C
HKD2_k127_3903484_2	1254432.SCE1572_34115	3.252e-56	199.0	COG0823@1|root,COG0823@2|Bacteria,1RI0N@1224|Proteobacteria	1224|Proteobacteria	U	PA14 domain	-	-	-	-	-	-	-	-	-	-	-	-	PA14,VPEP
HKD2_k127_3904026_1	378806.STAUR_7260	9.611e-102	340.0	COG1109@1|root,COG1109@2|Bacteria,1MUA5@1224|Proteobacteria,42MET@68525|delta/epsilon subdivisions,2WITH@28221|Deltaproteobacteria,2YUC2@29|Myxococcales	28221|Deltaproteobacteria	G	Phosphoglucomutase/phosphomannomutase, C-terminal domain	algC	-	5.4.2.2,5.4.2.8	ko:K01840,ko:K15778	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
HKD2_k127_3904026_0	1144275.COCOR_00645	3.997e-104	357.0	COG4395@1|root,COG4395@2|Bacteria	2|Bacteria	S	Tim44	MA20_24770	-	-	ko:K15539	-	-	-	-	ko00000	-	-	-	Tim44
HKD2_k127_3904026_3	1144275.COCOR_00644	6.966e-21	106.0	COG3762@1|root,COG3762@2|Bacteria,1R61N@1224|Proteobacteria,42QZE@68525|delta/epsilon subdivisions	1224|Proteobacteria	S	Membrane	-	-	-	ko:K08988	-	-	-	-	ko00000	-	-	-	TPM_phosphatase
HKD2_k127_3904026_2	1144275.COCOR_06119	3.25e-21	105.0	COG1454@1|root,COG1454@2|Bacteria,1MVPH@1224|Proteobacteria,42MBY@68525|delta/epsilon subdivisions,2WIR5@28221|Deltaproteobacteria,2YUKC@29|Myxococcales	28221|Deltaproteobacteria	C	alcohol dehydrogenase	-	-	1.1.1.61	ko:K00043	ko00650,ko01100,ko01200,map00650,map01100,map01200	-	R01644	RC00087	ko00000,ko00001,ko01000	-	-	-	Fe-ADH
HKD2_k127_3904810_1	1267535.KB906767_gene4668	2.061e-69	243.0	COG1215@1|root,COG1215@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	GlcNAc,Glycos_transf_2
HKD2_k127_3904810_3	1254432.SCE1572_39025	4.33e-13	83.0	29WSY@1|root,30IEA@2|Bacteria,1PV9U@1224|Proteobacteria,438BH@68525|delta/epsilon subdivisions,2X3KW@28221|Deltaproteobacteria,2YWGD@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3904810_0	483219.LILAB_03275	2.11e-80	273.0	COG2009@1|root,COG2009@2|Bacteria,1R7RY@1224|Proteobacteria,4329Z@68525|delta/epsilon subdivisions,2WYFY@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Succinate dehydrogenase/Fumarate reductase transmembrane subunit	sdhC	-	-	ko:K00241	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	Sdh_cyt
HKD2_k127_3904810_4	1192034.CAP_8242	7.042e-12	79.0	COG1506@1|root,COG1506@2|Bacteria	2|Bacteria	E	serine-type peptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	AXE1,Peptidase_S9
HKD2_k127_3904810_2	1203606.HMPREF1526_01507	3.23e-26	121.0	COG0707@1|root,COG0707@2|Bacteria,1UQ6A@1239|Firmicutes,248FR@186801|Clostridia,36F7T@31979|Clostridiaceae	186801|Clostridia	M	Monogalactosyldiacylglycerol synthase	-	-	2.4.1.315	ko:K03429	ko00561,ko01100,map00561,map01100	-	R02689,R04377	RC00005,RC00059	ko00000,ko00001,ko01000,ko01003	-	GT28	-	Glyco_tran_28_C,Glycos_transf_1,MGDG_synth
HKD2_k127_3907157_2	502025.Hoch_3976	5.344e-26	116.0	COG3118@1|root,COG3118@2|Bacteria	2|Bacteria	O	belongs to the thioredoxin family	bcsC	-	1.8.1.9,2.7.11.1	ko:K00384,ko:K02453,ko:K11912,ko:K20543	ko00450,ko02025,ko03070,ko05111,map00450,map02025,map03070,map05111	M00331	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko00002,ko01000,ko01001,ko02000,ko02044	1.B.55.3,3.A.15	-	-	BCSC_C,NfrA_C,TPR_16,TPR_19,TPR_8
HKD2_k127_3907157_1	886293.Sinac_3762	3.855e-44	183.0	COG0662@1|root,COG2207@1|root,COG0662@2|Bacteria,COG2207@2|Bacteria,2IZ1I@203682|Planctomycetes	203682|Planctomycetes	K	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18,PAS_4
HKD2_k127_3907157_0	1192034.CAP_2788	1.114e-110	371.0	COG0515@1|root,COG0515@2|Bacteria,1QTCV@1224|Proteobacteria,437W9@68525|delta/epsilon subdivisions,2X35U@28221|Deltaproteobacteria,2YUE8@29|Myxococcales	28221|Deltaproteobacteria	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HKD2_k127_3908261_0	1123269.NX02_01920	0.0	1314.0	COG3459@1|root,COG3459@2|Bacteria,1MVNX@1224|Proteobacteria,2TSAJ@28211|Alphaproteobacteria,2K0DW@204457|Sphingomonadales	204457|Sphingomonadales	G	Glycosyl hydrolase 36 superfamily, catalytic domain	-	-	-	ko:K13688	-	-	-	-	ko00000,ko01000,ko01003	-	GH94,GT84	-	Glyco_hydro_36,Glyco_trans_2_3,Glyco_transf_36,Glycoamylase
HKD2_k127_39099_1	639030.JHVA01000001_gene2122	7.498e-57	210.0	COG1032@1|root,COG1032@2|Bacteria,3Y3GN@57723|Acidobacteria,2JI34@204432|Acidobacteriia	204432|Acidobacteriia	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
HKD2_k127_39099_0	926550.CLDAP_24600	4.699e-67	232.0	COG0664@1|root,COG0664@2|Bacteria,2G63K@200795|Chloroflexi	200795|Chloroflexi	T	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3910648_1	448385.sce5122	3.122e-99	334.0	COG1715@1|root,COG1715@2|Bacteria,1QXA7@1224|Proteobacteria,438GS@68525|delta/epsilon subdivisions,2X3RM@28221|Deltaproteobacteria,2YWXV@29|Myxococcales	28221|Deltaproteobacteria	V	HB1, ASXL, restriction endonuclease HTH domain	-	-	-	-	-	-	-	-	-	-	-	-	HARE-HTH,Mrr_cat
HKD2_k127_3910648_3	1238182.C882_2310	1.782e-15	87.0	COG0457@1|root,COG3914@1|root,COG0457@2|Bacteria,COG3914@2|Bacteria,1MVMG@1224|Proteobacteria,2TRVB@28211|Alphaproteobacteria,2JPYC@204441|Rhodospirillales	204441|Rhodospirillales	O	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_41,TPR_1,TPR_11,TPR_16,TPR_19,TPR_2,TPR_8
HKD2_k127_3910648_0	448385.sce2040	5.505e-123	405.0	COG0631@1|root,COG0631@2|Bacteria,1NCRX@1224|Proteobacteria,43ABC@68525|delta/epsilon subdivisions,2X2PV@28221|Deltaproteobacteria,2Z0FJ@29|Myxococcales	28221|Deltaproteobacteria	T	Serine/threonine phosphatases, family 2C, catalytic domain	-	-	3.1.3.16	ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C_2
HKD2_k127_3910648_2	1192034.CAP_7898	2.705e-35	138.0	COG1716@1|root,COG1716@2|Bacteria,1QH9U@1224|Proteobacteria,434RS@68525|delta/epsilon subdivisions,2WZ2V@28221|Deltaproteobacteria,2Z17M@29|Myxococcales	28221|Deltaproteobacteria	T	FHA domain	-	-	-	-	-	-	-	-	-	-	-	-	FHA
HKD2_k127_3911051_0	118166.JH976537_gene4024	4.614e-251	786.0	COG1452@1|root,COG1452@2|Bacteria,1G0TW@1117|Cyanobacteria,1H7RX@1150|Oscillatoriales	1117|Cyanobacteria	M	Mannosyl oligosaccharide glucosidase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_63
HKD2_k127_3911051_1	448385.sce4033	1.405e-68	254.0	2AJ10@1|root,319J4@2|Bacteria,1Q2X4@1224|Proteobacteria,438K5@68525|delta/epsilon subdivisions,2X3UQ@28221|Deltaproteobacteria,2YX5Z@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3912499_3	869210.Marky_1602	1.285e-12	79.0	COG1527@1|root,COG1527@2|Bacteria,1WIV8@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpC	-	-	ko:K02119	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	vATP-synt_AC39
HKD2_k127_3912499_4	290397.Adeh_1201	1.664e-06	60.0	COG1436@1|root,COG1436@2|Bacteria	2|Bacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpF	-	-	ko:K02122	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_F
HKD2_k127_3912499_0	290397.Adeh_1202	4.789e-167	548.0	COG1155@1|root,COG1155@2|Bacteria,1MWRR@1224|Proteobacteria,42NKK@68525|delta/epsilon subdivisions,2WIQQ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit	-	-	3.6.3.14,3.6.3.15	ko:K02117	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002,ko01000	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn
HKD2_k127_3912499_1	404589.Anae109_2563	1.07e-158	537.0	COG1156@1|root,COG1156@2|Bacteria,1R4RB@1224|Proteobacteria,42PJC@68525|delta/epsilon subdivisions,2WJB9@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit	-	-	-	ko:K02118	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N
HKD2_k127_3912499_2	290397.Adeh_1204	1.371e-15	85.0	COG1394@1|root,COG1394@2|Bacteria,1PA1A@1224|Proteobacteria,42VQ3@68525|delta/epsilon subdivisions,2WT1Q@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	-	-	-	ko:K02120	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_D
HKD2_k127_3913673_0	671143.DAMO_0982	1.311e-88	304.0	COG0535@1|root,COG0535@2|Bacteria,2NQVH@2323|unclassified Bacteria	2|Bacteria	S	Elongator protein 3, MiaB family, Radical SAM	pqqE	-	-	ko:K22226,ko:K22227	-	-	-	-	ko00000	-	-	-	Fer4_12,Radical_SAM,SPASM
HKD2_k127_3913673_2	1123368.AUIS01000008_gene2153	0.0004875	51.0	COG3945@1|root,COG3945@2|Bacteria,1N383@1224|Proteobacteria,1S89I@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Pfam Hemerythrin HHE	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
HKD2_k127_3913673_1	502025.Hoch_4101	2.238e-18	87.0	COG0664@1|root,COG0664@2|Bacteria,1QAZ0@1224|Proteobacteria,43E4R@68525|delta/epsilon subdivisions,2WZQH@28221|Deltaproteobacteria,2Z2IM@29|Myxococcales	28221|Deltaproteobacteria	K	Crp-like helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Crp_2,cNMP_binding
HKD2_k127_3913940_11	448385.sce5959	1.042e-52	189.0	COG0468@1|root,COG0468@2|Bacteria,1MU3C@1224|Proteobacteria,42M69@68525|delta/epsilon subdivisions,2WIYC@28221|Deltaproteobacteria,2YTSX@29|Myxococcales	28221|Deltaproteobacteria	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage	recA	-	-	ko:K03553	ko03440,map03440	M00729	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	RecA
HKD2_k127_3913940_5	448385.sce7256	3.533e-135	432.0	COG0639@1|root,COG0639@2|Bacteria,1MUV1@1224|Proteobacteria,42RNB@68525|delta/epsilon subdivisions,2WQ81@28221|Deltaproteobacteria,2YTTJ@29|Myxococcales	28221|Deltaproteobacteria	T	Diadenosine tetraphosphatase and related serine threonine protein phosphatases	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos_2
HKD2_k127_3913940_13	448385.sce7255	9.044e-29	123.0	2BFUE@1|root,329PK@2|Bacteria,1QAVH@1224|Proteobacteria,435BN@68525|delta/epsilon subdivisions,2WZP4@28221|Deltaproteobacteria,2Z2G3@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3913940_7	930171.Asphe3_20930	7.545e-105	353.0	COG1064@1|root,COG1064@2|Bacteria,2GNVQ@201174|Actinobacteria,1W8QY@1268|Micrococcaceae	201174|Actinobacteria	S	alcohol dehydrogenase	adhA	-	1.1.1.1	ko:K13953	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
HKD2_k127_3913940_2	981369.JQMJ01000004_gene4964	9.632e-206	651.0	COG2197@1|root,COG2206@1|root,COG2197@2|Bacteria,COG2206@2|Bacteria,2GJS8@201174|Actinobacteria,2NKD9@228398|Streptacidiphilus	201174|Actinobacteria	KT	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	GerE,HD_5
HKD2_k127_3913940_12	1306174.JODP01000005_gene1322	3.445e-34	140.0	COG0500@1|root,COG2226@2|Bacteria,2H9G5@201174|Actinobacteria	201174|Actinobacteria	Q	Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
HKD2_k127_3913940_4	379066.GAU_2382	9.513e-140	474.0	COG1013@1|root,COG1013@2|Bacteria,1ZSWT@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
HKD2_k127_3913940_1	1379270.AUXF01000003_gene3544	3.117e-256	806.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,1ZSVF@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR,POR_N
HKD2_k127_3913940_0	1280944.HY17_08395	5.86e-274	854.0	COG0493@1|root,COG1143@1|root,COG0493@2|Bacteria,COG1143@2|Bacteria,1MU2H@1224|Proteobacteria,2TQK5@28211|Alphaproteobacteria,43ZFF@69657|Hyphomonadaceae	28211|Alphaproteobacteria	C	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	MA20_01050	-	1.17.1.10	ko:K15022	ko00680,ko00720,ko01120,ko01200,map00680,map00720,map01120,map01200	M00377	R00134	RC02796	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4_20,Fer4_7,NADH_4Fe-4S,Pyr_redox_2,Pyr_redox_3
HKD2_k127_3913940_14	105559.Nwat_3082	1.286e-28	126.0	COG3247@1|root,COG3247@2|Bacteria,1RFIH@1224|Proteobacteria,1S6XJ@1236|Gammaproteobacteria,1WYQ5@135613|Chromatiales	135613|Chromatiales	S	Short repeat of unknown function (DUF308)	-	-	-	-	-	-	-	-	-	-	-	-	DUF308
HKD2_k127_3913940_9	1449058.JQKT01000009_gene90	3.413e-71	248.0	COG1028@1|root,COG1028@2|Bacteria,2GJGM@201174|Actinobacteria,4FMPC@85023|Microbacteriaceae	201174|Actinobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HKD2_k127_3913940_3	290397.Adeh_2970	2.206e-141	470.0	COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,42MAR@68525|delta/epsilon subdivisions,2WJEU@28221|Deltaproteobacteria,2YWC8@29|Myxococcales	28221|Deltaproteobacteria	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HKD2_k127_3913940_8	1242864.D187_001641	4.5e-83	301.0	COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,42P96@68525|delta/epsilon subdivisions,2WMVB@28221|Deltaproteobacteria,2YUCK@29|Myxococcales	28221|Deltaproteobacteria	P	Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD2_k127_3913940_6	290397.Adeh_2972	7.318e-106	361.0	COG0845@1|root,COG0845@2|Bacteria,1MU8D@1224|Proteobacteria,42NVA@68525|delta/epsilon subdivisions,2WMQK@28221|Deltaproteobacteria,2YWS4@29|Myxococcales	28221|Deltaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	HlyD_D23
HKD2_k127_3913940_10	1298593.TOL_1965	2.526e-54	198.0	COG4221@1|root,COG4221@2|Bacteria,1R2U2@1224|Proteobacteria,1T5XP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HKD2_k127_3919220_1	1192034.CAP_1706	6.768e-39	151.0	COG2064@1|root,COG2064@2|Bacteria,1MWAZ@1224|Proteobacteria,42SJ0@68525|delta/epsilon subdivisions,2WP1Z@28221|Deltaproteobacteria,2YVFE@29|Myxococcales	28221|Deltaproteobacteria	NU	Type II secretion system (T2SS), protein F	-	-	-	ko:K12511	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
HKD2_k127_3919220_0	1192034.CAP_1707	1.773e-83	289.0	COG4965@1|root,COG4965@2|Bacteria,1MYNG@1224|Proteobacteria,42UK9@68525|delta/epsilon subdivisions,2WQT2@28221|Deltaproteobacteria,2YVV9@29|Myxococcales	28221|Deltaproteobacteria	U	Type II secretion system (T2SS), protein F	-	-	-	ko:K12510	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
HKD2_k127_3919220_2	1192034.CAP_1708	1.738e-33	130.0	COG4962@1|root,COG4962@2|Bacteria,1R7EN@1224|Proteobacteria,42NAK@68525|delta/epsilon subdivisions,2WIYX@28221|Deltaproteobacteria,2YTSI@29|Myxococcales	28221|Deltaproteobacteria	TU	Type II IV secretion system protein	-	-	-	ko:K02283,ko:K03609	-	-	-	-	ko00000,ko02035,ko02044,ko03036,ko04812	-	-	-	CbiA,FHA,T2SSE
HKD2_k127_3919760_1	502025.Hoch_4100	2.141e-73	254.0	COG1232@1|root,COG1232@2|Bacteria,1MX35@1224|Proteobacteria,42NE7@68525|delta/epsilon subdivisions,2WJ77@28221|Deltaproteobacteria,2Z35P@29|Myxococcales	28221|Deltaproteobacteria	H	Flavin containing amine oxidoreductase	-	-	5.4.99.9	ko:K01854	ko00052,ko00520,map00052,map00520	-	R00505,R09009	RC00317,RC02396	ko00000,ko00001,ko01000	-	-	-	Amino_oxidase,NAD_binding_8
HKD2_k127_3919760_2	1192034.CAP_1591	2.44e-14	78.0	2BU8D@1|root,32PHV@2|Bacteria,1NANB@1224|Proteobacteria,433N8@68525|delta/epsilon subdivisions,2WXKZ@28221|Deltaproteobacteria,2YW2P@29|Myxococcales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF4920)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4920
HKD2_k127_3919760_0	391625.PPSIR1_13810	9.373e-74	260.0	COG0604@1|root,COG0604@2|Bacteria,1MWRK@1224|Proteobacteria	1224|Proteobacteria	C	COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases	MA20_32380	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
HKD2_k127_3924441_8	1463909.KL585956_gene4054	6.122e-11	73.0	COG2172@1|root,COG2172@2|Bacteria,2IKM9@201174|Actinobacteria	201174|Actinobacteria	T	anti-sigma regulatory factor	rsbT	-	2.7.11.1	ko:K17752	-	-	-	-	ko00000,ko01000,ko01001,ko03021	-	-	-	HATPase_c,HATPase_c_2,Sigma70_r2
HKD2_k127_3924441_4	926566.Terro_0168	1.061e-34	140.0	COG2172@1|root,COG2172@2|Bacteria,3Y4Y8@57723|Acidobacteria,2JJTJ@204432|Acidobacteriia	204432|Acidobacteriia	T	Histidine kinase-like ATPase domain	-	-	2.7.11.1	ko:K17752	-	-	-	-	ko00000,ko01000,ko01001,ko03021	-	-	-	HATPase_c
HKD2_k127_3924441_6	765914.ThisiDRAFT_0279	1.075e-25	119.0	COG1366@1|root,COG1366@2|Bacteria,1RJM8@1224|Proteobacteria,1S5C5@1236|Gammaproteobacteria,1WYB1@135613|Chromatiales	135613|Chromatiales	T	transporter antisigma-factor antagonist STAS	-	-	-	ko:K17762	-	-	-	-	ko00000,ko03021	-	-	-	STAS
HKD2_k127_3924441_2	448385.sce4091	8.447e-81	282.0	COG1366@1|root,COG1366@2|Bacteria,1MVPW@1224|Proteobacteria	1224|Proteobacteria	T	Anti-anti-sigma regulatory factor (Antagonist of anti-sigma factor)	-	-	-	ko:K17763	-	-	-	-	ko00000,ko03021	-	-	-	PAS_4,Protoglobin,STAS
HKD2_k127_3924441_3	1380391.JIAS01000013_gene3693	2.292e-40	164.0	COG4191@1|root,COG4191@2|Bacteria,1NC2U@1224|Proteobacteria,2U484@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,MASE3,Response_reg
HKD2_k127_3924441_1	525904.Tter_0222	2.125e-91	313.0	COG0517@1|root,COG1994@1|root,COG0517@2|Bacteria,COG1994@2|Bacteria,2NPE1@2323|unclassified Bacteria	2|Bacteria	S	Peptidase family M50	rip3	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	ko:K06212,ko:K06402	-	-	-	-	ko00000,ko01000,ko01002,ko02000	1.A.16.1.1,1.A.16.1.3	-	-	CBS,Form_Nir_trans,Peptidase_M50
HKD2_k127_3924441_7	404589.Anae109_4087	2.145e-25	113.0	COG0589@1|root,COG0589@2|Bacteria,1RA7K@1224|Proteobacteria,42V2P@68525|delta/epsilon subdivisions,2WRFB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Universal stress protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD2_k127_3924441_0	1254432.SCE1572_35745	4.31e-215	679.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2YTW0@29|Myxococcales	28221|Deltaproteobacteria	T	response regulator	-	-	-	ko:K02481,ko:K07713	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD2_k127_3924441_9	1192034.CAP_6437	1.99e-09	63.0	COG0346@1|root,COG0346@2|Bacteria,1PY3J@1224|Proteobacteria,4352G@68525|delta/epsilon subdivisions,2WZDE@28221|Deltaproteobacteria,2Z1W6@29|Myxococcales	28221|Deltaproteobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HKD2_k127_3924441_5	448385.sce5295	4.061e-33	139.0	COG1193@1|root,COG1193@2|Bacteria,1R0CV@1224|Proteobacteria	2|Bacteria	L	DNA mismatch repair protein	mutS2	-	-	ko:K07456	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_V,Smr
HKD2_k127_393469_4	1191460.F959_01915	0.0001209	45.0	COG4221@1|root,COG4221@2|Bacteria,1R2U2@1224|Proteobacteria,1T5XP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HKD2_k127_393469_0	1192034.CAP_3786	2.296e-133	434.0	COG0152@1|root,COG0152@2|Bacteria,1MUR9@1224|Proteobacteria,42M8A@68525|delta/epsilon subdivisions,2WJY0@28221|Deltaproteobacteria,2YUIU@29|Myxococcales	28221|Deltaproteobacteria	F	Belongs to the SAICAR synthetase family	purC	GO:0003674,GO:0003824,GO:0004639,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.2.6	ko:K01923	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04591	RC00064,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	SAICAR_synt
HKD2_k127_393469_3	448385.sce1715	2.221e-68	247.0	COG1994@1|root,COG1994@2|Bacteria,1QZHR@1224|Proteobacteria,43CIT@68525|delta/epsilon subdivisions,2X7T2@28221|Deltaproteobacteria,2Z3HE@29|Myxococcales	28221|Deltaproteobacteria	S	Peptidase family M50	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M50
HKD2_k127_393469_5	391008.Smal_1878	0.0009146	51.0	COG1317@1|root,COG1317@2|Bacteria,1N5X8@1224|Proteobacteria,1SXJN@1236|Gammaproteobacteria,1X6BH@135614|Xanthomonadales	135614|Xanthomonadales	N	flagellar assembly protein FliH	fliH	-	-	ko:K02411	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	FliH
HKD2_k127_393469_1	1192034.CAP_0723	6.225e-96	331.0	COG0491@1|root,COG0491@2|Bacteria,1MVC3@1224|Proteobacteria,430H1@68525|delta/epsilon subdivisions,2WVZX@28221|Deltaproteobacteria,2YUWZ@29|Myxococcales	28221|Deltaproteobacteria	L	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B,NUDIX
HKD2_k127_393469_2	1254432.SCE1572_41455	2.855e-90	301.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,42MSR@68525|delta/epsilon subdivisions,2WIXG@28221|Deltaproteobacteria,2YUF5@29|Myxococcales	28221|Deltaproteobacteria	I	Belongs to the thiolase family	bamN	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
HKD2_k127_3935085_0	1254432.SCE1572_42865	1.473e-111	364.0	COG0714@1|root,COG0714@2|Bacteria,1MUFN@1224|Proteobacteria,42NCX@68525|delta/epsilon subdivisions,2WJUZ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	ATPase associated with various cellular activities	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
HKD2_k127_3942511_0	1458275.AZ34_16285	2.804e-125	405.0	COG0618@1|root,COG0618@2|Bacteria,1MX0B@1224|Proteobacteria,2WI70@28216|Betaproteobacteria,4AK4E@80864|Comamonadaceae	28216|Betaproteobacteria	S	3'(2'),5'-bisphosphate nucleotidase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3942511_2	1242864.D187_004416	2.291e-31	128.0	COG0278@1|root,COG0278@2|Bacteria,1RKVH@1224|Proteobacteria,43CUY@68525|delta/epsilon subdivisions,2X82Q@28221|Deltaproteobacteria,2YVJZ@29|Myxococcales	28221|Deltaproteobacteria	O	Glutaredoxin	-	-	-	-	-	-	-	-	-	-	-	-	Glutaredoxin
HKD2_k127_3942511_1	706587.Desti_1404	2.493e-124	422.0	COG0784@1|root,COG2202@1|root,COG4191@1|root,COG5000@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG4191@2|Bacteria,COG5000@2|Bacteria,1RCM9@1224|Proteobacteria,42M1R@68525|delta/epsilon subdivisions,2WK3J@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg,SBP_bac_3
HKD2_k127_3948155_6	1380390.JIAT01000014_gene6164	1.034e-51	187.0	COG0067@1|root,COG0069@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,2GN09@201174|Actinobacteria,4CP7B@84995|Rubrobacteria	84995|Rubrobacteria	E	GXGXG motif	-	-	1.4.1.13,1.4.1.14	ko:K00265	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
HKD2_k127_3948155_0	1254432.SCE1572_30765	4.151e-163	534.0	COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,42MGY@68525|delta/epsilon subdivisions,2WJZJ@28221|Deltaproteobacteria,2Z2XA@29|Myxococcales	28221|Deltaproteobacteria	C	Glutamate synthase	gltD	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4_20,Pyr_redox_2
HKD2_k127_3948155_10	253839.SSNG_07467	1.203e-05	57.0	2B7WC@1|root,3213B@2|Bacteria,2H50F@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3948155_9	314230.DSM3645_14245	8.334e-28	116.0	2BZBR@1|root,32YH6@2|Bacteria,2J41E@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3948155_4	1192034.CAP_4410	1.106e-63	230.0	COG5031@1|root,COG5031@2|Bacteria,1NF8V@1224|Proteobacteria,434IK@68525|delta/epsilon subdivisions,2X8WT@28221|Deltaproteobacteria,2Z0RP@29|Myxococcales	28221|Deltaproteobacteria	H	Coenzyme Q (ubiquinone) biosynthesis protein Coq4	-	-	-	-	-	-	-	-	-	-	-	-	Coq4
HKD2_k127_3948155_8	402881.Plav_1640	8.738e-29	124.0	COG1309@1|root,COG1309@2|Bacteria,1NB4W@1224|Proteobacteria,2UIGM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
HKD2_k127_3948155_7	448385.sce2344	9.863e-33	139.0	COG1186@1|root,COG1186@2|Bacteria,1RH75@1224|Proteobacteria,42UF8@68525|delta/epsilon subdivisions,2WR6W@28221|Deltaproteobacteria,2Z1VX@29|Myxococcales	28221|Deltaproteobacteria	J	RF-1 domain	-	-	-	ko:K15034	-	-	-	-	ko00000,ko03012	-	-	-	RF-1
HKD2_k127_3948155_3	1254432.SCE1572_09580	2e-96	337.0	COG2017@1|root,COG2017@2|Bacteria,1MVR4@1224|Proteobacteria,42USW@68525|delta/epsilon subdivisions,2WSX3@28221|Deltaproteobacteria,2YYMY@29|Myxococcales	28221|Deltaproteobacteria	G	Aldose 1-epimerase	-	-	-	-	-	-	-	-	-	-	-	-	Aldose_epim
HKD2_k127_3948155_2	448385.sce3822	3.808e-105	370.0	COG0540@1|root,COG0540@2|Bacteria,1MWAB@1224|Proteobacteria,42NMR@68525|delta/epsilon subdivisions,2WJQR@28221|Deltaproteobacteria,2YU78@29|Myxococcales	28221|Deltaproteobacteria	F	Belongs to the ATCase OTCase family	pyrB	GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
HKD2_k127_3948155_1	502025.Hoch_3948	3.718e-153	501.0	COG0044@1|root,COG0044@2|Bacteria,1MVXY@1224|Proteobacteria,42MJ9@68525|delta/epsilon subdivisions,2WJH8@28221|Deltaproteobacteria,2YU2Z@29|Myxococcales	28221|Deltaproteobacteria	F	Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily	pyrC	GO:0003674,GO:0003824,GO:0004038,GO:0004151,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006144,GO:0006145,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016787,GO:0016810,GO:0016812,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046113,GO:0046390,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
HKD2_k127_3948155_5	1173020.Cha6605_6116	1.711e-55	201.0	COG0406@1|root,COG0406@2|Bacteria,1G08X@1117|Cyanobacteria	1117|Cyanobacteria	G	PFAM Phosphoglycerate mutase	-	-	3.1.3.73	ko:K02226	ko00860,ko01100,map00860,map01100	M00122	R04594,R11173	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	His_Phos_1
HKD2_k127_3949325_0	1192034.CAP_2498	8.33e-316	980.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,42NHZ@68525|delta/epsilon subdivisions,2WJ2H@28221|Deltaproteobacteria,2YX1T@29|Myxococcales	28221|Deltaproteobacteria	H	Methionine synthase	metH	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
HKD2_k127_3950573_8	351607.Acel_1699	3.427e-54	190.0	COG0535@1|root,COG0535@2|Bacteria,2HTDD@201174|Actinobacteria,4ES4M@85013|Frankiales	201174|Actinobacteria	F	PFAM Radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF3463,Fer4_14,Radical_SAM
HKD2_k127_3950573_7	1254432.SCE1572_25530	3.827e-63	233.0	COG0142@1|root,COG0142@2|Bacteria,1PIT3@1224|Proteobacteria,4354P@68525|delta/epsilon subdivisions,2X95E@28221|Deltaproteobacteria,2Z21G@29|Myxococcales	28221|Deltaproteobacteria	H	Polyprenyl synthetase	-	-	2.5.1.1,2.5.1.10,2.5.1.29	ko:K13787	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00365	R01658,R02003,R02061	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
HKD2_k127_3950573_6	1254432.SCE1572_25535	5.828e-64	237.0	COG1577@1|root,COG1577@2|Bacteria,1NBQM@1224|Proteobacteria,43C2T@68525|delta/epsilon subdivisions,2X7DD@28221|Deltaproteobacteria,2YVJ4@29|Myxococcales	28221|Deltaproteobacteria	I	mevalonate kinase	mvk	-	2.7.1.36	ko:K00869	ko00900,ko01100,ko01110,ko01130,ko04146,map00900,map01100,map01110,map01130,map04146	M00095	R02245	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
HKD2_k127_3950573_3	246197.MXAN_5020	8.215e-140	456.0	COG1257@1|root,COG1257@2|Bacteria,1MXVE@1224|Proteobacteria,42R5Q@68525|delta/epsilon subdivisions,2WN6K@28221|Deltaproteobacteria,2YTT9@29|Myxococcales	28221|Deltaproteobacteria	C	Belongs to the HMG-CoA reductase family	mvaA	-	1.1.1.88	ko:K00054	ko00900,ko01110,ko01130,map00900,map01110,map01130	-	R02081	RC00004,RC00644	ko00000,ko00001,ko01000	-	-	-	HMG-CoA_red
HKD2_k127_3950573_4	926550.CLDAP_37850	3.632e-93	338.0	COG0665@1|root,COG0665@2|Bacteria,2G6XM@200795|Chloroflexi	200795|Chloroflexi	E	FAD dependent oxidoreductase	-	-	1.5.3.1	ko:K00301	ko00260,ko01100,map00260,map01100	-	R00610	RC00060,RC00557	ko00000,ko00001,ko01000	-	-	-	DAO
HKD2_k127_3950573_5	448385.sce2291	1.097e-75	271.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,42MVV@68525|delta/epsilon subdivisions,2X4JB@28221|Deltaproteobacteria,2YZ4I@29|Myxococcales	28221|Deltaproteobacteria	KLT	Family membership	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HKD2_k127_3950573_1	378806.STAUR_1028	1.271e-153	496.0	COG2301@1|root,COG2301@2|Bacteria,1R7U2@1224|Proteobacteria,437FH@68525|delta/epsilon subdivisions,2X2N4@28221|Deltaproteobacteria,2YTXN@29|Myxococcales	28221|Deltaproteobacteria	G	Belongs to the HpcH HpaI aldolase family	-	-	-	-	-	-	-	-	-	-	-	-	HpcH_HpaI
HKD2_k127_3950573_11	483219.LILAB_05825	5.013e-16	90.0	2C5BM@1|root,32RFE@2|Bacteria,1Q9I2@1224|Proteobacteria,43E05@68525|delta/epsilon subdivisions,2WZBP@28221|Deltaproteobacteria,2Z1SM@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3950573_9	192875.XP_004345681.1	1.352e-27	126.0	COG2351@1|root,KOG3006@2759|Eukaryota,3A8EU@33154|Opisthokonta	33154|Opisthokonta	I	hydroxyisourate hydrolase activity	urah	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0006139,GO:0006144,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009112,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0016812,GO:0033971,GO:0034641,GO:0042579,GO:0042802,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:1901360,GO:1901564	3.5.2.17	ko:K05689,ko:K07127	ko00230,ko01100,ko01120,ko04015,ko04371,ko04390,ko04514,ko04520,ko05100,ko05130,ko05200,ko05213,ko05216,ko05218,ko05219,ko05226,map00230,map01100,map01120,map04015,map04371,map04390,map04514,map04520,map05100,map05130,map05200,map05213,map05216,map05218,map05219,map05226	M00546	R06601	RC03393	ko00000,ko00001,ko00002,ko01000,ko02000,ko03036,ko04090,ko04516	9.B.35.1.2,9.B.35.2	-	-	Transthyretin
HKD2_k127_3950573_10	448385.sce2383	1.13e-21	108.0	2AQA0@1|root,31FFY@2|Bacteria,1QA7N@1224|Proteobacteria,434VZ@68525|delta/epsilon subdivisions,2WZ72@28221|Deltaproteobacteria,2Z1GK@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3950573_2	1254432.SCE1572_35005	2.674e-143	471.0	COG3195@1|root,COG4266@1|root,COG3195@2|Bacteria,COG4266@2|Bacteria,1MXJK@1224|Proteobacteria,42YE0@68525|delta/epsilon subdivisions,2X30N@28221|Deltaproteobacteria,2YTWS@29|Myxococcales	28221|Deltaproteobacteria	F	Belongs to the allantoicase family	alc	-	3.5.3.4	ko:K01477	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R02422	RC00379,RC00712	ko00000,ko00001,ko00002,ko01000	-	-	-	Allantoicase,OHCU_decarbox
HKD2_k127_3950573_0	1254432.SCE1572_35000	3.126e-173	555.0	COG0044@1|root,COG0044@2|Bacteria,1MW10@1224|Proteobacteria,42RF2@68525|delta/epsilon subdivisions,2WP05@28221|Deltaproteobacteria,2YWCM@29|Myxococcales	28221|Deltaproteobacteria	F	Amidohydrolase family	allB	-	3.5.2.5	ko:K01466	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R02425	RC00680	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
HKD2_k127_3950573_12	1380367.JIBC01000002_gene2553	1.139e-11	77.0	COG1520@1|root,COG1520@2|Bacteria,1MXIJ@1224|Proteobacteria,2TUAD@28211|Alphaproteobacteria,3ZVCM@60136|Sulfitobacter	28211|Alphaproteobacteria	S	PQQ-like domain	bamB	-	-	ko:K17713	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	PQQ_2,PQQ_3
HKD2_k127_3956112_5	1340493.JNIF01000004_gene172	3.996e-10	74.0	COG1073@1|root,COG1073@2|Bacteria	2|Bacteria	S	thiolester hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
HKD2_k127_3956112_2	1382359.JIAL01000001_gene2991	1.725e-80	282.0	COG0846@1|root,COG0846@2|Bacteria,3Y4T9@57723|Acidobacteria	57723|Acidobacteria	K	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form	cobB	-	-	ko:K12410	-	-	-	-	ko00000,ko01000	-	-	-	SIR2
HKD2_k127_3956112_4	1144275.COCOR_07005	1.775e-42	171.0	COG1073@1|root,COG1073@2|Bacteria,1RIWI@1224|Proteobacteria,42TGK@68525|delta/epsilon subdivisions,2WRH2@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	alpha beta	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Abhydrolase_6,Hydrolase_4
HKD2_k127_3956112_0	448385.sce7645	4.909e-146	479.0	COG0737@1|root,COG0737@2|Bacteria,1ND4P@1224|Proteobacteria,42W6F@68525|delta/epsilon subdivisions,2WRWE@28221|Deltaproteobacteria,2Z2VY@29|Myxococcales	28221|Deltaproteobacteria	C	Cytochrome c554 and c-prime	-	-	3.1.3.6,3.1.4.16	ko:K01119	ko00230,ko00240,map00230,map00240	-	R01562,R01877,R02148,R02370,R03537,R03538,R03929,R05135	RC00078,RC00296	ko00000,ko00001,ko01000	-	-	-	Cytochrome_C554
HKD2_k127_3956112_3	502025.Hoch_5887	4.852e-78	285.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,42RC9@68525|delta/epsilon subdivisions,2WN5U@28221|Deltaproteobacteria,2YWJ8@29|Myxococcales	28221|Deltaproteobacteria	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	DUF4388,PEGA,Pkinase
HKD2_k127_3956112_1	448385.sce7646	2.977e-100	336.0	COG1463@1|root,COG1463@2|Bacteria,1RFFS@1224|Proteobacteria,42P4P@68525|delta/epsilon subdivisions,2WNNQ@28221|Deltaproteobacteria,2YUZI@29|Myxococcales	28221|Deltaproteobacteria	Q	MlaD protein	-	-	-	ko:K02067	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaD
HKD2_k127_3956976_1	1192034.CAP_1433	9.904e-134	433.0	COG1505@1|root,COG1505@2|Bacteria,1NZ7N@1224|Proteobacteria,42NR5@68525|delta/epsilon subdivisions,2WMMK@28221|Deltaproteobacteria,2YU26@29|Myxococcales	28221|Deltaproteobacteria	E	Prolyl oligopeptidase, N-terminal beta-propeller domain	pep	-	3.4.21.26	ko:K01322	ko04614,map04614	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S9,Peptidase_S9_N
HKD2_k127_3956976_0	1192034.CAP_1677	3.842e-229	717.0	COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,42N8U@68525|delta/epsilon subdivisions,2WJAN@28221|Deltaproteobacteria,2YYIW@29|Myxococcales	28221|Deltaproteobacteria	H	Belongs to the citrate synthase family	gltA	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
HKD2_k127_3956976_2	1192034.CAP_3207	1.34e-17	84.0	COG3507@1|root,COG3507@2|Bacteria,1R5F2@1224|Proteobacteria,43E6V@68525|delta/epsilon subdivisions,2X7I1@28221|Deltaproteobacteria,2YZ3Q@29|Myxococcales	28221|Deltaproteobacteria	G	Glycosyl hydrolases family 43	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_43
HKD2_k127_3956976_3	378806.STAUR_2025	1.359e-17	85.0	COG3507@1|root,COG3507@2|Bacteria,1R5F2@1224|Proteobacteria,43E6V@68525|delta/epsilon subdivisions,2X7I1@28221|Deltaproteobacteria,2YZ3Q@29|Myxococcales	28221|Deltaproteobacteria	G	Glycosyl hydrolases family 43	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_43
HKD2_k127_3958304_2	1121861.KB899941_gene3869	4.095e-08	58.0	COG3605@1|root,COG3605@2|Bacteria,1QTTV@1224|Proteobacteria,2TR3Z@28211|Alphaproteobacteria,2JQ06@204441|Rhodospirillales	204441|Rhodospirillales	T	Belongs to the PEP-utilizing enzyme family	ptsP	-	2.7.3.9	ko:K08484	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	-	-	-	GAF_2,PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C
HKD2_k127_3958304_0	1380390.JIAT01000010_gene4081	1.509e-101	346.0	COG2267@1|root,COG2267@2|Bacteria,2GJ78@201174|Actinobacteria,4CSBE@84995|Rubrobacteria	84995|Rubrobacteria	I	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
HKD2_k127_3958304_1	1538295.JY96_21010	9.095e-51	187.0	COG1814@1|root,COG1814@2|Bacteria,1MUZE@1224|Proteobacteria,2VJ27@28216|Betaproteobacteria,1KKQ4@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	VIT family	-	-	-	-	-	-	-	-	-	-	-	-	VIT1
HKD2_k127_3958467_0	518766.Rmar_1948	1.276e-137	451.0	COG3033@1|root,COG3033@2|Bacteria,4NEP4@976|Bacteroidetes,1FJ19@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	E	Beta-eliminating lyase	tnaA	-	4.1.99.1	ko:K01667	ko00380,map00380	-	R00673	RC00209,RC00355	ko00000,ko00001,ko01000	-	-	-	Beta_elim_lyase
HKD2_k127_3958467_3	215803.DB30_3835	3.639e-37	144.0	28QQ1@1|root,2ZD5J@2|Bacteria,1QPY8@1224|Proteobacteria,439MX@68525|delta/epsilon subdivisions,2X4Z5@28221|Deltaproteobacteria,2YZVK@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3958467_1	502025.Hoch_5018	4.879e-127	420.0	COG0451@1|root,COG0451@2|Bacteria,1N8PG@1224|Proteobacteria,42TCH@68525|delta/epsilon subdivisions,2WPEI@28221|Deltaproteobacteria,2YUC8@29|Myxococcales	28221|Deltaproteobacteria	GM	RmlD substrate binding domain	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
HKD2_k127_3958467_2	448385.sce6495	1.974e-56	199.0	COG0204@1|root,COG0204@2|Bacteria,1R9IG@1224|Proteobacteria,42T29@68525|delta/epsilon subdivisions,2WPJ8@28221|Deltaproteobacteria,2YU1X@29|Myxococcales	28221|Deltaproteobacteria	I	Phosphate acyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Acyltransferase
HKD2_k127_3959021_1	1254432.SCE1572_05830	4.514e-62	226.0	COG1470@1|root,COG1470@2|Bacteria,1QZIJ@1224|Proteobacteria,43CK1@68525|delta/epsilon subdivisions,2X7UG@28221|Deltaproteobacteria,2YY6W@29|Myxococcales	28221|Deltaproteobacteria	S	PEGA domain	-	-	-	-	-	-	-	-	-	-	-	-	PEGA
HKD2_k127_3959021_0	1192034.CAP_0783	2.788e-76	273.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,4346X@68525|delta/epsilon subdivisions,2XA3R@28221|Deltaproteobacteria,2YXWE@29|Myxococcales	28221|Deltaproteobacteria	KLT	Protein kinase domain	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
HKD2_k127_3959021_2	1192034.CAP_0782	6.16e-55	199.0	COG1595@1|root,COG1595@2|Bacteria,1Q6A3@1224|Proteobacteria,439KI@68525|delta/epsilon subdivisions,2X4XA@28221|Deltaproteobacteria,2YZSJ@29|Myxococcales	28221|Deltaproteobacteria	K	Sigma-70 region 2	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2
HKD2_k127_3962274_1	1151292.QEW_0834	2.725e-41	155.0	COG0441@1|root,COG0441@2|Bacteria,1TP78@1239|Firmicutes,248CH@186801|Clostridia,25QSG@186804|Peptostreptococcaceae	186801|Clostridia	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	-	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD
HKD2_k127_3962274_0	189753.AXAS01000020_gene1754	5.474e-101	347.0	COG2114@1|root,COG2114@2|Bacteria,1MWHK@1224|Proteobacteria,2TR2J@28211|Alphaproteobacteria,3JQNR@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc
HKD2_k127_3976918_4	552811.Dehly_1438	1.288e-33	134.0	2DNS7@1|root,32YWC@2|Bacteria	2|Bacteria	S	S23 ribosomal protein	-	-	-	-	-	-	-	-	-	-	-	-	23S_rRNA_IVP
HKD2_k127_3976918_2	1254432.SCE1572_40870	1.747e-102	340.0	COG0631@1|root,COG0631@2|Bacteria,1R7UF@1224|Proteobacteria,439RM@68525|delta/epsilon subdivisions,2X54F@28221|Deltaproteobacteria,2Z03P@29|Myxococcales	28221|Deltaproteobacteria	T	Serine/threonine phosphatases, family 2C, catalytic domain	-	-	3.1.3.16	ko:K01090,ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C_2
HKD2_k127_3976918_1	338963.Pcar_1237	2.703e-152	492.0	COG0334@1|root,COG0334@2|Bacteria,1MUMF@1224|Proteobacteria,42NK7@68525|delta/epsilon subdivisions,2WKTV@28221|Deltaproteobacteria,43RYC@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain	-	-	1.4.1.3	ko:K00261	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
HKD2_k127_3976918_3	1121920.AUAU01000018_gene1785	2.373e-39	159.0	COG0671@1|root,COG0671@2|Bacteria,3Y90S@57723|Acidobacteria	57723|Acidobacteria	I	PAP2 superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PAP2_3
HKD2_k127_3976918_5	404589.Anae109_4087	2.827e-18	95.0	COG0589@1|root,COG0589@2|Bacteria,1RA7K@1224|Proteobacteria,42V2P@68525|delta/epsilon subdivisions,2WRFB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Universal stress protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD2_k127_3976918_6	1085623.GNIT_1981	2.165e-17	91.0	COG0517@1|root,COG0517@2|Bacteria,1QTVM@1224|Proteobacteria,1SFWU@1236|Gammaproteobacteria,46BCN@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
HKD2_k127_3976918_0	1278073.MYSTI_02849	1.16e-156	516.0	COG4789@1|root,COG4789@2|Bacteria,1R346@1224|Proteobacteria,43DIZ@68525|delta/epsilon subdivisions,2X8Q9@28221|Deltaproteobacteria	28221|Deltaproteobacteria	U	Type III secretion protein	-	-	-	ko:K03230	ko03070,map03070	M00332,M00542,M00660	-	-	ko00000,ko00001,ko00002,ko02044	3.A.6.1,3.A.6.3	-	-	FHIPEP
HKD2_k127_3978_0	378806.STAUR_2080	4.256e-159	510.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,42M0D@68525|delta/epsilon subdivisions,2WK8T@28221|Deltaproteobacteria,2YY3N@29|Myxococcales	28221|Deltaproteobacteria	I	Thiolase, C-terminal domain	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
HKD2_k127_3978_3	1192034.CAP_5697	2.305e-05	53.0	COG2515@1|root,COG2515@2|Bacteria,1MVYF@1224|Proteobacteria,42PWI@68525|delta/epsilon subdivisions,2WPU4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Pyridoxal-phosphate dependent enzyme	-	-	4.4.1.15	ko:K05396	ko00270,map00270	-	R01874	RC00382	ko00000,ko00001,ko01000	-	-	-	PALP
HKD2_k127_3978_1	1128421.JAGA01000003_gene3258	1.242e-60	233.0	COG2303@1|root,COG2303@2|Bacteria,2NRUE@2323|unclassified Bacteria	2|Bacteria	E	GMC oxidoreductase	-	-	1.1.3.6	ko:K03333	ko00984,ko01120,map00984,map01120	-	R01459	RC00146	ko00000,ko00001,ko01000	-	-	-	GMC_oxred_C,GMC_oxred_N,Gluconate_2-dh3
HKD2_k127_3978_2	1549858.MC45_00975	7.043e-08	56.0	COG3616@1|root,COG3616@2|Bacteria	2|Bacteria	E	Alanine racemase, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Ala_racemase_N
HKD2_k127_3983573_0	1192034.CAP_0942	2.137e-160	524.0	COG1073@1|root,COG1073@2|Bacteria,1QRTY@1224|Proteobacteria,433U7@68525|delta/epsilon subdivisions,2X3GS@28221|Deltaproteobacteria,2YW15@29|Myxococcales	28221|Deltaproteobacteria	S	alpha beta	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3983573_3	448385.sce2189	4.287e-35	148.0	COG3291@1|root,COG4786@1|root,COG3291@2|Bacteria,COG4786@2|Bacteria	2|Bacteria	N	Flagellar basal body rod	flgK	-	3.2.1.14	ko:K01183,ko:K02396	ko00520,ko01100,ko02040,map00520,map01100,map02040	-	R01206,R02334	RC00467	ko00000,ko00001,ko01000,ko02035	-	GH18	-	DUF2950,Flg_bb_rod,Flg_bbr_C
HKD2_k127_3983573_2	290397.Adeh_1745	2.812e-36	143.0	COG0716@1|root,COG0716@2|Bacteria,1NANK@1224|Proteobacteria	1224|Proteobacteria	C	FMN binding	-	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_4
HKD2_k127_3983573_1	215803.DB30_7802	4.118e-75	269.0	COG0491@1|root,COG0491@2|Bacteria,1MWVM@1224|Proteobacteria,439FY@68525|delta/epsilon subdivisions,2X4RR@28221|Deltaproteobacteria,2YZGB@29|Myxococcales	28221|Deltaproteobacteria	S	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3992081_0	1254432.SCE1572_38150	2.835e-134	434.0	COG0312@1|root,COG0312@2|Bacteria,1MUSK@1224|Proteobacteria,42QCV@68525|delta/epsilon subdivisions,2WJP8@28221|Deltaproteobacteria,2YUBA@29|Myxococcales	28221|Deltaproteobacteria	S	Putative modulator of DNA gyrase	tldD	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
HKD2_k127_3992081_2	1254432.SCE1572_38155	9.016e-05	44.0	COG0457@1|root,COG3170@1|root,COG0457@2|Bacteria,COG3170@2|Bacteria,1R7RK@1224|Proteobacteria,42PPY@68525|delta/epsilon subdivisions,2WKX6@28221|Deltaproteobacteria,2YUCP@29|Myxococcales	28221|Deltaproteobacteria	NU	Tetratricopeptide repeats	-	-	-	-	-	-	-	-	-	-	-	-	TPR_11,TPR_16,TPR_19
HKD2_k127_3994663_0	448385.sce0039	1.358e-46	174.0	COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,42MJB@68525|delta/epsilon subdivisions,2WIXF@28221|Deltaproteobacteria,2YUHY@29|Myxococcales	28221|Deltaproteobacteria	M	penicillin-binding protein	mrcA	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	iAF987.Gmet_0354	PCB_OB,Transgly,Transpeptidase
HKD2_k127_3998254_1	649638.Trad_0859	6.574e-50	190.0	COG1108@1|root,COG1108@2|Bacteria,1WJ32@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	P	ABC-type Mn2 Zn2 transport systems permease components	-	-	-	ko:K09816	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	ABC-3
HKD2_k127_3998254_0	1254432.SCE1572_37215	2.733e-67	241.0	COG0233@1|root,COG0233@2|Bacteria,1N66T@1224|Proteobacteria,42NAA@68525|delta/epsilon subdivisions,2WNMN@28221|Deltaproteobacteria,2YV1Q@29|Myxococcales	28221|Deltaproteobacteria	J	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another	frr	GO:0002181,GO:0002184,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043021,GO:0043023,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576	-	ko:K02838	-	-	-	-	ko00000,ko03012	-	-	-	RRF
HKD2_k127_3998548_0	861299.J421_1407	3.875e-38	148.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
HKD2_k127_3998548_1	448385.sce8789	5.509e-28	127.0	COG5662@1|root,COG5662@2|Bacteria	2|Bacteria	K	AntiSigma factor	actD	-	-	-	-	-	-	-	-	-	-	-	DUF4349,RskA
HKD2_k127_3998548_2	1254432.SCE1572_05205	5.469e-07	62.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin-like,EGF_CA,SLH
HKD2_k127_3999368_5	240016.ABIZ01000001_gene1689	8.585e-122	400.0	COG1902@1|root,COG1902@2|Bacteria,46SGZ@74201|Verrucomicrobia,2ITH2@203494|Verrucomicrobiae	203494|Verrucomicrobiae	C	NADH:flavin oxidoreductase / NADH oxidase family	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_FMN
HKD2_k127_3999368_7	1227488.C477_15345	1.497e-59	227.0	COG1575@1|root,arCOG00480@2157|Archaea,2XT1M@28890|Euryarchaeota,23TNU@183963|Halobacteria	183963|Halobacteria	H	Belongs to the MenA family. Type 1 subfamily	menA	-	2.5.1.74	ko:K02548	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R05617,R06858,R10757	RC02935,RC02936,RC03264	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
HKD2_k127_3999368_3	443143.GM18_0460	8.897e-139	450.0	COG1740@1|root,COG1740@2|Bacteria,1MWAC@1224|Proteobacteria,42MI0@68525|delta/epsilon subdivisions,2WIW4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	TIGRFAM hydrogenase (NiFe) small subunit (hydA)	hyaS	-	1.12.2.1,1.12.99.6	ko:K06282,ko:K18008	ko00633,ko01120,map00633,map01120	-	R08034	RC00250	ko00000,ko00001,ko01000	-	-	iAF987.Gmet_3332	NiFe_hyd_SSU_C,Oxidored_q6,TAT_signal
HKD2_k127_3999368_0	1121918.ARWE01000001_gene3504	1.129e-258	838.0	COG0374@1|root,COG0374@2|Bacteria,1MWFJ@1224|Proteobacteria,42M4S@68525|delta/epsilon subdivisions,2WJQS@28221|Deltaproteobacteria,43TIF@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Nickel-dependent hydrogenase	hyaL	-	1.12.99.6	ko:K06281	ko00633,ko01120,map00633,map01120	-	R08034	RC00250	ko00000,ko00001,ko01000	-	-	-	NiFeSe_Hases
HKD2_k127_3999368_8	1232410.KI421412_gene145	9.649e-45	186.0	COG1969@1|root,COG1969@2|Bacteria,1MU87@1224|Proteobacteria,42NQ3@68525|delta/epsilon subdivisions,2X8MJ@28221|Deltaproteobacteria,43TMS@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Domain of unknown function (DUF4405)	-	-	-	-	-	-	-	-	-	-	-	-	Ni_hydr_CYTB
HKD2_k127_3999368_11	269799.Gmet_3329	1.02e-30	136.0	COG0680@1|root,COG0680@2|Bacteria,1RE1C@1224|Proteobacteria,42REH@68525|delta/epsilon subdivisions,2WPXK@28221|Deltaproteobacteria,43VTP@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	PFAM peptidase M52 hydrogen uptake protein	hyaP	-	-	ko:K03605	-	-	-	-	ko00000,ko01000,ko01002	-	-	iAF987.Gmet_3329	HycI
HKD2_k127_3999368_1	290397.Adeh_0476	6.941e-251	802.0	COG0068@1|root,COG0068@2|Bacteria,1MVP8@1224|Proteobacteria,42M3G@68525|delta/epsilon subdivisions,2WJ51@28221|Deltaproteobacteria,2YTV0@29|Myxococcales	28221|Deltaproteobacteria	O	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide	hypF	-	-	ko:K04656	-	-	-	-	ko00000	-	-	-	Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF
HKD2_k127_3999368_10	290397.Adeh_0475	3.872e-32	128.0	COG0298@1|root,COG0298@2|Bacteria	2|Bacteria	O	carbon dioxide binding	hypC	-	-	ko:K04653,ko:K04654	-	-	-	-	ko00000	-	-	-	HupF_HypC
HKD2_k127_3999368_2	290397.Adeh_0474	5.034e-154	505.0	COG0409@1|root,COG0409@2|Bacteria,1MU1F@1224|Proteobacteria,42M6R@68525|delta/epsilon subdivisions,2WJDQ@28221|Deltaproteobacteria,2YTV5@29|Myxococcales	28221|Deltaproteobacteria	O	Belongs to the HypD family	hypD	-	-	ko:K04654	-	-	-	-	ko00000	-	-	iAF987.Gmet_0117	HypD
HKD2_k127_3999368_4	404589.Anae109_0515	7.519e-127	434.0	COG0309@1|root,COG0309@2|Bacteria,1MVCC@1224|Proteobacteria,42M3M@68525|delta/epsilon subdivisions,2WJ8B@28221|Deltaproteobacteria,2YTZM@29|Myxococcales	28221|Deltaproteobacteria	O	hydrogenase expression formation protein HypE	hypE	-	-	ko:K04655	-	-	-	-	ko00000	-	-	-	AIRS,AIRS_C
HKD2_k127_3999368_9	797209.ZOD2009_05272	7.005e-41	171.0	COG1024@1|root,arCOG00241@2157|Archaea,2XW1F@28890|Euryarchaeota,23TY0@183963|Halobacteria	183963|Halobacteria	I	Enoyl-CoA hydratase carnithine racemase	-	-	5.3.3.18	ko:K15866	ko00360,ko01120,map00360,map01120	-	R09837,R09839	RC00004,RC00326,RC02689,RC03003	ko00000,ko00001,ko01000	-	-	-	ECH_1
HKD2_k127_3999368_12	404589.Anae109_0514	1.524e-24	119.0	COG0375@1|root,COG0375@2|Bacteria,1MZJH@1224|Proteobacteria,42TGG@68525|delta/epsilon subdivisions	1224|Proteobacteria	S	Probably plays a role in a hydrogenase nickel cofactor insertion step	hypA	-	-	ko:K04651	-	-	-	-	ko00000,ko03110	-	-	-	HypA
HKD2_k127_3999368_6	404589.Anae109_0513	1.989e-92	312.0	COG0378@1|root,COG0378@2|Bacteria,1MVBD@1224|Proteobacteria,42MMJ@68525|delta/epsilon subdivisions,2WK7X@28221|Deltaproteobacteria	28221|Deltaproteobacteria	KO	TIGRFAM Hydrogenase accessory protein HypB	hypB	-	-	ko:K04652	-	-	-	-	ko00000,ko03110	-	-	-	cobW
HKD2_k127_3999368_14	512565.AMIS_29400	5.738e-05	49.0	COG2197@1|root,COG2197@2|Bacteria,2IC7E@201174|Actinobacteria	201174|Actinobacteria	K	PFAM regulatory protein LuxR	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GerE
HKD2_k127_4002477_1	1192034.CAP_6838	3.425e-56	209.0	COG2304@1|root,COG2304@2|Bacteria,1MW8K@1224|Proteobacteria,42Z9H@68525|delta/epsilon subdivisions,2WUIK@28221|Deltaproteobacteria,2YUAX@29|Myxococcales	28221|Deltaproteobacteria	K	protein containing a von Willebrand factor type A (vWA) domain	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VIT,VWA_3
HKD2_k127_4002477_0	448385.sce0944	7.001e-80	280.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,42Q67@68525|delta/epsilon subdivisions,2WKZ1@28221|Deltaproteobacteria	28221|Deltaproteobacteria	KLT	serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
HKD2_k127_4002477_3	292459.STH1114	5.59e-50	202.0	COG1015@1|root,COG1015@2|Bacteria,1UJAM@1239|Firmicutes,25EZP@186801|Clostridia	186801|Clostridia	C	Metalloenzyme superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Metalloenzyme
HKD2_k127_4002477_2	1254432.SCE1572_07005	1.534e-51	196.0	COG3339@1|root,COG3339@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF1232)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1232
HKD2_k127_4002477_4	448385.sce0933	2.078e-34	137.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria	1224|Proteobacteria	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HKD2_k127_4003530_3	1254432.SCE1572_10670	1.664e-23	103.0	COG2154@1|root,COG2154@2|Bacteria,1RIEN@1224|Proteobacteria,43765@68525|delta/epsilon subdivisions,2X24N@28221|Deltaproteobacteria,2YW4N@29|Myxococcales	28221|Deltaproteobacteria	H	pterin-4-alpha-carbinolamine dehydratase	-	-	4.2.1.96	ko:K01724	ko00790,map00790	-	R04734	RC01208	ko00000,ko00001,ko01000,ko04147	-	-	-	Pterin_4a
HKD2_k127_4003530_1	1254432.SCE1572_10675	5.395e-56	208.0	COG0571@1|root,COG0571@2|Bacteria,1MUQ6@1224|Proteobacteria,42MIP@68525|delta/epsilon subdivisions,2WNDB@28221|Deltaproteobacteria,2YVFW@29|Myxococcales	28221|Deltaproteobacteria	J	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism	rnc	GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004525,GO:0004540,GO:0005488,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0032296,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901363	3.1.26.3	ko:K03685	ko03008,ko05205,map03008,map05205	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019,ko03036	-	-	-	Ribonucleas_3_3,dsrm
HKD2_k127_4003530_0	1192034.CAP_7133	1.367e-59	224.0	COG0760@1|root,COG0760@2|Bacteria	2|Bacteria	O	peptidyl-prolyl cis-trans isomerase activity	surA	-	5.2.1.8	ko:K02597,ko:K03769,ko:K03771	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_2,Rotamase_3,SurA_N,SurA_N_3
HKD2_k127_4012894_8	448385.sce2826	6.399e-46	178.0	COG0457@1|root,COG0457@2|Bacteria,1R0CA@1224|Proteobacteria,43EDM@68525|delta/epsilon subdivisions,2X82F@28221|Deltaproteobacteria,2Z26J@29|Myxococcales	28221|Deltaproteobacteria	S	PEGA domain	-	-	-	-	-	-	-	-	-	-	-	-	PEGA
HKD2_k127_4012894_4	448385.sce4512	3.55e-99	341.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,42MVV@68525|delta/epsilon subdivisions,2X4JB@28221|Deltaproteobacteria,2YZ4I@29|Myxococcales	28221|Deltaproteobacteria	KLT	Family membership	-	-	2.7.11.1	ko:K08884	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HKD2_k127_4012894_2	1254432.SCE1572_22930	3.385e-119	390.0	COG0331@1|root,COG0331@2|Bacteria,1MV6N@1224|Proteobacteria,42MKH@68525|delta/epsilon subdivisions,2WIWQ@28221|Deltaproteobacteria,2YU16@29|Myxococcales	28221|Deltaproteobacteria	I	malonyl CoA-acyl carrier protein transacylase	fabD	-	2.3.1.39	ko:K00645	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	M00082	R01626,R11671	RC00004,RC00039,RC02727	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyl_transf_1
HKD2_k127_4012894_3	1192034.CAP_6146	5.489e-100	333.0	COG1028@1|root,COG1028@2|Bacteria,1MU6X@1224|Proteobacteria,42MB9@68525|delta/epsilon subdivisions,2WJ64@28221|Deltaproteobacteria,2YUT4@29|Myxococcales	28221|Deltaproteobacteria	IQ	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	fabG	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HKD2_k127_4012894_9	1254432.SCE1572_22920	7.434e-36	137.0	COG0236@1|root,COG0236@2|Bacteria,1MZ4P@1224|Proteobacteria,42V9M@68525|delta/epsilon subdivisions,2WRDW@28221|Deltaproteobacteria,2YVWU@29|Myxococcales	28221|Deltaproteobacteria	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	acpP	GO:0000035,GO:0000036,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016053,GO:0019637,GO:0019752,GO:0019842,GO:0031177,GO:0032787,GO:0033218,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044620,GO:0046394,GO:0046467,GO:0046493,GO:0048037,GO:0051192,GO:0071704,GO:0072330,GO:0072341,GO:0090407,GO:0140104,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
HKD2_k127_4012894_0	264462.Bd2010	1.667e-153	495.0	COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,42MUZ@68525|delta/epsilon subdivisions,2MSU8@213481|Bdellovibrionales,2WJT6@28221|Deltaproteobacteria	213481|Bdellovibrionales	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	fabF	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
HKD2_k127_4012894_6	1254432.SCE1572_22910	5.184e-53	192.0	COG1327@1|root,COG1327@2|Bacteria,1RE7V@1224|Proteobacteria,42SJP@68525|delta/epsilon subdivisions,2WPK0@28221|Deltaproteobacteria,2YVAV@29|Myxococcales	28221|Deltaproteobacteria	K	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes	nrdR	-	-	ko:K07738	-	-	-	-	ko00000,ko03000	-	-	-	ATP-cone
HKD2_k127_4012894_1	448385.sce3811	3.466e-133	440.0	COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,1MUWT@1224|Proteobacteria,42NBS@68525|delta/epsilon subdivisions,2WIP2@28221|Deltaproteobacteria,2YUVJ@29|Myxococcales	28221|Deltaproteobacteria	H	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate	ribD	-	1.1.1.193,3.5.4.26	ko:K11752	ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024	M00125	R03458,R03459	RC00204,RC00933	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_1624	RibD_C,dCMP_cyt_deam_1
HKD2_k127_4012894_5	448385.sce3810	8.443e-67	231.0	COG0242@1|root,COG0242@2|Bacteria,1RA2P@1224|Proteobacteria,42RFN@68525|delta/epsilon subdivisions,2WP25@28221|Deltaproteobacteria,2YVE0@29|Myxococcales	28221|Deltaproteobacteria	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions	def	-	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	Pep_deformylase
HKD2_k127_4012894_7	177437.HRM2_34780	6.816e-52	196.0	COG2050@1|root,COG2050@2|Bacteria,1N57X@1224|Proteobacteria,431HH@68525|delta/epsilon subdivisions,2WW6Z@28221|Deltaproteobacteria	28221|Deltaproteobacteria	Q	Thioesterase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT_3
HKD2_k127_4021625_0	357808.RoseRS_4538	6.819e-99	326.0	COG0667@1|root,COG0667@2|Bacteria,2G5V3@200795|Chloroflexi,377XZ@32061|Chloroflexia	32061|Chloroflexia	C	PFAM aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
HKD2_k127_4021625_3	321327.CYA_0280	0.0002173	53.0	COG5306@1|root,COG5306@2|Bacteria	2|Bacteria	-	-	exbB2	-	-	ko:K03561,ko:K12287	-	-	-	-	ko00000,ko02000,ko02044	1.A.30.2.1	-	-	DUF2341,Laminin_G_3,MotA_ExbB
HKD2_k127_4021625_2	331113.SNE_A18580	6.349e-17	90.0	COG3070@1|root,COG3070@2|Bacteria	2|Bacteria	K	positive regulation of type IV pilus biogenesis	-	-	-	ko:K07343	-	-	-	-	ko00000	-	-	-	TfoX_N
HKD2_k127_4021625_1	1192034.CAP_1837	3.111e-48	173.0	COG0100@1|root,COG0100@2|Bacteria,1RD0A@1224|Proteobacteria,42R43@68525|delta/epsilon subdivisions,2WPH1@28221|Deltaproteobacteria,2YVAP@29|Myxococcales	28221|Deltaproteobacteria	J	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome	rpsK	GO:0000028,GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0048027,GO:0065003,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02948	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S11
HKD2_k127_4029837_6	215803.DB30_3984	2.201e-30	124.0	COG0642@1|root,COG5002@1|root,COG2205@2|Bacteria,COG5002@2|Bacteria,1QX6W@1224|Proteobacteria,42ZK5@68525|delta/epsilon subdivisions,2WUSH@28221|Deltaproteobacteria,2YXKX@29|Myxococcales	28221|Deltaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_4
HKD2_k127_4029837_5	3067.XP_002953234.1	2.924e-40	169.0	COG1960@1|root,KOG0135@2759|Eukaryota,37Z91@33090|Viridiplantae,34K04@3041|Chlorophyta	3041|Chlorophyta	IQ	Acyl-CoA dehydrogenase, middle domain	-	-	1.3.3.6	ko:K00232	ko00071,ko00592,ko01040,ko01100,ko01110,ko01212,ko03320,ko04024,ko04146,map00071,map00592,map01040,map01100,map01110,map01212,map03320,map04024,map04146	M00087,M00113	R01175,R01279,R03777,R03857,R03990,R04751,R04754,R07888,R07892,R07896,R07934,R07950	RC00052,RC00076	ko00000,ko00001,ko00002,ko01000	-	-	-	ACOX,Acyl-CoA_dh_1,Acyl-CoA_dh_M
HKD2_k127_4029837_3	1192034.CAP_4352	1.026e-74	257.0	COG0558@1|root,COG0558@2|Bacteria,1RCZ7@1224|Proteobacteria,42QQ4@68525|delta/epsilon subdivisions,2WQGH@28221|Deltaproteobacteria,2YVBE@29|Myxococcales	28221|Deltaproteobacteria	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pgsA	-	2.7.8.5	ko:K00995	ko00564,ko01100,map00564,map01100	-	R01801	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
HKD2_k127_4029837_2	448385.sce2812	1.572e-94	329.0	COG0457@1|root,COG0457@2|Bacteria	448385.sce2812|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4029837_1	1254432.SCE1572_36110	8.447e-106	361.0	COG2515@1|root,COG2515@2|Bacteria,1MVYF@1224|Proteobacteria,42PWI@68525|delta/epsilon subdivisions,2WKFE@28221|Deltaproteobacteria,2YUTV@29|Myxococcales	28221|Deltaproteobacteria	E	Pyridoxal-phosphate dependent enzyme	-	-	4.4.1.15	ko:K05396	ko00270,map00270	-	R01874	RC00382	ko00000,ko00001,ko01000	-	-	-	PALP
HKD2_k127_4029837_4	1192034.CAP_4783	1.708e-41	160.0	COG4770@1|root,COG4770@2|Bacteria,1RJYU@1224|Proteobacteria,42WT6@68525|delta/epsilon subdivisions,2WSN5@28221|Deltaproteobacteria,2YVN7@29|Myxococcales	28221|Deltaproteobacteria	I	Biotin-requiring enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl
HKD2_k127_4029837_9	1036674.A28LD_0017	1.474e-05	59.0	COG1073@1|root,COG1073@2|Bacteria,1NVTC@1224|Proteobacteria,1RNXQ@1236|Gammaproteobacteria,2QFGB@267893|Idiomarinaceae	1236|Gammaproteobacteria	S	Bacterial virulence factor lipase N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_bact_N
HKD2_k127_4029837_0	1254432.SCE1572_11780	7.564e-207	689.0	COG0457@1|root,COG0515@1|root,COG3899@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG3899@2|Bacteria,1QA6R@1224|Proteobacteria,438FC@68525|delta/epsilon subdivisions,2X3QC@28221|Deltaproteobacteria,2YWU9@29|Myxococcales	28221|Deltaproteobacteria	KLT	Family membership	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,Pkinase
HKD2_k127_4029837_8	1192034.CAP_2972	1.245e-11	66.0	COG0826@1|root,COG0826@2|Bacteria,1MUQG@1224|Proteobacteria,42M8P@68525|delta/epsilon subdivisions,2WMKS@28221|Deltaproteobacteria,2YWJ3@29|Myxococcales	28221|Deltaproteobacteria	O	Collagenase	-	-	-	ko:K08303	ko05120,map05120	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	DUF3656,Peptidase_U32
HKD2_k127_4042012_3	518766.Rmar_1747	1.507e-15	90.0	COG0457@1|root,COG0457@2|Bacteria,4PMN3@976|Bacteroidetes	976|Bacteroidetes	M	ASPIC and UnbV	-	-	-	-	-	-	-	-	-	-	-	-	UnbV_ASPIC,VCBS
HKD2_k127_4042012_0	1192034.CAP_2501	7.404e-117	381.0	COG0345@1|root,COG0345@2|Bacteria,1R5J1@1224|Proteobacteria,42P7F@68525|delta/epsilon subdivisions,2WJW9@28221|Deltaproteobacteria,2YTWD@29|Myxococcales	28221|Deltaproteobacteria	E	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline	proC	-	1.5.1.2	ko:K00286	ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230	M00015	R01248,R01251,R03291,R03293	RC00054,RC00083	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_0899	F420_oxidored,P5CR_dimer
HKD2_k127_4042012_2	360104.CCC13826_1884	7.636e-21	108.0	COG0790@1|root,COG0790@2|Bacteria,1MWPA@1224|Proteobacteria,42UT8@68525|delta/epsilon subdivisions,2YPZM@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	M	beta-lactamase activity	-	-	-	ko:K07126	-	-	-	-	ko00000	-	-	-	Sel1
HKD2_k127_4042012_1	1254432.SCE1572_33285	7.242e-109	364.0	2DB8Y@1|root,2Z7TF@2|Bacteria,1MW4C@1224|Proteobacteria,43B9R@68525|delta/epsilon subdivisions,2X6NW@28221|Deltaproteobacteria,2YZWI@29|Myxococcales	28221|Deltaproteobacteria	S	Uncharacterized protein conserved in bacteria (DUF2236)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2236
HKD2_k127_4051069_0	1192034.CAP_0863	3.033e-90	303.0	COG1266@1|root,COG1266@2|Bacteria,1R5BW@1224|Proteobacteria,434JF@68525|delta/epsilon subdivisions,2WYWP@28221|Deltaproteobacteria,2Z0TD@29|Myxococcales	28221|Deltaproteobacteria	S	CAAX protease self-immunity	-	-	-	-	-	-	-	-	-	-	-	-	Abi
HKD2_k127_4051069_2	448385.sce2449	2.186e-07	59.0	COG0741@1|root,COG0741@2|Bacteria,1MZ4X@1224|Proteobacteria,42TVX@68525|delta/epsilon subdivisions,2WP4F@28221|Deltaproteobacteria,2YV7H@29|Myxococcales	28221|Deltaproteobacteria	M	Transglycosylase	-	-	-	ko:K08309	-	-	-	-	ko00000,ko01000,ko01011	-	GH23	-	DUF4124,SLT
HKD2_k127_4057637_1	448385.sce7698	9.44e-74	268.0	COG0148@1|root,COG0148@2|Bacteria,1MU1N@1224|Proteobacteria,42MS9@68525|delta/epsilon subdivisions,2WJMS@28221|Deltaproteobacteria,2YWXC@29|Myxococcales	28221|Deltaproteobacteria	F	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
HKD2_k127_4057637_0	215803.DB30_8717	3.792e-142	475.0	COG1199@1|root,COG1199@2|Bacteria,1MVCU@1224|Proteobacteria,42N57@68525|delta/epsilon subdivisions,2WJ82@28221|Deltaproteobacteria,2YUK7@29|Myxococcales	28221|Deltaproteobacteria	KL	SMART helicase c2	yoaA	-	3.6.4.12	ko:K03722	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_2,Helicase_C_2,ResIII
HKD2_k127_4068296_10	1192034.CAP_4141	5.571e-05	47.0	COG1544@1|root,COG1544@2|Bacteria,1MZHW@1224|Proteobacteria,42SJW@68525|delta/epsilon subdivisions,2WPF7@28221|Deltaproteobacteria,2YVRH@29|Myxococcales	28221|Deltaproteobacteria	J	Sigma 54 modulation protein / S30EA ribosomal protein	hpf	-	-	ko:K05808	-	-	-	-	ko00000,ko03009	-	-	-	Ribosom_S30AE_C,Ribosomal_S30AE
HKD2_k127_4068296_7	448385.sce5768	8.475e-37	144.0	COG1762@1|root,COG1762@2|Bacteria,1RD0E@1224|Proteobacteria,42SD2@68525|delta/epsilon subdivisions,2WP7H@28221|Deltaproteobacteria,2YVHR@29|Myxococcales	28221|Deltaproteobacteria	G	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2	ptsN	-	-	ko:K02806	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	-	-	-	PTS_EIIA_2
HKD2_k127_4068296_4	1254432.SCE1572_34255	8.178e-125	413.0	COG1493@1|root,COG1493@2|Bacteria,1NNN5@1224|Proteobacteria,42P9W@68525|delta/epsilon subdivisions,2WK54@28221|Deltaproteobacteria,2YUU0@29|Myxococcales	28221|Deltaproteobacteria	H	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr)	hprK	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K06023	-	-	-	-	ko00000,ko01000	-	-	-	Hpr_kinase_C,Hpr_kinase_N
HKD2_k127_4068296_5	448385.sce5766	3.991e-88	317.0	COG1660@1|root,COG1660@2|Bacteria,1MVX6@1224|Proteobacteria,42MZM@68525|delta/epsilon subdivisions,2WJG6@28221|Deltaproteobacteria,2YV1E@29|Myxococcales	28221|Deltaproteobacteria	S	Displays ATPase and GTPase activities	-	-	-	ko:K06958	-	-	-	-	ko00000,ko03019	-	-	-	ATP_bind_2
HKD2_k127_4068296_9	1254432.SCE1572_34245	1.771e-21	109.0	COG1925@1|root,COG1925@2|Bacteria,1N6RM@1224|Proteobacteria,42V5C@68525|delta/epsilon subdivisions,2WRC4@28221|Deltaproteobacteria,2YVUN@29|Myxococcales	28221|Deltaproteobacteria	G	Phosphocarrier protein HPR	ptsH	-	-	ko:K11189	-	-	-	-	ko00000,ko02000	4.A.2.1	-	-	PTS-HPr
HKD2_k127_4068296_1	1192034.CAP_4136	1.467e-190	617.0	COG1080@1|root,COG1080@2|Bacteria,1MUT8@1224|Proteobacteria,42P77@68525|delta/epsilon subdivisions,2WK7E@28221|Deltaproteobacteria,2YY2C@29|Myxococcales	28221|Deltaproteobacteria	G	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)	ptsI	-	2.7.1.202,2.7.3.9	ko:K02768,ko:K08483,ko:K11183	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	M00273	R03232	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.2.1,8.A.7	-	-	EIIA-man,PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C,PTS-HPr
HKD2_k127_4068296_0	1254432.SCE1572_34230	8.29e-218	702.0	COG0737@1|root,COG0737@2|Bacteria,1MX03@1224|Proteobacteria,42Q71@68525|delta/epsilon subdivisions,2WK8Q@28221|Deltaproteobacteria,2YY8A@29|Myxococcales	28221|Deltaproteobacteria	F	5'-nucleotidase, C-terminal domain	-	-	3.1.3.5,3.6.1.45	ko:K11751	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	5_nucleotid_C,Metallophos
HKD2_k127_4068296_6	1192034.CAP_4134	7.452e-68	252.0	COG2374@1|root,COG2374@2|Bacteria,1PC28@1224|Proteobacteria,4387J@68525|delta/epsilon subdivisions,2XA0Z@28221|Deltaproteobacteria,2YW3U@29|Myxococcales	28221|Deltaproteobacteria	S	Endonuclease Exonuclease Phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4068296_2	1192034.CAP_4133	5.565e-189	630.0	2AIU5@1|root,319B7@2|Bacteria,1Q28R@1224|Proteobacteria,437VQ@68525|delta/epsilon subdivisions,2X359@28221|Deltaproteobacteria,2YUC5@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4068296_3	448385.sce4543	6.533e-132	439.0	COG0515@1|root,COG0515@2|Bacteria,1QA6R@1224|Proteobacteria,43ARV@68525|delta/epsilon subdivisions,2X65Y@28221|Deltaproteobacteria,2Z39J@29|Myxococcales	448385.sce4543|-	KLT	Family membership	-	-	2.7.11.1	ko:K08884	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	-
HKD2_k127_4068296_8	401053.AciPR4_1846	6.329e-29	117.0	COG0184@1|root,COG0184@2|Bacteria,3Y55T@57723|Acidobacteria,2JJMX@204432|Acidobacteriia	204432|Acidobacteriia	J	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome	rpsO	-	-	ko:K02956	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S15
HKD2_k127_4068883_1	448385.sce5785	4.132e-78	276.0	COG2057@1|root,COG2057@2|Bacteria,1RA4V@1224|Proteobacteria,42PZY@68525|delta/epsilon subdivisions,2WJ9V@28221|Deltaproteobacteria,2YU5A@29|Myxococcales	28221|Deltaproteobacteria	I	Coenzyme A transferase	scoB	-	2.8.3.5	ko:K01029	ko00072,ko00280,ko00650,map00072,map00280,map00650	-	R00410	RC00014	ko00000,ko00001,ko01000	-	-	-	CoA_trans
HKD2_k127_4068883_0	1254432.SCE1572_34365	1.962e-126	410.0	COG1788@1|root,COG1788@2|Bacteria,1MVEI@1224|Proteobacteria,42QMC@68525|delta/epsilon subdivisions,2WMDH@28221|Deltaproteobacteria,2YU4I@29|Myxococcales	28221|Deltaproteobacteria	I	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit	scoA	-	2.8.3.5	ko:K01028	ko00072,ko00280,ko00650,map00072,map00280,map00650	-	R00410	RC00014	ko00000,ko00001,ko01000	-	-	-	CoA_trans
HKD2_k127_4068883_6	6238.CBG10108	4.113e-07	61.0	KOG1217@1|root,KOG1217@2759|Eukaryota,3A7ZT@33154|Opisthokonta,3BTJ6@33208|Metazoa,3D9X0@33213|Bilateria,40E93@6231|Nematoda,1KWNF@119089|Chromadorea,40RY9@6236|Rhabditida	33208|Metazoa	T	Worm-specific repeat type 1	-	-	-	-	-	-	-	-	-	-	-	-	CC
HKD2_k127_4068883_2	1254432.SCE1572_16740	1.192e-74	256.0	COG1573@1|root,COG1573@2|Bacteria,1Q2FJ@1224|Proteobacteria,43F3W@68525|delta/epsilon subdivisions,2X3BI@28221|Deltaproteobacteria,2YV9I@29|Myxococcales	28221|Deltaproteobacteria	L	Uracil DNA glycosylase superfamily	-	-	3.2.2.27	ko:K03648	ko03410,ko05340,map03410,map05340	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
HKD2_k127_4068883_3	1192034.CAP_6393	4.803e-65	231.0	COG0300@1|root,COG0300@2|Bacteria,1RDZP@1224|Proteobacteria,42SZK@68525|delta/epsilon subdivisions,2X5GI@28221|Deltaproteobacteria,2YWUT@29|Myxococcales	28221|Deltaproteobacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HKD2_k127_4068883_4	1254432.SCE1572_34355	1.496e-57	216.0	COG3770@1|root,COG3770@2|Bacteria	2|Bacteria	M	serine-type endopeptidase activity	-	-	-	ko:K07261	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_M74
HKD2_k127_4068883_5	1254432.SCE1572_34345	1.913e-34	137.0	COG0457@1|root,COG1672@1|root,COG0457@2|Bacteria,COG1672@2|Bacteria,1NB06@1224|Proteobacteria,43AS1@68525|delta/epsilon subdivisions,2X665@28221|Deltaproteobacteria,2YYB2@29|Myxococcales	28221|Deltaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,TPR_12,TPR_8
HKD2_k127_4084704_1	1192034.CAP_8920	3.973e-146	474.0	COG0366@1|root,COG0366@2|Bacteria,1MU90@1224|Proteobacteria,433YZ@68525|delta/epsilon subdivisions,2X44J@28221|Deltaproteobacteria,2YTX3@29|Myxococcales	28221|Deltaproteobacteria	G	Belongs to the glycosyl hydrolase 13 family	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase
HKD2_k127_4084704_4	1192034.CAP_7213	3.395e-104	356.0	COG4580@1|root,COG4580@2|Bacteria	2|Bacteria	M	maltodextrin transmembrane transporter activity	lamB	-	-	ko:K02024	-	-	-	-	ko00000,ko02000	1.B.3.1.1	-	-	LamB,Porin_8,Sugarporin_N
HKD2_k127_4084704_0	391625.PPSIR1_27703	2.222e-186	611.0	COG0296@1|root,COG0366@1|root,COG0296@2|Bacteria,COG0366@2|Bacteria,1MU90@1224|Proteobacteria,433VR@68525|delta/epsilon subdivisions,2X3PU@28221|Deltaproteobacteria,2YWT2@29|Myxococcales	28221|Deltaproteobacteria	G	Alpha-amylase domain	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase
HKD2_k127_4084704_5	1094980.Mpsy_2777	1.069e-39	156.0	COG1901@1|root,arCOG01239@2157|Archaea,2XTSB@28890|Euryarchaeota,2N9P7@224756|Methanomicrobia	224756|Methanomicrobia	J	Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs	trmY	-	2.1.1.257	ko:K16317	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltrn_RNA_2
HKD2_k127_4084704_3	1254432.SCE1572_06080	4.725e-113	380.0	COG1235@1|root,COG1235@2|Bacteria,1NW4Z@1224|Proteobacteria,42S6D@68525|delta/epsilon subdivisions,2WNEA@28221|Deltaproteobacteria,2Z344@29|Myxococcales	28221|Deltaproteobacteria	S	beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
HKD2_k127_4084704_6	1192034.CAP_6314	1.352e-22	115.0	COG1434@1|root,COG1434@2|Bacteria,1RF6P@1224|Proteobacteria,43ACD@68525|delta/epsilon subdivisions,2X5S6@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	DUF218 domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF218
HKD2_k127_4084704_2	1254432.SCE1572_06090	1.488e-117	411.0	COG0652@1|root,COG0652@2|Bacteria,1R4KH@1224|Proteobacteria,42R08@68525|delta/epsilon subdivisions,2WWSG@28221|Deltaproteobacteria,2YVBS@29|Myxococcales	28221|Deltaproteobacteria	M	Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD	-	-	5.2.1.8	ko:K03768	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	HEAT_2,Pro_isomerase
HKD2_k127_4084704_8	67352.JODS01000018_gene5756	2.242e-06	58.0	2A4S4@1|root,30TDJ@2|Bacteria,2I2TI@201174|Actinobacteria	201174|Actinobacteria	S	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4084704_7	1192034.CAP_5889	7.024e-20	91.0	COG1521@1|root,COG1521@2|Bacteria,1MUYA@1224|Proteobacteria,42MVZ@68525|delta/epsilon subdivisions,2WJ3N@28221|Deltaproteobacteria,2YTUR@29|Myxococcales	28221|Deltaproteobacteria	F	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis	coaX	-	2.7.1.33	ko:K03525	ko00770,ko01100,map00770,map01100	M00120	R02971,R03018,R04391	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_1986	Pan_kinase
HKD2_k127_4085643_3	1192034.CAP_5322	1.88e-09	63.0	COG0810@1|root,COG0810@2|Bacteria,1QARZ@1224|Proteobacteria,4359H@68525|delta/epsilon subdivisions,2WZKN@28221|Deltaproteobacteria,2Z2BQ@29|Myxococcales	2|Bacteria	M	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins	-	-	-	ko:K02487,ko:K03832,ko:K06596	ko02020,ko02025,map02020,map02025	M00507	-	-	ko00000,ko00001,ko00002,ko01001,ko02000,ko02022,ko02035	2.C.1.1	-	-	CarbopepD_reg_2,FabA,KAsynt_C_assoc,Ketoacyl-synt_C,TonB_2,TonB_C,ketoacyl-synt
HKD2_k127_4085643_1	1192034.CAP_5909	3.308e-121	413.0	COG3291@1|root,COG3291@2|Bacteria,1QEIS@1224|Proteobacteria,4389M@68525|delta/epsilon subdivisions,2X3J1@28221|Deltaproteobacteria,2YWAB@29|Myxococcales	28221|Deltaproteobacteria	S	IgGFc binding protein	-	-	-	-	-	-	-	-	-	-	-	-	IgGFc_binding
HKD2_k127_4085643_0	215803.DB30_5435	1.129e-143	464.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,42MK5@68525|delta/epsilon subdivisions,2WJ3Z@28221|Deltaproteobacteria,2YXAE@29|Myxococcales	28221|Deltaproteobacteria	C	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.3.8.1	ko:K00248	ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212	-	R01175,R01178,R02661,R03172,R04751	RC00052,RC00068,RC00076,RC00120,RC00148	ko00000,ko00001,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HKD2_k127_4085643_2	1254432.SCE1572_30870	4.823e-72	261.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,42MVV@68525|delta/epsilon subdivisions,2X4JB@28221|Deltaproteobacteria,2YZ4I@29|Myxococcales	28221|Deltaproteobacteria	KLT	Family membership	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HKD2_k127_4091245_10	1492922.GY26_05630	1.009e-18	96.0	2DP2V@1|root,330AH@2|Bacteria,1RAH8@1224|Proteobacteria,1S5I2@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function (DUF3455)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3455
HKD2_k127_4091245_7	448385.sce3481	1.121e-40	158.0	2AGMF@1|root,316UN@2|Bacteria,1PY1C@1224|Proteobacteria,43E04@68525|delta/epsilon subdivisions,2WZBK@28221|Deltaproteobacteria,2Z1SE@29|Myxococcales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF1109)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1109
HKD2_k127_4091245_5	448385.sce3482	2.85e-49	182.0	COG1595@1|root,COG1595@2|Bacteria,1Q4ZI@1224|Proteobacteria,42TYH@68525|delta/epsilon subdivisions,2WQNG@28221|Deltaproteobacteria,2YYP8@29|Myxococcales	28221|Deltaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	carQ	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
HKD2_k127_4091245_8	1227739.Hsw_0579	1.414e-28	132.0	COG3509@1|root,COG3509@2|Bacteria,4NHFS@976|Bacteroidetes,47RR1@768503|Cytophagia	976|Bacteroidetes	Q	Esterase PHB depolymerase	-	-	-	ko:K03932	-	-	-	-	ko00000	-	CE1	-	Abhydrolase_2,Esterase_phd
HKD2_k127_4091245_3	448385.sce3490	5.768e-88	317.0	COG0515@1|root,COG0515@2|Bacteria,1P2EB@1224|Proteobacteria,438NX@68525|delta/epsilon subdivisions,2X8TD@28221|Deltaproteobacteria,2YXD6@29|Myxococcales	28221|Deltaproteobacteria	KLT	Protein kinase domain	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
HKD2_k127_4091245_1	1192034.CAP_4442	1.872e-97	343.0	COG0515@1|root,COG0515@2|Bacteria	1192034.CAP_4442|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4091245_9	1278073.MYSTI_05810	9.131e-26	122.0	2AIX1@1|root,319EP@2|Bacteria,1Q2I0@1224|Proteobacteria,4384V@68525|delta/epsilon subdivisions,2X3EW@28221|Deltaproteobacteria,2YVRV@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4091245_2	448385.sce3562	1.067e-91	318.0	COG0515@1|root,COG0515@2|Bacteria	448385.sce3562|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4091245_13	696747.NIES39_A02840	0.0001502	55.0	COG0457@1|root,COG2319@1|root,COG0457@2|Bacteria,COG2319@2|Bacteria,1FZVW@1117|Cyanobacteria,1H8KE@1150|Oscillatoriales	1117|Cyanobacteria	K	PFAM WD domain, G-beta repeat	-	-	-	-	-	-	-	-	-	-	-	-	NB-ARC,WD40
HKD2_k127_4091245_0	1394178.AWOO02000127_gene1187	3.18e-127	442.0	COG2425@1|root,COG2425@2|Bacteria,2GK1P@201174|Actinobacteria,4EHUU@85012|Streptosporangiales	201174|Actinobacteria	S	VWA domain containing CoxE-like protein	-	-	-	-	-	-	-	-	-	-	-	-	VWA_CoxE
HKD2_k127_4091245_12	561175.KB894094_gene1798	4.442e-06	53.0	COG3296@1|root,COG3296@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF4870)	-	-	-	ko:K09940	-	-	-	-	ko00000	-	-	-	DUF4870
HKD2_k127_4091245_4	1123355.JHYO01000011_gene1419	3.27e-66	238.0	COG0678@1|root,COG0678@2|Bacteria,1MU0H@1224|Proteobacteria,2U6ZN@28211|Alphaproteobacteria,36YEB@31993|Methylocystaceae	28211|Alphaproteobacteria	O	Redoxin	MA20_20905	-	1.11.1.15	ko:K03386	ko04214,map04214	-	-	-	ko00000,ko00001,ko01000,ko04147	-	-	-	Redoxin
HKD2_k127_4091245_11	290397.Adeh_2141	3.405e-18	94.0	2DKFZ@1|root,309D6@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF4382)	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,DUF4382
HKD2_k127_4098072_5	1239962.C943_02095	1.493e-11	72.0	2ATWF@1|root,31JFP@2|Bacteria,4NQ9K@976|Bacteroidetes,47X6Y@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4098072_2	309801.trd_A0786	2.298e-35	156.0	COG0515@1|root,COG0515@2|Bacteria,2G7ZW@200795|Chloroflexi,27YUJ@189775|Thermomicrobia	189775|Thermomicrobia	KLT	Serine/Threonine protein kinases, catalytic domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HKD2_k127_4098072_4	219305.MCAG_02500	1.687e-31	144.0	COG5635@1|root,COG5635@2|Bacteria,2INWQ@201174|Actinobacteria,4DHHW@85008|Micromonosporales	201174|Actinobacteria	T	NACHT domain	-	-	-	-	-	-	-	-	-	-	-	-	NACHT
HKD2_k127_4098072_3	502025.Hoch_6306	4.132e-35	153.0	COG1716@1|root,COG1716@2|Bacteria,1REM9@1224|Proteobacteria,43232@68525|delta/epsilon subdivisions,2WWVT@28221|Deltaproteobacteria,2YZXE@29|Myxococcales	28221|Deltaproteobacteria	T	FHA domain	-	-	-	-	-	-	-	-	-	-	-	-	FHA
HKD2_k127_4098072_7	1278073.MYSTI_00586	0.0003668	48.0	2BA16@1|root,323EY@2|Bacteria,1QANF@1224|Proteobacteria,4356X@68525|delta/epsilon subdivisions,2WZI1@28221|Deltaproteobacteria,2Z26X@29|Myxococcales	28221|Deltaproteobacteria	S	Dickkopf N-terminal cysteine-rich region	-	-	-	-	-	-	-	-	-	-	-	-	Dickkopf_N
HKD2_k127_4098072_0	644801.Psest_4133	1.538e-93	331.0	COG4941@1|root,COG4941@2|Bacteria,1MU3D@1224|Proteobacteria,1RN25@1236|Gammaproteobacteria,1Z1IF@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	K	Belongs to the sigma-70 factor family	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2,TPR_2
HKD2_k127_4098072_6	1380386.JIAW01000018_gene2970	6.042e-07	60.0	COG3795@1|root,COG3795@2|Bacteria,2IQMR@201174|Actinobacteria,2357U@1762|Mycobacteriaceae	201174|Actinobacteria	S	YCII-related domain	-	-	-	-	-	-	-	-	-	-	-	-	YCII
HKD2_k127_4098072_1	1121373.KB903643_gene3558	1.761e-56	207.0	COG3832@1|root,COG3832@2|Bacteria,4NW0J@976|Bacteroidetes	976|Bacteroidetes	J	glyoxalase III activity	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
HKD2_k127_4099091_1	391008.Smal_0588	9.081e-06	50.0	COG1988@1|root,COG1988@2|Bacteria,1RBHW@1224|Proteobacteria,1S2F9@1236|Gammaproteobacteria,1X77S@135614|Xanthomonadales	135614|Xanthomonadales	S	LexA-binding, inner membrane-associated putative hydrolase	-	-	-	ko:K07038	-	-	-	-	ko00000	-	-	-	YdjM
HKD2_k127_4099091_0	502025.Hoch_3713	4.287e-87	315.0	COG0823@1|root,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	Big_3_2,CARDB,F5_F8_type_C,FlgD_ig,PD40,Prenyltrans
HKD2_k127_4110937_3	525904.Tter_1589	3.512e-33	137.0	COG1999@1|root,COG1999@2|Bacteria,2NP9U@2323|unclassified Bacteria	2|Bacteria	S	signal sequence binding	-	-	-	ko:K07152	-	-	-	-	ko00000,ko03029	-	-	-	SCO1-SenC
HKD2_k127_4110937_0	1192034.CAP_2028	2.148e-80	296.0	COG4531@1|root,COG4531@2|Bacteria,1REHQ@1224|Proteobacteria,42TZ1@68525|delta/epsilon subdivisions,2WQ6N@28221|Deltaproteobacteria,2YY91@29|Myxococcales	28221|Deltaproteobacteria	P	ABC-type Zn2 transport system, periplasmic component surface adhesin	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4110937_2	880073.Calab_0308	3.419e-42	171.0	COG2010@1|root,COG2010@2|Bacteria,2NPQJ@2323|unclassified Bacteria	2|Bacteria	C	Cytochrome C oxidase, cbb3-type, subunit III	actE	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
HKD2_k127_4110937_1	1089550.ATTH01000001_gene1173	2.884e-51	188.0	COG2010@1|root,COG2010@2|Bacteria,4NEX9@976|Bacteroidetes,1FJ8P@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	C	Protein of unknown function (DUF3341)	actD	-	-	-	-	-	-	-	-	-	-	-	DUF3341
HKD2_k127_4110937_4	880073.Calab_0310	7.337e-19	87.0	COG5557@1|root,COG5557@2|Bacteria,2NNNQ@2323|unclassified Bacteria	2|Bacteria	C	Polysulphide reductase, NrfD	actC	-	-	ko:K00185	-	-	-	-	ko00000	5.A.3	-	-	DUF3341,NrfD
HKD2_k127_4114941_0	448385.sce7960	1.124e-70	265.0	COG1262@1|root,COG1262@2|Bacteria	2|Bacteria	T	PFAM Formylglycine-generating sulfatase enzyme	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase,SapC
HKD2_k127_4114941_4	1463917.JODC01000004_gene6273	4.787e-18	96.0	COG0657@1|root,COG0657@2|Bacteria,2GNKU@201174|Actinobacteria	201174|Actinobacteria	I	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3,Peptidase_S9
HKD2_k127_4114941_1	1254432.SCE1572_37585	1.501e-46	185.0	COG2755@1|root,COG2755@2|Bacteria,1MXSG@1224|Proteobacteria,43476@68525|delta/epsilon subdivisions,2X9U4@28221|Deltaproteobacteria,2YV4A@29|Myxococcales	28221|Deltaproteobacteria	E	COG2755 Lysophospholipase L1 and related esterases	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
HKD2_k127_4114941_2	1192034.CAP_8953	5.302e-43	159.0	COG0297@1|root,COG0297@2|Bacteria,1MUGM@1224|Proteobacteria,42MT8@68525|delta/epsilon subdivisions,2WITI@28221|Deltaproteobacteria,2YU1G@29|Myxococcales	28221|Deltaproteobacteria	F	Synthesizes alpha-1,4-glucan chains using ADP-glucose	glgA	-	2.4.1.21	ko:K00703	ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026	M00565	R02421	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT5	-	Glyco_transf_5,Glycos_transf_1
HKD2_k127_4114973_5	1254432.SCE1572_27320	0.0001668	44.0	COG1463@1|root,COG1463@2|Bacteria,1MY8D@1224|Proteobacteria,42TCA@68525|delta/epsilon subdivisions,2WP6I@28221|Deltaproteobacteria,2YVND@29|Myxococcales	28221|Deltaproteobacteria	Q	ABC-type transport system involved in resistance to organic solvents periplasmic component	-	-	-	ko:K02067	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaD
HKD2_k127_4114973_1	1254432.SCE1572_00205	3.013e-38	156.0	COG0457@1|root,COG0457@2|Bacteria	1254432.SCE1572_00205|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4114973_0	1192034.CAP_5237	1.473e-58	220.0	COG0515@1|root,COG0515@2|Bacteria,1R0BG@1224|Proteobacteria,43EDB@68525|delta/epsilon subdivisions,2X819@28221|Deltaproteobacteria,2YWB1@29|Myxococcales	1192034.CAP_5237|-	KLT	Family membership	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4114973_3	1463845.JOIG01000004_gene4053	1.497e-06	53.0	COG0766@1|root,COG1396@1|root,COG0766@2|Bacteria,COG1396@2|Bacteria,2GJPW@201174|Actinobacteria	201174|Actinobacteria	M	Belongs to the EPSP synthase family. MurA subfamily	murA	-	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase,HTH_3
HKD2_k127_4117762_13	1254432.SCE1572_39025	0.0002625	53.0	29WSY@1|root,30IEA@2|Bacteria,1PV9U@1224|Proteobacteria,438BH@68525|delta/epsilon subdivisions,2X3KW@28221|Deltaproteobacteria,2YWGD@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4117762_6	483219.LILAB_03275	3.791e-80	273.0	COG2009@1|root,COG2009@2|Bacteria,1R7RY@1224|Proteobacteria,4329Z@68525|delta/epsilon subdivisions,2WYFY@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Succinate dehydrogenase/Fumarate reductase transmembrane subunit	sdhC	-	-	ko:K00241	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	Sdh_cyt
HKD2_k127_4117762_12	1192034.CAP_8242	2.428e-13	83.0	COG1506@1|root,COG1506@2|Bacteria	2|Bacteria	E	serine-type peptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	AXE1,Peptidase_S9
HKD2_k127_4117762_10	696281.Desru_1882	3.906e-36	152.0	COG0707@1|root,COG0707@2|Bacteria,1UQ6A@1239|Firmicutes,248FR@186801|Clostridia,2612Z@186807|Peptococcaceae	186801|Clostridia	M	PFAM Glycosyltransferase family 28 C-terminal domain	ugtP	-	2.4.1.315	ko:K03429	ko00561,ko01100,map00561,map01100	-	R02689,R04377	RC00005,RC00059	ko00000,ko00001,ko01000,ko01003	-	GT28	-	Glyco_tran_28_C,Glycos_transf_1,MGDG_synth
HKD2_k127_4117762_2	1254432.SCE1572_44810	8.503e-134	437.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,42NVJ@68525|delta/epsilon subdivisions,2WJN1@28221|Deltaproteobacteria,2YZ1H@29|Myxococcales	28221|Deltaproteobacteria	P	Belongs to the ABC transporter superfamily	-	-	3.6.3.20	ko:K05816,ko:K10112	ko02010,map02010	M00194,M00196,M00197,M00198,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.1,3.A.1.1.3	-	-	ABC_tran,TOBE_2
HKD2_k127_4117762_1	448385.sce7778	1.04e-227	728.0	COG1175@1|root,COG2182@1|root,COG1175@2|Bacteria,COG2182@2|Bacteria,1MXKR@1224|Proteobacteria,42UM4@68525|delta/epsilon subdivisions,2WQPJ@28221|Deltaproteobacteria,2YUAR@29|Myxococcales	28221|Deltaproteobacteria	P	Sugar ABC transporter permease	malF	-	-	ko:K10109,ko:K15770,ko:K15771	ko02010,map02010	M00194,M00491	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.1,3.A.1.1.16,3.A.1.1.2,3.A.1.1.22	-	-	BPD_transp_1,SBP_bac_8
HKD2_k127_4117762_11	1254432.SCE1572_44800	5.248e-14	78.0	COG3833@1|root,COG3833@2|Bacteria,1QA3Z@1224|Proteobacteria,42R4X@68525|delta/epsilon subdivisions,2WN1E@28221|Deltaproteobacteria,2YU8W@29|Myxococcales	28221|Deltaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K10110,ko:K15772	ko02010,map02010	M00194,M00491	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.1,3.A.1.1.16,3.A.1.1.2,3.A.1.1.22	-	-	BPD_transp_1
HKD2_k127_4117762_5	1254432.SCE1572_44800	1.038e-103	351.0	COG3833@1|root,COG3833@2|Bacteria,1QA3Z@1224|Proteobacteria,42R4X@68525|delta/epsilon subdivisions,2WN1E@28221|Deltaproteobacteria,2YU8W@29|Myxococcales	28221|Deltaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K10110,ko:K15772	ko02010,map02010	M00194,M00491	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.1,3.A.1.1.16,3.A.1.1.2,3.A.1.1.22	-	-	BPD_transp_1
HKD2_k127_4117762_4	316067.Geob_3361	6.244e-109	362.0	COG0016@1|root,COG0016@2|Bacteria,1MVD7@1224|Proteobacteria,42MB0@68525|delta/epsilon subdivisions,2WJ42@28221|Deltaproteobacteria,43TP6@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily	pheS	GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iAF987.Gmet_1415	Phe_tRNA-synt_N,tRNA-synt_2d
HKD2_k127_4117762_0	1192034.CAP_5522	2.842e-235	754.0	COG0072@1|root,COG0072@2|Bacteria,1MWKS@1224|Proteobacteria,42M1G@68525|delta/epsilon subdivisions,2WJ7V@28221|Deltaproteobacteria,2YYU4@29|Myxococcales	28221|Deltaproteobacteria	J	Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily	pheT	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,tRNA_bind
HKD2_k127_4117762_7	1192034.CAP_1710	3.664e-61	220.0	COG3745@1|root,COG3745@2|Bacteria,1NDG2@1224|Proteobacteria,42WK8@68525|delta/epsilon subdivisions,2WRTY@28221|Deltaproteobacteria,2YVNF@29|Myxococcales	28221|Deltaproteobacteria	U	Flp pilus assembly protein RcpC/CpaB	cpaB	-	-	ko:K02279	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	RcpC,SAF
HKD2_k127_4117762_3	1192034.CAP_1709	5.349e-118	403.0	COG4964@1|root,COG4964@2|Bacteria,1MV8G@1224|Proteobacteria,42PA6@68525|delta/epsilon subdivisions,2WIIY@28221|Deltaproteobacteria,2YZ3T@29|Myxococcales	28221|Deltaproteobacteria	U	Pilus formation protein N terminal region	-	-	-	ko:K02280	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	BON,Secretin,T2SS-T3SS_pil_N
HKD2_k127_4117762_9	1192034.CAP_1708	5.099e-44	171.0	COG4962@1|root,COG4962@2|Bacteria,1R7EN@1224|Proteobacteria,42NAK@68525|delta/epsilon subdivisions,2WIYX@28221|Deltaproteobacteria,2YTSI@29|Myxococcales	28221|Deltaproteobacteria	TU	Type II IV secretion system protein	-	-	-	ko:K02283,ko:K03609	-	-	-	-	ko00000,ko02035,ko02044,ko03036,ko04812	-	-	-	CbiA,FHA,T2SSE
HKD2_k127_4120280_1	1415779.JOMH01000001_gene159	5.13e-17	96.0	COG4188@1|root,COG4188@2|Bacteria,1QUVG@1224|Proteobacteria,1T22C@1236|Gammaproteobacteria,1X4WW@135614|Xanthomonadales	135614|Xanthomonadales	S	Bacterial virulence factor lipase N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_bact_N
HKD2_k127_4128972_1	439235.Dalk_1155	1.503e-88	305.0	COG1541@1|root,COG1541@2|Bacteria,1QA97@1224|Proteobacteria,43E7Y@68525|delta/epsilon subdivisions,2X5A4@28221|Deltaproteobacteria,2MPD8@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Acyl-protein synthetase, LuxE	-	-	-	-	-	-	-	-	-	-	-	-	LuxE
HKD2_k127_4128972_0	439235.Dalk_1156	5.988e-132	454.0	COG1012@1|root,COG1012@2|Bacteria,1N438@1224|Proteobacteria,432S7@68525|delta/epsilon subdivisions,2WXUZ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Acyl-CoA reductase (LuxC)	-	-	-	-	-	-	-	-	-	-	-	-	LuxC
HKD2_k127_4128972_2	448385.sce6045	0.0002257	54.0	COG3386@1|root,COG3386@2|Bacteria	2|Bacteria	G	gluconolactonase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF1080,HATPase_c,HisKA,NHL,Response_reg,SGL,Y_Y_Y
HKD2_k127_4131292_2	1192124.LIG30_4276	2.255e-104	347.0	COG0304@1|root,COG0304@2|Bacteria,1RB5A@1224|Proteobacteria,2VSQC@28216|Betaproteobacteria,1K91W@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Belongs to the beta-ketoacyl-ACP synthases family	-	-	-	ko:K00646	-	-	-	-	ko00000,ko01008	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
HKD2_k127_4131292_4	391625.PPSIR1_34382	3.087e-38	153.0	COG0764@1|root,COG0764@2|Bacteria,1NF10@1224|Proteobacteria,43217@68525|delta/epsilon subdivisions,2WWWK@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	FabA-like domain	-	-	4.2.1.59	ko:K02372	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07764,R10117,R10121	RC00831,RC01095	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FabA
HKD2_k127_4131292_3	391625.PPSIR1_34377	3.821e-69	263.0	COG0331@1|root,COG0331@2|Bacteria,1MV6N@1224|Proteobacteria,42MKH@68525|delta/epsilon subdivisions,2WIWQ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	malonyl CoA-acyl carrier protein transacylase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_1
HKD2_k127_4131292_0	391625.PPSIR1_34372	3.816e-147	490.0	COG0156@1|root,COG0156@2|Bacteria,1MVVH@1224|Proteobacteria,42MM1@68525|delta/epsilon subdivisions,2WIU7@28221|Deltaproteobacteria,2YX7Y@29|Myxococcales	28221|Deltaproteobacteria	E	Beta-eliminating lyase	bioF1	-	2.3.1.29,2.3.1.47	ko:K00639,ko:K00652	ko00260,ko00780,ko01100,map00260,map00780,map01100	M00123,M00573,M00577	R00371,R03210,R10124	RC00004,RC00039,RC00394,RC02725	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
HKD2_k127_4131292_1	517418.Ctha_0103	1.508e-132	435.0	COG0535@1|root,COG0535@2|Bacteria	2|Bacteria	I	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Fer4_14,Radical_SAM,SPASM
HKD2_k127_4131292_5	502025.Hoch_4101	1.058e-24	111.0	COG0664@1|root,COG0664@2|Bacteria,1QAZ0@1224|Proteobacteria,43E4R@68525|delta/epsilon subdivisions,2WZQH@28221|Deltaproteobacteria,2Z2IM@29|Myxococcales	28221|Deltaproteobacteria	K	Crp-like helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Crp_2,cNMP_binding
HKD2_k127_4156165_0	391625.PPSIR1_05733	7.153e-130	430.0	COG3291@1|root,COG3291@2|Bacteria,1QEIS@1224|Proteobacteria,4389M@68525|delta/epsilon subdivisions,2X3J1@28221|Deltaproteobacteria,2YWAB@29|Myxococcales	28221|Deltaproteobacteria	S	IgGFc binding protein	-	-	-	-	-	-	-	-	-	-	-	-	IgGFc_binding
HKD2_k127_4159186_2	1192034.CAP_3361	1.352e-58	213.0	COG5660@1|root,2Z7TM@2|Bacteria,1PMCV@1224|Proteobacteria,42Q81@68525|delta/epsilon subdivisions,2WIJ3@28221|Deltaproteobacteria,2Z2J1@29|Myxococcales	28221|Deltaproteobacteria	S	TRAP transporter T-component	-	-	-	-	-	-	-	-	-	-	-	-	TAtT
HKD2_k127_4159186_1	448385.sce7237	1.482e-66	239.0	COG1597@1|root,COG1597@2|Bacteria	2|Bacteria	I	lipid kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	DAGK_cat
HKD2_k127_4159186_4	749414.SBI_05314	1.626e-28	132.0	COG4987@1|root,COG4988@1|root,COG4987@2|Bacteria,COG4988@2|Bacteria,2I2DP@201174|Actinobacteria	201174|Actinobacteria	V	ABC transporter CydDC cysteine exporter (CydDC-E) family permease ATP-binding protein CydD	cydD	-	-	ko:K16013,ko:K16014	ko02010,map02010	-	-	-	ko00000,ko00001,ko02000	3.A.1.129	-	-	ABC_membrane,ABC_tran
HKD2_k127_4159186_0	1254432.SCE1572_42220	5.028e-168	546.0	COG0568@1|root,COG0568@2|Bacteria,1MVNJ@1224|Proteobacteria,42N2S@68525|delta/epsilon subdivisions,2WJ0E@28221|Deltaproteobacteria,2YYKC@29|Myxococcales	28221|Deltaproteobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	-	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
HKD2_k127_4174864_0	794903.OPIT5_22770	6.979e-88	304.0	COG0369@1|root,COG0369@2|Bacteria,46SEE@74201|Verrucomicrobia,3K7JJ@414999|Opitutae	414999|Opitutae	P	Oxidoreductase NAD-binding domain	-	-	1.8.1.2	ko:K00380	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00176	R00858	RC00065	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_1,Flavodoxin_1,NAD_binding_1
HKD2_k127_417596_0	1192034.CAP_7010	1.947e-163	529.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,1MVIW@1224|Proteobacteria,437VP@68525|delta/epsilon subdivisions,2WWNT@28221|Deltaproteobacteria,2YUC4@29|Myxococcales	28221|Deltaproteobacteria	G	repeat protein	agmK	-	-	-	-	-	-	-	-	-	-	-	Pkinase,TPR_16,TPR_19,TPR_7,TPR_8
HKD2_k127_41854_2	448385.sce8408	3.043e-93	313.0	COG1696@1|root,COG1696@2|Bacteria,1MUXN@1224|Proteobacteria,42MIR@68525|delta/epsilon subdivisions,2WMEK@28221|Deltaproteobacteria,2YU2I@29|Myxococcales	28221|Deltaproteobacteria	M	MBOAT, membrane-bound O-acyltransferase family	algI	-	-	ko:K19294	-	-	-	-	ko00000	-	-	-	MBOAT
HKD2_k127_41854_1	497965.Cyan7822_4628	1.145e-170	551.0	COG3288@1|root,COG3288@2|Bacteria,1G1D1@1117|Cyanobacteria,3KJEM@43988|Cyanothece	1117|Cyanobacteria	C	PFAM alanine dehydrogenase PNT domain protein	pntA	-	1.6.1.2	ko:K00324	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N,PNTB_4TM
HKD2_k127_41854_0	1192034.CAP_6746	1.932e-180	601.0	COG1282@1|root,COG1282@2|Bacteria,1MUP4@1224|Proteobacteria,42NHS@68525|delta/epsilon subdivisions,2WJHI@28221|Deltaproteobacteria,2YU3U@29|Myxococcales	28221|Deltaproteobacteria	C	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane	-	-	1.6.1.2	ko:K00325	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	PNTB
HKD2_k127_41854_3	502025.Hoch_3426	7.213e-22	111.0	COG1331@1|root,COG1331@2|Bacteria,1NF9Z@1224|Proteobacteria,43AQ1@68525|delta/epsilon subdivisions,2WXG6@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	Highly conserved protein containing a thioredoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4193810_3	1192034.CAP_2883	3.772e-60	209.0	COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,43AEE@68525|delta/epsilon subdivisions,2WIRF@28221|Deltaproteobacteria,2YU6I@29|Myxococcales	28221|Deltaproteobacteria	I	Carboxyl transferase domain	pccB	-	2.1.3.1,2.1.3.15,6.4.1.3	ko:K01966,ko:K17489	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R00353,R01859	RC00040,RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
HKD2_k127_4193810_8	1192034.CAP_0341	8.909e-05	56.0	COG0848@1|root,COG0848@2|Bacteria,1N8FU@1224|Proteobacteria,42WU3@68525|delta/epsilon subdivisions,2WSMD@28221|Deltaproteobacteria,2YW1Y@29|Myxococcales	28221|Deltaproteobacteria	U	Biopolymer transport protein ExbD/TolR	-	-	-	-	-	-	-	-	-	-	-	-	ExbD
HKD2_k127_4193810_5	265072.Mfla_2659	8.436e-25	106.0	COG3798@1|root,COG3798@2|Bacteria,1NMR4@1224|Proteobacteria,2W811@28216|Betaproteobacteria,2KN98@206350|Nitrosomonadales	206350|Nitrosomonadales	S	Uncharacterized protein conserved in bacteria (DUF2171)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2171
HKD2_k127_4193810_0	1192034.CAP_1125	1.034e-130	436.0	COG0533@1|root,COG0533@2|Bacteria,1MU6S@1224|Proteobacteria,42MHX@68525|delta/epsilon subdivisions,2WIKS@28221|Deltaproteobacteria,2YTSN@29|Myxococcales	28221|Deltaproteobacteria	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction	tsaD	GO:0000408,GO:0002949,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
HKD2_k127_4193810_2	426355.Mrad2831_0867	2.515e-62	219.0	COG1765@1|root,COG1765@2|Bacteria,1R9XU@1224|Proteobacteria,2U6E4@28211|Alphaproteobacteria,1JSFC@119045|Methylobacteriaceae	28211|Alphaproteobacteria	O	PFAM OsmC family protein	MA20_23315	-	-	-	-	-	-	-	-	-	-	-	OsmC
HKD2_k127_4193810_4	1384056.N787_14055	1.731e-56	201.0	COG1832@1|root,COG1832@2|Bacteria,1N03D@1224|Proteobacteria,1S3T2@1236|Gammaproteobacteria,1X7BR@135614|Xanthomonadales	135614|Xanthomonadales	S	CoA binding domain	-	-	-	-	-	-	-	-	-	-	-	-	CoA_binding_2
HKD2_k127_4193810_6	1254432.SCE1572_03310	9.095e-25	108.0	COG1664@1|root,COG1664@2|Bacteria,1ND4H@1224|Proteobacteria,43865@68525|delta/epsilon subdivisions,2X9Z0@28221|Deltaproteobacteria,2YVXK@29|Myxococcales	28221|Deltaproteobacteria	M	Integral membrane protein CcmA involved in cell shape determination	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
HKD2_k127_4193810_7	483219.LILAB_31120	6.155e-07	51.0	COG1664@1|root,COG1664@2|Bacteria,1RHS7@1224|Proteobacteria,433TD@68525|delta/epsilon subdivisions,2X9WK@28221|Deltaproteobacteria,2YVM0@29|Myxococcales	28221|Deltaproteobacteria	M	Integral membrane protein CcmA involved in cell shape determination	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
HKD2_k127_4206213_1	215803.DB30_5269	1.146e-57	201.0	COG0432@1|root,COG0432@2|Bacteria,1RA5G@1224|Proteobacteria,42QZ8@68525|delta/epsilon subdivisions,2WMV9@28221|Deltaproteobacteria,2YUYA@29|Myxococcales	28221|Deltaproteobacteria	S	Uncharacterised protein family UPF0047	-	-	-	-	-	-	-	-	-	-	-	-	UPF0047
HKD2_k127_4206213_0	1192034.CAP_1779	2.346e-119	388.0	COG0334@1|root,COG0334@2|Bacteria,1MUXS@1224|Proteobacteria,42PYC@68525|delta/epsilon subdivisions,2WMC4@28221|Deltaproteobacteria,2YUJR@29|Myxococcales	28221|Deltaproteobacteria	C	Belongs to the Glu Leu Phe Val dehydrogenases family	-	-	1.4.1.9	ko:K00263	ko00280,ko00290,ko01100,ko01110,ko01130,map00280,map00290,map01100,map01110,map01130	-	R01088,R01434,R02196	RC00006,RC00036	ko00000,ko00001,ko01000	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
HKD2_k127_4206624_8	517417.Cpar_0379	0.0008092	49.0	28IAZ@1|root,2Z8DG@2|Bacteria	2|Bacteria	S	DGQHR domain	-	-	-	-	-	-	-	-	-	-	-	-	DndB
HKD2_k127_4206624_0	1254432.SCE1572_37960	1.064e-243	782.0	COG1506@1|root,COG1506@2|Bacteria,1MUJ3@1224|Proteobacteria,42Q8W@68525|delta/epsilon subdivisions,2WJVN@28221|Deltaproteobacteria,2YWG3@29|Myxococcales	28221|Deltaproteobacteria	E	X-Pro dipeptidyl-peptidase (S15 family)	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9,Peptidase_S9_N
HKD2_k127_4206624_1	1254432.SCE1572_40880	5.658e-160	553.0	COG0457@1|root,COG0515@1|root,COG5616@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG5616@2|Bacteria,1MWVZ@1224|Proteobacteria,43APJ@68525|delta/epsilon subdivisions,2X638@28221|Deltaproteobacteria,2Z38P@29|Myxococcales	28221|Deltaproteobacteria	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HKD2_k127_4206624_4	502025.Hoch_6667	3.56e-104	362.0	COG0515@1|root,COG0515@2|Bacteria	502025.Hoch_6667|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4206624_3	1254432.SCE1572_46910	7.601e-112	391.0	COG0810@1|root,COG4772@1|root,COG0810@2|Bacteria,COG4772@2|Bacteria,1QVCH@1224|Proteobacteria,43C1Y@68525|delta/epsilon subdivisions,2X7CI@28221|Deltaproteobacteria,2Z3N7@29|Myxococcales	28221|Deltaproteobacteria	P	TonB-dependent Receptor Plug Domain	-	-	-	-	-	-	-	-	-	-	-	-	Plug
HKD2_k127_4206624_6	246197.MXAN_6967	5.896e-46	170.0	COG0735@1|root,COG0735@2|Bacteria,1NCW6@1224|Proteobacteria,42XS7@68525|delta/epsilon subdivisions,2WTAU@28221|Deltaproteobacteria,2YV43@29|Myxococcales	28221|Deltaproteobacteria	P	Belongs to the Fur family	-	-	-	ko:K03711	-	-	-	-	ko00000,ko03000	-	-	-	FUR
HKD2_k127_4206624_2	1192034.CAP_5423	1.022e-134	447.0	COG0520@1|root,COG0520@2|Bacteria,1MXH1@1224|Proteobacteria,43203@68525|delta/epsilon subdivisions,2WWMI@28221|Deltaproteobacteria,2YTY1@29|Myxococcales	28221|Deltaproteobacteria	E	DegT/DnrJ/EryC1/StrS aminotransferase family	cefD	-	5.1.1.17	ko:K04127	ko00311,ko01100,ko01130,map00311,map01100,map01130	M00673	R04147	RC00302	ko00000,ko00001,ko00002,ko01000	-	-	-	Aminotran_5
HKD2_k127_4206624_5	329726.AM1_2085	3.964e-104	349.0	COG1858@1|root,COG1858@2|Bacteria,1G35G@1117|Cyanobacteria	1117|Cyanobacteria	C	Di-haem cytochrome c peroxidase	-	-	1.11.1.5	ko:K00428	-	-	-	-	ko00000,ko01000	-	-	-	CCP_MauG,Cytochrom_C
HKD2_k127_4206624_7	398767.Glov_1654	3.745e-28	115.0	COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,42M7F@68525|delta/epsilon subdivisions,2WIMF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	NU	twitching motility protein	pilT-4	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
HKD2_k127_421015_0	44060.JODL01000004_gene2584	1.056e-65	239.0	COG0692@1|root,COG0692@2|Bacteria,2GJ9Z@201174|Actinobacteria	201174|Actinobacteria	L	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine	ung	GO:0003674,GO:0003824,GO:0004844,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006285,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097506,GO:0097510,GO:0140097,GO:1901360	3.2.2.27	ko:K03648	ko03410,ko05340,map03410,map05340	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
HKD2_k127_4217765_0	1192034.CAP_7495	2.414e-101	338.0	COG0213@1|root,COG0213@2|Bacteria,1MV3H@1224|Proteobacteria,42PCD@68525|delta/epsilon subdivisions,2WKGQ@28221|Deltaproteobacteria,2YU9M@29|Myxococcales	28221|Deltaproteobacteria	F	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis	pdp	-	2.4.2.2,2.4.2.4	ko:K00756,ko:K00758	ko00240,ko00983,ko01100,ko05219,map00240,map00983,map01100,map05219	-	R01570,R01876,R02296,R02484,R08222,R08230	RC00063	ko00000,ko00001,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3,PYNP_C
HKD2_k127_4217765_1	215803.DB30_3946	1.232e-53	206.0	COG0642@1|root,COG2205@2|Bacteria,1QX6V@1224|Proteobacteria,43BZK@68525|delta/epsilon subdivisions,2X7AC@28221|Deltaproteobacteria,2YYIJ@29|Myxococcales	28221|Deltaproteobacteria	T	GAF domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_4
HKD2_k127_4217765_2	1266998.ATUJ01000006_gene49	3.659e-39	152.0	COG0050@1|root,COG0050@2|Bacteria,1MVC0@1224|Proteobacteria,2TQP8@28211|Alphaproteobacteria,2PVIA@265|Paracoccus	28211|Alphaproteobacteria	J	GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
HKD2_k127_4222121_0	1254432.SCE1572_27360	9.434e-120	391.0	COG0441@1|root,COG0441@2|Bacteria,1MUP2@1224|Proteobacteria,42M20@68525|delta/epsilon subdivisions,2WJ2N@28221|Deltaproteobacteria,2YWDH@29|Myxococcales	28221|Deltaproteobacteria	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	-	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD
HKD2_k127_4222121_1	1254432.SCE1572_18555	5.022e-36	152.0	COG1633@1|root,COG1633@2|Bacteria,1QA00@1224|Proteobacteria,434PZ@68525|delta/epsilon subdivisions,2X8YV@28221|Deltaproteobacteria,2Z13N@29|Myxococcales	28221|Deltaproteobacteria	S	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_422232_1	1192034.CAP_3040	3.604e-69	243.0	COG1360@1|root,COG5316@1|root,COG1360@2|Bacteria,COG5316@2|Bacteria	2|Bacteria	N	Flagellar Motor Protein	-	-	-	ko:K11892	ko03070,map03070	M00334	-	-	ko00000,ko00001,ko00002,ko02044	3.A.23.1	-	-	DUF4139,DotU,OmpA
HKD2_k127_422232_7	192875.XP_004365387.1	2.809e-19	100.0	KOG4693@1|root,KOG4693@2759|Eukaryota	2759|Eukaryota	S	meiotic cell cycle	LZTR1	GO:0003674,GO:0003700,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005794,GO:0006355,GO:0008150,GO:0009653,GO:0009889,GO:0010468,GO:0010556,GO:0012505,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0032502,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464,GO:0048856,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1903506,GO:2000112,GO:2001141	4.4.1.28	ko:K15216,ko:K16474,ko:K20285,ko:K22207	ko00270,map00270	-	R00782	RC00382	ko00000,ko00001,ko01000,ko03021,ko03036,ko04131	-	-	-	BTB,Kelch_1,Kelch_3,Kelch_4,Kelch_5
HKD2_k127_422232_9	483219.LILAB_14375	4.766e-15	86.0	2APHR@1|root,31EKS@2|Bacteria,1QBX0@1224|Proteobacteria,435IF@68525|delta/epsilon subdivisions,2WZW3@28221|Deltaproteobacteria,2Z2VA@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_422232_0	1254432.SCE1572_45980	1.903e-157	511.0	COG1071@1|root,COG1071@2|Bacteria,1MU5R@1224|Proteobacteria,42NW8@68525|delta/epsilon subdivisions,2WJY1@28221|Deltaproteobacteria,2YY6R@29|Myxococcales	28221|Deltaproteobacteria	C	Dehydrogenase E1 component	bkdA	-	1.2.4.1,1.2.4.4	ko:K00161,ko:K00166	ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00036,M00307	R00014,R00209,R01699,R03270,R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00004,RC00027,RC00627,RC02742,RC02743,RC02744,RC02882,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
HKD2_k127_422232_10	1242864.D187_006783	1.654e-07	63.0	2ANK1@1|root,31DJ4@2|Bacteria,1QAV1@1224|Proteobacteria,435BA@68525|delta/epsilon subdivisions,2WZNP@28221|Deltaproteobacteria,2Z2FG@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_422232_3	448385.sce8134	8.296e-43	169.0	2CDI5@1|root,2Z7ZQ@2|Bacteria,1Q9TA@1224|Proteobacteria,42QB0@68525|delta/epsilon subdivisions,2WMJT@28221|Deltaproteobacteria,2Z1T9@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_422232_2	448385.sce8004	7.418e-49	186.0	COG1413@1|root,COG1413@2|Bacteria,1QAW1@1224|Proteobacteria,43E4E@68525|delta/epsilon subdivisions,2WZPH@28221|Deltaproteobacteria,2Z2H1@29|Myxococcales	28221|Deltaproteobacteria	C	HEAT repeats	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2
HKD2_k127_422232_6	1242864.D187_002014	7.358e-27	126.0	COG1173@1|root,COG1173@2|Bacteria,1MW3R@1224|Proteobacteria,43AQ5@68525|delta/epsilon subdivisions,2X63Y@28221|Deltaproteobacteria,2Z3A5@29|Myxococcales	28221|Deltaproteobacteria	U	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
HKD2_k127_422232_4	1125863.JAFN01000001_gene1631	3.253e-37	156.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,42P18@68525|delta/epsilon subdivisions,2WKFV@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	PFAM binding-protein-dependent transport systems inner membrane component	dppB	-	-	ko:K02033,ko:K12369,ko:K13890	ko02010,ko02024,map02010,map02024	M00239,M00324,M00348	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.11	-	-	BPD_transp_1
HKD2_k127_422232_5	1192034.CAP_2173	1.661e-27	120.0	2ANM7@1|root,31DKH@2|Bacteria,1QAWY@1224|Proteobacteria,435CB@68525|delta/epsilon subdivisions,2WZPX@28221|Deltaproteobacteria,2Z2HJ@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_422232_11	1192034.CAP_2172	8.055e-05	46.0	COG1145@1|root,COG1145@2|Bacteria,1MZ6H@1224|Proteobacteria,42U8W@68525|delta/epsilon subdivisions,2X3DV@28221|Deltaproteobacteria,2YVMF@29|Myxococcales	28221|Deltaproteobacteria	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_7
HKD2_k127_4228112_2	546266.NEIMUCOT_04752	6.339e-24	106.0	COG0063@1|root,COG0063@2|Bacteria,1MU1Q@1224|Proteobacteria,2VJZD@28216|Betaproteobacteria,2KPNK@206351|Neisseriales	206351|Neisseriales	H	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	-	4.2.1.136	ko:K17758	-	-	-	-	ko00000,ko01000	-	-	-	Carb_kinase,YjeF_N
HKD2_k127_4228112_1	448385.sce0322	4.859e-51	186.0	COG1595@1|root,COG1595@2|Bacteria,1PEJM@1224|Proteobacteria,4380A@68525|delta/epsilon subdivisions,2X3AB@28221|Deltaproteobacteria,2YV3Y@29|Myxococcales	28221|Deltaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	rpoE	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD2_k127_4228112_0	530564.Psta_4139	8.837e-52	188.0	COG2096@1|root,COG2096@2|Bacteria,2IZZ0@203682|Planctomycetes	203682|Planctomycetes	S	PFAM Cobalamin adenosyltransferase	-	-	2.5.1.17	ko:K00798	ko00860,ko01100,map00860,map01100	M00122	R01492,R05220,R07268	RC00533	ko00000,ko00001,ko00002,ko01000	-	-	-	Cob_adeno_trans
HKD2_k127_4246828_0	448385.sce4845	1.626e-142	479.0	COG0460@1|root,COG0460@2|Bacteria,1MUDC@1224|Proteobacteria,42MGS@68525|delta/epsilon subdivisions,2WJ1K@28221|Deltaproteobacteria,2YU5H@29|Myxococcales	28221|Deltaproteobacteria	E	homoserine dehydrogenase	hom	-	1.1.1.3	ko:K00003	ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00017,M00018	R01773,R01775	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,Homoserine_dh,NAD_binding_3
HKD2_k127_4246828_3	448385.sce3490	9.269e-78	292.0	COG0515@1|root,COG0515@2|Bacteria,1P2EB@1224|Proteobacteria,438NX@68525|delta/epsilon subdivisions,2X8TD@28221|Deltaproteobacteria,2YXD6@29|Myxococcales	28221|Deltaproteobacteria	KLT	Protein kinase domain	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
HKD2_k127_4246828_6	404589.Anae109_1648	2.931e-25	118.0	COG5592@1|root,COG5592@2|Bacteria	2|Bacteria	I	hemerythrin HHE cation binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin,Phasin_2
HKD2_k127_4246828_9	869210.Marky_0479	7.916e-11	73.0	COG0517@1|root,COG0517@2|Bacteria,1WJ0F@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	CBS domain	-	-	-	ko:K04767	-	-	-	-	ko00000	-	-	-	ACT,CBS
HKD2_k127_4246828_5	240292.Ava_4090	3.143e-36	156.0	COG1278@1|root,COG1278@2|Bacteria,1G5DM@1117|Cyanobacteria,1HMJV@1161|Nostocales	1117|Cyanobacteria	K	'Cold-shock' DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	CSD,Ribosomal_S30AE
HKD2_k127_4246828_1	517418.Ctha_1616	2.139e-127	417.0	COG1858@1|root,COG1858@2|Bacteria,1FDVA@1090|Chlorobi	1090|Chlorobi	C	PFAM Di-haem cytochrome c peroxidase	-	-	1.11.1.5	ko:K00428	-	-	-	-	ko00000,ko01000	-	-	-	CCP_MauG,Cytochrom_C
HKD2_k127_4246828_7	248742.XP_005650113.1	1.603e-14	84.0	28KQ9@1|root,2QRKW@2759|Eukaryota,37JAP@33090|Viridiplantae,34HU4@3041|Chlorophyta	3041|Chlorophyta	S	Chlorophyllase	-	-	-	-	-	-	-	-	-	-	-	-	Chlorophyllase2
HKD2_k127_4246828_4	1444711.CCJF01000005_gene1539	1.492e-63	231.0	COG2898@1|root,COG2898@2|Bacteria,2JGQP@204428|Chlamydiae	204428|Chlamydiae	S	Uncharacterised conserved protein (DUF2156)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2156
HKD2_k127_4246828_2	448385.sce8599	1.37e-122	406.0	2A4BQ@1|root,30SXD@2|Bacteria,1PCFN@1224|Proteobacteria,438EV@68525|delta/epsilon subdivisions,2WYPE@28221|Deltaproteobacteria,2YWSY@29|Myxococcales	28221|Deltaproteobacteria	S	IgGFc binding protein	-	-	-	-	-	-	-	-	-	-	-	-	IgGFc_binding
HKD2_k127_424979_0	1192034.CAP_2716	4.602e-88	308.0	COG1995@1|root,COG1995@2|Bacteria,1MX5W@1224|Proteobacteria,42NJJ@68525|delta/epsilon subdivisions,2WJGI@28221|Deltaproteobacteria,2YV17@29|Myxococcales	28221|Deltaproteobacteria	C	Belongs to the PdxA family	pdxA	-	1.1.1.262,1.1.1.408,1.1.1.409	ko:K00097,ko:K22024	ko00750,ko01100,map00750,map01100	M00124	R05681,R05837,R07406	RC00089,RC00675,RC01475	ko00000,ko00001,ko00002,ko01000	-	-	-	PdxA
HKD2_k127_424979_2	448385.sce6445	3.395e-63	225.0	COG0745@1|root,COG0745@2|Bacteria,1QA39@1224|Proteobacteria,43DXD@68525|delta/epsilon subdivisions,2WZ4F@28221|Deltaproteobacteria,2Z1B4@29|Myxococcales	28221|Deltaproteobacteria	K	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Trans_reg_C
HKD2_k127_424979_4	1144275.COCOR_05277	1.848e-10	72.0	COG3064@1|root,COG3064@2|Bacteria,1QX7A@1224|Proteobacteria,43C08@68525|delta/epsilon subdivisions,2X7AZ@28221|Deltaproteobacteria,2YYPY@29|Myxococcales	28221|Deltaproteobacteria	M	YXWGXW repeat (2 copies)	-	-	-	-	-	-	-	-	-	-	-	-	YXWGXW
HKD2_k127_424979_3	386456.JQKN01000001_gene2133	3.984e-46	174.0	COG0500@1|root,arCOG01787@2157|Archaea,2XYWK@28890|Euryarchaeota	28890|Euryarchaeota	Q	Methyltransferase domain	-	-	-	ko:K15256	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltransf_12,Methyltransf_25
HKD2_k127_424979_1	448385.sce6446	1.156e-75	254.0	COG0312@1|root,COG0312@2|Bacteria,1MUSK@1224|Proteobacteria,42QCV@68525|delta/epsilon subdivisions,2WJP8@28221|Deltaproteobacteria,2YUBA@29|Myxococcales	28221|Deltaproteobacteria	S	Putative modulator of DNA gyrase	tldD	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
HKD2_k127_4250279_0	448385.sce0252	0.0	1235.0	COG0457@1|root,COG2956@1|root,COG3118@1|root,COG0457@2|Bacteria,COG2956@2|Bacteria,COG3118@2|Bacteria,1MVIW@1224|Proteobacteria,4391J@68525|delta/epsilon subdivisions,2X472@28221|Deltaproteobacteria,2YYDY@29|Myxococcales	28221|Deltaproteobacteria	GO	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_19,TPR_6,TPR_7,TPR_8
HKD2_k127_4250279_2	448385.sce3432	3.45e-55	202.0	COG0204@1|root,COG0204@2|Bacteria,1MY51@1224|Proteobacteria,42S1J@68525|delta/epsilon subdivisions,2WP2S@28221|Deltaproteobacteria,2YVUS@29|Myxococcales	28221|Deltaproteobacteria	I	Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family	-	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
HKD2_k127_4250279_1	483219.LILAB_10400	1.287e-73	269.0	COG1597@1|root,COG1597@2|Bacteria,1Q3AR@1224|Proteobacteria,4391Z@68525|delta/epsilon subdivisions,2X47J@28221|Deltaproteobacteria,2YYF6@29|Myxococcales	28221|Deltaproteobacteria	I	Diacylglycerol kinase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	DAGK_cat
HKD2_k127_4250279_3	215803.DB30_0682	1.256e-35	138.0	COG1331@1|root,COG1331@2|Bacteria,1MUUT@1224|Proteobacteria,43BWP@68525|delta/epsilon subdivisions,2X77H@28221|Deltaproteobacteria,2YXA7@29|Myxococcales	28221|Deltaproteobacteria	O	Protein of unknown function, DUF255	-	-	-	-	-	-	-	-	-	-	-	-	Thioredox_DsbH
HKD2_k127_4250279_4	172088.AUGA01000004_gene3905	4.629e-27	120.0	COG1331@1|root,COG1331@2|Bacteria,1MUUT@1224|Proteobacteria,2TV0X@28211|Alphaproteobacteria,3JXPF@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	O	Protein of unknown function, DUF255	-	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	GlcNAc_2-epim,Thioredox_DsbH
HKD2_k127_4255368_0	1144275.COCOR_01156	1.16e-108	366.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2YU4M@29|Myxococcales	28221|Deltaproteobacteria	T	Bacterial regulatory protein, Fis family	sasR	-	-	ko:K07713	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD2_k127_4255368_1	1144275.COCOR_01086	2.758e-27	123.0	COG3852@1|root,COG3852@2|Bacteria,1QVPN@1224|Proteobacteria	1224|Proteobacteria	T	Histidine kinase	pilS	-	2.7.13.3	ko:K02668	ko02020,map02020	M00501	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	HATPase_c,HisKA,HisKA_7TM,PAS_4,PAS_8
HKD2_k127_4256352_1	1192034.CAP_6237	4.662e-42	164.0	COG5164@1|root,COG5164@2|Bacteria,1R0C5@1224|Proteobacteria,43CUH@68525|delta/epsilon subdivisions,2X826@28221|Deltaproteobacteria,2Z24H@29|Myxococcales	28221|Deltaproteobacteria	K	regulation of DNA-templated transcription, elongation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4256352_2	545264.KB898755_gene2826	1.089e-31	130.0	COG0607@1|root,COG0607@2|Bacteria,1N70J@1224|Proteobacteria,1SE5K@1236|Gammaproteobacteria,1X1AU@135613|Chromatiales	135613|Chromatiales	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
HKD2_k127_4256352_0	1192034.CAP_2405	6.536e-77	284.0	COG1413@1|root,COG1413@2|Bacteria	2|Bacteria	C	deoxyhypusine monooxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,HEAT_PBS,NB-ARC,cNMP_binding
HKD2_k127_4277608_3	1254432.SCE1572_17750	8.905e-41	157.0	COG2972@1|root,COG2972@2|Bacteria,1QA94@1224|Proteobacteria,434WZ@68525|delta/epsilon subdivisions,2WZ7X@28221|Deltaproteobacteria,2Z1IT@29|Myxococcales	28221|Deltaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4277608_4	448385.sce2910	4.681e-37	151.0	COG1413@1|root,COG1413@2|Bacteria,1Q31D@1224|Proteobacteria,438RI@68525|delta/epsilon subdivisions,2X3YG@28221|Deltaproteobacteria,2YXKK@29|Myxococcales	28221|Deltaproteobacteria	C	HEAT repeats	cpcE	-	-	-	-	-	-	-	-	-	-	-	HEAT_2
HKD2_k127_4277608_0	448385.sce2908	3.737e-119	395.0	COG0552@1|root,COG0552@2|Bacteria,1MUDU@1224|Proteobacteria,42N3Z@68525|delta/epsilon subdivisions,2WIPM@28221|Deltaproteobacteria,2YY2A@29|Myxococcales	28221|Deltaproteobacteria	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components	ftsY	-	-	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2,3.A.5.7	-	-	SRP54,SRP54_N
HKD2_k127_4277608_1	1192034.CAP_0167	1.146e-99	336.0	2DCII@1|root,2ZE9Y@2|Bacteria,1PA1F@1224|Proteobacteria,433KQ@68525|delta/epsilon subdivisions,2WYI5@28221|Deltaproteobacteria,2YW5W@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4282449_0	1192034.CAP_0379	1.597e-77	274.0	COG1409@1|root,COG1409@2|Bacteria	2|Bacteria	S	acid phosphatase activity	ppe2	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K22390	-	-	-	-	ko00000	-	-	-	Metallophos,Pur_ac_phosph_N,TAT_signal
HKD2_k127_4282449_1	1192034.CAP_0379	1.632e-74	268.0	COG1409@1|root,COG1409@2|Bacteria	2|Bacteria	S	acid phosphatase activity	ppe2	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K22390	-	-	-	-	ko00000	-	-	-	Metallophos,Pur_ac_phosph_N,TAT_signal
HKD2_k127_4283023_0	1380394.JADL01000001_gene2679	5.428e-146	473.0	COG0654@1|root,COG0654@2|Bacteria,1P1NX@1224|Proteobacteria,2TRZX@28211|Alphaproteobacteria	28211|Alphaproteobacteria	CH	PFAM monooxygenase FAD-binding	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3
HKD2_k127_4283023_1	378806.STAUR_2012	1.922e-48	181.0	2DB7V@1|root,2Z7NX@2|Bacteria,1N9SI@1224|Proteobacteria,43ANT@68525|delta/epsilon subdivisions,2WTAF@28221|Deltaproteobacteria,2YYSS@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4284873_0	448385.sce8632	4.241e-114	372.0	COG1024@1|root,COG1024@2|Bacteria,1MWZC@1224|Proteobacteria,43AS4@68525|delta/epsilon subdivisions,2X669@28221|Deltaproteobacteria,2Z39V@29|Myxococcales	28221|Deltaproteobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
HKD2_k127_4284873_2	1297742.A176_03534	8.353e-15	87.0	COG0845@1|root,COG0845@2|Bacteria	2|Bacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	alg44	-	2.4.1.33	ko:K01991,ko:K02005,ko:K06147,ko:K12542,ko:K16552,ko:K19291	ko00051,ko02025,ko02026,map00051,map02025,map02026	M00330	R08692	RC00005	ko00000,ko00001,ko00002,ko01000,ko02000,ko02044	1.B.18,1.B.18.1,3.A.1.106,3.A.1.109,3.A.1.109.4,3.A.1.21,8.A.1	-	-	HlyD_3,PilZ,YtkA
HKD2_k127_4284873_1	521674.Plim_1307	5.5e-86	298.0	COG1045@1|root,COG1045@2|Bacteria,2IX5K@203682|Planctomycetes	203682|Planctomycetes	E	COG1045 Serine acetyltransferase	-	-	2.3.1.30	ko:K00640	ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111	M00021	R00586	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep
HKD2_k127_4298050_4	448385.sce9055	3.058e-79	273.0	COG0313@1|root,COG0313@2|Bacteria,1MU0E@1224|Proteobacteria,42P3I@68525|delta/epsilon subdivisions,2WM37@28221|Deltaproteobacteria,2YV9J@29|Myxococcales	28221|Deltaproteobacteria	H	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA	rsmI	-	2.1.1.198	ko:K07056	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TP_methylase
HKD2_k127_4298050_6	1254432.SCE1572_00790	1.686e-38	160.0	COG3391@1|root,COG3391@2|Bacteria,1Q2JN@1224|Proteobacteria,4386H@68525|delta/epsilon subdivisions,2X9ZH@28221|Deltaproteobacteria,2YVZH@29|Myxococcales	28221|Deltaproteobacteria	S	Beta-L-arabinofuranosidase, GH127	-	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3,Stig1
HKD2_k127_4298050_5	448385.sce6529	4.114e-48	181.0	COG0695@1|root,COG0695@2|Bacteria,1PPNM@1224|Proteobacteria,437CJ@68525|delta/epsilon subdivisions,2X2I6@28221|Deltaproteobacteria,2Z2DY@29|Myxococcales	28221|Deltaproteobacteria	O	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins	-	-	-	-	-	-	-	-	-	-	-	-	Glutaredoxin
HKD2_k127_4298050_0	448385.sce6528	3.547e-248	781.0	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,42M2A@68525|delta/epsilon subdivisions,2WIJY@28221|Deltaproteobacteria,2YUEB@29|Myxococcales	28221|Deltaproteobacteria	S	ATPase components of ABC transporters with duplicated ATPase domains	-	-	-	ko:K06158	-	-	-	-	ko00000,ko03012	-	-	-	ABC_tran,ABC_tran_Xtn
HKD2_k127_4298050_7	1267533.KB906736_gene883	2.857e-38	150.0	COG2215@1|root,COG2215@2|Bacteria,3Y79H@57723|Acidobacteria,2JM3I@204432|Acidobacteriia	204432|Acidobacteriia	S	High-affinity nickel-transport protein	-	-	-	ko:K07241	-	-	-	-	ko00000,ko02000	2.A.52.1	-	-	NicO
HKD2_k127_4298050_1	483219.LILAB_19900	4.14e-140	457.0	COG1157@1|root,COG1157@2|Bacteria,1MUH6@1224|Proteobacteria,42M0K@68525|delta/epsilon subdivisions,2WISR@28221|Deltaproteobacteria	28221|Deltaproteobacteria	NU	PFAM H transporting two-sector ATPase alpha beta subunit central region	fliI	-	3.6.3.14	ko:K02412,ko:K03224	ko02040,ko03070,map02040,map03070	M00332,M00542,M00660	-	-	ko00000,ko00001,ko00002,ko01000,ko02035,ko02044	3.A.6.1,3.A.6.2,3.A.6.3	-	-	ATP-synt_ab,ATP-synt_ab_N
HKD2_k127_4298050_9	1254432.SCE1572_01410	1.99e-11	73.0	COG1633@1|root,COG1633@2|Bacteria	2|Bacteria	S	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)	-	-	1.16.3.1	ko:K03594	ko00860,map00860	-	R00078	RC02758	ko00000,ko00001,ko01000	-	-	-	Ferritin,Ferritin-like
HKD2_k127_4298050_2	448385.sce1669	4.384e-118	391.0	COG0484@1|root,COG0484@2|Bacteria,1MVMS@1224|Proteobacteria,42KZM@68525|delta/epsilon subdivisions,2WJGP@28221|Deltaproteobacteria,2YXG3@29|Myxococcales	28221|Deltaproteobacteria	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
HKD2_k127_4298050_8	497964.CfE428DRAFT_3827	1.152e-11	78.0	COG3210@1|root,COG4932@1|root,COG3210@2|Bacteria,COG4932@2|Bacteria	2|Bacteria	M	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4298050_10	448385.sce4513	7.875e-10	72.0	COG0457@1|root,COG0457@2|Bacteria	448385.sce4513|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4298050_3	448385.sce5636	6.336e-84	296.0	COG0515@1|root,COG0515@2|Bacteria,1PJRR@1224|Proteobacteria	1224|Proteobacteria	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	DUF4384,PEGA,Pkinase,TPR_12
HKD2_k127_4299450_0	448385.sce6263	1.641e-99	338.0	COG3202@1|root,COG3202@2|Bacteria,1MVP5@1224|Proteobacteria,438CB@68525|delta/epsilon subdivisions,2X3MN@28221|Deltaproteobacteria,2YWIY@29|Myxococcales	28221|Deltaproteobacteria	C	ATP ADP translocase	-	-	-	ko:K03301	-	-	-	-	ko00000	2.A.12	-	-	-
HKD2_k127_4299450_2	1160137.KB907308_gene6729	3.072e-28	134.0	COG0515@1|root,COG0515@2|Bacteria,2GNXG@201174|Actinobacteria,4FWPS@85025|Nocardiaceae	201174|Actinobacteria	KLT	Protein tyrosine kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HKD2_k127_4299450_1	1278073.MYSTI_05853	3.368e-66	252.0	COG0457@1|root,COG0457@2|Bacteria	1278073.MYSTI_05853|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4299450_3	479434.Sthe_3254	2.638e-21	109.0	COG1287@1|root,COG1287@2|Bacteria,2G75T@200795|Chloroflexi,27XID@189775|Thermomicrobia	189775|Thermomicrobia	S	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HKD2_k127_4303545_0	404589.Anae109_1248	9.806e-138	445.0	COG0171@1|root,COG0171@2|Bacteria,1QHZ4@1224|Proteobacteria,42QD8@68525|delta/epsilon subdivisions,2WMK9@28221|Deltaproteobacteria,2YZFC@29|Myxococcales	28221|Deltaproteobacteria	H	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source	nadE	-	6.3.1.5	ko:K01916	ko00760,ko01100,map00760,map01100	M00115	R00189	RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	NAD_synthase
HKD2_k127_4303545_1	765698.Mesci_5375	3.659e-114	374.0	COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,2TSCY@28211|Alphaproteobacteria,43IMQ@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	Asparagine synthase	asnB	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_6,GATase_7
HKD2_k127_430764_4	926560.KE387023_gene2069	1.976e-56	217.0	COG3616@1|root,COG3616@2|Bacteria	2|Bacteria	E	Alanine racemase, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Ala_racemase_N
HKD2_k127_430764_5	1121946.AUAX01000019_gene7790	1.947e-36	159.0	COG0388@1|root,COG0388@2|Bacteria	2|Bacteria	S	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	-	-	-	-	-	-	-	-	-	-	-	-	CN_hydrolase
HKD2_k127_430764_8	1038869.AXAN01000047_gene4503	0.0005895	53.0	COG4409@1|root,COG4409@2|Bacteria	2|Bacteria	G	exo-alpha-(2->6)-sialidase activity	-	-	-	-	-	-	-	-	-	-	-	-	ASH,BNR_2,Big_3_2,CBM_35,DUF1080,F5_F8_type_C,PKD,RicinB_lectin_2,Trehalase
HKD2_k127_430764_7	395019.Bmul_4351	9.148e-15	87.0	293C9@1|root,2ZQUV@2|Bacteria,1P74T@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_430764_0	1333998.M2A_2842	1.509e-144	483.0	COG2303@1|root,COG2303@2|Bacteria,1MU3F@1224|Proteobacteria,2TT3C@28211|Alphaproteobacteria,4BPZW@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	E	GMC oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GMC_oxred_C,GMC_oxred_N,NAD_binding_8
HKD2_k127_430764_3	502025.Hoch_4302	6.752e-61	236.0	COG0300@1|root,COG0300@2|Bacteria,1QX60@1224|Proteobacteria,43BYK@68525|delta/epsilon subdivisions,2X79H@28221|Deltaproteobacteria,2Z3EC@29|Myxococcales	28221|Deltaproteobacteria	S	NAD dependent epimerase/dehydratase family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HKD2_k127_430764_6	1254432.SCE1572_31845	2.95e-20	103.0	COG4775@1|root,COG4775@2|Bacteria	2|Bacteria	M	membrane organization	-	-	-	ko:K07126,ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,PD40,POTRA
HKD2_k127_430764_1	1254432.SCE1572_17540	1.11e-88	305.0	28J9N@1|root,2Z94I@2|Bacteria,1RJV8@1224|Proteobacteria,42TFJ@68525|delta/epsilon subdivisions,2WP6D@28221|Deltaproteobacteria,2YUR0@29|Myxococcales	28221|Deltaproteobacteria	S	Uncharacterized conserved protein (DUF2293)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2293
HKD2_k127_430764_2	1254432.SCE1572_13340	4.96e-61	217.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,42MVV@68525|delta/epsilon subdivisions,2X4JB@28221|Deltaproteobacteria,2YZ4I@29|Myxococcales	28221|Deltaproteobacteria	KLT	Family membership	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HKD2_k127_4308632_7	448385.sce7634	6.421e-15	78.0	COG3266@1|root,COG3266@2|Bacteria,1PBVF@1224|Proteobacteria,4384T@68525|delta/epsilon subdivisions,2X3EV@28221|Deltaproteobacteria,2YVRI@29|Myxococcales	28221|Deltaproteobacteria	S	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	dCache_3
HKD2_k127_4308632_6	1254432.SCE1572_12550	4.545e-16	90.0	COG3031@1|root,COG3031@2|Bacteria,1R0C6@1224|Proteobacteria,43CUI@68525|delta/epsilon subdivisions,2X827@28221|Deltaproteobacteria,2Z2GE@29|Myxococcales	28221|Deltaproteobacteria	U	protein transport across the cell outer membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4308632_2	448385.sce0834	1.912e-53	195.0	COG0125@1|root,COG0125@2|Bacteria,1MV9C@1224|Proteobacteria,42RK3@68525|delta/epsilon subdivisions,2WN3N@28221|Deltaproteobacteria,2YVHP@29|Myxococcales	28221|Deltaproteobacteria	F	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis	tmk	-	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylate_kin
HKD2_k127_4308632_1	1254432.SCE1572_05890	2.701e-97	326.0	COG0414@1|root,COG0414@2|Bacteria,1MV1S@1224|Proteobacteria,42N3J@68525|delta/epsilon subdivisions,2WJ19@28221|Deltaproteobacteria,2YUVT@29|Myxococcales	28221|Deltaproteobacteria	H	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate	panC	GO:0003674,GO:0003824,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006573,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605	6.3.2.1	ko:K01918	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R02473	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_ligase
HKD2_k127_4308632_5	1192034.CAP_5877	1.5e-25	121.0	COG0457@1|root,COG0457@2|Bacteria	1192034.CAP_5877|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4321330_1	502025.Hoch_0089	2.51e-104	372.0	COG1304@1|root,COG1304@2|Bacteria,1MUEZ@1224|Proteobacteria,42T5F@68525|delta/epsilon subdivisions,2WQVP@28221|Deltaproteobacteria,2YU42@29|Myxococcales	28221|Deltaproteobacteria	C	FMN-dependent dehydrogenase	-	-	1.1.3.46	ko:K16422	ko00261,ko01055,ko01130,map00261,map01055,map01130	-	R06633	RC00240	ko00000,ko00001,ko01000	-	-	-	FMN_dh
HKD2_k127_4321330_3	1392540.P256_01212	3.564e-17	89.0	COG1108@1|root,COG1108@2|Bacteria,1R07X@1224|Proteobacteria,1T4T2@1236|Gammaproteobacteria,3NPZS@468|Moraxellaceae	1236|Gammaproteobacteria	P	ABC-type Mn2 Zn2 transport systems permease components	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4321330_0	448385.sce0116	3.491e-139	461.0	COG0154@1|root,COG0154@2|Bacteria,1MW3Z@1224|Proteobacteria,42Z6J@68525|delta/epsilon subdivisions,2WUD7@28221|Deltaproteobacteria,2YWHK@29|Myxococcales	28221|Deltaproteobacteria	J	Amidase	-	-	-	-	-	-	-	-	-	-	-	-	Amidase
HKD2_k127_4321330_2	4952.CAG82336	2.261e-19	93.0	COG0657@1|root,KOG1515@2759|Eukaryota,3A1CU@33154|Opisthokonta,3NZ98@4751|Fungi,3QKHV@4890|Ascomycota,3RVXJ@4891|Saccharomycetes	4751|Fungi	V	Carboxylesterase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3
HKD2_k127_4345784_0	448385.sce4778	4.232e-103	344.0	COG0515@1|root,COG0515@2|Bacteria	448385.sce4778|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4345784_2	215803.DB30_0544	6.599e-71	265.0	COG4395@1|root,COG4395@2|Bacteria,1NKJZ@1224|Proteobacteria,43793@68525|delta/epsilon subdivisions,2X2CB@28221|Deltaproteobacteria,2YYKJ@29|Myxococcales	28221|Deltaproteobacteria	S	Tim44	-	-	-	-	-	-	-	-	-	-	-	-	Tim44
HKD2_k127_4345784_4	448385.sce8890	2.046e-21	109.0	COG0457@1|root,COG0457@2|Bacteria	448385.sce8890|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4345784_3	1254432.SCE1572_50770	8.674e-37	151.0	COG0457@1|root,COG0457@2|Bacteria	1254432.SCE1572_50770|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4345784_1	448385.sce8895	3.071e-87	292.0	COG0104@1|root,COG0104@2|Bacteria,1MU5B@1224|Proteobacteria,42M9E@68525|delta/epsilon subdivisions,2WJ3F@28221|Deltaproteobacteria,2YUGA@29|Myxococcales	28221|Deltaproteobacteria	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
HKD2_k127_434917_2	1192034.CAP_7142	1.979e-27	114.0	COG2908@1|root,COG2908@2|Bacteria	2|Bacteria	M	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	-	-	3.6.1.54	ko:K03269	ko00540,ko01100,map00540,map01100	M00060	R04549	RC00002	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Metallophos,Metallophos_2
HKD2_k127_434917_1	448385.sce5820	1.042e-57	220.0	2CDCQ@1|root,307SM@2|Bacteria,1QST3@1224|Proteobacteria,4355I@68525|delta/epsilon subdivisions,2WZGF@28221|Deltaproteobacteria,2Z23I@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_434917_0	502025.Hoch_0225	2.218e-94	315.0	COG3483@1|root,COG3483@2|Bacteria,1MW68@1224|Proteobacteria,42YUJ@68525|delta/epsilon subdivisions,2WTUY@28221|Deltaproteobacteria,2YVT1@29|Myxococcales	28221|Deltaproteobacteria	E	Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety	kynA	GO:0003674,GO:0003824,GO:0004833,GO:0005488,GO:0006082,GO:0006520,GO:0006568,GO:0006569,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009072,GO:0009074,GO:0009308,GO:0009310,GO:0009987,GO:0016043,GO:0016054,GO:0016491,GO:0016701,GO:0016702,GO:0019439,GO:0019441,GO:0019752,GO:0020037,GO:0022607,GO:0034641,GO:0042180,GO:0042402,GO:0042430,GO:0042436,GO:0042537,GO:0043436,GO:0043933,GO:0044085,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0046218,GO:0046395,GO:0046483,GO:0046700,GO:0046906,GO:0048037,GO:0051213,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0070189,GO:0071704,GO:0071840,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	1.13.11.11	ko:K00453	ko00380,ko01100,map00380,map01100	M00038	R00678	RC00356	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_dioxygenase
HKD2_k127_4371139_2	1254432.SCE1572_15085	2.535e-65	239.0	COG0706@1|root,COG0706@2|Bacteria,1MV5M@1224|Proteobacteria,42MS8@68525|delta/epsilon subdivisions,2WJB6@28221|Deltaproteobacteria,2YV0H@29|Myxococcales	28221|Deltaproteobacteria	U	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins	yidC	-	-	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03029	2.A.9	-	-	60KD_IMP,YidC_periplas
HKD2_k127_4371139_4	448385.sce2521	1.266e-25	109.0	COG0759@1|root,COG0759@2|Bacteria,1N6U4@1224|Proteobacteria,42VNC@68525|delta/epsilon subdivisions,2WRIM@28221|Deltaproteobacteria,2YW1U@29|Myxococcales	28221|Deltaproteobacteria	S	Could be involved in insertion of integral membrane proteins into the membrane	-	-	-	ko:K08998	-	-	-	-	ko00000	-	-	-	Haemolytic
HKD2_k127_4371139_6	1254432.SCE1572_15090	1.101e-24	108.0	COG0594@1|root,COG0594@2|Bacteria,1NGQJ@1224|Proteobacteria,42VBC@68525|delta/epsilon subdivisions,2WRF0@28221|Deltaproteobacteria,2YVYX@29|Myxococcales	28221|Deltaproteobacteria	J	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme	rnpA	-	3.1.26.5	ko:K03536	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Ribonuclease_P
HKD2_k127_4371139_7	448385.sce2523	1.597e-13	72.0	COG0230@1|root,COG0230@2|Bacteria	2|Bacteria	J	Ribosomal protein L34	rpmH	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02914	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L34
HKD2_k127_4371139_1	448385.sce2524	3.742e-126	424.0	COG2885@1|root,COG2885@2|Bacteria,1R8DG@1224|Proteobacteria,42NGC@68525|delta/epsilon subdivisions,2WMAP@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Belongs to the ompA family	-	-	-	ko:K03286	-	-	-	-	ko00000,ko02000	1.B.6	-	-	OmpA,Phenol_MetA_deg,TSP_3,VWA
HKD2_k127_4371139_3	1386089.N865_09660	1.57e-55	214.0	COG1680@1|root,COG1680@2|Bacteria,2GNNF@201174|Actinobacteria	201174|Actinobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase,DUF3471
HKD2_k127_4371139_0	215803.DB30_7011	1.153e-164	546.0	COG4772@1|root,COG4772@2|Bacteria,1QVCH@1224|Proteobacteria,43C1Y@68525|delta/epsilon subdivisions,2X7CI@28221|Deltaproteobacteria,2Z3FE@29|Myxococcales	28221|Deltaproteobacteria	P	TonB dependent receptor	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
HKD2_k127_4371139_5	1034345.CAEM01000001_gene444	1.04e-24	122.0	COG0864@1|root,COG0864@2|Bacteria,2HUWY@201174|Actinobacteria,4CVWV@84998|Coriobacteriia	84998|Coriobacteriia	K	transcriptional regulator	-	-	-	ko:K07722	-	-	-	-	ko00000,ko03000	-	-	-	NikR_C,RHH_1
HKD2_k127_4376055_1	1192034.CAP_4001	5.531e-71	260.0	2AIZE@1|root,319HE@2|Bacteria,1Q2SG@1224|Proteobacteria,438E3@68525|delta/epsilon subdivisions,2X3P8@28221|Deltaproteobacteria,2YWR0@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4376055_0	448385.sce5274	4.306e-111	378.0	COG2067@1|root,COG2067@2|Bacteria,1Q2WT@1224|Proteobacteria,438JN@68525|delta/epsilon subdivisions,2X3UB@28221|Deltaproteobacteria,2YX4H@29|Myxococcales	28221|Deltaproteobacteria	I	Outer membrane protein transport protein (OMPP1/FadL/TodX)	-	-	-	ko:K06076	-	-	-	-	ko00000,ko02000	1.B.9	-	-	Toluene_X
HKD2_k127_4376055_3	1254432.SCE1572_10170	9.599e-22	100.0	COG0741@1|root,COG1388@1|root,COG3064@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,COG3064@2|Bacteria,1MWKE@1224|Proteobacteria,42MWF@68525|delta/epsilon subdivisions,2WKAQ@28221|Deltaproteobacteria,2Z2XM@29|Myxococcales	28221|Deltaproteobacteria	M	Lysin motif	-	-	-	ko:K08307	-	-	-	-	ko00000,ko01000,ko01011	-	-	-	LysM,SLT
HKD2_k127_4380029_2	179408.Osc7112_1476	3.261e-50	183.0	COG1090@1|root,COG1090@2|Bacteria,1G1NR@1117|Cyanobacteria,1H9DM@1150|Oscillatoriales	1117|Cyanobacteria	S	PFAM NAD dependent epimerase dehydratase family	-	-	-	ko:K07071	-	-	-	-	ko00000	-	-	-	DUF1731,Epimerase
HKD2_k127_4380029_0	1278073.MYSTI_00357	4.273e-218	696.0	COG3158@1|root,COG3158@2|Bacteria,1MUVH@1224|Proteobacteria,42P5Y@68525|delta/epsilon subdivisions,2WJEH@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	Transport of potassium into the cell	kup	GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015672,GO:0016020,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0098655,GO:0098660,GO:0098662	-	ko:K03549	-	-	-	-	ko00000,ko02000	2.A.72	-	-	K_trans
HKD2_k127_4380029_1	439235.Dalk_3036	9.113e-70	248.0	COG1226@1|root,COG1226@2|Bacteria,1MU1R@1224|Proteobacteria,42MW6@68525|delta/epsilon subdivisions,2WN2R@28221|Deltaproteobacteria,2MMYS@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Ion channel	-	-	-	-	-	-	-	-	-	-	-	-	Ion_trans_2,TrkA_C,TrkA_N
HKD2_k127_4401291_8	525368.HMPREF0591_2271	2.366e-11	77.0	COG3340@1|root,COG3340@2|Bacteria,2IC7Y@201174|Actinobacteria,234WT@1762|Mycobacteriaceae	201174|Actinobacteria	E	Peptidase family S51	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S51
HKD2_k127_4401291_6	448385.sce0426	6.441e-21	97.0	COG0607@1|root,COG0607@2|Bacteria,1REHH@1224|Proteobacteria,42SFZ@68525|delta/epsilon subdivisions,2WPY5@28221|Deltaproteobacteria,2Z0Z7@29|Myxococcales	28221|Deltaproteobacteria	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
HKD2_k127_4401291_2	1192034.CAP_3803	1.192e-91	337.0	COG1413@1|root,COG1413@2|Bacteria,1PYBK@1224|Proteobacteria,43E33@68525|delta/epsilon subdivisions,2WZJM@28221|Deltaproteobacteria,2Z29W@29|Myxococcales	28221|Deltaproteobacteria	C	HEAT repeats	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2
HKD2_k127_4401291_1	1192034.CAP_1808	2.276e-96	330.0	COG0768@1|root,COG0768@2|Bacteria,1R7A0@1224|Proteobacteria,42MJC@68525|delta/epsilon subdivisions,2WJZ2@28221|Deltaproteobacteria,2YV14@29|Myxococcales	28221|Deltaproteobacteria	M	Cell division protein FtsI penicillin-binding protein 2	pbp4	-	-	-	-	-	-	-	-	-	-	-	Transpeptidase
HKD2_k127_4401291_3	378806.STAUR_5842	3.6e-63	222.0	COG1435@1|root,COG1435@2|Bacteria,1PY2K@1224|Proteobacteria,42RJI@68525|delta/epsilon subdivisions,2WNKR@28221|Deltaproteobacteria,2YV2Y@29|Myxococcales	28221|Deltaproteobacteria	F	Thymidine kinase	tdk	-	2.7.1.21	ko:K00857	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01567,R02099,R08233	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	TK
HKD2_k127_4401291_0	448385.sce7969	1.804e-252	812.0	COG0823@1|root,COG4775@1|root,COG0823@2|Bacteria,COG4775@2|Bacteria,1R8QH@1224|Proteobacteria,42T02@68525|delta/epsilon subdivisions,2WPNU@28221|Deltaproteobacteria,2YUP3@29|Myxococcales	28221|Deltaproteobacteria	MU	WD40-like Beta Propeller Repeat	-	-	-	-	-	-	-	-	-	-	-	-	Bac_surface_Ag,PD40
HKD2_k127_4401291_5	485913.Krac_4700	1.427e-23	113.0	2DRZ7@1|root,33DSV@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4401912_0	502025.Hoch_3960	1.051e-31	138.0	COG1729@1|root,COG1729@2|Bacteria	2|Bacteria	S	protein trimerization	-	-	-	ko:K06894,ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	TPR_11,TPR_16,TPR_2,TPR_6,TPR_8,VWA_2
HKD2_k127_4405341_1	1192034.CAP_5635	3.309e-107	364.0	COG2304@1|root,COG2304@2|Bacteria,1NX8F@1224|Proteobacteria,430QD@68525|delta/epsilon subdivisions,2WVNR@28221|Deltaproteobacteria,2YW4W@29|Myxococcales	28221|Deltaproteobacteria	S	Aerotolerance regulator N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	BatA,VWA_2
HKD2_k127_4405341_0	1121920.AUAU01000004_gene735	3.398e-233	736.0	COG3404@1|root,COG3643@1|root,COG3404@2|Bacteria,COG3643@2|Bacteria,3Y3HP@57723|Acidobacteria	57723|Acidobacteria	E	TIGRFAM glutamate formiminotransferase	-	-	2.1.2.5,4.3.1.4	ko:K00603,ko:K13990	ko00340,ko00670,ko01100,map00340,map00670,map01100	-	R02287,R02302,R03189	RC00165,RC00221,RC00223,RC00688,RC00870	ko00000,ko00001,ko01000,ko03036,ko04147	-	-	-	FTCD,FTCD_C,FTCD_N
HKD2_k127_4405341_2	448385.sce0664	3.453e-72	246.0	COG0556@1|root,COG0556@2|Bacteria,1MUFK@1224|Proteobacteria,42MFA@68525|delta/epsilon subdivisions,2WJ20@28221|Deltaproteobacteria,2YU4B@29|Myxococcales	28221|Deltaproteobacteria	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	-	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
HKD2_k127_4405510_0	1254432.SCE1572_11780	4.008e-288	928.0	COG0457@1|root,COG0515@1|root,COG3899@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG3899@2|Bacteria,1QA6R@1224|Proteobacteria,438FC@68525|delta/epsilon subdivisions,2X3QC@28221|Deltaproteobacteria,2YWU9@29|Myxococcales	28221|Deltaproteobacteria	KLT	Family membership	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,Pkinase
HKD2_k127_4405510_1	1122604.JONR01000008_gene2252	1.588e-182	587.0	COG2010@1|root,COG2132@1|root,COG2010@2|Bacteria,COG2132@2|Bacteria,1MV74@1224|Proteobacteria,1RXZF@1236|Gammaproteobacteria,1X3IK@135614|Xanthomonadales	135614|Xanthomonadales	CQ	Multicopper oxidase	-	-	1.7.2.1	ko:K00368	ko00910,ko01120,map00910,map01120	M00529	R00783,R00785	RC00086	ko00000,ko00001,ko00002,ko01000	-	-	-	Cu-oxidase,Cu-oxidase_3,Cytochrome_CBB3
HKD2_k127_4405510_4	497964.CfE428DRAFT_3241	8.595e-62	222.0	COG1262@1|root,COG1262@2|Bacteria	2|Bacteria	T	PFAM Formylglycine-generating sulfatase enzyme	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase
HKD2_k127_4405510_7	1123377.AUIV01000005_gene1738	1.519e-31	139.0	COG1999@1|root,COG1999@2|Bacteria,1N5E3@1224|Proteobacteria,1SEFK@1236|Gammaproteobacteria,1X6YE@135614|Xanthomonadales	135614|Xanthomonadales	S	SCO1/SenC	-	-	-	ko:K07152	-	-	-	-	ko00000,ko03029	-	-	-	SCO1-SenC
HKD2_k127_4405510_5	937777.Deipe_0126	1.88e-61	224.0	COG2816@1|root,COG2816@2|Bacteria	2|Bacteria	L	NAD+ diphosphatase activity	nudC	GO:0003674,GO:0003824,GO:0004551,GO:0005488,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0030145,GO:0035529,GO:0043167,GO:0043169,GO:0046872,GO:0046914	1.3.7.1,3.6.1.22	ko:K03426,ko:K20449	ko00760,ko01100,ko01120,ko04146,map00760,map01100,map01120,map04146	-	R00103,R03004,R03164,R11104	RC00002,RC02422	ko00000,ko00001,ko01000	-	-	-	NUDIX,NUDIX-like,zf-NADH-PPase
HKD2_k127_4405510_3	383372.Rcas_0264	1.986e-62	233.0	COG5184@1|root,COG5184@2|Bacteria,2G8WU@200795|Chloroflexi,3765G@32061|Chloroflexia	32061|Chloroflexia	DZ	PFAM regulator of chromosome condensation, RCC1	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4405510_2	1242864.D187_009424	1.512e-88	313.0	COG3209@1|root,COG3209@2|Bacteria,1Q3W1@1224|Proteobacteria,439Q0@68525|delta/epsilon subdivisions,2X51Z@28221|Deltaproteobacteria,2Z002@29|Myxococcales	28221|Deltaproteobacteria	M	Ig-like domain from next to BRCA1 gene	-	-	-	-	-	-	-	-	-	-	-	-	N_BRCA1_IG
HKD2_k127_4405510_8	1172181.KB911711_gene2866	1.066e-22	100.0	2C19F@1|root,32TZS@2|Bacteria,2IQN6@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4405510_9	1121920.AUAU01000021_gene2521	6.573e-22	105.0	COG3809@1|root,COG3809@2|Bacteria,3Y803@57723|Acidobacteria	57723|Acidobacteria	S	Transcription factor zinc-finger	-	-	-	-	-	-	-	-	-	-	-	-	DZR,zf-TFIIB
HKD2_k127_4405510_6	204669.Acid345_0096	1.3e-33	132.0	COG0730@1|root,COG0730@2|Bacteria,3Y52Z@57723|Acidobacteria,2JJKT@204432|Acidobacteriia	204432|Acidobacteriia	S	Sulfite exporter TauE/SafE	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
HKD2_k127_4410123_6	1192034.CAP_4887	5.219e-26	107.0	2AIXE@1|root,319F2@2|Bacteria,1Q2IN@1224|Proteobacteria,4385F@68525|delta/epsilon subdivisions,2X3FF@28221|Deltaproteobacteria,2YVUW@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4410123_1	448385.sce8687	6.638e-98	328.0	COG2267@1|root,COG2267@2|Bacteria,1QX85@1224|Proteobacteria,42W1M@68525|delta/epsilon subdivisions,2WR6V@28221|Deltaproteobacteria,2YUZN@29|Myxococcales	28221|Deltaproteobacteria	I	alpha beta	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_4,Abhydrolase_6
HKD2_k127_4410123_3	1254432.SCE1572_39200	6.18e-78	269.0	COG5424@1|root,COG5424@2|Bacteria,1Q9R2@1224|Proteobacteria,434J3@68525|delta/epsilon subdivisions,2X8WX@28221|Deltaproteobacteria,2Z0SN@29|Myxococcales	28221|Deltaproteobacteria	H	Iron-containing redox enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Haem_oxygenas_2
HKD2_k127_4410123_9	483219.LILAB_14820	2.012e-08	59.0	COG1396@1|root,COG1917@1|root,COG1396@2|Bacteria,COG1917@2|Bacteria,1N34Y@1224|Proteobacteria,42TV3@68525|delta/epsilon subdivisions,2WQ5Z@28221|Deltaproteobacteria,2YUQ5@29|Myxococcales	28221|Deltaproteobacteria	K	Cro/C1-type HTH DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2,HTH_31
HKD2_k127_4410123_0	1254432.SCE1572_44155	2.429e-146	477.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,42M5F@68525|delta/epsilon subdivisions,2WKRR@28221|Deltaproteobacteria,2YUIY@29|Myxococcales	28221|Deltaproteobacteria	IQ	AMP-binding enzyme C-terminal domain	fadD4	-	-	ko:K18660,ko:K18661	ko00280,map00280	-	R03383	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C
HKD2_k127_4410123_7	1297742.A176_05761	3.474e-10	73.0	COG5640@1|root,COG5640@2|Bacteria,1NNT3@1224|Proteobacteria,4336R@68525|delta/epsilon subdivisions,2WXZ9@28221|Deltaproteobacteria,2YV5V@29|Myxococcales	28221|Deltaproteobacteria	O	Trypsin-like serine protease	-	-	-	-	-	-	-	-	-	-	-	-	Trypsin
HKD2_k127_4410123_2	1254432.SCE1572_13950	3.875e-81	276.0	COG0652@1|root,COG0652@2|Bacteria,1R9ZQ@1224|Proteobacteria,43AKE@68525|delta/epsilon subdivisions,2WMV2@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	-	-	5.2.1.8	ko:K03767	ko01503,ko04217,map01503,map04217	-	-	-	ko00000,ko00001,ko01000,ko03110,ko04147	-	-	-	Pro_isomerase
HKD2_k127_4410123_10	1127695.HMPREF9163_01643	1.913e-05	54.0	COG0526@1|root,COG0526@2|Bacteria,1VAPY@1239|Firmicutes,4H4YZ@909932|Negativicutes	909932|Negativicutes	CO	Periplasmic protein thiol disulfide oxidoreductase, DsbE subfamily	dsbE	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,Redoxin
HKD2_k127_4410123_8	404589.Anae109_2308	7.886e-10	59.0	28H8R@1|root,2Z7KJ@2|Bacteria,1Q390@1224|Proteobacteria,43905@68525|delta/epsilon subdivisions,2X457@28221|Deltaproteobacteria,2YYAC@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4415255_1	448385.sce3864	6.25e-79	273.0	COG1807@1|root,COG1807@2|Bacteria,1QX93@1224|Proteobacteria,43C25@68525|delta/epsilon subdivisions,2X7CQ@28221|Deltaproteobacteria,2YUUE@29|Myxococcales	28221|Deltaproteobacteria	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HKD2_k127_4415255_2	272134.KB731324_gene1777	3.5e-37	156.0	COG0350@1|root,COG0350@2|Bacteria,1G0MX@1117|Cyanobacteria,1HFC6@1150|Oscillatoriales	1117|Cyanobacteria	L	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain	-	-	2.1.1.63	ko:K00567,ko:K10778	-	-	-	-	ko00000,ko01000,ko03000,ko03400	-	-	-	Ada_Zn_binding,DNA_binding_1,HTH_18,Methyltransf_1N
HKD2_k127_4415255_0	1192034.CAP_8765	3.588e-139	457.0	COG0122@1|root,COG2169@1|root,COG0122@2|Bacteria,COG2169@2|Bacteria,1QTXM@1224|Proteobacteria,42N8C@68525|delta/epsilon subdivisions,2WM3N@28221|Deltaproteobacteria,2YUFY@29|Myxococcales	28221|Deltaproteobacteria	K	AlkA N-terminal domain	ada	-	3.2.2.21	ko:K13529,ko:K13530	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03000,ko03400	-	-	-	Ada_Zn_binding,AlkA_N,HTH_18,HhH-GPD
HKD2_k127_4420960_8	246197.MXAN_4231	3.298e-29	124.0	COG0665@1|root,COG0665@2|Bacteria,1MVIZ@1224|Proteobacteria,42REB@68525|delta/epsilon subdivisions,2WNWD@28221|Deltaproteobacteria,2YUH8@29|Myxococcales	28221|Deltaproteobacteria	C	FAD dependent oxidoreductase	thiO	-	1.4.3.19	ko:K03153	ko00730,ko01100,map00730,map01100	-	R07463	RC01788	ko00000,ko00001,ko01000	-	-	-	DAO
HKD2_k127_4420960_1	1049564.TevJSym_ad01620	7.778e-246	776.0	COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,1RNSZ@1236|Gammaproteobacteria,1J4UF@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	-	-	-	-	-	-	-	-	-	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU
HKD2_k127_4420960_10	522306.CAP2UW1_1221	9.661e-14	76.0	COG2841@1|root,COG2841@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF465)	-	-	-	ko:K09794	-	-	-	-	ko00000	-	-	-	DUF465
HKD2_k127_4420960_9	235985.BBPN01000040_gene354	1.718e-28	132.0	COG3511@1|root,COG3511@2|Bacteria,2GKPN@201174|Actinobacteria,2NKRD@228398|Streptacidiphilus	201174|Actinobacteria	M	Phosphoesterase family	-	-	3.1.4.3	ko:K01114	ko00562,ko00564,ko00565,ko01100,ko01110,ko02024,ko04919,map00562,map00564,map00565,map01100,map01110,map02024,map04919	-	R01312,R02027,R02052,R03332,R07381	RC00017,RC00425	ko00000,ko00001,ko01000,ko02042	-	-	-	Phosphoesterase
HKD2_k127_4420960_5	391625.PPSIR1_21559	1.77e-75	265.0	2ADHK@1|root,343DY@2|Bacteria,1P2K2@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4420960_2	1254432.SCE1572_22435	2.222e-154	505.0	COG0154@1|root,COG0154@2|Bacteria,1MW3Z@1224|Proteobacteria,42RYP@68525|delta/epsilon subdivisions,2WNDE@28221|Deltaproteobacteria,2YYGQ@29|Myxococcales	28221|Deltaproteobacteria	J	Belongs to the amidase family	-	-	3.5.1.99	ko:K19176	-	-	-	-	ko00000,ko01000	-	-	-	Amidase
HKD2_k127_4420960_4	1192034.CAP_7178	1.328e-86	299.0	2DHAX@1|root,32U8Z@2|Bacteria,1NVPN@1224|Proteobacteria,43DKP@68525|delta/epsilon subdivisions,2X8RV@28221|Deltaproteobacteria,2Z3NG@29|Myxococcales	28221|Deltaproteobacteria	S	Zinc finger domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4420960_6	221288.JH992901_gene3749	1.179e-74	264.0	COG0535@1|root,COG0535@2|Bacteria,1G2HH@1117|Cyanobacteria,1JIB3@1189|Stigonemataceae	1117|Cyanobacteria	S	4Fe-4S single cluster domain	-	-	-	ko:K06139	-	-	-	-	ko00000	-	-	-	Fer4_12,Radical_SAM,SPASM
HKD2_k127_4420960_3	886293.Sinac_3436	4.496e-91	318.0	COG3228@1|root,COG3228@2|Bacteria,2IZES@203682|Planctomycetes	203682|Planctomycetes	S	Belongs to the MtfA family	-	-	-	ko:K09933	-	-	-	-	ko00000,ko01002	-	-	-	Peptidase_M90,SEC-C
HKD2_k127_4420960_0	1095769.CAHF01000022_gene143	1.521e-260	818.0	COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,2VIY8@28216|Betaproteobacteria	28216|Betaproteobacteria	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
HKD2_k127_4420960_7	1122604.JONR01000022_gene629	4.989e-35	141.0	COG1309@1|root,COG1309@2|Bacteria,1RAF9@1224|Proteobacteria,1SHKH@1236|Gammaproteobacteria,1XAIW@135614|Xanthomonadales	135614|Xanthomonadales	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
HKD2_k127_4420965_0	448385.sce2235	4.542e-68	248.0	COG0515@1|root,COG0515@2|Bacteria	448385.sce2235|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4420965_1	485913.Krac_4700	1.987e-13	82.0	2DRZ7@1|root,33DSV@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4428857_3	997296.PB1_00360	6.939e-11	71.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	glgP	-	2.4.1.1,2.4.1.11	ko:K16153	ko00500,ko01100,ko01110,map00500,map01100,map01110	-	R00292,R02111	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT3,GT35	-	DUF3417,Glyco_trans_1_2,Glyco_transf_4,Glyco_transf_8,Glycogen_syn,Glycos_transf_1,Glycos_transf_2,Phosphorylase
HKD2_k127_4428857_1	251229.Chro_2241	3.486e-143	475.0	COG1132@1|root,COG1132@2|Bacteria,1G0C0@1117|Cyanobacteria,3VJIT@52604|Pleurocapsales	1117|Cyanobacteria	V	COGs COG1132 ABC-type multidrug transport system ATPase and permease components	-	-	-	ko:K06147,ko:K06148	-	-	-	-	ko00000,ko02000	3.A.1,3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_tran
HKD2_k127_4428857_0	1121920.AUAU01000006_gene322	1.888e-149	479.0	COG2513@1|root,COG2513@2|Bacteria,3Y400@57723|Acidobacteria	57723|Acidobacteria	G	Phosphoenolpyruvate phosphomutase	-	-	-	-	-	-	-	-	-	-	-	-	PEP_mutase
HKD2_k127_4428857_6	471852.Tcur_1362	0.0006041	51.0	COG2207@1|root,COG2207@2|Bacteria,2GK7Q@201174|Actinobacteria,4EGPW@85012|Streptosporangiales	201174|Actinobacteria	K	Cupin	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_6,HTH_18
HKD2_k127_4428857_5	1038860.AXAP01000006_gene6684	7.485e-06	59.0	COG4409@1|root,COG4409@2|Bacteria,1MVUD@1224|Proteobacteria,2TRQQ@28211|Alphaproteobacteria,3JRHA@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	exo-alpha-(2->6)-sialidase activity	-	-	-	-	-	-	-	-	-	-	-	-	BNR_2
HKD2_k127_4428857_2	1313172.YM304_31240	3.091e-61	216.0	COG0204@1|root,COG0204@2|Bacteria,2IDC7@201174|Actinobacteria	201174|Actinobacteria	I	Acyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acyltransferase
HKD2_k127_4428857_4	1206737.BAGF01000149_gene6033	1.918e-06	60.0	COG0265@1|root,COG0265@2|Bacteria,2GJ92@201174|Actinobacteria,4FZB2@85025|Nocardiaceae	201174|Actinobacteria	O	Colicin V production protein	cvpA	GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0009268,GO:0009405,GO:0009628,GO:0010447,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044419,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051704,GO:0071944	-	-	-	-	-	-	-	-	-	-	Colicin_V,Trypsin_2
HKD2_k127_4441447_0	1242864.D187_007142	5.127e-136	444.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJ8D@28221|Deltaproteobacteria,2YYD8@29|Myxococcales	28221|Deltaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
HKD2_k127_4441447_1	314278.NB231_04715	1.127e-114	383.0	COG1741@1|root,COG1741@2|Bacteria,1MWIP@1224|Proteobacteria,1RNVM@1236|Gammaproteobacteria,1WXMH@135613|Chromatiales	135613|Chromatiales	S	Belongs to the pirin family	-	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin,Pirin_C
HKD2_k127_4441447_2	240015.ACP_3077	4.904e-37	145.0	COG1846@1|root,COG1846@2|Bacteria,3Y82F@57723|Acidobacteria,2JN6R@204432|Acidobacteriia	204432|Acidobacteriia	K	Transcriptional regulator	-	-	-	ko:K15973	-	-	-	-	ko00000,ko03000	-	-	-	MarR,MarR_2
HKD2_k127_4441447_3	1237149.C900_03078	1.647e-34	138.0	COG4978@1|root,COG4978@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	GyrI-like
HKD2_k127_4449934_2	926566.Terro_3726	8.238e-32	141.0	COG3055@1|root,COG3055@2|Bacteria	2|Bacteria	G	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses	-	-	-	-	-	-	-	-	-	-	-	-	DUF1929,Kelch_1,Kelch_4,Kelch_6
HKD2_k127_4449934_3	448385.sce0785	0.000442	53.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	HYR,HtaA,Neocarzinostat
HKD2_k127_4449934_0	1267533.KB906745_gene56	2.3e-311	969.0	COG0021@1|root,COG0021@2|Bacteria,3Y38K@57723|Acidobacteria,2JHWX@204432|Acidobacteriia	204432|Acidobacteriia	G	Belongs to the transketolase family	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
HKD2_k127_4449934_1	272134.KB731324_gene931	3.756e-134	437.0	COG0364@1|root,COG0364@2|Bacteria,1G0K9@1117|Cyanobacteria,1H8E8@1150|Oscillatoriales	1117|Cyanobacteria	G	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone	zwf	-	1.1.1.363,1.1.1.49	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	M00004,M00006,M00008	R00835,R02736,R10907	RC00001,RC00066	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	G6PD_C,G6PD_N
HKD2_k127_4473975_2	1122609.AUGT01000020_gene1060	2.213e-27	126.0	COG2360@1|root,COG2360@2|Bacteria,2IFT7@201174|Actinobacteria,4DQD7@85009|Propionibacteriales	201174|Actinobacteria	O	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine	aat	-	2.3.2.6	ko:K00684	-	-	R03813,R11443,R11444	RC00055,RC00064	ko00000,ko01000	-	-	-	Leu_Phe_trans
HKD2_k127_4473975_1	1254432.SCE1572_03090	1.874e-37	156.0	COG1670@1|root,COG1670@2|Bacteria,1MVG4@1224|Proteobacteria,42XWG@68525|delta/epsilon subdivisions,2WT8J@28221|Deltaproteobacteria,2YV7I@29|Myxococcales	28221|Deltaproteobacteria	J	Acetyltransferase (GNAT) domain	rimJ	-	2.3.1.128	ko:K03790	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_3
HKD2_k127_4473975_0	365528.KB891209_gene2180	3.76e-62	219.0	COG0652@1|root,COG0652@2|Bacteria,2IFUE@201174|Actinobacteria,4ESIC@85013|Frankiales	201174|Actinobacteria	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	cypB	-	5.2.1.8	ko:K03767,ko:K03768	ko01503,ko04217,map01503,map04217	-	-	-	ko00000,ko00001,ko01000,ko03110,ko04147	-	-	-	Pro_isomerase
HKD2_k127_4474514_1	1380386.JIAW01000010_gene4149	4.316e-06	60.0	COG3693@1|root,COG3693@2|Bacteria,2GN8V@201174|Actinobacteria,237GJ@1762|Mycobacteriaceae	201174|Actinobacteria	G	Belongs to the glycosyl hydrolase 5 (cellulase A) family	-	-	-	-	-	-	-	-	-	-	-	-	Cellulase,Glyco_hydro_42
HKD2_k127_4476595_0	1254432.SCE1572_34470	1.757e-138	479.0	COG4775@1|root,COG4775@2|Bacteria,1Q2CZ@1224|Proteobacteria,437ZA@68525|delta/epsilon subdivisions,2X399@28221|Deltaproteobacteria,2YUX9@29|Myxococcales	28221|Deltaproteobacteria	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	-	-	-	-	-	-	-	-	-	-	-	-	Bac_surface_Ag
HKD2_k127_4476595_1	1501230.ET33_35695	2.594e-14	87.0	COG0457@1|root,COG0457@2|Bacteria,1U374@1239|Firmicutes,4ICYN@91061|Bacilli,26VYX@186822|Paenibacillaceae	91061|Bacilli	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_19
HKD2_k127_4490844_0	1288494.EBAPG3_2220	1.615e-212	666.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2VIP3@28216|Betaproteobacteria,372WX@32003|Nitrosomonadales	1224|Proteobacteria	F	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	acsA	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
HKD2_k127_4490844_2	216594.MMAR_3489	4.348e-124	425.0	COG1071@1|root,COG1071@2|Bacteria,2IBRC@201174|Actinobacteria,234F0@1762|Mycobacteriaceae	201174|Actinobacteria	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	pdhA	-	1.2.4.1	ko:K00161	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
HKD2_k127_4490844_1	330214.NIDE3853	5.352e-145	485.0	COG0022@1|root,COG0022@2|Bacteria	2|Bacteria	C	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor	pdhB	-	1.2.4.1,1.2.4.4	ko:K00162,ko:K11381	ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00036,M00307	R00014,R00209,R01699,R03270,R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00004,RC00027,RC00627,RC02742,RC02743,RC02744,RC02882,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh,Transket_pyr,Transketolase_C
HKD2_k127_4490844_3	1123247.AUIJ01000038_gene2920	4.202e-51	203.0	COG0508@1|root,COG0508@2|Bacteria,1MUGY@1224|Proteobacteria,2TUU4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	2-oxoacid dehydrogenases acyltransferase (catalytic domain)	-	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
HKD2_k127_450407_2	1192034.CAP_1747	5.495e-13	71.0	COG3170@1|root,COG3170@2|Bacteria,1QX3V@1224|Proteobacteria,43BWB@68525|delta/epsilon subdivisions,2X773@28221|Deltaproteobacteria,2YVT2@29|Myxococcales	28221|Deltaproteobacteria	NU	zinc-ribbon domain	-	-	-	-	-	-	-	-	-	-	-	-	zinc_ribbon_4
HKD2_k127_450407_1	1254432.SCE1572_46615	7.156e-64	242.0	COG1470@1|root,COG1470@2|Bacteria,1P6QQ@1224|Proteobacteria,4385T@68525|delta/epsilon subdivisions,2X3FM@28221|Deltaproteobacteria,2YVWE@29|Myxococcales	28221|Deltaproteobacteria	S	cell adhesion involved in biofilm formation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4504375_2	1278073.MYSTI_03333	3.4e-38	151.0	COG0204@1|root,COG0204@2|Bacteria,1PZS9@1224|Proteobacteria,434JR@68525|delta/epsilon subdivisions,2WYX1@28221|Deltaproteobacteria,2Z0U7@29|Myxococcales	28221|Deltaproteobacteria	I	Phosphate acyltransferases	-	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
HKD2_k127_4504375_1	1278073.MYSTI_04719	3.669e-46	175.0	COG2947@1|root,COG2947@2|Bacteria,1RHRU@1224|Proteobacteria	1224|Proteobacteria	S	Ubiquinol-cytochrome C reductase	MA20_25125	-	-	-	-	-	-	-	-	-	-	-	EVE
HKD2_k127_4504375_0	448385.sce1764	3.408e-123	401.0	COG1716@1|root,COG2199@1|root,COG1716@2|Bacteria,COG3706@2|Bacteria,1MZV7@1224|Proteobacteria,4302C@68525|delta/epsilon subdivisions,2WVBW@28221|Deltaproteobacteria,2YUSZ@29|Myxococcales	28221|Deltaproteobacteria	T	GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	FHA,GGDEF,Yop-YscD_cpl
HKD2_k127_4504375_4	1120968.AUBX01000012_gene2770	1.693e-12	72.0	COG4886@1|root,COG4886@2|Bacteria,4NKMV@976|Bacteroidetes,47XBF@768503|Cytophagia	976|Bacteroidetes	S	Leucine-rich repeat (LRR) protein	-	-	-	ko:K13730	ko05100,map05100	-	-	-	ko00000,ko00001	-	-	-	COR,LRR_4,Roc,TIR_2
HKD2_k127_4541563_1	215803.DB30_8496	8.392e-63	221.0	COG0518@1|root,COG0518@2|Bacteria,1Q3IW@1224|Proteobacteria,439BQ@68525|delta/epsilon subdivisions,2X4JR@28221|Deltaproteobacteria,2YZ5H@29|Myxococcales	28221|Deltaproteobacteria	F	GMP synthase (glutamine-hydrolyzing) activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4541563_0	215803.DB30_8497	5.719e-123	412.0	COG0189@1|root,COG0189@2|Bacteria,1PC9W@1224|Proteobacteria,438BJ@68525|delta/epsilon subdivisions,2X3KY@28221|Deltaproteobacteria,2YWGF@29|Myxococcales	28221|Deltaproteobacteria	HJ	ligase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4541563_2	1121438.JNJA01000018_gene3318	1.14e-52	191.0	COG0531@1|root,COG0531@2|Bacteria,1MXNJ@1224|Proteobacteria,42Q9Q@68525|delta/epsilon subdivisions,2WKCR@28221|Deltaproteobacteria,2MGIR@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	Amino acid permease	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2,PTS_EIIA_2
HKD2_k127_4546785_0	305900.GV64_19425	8.484e-139	456.0	COG2723@1|root,COG2723@2|Bacteria,1MWG6@1224|Proteobacteria,1RMM2@1236|Gammaproteobacteria,1XI8N@135619|Oceanospirillales	135619|Oceanospirillales	G	beta-glucosidase	-	-	3.2.1.21	ko:K05350	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_1
HKD2_k127_4546785_1	1411123.JQNH01000001_gene968	9.812e-81	277.0	COG1793@1|root,COG3285@1|root,COG1793@2|Bacteria,COG3285@2|Bacteria,1MVWY@1224|Proteobacteria,2TRSZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	DNA ligase	-	-	6.5.1.1	ko:K01971	ko03450,map03450	-	R00381	RC00005	ko00000,ko00001,ko01000,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,LigD_N
HKD2_k127_4570402_1	1071679.BG57_07830	1.637e-80	272.0	COG0282@1|root,COG0282@2|Bacteria,1MW61@1224|Proteobacteria,2VHRC@28216|Betaproteobacteria,1K1WI@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction	ackA	-	2.7.2.1	ko:K00925	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00315,R01353	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetate_kinase
HKD2_k127_4570402_0	1144275.COCOR_01446	9.302e-182	581.0	COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,42MRU@68525|delta/epsilon subdivisions,2WIQX@28221|Deltaproteobacteria,2YZUW@29|Myxococcales	28221|Deltaproteobacteria	MU	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
HKD2_k127_4570402_2	1144275.COCOR_01445	1.487e-67	249.0	COG0845@1|root,COG0845@2|Bacteria,1MUG6@1224|Proteobacteria,42NC1@68525|delta/epsilon subdivisions,2WMKG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Biotin-lipoyl like	-	-	-	ko:K01993	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
HKD2_k127_4598165_4	448385.sce4033	4.873e-68	263.0	2AJ10@1|root,319J4@2|Bacteria,1Q2X4@1224|Proteobacteria,438K5@68525|delta/epsilon subdivisions,2X3UQ@28221|Deltaproteobacteria,2YX5Z@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4598165_5	404589.Anae109_0329	7.869e-50	193.0	COG0515@1|root,COG0515@2|Bacteria,1MVEU@1224|Proteobacteria,4340I@68525|delta/epsilon subdivisions,2X4FB@28221|Deltaproteobacteria,2Z047@29|Myxococcales	28221|Deltaproteobacteria	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HKD2_k127_4598165_1	391625.PPSIR1_37504	2.932e-103	353.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	ko:K10941	ko02020,ko02025,ko05111,map02020,map02025,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_8,Sigma54_activat,TPR_12,Yop-YscD_cpl
HKD2_k127_4598165_10	1254432.SCE1572_04780	1.886e-20	103.0	COG4105@1|root,COG4105@2|Bacteria	2|Bacteria	S	cell envelope organization	bamD	-	-	ko:K05807,ko:K08309	-	-	-	-	ko00000,ko01000,ko01011,ko02000	1.B.33.1	GH23	-	YfiO
HKD2_k127_4598165_6	1192034.CAP_7281	7.322e-45	181.0	COG3757@1|root,COG3757@2|Bacteria,1N792@1224|Proteobacteria,432YH@68525|delta/epsilon subdivisions	1224|Proteobacteria	M	Glycosyl hydrolases family 25	yegX	-	-	ko:K07273	-	-	-	-	ko00000	-	-	-	Glyco_hydro_25
HKD2_k127_4598165_3	1246995.AFR_04305	6.607e-80	286.0	COG0739@1|root,COG0739@2|Bacteria,2I589@201174|Actinobacteria,4DK5V@85008|Micromonosporales	201174|Actinobacteria	M	Pkd domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4598165_7	1288494.EBAPG3_15870	6.114e-41	166.0	COG1388@1|root,COG2059@1|root,COG1388@2|Bacteria,COG2059@2|Bacteria,1MY1S@1224|Proteobacteria,2VZIM@28216|Betaproteobacteria,372XN@32003|Nitrosomonadales	28216|Betaproteobacteria	M	Domain of Unknown Function (DUF1259)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1529
HKD2_k127_4598165_2	448385.sce0947	6.141e-85	301.0	COG4251@1|root,COG4251@2|Bacteria,1N0FI@1224|Proteobacteria,438UR@68525|delta/epsilon subdivisions,2X9J0@28221|Deltaproteobacteria,2YXU1@29|Myxococcales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
HKD2_k127_4598165_8	404589.Anae109_0791	1.176e-26	114.0	COG1846@1|root,COG1846@2|Bacteria,1RKAV@1224|Proteobacteria,42VFQ@68525|delta/epsilon subdivisions,2WRWP@28221|Deltaproteobacteria,2YVC3@29|Myxococcales	28221|Deltaproteobacteria	K	helix_turn_helix multiple antibiotic resistance protein	marR	-	-	-	-	-	-	-	-	-	-	-	MarR_2
HKD2_k127_4598165_9	1192034.CAP_3782	1.064e-22	104.0	COG2885@1|root,COG2885@2|Bacteria,1QAG8@1224|Proteobacteria,4352E@68525|delta/epsilon subdivisions,2WZDB@28221|Deltaproteobacteria,2Z1W3@29|Myxococcales	28221|Deltaproteobacteria	M	Belongs to the ompA family	-	-	-	-	-	-	-	-	-	-	-	-	OmpA
HKD2_k127_4598165_0	1278073.MYSTI_02776	4.671e-126	420.0	COG0745@1|root,COG0784@1|root,COG4191@1|root,COG0745@2|Bacteria,COG0784@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42PZ5@68525|delta/epsilon subdivisions,2WM5Q@28221|Deltaproteobacteria,2Z2WF@29|Myxococcales	28221|Deltaproteobacteria	T	PAS fold	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_4,PAS_8,PAS_9,Response_reg
HKD2_k127_4621397_4	338969.Rfer_1713	1.388e-31	143.0	2DBW6@1|root,2ZBEP@2|Bacteria,1QZ6S@1224|Proteobacteria	1224|Proteobacteria	C	TIGRFAM decaheme c-type cytochrome, OmcA MtrC family	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4621397_5	938709.AUSH02000020_gene1993	9.987e-27	128.0	COG3209@1|root,COG4886@1|root,COG5295@1|root,COG3209@2|Bacteria,COG4886@2|Bacteria,COG5295@2|Bacteria,4NF3S@976|Bacteroidetes	976|Bacteroidetes	UW	COG3209 Rhs family protein	-	-	-	-	-	-	-	-	-	-	-	-	Collagen,Peptidase_S74
HKD2_k127_4621397_3	404589.Anae109_1823	1.848e-34	149.0	COG0484@1|root,COG0484@2|Bacteria,1QYGD@1224|Proteobacteria,43CCI@68525|delta/epsilon subdivisions,2X7NG@28221|Deltaproteobacteria,2Z1CZ@29|Myxococcales	28221|Deltaproteobacteria	C	TIGRFAM cytochrome C family protein	-	-	-	-	-	-	-	-	-	-	-	-	GSu_C4xC__C2xCH
HKD2_k127_4621397_1	502025.Hoch_6280	8.798e-104	368.0	COG3005@1|root,COG3005@2|Bacteria,1R03H@1224|Proteobacteria,43CQK@68525|delta/epsilon subdivisions,2X7Y1@28221|Deltaproteobacteria,2Z1GR@29|Myxococcales	28221|Deltaproteobacteria	C	Cytochrome c7 and related cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C7
HKD2_k127_4621397_0	502025.Hoch_6275	3.701e-147	492.0	COG3303@1|root,COG3303@2|Bacteria,1NT38@1224|Proteobacteria,43CCP@68525|delta/epsilon subdivisions,2X7NK@28221|Deltaproteobacteria,2YZY2@29|Myxococcales	28221|Deltaproteobacteria	C	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4621397_7	247634.GPB2148_391	5.028e-09	66.0	COG2353@1|root,COG2353@2|Bacteria,1MZDI@1224|Proteobacteria,1S9EZ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Belongs to the UPF0312 family	-	-	-	-	-	-	-	-	-	-	-	-	YceI
HKD2_k127_4621397_6	1191523.MROS_1186	3.659e-24	107.0	COG3005@1|root,COG3005@2|Bacteria	2|Bacteria	C	denitrification pathway	-	GO:0003674,GO:0003824,GO:0005575,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0022900,GO:0031224,GO:0044237,GO:0044425,GO:0045333,GO:0055114	-	ko:K15876	ko00910,ko01120,map00910,map01120	M00530	R05712	RC00176	ko00000,ko00001,ko00002	-	-	-	Cytochrom_NNT,Cytochrom_c3_2
HKD2_k127_463412_3	1449346.JQMO01000003_gene4028	1.794e-07	61.0	COG2197@1|root,COG2197@2|Bacteria,2GJ5I@201174|Actinobacteria,2M0SN@2063|Kitasatospora	201174|Actinobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HKD2_k127_463412_1	290397.Adeh_4240	1.295e-75	273.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2YU4M@29|Myxococcales	28221|Deltaproteobacteria	T	Bacterial regulatory protein, Fis family	sasR	-	-	ko:K07713	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD2_k127_463412_2	1487953.JMKF01000028_gene1253	1.076e-10	74.0	COG5001@1|root,COG5001@2|Bacteria,1G0SY@1117|Cyanobacteria,1H9JN@1150|Oscillatoriales	1117|Cyanobacteria	T	Putative diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,FHA,GAF,GGDEF,PAS_3,PAS_9,Response_reg
HKD2_k127_463412_0	448385.sce1108	1.759e-192	607.0	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,42MMK@68525|delta/epsilon subdivisions,2WJC1@28221|Deltaproteobacteria,2YUAB@29|Myxococcales	28221|Deltaproteobacteria	S	ABC transporter	yjjK	-	3.6.3.25	ko:K06020	-	-	-	-	ko00000,ko01000	-	-	-	ABC_tran,ABC_tran_Xtn
HKD2_k127_4679759_14	1192034.CAP_3532	3.228e-38	145.0	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,42M2A@68525|delta/epsilon subdivisions,2WJ41@28221|Deltaproteobacteria,2YUJJ@29|Myxococcales	28221|Deltaproteobacteria	S	ABC transporter, ATP-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,ABC_tran_Xtn
HKD2_k127_4679759_2	448385.sce0414	1.018e-116	383.0	COG0413@1|root,COG0413@2|Bacteria,1MU3B@1224|Proteobacteria,42MES@68525|delta/epsilon subdivisions,2WIQK@28221|Deltaproteobacteria,2YU2N@29|Myxococcales	28221|Deltaproteobacteria	H	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate	panB	-	2.1.2.11	ko:K00606	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R01226	RC00022,RC00200	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_transf
HKD2_k127_4679759_19	1254432.SCE1572_22585	1.119e-26	114.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	qcrC	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	ko:K00406,ko:K03889	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00151,M00156	-	-	ko00000,ko00001,ko00002	3.D.4.3	-	-	Cytochrome_CBB3
HKD2_k127_4679759_1	502025.Hoch_3956	4.738e-141	466.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2X816@28221|Deltaproteobacteria,2Z3J5@29|Myxococcales	28221|Deltaproteobacteria	K	sigma54 specific, transcriptional regulator, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	Sigma54_activat,Yop-YscD_cpl
HKD2_k127_4679759_17	502025.Hoch_2401	1.819e-32	143.0	2DYJ3@1|root,34A1W@2|Bacteria,1PDJB@1224|Proteobacteria,435GY@68525|delta/epsilon subdivisions,2X99N@28221|Deltaproteobacteria,2Z2SE@29|Myxococcales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF3570)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3570
HKD2_k127_4679759_23	517418.Ctha_2109	7.964e-09	66.0	2E3QA@1|root,32YN8@2|Bacteria,1FFJG@1090|Chlorobi	1090|Chlorobi	M	Domain of unknown function (DUF4266)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4266
HKD2_k127_4679759_8	378806.STAUR_7185	2.968e-54	203.0	COG1073@1|root,COG1073@2|Bacteria,1QX68@1224|Proteobacteria,43BYU@68525|delta/epsilon subdivisions,2X79P@28221|Deltaproteobacteria,2YW41@29|Myxococcales	28221|Deltaproteobacteria	S	alpha beta	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4679759_0	1254432.SCE1572_46485	9.743e-287	899.0	COG1032@1|root,COG1032@2|Bacteria,1MUG3@1224|Proteobacteria,42N0P@68525|delta/epsilon subdivisions,2WJCQ@28221|Deltaproteobacteria,2YU1P@29|Myxococcales	28221|Deltaproteobacteria	C	UPF0313 protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF3362,Radical_SAM,Radical_SAM_N
HKD2_k127_4679759_9	290397.Adeh_0078	1.218e-49	189.0	2A9VF@1|root,30Z3B@2|Bacteria,1PKZS@1224|Proteobacteria,435JG@68525|delta/epsilon subdivisions,2WZXJ@28221|Deltaproteobacteria,2Z0YG@29|Myxococcales	290397.Adeh_0078|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4679759_10	936455.KI421499_gene2267	1.935e-47	177.0	COG1309@1|root,COG1309@2|Bacteria,1R8KS@1224|Proteobacteria,2TSYV@28211|Alphaproteobacteria,3JURE@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
HKD2_k127_4679759_3	316274.Haur_5257	1.997e-99	343.0	COG2124@1|root,COG2124@2|Bacteria,2G623@200795|Chloroflexi,376IV@32061|Chloroflexia	200795|Chloroflexi	C	PFAM cytochrome P450	-	-	-	-	-	-	-	-	-	-	-	-	p450
HKD2_k127_4679759_13	1254432.SCE1572_44005	1.333e-43	181.0	COG0218@1|root,COG0218@2|Bacteria,1MY3Z@1224|Proteobacteria,42RJR@68525|delta/epsilon subdivisions,2WMK3@28221|Deltaproteobacteria,2YVG8@29|Myxococcales	28221|Deltaproteobacteria	D	Necessary for normal cell division and for the maintenance of normal septation	engB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K03978	-	-	-	-	ko00000,ko03036	-	-	-	MMR_HSR1
HKD2_k127_4679759_5	269799.Gmet_2400	7.212e-83	299.0	COG0728@1|root,COG0728@2|Bacteria,1MUH0@1224|Proteobacteria,42M28@68525|delta/epsilon subdivisions,2WJPF@28221|Deltaproteobacteria,43TDN@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane	murJ	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
HKD2_k127_4679759_15	1254432.SCE1572_44010	4.101e-38	155.0	COG3536@1|root,COG3536@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF971)	-	-	-	ko:K03593	-	-	-	-	ko00000,ko03029,ko03036	-	-	-	DUF971
HKD2_k127_4679759_16	1242864.D187_010047	1.217e-34	151.0	COG0524@1|root,COG0524@2|Bacteria,1MX38@1224|Proteobacteria,439E0@68525|delta/epsilon subdivisions,2X4NZ@28221|Deltaproteobacteria,2YZBR@29|Myxococcales	28221|Deltaproteobacteria	G	pfkB family carbohydrate kinase	-	-	2.7.1.4	ko:K00847	ko00051,ko00500,ko00520,ko01100,map00051,map00500,map00520,map01100	-	R00760,R00867,R03920	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
HKD2_k127_4679759_11	1192034.CAP_7143	4.964e-46	176.0	COG1381@1|root,COG1381@2|Bacteria,1RIBW@1224|Proteobacteria,42PUE@68525|delta/epsilon subdivisions,2WK4W@28221|Deltaproteobacteria,2YVXU@29|Myxococcales	28221|Deltaproteobacteria	L	Involved in DNA repair and RecF pathway recombination	recO	-	-	ko:K03584	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecO_C,RecO_N
HKD2_k127_4679759_12	1254432.SCE1572_10575	8.038e-44	164.0	COG1426@1|root,COG1426@2|Bacteria,1NIQS@1224|Proteobacteria,4387Z@68525|delta/epsilon subdivisions,2X3HR@28221|Deltaproteobacteria,2YW5H@29|Myxococcales	28221|Deltaproteobacteria	S	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_25
HKD2_k127_4679759_7	448385.sce1677	1.967e-60	220.0	COG0457@1|root,COG0457@2|Bacteria,1MZGK@1224|Proteobacteria,42US4@68525|delta/epsilon subdivisions,2X72T@28221|Deltaproteobacteria,2YVP7@29|Myxococcales	28221|Deltaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_11,TPR_16,TPR_2,TPR_6,TPR_8
HKD2_k127_4679759_6	1254432.SCE1572_10565	2.745e-72	257.0	COG0664@1|root,COG0664@2|Bacteria,1NHNS@1224|Proteobacteria,42X3Y@68525|delta/epsilon subdivisions,2WT4M@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	cyclic nucleotide-binding	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Crp_2,cNMP_binding
HKD2_k127_4679759_4	448385.sce2824	1.82e-86	294.0	COG0131@1|root,COG0131@2|Bacteria,1MWBS@1224|Proteobacteria,42NIV@68525|delta/epsilon subdivisions,2WNA4@28221|Deltaproteobacteria,2YV6W@29|Myxococcales	28221|Deltaproteobacteria	E	Imidazoleglycerol-phosphate dehydratase	hisB	GO:0000105,GO:0003674,GO:0003824,GO:0004424,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.2.1.19	ko:K01693	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R03457	RC00932	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPD
HKD2_k127_4679759_18	1254432.SCE1572_00790	5.88e-27	119.0	COG3391@1|root,COG3391@2|Bacteria,1Q2JN@1224|Proteobacteria,4386H@68525|delta/epsilon subdivisions,2X9ZH@28221|Deltaproteobacteria,2YVZH@29|Myxococcales	28221|Deltaproteobacteria	S	Beta-L-arabinofuranosidase, GH127	-	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3,Stig1
HKD2_k127_4695922_0	448385.sce1269	4.474e-62	219.0	COG0454@1|root,COG3467@1|root,COG0454@2|Bacteria,COG3467@2|Bacteria,1NEP5@1224|Proteobacteria,42TH0@68525|delta/epsilon subdivisions,2X81R@28221|Deltaproteobacteria,2YZCR@29|Myxococcales	28221|Deltaproteobacteria	K	Pyridoxamine 5'-phosphate oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Pyridox_ox_2
HKD2_k127_4722906_3	448385.sce6471	2.863e-17	85.0	COG0278@1|root,COG0316@1|root,COG0607@1|root,COG0278@2|Bacteria,COG0316@2|Bacteria,COG0607@2|Bacteria,1MZ4V@1224|Proteobacteria,43154@68525|delta/epsilon subdivisions,2WWCI@28221|Deltaproteobacteria,2YVCT@29|Myxococcales	28221|Deltaproteobacteria	C	Belongs to the glutaredoxin family. Monothiol subfamily	-	-	-	ko:K07390	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Glutaredoxin,Rhodanese
HKD2_k127_4722906_4	1192034.CAP_8916	4.019e-12	76.0	2A4QA@1|root,30TBI@2|Bacteria,1PD3P@1224|Proteobacteria,43E58@68525|delta/epsilon subdivisions,2WZRS@28221|Deltaproteobacteria,2Z2M3@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4722906_1	1195236.CTER_0752	4.5e-46	185.0	COG0697@1|root,COG0697@2|Bacteria,1V1H0@1239|Firmicutes,24BBW@186801|Clostridia,3WKBH@541000|Ruminococcaceae	186801|Clostridia	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HKD2_k127_4722906_0	448385.sce0353	2.6e-112	376.0	COG0515@1|root,COG0515@2|Bacteria,1Q38J@1224|Proteobacteria,438ZJ@68525|delta/epsilon subdivisions,2X44T@28221|Deltaproteobacteria,2YY98@29|Myxococcales	28221|Deltaproteobacteria	KLT	Protein kinase domain	masK	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HKD2_k127_4722906_2	502025.Hoch_0069	9.155e-40	151.0	COG0639@1|root,COG4103@1|root,COG0639@2|Bacteria,COG4103@2|Bacteria,1NJ9V@1224|Proteobacteria,438VE@68525|delta/epsilon subdivisions,2X417@28221|Deltaproteobacteria,2YXWH@29|Myxococcales	28221|Deltaproteobacteria	T	Protein phosphatase 2A homologues, catalytic domain.	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
HKD2_k127_4774471_0	448385.sce_pseudo_02	0.0	1632.0	COG1413@1|root,COG2319@1|root,COG1413@2|Bacteria,COG2319@2|Bacteria,1NW2Z@1224|Proteobacteria,437V3@68525|delta/epsilon subdivisions,2X34K@28221|Deltaproteobacteria,2YU8J@29|Myxococcales	28221|Deltaproteobacteria	C	WD domain- G-beta repeat PBS lyase HEAT-like	-	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	HEAT_2,WD40
HKD2_k127_4774471_1	448385.sce1916	5.359e-283	899.0	COG0272@1|root,COG0272@2|Bacteria,1MYA4@1224|Proteobacteria,437UZ@68525|delta/epsilon subdivisions,2X34G@28221|Deltaproteobacteria,2YU7N@29|Myxococcales	28221|Deltaproteobacteria	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4774471_8	1192034.CAP_7959	2.951e-27	122.0	COG3831@1|root,COG3831@2|Bacteria,1QX5X@1224|Proteobacteria,43BYH@68525|delta/epsilon subdivisions,2X79D@28221|Deltaproteobacteria,2Z3EB@29|Myxococcales	28221|Deltaproteobacteria	S	Proposed nucleic acid binding domain	-	-	-	-	-	-	-	-	-	-	-	-	WGR
HKD2_k127_4774471_3	1254432.SCE1572_01535	1.717e-92	325.0	COG3384@1|root,COG3384@2|Bacteria,1MXJZ@1224|Proteobacteria,42Q1N@68525|delta/epsilon subdivisions,2WK3A@28221|Deltaproteobacteria,2Z377@29|Myxococcales	28221|Deltaproteobacteria	S	Catalytic LigB subunit of aromatic ring-opening dioxygenase	ygiD	-	-	ko:K15777	ko00965,map00965	-	R08836	RC00387	ko00000,ko00001,ko01000	-	-	-	LigB
HKD2_k127_4774471_9	1268237.G114_07445	1.278e-17	96.0	COG1366@1|root,COG1366@2|Bacteria,1MVPW@1224|Proteobacteria,1S26Y@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Anti-anti-sigma regulatory factor (Antagonist of anti-sigma factor)	rsbR	-	-	ko:K17763	-	-	-	-	ko00000,ko03021	-	-	-	Protoglobin,RsbRD_N,STAS
HKD2_k127_4774471_7	1299327.I546_3346	5.829e-33	144.0	COG0745@1|root,COG5002@1|root,COG0745@2|Bacteria,COG5002@2|Bacteria,2I2TP@201174|Actinobacteria,23FFT@1762|Mycobacteriaceae	201174|Actinobacteria	T	PAS domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF3365,HATPase_c,HisKA,HisKA_3,PAS_4,Response_reg
HKD2_k127_4774471_6	1121920.AUAU01000016_gene1287	1.392e-43	165.0	COG1633@1|root,COG1633@2|Bacteria,3Y925@57723|Acidobacteria	57723|Acidobacteria	S	Rubrerythrin	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
HKD2_k127_4774471_4	1379698.RBG1_1C00001G0031	1.109e-91	335.0	COG1007@1|root,COG1007@2|Bacteria,2NNMY@2323|unclassified Bacteria	2|Bacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoN	GO:0003674,GO:0003824,GO:0003954,GO:0008137,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114	1.6.5.3	ko:K00343,ko:K05573	ko00190,ko01100,map00190,map01100	M00144,M00145	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	iJN678.ndhB	Proton_antipo_M
HKD2_k127_4774471_2	1379698.RBG1_1C00001G0030	4.983e-158	528.0	COG1008@1|root,COG1008@2|Bacteria,2NQKN@2323|unclassified Bacteria	2|Bacteria	C	Proton-conducting membrane transporter	ndhD	-	1.6.5.3	ko:K00342,ko:K05575	ko00190,ko01100,map00190,map01100	M00144,M00145	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	iJN678.ndhD2	Oxidored_q5_N,Proton_antipo_M
HKD2_k127_4774471_5	1117108.PAALTS15_07114	3.289e-67	241.0	COG1009@1|root,COG1009@2|Bacteria,1TQW4@1239|Firmicutes,4H9YR@91061|Bacilli,26SE0@186822|Paenibacillaceae	91061|Bacilli	CP	Subunit A of antiporter complex involved in resistance to high concentrations of Na , K , Li and or alkali	nuoL	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_C,Proton_antipo_M,Proton_antipo_N
HKD2_k127_477711_3	313612.L8106_23246	9.683e-36	146.0	COG1226@1|root,COG1226@2|Bacteria,1G2MJ@1117|Cyanobacteria,1H8TX@1150|Oscillatoriales	1117|Cyanobacteria	P	k transport	-	-	-	ko:K10716	-	-	-	-	ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	Ion_trans,TrkA_N
HKD2_k127_477711_2	1254432.SCE1572_37345	7.997e-47	173.0	COG0764@1|root,COG0764@2|Bacteria,1QSTA@1224|Proteobacteria,4355J@68525|delta/epsilon subdivisions,2X9PY@28221|Deltaproteobacteria,2Z23M@29|Myxococcales	28221|Deltaproteobacteria	I	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_477711_1	204669.Acid345_2095	1.383e-79	279.0	COG0412@1|root,COG0412@2|Bacteria,3Y4CQ@57723|Acidobacteria,2JJ5E@204432|Acidobacteriia	204432|Acidobacteriia	Q	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_477711_4	1005048.CFU_0375	8.653e-27	128.0	COG3064@1|root,COG3064@2|Bacteria,1N9GV@1224|Proteobacteria,2W0MW@28216|Betaproteobacteria	28216|Betaproteobacteria	M	YXWGXW repeat (2 copies)	-	-	-	-	-	-	-	-	-	-	-	-	YXWGXW
HKD2_k127_477711_0	448385.sce5467	2.544e-166	535.0	COG1032@1|root,COG1032@2|Bacteria,1MY2Y@1224|Proteobacteria,42MCH@68525|delta/epsilon subdivisions,2WJPZ@28221|Deltaproteobacteria,2Z39Q@29|Myxococcales	28221|Deltaproteobacteria	C	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,DUF4070,Radical_SAM
HKD2_k127_4784271_0	1192034.CAP_0190	2.552e-111	389.0	COG1501@1|root,COG1501@2|Bacteria,1MWNJ@1224|Proteobacteria	1224|Proteobacteria	G	Belongs to the glycosyl hydrolase 31 family	yihQ	GO:0003674,GO:0003824,GO:0006066,GO:0006082,GO:0006790,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016054,GO:0016787,GO:0016798,GO:0019637,GO:0034308,GO:0042180,GO:0044237,GO:0044248,GO:0044273,GO:0044281,GO:0044282,GO:0061720,GO:0071704,GO:1901135,GO:1901136,GO:1901575,GO:1901615,GO:1902776,GO:1902777,GO:1990929	3.2.1.177,3.2.1.199	ko:K01811,ko:K15922	-	-	R00802,R11543	RC00028,RC00059,RC00077,RC00451	ko00000,ko01000	-	GH31	-	Glyco_hydro_31
HKD2_k127_4784271_1	246197.MXAN_2255	1.762e-45	171.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria	1224|Proteobacteria	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_12,zf-HC2
HKD2_k127_4789674_0	448385.sce2420	6.632e-185	582.0	COG0443@1|root,COG0443@2|Bacteria,1MVEN@1224|Proteobacteria,42M64@68525|delta/epsilon subdivisions,2WIWS@28221|Deltaproteobacteria,2YTUT@29|Myxococcales	28221|Deltaproteobacteria	O	heat shock protein 70	-	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
HKD2_k127_4789674_4	1254432.SCE1572_14585	1.801e-68	251.0	COG0484@1|root,COG0484@2|Bacteria,1R0C7@1224|Proteobacteria,43CUM@68525|delta/epsilon subdivisions,2X82A@28221|Deltaproteobacteria,2Z3JM@29|Myxococcales	28221|Deltaproteobacteria	O	DnaJ molecular chaperone homology domain	-	-	-	-	-	-	-	-	-	-	-	-	DnaJ
HKD2_k127_4789674_1	1254432.SCE1572_15325	1.991e-97	341.0	COG0741@1|root,COG0741@2|Bacteria	2|Bacteria	M	lytic transglycosylase activity	-	-	-	-	-	-	-	-	-	-	-	-	CHAP,Peptidase_M23,SLT,SLT_2
HKD2_k127_4789674_5	1449347.JQLN01000001_gene163	3.835e-63	237.0	COG3511@1|root,COG5563@1|root,COG3511@2|Bacteria,COG5563@2|Bacteria,2GKPN@201174|Actinobacteria	201174|Actinobacteria	M	phospholipase C	-	-	3.1.4.3	ko:K01114	ko00562,ko00564,ko00565,ko01100,ko01110,ko02024,ko04919,map00562,map00564,map00565,map01100,map01110,map02024,map04919	-	R01312,R02027,R02052,R03332,R07381	RC00017,RC00425	ko00000,ko00001,ko01000,ko02042	-	-	-	Phosphoesterase
HKD2_k127_4789674_3	1254432.SCE1572_29965	2.418e-70	249.0	COG1073@1|root,COG1073@2|Bacteria,1MZUA@1224|Proteobacteria,431FI@68525|delta/epsilon subdivisions,2WX1E@28221|Deltaproteobacteria,2YV8K@29|Myxococcales	28221|Deltaproteobacteria	S	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
HKD2_k127_4789674_2	448385.sce3214	1.326e-76	261.0	COG1309@1|root,COG1309@2|Bacteria,1R6RX@1224|Proteobacteria,42T50@68525|delta/epsilon subdivisions,2WPVV@28221|Deltaproteobacteria,2YUY1@29|Myxococcales	28221|Deltaproteobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	ko:K16137	-	-	-	-	ko00000,ko03000	-	-	-	TetR_C_13,TetR_N
HKD2_k127_4801266_7	1123508.JH636456_gene127	2.12e-39	151.0	COG3467@1|root,COG3467@2|Bacteria	2|Bacteria	T	pyridoxamine 5'-phosphate	-	-	-	ko:K07005	-	-	-	-	ko00000	-	-	-	Putative_PNPOx,Pyridox_ox_2
HKD2_k127_4801266_6	1121920.AUAU01000018_gene1786	4.977e-48	183.0	COG0508@1|root,COG0508@2|Bacteria	2|Bacteria	C	S-acyltransferase activity	-	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh
HKD2_k127_4801266_3	525904.Tter_0222	4.115e-107	361.0	COG0517@1|root,COG1994@1|root,COG0517@2|Bacteria,COG1994@2|Bacteria,2NPE1@2323|unclassified Bacteria	2|Bacteria	S	Peptidase family M50	rip3	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	ko:K06212,ko:K06402	-	-	-	-	ko00000,ko01000,ko01002,ko02000	1.A.16.1.1,1.A.16.1.3	-	-	CBS,Form_Nir_trans,Peptidase_M50
HKD2_k127_4801266_0	518766.Rmar_1698	1.044e-227	732.0	COG0466@1|root,COG0466@2|Bacteria,4NE1G@976|Bacteroidetes,1FJX3@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	O	Found in ATP-dependent protease La (LON)	lon	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
HKD2_k127_4801266_5	1122223.KB890687_gene2578	2.187e-60	236.0	COG1926@1|root,COG1926@2|Bacteria,1WKAM@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Phosphoribosyl transferase domain	-	-	-	ko:K07100	-	-	-	-	ko00000	-	-	-	Pribosyltran
HKD2_k127_4801266_4	1343740.M271_07555	6.457e-66	237.0	COG0412@1|root,COG0412@2|Bacteria,2I37P@201174|Actinobacteria	201174|Actinobacteria	Q	dienelactone hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	DLH
HKD2_k127_4801266_9	1123070.KB899255_gene1404	6.718e-14	83.0	COG5361@1|root,COG5361@2|Bacteria,46VNX@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Neurotransmitter-gated ion-channel ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Neur_chan_LBD,Neur_chan_memb
HKD2_k127_4801266_2	391625.PPSIR1_39645	7.483e-112	375.0	COG1793@1|root,COG1793@2|Bacteria,1MYI2@1224|Proteobacteria	1224|Proteobacteria	L	DNA ligase	-	-	6.5.1.1	ko:K01971	ko03450,map03450	-	R00381	RC00005	ko00000,ko00001,ko01000,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,DNA_primase_S
HKD2_k127_4801266_1	1254432.SCE1572_50885	6.021e-218	722.0	COG0515@1|root,COG2909@1|root,COG0515@2|Bacteria,COG2909@2|Bacteria,1QA6R@1224|Proteobacteria,4393M@68525|delta/epsilon subdivisions,2X49J@28221|Deltaproteobacteria,2YYJG@29|Myxococcales	28221|Deltaproteobacteria	KLT	Family membership	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,Pkinase
HKD2_k127_4801266_8	403833.Pmob_0187	1.907e-16	87.0	COG1259@1|root,COG1259@2|Bacteria,2GD3Y@200918|Thermotogae	200918|Thermotogae	S	PFAM Uncharacterised ACR, COG1259	-	-	-	ko:K08999	-	-	-	-	ko00000	-	-	-	DNase-RNase
HKD2_k127_482809_2	1192034.CAP_8112	3.088e-08	57.0	COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,42NI4@68525|delta/epsilon subdivisions,2WKRT@28221|Deltaproteobacteria,2YZVX@29|Myxococcales	28221|Deltaproteobacteria	Q	ABC transporter	-	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran,GGDEF
HKD2_k127_482809_1	404589.Anae109_0748	6.244e-29	125.0	COG4669@1|root,COG4669@2|Bacteria,1N69F@1224|Proteobacteria,42T6F@68525|delta/epsilon subdivisions,2WPNY@28221|Deltaproteobacteria	28221|Deltaproteobacteria	U	Secretory protein of YscJ/FliF family	nolT	-	-	ko:K03222	ko03070,map03070	M00332,M00542,M00660	-	-	ko00000,ko00001,ko00002,ko02044	3.A.6.1,3.A.6.3	-	-	YscJ_FliF
HKD2_k127_482809_0	448385.sce2990	5.62e-157	520.0	COG0553@1|root,COG4715@1|root,COG0553@2|Bacteria,COG4715@2|Bacteria,1MV6M@1224|Proteobacteria,42M5P@68525|delta/epsilon subdivisions,2WIW8@28221|Deltaproteobacteria,2YU7C@29|Myxococcales	28221|Deltaproteobacteria	KL	helicase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Helicase_C,SNF2_N,SNF2_assoc,SWIM
HKD2_k127_48426_4	1192034.CAP_2703	4.047e-41	156.0	COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,42MHD@68525|delta/epsilon subdivisions,2WTUX@28221|Deltaproteobacteria,2YTTM@29|Myxococcales	28221|Deltaproteobacteria	M	Belongs to the peptidase S41A family	-	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_S41
HKD2_k127_48426_5	748658.KB907318_gene1029	6.737e-28	132.0	COG0754@1|root,COG0754@2|Bacteria	2|Bacteria	E	glutathionylspermidine amidase activity	gsp	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008884,GO:0008885,GO:0016787,GO:0016810,GO:0016811,GO:0016874,GO:0016879,GO:0016880,GO:0044424,GO:0044444,GO:0044464	3.5.1.78,6.3.1.8	ko:K01460	ko00480,ko01100,map00480,map01100	-	R01917,R01918	RC00090,RC00096	ko00000,ko00001,ko01000	-	-	iECIAI39_1322.ECIAI39_3484	CHAP,GSP_synth
HKD2_k127_48426_7	47763.JNZA01000002_gene3477	1.455e-12	81.0	COG3858@1|root,COG3858@2|Bacteria,2HZ7I@201174|Actinobacteria	201174|Actinobacteria	S	Glycosyl hydrolases family 18	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_18
HKD2_k127_48426_1	448385.sce4537	2.076e-79	289.0	COG0500@1|root,COG2226@2|Bacteria,1RASQ@1224|Proteobacteria,42QTY@68525|delta/epsilon subdivisions,2WMN2@28221|Deltaproteobacteria,2YWX8@29|Myxococcales	28221|Deltaproteobacteria	H	Methionine biosynthesis protein MetW	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
HKD2_k127_48426_3	1254432.SCE1572_15565	9.092e-48	181.0	COG1409@1|root,COG1409@2|Bacteria	2|Bacteria	S	acid phosphatase activity	-	-	3.1.4.53	ko:K03651	ko00230,ko02025,map00230,map02025	-	R00191	RC00296	ko00000,ko00001,ko01000	-	-	-	F5_F8_type_C,Laminin_G_3,Metallophos,Metallophos_2,NAGLU,NAGLU_C,NAGLU_N
HKD2_k127_48426_0	1123258.AQXZ01000018_gene668	5.795e-103	343.0	COG1233@1|root,COG1233@2|Bacteria	2|Bacteria	Q	all-trans-retinol 13,14-reductase activity	-	-	1.3.99.23,5.2.1.13	ko:K09516,ko:K09835	ko00830,ko00906,ko01100,ko01110,map00830,map00906,map01100,map01110	M00097	R07163,R07512	RC01835,RC01960	ko00000,ko00001,ko00002,ko01000	-	-	-	Amino_oxidase,NAD_binding_8
HKD2_k127_485019_0	448385.sce7295	2.26e-63	240.0	COG0515@1|root,COG0515@2|Bacteria,1Q2R6@1224|Proteobacteria,433VB@68525|delta/epsilon subdivisions,2X3MY@28221|Deltaproteobacteria,2YWK6@29|Myxococcales	28221|Deltaproteobacteria	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HKD2_k127_4877749_8	1192034.CAP_6941	6.666e-56	204.0	COG1579@1|root,COG1579@2|Bacteria,1R7GT@1224|Proteobacteria,42P3S@68525|delta/epsilon subdivisions,2WKVG@28221|Deltaproteobacteria,2YVT7@29|Myxococcales	28221|Deltaproteobacteria	S	C4-type zinc ribbon domain	-	-	-	ko:K07164	-	-	-	-	ko00000	-	-	-	zf-RING_7
HKD2_k127_4877749_2	448385.sce3781	4.174e-122	405.0	COG0515@1|root,COG0515@2|Bacteria	448385.sce3781|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4877749_6	448385.sce1768	8.914e-93	322.0	2A4SI@1|root,30TDY@2|Bacteria,1PD6V@1224|Proteobacteria,435EQ@68525|delta/epsilon subdivisions,2X98Q@28221|Deltaproteobacteria,2Z2N2@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4877749_0	1254432.SCE1572_03375	0.0	1086.0	COG2304@1|root,COG3266@1|root,COG5426@1|root,COG2304@2|Bacteria,COG3266@2|Bacteria,COG5426@2|Bacteria,1N4IM@1224|Proteobacteria,437ZC@68525|delta/epsilon subdivisions,2WZWU@28221|Deltaproteobacteria,2YUXT@29|Myxococcales	28221|Deltaproteobacteria	S	von Willebrand factor type A domain	-	-	-	-	-	-	-	-	-	-	-	-	VWA,VWA_2,VWA_3
HKD2_k127_4877749_1	1192034.CAP_0821	1.127e-190	616.0	COG2304@1|root,COG2304@2|Bacteria,1QB89@1224|Proteobacteria,435EV@68525|delta/epsilon subdivisions,2WZSF@28221|Deltaproteobacteria,2Z2NJ@29|Myxococcales	28221|Deltaproteobacteria	S	Aerotolerance regulator N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	BatA,VWA_2
HKD2_k127_4877749_9	84531.JMTZ01000013_gene2848	5.881e-13	81.0	2EHW5@1|root,33BMQ@2|Bacteria,1P29Q@1224|Proteobacteria,1T710@1236|Gammaproteobacteria,1X8K7@135614|Xanthomonadales	135614|Xanthomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4877749_7	886293.Sinac_7451	2.365e-84	313.0	2EU85@1|root,33MQK@2|Bacteria,2J4RA@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4877749_3	448385.sce5974	3.411e-121	393.0	COG0412@1|root,COG0412@2|Bacteria,1PSEB@1224|Proteobacteria,4340G@68525|delta/epsilon subdivisions,2X4F0@28221|Deltaproteobacteria,2YYWA@29|Myxococcales	28221|Deltaproteobacteria	Q	Dienelactone hydrolase and related enzymes	-	-	-	-	-	-	-	-	-	-	-	-	DLH
HKD2_k127_4877749_5	1192034.CAP_0820	1.641e-97	346.0	COG1721@1|root,COG1721@2|Bacteria,1MWPG@1224|Proteobacteria,42ZX4@68525|delta/epsilon subdivisions,2WVHE@28221|Deltaproteobacteria,2YUT3@29|Myxococcales	28221|Deltaproteobacteria	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
HKD2_k127_4877749_4	1254432.SCE1572_42850	3.723e-108	365.0	COG1277@1|root,COG1277@2|Bacteria,1Q3SM@1224|Proteobacteria,4342Q@68525|delta/epsilon subdivisions,2X4XP@28221|Deltaproteobacteria,2YZT2@29|Myxococcales	28221|Deltaproteobacteria	S	ABC-type transport system involved in multi-copper enzyme maturation permease component	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane_3
HKD2_k127_488631_0	1254432.SCE1572_41245	5.085e-235	740.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,439ZU@68525|delta/epsilon subdivisions,2X20B@28221|Deltaproteobacteria,2YZC0@29|Myxococcales	28221|Deltaproteobacteria	IQ	AMP-binding enzyme	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding
HKD2_k127_488631_3	391623.TERMP_02125	7.941e-06	57.0	arCOG08355@1|root,arCOG09679@1|root,arCOG08355@2157|Archaea,arCOG09679@2157|Archaea,2Y35P@28890|Euryarchaeota	2157|Archaea	S	PFAM PEGA domain	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	TPR_3
HKD2_k127_488631_2	1254432.SCE1572_11200	3.991e-147	499.0	COG0745@1|root,COG4191@1|root,COG0745@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42M6C@68525|delta/epsilon subdivisions,2WM3G@28221|Deltaproteobacteria,2YV02@29|Myxococcales	28221|Deltaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_4,Response_reg
HKD2_k127_488631_1	1254432.SCE1572_03680	1.301e-156	503.0	COG0064@1|root,COG0064@2|Bacteria,1MUKG@1224|Proteobacteria,42M31@68525|delta/epsilon subdivisions,2WJK4@28221|Deltaproteobacteria,2YUCW@29|Myxococcales	28221|Deltaproteobacteria	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatB	GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	GatB_N,GatB_Yqey
HKD2_k127_4915470_1	1297742.A176_06154	1.412e-49	188.0	COG1738@1|root,COG1738@2|Bacteria,1NIPE@1224|Proteobacteria,42RW2@68525|delta/epsilon subdivisions,2WNR6@28221|Deltaproteobacteria,2YW47@29|Myxococcales	28221|Deltaproteobacteria	U	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage	-	-	-	ko:K09125	-	-	-	-	ko00000	-	-	-	Vut_1
HKD2_k127_4915470_4	1235835.C814_02810	8.929e-21	101.0	COG1357@1|root,COG1357@2|Bacteria,1VAPB@1239|Firmicutes,24J9N@186801|Clostridia	186801|Clostridia	S	Pentapeptide repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	Pentapeptide,Pentapeptide_4
HKD2_k127_4915470_0	215803.DB30_6615	1.024e-234	739.0	COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,42PGV@68525|delta/epsilon subdivisions,2WIS0@28221|Deltaproteobacteria,2YY1D@29|Myxococcales	28221|Deltaproteobacteria	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
HKD2_k127_4915470_2	1313421.JHBV01000043_gene3191	3.076e-34	139.0	COG3000@1|root,COG3000@2|Bacteria	2|Bacteria	I	iron ion binding	-	-	-	-	-	-	-	-	-	-	-	-	FA_hydroxylase
HKD2_k127_4915470_3	999541.bgla_2g09970	2.24e-24	115.0	COG1309@1|root,COG1309@2|Bacteria,1N4J6@1224|Proteobacteria,2WFDX@28216|Betaproteobacteria	28216|Betaproteobacteria	K	Tetracyclin repressor, C-terminal all-alpha domain	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C,TetR_N
HKD2_k127_4922377_0	448385.sce3845	1.575e-137	442.0	COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,42M6W@68525|delta/epsilon subdivisions,2WIZF@28221|Deltaproteobacteria,2YUFJ@29|Myxococcales	28221|Deltaproteobacteria	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	relA	-	2.7.6.5	ko:K00951	ko00230,map00230	-	R00429	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
HKD2_k127_4922377_3	1303518.CCALI_00694	0.0004634	50.0	COG0457@1|root,COG0457@2|Bacteria	1303518.CCALI_00694|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4922377_1	1192034.CAP_6500	2.363e-125	415.0	COG0635@1|root,COG0635@2|Bacteria,1MU76@1224|Proteobacteria,42NGU@68525|delta/epsilon subdivisions,2WIM5@28221|Deltaproteobacteria,2YUZF@29|Myxococcales	28221|Deltaproteobacteria	H	Involved in the biosynthesis of porphyrin-containing compound	hemN	-	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
HKD2_k127_4922377_2	590998.Celf_0262	9.145e-85	302.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,2GMMM@201174|Actinobacteria,4F1VG@85016|Cellulomonadaceae	201174|Actinobacteria	EU	Prolyl oligopeptidase family	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
HKD2_k127_495106_0	448385.sce2164	8.664e-100	345.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria	1224|Proteobacteria	C	Belongs to the aldehyde dehydrogenase family	-	-	1.2.99.10	ko:K22445	-	-	-	-	ko00000,ko01000	-	-	-	Aldedh
HKD2_k127_495106_1	937777.Deipe_2732	1.183e-50	201.0	COG3483@1|root,COG3483@2|Bacteria	2|Bacteria	E	tryptophan 2,3-dioxygenase activity	kynA	GO:0003674,GO:0003824,GO:0004833,GO:0005488,GO:0006082,GO:0006520,GO:0006568,GO:0006569,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009072,GO:0009074,GO:0009308,GO:0009310,GO:0009987,GO:0016043,GO:0016054,GO:0016491,GO:0016701,GO:0016702,GO:0019439,GO:0019441,GO:0019752,GO:0020037,GO:0022607,GO:0034641,GO:0042180,GO:0042402,GO:0042430,GO:0042436,GO:0042537,GO:0043436,GO:0043933,GO:0044085,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0046218,GO:0046395,GO:0046483,GO:0046700,GO:0046906,GO:0048037,GO:0051213,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0070189,GO:0071704,GO:0071840,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	1.13.11.11,4.1.1.45	ko:K00453,ko:K03392	ko00380,ko01100,map00380,map01100	M00038	R00678,R04323	RC00356,RC00779	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_dioxygenase
HKD2_k127_5018675_5	448385.sce9358	0.0001872	49.0	COG2189@1|root,COG2189@2|Bacteria,1MX9M@1224|Proteobacteria,42RUT@68525|delta/epsilon subdivisions,2X9ZW@28221|Deltaproteobacteria,2Z1HJ@29|Myxococcales	28221|Deltaproteobacteria	L	Belongs to the N(4) N(6)-methyltransferase family	-	-	2.1.1.72	ko:K00571	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
HKD2_k127_5018675_2	1192034.CAP_2416	1.802e-69	246.0	COG3770@1|root,COG3770@2|Bacteria,1QA7G@1224|Proteobacteria,43DYC@68525|delta/epsilon subdivisions,2WZ6W@28221|Deltaproteobacteria,2Z1GB@29|Myxococcales	28221|Deltaproteobacteria	M	Penicillin-insensitive murein endopeptidase	-	-	-	ko:K07261	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_M74
HKD2_k127_5018675_4	452637.Oter_2380	7.811e-08	63.0	2ETF9@1|root,33KZ8@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF4412)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4412
HKD2_k127_5018675_0	1278073.MYSTI_00099	2.348e-103	338.0	COG0035@1|root,COG0035@2|Bacteria,1MV4N@1224|Proteobacteria,42NNR@68525|delta/epsilon subdivisions,2WK6M@28221|Deltaproteobacteria,2YYH6@29|Myxococcales	28221|Deltaproteobacteria	F	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate	upp	GO:0003674,GO:0003824,GO:0004849,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006213,GO:0006220,GO:0006221,GO:0006222,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008655,GO:0009058,GO:0009112,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009173,GO:0009174,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0018130,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0043094,GO:0043097,GO:0043174,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046049,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.4.2.9	ko:K00761	ko00240,ko01100,map00240,map01100	-	R00966	RC00063	ko00000,ko00001,ko01000	-	-	-	UPRTase
HKD2_k127_5018675_1	1192034.CAP_2417	4.101e-74	259.0	COG2937@1|root,COG2937@2|Bacteria,1MWZ6@1224|Proteobacteria,42MN4@68525|delta/epsilon subdivisions,2WJJ5@28221|Deltaproteobacteria,2YW2Y@29|Myxococcales	28221|Deltaproteobacteria	I	Belongs to the GPAT DAPAT family	plsB	-	2.3.1.15	ko:K00631	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
HKD2_k127_502897_7	1254432.SCE1572_11010	3.071e-46	178.0	2A4SI@1|root,30TDY@2|Bacteria,1PD6V@1224|Proteobacteria,435EQ@68525|delta/epsilon subdivisions,2X98Q@28221|Deltaproteobacteria,2Z2N2@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_502897_2	1463858.JOHR01000001_gene6186	4.716e-94	342.0	COG2303@1|root,COG2303@2|Bacteria,2I5YA@201174|Actinobacteria	2|Bacteria	E	oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GMC_oxred_C
HKD2_k127_502897_9	932213.SPM24T3_03672	1.609e-11	75.0	2DB8V@1|root,2Z7SX@2|Bacteria,1MX06@1224|Proteobacteria,1RQMZ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Gluconate 2-dehydrogenase subunit 3	-	-	1.1.99.3	ko:K06152	ko00030,ko01100,ko01120,map00030,map01100,map01120	-	R01741	RC00084	ko00000,ko00001,ko01000	-	-	-	Gluconate_2-dh3
HKD2_k127_502897_0	1254432.SCE1572_43935	5.051e-192	636.0	COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,42MKU@68525|delta/epsilon subdivisions,2WJR3@28221|Deltaproteobacteria,2YUNQ@29|Myxococcales	28221|Deltaproteobacteria	L	DNA helicase	rep	-	3.6.4.12	ko:K03656,ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
HKD2_k127_502897_1	448385.sce7598	2.003e-135	441.0	COG0626@1|root,COG0626@2|Bacteria,1MU57@1224|Proteobacteria,42M67@68525|delta/epsilon subdivisions,2WJQX@28221|Deltaproteobacteria,2YY2Q@29|Myxococcales	28221|Deltaproteobacteria	H	Cys/Met metabolism PLP-dependent enzyme	-	-	2.5.1.48	ko:K01739	ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017	R00999,R01288,R02508,R03217,R03260,R04944,R04945,R04946	RC00020,RC00056,RC00069,RC00420,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000	-	-	-	Cys_Met_Meta_PP
HKD2_k127_502897_4	1254432.SCE1572_17850	4.008e-48	195.0	COG2960@1|root,COG2960@2|Bacteria,1R494@1224|Proteobacteria,43CJP@68525|delta/epsilon subdivisions,2X7U1@28221|Deltaproteobacteria,2YXZK@29|Myxococcales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF1552)	-	-	-	-	-	-	-	-	-	-	-	-	HXXSHH
HKD2_k127_502897_3	1254432.SCE1572_17845	1.306e-55	205.0	COG5297@1|root,COG5297@2|Bacteria,1MV16@1224|Proteobacteria,430JB@68525|delta/epsilon subdivisions,2WVTU@28221|Deltaproteobacteria,2YWQ0@29|Myxococcales	28221|Deltaproteobacteria	G	Protein of unknown function (DUF1592)	-	-	-	-	-	-	-	-	-	-	-	-	PSCyt3,PSD2,PSD3,PSD4,PSD5
HKD2_k127_503304_6	570268.ANBB01000050_gene4047	0.0004714	52.0	COG0457@1|root,COG0457@2|Bacteria,2IC3X@201174|Actinobacteria	201174|Actinobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_503304_4	1163617.SCD_n00775	4.17e-11	77.0	2EBX9@1|root,335WM@2|Bacteria,1NCDM@1224|Proteobacteria,2VYXB@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_503304_0	1144275.COCOR_07429	4.51e-231	734.0	COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,1MU9U@1224|Proteobacteria,42N86@68525|delta/epsilon subdivisions,2WIV4@28221|Deltaproteobacteria,2YTUK@29|Myxococcales	28221|Deltaproteobacteria	H	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source	nadE	-	6.3.5.1	ko:K01950	ko00760,ko01100,map00760,map01100	M00115	R00257	RC00010,RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase,NAD_synthase
HKD2_k127_503304_1	1205680.CAKO01000006_gene3158	1.917e-131	433.0	COG3200@1|root,COG3200@2|Bacteria,1MUWF@1224|Proteobacteria,2TR0E@28211|Alphaproteobacteria,2JV6R@204441|Rhodospirillales	204441|Rhodospirillales	E	Class-II DAHP synthetase family	-	-	-	-	-	-	-	-	-	-	-	-	DAHP_synth_2
HKD2_k127_503304_3	448385.sce7743	6.592e-37	147.0	COG1595@1|root,COG1595@2|Bacteria,1QA32@1224|Proteobacteria,434TA@68525|delta/epsilon subdivisions,2WZ4A@28221|Deltaproteobacteria,2Z1AN@29|Myxococcales	28221|Deltaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD2_k127_503304_2	448385.sce2449	8.623e-62	216.0	COG0741@1|root,COG0741@2|Bacteria,1MZ4X@1224|Proteobacteria,42TVX@68525|delta/epsilon subdivisions,2WP4F@28221|Deltaproteobacteria,2YV7H@29|Myxococcales	28221|Deltaproteobacteria	M	Transglycosylase	-	-	-	ko:K08309	-	-	-	-	ko00000,ko01000,ko01011	-	GH23	-	DUF4124,SLT
HKD2_k127_50404_6	1254432.SCE1572_43765	0.000392	44.0	COG5394@1|root,COG5394@2|Bacteria,1RHRC@1224|Proteobacteria,42WB9@68525|delta/epsilon subdivisions,2WSSJ@28221|Deltaproteobacteria,2YVJB@29|Myxococcales	28221|Deltaproteobacteria	S	PHB/PHA accumulation regulator DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	PHB_acc_N
HKD2_k127_50404_2	1254432.SCE1572_43770	3.236e-89	299.0	COG1595@1|root,COG1595@2|Bacteria,1PEJM@1224|Proteobacteria,4380A@68525|delta/epsilon subdivisions,2X3AB@28221|Deltaproteobacteria,2YV3Y@29|Myxococcales	28221|Deltaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	rpoE	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD2_k127_50404_4	1192034.CAP_1995	5.269e-34	147.0	COG5662@1|root,COG5662@2|Bacteria,1PC36@1224|Proteobacteria,4387X@68525|delta/epsilon subdivisions,2X3HP@28221|Deltaproteobacteria,2YW5D@29|Myxococcales	28221|Deltaproteobacteria	K	Putative zinc-finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
HKD2_k127_50404_1	1192034.CAP_1996	1.94e-107	370.0	COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,42NY8@68525|delta/epsilon subdivisions,2WJNT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	gamma-glutamyltransferase	ggt	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
HKD2_k127_50404_0	448385.sce7568	2.747e-120	394.0	COG0189@1|root,COG0189@2|Bacteria,1MVUA@1224|Proteobacteria,42SG1@68525|delta/epsilon subdivisions,2WP1E@28221|Deltaproteobacteria,2YUU8@29|Myxococcales	28221|Deltaproteobacteria	H	Belongs to the prokaryotic GSH synthase family	gshB	-	6.3.2.3	ko:K01920	ko00270,ko00480,ko01100,map00270,map00480,map01100	M00118	R00497,R10994	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	GSH-S_ATP,GSH-S_N
HKD2_k127_50404_5	197221.22295053	5.361e-13	82.0	COG0842@1|root,COG1131@1|root,COG1716@1|root,COG0842@2|Bacteria,COG1131@2|Bacteria,COG1716@2|Bacteria,1G102@1117|Cyanobacteria	1117|Cyanobacteria	V	ABC-type multidrug transport system ATPase component	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane,ABC_tran,FHA
HKD2_k127_50404_3	290397.Adeh_3649	1.709e-55	216.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,42Q67@68525|delta/epsilon subdivisions,2WKZ1@28221|Deltaproteobacteria,2YZ6I@29|Myxococcales	28221|Deltaproteobacteria	KLT	Serine Threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HKD2_k127_5071402_0	1254432.SCE1572_35885	2.969e-74	267.0	COG0642@1|root,COG2203@1|root,COG5000@1|root,COG2203@2|Bacteria,COG2205@2|Bacteria,COG5000@2|Bacteria,1QV0D@1224|Proteobacteria,438B0@68525|delta/epsilon subdivisions,2X3KB@28221|Deltaproteobacteria,2YWEE@29|Myxococcales	28221|Deltaproteobacteria	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS_4,RsbRD_N
HKD2_k127_5071402_2	1352941.M877_35255	1.019e-14	84.0	COG2146@1|root,COG2146@2|Bacteria,2IKSY@201174|Actinobacteria	201174|Actinobacteria	P	Rieske 2Fe-2S	-	-	-	-	-	-	-	-	-	-	-	-	Rieske
HKD2_k127_5071402_1	1254432.SCE1572_39470	3.987e-42	159.0	COG1656@1|root,COG1656@2|Bacteria,1R442@1224|Proteobacteria,42RIS@68525|delta/epsilon subdivisions,2WMWC@28221|Deltaproteobacteria,2Z1X2@29|Myxococcales	28221|Deltaproteobacteria	S	Mut7-C RNAse domain	-	-	-	ko:K09122	-	-	-	-	ko00000	-	-	-	Mut7-C,Ub-Mut7C
HKD2_k127_5083354_3	1210884.HG799462_gene7876	3.174e-23	106.0	COG1506@1|root,COG1506@2|Bacteria,2IYRT@203682|Planctomycetes	203682|Planctomycetes	E	Dipeptidyl peptidase IV (DPP IV)	-	-	3.4.14.5	ko:K01278	ko04974,map04974	-	-	-	ko00000,ko00001,ko01000,ko01002,ko04090,ko04147	-	-	-	DPPIV_N,Peptidase_S9
HKD2_k127_5083354_2	1828.JOKB01000061_gene1816	5.999e-29	135.0	2EWTS@1|root,33Q5B@2|Bacteria,2HZQX@201174|Actinobacteria,4FXWW@85025|Nocardiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5083354_5	284031.JNXD01000021_gene7635	6.805e-18	98.0	COG0491@1|root,COG0491@2|Bacteria,2H8JM@201174|Actinobacteria	201174|Actinobacteria	S	COG0491 Zn-dependent hydrolases, including glyoxylases	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HKD2_k127_5083354_0	1292034.OR37_03761	1.133e-89	323.0	COG1230@1|root,COG1230@2|Bacteria,1MVQB@1224|Proteobacteria,2TR65@28211|Alphaproteobacteria,2KF1I@204458|Caulobacterales	204458|Caulobacterales	P	cation diffusion facilitator family transporter	-	-	-	ko:K16264	-	-	-	-	ko00000,ko02000	2.A.4.1	-	-	Cation_efflux
HKD2_k127_5083354_4	502025.Hoch_3964	1.854e-18	99.0	COG0810@1|root,COG0810@2|Bacteria	2|Bacteria	M	energy transducer activity	tonB2	-	-	ko:K03832,ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33,2.C.1.1	-	-	TonB_2,TonB_C
HKD2_k127_5083354_6	378806.STAUR_2686	6.121e-17	95.0	COG0457@1|root,COG0457@2|Bacteria,1PDTX@1224|Proteobacteria,42RK5@68525|delta/epsilon subdivisions,2WNZC@28221|Deltaproteobacteria,2YW1B@29|Myxococcales	28221|Deltaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	SPOR,TPR_1,TPR_11,TPR_16,TPR_19,TPR_2,TPR_8
HKD2_k127_5083354_1	502025.Hoch_3961	6.912e-47	179.0	COG1729@1|root,COG1729@2|Bacteria,1MX82@1224|Proteobacteria,42TQ9@68525|delta/epsilon subdivisions,2WR3B@28221|Deltaproteobacteria	1224|Proteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_6,TPR_8,YfiO
HKD2_k127_5089160_0	1192034.CAP_5311	8.959e-320	1008.0	COG0457@1|root,COG4760@1|root,COG0457@2|Bacteria,COG4760@2|Bacteria,1QZT2@1224|Proteobacteria,4331A@68525|delta/epsilon subdivisions	1224|Proteobacteria	H	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_509374_0	502025.Hoch_4153	1.356e-142	467.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2YUJ9@29|Myxococcales	28221|Deltaproteobacteria	T	Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains	pilR	-	-	ko:K02667	ko02020,map02020	M00501	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD2_k127_5103734_1	1449126.JQKL01000003_gene1791	1.131e-107	361.0	COG4962@1|root,COG4962@2|Bacteria,1TQ0Z@1239|Firmicutes,249VS@186801|Clostridia,267PU@186813|unclassified Clostridiales	186801|Clostridia	U	Psort location Cytoplasmic, score	-	-	-	ko:K02283	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
HKD2_k127_5103734_5	886293.Sinac_2481	1.039e-22	107.0	COG0110@1|root,COG0110@2|Bacteria,2J17A@203682|Planctomycetes	203682|Planctomycetes	S	PFAM Bacterial transferase hexapeptide (three repeats)	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep,Hexapep_2
HKD2_k127_5103734_3	448385.sce5737	1.437e-41	159.0	COG2050@1|root,COG2050@2|Bacteria	2|Bacteria	Q	thiolester hydrolase activity	ydiI	-	-	-	-	-	-	-	-	-	-	-	4HBT,Hydrolase_3
HKD2_k127_5103734_4	870187.Thini_3864	2.438e-34	136.0	COG3791@1|root,COG3791@2|Bacteria,1N031@1224|Proteobacteria,1S8W1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	PFAM glutathione-dependent formaldehyde-activating	-	-	-	-	-	-	-	-	-	-	-	-	GFA
HKD2_k127_5103734_2	1449069.JMLO01000009_gene4160	1.372e-42	173.0	COG2730@1|root,COG2730@2|Bacteria,2HQAQ@201174|Actinobacteria,4G5N3@85025|Nocardiaceae	201174|Actinobacteria	G	Beta-galactosidase	-	-	-	-	-	-	-	-	-	-	-	-	Cellulase
HKD2_k127_5103734_7	1284679.HMPREF1626_08970	3.162e-08	65.0	COG0509@1|root,COG0509@2|Bacteria,2IKN2@201174|Actinobacteria,4D5YY@85005|Actinomycetales	201174|Actinobacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	gcvH	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
HKD2_k127_5103734_0	404589.Anae109_3668	2.076e-147	489.0	COG2197@1|root,COG2197@2|Bacteria,1R03J@1224|Proteobacteria	1224|Proteobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE
HKD2_k127_5103734_6	1380391.JIAS01000019_gene1261	1.118e-12	78.0	COG2128@1|root,COG2128@2|Bacteria,1N1YR@1224|Proteobacteria,2UENK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5113124_0	448385.sce8336	2.92e-131	439.0	COG0616@1|root,COG0616@2|Bacteria,1MUXE@1224|Proteobacteria,42QUN@68525|delta/epsilon subdivisions,2WN6Q@28221|Deltaproteobacteria,2YU60@29|Myxococcales	28221|Deltaproteobacteria	OU	signal peptide peptidase SppA, 36K type	sppA2	-	-	ko:K04773	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S49
HKD2_k127_5116243_0	448385.sce3841	8.438e-171	541.0	COG0714@1|root,COG0714@2|Bacteria,1QA7C@1224|Proteobacteria,4342N@68525|delta/epsilon subdivisions,2X4WR@28221|Deltaproteobacteria,2YZRP@29|Myxococcales	28221|Deltaproteobacteria	S	AAA domain (dynein-related subfamily)	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_5
HKD2_k127_5116243_2	1192034.CAP_7147	5.401e-15	88.0	COG1214@1|root,COG1214@2|Bacteria,1MXPH@1224|Proteobacteria,42RIT@68525|delta/epsilon subdivisions,2WP64@28221|Deltaproteobacteria,2Z1V2@29|Myxococcales	28221|Deltaproteobacteria	O	Glycoprotease family	yeaZ	-	2.3.1.234	ko:K01409,ko:K14742	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
HKD2_k127_5116243_3	402777.KB235903_gene2003	4.185e-07	61.0	2EK9W@1|root,33E06@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5116243_1	290397.Adeh_0078	2.867e-22	99.0	2A9VF@1|root,30Z3B@2|Bacteria,1PKZS@1224|Proteobacteria,435JG@68525|delta/epsilon subdivisions,2WZXJ@28221|Deltaproteobacteria,2Z0YG@29|Myxococcales	290397.Adeh_0078|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5124560_0	1254432.SCE1572_11095	1.272e-102	344.0	COG3246@1|root,COG3246@2|Bacteria,1MZTP@1224|Proteobacteria,42QYC@68525|delta/epsilon subdivisions,2WN66@28221|Deltaproteobacteria,2Z2W4@29|Myxococcales	28221|Deltaproteobacteria	S	Pfam:Kce	-	-	-	-	-	-	-	-	-	-	-	-	BKACE
HKD2_k127_5124560_2	448385.sce1783	5.729e-48	185.0	COG1846@1|root,COG1846@2|Bacteria,1N244@1224|Proteobacteria,42TYY@68525|delta/epsilon subdivisions,2WQP5@28221|Deltaproteobacteria,2YW5J@29|Myxococcales	28221|Deltaproteobacteria	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	MarR
HKD2_k127_5124560_1	448385.sce8814	2.545e-99	351.0	COG1858@1|root,COG3391@1|root,COG1858@2|Bacteria,COG3391@2|Bacteria,1R7E0@1224|Proteobacteria,42XD8@68525|delta/epsilon subdivisions,2WT8U@28221|Deltaproteobacteria,2YV4I@29|Myxococcales	28221|Deltaproteobacteria	C	TIGRFAM 40-residue YVTN family beta-propeller repeat	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,Cytochrome_C7
HKD2_k127_5127344_0	1192034.CAP_5772	3.954e-254	797.0	COG0443@1|root,COG0443@2|Bacteria,1MVEN@1224|Proteobacteria,42M64@68525|delta/epsilon subdivisions,2WIWS@28221|Deltaproteobacteria,2YUFN@29|Myxococcales	28221|Deltaproteobacteria	O	Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB	hscA	-	-	ko:K04044	-	-	-	-	ko00000,ko03110	1.A.33	-	-	HSP70
HKD2_k127_5127344_9	1254432.SCE1572_42670	4.276e-41	166.0	COG0633@1|root,COG0633@2|Bacteria,1Q2HK@1224|Proteobacteria,4384E@68525|delta/epsilon subdivisions,2X3EB@28221|Deltaproteobacteria,2YVPH@29|Myxococcales	28221|Deltaproteobacteria	C	2Fe-2S iron-sulfur cluster binding domain	-	-	-	ko:K04755	-	-	-	-	ko00000	-	-	-	Fer2
HKD2_k127_5127344_16	640081.Dsui_1243	0.0006684	51.0	COG4254@1|root,COG4254@2|Bacteria,1PGBS@1224|Proteobacteria,2VQEE@28216|Betaproteobacteria,2M02Z@206389|Rhodocyclales	206389|Rhodocyclales	S	FecR protein	-	-	-	-	-	-	-	-	-	-	-	-	FecR
HKD2_k127_5127344_15	1120965.AUBV01000006_gene2367	4.301e-06	56.0	COG2846@1|root,COG2846@2|Bacteria,4NE9M@976|Bacteroidetes,47V0J@768503|Cytophagia	976|Bacteroidetes	D	Domain of Unknown function (DUF542)	ric	-	-	ko:K07322	-	-	-	-	ko00000	-	-	-	Hemerythrin,ScdA_N
HKD2_k127_5127344_3	502025.Hoch_2165	7.5e-107	375.0	COG0645@1|root,COG2187@1|root,COG0645@2|Bacteria,COG2187@2|Bacteria,1MU9M@1224|Proteobacteria,42NEZ@68525|delta/epsilon subdivisions,2WJ5R@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	AAA domain	-	-	-	ko:K07028	-	-	-	-	ko00000	-	-	-	AAA_33,APH
HKD2_k127_5127344_5	1278073.MYSTI_00174	1.284e-84	298.0	COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,4345V@68525|delta/epsilon subdivisions,2WYPY@28221|Deltaproteobacteria,2YUFV@29|Myxococcales	28221|Deltaproteobacteria	K	Bacterial regulatory protein, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Sigma54_activat
HKD2_k127_5127344_13	1390370.O203_07180	1.356e-18	100.0	COG3202@1|root,COG3202@2|Bacteria,1MVP5@1224|Proteobacteria,1RNY6@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	ATP ADP translocase	-	-	-	ko:K03301	-	-	-	-	ko00000	2.A.12	-	-	MFS_1,TLC
HKD2_k127_5127344_10	1150398.JIBJ01000013_gene2549	3.75e-39	157.0	COG3511@1|root,COG3511@2|Bacteria	2|Bacteria	M	phospholipase C	-	-	3.1.3.64	ko:K21302	ko00562,ko01100,ko05152,map00562,map01100,map05152	-	-	-	ko00000,ko00001,ko01000	-	-	-	Phosphoesterase
HKD2_k127_5127344_7	42256.RradSPS_2425	3.454e-68	264.0	COG2199@1|root,COG3706@2|Bacteria,2HENY@201174|Actinobacteria,4CQWS@84995|Rubrobacteria	84995|Rubrobacteria	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,Hpt,Response_reg
HKD2_k127_5127344_12	864073.HFRIS_005128	5.264e-20	105.0	COG0716@1|root,COG0716@2|Bacteria,1NANK@1224|Proteobacteria,2VW78@28216|Betaproteobacteria,477Q2@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	Flavodoxin	-	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_4
HKD2_k127_5127344_6	448385.sce6264	2.049e-79	288.0	COG4775@1|root,COG4775@2|Bacteria	2|Bacteria	M	membrane organization	-	-	-	-	-	-	-	-	-	-	-	-	Bac_surface_Ag,CarboxypepD_reg,Laminin_G_3,POTRA
HKD2_k127_5127344_14	43759.JNWK01000074_gene6384	3.811e-08	61.0	COG0517@1|root,COG0517@2|Bacteria,2GKSH@201174|Actinobacteria	201174|Actinobacteria	C	Cbs domain	-	-	-	-	-	-	-	-	-	-	-	-	BON,CBS
HKD2_k127_5127344_4	1254432.SCE1572_52190	2.142e-101	343.0	COG2059@1|root,COG2059@2|Bacteria,1MUBW@1224|Proteobacteria,42QCN@68525|delta/epsilon subdivisions,2WIYT@28221|Deltaproteobacteria,2YV4K@29|Myxococcales	28221|Deltaproteobacteria	P	Chromate transporter	chrA	-	-	ko:K07240	-	-	-	-	ko00000,ko02000	2.A.51.1	-	-	Chromate_transp
HKD2_k127_5127344_1	644966.Tmar_0901	1.177e-203	657.0	COG0045@1|root,COG1042@1|root,COG1670@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,COG1670@2|Bacteria,1TPTQ@1239|Firmicutes,249CX@186801|Clostridia,3WD0A@538999|Clostridiales incertae sedis	186801|Clostridia	C	TIGRFAM acetyl coenzyme A synthetase (ADP forming), alpha domain	-	-	6.2.1.13	ko:K01905,ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5,Acetyltransf_1,CoA_binding_2,Succ_CoA_lig
HKD2_k127_5127707_2	448385.sce8173	1.387e-138	445.0	COG1138@1|root,COG1138@2|Bacteria,1MUQS@1224|Proteobacteria,42P4Q@68525|delta/epsilon subdivisions,2WK5G@28221|Deltaproteobacteria,2YU4N@29|Myxococcales	28221|Deltaproteobacteria	O	Cytochrome c-type biogenesis protein	ccmF	-	-	ko:K02198	-	-	-	-	ko00000,ko02000	9.B.14.1	-	-	CcmF_C,Cytochrom_C_asm
HKD2_k127_5127707_7	404589.Anae109_0731	2.003e-05	53.0	COG3031@1|root,COG3031@2|Bacteria,1PUWN@1224|Proteobacteria,42T73@68525|delta/epsilon subdivisions,2WR4E@28221|Deltaproteobacteria	28221|Deltaproteobacteria	U	Domain present in PSD-95, Dlg, and ZO-1/2.	-	-	-	ko:K02452	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSC
HKD2_k127_5127707_4	1254432.SCE1572_05565	9.666e-46	179.0	COG0697@1|root,COG0697@2|Bacteria,1NS7A@1224|Proteobacteria,42MCJ@68525|delta/epsilon subdivisions,2WKQ4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HKD2_k127_5127707_6	1242864.D187_004371	5.795e-07	61.0	COG1868@1|root,COG1886@1|root,COG1868@2|Bacteria,COG1886@2|Bacteria,1N8MX@1224|Proteobacteria	1224|Proteobacteria	NU	COG1886 Flagellar motor switch type III secretory pathway protein	-	-	-	ko:K02416,ko:K03225	ko02030,ko02040,ko03070,map02030,map02040,map03070	M00332,M00542,M00660	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.6.1	-	-	FliM,FliMN_C
HKD2_k127_5127707_3	344747.PM8797T_11099	5.823e-54	198.0	COG0500@1|root,COG2226@2|Bacteria,2IZD4@203682|Planctomycetes	203682|Planctomycetes	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
HKD2_k127_5127707_5	1254432.SCE1572_45445	8.002e-30	134.0	COG0457@1|root,COG0457@2|Bacteria	1254432.SCE1572_45445|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5127707_0	1254432.SCE1572_41965	1.773e-315	1031.0	COG0457@1|root,COG0457@2|Bacteria,1Q2H1@1224|Proteobacteria,4383J@68525|delta/epsilon subdivisions,2X3DM@28221|Deltaproteobacteria,2YVKC@29|Myxococcales	28221|Deltaproteobacteria	NU	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	DUF3857,DUF3858,TPR_16,TPR_19
HKD2_k127_5127707_1	448385.sce7247	8.109e-192	614.0	COG0457@1|root,COG1305@1|root,COG0457@2|Bacteria,COG1305@2|Bacteria,1R5BE@1224|Proteobacteria,4339F@68525|delta/epsilon subdivisions,2WYFR@28221|Deltaproteobacteria,2YTXM@29|Myxococcales	28221|Deltaproteobacteria	E	Domain of Unknown Function with PDB structure (DUF3857)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3857,DUF3858,TPR_16,TPR_19,TPR_8,Transglut_core
HKD2_k127_5128268_8	652103.Rpdx1_1891	2.647e-105	346.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria,3JQMT@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	MA20_27115	-	-	ko:K03296,ko:K07788,ko:K07789	ko02020,map02020	M00648	-	-	ko00000,ko00001,ko00002,ko02000	2.A.6.2	-	-	ACR_tran
HKD2_k127_5128268_0	378806.STAUR_3162	0.0	1178.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42YVG@68525|delta/epsilon subdivisions,2WUQA@28221|Deltaproteobacteria,2Z2XI@29|Myxococcales	28221|Deltaproteobacteria	V	MMPL family	-	-	-	ko:K07789	ko02020,map02020	M00648	-	-	ko00000,ko00001,ko00002,ko02000	2.A.6.2	-	-	ACR_tran
HKD2_k127_5128268_4	1192034.CAP_3998	7.425e-201	643.0	COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,42Z0F@68525|delta/epsilon subdivisions,2WTWA@28221|Deltaproteobacteria,2YUMY@29|Myxococcales	28221|Deltaproteobacteria	I	AMP-binding enzyme	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
HKD2_k127_5128268_22	760117.JN27_23905	3.905e-23	111.0	COG2340@1|root,COG2340@2|Bacteria,1N1C8@1224|Proteobacteria,2VUJN@28216|Betaproteobacteria,47906@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Cysteine-rich secretory protein family	-	-	-	-	-	-	-	-	-	-	-	-	CAP
HKD2_k127_5128268_15	1177154.Y5S_02160	2.941e-60	222.0	COG0491@1|root,COG0491@2|Bacteria,1MXKX@1224|Proteobacteria,1RR31@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	COG0491 Zn-dependent hydrolases, including glyoxylases	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HKD2_k127_5128268_23	347834.RHE_CH02049	5.025e-14	83.0	2B14M@1|root,31TIF@2|Bacteria,1RH0J@1224|Proteobacteria,2UASD@28211|Alphaproteobacteria,4BMU1@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF2938)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2938
HKD2_k127_5128268_16	215803.DB30_6366	1.768e-46	178.0	COG0583@1|root,COG0583@2|Bacteria,1MWVB@1224|Proteobacteria,42U9X@68525|delta/epsilon subdivisions,2WQN5@28221|Deltaproteobacteria,2YXWV@29|Myxococcales	28221|Deltaproteobacteria	K	Bacterial regulatory helix-turn-helix protein, lysR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HKD2_k127_5128268_5	653733.Selin_1410	3.402e-116	415.0	COG1022@1|root,COG1022@2|Bacteria	2|Bacteria	I	Amp-dependent synthetase and ligase	fadD	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
HKD2_k127_5128268_6	1254432.SCE1572_25165	2.976e-115	385.0	COG0477@1|root,COG2814@2|Bacteria	2|Bacteria	EGP	Major facilitator Superfamily	yfkF	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_1_like,Sugar_tr
HKD2_k127_5128268_7	740709.A10D4_08844	4.193e-110	362.0	COG1946@1|root,COG1946@2|Bacteria,1MV9R@1224|Proteobacteria,1RPFI@1236|Gammaproteobacteria,2QFF3@267893|Idiomarinaceae	1236|Gammaproteobacteria	I	Acyl-CoA thioesterase	tesB	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006163,GO:0006629,GO:0006631,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009117,GO:0009150,GO:0009259,GO:0009987,GO:0016042,GO:0016054,GO:0016289,GO:0016787,GO:0016788,GO:0016790,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0035383,GO:0042802,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0046483,GO:0047617,GO:0051186,GO:0055086,GO:0071704,GO:0072329,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901575	-	ko:K10805	ko01040,map01040	-	-	-	ko00000,ko00001,ko01000,ko01004	-	-	iAF1260.b0452,iB21_1397.B21_00408,iBWG_1329.BWG_0334,iEC55989_1330.EC55989_0466,iECBD_1354.ECBD_3203,iECB_1328.ECB_00404,iECDH10B_1368.ECDH10B_0408,iECDH1ME8569_1439.ECDH1ME8569_0437,iECD_1391.ECD_00404,iECH74115_1262.ECH74115_0541,iECIAI1_1343.ECIAI1_0456,iECIAI39_1322.ECIAI39_0221,iECO103_1326.ECO103_0429,iECO111_1330.ECO111_0485,iECO26_1355.ECO26_0487,iECSE_1348.ECSE_0478,iECSP_1301.ECSP_0520,iECUMN_1333.ECUMN_0492,iECW_1372.ECW_m0524,iECs_1301.ECs0506,iEKO11_1354.EKO11_3394,iETEC_1333.ETEC_0505,iEcDH1_1363.EcDH1_3157,iEcE24377_1341.EcE24377A_0488,iEcHS_1320.EcHS_A0529,iEcSMS35_1347.EcSMS35_0496,iEcolC_1368.EcolC_3163,iG2583_1286.G2583_0564,iJO1366.b0452,iSSON_1240.SSON_0440,iUMNK88_1353.UMNK88_505,iWFL_1372.ECW_m0524,iY75_1357.Y75_RS02335,iZ_1308.Z0564,ic_1306.c0571	4HBT_3,Acyl_CoA_thio
HKD2_k127_5128268_13	1254432.SCE1572_38195	6.264e-66	234.0	2CNUX@1|root,32SHU@2|Bacteria,1REYT@1224|Proteobacteria,42R1S@68525|delta/epsilon subdivisions,2WMRC@28221|Deltaproteobacteria,2YVEV@29|Myxococcales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF2760)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2760
HKD2_k127_5128268_2	448385.sce6455	9.652e-281	880.0	COG0443@1|root,COG0443@2|Bacteria,1MXX7@1224|Proteobacteria,42NWU@68525|delta/epsilon subdivisions,2WKQQ@28221|Deltaproteobacteria,2YUNI@29|Myxococcales	28221|Deltaproteobacteria	O	MreB/Mbl protein	dnaK4	-	-	-	-	-	-	-	-	-	-	-	HSP70
HKD2_k127_5128268_1	448385.sce6464	0.0	1083.0	COG0443@1|root,COG0443@2|Bacteria,1MXX7@1224|Proteobacteria,42NF1@68525|delta/epsilon subdivisions,2WK52@28221|Deltaproteobacteria,2YUP8@29|Myxococcales	28221|Deltaproteobacteria	O	Belongs to the heat shock protein 70 family	-	-	-	-	-	-	-	-	-	-	-	-	DUF3731,HSP70
HKD2_k127_5128268_20	1123258.AQXZ01000016_gene2517	6.395e-26	121.0	COG0824@1|root,COG0824@2|Bacteria	2|Bacteria	IQ	Thioesterase	fcbC	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT,4HBT_2
HKD2_k127_5128268_18	861299.J421_4314	5.656e-36	147.0	COG0664@1|root,COG0664@2|Bacteria	2|Bacteria	T	cyclic nucleotide binding	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_20,cNMP_binding
HKD2_k127_5128268_10	1500894.JQNN01000001_gene1777	1.806e-80	283.0	COG1028@1|root,COG1028@2|Bacteria,1MXVZ@1224|Proteobacteria,2VIVZ@28216|Betaproteobacteria	28216|Betaproteobacteria	IQ	short-chain dehydrogenase reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HKD2_k127_5128268_3	1382303.JPOM01000001_gene2401	1.43e-209	658.0	COG2723@1|root,COG2723@2|Bacteria,1MWU7@1224|Proteobacteria,2TT4I@28211|Alphaproteobacteria,2KI8T@204458|Caulobacterales	204458|Caulobacterales	G	Glycosyl hydrolase family 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_1
HKD2_k127_5128268_17	1089547.KB913013_gene4646	2.07e-43	164.0	COG2335@1|root,COG2335@2|Bacteria,4NMPI@976|Bacteroidetes,47XS3@768503|Cytophagia	976|Bacteroidetes	M	Four repeated domains in the Fasciclin I family of proteins, present in many other contexts.	-	-	-	-	-	-	-	-	-	-	-	-	Fasciclin
HKD2_k127_5128268_14	864702.OsccyDRAFT_0787	3.799e-65	233.0	COG0395@1|root,COG0395@2|Bacteria,1G1XU@1117|Cyanobacteria,1H8HR@1150|Oscillatoriales	1117|Cyanobacteria	G	PFAM Inward rectifier potassium channel	-	-	-	ko:K08715	-	-	-	-	ko00000,ko02000	1.A.2.2	-	-	IRK
HKD2_k127_5128268_24	1192034.CAP_7522	2.817e-11	70.0	2DHU7@1|root,300Z2@2|Bacteria,1Q940@1224|Proteobacteria,433U6@68525|delta/epsilon subdivisions,2X3GR@28221|Deltaproteobacteria,2YW0V@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	TPR_14
HKD2_k127_5128268_9	1254432.SCE1572_17990	2.565e-81	303.0	COG1413@1|root,COG3266@1|root,COG1413@2|Bacteria,COG3266@2|Bacteria,1QX4H@1224|Proteobacteria,42Z02@68525|delta/epsilon subdivisions,2WUJ9@28221|Deltaproteobacteria,2YVP1@29|Myxococcales	28221|Deltaproteobacteria	C	Type II secretion system (T2SS), protein E, N-terminal domain	frgA	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,T2SSE_N
HKD2_k127_5128268_25	1192034.CAP_4981	1.907e-08	64.0	COG2867@1|root,COG2867@2|Bacteria	2|Bacteria	I	negative regulation of translational initiation	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc,Polyketide_cyc2,START
HKD2_k127_5128268_19	73044.JNXP01000007_gene5383	3.071e-34	144.0	COG0698@1|root,COG0698@2|Bacteria,2IIDQ@201174|Actinobacteria	201174|Actinobacteria	G	Ribose 5-phosphate isomerase	-	-	5.3.1.6	ko:K01808	ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01056,R09030	RC00376,RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	LacAB_rpiB
HKD2_k127_5128268_21	448385.sce0648	8.142e-24	110.0	COG2885@1|root,COG2885@2|Bacteria,1QAG8@1224|Proteobacteria,4352E@68525|delta/epsilon subdivisions,2WZDB@28221|Deltaproteobacteria,2Z1W3@29|Myxococcales	28221|Deltaproteobacteria	M	Belongs to the ompA family	-	-	-	ko:K03640	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	OmpA
HKD2_k127_5128268_12	448385.sce0014	2.935e-67	239.0	COG0007@1|root,COG1587@1|root,COG0007@2|Bacteria,COG1587@2|Bacteria,1MUI0@1224|Proteobacteria,42MCB@68525|delta/epsilon subdivisions,2WIRJ@28221|Deltaproteobacteria,2YUYH@29|Myxococcales	28221|Deltaproteobacteria	H	Belongs to the precorrin methyltransferase family	hemD	-	1.3.1.76,2.1.1.107,4.2.1.75,4.99.1.4	ko:K02302,ko:K02303,ko:K13542	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02864,R03165,R03194,R03947	RC00003,RC00871,RC01012,RC01034,RC01861	ko00000,ko00001,ko00002,ko01000	-	-	-	HEM4,TP_methylase
HKD2_k127_5128853_14	448385.sce6452	4.556e-13	71.0	COG1826@1|root,COG1826@2|Bacteria	2|Bacteria	U	protein secretion	tatA	-	-	ko:K03116	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
HKD2_k127_5128853_16	448385.sce6452	8.041e-12	66.0	COG1826@1|root,COG1826@2|Bacteria	2|Bacteria	U	protein secretion	tatA	-	-	ko:K03116	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
HKD2_k127_5128853_1	448385.sce4477	4.576e-156	502.0	COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,42MKR@68525|delta/epsilon subdivisions,2WIS3@28221|Deltaproteobacteria,2YU6F@29|Myxococcales	28221|Deltaproteobacteria	E	Aminotransferase	aspB	-	2.6.1.1	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
HKD2_k127_5128853_10	671143.DAMO_1669	6.902e-22	112.0	COG0845@1|root,COG2010@1|root,COG0845@2|Bacteria,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,FIVAR,HlyD_3,PA14,RNA_pol_Rpb1_5
HKD2_k127_5128853_11	1183438.GKIL_4038	3.077e-18	100.0	COG4640@1|root,COG4640@2|Bacteria	2|Bacteria	KT	response to antibiotic	-	-	-	-	-	-	-	-	-	-	-	-	DUF3160,YARHG,zinc_ribbon_2
HKD2_k127_5128853_4	1254432.SCE1572_15425	1.145e-107	356.0	COG0602@1|root,COG0602@2|Bacteria,1MUJ2@1224|Proteobacteria,42RT9@68525|delta/epsilon subdivisions,2WNJ0@28221|Deltaproteobacteria,2YWKZ@29|Myxococcales	28221|Deltaproteobacteria	H	Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds	queE	-	4.3.99.3	ko:K10026	ko00790,ko01100,map00790,map01100	-	R10002	RC02989	ko00000,ko00001,ko01000,ko03016	-	-	iAF987.Gmet_1658	Fer4_14,Radical_SAM
HKD2_k127_5128853_12	452637.Oter_2380	6.966e-16	91.0	2ETF9@1|root,33KZ8@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF4412)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4412
HKD2_k127_5128853_5	945713.IALB_2637	1.139e-96	343.0	COG0158@1|root,COG0158@2|Bacteria	2|Bacteria	G	fructose 1,6-bisphosphate 1-phosphatase activity	fbp	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005984,GO:0005985,GO:0005986,GO:0005996,GO:0006000,GO:0006002,GO:0006006,GO:0006094,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009311,GO:0009312,GO:0009987,GO:0016043,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0019318,GO:0019319,GO:0019637,GO:0022607,GO:0030388,GO:0034637,GO:0042132,GO:0042578,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0046364,GO:0050308,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0071704,GO:0071840,GO:1901135,GO:1901576	3.1.3.11	ko:K03841	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko04152,ko04910,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map04152,map04910	M00003,M00165,M00167,M00344	R00762,R04780	RC00017	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iUTI89_1310.UTI89_C4836,ic_1306.c5329	FBPase
HKD2_k127_5128853_15	449447.MAE_14090	1.375e-12	80.0	COG3391@1|root,COG3391@2|Bacteria,1G499@1117|Cyanobacteria	1117|Cyanobacteria	S	NHL repeat	-	-	-	-	-	-	-	-	-	-	-	-	DUF5128,NHL,VPEP
HKD2_k127_5128853_6	502025.Hoch_2333	1.008e-56	221.0	COG3292@1|root,COG3292@2|Bacteria,1PCR9@1224|Proteobacteria,43E4V@68525|delta/epsilon subdivisions,2WZQV@28221|Deltaproteobacteria,2Z2J9@29|Myxococcales	28221|Deltaproteobacteria	T	Two component regulator propeller	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5128853_0	502025.Hoch_2332	4.994e-190	621.0	COG2304@1|root,COG2304@2|Bacteria,1MW8K@1224|Proteobacteria,42QVZ@68525|delta/epsilon subdivisions,2WMVN@28221|Deltaproteobacteria,2YUQR@29|Myxococcales	28221|Deltaproteobacteria	S	Vault protein inter-alpha-trypsin domain	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VIT,VWA_3
HKD2_k127_5128853_9	1121920.AUAU01000008_gene1679	2.013e-31	130.0	COG2329@1|root,COG2329@2|Bacteria,3Y8M6@57723|Acidobacteria	57723|Acidobacteria	S	Antibiotic biosynthesis monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5128853_3	1254432.SCE1572_15435	4.595e-147	474.0	COG1830@1|root,COG1830@2|Bacteria,1MW9N@1224|Proteobacteria,42PEB@68525|delta/epsilon subdivisions,2WM0Y@28221|Deltaproteobacteria,2Z349@29|Myxococcales	28221|Deltaproteobacteria	G	DeoC/LacD family aldolase	fbaB	-	4.1.2.13	ko:K11645	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	DeoC
HKD2_k127_5128853_13	237368.SCABRO_01210	5.312e-15	85.0	COG4099@1|root,COG4099@2|Bacteria,2IZGJ@203682|Planctomycetes	203682|Planctomycetes	M	COG0526, thiol-disulfide isomerase and thioredoxins	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_2,DLH,Esterase,PMT_2,Peptidase_S9
HKD2_k127_5128853_7	448385.sce1458	5.884e-49	195.0	COG2267@1|root,COG2267@2|Bacteria,1REM6@1224|Proteobacteria,42VM4@68525|delta/epsilon subdivisions,2WRYC@28221|Deltaproteobacteria,2Z398@29|Myxococcales	28221|Deltaproteobacteria	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
HKD2_k127_5128853_2	448385.sce6491	4.775e-148	475.0	COG1964@1|root,COG1964@2|Bacteria,1QE02@1224|Proteobacteria,42M4B@68525|delta/epsilon subdivisions,2WJDI@28221|Deltaproteobacteria,2YZG3@29|Myxococcales	28221|Deltaproteobacteria	S	4Fe-4S single cluster domain	-	-	-	ko:K06937	-	-	-	-	ko00000,ko01000	-	-	-	Fer4_12,Fer4_14,Radical_SAM
HKD2_k127_5130070_4	448385.sce3324	1.43e-72	265.0	COG1172@1|root,COG1172@2|Bacteria,1MX7D@1224|Proteobacteria,42QIH@68525|delta/epsilon subdivisions,2WIR8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057,ko:K10440	ko02010,map02010	M00212,M00221	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2,3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	BPD_transp_2
HKD2_k127_5130070_0	794903.OPIT5_17290	2.363e-128	445.0	COG1129@1|root,COG1129@2|Bacteria,46UQP@74201|Verrucomicrobia,3K90Q@414999|Opitutae	414999|Opitutae	G	ATPases associated with a variety of cellular activities	-	-	3.6.3.17	ko:K10441	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	ABC_tran
HKD2_k127_5130070_2	1254432.SCE1572_50535	5.933e-113	376.0	COG1879@1|root,COG1879@2|Bacteria,1MU95@1224|Proteobacteria	1224|Proteobacteria	G	Periplasmic binding protein LacI transcriptional regulator	alsB	-	-	ko:K10439	ko02010,ko02030,map02010,map02030	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	Peripla_BP_4
HKD2_k127_5130070_3	448385.sce5636	1.421e-87	307.0	COG0515@1|root,COG0515@2|Bacteria,1PJRR@1224|Proteobacteria	1224|Proteobacteria	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	DUF4384,PEGA,Pkinase,TPR_12
HKD2_k127_5130070_1	215803.DB30_8495	2.544e-126	412.0	COG1404@1|root,COG1404@2|Bacteria,1PEJJ@1224|Proteobacteria,438RE@68525|delta/epsilon subdivisions,2X3YD@28221|Deltaproteobacteria,2YXKA@29|Myxococcales	28221|Deltaproteobacteria	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
HKD2_k127_5130999_2	1179778.PMM47T1_00755	3.238e-139	462.0	COG2303@1|root,COG2303@2|Bacteria,1P9UF@1224|Proteobacteria,1RPS8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GMC_oxred_C,GMC_oxred_N
HKD2_k127_5130999_6	1179778.PMM47T1_00760	1.953e-12	73.0	2E23Q@1|root,32XB1@2|Bacteria,1N02I@1224|Proteobacteria	1224|Proteobacteria	S	Twin-arginine translocation pathway signal protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5130999_3	667632.KB890185_gene459	2.814e-91	306.0	COG4705@1|root,COG4705@2|Bacteria,1MVMJ@1224|Proteobacteria,2VJTM@28216|Betaproteobacteria,1K18G@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Repeat of Unknown Function (DUF347)	-	-	-	-	-	-	-	-	-	-	-	-	DUF347
HKD2_k127_5130999_1	404589.Anae109_3732	2.234e-149	482.0	COG1064@1|root,COG1064@2|Bacteria,1MUTT@1224|Proteobacteria,42MY6@68525|delta/epsilon subdivisions	1224|Proteobacteria	C	alcohol dehydrogenase	yjgB	-	1.1.1.1	ko:K00001,ko:K13953	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
HKD2_k127_5130999_0	1224136.AMFN01000003_gene3402	9.948e-208	657.0	COG1012@1|root,COG1012@2|Bacteria,1MXJ2@1224|Proteobacteria,1RPIA@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Aldehyde dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Aldedh
HKD2_k127_5130999_4	755732.Fluta_3017	2.712e-41	164.0	COG0526@1|root,COG0607@1|root,COG0526@2|Bacteria,COG0607@2|Bacteria,4NUPH@976|Bacteroidetes,1I51Q@117743|Flavobacteriia,2PC0A@246874|Cryomorphaceae	976|Bacteroidetes	COP	COGs COG0607 Rhodanese-related sulfurtransferase	glpE	-	-	-	-	-	-	-	-	-	-	-	Rhodanese,Thioredoxin
HKD2_k127_5130999_5	96561.Dole_0397	2.013e-31	130.0	29CZA@1|root,2ZZXB@2|Bacteria,1RFNE@1224|Proteobacteria,42TRV@68525|delta/epsilon subdivisions,2WR3X@28221|Deltaproteobacteria,2MKTT@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5131608_2	1254432.SCE1572_35915	1.283e-83	293.0	COG3220@1|root,COG3220@2|Bacteria,1MURE@1224|Proteobacteria,42SA5@68525|delta/epsilon subdivisions,2WNP1@28221|Deltaproteobacteria,2YXVS@29|Myxococcales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF692)	-	-	-	ko:K09930	-	-	-	-	ko00000	-	-	-	DUF692
HKD2_k127_5131608_5	1192034.CAP_8541	4.6e-42	163.0	COG3219@1|root,COG3220@1|root,COG3219@2|Bacteria,COG3220@2|Bacteria,1MURE@1224|Proteobacteria,42SA5@68525|delta/epsilon subdivisions,2WNP1@28221|Deltaproteobacteria,2YXVS@29|Myxococcales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF692)	-	-	-	ko:K09930	-	-	-	-	ko00000	-	-	-	DUF692
HKD2_k127_5131608_8	290397.Adeh_4218	2.434e-07	62.0	COG0671@1|root,COG0671@2|Bacteria,1RIRR@1224|Proteobacteria,42X79@68525|delta/epsilon subdivisions,2WXA0@28221|Deltaproteobacteria,2YVD9@29|Myxococcales	28221|Deltaproteobacteria	I	Acid phosphatase homologues	-	-	-	-	-	-	-	-	-	-	-	-	PAP2
HKD2_k127_5131608_1	448385.sce9085	2.663e-116	385.0	COG1262@1|root,COG1262@2|Bacteria,1R59H@1224|Proteobacteria	2|Bacteria	S	Sulfatase-modifying factor enzyme 1	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase,SapC
HKD2_k127_5131608_4	1192034.CAP_1769	6.773e-66	251.0	COG0515@1|root,COG0515@2|Bacteria	1192034.CAP_1769|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5131608_3	502025.Hoch_5059	3.079e-83	283.0	COG1028@1|root,COG1028@2|Bacteria,1MWGC@1224|Proteobacteria,42QH3@68525|delta/epsilon subdivisions,2WKXH@28221|Deltaproteobacteria,2YYMV@29|Myxococcales	28221|Deltaproteobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HKD2_k127_5131608_6	502025.Hoch_6055	1.969e-34	148.0	2AGE4@1|root,316JY@2|Bacteria,1PXQC@1224|Proteobacteria,434RK@68525|delta/epsilon subdivisions,2WZ2R@28221|Deltaproteobacteria,2Z17A@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5131608_0	404589.Anae109_1724	0.0	1429.0	COG1201@1|root,COG1201@2|Bacteria,1MUSW@1224|Proteobacteria,42Q75@68525|delta/epsilon subdivisions,2WMDY@28221|Deltaproteobacteria,2YU11@29|Myxococcales	28221|Deltaproteobacteria	L	DEAD DEAH box	-	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,Helicase_C
HKD2_k127_5136002_1	1254432.SCE1572_10955	1.517e-57	213.0	COG1502@1|root,COG1502@2|Bacteria,1NZKD@1224|Proteobacteria,430D2@68525|delta/epsilon subdivisions,2WVTD@28221|Deltaproteobacteria,2YV79@29|Myxococcales	28221|Deltaproteobacteria	I	PLD-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PLDc_2
HKD2_k127_5136002_2	448385.sce3387	2.007e-08	66.0	COG4447@1|root,COG4447@2|Bacteria,1R42J@1224|Proteobacteria,42WGC@68525|delta/epsilon subdivisions,2WRHI@28221|Deltaproteobacteria,2YVIP@29|Myxococcales	28221|Deltaproteobacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5136002_0	1192034.CAP_5909	1.827e-146	477.0	COG3291@1|root,COG3291@2|Bacteria,1QEIS@1224|Proteobacteria,4389M@68525|delta/epsilon subdivisions,2X3J1@28221|Deltaproteobacteria,2YWAB@29|Myxococcales	28221|Deltaproteobacteria	S	IgGFc binding protein	-	-	-	-	-	-	-	-	-	-	-	-	IgGFc_binding
HKD2_k127_5137532_0	1254432.SCE1572_34345	6.758e-252	799.0	COG0457@1|root,COG1672@1|root,COG0457@2|Bacteria,COG1672@2|Bacteria,1NB06@1224|Proteobacteria,43AS1@68525|delta/epsilon subdivisions,2X665@28221|Deltaproteobacteria,2YYB2@29|Myxococcales	28221|Deltaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,TPR_12,TPR_8
HKD2_k127_5140663_2	861299.J421_0232	1.35e-06	60.0	COG3055@1|root,COG3055@2|Bacteria,1ZUV8@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Galactose oxidase, central domain	-	-	-	-	-	-	-	-	-	-	-	-	Kelch_4
HKD2_k127_5140663_1	290397.Adeh_3740	3.459e-52	204.0	COG0515@1|root,COG0515@2|Bacteria	290397.Adeh_3740|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5140663_0	485913.Krac_7836	2.67e-101	335.0	COG1960@1|root,COG1960@2|Bacteria,2G7JH@200795|Chloroflexi	200795|Chloroflexi	C	PFAM acyl-CoA dehydrogenase domain protein	-	-	1.3.8.6	ko:K00252	ko00071,ko00310,ko00362,ko00380,ko01100,ko01120,ko01130,map00071,map00310,map00362,map00380,map01100,map01120,map01130	M00032	R02487,R02488,R10074	RC00052,RC00156	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HKD2_k127_5142960_0	96561.Dole_1944	4.026e-10	67.0	COG2067@1|root,COG2067@2|Bacteria,1RA6W@1224|Proteobacteria	1224|Proteobacteria	I	COG2067 Long-chain fatty acid transport protein	-	-	-	ko:K06076	-	-	-	-	ko00000,ko02000	1.B.9	-	-	Toluene_X
HKD2_k127_5150797_7	1254432.SCE1572_23445	2.383e-33	133.0	COG0805@1|root,COG0805@2|Bacteria,1MVAY@1224|Proteobacteria,42MM7@68525|delta/epsilon subdivisions,2WKJW@28221|Deltaproteobacteria,2YVGX@29|Myxococcales	28221|Deltaproteobacteria	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides	tatC	-	-	ko:K03118	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	TatC
HKD2_k127_5150797_9	1192034.CAP_6993	2.434e-25	112.0	COG1826@1|root,COG1826@2|Bacteria	2|Bacteria	U	protein secretion	tatB	GO:0003674,GO:0005215	-	ko:K03116,ko:K03117	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
HKD2_k127_5150797_1	1192034.CAP_6992	1.294e-112	373.0	COG0820@1|root,COG0820@2|Bacteria,1MUYK@1224|Proteobacteria,42N69@68525|delta/epsilon subdivisions,2WIUJ@28221|Deltaproteobacteria,2YWPQ@29|Myxococcales	28221|Deltaproteobacteria	J	Belongs to the radical SAM superfamily. RlmN family	-	-	2.1.1.192	ko:K06941	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Radical_SAM
HKD2_k127_5150797_2	1192034.CAP_6991	1.205e-102	348.0	COG2067@1|root,COG2067@2|Bacteria	2|Bacteria	I	long-chain fatty acid transporting porin activity	-	-	-	ko:K06076	-	-	-	-	ko00000,ko02000	1.B.9	-	-	Toluene_X
HKD2_k127_5150797_0	1254432.SCE1572_23420	4.13e-116	405.0	COG2067@1|root,COG2067@2|Bacteria,1P67N@1224|Proteobacteria	2|Bacteria	I	long-chain fatty acid transport protein	-	-	-	ko:K06076	-	-	-	-	ko00000,ko02000	1.B.9	-	-	Toluene_X
HKD2_k127_5150797_6	1192034.CAP_7113	3.78e-37	162.0	COG2152@1|root,COG2152@2|Bacteria	2|Bacteria	G	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_130,Glyco_hydro_32N,Glyco_hydro_43
HKD2_k127_5150797_4	1254432.SCE1572_21260	5.147e-68	257.0	COG0628@1|root,COG0628@2|Bacteria,1MXXU@1224|Proteobacteria,42P0U@68525|delta/epsilon subdivisions,2WJC6@28221|Deltaproteobacteria,2Z306@29|Myxococcales	28221|Deltaproteobacteria	S	Pfam:UPF0118	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
HKD2_k127_5150797_8	309801.trd_0313	2.319e-32	139.0	COG2339@1|root,COG2339@2|Bacteria,2GAFJ@200795|Chloroflexi,27Z8G@189775|Thermomicrobia	189775|Thermomicrobia	S	Protease prsW family	-	-	-	-	-	-	-	-	-	-	-	-	PrsW-protease
HKD2_k127_5150797_5	391625.PPSIR1_18737	1.943e-54	218.0	COG1572@1|root,COG1572@2|Bacteria,1R94M@1224|Proteobacteria	1224|Proteobacteria	NU	bacterial-type flagellum-dependent cell motility	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5150797_3	489825.LYNGBM3L_41540	3.505e-79	281.0	COG0395@1|root,COG0395@2|Bacteria,1G1XU@1117|Cyanobacteria,1H8HR@1150|Oscillatoriales	1117|Cyanobacteria	G	PFAM Inward rectifier potassium channel	-	-	-	ko:K08715	-	-	-	-	ko00000,ko02000	1.A.2.2	-	-	IRK
HKD2_k127_5150797_10	448385.sce2853	4.619e-23	98.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,42MK5@68525|delta/epsilon subdivisions,2WJ3Z@28221|Deltaproteobacteria,2YUET@29|Myxococcales	28221|Deltaproteobacteria	C	Acyl-CoA dehydrogenase, N-terminal domain	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HKD2_k127_5151240_4	1408419.JHYG01000004_gene1499	6.983e-37	142.0	COG0403@1|root,COG1003@1|root,COG0403@2|Bacteria,COG1003@2|Bacteria,1MUDP@1224|Proteobacteria,2TSFF@28211|Alphaproteobacteria,2JPMB@204441|Rhodospirillales	204441|Rhodospirillales	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvP	-	1.4.4.2	ko:K00281,ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko00002,ko01000	-	-	-	Aminotran_5,GDC-P
HKD2_k127_5151240_5	1254432.SCE1572_27660	6.826e-26	119.0	COG0457@1|root,COG0457@2|Bacteria,1Q2MT@1224|Proteobacteria,433UE@68525|delta/epsilon subdivisions,2X3I3@28221|Deltaproteobacteria,2YW6Y@29|Myxococcales	28221|Deltaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5151240_6	450851.PHZ_c3308	1.603e-06	56.0	COG1225@1|root,COG1225@2|Bacteria,1QXXA@1224|Proteobacteria,2VEPR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	AhpC/TSA family	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5151240_0	448385.sce4539	1.611e-129	435.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,42Q67@68525|delta/epsilon subdivisions,2WKZ1@28221|Deltaproteobacteria,2YUMV@29|Myxococcales	28221|Deltaproteobacteria	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HKD2_k127_5151240_1	502025.Hoch_0050	6.187e-92	328.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2YYJX@29|Myxococcales	28221|Deltaproteobacteria	T	response regulator	-	-	-	ko:K07714	ko02020,map02020	M00500	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD2_k127_5151240_2	1192034.CAP_0176	7.582e-43	171.0	COG1729@1|root,COG1729@2|Bacteria,1MX82@1224|Proteobacteria,42TQ9@68525|delta/epsilon subdivisions,2WR3B@28221|Deltaproteobacteria,2YUXH@29|Myxococcales	28221|Deltaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_6
HKD2_k127_5151240_3	33876.JNXY01000005_gene8844	6.035e-39	155.0	COG3831@1|root,COG3831@2|Bacteria,2HIEQ@201174|Actinobacteria,4D9WJ@85008|Micromonosporales	201174|Actinobacteria	S	Domain of unknown function (DUF4132)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4132
HKD2_k127_5160140_6	1192034.CAP_0344	1.028e-52	190.0	COG0848@1|root,COG0848@2|Bacteria,1N8FU@1224|Proteobacteria,42WU3@68525|delta/epsilon subdivisions,2WSMD@28221|Deltaproteobacteria,2YZRG@29|Myxococcales	28221|Deltaproteobacteria	U	Biopolymer transport protein ExbD/TolR	-	-	-	-	-	-	-	-	-	-	-	-	ExbD
HKD2_k127_5160140_4	1254432.SCE1572_18210	2.952e-73	250.0	COG0848@1|root,COG0848@2|Bacteria,1RENY@1224|Proteobacteria,42X3K@68525|delta/epsilon subdivisions,2WT0T@28221|Deltaproteobacteria,2YW1G@29|Myxococcales	28221|Deltaproteobacteria	U	Biopolymer transport protein ExbD/TolR	aglS	-	-	-	-	-	-	-	-	-	-	-	ExbD
HKD2_k127_5160140_5	1254432.SCE1572_18220	4.594e-58	219.0	COG2379@1|root,COG2379@2|Bacteria,1MVIK@1224|Proteobacteria,42Q1H@68525|delta/epsilon subdivisions,2WK7W@28221|Deltaproteobacteria,2YVDS@29|Myxococcales	28221|Deltaproteobacteria	G	PFAM MOFRL domain protein	-	-	2.7.1.165	ko:K11529	ko00030,ko00260,ko00561,ko00630,ko00680,ko01100,ko01120,ko01130,ko01200,map00030,map00260,map00561,map00630,map00680,map01100,map01120,map01130,map01200	M00346	R08572	RC00002,RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF4147,MOFRL
HKD2_k127_5160140_1	1254432.SCE1572_18230	1.191e-155	522.0	COG1078@1|root,COG1078@2|Bacteria,1R5S2@1224|Proteobacteria,42ZN2@68525|delta/epsilon subdivisions,2WV1K@28221|Deltaproteobacteria,2Z33S@29|Myxococcales	28221|Deltaproteobacteria	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	ko:K06885	-	-	-	-	ko00000	-	-	-	HD
HKD2_k127_5160140_8	1357399.HMPREF2087_01674	3.512e-48	190.0	COG2189@1|root,COG2189@2|Bacteria,1MX9M@1224|Proteobacteria,42PHQ@68525|delta/epsilon subdivisions,2YN47@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	L	DNA methylase	-	-	2.1.1.72	ko:K00571,ko:K07316	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
HKD2_k127_5160140_11	1437608.BBIA_1057	1.316e-05	57.0	COG3942@1|root,COG3942@2|Bacteria,2GZG8@201174|Actinobacteria,4CYQJ@85004|Bifidobacteriales	201174|Actinobacteria	D	CHAP domain protein	-	-	-	ko:K21471	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	CHAP
HKD2_k127_5160140_2	1192034.CAP_9007	6.641e-106	351.0	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,42NSM@68525|delta/epsilon subdivisions,2WJXQ@28221|Deltaproteobacteria,2YUS3@29|Myxococcales	28221|Deltaproteobacteria	V	ABC transporter, ATP-binding protein	pilH	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD2_k127_5160140_3	1254432.SCE1572_34400	1.022e-104	344.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2YTW0@29|Myxococcales	28221|Deltaproteobacteria	T	response regulator	-	-	-	ko:K02481,ko:K07713	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD2_k127_516029_3	743718.Isova_1228	7.311e-07	57.0	2EKAX@1|root,33E18@2|Bacteria,2GR20@201174|Actinobacteria,4F4SY@85017|Promicromonosporaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_516029_1	1192034.CAP_4649	1.478e-48	189.0	COG2931@1|root,COG2931@2|Bacteria,1PG5F@1224|Proteobacteria,43F2Q@68525|delta/epsilon subdivisions,2X35A@28221|Deltaproteobacteria,2YY8H@29|Myxococcales	28221|Deltaproteobacteria	Q	Parallel beta-helix repeats	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5165409_0	118166.JH976537_gene1650	1.738e-93	328.0	COG0366@1|root,COG3281@1|root,COG0366@2|Bacteria,COG3281@2|Bacteria,1G2UN@1117|Cyanobacteria,1H977@1150|Oscillatoriales	1117|Cyanobacteria	G	Alpha amylase, catalytic domain	-	-	3.2.1.1,5.4.99.16	ko:K05343	ko00500,ko01100,map00500,map01100	-	R01557,R02108,R02112,R11262	RC01816	ko00000,ko00001,ko01000	-	GH13	-	APH,Alpha-amylase,Malt_amylase_C
HKD2_k127_5165409_1	448385.sce8294	5.621e-90	301.0	COG0560@1|root,COG0560@2|Bacteria,1RA1A@1224|Proteobacteria,42TQ7@68525|delta/epsilon subdivisions,2WS2Q@28221|Deltaproteobacteria,2YXIZ@29|Myxococcales	28221|Deltaproteobacteria	E	haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD
HKD2_k127_5165409_2	861299.J421_1404	1.678e-43	169.0	COG0120@1|root,COG0120@2|Bacteria	2|Bacteria	G	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate	rpiA	GO:0003674,GO:0003824,GO:0004751,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006014,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009052,GO:0009117,GO:0009987,GO:0016853,GO:0016860,GO:0016861,GO:0019321,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046496,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564	2.7.1.12,2.7.1.15,5.3.1.6	ko:K00851,ko:K00852,ko:K01807	ko00030,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167,M00580	R01051,R01056,R01737,R02750	RC00002,RC00017,RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	Rib_5-P_isom_A
HKD2_k127_5167826_1	378806.STAUR_1138	2.686e-57	206.0	COG0475@1|root,COG0589@1|root,COG0475@2|Bacteria,COG0589@2|Bacteria,1MVGV@1224|Proteobacteria,42WJ6@68525|delta/epsilon subdivisions,2WQ9K@28221|Deltaproteobacteria,2YXTM@29|Myxococcales	28221|Deltaproteobacteria	PT	Sodium/hydrogen exchanger family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger,Usp
HKD2_k127_5167826_7	1321786.HMPREF1992_00065	1.134e-07	61.0	COG1584@1|root,COG1584@2|Bacteria,1TSYX@1239|Firmicutes,4H4MC@909932|Negativicutes	909932|Negativicutes	S	GPR1 FUN34 yaaH family protein	-	-	-	ko:K07034	-	-	-	-	ko00000	-	-	-	Grp1_Fun34_YaaH
HKD2_k127_5167826_6	1120949.KB903308_gene1221	4.216e-13	79.0	COG1309@1|root,COG1309@2|Bacteria,2IE9K@201174|Actinobacteria,4DJ0Q@85008|Micromonosporales	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
HKD2_k127_5167826_0	215803.DB30_4125	7.694e-92	314.0	COG0208@1|root,COG0208@2|Bacteria,1R4T3@1224|Proteobacteria,439AV@68525|delta/epsilon subdivisions,2X4IJ@28221|Deltaproteobacteria,2YZ3A@29|Myxococcales	28221|Deltaproteobacteria	F	COG0208 Ribonucleotide reductase, beta subunit	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5167826_3	526227.Mesil_1589	1.724e-51	192.0	COG1121@1|root,COG1121@2|Bacteria,1WIBF@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	P	COG1121 ABC-type Mn Zn transport systems ATPase component	-	-	-	ko:K09817	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	ABC_tran
HKD2_k127_5167826_2	987059.RBXJA2T_15068	3.213e-56	226.0	COG2367@1|root,COG2367@2|Bacteria,1NMW4@1224|Proteobacteria,2VP9F@28216|Betaproteobacteria,1KNHM@119065|unclassified Burkholderiales	28216|Betaproteobacteria	V	Beta-lactamase	bla	-	3.5.2.6	ko:K17836	ko00311,ko01130,ko01501,map00311,map01130,map01501	M00627,M00628	R06363	RC01499	ko00000,ko00001,ko00002,ko01000,ko01504	-	-	-	Beta-lactamase2
HKD2_k127_5168264_0	1254432.SCE1572_14730	1.925e-77	284.0	COG2378@1|root,COG2378@2|Bacteria,1RBK8@1224|Proteobacteria,42R5D@68525|delta/epsilon subdivisions,2WN2E@28221|Deltaproteobacteria,2Z2CD@29|Myxococcales	28221|Deltaproteobacteria	K	WYL domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_11,WYL
HKD2_k127_5168264_1	448385.sce2436	3.042e-70	242.0	COG0213@1|root,COG0213@2|Bacteria,1MV3H@1224|Proteobacteria,42PCD@68525|delta/epsilon subdivisions,2WKGQ@28221|Deltaproteobacteria,2YU9M@29|Myxococcales	28221|Deltaproteobacteria	F	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis	pdp	-	2.4.2.2,2.4.2.4	ko:K00756,ko:K00758	ko00240,ko00983,ko01100,ko05219,map00240,map00983,map01100,map05219	-	R01570,R01876,R02296,R02484,R08222,R08230	RC00063	ko00000,ko00001,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3,PYNP_C
HKD2_k127_5169354_5	1313421.JHBV01000003_gene661	2.84e-27	114.0	COG3239@1|root,COG3239@2|Bacteria,4NHPQ@976|Bacteroidetes,1IQQX@117747|Sphingobacteriia	976|Bacteroidetes	I	PFAM Fatty acid desaturase	-	-	-	-	-	-	-	-	-	-	-	-	FA_desaturase
HKD2_k127_5169354_1	1192034.CAP_4905	2.399e-105	353.0	COG1404@1|root,COG1404@2|Bacteria	2|Bacteria	O	Belongs to the peptidase S8 family	-	-	-	ko:K17734	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S8
HKD2_k127_5169354_3	1144275.COCOR_07994	9.904e-33	136.0	COG0204@1|root,COG0204@2|Bacteria,1RB47@1224|Proteobacteria,43103@68525|delta/epsilon subdivisions,2WX42@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	Phosphate acyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Acyltransferase,DAGAT
HKD2_k127_5169354_7	909943.HIMB100_00014290	9.871e-12	72.0	COG0652@1|root,COG0652@2|Bacteria,1R9ZQ@1224|Proteobacteria,2U591@28211|Alphaproteobacteria,4BQ68@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	ppiA	-	5.2.1.8	ko:K01802,ko:K03767,ko:K03768,ko:K09565	ko01503,ko04020,ko04022,ko04217,ko05012,ko05016,ko05145,map01503,map04020,map04022,map04217,map05012,map05016,map05145	-	-	-	ko00000,ko00001,ko01000,ko03110,ko04147	-	-	-	Pro_isomerase
HKD2_k127_5169354_6	1144275.COCOR_05093	1.488e-18	100.0	COG2267@1|root,COG2267@2|Bacteria,1N59S@1224|Proteobacteria	1224|Proteobacteria	I	carboxylic ester hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4
HKD2_k127_5169354_0	448385.sce1638	1.163e-136	443.0	COG3138@1|root,COG3138@2|Bacteria,1MWHC@1224|Proteobacteria,42SUP@68525|delta/epsilon subdivisions,2WPBD@28221|Deltaproteobacteria,2YU07@29|Myxococcales	28221|Deltaproteobacteria	E	N-succinyltransferase beta subunit	astA	-	2.3.1.109	ko:K00673	ko00330,ko01100,map00330,map01100	-	R00832	RC00004,RC00064	ko00000,ko00001,ko01000	-	-	-	AstA
HKD2_k127_5169354_4	1192034.CAP_1876	5.304e-30	134.0	COG4402@1|root,COG4402@2|Bacteria	2|Bacteria	S	Uncharacterized protein conserved in bacteria (DUF2330)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2330
HKD2_k127_5169354_2	1121382.JQKG01000005_gene3323	1.747e-50	192.0	COG0803@1|root,COG0803@2|Bacteria,1WI8I@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	P	Belongs to the bacterial solute-binding protein 9 family	-	-	-	ko:K09815	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	ZnuA
HKD2_k127_5172503_2	1144275.COCOR_01443	8.3e-132	424.0	COG0842@1|root,COG0842@2|Bacteria,1MUIA@1224|Proteobacteria,43AEH@68525|delta/epsilon subdivisions,2WIU2@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	PFAM ABC-2 type transporter	yhhJ	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
HKD2_k127_5172503_3	196490.AUEZ01000001_gene7503	1.473e-119	400.0	COG2326@1|root,COG2326@2|Bacteria,1MVE2@1224|Proteobacteria,2TSU8@28211|Alphaproteobacteria,3JRKK@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Polyphosphate kinase 2 (PPK2)	-	-	2.7.4.1	ko:K22468	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PPK2
HKD2_k127_5172503_4	113395.AXAI01000038_gene118	8.557e-43	175.0	COG3148@1|root,COG3148@2|Bacteria,1MZCN@1224|Proteobacteria,2U1C3@28211|Alphaproteobacteria,3JR4C@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	DTW	MA20_30020	-	-	ko:K05812	-	-	-	-	ko00000	-	-	-	DTW
HKD2_k127_5172503_0	448385.sce8085	1.169e-186	601.0	COG0370@1|root,COG0370@2|Bacteria,1MUZC@1224|Proteobacteria,42MCY@68525|delta/epsilon subdivisions,2WIWJ@28221|Deltaproteobacteria,2YYYV@29|Myxococcales	28221|Deltaproteobacteria	P	transporter of a GTP-driven Fe(2 ) uptake system	feoB	-	-	ko:K04759	-	-	-	-	ko00000,ko02000	9.A.8.1	-	-	FeoB_C,FeoB_N,Gate
HKD2_k127_5172503_5	448385.sce8084	2.369e-07	57.0	COG1918@1|root,COG1918@2|Bacteria	2|Bacteria	P	iron ion homeostasis	feoA	-	-	ko:K04758	-	-	-	-	ko00000,ko02000	-	-	-	FeoA
HKD2_k127_5172503_1	1254432.SCE1572_33325	3.672e-149	494.0	COG0515@1|root,COG1262@1|root,COG0515@2|Bacteria,COG1262@2|Bacteria,1MZ25@1224|Proteobacteria,42PUT@68525|delta/epsilon subdivisions,2WKN0@28221|Deltaproteobacteria,2YVT8@29|Myxococcales	28221|Deltaproteobacteria	KLT	Sulfatase-modifying factor enzyme 1	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	FGE-sulfatase,Pkinase
HKD2_k127_5180071_2	1254432.SCE1572_28445	3.532e-44	175.0	28H8R@1|root,2Z7KJ@2|Bacteria,1Q390@1224|Proteobacteria,43905@68525|delta/epsilon subdivisions,2X457@28221|Deltaproteobacteria,2YYAC@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5180071_5	448385.sce1644	9.753e-27	119.0	COG1191@1|root,COG1191@2|Bacteria,1Q2IP@1224|Proteobacteria,4385G@68525|delta/epsilon subdivisions,2X9Y3@28221|Deltaproteobacteria,2YVUY@29|Myxococcales	28221|Deltaproteobacteria	K	Belongs to the sigma-70 factor family	-	-	-	ko:K02405	ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111	-	-	-	ko00000,ko00001,ko02035,ko03021	-	-	-	Sigma70_r2,Sigma70_r4
HKD2_k127_5180071_1	448385.sce7297	5.541e-130	424.0	COG0482@1|root,COG0482@2|Bacteria,1MUT1@1224|Proteobacteria,42MZR@68525|delta/epsilon subdivisions,2WK6B@28221|Deltaproteobacteria,2YUTU@29|Myxococcales	28221|Deltaproteobacteria	J	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34	mnmA	-	2.8.1.13	ko:K00566	ko04122,map04122	-	R08700	RC02313,RC02315	ko00000,ko00001,ko01000,ko03016	-	-	-	tRNA_Me_trans
HKD2_k127_5180071_7	394221.Mmar10_0874	0.0005479	52.0	COG0457@1|root,COG0457@2|Bacteria,1MVCA@1224|Proteobacteria,2UAC1@28211|Alphaproteobacteria,43WT7@69657|Hyphomonadaceae	28211|Alphaproteobacteria	S	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_7,TPR_8
HKD2_k127_5180071_0	1192034.CAP_4568	5.749e-159	512.0	COG0515@1|root,COG0515@2|Bacteria,1Q2R6@1224|Proteobacteria,433VB@68525|delta/epsilon subdivisions,2X3MY@28221|Deltaproteobacteria,2YWK6@29|Myxococcales	28221|Deltaproteobacteria	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HKD2_k127_518229_4	867903.ThesuDRAFT_02095	4.817e-20	96.0	COG0725@1|root,COG0725@2|Bacteria,1U9U3@1239|Firmicutes,249VA@186801|Clostridia,3WD7Q@538999|Clostridiales incertae sedis	186801|Clostridia	P	TIGRFAM molybdenum ABC transporter, periplasmic molybdate-binding protein	modA	-	-	ko:K02020	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.8	-	iHN637.CLJU_RS12820	SBP_bac_11
HKD2_k127_518229_3	1235279.C772_02753	9.442e-34	144.0	COG4149@1|root,COG4149@2|Bacteria,1TRNA@1239|Firmicutes,4HEA2@91061|Bacilli,26EAF@186818|Planococcaceae	91061|Bacilli	P	Molybdenum ABC transporter, permease	modB	-	-	ko:K02018	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.8	-	-	BPD_transp_1
HKD2_k127_518229_2	1121861.KB899919_gene2697	1.067e-36	156.0	COG4148@1|root,COG4148@2|Bacteria,1MU8K@1224|Proteobacteria,2TR1Z@28211|Alphaproteobacteria,2JQNZ@204441|Rhodospirillales	204441|Rhodospirillales	P	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system	modC	-	3.6.3.29	ko:K02017	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.8	-	-	ABC_tran,TOBE
HKD2_k127_518229_1	1254432.SCE1572_14520	1.083e-39	153.0	COG0521@1|root,COG0521@2|Bacteria,1R9W2@1224|Proteobacteria,42PGH@68525|delta/epsilon subdivisions,2X5KD@28221|Deltaproteobacteria,2Z362@29|Myxococcales	28221|Deltaproteobacteria	H	May be involved in the biosynthesis of molybdopterin	-	-	2.7.7.75	ko:K03638	ko00790,ko01100,map00790,map01100	-	R09726	RC00002	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth
HKD2_k127_518229_0	1254432.SCE1572_09600	1.6e-94	335.0	COG0249@1|root,COG0249@2|Bacteria,1N9K4@1224|Proteobacteria,42ZN5@68525|delta/epsilon subdivisions,2WUW7@28221|Deltaproteobacteria,2YTSE@29|Myxococcales	28221|Deltaproteobacteria	L	ATPase domain of DNA mismatch repair MUTS family	-	-	-	-	-	-	-	-	-	-	-	-	MutS_III,MutS_V
HKD2_k127_5190033_6	1254432.SCE1572_43085	2.2e-21	96.0	COG0760@1|root,COG0760@2|Bacteria,1Q4IW@1224|Proteobacteria,43A0D@68525|delta/epsilon subdivisions,2X2FD@28221|Deltaproteobacteria,2Z2B6@29|Myxococcales	28221|Deltaproteobacteria	M	PPIC-type PPIASE domain	-	-	-	-	-	-	-	-	-	-	-	-	Rotamase_3
HKD2_k127_5190033_2	768671.ThimaDRAFT_4798	2.268e-64	233.0	2C3WA@1|root,2Z8P1@2|Bacteria,1R8VC@1224|Proteobacteria,1S5UD@1236|Gammaproteobacteria,1WZ6R@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5190033_3	391008.Smal_2109	1.261e-46	181.0	COG2365@1|root,COG2365@2|Bacteria,1R4XF@1224|Proteobacteria,1TCM2@1236|Gammaproteobacteria,1X8US@135614|Xanthomonadales	135614|Xanthomonadales	T	Tyrosine phosphatase family	-	-	-	-	-	-	-	-	-	-	-	-	Y_phosphatase3
HKD2_k127_5190033_5	391625.PPSIR1_07445	6.468e-34	145.0	COG3137@1|root,COG3137@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K07283	-	-	-	-	ko00000	-	-	-	DUF481
HKD2_k127_5190033_1	1250232.JQNJ01000001_gene2791	3.747e-89	306.0	COG3865@1|root,COG3865@2|Bacteria,4NE70@976|Bacteroidetes,1HZR2@117743|Flavobacteriia	976|Bacteroidetes	S	3-demethylubiquinone-9 3-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	3-dmu-9_3-mt
HKD2_k127_5190033_4	290397.Adeh_0445	2.539e-36	152.0	COG5592@1|root,COG5592@2|Bacteria	2|Bacteria	I	hemerythrin HHE cation binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin,Phasin_2
HKD2_k127_5190033_0	1278073.MYSTI_02920	7.352e-111	367.0	COG0026@1|root,COG0026@2|Bacteria,1MU70@1224|Proteobacteria,42PQI@68525|delta/epsilon subdivisions,2WKZR@28221|Deltaproteobacteria,2YUAG@29|Myxococcales	28221|Deltaproteobacteria	F	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)	purK	-	6.3.4.18	ko:K01589	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07404	RC01927	ko00000,ko00001,ko00002,ko01000	-	-	-	2-Hacid_dh_C,ATP-grasp
HKD2_k127_5195417_0	1192034.CAP_6559	2.679e-92	323.0	COG2303@1|root,COG2303@2|Bacteria,1P9UF@1224|Proteobacteria,43A4M@68525|delta/epsilon subdivisions,2WYKE@28221|Deltaproteobacteria,2Z0NN@29|Myxococcales	1224|Proteobacteria	E	GMC oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GMC_oxred_C,GMC_oxred_N
HKD2_k127_5196577_4	667632.KB890182_gene876	5.798e-102	351.0	COG1520@1|root,COG1520@2|Bacteria,1NDU1@1224|Proteobacteria,2WBCG@28216|Betaproteobacteria,1K4V0@119060|Burkholderiaceae	1224|Proteobacteria	S	Pyrrolo-quinoline quinone	-	-	-	-	-	-	-	-	-	-	-	-	PQQ,PQQ_3
HKD2_k127_5196577_15	1192034.CAP_4102	4.182e-10	68.0	2BQRM@1|root,32JN9@2|Bacteria,1PDHV@1224|Proteobacteria,435GS@68525|delta/epsilon subdivisions,2WZUA@28221|Deltaproteobacteria,2Z2RV@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5196577_16	502025.Hoch_4700	2.714e-08	63.0	COG3809@1|root,COG3809@2|Bacteria,1QJZM@1224|Proteobacteria,43E52@68525|delta/epsilon subdivisions,2X98E@28221|Deltaproteobacteria,2Z2KB@29|Myxococcales	28221|Deltaproteobacteria	S	Transcription factor zinc-finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-TFIIB
HKD2_k127_5196577_0	448385.sce7413	1.617e-199	648.0	COG1033@1|root,COG1033@2|Bacteria,1R0DR@1224|Proteobacteria	1224|Proteobacteria	S	MMPL family	-	-	-	-	-	-	-	-	-	-	-	-	MMPL
HKD2_k127_5196577_7	562970.Btus_0302	8.238e-83	294.0	COG1253@1|root,COG1253@2|Bacteria,1TPN0@1239|Firmicutes,4H9SB@91061|Bacilli,277VB@186823|Alicyclobacillaceae	91061|Bacilli	S	Transporter associated domain	corC1	-	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
HKD2_k127_5196577_17	543632.JOJL01000003_gene8453	0.0002569	51.0	2EGCD@1|root,33A46@2|Bacteria,2GIVH@201174|Actinobacteria	201174|Actinobacteria	S	Septum formation	-	-	-	-	-	-	-	-	-	-	-	-	DUF4190,Septum_form
HKD2_k127_5196577_13	63737.Npun_R1214	1.756e-24	116.0	COG0346@1|root,COG0346@2|Bacteria,1GHQQ@1117|Cyanobacteria,1HPG9@1161|Nostocales	1117|Cyanobacteria	C	PFAM Glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HKD2_k127_5196577_8	639282.DEFDS_0915	1.285e-57	221.0	COG1838@1|root,COG1838@2|Bacteria,2GF6R@200930|Deferribacteres	200930|Deferribacteres	C	Fumarase C-terminus	-	-	4.2.1.2	ko:K01676	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumerase_C
HKD2_k127_5196577_5	639282.DEFDS_0916	4.894e-87	302.0	COG1951@1|root,COG1951@2|Bacteria,2GER7@200930|Deferribacteres	200930|Deferribacteres	C	Fumarate hydratase (Fumerase)	-	-	4.2.1.2	ko:K01676	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumerase
HKD2_k127_5196577_2	246197.MXAN_7310	5.122e-127	410.0	COG1028@1|root,COG1028@2|Bacteria,1MUSQ@1224|Proteobacteria,42YTV@68525|delta/epsilon subdivisions,2WTY1@28221|Deltaproteobacteria,2YYUF@29|Myxococcales	28221|Deltaproteobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	ko:K13775	ko00281,map00281	-	R08087,R08096,R10125,R10126	RC00080,RC00087	ko00000,ko00001	-	-	-	adh_short
HKD2_k127_5196577_9	392500.Swoo_3876	6.142e-47	175.0	2BTRP@1|root,32NYW@2|Bacteria,1RM2G@1224|Proteobacteria,1S7PH@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5196577_11	1254432.SCE1572_02855	3.516e-32	146.0	COG1512@1|root,COG1512@2|Bacteria,1PB41@1224|Proteobacteria,42R0Q@68525|delta/epsilon subdivisions,2WN87@28221|Deltaproteobacteria,2YW48@29|Myxococcales	28221|Deltaproteobacteria	S	TPM domain	-	-	-	ko:K06872	-	-	-	-	ko00000	-	-	-	TPM_phosphatase
HKD2_k127_5196577_3	448385.sce6155	2.403e-104	366.0	COG0457@1|root,COG0741@1|root,COG0457@2|Bacteria,COG0741@2|Bacteria,1MV3F@1224|Proteobacteria,42N7A@68525|delta/epsilon subdivisions,2WQFJ@28221|Deltaproteobacteria,2YV3N@29|Myxococcales	28221|Deltaproteobacteria	M	Transglycosylase SLT domain	-	-	-	ko:K08309	-	-	-	-	ko00000,ko01000,ko01011	-	GH23	-	SLT,SLT_L,TPR_16,TPR_6
HKD2_k127_5196577_10	1340493.JNIF01000004_gene660	2.145e-41	174.0	COG0515@1|root,COG1262@1|root,COG0515@2|Bacteria,COG1262@2|Bacteria	2|Bacteria	T	PFAM Formylglycine-generating sulfatase enzyme	egtB	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0006082,GO:0006520,GO:0006547,GO:0006548,GO:0006575,GO:0006577,GO:0006578,GO:0006725,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009987,GO:0016053,GO:0016054,GO:0016491,GO:0019439,GO:0019752,GO:0034641,GO:0042398,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044272,GO:0044281,GO:0044282,GO:0044283,GO:0046394,GO:0046395,GO:0046483,GO:0046700,GO:0046872,GO:0046914,GO:0052698,GO:0052699,GO:0052701,GO:0052703,GO:0052704,GO:0052708,GO:0052803,GO:0052805,GO:0055114,GO:0071704,GO:0097164,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606	1.14.99.50,2.7.11.1	ko:K12132,ko:K18912	ko00340,map00340	-	R11013	RC03323,RC03324	ko00000,ko00001,ko01000,ko01001	-	-	-	DinB_2,FGE-sulfatase
HKD2_k127_5196577_6	324925.Ppha_0342	3.478e-85	301.0	COG2189@1|root,COG2189@2|Bacteria	2|Bacteria	L	Belongs to the N(4) N(6)-methyltransferase family	-	-	2.1.1.72	ko:K07316	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
HKD2_k127_5196577_14	535289.Dtpsy_1821	3.622e-22	107.0	COG0517@1|root,COG0517@2|Bacteria,1QTWY@1224|Proteobacteria,2VTYW@28216|Betaproteobacteria,4AF94@80864|Comamonadaceae	28216|Betaproteobacteria	S	PFAM CBS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CBS
HKD2_k127_5196577_12	1110697.NCAST_08_02130	7.349e-26	109.0	2DJKR@1|root,32YT5@2|Bacteria,2I86F@201174|Actinobacteria,4G3NS@85025|Nocardiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5196577_1	1254432.SCE1572_43150	3.631e-168	541.0	COG0661@1|root,COG0661@2|Bacteria,1MW1J@1224|Proteobacteria,43B1W@68525|delta/epsilon subdivisions,2X6FY@28221|Deltaproteobacteria,2Z05P@29|Myxococcales	28221|Deltaproteobacteria	S	ABC1 family	-	-	-	-	-	-	-	-	-	-	-	-	ABC1
HKD2_k127_5199909_6	1254432.SCE1572_20325	4.184e-97	327.0	COG3766@1|root,COG3766@2|Bacteria	2|Bacteria	E	membrane	-	-	-	ko:K08989	-	-	-	-	ko00000	-	-	-	DUF350
HKD2_k127_5199909_1	448385.sce3342	5.568e-161	530.0	COG0754@1|root,COG0754@2|Bacteria	2|Bacteria	E	glutathionylspermidine amidase activity	gsp	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008884,GO:0008885,GO:0016787,GO:0016810,GO:0016811,GO:0016874,GO:0016879,GO:0016880,GO:0044424,GO:0044444,GO:0044464	3.5.1.78,6.3.1.8	ko:K01460	ko00480,ko01100,map00480,map01100	-	R01917,R01918	RC00090,RC00096	ko00000,ko00001,ko01000	-	-	iECIAI39_1322.ECIAI39_3484	CHAP,GSP_synth
HKD2_k127_5199909_5	448385.sce3300	2.482e-102	343.0	COG4638@1|root,COG4638@2|Bacteria,1MWXW@1224|Proteobacteria,4344K@68525|delta/epsilon subdivisions,2X57D@28221|Deltaproteobacteria,2Z07Z@29|Myxococcales	28221|Deltaproteobacteria	P	phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases large terminal subunit	-	-	1.14.15.7	ko:K00479,ko:K00499	ko00260,map00260	-	R07409	RC00087	ko00000,ko00001,ko01000	-	-	-	Rieske,Ring_hydroxyl_A
HKD2_k127_5199909_0	1254432.SCE1572_46935	2.972e-261	835.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,42M2R@68525|delta/epsilon subdivisions,2WJ4J@28221|Deltaproteobacteria,2YX0C@29|Myxococcales	28221|Deltaproteobacteria	P	Heavy-metal-associated domain	-	-	3.6.3.4,3.6.3.54	ko:K01533,ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
HKD2_k127_5199909_8	1336243.JAEA01000006_gene490	1.785e-64	227.0	COG3285@1|root,COG3285@2|Bacteria,1MVWY@1224|Proteobacteria,2TRSZ@28211|Alphaproteobacteria,1JXNH@119045|Methylobacteriaceae	28211|Alphaproteobacteria	L	DNA polymerase Ligase (LigD)	-	-	6.5.1.1	ko:K01971	ko03450,map03450	-	R00381	RC00005	ko00000,ko00001,ko01000,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,LigD_N
HKD2_k127_5199909_7	1254432.SCE1572_15910	1.432e-89	304.0	COG1273@1|root,COG1273@2|Bacteria,1N4UX@1224|Proteobacteria,42RD5@68525|delta/epsilon subdivisions,2WMZ1@28221|Deltaproteobacteria,2YV5B@29|Myxococcales	28221|Deltaproteobacteria	L	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD	ku	-	-	ko:K10979	ko03450,map03450	-	-	-	ko00000,ko00001,ko03400	-	-	-	Ku
HKD2_k127_5199909_12	762376.AXYL_05975	2.786e-10	70.0	COG3652@1|root,COG3652@2|Bacteria,1RDPI@1224|Proteobacteria,2VRQA@28216|Betaproteobacteria,3T798@506|Alcaligenaceae	28216|Betaproteobacteria	S	Domain of unknown function (DUF4142)	-	-	-	ko:K08995	-	-	-	-	ko00000	-	-	-	DUF4142
HKD2_k127_5199909_10	1254432.SCE1572_28315	3.436e-32	132.0	COG1975@1|root,COG2068@1|root,COG1975@2|Bacteria,COG2068@2|Bacteria,1MXKU@1224|Proteobacteria,42QUY@68525|delta/epsilon subdivisions,2WMVP@28221|Deltaproteobacteria,2YWIQ@29|Myxococcales	28221|Deltaproteobacteria	O	XdhC Rossmann domain	-	-	-	ko:K07402	-	-	-	-	ko00000	-	-	-	NTP_transf_3,XdhC_C,XdhC_CoxI
HKD2_k127_5201147_7	864702.OsccyDRAFT_1556	3.298e-11	64.0	COG3677@1|root,COG3677@2|Bacteria,1GEJ0@1117|Cyanobacteria	1117|Cyanobacteria	L	PFAM Insertion element protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Tnp_IS1,Zn_Tnp_IS1
HKD2_k127_5201147_6	105559.Nwat_1385	9.521e-12	66.0	COG3677@1|root,COG3677@2|Bacteria,1NP8S@1224|Proteobacteria,1SDQB@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	PFAM Insertion element protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Tnp_IS1,Zn_Tnp_IS1
HKD2_k127_5201147_8	314278.NB231_12054	4.287e-07	53.0	COG5659@1|root,COG5659@2|Bacteria,1MWAV@1224|Proteobacteria,1S12Y@1236|Gammaproteobacteria,1X271@135613|Chromatiales	135613|Chromatiales	L	COG5659 FOG Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5
HKD2_k127_5201147_4	596151.DesfrDRAFT_2128	1.004e-26	111.0	COG3328@1|root,COG3328@2|Bacteria,1MU4P@1224|Proteobacteria,42S30@68525|delta/epsilon subdivisions,2WQ5S@28221|Deltaproteobacteria,2MAPP@213115|Desulfovibrionales	28221|Deltaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_mut
HKD2_k127_5201147_0	1278073.MYSTI_04720	2.747e-120	402.0	COG0531@1|root,COG0531@2|Bacteria,1NRYF@1224|Proteobacteria,43DN8@68525|delta/epsilon subdivisions,2X6GY@28221|Deltaproteobacteria,2Z3B2@29|Myxococcales	28221|Deltaproteobacteria	E	Amino acid permease	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
HKD2_k127_5201147_5	512565.AMIS_65380	1.987e-15	90.0	COG5184@1|root,COG5184@2|Bacteria,2IG31@201174|Actinobacteria,4DA30@85008|Micromonosporales	201174|Actinobacteria	DZ	Alpha-tubulin suppressor and related RCC1 domain-containing proteins	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_5,CW_binding_2,RCC1,RCC1_2
HKD2_k127_5201147_2	1029823.AFIE01000056_gene569	2.546e-43	180.0	28Q1W@1|root,2ZCK4@2|Bacteria,1RE1D@1224|Proteobacteria,1T19A@1236|Gammaproteobacteria,3NKYR@468|Moraxellaceae	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5201147_3	1192034.CAP_1199	4.217e-31	134.0	COG4700@1|root,COG4700@2|Bacteria	2|Bacteria	T	PFAM Protein kinase domain	-	-	-	ko:K08309	-	-	-	-	ko00000,ko01000,ko01011	-	GH23	-	PLDc_N,TPR_16,TPR_19,TPR_4,TPR_6,TPR_8
HKD2_k127_5201147_1	1192034.CAP_6921	1.311e-87	312.0	COG0515@1|root,COG0515@2|Bacteria,1PFJ6@1224|Proteobacteria,4340Z@68525|delta/epsilon subdivisions,2X4J2@28221|Deltaproteobacteria,2YZ45@29|Myxococcales	28221|Deltaproteobacteria	KLT	Protein kinase domain	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
HKD2_k127_5201147_9	1192034.CAP_2185	1.617e-05	55.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	HYR,HtaA,Neocarzinostat
HKD2_k127_5212371_2	1144275.COCOR_01445	2.115e-27	112.0	COG0845@1|root,COG0845@2|Bacteria,1MUG6@1224|Proteobacteria,42NC1@68525|delta/epsilon subdivisions,2WMKG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Biotin-lipoyl like	-	-	-	ko:K01993	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
HKD2_k127_5212371_0	1144275.COCOR_01444	0.0	1367.0	COG0842@1|root,COG1129@1|root,COG0842@2|Bacteria,COG1129@2|Bacteria,1QTT9@1224|Proteobacteria,43BJ5@68525|delta/epsilon subdivisions,2X713@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	PFAM ABC transporter	-	-	-	ko:K01990,ko:K13926	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3,ABC_tran
HKD2_k127_5212371_1	1144275.COCOR_01443	2.552e-87	291.0	COG0842@1|root,COG0842@2|Bacteria,1MUIA@1224|Proteobacteria,43AEH@68525|delta/epsilon subdivisions,2WIU2@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	PFAM ABC-2 type transporter	yhhJ	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
HKD2_k127_5213416_1	1334046.AYTB01000009_gene2065	1.09e-21	104.0	COG0639@1|root,COG0639@2|Bacteria,1V1HN@1239|Firmicutes,4HG6T@91061|Bacilli,26FBI@186818|Planococcaceae	91061|Bacilli	T	Calcineurin-like phosphoesterase	pphA	-	3.1.3.16	ko:K07313	-	-	-	-	ko00000,ko01000	-	-	-	Metallophos
HKD2_k127_5213416_0	448385.sce7050	3.913e-104	351.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,42RC9@68525|delta/epsilon subdivisions,2WN5U@28221|Deltaproteobacteria,2YWJ8@29|Myxococcales	28221|Deltaproteobacteria	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HKD2_k127_5219191_0	1297742.A176_04954	1.357e-157	502.0	COG0495@1|root,COG0495@2|Bacteria,1MV47@1224|Proteobacteria,42MRQ@68525|delta/epsilon subdivisions,2WJ3E@28221|Deltaproteobacteria,2YU4U@29|Myxococcales	28221|Deltaproteobacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
HKD2_k127_5224309_2	1192034.CAP_1903	1.374e-139	478.0	COG3419@1|root,COG3419@2|Bacteria,1NUAV@1224|Proteobacteria,42NJ7@68525|delta/epsilon subdivisions,2WJYB@28221|Deltaproteobacteria,2YW3S@29|Myxococcales	28221|Deltaproteobacteria	NU	Tfp pilus assembly protein tip-associated adhesin	-	-	-	ko:K02674	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	Neisseria_PilC
HKD2_k127_5224309_21	349521.HCH_00961	4.508e-07	61.0	COG3391@1|root,COG3391@2|Bacteria,1RJQF@1224|Proteobacteria,1S6KV@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5224309_10	926566.Terro_1937	8.697e-83	301.0	COG2374@1|root,COG2374@2|Bacteria,3Y6CB@57723|Acidobacteria,2JMEK@204432|Acidobacteriia	204432|Acidobacteriia	S	Endonuclease Exonuclease Phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5224309_6	1254432.SCE1572_40075	2.157e-106	354.0	COG2996@1|root,COG2996@2|Bacteria,1MXC3@1224|Proteobacteria,42P2A@68525|delta/epsilon subdivisions,2WKAS@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	S1 domain	-	-	-	ko:K00243	-	-	-	-	ko00000	-	-	-	S1_2
HKD2_k127_5224309_24	1297742.A176_02228	0.0003077	52.0	2DHGV@1|root,2ZZQ6@2|Bacteria,1PP99@1224|Proteobacteria,433YK@68525|delta/epsilon subdivisions,2X438@28221|Deltaproteobacteria,2YY56@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5224309_9	378806.STAUR_6882	5.239e-83	295.0	COG3509@1|root,COG3509@2|Bacteria,1N6M6@1224|Proteobacteria,42U8Z@68525|delta/epsilon subdivisions,2WQQT@28221|Deltaproteobacteria,2YV47@29|Myxococcales	28221|Deltaproteobacteria	Q	Esterase PHB depolymerase	-	-	-	ko:K03932	-	-	-	-	ko00000	-	CE1	-	Esterase,Esterase_phd,Peptidase_S9,RicinB_lectin_2
HKD2_k127_5224309_20	1279038.KB907345_gene3409	2.382e-10	69.0	COG1309@1|root,COG1309@2|Bacteria,1RGQQ@1224|Proteobacteria,2UF97@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
HKD2_k127_5224309_7	1254432.SCE1572_07895	3.206e-97	336.0	COG2244@1|root,COG2244@2|Bacteria,1QT9H@1224|Proteobacteria,439PF@68525|delta/epsilon subdivisions,2X50Z@28221|Deltaproteobacteria,2YZYN@29|Myxococcales	28221|Deltaproteobacteria	S	polysaccharide biosynthetic process	-	-	-	ko:K06409	-	-	-	-	ko00000,ko02000	2.A.66.2.14	-	-	Polysacc_synt
HKD2_k127_5224309_4	1254432.SCE1572_26290	9.738e-112	386.0	COG0668@1|root,COG0668@2|Bacteria	2|Bacteria	M	transmembrane transport	-	-	-	ko:K03442,ko:K22044	-	-	-	-	ko00000,ko02000	1.A.23.2,1.A.23.3	-	-	LysM,MS_channel,Mu-transpos_C,rve
HKD2_k127_5224309_11	448385.sce4349	3.397e-77	276.0	COG0475@1|root,COG0475@2|Bacteria,1R0CR@1224|Proteobacteria,43CV9@68525|delta/epsilon subdivisions,2X836@28221|Deltaproteobacteria,2Z3JX@29|Myxococcales	28221|Deltaproteobacteria	P	Sodium/hydrogen exchanger family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
HKD2_k127_5224309_3	1254432.SCE1572_26280	2.262e-132	454.0	COG0475@1|root,COG0475@2|Bacteria,1R9PF@1224|Proteobacteria,42RF1@68525|delta/epsilon subdivisions,2WMJJ@28221|Deltaproteobacteria,2Z31T@29|Myxococcales	28221|Deltaproteobacteria	P	Sodium/hydrogen exchanger family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger,PTS_EIIA_2,TrkA_C,TrkA_N
HKD2_k127_5224309_13	469383.Cwoe_1284	5.636e-40	155.0	COG0454@1|root,COG0456@2|Bacteria,2I9Y3@201174|Actinobacteria	201174|Actinobacteria	K	histone acetyltransferase HPA2 and related acetyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10,Acetyltransf_7
HKD2_k127_5224309_5	1254432.SCE1572_21440	1.017e-110	363.0	COG0024@1|root,COG0024@2|Bacteria,1MU99@1224|Proteobacteria,42MM5@68525|delta/epsilon subdivisions,2WJMN@28221|Deltaproteobacteria,2YU2H@29|Myxococcales	28221|Deltaproteobacteria	J	Methionine aminopeptidase	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24,SEC-C
HKD2_k127_5224309_15	215803.DB30_6397	1.245e-27	123.0	COG0583@1|root,COG0583@2|Bacteria,1Q2GW@1224|Proteobacteria,4383E@68525|delta/epsilon subdivisions,2X3DE@28221|Deltaproteobacteria,2YVIG@29|Myxococcales	28221|Deltaproteobacteria	K	Bacterial regulatory helix-turn-helix protein, lysR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1
HKD2_k127_5224309_16	448385.sce2915	6.299e-26	121.0	COG1729@1|root,COG1729@2|Bacteria,1MX82@1224|Proteobacteria,42TQ9@68525|delta/epsilon subdivisions,2WR3B@28221|Deltaproteobacteria,2YUXH@29|Myxococcales	28221|Deltaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_6
HKD2_k127_5224309_12	1370121.AUWS01000082_gene801	1.408e-40	168.0	COG3511@1|root,COG3511@2|Bacteria,2GKPN@201174|Actinobacteria,2368C@1762|Mycobacteriaceae	201174|Actinobacteria	M	virulence factor implicated in the pathogenesis of mycobacterium tuberculosis at the level of intracellular survival, by the alteration of cell signaling events or by direct cytotoxicity catalytic activity a phosphatidylcholine H(2)O 1,2- diacylglycerol choline phosphate	plcB	GO:0003674,GO:0003824,GO:0004620,GO:0004629,GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006629,GO:0008081,GO:0008150,GO:0008152,GO:0009056,GO:0009405,GO:0016020,GO:0016042,GO:0016298,GO:0016787,GO:0016788,GO:0034480,GO:0035821,GO:0042578,GO:0044003,GO:0044238,GO:0044403,GO:0044419,GO:0044464,GO:0051701,GO:0051704,GO:0051817,GO:0052008,GO:0052043,GO:0052111,GO:0052185,GO:0052188,GO:0052368,GO:0071704,GO:0071944,GO:1901575	3.1.4.3	ko:K01114	ko00562,ko00564,ko00565,ko01100,ko01110,ko02024,ko04919,map00562,map00564,map00565,map01100,map01110,map02024,map04919	-	R01312,R02027,R02052,R03332,R07381	RC00017,RC00425	ko00000,ko00001,ko01000,ko02042	-	-	iNJ661.Rv1755c	Phosphoesterase
HKD2_k127_5224309_1	448385.sce2624	8.552e-145	471.0	COG0468@1|root,COG0468@2|Bacteria,1MU3C@1224|Proteobacteria,42M69@68525|delta/epsilon subdivisions,2WIYC@28221|Deltaproteobacteria,2YWK7@29|Myxococcales	28221|Deltaproteobacteria	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage	recA	-	-	ko:K03553	ko03440,map03440	M00729	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	RecA
HKD2_k127_5224309_0	671143.DAMO_3080	1.602e-149	489.0	COG0606@1|root,COG0606@2|Bacteria,2NNW7@2323|unclassified Bacteria	2|Bacteria	O	Magnesium chelatase, subunit ChlI C-terminal	comM	-	-	ko:K07391	-	-	-	-	ko00000	-	-	-	ChlI,Mg_chelatase,Mg_chelatase_C
HKD2_k127_5224309_14	1254432.SCE1572_03230	2.698e-29	127.0	2A4VA@1|root,30TGW@2|Bacteria,1PDBH@1224|Proteobacteria,43E5Q@68525|delta/epsilon subdivisions,2WZT3@28221|Deltaproteobacteria,2Z2PK@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M10
HKD2_k127_5224309_23	1445613.JALM01000044_gene1664	9.038e-06	57.0	COG3315@1|root,COG3315@2|Bacteria,2GM4W@201174|Actinobacteria,4E4XE@85010|Pseudonocardiales	201174|Actinobacteria	Q	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity	-	-	-	ko:K16038	ko01051,ko01052,ko01130,map01051,map01052,map01130	-	R09856	RC00003,RC02842	ko00000,ko00001,ko01000	-	-	-	LCM
HKD2_k127_5224309_19	1120949.KB903328_gene9095	4.234e-15	85.0	COG3315@1|root,COG3315@2|Bacteria,2GN89@201174|Actinobacteria,4DMAK@85008|Micromonosporales	201174|Actinobacteria	Q	Leucine carboxyl methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	LCM
HKD2_k127_5224309_8	1123504.JQKD01000025_gene5857	2.399e-86	323.0	COG3831@1|root,COG3831@2|Bacteria,1QWC3@1224|Proteobacteria,2W8UM@28216|Betaproteobacteria,4AGCG@80864|Comamonadaceae	28216|Betaproteobacteria	S	Proposed nucleic acid binding domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4132,WGR
HKD2_k127_5224309_22	350054.Mflv_1048	3.97e-06	49.0	29ZB7@1|root,30M9P@2|Bacteria,2IJNK@201174|Actinobacteria,239Q1@1762|Mycobacteriaceae	201174|Actinobacteria	S	Domain of unknown function (DUF4333)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4333
HKD2_k127_5228217_0	1192034.CAP_2194	5.706e-173	546.0	COG0542@1|root,COG0542@2|Bacteria,1MURH@1224|Proteobacteria,42M9S@68525|delta/epsilon subdivisions,2WJSZ@28221|Deltaproteobacteria,2YUBF@29|Myxococcales	28221|Deltaproteobacteria	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpB	-	-	ko:K03695	ko04213,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
HKD2_k127_5228217_2	1254432.SCE1572_07160	5.56e-22	100.0	COG2827@1|root,COG2827@2|Bacteria,1N6PA@1224|Proteobacteria,42VGM@68525|delta/epsilon subdivisions,2WRJ4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	PFAM Excinuclease ABC C subunit domain protein	-	-	-	ko:K07461	-	-	-	-	ko00000	-	-	-	GIY-YIG
HKD2_k127_5228217_1	1056816.JAFQ01000004_gene7121	5.001e-85	300.0	COG2267@1|root,COG2267@2|Bacteria,2GJ78@201174|Actinobacteria,4G081@85025|Nocardiaceae	201174|Actinobacteria	I	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
HKD2_k127_5228217_3	944564.HMPREF9200_1656	1.017e-15	84.0	COG1538@1|root,COG1538@2|Bacteria,1TRDS@1239|Firmicutes,4H2S7@909932|Negativicutes	909932|Negativicutes	MU	outer membrane efflux protein	tolC	-	-	-	-	-	-	-	-	-	-	-	OEP
HKD2_k127_522824_1	1042375.AFPL01000006_gene2937	9.719e-29	131.0	COG2304@1|root,COG2304@2|Bacteria,1MUTS@1224|Proteobacteria,1RQPC@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	von willebrand factor, type A	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VWA
HKD2_k127_5230733_2	1345695.CLSA_c16250	1.072e-07	62.0	COG1388@1|root,COG1388@2|Bacteria,1V4FC@1239|Firmicutes,24CPD@186801|Clostridia,36GV9@31979|Clostridiaceae	186801|Clostridia	M	LysM domain	-	-	-	-	-	-	-	-	-	-	-	-	LysM
HKD2_k127_5230733_0	1192034.CAP_4002	1.219e-147	512.0	COG1207@1|root,COG1207@2|Bacteria,1MUPH@1224|Proteobacteria,42N3K@68525|delta/epsilon subdivisions,2WIMV@28221|Deltaproteobacteria,2YTY5@29|Myxococcales	28221|Deltaproteobacteria	M	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain	glmU	-	2.3.1.157,2.7.7.23	ko:K04042,ko:K11528	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transf_3,NTP_transferase
HKD2_k127_5230733_1	1254432.SCE1572_32425	2.215e-89	331.0	2AIZE@1|root,319HE@2|Bacteria,1Q2SG@1224|Proteobacteria,438E3@68525|delta/epsilon subdivisions,2X3P8@28221|Deltaproteobacteria,2YWR0@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5243564_0	215803.DB30_5628	3.117e-110	365.0	COG1953@1|root,COG1953@2|Bacteria,1MV18@1224|Proteobacteria,42X2Z@68525|delta/epsilon subdivisions,2WTRX@28221|Deltaproteobacteria,2YTSH@29|Myxococcales	28221|Deltaproteobacteria	FH	Permease for cytosine/purines, uracil, thiamine, allantoin	-	-	-	ko:K03457	-	-	-	-	ko00000	2.A.39	-	-	Transp_cyt_pur
HKD2_k127_5243564_1	1254432.SCE1572_37900	2.553e-108	372.0	COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,42MGY@68525|delta/epsilon subdivisions,2WJHC@28221|Deltaproteobacteria,2YUCU@29|Myxococcales	28221|Deltaproteobacteria	E	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	-	-	1.3.1.1	ko:K17722	ko00240,ko00410,ko00770,ko01100,map00240,map00410,map00770,map01100	M00046	R00977,R01414,R11026	RC00072,RC00123	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4_20,Pyr_redox_2
HKD2_k127_5243564_2	378806.STAUR_8046	1.268e-101	342.0	COG0167@1|root,COG1146@1|root,COG0167@2|Bacteria,COG1146@2|Bacteria,1MXER@1224|Proteobacteria,42YD3@68525|delta/epsilon subdivisions,2WTVV@28221|Deltaproteobacteria,2YU0M@29|Myxococcales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	yeiA	-	1.3.1.1	ko:K17723	ko00240,ko00410,ko00770,ko01100,map00240,map00410,map00770,map01100	M00046	R00977,R01414,R11026	RC00072,RC00123	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh,Fer4_21
HKD2_k127_5245595_0	1192034.CAP_8242	2.995e-95	347.0	COG1506@1|root,COG1506@2|Bacteria	2|Bacteria	E	serine-type peptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	AXE1,Peptidase_S9
HKD2_k127_5245595_1	448385.sce3938	1.818e-35	140.0	2E6J8@1|root,3316B@2|Bacteria,1N7GY@1224|Proteobacteria,42V6W@68525|delta/epsilon subdivisions,2WRHG@28221|Deltaproteobacteria,2YYZA@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5245595_2	448385.sce3937	2.173e-11	66.0	2CIY5@1|root,2ZET1@2|Bacteria,1P8MM@1224|Proteobacteria,4330I@68525|delta/epsilon subdivisions,2WXKY@28221|Deltaproteobacteria,2YW19@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5248519_5	448385.sce5119	8.014e-16	90.0	COG0584@1|root,COG0584@2|Bacteria,1MU8H@1224|Proteobacteria,42U7W@68525|delta/epsilon subdivisions,2WQ9A@28221|Deltaproteobacteria,2YVEF@29|Myxococcales	28221|Deltaproteobacteria	C	glycerophosphoryl diester phosphodiesterase	glpQ	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD
HKD2_k127_5248519_1	1254432.SCE1572_31055	9.428e-96	323.0	COG2404@1|root,COG2404@2|Bacteria,1QW0R@1224|Proteobacteria,43BQN@68525|delta/epsilon subdivisions,2X71Q@28221|Deltaproteobacteria,2YUZT@29|Myxococcales	28221|Deltaproteobacteria	S	COG0618 Exopolyphosphatase-related proteins	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5248519_0	448385.sce6492	7.234e-101	347.0	COG0515@1|root,COG0515@2|Bacteria,1Q35Q@1224|Proteobacteria,438W9@68525|delta/epsilon subdivisions,2X41T@28221|Deltaproteobacteria,2YXZI@29|Myxococcales	28221|Deltaproteobacteria	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K08884	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HKD2_k127_5248519_6	378806.STAUR_1844	1.343e-10	71.0	COG2374@1|root,COG5492@1|root,COG2374@2|Bacteria,COG5492@2|Bacteria,1PZBJ@1224|Proteobacteria,42UE8@68525|delta/epsilon subdivisions,2WVIZ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	N	Bacterial Ig-like domain 2	-	-	-	-	-	-	-	-	-	-	-	-	Big_2
HKD2_k127_5248519_3	388413.ALPR1_17418	8.572e-27	126.0	COG0508@1|root,COG0508@2|Bacteria,4NJ7Y@976|Bacteroidetes,47P7H@768503|Cytophagia	976|Bacteroidetes	C	dehydrogenase complex catalyzes the overall conversion of	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5248519_4	1297742.A176_07189	6.834e-18	95.0	COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,42MFC@68525|delta/epsilon subdivisions,2WJ4H@28221|Deltaproteobacteria,2YU21@29|Myxococcales	28221|Deltaproteobacteria	H	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor	bioA	-	2.6.1.62	ko:K00833	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03231	RC00006,RC00887	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	AAA_26,Aminotran_3
HKD2_k127_5249922_6	1026882.MAMP_02074	1.568e-08	66.0	28HU5@1|root,2Z80X@2|Bacteria,1R55N@1224|Proteobacteria,1RMAG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	TIGRFAM TIGR03790 family protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5249922_3	1192034.CAP_7081	1.66e-71	274.0	COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,42P55@68525|delta/epsilon subdivisions,2WJNC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	EH	PFAM chorismate	pabB	-	2.6.1.85	ko:K01665	ko00790,map00790	-	R01716	RC00010,RC01418	ko00000,ko00001,ko01000	-	-	-	Aminotran_4,Anth_synt_I_N,Chorismate_bind
HKD2_k127_5249922_0	1192034.CAP_6865	3.389e-196	629.0	COG0018@1|root,COG0018@2|Bacteria,1MU4J@1224|Proteobacteria,42MTY@68525|delta/epsilon subdivisions,2WKII@28221|Deltaproteobacteria,2YWMT@29|Myxococcales	28221|Deltaproteobacteria	J	Arginyl tRNA synthetase N terminal dom	argS	GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	iAF987.Gmet_1434	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
HKD2_k127_5249922_4	1254432.SCE1572_22055	7.684e-47	178.0	COG3147@1|root,COG3147@2|Bacteria,1NGE3@1224|Proteobacteria,43C1W@68525|delta/epsilon subdivisions,2X7CG@28221|Deltaproteobacteria,2YVUH@29|Myxococcales	28221|Deltaproteobacteria	S	Sporulation related domain	-	-	-	-	-	-	-	-	-	-	-	-	SPOR
HKD2_k127_5249922_2	448385.sce5916	1.015e-84	290.0	COG0121@1|root,COG0121@2|Bacteria,1PXTX@1224|Proteobacteria,434UP@68525|delta/epsilon subdivisions,2WZ5R@28221|Deltaproteobacteria,2Z1DW@29|Myxococcales	28221|Deltaproteobacteria	S	Glutamine amidotransferases class-II	-	-	-	-	-	-	-	-	-	-	-	-	GATase_4
HKD2_k127_5249922_7	1254432.SCE1572_35250	8.392e-08	61.0	COG5567@1|root,COG5567@2|Bacteria	2|Bacteria	N	small periplasmic lipoprotein	yifL	-	-	-	-	-	-	-	-	-	-	-	LPAM_2
HKD2_k127_5249922_1	1192034.CAP_5604	1.339e-89	315.0	COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,439RU@68525|delta/epsilon subdivisions,2X54N@28221|Deltaproteobacteria,2Z03Z@29|Myxococcales	28221|Deltaproteobacteria	K	Forkhead associated domain	-	-	-	-	-	-	-	-	-	-	-	-	FHA,Sigma54_activat
HKD2_k127_5249922_8	3067.XP_002946028.1	9.822e-05	47.0	COG0237@1|root,KOG3220@2759|Eukaryota,37RNA@33090|Viridiplantae,34KGE@3041|Chlorophyta	3041|Chlorophyta	H	Dephospho-CoA kinase	-	-	2.7.1.24	ko:K00859	ko00770,ko01100,map00770,map01100	M00120	R00130	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	iRC1080.CRv4_Au5_s10_g369_t1	CoaE
HKD2_k127_5255559_0	1267535.KB906767_gene5488	2.446e-247	777.0	COG0067@1|root,COG0069@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,3Y2JQ@57723|Acidobacteria,2JHR5@204432|Acidobacteriia	204432|Acidobacteriia	E	GXGXG motif	-	-	1.4.1.13,1.4.1.14	ko:K00265	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
HKD2_k127_5258537_3	1254432.SCE1572_10315	7.432e-41	160.0	COG4137@1|root,COG4137@2|Bacteria,1R3M0@1224|Proteobacteria,43DKU@68525|delta/epsilon subdivisions,2X8S0@28221|Deltaproteobacteria,2YW4U@29|Myxococcales	28221|Deltaproteobacteria	S	Cytochrome C assembly protein	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C_asm
HKD2_k127_5258537_4	1192034.CAP_7200	7.011e-40	151.0	2A21P@1|root,30QBQ@2|Bacteria,1Q2MF@1224|Proteobacteria,43882@68525|delta/epsilon subdivisions,2X3HT@28221|Deltaproteobacteria,2YW5S@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5258537_1	448385.sce5135	2.086e-70	252.0	COG1018@1|root,COG1018@2|Bacteria,1MW37@1224|Proteobacteria,432D0@68525|delta/epsilon subdivisions,2WY0P@28221|Deltaproteobacteria,2Z211@29|Myxococcales	28221|Deltaproteobacteria	C	Oxidoreductase NAD-binding domain	-	-	1.18.1.2,1.19.1.1	ko:K00528	-	-	R10159	-	ko00000,ko01000	-	-	-	FAD_binding_6,NAD_binding_1
HKD2_k127_5258537_2	215803.DB30_1221	4.18e-50	201.0	COG1028@1|root,COG1028@2|Bacteria,1RJVE@1224|Proteobacteria	1224|Proteobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HKD2_k127_5258537_0	1192034.CAP_5842	1.995e-93	321.0	COG1652@1|root,COG1652@2|Bacteria,1MUBV@1224|Proteobacteria,42QS9@68525|delta/epsilon subdivisions,2WN3H@28221|Deltaproteobacteria,2YVFR@29|Myxococcales	28221|Deltaproteobacteria	S	LysM domain	-	-	-	-	-	-	-	-	-	-	-	-	LysM
HKD2_k127_5276343_0	502025.Hoch_2064	2.806e-116	390.0	COG3173@1|root,COG3173@2|Bacteria,1MWAK@1224|Proteobacteria,42PQ6@68525|delta/epsilon subdivisions,2WJHR@28221|Deltaproteobacteria,2YV9V@29|Myxococcales	28221|Deltaproteobacteria	S	Aminoglycoside phosphotransferase	-	-	-	-	-	-	-	-	-	-	-	-	APH
HKD2_k127_5276343_2	1382306.JNIM01000001_gene3726	2.808e-36	154.0	COG1502@1|root,COG1502@2|Bacteria,2G9TQ@200795|Chloroflexi	200795|Chloroflexi	I	Archaeal transcriptional regulator TrmB	-	-	-	-	-	-	-	-	-	-	-	-	PLDc_2
HKD2_k127_5276343_4	67275.JOAP01000006_gene6229	7.202e-05	54.0	COG1846@1|root,COG1846@2|Bacteria,2IQNM@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
HKD2_k127_5276343_1	1379270.AUXF01000001_gene2028	3.413e-53	189.0	COG0623@1|root,COG0623@2|Bacteria,1ZTGW@142182|Gemmatimonadetes	142182|Gemmatimonadetes	I	Enoyl-(Acyl carrier protein) reductase	-	-	1.3.1.10,1.3.1.9	ko:K00208	ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212	M00083,M00572	R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671	RC00052,RC00076,RC00120	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HKD2_k127_5277140_2	1242864.D187_006073	1.258e-55	195.0	COG0312@1|root,COG0312@2|Bacteria,1MUSK@1224|Proteobacteria,42Y66@68525|delta/epsilon subdivisions,2WU83@28221|Deltaproteobacteria,2YX71@29|Myxococcales	28221|Deltaproteobacteria	S	Putative modulator of DNA gyrase	-	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
HKD2_k127_5277140_0	404589.Anae109_3957	7.987e-160	520.0	COG0312@1|root,COG0312@2|Bacteria,1RBJZ@1224|Proteobacteria,42YBE@68525|delta/epsilon subdivisions,2WUP7@28221|Deltaproteobacteria,2YZ4Y@29|Myxococcales	28221|Deltaproteobacteria	L	Putative modulator of DNA gyrase	-	-	-	ko:K03592	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
HKD2_k127_5277140_1	1144275.COCOR_00071	2.487e-130	431.0	COG1690@1|root,COG1690@2|Bacteria,1MUHA@1224|Proteobacteria,42MZN@68525|delta/epsilon subdivisions,2WJGK@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Belongs to the RtcB family	-	-	6.5.1.3	ko:K14415	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RtcB
HKD2_k127_5277140_3	1254432.SCE1572_33650	2.718e-54	196.0	COG1403@1|root,COG1403@2|Bacteria,1MWEQ@1224|Proteobacteria,42U6P@68525|delta/epsilon subdivisions,2WQ00@28221|Deltaproteobacteria,2YVG1@29|Myxococcales	28221|Deltaproteobacteria	L	HNH endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	HNH_5
HKD2_k127_5277140_4	1192034.CAP_5912	9.145e-15	76.0	COG3291@1|root,COG3291@2|Bacteria,1QEIS@1224|Proteobacteria,4389M@68525|delta/epsilon subdivisions,2X3J1@28221|Deltaproteobacteria,2YWAB@29|Myxococcales	28221|Deltaproteobacteria	S	IgGFc binding protein	-	-	-	-	-	-	-	-	-	-	-	-	IgGFc_binding
HKD2_k127_5282291_4	502025.Hoch_2129	1.499e-19	96.0	COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,42MKR@68525|delta/epsilon subdivisions,2X1W0@28221|Deltaproteobacteria,2YUZR@29|Myxococcales	28221|Deltaproteobacteria	E	Aminotransferase class I and II	-	-	2.6.1.17	ko:K14267	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R04475	RC00006	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
HKD2_k127_5282291_2	861299.J421_2315	6.331e-50	200.0	COG1079@1|root,COG1079@2|Bacteria,1ZTFZ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	U	Branched-chain amino acid transport system / permease component	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
HKD2_k127_5282291_1	1254432.SCE1572_34805	6.874e-79	293.0	COG4603@1|root,COG4603@2|Bacteria,1MX6V@1224|Proteobacteria,42RQG@68525|delta/epsilon subdivisions,2WNDT@28221|Deltaproteobacteria,2YZU8@29|Myxococcales	28221|Deltaproteobacteria	U	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
HKD2_k127_5282291_0	1254432.SCE1572_34810	1.053e-108	371.0	COG3845@1|root,COG3845@2|Bacteria,1NT0H@1224|Proteobacteria,42NTY@68525|delta/epsilon subdivisions,2WK4F@28221|Deltaproteobacteria,2YUKQ@29|Myxococcales	28221|Deltaproteobacteria	S	ABC transporter	-	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
HKD2_k127_5282291_3	502025.Hoch_4145	5.385e-29	120.0	COG1629@1|root,COG4771@2|Bacteria,1R5B9@1224|Proteobacteria,43C1I@68525|delta/epsilon subdivisions,2X7C6@28221|Deltaproteobacteria,2YWPC@29|Myxococcales	28221|Deltaproteobacteria	MP	Periplasmic protein TonB links inner and outer membranes	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5282444_3	1408310.JHUW01000008_gene2286	1.294e-08	60.0	COG2127@1|root,COG2127@2|Bacteria,4NZB5@976|Bacteroidetes,2FT55@200643|Bacteroidia	976|Bacteroidetes	S	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation	clpS	-	-	ko:K06891	-	-	-	-	ko00000	-	-	-	ClpS
HKD2_k127_5282444_1	1192034.CAP_8052	1.216e-101	355.0	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,42NF6@68525|delta/epsilon subdivisions,2WKVH@28221|Deltaproteobacteria,2YY53@29|Myxococcales	28221|Deltaproteobacteria	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD2_k127_5282444_2	1192034.CAP_8051	6.178e-24	112.0	COG1277@1|root,COG1277@2|Bacteria,1Q2JV@1224|Proteobacteria,4386Q@68525|delta/epsilon subdivisions,2X3GK@28221|Deltaproteobacteria,2YW06@29|Myxococcales	28221|Deltaproteobacteria	S	ABC-2 family transporter protein	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane_2
HKD2_k127_5282444_0	1192034.CAP_2885	5.472e-131	437.0	COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,42M5E@68525|delta/epsilon subdivisions,2WIV6@28221|Deltaproteobacteria,2YTXT@29|Myxococcales	28221|Deltaproteobacteria	J	Ribonuclease E/G family	cafA	-	-	ko:K08301	-	-	-	-	ko00000,ko01000,ko03009,ko03019	-	-	-	RNase_E_G,S1
HKD2_k127_5285088_0	1122609.AUGT01000022_gene730	2.08e-165	538.0	COG0243@1|root,COG0243@2|Bacteria,2GNYQ@201174|Actinobacteria,4DN5N@85009|Propionibacteriales	201174|Actinobacteria	C	Molybdopterin oxidoreductase Fe4S4 domain	-	-	-	-	-	-	-	-	-	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
HKD2_k127_5285088_2	448385.sce7905	6.114e-109	360.0	COG1250@1|root,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,42PBC@68525|delta/epsilon subdivisions,2WM7S@28221|Deltaproteobacteria,2YY2B@29|Myxococcales	28221|Deltaproteobacteria	C	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain	-	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
HKD2_k127_5285088_7	1192034.CAP_8496	1.486e-84	299.0	COG0515@1|root,COG0515@2|Bacteria	1192034.CAP_8496|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5285088_1	1192034.CAP_8401	3.217e-158	509.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,42MSR@68525|delta/epsilon subdivisions,2WIXG@28221|Deltaproteobacteria,2YUBG@29|Myxococcales	28221|Deltaproteobacteria	I	Belongs to the thiolase family	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
HKD2_k127_5285088_6	448385.sce1712	9.208e-91	307.0	COG0847@1|root,COG0847@2|Bacteria,1PER2@1224|Proteobacteria,42WAS@68525|delta/epsilon subdivisions,2WWG3@28221|Deltaproteobacteria,2Z1FU@29|Myxococcales	28221|Deltaproteobacteria	L	PFAM Exonuclease RNase T and DNA polymerase III	-	-	2.7.7.7	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	RNase_T
HKD2_k127_5285088_8	448385.sce1714	1.291e-60	231.0	COG0669@1|root,COG0669@2|Bacteria,1RD9F@1224|Proteobacteria,42RJQ@68525|delta/epsilon subdivisions,2WNDS@28221|Deltaproteobacteria,2YYUB@29|Myxococcales	28221|Deltaproteobacteria	H	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate	coaD	GO:0003674,GO:0003824,GO:0004595,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.7.3	ko:K00954	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
HKD2_k127_5285088_4	448385.sce5862	6.585e-98	335.0	COG0005@1|root,COG0005@2|Bacteria,1MUWW@1224|Proteobacteria,42P3C@68525|delta/epsilon subdivisions,2WJW1@28221|Deltaproteobacteria,2YUUB@29|Myxococcales	28221|Deltaproteobacteria	F	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate	punA	-	2.4.2.1	ko:K03783	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R01561,R01863,R01969,R02147,R02294,R02295,R02297,R02484,R02557,R02748,R08368,R10244	RC00033,RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	PNP_UDP_1
HKD2_k127_5285088_9	448385.sce5863	1.302e-29	130.0	COG0295@1|root,COG0295@2|Bacteria,1MY2R@1224|Proteobacteria,42UZH@68525|delta/epsilon subdivisions,2WR2R@28221|Deltaproteobacteria,2YVFS@29|Myxococcales	28221|Deltaproteobacteria	F	This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis	cdd	-	3.5.4.5	ko:K01489	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01878,R02485,R08221	RC00074,RC00514	ko00000,ko00001,ko01000	-	-	-	dCMP_cyt_deam_1
HKD2_k127_5285088_5	502025.Hoch_3711	2.867e-92	329.0	COG0823@1|root,COG0823@2|Bacteria,1PFBB@1224|Proteobacteria,432XJ@68525|delta/epsilon subdivisions,2WXKI@28221|Deltaproteobacteria	28221|Deltaproteobacteria	U	Involved in the tonB-independent uptake of proteins	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5289344_6	448385.sce4033	4.243e-22	101.0	2AJ10@1|root,319J4@2|Bacteria,1Q2X4@1224|Proteobacteria,438K5@68525|delta/epsilon subdivisions,2X3UQ@28221|Deltaproteobacteria,2YX5Z@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5289344_1	331869.BAL199_12246	1.895e-47	179.0	COG0625@1|root,COG0625@2|Bacteria,1RHSK@1224|Proteobacteria,2U5GF@28211|Alphaproteobacteria,4BQSF@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	O	Glutathione S-transferase, N-terminal domain	yibF	-	-	-	-	-	-	-	-	-	-	-	GST_C_2,GST_N_3
HKD2_k127_5289344_8	1254432.SCE1572_25630	1.412e-12	74.0	2EGD2@1|root,33A4V@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF2752)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2752
HKD2_k127_5289344_9	397290.C810_02027	2.73e-07	58.0	2EGCD@1|root,33A46@2|Bacteria,1VMG3@1239|Firmicutes,24UKI@186801|Clostridia,27QFA@186928|unclassified Lachnospiraceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4190
HKD2_k127_5289344_11	1416759.AYMR01000024_gene2597	4.229e-05	53.0	COG1846@1|root,COG1846@2|Bacteria,2HPHY@201174|Actinobacteria,4FS87@85023|Microbacteriaceae	201174|Actinobacteria	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	MarR
HKD2_k127_5289344_0	1192034.CAP_4131	5.092e-213	680.0	COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,42PZH@68525|delta/epsilon subdivisions,2WJ0T@28221|Deltaproteobacteria,2YTTX@29|Myxococcales	28221|Deltaproteobacteria	C	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M
HKD2_k127_5289344_5	1254432.SCE1572_35205	9.857e-28	126.0	2AI7D@1|root,318MR@2|Bacteria,1Q0MU@1224|Proteobacteria,436RD@68525|delta/epsilon subdivisions,2X1E8@28221|Deltaproteobacteria,2YW7E@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5289344_3	448385.sce5909	8.907e-38	148.0	2E05E@1|root,32VTR@2|Bacteria,1N5CW@1224|Proteobacteria,431HU@68525|delta/epsilon subdivisions,2WWRZ@28221|Deltaproteobacteria,2YVXX@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5289344_2	404589.Anae109_3714	7.707e-46	168.0	COG0234@1|root,COG0234@2|Bacteria,1MZ2X@1224|Proteobacteria,42U7E@68525|delta/epsilon subdivisions,2WPZP@28221|Deltaproteobacteria,2YVK0@29|Myxococcales	28221|Deltaproteobacteria	O	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter	groS	GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008150,GO:0009987,GO:0010033,GO:0035966,GO:0042221,GO:0043167,GO:0043169,GO:0046872,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0061077	-	ko:K04078	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Cpn10
HKD2_k127_5289344_7	448385.sce5911	2.748e-15	76.0	COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,42M52@68525|delta/epsilon subdivisions,2WIRK@28221|Deltaproteobacteria,2YUQN@29|Myxococcales	28221|Deltaproteobacteria	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0016465,GO:0032991,GO:0044183,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051082,GO:0061077,GO:0101031,GO:1990220	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
HKD2_k127_5295991_0	1242864.D187_006956	1.41e-40	169.0	2BT4P@1|root,32N9B@2|Bacteria,1Q3NK@1224|Proteobacteria,43423@68525|delta/epsilon subdivisions,2X4RH@28221|Deltaproteobacteria,2YZFZ@29|Myxococcales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF445)	-	-	-	-	-	-	-	-	-	-	-	-	DUF445
HKD2_k127_5300232_1	1123073.KB899245_gene60	2.232e-24	102.0	COG0156@1|root,COG0156@2|Bacteria,1MVVH@1224|Proteobacteria,1RNS6@1236|Gammaproteobacteria,1X3NP@135614|Xanthomonadales	135614|Xanthomonadales	H	Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA	kbl	-	2.3.1.29	ko:K00639	ko00260,map00260	-	R00371	RC00004,RC00394	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
HKD2_k127_5300232_0	1216007.AOPM01000042_gene2815	6.041e-35	143.0	COG3571@1|root,COG3571@2|Bacteria,1RD20@1224|Proteobacteria,1S3Y4@1236|Gammaproteobacteria,2Q27M@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	S	hydrolase of the alpha beta-hydrolase fold	-	-	-	ko:K07020	-	-	-	-	ko00000	-	-	-	Abhydrolase_6,DLH
HKD2_k127_5301753_0	1192034.CAP_2853	2.049e-62	221.0	COG2255@1|root,COG2255@2|Bacteria,1MU38@1224|Proteobacteria,42M99@68525|delta/epsilon subdivisions,2WJ2Q@28221|Deltaproteobacteria,2YUGW@29|Myxococcales	28221|Deltaproteobacteria	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing	ruvB	-	3.6.4.12	ko:K03551	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvB_C,RuvB_N
HKD2_k127_5301753_1	483219.LILAB_36240	5.67e-57	211.0	COG3000@1|root,COG3000@2|Bacteria,1NBCT@1224|Proteobacteria	1224|Proteobacteria	I	B domain of TMEM189, localisation domain	carF	-	-	ko:K20656	-	-	-	-	ko00000,ko04131	-	-	-	TMEM189_B_dmain
HKD2_k127_5301753_3	1003195.SCAT_1777	4.184e-31	138.0	COG0631@1|root,COG0631@2|Bacteria,2GKDM@201174|Actinobacteria	201174|Actinobacteria	T	SMART protein phosphatase 2C domain protein	prpB10	-	-	-	-	-	-	-	-	-	-	-	DZR,PP2C_2
HKD2_k127_5301753_4	1192034.CAP_3958	2.408e-18	98.0	COG2304@1|root,COG2304@2|Bacteria	2|Bacteria	IU	oxidoreductase activity	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VWA,VWA_2
HKD2_k127_5301753_2	448385.sce2576	5.35e-44	171.0	COG0340@1|root,COG0340@2|Bacteria,1MWCC@1224|Proteobacteria,42P6I@68525|delta/epsilon subdivisions,2WMAF@28221|Deltaproteobacteria,2YVIU@29|Myxococcales	28221|Deltaproteobacteria	H	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor	birA	-	6.3.4.15	ko:K03524	ko00780,ko01100,map00780,map01100	-	R01074,R05145	RC00043,RC00070,RC00096,RC02896	ko00000,ko00001,ko01000,ko03000	-	-	-	BPL_C,BPL_LplA_LipB,HTH_11
HKD2_k127_5302222_7	1254432.SCE1572_35405	1.347e-30	141.0	COG3215@1|root,COG3215@2|Bacteria,1QASH@1224|Proteobacteria,4359S@68525|delta/epsilon subdivisions,2X978@28221|Deltaproteobacteria,2Z2CF@29|Myxococcales	28221|Deltaproteobacteria	NU	PilZ domain	-	-	-	-	-	-	-	-	-	-	-	-	PilZ
HKD2_k127_5302222_1	1254432.SCE1572_35410	2.972e-179	608.0	COG1807@1|root,COG1807@2|Bacteria,1P6BI@1224|Proteobacteria,433Q7@68525|delta/epsilon subdivisions,2WXUY@28221|Deltaproteobacteria,2Z13P@29|Myxococcales	28221|Deltaproteobacteria	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HKD2_k127_5302222_4	546271.Selsp_1565	3.911e-70	272.0	COG1159@1|root,COG1159@2|Bacteria,1TP3R@1239|Firmicutes,4H1WW@909932|Negativicutes	909932|Negativicutes	S	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism	era	-	-	ko:K03595	-	-	-	-	ko00000,ko03009,ko03029	-	-	-	KH_2,MMR_HSR1
HKD2_k127_5302222_2	448385.sce5952	1.999e-167	552.0	COG1160@1|root,COG1160@2|Bacteria,1MU9S@1224|Proteobacteria,42M3N@68525|delta/epsilon subdivisions,2WISS@28221|Deltaproteobacteria,2YU6J@29|Myxococcales	28221|Deltaproteobacteria	S	GTPase that plays an essential role in the late steps of ribosome biogenesis	der	-	-	ko:K03977	-	-	-	-	ko00000,ko03009	-	-	-	KH_dom-like,MMR_HSR1
HKD2_k127_5302222_3	448385.sce5953	5.289e-119	393.0	COG0003@1|root,COG0003@2|Bacteria,1PMWP@1224|Proteobacteria,42RUR@68525|delta/epsilon subdivisions,2WNEE@28221|Deltaproteobacteria,2YUU4@29|Myxococcales	28221|Deltaproteobacteria	D	AAA domain	agmR	-	-	-	-	-	-	-	-	-	-	-	ArsA_ATPase
HKD2_k127_5302222_0	1254432.SCE1572_40790	1.141e-209	663.0	COG0305@1|root,COG0305@2|Bacteria,1MUG9@1224|Proteobacteria,42M7X@68525|delta/epsilon subdivisions,2WJCA@28221|Deltaproteobacteria,2YTXF@29|Myxococcales	28221|Deltaproteobacteria	L	it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins	dnaB	-	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C
HKD2_k127_5302222_5	479435.Kfla_3354	4.464e-32	137.0	COG1028@1|root,COG1028@2|Bacteria,2IN8D@201174|Actinobacteria	201174|Actinobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short
HKD2_k127_5302222_8	517418.Ctha_0651	4.119e-09	58.0	COG0359@1|root,COG0359@2|Bacteria,1FE3E@1090|Chlorobi	1090|Chlorobi	J	Binds to the 23S rRNA	rplI	-	-	ko:K02939	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L9_C,Ribosomal_L9_N
HKD2_k127_5302787_1	1254432.SCE1572_44095	2.175e-41	156.0	COG2006@1|root,COG2006@2|Bacteria	2|Bacteria	U	4fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF2088,DUF362
HKD2_k127_5302787_2	1192034.CAP_8313	6.145e-18	95.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5302787_0	448385.sce2902	2.031e-46	172.0	COG1716@1|root,COG2199@1|root,COG1716@2|Bacteria,COG3706@2|Bacteria,1MZV7@1224|Proteobacteria,43BQ2@68525|delta/epsilon subdivisions,2WQ6X@28221|Deltaproteobacteria,2Z2WS@29|Myxococcales	28221|Deltaproteobacteria	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	FHA,GGDEF,Yop-YscD_cpl
HKD2_k127_5320324_1	1192034.CAP_5637	3.51e-92	311.0	COG1721@1|root,COG1721@2|Bacteria,1MWPG@1224|Proteobacteria	1224|Proteobacteria	S	conserved protein (some members contain a von Willebrand factor type A (vWA) domain)	MA20_44650	-	-	-	-	-	-	-	-	-	-	-	DUF58
HKD2_k127_5348072_0	448385.sce1626	7.3e-175	565.0	COG1543@1|root,COG1543@2|Bacteria,1R5SN@1224|Proteobacteria,42PSX@68525|delta/epsilon subdivisions,2WU5G@28221|Deltaproteobacteria,2YTTH@29|Myxococcales	28221|Deltaproteobacteria	G	Belongs to the glycosyl hydrolase 57 family	-	-	2.4.1.18	ko:K16149	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000	-	GH57	-	DUF1957,Glyco_hydro_57
HKD2_k127_5348072_1	1254432.SCE1572_46105	7.12e-85	291.0	COG0329@1|root,COG0329@2|Bacteria,1MUCM@1224|Proteobacteria,42M0X@68525|delta/epsilon subdivisions,2WK4D@28221|Deltaproteobacteria,2YUVE@29|Myxococcales	28221|Deltaproteobacteria	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	dapA	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
HKD2_k127_5348072_2	448385.sce8028	2.498e-61	224.0	COG0289@1|root,COG0289@2|Bacteria,1MUCT@1224|Proteobacteria,42N84@68525|delta/epsilon subdivisions,2WJKT@28221|Deltaproteobacteria,2YZXG@29|Myxococcales	28221|Deltaproteobacteria	E	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate	dapB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008839,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019752,GO:0019877,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576	1.17.1.8	ko:K00215	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R04198,R04199	RC00478	ko00000,ko00001,ko00002,ko01000	-	-	-	DapB_C,DapB_N
HKD2_k127_5348072_3	448385.sce8058	1.968e-17	92.0	29RQC@1|root,30CTT@2|Bacteria,1QTPW@1224|Proteobacteria,435D4@68525|delta/epsilon subdivisions,2WZQP@28221|Deltaproteobacteria,2Z2IY@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	PEGA
HKD2_k127_5350943_4	530564.Psta_0491	5.639e-39	155.0	COG2204@1|root,COG2204@2|Bacteria,2IXMN@203682|Planctomycetes	203682|Planctomycetes	T	COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains	-	-	-	ko:K02481	-	-	-	-	ko00000,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD2_k127_5350943_10	555778.Hneap_1075	9.39e-08	64.0	29FS0@1|root,302PP@2|Bacteria,1RE1Q@1224|Proteobacteria,1S4I9@1236|Gammaproteobacteria,1X0Z0@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5350943_0	1384054.N790_13735	6.528e-118	398.0	COG0633@1|root,COG1018@1|root,COG2346@1|root,COG0633@2|Bacteria,COG1018@2|Bacteria,COG2346@2|Bacteria,1REP4@1224|Proteobacteria,1T2XC@1236|Gammaproteobacteria,1XDHE@135614|Xanthomonadales	135614|Xanthomonadales	C	Bacterial-like globin	-	-	-	-	-	-	-	-	-	-	-	-	Bac_globin,FAD_binding_6,Fer2,NAD_binding_1
HKD2_k127_5350943_5	391625.PPSIR1_11570	1.974e-38	160.0	COG1100@1|root,COG1100@2|Bacteria	2|Bacteria	S	GTP binding	-	-	-	ko:K06883	-	-	-	-	ko00000	-	-	-	DUF697,MMR_HSR1
HKD2_k127_5350943_2	1122197.ATWI01000008_gene3138	2.952e-60	231.0	COG0639@1|root,COG0639@2|Bacteria,1MUV1@1224|Proteobacteria,1RPFZ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Calcineurin-like phosphoesterase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos_2
HKD2_k127_5350943_6	1123256.KB907925_gene1045	1.216e-31	138.0	COG3829@1|root,COG3829@2|Bacteria,1QZHD@1224|Proteobacteria,1S631@1236|Gammaproteobacteria,1X91E@135614|Xanthomonadales	135614|Xanthomonadales	KT	transcription factor binding	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5350943_3	688245.CtCNB1_3970	4.562e-49	178.0	COG3829@1|root,COG3829@2|Bacteria,1REUB@1224|Proteobacteria,2VRFH@28216|Betaproteobacteria,4AE2K@80864|Comamonadaceae	28216|Betaproteobacteria	KT	transcription factor binding	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5350943_1	1123504.JQKD01000117_gene390	3.475e-76	285.0	COG1120@1|root,COG2453@1|root,COG1120@2|Bacteria,COG2453@2|Bacteria,1P0GN@1224|Proteobacteria,2VNDH@28216|Betaproteobacteria,4AC63@80864|Comamonadaceae	28216|Betaproteobacteria	HPT	PFAM Dual specificity protein phosphatase	-	-	3.1.3.16,3.1.3.48	ko:K14165	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	ABC_tran,DSPc
HKD2_k127_5350943_9	1144275.COCOR_07324	1.654e-08	68.0	COG4753@1|root,COG4753@2|Bacteria,1MZAI@1224|Proteobacteria,4351T@68525|delta/epsilon subdivisions,2WZCT@28221|Deltaproteobacteria,2Z1UY@29|Myxococcales	28221|Deltaproteobacteria	T	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5350943_8	1123242.JH636436_gene762	3.572e-20	96.0	COG3829@1|root,COG3829@2|Bacteria,2J53D@203682|Planctomycetes	203682|Planctomycetes	KT	Two component, sigma54 specific, transcriptional regulator, Fis family protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Sigma54_activat
HKD2_k127_535165_1	1192034.CAP_2868	1.273e-45	169.0	COG0489@1|root,COG0489@2|Bacteria,1MU7R@1224|Proteobacteria,42NR0@68525|delta/epsilon subdivisions,2WIPG@28221|Deltaproteobacteria,2YU3H@29|Myxococcales	28221|Deltaproteobacteria	D	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP	mrp	-	-	ko:K03593	-	-	-	-	ko00000,ko03029,ko03036	-	-	-	FeS_assembly_P,ParA
HKD2_k127_535165_0	448385.sce7472	1.333e-78	268.0	COG0398@1|root,COG0398@2|Bacteria,1Q3TM@1224|Proteobacteria,4342Y@68525|delta/epsilon subdivisions,2X4YV@28221|Deltaproteobacteria,2YZV5@29|Myxococcales	28221|Deltaproteobacteria	S	SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
HKD2_k127_535165_2	448385.sce6513	1.135e-42	158.0	COG0714@1|root,COG0714@2|Bacteria,1MV5I@1224|Proteobacteria,42MTW@68525|delta/epsilon subdivisions,2WJ0J@28221|Deltaproteobacteria,2YUI8@29|Myxococcales	28221|Deltaproteobacteria	S	ATPase family associated with various cellular activities (AAA)	-	-	-	-	-	-	-	-	-	-	-	-	AAA,AAA_5
HKD2_k127_5352483_3	1121939.L861_17260	3.798e-38	156.0	COG1633@1|root,COG1633@2|Bacteria,1MXX8@1224|Proteobacteria,1SSIU@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)	-	-	-	-	-	-	-	-	-	-	-	-	AurF
HKD2_k127_5352483_2	448385.sce3353	4.246e-54	207.0	COG0404@1|root,COG0404@2|Bacteria	2|Bacteria	E	The glycine cleavage system catalyzes the degradation of glycine	gcvT1	-	2.1.2.10	ko:K00605,ko:K11053	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	GCV_T,GCV_T_C
HKD2_k127_5352483_4	448385.sce3352	1.595e-09	69.0	COG0236@1|root,COG0236@2|Bacteria	2|Bacteria	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	-	-	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
HKD2_k127_5352483_0	448385.sce3351	2.425e-136	458.0	COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,42MUZ@68525|delta/epsilon subdivisions,2WJT6@28221|Deltaproteobacteria,2YXTZ@29|Myxococcales	28221|Deltaproteobacteria	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	-	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
HKD2_k127_5352483_1	1173026.Glo7428_3239	5.623e-109	369.0	COG2124@1|root,COG2124@2|Bacteria,1G3SX@1117|Cyanobacteria	1117|Cyanobacteria	Q	Cytochrome p450	-	-	-	-	-	-	-	-	-	-	-	-	p450
HKD2_k127_5368713_1	1961.JOAK01000018_gene469	4.665e-11	75.0	COG0791@1|root,COG0791@2|Bacteria,2GPN4@201174|Actinobacteria	201174|Actinobacteria	M	NLP P60 protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5368713_0	1192034.CAP_5576	4.305e-25	106.0	COG1835@1|root,COG1835@2|Bacteria,1RFAU@1224|Proteobacteria,434WP@68525|delta/epsilon subdivisions,2WZ7M@28221|Deltaproteobacteria,2Z1I5@29|Myxococcales	28221|Deltaproteobacteria	I	Acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
HKD2_k127_5369582_2	1192034.CAP_8687	4.207e-30	125.0	2BUQR@1|root,32Q1U@2|Bacteria,1Q9JK@1224|Proteobacteria,434FE@68525|delta/epsilon subdivisions,2WYSW@28221|Deltaproteobacteria,2Z0IR@29|Myxococcales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF2505)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2505
HKD2_k127_5369582_1	1380391.JIAS01000013_gene3432	5.325e-39	158.0	2DK0G@1|root,30823@2|Bacteria,1RJF1@1224|Proteobacteria,2UAHF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Rifampin ADP-ribosyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	Arr-ms
HKD2_k127_5369582_0	1267533.KB906735_gene4610	2.297e-102	341.0	COG0524@1|root,COG0524@2|Bacteria,3Y61A@57723|Acidobacteria,2JKNA@204432|Acidobacteriia	204432|Acidobacteriia	G	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway	rbsK	-	2.7.1.15	ko:K00852	ko00030,map00030	-	R01051,R02750	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
HKD2_k127_5371565_0	448385.sce9025	8.018e-115	375.0	COG0443@1|root,COG0443@2|Bacteria,1MVEN@1224|Proteobacteria,42M64@68525|delta/epsilon subdivisions,2WIWS@28221|Deltaproteobacteria,2YUEK@29|Myxococcales	28221|Deltaproteobacteria	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
HKD2_k127_5371565_1	460265.Mnod_2578	1.511e-06	60.0	COG1287@1|root,COG1287@2|Bacteria,1N1IK@1224|Proteobacteria,2TUYH@28211|Alphaproteobacteria,1JU7G@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	oligosaccharyl transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_537558_3	378806.STAUR_2758	6.702e-35	154.0	COG0265@1|root,COG1266@1|root,COG0265@2|Bacteria,COG1266@2|Bacteria,1NMQX@1224|Proteobacteria,4334M@68525|delta/epsilon subdivisions,2WY91@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	CAAX amino terminal protease family	-	-	-	-	-	-	-	-	-	-	-	-	Abi,PDZ_2
HKD2_k127_537558_0	1254432.SCE1572_31170	6.2e-262	851.0	COG0515@1|root,COG2909@1|root,COG3899@1|root,COG0515@2|Bacteria,COG2909@2|Bacteria,COG3899@2|Bacteria,1QA6R@1224|Proteobacteria,438FC@68525|delta/epsilon subdivisions,2X3QC@28221|Deltaproteobacteria,2YWU9@29|Myxococcales	28221|Deltaproteobacteria	KLT	Family membership	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,Pkinase
HKD2_k127_537558_1	502025.Hoch_3713	3.481e-55	206.0	COG0823@1|root,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	Big_3_2,CARDB,F5_F8_type_C,FlgD_ig,PD40,Prenyltrans
HKD2_k127_5386599_4	448385.sce4487	1.269e-121	402.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,42RC9@68525|delta/epsilon subdivisions,2WN5U@28221|Deltaproteobacteria,2YWJ8@29|Myxococcales	28221|Deltaproteobacteria	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HKD2_k127_5386599_15	1281779.H009_02543	9.001e-21	100.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TR8X@28211|Alphaproteobacteria,4B8J8@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	Signal transduction histidine kinase regulating C4-dicarboxylate transport system	dctB	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	2.7.13.3	ko:K10125	ko02020,map02020	M00504	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,dCache_1
HKD2_k127_5386599_0	448385.sce7212	1.923e-233	755.0	COG0515@1|root,COG0515@2|Bacteria,1QA6R@1224|Proteobacteria	448385.sce7212|-	KLT	serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5386599_10	1192034.CAP_1551	1.429e-62	246.0	COG1266@1|root,COG1266@2|Bacteria,1NHPM@1224|Proteobacteria,4384U@68525|delta/epsilon subdivisions,2X9XI@28221|Deltaproteobacteria,2YVRP@29|Myxococcales	28221|Deltaproteobacteria	S	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
HKD2_k127_5386599_7	1254432.SCE1572_43960	1.23e-85	288.0	COG0560@1|root,COG0560@2|Bacteria,1MWTU@1224|Proteobacteria,43BHJ@68525|delta/epsilon subdivisions,2X6W0@28221|Deltaproteobacteria,2Z3D8@29|Myxococcales	28221|Deltaproteobacteria	E	haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD
HKD2_k127_5386599_2	448385.sce6587	2.214e-198	625.0	COG0112@1|root,COG0112@2|Bacteria,1MUIS@1224|Proteobacteria,42M0T@68525|delta/epsilon subdivisions,2WJ3C@28221|Deltaproteobacteria,2YTTC@29|Myxococcales	28221|Deltaproteobacteria	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
HKD2_k127_5386599_6	926549.KI421517_gene1315	1.973e-86	292.0	COG3967@1|root,COG3967@2|Bacteria,4NJUM@976|Bacteroidetes,47MKC@768503|Cytophagia	976|Bacteroidetes	M	KR domain	-	-	-	ko:K14189	-	-	-	-	ko00000,ko01000	-	-	-	adh_short
HKD2_k127_5386599_8	448385.sce5636	4.177e-84	297.0	COG0515@1|root,COG0515@2|Bacteria,1PJRR@1224|Proteobacteria	1224|Proteobacteria	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	DUF4384,PEGA,Pkinase,TPR_12
HKD2_k127_5386599_9	1192034.CAP_5644	1.273e-70	256.0	2ANIU@1|root,31DHW@2|Bacteria,1QATB@1224|Proteobacteria,435AE@68525|delta/epsilon subdivisions,2WZMG@28221|Deltaproteobacteria,2Z2DG@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5386599_3	1192034.CAP_8261	4.937e-133	435.0	COG2723@1|root,COG2723@2|Bacteria,1MWG6@1224|Proteobacteria,42UR5@68525|delta/epsilon subdivisions,2WQET@28221|Deltaproteobacteria,2YU27@29|Myxococcales	28221|Deltaproteobacteria	G	Belongs to the glycosyl hydrolase 1 family	-	-	3.2.1.21	ko:K05350	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_1
HKD2_k127_5386599_13	378806.STAUR_5481	2.006e-26	117.0	COG1881@1|root,COG1881@2|Bacteria,1RHPA@1224|Proteobacteria,43ANZ@68525|delta/epsilon subdivisions	1224|Proteobacteria	S	Phosphatidylethanolamine-binding protein	-	-	-	ko:K06910	-	-	-	-	ko00000	-	-	-	PBP
HKD2_k127_5386599_12	1313172.YM304_11060	8.463e-38	157.0	2DB7V@1|root,2Z7NX@2|Bacteria,2I9CJ@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5386599_11	448385.sce7348	1.496e-62	227.0	COG0149@1|root,COG0149@2|Bacteria,1MWK5@1224|Proteobacteria,42MIF@68525|delta/epsilon subdivisions,2WIQF@28221|Deltaproteobacteria,2YU88@29|Myxococcales	28221|Deltaproteobacteria	G	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)	tpiA	-	5.3.1.1	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01015	RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	TIM
HKD2_k127_5386599_5	1499967.BAYZ01000152_gene1435	3.545e-108	370.0	COG0205@1|root,COG0205@2|Bacteria,2NNY2@2323|unclassified Bacteria	2|Bacteria	G	Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis	pfkA	-	2.7.1.11	ko:K00850	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230	M00001,M00345	R00756,R03236,R03237,R03238,R03239,R04779	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000,ko01009,ko03019	-	-	-	PFK
HKD2_k127_5386599_16	1458357.BG58_23145	6.898e-12	74.0	COG1633@1|root,COG1633@2|Bacteria,1RGZG@1224|Proteobacteria,2VSVM@28216|Betaproteobacteria,1K16X@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Domain of unknown function (DUF2383)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2383
HKD2_k127_5386599_1	1254432.SCE1572_36710	8.183e-227	718.0	COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,42M52@68525|delta/epsilon subdivisions,2WIRK@28221|Deltaproteobacteria,2YUQN@29|Myxococcales	28221|Deltaproteobacteria	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	-	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
HKD2_k127_5386974_0	1192034.CAP_3397	1.353e-79	273.0	COG0272@1|root,COG0272@2|Bacteria,1MV3R@1224|Proteobacteria,42MC5@68525|delta/epsilon subdivisions,2WIT5@28221|Deltaproteobacteria,2YU7A@29|Myxococcales	28221|Deltaproteobacteria	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	-	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_aden,HHH_5
HKD2_k127_5386974_1	290397.Adeh_3956	8.5e-44	166.0	2A9VF@1|root,30Z3B@2|Bacteria,1PKZS@1224|Proteobacteria,435JG@68525|delta/epsilon subdivisions,2WZXJ@28221|Deltaproteobacteria,2Z0YG@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5388910_0	448385.sce5827	1.231e-93	317.0	COG0515@1|root,COG0515@2|Bacteria,1P2EB@1224|Proteobacteria,438NX@68525|delta/epsilon subdivisions,2X8TD@28221|Deltaproteobacteria,2YXD6@29|Myxococcales	28221|Deltaproteobacteria	KLT	Protein kinase domain	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
HKD2_k127_5388910_1	1192034.CAP_1428	1.328e-60	216.0	COG3285@1|root,COG3285@2|Bacteria,1MVWY@1224|Proteobacteria,42U99@68525|delta/epsilon subdivisions,2WQ5W@28221|Deltaproteobacteria,2YWMR@29|Myxococcales	28221|Deltaproteobacteria	L	ATP dependent DNA ligase domain protein	-	-	6.5.1.1	ko:K01971	ko03450,map03450	-	R00381	RC00005	ko00000,ko00001,ko01000,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,LigD_N
HKD2_k127_5389906_2	448385.sce6069	4.58e-139	454.0	COG2425@1|root,COG2425@2|Bacteria,1Q5ER@1224|Proteobacteria,4341B@68525|delta/epsilon subdivisions,2X4M9@28221|Deltaproteobacteria,2YZ8P@29|Myxococcales	28221|Deltaproteobacteria	S	protein containing a von Willebrand factor type A (vWA) domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5389906_9	189425.PGRAT_12890	1.368e-07	63.0	2ASZS@1|root,31IFG@2|Bacteria,1V50D@1239|Firmicutes,4HZ96@91061|Bacilli,26R48@186822|Paenibacillaceae	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5389906_4	1254432.SCE1572_02715	2.14e-92	334.0	COG0515@1|root,COG0515@2|Bacteria,1Q38J@1224|Proteobacteria,438ZJ@68525|delta/epsilon subdivisions,2X44T@28221|Deltaproteobacteria,2YY98@29|Myxococcales	28221|Deltaproteobacteria	KLT	Protein kinase domain	masK	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HKD2_k127_5389906_7	1192034.CAP_3356	5.04e-50	194.0	COG0457@1|root,COG0457@2|Bacteria	1192034.CAP_3356|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5389906_0	1192034.CAP_4619	7.432e-204	653.0	COG0823@1|root,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,PA14,PD40,PKD
HKD2_k127_5389906_3	1192034.CAP_4442	2.577e-99	334.0	COG0515@1|root,COG0515@2|Bacteria	1192034.CAP_4442|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5389906_6	378806.STAUR_7283	9.133e-51	200.0	COG3744@1|root,COG3744@2|Bacteria,1NY7K@1224|Proteobacteria,4380D@68525|delta/epsilon subdivisions,2X3AF@28221|Deltaproteobacteria,2YV4N@29|Myxococcales	28221|Deltaproteobacteria	S	PilT protein domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5389906_1	1121920.AUAU01000018_gene1829	7.663e-161	520.0	COG1271@1|root,COG1271@2|Bacteria,3Y44V@57723|Acidobacteria	57723|Acidobacteria	C	Cytochrome bd terminal oxidase subunit I	-	-	1.10.3.14	ko:K00425	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	Cyt_bd_oxida_I
HKD2_k127_5389906_5	903818.KI912268_gene1834	3.23e-76	271.0	COG1294@1|root,COG1294@2|Bacteria,3Y3UT@57723|Acidobacteria	57723|Acidobacteria	C	Cytochrome d ubiquinol oxidase, subunit II	-	-	1.10.3.14	ko:K00426	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	Cyt_bd_oxida_II
HKD2_k127_5389906_8	1192034.CAP_4696	2.581e-21	93.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,42QAU@68525|delta/epsilon subdivisions,2WMD2@28221|Deltaproteobacteria,2YUNE@29|Myxococcales	28221|Deltaproteobacteria	C	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	ko:K11731	ko00281,map00281	-	R08089	RC01893	ko00000,ko00001,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HKD2_k127_5390738_0	448385.sce4007	1.3e-155	504.0	COG1716@1|root,COG2204@1|root,COG1716@2|Bacteria,COG2204@2|Bacteria	2|Bacteria	T	phosphorelay signal transduction system	-	-	4.6.1.1	ko:K01768,ko:K10941,ko:K11894	ko00230,ko02020,ko02025,ko04113,ko04213,ko05111,map00230,map02020,map02025,map04113,map04213,map05111	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000,ko02044,ko03000	3.A.23.1	-	-	FHA,GAF_2,HTH_8,Sigma54_activat,Yop-YscD_cpl
HKD2_k127_5390738_2	1192034.CAP_4442	3.523e-95	329.0	COG0515@1|root,COG0515@2|Bacteria	1192034.CAP_4442|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5390738_3	1192034.CAP_2119	5.987e-48	177.0	COG2353@1|root,COG2353@2|Bacteria,1PBC0@1224|Proteobacteria,43332@68525|delta/epsilon subdivisions,2WX6Z@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	YceI-like domain	-	-	-	-	-	-	-	-	-	-	-	-	YceI
HKD2_k127_5390738_4	1192034.CAP_2118	3.736e-45	179.0	COG2010@1|root,COG2010@2|Bacteria,1PD95@1224|Proteobacteria,43E5K@68525|delta/epsilon subdivisions,2WZSQ@28221|Deltaproteobacteria,2Z2P1@29|Myxococcales	28221|Deltaproteobacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5390738_1	1192034.CAP_4442	4.842e-111	376.0	COG0515@1|root,COG0515@2|Bacteria	1192034.CAP_4442|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5390738_5	1254432.SCE1572_04345	2.761e-29	117.0	COG0029@1|root,COG0029@2|Bacteria,1RBQW@1224|Proteobacteria,43BKD@68525|delta/epsilon subdivisions,2WJNK@28221|Deltaproteobacteria,2YUGG@29|Myxococcales	28221|Deltaproteobacteria	H	Catalyzes the oxidation of L-aspartate to iminoaspartate	nadB	-	1.4.3.16	ko:K00278	ko00250,ko00760,ko01100,map00250,map00760,map01100	M00115	R00357,R00481	RC00006,RC02566	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
HKD2_k127_5394266_0	1379698.RBG1_1C00001G0024	8.901e-98	328.0	COG0649@1|root,COG0649@2|Bacteria	2|Bacteria	C	NAD binding	nuoD	GO:0003674,GO:0003824,GO:0003954,GO:0008137,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114	1.6.5.3	ko:K00333,ko:K05579,ko:K13378	ko00190,ko01100,map00190,map01100	M00144,M00145	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa,Complex1_49kDa
HKD2_k127_5394266_1	552811.Dehly_0835	4.571e-62	227.0	COG1005@1|root,COG1005@2|Bacteria,2G60S@200795|Chloroflexi,34CTC@301297|Dehalococcoidia	301297|Dehalococcoidia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	nuoH	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
HKD2_k127_5396368_6	1192034.CAP_0341	1.994e-13	72.0	COG0848@1|root,COG0848@2|Bacteria,1N8FU@1224|Proteobacteria,42WU3@68525|delta/epsilon subdivisions,2WSMD@28221|Deltaproteobacteria,2YW1Y@29|Myxococcales	28221|Deltaproteobacteria	U	Biopolymer transport protein ExbD/TolR	-	-	-	-	-	-	-	-	-	-	-	-	ExbD
HKD2_k127_5396368_2	502025.Hoch_4800	6.299e-50	193.0	COG2972@1|root,COG2972@2|Bacteria,1MXVQ@1224|Proteobacteria,42R4U@68525|delta/epsilon subdivisions,2X799@28221|Deltaproteobacteria,2Z0XB@29|Myxococcales	28221|Deltaproteobacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K08082	ko02020,map02020	M00493	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,His_kinase
HKD2_k127_5396368_3	391625.PPSIR1_20324	2.809e-45	184.0	COG3279@1|root,COG3279@2|Bacteria,1MVJI@1224|Proteobacteria,43ADC@68525|delta/epsilon subdivisions,2X5T8@28221|Deltaproteobacteria,2Z38R@29|Myxococcales	28221|Deltaproteobacteria	K	LytTr DNA-binding domain	lytT	-	-	ko:K02477,ko:K07705	ko02020,map02020	M00492	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	LytTR,Response_reg
HKD2_k127_5396368_4	1040989.AWZU01000005_gene159	3.433e-45	166.0	COG3795@1|root,COG3795@2|Bacteria,1RCZT@1224|Proteobacteria,2U735@28211|Alphaproteobacteria,3JY2H@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	YCII-related domain	MA20_04055	-	-	-	-	-	-	-	-	-	-	-	YCII
HKD2_k127_5396368_0	1144275.COCOR_05894	3.503e-170	545.0	COG4941@1|root,COG4941@2|Bacteria,1MU3D@1224|Proteobacteria,437V1@68525|delta/epsilon subdivisions,2X34I@28221|Deltaproteobacteria,2YU7X@29|Myxococcales	28221|Deltaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD2_k127_5396368_5	448385.sce5426	2.372e-42	160.0	2DHHJ@1|root,2ZZT4@2|Bacteria,1P8VN@1224|Proteobacteria,437HA@68525|delta/epsilon subdivisions,2WYJV@28221|Deltaproteobacteria,2Z0XT@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5396368_1	1254432.SCE1572_05070	5.341e-75	264.0	COG0583@1|root,COG0583@2|Bacteria,1N8HK@1224|Proteobacteria	1224|Proteobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HKD2_k127_5403463_4	504472.Slin_3210	3.096e-69	243.0	28HII@1|root,2Z7TZ@2|Bacteria,4NHR6@976|Bacteroidetes,47MJR@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5403463_10	448385.sce9302	1.137e-29	123.0	COG4911@1|root,COG4911@2|Bacteria,1QCSX@1224|Proteobacteria,4387P@68525|delta/epsilon subdivisions,2X3HG@28221|Deltaproteobacteria,2YW4D@29|Myxococcales	28221|Deltaproteobacteria	S	Uncharacterized conserved protein (DUF2203)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2203
HKD2_k127_5403463_9	1254432.SCE1572_52445	1.138e-36	149.0	COG0302@1|root,COG0302@2|Bacteria,1MY3N@1224|Proteobacteria,42N1U@68525|delta/epsilon subdivisions,2X2RV@28221|Deltaproteobacteria,2YW4J@29|Myxococcales	28221|Deltaproteobacteria	H	GTP cyclohydrolase I	folE	-	3.5.4.16	ko:K01495	ko00790,ko01100,map00790,map01100	M00126,M00841,M00842,M00843	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	-	GTP_cyclohydroI
HKD2_k127_5403463_5	1254432.SCE1572_52440	9.705e-65	237.0	COG1028@1|root,COG1028@2|Bacteria,1MU6X@1224|Proteobacteria,42MB9@68525|delta/epsilon subdivisions,2WJ64@28221|Deltaproteobacteria,2Z0DF@29|Myxococcales	28221|Deltaproteobacteria	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short,adh_short_C2
HKD2_k127_5403463_8	1254432.SCE1572_52435	9.186e-51	197.0	COG2802@1|root,COG2802@2|Bacteria,1Q90Z@1224|Proteobacteria,43426@68525|delta/epsilon subdivisions,2X4S2@28221|Deltaproteobacteria,2YVIH@29|Myxococcales	28221|Deltaproteobacteria	S	ATP-dependent protease La (LON) substrate-binding domain	-	-	3.4.21.53	ko:K01338,ko:K07157	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	LON_substr_bdg
HKD2_k127_5403463_12	686340.Metal_1187	4.841e-09	61.0	COG2146@1|root,COG2146@2|Bacteria,1N8PE@1224|Proteobacteria,1SAAA@1236|Gammaproteobacteria,1XFCJ@135618|Methylococcales	135618|Methylococcales	P	Rieske 2Fe-2S	-	-	-	ko:K05710	ko00360,ko01120,ko01220,map00360,map01120,map01220	M00545	R06782,R06783	RC00098	br01602,ko00000,ko00001,ko00002	-	-	-	Rieske
HKD2_k127_5403463_3	448385.sce7577	4.924e-91	324.0	COG1408@1|root,COG1408@2|Bacteria,1MUH5@1224|Proteobacteria,42N75@68525|delta/epsilon subdivisions,2WKJY@28221|Deltaproteobacteria,2Z2YT@29|Myxococcales	28221|Deltaproteobacteria	S	Calcineurin-like phosphoesterase	-	-	-	ko:K07098	-	-	-	-	ko00000	-	-	-	Metallophos
HKD2_k127_5403463_6	1192034.CAP_8031	1.098e-56	210.0	COG0667@1|root,COG0667@2|Bacteria,1NWQE@1224|Proteobacteria,42ZW2@68525|delta/epsilon subdivisions,2WVDI@28221|Deltaproteobacteria,2YVXI@29|Myxococcales	28221|Deltaproteobacteria	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red,HEAT_2
HKD2_k127_5403463_2	526225.Gobs_2652	1.263e-93	322.0	COG1819@1|root,COG1819@2|Bacteria,2GJN7@201174|Actinobacteria,4EU7I@85013|Frankiales	201174|Actinobacteria	CG	UDP-glucoronosyl and UDP-glucosyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tran_28_C,UDPGT
HKD2_k127_5403463_7	1192034.CAP_7281	5.083e-52	192.0	COG3757@1|root,COG3757@2|Bacteria,1N792@1224|Proteobacteria,432YH@68525|delta/epsilon subdivisions	1224|Proteobacteria	M	Glycosyl hydrolases family 25	yegX	-	-	ko:K07273	-	-	-	-	ko00000	-	-	-	Glyco_hydro_25
HKD2_k127_5403463_0	1192034.CAP_0326	1.588e-222	724.0	2DG6Z@1|root,2ZUS9@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5403463_1	290397.Adeh_2112	3.106e-126	413.0	COG4108@1|root,COG4108@2|Bacteria,1MU7X@1224|Proteobacteria,42MAA@68525|delta/epsilon subdivisions,2WJZC@28221|Deltaproteobacteria,2YUE7@29|Myxococcales	28221|Deltaproteobacteria	J	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP	prfC	GO:0003674,GO:0003676,GO:0003723,GO:0003747,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0016150,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K02837	-	-	-	-	ko00000,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,RF3_C
HKD2_k127_5411353_0	1192034.CAP_2387	4.913e-234	779.0	COG1629@1|root,COG4771@2|Bacteria,1MUC1@1224|Proteobacteria,42R8H@68525|delta/epsilon subdivisions,2WMWF@28221|Deltaproteobacteria,2YUND@29|Myxococcales	28221|Deltaproteobacteria	P	PEGA domain	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	PEGA,Plug,TonB_dep_Rec
HKD2_k127_5411353_2	448385.sce4512	1.743e-91	318.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,42MVV@68525|delta/epsilon subdivisions,2X4JB@28221|Deltaproteobacteria,2YZ4I@29|Myxococcales	28221|Deltaproteobacteria	KLT	Family membership	-	-	2.7.11.1	ko:K08884	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HKD2_k127_5411353_1	1192034.CAP_8870	7.281e-138	457.0	COG0661@1|root,COG0661@2|Bacteria,1NXB8@1224|Proteobacteria,43B1X@68525|delta/epsilon subdivisions,2X6FZ@28221|Deltaproteobacteria,2Z3AW@29|Myxococcales	28221|Deltaproteobacteria	C	ABC1 family	-	-	-	-	-	-	-	-	-	-	-	-	ABC1
HKD2_k127_5411353_3	448385.sce3392	2.231e-09	69.0	COG2304@1|root,COG2304@2|Bacteria	2|Bacteria	IU	oxidoreductase activity	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VWA,VWA_2
HKD2_k127_5414323_3	827.JFJK01000009_gene1321	0.000541	51.0	COG0760@1|root,COG0760@2|Bacteria,1MZDK@1224|Proteobacteria,43B2E@68525|delta/epsilon subdivisions,2YN33@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	M	peptidylprolyl isomerase	peb4	-	5.2.1.8	ko:K01802	-	-	-	-	ko00000,ko01000	-	-	-	Rotamase,Rotamase_2,Rotamase_3,SurA_N_3
HKD2_k127_5414323_0	448385.sce2965	4.092e-131	433.0	COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,42NYP@68525|delta/epsilon subdivisions,2WIPJ@28221|Deltaproteobacteria,2YUUX@29|Myxococcales	28221|Deltaproteobacteria	S	Belongs to the peptidase M16 family	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
HKD2_k127_5414323_1	1254432.SCE1572_30445	1.374e-78	278.0	COG2267@1|root,COG2267@2|Bacteria,1QTAP@1224|Proteobacteria,434HT@68525|delta/epsilon subdivisions,2WYV2@28221|Deltaproteobacteria,2Z0PY@29|Myxococcales	28221|Deltaproteobacteria	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
HKD2_k127_5414323_2	448385.sce6432	5.024e-60	218.0	COG0473@1|root,COG0473@2|Bacteria,1QU2H@1224|Proteobacteria,43B0A@68525|delta/epsilon subdivisions,2X6EE@28221|Deltaproteobacteria,2YUMP@29|Myxococcales	28221|Deltaproteobacteria	C	Dehydrogenase	leuB2	-	1.1.1.41,1.1.1.85	ko:K00030,ko:K00052	ko00020,ko00290,ko00660,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00290,map00660,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00432,M00535	R00709,R00994,R04426,R10052	RC00084,RC00114,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
HKD2_k127_5426527_4	448385.sce0258	4.31e-14	72.0	COG0718@1|root,COG0718@2|Bacteria,1RGZD@1224|Proteobacteria,42TGQ@68525|delta/epsilon subdivisions,2WQ6R@28221|Deltaproteobacteria,2YW2J@29|Myxococcales	28221|Deltaproteobacteria	S	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection	-	-	-	ko:K09747	-	-	-	-	ko00000	-	-	-	YbaB_DNA_bd
HKD2_k127_5426527_0	585198.HMPREF0574_1253	6.818e-54	198.0	COG0353@1|root,COG0353@2|Bacteria,2GJY0@201174|Actinobacteria,4D44Y@85005|Actinomycetales	201174|Actinobacteria	L	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO	recR	-	-	ko:K06187	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	HHH,RecR,Toprim_4
HKD2_k127_5426527_1	429009.Adeg_0109	3.578e-42	158.0	COG0251@1|root,COG0251@2|Bacteria,1V6HG@1239|Firmicutes,24J8Y@186801|Clostridia,42GJ3@68295|Thermoanaerobacterales	186801|Clostridia	J	PFAM Endoribonuclease L-PSP	yjgF	-	3.5.99.10	ko:K09022	-	-	R11098,R11099	RC03275,RC03354	ko00000,ko01000	-	-	-	Ribonuc_L-PSP
HKD2_k127_5426527_2	1192034.CAP_3167	4.117e-40	163.0	COG0115@1|root,COG0115@2|Bacteria,1MVB0@1224|Proteobacteria,42MKX@68525|delta/epsilon subdivisions,2WQC6@28221|Deltaproteobacteria,2YV64@29|Myxococcales	28221|Deltaproteobacteria	EH	Aminotransferase	-	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
HKD2_k127_5426527_3	525897.Dbac_1061	2.38e-30	127.0	COG2121@1|root,COG2121@2|Bacteria,1MZID@1224|Proteobacteria,42UW6@68525|delta/epsilon subdivisions,2WQ4A@28221|Deltaproteobacteria,2MC4T@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF374)	-	-	-	ko:K09778	-	-	-	-	ko00000	-	-	-	DUF374
HKD2_k127_5433740_3	448385.sce2921	1.332e-68	236.0	COG0457@1|root,COG2956@1|root,COG3071@1|root,COG0457@2|Bacteria,COG2956@2|Bacteria,COG3071@2|Bacteria,1MVIW@1224|Proteobacteria,437VP@68525|delta/epsilon subdivisions,2WWNT@28221|Deltaproteobacteria,2YUC4@29|Myxococcales	28221|Deltaproteobacteria	G	repeat protein	agmK	-	-	-	-	-	-	-	-	-	-	-	TPR_19,TPR_6,TPR_7,TPR_8
HKD2_k127_5433740_4	1049564.TevJSym_ae00760	5.224e-51	201.0	COG3303@1|root,COG3303@2|Bacteria,1P8CP@1224|Proteobacteria,1RQGG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Seven times multi-haem cytochrome CxxCH	-	-	1.7.2.6	ko:K10535	ko00910,ko01120,map00910,map01120	M00528,M00804	R10164	RC00383	ko00000,ko00001,ko00002,ko01000	-	-	-	Multi-haem_cyto
HKD2_k127_5433740_9	937777.Deipe_0803	0.0003866	53.0	COG0457@1|root,COG0457@2|Bacteria,1WJ9G@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	PFAM Cytochrome C	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3,TPR_11,TPR_16,TPR_19,TPR_8
HKD2_k127_5433740_1	1254432.SCE1572_22815	1.884e-75	269.0	COG1716@1|root,COG2204@1|root,COG1716@2|Bacteria,COG2204@2|Bacteria	2|Bacteria	T	phosphorelay signal transduction system	CP_0034	-	4.6.1.1	ko:K01768,ko:K10941,ko:K21405	ko00230,ko02020,ko02025,ko04113,ko04213,ko05111,map00230,map02020,map02025,map04113,map04213,map05111	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000,ko03000	-	-	-	BON,FHA,FTSW_RODA_SPOVE,HTH_8,Sigma54_activat,Yop-YscD_cpl
HKD2_k127_5433740_7	1192034.CAP_6952	5.546e-25	118.0	COG0457@1|root,COG0457@2|Bacteria	1192034.CAP_6952|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5433740_0	448385.sce3789	4.932e-101	350.0	COG0860@1|root,COG0860@2|Bacteria,1MUQK@1224|Proteobacteria,42MPH@68525|delta/epsilon subdivisions,2WJHW@28221|Deltaproteobacteria,2Z0ST@29|Myxococcales	28221|Deltaproteobacteria	M	Ami_3	amiC	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	AMIN,Amidase_3,TPR_6
HKD2_k127_5433740_11	1463917.JODC01000021_gene9185	0.0008164	48.0	COG2197@1|root,COG2197@2|Bacteria,2GJ46@201174|Actinobacteria	201174|Actinobacteria	T	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HKD2_k127_5433740_10	479432.Sros_6137	0.0005155	46.0	COG2197@1|root,COG2197@2|Bacteria,2GN29@201174|Actinobacteria,4EI3F@85012|Streptosporangiales	201174|Actinobacteria	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HKD2_k127_5433740_2	1254432.SCE1572_22745	4.694e-70	248.0	COG0494@1|root,COG0494@2|Bacteria,1NTFG@1224|Proteobacteria,43CZF@68525|delta/epsilon subdivisions,2X87P@28221|Deltaproteobacteria,2Z2KS@29|Myxococcales	28221|Deltaproteobacteria	L	NUDIX hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5433740_6	448385.sce8126	4.049e-38	149.0	2BPA6@1|root,32I21@2|Bacteria,1Q1NP@1224|Proteobacteria,437D0@68525|delta/epsilon subdivisions,2X2J2@28221|Deltaproteobacteria,2YVZ4@29|Myxococcales	28221|Deltaproteobacteria	S	Cytosol aminopeptidase family, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M17_N
HKD2_k127_5433740_8	1254432.SCE1572_42360	1.214e-20	92.0	COG0781@1|root,COG0781@2|Bacteria,1N94P@1224|Proteobacteria,42SEA@68525|delta/epsilon subdivisions,2WQP9@28221|Deltaproteobacteria,2YVKR@29|Myxococcales	28221|Deltaproteobacteria	K	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons	nusB	-	-	ko:K03625	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	NusB
HKD2_k127_5434636_7	1192034.CAP_2400	1.045e-11	73.0	COG3221@1|root,COG3221@2|Bacteria,1MXD8@1224|Proteobacteria,42VZ4@68525|delta/epsilon subdivisions,2WRDI@28221|Deltaproteobacteria,2YW4T@29|Myxococcales	28221|Deltaproteobacteria	P	ABC transporter, phosphonate, periplasmic substrate-binding protein	phnD	-	-	ko:K02044	ko02010,map02010	M00223	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.9	-	-	Phosphonate-bd
HKD2_k127_5434636_3	1192034.CAP_3347	1.349e-132	437.0	COG0534@1|root,COG0534@2|Bacteria	2|Bacteria	V	drug transmembrane transporter activity	norM_1	-	-	ko:K03327	-	-	-	-	ko00000,ko02000	2.A.66.1	-	-	MatE
HKD2_k127_5434636_6	1254432.SCE1572_04385	3.194e-20	100.0	COG2885@1|root,COG2885@2|Bacteria,1QAG8@1224|Proteobacteria,4352E@68525|delta/epsilon subdivisions,2WZDB@28221|Deltaproteobacteria,2Z1W3@29|Myxococcales	28221|Deltaproteobacteria	M	Belongs to the ompA family	-	-	-	ko:K03640	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	OmpA
HKD2_k127_5434636_2	448385.sce2960	9.311e-202	660.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,4399Y@68525|delta/epsilon subdivisions,2X4HE@28221|Deltaproteobacteria,2YZ0V@29|Myxococcales	28221|Deltaproteobacteria	KLT	Protein kinase; unclassified specificity.	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HKD2_k127_5434636_1	448385.sce5603	2.205e-233	736.0	COG0281@1|root,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,42MDI@68525|delta/epsilon subdivisions,2WIVY@28221|Deltaproteobacteria,2YVVP@29|Myxococcales	28221|Deltaproteobacteria	C	Malic enzyme, NAD binding domain	-	-	1.1.1.38	ko:K00027	ko00620,ko01200,ko02020,map00620,map01200,map02020	-	R00214	RC00105	ko00000,ko00001,ko01000	-	-	-	Malic_M,malic
HKD2_k127_5434636_4	1192034.CAP_6237	6.041e-46	182.0	COG5164@1|root,COG5164@2|Bacteria,1R0C5@1224|Proteobacteria,43CUH@68525|delta/epsilon subdivisions,2X826@28221|Deltaproteobacteria,2Z24H@29|Myxococcales	28221|Deltaproteobacteria	K	regulation of DNA-templated transcription, elongation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5434636_0	1125863.JAFN01000001_gene353	0.0	1268.0	COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,42MGK@68525|delta/epsilon subdivisions,2WJQH@28221|Deltaproteobacteria	28221|Deltaproteobacteria	F	Belongs to the CarB family	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
HKD2_k127_5453148_1	448385.sce1772	1.457e-69	236.0	COG2718@1|root,COG2718@2|Bacteria,1MWQM@1224|Proteobacteria,42PDK@68525|delta/epsilon subdivisions,2WJKJ@28221|Deltaproteobacteria,2YTX7@29|Myxococcales	28221|Deltaproteobacteria	S	Belongs to the UPF0229 family	-	-	-	ko:K09786	-	-	-	-	ko00000	-	-	-	DUF444
HKD2_k127_5453148_2	1242864.D187_001382	4.733e-14	83.0	COG1360@1|root,COG1360@2|Bacteria,1QXT9@1224|Proteobacteria,43C5P@68525|delta/epsilon subdivisions,2X7FY@28221|Deltaproteobacteria,2Z3FZ@29|Myxococcales	28221|Deltaproteobacteria	N	Domain of unknown function (DUF4398)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4398,OmpA
HKD2_k127_5453148_3	448385.sce5307	8.098e-08	59.0	2AEYE@1|root,314WB@2|Bacteria,1PUU5@1224|Proteobacteria,434MW@68525|delta/epsilon subdivisions,2WYZA@28221|Deltaproteobacteria,2Z0ZG@29|Myxococcales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF4398)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4398
HKD2_k127_5453148_0	383372.Rcas_1381	4.496e-229	731.0	COG2719@1|root,COG2719@2|Bacteria,2G83B@200795|Chloroflexi,376XP@32061|Chloroflexia	32061|Chloroflexia	S	PFAM SpoVR family protein	-	-	-	ko:K06415	-	-	-	-	ko00000	-	-	-	SpoVR
HKD2_k127_5454161_4	502025.Hoch_0069	6.386e-39	148.0	COG0639@1|root,COG4103@1|root,COG0639@2|Bacteria,COG4103@2|Bacteria,1NJ9V@1224|Proteobacteria,438VE@68525|delta/epsilon subdivisions,2X417@28221|Deltaproteobacteria,2YXWH@29|Myxococcales	28221|Deltaproteobacteria	T	Protein phosphatase 2A homologues, catalytic domain.	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
HKD2_k127_5454161_14	246969.TAM4_499	0.0008533	51.0	COG0515@1|root,arCOG00372@1|root,arCOG03264@1|root,arCOG00372@2157|Archaea,arCOG03264@2157|Archaea,arCOG03682@2157|Archaea,2XWYZ@28890|Euryarchaeota,2437Z@183968|Thermococci	183968|Thermococci	T	Protein tyrosine kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
HKD2_k127_5454161_7	1254432.SCE1572_17370	1.841e-08	68.0	COG3386@1|root,COG3386@2|Bacteria	2|Bacteria	G	gluconolactonase activity	-	-	3.1.1.17	ko:K01053	ko00030,ko00053,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,map00030,map00053,map00930,map01100,map01110,map01120,map01130,map01200,map01220	M00129	R01519,R02933,R03751	RC00537,RC00983	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	SGL
HKD2_k127_5454161_5	448385.sce2826	2.763e-27	125.0	COG0457@1|root,COG0457@2|Bacteria,1R0CA@1224|Proteobacteria,43EDM@68525|delta/epsilon subdivisions,2X82F@28221|Deltaproteobacteria,2Z26J@29|Myxococcales	28221|Deltaproteobacteria	S	PEGA domain	-	-	-	-	-	-	-	-	-	-	-	-	PEGA
HKD2_k127_5454161_2	448385.sce4512	7.88e-59	231.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,42MVV@68525|delta/epsilon subdivisions,2X4JB@28221|Deltaproteobacteria,2YZ4I@29|Myxococcales	28221|Deltaproteobacteria	KLT	Family membership	-	-	2.7.11.1	ko:K08884	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HKD2_k127_5454161_1	1206741.BAFX01000048_gene3281	2.856e-107	359.0	2DB8Y@1|root,2Z7TF@2|Bacteria,2GNYD@201174|Actinobacteria,4FU1S@85025|Nocardiaceae	201174|Actinobacteria	S	Uncharacterized protein conserved in bacteria (DUF2236)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2236
HKD2_k127_5454161_13	1282876.BAOK01000001_gene1582	0.0001814	51.0	COG1846@1|root,COG1846@2|Bacteria,1PVT1@1224|Proteobacteria,2UU1W@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	MarR_2
HKD2_k127_5454161_12	420324.KI912020_gene7620	4.05e-05	53.0	COG1595@1|root,COG1595@2|Bacteria,1MZMC@1224|Proteobacteria,2U8V4@28211|Alphaproteobacteria,1JU8M@119045|Methylobacteriaceae	28211|Alphaproteobacteria	K	TIGRFAM RNA polymerase sigma factor, sigma-70 family	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD2_k127_5454161_9	1234364.AMSF01000053_gene1312	2.726e-07	62.0	COG3712@1|root,COG3712@2|Bacteria,1MZCK@1224|Proteobacteria,1S66V@1236|Gammaproteobacteria,1X5Z5@135614|Xanthomonadales	135614|Xanthomonadales	PT	FecR protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF4880,DUF4974,FecR
HKD2_k127_5454161_8	1254432.SCE1572_07440	1.896e-08	67.0	COG4935@1|root,COG4935@2|Bacteria,1QZT5@1224|Proteobacteria,42YUM@68525|delta/epsilon subdivisions	1224|Proteobacteria	O	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5454161_0	517418.Ctha_1907	3.217e-235	763.0	COG0612@1|root,COG0612@2|Bacteria	2|Bacteria	L	Peptidase, M16	pqqL	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
HKD2_k127_5454161_3	204669.Acid345_0731	8.837e-54	207.0	COG3511@1|root,COG3511@2|Bacteria,3Y7AQ@57723|Acidobacteria,2JM7S@204432|Acidobacteriia	2|Bacteria	M	Phosphoesterase family	-	-	3.1.4.3	ko:K01114	ko00562,ko00564,ko00565,ko01100,ko01110,ko02024,ko04919,map00562,map00564,map00565,map01100,map01110,map02024,map04919	-	R01312,R02027,R02052,R03332,R07381	RC00017,RC00425	ko00000,ko00001,ko01000,ko02042	-	-	-	Phosphoesterase
HKD2_k127_5454161_10	582899.Hden_0007	5.735e-07	60.0	28NY3@1|root,2ZBVC@2|Bacteria,1RCZB@1224|Proteobacteria,2U8YI@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5472302_1	1192034.CAP_5227	1.075e-124	405.0	COG0162@1|root,COG0162@2|Bacteria,1MVUQ@1224|Proteobacteria,42N2A@68525|delta/epsilon subdivisions,2WIP6@28221|Deltaproteobacteria,2YU10@29|Myxococcales	28221|Deltaproteobacteria	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	GO:0003674,GO:0003824,GO:0004812,GO:0004831,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016875,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	S4,tRNA-synt_1b
HKD2_k127_5472302_4	1192034.CAP_5226	1.271e-48	188.0	COG0776@1|root,COG0776@2|Bacteria,1MZ7M@1224|Proteobacteria,42TVD@68525|delta/epsilon subdivisions,2WQPX@28221|Deltaproteobacteria,2Z13W@29|Myxococcales	28221|Deltaproteobacteria	L	Belongs to the bacterial histone-like protein family	ihfB	-	-	ko:K05788	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
HKD2_k127_5472302_0	1254432.SCE1572_03580	1.714e-193	627.0	COG1287@1|root,COG1287@2|Bacteria	2|Bacteria	S	oligosaccharyl transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5472302_3	1192034.CAP_4581	1.814e-114	385.0	COG0810@1|root,COG1629@1|root,COG0810@2|Bacteria,COG4771@2|Bacteria,1R5B9@1224|Proteobacteria,43C1I@68525|delta/epsilon subdivisions,2X7C6@28221|Deltaproteobacteria,2YWPC@29|Myxococcales	28221|Deltaproteobacteria	MP	Periplasmic protein TonB links inner and outer membranes	-	-	-	-	-	-	-	-	-	-	-	-	CarbopepD_reg_2,CarboxypepD_reg,Plug,TonB_C,TonB_dep_Rec
HKD2_k127_5483760_0	483219.LILAB_35185	3.466e-122	412.0	COG2217@1|root,COG2608@1|root,COG2217@2|Bacteria,COG2608@2|Bacteria,1MU08@1224|Proteobacteria,42M2R@68525|delta/epsilon subdivisions,2WJ4J@28221|Deltaproteobacteria,2YX0C@29|Myxococcales	28221|Deltaproteobacteria	P	Heavy-metal-associated domain	-	-	3.6.3.4,3.6.3.54	ko:K01533,ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
HKD2_k127_5490081_0	1192034.CAP_8840	2.997e-122	401.0	COG2844@1|root,COG2844@2|Bacteria,1P77X@1224|Proteobacteria,433GP@68525|delta/epsilon subdivisions,2WXFN@28221|Deltaproteobacteria,2YW9R@29|Myxococcales	28221|Deltaproteobacteria	O	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	2.7.7.19	ko:K00970	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	HD
HKD2_k127_5492885_0	83406.HDN1F_20130	7.837e-51	194.0	COG2730@1|root,COG2730@2|Bacteria,1R5YR@1224|Proteobacteria,1SIZY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Belongs to the glycosyl hydrolase 5 (cellulase A) family	-	-	3.2.1.123	ko:K05991	-	-	-	-	ko00000,ko01000	-	GH5	-	Cellulase
HKD2_k127_5492885_1	1144275.COCOR_03192	3.349e-39	156.0	COG1633@1|root,COG1633@2|Bacteria,1PZ9S@1224|Proteobacteria,435U6@68525|delta/epsilon subdivisions,2X09F@28221|Deltaproteobacteria,2Z1G1@29|Myxococcales	28221|Deltaproteobacteria	S	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5509393_0	1192034.CAP_6409	2.331e-100	342.0	2DYJ3@1|root,34A1W@2|Bacteria,1PDJB@1224|Proteobacteria,435GY@68525|delta/epsilon subdivisions,2X99N@28221|Deltaproteobacteria,2Z2SE@29|Myxococcales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF3570)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3570
HKD2_k127_5509393_1	1254432.SCE1572_48120	2.159e-83	291.0	COG0845@1|root,COG0845@2|Bacteria,1MXGH@1224|Proteobacteria,42M4G@68525|delta/epsilon subdivisions,2WKAK@28221|Deltaproteobacteria,2YUR4@29|Myxococcales	28221|Deltaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
HKD2_k127_5509393_2	215803.DB30_8103	1.366e-65	229.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJ8D@28221|Deltaproteobacteria,2YYD8@29|Myxococcales	28221|Deltaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
HKD2_k127_5514337_1	1192034.CAP_1473	2.662e-73	271.0	COG0657@1|root,COG0657@2|Bacteria,1MVRE@1224|Proteobacteria,42XSE@68525|delta/epsilon subdivisions,2WTGG@28221|Deltaproteobacteria,2YYH0@29|Myxococcales	28221|Deltaproteobacteria	I	Pectinacetylesterase	-	-	-	-	-	-	-	-	-	-	-	-	PAE
HKD2_k127_5514337_2	1348663.KCH_09380	3.513e-68	248.0	COG3831@1|root,COG3831@2|Bacteria,2HIEQ@201174|Actinobacteria,2M4DS@2063|Kitasatospora	201174|Actinobacteria	S	Proposed nucleic acid binding domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4132,WGR
HKD2_k127_5514337_4	1254432.SCE1572_35230	1.041e-41	170.0	COG0566@1|root,COG0566@2|Bacteria	2|Bacteria	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family	trmH	-	2.1.1.185,2.1.1.34	ko:K00556,ko:K03218,ko:K03437	-	-	-	-	ko00000,ko01000,ko03009,ko03016	-	-	-	SpoU_methylase
HKD2_k127_5514337_3	246197.MXAN_6790	4.155e-56	204.0	COG0625@1|root,COG0625@2|Bacteria,1QA0M@1224|Proteobacteria,434R5@68525|delta/epsilon subdivisions,2WZ2A@28221|Deltaproteobacteria,2Z169@29|Myxococcales	28221|Deltaproteobacteria	O	Glutathione S-transferase, N-terminal domain	-	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C_2,GST_N_3
HKD2_k127_5514337_0	448385.sce0838	1.186e-73	249.0	COG0048@1|root,COG0048@2|Bacteria,1RCWY@1224|Proteobacteria,42RDQ@68525|delta/epsilon subdivisions,2WND8@28221|Deltaproteobacteria,2YV8E@29|Myxococcales	28221|Deltaproteobacteria	J	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit	rpsL	-	-	ko:K02950	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosom_S12_S23
HKD2_k127_552439_9	1123270.ATUR01000003_gene1007	6.102e-09	62.0	COG2846@1|root,COG2846@2|Bacteria,1RHZK@1224|Proteobacteria,2UMFF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	D	Hemerythrin HHE cation binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
HKD2_k127_552439_3	290397.Adeh_0078	1.445e-42	164.0	2A9VF@1|root,30Z3B@2|Bacteria,1PKZS@1224|Proteobacteria,435JG@68525|delta/epsilon subdivisions,2WZXJ@28221|Deltaproteobacteria,2Z0YG@29|Myxococcales	290397.Adeh_0078|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_552439_8	118163.Ple7327_3825	1.379e-10	74.0	COG0428@1|root,COG0664@1|root,COG0428@2|Bacteria,COG0664@2|Bacteria,1G2YK@1117|Cyanobacteria,3VN15@52604|Pleurocapsales	1117|Cyanobacteria	PT	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Zip,cNMP_binding
HKD2_k127_552439_10	479432.Sros_1762	4.097e-07	63.0	COG4325@1|root,COG4325@2|Bacteria,2GM70@201174|Actinobacteria,4EH79@85012|Streptosporangiales	201174|Actinobacteria	M	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_552439_1	1192034.CAP_0764	2.603e-114	380.0	COG0667@1|root,COG0667@2|Bacteria,1MVEH@1224|Proteobacteria,42MDR@68525|delta/epsilon subdivisions,2WKUR@28221|Deltaproteobacteria,2YUKZ@29|Myxococcales	28221|Deltaproteobacteria	C	Aldo/keto reductase family	-	-	1.1.1.65	ko:K05275	ko00750,ko01100,ko01120,map00750,map01100,map01120	-	R01708	RC00116	ko00000,ko00001,ko01000	-	-	-	Aldo_ket_red
HKD2_k127_552439_2	502025.Hoch_4959	1.698e-50	197.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,4399Y@68525|delta/epsilon subdivisions,2X4HE@28221|Deltaproteobacteria,2YZ0V@29|Myxococcales	28221|Deltaproteobacteria	KLT	Protein kinase; unclassified specificity.	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HKD2_k127_552439_0	1254432.SCE1572_41035	1.15e-153	505.0	COG2114@1|root,COG2114@2|Bacteria,1MV1V@1224|Proteobacteria,42SUQ@68525|delta/epsilon subdivisions,2WPIY@28221|Deltaproteobacteria,2Z0N9@29|Myxococcales	28221|Deltaproteobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc,HAMP
HKD2_k127_552439_7	1144275.COCOR_05734	1.712e-19	99.0	COG2010@1|root,COG2010@2|Bacteria,1PD95@1224|Proteobacteria,43E5K@68525|delta/epsilon subdivisions,2WZSQ@28221|Deltaproteobacteria,2Z2P1@29|Myxococcales	28221|Deltaproteobacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_552439_6	485913.Krac_2885	1.211e-22	115.0	COG2355@1|root,COG2355@2|Bacteria	2|Bacteria	E	Zn-dependent dipeptidase, microsomal dipeptidase	-	-	3.4.13.19	ko:K01273	-	-	-	-	ko00000,ko00537,ko01000,ko01002,ko04147	-	-	-	Peptidase_M19
HKD2_k127_552439_5	1254432.SCE1572_04385	1.906e-24	117.0	COG2885@1|root,COG2885@2|Bacteria,1QAG8@1224|Proteobacteria,4352E@68525|delta/epsilon subdivisions,2WZDB@28221|Deltaproteobacteria,2Z1W3@29|Myxococcales	28221|Deltaproteobacteria	M	Belongs to the ompA family	-	-	-	ko:K03640	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	OmpA
HKD2_k127_5528957_5	684949.ATTJ01000003_gene3320	4.613e-16	81.0	COG1846@1|root,COG1846@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
HKD2_k127_5528957_0	448385.sce7927	2.052e-308	957.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,42MHP@68525|delta/epsilon subdivisions,2WIQG@28221|Deltaproteobacteria,2YUFQ@29|Myxococcales	28221|Deltaproteobacteria	H	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	acsA	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
HKD2_k127_5528957_3	1144275.COCOR_01170	2.262e-29	134.0	COG0683@1|root,COG0683@2|Bacteria,1MWJ1@1224|Proteobacteria,42UMR@68525|delta/epsilon subdivisions,2WQ71@28221|Deltaproteobacteria,2YVN1@29|Myxococcales	28221|Deltaproteobacteria	E	Periplasmic binding protein	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
HKD2_k127_5528957_1	1192034.CAP_3350	8.818e-87	319.0	COG0683@1|root,COG0683@2|Bacteria,1MWJ1@1224|Proteobacteria,42UMR@68525|delta/epsilon subdivisions,2WQ71@28221|Deltaproteobacteria,2YVN1@29|Myxococcales	28221|Deltaproteobacteria	E	Periplasmic binding protein	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
HKD2_k127_5528957_2	1121481.AUAS01000006_gene877	1.565e-68	255.0	COG1520@1|root,COG2931@1|root,COG5184@1|root,COG1520@2|Bacteria,COG2931@2|Bacteria,COG5184@2|Bacteria,4NKIR@976|Bacteroidetes,47S7V@768503|Cytophagia	976|Bacteroidetes	Q	SMART Integrin alpha beta-propellor repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,FG-GAP,HYR,VCBS
HKD2_k127_5528957_4	869210.Marky_1921	9.302e-26	114.0	COG0517@1|root,COG5485@1|root,COG0517@2|Bacteria,COG5485@2|Bacteria,1WK3F@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
HKD2_k127_5530503_1	1192034.CAP_1783	7.481e-26	113.0	COG1674@1|root,COG1674@2|Bacteria,1MVPI@1224|Proteobacteria,42N4X@68525|delta/epsilon subdivisions,2WIPR@28221|Deltaproteobacteria,2YU2E@29|Myxococcales	28221|Deltaproteobacteria	D	Belongs to the FtsK SpoIIIE SftA family	ftsK	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
HKD2_k127_5530503_0	448385.sce7983	4.648e-96	329.0	COG1413@1|root,COG1413@2|Bacteria	2|Bacteria	C	deoxyhypusine monooxygenase activity	-	-	2.4.1.227,2.7.11.1,3.4.11.2	ko:K01256,ko:K02563,ko:K08776,ko:K12132	ko00480,ko00550,ko01100,ko01502,ko04112,map00480,map00550,map01100,map01502,map04112	-	R00899,R04951,R05032,R05662	RC00005,RC00049,RC00096,RC00141	ko00000,ko00001,ko01000,ko01001,ko01002,ko01011	-	GT28	-	HEAT_2,Peptidase_M1,Sulfatase,T2SSE_N
HKD2_k127_5531568_1	1254432.SCE1572_35180	4.042e-201	640.0	COG2304@1|root,COG2304@2|Bacteria,1PYZT@1224|Proteobacteria,435MP@68525|delta/epsilon subdivisions,2XA2Q@28221|Deltaproteobacteria,2YYF8@29|Myxococcales	28221|Deltaproteobacteria	S	Aerotolerance regulator N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	BatA,VWA_2
HKD2_k127_5531568_0	1254432.SCE1572_35175	4.696e-215	685.0	COG2304@1|root,COG2304@2|Bacteria,1N4IM@1224|Proteobacteria,437ZC@68525|delta/epsilon subdivisions,2WZWU@28221|Deltaproteobacteria,2YUXT@29|Myxococcales	28221|Deltaproteobacteria	S	von Willebrand factor type A domain	-	-	-	-	-	-	-	-	-	-	-	-	GATase1_like,VWA
HKD2_k127_5538013_2	196162.Noca_2810	0.0002238	52.0	COG0500@1|root,COG2226@2|Bacteria,2IHPD@201174|Actinobacteria,4DWVV@85009|Propionibacteriales	201174|Actinobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_12,Methyltransf_23,Methyltransf_25
HKD2_k127_5538013_1	483219.LILAB_15775	3.888e-06	61.0	2AJ97@1|root,319U5@2|Bacteria,1Q3ZT@1224|Proteobacteria,4344H@68525|delta/epsilon subdivisions,2X56Y@28221|Deltaproteobacteria,2Z078@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5538013_0	448385.sce0371	8.928e-61	218.0	COG1704@1|root,COG1704@2|Bacteria,1MVH0@1224|Proteobacteria,42R4C@68525|delta/epsilon subdivisions,2WKG9@28221|Deltaproteobacteria,2Z24Q@29|Myxococcales	28221|Deltaproteobacteria	S	LemA family	-	-	-	ko:K03744	-	-	-	-	ko00000	-	-	-	LemA
HKD2_k127_5540464_1	1242864.D187_010262	3.839e-32	126.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD2_k127_5540464_2	378806.STAUR_2287	1.107e-21	106.0	2B71D@1|root,32020@2|Bacteria,1QKP4@1224|Proteobacteria,434WF@68525|delta/epsilon subdivisions,2WZ7F@28221|Deltaproteobacteria,2Z1HR@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5540464_0	1254432.SCE1572_21240	2.893e-37	145.0	COG0266@1|root,COG0266@2|Bacteria,1N1J5@1224|Proteobacteria,433TA@68525|delta/epsilon subdivisions,2X3D6@28221|Deltaproteobacteria,2YVHV@29|Myxococcales	28221|Deltaproteobacteria	L	Belongs to the FPG family	-	-	4.2.99.18	ko:K05522	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
HKD2_k127_5551765_0	1192034.CAP_4581	1.113e-115	382.0	COG0810@1|root,COG1629@1|root,COG0810@2|Bacteria,COG4771@2|Bacteria,1R5B9@1224|Proteobacteria,43C1I@68525|delta/epsilon subdivisions,2X7C6@28221|Deltaproteobacteria,2YWPC@29|Myxococcales	28221|Deltaproteobacteria	MP	Periplasmic protein TonB links inner and outer membranes	-	-	-	-	-	-	-	-	-	-	-	-	CarbopepD_reg_2,CarboxypepD_reg,Plug,TonB_C,TonB_dep_Rec
HKD2_k127_5551765_4	1242864.D187_001421	4.636e-15	86.0	COG5479@1|root,COG5479@2|Bacteria	2|Bacteria	M	isomerase activity	-	-	-	-	-	-	-	-	-	-	-	-	Cellulase,DNase_NucA_NucB,LGFP,YkuD
HKD2_k127_5551765_2	448385.sce2883	1.762e-50	194.0	COG3930@1|root,COG3930@2|Bacteria	2|Bacteria	E	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF1704
HKD2_k127_5551765_1	1192034.CAP_4589	7.349e-59	219.0	COG1875@1|root,COG1875@2|Bacteria,1MUX1@1224|Proteobacteria,42MK9@68525|delta/epsilon subdivisions,2WJ1C@28221|Deltaproteobacteria,2YY78@29|Myxococcales	28221|Deltaproteobacteria	T	Large family of predicted nucleotide-binding domains	phoH1	-	-	ko:K07175	-	-	-	-	ko00000	-	-	-	PIN_4,PhoH
HKD2_k127_5559224_2	1192034.CAP_1198	4.993e-06	57.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5559224_1	448385.sce3023	1.07e-07	61.0	2BQRM@1|root,32JN9@2|Bacteria,1PDHV@1224|Proteobacteria,435GS@68525|delta/epsilon subdivisions,2WZUA@28221|Deltaproteobacteria,2Z2RV@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5559224_0	1254432.SCE1572_35935	4.057e-58	215.0	COG2706@1|root,COG2706@2|Bacteria,1MUKZ@1224|Proteobacteria,4394D@68525|delta/epsilon subdivisions,2X4AE@28221|Deltaproteobacteria,2YYM5@29|Myxococcales	28221|Deltaproteobacteria	G	Lactonase, 7-bladed beta-propeller	-	-	3.1.1.31	ko:K07404	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200	M00004,M00006,M00008	R02035	RC00537	ko00000,ko00001,ko00002,ko01000	-	-	-	Lactonase
HKD2_k127_5559224_3	1298863.AUEP01000006_gene3326	9.638e-06	51.0	COG3631@1|root,COG3631@2|Bacteria,2IP61@201174|Actinobacteria	201174|Actinobacteria	S	SnoaL-like polyketide cyclase	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_2
HKD2_k127_5561760_0	330214.NIDE0795	4.515e-99	333.0	COG0332@1|root,COG0332@2|Bacteria,3J0FW@40117|Nitrospirae	40117|Nitrospirae	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	fabH	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
HKD2_k127_5561760_3	448385.sce3818	1.682e-18	86.0	COG0333@1|root,COG0333@2|Bacteria,1NGM1@1224|Proteobacteria,42VTE@68525|delta/epsilon subdivisions,2WRXV@28221|Deltaproteobacteria,2Z1YD@29|Myxococcales	28221|Deltaproteobacteria	J	Ribosomal L32p protein family	rpmF	-	-	ko:K02911	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_L32p
HKD2_k127_5561760_2	1254432.SCE1572_22945	4.477e-25	118.0	COG1399@1|root,COG1399@2|Bacteria,1N7GQ@1224|Proteobacteria,42U2P@68525|delta/epsilon subdivisions,2WRMV@28221|Deltaproteobacteria,2YW6X@29|Myxococcales	28221|Deltaproteobacteria	S	Uncharacterized ACR, COG1399	-	-	-	ko:K07040	-	-	-	-	ko00000	-	-	-	DUF177
HKD2_k127_5561760_1	448385.sce8814	5.636e-48	177.0	COG1858@1|root,COG3391@1|root,COG1858@2|Bacteria,COG3391@2|Bacteria,1R7E0@1224|Proteobacteria,42XD8@68525|delta/epsilon subdivisions,2WT8U@28221|Deltaproteobacteria,2YV4I@29|Myxococcales	28221|Deltaproteobacteria	C	TIGRFAM 40-residue YVTN family beta-propeller repeat	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,Cytochrome_C7
HKD2_k127_5580439_0	448385.sce4325	4.769e-86	292.0	COG0652@1|root,COG0652@2|Bacteria,1RENS@1224|Proteobacteria,42RIB@68525|delta/epsilon subdivisions,2WINS@28221|Deltaproteobacteria,2YV44@29|Myxococcales	28221|Deltaproteobacteria	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	-	-	5.2.1.8	ko:K03767	ko01503,ko04217,map01503,map04217	-	-	-	ko00000,ko00001,ko01000,ko03110,ko04147	-	-	-	Pro_isomerase
HKD2_k127_5580439_1	1254432.SCE1572_26115	5.891e-44	163.0	COG1430@1|root,COG1430@2|Bacteria,1MZBJ@1224|Proteobacteria,42VH9@68525|delta/epsilon subdivisions,2WT3R@28221|Deltaproteobacteria,2YVNR@29|Myxococcales	28221|Deltaproteobacteria	S	Uncharacterized ACR, COG1430	-	-	-	ko:K09005	-	-	-	-	ko00000	-	-	-	DUF192
HKD2_k127_5583591_6	1192034.CAP_8888	3.386e-16	93.0	COG1009@1|root,COG1009@2|Bacteria	2|Bacteria	CP	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit	-	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M,Proton_antipo_N
HKD2_k127_5583591_4	1298863.AUEP01000004_gene2295	2.665e-35	157.0	COG1008@1|root,COG1008@2|Bacteria,2GKBN@201174|Actinobacteria,4DPXE@85009|Propionibacteriales	201174|Actinobacteria	C	Proton-conducting membrane transporter	nuoM	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
HKD2_k127_5583591_2	1278073.MYSTI_06626	1.484e-91	308.0	COG3694@1|root,COG3694@2|Bacteria,1NAPK@1224|Proteobacteria,42X7R@68525|delta/epsilon subdivisions,2WSZA@28221|Deltaproteobacteria,2YVA3@29|Myxococcales	28221|Deltaproteobacteria	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_6
HKD2_k127_5583591_1	378806.STAUR_6671	1.392e-94	325.0	COG4587@1|root,COG4587@2|Bacteria,1NBY6@1224|Proteobacteria,42XYD@68525|delta/epsilon subdivisions,2WY0V@28221|Deltaproteobacteria,2YVAD@29|Myxococcales	28221|Deltaproteobacteria	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_6
HKD2_k127_5583591_0	290397.Adeh_0404	8.157e-127	413.0	COG4586@1|root,COG4586@2|Bacteria,1RA7G@1224|Proteobacteria,42RT3@68525|delta/epsilon subdivisions,2WNGM@28221|Deltaproteobacteria,2YU3C@29|Myxococcales	28221|Deltaproteobacteria	S	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD2_k127_5583591_7	164757.Mjls_2617	1.842e-05	54.0	COG1846@1|root,COG1846@2|Bacteria,2IMA9@201174|Actinobacteria,238RY@1762|Mycobacteriaceae	201174|Actinobacteria	K	Transcriptional regulator	ohrR	-	-	-	-	-	-	-	-	-	-	-	MarR
HKD2_k127_5583591_3	448385.sce9360	7.098e-89	302.0	COG0224@1|root,COG0224@2|Bacteria,1MU28@1224|Proteobacteria,42N8B@68525|delta/epsilon subdivisions,2WJ6I@28221|Deltaproteobacteria,2YUV1@29|Myxococcales	28221|Deltaproteobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex	atpG	-	-	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt
HKD2_k127_5583591_5	1254432.SCE1572_52685	7.26e-31	125.0	COG0056@1|root,COG0056@2|Bacteria,1MUG7@1224|Proteobacteria,42MVX@68525|delta/epsilon subdivisions,2WIK7@28221|Deltaproteobacteria,2YUF7@29|Myxococcales	28221|Deltaproteobacteria	F	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	atpA	-	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
HKD2_k127_5594212_1	1121920.AUAU01000016_gene1289	1.094e-131	425.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria	2|Bacteria	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR,POR_N,Transketolase_C
HKD2_k127_5594212_3	693986.MOC_4370	2.518e-102	353.0	COG1032@1|root,COG1032@2|Bacteria,1MY2Y@1224|Proteobacteria,2TUIT@28211|Alphaproteobacteria,1JUFV@119045|Methylobacteriaceae	28211|Alphaproteobacteria	C	Domain of unknown function (DUF4070)	MA20_17485	-	-	-	-	-	-	-	-	-	-	-	B12-binding,DUF4070,Radical_SAM
HKD2_k127_5594212_5	83406.HDN1F_14490	7.984e-59	227.0	COG4689@1|root,COG4689@2|Bacteria,1R7YD@1224|Proteobacteria,1S1RP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	Acetoacetate decarboxylase (ADC)	-	-	-	-	-	-	-	-	-	-	-	-	ADC
HKD2_k127_5594212_0	1415780.JPOG01000001_gene964	3.213e-144	471.0	COG1960@1|root,COG1960@2|Bacteria,1R5M1@1224|Proteobacteria,1SKHT@1236|Gammaproteobacteria,1X9EP@135614|Xanthomonadales	135614|Xanthomonadales	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HKD2_k127_5594212_6	1415780.JPOG01000001_gene963	6.357e-50	195.0	COG1960@1|root,COG1960@2|Bacteria,1NC6Q@1224|Proteobacteria,1SQTG@1236|Gammaproteobacteria,1XASC@135614|Xanthomonadales	135614|Xanthomonadales	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1
HKD2_k127_5594212_7	85643.Tmz1t_2945	9.607e-34	139.0	COG0454@1|root,COG0456@2|Bacteria,1RGZ2@1224|Proteobacteria,2VXB4@28216|Betaproteobacteria,2KXES@206389|Rhodocyclales	206389|Rhodocyclales	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HKD2_k127_5594212_4	1232410.KI421421_gene3273	8.379e-78	286.0	COG1924@1|root,COG1924@2|Bacteria,1R6HU@1224|Proteobacteria,42PM0@68525|delta/epsilon subdivisions,2X5NK@28221|Deltaproteobacteria,43W2S@69541|Desulfuromonadales	68525|delta/epsilon subdivisions	I	BadF/BadG/BcrA/BcrD ATPase family	hgdC	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG
HKD2_k127_5594212_2	1232410.KI421421_gene3272	5.798e-118	392.0	COG1924@1|root,COG1924@2|Bacteria,1R6HU@1224|Proteobacteria,42PM0@68525|delta/epsilon subdivisions,2X5NK@28221|Deltaproteobacteria,43W2S@69541|Desulfuromonadales	28221|Deltaproteobacteria	I	BadF/BadG/BcrA/BcrD ATPase family	-	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG
HKD2_k127_560137_1	448385.sce1028	2.707e-129	421.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	gt4G	-	2.7.1.33	ko:K03525	ko00770,ko01100,map00770,map01100	M00120	R02971,R03018,R04391	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
HKD2_k127_560137_3	794903.OPIT5_11640	2.836e-67	241.0	COG0451@1|root,COG0451@2|Bacteria,46SJG@74201|Verrucomicrobia,3K7RE@414999|Opitutae	414999|Opitutae	M	PFAM NAD-dependent epimerase dehydratase	-	-	5.1.3.6	ko:K08679	ko00520,ko01100,map00520,map01100	-	R01385	RC00289	ko00000,ko00001,ko01000	-	-	-	Epimerase
HKD2_k127_560137_2	1159870.KB907784_gene1397	1.988e-122	406.0	COG1004@1|root,COG1004@2|Bacteria,1MW5U@1224|Proteobacteria,2VGZI@28216|Betaproteobacteria,3T369@506|Alcaligenaceae	28216|Betaproteobacteria	M	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	ugd	-	1.1.1.22	ko:K00012	ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100	M00014,M00129,M00361,M00362	R00286	RC00291	ko00000,ko00001,ko00002,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
HKD2_k127_560137_7	396595.TK90_2516	8.426e-28	128.0	COG2230@1|root,COG2230@2|Bacteria,1NKE6@1224|Proteobacteria,1T4CW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23
HKD2_k127_560137_8	32057.KB217478_gene1436	7.025e-20	100.0	COG1216@1|root,COG1216@2|Bacteria,1G09N@1117|Cyanobacteria,1HSNK@1161|Nostocales	1117|Cyanobacteria	S	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HKD2_k127_560137_6	1049564.TevJSym_at00200	1.492e-28	129.0	COG0438@1|root,COG0438@2|Bacteria,1MU9C@1224|Proteobacteria,1RS5D@1236|Gammaproteobacteria,1J70I@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
HKD2_k127_560137_9	926690.KE386573_gene826	6.137e-18	99.0	COG2244@1|root,arCOG02209@2157|Archaea,2XUGQ@28890|Euryarchaeota,23SS6@183963|Halobacteria	183963|Halobacteria	S	Membrane protein involved in the export of O-antigen and teichoic acid	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt,Polysacc_synt_C
HKD2_k127_560137_4	760568.Desku_1744	1.032e-30	136.0	COG0438@1|root,COG0438@2|Bacteria,1TRCM@1239|Firmicutes,25BWB@186801|Clostridia	186801|Clostridia	M	Glycosyl transferase 4-like	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_1
HKD2_k127_560137_0	886293.Sinac_0268	3.127e-139	465.0	COG0367@1|root,COG0367@2|Bacteria,2IXAI@203682|Planctomycetes	203682|Planctomycetes	E	Asparagine synthase, glutamine-hydrolyzing	-	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
HKD2_k127_560137_5	448385.sce6014	5.132e-29	127.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2YTW0@29|Myxococcales	28221|Deltaproteobacteria	T	response regulator	-	-	-	ko:K02481,ko:K07713	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD2_k127_5616378_1	706587.Desti_0626	5.641e-182	576.0	COG2407@1|root,COG2407@2|Bacteria,1NTJI@1224|Proteobacteria	1224|Proteobacteria	G	Converts the aldose L-fucose into the corresponding ketose L-fuculose	-	-	-	-	-	-	-	-	-	-	-	-	Fucose_iso_C
HKD2_k127_5616378_6	1123256.KB907929_gene3255	8.66e-107	350.0	COG0235@1|root,COG0235@2|Bacteria,1MWP9@1224|Proteobacteria,1RQNI@1236|Gammaproteobacteria,1X51V@135614|Xanthomonadales	135614|Xanthomonadales	G	Class II Aldolase and Adducin N-terminal domain	-	-	4.1.2.17	ko:K01628	ko00051,ko01120,map00051,map01120	-	R02262	RC00603,RC00604	ko00000,ko00001,ko01000	-	-	-	Aldolase_II
HKD2_k127_5616378_0	794903.OPIT5_25990	3.479e-197	637.0	COG1069@1|root,COG1069@2|Bacteria,46YWR@74201|Verrucomicrobia,3K95Q@414999|Opitutae	414999|Opitutae	C	FGGY family of carbohydrate kinases, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	FGGY_C,FGGY_N
HKD2_k127_5616378_2	1121939.L861_00430	1.248e-180	578.0	COG0277@1|root,COG0277@2|Bacteria,1MUPW@1224|Proteobacteria,1RRDD@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	FAD linked oxidase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	BBE,FAD_binding_4
HKD2_k127_5616378_3	1192034.CAP_2649	4.5e-150	480.0	COG2355@1|root,COG2355@2|Bacteria,1MWEW@1224|Proteobacteria,42NXB@68525|delta/epsilon subdivisions,2WMBF@28221|Deltaproteobacteria,2YV6N@29|Myxococcales	28221|Deltaproteobacteria	E	Membrane dipeptidase (Peptidase family M19)	-	-	3.4.13.19	ko:K01273	-	-	-	-	ko00000,ko00537,ko01000,ko01002,ko04147	-	-	-	Peptidase_M19
HKD2_k127_5616378_5	1192034.CAP_4129	2.473e-127	413.0	COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,42N1R@68525|delta/epsilon subdivisions,2WJ7R@28221|Deltaproteobacteria,2YWJD@29|Myxococcales	28221|Deltaproteobacteria	E	Belongs to the cysteine synthase cystathionine beta- synthase family	cysK-1	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HKD2_k127_5616378_8	448385.sce5756	6.93e-64	228.0	COG0476@1|root,COG0476@2|Bacteria,1MW7H@1224|Proteobacteria,42NEC@68525|delta/epsilon subdivisions,2WK08@28221|Deltaproteobacteria,2YUA5@29|Myxococcales	28221|Deltaproteobacteria	HP	domain protein	-	-	2.7.7.80	ko:K21029	ko04122,map04122	-	R07459	RC00043	ko00000,ko00001,ko01000	-	-	-	ThiF
HKD2_k127_5616378_13	1254432.SCE1572_34190	7.561e-39	146.0	COG1977@1|root,COG1977@2|Bacteria,1N15U@1224|Proteobacteria,42XSH@68525|delta/epsilon subdivisions,2WTDG@28221|Deltaproteobacteria,2Z1PX@29|Myxococcales	28221|Deltaproteobacteria	H	ThiS family	-	-	-	ko:K03636	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
HKD2_k127_5616378_4	448385.sce5753	3.511e-139	449.0	COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,42M6M@68525|delta/epsilon subdivisions,2WIQM@28221|Deltaproteobacteria,2YU2W@29|Myxococcales	28221|Deltaproteobacteria	E	PFAM Pyridoxal-5'-phosphate-dependent protein beta subunit	cysM	-	2.5.1.47,6.1.1.16	ko:K01738,ko:K01883,ko:K12339	ko00270,ko00920,ko00970,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map00970,map01100,map01110,map01120,map01130,map01200,map01230	M00021,M00359,M00360	R00897,R03132,R03601,R03650,R04859	RC00020,RC00055,RC00523,RC02814,RC02821,RC02876	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,PALP,tRNA-synt_1e
HKD2_k127_5616378_11	1254432.SCE1572_34175	2.735e-46	172.0	COG1310@1|root,COG1310@2|Bacteria	2|Bacteria	S	proteolysis	-	-	2.7.7.80,2.8.1.11,3.13.1.6	ko:K21140,ko:K21147	ko04122,map04122	-	R07459,R07461,R11524	RC00043,RC00064,RC00090	ko00000,ko00001,ko01000	-	-	-	Prok-JAB,Rhodanese,ThiF
HKD2_k127_5616378_9	1254432.SCE1572_21625	5.174e-60	219.0	COG2822@1|root,COG2822@2|Bacteria	2|Bacteria	P	iron ion transport	efeO	-	-	ko:K07224	-	-	-	-	ko00000,ko02000	2.A.108.2.3	-	-	Cupredoxin_1,Peptidase_M75
HKD2_k127_5617105_1	1410620.SHLA_27c000870	1.299e-27	117.0	COG1959@1|root,COG1959@2|Bacteria,1N05H@1224|Proteobacteria,2UBZM@28211|Alphaproteobacteria,4BF48@82115|Rhizobiaceae	28211|Alphaproteobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Rrf2
HKD2_k127_5617105_0	1547437.LL06_03315	1.651e-176	574.0	COG0003@1|root,COG0003@2|Bacteria,1MUTX@1224|Proteobacteria,2TUA8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Anion-transporting ATPase	arsA	-	3.6.3.16	ko:K01551	-	-	-	-	ko00000,ko01000,ko02000	3.A.19.1,3.A.21.1,3.A.4.1	-	-	ArsA_ATPase,CbiA
HKD2_k127_5617105_2	663610.JQKO01000002_gene1239	5.684e-05	46.0	COG0003@1|root,COG0003@2|Bacteria,1MUTX@1224|Proteobacteria,2TUA8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Anion-transporting ATPase	arsA	-	3.6.3.16	ko:K01551	-	-	-	-	ko00000,ko01000,ko02000	3.A.19.1,3.A.21.1,3.A.4.1	-	-	ArsA_ATPase,CbiA
HKD2_k127_5621399_1	448385.sce5472	1.767e-112	368.0	COG1842@1|root,COG1842@2|Bacteria,1NC7S@1224|Proteobacteria,42VIT@68525|delta/epsilon subdivisions,2WS62@28221|Deltaproteobacteria,2YZJ3@29|Myxococcales	28221|Deltaproteobacteria	KT	PspA/IM30 family	-	-	-	ko:K03969	-	-	-	-	ko00000	-	-	-	PspA_IM30
HKD2_k127_5621399_0	448385.sce5473	0.0	1043.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,42M8F@68525|delta/epsilon subdivisions,2WIU0@28221|Deltaproteobacteria,2YUAS@29|Myxococcales	28221|Deltaproteobacteria	P	TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
HKD2_k127_5621399_2	369723.Strop_2883	2.295e-26	119.0	COG3831@1|root,COG3831@2|Bacteria,2HIEQ@201174|Actinobacteria,4D9WJ@85008|Micromonosporales	201174|Actinobacteria	S	Domain of unknown function (DUF4132)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4132,WGR
HKD2_k127_5629899_2	985665.HPL003_00695	1.194e-45	172.0	COG0624@1|root,COG0624@2|Bacteria,1TP2D@1239|Firmicutes,4HB9G@91061|Bacilli,26SYE@186822|Paenibacillaceae	91061|Bacilli	E	peptidase M20	dapE	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
HKD2_k127_5629899_0	1254432.SCE1572_02430	4.91e-62	226.0	COG0632@1|root,COG0632@2|Bacteria,1MWJR@1224|Proteobacteria,42RPS@68525|delta/epsilon subdivisions,2WPH5@28221|Deltaproteobacteria,2Z0ZS@29|Myxococcales	28221|Deltaproteobacteria	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB	ruvA	-	3.6.4.12	ko:K03550	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HHH_5,RuvA_C,RuvA_N
HKD2_k127_5629899_5	448385.sce1771	5.496e-10	68.0	COG3055@1|root,COG3055@2|Bacteria	2|Bacteria	G	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses	-	-	-	-	-	-	-	-	-	-	-	-	He_PIG,Malectin
HKD2_k127_5629899_3	391625.PPSIR1_06738	1.102e-36	151.0	COG1262@1|root,COG1262@2|Bacteria	391625.PPSIR1_06738|-	T	PFAM Formylglycine-generating sulfatase enzyme	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5629899_1	35128.Thaps3936	1.422e-58	220.0	2CPQW@1|root,2R2E8@2759|Eukaryota,2XESG@2836|Bacillariophyta	2836|Bacillariophyta	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5629899_6	861299.J421_4068	3.737e-06	59.0	COG0515@1|root,COG0515@2|Bacteria,1ZTGA@142182|Gemmatimonadetes	142182|Gemmatimonadetes	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HKD2_k127_5629899_8	1192034.CAP_4085	2.222e-05	56.0	COG4105@1|root,COG4105@2|Bacteria	2|Bacteria	S	cell envelope organization	bamD	-	-	ko:K05807,ko:K08309	-	-	-	-	ko00000,ko01000,ko01011,ko02000	1.B.33.1	GH23	-	YfiO
HKD2_k127_5629899_7	653045.Strvi_6082	9.582e-06	58.0	COG2319@1|root,COG2319@2|Bacteria,2GJN3@201174|Actinobacteria	201174|Actinobacteria	F	WD-40 repeat	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,PD40,TIR_2,WD40
HKD2_k127_5631101_13	1279019.ARQK01000037_gene1677	8.968e-05	55.0	COG0500@1|root,COG2226@2|Bacteria,1MYPU@1224|Proteobacteria,1SZ13@1236|Gammaproteobacteria,1X22Q@135613|Chromatiales	135613|Chromatiales	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
HKD2_k127_5631101_1	1192034.CAP_0066	7.428e-147	479.0	COG3572@1|root,COG3572@2|Bacteria,1MU47@1224|Proteobacteria,42QDI@68525|delta/epsilon subdivisions,2WJMG@28221|Deltaproteobacteria,2YWDT@29|Myxococcales	28221|Deltaproteobacteria	H	glutamate--cysteine ligase	gshA	-	6.3.2.2	ko:K01919	ko00270,ko00480,ko01100,map00270,map00480,map01100	M00118	R00894,R10993	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	GCS2
HKD2_k127_5631101_9	1232410.KI421415_gene3076	2.065e-39	158.0	COG0135@1|root,COG0135@2|Bacteria,1RA87@1224|Proteobacteria,42QQ3@68525|delta/epsilon subdivisions,2WNPH@28221|Deltaproteobacteria,43U0C@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Belongs to the TrpF family	trpF	-	5.3.1.24	ko:K01817	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03509	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	PRAI
HKD2_k127_5631101_6	1254432.SCE1572_10985	3.84e-61	227.0	COG0745@1|root,COG0745@2|Bacteria,1RDNP@1224|Proteobacteria,42RF8@68525|delta/epsilon subdivisions,2WNSP@28221|Deltaproteobacteria,2YVG6@29|Myxococcales	28221|Deltaproteobacteria	T	Chemotaxis protein CheY	cheY	-	-	ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	Response_reg
HKD2_k127_5631101_8	448385.sce1762	4.146e-50	194.0	COG2203@1|root,COG2203@2|Bacteria,1P3F7@1224|Proteobacteria,4318K@68525|delta/epsilon subdivisions,2WWQB@28221|Deltaproteobacteria,2Z23F@29|Myxococcales	28221|Deltaproteobacteria	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	-	-	-	-	-	-	-	-	-	-	GAF_3
HKD2_k127_5631101_3	1254432.SCE1572_10975	1.158e-117	388.0	COG1304@1|root,COG1304@2|Bacteria,1N6KI@1224|Proteobacteria,42TUC@68525|delta/epsilon subdivisions,2WQGC@28221|Deltaproteobacteria,2YUIJ@29|Myxococcales	28221|Deltaproteobacteria	C	Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP)	fni	-	5.3.3.2	ko:K01823	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00095,M00096,M00364,M00365,M00366,M00367	R01123	RC00455	ko00000,ko00001,ko00002,ko01000	-	-	-	FMN_dh
HKD2_k127_5631101_7	1254432.SCE1572_25530	3.49e-59	218.0	COG0142@1|root,COG0142@2|Bacteria,1PIT3@1224|Proteobacteria,4354P@68525|delta/epsilon subdivisions,2X95E@28221|Deltaproteobacteria,2Z21G@29|Myxococcales	28221|Deltaproteobacteria	H	Polyprenyl synthetase	-	-	2.5.1.1,2.5.1.10,2.5.1.29	ko:K13787	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00365	R01658,R02003,R02061	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
HKD2_k127_5631101_5	448385.sce4205	1.222e-67	246.0	COG1577@1|root,COG1577@2|Bacteria,1NBQM@1224|Proteobacteria,43C2T@68525|delta/epsilon subdivisions,2X7DD@28221|Deltaproteobacteria,2YVJ4@29|Myxococcales	28221|Deltaproteobacteria	I	mevalonate kinase	mvk	-	2.7.1.36	ko:K00869	ko00900,ko01100,ko01110,ko01130,ko04146,map00900,map01100,map01110,map01130,map04146	M00095	R02245	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
HKD2_k127_5631101_4	1254432.SCE1572_25540	8.076e-80	284.0	COG3407@1|root,COG3407@2|Bacteria,1N5EZ@1224|Proteobacteria,4322G@68525|delta/epsilon subdivisions,2WWNM@28221|Deltaproteobacteria,2YUWJ@29|Myxococcales	28221|Deltaproteobacteria	I	GHMP kinases N terminal domain	mvaD	-	4.1.1.33	ko:K01597	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00095	R01121	RC00453	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_N
HKD2_k127_5631101_11	666685.R2APBS1_3946	9.167e-21	108.0	COG1577@1|root,COG1577@2|Bacteria,1N400@1224|Proteobacteria,1SC29@1236|Gammaproteobacteria,1XAB2@135614|Xanthomonadales	135614|Xanthomonadales	I	GHMP kinases N terminal domain	-	-	2.7.4.2	ko:K00938	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00095	R03245	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_N
HKD2_k127_5631101_2	1521187.JPIM01000118_gene809	1.142e-135	447.0	COG1257@1|root,COG1257@2|Bacteria,2G5QV@200795|Chloroflexi,375AX@32061|Chloroflexia	32061|Chloroflexia	C	Belongs to the HMG-CoA reductase family	-	-	1.1.1.88	ko:K00054	ko00900,ko01110,ko01130,map00900,map01110,map01130	-	R02081	RC00004,RC00644	ko00000,ko00001,ko01000	-	-	-	HMG-CoA_red
HKD2_k127_5631101_12	1121381.JNIV01000045_gene877	5.895e-07	58.0	2AVUP@1|root,31MND@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	NfeD
HKD2_k127_5631101_0	1192034.CAP_7998	1.863e-147	479.0	COG2268@1|root,COG2268@2|Bacteria,1QIR4@1224|Proteobacteria,42Q0N@68525|delta/epsilon subdivisions,2WJDJ@28221|Deltaproteobacteria,2YX63@29|Myxococcales	28221|Deltaproteobacteria	S	prohibitin homologues	-	-	-	ko:K07192	ko04910,map04910	-	-	-	ko00000,ko00001,ko03036,ko04131,ko04147	-	-	-	Band_7,Flot
HKD2_k127_5631101_10	391625.PPSIR1_12953	5.892e-22	111.0	COG2268@1|root,COG2268@2|Bacteria,1QIR4@1224|Proteobacteria,42Q0N@68525|delta/epsilon subdivisions,2WJDJ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Band 7 protein	-	-	-	ko:K07192	ko04910,map04910	-	-	-	ko00000,ko00001,ko03036,ko04131,ko04147	-	-	-	Band_7,Flot
HKD2_k127_5634247_0	1254432.SCE1572_02165	0.0	1733.0	COG0457@1|root,COG2956@1|root,COG3118@1|root,COG0457@2|Bacteria,COG2956@2|Bacteria,COG3118@2|Bacteria,1MVIW@1224|Proteobacteria,4391J@68525|delta/epsilon subdivisions,2X472@28221|Deltaproteobacteria,2YYDY@29|Myxococcales	28221|Deltaproteobacteria	GO	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_19,TPR_6,TPR_7,TPR_8
HKD2_k127_5637710_2	1254432.SCE1572_15465	1.348e-43	179.0	COG2018@1|root,COG2018@2|Bacteria	2|Bacteria	K	Roadblock/LC7 domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4388,Robl_LC7
HKD2_k127_5637710_3	1254432.SCE1572_15460	2.632e-28	132.0	COG0760@1|root,COG0760@2|Bacteria	2|Bacteria	O	peptidyl-prolyl cis-trans isomerase activity	nifM	-	2.3.1.39,5.2.1.8	ko:K00645,ko:K02597,ko:K03769,ko:K03771	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	M00082	R01626,R11671	RC00004,RC00039,RC02727	ko00000,ko00001,ko00002,ko01000,ko01004,ko03110	-	-	-	Rotamase,Rotamase_2,Rotamase_3,SurA_N_3
HKD2_k127_5637710_0	1254432.SCE1572_15445	1.704e-110	364.0	COG0037@1|root,COG0037@2|Bacteria,1MW5Q@1224|Proteobacteria,42MMC@68525|delta/epsilon subdivisions,2WN12@28221|Deltaproteobacteria,2YTV2@29|Myxococcales	28221|Deltaproteobacteria	J	Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine cysteine desulfurase (IscS) system	ttcA	-	-	ko:K14058	-	-	-	-	ko00000,ko03016	-	-	-	ATP_bind_3
HKD2_k127_5637710_4	1192034.CAP_7191	1.997e-13	81.0	2ANKP@1|root,31DJW@2|Bacteria,1QAVS@1224|Proteobacteria,435BV@68525|delta/epsilon subdivisions,2WZPD@28221|Deltaproteobacteria,2Z2GM@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5637710_1	448385.sce4054	1.128e-78	291.0	COG0515@1|root,COG0515@2|Bacteria	448385.sce4054|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5638202_9	378806.STAUR_1462	8.278e-22	96.0	COG3185@1|root,COG3185@2|Bacteria,1MUVZ@1224|Proteobacteria,42R5V@68525|delta/epsilon subdivisions,2WMYF@28221|Deltaproteobacteria,2YU6U@29|Myxococcales	28221|Deltaproteobacteria	C	dioxygenase	hppD	-	1.13.11.27,1.13.11.46	ko:K00457,ko:K16421	ko00130,ko00261,ko00350,ko00360,ko01055,ko01100,ko01130,map00130,map00261,map00350,map00360,map01055,map01100,map01130	M00044	R01372,R02521,R06632	RC00505,RC00738,RC01471	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Glyoxalase
HKD2_k127_5638202_13	1461577.CCMH01000013_gene705	0.0004237	48.0	COG0399@1|root,COG0399@2|Bacteria,4PKRF@976|Bacteroidetes,1IJE8@117743|Flavobacteriia	976|Bacteroidetes	M	23S rRNA-intervening sequence protein	-	-	-	-	-	-	-	-	-	-	-	-	23S_rRNA_IVP
HKD2_k127_5638202_7	1163409.UUA_14224	4.848e-40	157.0	COG3803@1|root,COG3803@2|Bacteria,1RHYI@1224|Proteobacteria,1S40A@1236|Gammaproteobacteria,1XC02@135614|Xanthomonadales	135614|Xanthomonadales	S	Bacterial protein of unknown function (DUF924)	-	-	-	-	-	-	-	-	-	-	-	-	DUF924
HKD2_k127_5638202_0	1192034.CAP_4850	6.202e-122	406.0	COG3508@1|root,COG3508@2|Bacteria,1MV9G@1224|Proteobacteria,42U01@68525|delta/epsilon subdivisions,2WQQ3@28221|Deltaproteobacteria,2YU39@29|Myxococcales	28221|Deltaproteobacteria	C	homogentisate 12-dioxygenase	hgo	-	1.13.11.5	ko:K00451	ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120	M00044	R02519	RC00737	ko00000,ko00001,ko00002,ko01000	-	-	-	HgmA
HKD2_k127_5638202_5	314345.SPV1_00972	5.67e-62	235.0	COG3173@1|root,COG3173@2|Bacteria,1QXX9@1224|Proteobacteria	1224|Proteobacteria	S	Protein of unknown function (DUF1679)	-	-	-	-	-	-	-	-	-	-	-	-	EcKinase
HKD2_k127_5638202_4	1122604.JONR01000011_gene3616	5.803e-69	241.0	COG0778@1|root,COG0778@2|Bacteria,1RDJ6@1224|Proteobacteria,1SXRF@1236|Gammaproteobacteria,1XAGK@135614|Xanthomonadales	1224|Proteobacteria	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
HKD2_k127_5638202_6	378806.STAUR_1638	2.044e-53	205.0	COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,438S3@68525|delta/epsilon subdivisions,2X3YW@28221|Deltaproteobacteria,2YXN3@29|Myxococcales	28221|Deltaproteobacteria	T	GAF domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA
HKD2_k127_5638202_10	1396141.BATP01000027_gene1160	3.649e-15	87.0	COG2273@1|root,COG2755@1|root,COG3064@1|root,COG3291@1|root,COG5306@1|root,COG2273@2|Bacteria,COG2755@2|Bacteria,COG3064@2|Bacteria,COG3291@2|Bacteria,COG5306@2|Bacteria,46X9M@74201|Verrucomicrobia,2IV4C@203494|Verrucomicrobiae	203494|Verrucomicrobiae	EGM	Peptidase M60-like family	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin,M60-like_N,PA14,Peptidase_M60
HKD2_k127_5638202_3	1209072.ALBT01000022_gene4163	7.222e-72	247.0	COG4430@1|root,COG4430@2|Bacteria,1RJGC@1224|Proteobacteria,1S853@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Bacteriocin-protection, YdeI or OmpD-Associated	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801,OmdA
HKD2_k127_5638202_8	107635.AZUO01000001_gene3329	7.789e-22	98.0	COG3012@1|root,COG3012@2|Bacteria,1NGS9@1224|Proteobacteria,2UJIM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	SEC-C motif	-	-	-	-	-	-	-	-	-	-	-	-	SEC-C
HKD2_k127_5638202_12	1313304.CALK_0934	8.567e-08	58.0	2DTBQ@1|root,33JKP@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5638202_11	502025.Hoch_2837	1.278e-13	78.0	COG2608@1|root,COG2608@2|Bacteria,1PYGD@1224|Proteobacteria,43E4F@68525|delta/epsilon subdivisions,2X97W@28221|Deltaproteobacteria,2Z2H3@29|Myxococcales	28221|Deltaproteobacteria	P	mercury ion transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5638202_1	448385.sce4838	6.645e-85	287.0	COG3253@1|root,COG3253@2|Bacteria	2|Bacteria	S	peroxidase activity	ywfI	-	-	ko:K00435	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R11522	RC00884	ko00000,ko00001,ko01000	-	-	-	Chlor_dismutase
HKD2_k127_5638202_2	290397.Adeh_0431	5.217e-76	264.0	COG0708@1|root,COG0708@2|Bacteria,1MVII@1224|Proteobacteria,42NY7@68525|delta/epsilon subdivisions,2WIXK@28221|Deltaproteobacteria,2Z364@29|Myxococcales	28221|Deltaproteobacteria	L	Endonuclease/Exonuclease/phosphatase family	-	-	3.1.11.2	ko:K01142	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exo_endo_phos
HKD2_k127_5638683_1	1192034.CAP_5419	4.255e-119	400.0	COG2304@1|root,COG2304@2|Bacteria,1MUTS@1224|Proteobacteria,42R8X@68525|delta/epsilon subdivisions,2WN6U@28221|Deltaproteobacteria,2YWMS@29|Myxococcales	28221|Deltaproteobacteria	S	protein containing a von Willebrand factor type A (vWA) domain	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VWA
HKD2_k127_5638683_3	326427.Cagg_0629	9.469e-07	62.0	COG3243@1|root,COG3243@2|Bacteria,2GBDM@200795|Chloroflexi,376J0@32061|Chloroflexia	32061|Chloroflexia	I	PFAM alpha beta hydrolase fold	-	-	-	ko:K03821	ko00650,map00650	-	R04254	RC00004	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1
HKD2_k127_5638683_2	1192034.CAP_0709	3.304e-105	353.0	COG1092@1|root,COG1092@2|Bacteria,1MUGB@1224|Proteobacteria,42M7K@68525|delta/epsilon subdivisions,2WKKM@28221|Deltaproteobacteria,2YUWI@29|Myxococcales	28221|Deltaproteobacteria	J	S-adenosylmethionine-dependent methyltransferase	-	-	2.1.1.191	ko:K06969	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_SAM
HKD2_k127_5638683_4	1254432.SCE1572_44145	2.056e-06	60.0	COG0457@1|root,COG0457@2|Bacteria	1254432.SCE1572_44145|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5638683_0	1254432.SCE1572_40755	3.72e-144	463.0	COG0462@1|root,COG0462@2|Bacteria,1MW21@1224|Proteobacteria,42MI2@68525|delta/epsilon subdivisions,2WJ5W@28221|Deltaproteobacteria,2YUB9@29|Myxococcales	28221|Deltaproteobacteria	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	prs	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2848	Pribosyl_synth,Pribosyltran_N
HKD2_k127_5639599_1	1396141.BATP01000043_gene1931	1.336e-33	147.0	COG3735@1|root,COG3735@2|Bacteria,46VTS@74201|Verrucomicrobia,2IWHA@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	TraB family	-	-	-	-	-	-	-	-	-	-	-	-	TraB
HKD2_k127_5639599_0	448385.sce2026	9.881e-139	475.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,42MVV@68525|delta/epsilon subdivisions	1224|Proteobacteria	KLT	Family membership	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PP2C_2,Pkinase
HKD2_k127_5649357_0	1254432.SCE1572_10920	5.197e-54	201.0	COG0438@1|root,COG0438@2|Bacteria,1PY46@1224|Proteobacteria,4352X@68525|delta/epsilon subdivisions,2X94R@28221|Deltaproteobacteria,2Z1XM@29|Myxococcales	28221|Deltaproteobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_4_4,Glycos_transf_1
HKD2_k127_5649357_1	1254432.SCE1572_49835	6.058e-45	165.0	COG0065@1|root,COG0066@1|root,COG0065@2|Bacteria,COG0066@2|Bacteria,1MVYR@1224|Proteobacteria,42M5D@68525|delta/epsilon subdivisions,2WJ59@28221|Deltaproteobacteria,2YX5D@29|Myxococcales	28221|Deltaproteobacteria	E	Aconitase C-terminal domain	-	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
HKD2_k127_5651037_0	1254432.SCE1572_27270	9.222e-291	899.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,42M51@68525|delta/epsilon subdivisions,2WIPP@28221|Deltaproteobacteria,2YTYC@29|Myxococcales	28221|Deltaproteobacteria	NU	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB	pilB	-	-	ko:K02652	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE,T2SSE_N,cNMP_binding
HKD2_k127_5651037_4	1278073.MYSTI_05747	1.431e-43	173.0	COG1633@1|root,COG1633@2|Bacteria,1P131@1224|Proteobacteria,439DQ@68525|delta/epsilon subdivisions,2X4NM@28221|Deltaproteobacteria,2YZB1@29|Myxococcales	28221|Deltaproteobacteria	S	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5651037_1	4952.CAG82336	7.425e-82	282.0	COG0657@1|root,KOG1515@2759|Eukaryota,3A1CU@33154|Opisthokonta,3NZ98@4751|Fungi,3QKHV@4890|Ascomycota,3RVXJ@4891|Saccharomycetes	4751|Fungi	V	Carboxylesterase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3
HKD2_k127_5651037_3	246197.MXAN_5885	4.528e-58	208.0	COG3917@1|root,COG3917@2|Bacteria,1RA6I@1224|Proteobacteria,43DNK@68525|delta/epsilon subdivisions,2X6M0@28221|Deltaproteobacteria,2Z3BP@29|Myxococcales	28221|Deltaproteobacteria	G	DSBA-like thioredoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	DSBA
HKD2_k127_5651037_2	382464.ABSI01000011_gene3094	4.187e-58	209.0	COG0388@1|root,COG0388@2|Bacteria,46ZGG@74201|Verrucomicrobia,2IUQ5@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Carbon-nitrogen hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,CN_hydrolase
HKD2_k127_5651037_5	247639.MGP2080_11313	3.504e-29	124.0	COG2159@1|root,COG2159@2|Bacteria	2|Bacteria	E	amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
HKD2_k127_565122_1	1254432.SCE1572_18330	4.215e-60	214.0	2AMW0@1|root,31CSU@2|Bacteria,1Q9ME@1224|Proteobacteria,434GQ@68525|delta/epsilon subdivisions,2WYU2@28221|Deltaproteobacteria,2Z0M8@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_565122_3	121225.PHUM498090-PA	2.411e-08	63.0	KOG1037@1|root,KOG1037@2759|Eukaryota,38B7U@33154|Opisthokonta,3BBUM@33208|Metazoa,3CT5Y@33213|Bilateria,41VRJ@6656|Arthropoda,3SG42@50557|Insecta,3E9HS@33342|Paraneoptera	33208|Metazoa	KLO	Proposed nucleic acid binding domain	PARP1	GO:0000002,GO:0000003,GO:0000122,GO:0000166,GO:0000228,GO:0000302,GO:0000303,GO:0000305,GO:0000715,GO:0000723,GO:0000724,GO:0000725,GO:0000785,GO:0000790,GO:0000791,GO:0000976,GO:0000977,GO:0000981,GO:0001012,GO:0001067,GO:0001228,GO:0001817,GO:0001818,GO:0002009,GO:0002064,GO:0002065,GO:0002066,GO:0002225,GO:0002376,GO:0002520,GO:0002521,GO:0002573,GO:0002682,GO:0002684,GO:0002697,GO:0002699,GO:0002700,GO:0002702,GO:0002759,GO:0002760,GO:0002784,GO:0002786,GO:0002791,GO:0002792,GO:0002803,GO:0002805,GO:0002807,GO:0002808,GO:0002831,GO:0002833,GO:0002920,GO:0002922,GO:0003002,GO:0003006,GO:0003254,GO:0003674,GO:0003676,GO:0003677,GO:0003682,GO:0003690,GO:0003700,GO:0003824,GO:0003909,GO:0003910,GO:0003950,GO:0005102,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005635,GO:0005654,GO:0005667,GO:0005694,GO:0005700,GO:0005703,GO:0005719,GO:0005730,GO:0005737,GO:0005739,GO:0006139,GO:0006140,GO:0006163,GO:0006259,GO:0006260,GO:0006261,GO:0006266,GO:0006271,GO:0006273,GO:0006281,GO:0006282,GO:0006284,GO:0006289,GO:0006293,GO:0006294,GO:0006296,GO:0006302,GO:0006310,GO:0006351,GO:0006355,GO:0006357,GO:0006366,GO:0006464,GO:0006471,GO:0006508,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006915,GO:0006950,GO:0006952,GO:0006955,GO:0006963,GO:0006974,GO:0006979,GO:0006996,GO:0006997,GO:0007000,GO:0007005,GO:0007154,GO:0007163,GO:0007165,GO:0007166,GO:0007167,GO:0007178,GO:0007179,GO:0007275,GO:0007276,GO:0007281,GO:0007292,GO:0007389,GO:0007552,GO:0007610,GO:0008069,GO:0008104,GO:0008134,GO:0008150,GO:0008152,GO:0008219,GO:0009058,GO:0009059,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009266,GO:0009303,GO:0009314,GO:0009408,GO:0009410,GO:0009411,GO:0009416,GO:0009628,GO:0009653,GO:0009719,GO:0009725,GO:0009798,GO:0009888,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009950,GO:0009953,GO:0009966,GO:0009967,GO:0009987,GO:0010033,GO:0010035,GO:0010038,GO:0010043,GO:0010212,GO:0010243,GO:0010332,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010563,GO:0010604,GO:0010605,GO:0010611,GO:0010613,GO:0010628,GO:0010629,GO:0010639,GO:0010646,GO:0010647,GO:0010941,GO:0010942,GO:0010990,GO:0012501,GO:0012505,GO:0014070,GO:0014742,GO:0014743,GO:0015030,GO:0016043,GO:0016070,GO:0016072,GO:0016333,GO:0016334,GO:0016485,GO:0016540,GO:0016604,GO:0016740,GO:0016757,GO:0016763,GO:0016874,GO:0016886,GO:0017144,GO:0018130,GO:0018193,GO:0018209,GO:0018312,GO:0019219,GO:0019220,GO:0019222,GO:0019438,GO:0019538,GO:0019637,GO:0019693,GO:0019899,GO:0019900,GO:0019901,GO:0019953,GO:0022412,GO:0022414,GO:0022607,GO:0022616,GO:0023019,GO:0023051,GO:0023052,GO:0023056,GO:0030097,GO:0030099,GO:0030154,GO:0030225,GO:0030331,GO:0030534,GO:0030575,GO:0030576,GO:0030707,GO:0030808,GO:0030809,GO:0030855,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0031334,GO:0031347,GO:0031349,GO:0031960,GO:0031967,GO:0031974,GO:0031975,GO:0031981,GO:0032042,GO:0032101,GO:0032103,GO:0032200,GO:0032204,GO:0032205,GO:0032501,GO:0032502,GO:0032504,GO:0032507,GO:0032660,GO:0032700,GO:0032774,GO:0032868,GO:0032869,GO:0032870,GO:0032879,GO:0032880,GO:0032991,GO:0032993,GO:0033036,GO:0033043,GO:0033044,GO:0033143,GO:0033145,GO:0033146,GO:0033148,GO:0033365,GO:0033554,GO:0033683,GO:0033993,GO:0034248,GO:0034250,GO:0034504,GO:0034599,GO:0034605,GO:0034613,GO:0034614,GO:0034622,GO:0034641,GO:0034644,GO:0034645,GO:0034654,GO:0034660,GO:0035079,GO:0035080,GO:0035257,GO:0035258,GO:0035363,GO:0036094,GO:0036211,GO:0040008,GO:0040009,GO:0042220,GO:0042221,GO:0042391,GO:0042393,GO:0042493,GO:0042592,GO:0042769,GO:0042802,GO:0042826,GO:0042981,GO:0043067,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043254,GO:0043279,GO:0043388,GO:0043412,GO:0043434,GO:0043484,GO:0043502,GO:0043504,GO:0043523,GO:0043565,GO:0043900,GO:0043902,GO:0043933,GO:0044030,GO:0044057,GO:0044085,GO:0044087,GO:0044089,GO:0044093,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044422,GO:0044424,GO:0044427,GO:0044428,GO:0044444,GO:0044446,GO:0044451,GO:0044454,GO:0044464,GO:0044703,GO:0045087,GO:0045185,GO:0045595,GO:0045597,GO:0045739,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0045936,GO:0045944,GO:0045980,GO:0046034,GO:0046332,GO:0046483,GO:0047485,GO:0048037,GO:0048148,GO:0048468,GO:0048477,GO:0048513,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048534,GO:0048545,GO:0048583,GO:0048584,GO:0048609,GO:0048729,GO:0048731,GO:0048856,GO:0048869,GO:0048878,GO:0050662,GO:0050707,GO:0050708,GO:0050709,GO:0050710,GO:0050776,GO:0050778,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0050801,GO:0050879,GO:0050881,GO:0050882,GO:0050896,GO:0051046,GO:0051048,GO:0051049,GO:0051051,GO:0051052,GO:0051053,GO:0051054,GO:0051094,GO:0051098,GO:0051099,GO:0051101,GO:0051103,GO:0051128,GO:0051129,GO:0051130,GO:0051171,GO:0051172,GO:0051173,GO:0051174,GO:0051179,GO:0051223,GO:0051224,GO:0051235,GO:0051239,GO:0051240,GO:0051241,GO:0051252,GO:0051253,GO:0051254,GO:0051276,GO:0051287,GO:0051385,GO:0051427,GO:0051457,GO:0051604,GO:0051606,GO:0051641,GO:0051651,GO:0051704,GO:0051716,GO:0051881,GO:0051900,GO:0051901,GO:0055086,GO:0060249,GO:0060255,GO:0060341,GO:0060359,GO:0060390,GO:0060391,GO:0060429,GO:0062012,GO:0062014,GO:0065003,GO:0065004,GO:0065007,GO:0065008,GO:0065009,GO:0070013,GO:0070201,GO:0070212,GO:0070412,GO:0070727,GO:0070848,GO:0070887,GO:0070911,GO:0071214,GO:0071241,GO:0071248,GO:0071294,GO:0071310,GO:0071363,GO:0071375,GO:0071417,GO:0071450,GO:0071451,GO:0071478,GO:0071482,GO:0071495,GO:0071559,GO:0071560,GO:0071704,GO:0071824,GO:0071840,GO:0072347,GO:0072521,GO:0072595,GO:0080090,GO:0080134,GO:0080135,GO:0090087,GO:0090092,GO:0090100,GO:0090257,GO:0090304,GO:0090305,GO:0097159,GO:0097305,GO:0097659,GO:0098687,GO:0098781,GO:0104004,GO:0140096,GO:0140097,GO:0140110,GO:1900180,GO:1900182,GO:1900371,GO:1900372,GO:1900407,GO:1900424,GO:1900426,GO:1900542,GO:1900543,GO:1901135,GO:1901214,GO:1901216,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901576,GO:1901652,GO:1901653,GO:1901654,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902175,GO:1902531,GO:1902679,GO:1902680,GO:1902882,GO:1903201,GO:1903203,GO:1903376,GO:1903506,GO:1903507,GO:1903508,GO:1903516,GO:1903518,GO:1903530,GO:1903531,GO:1903578,GO:1903579,GO:1903827,GO:1903829,GO:1904044,GO:1904181,GO:1904356,GO:1904357,GO:1904645,GO:1904646,GO:1904760,GO:1904762,GO:1904950,GO:1905076,GO:1905077,GO:1990404,GO:1990837,GO:1990966,GO:2000112,GO:2000113,GO:2000677,GO:2000679,GO:2001020,GO:2001022,GO:2001141,GO:2001169,GO:2001170,GO:2001233,GO:2001242,GO:2001251	2.4.2.30	ko:K10798	ko03410,ko04210,ko04212,ko04214,ko04217,map03410,map04210,map04212,map04214,map04217	M00296	-	-	ko00000,ko00001,ko00002,ko01000,ko03032,ko03036,ko03400	-	-	-	BRCT,PADR1,PARP,PARP_reg,WGR,zf-PARP
HKD2_k127_565122_2	1267533.KB906735_gene4884	6.95e-42	168.0	COG3511@1|root,COG3511@2|Bacteria,3Y870@57723|Acidobacteria	57723|Acidobacteria	M	Phosphoesterase family	-	-	-	-	-	-	-	-	-	-	-	-	Phosphoesterase
HKD2_k127_565122_0	1123023.JIAI01000002_gene5476	1.061e-73	256.0	COG0030@1|root,COG0030@2|Bacteria,2GIZ8@201174|Actinobacteria,4DYTH@85010|Pseudonocardiales	201174|Actinobacteria	J	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
HKD2_k127_5659758_1	1254432.SCE1572_12480	4.881e-58	216.0	COG0642@1|root,COG3850@1|root,COG2205@2|Bacteria,COG3850@2|Bacteria,1N9SU@1224|Proteobacteria,43BZY@68525|delta/epsilon subdivisions,2X39W@28221|Deltaproteobacteria,2YV13@29|Myxococcales	28221|Deltaproteobacteria	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
HKD2_k127_5659758_0	1278073.MYSTI_05877	1.469e-98	326.0	COG0745@1|root,COG0745@2|Bacteria,1MVCB@1224|Proteobacteria,42RGE@68525|delta/epsilon subdivisions,2WNF7@28221|Deltaproteobacteria,2YUAH@29|Myxococcales	28221|Deltaproteobacteria	K	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
HKD2_k127_5665215_2	1192034.CAP_7527	6.384e-30	121.0	COG1595@1|root,COG1595@2|Bacteria,1QAB8@1224|Proteobacteria,434YB@68525|delta/epsilon subdivisions,2WZ98@28221|Deltaproteobacteria,2Z1MI@29|Myxococcales	28221|Deltaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD2_k127_5665215_3	1192034.CAP_7525	7.956e-28	125.0	2A4WF@1|root,30TI4@2|Bacteria,1PDD5@1224|Proteobacteria,435F2@68525|delta/epsilon subdivisions,2WZSM@28221|Deltaproteobacteria,2Z2NW@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5665215_1	378806.STAUR_1608	9.512e-37	155.0	COG1560@1|root,COG1560@2|Bacteria,1MVNI@1224|Proteobacteria,42N6U@68525|delta/epsilon subdivisions,2WQ3X@28221|Deltaproteobacteria,2YYM4@29|Myxococcales	28221|Deltaproteobacteria	M	Bacterial lipid A biosynthesis acyltransferase	htrB	-	2.3.1.241	ko:K02517	ko00540,ko01100,map00540,map01100	M00060	R05146	RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Lip_A_acyltrans
HKD2_k127_5665215_0	452637.Oter_3727	3.52e-92	314.0	COG1475@1|root,COG1475@2|Bacteria	2|Bacteria	K	chromosome segregation	-	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
HKD2_k127_5665215_4	1207063.P24_17912	1.492e-27	129.0	COG5285@1|root,COG5285@2|Bacteria,1RC96@1224|Proteobacteria,2U5V4@28211|Alphaproteobacteria,2JU95@204441|Rhodospirillales	204441|Rhodospirillales	Q	Phytanoyl-CoA dioxygenase (PhyH)	-	-	-	-	-	-	-	-	-	-	-	-	PhyH
HKD2_k127_56746_9	269799.Gmet_3329	1.65e-30	135.0	COG0680@1|root,COG0680@2|Bacteria,1RE1C@1224|Proteobacteria,42REH@68525|delta/epsilon subdivisions,2WPXK@28221|Deltaproteobacteria,43VTP@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	PFAM peptidase M52 hydrogen uptake protein	hyaP	-	-	ko:K03605	-	-	-	-	ko00000,ko01000,ko01002	-	-	iAF987.Gmet_3329	HycI
HKD2_k127_56746_7	1232410.KI421412_gene145	1.278e-45	189.0	COG1969@1|root,COG1969@2|Bacteria,1MU87@1224|Proteobacteria,42NQ3@68525|delta/epsilon subdivisions,2X8MJ@28221|Deltaproteobacteria,43TMS@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Domain of unknown function (DUF4405)	-	-	-	-	-	-	-	-	-	-	-	-	Ni_hydr_CYTB
HKD2_k127_56746_0	1121918.ARWE01000001_gene3504	8.65e-260	832.0	COG0374@1|root,COG0374@2|Bacteria,1MWFJ@1224|Proteobacteria,42M4S@68525|delta/epsilon subdivisions,2WJQS@28221|Deltaproteobacteria,43TIF@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Nickel-dependent hydrogenase	hyaL	-	1.12.99.6	ko:K06281	ko00633,ko01120,map00633,map01120	-	R08034	RC00250	ko00000,ko00001,ko01000	-	-	-	NiFeSe_Hases
HKD2_k127_56746_2	443143.GM18_0460	1.668e-138	449.0	COG1740@1|root,COG1740@2|Bacteria,1MWAC@1224|Proteobacteria,42MI0@68525|delta/epsilon subdivisions,2WIW4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	TIGRFAM hydrogenase (NiFe) small subunit (hydA)	hyaS	-	1.12.2.1,1.12.99.6	ko:K06282,ko:K18008	ko00633,ko01120,map00633,map01120	-	R08034	RC00250	ko00000,ko00001,ko01000	-	-	iAF987.Gmet_3332	NiFe_hyd_SSU_C,Oxidored_q6,TAT_signal
HKD2_k127_56746_6	1227488.C477_15345	8.375e-63	228.0	COG1575@1|root,arCOG00480@2157|Archaea,2XT1M@28890|Euryarchaeota,23TNU@183963|Halobacteria	183963|Halobacteria	H	Belongs to the MenA family. Type 1 subfamily	menA	-	2.5.1.74	ko:K02548	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R05617,R06858,R10757	RC02935,RC02936,RC03264	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
HKD2_k127_56746_4	1121033.AUCF01000001_gene2301	7.66e-109	371.0	COG1902@1|root,COG1902@2|Bacteria,1MVIX@1224|Proteobacteria,2TT2F@28211|Alphaproteobacteria,2JRIF@204441|Rhodospirillales	204441|Rhodospirillales	C	COG1902 NADH flavin oxidoreductases, Old Yellow Enzyme family	-	-	-	ko:K10680	ko00633,ko01120,map00633,map01120	-	R08014,R08017,R08042	RC00250	ko00000,ko00001,ko01000	-	-	-	Oxidored_FMN
HKD2_k127_56746_10	1192034.CAP_5412	1.736e-27	130.0	COG0003@1|root,COG0003@2|Bacteria,1NA7C@1224|Proteobacteria,42V2J@68525|delta/epsilon subdivisions,2WS25@28221|Deltaproteobacteria,2YUZS@29|Myxococcales	28221|Deltaproteobacteria	P	Anion-transporting ATPase	-	-	3.6.3.16	ko:K01551	-	-	-	-	ko00000,ko01000,ko02000	3.A.19.1,3.A.21.1,3.A.4.1	-	-	ArsA_ATPase
HKD2_k127_56746_11	1449069.JMLO01000004_gene3656	2.154e-23	116.0	COG0003@1|root,COG0003@2|Bacteria,2GJYN@201174|Actinobacteria,4FVKW@85025|Nocardiaceae	201174|Actinobacteria	D	Anion-transporting ATPase	-	-	-	-	-	-	-	-	-	-	-	-	ArsA_ATPase
HKD2_k127_56746_3	1254432.SCE1572_23055	1.869e-114	387.0	COG1355@1|root,COG1355@2|Bacteria,1N5H1@1224|Proteobacteria,42TIN@68525|delta/epsilon subdivisions,2WR24@28221|Deltaproteobacteria,2Z1BF@29|Myxococcales	28221|Deltaproteobacteria	S	Memo-like protein	-	-	-	ko:K06990	-	-	-	-	ko00000,ko04812	-	-	-	Memo
HKD2_k127_56746_8	435591.BDI_2976	1.234e-36	154.0	COG1397@1|root,COG1397@2|Bacteria,4NY3F@976|Bacteroidetes,2FZQI@200643|Bacteroidia,2313J@171551|Porphyromonadaceae	976|Bacteroidetes	O	ADP-ribosylglycohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_56746_1	502025.Hoch_4977	1.234e-179	577.0	COG1061@1|root,COG1061@2|Bacteria,1PPY3@1224|Proteobacteria,43AP9@68525|delta/epsilon subdivisions	1224|Proteobacteria	L	SNF2 family N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	ERCC3_RAD25_C,Helicase_C,PLDc_2,ResIII
HKD2_k127_56746_5	502025.Hoch_4976	1.432e-82	287.0	COG3372@1|root,COG3372@2|Bacteria,1NVX4@1224|Proteobacteria,4385X@68525|delta/epsilon subdivisions,2X3FQ@28221|Deltaproteobacteria,2YVWR@29|Myxococcales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF790)	-	-	-	ko:K09744	-	-	-	-	ko00000	-	-	-	DUF790
HKD2_k127_5676680_1	985665.HPL003_00695	1.414e-44	169.0	COG0624@1|root,COG0624@2|Bacteria,1TP2D@1239|Firmicutes,4HB9G@91061|Bacilli,26SYE@186822|Paenibacillaceae	91061|Bacilli	E	peptidase M20	dapE	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
HKD2_k127_5676680_0	448385.sce0297	5.795e-62	219.0	COG0632@1|root,COG0632@2|Bacteria,1MWJR@1224|Proteobacteria,42RPS@68525|delta/epsilon subdivisions,2WPH5@28221|Deltaproteobacteria,2Z0ZS@29|Myxococcales	28221|Deltaproteobacteria	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB	ruvA	-	3.6.4.12	ko:K03550	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HHH_5,RuvA_C,RuvA_N
HKD2_k127_5678665_0	1254432.SCE1572_46815	3.987e-110	372.0	COG3903@1|root,COG3903@2|Bacteria	2|Bacteria	K	ADP binding	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5682766_0	743299.Acife_0982	4.757e-104	351.0	COG0621@1|root,COG0621@2|Bacteria,1MURS@1224|Proteobacteria,1RMD8@1236|Gammaproteobacteria,2NBZ1@225057|Acidithiobacillales	225057|Acidithiobacillales	J	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine	miaB	-	2.8.4.3	ko:K06168	-	-	R10645,R10646,R10647	RC00003,RC00980,RC03221,RC03222	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
HKD2_k127_5682766_1	1192034.CAP_3998	3.397e-51	186.0	COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,42Z0F@68525|delta/epsilon subdivisions,2WTWA@28221|Deltaproteobacteria,2YUMY@29|Myxococcales	28221|Deltaproteobacteria	I	AMP-binding enzyme	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
HKD2_k127_5697477_0	1192034.CAP_5011	1.487e-221	696.0	COG0029@1|root,COG0029@2|Bacteria,1RBQW@1224|Proteobacteria,43BKD@68525|delta/epsilon subdivisions,2WJNK@28221|Deltaproteobacteria,2YUGG@29|Myxococcales	28221|Deltaproteobacteria	H	Catalyzes the oxidation of L-aspartate to iminoaspartate	nadB	-	1.4.3.16	ko:K00278	ko00250,ko00760,ko01100,map00250,map00760,map01100	M00115	R00357,R00481	RC00006,RC02566	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
HKD2_k127_5715663_0	1192034.CAP_7313	8.059e-309	983.0	COG1404@1|root,COG1404@2|Bacteria	2|Bacteria	O	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase,Big_2,CBM_25,Calx-beta,DUF4114,P_proprotein,Peptidase_S8,SBBP,SLH,VCBS
HKD2_k127_5715663_1	448385.sce0622	3.261e-90	300.0	COG0745@1|root,COG0745@2|Bacteria,1NUNK@1224|Proteobacteria,43CMR@68525|delta/epsilon subdivisions,2X7UV@28221|Deltaproteobacteria,2Z3I4@29|Myxococcales	28221|Deltaproteobacteria	K	Cro/C1-type HTH DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3,Response_reg
HKD2_k127_573344_0	1192034.CAP_2417	6.405e-180	584.0	COG2937@1|root,COG2937@2|Bacteria,1MWZ6@1224|Proteobacteria,42MN4@68525|delta/epsilon subdivisions,2WJJ5@28221|Deltaproteobacteria,2YW2Y@29|Myxococcales	28221|Deltaproteobacteria	I	Belongs to the GPAT DAPAT family	plsB	-	2.3.1.15	ko:K00631	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
HKD2_k127_573344_1	1192034.CAP_2778	5.329e-56	198.0	COG0346@1|root,COG0346@2|Bacteria,1RCYU@1224|Proteobacteria,42URG@68525|delta/epsilon subdivisions,2WNDG@28221|Deltaproteobacteria,2YVX9@29|Myxococcales	28221|Deltaproteobacteria	E	Glyoxalase-like domain	mceE	-	5.1.99.1	ko:K05606	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00375,M00376,M00741	R02765,R09979	RC00780,RC02739	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyoxalase_4
HKD2_k127_573344_2	511051.CSE_07610	0.0005739	51.0	COG1470@1|root,COG1470@2|Bacteria	2|Bacteria	S	cell adhesion involved in biofilm formation	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,DUF4384,DUF4625,NPCBM_assoc,PEGA
HKD2_k127_5733445_1	189753.AXAS01000013_gene5867	3.401e-87	306.0	COG4257@1|root,COG4257@2|Bacteria,1QR8W@1224|Proteobacteria,2TRQ1@28211|Alphaproteobacteria,3JSJF@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	V	Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid	-	-	-	ko:K18235	-	-	-	-	ko00000,ko01000,ko01504	-	-	-	-
HKD2_k127_5733445_0	1192034.CAP_3357	1.32e-97	349.0	COG0515@1|root,COG0515@2|Bacteria,1Q38J@1224|Proteobacteria,438ZJ@68525|delta/epsilon subdivisions,2X44T@28221|Deltaproteobacteria,2YY98@29|Myxococcales	28221|Deltaproteobacteria	KLT	Protein kinase domain	masK	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HKD2_k127_5733445_4	1254432.SCE1572_22990	2.053e-30	135.0	COG3628@1|root,COG3628@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5733445_3	1254432.SCE1572_02735	3.819e-57	220.0	COG0226@1|root,COG0226@2|Bacteria	2|Bacteria	P	phosphate ion binding	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5733445_2	502025.Hoch_1397	2.561e-60	216.0	COG2518@1|root,COG2518@2|Bacteria	2|Bacteria	O	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	-	-	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	Met_10,Methyltransf_21,rRNA_methylase
HKD2_k127_5741069_3	1242864.D187_006508	1.395e-94	321.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,42QEI@68525|delta/epsilon subdivisions,2WM5N@28221|Deltaproteobacteria,2Z33T@29|Myxococcales	28221|Deltaproteobacteria	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PEGA,Pkinase
HKD2_k127_5741069_0	448385.sce4279	2.979e-217	705.0	2C4HX@1|root,2Z9XP@2|Bacteria,1MY22@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5741069_1	1254432.SCE1572_25830	6.503e-213	669.0	COG0621@1|root,COG0621@2|Bacteria,1MU7N@1224|Proteobacteria,42MRJ@68525|delta/epsilon subdivisions,2WITA@28221|Deltaproteobacteria,2YUDC@29|Myxococcales	28221|Deltaproteobacteria	J	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12	rimO	-	2.8.4.4	ko:K14441	-	-	R10652	RC00003,RC03217	ko00000,ko01000,ko03009	-	-	-	Radical_SAM,TRAM,UPF0004
HKD2_k127_5741069_2	383372.Rcas_3359	2.572e-131	432.0	COG0505@1|root,COG0505@2|Bacteria,2G5S1@200795|Chloroflexi,3755X@32061|Chloroflexia	32061|Chloroflexia	F	TIGRFAM carbamoyl-phosphate synthase, small subunit	carA	-	6.3.5.5	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_sm_chain,GATase
HKD2_k127_5741069_4	1192034.CAP_1199	1.057e-54	203.0	COG4700@1|root,COG4700@2|Bacteria	2|Bacteria	T	PFAM Protein kinase domain	-	-	-	ko:K08309	-	-	-	-	ko00000,ko01000,ko01011	-	GH23	-	PLDc_N,TPR_16,TPR_19,TPR_4,TPR_6,TPR_8
HKD2_k127_5748860_1	1192034.CAP_3102	5.492e-138	451.0	COG1092@1|root,COG1092@2|Bacteria,1MUGB@1224|Proteobacteria,42M7K@68525|delta/epsilon subdivisions,2WKKM@28221|Deltaproteobacteria,2YUWI@29|Myxococcales	28221|Deltaproteobacteria	J	S-adenosylmethionine-dependent methyltransferase	-	-	2.1.1.191	ko:K06969	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_SAM,Methyltransf_25
HKD2_k127_5748860_6	1192034.CAP_3103	6.245e-67	252.0	COG0561@1|root,COG0561@2|Bacteria,1R4WX@1224|Proteobacteria,42P98@68525|delta/epsilon subdivisions,2WJWW@28221|Deltaproteobacteria,2YVRM@29|Myxococcales	28221|Deltaproteobacteria	S	haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_3
HKD2_k127_5748860_0	1254432.SCE1572_00025	6.207e-152	490.0	COG4992@1|root,COG4992@2|Bacteria,1MV3C@1224|Proteobacteria,42MHH@68525|delta/epsilon subdivisions,2WIMW@28221|Deltaproteobacteria,2YTVG@29|Myxococcales	28221|Deltaproteobacteria	E	acetylornithine aminotransferase	argD	-	2.6.1.11,2.6.1.17	ko:K00821	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	iAF987.Gmet_0204	Aminotran_3
HKD2_k127_5748860_4	1192034.CAP_3126	1.392e-98	357.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,42M2R@68525|delta/epsilon subdivisions,2WJ4J@28221|Deltaproteobacteria,2YTUI@29|Myxococcales	28221|Deltaproteobacteria	P	copper-translocating P-type ATPase	-	-	3.6.3.3,3.6.3.5	ko:K01534	-	-	-	-	ko00000,ko01000	3.A.3.6	-	-	E1-E2_ATPase,Hydrolase
HKD2_k127_5748860_9	557598.LHK_03034	2.416e-11	67.0	COG2608@1|root,COG2608@2|Bacteria,1NGBD@1224|Proteobacteria,2VXV9@28216|Betaproteobacteria,2KSB6@206351|Neisseriales	206351|Neisseriales	C	Heavy metal-associated domain protein	-	-	-	ko:K07213	ko04978,map04978	-	-	-	ko00000,ko00001	-	-	-	HMA
HKD2_k127_5748860_2	448385.sce0855	3.951e-114	417.0	COG0515@1|root,COG0515@2|Bacteria	448385.sce0855|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5748860_8	62928.azo3774	1.884e-45	179.0	COG0515@1|root,COG0515@2|Bacteria,1P64D@1224|Proteobacteria	1224|Proteobacteria	KLT	serine threonine protein kinase	pkn9	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HKD2_k127_5748860_5	1192034.CAP_7624	4.245e-88	300.0	COG0564@1|root,COG0564@2|Bacteria,1MUBN@1224|Proteobacteria,42MBA@68525|delta/epsilon subdivisions,2WKX9@28221|Deltaproteobacteria,2YUX4@29|Myxococcales	28221|Deltaproteobacteria	J	Responsible for synthesis of pseudouridine from uracil	coaE	-	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	CoaE,PseudoU_synth_2,S4
HKD2_k127_5748860_3	234267.Acid_5283	1.775e-107	359.0	COG0436@1|root,COG0436@2|Bacteria,3Y2VQ@57723|Acidobacteria	57723|Acidobacteria	E	PFAM Aminotransferase class I and II	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
HKD2_k127_5771741_0	1162668.LFE_0929	3.397e-59	218.0	COG0841@1|root,COG0841@2|Bacteria,3J0ZG@40117|Nitrospirae	40117|Nitrospirae	V	AcrB/AcrD/AcrF family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
HKD2_k127_5771741_2	196367.JNFG01000012_gene5954	8.476e-17	95.0	COG0845@1|root,COG0845@2|Bacteria,1NQZ0@1224|Proteobacteria,2WEMD@28216|Betaproteobacteria,1KGIH@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_D23
HKD2_k127_5771741_1	234267.Acid_5886	1.525e-21	109.0	COG1538@1|root,COG1538@2|Bacteria,3Y3KB@57723|Acidobacteria	57723|Acidobacteria	MU	outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
HKD2_k127_5771741_3	929704.Myrod_2413	3.169e-14	75.0	COG1846@1|root,COG1846@2|Bacteria,4NT8S@976|Bacteroidetes,1I43X@117743|Flavobacteriia	976|Bacteroidetes	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
HKD2_k127_5775805_2	278963.ATWD01000001_gene2588	1.172e-98	338.0	COG2855@1|root,COG2855@2|Bacteria,3Y3R4@57723|Acidobacteria,2JHTG@204432|Acidobacteriia	204432|Acidobacteriia	S	Conserved hypothetical protein 698	-	-	-	-	-	-	-	-	-	-	-	-	Cons_hypoth698
HKD2_k127_5775805_0	118166.JH976537_gene3678	7.553e-144	466.0	COG0491@1|root,COG0607@1|root,COG0491@2|Bacteria,COG0607@2|Bacteria,1G0CZ@1117|Cyanobacteria,1HERQ@1150|Oscillatoriales	1117|Cyanobacteria	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B,Rhodanese
HKD2_k127_5775805_3	1192034.CAP_6165	6.665e-30	136.0	COG2924@1|root,COG2924@2|Bacteria	2|Bacteria	CO	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes	yggX	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0009987,GO:0033554,GO:0034599,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0070887	-	-	-	-	-	-	-	-	-	-	Iron_traffic
HKD2_k127_5775805_1	1192034.CAP_7016	4.38e-138	454.0	COG0493@1|root,COG0543@1|root,COG0493@2|Bacteria,COG0543@2|Bacteria,1Q2ZJ@1224|Proteobacteria,438P5@68525|delta/epsilon subdivisions,2X8TH@28221|Deltaproteobacteria,2YXE6@29|Myxococcales	28221|Deltaproteobacteria	CEH	Pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2
HKD2_k127_589500_1	1192034.CAP_3914	1.936e-145	482.0	COG0823@1|root,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	-	-	-	-	-	-	-	-	-	-	DUF4214,HYR,PD40,PKD,REJ
HKD2_k127_589500_2	1192034.CAP_0044	7.168e-124	401.0	COG1024@1|root,COG1024@2|Bacteria,1MWZC@1224|Proteobacteria,43AB6@68525|delta/epsilon subdivisions,2X259@28221|Deltaproteobacteria,2YZEP@29|Myxococcales	28221|Deltaproteobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
HKD2_k127_589500_3	448385.sce5923	1.505e-30	123.0	COG0236@1|root,COG0236@2|Bacteria,1N6RU@1224|Proteobacteria,42V26@68525|delta/epsilon subdivisions,2WQ0Y@28221|Deltaproteobacteria,2Z2KY@29|Myxococcales	28221|Deltaproteobacteria	IQ	Phosphopantetheine attachment site	acpP-1	-	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
HKD2_k127_589500_0	1192034.CAP_0046	5.292e-170	557.0	COG0304@1|root,COG0304@2|Bacteria,1N91E@1224|Proteobacteria,42N4J@68525|delta/epsilon subdivisions,2WIY7@28221|Deltaproteobacteria,2Z361@29|Myxococcales	28221|Deltaproteobacteria	IQ	Beta-ketoacyl synthase, C-terminal domain	-	-	2.3.1.179,2.3.1.41	ko:K00647,ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
HKD2_k127_5905915_1	1443113.LC20_01880	2.156e-123	406.0	COG1164@1|root,COG1164@2|Bacteria,1MUYZ@1224|Proteobacteria,1RYXN@1236|Gammaproteobacteria,41DAA@629|Yersinia	1236|Gammaproteobacteria	E	Peptidase family M3	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M3
HKD2_k127_5905915_5	215803.DB30_4298	7.855e-13	83.0	COG4447@1|root,COG4447@2|Bacteria,1PK4F@1224|Proteobacteria,437G7@68525|delta/epsilon subdivisions,2XA3A@28221|Deltaproteobacteria,2YVKV@29|Myxococcales	28221|Deltaproteobacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5905915_0	243233.MCA2161	2.764e-188	622.0	COG3206@1|root,COG3206@2|Bacteria,1QX0J@1224|Proteobacteria,1RZ5A@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	protein involved in exopolysaccharide biosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5905915_2	1192034.CAP_5633	4.641e-90	313.0	COG4402@1|root,COG4402@2|Bacteria	2|Bacteria	S	Uncharacterized protein conserved in bacteria (DUF2330)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2330
HKD2_k127_5905915_3	1254432.SCE1572_31010	3.83e-65	241.0	COG4402@1|root,COG4402@2|Bacteria,1QA5C@1224|Proteobacteria,434UU@68525|delta/epsilon subdivisions,2WZ5W@28221|Deltaproteobacteria,2Z1E4@29|Myxococcales	28221|Deltaproteobacteria	S	Uncharacterized protein conserved in bacteria (DUF2330)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2330
HKD2_k127_591600_0	448385.sce8182	2.543e-105	350.0	COG2256@1|root,COG2256@2|Bacteria,1MUVS@1224|Proteobacteria,42M9X@68525|delta/epsilon subdivisions,2WJ7E@28221|Deltaproteobacteria,2YU66@29|Myxococcales	28221|Deltaproteobacteria	L	AAA C-terminal domain	rarA	-	-	ko:K07478	-	-	-	-	ko00000	-	-	-	AAA,AAA_assoc_2,MgsA_C,RuvB_N
HKD2_k127_591600_2	1192034.CAP_0024	7.683e-09	66.0	COG0810@1|root,COG0810@2|Bacteria,1R65W@1224|Proteobacteria,42XJ0@68525|delta/epsilon subdivisions,2WT3A@28221|Deltaproteobacteria,2YYW2@29|Myxococcales	28221|Deltaproteobacteria	M	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins	-	-	-	-	-	-	-	-	-	-	-	-	TonB_C
HKD2_k127_591600_3	1522072.IL54_3038	8.186e-05	56.0	COG0457@1|root,COG0457@2|Bacteria,1REXI@1224|Proteobacteria,2UB1S@28211|Alphaproteobacteria,2K3CM@204457|Sphingomonadales	204457|Sphingomonadales	S	Putative 2OG-Fe(II) oxygenase	-	-	-	-	-	-	-	-	-	-	-	-	2OG-FeII_Oxy_5,TPR_16,TPR_8
HKD2_k127_591600_1	1254432.SCE1572_47570	1.54e-40	154.0	COG0325@1|root,COG0325@2|Bacteria,1MWN7@1224|Proteobacteria,42PSG@68525|delta/epsilon subdivisions,2WKYN@28221|Deltaproteobacteria,2YZQW@29|Myxococcales	28221|Deltaproteobacteria	S	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis	yggS	-	-	ko:K06997	-	-	-	-	ko00000	-	-	-	Ala_racemase_N
HKD2_k127_591870_1	1254432.SCE1572_00790	8.98e-16	91.0	COG3391@1|root,COG3391@2|Bacteria,1Q2JN@1224|Proteobacteria,4386H@68525|delta/epsilon subdivisions,2X9ZH@28221|Deltaproteobacteria,2YVZH@29|Myxococcales	28221|Deltaproteobacteria	S	Beta-L-arabinofuranosidase, GH127	-	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3,Stig1
HKD2_k127_591870_2	935837.JAEK01000002_gene2033	0.0005588	51.0	COG1846@1|root,COG1846@2|Bacteria,1VBQ1@1239|Firmicutes,4HMXC@91061|Bacilli,1ZIKI@1386|Bacillus	91061|Bacilli	K	COG1846 Transcriptional regulators	-	-	-	-	-	-	-	-	-	-	-	-	HTH_27,MarR,MarR_2
HKD2_k127_591870_0	926550.CLDAP_24920	9.838e-19	87.0	COG0451@1|root,COG0451@2|Bacteria,2G8B1@200795|Chloroflexi	200795|Chloroflexi	GM	Polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
HKD2_k127_5922388_1	1254432.SCE1572_22600	3.5e-76	262.0	2BKCR@1|root,32ETA@2|Bacteria,1RJ21@1224|Proteobacteria,430EX@68525|delta/epsilon subdivisions,2WVVF@28221|Deltaproteobacteria,2YUQK@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5922388_2	469383.Cwoe_5363	1.82e-14	83.0	COG3540@1|root,COG3540@2|Bacteria	2|Bacteria	P	PhoD-like phosphatase	-	-	3.1.3.1	ko:K01113	ko00790,ko01100,ko02020,map00790,map01100,map02020	M00126	R04620	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Laminin_G_3,PhoD
HKD2_k127_5922388_0	1254432.SCE1572_03615	1.228e-91	312.0	COG0177@1|root,COG0177@2|Bacteria,1RAK3@1224|Proteobacteria,42M4V@68525|delta/epsilon subdivisions,2WPRX@28221|Deltaproteobacteria,2YW8E@29|Myxococcales	28221|Deltaproteobacteria	L	Protein of unknown function (DUF2400)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2400
HKD2_k127_5948344_0	383372.Rcas_0264	1.208e-99	338.0	COG5184@1|root,COG5184@2|Bacteria,2G8WU@200795|Chloroflexi,3765G@32061|Chloroflexia	32061|Chloroflexia	DZ	PFAM regulator of chromosome condensation, RCC1	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5948344_1	886293.Sinac_5561	2.17e-97	334.0	COG0612@1|root,COG0612@2|Bacteria,2IYKK@203682|Planctomycetes	203682|Planctomycetes	S	PFAM Peptidase M16 inactive domain	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
HKD2_k127_5948344_2	215803.DB30_3531	6.614e-10	72.0	COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,42NYP@68525|delta/epsilon subdivisions,2WIPJ@28221|Deltaproteobacteria,2YXKT@29|Myxococcales	28221|Deltaproteobacteria	S	Insulinase (Peptidase family M16)	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
HKD2_k127_5964314_1	290397.Adeh_2789	3.866e-172	548.0	COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,42MEI@68525|delta/epsilon subdivisions,2WJEG@28221|Deltaproteobacteria,2YUPX@29|Myxococcales	28221|Deltaproteobacteria	E	Asparagine synthase	asnB	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
HKD2_k127_5964314_0	1297570.MESS4_620013	1.778e-211	687.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2TRP2@28211|Alphaproteobacteria,43IDX@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	IQ	AMP-binding enzyme	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
HKD2_k127_5964314_3	404589.Anae109_1208	5.384e-18	93.0	COG0236@1|root,COG0236@2|Bacteria,1NC80@1224|Proteobacteria,42VU0@68525|delta/epsilon subdivisions,2WRU6@28221|Deltaproteobacteria,2Z2NF@29|Myxococcales	28221|Deltaproteobacteria	IQ	Phosphopantetheine attachment site	-	-	-	-	-	-	-	-	-	-	-	-	PP-binding
HKD2_k127_5964314_2	448385.sce1626	4.34e-101	338.0	COG1543@1|root,COG1543@2|Bacteria,1R5SN@1224|Proteobacteria,42PSX@68525|delta/epsilon subdivisions,2WU5G@28221|Deltaproteobacteria,2YTTH@29|Myxococcales	28221|Deltaproteobacteria	G	Belongs to the glycosyl hydrolase 57 family	-	-	2.4.1.18	ko:K16149	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000	-	GH57	-	DUF1957,Glyco_hydro_57
HKD2_k127_5970471_4	1254432.SCE1572_38140	2.698e-17	82.0	COG1995@1|root,COG1995@2|Bacteria,1MX5W@1224|Proteobacteria,42NJJ@68525|delta/epsilon subdivisions,2WJGI@28221|Deltaproteobacteria,2YV17@29|Myxococcales	28221|Deltaproteobacteria	C	Belongs to the PdxA family	pdxA	-	1.1.1.262,1.1.1.408,1.1.1.409	ko:K00097,ko:K22024	ko00750,ko01100,map00750,map01100	M00124	R05681,R05837,R07406	RC00089,RC00675,RC01475	ko00000,ko00001,ko00002,ko01000	-	-	-	PdxA
HKD2_k127_5970471_3	1192034.CAP_3406	2.669e-29	127.0	COG0705@1|root,COG0705@2|Bacteria	2|Bacteria	S	proteolysis	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
HKD2_k127_5970471_1	243231.GSU0028	3.354e-47	178.0	COG0811@1|root,COG0811@2|Bacteria,1NCWW@1224|Proteobacteria,42PKF@68525|delta/epsilon subdivisions,2WNQ4@28221|Deltaproteobacteria,43UJY@69541|Desulfuromonadales	28221|Deltaproteobacteria	U	PFAM MotA TolQ ExbB proton channel	aglX	-	-	ko:K03562	ko01120,map01120	-	-	-	ko00000,ko02000	1.A.30.2.2	-	-	MotA_ExbB
HKD2_k127_5970471_2	1254432.SCE1572_04395	1.428e-37	145.0	COG0848@1|root,COG0848@2|Bacteria,1MZ6M@1224|Proteobacteria,42U00@68525|delta/epsilon subdivisions,2WQD4@28221|Deltaproteobacteria,2YVFC@29|Myxococcales	28221|Deltaproteobacteria	U	Biopolymer transport protein ExbD/TolR	tolR	-	-	ko:K03560	-	-	-	-	ko00000,ko02000	1.A.30.2.2	-	-	ExbD
HKD2_k127_5970471_0	502025.Hoch_0133	3.198e-60	225.0	COG0823@1|root,COG0823@2|Bacteria,1MV09@1224|Proteobacteria,42PHP@68525|delta/epsilon subdivisions,2WIXN@28221|Deltaproteobacteria,2YVNE@29|Myxococcales	28221|Deltaproteobacteria	U	Involved in the TonB-independent uptake of proteins	tolB	GO:0003674,GO:0005215,GO:0006810,GO:0008150,GO:0019534,GO:0022857,GO:0051179,GO:0051234,GO:0055085,GO:1901998	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40,TolB_N
HKD2_k127_5987572_5	448385.sce3651	1.225e-25	113.0	COG4260@1|root,COG4260@2|Bacteria,1MXTD@1224|Proteobacteria,42P7D@68525|delta/epsilon subdivisions,2WJ6S@28221|Deltaproteobacteria,2YUUH@29|Myxococcales	28221|Deltaproteobacteria	S	SPFH domain-Band 7 family	-	-	-	-	-	-	-	-	-	-	-	-	Band_7_1,DUF4339,DZR,SHOCT,zinc_ribbon_2
HKD2_k127_5987572_7	1242864.D187_000186	1.487e-06	57.0	COG1040@1|root,COG1040@2|Bacteria,1N668@1224|Proteobacteria,430SZ@68525|delta/epsilon subdivisions,2WVMF@28221|Deltaproteobacteria,2YZ96@29|Myxococcales	28221|Deltaproteobacteria	S	zinc-ribbon domain	-	-	-	-	-	-	-	-	-	-	-	-	DZR
HKD2_k127_5987572_2	1254432.SCE1572_22030	1.3e-98	338.0	COG0515@1|root,COG0745@1|root,COG3266@1|root,COG0515@2|Bacteria,COG0745@2|Bacteria,COG3266@2|Bacteria,1NVZF@1224|Proteobacteria,42ZUK@68525|delta/epsilon subdivisions,2X7NR@28221|Deltaproteobacteria,2Z3H7@29|Myxococcales	28221|Deltaproteobacteria	T	Domain of unknown function (DUF4388)	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	DUF4388,Response_reg
HKD2_k127_5987572_0	1192034.CAP_6829	2.235e-149	502.0	COG0745@1|root,COG0745@2|Bacteria,1NVZF@1224|Proteobacteria,42ZUK@68525|delta/epsilon subdivisions,2X7NR@28221|Deltaproteobacteria,2Z3H7@29|Myxococcales	28221|Deltaproteobacteria	T	Domain of unknown function (DUF4388)	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	DUF4388,Response_reg
HKD2_k127_5987572_3	1192034.CAP_6828	4.676e-91	311.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,42P18@68525|delta/epsilon subdivisions,2WKFV@28221|Deltaproteobacteria,2YUS4@29|Myxococcales	28221|Deltaproteobacteria	U	Binding-protein-dependent transport system inner membrane component	dppB	-	-	ko:K02033,ko:K12369,ko:K13890	ko02010,ko02024,map02010,map02024	M00239,M00324,M00348	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.11	-	-	BPD_transp_1
HKD2_k127_5987572_1	448385.sce3647	6.113e-127	426.0	COG1173@1|root,COG4166@1|root,COG1173@2|Bacteria,COG4166@2|Bacteria,1MU26@1224|Proteobacteria,42MFP@68525|delta/epsilon subdivisions,2WJ47@28221|Deltaproteobacteria,2YV85@29|Myxococcales	28221|Deltaproteobacteria	EP	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02034,ko:K15582	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	BPD_transp_1,OppC_N,SBP_bac_5
HKD2_k127_5987572_4	448385.sce3647	1.628e-70	256.0	COG1173@1|root,COG4166@1|root,COG1173@2|Bacteria,COG4166@2|Bacteria,1MU26@1224|Proteobacteria,42MFP@68525|delta/epsilon subdivisions,2WJ47@28221|Deltaproteobacteria,2YV85@29|Myxococcales	28221|Deltaproteobacteria	EP	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02034,ko:K15582	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	BPD_transp_1,OppC_N,SBP_bac_5
HKD2_k127_5987572_6	1033730.CAHG01000006_gene1125	9.038e-16	89.0	COG2267@1|root,COG2267@2|Bacteria,2GJ78@201174|Actinobacteria,4DREB@85009|Propionibacteriales	201174|Actinobacteria	I	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
HKD2_k127_6007_2	448385.sce9222	1.024e-17	83.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2YUJU@29|Myxococcales	28221|Deltaproteobacteria	T	response regulator	-	-	-	ko:K07713	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD2_k127_6007_1	448385.sce9221	1.259e-83	287.0	COG3031@1|root,COG3031@2|Bacteria,1RFDB@1224|Proteobacteria,42WP0@68525|delta/epsilon subdivisions,2X6P7@28221|Deltaproteobacteria,2Z3BZ@29|Myxococcales	28221|Deltaproteobacteria	U	General secretion pathway protein C	-	-	-	ko:K02452	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSC
HKD2_k127_6007_0	1254432.SCE1572_52000	4.251e-209	674.0	COG1450@1|root,COG4796@1|root,COG1450@2|Bacteria,COG4796@2|Bacteria,1MUUA@1224|Proteobacteria,42M9I@68525|delta/epsilon subdivisions,2WK1H@28221|Deltaproteobacteria,2YUDZ@29|Myxococcales	28221|Deltaproteobacteria	NU	Type II and III secretion system protein	gspD	-	-	ko:K02453	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	Secretin,Secretin_N
HKD2_k127_6059635_2	502025.Hoch_6646	2.815e-51	191.0	COG4402@1|root,COG4402@2|Bacteria,1MVMM@1224|Proteobacteria	1224|Proteobacteria	M	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF2330
HKD2_k127_6059635_0	502025.Hoch_6646	1.569e-177	570.0	COG4402@1|root,COG4402@2|Bacteria,1MVMM@1224|Proteobacteria	1224|Proteobacteria	M	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF2330
HKD2_k127_6059635_1	391625.PPSIR1_28128	2.231e-64	252.0	COG0457@1|root,COG0457@2|Bacteria,1QZTW@1224|Proteobacteria,43CNX@68525|delta/epsilon subdivisions,2X7W7@28221|Deltaproteobacteria,2Z2GV@29|Myxococcales	28221|Deltaproteobacteria	C	Cytochrome c554 and c-prime	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554
HKD2_k127_6084267_1	448385.sce1269	1.784e-122	402.0	COG0454@1|root,COG3467@1|root,COG0454@2|Bacteria,COG3467@2|Bacteria,1NEP5@1224|Proteobacteria,42TH0@68525|delta/epsilon subdivisions,2X81R@28221|Deltaproteobacteria,2YZCR@29|Myxococcales	28221|Deltaproteobacteria	K	Pyridoxamine 5'-phosphate oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Pyridox_ox_2
HKD2_k127_6084267_0	1254432.SCE1572_08690	1.997e-154	501.0	COG1167@1|root,COG1167@2|Bacteria,1MVGT@1224|Proteobacteria,43AKF@68525|delta/epsilon subdivisions,2X60H@28221|Deltaproteobacteria,2YZ4M@29|Myxococcales	28221|Deltaproteobacteria	K	helix_turn_helix gluconate operon transcriptional repressor	-	-	-	ko:K00375	-	-	-	-	ko00000,ko03000	-	-	-	Aminotran_1_2,GntR
HKD2_k127_6096332_0	404589.Anae109_3844	3.747e-133	439.0	COG0477@1|root,COG0477@2|Bacteria,1MWUR@1224|Proteobacteria,43BPW@68525|delta/epsilon subdivisions,2X5ED@28221|Deltaproteobacteria	28221|Deltaproteobacteria	EGP	Fungal trichothecene efflux pump (TRI12)	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD2_k127_6096332_2	215803.DB30_3246	3.07e-74	281.0	COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,42N16@68525|delta/epsilon subdivisions,2X5GX@28221|Deltaproteobacteria,2YTTV@29|Myxococcales	28221|Deltaproteobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
HKD2_k127_6096332_1	1254432.SCE1572_42215	5.171e-112	385.0	COG2027@1|root,COG2027@2|Bacteria,1MW40@1224|Proteobacteria,42UDC@68525|delta/epsilon subdivisions,2X5AW@28221|Deltaproteobacteria,2Z34Y@29|Myxococcales	28221|Deltaproteobacteria	M	D-alanyl-D-alanine carboxypeptidase	dacB	-	3.4.16.4	ko:K07259	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	Peptidase_S13
HKD2_k127_611088_1	448385.sce0783	5.741e-122	411.0	COG1287@1|root,COG1287@2|Bacteria	2|Bacteria	S	oligosaccharyl transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_611088_3	1192034.CAP_4311	4.326e-80	283.0	COG1716@1|root,COG1716@2|Bacteria,1NEW5@1224|Proteobacteria,42VUF@68525|delta/epsilon subdivisions,2WRV9@28221|Deltaproteobacteria,2YV34@29|Myxococcales	28221|Deltaproteobacteria	T	FHA domain	-	-	-	-	-	-	-	-	-	-	-	-	FHA,TonB_C,Yop-YscD_cpl
HKD2_k127_611088_2	448385.sce0671	2.287e-92	313.0	COG0667@1|root,COG0667@2|Bacteria,1MVEH@1224|Proteobacteria	1224|Proteobacteria	C	Aldo Keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
HKD2_k127_611088_4	448385.sce0670	1.797e-56	226.0	COG1218@1|root,COG1218@2|Bacteria,1N0GY@1224|Proteobacteria,42QY6@68525|delta/epsilon subdivisions,2WN05@28221|Deltaproteobacteria,2YV4R@29|Myxococcales	28221|Deltaproteobacteria	P	Inositol monophosphatase family	cysQ	-	3.1.3.7	ko:K01082	ko00920,ko01100,ko01120,ko01130,map00920,map01100,map01120,map01130	-	R00188,R00508	RC00078	ko00000,ko00001,ko01000,ko03016	-	-	-	Inositol_P
HKD2_k127_611088_0	1192034.CAP_6504	2.486e-123	413.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,430N6@68525|delta/epsilon subdivisions,2WVRE@28221|Deltaproteobacteria,2YUVI@29|Myxococcales	28221|Deltaproteobacteria	KLT	Protein kinase domain	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
HKD2_k127_611088_5	448385.sce4951	3.392e-31	143.0	2ANDU@1|root,31DCF@2|Bacteria,1QAIC@1224|Proteobacteria,43541@68525|delta/epsilon subdivisions,2X956@28221|Deltaproteobacteria,2Z1ZX@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	VCBS
HKD2_k127_6111853_9	1254432.SCE1572_42360	3.697e-34	134.0	COG0781@1|root,COG0781@2|Bacteria,1N94P@1224|Proteobacteria,42SEA@68525|delta/epsilon subdivisions,2WQP9@28221|Deltaproteobacteria,2YVKR@29|Myxococcales	28221|Deltaproteobacteria	K	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons	nusB	-	-	ko:K03625	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	NusB
HKD2_k127_6111853_5	1192034.CAP_2889	1.046e-65	227.0	COG0054@1|root,COG0054@2|Bacteria,1RD9J@1224|Proteobacteria,42RQ6@68525|delta/epsilon subdivisions,2WNCZ@28221|Deltaproteobacteria,2YV53@29|Myxococcales	28221|Deltaproteobacteria	H	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin	ribH	GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.78	ko:K00794	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R04457	RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	DMRL_synthase
HKD2_k127_6111853_1	1192034.CAP_2888	3.878e-166	531.0	COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,1MU8P@1224|Proteobacteria,42N1C@68525|delta/epsilon subdivisions,2WIP5@28221|Deltaproteobacteria,2YUHV@29|Myxococcales	28221|Deltaproteobacteria	H	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate	ribBA	-	3.5.4.25,4.1.99.12	ko:K14652	ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110	M00125,M00840	R00425,R07281	RC00293,RC01792,RC01815,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	-	DHBP_synthase,GTP_cyclohydro2
HKD2_k127_6111853_7	935863.AWZR01000009_gene53	4.665e-58	213.0	COG0307@1|root,COG0307@2|Bacteria,1MUMB@1224|Proteobacteria,1RMSY@1236|Gammaproteobacteria,1X4H0@135614|Xanthomonadales	135614|Xanthomonadales	H	Riboflavin synthase	ribE	-	2.5.1.9	ko:K00793	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00066	RC00958,RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	Lum_binding
HKD2_k127_6111853_8	1192034.CAP_3157	1.266e-34	147.0	COG4105@1|root,COG4105@2|Bacteria	2|Bacteria	S	cell envelope organization	bamD	-	-	ko:K05807,ko:K08309	-	-	-	-	ko00000,ko01000,ko01011,ko02000	1.B.33.1	GH23	-	YfiO
HKD2_k127_6111853_3	448385.sce3393	7.848e-107	362.0	COG0515@1|root,COG0515@2|Bacteria	448385.sce3393|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6111853_6	290397.Adeh_1282	4.123e-65	235.0	COG0221@1|root,COG0221@2|Bacteria,1RA2F@1224|Proteobacteria,42MQB@68525|delta/epsilon subdivisions,2WPIA@28221|Deltaproteobacteria,2Z34C@29|Myxococcales	28221|Deltaproteobacteria	C	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions	ppa	-	3.6.1.1	ko:K01507	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyrophosphatase
HKD2_k127_6111853_2	1254432.SCE1572_00075	7.841e-145	467.0	COG0113@1|root,COG0113@2|Bacteria,1MWMW@1224|Proteobacteria,42N17@68525|delta/epsilon subdivisions,2WJE8@28221|Deltaproteobacteria,2YTTT@29|Myxococcales	28221|Deltaproteobacteria	H	Belongs to the ALAD family	hemB	-	4.2.1.24	ko:K01698	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00036	RC00918,RC01781	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ALAD
HKD2_k127_6111853_4	1254432.SCE1572_12110	4.862e-72	250.0	COG0293@1|root,COG0293@2|Bacteria,1MW1C@1224|Proteobacteria,42T4F@68525|delta/epsilon subdivisions,2WP6B@28221|Deltaproteobacteria,2YVEY@29|Myxococcales	28221|Deltaproteobacteria	J	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit	ftsJ	-	2.1.1.166	ko:K02427	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ
HKD2_k127_6111853_0	1254432.SCE1572_17800	0.0	1247.0	COG0515@1|root,COG3899@1|root,COG0515@2|Bacteria,COG3899@2|Bacteria	2|Bacteria	T	PFAM Protein kinase domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,Pkinase
HKD2_k127_6127346_2	1254432.SCE1572_28445	5.318e-43	171.0	28H8R@1|root,2Z7KJ@2|Bacteria,1Q390@1224|Proteobacteria,43905@68525|delta/epsilon subdivisions,2X457@28221|Deltaproteobacteria,2YYAC@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6127346_5	1254432.SCE1572_10420	1.698e-26	117.0	COG1191@1|root,COG1191@2|Bacteria,1Q2IP@1224|Proteobacteria,4385G@68525|delta/epsilon subdivisions,2X9Y3@28221|Deltaproteobacteria,2YVUY@29|Myxococcales	28221|Deltaproteobacteria	K	Belongs to the sigma-70 factor family	-	-	-	ko:K02405	ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111	-	-	-	ko00000,ko00001,ko02035,ko03021	-	-	-	Sigma70_r2,Sigma70_r4
HKD2_k127_6127346_6	1144275.COCOR_06144	0.0001034	49.0	2BQGY@1|root,32JCG@2|Bacteria,1Q9S5@1224|Proteobacteria,434JV@68525|delta/epsilon subdivisions,2WYX4@28221|Deltaproteobacteria,2Z0UF@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6127346_0	1192034.CAP_4565	3.266e-130	424.0	COG0482@1|root,COG0482@2|Bacteria,1MUT1@1224|Proteobacteria,42MZR@68525|delta/epsilon subdivisions,2WK6B@28221|Deltaproteobacteria,2YUTU@29|Myxococcales	28221|Deltaproteobacteria	J	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34	mnmA	-	2.8.1.13	ko:K00566	ko04122,map04122	-	R08700	RC02313,RC02315	ko00000,ko00001,ko01000,ko03016	-	-	-	tRNA_Me_trans
HKD2_k127_6127346_7	394221.Mmar10_0874	0.0003908	52.0	COG0457@1|root,COG0457@2|Bacteria,1MVCA@1224|Proteobacteria,2UAC1@28211|Alphaproteobacteria,43WT7@69657|Hyphomonadaceae	28211|Alphaproteobacteria	S	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_7,TPR_8
HKD2_k127_6127346_1	1192034.CAP_4568	2.781e-102	339.0	COG0515@1|root,COG0515@2|Bacteria,1Q2R6@1224|Proteobacteria,433VB@68525|delta/epsilon subdivisions,2X3MY@28221|Deltaproteobacteria,2YWK6@29|Myxococcales	28221|Deltaproteobacteria	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HKD2_k127_613056_2	1192034.CAP_7542	8.257e-26	110.0	COG0303@1|root,COG0303@2|Bacteria,1MVD5@1224|Proteobacteria,42MZZ@68525|delta/epsilon subdivisions,2WIQI@28221|Deltaproteobacteria,2YUSK@29|Myxococcales	28221|Deltaproteobacteria	H	MoeA C-terminal region (domain IV)	-	-	2.10.1.1	ko:K03750	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N
HKD2_k127_613056_0	1254432.SCE1572_17250	2.207e-108	369.0	COG2269@1|root,COG2269@2|Bacteria,1MU97@1224|Proteobacteria,42MAN@68525|delta/epsilon subdivisions,2WJBB@28221|Deltaproteobacteria,2YUT5@29|Myxococcales	28221|Deltaproteobacteria	J	tRNA synthetases class II (D, K and N)	genX	-	-	ko:K04568	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	tRNA-synt_2
HKD2_k127_613056_3	215803.DB30_3693	9.981e-06	56.0	COG1987@1|root,COG1987@2|Bacteria,1R357@1224|Proteobacteria,42XBY@68525|delta/epsilon subdivisions,2WR4T@28221|Deltaproteobacteria,2Z14W@29|Myxococcales	28221|Deltaproteobacteria	N	Bacterial export proteins, family 3	fliQ	-	-	ko:K02420	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	Bac_export_3
HKD2_k127_613056_1	1144275.COCOR_07830	1.451e-98	329.0	COG1028@1|root,COG1028@2|Bacteria,1MUBQ@1224|Proteobacteria,42S4I@68525|delta/epsilon subdivisions,2WNXV@28221|Deltaproteobacteria,2YUF1@29|Myxococcales	28221|Deltaproteobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	fabG3	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HKD2_k127_61578_7	1192034.CAP_6727	5.643e-23	100.0	COG1216@1|root,COG1216@2|Bacteria,1QVEM@1224|Proteobacteria,42NYG@68525|delta/epsilon subdivisions,2WIXP@28221|Deltaproteobacteria,2Z1KB@29|Myxococcales	28221|Deltaproteobacteria	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	DUF2062,Glycos_transf_2
HKD2_k127_61578_1	1254432.SCE1572_41060	1.998e-129	433.0	COG3049@1|root,COG3049@2|Bacteria,1RHU2@1224|Proteobacteria,42XVE@68525|delta/epsilon subdivisions,2WT93@28221|Deltaproteobacteria,2YW4E@29|Myxococcales	28221|Deltaproteobacteria	M	Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase	-	-	-	-	-	-	-	-	-	-	-	-	AAT
HKD2_k127_61578_4	448385.sce6992	3.532e-34	142.0	COG2834@1|root,COG2834@2|Bacteria	2|Bacteria	M	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)	lolA	-	-	ko:K03634	-	-	-	-	ko00000	-	-	-	LolA,LolA_like
HKD2_k127_61578_6	1145276.T479_07310	3.957e-23	107.0	COG1670@1|root,COG1670@2|Bacteria,1V3NE@1239|Firmicutes,4HG1N@91061|Bacilli,3IXNR@400634|Lysinibacillus	91061|Bacilli	J	Acetyltransferase (GNAT) domain	-	-	-	ko:K03817	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_3
HKD2_k127_61578_2	1254432.SCE1572_41235	1.302e-95	321.0	COG0614@1|root,COG0614@2|Bacteria,1PK1H@1224|Proteobacteria,433XB@68525|delta/epsilon subdivisions,2X3Z2@28221|Deltaproteobacteria,2YXNE@29|Myxococcales	28221|Deltaproteobacteria	P	Periplasmic binding protein	-	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_2
HKD2_k127_61578_3	1192034.CAP_0881	2.053e-36	151.0	COG1651@1|root,COG1651@2|Bacteria	2|Bacteria	O	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Thioredoxin_4,VKOR
HKD2_k127_61578_0	448385.sce9004	4.975e-220	700.0	COG0557@1|root,COG0557@2|Bacteria,1MUS6@1224|Proteobacteria,42NHP@68525|delta/epsilon subdivisions,2X6U1@28221|Deltaproteobacteria,2Z35Z@29|Myxococcales	28221|Deltaproteobacteria	J	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs	-	-	3.1.13.1	ko:K01147,ko:K12573	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	OB_RNB,RNB,S1
HKD2_k127_6160489_2	1254432.SCE1572_42545	6.994e-18	94.0	COG0633@1|root,COG0633@2|Bacteria	2|Bacteria	C	Ferredoxin	fdxC	-	-	ko:K04755,ko:K11107	-	-	-	-	ko00000	-	-	-	Fer2
HKD2_k127_6160489_0	1210884.HG799469_gene13934	4.638e-113	387.0	COG0863@1|root,COG0863@2|Bacteria,2J4GH@203682|Planctomycetes	203682|Planctomycetes	L	Belongs to the N(4) N(6)-methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6160489_1	1192034.CAP_1210	5.291e-21	94.0	COG2834@1|root,COG2834@2|Bacteria,1PDTV@1224|Proteobacteria,42TAB@68525|delta/epsilon subdivisions,2WPXY@28221|Deltaproteobacteria,2YVS1@29|Myxococcales	28221|Deltaproteobacteria	M	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)	lolA	-	-	ko:K03634	-	-	-	-	ko00000	-	-	-	LolA
HKD2_k127_620158_4	448385.sce7359	9.999e-40	151.0	COG0531@1|root,COG0531@2|Bacteria,1R829@1224|Proteobacteria,42MS5@68525|delta/epsilon subdivisions,2WINQ@28221|Deltaproteobacteria,2YYB3@29|Myxococcales	28221|Deltaproteobacteria	E	Amino acid permease	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
HKD2_k127_620158_1	105425.BBPL01000052_gene5717	3.262e-78	277.0	COG4325@1|root,COG4325@2|Bacteria,2GWFP@201174|Actinobacteria,2NM4U@228398|Streptacidiphilus	201174|Actinobacteria	S	Predicted membrane protein (DUF2254)	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009405,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0051704	-	-	-	-	-	-	-	-	-	-	DUF2254
HKD2_k127_620158_0	1144275.COCOR_07006	1.044e-95	330.0	COG0515@1|root,COG0515@2|Bacteria	1144275.COCOR_07006|-	KLT	protein kinase activity	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	-
HKD2_k127_620158_6	1463885.KL578368_gene998	0.0001171	48.0	COG5660@1|root,COG5660@2|Bacteria,2GQSP@201174|Actinobacteria	201174|Actinobacteria	S	Putative zinc-finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
HKD2_k127_620158_3	404589.Anae109_3622	4.093e-43	164.0	COG1595@1|root,COG1595@2|Bacteria,1RI7C@1224|Proteobacteria,42XJU@68525|delta/epsilon subdivisions,2WT13@28221|Deltaproteobacteria,2Z11E@29|Myxococcales	28221|Deltaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD2_k127_620158_5	1123242.JH636434_gene4294	5.434e-32	133.0	COG0564@1|root,COG0564@2|Bacteria,2IZYH@203682|Planctomycetes	203682|Planctomycetes	J	Pseudouridine synthase	-	-	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2
HKD2_k127_620158_2	448385.sce1735	1.241e-65	229.0	COG3158@1|root,COG3158@2|Bacteria,1MUVH@1224|Proteobacteria,42P5Y@68525|delta/epsilon subdivisions,2WJEH@28221|Deltaproteobacteria,2YXPN@29|Myxococcales	28221|Deltaproteobacteria	P	Transport of potassium into the cell	kup	GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015672,GO:0016020,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0098655,GO:0098660,GO:0098662	-	ko:K03549	-	-	-	-	ko00000,ko02000	2.A.72	-	-	K_trans
HKD2_k127_6306126_1	448385.sce8630	7.335e-67	234.0	COG1473@1|root,COG1473@2|Bacteria,1MX6N@1224|Proteobacteria,42S5J@68525|delta/epsilon subdivisions,2WNJC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Peptidase dimerisation domain	-	-	-	ko:K12941	-	-	-	-	ko00000,ko01002	-	-	-	M20_dimer,Peptidase_M20
HKD2_k127_6306126_0	1254432.SCE1572_11645	8.707e-148	502.0	COG1629@1|root,COG4771@2|Bacteria,1QX4E@1224|Proteobacteria,437VM@68525|delta/epsilon subdivisions,2X358@28221|Deltaproteobacteria,2YUBU@29|Myxococcales	28221|Deltaproteobacteria	P	TonB-dependent Receptor Plug Domain	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_C,TonB_dep_Rec
HKD2_k127_632100_2	1254432.SCE1572_31085	7.564e-95	319.0	COG0013@1|root,COG0013@2|Bacteria,1MU9A@1224|Proteobacteria,42M70@68525|delta/epsilon subdivisions,2WJA8@28221|Deltaproteobacteria,2YU3X@29|Myxococcales	28221|Deltaproteobacteria	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
HKD2_k127_632100_1	357808.RoseRS_0181	7.404e-120	396.0	COG1373@1|root,COG1373@2|Bacteria	2|Bacteria	V	ATPase (AAA superfamily	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14,DUF4143
HKD2_k127_632100_0	518766.Rmar_0086	3.196e-136	451.0	COG0667@1|root,COG0667@2|Bacteria,4NEDK@976|Bacteroidetes,1FJJ9@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
HKD2_k127_632100_3	1192034.CAP_2209	1.292e-93	312.0	COG0541@1|root,COG0541@2|Bacteria,1MVIA@1224|Proteobacteria,42M94@68525|delta/epsilon subdivisions,2WINB@28221|Deltaproteobacteria,2YUHB@29|Myxococcales	28221|Deltaproteobacteria	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components	ffh	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
HKD2_k127_633362_2	448385.sce2586	5.28e-55	197.0	COG0590@1|root,COG0590@2|Bacteria,1RGU0@1224|Proteobacteria,42TVP@68525|delta/epsilon subdivisions,2WQ7U@28221|Deltaproteobacteria,2YVEI@29|Myxococcales	28221|Deltaproteobacteria	F	Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)	tadA	-	3.5.4.33	ko:K11991	-	-	R10223	RC00477	ko00000,ko01000,ko03016	-	-	-	MafB19-deam
HKD2_k127_633362_6	1254432.SCE1572_18200	3.704e-19	102.0	COG0848@1|root,COG0848@2|Bacteria,1N8FU@1224|Proteobacteria,42WU3@68525|delta/epsilon subdivisions,2WSMD@28221|Deltaproteobacteria,2YZRG@29|Myxococcales	28221|Deltaproteobacteria	U	Biopolymer transport protein ExbD/TolR	-	-	-	-	-	-	-	-	-	-	-	-	ExbD
HKD2_k127_633362_4	1267535.KB906767_gene2778	1.195e-50	186.0	COG1595@1|root,COG1595@2|Bacteria,3Y7S5@57723|Acidobacteria,2JMWY@204432|Acidobacteriia	204432|Acidobacteriia	K	Sigma-70, region 4	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD2_k127_633362_7	977880.RALTA_B1994	5.214e-12	78.0	COG3258@1|root,COG3258@2|Bacteria,1QTYW@1224|Proteobacteria,2VRNU@28216|Betaproteobacteria,1KG4I@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	ko:K08738	ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	3.D.4.6	-	-	Cytochrom_C,Cytochrome_CBB3
HKD2_k127_633362_3	391626.OAN307_c45030	3.074e-52	210.0	COG1196@1|root,COG1196@2|Bacteria,1NMFV@1224|Proteobacteria,2U3RD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	D	nuclear chromosome segregation	-	-	-	-	-	-	-	-	-	-	-	-	AAA_23,SMC_N
HKD2_k127_633362_0	1254432.SCE1572_15505	1.005e-117	407.0	COG0744@1|root,COG0744@2|Bacteria,1RDAQ@1224|Proteobacteria,42QW6@68525|delta/epsilon subdivisions,2WPZA@28221|Deltaproteobacteria,2YVC6@29|Myxococcales	28221|Deltaproteobacteria	M	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors	mtgA	-	2.4.1.129	ko:K03814	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly
HKD2_k127_633362_5	448385.sce8244	1.081e-31	133.0	COG2453@1|root,COG2453@2|Bacteria,1QSUD@1224|Proteobacteria,43A8J@68525|delta/epsilon subdivisions,2X3DG@28221|Deltaproteobacteria,2YVJ1@29|Myxococcales	28221|Deltaproteobacteria	T	Dual specificity phosphatase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	DSPc
HKD2_k127_6353800_1	1192034.CAP_1210	4.075e-44	168.0	COG2834@1|root,COG2834@2|Bacteria,1PDTV@1224|Proteobacteria,42TAB@68525|delta/epsilon subdivisions,2WPXY@28221|Deltaproteobacteria,2YVS1@29|Myxococcales	28221|Deltaproteobacteria	M	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)	lolA	-	-	ko:K03634	-	-	-	-	ko00000	-	-	-	LolA
HKD2_k127_6353800_2	1254432.SCE1572_30840	8.843e-41	157.0	COG0817@1|root,COG0817@2|Bacteria,1MUJI@1224|Proteobacteria,42QPX@68525|delta/epsilon subdivisions,2WNF9@28221|Deltaproteobacteria,2YVCN@29|Myxococcales	28221|Deltaproteobacteria	L	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group	ruvC	GO:0000725,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008821,GO:0009058,GO:0009059,GO:0009987,GO:0016787,GO:0016788,GO:0016889,GO:0016894,GO:0031297,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0045005,GO:0046483,GO:0048476,GO:0050896,GO:0051716,GO:0071704,GO:0071932,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901576	3.1.22.4	ko:K01159	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvC
HKD2_k127_6353800_0	448385.sce7391	1.624e-112	367.0	COG0217@1|root,COG0217@2|Bacteria,1MW3X@1224|Proteobacteria,42N7Q@68525|delta/epsilon subdivisions,2WJ1I@28221|Deltaproteobacteria,2YUPW@29|Myxococcales	28221|Deltaproteobacteria	K	transcriptional regulatory protein	yebC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	-	-	-	-	-	-	-	-	-	Transcrip_reg
HKD2_k127_6353800_3	1192034.CAP_6082	7.111e-05	51.0	COG2979@1|root,COG2979@2|Bacteria	2|Bacteria	T	Protein of unknown function (DUF533)	-	-	-	ko:K06596	ko02020,ko02025,map02020,map02025	M00507	-	-	ko00000,ko00001,ko00002,ko01001,ko02022,ko02035	-	-	-	DUF533,PG_binding_4,TerB,VanW
HKD2_k127_635643_1	448385.sce2877	1.97e-31	126.0	COG4826@1|root,COG4826@2|Bacteria,1REGX@1224|Proteobacteria,42T9N@68525|delta/epsilon subdivisions,2WPDB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	Belongs to the serpin family	-	-	-	ko:K13963	ko05146,map05146	-	-	-	ko00000,ko00001	-	-	-	Serpin
HKD2_k127_635643_0	1448389.BAVQ01000090_gene2088	1.327e-113	391.0	COG1680@1|root,COG1680@2|Bacteria,2GJJB@201174|Actinobacteria	201174|Actinobacteria	V	COG1680 Beta-lactamase class C and other penicillin binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
HKD2_k127_635643_2	1254432.SCE1572_00040	2.808e-29	130.0	COG3921@1|root,COG3921@2|Bacteria	2|Bacteria	S	Extensin-like protein C-terminus	-	-	-	-	-	-	-	-	-	-	-	-	Extensin-like_C
HKD2_k127_635643_3	391625.PPSIR1_12533	7.581e-27	116.0	COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,42ZCI@68525|delta/epsilon subdivisions,2X7VD@28221|Deltaproteobacteria,2YZNM@29|Myxococcales	28221|Deltaproteobacteria	H	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.55	ko:K15372	ko00410,ko00430,ko01100,map00410,map00430,map01100	-	R00908,R01684	RC00006,RC00062	ko00000,ko00001,ko01000	-	-	-	Aminotran_3
HKD2_k127_6383542_1	215803.DB30_8472	4.479e-26	113.0	COG0727@1|root,COG0727@2|Bacteria,1Q3VM@1224|Proteobacteria,4343F@68525|delta/epsilon subdivisions,2X51G@28221|Deltaproteobacteria,2YZZC@29|Myxococcales	28221|Deltaproteobacteria	S	PFAM Uncharacterised protein family (UPF0153)	-	-	-	-	-	-	-	-	-	-	-	-	CxxCxxCC
HKD2_k127_6383542_0	378806.STAUR_6512	9.927e-55	214.0	COG3119@1|root,COG3119@2|Bacteria,1MV0B@1224|Proteobacteria,43AH9@68525|delta/epsilon subdivisions,2X5XB@28221|Deltaproteobacteria,2Z37F@29|Myxococcales	28221|Deltaproteobacteria	P	Type I phosphodiesterase / nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
HKD2_k127_6387391_6	448385.sce0519	1.758e-17	88.0	COG3391@1|root,COG3591@1|root,COG3391@2|Bacteria,COG3591@2|Bacteria,1R0BE@1224|Proteobacteria,43CTP@68525|delta/epsilon subdivisions,2X817@28221|Deltaproteobacteria,2Z05E@29|Myxococcales	28221|Deltaproteobacteria	E	Stigma-specific protein, Stig1	-	-	-	-	-	-	-	-	-	-	-	-	Stig1
HKD2_k127_6387391_3	1254432.SCE1572_45780	7.135e-68	249.0	COG4942@1|root,COG4942@2|Bacteria,1MY3E@1224|Proteobacteria,42N32@68525|delta/epsilon subdivisions,2WKBN@28221|Deltaproteobacteria,2YVR8@29|Myxococcales	28221|Deltaproteobacteria	D	Peptidase family M23	-	-	-	ko:K21471	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_M23,SH3_3
HKD2_k127_6387391_1	1254432.SCE1572_45775	8.23e-95	319.0	COG2177@1|root,COG2177@2|Bacteria,1MU65@1224|Proteobacteria,43BBA@68525|delta/epsilon subdivisions,2X6QG@28221|Deltaproteobacteria,2YVCX@29|Myxococcales	28221|Deltaproteobacteria	D	Part of the ABC transporter FtsEX involved in cellular division	ftsX	-	-	ko:K09811	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	FtsX
HKD2_k127_6387391_0	448385.sce7972	1.702e-111	379.0	COG2884@1|root,COG2884@2|Bacteria,1MVQ4@1224|Proteobacteria,42MAM@68525|delta/epsilon subdivisions,2WK4Y@28221|Deltaproteobacteria,2YV0E@29|Myxococcales	28221|Deltaproteobacteria	D	ABC transporter	ftsE	-	-	ko:K09812	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	ABC_tran
HKD2_k127_6387391_4	502025.Hoch_6113	2.168e-28	129.0	COG2304@1|root,COG2304@2|Bacteria,1MUTS@1224|Proteobacteria,42R8X@68525|delta/epsilon subdivisions,2WN6U@28221|Deltaproteobacteria,2YWMS@29|Myxococcales	28221|Deltaproteobacteria	S	protein containing a von Willebrand factor type A (vWA) domain	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VWA
HKD2_k127_6387391_5	180281.CPCC7001_364	1.509e-22	109.0	COG0673@1|root,COG0673@2|Bacteria,1G2V2@1117|Cyanobacteria,22SJC@167375|Cyanobium	1117|Cyanobacteria	S	Oxidoreductase family, NAD-binding Rossmann fold	mviM	-	-	ko:K03810	-	-	-	-	ko00000	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
HKD2_k127_6387391_2	1183438.GKIL_0576	4.331e-68	239.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria	2|Bacteria	E	serine-type peptidase activity	dpp4	-	3.4.14.5	ko:K01278	ko04974,map04974	-	-	-	ko00000,ko00001,ko01000,ko01002,ko04090,ko04147	-	-	-	DPPIV_N,PD40,Peptidase_S9
HKD2_k127_6389464_0	1192034.CAP_7781	3.174e-80	276.0	COG0631@1|root,COG0631@2|Bacteria,1R7UF@1224|Proteobacteria,42QUA@68525|delta/epsilon subdivisions,2WMWM@28221|Deltaproteobacteria,2YU7P@29|Myxococcales	28221|Deltaproteobacteria	T	Protein serine threonine phosphatase	-	-	3.1.3.16	ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C_2
HKD2_k127_6389464_1	234267.Acid_0054	1.122e-70	245.0	COG0586@1|root,COG0586@2|Bacteria,3Y364@57723|Acidobacteria	57723|Acidobacteria	S	PFAM SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
HKD2_k127_6389464_2	448385.sce7549	9.123e-36	138.0	COG1884@1|root,COG1884@2|Bacteria,1MUXX@1224|Proteobacteria,42P03@68525|delta/epsilon subdivisions,2WIPY@28221|Deltaproteobacteria,2YU4T@29|Myxococcales	28221|Deltaproteobacteria	I	Methylmalonyl-CoA mutase	-	-	5.4.99.2	ko:K01848	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	MM_CoA_mutase
HKD2_k127_6393344_1	1254432.SCE1572_15985	6.116e-49	183.0	COG0784@1|root,COG5002@1|root,COG0784@2|Bacteria,COG5002@2|Bacteria,1NC9X@1224|Proteobacteria	1224|Proteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg
HKD2_k127_6393344_0	448385.sce4512	3.665e-88	311.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,42MVV@68525|delta/epsilon subdivisions,2X4JB@28221|Deltaproteobacteria,2YZ4I@29|Myxococcales	28221|Deltaproteobacteria	KLT	Family membership	-	-	2.7.11.1	ko:K08884	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HKD2_k127_6393344_3	1192034.CAP_2668	8.655e-42	176.0	COG1470@1|root,COG1470@2|Bacteria,1QZIJ@1224|Proteobacteria,43CK1@68525|delta/epsilon subdivisions,2X7UG@28221|Deltaproteobacteria,2YY6W@29|Myxococcales	28221|Deltaproteobacteria	S	PEGA domain	-	-	-	-	-	-	-	-	-	-	-	-	PEGA
HKD2_k127_6393344_2	156889.Mmc1_2003	5.006e-42	174.0	COG0790@1|root,COG0790@2|Bacteria,1MWPA@1224|Proteobacteria,2TR2B@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Sel1 domain protein repeat-containing protein	-	-	-	ko:K07126	-	-	-	-	ko00000	-	-	-	Sel1
HKD2_k127_6393344_4	204773.HEAR1081	7.437e-29	124.0	COG3548@1|root,COG3548@2|Bacteria,1R9WQ@1224|Proteobacteria,2VQBM@28216|Betaproteobacteria,474I0@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Protein of unknown function (DUF1211)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1211
HKD2_k127_6394265_2	1192034.CAP_2601	0.000488	48.0	COG1028@1|root,COG2030@1|root,COG1028@2|Bacteria,COG2030@2|Bacteria,1MXNQ@1224|Proteobacteria,42Q8V@68525|delta/epsilon subdivisions,2WJP0@28221|Deltaproteobacteria,2YZGE@29|Myxococcales	28221|Deltaproteobacteria	IQ	SCP-2 sterol transfer family	-	-	-	-	-	-	-	-	-	-	-	-	ACP_syn_III_C,DUF35_N,MaoC_dehydrat_N,MaoC_dehydratas,OB_aCoA_assoc,SCP2,adh_short
HKD2_k127_6394265_1	391625.PPSIR1_15030	1.245e-51	205.0	COG3118@1|root,COG3118@2|Bacteria	2|Bacteria	O	belongs to the thioredoxin family	-	-	-	ko:K20543	-	-	-	-	ko00000,ko02000	1.B.55.3	-	-	Arylsulfotran_2,UnbV_ASPIC,VCBS
HKD2_k127_6394265_0	1192034.CAP_0547	2.064e-127	421.0	COG1075@1|root,COG1075@2|Bacteria,1R88U@1224|Proteobacteria,4389A@68525|delta/epsilon subdivisions,2XA37@28221|Deltaproteobacteria,2YW9M@29|Myxococcales	28221|Deltaproteobacteria	S	PGAP1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	PGAP1
HKD2_k127_6399943_4	861299.J421_1204	1.168e-63	231.0	COG0312@1|root,COG0312@2|Bacteria	2|Bacteria	S	metallopeptidase activity	tldD	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
HKD2_k127_6399943_7	1254432.SCE1572_26025	1.532e-21	98.0	COG4539@1|root,COG4539@2|Bacteria,1NXWT@1224|Proteobacteria,4384M@68525|delta/epsilon subdivisions,2X9XD@28221|Deltaproteobacteria,2YVQP@29|Myxococcales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF962)	-	-	-	-	-	-	-	-	-	-	-	-	DUF962
HKD2_k127_6399943_6	857087.Metme_4565	3.37e-30	129.0	2E4SK@1|root,32ZM1@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6399943_2	1192034.CAP_8845	3.726e-218	717.0	COG4775@1|root,COG4775@2|Bacteria,1RJPJ@1224|Proteobacteria,42TA2@68525|delta/epsilon subdivisions,2WP1H@28221|Deltaproteobacteria,2YZDW@29|Myxococcales	28221|Deltaproteobacteria	M	Surface antigen	-	-	-	-	-	-	-	-	-	-	-	-	Bac_surface_Ag,POTRA
HKD2_k127_6399943_0	448385.sce1107	2.588e-278	908.0	COG2911@1|root,COG2982@1|root,COG2911@2|Bacteria,COG2982@2|Bacteria,1PQTA@1224|Proteobacteria,42PYT@68525|delta/epsilon subdivisions,2WIZ6@28221|Deltaproteobacteria,2YVF0@29|Myxococcales	28221|Deltaproteobacteria	M	TamB, inner membrane protein subunit of TAM complex	-	-	-	ko:K09800	-	-	-	-	ko00000,ko02000	-	-	-	TamB
HKD2_k127_6399943_3	1254432.SCE1572_02840	5.289e-72	250.0	COG0566@1|root,COG0566@2|Bacteria,1MWBE@1224|Proteobacteria,42R8D@68525|delta/epsilon subdivisions,2WN83@28221|Deltaproteobacteria,2YVI3@29|Myxococcales	28221|Deltaproteobacteria	J	SpoU rRNA Methylase family	trmH	-	2.1.1.34	ko:K00556	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	SpoU_methylase
HKD2_k127_6399943_5	1254432.SCE1572_00020	2.978e-52	190.0	COG0576@1|root,COG0576@2|Bacteria,1RH8T@1224|Proteobacteria,42TM2@68525|delta/epsilon subdivisions,2WQ0U@28221|Deltaproteobacteria,2YVHI@29|Myxococcales	28221|Deltaproteobacteria	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	grpE	GO:0000166,GO:0000774,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0017076,GO:0030234,GO:0030554,GO:0036094,GO:0044424,GO:0044444,GO:0044464,GO:0050790,GO:0051082,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0097159,GO:0098772,GO:1901265,GO:1901363	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
HKD2_k127_6399943_1	1254432.SCE1572_00015	2.95e-273	850.0	COG0443@1|root,COG0443@2|Bacteria,1MVEN@1224|Proteobacteria,42M64@68525|delta/epsilon subdivisions,2WIWS@28221|Deltaproteobacteria,2YU6B@29|Myxococcales	28221|Deltaproteobacteria	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
HKD2_k127_6419036_0	1254432.SCE1572_03155	4.407e-125	412.0	COG0455@1|root,COG0484@1|root,COG1426@1|root,COG0455@2|Bacteria,COG0484@2|Bacteria,COG1426@2|Bacteria,1R8IW@1224|Proteobacteria,42R3H@68525|delta/epsilon subdivisions,2WMNY@28221|Deltaproteobacteria,2YUZU@29|Myxococcales	28221|Deltaproteobacteria	D	NUBPL iron-transfer P-loop NTPase	-	-	-	ko:K04562	-	-	-	-	ko00000,ko02035	-	-	-	AAA_31,CbiA,HTH_25,ParA
HKD2_k127_6419036_1	1254432.SCE1572_03150	5.855e-26	119.0	COG1807@1|root,COG1807@2|Bacteria,1RJ20@1224|Proteobacteria	1224|Proteobacteria	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HKD2_k127_6419192_4	1254432.SCE1572_18040	2.808e-67	231.0	COG0499@1|root,COG0499@2|Bacteria,1MUQ2@1224|Proteobacteria,42M83@68525|delta/epsilon subdivisions,2WIZE@28221|Deltaproteobacteria,2YU8Q@29|Myxococcales	28221|Deltaproteobacteria	H	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine	ahcY	GO:0000096,GO:0003674,GO:0003824,GO:0004013,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009069,GO:0009116,GO:0009119,GO:0009987,GO:0016787,GO:0016801,GO:0016802,GO:0017144,GO:0019752,GO:0033353,GO:0034641,GO:0042278,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901605,GO:1901657	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
HKD2_k127_6419192_3	1254432.SCE1572_18045	1.412e-92	314.0	COG0500@1|root,COG0640@1|root,COG0640@2|Bacteria,COG2226@2|Bacteria,1NFSV@1224|Proteobacteria	1224|Proteobacteria	KQ	TRANSCRIPTIONal	-	-	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	HTH_20,HTH_5,Methyltransf_11,Methyltransf_23,Methyltransf_31
HKD2_k127_6419192_1	448385.sce0950	5.954e-136	456.0	COG3119@1|root,COG3119@2|Bacteria,1QZST@1224|Proteobacteria,43CMS@68525|delta/epsilon subdivisions,2X7UX@28221|Deltaproteobacteria,2Z29A@29|Myxococcales	28221|Deltaproteobacteria	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
HKD2_k127_6419192_2	639030.JHVA01000001_gene519	3.598e-101	340.0	COG0580@1|root,COG0580@2|Bacteria,3Y3SK@57723|Acidobacteria,2JHX3@204432|Acidobacteriia	204432|Acidobacteriia	G	Major intrinsic protein	-	-	-	ko:K06188	-	-	-	-	ko00000,ko02000	1.A.8	-	-	MIP
HKD2_k127_6419192_5	502025.Hoch_1562	3.845e-06	55.0	COG2385@1|root,COG2385@2|Bacteria,1QX7Y@1224|Proteobacteria,43C11@68525|delta/epsilon subdivisions,2X7BP@28221|Deltaproteobacteria,2Z3F4@29|Myxococcales	28221|Deltaproteobacteria	D	sporulation resulting in formation of a cellular spore	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6419192_0	448385.sce9355	1.558e-182	632.0	COG0457@1|root,COG3266@1|root,COG0457@2|Bacteria,COG3266@2|Bacteria,1Q2SX@1224|Proteobacteria,438EQ@68525|delta/epsilon subdivisions,2X3PN@28221|Deltaproteobacteria,2YWSJ@29|Myxococcales	28221|Deltaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_6,TPR_7,TPR_8
HKD2_k127_6419320_0	448385.sce8012	2.044e-249	790.0	COG0204@1|root,COG1022@1|root,COG3320@1|root,COG0204@2|Bacteria,COG1022@2|Bacteria,COG3320@2|Bacteria,1MU4D@1224|Proteobacteria,42NHQ@68525|delta/epsilon subdivisions,2WJZ5@28221|Deltaproteobacteria,2YU6Q@29|Myxococcales	28221|Deltaproteobacteria	IQ	Male sterility protein	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C,Acyltransferase,NAD_binding_4,PP-binding,Sterile
HKD2_k127_6421014_0	926550.CLDAP_24600	2.233e-146	481.0	COG0664@1|root,COG0664@2|Bacteria,2G63K@200795|Chloroflexi	200795|Chloroflexi	T	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6421542_5	1254432.SCE1572_20885	1.765e-38	155.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	hrpL	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD2_k127_6421542_0	1144342.PMI40_01760	7.379e-202	657.0	COG1012@1|root,COG1012@2|Bacteria,1QWN5@1224|Proteobacteria,2WH7P@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Aldehyde dehydrogenase family	-	-	1.2.1.88	ko:K00294	ko00250,ko00330,ko01100,map00250,map00330,map01100	-	R00245,R00707,R00708,R04444,R04445,R05051	RC00080,RC00216,RC00242,RC00255	ko00000,ko00001,ko01000	-	-	-	Aldedh
HKD2_k127_6421542_3	1254432.SCE1572_26335	7.892e-62	229.0	2ANEP@1|root,31DDB@2|Bacteria,1QAJQ@1224|Proteobacteria,434DJ@68525|delta/epsilon subdivisions,2X8U1@28221|Deltaproteobacteria,2Z0DK@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6421542_1	1242864.D187_005362	5.485e-117	391.0	COG3919@1|root,COG3919@2|Bacteria,1N13P@1224|Proteobacteria	1224|Proteobacteria	S	ATP-grasp	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_3,CPSase_L_D2
HKD2_k127_6421542_4	215803.DB30_4681	1.302e-49	189.0	COG1595@1|root,COG1595@2|Bacteria,1Q3A4@1224|Proteobacteria,4391A@68525|delta/epsilon subdivisions,2X46P@28221|Deltaproteobacteria,2YYD1@29|Myxococcales	28221|Deltaproteobacteria	K	Sigma-70, region 4	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r4
HKD2_k127_6421542_2	448385.sce2512	5.1e-81	278.0	COG0842@1|root,COG1131@1|root,COG1716@1|root,COG0842@2|Bacteria,COG1131@2|Bacteria,COG1716@2|Bacteria,1MX27@1224|Proteobacteria	1224|Proteobacteria	TV	ABC-type multidrug transport system ATPase component	-	-	-	ko:K21397	-	-	-	-	ko00000,ko02000	3.A.1	-	-	ABC2_membrane,ABC_tran,FHA
HKD2_k127_6429996_2	1392498.JQLH01000001_gene1011	9.89e-16	91.0	COG3202@1|root,COG3202@2|Bacteria,4NIB2@976|Bacteroidetes,1HWNK@117743|Flavobacteriia,2PI1V@252356|Maribacter	976|Bacteroidetes	C	TLC ATP/ADP transporter	-	-	-	ko:K03301	-	-	-	-	ko00000	2.A.12	-	-	TLC,cNMP_binding
HKD2_k127_6429996_0	1254432.SCE1572_28640	3.846e-112	376.0	COG1694@1|root,COG3956@2|Bacteria,1MVKM@1224|Proteobacteria,42R48@68525|delta/epsilon subdivisions,2WMAR@28221|Deltaproteobacteria,2YUR9@29|Myxococcales	28221|Deltaproteobacteria	E	MazG nucleotide pyrophosphohydrolase domain	mazG	-	3.6.1.9	ko:K02499,ko:K04765	ko00230,ko00240,ko00760,ko00770,ko01100,map00230,map00240,map00760,map00770,map01100	-	R00086,R00087,R00103,R00287,R00426,R00515,R00662,R00720,R03004,R03036,R11323	RC00002	ko00000,ko00001,ko01000,ko03036	-	-	-	MazG
HKD2_k127_6429996_1	290397.Adeh_0453	8.236e-68	242.0	COG0500@1|root,COG0500@2|Bacteria,1R947@1224|Proteobacteria,432GY@68525|delta/epsilon subdivisions,2WYII@28221|Deltaproteobacteria	28221|Deltaproteobacteria	Q	Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6429996_3	1125863.JAFN01000001_gene1946	7.755e-10	71.0	COG0628@1|root,COG0628@2|Bacteria,1MW0B@1224|Proteobacteria,42PVD@68525|delta/epsilon subdivisions,2WN8S@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
HKD2_k127_6430438_2	1192034.CAP_2119	1.425e-43	164.0	COG2353@1|root,COG2353@2|Bacteria,1PBC0@1224|Proteobacteria,43332@68525|delta/epsilon subdivisions,2WX6Z@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	YceI-like domain	-	-	-	-	-	-	-	-	-	-	-	-	YceI
HKD2_k127_6430438_0	1192034.CAP_2117	9.08e-88	305.0	29EP2@1|root,301KY@2|Bacteria,1Q96E@1224|Proteobacteria,437IB@68525|delta/epsilon subdivisions,2X2RW@28221|Deltaproteobacteria,2Z2TH@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6430438_4	595460.RRSWK_07188	4.681e-29	135.0	COG1413@1|root,COG1413@2|Bacteria	2|Bacteria	C	deoxyhypusine monooxygenase activity	-	-	3.4.24.3	ko:K01387	-	-	-	-	ko00000,ko01000,ko01002,ko02042	-	-	-	HEAT_2,Peptidase_M9,Peptidase_M9_N
HKD2_k127_6430438_1	378806.STAUR_3122	1.112e-47	183.0	COG1402@1|root,COG1402@2|Bacteria,1MXR9@1224|Proteobacteria,42QNA@68525|delta/epsilon subdivisions,2WIN0@28221|Deltaproteobacteria,2YW0B@29|Myxococcales	28221|Deltaproteobacteria	S	Creatinine amidohydrolase	-	-	3.5.2.10	ko:K01470	ko00330,map00330	-	R01884	RC00615	ko00000,ko00001,ko01000	-	-	-	Creatininase
HKD2_k127_6430438_3	298386.PBPRB0863	5.368e-42	169.0	COG2010@1|root,COG2010@2|Bacteria,1RCYF@1224|Proteobacteria,1SEBP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Cytochrome c mono- and diheme variants	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,Cytochrome_CBB3
HKD2_k127_6432629_0	1192034.CAP_3457	4.305e-127	434.0	COG2308@1|root,COG2308@2|Bacteria,1Q3RI@1224|Proteobacteria,439JB@68525|delta/epsilon subdivisions,2X4VX@28221|Deltaproteobacteria,2YZQ5@29|Myxococcales	28221|Deltaproteobacteria	S	Evidence 4 Homologs of previously reported genes of	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6432629_1	401053.AciPR4_2142	3.647e-83	287.0	COG0189@1|root,COG0189@2|Bacteria,3Y37D@57723|Acidobacteria,2JI05@204432|Acidobacteriia	204432|Acidobacteriia	HJ	ligase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6432629_2	1123248.KB893336_gene2851	1.808e-13	70.0	COG4947@1|root,COG4947@2|Bacteria,4NJWM@976|Bacteroidetes,1IVCZ@117747|Sphingobacteriia	976|Bacteroidetes	S	Putative esterase	-	-	-	-	-	-	-	-	-	-	-	-	Esterase
HKD2_k127_6433428_1	1192034.CAP_7921	2.132e-37	143.0	COG0404@1|root,COG0404@2|Bacteria,1MV96@1224|Proteobacteria,42QM6@68525|delta/epsilon subdivisions,2WJ8G@28221|Deltaproteobacteria,2Z31K@29|Myxococcales	28221|Deltaproteobacteria	H	The glycine cleavage system catalyzes the degradation of glycine	gcvT	-	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	GCV_T,GCV_T_C
HKD2_k127_6433428_0	1500894.JQNN01000001_gene2871	2.879e-69	239.0	COG2606@1|root,COG2606@2|Bacteria,1RGX5@1224|Proteobacteria,2VQAY@28216|Betaproteobacteria,47416@75682|Oxalobacteraceae	28216|Betaproteobacteria	J	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily	ebsC	-	-	ko:K03976	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_edit
HKD2_k127_6433428_2	1317124.DW2_13855	0.000241	51.0	COG2010@1|root,COG2010@2|Bacteria,1MV6D@1224|Proteobacteria,2TT9U@28211|Alphaproteobacteria,2XNZ8@285107|Thioclava	28211|Alphaproteobacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C
HKD2_k127_6436378_1	448385.sce3997	1.46e-47	177.0	COG0515@1|root,COG0515@2|Bacteria	448385.sce3997|-	KLT	protein kinase activity	-	-	2.7.11.1	ko:K08884	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	-
HKD2_k127_6436378_5	1137269.AZWL01000001_gene5792	4.125e-06	59.0	COG1309@1|root,COG1309@2|Bacteria,2IIFB@201174|Actinobacteria	201174|Actinobacteria	K	BetI-type transcriptional repressor, C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_6,TetR_N
HKD2_k127_6436378_4	1121015.N789_07920	2.485e-09	70.0	2EHT0@1|root,33BIQ@2|Bacteria,1P4FA@1224|Proteobacteria,1SUQ3@1236|Gammaproteobacteria,1X8UR@135614|Xanthomonadales	135614|Xanthomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6436378_2	1157708.KB907456_gene2493	6.131e-35	147.0	COG4339@1|root,COG4339@2|Bacteria,1MZ9X@1224|Proteobacteria,2VRYZ@28216|Betaproteobacteria,4ADYE@80864|Comamonadaceae	28216|Betaproteobacteria	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6436378_3	1254432.SCE1572_10350	1.65e-26	115.0	COG0265@1|root,COG0265@2|Bacteria,1NE6G@1224|Proteobacteria,4321S@68525|delta/epsilon subdivisions,2WWD7@28221|Deltaproteobacteria,2YXPK@29|Myxococcales	28221|Deltaproteobacteria	O	Trypsin-like peptidase domain	-	-	-	-	-	-	-	-	-	-	-	-	Trypsin_2
HKD2_k127_6436378_0	1254432.SCE1572_37300	1.33e-77	265.0	COG0020@1|root,COG0020@2|Bacteria,1MVP1@1224|Proteobacteria,42PTV@68525|delta/epsilon subdivisions,2WMWK@28221|Deltaproteobacteria,2YUTJ@29|Myxococcales	28221|Deltaproteobacteria	H	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids	uppS	GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0071704,GO:1901576,GO:1901615,GO:1901617	2.5.1.31	ko:K00806	ko00900,ko01110,map00900,map01110	-	R06447	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
HKD2_k127_6439159_1	215803.DB30_8893	4.396e-94	320.0	COG0300@1|root,COG0300@2|Bacteria,1R5VP@1224|Proteobacteria,430U9@68525|delta/epsilon subdivisions,2WW0M@28221|Deltaproteobacteria,2YXV8@29|Myxococcales	28221|Deltaproteobacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HKD2_k127_6439159_0	1254432.SCE1572_07645	3.143e-139	447.0	COG3396@1|root,COG3396@2|Bacteria,1MXUK@1224|Proteobacteria,437U1@68525|delta/epsilon subdivisions,2X33K@28221|Deltaproteobacteria,2YU2K@29|Myxococcales	28221|Deltaproteobacteria	S	benzoyl-CoA oxygenase	-	-	1.14.13.208	ko:K15512	ko00362,map00362	-	R09555	RC01739	ko00000,ko00001,ko01000	-	-	-	-
HKD2_k127_6442297_0	378806.STAUR_2950	1.915e-260	815.0	COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,42P3V@68525|delta/epsilon subdivisions,2WKWV@28221|Deltaproteobacteria,2YTVV@29|Myxococcales	28221|Deltaproteobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA1	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
HKD2_k127_6442297_12	1410650.JHWL01000006_gene1488	1.498e-07	64.0	2DP02@1|root,32ZZW@2|Bacteria,1VF4N@1239|Firmicutes,24NKF@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6442297_4	1254432.SCE1572_21130	2.283e-184	589.0	COG2303@1|root,COG2303@2|Bacteria,1MV19@1224|Proteobacteria,42N4C@68525|delta/epsilon subdivisions,2WJIH@28221|Deltaproteobacteria,2YZWU@29|Myxococcales	28221|Deltaproteobacteria	E	GMC oxidoreductase	-	-	1.1.99.1	ko:K00108	ko00260,ko01100,map00260,map01100	M00555	R01025	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	GMC_oxred_C,GMC_oxred_N
HKD2_k127_6442297_3	246197.MXAN_2326	2.651e-205	647.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,42MDU@68525|delta/epsilon subdivisions,2WM9V@28221|Deltaproteobacteria,2YUA1@29|Myxococcales	28221|Deltaproteobacteria	C	Belongs to the aldehyde dehydrogenase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldedh
HKD2_k127_6442297_11	313606.M23134_00497	4.092e-14	82.0	2DFQD@1|root,2ZSNM@2|Bacteria,4P7GE@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6442297_8	404589.Anae109_0505	1.748e-113	374.0	COG0266@1|root,COG0266@2|Bacteria,1MVHK@1224|Proteobacteria,43791@68525|delta/epsilon subdivisions,2X9X0@28221|Deltaproteobacteria,2YZTI@29|Myxococcales	28221|Deltaproteobacteria	L	Belongs to the FPG family	-	-	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
HKD2_k127_6442297_2	378806.STAUR_1657	1.149e-230	727.0	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,42M01@68525|delta/epsilon subdivisions,2WUE6@28221|Deltaproteobacteria,2YTX9@29|Myxococcales	28221|Deltaproteobacteria	V	Efflux ABC transporter, permease ATP-binding protein	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
HKD2_k127_6442297_6	1192034.CAP_2831	1.627e-160	537.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	tagF2	-	2.7.8.12	ko:K09809	-	-	-	-	ko00000,ko01000	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1,Glyphos_transf
HKD2_k127_6442297_1	886293.Sinac_1156	3.134e-243	796.0	COG0515@1|root,COG3899@1|root,COG0515@2|Bacteria,COG3899@2|Bacteria,2J2QS@203682|Planctomycetes	203682|Planctomycetes	KLT	AAA ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,Pkinase
HKD2_k127_6442297_5	269799.Gmet_2155	1.556e-166	545.0	COG2132@1|root,COG2132@2|Bacteria,1MU0J@1224|Proteobacteria,42QGH@68525|delta/epsilon subdivisions,2WKTM@28221|Deltaproteobacteria	28221|Deltaproteobacteria	Q	PFAM multicopper oxidase type 2	-	-	-	-	-	-	-	-	-	-	-	-	Cu-oxidase_2
HKD2_k127_6442297_7	378806.STAUR_1890	4.659e-132	426.0	COG1274@1|root,COG1274@2|Bacteria,1MX3C@1224|Proteobacteria,42PRT@68525|delta/epsilon subdivisions,2WIWH@28221|Deltaproteobacteria,2YU1K@29|Myxococcales	28221|Deltaproteobacteria	H	Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle	pckG	-	4.1.1.32	ko:K01596	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko03320,ko04068,ko04151,ko04152,ko04910,ko04920,ko04922,ko04931,ko04964,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map03320,map04068,map04151,map04152,map04910,map04920,map04922,map04931,map04964	M00003	R00431,R00726	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2638	PEPCK_C,PEPCK_N
HKD2_k127_6442643_2	1382356.JQMP01000004_gene663	9.468e-11	68.0	COG5002@1|root,COG5002@2|Bacteria,2G67W@200795|Chloroflexi,27XFQ@189775|Thermomicrobia	189775|Thermomicrobia	T	His Kinase A (phosphoacceptor) domain	-	-	2.7.13.3	ko:K07636	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS
HKD2_k127_6442643_0	452863.Achl_2080	1.136e-254	818.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,2GMN4@201174|Actinobacteria,1W8KE@1268|Micrococcaceae	201174|Actinobacteria	G	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate	ppsA	-	2.7.9.2	ko:K01007,ko:K21787	ko00333,ko00620,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00333,map00620,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00374,M00837,M00838	R00199,R11662,R11673	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
HKD2_k127_6442643_1	85643.Tmz1t_1412	1.931e-64	233.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2VJ5E@28216|Betaproteobacteria,2KVS8@206389|Rhodocyclales	206389|Rhodocyclales	I	AMP-binding enzyme C-terminal domain	-	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
HKD2_k127_6443214_1	479434.Sthe_3164	5.722e-33	132.0	COG1595@1|root,COG3631@1|root,COG1595@2|Bacteria,COG3631@2|Bacteria,2G7NX@200795|Chloroflexi	200795|Chloroflexi	K	COGs COG1595 DNA-directed RNA polymerase specialized sigma subunit sigma24 homolog	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD2_k127_6443214_0	861299.J421_6353	1.513e-82	278.0	COG3170@1|root,COG3170@2|Bacteria,1ZTDF@142182|Gemmatimonadetes	2|Bacteria	NU	Protein of unknown function (DUF3108)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3108
HKD2_k127_64468_1	1254432.SCE1572_40860	9.949e-143	456.0	COG2766@1|root,COG2766@2|Bacteria,1MVW7@1224|Proteobacteria,42NBQ@68525|delta/epsilon subdivisions,2WKR5@28221|Deltaproteobacteria,2YUIB@29|Myxococcales	28221|Deltaproteobacteria	T	PrkA AAA domain	prkA	-	-	ko:K07180	-	-	-	-	ko00000	-	-	-	AAA_PrkA,PrkA
HKD2_k127_64468_4	1192034.CAP_6237	1.545e-51	199.0	COG5164@1|root,COG5164@2|Bacteria,1R0C5@1224|Proteobacteria,43CUH@68525|delta/epsilon subdivisions,2X826@28221|Deltaproteobacteria,2Z24H@29|Myxococcales	28221|Deltaproteobacteria	K	regulation of DNA-templated transcription, elongation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_64468_5	1192034.CAP_2000	1.04e-37	148.0	COG0801@1|root,COG0801@2|Bacteria,1MZH8@1224|Proteobacteria,42TJ2@68525|delta/epsilon subdivisions,2WQ4P@28221|Deltaproteobacteria,2YVPS@29|Myxococcales	28221|Deltaproteobacteria	H	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK)	folK	-	2.7.6.3	ko:K00950	ko00790,ko01100,map00790,map01100	M00126,M00841	R03503	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	HPPK
HKD2_k127_64468_0	1254432.SCE1572_04480	3.03e-274	856.0	COG1716@1|root,COG2203@1|root,COG3829@1|root,COG1716@2|Bacteria,COG2203@2|Bacteria,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,43BKG@68525|delta/epsilon subdivisions,2X6YI@28221|Deltaproteobacteria,2YZGR@29|Myxococcales	28221|Deltaproteobacteria	KT	Sigma-54 interaction domain	-	-	-	ko:K02584	ko02020,map02020	-	-	-	ko00000,ko00001,ko03000	-	-	-	FHA,GAF,GAF_2,HTH_8,Sigma54_activat,Yop-YscD_cpl
HKD2_k127_64468_3	1254432.SCE1572_04485	1.705e-65	245.0	COG1413@1|root,COG1413@2|Bacteria	2|Bacteria	C	deoxyhypusine monooxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554,DUF4145,Pentapeptide,RDD
HKD2_k127_64468_2	35754.JNYJ01000006_gene5174	4.21e-84	292.0	COG3831@1|root,COG3831@2|Bacteria,2HIEQ@201174|Actinobacteria,4D9WJ@85008|Micromonosporales	201174|Actinobacteria	S	Domain of unknown function (DUF4132)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4132
HKD2_k127_6450594_1	1192034.CAP_0266	2.302e-92	331.0	COG1752@1|root,COG1752@2|Bacteria,1PEH4@1224|Proteobacteria,42XKH@68525|delta/epsilon subdivisions,2WTA6@28221|Deltaproteobacteria,2YWD2@29|Myxococcales	28221|Deltaproteobacteria	S	Patatin-like phospholipase	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
HKD2_k127_6450594_0	448385.sce2753	4.359e-266	844.0	COG0515@1|root,COG3899@1|root,COG0515@2|Bacteria,COG3899@2|Bacteria,1MWVZ@1224|Proteobacteria,438G1@68525|delta/epsilon subdivisions,2X3QZ@28221|Deltaproteobacteria,2YWVV@29|Myxococcales	28221|Deltaproteobacteria	KLT	Serine Threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	AAA_16,PEGA,Pkinase,TPR_12
HKD2_k127_6457709_3	1278073.MYSTI_07391	7.349e-26	109.0	COG2171@1|root,COG2171@2|Bacteria,1MU0Y@1224|Proteobacteria,42SPQ@68525|delta/epsilon subdivisions,2WPX1@28221|Deltaproteobacteria,2YWQX@29|Myxococcales	28221|Deltaproteobacteria	E	Belongs to the transferase hexapeptide repeat family	dapD	-	2.3.1.117	ko:K00674	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R04365	RC00004,RC01136	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,Hexapep_2,THDPS_N_2
HKD2_k127_6457709_2	1254432.SCE1572_17950	2.248e-54	194.0	COG0105@1|root,COG0105@2|Bacteria,1R9ZA@1224|Proteobacteria,42RIR@68525|delta/epsilon subdivisions,2WP3R@28221|Deltaproteobacteria,2YVK9@29|Myxococcales	28221|Deltaproteobacteria	F	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate	ndk	GO:0003674,GO:0003824,GO:0004550,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006165,GO:0006220,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009132,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0019205,GO:0019637,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046483,GO:0046939,GO:0055086,GO:0071704,GO:0072521,GO:0072527,GO:1901360,GO:1901564	2.7.4.6	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	M00049,M00050,M00052,M00053	R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895	RC00002	ko00000,ko00001,ko00002,ko01000,ko04131	-	-	-	NDK
HKD2_k127_6457709_1	765869.BDW_14025	4.577e-122	418.0	COG0074@1|root,COG0074@2|Bacteria,1MUGA@1224|Proteobacteria,42M2W@68525|delta/epsilon subdivisions,2MSQU@213481|Bdellovibrionales,2WJBV@28221|Deltaproteobacteria	213481|Bdellovibrionales	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit	sucD	-	6.2.1.5	ko:K01902	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,CoA_binding,Ligase_CoA
HKD2_k127_6457709_0	1192034.CAP_2395	1.268e-177	564.0	COG0045@1|root,COG0045@2|Bacteria,1MVCE@1224|Proteobacteria,42M5K@68525|delta/epsilon subdivisions,2WJTS@28221|Deltaproteobacteria,2YU09@29|Myxococcales	28221|Deltaproteobacteria	F	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit	sucC	-	6.2.1.5	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2261	ATP-grasp_2,Ligase_CoA
HKD2_k127_646484_1	1192034.CAP_4336	7.356e-150	497.0	COG0457@1|root,COG0457@2|Bacteria,1QX7S@1224|Proteobacteria,43C0S@68525|delta/epsilon subdivisions,2X7BD@28221|Deltaproteobacteria,2YV1Y@29|Myxococcales	28221|Deltaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_646484_3	1192034.CAP_8096	5.74e-25	118.0	COG1994@1|root,COG1994@2|Bacteria,1PC66@1224|Proteobacteria,433UK@68525|delta/epsilon subdivisions,2XA3T@28221|Deltaproteobacteria,2YWAR@29|Myxococcales	28221|Deltaproteobacteria	S	Peptidase family M50	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M50
HKD2_k127_646484_0	1192034.CAP_8538	8.654e-189	611.0	COG0515@1|root,COG1262@1|root,COG0515@2|Bacteria,COG1262@2|Bacteria	2|Bacteria	T	PFAM Formylglycine-generating sulfatase enzyme	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	FGE-sulfatase,Pkinase
HKD2_k127_646484_2	1254432.SCE1572_25750	2.268e-86	303.0	COG0422@1|root,COG0422@2|Bacteria,1MUVV@1224|Proteobacteria,42MMB@68525|delta/epsilon subdivisions,2WJEI@28221|Deltaproteobacteria,2Z2X3@29|Myxococcales	28221|Deltaproteobacteria	H	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction	thiC	-	4.1.99.17	ko:K03147	ko00730,ko01100,map00730,map01100	M00127	R03472	RC03251,RC03252	ko00000,ko00001,ko00002,ko01000	-	-	-	ThiC-associated,ThiC_Rad_SAM
HKD2_k127_6465261_2	448385.sce1598	1.714e-102	339.0	COG1352@1|root,COG1352@2|Bacteria,1MU6W@1224|Proteobacteria,42QPJ@68525|delta/epsilon subdivisions,2WMNM@28221|Deltaproteobacteria,2YUW4@29|Myxococcales	28221|Deltaproteobacteria	H	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP	cheR40H-1	-	2.1.1.80	ko:K00575	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko01000,ko02035	-	-	-	CheR,CheR_N
HKD2_k127_6465261_1	1192034.CAP_0922	1.459e-127	417.0	COG2201@1|root,COG2201@2|Bacteria,1MWCN@1224|Proteobacteria,42M27@68525|delta/epsilon subdivisions,2X5MZ@28221|Deltaproteobacteria,2Z36F@29|Myxococcales	28221|Deltaproteobacteria	J	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR	-	-	3.1.1.61,3.5.1.44	ko:K03412	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest,Response_reg
HKD2_k127_6465261_0	502025.Hoch_3343	1.92e-148	483.0	COG0312@1|root,COG0312@2|Bacteria,1MUVW@1224|Proteobacteria,42RID@68525|delta/epsilon subdivisions,2WN9N@28221|Deltaproteobacteria,2YUME@29|Myxococcales	28221|Deltaproteobacteria	S	Zn-dependent proteases and their inactivated homologs	pmbA	-	-	ko:K03592	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
HKD2_k127_6465261_3	448385.sce2029	3.714e-24	117.0	COG2944@1|root,COG2944@2|Bacteria	2|Bacteria	K	sequence-specific DNA binding	-	-	-	ko:K07726	-	-	-	-	ko00000,ko03000	-	-	-	HTH_3,HTH_31
HKD2_k127_6469883_3	502025.Hoch_2129	2.716e-63	227.0	COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,42MKR@68525|delta/epsilon subdivisions,2X1W0@28221|Deltaproteobacteria,2YUZR@29|Myxococcales	28221|Deltaproteobacteria	E	Aminotransferase class I and II	-	-	2.6.1.17	ko:K14267	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R04475	RC00006	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
HKD2_k127_6469883_0	448385.sce4291	7.678e-123	421.0	COG1228@1|root,COG1228@2|Bacteria,1MUYR@1224|Proteobacteria,42NVH@68525|delta/epsilon subdivisions,2WJN9@28221|Deltaproteobacteria,2YU67@29|Myxococcales	28221|Deltaproteobacteria	F	imidazolonepropionase	hutI	-	3.5.2.7	ko:K01468	ko00340,ko01100,map00340,map01100	M00045	R02288	RC00683	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1,Amidohydro_3
HKD2_k127_6469883_1	1192034.CAP_5280	4.003e-96	329.0	COG1472@1|root,COG1472@2|Bacteria,1MVAJ@1224|Proteobacteria,42N8K@68525|delta/epsilon subdivisions,2WN0Z@28221|Deltaproteobacteria,2YUJN@29|Myxococcales	28221|Deltaproteobacteria	G	Glycosyl hydrolase family 3 N terminal domain	nagZ	-	3.2.1.52	ko:K01207	ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501	M00628	R00022,R05963,R07809,R07810,R10831	RC00049	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyco_hydro_3
HKD2_k127_6469883_2	1254432.SCE1572_25970	2.91e-74	265.0	COG2340@1|root,COG2340@2|Bacteria	2|Bacteria	S	peptidase inhibitor activity	-	-	-	-	-	-	-	-	-	-	-	-	CAP,CarboxypepD_reg,HemolysinCabind
HKD2_k127_6469883_4	1192034.CAP_5298	1.684e-48	191.0	COG0457@1|root,COG0457@2|Bacteria,1NMQD@1224|Proteobacteria,42XCX@68525|delta/epsilon subdivisions,2WSK3@28221|Deltaproteobacteria,2Z31X@29|Myxococcales	28221|Deltaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6469883_6	448385.sce4276	3.348e-35	141.0	COG4969@1|root,COG4969@2|Bacteria,1QWD5@1224|Proteobacteria	1224|Proteobacteria	NU	Belongs to the N-Me-Phe pilin family	-	-	-	ko:K02650	ko02020,map02020	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.15.2	-	-	N_methyl,Pilin
HKD2_k127_6469883_8	1192034.CAP_5301	5.112e-12	74.0	COG4969@1|root,COG4969@2|Bacteria,1R0CQ@1224|Proteobacteria,43CV8@68525|delta/epsilon subdivisions,2X835@28221|Deltaproteobacteria,2Z3JW@29|Myxococcales	28221|Deltaproteobacteria	NU	Prokaryotic N-terminal methylation motif	-	-	-	ko:K02650	ko02020,map02020	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.15.2	-	-	N_methyl
HKD2_k127_6469883_9	118168.MC7420_1471	6.541e-06	59.0	COG0457@1|root,COG0457@2|Bacteria,1G25M@1117|Cyanobacteria,1H9FA@1150|Oscillatoriales	1117|Cyanobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_16,TPR_2,TPR_8
HKD2_k127_6469883_7	69319.XP_008545576.1	1.502e-12	81.0	COG0457@1|root,KOG1124@2759|Eukaryota,38CY4@33154|Opisthokonta,3BDZ9@33208|Metazoa,3CW1H@33213|Bilateria,41VA9@6656|Arthropoda,3SKNK@50557|Insecta,46GGS@7399|Hymenoptera	33208|Metazoa	S	Transmembrane and TPR repeat-containing protein	TMTC2	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005789,GO:0008150,GO:0012505,GO:0016020,GO:0031984,GO:0042175,GO:0042592,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044425,GO:0044432,GO:0044444,GO:0044446,GO:0044464,GO:0048878,GO:0050801,GO:0055065,GO:0055074,GO:0055080,GO:0065007,GO:0065008,GO:0072507,GO:0098771,GO:0098827	-	-	-	-	-	-	-	-	-	-	DUF1736,TPR_1,TPR_16,TPR_2,TPR_8
HKD2_k127_6474804_0	1242864.D187_009677	6.131e-165	529.0	COG0205@1|root,COG0205@2|Bacteria,1R560@1224|Proteobacteria,42P6N@68525|delta/epsilon subdivisions,2WINA@28221|Deltaproteobacteria,2YVFG@29|Myxococcales	28221|Deltaproteobacteria	H	Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions	pfp	-	2.7.1.11,2.7.1.90	ko:K00895,ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
HKD2_k127_6474804_5	1211035.CD30_16535	1.134e-15	89.0	COG0628@1|root,COG0628@2|Bacteria,1TSBK@1239|Firmicutes,4HBYJ@91061|Bacilli,3IWE1@400634|Lysinibacillus	91061|Bacilli	S	AI-2E family transporter	ydbI	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
HKD2_k127_6474804_2	1254432.SCE1572_06315	1.412e-53	202.0	COG2220@1|root,COG2220@2|Bacteria,1R749@1224|Proteobacteria	1224|Proteobacteria	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_3
HKD2_k127_6474804_3	448385.sce7970	6.233e-53	198.0	COG3215@1|root,COG3215@2|Bacteria,1Q3B9@1224|Proteobacteria,4392F@68525|delta/epsilon subdivisions,2X485@28221|Deltaproteobacteria,2YYGF@29|Myxococcales	28221|Deltaproteobacteria	MNU	PilZ domain	-	-	-	-	-	-	-	-	-	-	-	-	PilZ
HKD2_k127_6474804_1	448385.sce7971	1.153e-83	286.0	COG0223@1|root,COG0223@2|Bacteria	2|Bacteria	J	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus	MA20_41110	-	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	-	ACT_6,Formyl_trans_C,Formyl_trans_N
HKD2_k127_6474804_4	272134.KB731324_gene2066	9.566e-21	95.0	COG0618@1|root,COG0618@2|Bacteria,1G12Y@1117|Cyanobacteria,1H759@1150|Oscillatoriales	1117|Cyanobacteria	S	PFAM DHH family	-	-	-	-	-	-	-	-	-	-	-	-	DHH
HKD2_k127_6491608_2	1192034.CAP_6256	3.896e-42	158.0	COG2050@1|root,COG2050@2|Bacteria,1RHK6@1224|Proteobacteria,437UE@68525|delta/epsilon subdivisions,2WYP3@28221|Deltaproteobacteria,2YW4I@29|Myxococcales	28221|Deltaproteobacteria	Q	Thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
HKD2_k127_6491608_0	483219.LILAB_32555	1.187e-71	258.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,1MVEU@1224|Proteobacteria,43AGY@68525|delta/epsilon subdivisions,2X5WX@28221|Deltaproteobacteria,2YWWR@29|Myxococcales	28221|Deltaproteobacteria	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_12,zf-HC2
HKD2_k127_6491608_3	502025.Hoch_5471	3.57e-27	121.0	COG1595@1|root,COG1595@2|Bacteria,1Q2GH@1224|Proteobacteria,43830@68525|delta/epsilon subdivisions,2X0DG@28221|Deltaproteobacteria,2YVH2@29|Myxococcales	28221|Deltaproteobacteria	K	DNA-binding regulatory protein	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r4_2
HKD2_k127_6491608_1	1192034.CAP_6766	1.12e-48	177.0	COG0031@1|root,COG3620@1|root,COG0031@2|Bacteria,COG3620@2|Bacteria,1MUBE@1224|Proteobacteria,42N1R@68525|delta/epsilon subdivisions,2WJ7R@28221|Deltaproteobacteria,2YTZR@29|Myxococcales	28221|Deltaproteobacteria	EK	Pyridoxal-phosphate dependent enzyme	-	-	4.2.1.22	ko:K01697	ko00260,ko00270,ko01100,ko01130,ko01230,map00260,map00270,map01100,map01130,map01230	M00035,M00338	R00891,R01290,R04942	RC00056,RC00069,RC00256,RC00489,RC01246	ko00000,ko00001,ko00002,ko01000	-	-	-	CBS,PALP
HKD2_k127_6509800_0	1254432.SCE1572_02910	3.94e-143	469.0	COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,42MZW@68525|delta/epsilon subdivisions,2WIV1@28221|Deltaproteobacteria,2YUVS@29|Myxococcales	28221|Deltaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PocR
HKD2_k127_6509800_1	1254432.SCE1572_02905	1.187e-67	258.0	COG0611@1|root,COG0611@2|Bacteria,1MU9X@1224|Proteobacteria,42MYJ@68525|delta/epsilon subdivisions,2WNGE@28221|Deltaproteobacteria,2YVMB@29|Myxococcales	28221|Deltaproteobacteria	H	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1	thiL	-	2.7.4.16	ko:K00946	ko00730,ko01100,map00730,map01100	M00127	R00617	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
HKD2_k127_6509800_2	1192034.CAP_8395	3.449e-20	90.0	COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,42N8M@68525|delta/epsilon subdivisions,2WJRT@28221|Deltaproteobacteria,2YUBZ@29|Myxococcales	28221|Deltaproteobacteria	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	nrdA1	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_2_N,Ribonuc_red_lgC
HKD2_k127_6511096_3	448385.sce8438	1.18e-27	130.0	COG0484@1|root,COG0484@2|Bacteria	2|Bacteria	O	heat shock protein binding	dnaJ	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
HKD2_k127_6511096_5	267608.RSc3402	0.0003724	53.0	COG1266@1|root,COG1266@2|Bacteria,1RCJ4@1224|Proteobacteria,2VQUP@28216|Betaproteobacteria,1K6XK@119060|Burkholderiaceae	28216|Betaproteobacteria	S	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
HKD2_k127_6511096_0	1123508.JH636442_gene4099	3.761e-211	680.0	COG0855@1|root,COG0855@2|Bacteria,2IWVK@203682|Planctomycetes	203682|Planctomycetes	H	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)	ppk	-	2.7.4.1	ko:K00937	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PP_kinase,PP_kinase_C,PP_kinase_N
HKD2_k127_6511096_4	252305.OB2597_05515	1.091e-13	85.0	COG1807@1|root,COG1807@2|Bacteria,1Q255@1224|Proteobacteria,2V9M6@28211|Alphaproteobacteria,2PF7E@252301|Oceanicola	28211|Alphaproteobacteria	M	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6511096_2	1173024.KI912149_gene5478	1.388e-57	216.0	COG0618@1|root,COG0618@2|Bacteria,1G12Y@1117|Cyanobacteria,1JI21@1189|Stigonemataceae	1117|Cyanobacteria	S	DHH family	-	-	-	-	-	-	-	-	-	-	-	-	DHH
HKD2_k127_6511096_1	448385.sce7971	1.238e-63	223.0	COG0223@1|root,COG0223@2|Bacteria	2|Bacteria	J	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus	MA20_41110	-	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	-	ACT_6,Formyl_trans_C,Formyl_trans_N
HKD2_k127_6513554_2	1122212.AULO01000014_gene1157	4.066e-43	169.0	COG1716@1|root,COG2114@1|root,COG1716@2|Bacteria,COG2114@2|Bacteria,1NAJG@1224|Proteobacteria,1RYIU@1236|Gammaproteobacteria,1XKCX@135619|Oceanospirillales	135619|Oceanospirillales	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	FHA,Guanylate_cyc
HKD2_k127_6513554_1	234267.Acid_4171	3.008e-61	223.0	COG0491@1|root,COG0491@2|Bacteria,3Y54H@57723|Acidobacteria	57723|Acidobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HKD2_k127_6513554_0	187272.Mlg_0941	1.151e-109	358.0	COG1217@1|root,COG1217@2|Bacteria,1MV5Q@1224|Proteobacteria,1RMJB@1236|Gammaproteobacteria,1WW7K@135613|Chromatiales	135613|Chromatiales	T	GTP-binding protein TypA	-	-	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2
HKD2_k127_6521940_3	1192034.CAP_0902	5.865e-29	126.0	COG0026@1|root,COG0026@2|Bacteria,1MU70@1224|Proteobacteria,42PQI@68525|delta/epsilon subdivisions,2WKZR@28221|Deltaproteobacteria,2YUAG@29|Myxococcales	28221|Deltaproteobacteria	F	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)	purK	-	6.3.4.18	ko:K01589	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07404	RC01927	ko00000,ko00001,ko00002,ko01000	-	-	-	2-Hacid_dh_C,ATP-grasp
HKD2_k127_6521940_2	240015.ACP_2356	5.723e-61	214.0	COG0041@1|root,COG0041@2|Bacteria,3Y4MB@57723|Acidobacteria,2JJ9S@204432|Acidobacteriia	204432|Acidobacteriia	F	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)	purE	-	5.4.99.18	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07405	RC01947	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRC
HKD2_k127_6521940_1	1298867.AUES01000003_gene1014	1.027e-61	215.0	COG0229@1|root,COG0229@2|Bacteria,1RGWC@1224|Proteobacteria,2U70T@28211|Alphaproteobacteria,3JY1U@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	O	Belongs to the MsrB Met sulfoxide reductase family	msrB	-	1.8.4.12	ko:K07305	-	-	-	-	ko00000,ko01000	-	-	-	SelR
HKD2_k127_6521940_0	1254432.SCE1572_00405	1.182e-81	280.0	COG1281@1|root,COG1281@2|Bacteria,1MUMU@1224|Proteobacteria,42Q9R@68525|delta/epsilon subdivisions,2WK2C@28221|Deltaproteobacteria,2YVZD@29|Myxococcales	28221|Deltaproteobacteria	O	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress	hslO	-	-	ko:K04083	-	-	-	-	ko00000,ko03110	-	-	-	HSP33
HKD2_k127_6528672_4	439235.Dalk_2235	1.222e-13	72.0	COG0863@1|root,COG0863@2|Bacteria	2|Bacteria	L	N-4 methylation of cytosine	-	-	-	-	-	-	-	-	-	-	-	-	N6_N4_Mtase
HKD2_k127_6528672_3	575589.HMPREF0018_01592	5.476e-19	98.0	COG3652@1|root,COG3652@2|Bacteria,1RGSQ@1224|Proteobacteria,1SH1C@1236|Gammaproteobacteria,3NNPI@468|Moraxellaceae	1236|Gammaproteobacteria	S	Domain of unknown function (DUF4142)	-	-	-	ko:K08995	-	-	-	-	ko00000	-	-	-	DUF4142
HKD2_k127_6528672_1	509635.N824_20700	1.623e-39	153.0	COG2259@1|root,COG2259@2|Bacteria,4NYPC@976|Bacteroidetes,1IZT9@117747|Sphingobacteriia	976|Bacteroidetes	S	SURF4 family	-	-	-	ko:K15977	-	-	-	-	ko00000	-	-	-	DoxX,SURF4
HKD2_k127_6528672_0	502025.Hoch_4952	8.544e-41	161.0	COG0745@1|root,COG0745@2|Bacteria,1QVDV@1224|Proteobacteria,43APF@68525|delta/epsilon subdivisions,2X631@28221|Deltaproteobacteria,2Z38J@29|Myxococcales	28221|Deltaproteobacteria	T	Domain of unknown function (DUF4388)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4388,Response_reg
HKD2_k127_6528672_2	278957.ABEA03000050_gene149	4.524e-34	132.0	COG0046@1|root,COG0047@1|root,COG0046@2|Bacteria,COG0047@2|Bacteria,46U8Q@74201|Verrucomicrobia,3K77Q@414999|Opitutae	414999|Opitutae	F	Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS_C,GATase_5
HKD2_k127_6530785_5	1144343.PMI41_04062	1.734e-05	49.0	COG2900@1|root,COG2900@2|Bacteria,1NE5S@1224|Proteobacteria,2UHUR@28211|Alphaproteobacteria,43M22@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Belongs to the SlyX family	slyX	-	-	ko:K03745	-	-	-	-	ko00000	-	-	-	SlyX
HKD2_k127_6530785_2	290397.Adeh_0078	9.977e-47	184.0	2A9VF@1|root,30Z3B@2|Bacteria,1PKZS@1224|Proteobacteria,435JG@68525|delta/epsilon subdivisions,2WZXJ@28221|Deltaproteobacteria,2Z0YG@29|Myxococcales	290397.Adeh_0078|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6530785_0	1192034.CAP_0602	5.203e-95	317.0	COG0377@1|root,COG0377@2|Bacteria,1MUI2@1224|Proteobacteria,42MDJ@68525|delta/epsilon subdivisions,2WN9U@28221|Deltaproteobacteria,2YUX6@29|Myxococcales	28221|Deltaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoB	GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564	1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	iAF987.Gmet_3354	Oxidored_q6
HKD2_k127_6530785_1	1192034.CAP_0603	1.985e-67	238.0	COG0852@1|root,COG0852@2|Bacteria,1MX4B@1224|Proteobacteria,42NAR@68525|delta/epsilon subdivisions,2WQB1@28221|Deltaproteobacteria,2YVJM@29|Myxococcales	28221|Deltaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoC	GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564	1.6.5.3	ko:K00332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	iAF987.Gmet_3353	Complex1_30kDa
HKD2_k127_6530785_4	1192034.CAP_0604	8.085e-10	64.0	COG0649@1|root,COG0649@2|Bacteria,1MVIN@1224|Proteobacteria,42M9G@68525|delta/epsilon subdivisions,2WIS7@28221|Deltaproteobacteria,2YU4Q@29|Myxococcales	28221|Deltaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0016020,GO:0044424,GO:0044464,GO:0071944	1.6.5.3	ko:K00333,ko:K13378	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa,Complex1_49kDa
HKD2_k127_6533104_1	4536.ONIVA03G30910.1	2.753e-09	65.0	COG0457@1|root,COG0666@1|root,KOG0504@2759|Eukaryota,KOG0548@2759|Eukaryota,37HF2@33090|Viridiplantae,3G8J9@35493|Streptophyta,3M296@4447|Liliopsida,3IDRJ@38820|Poales	35493|Streptophyta	O	Ankyrin repeats (3 copies)	-	-	-	-	-	-	-	-	-	-	-	-	Ank_2,Ank_3,TPR_2,TPR_8
HKD2_k127_6533104_0	755731.Clo1100_3321	5.069e-13	81.0	COG0641@1|root,COG0641@2|Bacteria,1TQPS@1239|Firmicutes,247Z9@186801|Clostridia,36E92@31979|Clostridiaceae	186801|Clostridia	C	anaerobic sulfatase-maturating enzyme	-	-	-	ko:K06871	-	-	-	-	ko00000	-	-	-	Fer4_12,Fer4_14,Radical_SAM,SPASM
HKD2_k127_6534992_0	1254432.SCE1572_51340	1.217e-221	699.0	COG2203@1|root,COG2204@1|root,COG2203@2|Bacteria,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2X70S@28221|Deltaproteobacteria,2Z3KV@29|Myxococcales	28221|Deltaproteobacteria	T	GAF domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HTH_8,Sigma54_activat
HKD2_k127_6534992_2	448385.sce9034	1.793e-120	400.0	COG1235@1|root,COG1235@2|Bacteria,1NW4Z@1224|Proteobacteria,42S6D@68525|delta/epsilon subdivisions,2WNEA@28221|Deltaproteobacteria,2Z344@29|Myxococcales	28221|Deltaproteobacteria	S	beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
HKD2_k127_6534992_6	483219.LILAB_33705	3.599e-06	53.0	COG0643@1|root,COG0784@1|root,COG0643@2|Bacteria,COG0784@2|Bacteria,1MUAG@1224|Proteobacteria,439YY@68525|delta/epsilon subdivisions,2X1I2@28221|Deltaproteobacteria,2YW92@29|Myxococcales	28221|Deltaproteobacteria	T	Histidine kinase	cheA3	-	2.7.13.3	ko:K03407,ko:K13490	ko02020,ko02025,ko02030,map02020,map02025,map02030	M00506,M00509	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	CheW,HATPase_c,Hpt,Response_reg
HKD2_k127_6534992_4	1117315.AHCA01000006_gene2931	1.746e-46	186.0	COG0584@1|root,COG0737@1|root,COG0584@2|Bacteria,COG0737@2|Bacteria,1NTU5@1224|Proteobacteria,1RR0F@1236|Gammaproteobacteria,2Q04P@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	CF	Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
HKD2_k127_6534992_5	1206744.BAGL01000028_gene7563	1.695e-06	59.0	2DHBJ@1|root,32Y5U@2|Bacteria,2I85X@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6534992_1	1192034.CAP_5323	3.759e-139	450.0	COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,42M7F@68525|delta/epsilon subdivisions,2WJ4Z@28221|Deltaproteobacteria,2YXJE@29|Myxococcales	28221|Deltaproteobacteria	NU	twitching motility protein	pilT1	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
HKD2_k127_6534992_3	448385.sce4250	8.786e-74	250.0	COG0422@1|root,COG0422@2|Bacteria,1MUVV@1224|Proteobacteria,42MMB@68525|delta/epsilon subdivisions,2WJEI@28221|Deltaproteobacteria,2Z2X3@29|Myxococcales	28221|Deltaproteobacteria	H	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction	thiC	-	4.1.99.17	ko:K03147	ko00730,ko01100,map00730,map01100	M00127	R03472	RC03251,RC03252	ko00000,ko00001,ko00002,ko01000	-	-	-	ThiC-associated,ThiC_Rad_SAM
HKD2_k127_6539891_0	215803.DB30_5584	5.262e-167	535.0	COG0076@1|root,COG0076@2|Bacteria,1MX25@1224|Proteobacteria,42NCK@68525|delta/epsilon subdivisions,2WMCF@28221|Deltaproteobacteria,2YTU4@29|Myxococcales	28221|Deltaproteobacteria	E	Pyridoxal-dependent decarboxylase conserved domain	-	-	4.1.2.27	ko:K01634	ko00600,ko01100,ko04071,map00600,map01100,map04071	M00100	R02464,R06516	RC00264,RC00721,RC01266	ko00000,ko00001,ko00002,ko01000	-	-	-	Pyridoxal_deC
HKD2_k127_6539891_2	448385.sce3607	6.405e-98	354.0	COG1376@1|root,COG1376@2|Bacteria,1NKBB@1224|Proteobacteria,432T9@68525|delta/epsilon subdivisions,2X2MM@28221|Deltaproteobacteria,2Z0G3@29|Myxococcales	28221|Deltaproteobacteria	S	L,D-transpeptidase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	YkuD
HKD2_k127_6539891_7	448385.sce1849	9.228e-09	66.0	2AH4J@1|root,317E7@2|Bacteria,1PYQD@1224|Proteobacteria,435HH@68525|delta/epsilon subdivisions,2WZV3@28221|Deltaproteobacteria,2Z2TC@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6539891_3	1254432.SCE1572_32345	6.735e-78	280.0	COG2720@1|root,COG2720@2|Bacteria,1NG7U@1224|Proteobacteria,4319R@68525|delta/epsilon subdivisions,2WW7C@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	PFAM VanW family protein	-	-	-	ko:K18346	ko01502,ko02020,map01502,map02020	M00651	-	-	ko00000,ko00001,ko00002,ko01504	-	-	-	PG_binding_4,VanW
HKD2_k127_6539891_5	215803.DB30_4101	4.633e-38	151.0	COG2197@1|root,COG2197@2|Bacteria,1NCBR@1224|Proteobacteria,433WZ@68525|delta/epsilon subdivisions,2X3XU@28221|Deltaproteobacteria,2YXHT@29|Myxococcales	28221|Deltaproteobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE
HKD2_k127_6539891_4	1278073.MYSTI_00292	3.092e-61	227.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,42NB6@68525|delta/epsilon subdivisions,2WIWE@28221|Deltaproteobacteria,2YWNQ@29|Myxococcales	28221|Deltaproteobacteria	O	Domain present in PSD-95, Dlg, and ZO-1/2.	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
HKD2_k127_6539891_1	448385.sce4534	4.398e-147	491.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,42MVV@68525|delta/epsilon subdivisions	1224|Proteobacteria	KLT	Family membership	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PP2C_2,Pkinase
HKD2_k127_6539891_6	1254432.SCE1572_37735	1.309e-29	124.0	COG2010@1|root,COG2010@2|Bacteria,1QX4J@1224|Proteobacteria,43CNY@68525|delta/epsilon subdivisions,2X7W8@28221|Deltaproteobacteria,2YX21@29|Myxococcales	28221|Deltaproteobacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cu2_monoox_C,Cu2_monooxygen
HKD2_k127_6547825_2	1121015.N789_06805	3.15e-16	88.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1XDCB@135614|Xanthomonadales	135614|Xanthomonadales	T	Putative diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS_3
HKD2_k127_6547825_1	1198114.AciX9_2599	2.426e-35	155.0	COG2930@1|root,COG2930@2|Bacteria,3Y2F0@57723|Acidobacteria,2JIT6@204432|Acidobacteriia	204432|Acidobacteriia	S	Las17-binding protein actin regulator	-	-	-	-	-	-	-	-	-	-	-	-	Ysc84
HKD2_k127_6548448_1	1192034.CAP_4387	3.845e-149	481.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,42MK5@68525|delta/epsilon subdivisions,2WJ3Z@28221|Deltaproteobacteria,2YU5D@29|Myxococcales	28221|Deltaproteobacteria	C	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HKD2_k127_6548448_2	1464048.JNZS01000007_gene4318	1.873e-09	65.0	COG1846@1|root,COG1846@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	-	-	-	-	-	-	-	-	-	-	-	-	MarR_2
HKD2_k127_6548448_0	1267535.KB906767_gene823	2.194e-156	519.0	COG1198@1|root,COG1198@2|Bacteria,3Y2NY@57723|Acidobacteria,2JI1K@204432|Acidobacteriia	204432|Acidobacteriia	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	-	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,ResIII
HKD2_k127_6553945_0	269799.Gmet_1210	5.351e-124	409.0	COG1858@1|root,COG1858@2|Bacteria,1MV70@1224|Proteobacteria,42N38@68525|delta/epsilon subdivisions,2WK56@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	cytochrome c peroxidase	-	-	-	-	-	-	-	-	-	-	-	-	CCP_MauG,Cytochrom_C
HKD2_k127_6553945_1	378806.STAUR_2407	3.436e-31	138.0	COG3826@1|root,COG3826@2|Bacteria,1QYZS@1224|Proteobacteria	1224|Proteobacteria	S	Oxygenase, catalysing oxidative methylation of damaged DNA	-	-	-	-	-	-	-	-	-	-	-	-	2OG-FeII_Oxy_3
HKD2_k127_6553945_5	1206743.BAGM01000117_gene1572	9.512e-06	55.0	2C28Q@1|root,32RA0@2|Bacteria,2IJRV@201174|Actinobacteria,4FWWR@85025|Nocardiaceae	201174|Actinobacteria	-	-	-	-	-	ko:K14627	ko01057,ko01130,map01057,map01130	M00779	R09308	RC02485	ko00000,ko00001,ko00002,ko01000,ko01008	-	-	-	-
HKD2_k127_6553945_4	1286631.X805_09550	2.102e-07	63.0	COG5653@1|root,COG5653@2|Bacteria,1Q8ZK@1224|Proteobacteria,2VVZ2@28216|Betaproteobacteria,1KNKF@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_6
HKD2_k127_6553945_2	338963.Pcar_1532	5.693e-25	114.0	2ART5@1|root,336GI@2|Bacteria,1R39N@1224|Proteobacteria,4322V@68525|delta/epsilon subdivisions,2WWQQ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6553945_3	1121272.KB903272_gene121	5.362e-12	75.0	2ART5@1|root,31H4G@2|Bacteria,2I83W@201174|Actinobacteria,4DIX7@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6556544_7	1123508.JH636440_gene2646	2.29e-08	60.0	COG4191@1|root,COG4191@2|Bacteria,2IWUM@203682|Planctomycetes	203682|Planctomycetes	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
HKD2_k127_6556544_6	1227488.C477_07383	5.474e-09	69.0	COG0726@1|root,arCOG02878@2157|Archaea,2XT6D@28890|Euryarchaeota,23TT6@183963|Halobacteria	183963|Halobacteria	G	deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
HKD2_k127_6556544_1	1444711.CCJF01000004_gene2392	2.323e-24	119.0	COG1216@1|root,COG1216@2|Bacteria	2|Bacteria	V	Glycosyl transferase, family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_7C,Glycos_transf_2
HKD2_k127_6556544_8	103733.JNYO01000003_gene8290	1.285e-05	58.0	COG0535@1|root,COG0535@2|Bacteria,2GNSY@201174|Actinobacteria,4E6Q9@85010|Pseudonocardiales	201174|Actinobacteria	C	4Fe-4S single cluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM,SPASM
HKD2_k127_6556544_0	749927.AMED_5540	1.905e-35	147.0	COG1216@1|root,COG1216@2|Bacteria,2GP1N@201174|Actinobacteria,4E7D7@85010|Pseudonocardiales	201174|Actinobacteria	S	N-terminal domain of galactosyltransferase	-	-	2.4.1.338	ko:K20438	ko00525,ko01130,map00525,map01130	M00815	R11241	RC00049	ko00000,ko00001,ko00002,ko01000	-	GT2	-	Glyco_transf_7C,Glycos_transf_2
HKD2_k127_6556544_4	502025.Hoch_6508	3.587e-19	102.0	COG0535@1|root,COG0535@2|Bacteria,1MUQP@1224|Proteobacteria,42M55@68525|delta/epsilon subdivisions,2WIKM@28221|Deltaproteobacteria,2Z1QF@29|Myxococcales	28221|Deltaproteobacteria	C	Iron-sulfur cluster-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM,SPASM
HKD2_k127_6556544_5	287.DR97_3479	1.21e-16	93.0	COG0535@1|root,COG0535@2|Bacteria,1MUQP@1224|Proteobacteria,1RSKA@1236|Gammaproteobacteria,1YJD8@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	C	4Fe-4S single cluster domain	nirJ	-	-	ko:K06139	-	-	-	-	ko00000	-	-	-	Fer4_12,Radical_SAM,SPASM
HKD2_k127_6556544_3	661478.OP10G_0122	6.222e-22	107.0	COG3934@1|root,COG4124@1|root,COG3934@2|Bacteria,COG4124@2|Bacteria	2|Bacteria	G	Belongs to the glycosyl hydrolase 26 family	-	-	3.1.1.53,3.2.1.78,3.2.1.81	ko:K01218,ko:K01219,ko:K05970,ko:K19355	ko00051,ko02024,map00051,map02024	-	R01332	RC00467	ko00000,ko00001,ko01000	-	GH26	-	CBM_35,Cellulase,Dockerin_1,Glyco_hydro_2_C
HKD2_k127_6556544_2	187303.BN69_1302	1.749e-22	113.0	COG4485@1|root,COG4485@2|Bacteria,1NBM0@1224|Proteobacteria,2U1FH@28211|Alphaproteobacteria,36ZEE@31993|Methylocystaceae	28211|Alphaproteobacteria	S	Bacterial membrane protein, YfhO	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6559134_0	1267534.KB906754_gene2901	2.003e-108	359.0	COG3064@1|root,COG3064@2|Bacteria	2|Bacteria	M	translation initiation factor activity	-	-	-	-	-	-	-	-	-	-	-	-	Collagen,DUF3300
HKD2_k127_6559134_5	1144275.COCOR_00962	1.155e-76	264.0	COG2114@1|root,COG2114@2|Bacteria,1ND4Q@1224|Proteobacteria,4393V@68525|delta/epsilon subdivisions,2X49U@28221|Deltaproteobacteria,2YYJZ@29|Myxococcales	28221|Deltaproteobacteria	T	Protein of unknown function (DUF2652)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2652
HKD2_k127_6559134_2	1303518.CCALI_02044	1.317e-96	335.0	2EE91@1|root,3383F@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6559134_6	1144275.COCOR_01778	2.759e-60	213.0	COG3812@1|root,COG3812@2|Bacteria,1RGUV@1224|Proteobacteria,43B1P@68525|delta/epsilon subdivisions,2X6FU@28221|Deltaproteobacteria,2YUYE@29|Myxococcales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF1993)	-	-	-	ko:K09983	-	-	-	-	ko00000	-	-	-	DUF1993
HKD2_k127_6559134_7	1122239.AULS01000001_gene1909	4.952e-43	172.0	COG3384@1|root,COG3384@2|Bacteria,2GKTV@201174|Actinobacteria	201174|Actinobacteria	S	Extradiol ring-cleavage dioxygenase	-	-	-	ko:K15777	ko00965,map00965	-	R08836	RC00387	ko00000,ko00001,ko01000	-	-	-	LigB
HKD2_k127_6559134_3	1192034.CAP_4442	1.092e-95	334.0	COG0515@1|root,COG0515@2|Bacteria	1192034.CAP_4442|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6559134_4	448385.sce5153	1.036e-80	290.0	29X07@1|root,30ING@2|Bacteria,1PDK6@1224|Proteobacteria,43E67@68525|delta/epsilon subdivisions,2WZUQ@28221|Deltaproteobacteria,2Z2SP@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6559134_1	378806.STAUR_5632	4.579e-106	351.0	COG1117@1|root,COG1117@2|Bacteria,1MU16@1224|Proteobacteria,42MWA@68525|delta/epsilon subdivisions,2WJEX@28221|Deltaproteobacteria,2YUBB@29|Myxococcales	28221|Deltaproteobacteria	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	pstB	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
HKD2_k127_6559134_10	1242864.D187_004407	1.187e-06	60.0	COG0226@1|root,COG0226@2|Bacteria,1MVXP@1224|Proteobacteria,42P0G@68525|delta/epsilon subdivisions,2WK7Y@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	TIGRFAM phosphate binding protein	-	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
HKD2_k127_6559276_1	1254432.SCE1572_08670	1.126e-99	340.0	COG4826@1|root,COG4826@2|Bacteria,1REGX@1224|Proteobacteria,42T9N@68525|delta/epsilon subdivisions,2WPDB@28221|Deltaproteobacteria,2YV97@29|Myxococcales	28221|Deltaproteobacteria	O	Belongs to the serpin family	-	-	-	ko:K13963	ko05146,map05146	-	-	-	ko00000,ko00001	-	-	-	Serpin
HKD2_k127_6559276_5	1192034.CAP_7416	1.003e-20	106.0	COG3815@1|root,COG3815@2|Bacteria	2|Bacteria	S	Predicted membrane protein (DUF2085)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2085
HKD2_k127_6559276_0	1254432.SCE1572_44060	3.365e-117	386.0	COG1744@1|root,COG1744@2|Bacteria,1NGHH@1224|Proteobacteria,42RBQ@68525|delta/epsilon subdivisions,2WN1W@28221|Deltaproteobacteria,2YV0U@29|Myxococcales	28221|Deltaproteobacteria	S	ABC transporter substrate-binding protein PnrA-like	-	-	-	ko:K07335	-	-	-	-	ko00000	-	-	-	Bmp
HKD2_k127_6559276_2	1297742.A176_02498	3.44e-70	255.0	COG0515@1|root,COG0515@2|Bacteria	1297742.A176_02498|-	KLT	protein kinase activity	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	-
HKD2_k127_6559276_6	1254432.SCE1572_19725	2.932e-10	73.0	COG0457@1|root,COG4995@1|root,COG0457@2|Bacteria,COG4995@2|Bacteria,1MWRF@1224|Proteobacteria,42P9S@68525|delta/epsilon subdivisions,2WJI7@28221|Deltaproteobacteria,2YTSQ@29|Myxococcales	28221|Deltaproteobacteria	H	CHAT domain	-	-	-	-	-	-	-	-	-	-	-	-	CHAT,TPR_10,TPR_12,TPR_7,TPR_8
HKD2_k127_6559276_3	314278.NB231_00350	5.74e-62	225.0	COG0053@1|root,COG0053@2|Bacteria,1MVH8@1224|Proteobacteria,1RQ3E@1236|Gammaproteobacteria,1WY4U@135613|Chromatiales	135613|Chromatiales	P	PFAM Cation efflux	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,ZT_dimer
HKD2_k127_6559276_4	1254432.SCE1572_13895	3.198e-38	145.0	COG1595@1|root,COG1595@2|Bacteria,1QRUX@1224|Proteobacteria,434VK@68525|delta/epsilon subdivisions,2WZ6Q@28221|Deltaproteobacteria,2Z1FT@29|Myxococcales	28221|Deltaproteobacteria	K	Sigma-70, region 4	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r4_2
HKD2_k127_6560143_1	1254432.SCE1572_25735	1.431e-142	456.0	COG0502@1|root,COG0502@2|Bacteria,1MVFF@1224|Proteobacteria,42PK8@68525|delta/epsilon subdivisions,2X5GR@28221|Deltaproteobacteria,2YV7E@29|Myxococcales	28221|Deltaproteobacteria	H	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism	bioB	-	2.8.1.6	ko:K01012	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R01078	RC00441	ko00000,ko00001,ko00002,ko01000	-	-	-	BATS,Radical_SAM
HKD2_k127_6560143_9	1417296.U879_09980	3.037e-11	77.0	COG1807@1|root,COG1807@2|Bacteria,1P6JE@1224|Proteobacteria,2TV39@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	COG1807 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family	MA20_09520	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HKD2_k127_6560143_5	290397.Adeh_2625	1.187e-51	205.0	COG0763@1|root,COG0763@2|Bacteria,1MVBI@1224|Proteobacteria,42P35@68525|delta/epsilon subdivisions,2WJFA@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxB	GO:0003674,GO:0005488,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008289,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0019637,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	2.4.1.182	ko:K00748	ko00540,ko01100,map00540,map01100	M00060	R04606	RC00005,RC00059	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT19	-	LpxB
HKD2_k127_6560143_3	1254432.SCE1572_25715	4.937e-64	231.0	COG5549@1|root,COG5549@2|Bacteria,1PBXR@1224|Proteobacteria,43864@68525|delta/epsilon subdivisions,2X0VV@28221|Deltaproteobacteria,2YVXH@29|Myxococcales	28221|Deltaproteobacteria	O	Zinc-dependent metalloprotease	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M10
HKD2_k127_6560143_7	1192034.CAP_5328	1.571e-20	99.0	2EHJS@1|root,33BBN@2|Bacteria,1NP80@1224|Proteobacteria,439MQ@68525|delta/epsilon subdivisions,2X4YU@28221|Deltaproteobacteria,2YZV4@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6560143_0	1254432.SCE1572_30720	1.751e-156	500.0	COG0332@1|root,COG0332@2|Bacteria,1MU9N@1224|Proteobacteria,42MU6@68525|delta/epsilon subdivisions,2WIJN@28221|Deltaproteobacteria,2YU4F@29|Myxococcales	28221|Deltaproteobacteria	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	-	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
HKD2_k127_6560143_2	1254432.SCE1572_48320	1.59e-79	275.0	COG0061@1|root,COG0061@2|Bacteria,1QA5I@1224|Proteobacteria,434V4@68525|delta/epsilon subdivisions,2WZ66@28221|Deltaproteobacteria,2Z1EN@29|Myxococcales	28221|Deltaproteobacteria	G	ATP-NAD kinase	-	-	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	NAD_kinase
HKD2_k127_6560143_6	1254432.SCE1572_48315	3.052e-46	176.0	COG0494@1|root,COG0494@2|Bacteria,1Q2GD@1224|Proteobacteria,433T7@68525|delta/epsilon subdivisions,2X3CU@28221|Deltaproteobacteria,2YVG9@29|Myxococcales	28221|Deltaproteobacteria	L	nUDIX hydrolase	-	-	3.6.1.13	ko:K01515	ko00230,map00230	-	R01054	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX
HKD2_k127_6560143_4	1254432.SCE1572_35195	5.177e-58	215.0	COG1196@1|root,COG1196@2|Bacteria,1Q5CV@1224|Proteobacteria,439J1@68525|delta/epsilon subdivisions,2X4VH@28221|Deltaproteobacteria,2Z08N@29|Myxococcales	28221|Deltaproteobacteria	D	nuclear chromosome segregation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6565236_4	1382306.JNIM01000001_gene2538	4.527e-35	141.0	COG0604@1|root,COG0604@2|Bacteria,2G6KH@200795|Chloroflexi	200795|Chloroflexi	C	PFAM Alcohol dehydrogenase zinc-binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
HKD2_k127_6565236_3	1280950.HJO_10219	2.936e-47	176.0	COG0756@1|root,COG0756@2|Bacteria,1RA7P@1224|Proteobacteria,2U7B5@28211|Alphaproteobacteria,43XND@69657|Hyphomonadaceae	28211|Alphaproteobacteria	F	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA	dut	GO:0000287,GO:0003674,GO:0003824,GO:0004170,GO:0005488,GO:0006139,GO:0006220,GO:0006221,GO:0006226,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009141,GO:0009143,GO:0009147,GO:0009149,GO:0009157,GO:0009162,GO:0009165,GO:0009166,GO:0009176,GO:0009177,GO:0009200,GO:0009204,GO:0009211,GO:0009213,GO:0009219,GO:0009221,GO:0009223,GO:0009262,GO:0009263,GO:0009264,GO:0009265,GO:0009394,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046078,GO:0046080,GO:0046081,GO:0046385,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0047429,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0072529,GO:0090407,GO:1901135,GO:1901136,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576	3.6.1.23	ko:K01520	ko00240,ko00983,ko01100,map00240,map00983,map01100	M00053	R02100,R11896	RC00002	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	dUTPase
HKD2_k127_6565236_1	1192034.CAP_4442	8.2e-121	405.0	COG0515@1|root,COG0515@2|Bacteria	1192034.CAP_4442|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6565236_0	1192034.CAP_8105	1.08e-228	719.0	COG0519@1|root,COG0519@2|Bacteria,1MU2A@1224|Proteobacteria,42M0I@68525|delta/epsilon subdivisions,2WJ6D@28221|Deltaproteobacteria,2YTZV@29|Myxococcales	28221|Deltaproteobacteria	F	Catalyzes the synthesis of GMP from XMP	guaA	GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase,GMP_synt_C,NAD_synthase,tRNA_Me_trans
HKD2_k127_6565236_2	1192034.CAP_8681	7.507e-86	304.0	COG1446@1|root,COG1446@2|Bacteria,1MWFC@1224|Proteobacteria,42NRH@68525|delta/epsilon subdivisions,2WNIB@28221|Deltaproteobacteria,2YV7G@29|Myxococcales	28221|Deltaproteobacteria	E	Asparaginase	-	-	3.4.19.5	ko:K13051	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Asparaginase_2
HKD2_k127_6565236_11	1450694.BTS2_3269	8.329e-07	61.0	COG5184@1|root,COG5184@2|Bacteria,1UWIF@1239|Firmicutes,4I683@91061|Bacilli,1ZEHV@1386|Bacillus	91061|Bacilli	DZ	Cadherin-like beta sandwich domain	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin-like
HKD2_k127_6565236_8	595537.Varpa_4552	1.085e-09	70.0	COG4719@1|root,COG4932@1|root,COG4719@2|Bacteria,COG4932@2|Bacteria,1QWYJ@1224|Proteobacteria	1224|Proteobacteria	M	TIGRFAM conserved repeat domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF11
HKD2_k127_6565646_3	1172186.KB911462_gene552	9.584e-47	174.0	COG0604@1|root,COG0604@2|Bacteria,2I9RH@201174|Actinobacteria,234ZE@1762|Mycobacteriaceae	201174|Actinobacteria	C	alcohol dehydrogenase	qor_1	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N,ADH_zinc_N_2
HKD2_k127_6565646_2	485918.Cpin_4256	3.52e-58	208.0	COG4430@1|root,COG4430@2|Bacteria,4NN4Z@976|Bacteroidetes,1IRTA@117747|Sphingobacteriia	976|Bacteroidetes	S	Bacteriocin-protection, YdeI or OmpD-Associated	-	-	-	-	-	-	-	-	-	-	-	-	OmdA
HKD2_k127_6565646_0	1121422.AUMW01000056_gene42	6.705e-159	519.0	COG2132@1|root,COG2132@2|Bacteria,1TQSU@1239|Firmicutes,24CJP@186801|Clostridia,260KE@186807|Peptococcaceae	186801|Clostridia	Q	Multicopper oxidase	-	-	1.16.3.3	ko:K06324	-	-	-	-	ko00000,ko01000	-	-	-	Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3
HKD2_k127_6565646_1	269799.Gmet_0138	8.483e-82	280.0	COG5316@1|root,COG5316@2|Bacteria,1QCVP@1224|Proteobacteria,42QA4@68525|delta/epsilon subdivisions,2WKD1@28221|Deltaproteobacteria,43SDE@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF4139)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4139,DUF4140
HKD2_k127_6567168_0	1192034.CAP_2972	1.777e-286	897.0	COG0826@1|root,COG0826@2|Bacteria,1MUQG@1224|Proteobacteria,42M8P@68525|delta/epsilon subdivisions,2WMKS@28221|Deltaproteobacteria,2YWJ3@29|Myxococcales	28221|Deltaproteobacteria	O	Collagenase	-	-	-	ko:K08303	ko05120,map05120	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	DUF3656,Peptidase_U32
HKD2_k127_6573738_3	448385.sce2261	4.877e-61	225.0	COG0642@1|root,COG2205@2|Bacteria,1QXTM@1224|Proteobacteria,43C5Z@68525|delta/epsilon subdivisions,2X7G8@28221|Deltaproteobacteria,2YXZQ@29|Myxococcales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_4
HKD2_k127_6573738_0	1192034.CAP_8124	0.0	1502.0	COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,42NCZ@68525|delta/epsilon subdivisions,2WK3X@28221|Deltaproteobacteria,2YUB0@29|Myxococcales	28221|Deltaproteobacteria	P	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K07787	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4	-	iAF987.Gmet_1547	ACR_tran
HKD2_k127_6573738_1	1192034.CAP_8125	6.455e-89	327.0	COG0845@1|root,COG0845@2|Bacteria,1MVAS@1224|Proteobacteria,42PKU@68525|delta/epsilon subdivisions,2WM5K@28221|Deltaproteobacteria,2YZUC@29|Myxococcales	28221|Deltaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K07798	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4,8.A.1	-	-	DUF3347,HlyD_D23
HKD2_k127_6573738_4	1142394.PSMK_22540	7.471e-17	93.0	COG1538@1|root,COG1538@2|Bacteria,2IZPU@203682|Planctomycetes	203682|Planctomycetes	MU	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
HKD2_k127_6573738_2	1254432.SCE1572_36820	4.204e-78	269.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,42M8F@68525|delta/epsilon subdivisions,2WIU0@28221|Deltaproteobacteria,2YXKV@29|Myxococcales	28221|Deltaproteobacteria	P	Cation transporter/ATPase, N-terminus	-	-	3.6.3.2	ko:K01531,ko:K12955	-	-	-	-	ko00000,ko01000	3.A.3.24,3.A.3.4	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
HKD2_k127_6584656_1	319236.JCM19294_1975	3.16e-33	134.0	COG1696@1|root,COG1696@2|Bacteria,4NFK5@976|Bacteroidetes,1HWM1@117743|Flavobacteriia,3HKWI@363408|Nonlabens	976|Bacteroidetes	M	MBOAT, membrane-bound O-acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	MBOAT
HKD2_k127_6584656_0	1254432.SCE1572_40650	1.224e-48	184.0	2DRNJ@1|root,33CDI@2|Bacteria,1RGN0@1224|Proteobacteria,42X09@68525|delta/epsilon subdivisions,2WSW8@28221|Deltaproteobacteria,2Z1BH@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6588187_0	448385.sce5787	5.129e-99	339.0	COG0285@1|root,COG0285@2|Bacteria,1MVCH@1224|Proteobacteria,42N08@68525|delta/epsilon subdivisions,2WIW9@28221|Deltaproteobacteria,2YUTG@29|Myxococcales	28221|Deltaproteobacteria	H	Belongs to the folylpolyglutamate synthase family	folC	-	6.3.2.12,6.3.2.17	ko:K11754	ko00790,ko01100,map00790,map01100	M00126,M00841	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2475	Mur_ligase_C,Mur_ligase_M
HKD2_k127_6588187_1	224914.BMEI2020	1.024e-17	83.0	COG0777@1|root,COG0777@2|Bacteria,1MW8G@1224|Proteobacteria,2TRSH@28211|Alphaproteobacteria,1J26U@118882|Brucellaceae	28211|Alphaproteobacteria	F	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA	accD	-	2.1.3.15,6.4.1.2	ko:K01963	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
HKD2_k127_6600593_2	631454.N177_3603	6.876e-43	162.0	COG0708@1|root,COG0708@2|Bacteria,1MVII@1224|Proteobacteria,2TR5J@28211|Alphaproteobacteria,1JN5F@119043|Rhodobiaceae	28211|Alphaproteobacteria	L	Endonuclease/Exonuclease/phosphatase family	xth	-	3.1.11.2	ko:K01142	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exo_endo_phos
HKD2_k127_6600593_1	63737.Npun_F2346	7.921e-120	403.0	COG0642@1|root,COG0745@1|root,COG3609@1|root,COG0745@2|Bacteria,COG2205@2|Bacteria,COG3609@2|Bacteria,1G09B@1117|Cyanobacteria,1HIE5@1161|Nostocales	1117|Cyanobacteria	T	PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg
HKD2_k127_6600593_3	1340493.JNIF01000004_gene1114	1.095e-36	145.0	COG1398@1|root,COG1398@2|Bacteria	2|Bacteria	I	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water	desC	-	1.14.19.1	ko:K00507	ko01040,ko01212,ko03320,ko04152,ko04212,map01040,map01212,map03320,map04152,map04212	-	R02222	RC00917	ko00000,ko00001,ko01000,ko01004	-	-	-	FA_desaturase
HKD2_k127_6600593_0	1144275.COCOR_00432	4.9e-181	573.0	COG0667@1|root,COG0667@2|Bacteria,1MV2Y@1224|Proteobacteria,43475@68525|delta/epsilon subdivisions,2X27R@28221|Deltaproteobacteria,2YXCB@29|Myxococcales	28221|Deltaproteobacteria	C	Aldo/keto reductase family	mocA	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
HKD2_k127_6600593_4	756883.Halar_0715	1.648e-29	127.0	COG3372@1|root,arCOG04356@2157|Archaea	2157|Archaea	S	Protein of unknown function (DUF790)	-	-	-	ko:K09744	-	-	-	-	ko00000	-	-	-	DUF790
HKD2_k127_6607640_5	1132442.KB889752_gene971	1.953e-05	56.0	COG1409@1|root,COG1409@2|Bacteria,1VTEB@1239|Firmicutes	1239|Firmicutes	S	Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
HKD2_k127_6607640_2	1121481.AUAS01000017_gene2505	4.819e-07	59.0	COG3509@1|root,COG3509@2|Bacteria,4NENB@976|Bacteroidetes,47NBX@768503|Cytophagia	976|Bacteroidetes	Q	Carbohydrate family 9 binding domain-like	-	-	-	-	-	-	-	-	-	-	-	-	CBM9_1
HKD2_k127_6607640_0	1173026.Glo7428_0554	4.527e-23	104.0	COG2940@1|root,COG2940@2|Bacteria	2|Bacteria	K	SET domain	-	-	-	ko:K07117	-	-	-	-	ko00000	-	-	-	SET
HKD2_k127_6607640_3	404589.Anae109_0494	7.753e-06	57.0	2A107@1|root,30P5K@2|Bacteria,1QBFU@1224|Proteobacteria,435GC@68525|delta/epsilon subdivisions,2WZTV@28221|Deltaproteobacteria,2Z2QW@29|Myxococcales	28221|Deltaproteobacteria	S	Cysteine-rich CPXCG	-	-	-	-	-	-	-	-	-	-	-	-	Cys_rich_CPXG
HKD2_k127_6607640_1	543632.JOJL01000027_gene2812	3.321e-08	63.0	COG3250@1|root,COG3250@2|Bacteria,2I3FI@201174|Actinobacteria,4D8ZJ@85008|Micromonosporales	201174|Actinobacteria	G	Bacterial alpha-L-rhamnosidase C-terminal domain	-	-	3.2.1.40	ko:K05989	-	-	-	-	ko00000,ko01000	-	-	-	Bac_rhamnosid,Bac_rhamnosid6H,Bac_rhamnosid_C,Bac_rhamnosid_N,BetaGal_dom4_5
HKD2_k127_6608324_0	448385.sce0368	1.374e-136	445.0	COG0247@1|root,COG0247@2|Bacteria,1MUMH@1224|Proteobacteria,42MIV@68525|delta/epsilon subdivisions,2WJ5X@28221|Deltaproteobacteria,2YUAI@29|Myxococcales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8,Fer4_9
HKD2_k127_6608324_1	395964.KE386496_gene958	9.449e-22	98.0	COG3324@1|root,COG3324@2|Bacteria,1R81W@1224|Proteobacteria,2U6BE@28211|Alphaproteobacteria,3NBSY@45404|Beijerinckiaceae	28211|Alphaproteobacteria	S	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	ko:K06996	-	-	-	-	ko00000	-	-	-	Glyoxalase
HKD2_k127_6615070_2	107635.AZUO01000001_gene3043	8.109e-78	273.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,2TQTG@28211|Alphaproteobacteria,36XTN@31993|Methylocystaceae	28211|Alphaproteobacteria	E	B12 binding domain	metH	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006464,GO:0006479,GO:0006520,GO:0006555,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008213,GO:0008270,GO:0008276,GO:0008652,GO:0008705,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0019538,GO:0019752,GO:0019842,GO:0031419,GO:0032259,GO:0034641,GO:0035999,GO:0036094,GO:0036211,GO:0042084,GO:0042558,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046872,GO:0046906,GO:0046914,GO:0048037,GO:0050667,GO:0051186,GO:0071704,GO:0097159,GO:0140096,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
HKD2_k127_6615070_1	391625.PPSIR1_04828	3.522e-87	297.0	COG0500@1|root,COG0640@1|root,COG0640@2|Bacteria,COG2226@2|Bacteria,1NFSV@1224|Proteobacteria,42SU3@68525|delta/epsilon subdivisions,2WP9X@28221|Deltaproteobacteria,2YVJF@29|Myxococcales	28221|Deltaproteobacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5,Methyltransf_11
HKD2_k127_6615070_4	1254432.SCE1572_33480	8.094e-44	170.0	COG3315@1|root,COG3315@2|Bacteria,1REBR@1224|Proteobacteria,42W2V@68525|delta/epsilon subdivisions,2WRPW@28221|Deltaproteobacteria,2YXRE@29|Myxococcales	28221|Deltaproteobacteria	H	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	LCM
HKD2_k127_6615070_3	118166.JH976537_gene3039	1.07e-45	176.0	COG0393@1|root,COG0393@2|Bacteria,1GCDH@1117|Cyanobacteria	1117|Cyanobacteria	S	Putative heavy-metal-binding	-	-	-	-	-	-	-	-	-	-	-	-	YbjQ_1
HKD2_k127_6615070_0	1183438.GKIL_3494	3.168e-96	336.0	COG0393@1|root,COG0393@2|Bacteria,1GC92@1117|Cyanobacteria	1117|Cyanobacteria	S	Putative heavy-metal-binding	-	-	-	-	-	-	-	-	-	-	-	-	YbjQ_1
HKD2_k127_6625895_2	1162668.LFE_0929	8.454e-97	335.0	COG0841@1|root,COG0841@2|Bacteria,3J0ZG@40117|Nitrospirae	40117|Nitrospirae	V	AcrB/AcrD/AcrF family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
HKD2_k127_6625895_8	196367.JNFG01000014_gene5345	5.369e-22	109.0	COG0845@1|root,COG0845@2|Bacteria,1RGVI@1224|Proteobacteria,2WEMG@28216|Betaproteobacteria,1K3FZ@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Barrel-sandwich domain of CusB or HlyD membrane-fusion	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
HKD2_k127_6625895_9	1192034.CAP_5403	1.054e-16	87.0	COG0589@1|root,COG0589@2|Bacteria	2|Bacteria	T	AMP binding	uspA4	GO:0008150,GO:0040007	-	-	-	-	-	-	-	-	-	-	Usp
HKD2_k127_6625895_13	3218.PP1S186_60V6.1	2.064e-05	57.0	KOG1225@1|root,KOG1225@2759|Eukaryota	2759|Eukaryota	L	regulation of canonical Wnt signaling pathway involved in osteoblast differentiation	-	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0007154,GO:0007165,GO:0007166,GO:0007224,GO:0007275,GO:0007399,GO:0008037,GO:0008038,GO:0008039,GO:0008150,GO:0008589,GO:0009966,GO:0009967,GO:0009987,GO:0010646,GO:0010647,GO:0022008,GO:0023051,GO:0023052,GO:0023056,GO:0030154,GO:0030182,GO:0031012,GO:0031647,GO:0032501,GO:0032502,GO:0044421,GO:0045880,GO:0048468,GO:0048518,GO:0048522,GO:0048583,GO:0048584,GO:0048666,GO:0048699,GO:0048731,GO:0048856,GO:0048869,GO:0050789,GO:0050794,GO:0050821,GO:0050896,GO:0051716,GO:0065007,GO:0065008	-	ko:K01691,ko:K06252	ko04151,ko04310,ko04510,ko04512,ko05165,ko05206,map04151,map04310,map04510,map04512,map05165,map05206	-	-	-	ko00000,ko00001,ko00536,ko04516	-	-	-	EGF,EGF_2,WIF,hEGF
HKD2_k127_6625895_12	1267535.KB906767_gene11	6.561e-07	56.0	COG0236@1|root,COG0236@2|Bacteria,3Y54V@57723|Acidobacteria	57723|Acidobacteria	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	acpP	-	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
HKD2_k127_6625895_11	1192034.CAP_5403	8.962e-08	62.0	COG0589@1|root,COG0589@2|Bacteria	2|Bacteria	T	AMP binding	uspA4	GO:0008150,GO:0040007	-	-	-	-	-	-	-	-	-	-	Usp
HKD2_k127_6625895_1	387092.NIS_0326	5.167e-207	653.0	COG0446@1|root,COG0446@2|Bacteria,1PWV7@1224|Proteobacteria,42QCM@68525|delta/epsilon subdivisions,2YND4@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	S	COGs COG1252 NADH dehydrogenase FAD-containing subunit	-	-	1.8.5.4	ko:K17218	ko00920,map00920	-	R10152	RC03155	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
HKD2_k127_6625895_0	637390.AFOH01000047_gene1999	6.069e-220	710.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,1RMYC@1236|Gammaproteobacteria,2NBUA@225057|Acidithiobacillales	225057|Acidithiobacillales	P	Cation transporter/ATPase, N-terminus	-	-	3.6.3.6	ko:K01535	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.3.3	-	-	Cation_ATPase_N,E1-E2_ATPase,Hydrolase
HKD2_k127_6625895_5	1479238.JQMZ01000001_gene2231	2.112e-43	169.0	COG0662@1|root,COG0662@2|Bacteria,1NX04@1224|Proteobacteria,2V7B1@28211|Alphaproteobacteria,43ZHR@69657|Hyphomonadaceae	28211|Alphaproteobacteria	G	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6625895_10	1183438.GKIL_3048	4.975e-12	79.0	COG4193@1|root,COG4193@2|Bacteria	2|Bacteria	G	domain, Protein	lytB	-	3.5.1.28	ko:K01447	-	-	R04112	RC00064,RC00141	ko00000,ko01000	-	-	-	Glucosaminidase,PG_binding_1,SH3_3,SH3_8,SLH
HKD2_k127_6625895_3	1206730.BAGA01000079_gene1232	2.557e-76	276.0	COG0367@1|root,COG0367@2|Bacteria,2GJIM@201174|Actinobacteria,4FWZ1@85025|Nocardiaceae	201174|Actinobacteria	E	Asparagine synthase	-	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
HKD2_k127_6625895_4	391625.PPSIR1_06351	7.469e-45	185.0	COG3209@1|root,COG3209@2|Bacteria	2|Bacteria	M	self proteolysis	-	-	-	-	-	-	-	-	-	-	-	-	Flg_new,RHS_repeat
HKD2_k127_6625895_6	262724.TT_C1692	4.165e-25	109.0	COG0589@1|root,COG0589@2|Bacteria,1WJVG@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	T	Universal stress protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD2_k127_6625895_7	1123277.KB893197_gene6107	1.173e-23	113.0	COG0823@1|root,COG0823@2|Bacteria,4NIYK@976|Bacteroidetes,47N0H@768503|Cytophagia	976|Bacteroidetes	U	WD40-like Beta Propeller Repeat	-	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40
HKD2_k127_6625895_14	2850.Phatr54960	7.326e-05	55.0	COG0330@1|root,KOG3083@2759|Eukaryota,2XARM@2836|Bacillariophyta	2836|Bacillariophyta	O	prohibitin homologues	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
HKD2_k127_6635715_1	448385.sce1266	5.93e-56	222.0	COG4826@1|root,COG4826@2|Bacteria,1REGX@1224|Proteobacteria,42T9N@68525|delta/epsilon subdivisions,2WPDB@28221|Deltaproteobacteria,2YV97@29|Myxococcales	28221|Deltaproteobacteria	O	Belongs to the serpin family	-	-	-	ko:K13963	ko05146,map05146	-	-	-	ko00000,ko00001	-	-	-	Serpin
HKD2_k127_6635715_0	1192034.CAP_3119	0.0	1107.0	COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,42MPZ@68525|delta/epsilon subdivisions,2WIR9@28221|Deltaproteobacteria,2YXPT@29|Myxococcales	28221|Deltaproteobacteria	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
HKD2_k127_6637097_2	1192034.CAP_5909	1.074e-131	434.0	COG3291@1|root,COG3291@2|Bacteria,1QEIS@1224|Proteobacteria,4389M@68525|delta/epsilon subdivisions,2X3J1@28221|Deltaproteobacteria,2YWAB@29|Myxococcales	28221|Deltaproteobacteria	S	IgGFc binding protein	-	-	-	-	-	-	-	-	-	-	-	-	IgGFc_binding
HKD2_k127_6637097_7	1173263.Syn7502_03095	1.643e-29	125.0	COG3428@1|root,COG3428@2|Bacteria,1GE7A@1117|Cyanobacteria	1117|Cyanobacteria	S	Bacterial PH domain	-	-	-	-	-	-	-	-	-	-	-	-	bPH_2
HKD2_k127_6637097_4	877455.Metbo_0048	9.088e-73	267.0	COG0477@1|root,arCOG02682@2157|Archaea,2XWP6@28890|Euryarchaeota,23PB6@183925|Methanobacteria	183925|Methanobacteria	G	Sugar (and other) transporter	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6637097_9	1094980.Mpsy_2565	1.09e-09	69.0	arCOG11924@1|root,arCOG11924@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6637097_5	448385.sce6638	3.694e-65	230.0	COG3738@1|root,COG3738@2|Bacteria,1RE1M@1224|Proteobacteria,42SKM@68525|delta/epsilon subdivisions,2WV6M@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Domain of unknown function (DUF1287)	-	-	-	ko:K09974	-	-	-	-	ko00000	-	-	-	DUF1287
HKD2_k127_6637097_3	448385.sce6347	7.507e-98	338.0	COG0668@1|root,COG0668@2|Bacteria,1MW7V@1224|Proteobacteria,42R90@68525|delta/epsilon subdivisions,2WMUJ@28221|Deltaproteobacteria,2YWD8@29|Myxococcales	28221|Deltaproteobacteria	M	Mechanosensitive ion channel	mscS-2	-	-	-	-	-	-	-	-	-	-	-	MS_channel
HKD2_k127_6637097_0	448385.sce8633	5.794e-319	999.0	COG0308@1|root,COG1413@1|root,COG0308@2|Bacteria,COG1413@2|Bacteria,1MUCI@1224|Proteobacteria,42KZI@68525|delta/epsilon subdivisions,2WJ2C@28221|Deltaproteobacteria,2YTZK@29|Myxococcales	28221|Deltaproteobacteria	CE	Peptidase family M1 domain	pepN	-	3.4.11.2	ko:K01256	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	DUF3458,DUF3458_C,HEAT_2,Peptidase_M1
HKD2_k127_6637097_1	861299.J421_0345	1.62e-138	467.0	COG0220@1|root,COG0220@2|Bacteria	2|Bacteria	J	tRNA (guanine-N7-)-methyltransferase activity	-	-	2.1.1.180,2.1.1.33	ko:K03439,ko:K18846	-	-	-	-	ko00000,ko01000,ko01504,ko03009,ko03016	-	-	-	Methyltransf_25,Methyltransf_4
HKD2_k127_6637097_8	1278073.MYSTI_05810	3.311e-10	63.0	2AIX1@1|root,319EP@2|Bacteria,1Q2I0@1224|Proteobacteria,4384V@68525|delta/epsilon subdivisions,2X3EW@28221|Deltaproteobacteria,2YVRV@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6640270_0	1254432.SCE1572_43675	2.23e-147	484.0	COG2885@1|root,COG2885@2|Bacteria,1R7WJ@1224|Proteobacteria,42QJK@68525|delta/epsilon subdivisions,2WJX0@28221|Deltaproteobacteria,2YWI7@29|Myxococcales	28221|Deltaproteobacteria	M	Belongs to the ompA family	-	-	-	-	-	-	-	-	-	-	-	-	OmpA,TSP_3
HKD2_k127_6640270_1	696747.NIES39_A07880	6.517e-06	56.0	COG1413@1|root,COG1413@2|Bacteria,1G233@1117|Cyanobacteria,1H7RE@1150|Oscillatoriales	1117|Cyanobacteria	C	PBS lyase HEAT-like repeat	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,HEAT_PBS
HKD2_k127_6644198_0	448385.sce5798	9.385e-119	387.0	COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,42M5Q@68525|delta/epsilon subdivisions,2WIIX@28221|Deltaproteobacteria,2YU1F@29|Myxococcales	28221|Deltaproteobacteria	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,IF-2,IF2_N
HKD2_k127_6644198_2	471853.Bcav_1513	3.857e-44	179.0	28HIE@1|root,2Z7TW@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6644198_1	756272.Plabr_3373	6.72e-55	204.0	28HIE@1|root,2Z7TW@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6648080_2	296591.Bpro_1156	9.5e-45	168.0	COG1174@1|root,COG1174@2|Bacteria,1MXA1@1224|Proteobacteria,2VMKH@28216|Betaproteobacteria	28216|Betaproteobacteria	P	ABC-type proline glycine betaine transport	-	-	-	ko:K05845,ko:K05846	ko02010,map02010	M00209	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	BPD_transp_1,OpuAC
HKD2_k127_6648080_0	296591.Bpro_1157	3.784e-143	471.0	COG2986@1|root,COG2986@2|Bacteria,1MU6K@1224|Proteobacteria,2VJB1@28216|Betaproteobacteria,4AAID@80864|Comamonadaceae	1224|Proteobacteria	E	Histidine ammonia-lyase	-	-	4.3.1.3	ko:K01745	ko00340,ko01100,map00340,map01100	M00045	R01168	RC00361	ko00000,ko00001,ko00002,ko01000	-	-	-	Lyase_aromatic
HKD2_k127_6648080_1	296591.Bpro_1158	1.42e-83	279.0	COG1732@1|root,COG1732@2|Bacteria,1MV9N@1224|Proteobacteria,2VMNF@28216|Betaproteobacteria	28216|Betaproteobacteria	M	glycine betaine	-	-	-	ko:K05845	ko02010,map02010	M00209	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	OpuAC
HKD2_k127_6653852_0	404589.Anae109_4207	4.324e-124	404.0	COG1060@1|root,COG1427@1|root,COG1060@2|Bacteria,COG1427@2|Bacteria,1MX50@1224|Proteobacteria,42M6U@68525|delta/epsilon subdivisions,2WJ6Y@28221|Deltaproteobacteria,2YZ18@29|Myxococcales	28221|Deltaproteobacteria	H	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)	mqnC	-	1.21.98.1	ko:K11784	ko00130,ko01110,map00130,map01110	-	R08588	RC02329	ko00000,ko00001,ko01000	-	-	-	Radical_SAM
HKD2_k127_6653852_3	290397.Adeh_0370	2.973e-63	233.0	COG0402@1|root,COG0402@2|Bacteria,1MVPA@1224|Proteobacteria,42MJ7@68525|delta/epsilon subdivisions,2WIRS@28221|Deltaproteobacteria	28221|Deltaproteobacteria	F	PFAM amidohydrolase	-	-	3.5.4.40	ko:K20810	ko00130,ko01110,map00130,map01110	-	R10695	RC00477	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
HKD2_k127_6653852_4	504728.K649_00485	1.729e-54	210.0	COG0382@1|root,COG0382@2|Bacteria,1WI4B@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	H	COGs COG0382 4-hydroxybenzoate polyprenyltransferase and related prenyltransferase	-	-	2.5.1.39	ko:K03179	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R05000,R05615	RC00209,RC02895	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
HKD2_k127_6653852_2	1122939.ATUD01000014_gene1105	1.611e-66	232.0	COG3576@1|root,COG3576@2|Bacteria,2GKCF@201174|Actinobacteria,4CT0M@84995|Rubrobacteria	84995|Rubrobacteria	S	Pfam:Pyridox_oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
HKD2_k127_6653852_1	1297742.A176_01381	4.356e-119	389.0	COG0508@1|root,COG0508@2|Bacteria,1Q4SN@1224|Proteobacteria,437G3@68525|delta/epsilon subdivisions,2X2NP@28221|Deltaproteobacteria,2YU1R@29|Myxococcales	28221|Deltaproteobacteria	C	COG0508 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes	-	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh
HKD2_k127_6660982_9	1123376.AUIU01000012_gene1444	4.849e-41	160.0	COG0156@1|root,COG0156@2|Bacteria,3J0XU@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide	-	-	2.3.1.29	ko:K00639	ko00260,map00260	-	R00371	RC00004,RC00394	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
HKD2_k127_6660982_10	247490.KSU1_C1686	1.985e-38	166.0	COG0304@1|root,COG0304@2|Bacteria,2J2GF@203682|Planctomycetes	203682|Planctomycetes	IQ	Beta-ketoacyl synthase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
HKD2_k127_6660982_6	237368.SCABRO_02229	1.112e-100	345.0	COG0304@1|root,COG0304@2|Bacteria,2J1Z9@203682|Planctomycetes	203682|Planctomycetes	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	-	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
HKD2_k127_6660982_2	640511.BC1002_6690	1.484e-151	500.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2WGHZ@28216|Betaproteobacteria,1KG5N@119060|Burkholderiaceae	28216|Betaproteobacteria	IQ	amp-dependent synthetase and ligase	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,Acyltransferase,PP-binding
HKD2_k127_6660982_13	1192034.CAP_5525	6.146e-15	78.0	COG0236@1|root,COG0236@2|Bacteria	2|Bacteria	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	-	-	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
HKD2_k127_6660982_15	1089439.KB902240_gene800	1.112e-10	64.0	COG0236@1|root,COG0236@2|Bacteria	2|Bacteria	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	-	GO:0000035,GO:0000036,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016053,GO:0019637,GO:0019752,GO:0019842,GO:0031177,GO:0032787,GO:0033218,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044620,GO:0046394,GO:0046467,GO:0046493,GO:0048037,GO:0051192,GO:0071704,GO:0072330,GO:0072341,GO:0090407,GO:0140104,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
HKD2_k127_6660982_17	403833.Pmob_0015	1.841e-05	53.0	COG1846@1|root,COG1846@2|Bacteria,2GD94@200918|Thermotogae	200918|Thermotogae	K	PFAM regulatory protein, MarR	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
HKD2_k127_6660982_5	1183438.GKIL_1092	1.113e-120	410.0	COG3975@1|root,COG3975@2|Bacteria,1G0YP@1117|Cyanobacteria	1117|Cyanobacteria	S	protease with the C-terminal PDZ domain	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Peptidase_M61
HKD2_k127_6660982_4	1382359.JIAL01000001_gene859	7.572e-132	437.0	COG3011@1|root,COG3011@2|Bacteria,3Y78A@57723|Acidobacteria,2JKGF@204432|Acidobacteriia	204432|Acidobacteriia	S	Lipase maturation factor	-	-	-	-	-	-	-	-	-	-	-	-	LMF1
HKD2_k127_6660982_3	483219.LILAB_14210	1.546e-145	473.0	28WH1@1|root,2ZIH5@2|Bacteria,1N53T@1224|Proteobacteria,43CXN@68525|delta/epsilon subdivisions,2X85S@28221|Deltaproteobacteria,2YX1G@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6660982_0	521045.Kole_1372	4.823e-217	700.0	COG1884@1|root,COG1884@2|Bacteria,2GBZM@200918|Thermotogae	200918|Thermotogae	I	PFAM Methylmalonyl-CoA mutase	-	-	5.4.99.2	ko:K01848	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	MM_CoA_mutase
HKD2_k127_6660982_12	1192034.CAP_7009	5.856e-21	102.0	COG2919@1|root,COG2919@2|Bacteria,1NM5U@1224|Proteobacteria,42X2K@68525|delta/epsilon subdivisions,2WSPM@28221|Deltaproteobacteria,2YW2R@29|Myxococcales	28221|Deltaproteobacteria	D	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic	divIC	-	-	ko:K05589,ko:K13052	-	-	-	-	ko00000,ko03036	-	-	-	DivIC
HKD2_k127_6660982_7	215803.DB30_4635	9.12e-56	201.0	COG3852@1|root,COG3852@2|Bacteria,1QVPN@1224|Proteobacteria,439G8@68525|delta/epsilon subdivisions,2X4S6@28221|Deltaproteobacteria,2YZH6@29|Myxococcales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
HKD2_k127_6665940_1	448385.sce8152	3.705e-109	356.0	COG0686@1|root,COG0686@2|Bacteria,1QTX1@1224|Proteobacteria,42MSF@68525|delta/epsilon subdivisions,2WKJ5@28221|Deltaproteobacteria,2YU7F@29|Myxococcales	28221|Deltaproteobacteria	C	Belongs to the AlaDH PNT family	ald	-	1.4.1.1	ko:K00259	ko00250,ko00430,ko01100,map00250,map00430,map01100	-	R00396	RC00008	ko00000,ko00001,ko01000	-	-	iAF987.Gmet_1099	AlaDh_PNT_C,AlaDh_PNT_N
HKD2_k127_6665940_3	1041522.MCOL_V216469	3.416e-06	57.0	COG3794@1|root,COG3794@2|Bacteria,2IQAI@201174|Actinobacteria,23AQX@1762|Mycobacteriaceae	201174|Actinobacteria	C	Copper binding proteins, plastocyanin/azurin family	-	-	-	-	-	-	-	-	-	-	-	-	Copper-bind,Cupredoxin_1
HKD2_k127_6665940_0	1192034.CAP_3448	3.49e-127	415.0	COG0167@1|root,COG0167@2|Bacteria,1MU7C@1224|Proteobacteria,42M46@68525|delta/epsilon subdivisions,2WJ7G@28221|Deltaproteobacteria,2YUMI@29|Myxococcales	28221|Deltaproteobacteria	F	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor	pyrD	GO:0003674,GO:0003824,GO:0004152,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016627,GO:0016635,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019856,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046112,GO:0046390,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	1.3.1.14,1.3.5.2	ko:K00254,ko:K02823,ko:K17828	ko00240,ko01100,map00240,map01100	M00051	R01868,R01869	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
HKD2_k127_6665940_2	525904.Tter_2359	6.537e-23	111.0	COG1306@1|root,COG1306@2|Bacteria,2NQXI@2323|unclassified Bacteria	2|Bacteria	S	Putative glycosyl hydrolase domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4015
HKD2_k127_6668985_2	1254432.SCE1572_20875	9.15e-84	286.0	COG3239@1|root,COG3239@2|Bacteria	2|Bacteria	I	unsaturated fatty acid biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	FA_desaturase
HKD2_k127_6668985_4	246197.MXAN_1633	3.322e-57	205.0	COG1670@1|root,COG1670@2|Bacteria,1RKT9@1224|Proteobacteria,42VCK@68525|delta/epsilon subdivisions,2WS7R@28221|Deltaproteobacteria,2Z14V@29|Myxococcales	28221|Deltaproteobacteria	J	Acetyltransferase (GNAT) domain	rimJ2	-	-	ko:K03817	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_3
HKD2_k127_6668985_1	330214.NIDE1574	1.053e-100	347.0	COG2896@1|root,COG2896@2|Bacteria,3J0PB@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	-	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_14,Mob_synth_C,Radical_SAM
HKD2_k127_6668985_5	404589.Anae109_4087	6.841e-25	110.0	COG0589@1|root,COG0589@2|Bacteria,1RA7K@1224|Proteobacteria,42V2P@68525|delta/epsilon subdivisions,2WRFB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Universal stress protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD2_k127_6668985_7	468556.AQYG01000049_gene976	6.404e-05	56.0	COG1020@1|root,COG1020@2|Bacteria,2GISR@201174|Actinobacteria,4GA3V@85026|Gordoniaceae	201174|Actinobacteria	Q	Condensation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
HKD2_k127_6668985_0	215803.DB30_3254	1.745e-125	425.0	COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,438S3@68525|delta/epsilon subdivisions,2X3YW@28221|Deltaproteobacteria,2YXN3@29|Myxococcales	28221|Deltaproteobacteria	T	GAF domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA
HKD2_k127_6668985_3	1122604.JONR01000015_gene198	2.336e-71	241.0	COG0183@1|root,COG0183@2|Bacteria,1MU8C@1224|Proteobacteria,1RNDU@1236|Gammaproteobacteria,1X9PD@135614|Xanthomonadales	135614|Xanthomonadales	I	Thiolase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Thiolase_C,Thiolase_N
HKD2_k127_6671346_9	639030.JHVA01000001_gene1322	2.986e-36	143.0	COG0465@1|root,COG0465@2|Bacteria,3Y2UK@57723|Acidobacteria,2JI9D@204432|Acidobacteriia	204432|Acidobacteriia	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
HKD2_k127_6671346_12	1192034.CAP_0015	1.194e-05	56.0	COG3215@1|root,COG3215@2|Bacteria,1QASH@1224|Proteobacteria,4359S@68525|delta/epsilon subdivisions,2X978@28221|Deltaproteobacteria,2Z2CF@29|Myxococcales	28221|Deltaproteobacteria	NU	PilZ domain	-	-	-	-	-	-	-	-	-	-	-	-	PilZ
HKD2_k127_6671346_5	1123255.JHYS01000016_gene1087	8.215e-93	320.0	COG2199@1|root,COG2703@1|root,COG2703@2|Bacteria,COG3706@2|Bacteria,1R592@1224|Proteobacteria,2WF2G@28216|Betaproteobacteria,4AES3@80864|Comamonadaceae	28216|Betaproteobacteria	PT	Hemerythrin HHE cation binding domain	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,Hemerythrin
HKD2_k127_6671346_10	391625.PPSIR1_05503	8.066e-19	91.0	COG0517@1|root,COG0517@2|Bacteria,1N68U@1224|Proteobacteria,42UEN@68525|delta/epsilon subdivisions,2X9VF@28221|Deltaproteobacteria,2YVE6@29|Myxococcales	28221|Deltaproteobacteria	K	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
HKD2_k127_6671346_1	706587.Desti_1404	2.28e-158	533.0	COG0784@1|root,COG2202@1|root,COG4191@1|root,COG5000@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG4191@2|Bacteria,COG5000@2|Bacteria,1RCM9@1224|Proteobacteria,42M1R@68525|delta/epsilon subdivisions,2WK3J@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg,SBP_bac_3
HKD2_k127_6671346_7	1192034.CAP_4258	1.347e-60	230.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,439AS@68525|delta/epsilon subdivisions,2X4IF@28221|Deltaproteobacteria,2YZ31@29|Myxococcales	28221|Deltaproteobacteria	KLT	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase,Response_reg
HKD2_k127_6671346_3	118166.JH976538_gene5057	7.352e-110	383.0	COG4191@1|root,COG4191@2|Bacteria,1G1PE@1117|Cyanobacteria,1H8US@1150|Oscillatoriales	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3,PAS_4,PAS_8,Response_reg
HKD2_k127_6671346_11	1116232.AHBF01000034_gene4912	7.257e-10	68.0	2FG3N@1|root,34806@2|Bacteria,2I9A7@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M10
HKD2_k127_6671346_8	483219.LILAB_30980	1.191e-45	182.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,42MVV@68525|delta/epsilon subdivisions	1224|Proteobacteria	KLT	Family membership	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PP2C_2,Pkinase
HKD2_k127_6671346_4	391625.PPSIR1_34113	2.632e-94	322.0	COG2200@1|root,COG2204@1|root,COG2200@2|Bacteria,COG2204@2|Bacteria,1MVJY@1224|Proteobacteria,42S4U@68525|delta/epsilon subdivisions,2WTJ9@28221|Deltaproteobacteria,2Z1P1@29|Myxococcales	28221|Deltaproteobacteria	T	EAL domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL
HKD2_k127_6671346_0	1254432.SCE1572_29010	2.008e-161	514.0	COG0057@1|root,COG0057@2|Bacteria,1MU93@1224|Proteobacteria,42N9Q@68525|delta/epsilon subdivisions,2WIK1@28221|Deltaproteobacteria,2YUMG@29|Myxococcales	28221|Deltaproteobacteria	C	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family	gapA	-	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Gp_dh_C,Gp_dh_N
HKD2_k127_6671346_2	1192034.CAP_5781	8.914e-156	502.0	COG0126@1|root,COG0126@2|Bacteria,1MUNU@1224|Proteobacteria,42N4P@68525|delta/epsilon subdivisions,2WJ0B@28221|Deltaproteobacteria,2YTW5@29|Myxococcales	28221|Deltaproteobacteria	F	Belongs to the phosphoglycerate kinase family	pgk	-	2.7.2.3	ko:K00927	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01512	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
HKD2_k127_6671346_6	1192034.CAP_5780	3.487e-80	291.0	COG0149@1|root,COG0149@2|Bacteria,1MWK5@1224|Proteobacteria,42MIF@68525|delta/epsilon subdivisions,2WIQF@28221|Deltaproteobacteria,2YU88@29|Myxococcales	28221|Deltaproteobacteria	G	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)	tpiA	-	5.3.1.1	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01015	RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	TIM
HKD2_k127_6677003_2	1150474.JQJI01000008_gene1349	6.491e-17	91.0	COG1409@1|root,COG1409@2|Bacteria,2GDWS@200918|Thermotogae	200918|Thermotogae	S	Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
HKD2_k127_6677003_1	448385.sce2235	9.551e-56	205.0	COG0515@1|root,COG0515@2|Bacteria	448385.sce2235|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6677003_3	760192.Halhy_1524	3.728e-16	87.0	COG4888@1|root,COG4888@2|Bacteria,4NEE8@976|Bacteroidetes	976|Bacteroidetes	S	PFAM ASPIC and UnbV	-	-	-	-	-	-	-	-	-	-	-	-	UnbV_ASPIC,VCBS
HKD2_k127_6679385_4	1254432.SCE1572_04615	1.075e-12	70.0	COG0003@1|root,COG0003@2|Bacteria,1MUTX@1224|Proteobacteria,42MT4@68525|delta/epsilon subdivisions,2WKZD@28221|Deltaproteobacteria,2Z34N@29|Myxococcales	28221|Deltaproteobacteria	D	AAA domain	-	-	3.6.3.16	ko:K01551	-	-	-	-	ko00000,ko01000,ko02000	3.A.19.1,3.A.21.1,3.A.4.1	-	-	ArsA_ATPase
HKD2_k127_6679385_1	502025.Hoch_2835	5.514e-119	390.0	COG0346@1|root,COG0394@1|root,COG0346@2|Bacteria,COG0394@2|Bacteria,1MWYQ@1224|Proteobacteria,42SQK@68525|delta/epsilon subdivisions,2WPK1@28221|Deltaproteobacteria,2Z32Z@29|Myxococcales	28221|Deltaproteobacteria	T	PFAM Protein-tyrosine phosphatase, low molecular weight	-	-	1.20.4.1	ko:K03741	-	-	-	-	ko00000,ko01000	-	-	-	LMWPc
HKD2_k127_6679385_0	903818.KI912268_gene1769	2.584e-164	522.0	COG0798@1|root,COG0798@2|Bacteria,3Y431@57723|Acidobacteria	57723|Acidobacteria	P	Sodium Bile acid symporter family	-	-	-	ko:K03325	-	-	-	-	ko00000,ko02000	2.A.59	-	-	SBF
HKD2_k127_6679385_2	82508.K1VSZ6	2.475e-99	332.0	KOG1037@1|root,KOG1037@2759|Eukaryota,38Y0Z@33154|Opisthokonta,3Q0Y1@4751|Fungi,3VAGH@5204|Basidiomycota,3VH3D@5234|Tremellales	4751|Fungi	H	O-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
HKD2_k127_6679385_3	1254432.SCE1572_40405	4.739e-29	120.0	COG0640@1|root,COG0640@2|Bacteria,1PHXH@1224|Proteobacteria,431QB@68525|delta/epsilon subdivisions,2WW8I@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	HTH_20
HKD2_k127_6680411_1	1254432.SCE1572_46050	7.017e-144	464.0	COG1305@1|root,COG1305@2|Bacteria,1R5BE@1224|Proteobacteria,4339F@68525|delta/epsilon subdivisions,2WYFR@28221|Deltaproteobacteria,2YTXM@29|Myxococcales	28221|Deltaproteobacteria	E	Domain of Unknown Function with PDB structure (DUF3857)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3857,Transglut_core
HKD2_k127_6696167_6	1254432.SCE1572_18180	6.343e-19	87.0	COG0848@1|root,COG0848@2|Bacteria,1NA7P@1224|Proteobacteria,42V1Q@68525|delta/epsilon subdivisions,2WSGW@28221|Deltaproteobacteria,2YY8R@29|Myxococcales	28221|Deltaproteobacteria	U	Biopolymer transport protein ExbD/TolR	-	-	-	-	-	-	-	-	-	-	-	-	ExbD
HKD2_k127_6696167_4	345341.KUTG_07083	4.065e-37	143.0	COG0640@1|root,COG0640@2|Bacteria,2IQQU@201174|Actinobacteria,4E6MK@85010|Pseudonocardiales	201174|Actinobacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
HKD2_k127_6696167_3	1380391.JIAS01000015_gene316	3.238e-39	156.0	COG3832@1|root,COG3832@2|Bacteria,1RJJY@1224|Proteobacteria,2U9FZ@28211|Alphaproteobacteria,2JU5H@204441|Rhodospirillales	204441|Rhodospirillales	S	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
HKD2_k127_6696167_1	1254432.SCE1572_14555	1.46e-145	502.0	COG0772@1|root,COG0772@2|Bacteria,1MUK3@1224|Proteobacteria,42MQT@68525|delta/epsilon subdivisions,2WIP1@28221|Deltaproteobacteria,2YUT8@29|Myxococcales	28221|Deltaproteobacteria	D	Belongs to the SEDS family	mrdB	-	-	ko:K05837	-	-	-	-	ko00000,ko03036	-	-	-	FTSW_RODA_SPOVE
HKD2_k127_6696167_0	1254432.SCE1572_14550	5.046e-210	683.0	COG0768@1|root,COG0768@2|Bacteria,1MV8C@1224|Proteobacteria,42M1S@68525|delta/epsilon subdivisions,2WJ02@28221|Deltaproteobacteria,2YU5Y@29|Myxococcales	28221|Deltaproteobacteria	M	Penicillin-binding Protein dimerisation domain	mrdA	-	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	iAF987.Gmet_0928	PBP_dimer,Transpeptidase
HKD2_k127_6696167_5	1192034.CAP_7534	6.937e-36	140.0	COG1792@1|root,COG1792@2|Bacteria,1N8ZS@1224|Proteobacteria,42S9I@68525|delta/epsilon subdivisions,2WNTW@28221|Deltaproteobacteria,2YVI1@29|Myxococcales	28221|Deltaproteobacteria	M	Involved in formation and maintenance of cell shape	mreC	-	-	ko:K03570	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreC
HKD2_k127_6702914_1	1254432.SCE1572_42075	8.75e-74	252.0	COG2255@1|root,COG2255@2|Bacteria,1MU38@1224|Proteobacteria,42M99@68525|delta/epsilon subdivisions,2WJ2Q@28221|Deltaproteobacteria,2YUGW@29|Myxococcales	28221|Deltaproteobacteria	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing	ruvB	-	3.6.4.12	ko:K03551	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvB_C,RuvB_N
HKD2_k127_6702914_0	448385.sce7217	1.884e-156	504.0	COG0745@1|root,COG2202@1|root,COG2203@1|root,COG5002@1|root,COG0745@2|Bacteria,COG2202@2|Bacteria,COG2203@2|Bacteria,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,43CW5@68525|delta/epsilon subdivisions,2X845@28221|Deltaproteobacteria,2Z3KI@29|Myxococcales	28221|Deltaproteobacteria	KT	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HisKA,PAS,Response_reg
HKD2_k127_6704275_0	861299.J421_3612	1.727e-92	317.0	COG0531@1|root,COG0531@2|Bacteria,1ZT2B@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	C-terminus of AA_permease	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
HKD2_k127_6704275_1	215803.DB30_5720	5.812e-80	291.0	COG0784@1|root,COG1716@1|root,COG2202@1|root,COG4191@1|root,COG0784@2|Bacteria,COG1716@2|Bacteria,COG2202@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42PGC@68525|delta/epsilon subdivisions,2WKHK@28221|Deltaproteobacteria,2Z2WB@29|Myxococcales	28221|Deltaproteobacteria	T	Forkhead associated domain	-	-	-	-	-	-	-	-	-	-	-	-	FHA,HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg,dCache_3
HKD2_k127_6707188_4	1220534.B655_1034	4.735e-52	198.0	COG1032@1|root,arCOG01356@2157|Archaea	2157|Archaea	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
HKD2_k127_6707188_5	1192034.CAP_2909	6.005e-49	188.0	COG2370@1|root,COG2370@2|Bacteria,1MV6Z@1224|Proteobacteria,42SSE@68525|delta/epsilon subdivisions,2X5RE@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	HupE / UreJ protein	-	-	-	-	-	-	-	-	-	-	-	-	HupE_UreJ_2
HKD2_k127_6707188_1	1254432.SCE1572_21745	1.645e-128	437.0	COG1520@1|root,COG1520@2|Bacteria,1MXIJ@1224|Proteobacteria,42V3F@68525|delta/epsilon subdivisions,2WR8K@28221|Deltaproteobacteria,2YVGH@29|Myxococcales	28221|Deltaproteobacteria	S	PQQ enzyme repeat	yfgL	-	-	ko:K17713	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	PQQ_2,PQQ_3
HKD2_k127_6707188_6	1254432.SCE1572_21750	4.381e-40	172.0	COG0457@1|root,COG0457@2|Bacteria,1N8F7@1224|Proteobacteria,42VYY@68525|delta/epsilon subdivisions,2WSH2@28221|Deltaproteobacteria,2YW0E@29|Myxococcales	28221|Deltaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_21,TPR_6,TPR_8
HKD2_k127_6707188_0	1254432.SCE1572_21755	1.298e-208	681.0	COG1413@1|root,COG3119@1|root,COG1413@2|Bacteria,COG3119@2|Bacteria,1MWY7@1224|Proteobacteria,42V1G@68525|delta/epsilon subdivisions,2WRCZ@28221|Deltaproteobacteria,2YWCA@29|Myxococcales	28221|Deltaproteobacteria	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
HKD2_k127_6707188_2	1254432.SCE1572_15130	2.397e-102	341.0	COG2230@1|root,COG2230@2|Bacteria,1MX3U@1224|Proteobacteria,42PB7@68525|delta/epsilon subdivisions,2WJX5@28221|Deltaproteobacteria,2Z1H2@29|Myxococcales	28221|Deltaproteobacteria	M	Mycolic acid cyclopropane synthetase	cfa1	-	2.1.1.317,2.1.1.79	ko:K00574,ko:K20238	-	-	-	-	ko00000,ko01000	-	-	iAF987.Gmet_2187	CMAS
HKD2_k127_6707188_3	1192034.CAP_7926	3.955e-59	208.0	COG0782@1|root,COG0782@2|Bacteria,1RCXW@1224|Proteobacteria,42SDX@68525|delta/epsilon subdivisions,2WP41@28221|Deltaproteobacteria,2YV5G@29|Myxococcales	28221|Deltaproteobacteria	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides	greA	-	-	ko:K03624	-	-	-	-	ko00000,ko03021	-	-	-	GreA_GreB,GreA_GreB_N
HKD2_k127_6707541_0	391625.PPSIR1_12533	9.772e-169	537.0	COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,42ZCI@68525|delta/epsilon subdivisions,2X7VD@28221|Deltaproteobacteria,2YZNM@29|Myxococcales	28221|Deltaproteobacteria	H	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.55	ko:K15372	ko00410,ko00430,ko01100,map00410,map00430,map01100	-	R00908,R01684	RC00006,RC00062	ko00000,ko00001,ko01000	-	-	-	Aminotran_3
HKD2_k127_6707541_4	706587.Desti_1336	6.44e-32	141.0	COG2771@1|root,COG2771@2|Bacteria,1NAK1@1224|Proteobacteria,42VEJ@68525|delta/epsilon subdivisions,2WS0Q@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	Protein of unknown function (DUF4019)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4019
HKD2_k127_6707541_2	448385.sce0947	1.591e-64	246.0	COG4251@1|root,COG4251@2|Bacteria,1N0FI@1224|Proteobacteria,438UR@68525|delta/epsilon subdivisions,2X9J0@28221|Deltaproteobacteria,2YXU1@29|Myxococcales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
HKD2_k127_6707541_5	448385.sce0429	1.686e-19	93.0	COG0745@1|root,COG0745@2|Bacteria,1NBDV@1224|Proteobacteria,42UVC@68525|delta/epsilon subdivisions,2WQ45@28221|Deltaproteobacteria,2Z1WY@29|Myxococcales	28221|Deltaproteobacteria	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
HKD2_k127_6707541_1	667632.KB890182_gene876	2.08e-83	297.0	COG1520@1|root,COG1520@2|Bacteria,1NDU1@1224|Proteobacteria,2WBCG@28216|Betaproteobacteria,1K4V0@119060|Burkholderiaceae	1224|Proteobacteria	S	Pyrrolo-quinoline quinone	-	-	-	-	-	-	-	-	-	-	-	-	PQQ,PQQ_3
HKD2_k127_6707541_6	1042377.AFPJ01000009_gene308	3.959e-18	96.0	2FEBM@1|root,346BC@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6707541_3	215803.DB30_3755	1.226e-45	171.0	COG0454@1|root,COG0456@2|Bacteria,1N2EC@1224|Proteobacteria,437FF@68525|delta/epsilon subdivisions,2X2N2@28221|Deltaproteobacteria,2YZX8@29|Myxococcales	28221|Deltaproteobacteria	K	FR47-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HKD2_k127_6707774_0	1254432.SCE1572_43805	5.177e-83	286.0	COG1651@1|root,COG1651@2|Bacteria,1PFNH@1224|Proteobacteria,434F2@68525|delta/epsilon subdivisions,2X8UX@28221|Deltaproteobacteria,2Z0HJ@29|Myxococcales	28221|Deltaproteobacteria	O	Thioredoxin	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_4
HKD2_k127_6707774_1	1254432.SCE1572_43800	6.846e-80	289.0	COG0847@1|root,COG0847@2|Bacteria	2|Bacteria	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease	-	-	2.7.7.7	ko:K02342,ko:K10857	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	RNase_T
HKD2_k127_6707774_3	246197.MXAN_5247	6.086e-08	62.0	COG3507@1|root,COG3507@2|Bacteria,1R5F2@1224|Proteobacteria,43E6V@68525|delta/epsilon subdivisions,2X7I1@28221|Deltaproteobacteria,2YZ3Q@29|Myxococcales	28221|Deltaproteobacteria	G	Glycosyl hydrolases family 43	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_43
HKD2_k127_6707774_2	483219.LILAB_34145	6.024e-21	96.0	COG3507@1|root,COG3507@2|Bacteria,1R5F2@1224|Proteobacteria,43E6V@68525|delta/epsilon subdivisions,2X7I1@28221|Deltaproteobacteria,2YZ3Q@29|Myxococcales	28221|Deltaproteobacteria	G	Glycosyl hydrolases family 43	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_43
HKD2_k127_6712642_0	1192034.CAP_2593	2.087e-138	455.0	COG0318@1|root,COG0318@2|Bacteria,1PG0N@1224|Proteobacteria,42ZGH@68525|delta/epsilon subdivisions,2WUZC@28221|Deltaproteobacteria,2YXZH@29|Myxococcales	28221|Deltaproteobacteria	IQ	AMP-binding enzyme C-terminal domain	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
HKD2_k127_6712642_1	448385.sce5854	8.418e-10	59.0	COG3215@1|root,COG3215@2|Bacteria,1Q2S4@1224|Proteobacteria,43266@68525|delta/epsilon subdivisions,2WXR8@28221|Deltaproteobacteria,2YVFJ@29|Myxococcales	28221|Deltaproteobacteria	NU	PilZ domain	-	-	-	ko:K02676	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilZ
HKD2_k127_6734440_3	448385.sce4487	1.049e-48	176.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,42RC9@68525|delta/epsilon subdivisions,2WN5U@28221|Deltaproteobacteria,2YWJ8@29|Myxococcales	28221|Deltaproteobacteria	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HKD2_k127_6734440_5	1173263.Syn7502_00147	5.086e-08	61.0	2AEZS@1|root,314XV@2|Bacteria,1G6SM@1117|Cyanobacteria,1H14Q@1129|Synechococcus	1117|Cyanobacteria	S	Putative bacterial sensory transduction regulator	-	-	-	-	-	-	-	-	-	-	-	-	YbjN
HKD2_k127_6734440_1	1254432.SCE1572_17715	2.107e-112	381.0	2AIWV@1|root,319EH@2|Bacteria,1Q2HT@1224|Proteobacteria,433TN@68525|delta/epsilon subdivisions,2X3EP@28221|Deltaproteobacteria,2YVQT@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6734440_0	1254432.SCE1572_17710	1.549e-136	458.0	COG3303@1|root,COG3303@2|Bacteria,1MYBV@1224|Proteobacteria,42SER@68525|delta/epsilon subdivisions,2WPC2@28221|Deltaproteobacteria,2YUR5@29|Myxococcales	28221|Deltaproteobacteria	C	Cytochrome c7 and related cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C7
HKD2_k127_6734440_4	1254432.SCE1572_17705	3.843e-34	132.0	2BGQS@1|root,32APS@2|Bacteria,1QAWR@1224|Proteobacteria,43E4J@68525|delta/epsilon subdivisions,2X97X@28221|Deltaproteobacteria,2Z2HF@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6734440_2	1278073.MYSTI_03895	6.428e-57	202.0	COG1716@1|root,COG2199@1|root,COG1716@2|Bacteria,COG3706@2|Bacteria,1MZV7@1224|Proteobacteria,42SA7@68525|delta/epsilon subdivisions,2WNRU@28221|Deltaproteobacteria,2YU91@29|Myxococcales	28221|Deltaproteobacteria	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	FHA,GGDEF,Yop-YscD_cpl
HKD2_k127_6742512_0	448385.sce9193	1.125e-276	867.0	COG0243@1|root,COG0243@2|Bacteria,1NS3T@1224|Proteobacteria,42M9Q@68525|delta/epsilon subdivisions,2X7DH@28221|Deltaproteobacteria,2YUKN@29|Myxococcales	28221|Deltaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Molybdopterin,Molydop_binding
HKD2_k127_6742512_8	1519464.HY22_08985	7.58e-18	87.0	2E6K6@1|root,3316Y@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6742512_5	405948.SACE_1365	1.016e-64	243.0	COG1526@1|root,COG1526@2|Bacteria,2GKWC@201174|Actinobacteria,4DXH8@85010|Pseudonocardiales	201174|Actinobacteria	C	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH	fdhD	-	-	ko:K02379	-	-	-	-	ko00000	-	-	-	FdhD-NarQ
HKD2_k127_6742512_3	1254432.SCE1572_40325	9.666e-72	277.0	COG0457@1|root,COG3903@1|root,COG0457@2|Bacteria,COG3903@2|Bacteria,1MWPD@1224|Proteobacteria,438M3@68525|delta/epsilon subdivisions,2X1ZS@28221|Deltaproteobacteria,2YX8A@29|Myxococcales	28221|Deltaproteobacteria	T	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_22,Guanylate_cyc,TPR_12
HKD2_k127_6742512_9	485913.Krac_4700	4.375e-15	88.0	2DRZ7@1|root,33DSV@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6742512_1	1297742.A176_03265	1.071e-98	339.0	COG0531@1|root,COG0531@2|Bacteria,1MUA2@1224|Proteobacteria,42T8N@68525|delta/epsilon subdivisions,2WZ91@28221|Deltaproteobacteria,2Z1M2@29|Myxococcales	28221|Deltaproteobacteria	E	Amino acid permease	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
HKD2_k127_6742512_6	446462.Amir_1888	5.396e-50	206.0	COG3831@1|root,COG3831@2|Bacteria,2HIEQ@201174|Actinobacteria,4E0XY@85010|Pseudonocardiales	201174|Actinobacteria	MU	Domain of unknown function (DUF4132)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4132,WGR
HKD2_k127_6742512_2	1120949.KB903299_gene5889	1.815e-92	340.0	COG0604@1|root,COG0604@2|Bacteria,2GK40@201174|Actinobacteria,4DH8E@85008|Micromonosporales	201174|Actinobacteria	C	Zinc-binding dehydrogenase	fadB5	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N,ADH_zinc_N_2
HKD2_k127_6742512_4	365046.Rta_20540	1.854e-71	267.0	COG3509@1|root,COG3509@2|Bacteria,1NTIV@1224|Proteobacteria,2VKDX@28216|Betaproteobacteria,4ACW5@80864|Comamonadaceae	28216|Betaproteobacteria	Q	PFAM Fibronectin type III domain protein	phaZ	-	3.1.1.75	ko:K05973	ko00650,map00650	-	R05118	-	ko00000,ko00001,ko01000	-	-	-	Esterase_phd
HKD2_k127_6742512_7	929703.KE386491_gene4014	2.35e-30	122.0	COG0332@1|root,COG0332@2|Bacteria,4NFIN@976|Bacteroidetes,47JAR@768503|Cytophagia	976|Bacteroidetes	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	-	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
HKD2_k127_674522_1	1254432.SCE1572_18890	2.344e-13	70.0	COG3291@1|root,COG3291@2|Bacteria,1R7A1@1224|Proteobacteria,42Y4U@68525|delta/epsilon subdivisions,2WU72@28221|Deltaproteobacteria,2YZXW@29|Myxococcales	28221|Deltaproteobacteria	U	IgGFc binding protein	-	-	-	-	-	-	-	-	-	-	-	-	Big_1,IgGFc_binding
HKD2_k127_674522_2	103690.17129894	8.735e-06	54.0	29WKC@1|root,30I6W@2|Bacteria,1GDBN@1117|Cyanobacteria,1HNA1@1161|Nostocales	1117|Cyanobacteria	S	23S rRNA-intervening sequence protein	-	-	-	-	-	-	-	-	-	-	-	-	23S_rRNA_IVP
HKD2_k127_6745909_3	1121933.AUHH01000009_gene896	4.15e-30	134.0	COG2267@1|root,COG2267@2|Bacteria,2HFM6@201174|Actinobacteria,4DWC5@85009|Propionibacteriales	2|Bacteria	I	carboxylic ester hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
HKD2_k127_6745909_5	1448139.AI20_01450	1.885e-14	83.0	COG0596@1|root,COG0596@2|Bacteria,1RKIV@1224|Proteobacteria,1S4N5@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
HKD2_k127_6745909_2	1313421.JHBV01000016_gene5489	9.291e-82	287.0	COG4942@1|root,COG4942@2|Bacteria	2|Bacteria	D	peptidase	-	-	-	ko:K19304	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	DUF3375
HKD2_k127_6745909_1	404589.Anae109_0529	7.871e-102	359.0	COG0642@1|root,COG0784@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,42M0Y@68525|delta/epsilon subdivisions,2X7MY@28221|Deltaproteobacteria,2YZ0R@29|Myxococcales	28221|Deltaproteobacteria	T	PAS fold	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3,Response_reg
HKD2_k127_6745909_6	1122194.AUHU01000005_gene878	8.8e-10	67.0	COG1309@1|root,COG1309@2|Bacteria,1PFEP@1224|Proteobacteria,1TAD5@1236|Gammaproteobacteria,468XZ@72275|Alteromonadaceae	1236|Gammaproteobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
HKD2_k127_6745909_4	269797.Mbar_A0608	4.92e-24	117.0	COG0535@1|root,arCOG00938@2157|Archaea,2XZ9M@28890|Euryarchaeota,2NANF@224756|Methanomicrobia	224756|Methanomicrobia	S	Radical SAM superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DUF3463,Radical_SAM
HKD2_k127_6745909_0	1297569.MESS2_50083	3.724e-160	548.0	COG0022@1|root,COG1071@1|root,COG0022@2|Bacteria,COG1071@2|Bacteria,1MU5R@1224|Proteobacteria,2TWBA@28211|Alphaproteobacteria,43MU4@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	C	Transketolase, pyrimidine binding domain	-	-	1.2.4.4	ko:K11381,ko:K21416	ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130	M00036	R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00027,RC00627,RC02743,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_lipoyl,E1_dh,Transket_pyr,Transketolase_C
HKD2_k127_6745990_0	1267535.KB906767_gene3488	1.694e-59	219.0	COG2132@1|root,COG2132@2|Bacteria	2|Bacteria	Q	Multicopper oxidase	-	-	1.10.3.4	ko:K20219	ko00380,map00380	-	R00074	RC00767,RC02319	ko00000,ko00001,ko01000	-	-	-	Cu-oxidase_2,Cu-oxidase_3
HKD2_k127_6746089_3	502025.Hoch_4921	8.966e-90	311.0	COG4198@1|root,COG4198@2|Bacteria,1NPPY@1224|Proteobacteria,42NTB@68525|delta/epsilon subdivisions,2WKNX@28221|Deltaproteobacteria,2Z31V@29|Myxococcales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF1015)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1015
HKD2_k127_6746089_0	1158318.ATXC01000001_gene1037	1.15e-125	415.0	COG0151@1|root,COG0151@2|Bacteria,2G3J3@200783|Aquificae	200783|Aquificae	F	Belongs to the GARS family	purD	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	GARS_A,GARS_C,GARS_N
HKD2_k127_6746089_9	246197.MXAN_5804	3.387e-15	86.0	COG0443@1|root,COG0443@2|Bacteria,1MVEN@1224|Proteobacteria,42M64@68525|delta/epsilon subdivisions,2WIWS@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	Heat shock 70 kDa protein	-	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
HKD2_k127_6746089_4	448385.sce3766	4.659e-82	284.0	COG0515@1|root,COG0515@2|Bacteria,1PFJ6@1224|Proteobacteria,4340Z@68525|delta/epsilon subdivisions,2X4J2@28221|Deltaproteobacteria,2YZ45@29|Myxococcales	28221|Deltaproteobacteria	KLT	Protein kinase domain	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
HKD2_k127_6746089_6	1192034.CAP_3086	1.993e-66	250.0	COG0434@1|root,COG0434@2|Bacteria,1Q83B@1224|Proteobacteria,431HE@68525|delta/epsilon subdivisions,2WWQM@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	BtpA family	-	-	-	-	-	-	-	-	-	-	-	-	BtpA
HKD2_k127_6746089_5	448385.sce9208	9.125e-71	260.0	2DRH1@1|root,33BQ8@2|Bacteria,1NM8D@1224|Proteobacteria,42XND@68525|delta/epsilon subdivisions,2WSKN@28221|Deltaproteobacteria,2YW71@29|Myxococcales	28221|Deltaproteobacteria	-	-	gspN	-	-	-	-	-	-	-	-	-	-	-	AsmA_2
HKD2_k127_6746089_2	448385.sce9210	1.006e-112	381.0	COG4972@1|root,COG4972@2|Bacteria,1MYIB@1224|Proteobacteria,42SIX@68525|delta/epsilon subdivisions,2WP1G@28221|Deltaproteobacteria,2YVKD@29|Myxococcales	28221|Deltaproteobacteria	NU	Type IV pilus assembly protein PilM;	gspL	-	-	ko:K02461	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	GspL_C,PilM_2,PilN,T2SSL
HKD2_k127_6746089_1	1192034.CAP_6340	1.467e-113	389.0	COG3156@1|root,COG3156@2|Bacteria,1RIW9@1224|Proteobacteria,42V6H@68525|delta/epsilon subdivisions,2X2BW@28221|Deltaproteobacteria,2YVV7@29|Myxococcales	28221|Deltaproteobacteria	U	Type II secretion system (T2SS), protein K	gspK	-	-	ko:K02460	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSK
HKD2_k127_6746089_7	1254432.SCE1572_51965	2.618e-62	226.0	COG4795@1|root,COG4795@2|Bacteria,1NPEC@1224|Proteobacteria,42WZG@68525|delta/epsilon subdivisions,2WSPB@28221|Deltaproteobacteria,2YVMW@29|Myxococcales	28221|Deltaproteobacteria	U	Type II secretion system (T2SS), protein J	gspJ	-	-	ko:K02459	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl,T2SSJ
HKD2_k127_6746089_10	391625.PPSIR1_25841	0.000108	48.0	COG4967@1|root,COG4967@2|Bacteria,1QUS3@1224|Proteobacteria,42X07@68525|delta/epsilon subdivisions,2WSQI@28221|Deltaproteobacteria,2YW2A@29|Myxococcales	28221|Deltaproteobacteria	U	Prokaryotic N-terminal methylation motif	gspI	-	-	ko:K02458	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl
HKD2_k127_6758108_0	1254432.SCE1572_19010	2.176e-220	690.0	COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,42M9W@68525|delta/epsilon subdivisions,2WJ29@28221|Deltaproteobacteria,2YU3Z@29|Myxococcales	28221|Deltaproteobacteria	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon-2	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
HKD2_k127_6758108_2	1158294.JOMI01000003_gene2785	3.356e-06	49.0	2DRWY@1|root,33DG4@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6758108_1	1049564.TevJSym_bd00030	1.817e-24	109.0	COG3437@1|root,COG3437@2|Bacteria,1P1A3@1224|Proteobacteria,1S1WE@1236|Gammaproteobacteria,1J73M@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
HKD2_k127_6760984_1	448385.sce1572	4.711e-28	120.0	COG2979@1|root,COG2979@2|Bacteria	2|Bacteria	T	Protein of unknown function (DUF533)	-	-	-	ko:K06596	ko02020,ko02025,map02020,map02025	M00507	-	-	ko00000,ko00001,ko00002,ko01001,ko02022,ko02035	-	-	-	PG_binding_4,TerB,VanW
HKD2_k127_6762061_2	1254432.SCE1572_42135	3.942e-97	348.0	COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,42MAR@68525|delta/epsilon subdivisions,2WJEU@28221|Deltaproteobacteria,2YWC8@29|Myxococcales	28221|Deltaproteobacteria	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HKD2_k127_6762061_1	1254432.SCE1572_42130	6.95e-107	362.0	COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,42P96@68525|delta/epsilon subdivisions,2WMVB@28221|Deltaproteobacteria,2YUCK@29|Myxococcales	28221|Deltaproteobacteria	P	Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD2_k127_6762061_0	448385.sce7226	2.65e-126	416.0	COG0845@1|root,COG0845@2|Bacteria,1MU8D@1224|Proteobacteria,42NVA@68525|delta/epsilon subdivisions,2WMQK@28221|Deltaproteobacteria,2YWS4@29|Myxococcales	28221|Deltaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	HlyD_D23
HKD2_k127_6762061_3	1254432.SCE1572_49805	1.401e-74	258.0	COG1595@1|root,COG1595@2|Bacteria,1RKMN@1224|Proteobacteria,431Z5@68525|delta/epsilon subdivisions,2WWH8@28221|Deltaproteobacteria,2Z13Y@29|Myxococcales	28221|Deltaproteobacteria	K	RNA polymerase sigma factor	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD2_k127_6764963_2	391625.PPSIR1_39435	3.109e-09	62.0	COG1331@1|root,COG1331@2|Bacteria,1MUUT@1224|Proteobacteria,43BWP@68525|delta/epsilon subdivisions,2X77H@28221|Deltaproteobacteria,2YXA7@29|Myxococcales	28221|Deltaproteobacteria	O	Protein of unknown function, DUF255	-	-	-	-	-	-	-	-	-	-	-	-	Thioredox_DsbH
HKD2_k127_6764963_4	1206741.BAFX01000187_gene7552	0.0002543	44.0	2BRSW@1|root,32KSX@2|Bacteria,2H8XA@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6764963_3	1415779.JOMH01000001_gene2830	9.805e-05	55.0	COG3391@1|root,COG3391@2|Bacteria,1RJQF@1224|Proteobacteria,1S6KV@1236|Gammaproteobacteria,1XA5K@135614|Xanthomonadales	135614|Xanthomonadales	S	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6764963_0	448385.sce7393	6.912e-128	420.0	COG0452@1|root,COG0452@2|Bacteria,1MVQP@1224|Proteobacteria,42NIG@68525|delta/epsilon subdivisions,2WIR1@28221|Deltaproteobacteria,2YUKH@29|Myxococcales	28221|Deltaproteobacteria	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	coaBC	-	4.1.1.36,6.3.2.5	ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	DFP,Flavoprotein
HKD2_k127_6764963_1	1279009.ADICEAN_01406	5.867e-27	110.0	COG0012@1|root,COG0012@2|Bacteria,4NF7N@976|Bacteroidetes,47KXT@768503|Cytophagia	976|Bacteroidetes	J	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner	ychF	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,YchF-GTPase_C
HKD2_k127_677393_1	1242864.D187_007256	4.266e-84	288.0	COG0548@1|root,COG1364@1|root,COG0548@2|Bacteria,COG1364@2|Bacteria,1MU0T@1224|Proteobacteria,42M6S@68525|delta/epsilon subdivisions,2WJU8@28221|Deltaproteobacteria,2YV2H@29|Myxococcales	28221|Deltaproteobacteria	E	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate	-	-	2.3.1.1,2.3.1.35,2.7.2.8	ko:K00620,ko:K00930	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259,R02282,R02649	RC00002,RC00004,RC00043,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ArgJ
HKD2_k127_677393_2	1192034.CAP_4568	4.885e-68	258.0	COG0515@1|root,COG0515@2|Bacteria,1Q2R6@1224|Proteobacteria,433VB@68525|delta/epsilon subdivisions,2X3MY@28221|Deltaproteobacteria,2YWK6@29|Myxococcales	28221|Deltaproteobacteria	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HKD2_k127_677393_0	1192034.CAP_6942	4.353e-91	328.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,42MVV@68525|delta/epsilon subdivisions,2X4JB@28221|Deltaproteobacteria,2YZ4I@29|Myxococcales	28221|Deltaproteobacteria	KLT	Family membership	-	-	2.7.11.1	ko:K08884	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HKD2_k127_677393_3	1192034.CAP_4745	1.19e-16	95.0	COG4105@1|root,COG4105@2|Bacteria	2|Bacteria	S	cell envelope organization	bamD	-	-	ko:K05807,ko:K08309	-	-	-	-	ko00000,ko01000,ko01011,ko02000	1.B.33.1	GH23	-	YfiO
HKD2_k127_680516_6	1144275.COCOR_01943	0.000666	50.0	COG0810@1|root,COG0810@2|Bacteria,1R65W@1224|Proteobacteria,42XJ0@68525|delta/epsilon subdivisions,2WT3A@28221|Deltaproteobacteria,2YYW2@29|Myxococcales	28221|Deltaproteobacteria	M	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins	-	-	-	-	-	-	-	-	-	-	-	-	TonB_C
HKD2_k127_680516_1	1254432.SCE1572_22825	3.69e-68	243.0	COG0631@1|root,COG0631@2|Bacteria,1R7UF@1224|Proteobacteria,42QUA@68525|delta/epsilon subdivisions,2WMWM@28221|Deltaproteobacteria,2YU7P@29|Myxococcales	28221|Deltaproteobacteria	T	Protein serine threonine phosphatase	-	-	3.1.3.16	ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C_2
HKD2_k127_680516_0	1297742.A176_03861	5.504e-101	334.0	COG0639@1|root,COG0639@2|Bacteria,1RD8M@1224|Proteobacteria,42RQP@68525|delta/epsilon subdivisions,2WNQ7@28221|Deltaproteobacteria,2YVU0@29|Myxococcales	28221|Deltaproteobacteria	T	Diadenosine tetraphosphatase and related serine threonine protein phosphatases	-	-	3.1.3.16	ko:K07313	-	-	-	-	ko00000,ko01000	-	-	-	Metallophos
HKD2_k127_680516_2	700598.Niako_5415	3.876e-45	171.0	2B80Y@1|root,3218R@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF4337)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4337
HKD2_k127_680516_4	502025.Hoch_6263	0.0001721	52.0	COG0526@1|root,COG0526@2|Bacteria,1PYQJ@1224|Proteobacteria,435HK@68525|delta/epsilon subdivisions,2WZV8@28221|Deltaproteobacteria,2Z2TQ@29|Myxococcales	28221|Deltaproteobacteria	CO	COG0526, thiol-disulfide isomerase and thioredoxins	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_680516_3	929712.KI912613_gene3646	4.499e-24	104.0	COG5552@1|root,COG5552@2|Bacteria,2IQKN@201174|Actinobacteria,4CT9K@84995|Rubrobacteria	84995|Rubrobacteria	S	Uncharacterized conserved protein (DUF2277)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2277
HKD2_k127_6808306_2	1254432.SCE1572_42585	1.85e-35	137.0	COG0192@1|root,COG0192@2|Bacteria,1MUFQ@1224|Proteobacteria,42MFM@68525|delta/epsilon subdivisions,2WIQ3@28221|Deltaproteobacteria,2YUBT@29|Myxococcales	28221|Deltaproteobacteria	H	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme	metK	GO:0003674,GO:0003824,GO:0004478,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016740,GO:0016765,GO:0044424,GO:0044444,GO:0044464	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
HKD2_k127_6808306_0	1242864.D187_001577	6.049e-104	354.0	COG3420@1|root,COG3420@2|Bacteria,1R5QH@1224|Proteobacteria	1224|Proteobacteria	P	lipolytic protein G-D-S-L family	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix
HKD2_k127_6808306_1	234267.Acid_3842	7.904e-89	316.0	COG1858@1|root,COG1858@2|Bacteria,3Y6XX@57723|Acidobacteria	57723|Acidobacteria	C	cytochrome C peroxidase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6810853_0	439235.Dalk_1971	1.969e-143	478.0	COG1012@1|root,COG1012@2|Bacteria,1MVGW@1224|Proteobacteria,42N65@68525|delta/epsilon subdivisions,2WJ98@28221|Deltaproteobacteria,2MIY4@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Aldehyde dehydrogenase family	-	-	1.2.1.3,1.2.1.68	ko:K00128,ko:K00154	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
HKD2_k127_6810853_1	1254432.SCE1572_20810	5.13e-55	201.0	COG0432@1|root,COG0432@2|Bacteria,1RH13@1224|Proteobacteria,42TMP@68525|delta/epsilon subdivisions,2WR9C@28221|Deltaproteobacteria,2YV89@29|Myxococcales	28221|Deltaproteobacteria	S	Uncharacterised protein family UPF0047	-	-	-	-	-	-	-	-	-	-	-	-	UPF0047
HKD2_k127_6810853_2	330214.NIDE4382	2.262e-29	120.0	COG0400@1|root,COG0400@2|Bacteria,3J1DU@40117|Nitrospirae	40117|Nitrospirae	S	Alpha/beta hydrolase family	-	-	-	ko:K06999	-	-	-	-	ko00000	-	-	-	Abhydrolase_2
HKD2_k127_6810930_0	404589.Anae109_3101	2.496e-144	472.0	COG0531@1|root,COG0531@2|Bacteria,1R829@1224|Proteobacteria,42MS5@68525|delta/epsilon subdivisions,2WINQ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Amino acid permease	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
HKD2_k127_6810930_1	1254432.SCE1572_10000	6.925e-108	361.0	COG0508@1|root,COG0508@2|Bacteria,1MU7K@1224|Proteobacteria,42MYB@68525|delta/epsilon subdivisions,2WIUY@28221|Deltaproteobacteria,2YU5E@29|Myxococcales	28221|Deltaproteobacteria	C	acetyltransferase component of pyruvate dehydrogenase complex	pdhC	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
HKD2_k127_6816116_8	1234364.AMSF01000015_gene3141	9.793e-06	48.0	COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,1T1FT@1236|Gammaproteobacteria,1X4UK@135614|Xanthomonadales	135614|Xanthomonadales	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HKD2_k127_6816116_0	1254432.SCE1572_42140	8.616e-124	410.0	COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,42MAR@68525|delta/epsilon subdivisions,2WJEU@28221|Deltaproteobacteria,2YWC8@29|Myxococcales	28221|Deltaproteobacteria	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HKD2_k127_6816116_9	1116232.AHBF01000055_gene270	0.0001256	53.0	COG5640@1|root,COG5640@2|Bacteria,2IEHT@201174|Actinobacteria	201174|Actinobacteria	O	Trypsin-like serine protease	-	-	-	-	-	-	-	-	-	-	-	-	Trypsin,VCBS
HKD2_k127_6816116_3	903818.KI912268_gene1595	1.403e-76	269.0	COG0009@1|root,COG0009@2|Bacteria,3Y3VW@57723|Acidobacteria	57723|Acidobacteria	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine	-	-	2.7.7.87	ko:K07566	-	-	R10463	RC00745	ko00000,ko01000,ko03009,ko03016	-	-	-	SUA5,Sua5_yciO_yrdC
HKD2_k127_6816116_2	1192034.CAP_0943	1.382e-78	269.0	COG1028@1|root,COG1028@2|Bacteria,1MUS7@1224|Proteobacteria,43AR8@68525|delta/epsilon subdivisions,2X658@28221|Deltaproteobacteria,2Z39A@29|Myxococcales	28221|Deltaproteobacteria	IQ	NAD dependent epimerase/dehydratase family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short,adh_short_C2
HKD2_k127_6816116_6	1254432.SCE1572_12195	6.594e-33	131.0	COG0251@1|root,COG0251@2|Bacteria,1RHSP@1224|Proteobacteria,434U0@68525|delta/epsilon subdivisions,2WZ4Y@28221|Deltaproteobacteria,2Z1C7@29|Myxococcales	28221|Deltaproteobacteria	J	Endoribonuclease L-PSP	-	-	-	-	-	-	-	-	-	-	-	-	Ribonuc_L-PSP
HKD2_k127_6816116_5	448385.sce1999	1.3e-33	140.0	COG1846@1|root,COG1846@2|Bacteria,1MZE9@1224|Proteobacteria,43AC7@68525|delta/epsilon subdivisions,2X5S3@28221|Deltaproteobacteria,2Z375@29|Myxococcales	28221|Deltaproteobacteria	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	MarR
HKD2_k127_6816116_1	1254432.SCE1572_12185	4.54e-105	353.0	COG1024@1|root,COG1024@2|Bacteria,1MXHV@1224|Proteobacteria,42QU2@68525|delta/epsilon subdivisions,2WMSF@28221|Deltaproteobacteria,2YYYW@29|Myxococcales	28221|Deltaproteobacteria	I	enoyl-CoA hydratase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
HKD2_k127_6816116_4	1254432.SCE1572_12180	1.426e-68	252.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,42MK5@68525|delta/epsilon subdivisions,2WJ3Z@28221|Deltaproteobacteria,2YZPZ@29|Myxococcales	28221|Deltaproteobacteria	C	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HKD2_k127_6816245_1	448385.sce3697	6.046e-127	409.0	COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,42NI4@68525|delta/epsilon subdivisions,2WKRT@28221|Deltaproteobacteria,2YY7F@29|Myxococcales	28221|Deltaproteobacteria	Q	ABC transporter, ATP-binding protein	-	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
HKD2_k127_6816245_2	1254432.SCE1572_22275	8.931e-108	359.0	COG1463@1|root,COG1463@2|Bacteria,1QTED@1224|Proteobacteria,437WX@68525|delta/epsilon subdivisions,2WWP6@28221|Deltaproteobacteria,2YVFU@29|Myxococcales	28221|Deltaproteobacteria	Q	MlaD protein	-	-	-	ko:K02067	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaD
HKD2_k127_6816245_9	1278073.MYSTI_06184	3.473e-23	100.0	COG4770@1|root,COG4770@2|Bacteria,1NJ80@1224|Proteobacteria,42WV4@68525|delta/epsilon subdivisions,2WT3X@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	Acetyl propionyl-CoA carboxylase alpha subunit	-	-	-	ko:K02160	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742	RC00040,RC00367	ko00000,ko00001,ko00002	-	-	-	Biotin_lipoyl
HKD2_k127_6816245_8	1192034.CAP_7072	6.271e-39	155.0	29Z4I@1|root,30M26@2|Bacteria,1QAWT@1224|Proteobacteria,435CA@68525|delta/epsilon subdivisions,2WZPW@28221|Deltaproteobacteria,2Z2HH@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6816245_7	1192034.CAP_7073	3.339e-57	209.0	COG0284@1|root,COG0284@2|Bacteria,1MW2C@1224|Proteobacteria,42N5N@68525|delta/epsilon subdivisions,2WMJ5@28221|Deltaproteobacteria,2YV59@29|Myxococcales	28221|Deltaproteobacteria	F	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)	pyrF	GO:0003674,GO:0003824,GO:0004590,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006207,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019856,GO:0034641,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.1.23	ko:K01591	ko00240,ko01100,map00240,map01100	M00051	R00965	RC00409	ko00000,ko00001,ko00002,ko01000	-	-	-	OMPdecase
HKD2_k127_6816245_6	448385.sce3702	1.055e-71	251.0	COG0566@1|root,COG0566@2|Bacteria,1MWCM@1224|Proteobacteria,42MZF@68525|delta/epsilon subdivisions,2WNND@28221|Deltaproteobacteria,2Z2YW@29|Myxococcales	28221|Deltaproteobacteria	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family	rlmB	-	2.1.1.185	ko:K03218	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SpoU_methylase,SpoU_sub_bind
HKD2_k127_6816245_10	521096.Tpau_1590	1.11e-12	76.0	COG1309@1|root,COG1309@2|Bacteria,2I8NQ@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	amtR	-	-	-	-	-	-	-	-	-	-	-	TetR_N
HKD2_k127_6816245_3	1254432.SCE1572_22560	1.038e-99	341.0	COG2214@1|root,COG2214@2|Bacteria	2|Bacteria	O	Heat shock protein DnaJ domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF4388,DnaJ
HKD2_k127_6816245_4	397278.JOJN01000003_gene1813	1.157e-84	304.0	COG0714@1|root,COG0714@2|Bacteria,2GMM2@201174|Actinobacteria,4DT7P@85009|Propionibacteriales	201174|Actinobacteria	S	AAA ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA,AAA_5
HKD2_k127_6816245_5	402777.KB235903_gene1209	2.662e-84	312.0	COG2114@1|root,COG5000@1|root,COG2114@2|Bacteria,COG5000@2|Bacteria,1FZXP@1117|Cyanobacteria,1H71W@1150|Oscillatoriales	1117|Cyanobacteria	T	Belongs to the adenylyl cyclase class-4 guanylyl cyclase family	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,HAMP,HNOBA,dCache_1
HKD2_k127_6816245_0	448385.sce3750	6.532e-130	428.0	COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,42MGP@68525|delta/epsilon subdivisions,2WIZ2@28221|Deltaproteobacteria,2YU4G@29|Myxococcales	28221|Deltaproteobacteria	L	DNA polymerase	dnaE	-	2.7.7.7	ko:K02337,ko:K14162	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
HKD2_k127_6834575_0	448385.sce7807	0.0	1394.0	COG0642@1|root,COG0840@1|root,COG1511@1|root,COG2770@1|root,COG0840@2|Bacteria,COG1511@2|Bacteria,COG2205@2|Bacteria,COG2770@2|Bacteria,1NRP8@1224|Proteobacteria,42MW4@68525|delta/epsilon subdivisions,2WKWD@28221|Deltaproteobacteria,2Z3GS@29|Myxococcales	28221|Deltaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	4HB_MCP_1,GAF_2,HAMP,HATPase_c,HisKA,Response_reg
HKD2_k127_6834575_12	1267535.KB906767_gene371	4.418e-43	166.0	COG2905@1|root,COG2905@2|Bacteria,3Y5NG@57723|Acidobacteria,2JN0N@204432|Acidobacteriia	204432|Acidobacteriia	T	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
HKD2_k127_6834575_8	439235.Dalk_5164	9.781e-64	225.0	2FCUT@1|root,344XR@2|Bacteria,1P20K@1224|Proteobacteria,4320S@68525|delta/epsilon subdivisions,2WWIJ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6834575_5	215803.DB30_4902	5.15e-75	278.0	28IH4@1|root,2Z8IE@2|Bacteria,1N4IS@1224|Proteobacteria,433ZD@68525|delta/epsilon subdivisions,2X47C@28221|Deltaproteobacteria,2YYEK@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6834575_11	640511.BC1002_7112	2.626e-45	181.0	COG0644@1|root,COG0644@2|Bacteria,1PGHR@1224|Proteobacteria,2VT2Q@28216|Betaproteobacteria,1KAQP@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Lycopene cyclase protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6834575_6	653733.Selin_2170	1.923e-67	256.0	28IHR@1|root,2Z8IY@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6834575_3	1278073.MYSTI_01148	4.164e-97	324.0	COG1024@1|root,COG1024@2|Bacteria,1R3Q4@1224|Proteobacteria	1224|Proteobacteria	I	Enoyl-CoA hydratase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
HKD2_k127_6834575_1	1254432.SCE1572_44245	7.153e-231	728.0	COG1132@1|root,COG1132@2|Bacteria,1MXC2@1224|Proteobacteria,42PQK@68525|delta/epsilon subdivisions,2WJCT@28221|Deltaproteobacteria,2YUHK@29|Myxococcales	28221|Deltaproteobacteria	P	ABC transporter	-	-	-	ko:K06147,ko:K06148	-	-	-	-	ko00000,ko02000	3.A.1,3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
HKD2_k127_6834575_2	1254432.SCE1572_50055	1.533e-144	475.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2Z2X4@29|Myxococcales	28221|Deltaproteobacteria	T	Bacterial regulatory protein, Fis family	-	-	-	ko:K02481,ko:K07713	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD2_k127_6834575_13	1242864.D187_008946	6.741e-39	160.0	COG0642@1|root,COG2205@2|Bacteria,1MXH7@1224|Proteobacteria,43AYG@68525|delta/epsilon subdivisions	1224|Proteobacteria	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	2.7.13.3	ko:K07636	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
HKD2_k127_6834575_18	1144275.COCOR_05819	2.401e-13	83.0	COG2385@1|root,COG3170@1|root,COG2385@2|Bacteria,COG3170@2|Bacteria,1R3TU@1224|Proteobacteria	1224|Proteobacteria	NU	Belongs to the peptidase M12A family	nas	-	3.4.24.21	ko:K08076	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Astacin
HKD2_k127_6834575_7	1121946.AUAX01000010_gene3776	5.33e-66	246.0	COG0791@1|root,COG3757@1|root,COG0791@2|Bacteria,COG3757@2|Bacteria	2|Bacteria	M	lysozyme activity	-	-	3.4.17.14	ko:K07260	ko00550,ko01100,ko01502,ko02020,map00550,map01100,map01502,map02020	M00651	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504	-	-	-	Amidase_2,DUF1906,Glyco_hydro_92
HKD2_k127_6834575_16	290397.Adeh_1746	4.812e-15	83.0	2AGMF@1|root,316UN@2|Bacteria,1PY1C@1224|Proteobacteria,43E04@68525|delta/epsilon subdivisions,2WZBK@28221|Deltaproteobacteria,2Z1SE@29|Myxococcales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF1109)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1109
HKD2_k127_6834575_20	33876.JNXY01000027_gene3657	1.199e-10	73.0	COG3852@1|root,COG4191@1|root,COG3852@2|Bacteria,COG4191@2|Bacteria,2IF7B@201174|Actinobacteria,4DH3U@85008|Micromonosporales	201174|Actinobacteria	T	PAS fold	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3,PAS_4,Response_reg
HKD2_k127_6834575_4	1192034.CAP_4649	1.847e-94	328.0	COG2931@1|root,COG2931@2|Bacteria,1PG5F@1224|Proteobacteria,43F2Q@68525|delta/epsilon subdivisions,2X35A@28221|Deltaproteobacteria,2YY8H@29|Myxococcales	28221|Deltaproteobacteria	Q	Parallel beta-helix repeats	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6834575_14	309801.trd_A0193	4.781e-35	143.0	COG4314@1|root,COG4314@2|Bacteria,2G8NV@200795|Chloroflexi,27Z7G@189775|Thermomicrobia	189775|Thermomicrobia	C	lipoprotein involved in nitrous oxide reduction	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6834575_17	768671.ThimaDRAFT_0916	2.244e-13	70.0	COG4263@1|root,COG4263@2|Bacteria,1MVIH@1224|Proteobacteria,1RQSW@1236|Gammaproteobacteria,1WZYX@135613|Chromatiales	135613|Chromatiales	C	Cytochrome c oxidase subunit	nosZ	-	1.7.2.4	ko:K00376	ko00910,ko01120,map00910,map01120	M00529	R02804	RC02861	ko00000,ko00001,ko00002,ko01000	-	-	-	COX2,Cupredoxin_1
HKD2_k127_6837201_2	882082.SaccyDRAFT_4767	4.641e-71	252.0	COG0657@1|root,COG0657@2|Bacteria,2GKX2@201174|Actinobacteria,4DYGY@85010|Pseudonocardiales	201174|Actinobacteria	I	Alpha beta hydrolase	-	-	-	ko:K01066	-	-	-	-	ko00000,ko01000	-	-	-	Abhydrolase_3
HKD2_k127_6837201_0	1254432.SCE1572_49820	4.249e-222	703.0	COG0578@1|root,COG0578@2|Bacteria,1MUMY@1224|Proteobacteria,42M8D@68525|delta/epsilon subdivisions,2WJ6E@28221|Deltaproteobacteria,2YWFY@29|Myxococcales	28221|Deltaproteobacteria	C	C-terminal domain of alpha-glycerophosphate oxidase	glpA	-	1.1.5.3	ko:K00111	ko00564,ko01110,map00564,map01110	-	R00848	RC00029	ko00000,ko00001,ko01000	-	-	-	DAO,DAO_C,Fer2_BFD
HKD2_k127_6837201_1	1242864.D187_001837	3.803e-84	299.0	COG0784@1|root,COG4191@1|root,COG0784@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42Q3F@68525|delta/epsilon subdivisions,2WM2F@28221|Deltaproteobacteria,2YUEQ@29|Myxococcales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_8,PAS_9,Response_reg
HKD2_k127_6837201_4	1254432.SCE1572_49825	3.248e-20	90.0	COG0463@1|root,COG0463@2|Bacteria,1NKDW@1224|Proteobacteria,42XGP@68525|delta/epsilon subdivisions,2WTBI@28221|Deltaproteobacteria,2YUTR@29|Myxococcales	28221|Deltaproteobacteria	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HKD2_k127_6844048_1	448385.sce8545	2.163e-83	289.0	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,42MMK@68525|delta/epsilon subdivisions,2WJC1@28221|Deltaproteobacteria,2YU05@29|Myxococcales	28221|Deltaproteobacteria	S	ABC transporter	uup	-	-	ko:K15738	-	-	-	-	ko00000,ko02000	3.A.1.120.6	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
HKD2_k127_6844048_2	661478.OP10G_0570	5.329e-74	253.0	COG0431@1|root,COG0431@2|Bacteria	2|Bacteria	S	FMN reductase (NADPH) activity	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
HKD2_k127_6844048_3	1192034.CAP_7191	6.661e-57	217.0	2ANKP@1|root,31DJW@2|Bacteria,1QAVS@1224|Proteobacteria,435BV@68525|delta/epsilon subdivisions,2WZPD@28221|Deltaproteobacteria,2Z2GM@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6844048_0	1192034.CAP_7190	2.704e-122	409.0	COG0515@1|root,COG0515@2|Bacteria,1Q35Q@1224|Proteobacteria,438W9@68525|delta/epsilon subdivisions,2X41T@28221|Deltaproteobacteria,2YXZI@29|Myxococcales	28221|Deltaproteobacteria	KLT	Protein kinase domain	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
HKD2_k127_687209_0	1206732.BAGD01000053_gene1866	2.063e-50	198.0	COG0204@1|root,COG0204@2|Bacteria,2GNBB@201174|Actinobacteria,4FZHY@85025|Nocardiaceae	201174|Actinobacteria	I	Diacylglycerol acyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acyltransferase
HKD2_k127_687209_1	1122604.JONR01000015_gene156	2.708e-22	111.0	COG1020@1|root,COG1020@2|Bacteria,1N7HY@1224|Proteobacteria,1S1HS@1236|Gammaproteobacteria,1X48P@135614|Xanthomonadales	135614|Xanthomonadales	Q	Protein of unknown function (DUF1298)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1298,WES_acyltransf
HKD2_k127_6878464_5	63737.Npun_F5503	1.677e-74	267.0	COG1004@1|root,COG1004@2|Bacteria,1G1GI@1117|Cyanobacteria,1HINT@1161|Nostocales	2|Bacteria	C	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	algD	-	1.1.1.132,1.1.1.22	ko:K00012,ko:K00066	ko00040,ko00051,ko00053,ko00520,ko01100,ko02020,map00040,map00051,map00053,map00520,map01100,map02020	M00014,M00129,M00361,M00362	R00286,R00880	RC00291	ko00000,ko00001,ko00002,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
HKD2_k127_6878464_10	1430440.MGMSRv2_3469	1.588e-14	87.0	2E3ZS@1|root,32YWP@2|Bacteria,1NAZV@1224|Proteobacteria,2UGW3@28211|Alphaproteobacteria,2JXCF@204441|Rhodospirillales	204441|Rhodospirillales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6878464_0	1191523.MROS_1641	7.341e-230	733.0	COG2192@1|root,COG2192@2|Bacteria	2|Bacteria	O	nodulation	-	-	-	ko:K00612	-	-	-	-	ko00000,ko01000	-	-	-	Carbam_trans_C,Carbam_trans_N
HKD2_k127_6878464_9	344747.PM8797T_18926	3.619e-27	129.0	COG2755@1|root,COG2755@2|Bacteria	2|Bacteria	E	lipolytic protein G-D-S-L family	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6878464_11	204669.Acid345_1583	1.277e-09	71.0	COG1807@1|root,COG1807@2|Bacteria,3Y2UV@57723|Acidobacteria,2JIS6@204432|Acidobacteriia	204432|Acidobacteriia	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HKD2_k127_6878464_3	1267534.KB906755_gene4091	1.131e-82	282.0	COG1216@1|root,COG1216@2|Bacteria	2|Bacteria	V	Glycosyl transferase, family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HKD2_k127_6878464_2	59921.EU92_0263	1.471e-110	366.0	COG0451@1|root,COG0451@2|Bacteria,1G44E@1117|Cyanobacteria	1117|Cyanobacteria	M	PFAM NAD-dependent epimerase dehydratase	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
HKD2_k127_6878464_7	13035.Dacsa_3620	1.839e-34	153.0	28J0X@1|root,2Z8Y1@2|Bacteria,1G74Y@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6878464_12	258533.BN977_05148	8.659e-09	66.0	COG0500@1|root,COG0500@2|Bacteria,2GX4K@201174|Actinobacteria,23F4V@1762|Mycobacteriaceae	201174|Actinobacteria	Q	Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
HKD2_k127_6878464_14	596152.DesU5LDRAFT_3345	4.95e-07	62.0	COG2755@1|root,COG2755@2|Bacteria,1NHW6@1224|Proteobacteria,42XAM@68525|delta/epsilon subdivisions,2WSXZ@28221|Deltaproteobacteria,2MDU0@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	GDSL-like Lipase/Acylhydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
HKD2_k127_6878464_13	448385.sce8733	3.899e-08	57.0	29XGE@1|root,30J6W@2|Bacteria,1R0E6@1224|Proteobacteria,43CWN@68525|delta/epsilon subdivisions,2WUSC@28221|Deltaproteobacteria,2Z1N5@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6878464_4	1267533.KB906734_gene3952	5.442e-77	269.0	2DNAS@1|root,32WH6@2|Bacteria,3Y5UC@57723|Acidobacteria,2JKNS@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6878464_1	234267.Acid_3960	1.425e-142	463.0	COG0111@1|root,COG0111@2|Bacteria,3Y7TQ@57723|Acidobacteria	57723|Acidobacteria	EH	D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding	-	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
HKD2_k127_6878464_6	1192034.CAP_0612	2.976e-69	265.0	COG0515@1|root,COG0515@2|Bacteria	1192034.CAP_0612|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6878464_8	1192034.CAP_3157	5.678e-32	145.0	COG4105@1|root,COG4105@2|Bacteria	2|Bacteria	S	cell envelope organization	bamD	-	-	ko:K05807,ko:K08309	-	-	-	-	ko00000,ko01000,ko01011,ko02000	1.B.33.1	GH23	-	YfiO
HKD2_k127_6899575_0	330214.NIDE0726	4.418e-148	497.0	COG0841@1|root,COG0841@2|Bacteria,3J0ZG@40117|Nitrospirae	40117|Nitrospirae	V	AcrB/AcrD/AcrF family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
HKD2_k127_6899575_6	671143.DAMO_1544	1.034e-34	154.0	COG4191@1|root,COG4191@2|Bacteria,2NPGF@2323|unclassified Bacteria	2|Bacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
HKD2_k127_6899575_1	215803.DB30_1154	1.162e-111	382.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WJKZ@28221|Deltaproteobacteria,2YXVA@29|Myxococcales	28221|Deltaproteobacteria	T	Bacterial regulatory protein, Fis family	-	-	-	ko:K07713	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD2_k127_6899575_13	509190.Cseg_0495	7.142e-09	68.0	COG3712@1|root,COG3712@2|Bacteria,1NYVF@1224|Proteobacteria,2UT27@28211|Alphaproteobacteria,2KIY9@204458|Caulobacterales	204458|Caulobacterales	PT	FecR protein	-	-	-	-	-	-	-	-	-	-	-	-	FecR
HKD2_k127_6899575_7	1254432.SCE1572_50145	9.417e-34	139.0	COG1595@1|root,COG1595@2|Bacteria,1N4RS@1224|Proteobacteria,43E0K@68525|delta/epsilon subdivisions,2WZCJ@28221|Deltaproteobacteria,2Z1UN@29|Myxococcales	28221|Deltaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD2_k127_6899575_5	1278073.MYSTI_07438	3.296e-42	162.0	COG0526@1|root,COG0526@2|Bacteria,1QVCY@1224|Proteobacteria,43BX7@68525|delta/epsilon subdivisions,2X780@28221|Deltaproteobacteria,2Z3DU@29|Myxococcales	28221|Deltaproteobacteria	O	Thioredoxin	trx	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
HKD2_k127_6899575_11	999549.KI421513_gene2232	2.199e-16	88.0	2EGD6@1|root,33A4Z@2|Bacteria,1N733@1224|Proteobacteria,2UG8Q@28211|Alphaproteobacteria,282FB@191028|Leisingera	28211|Alphaproteobacteria	S	Protein of unknown function (DUF2892)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2892
HKD2_k127_6899575_8	1192034.CAP_6237	1.271e-25	115.0	COG5164@1|root,COG5164@2|Bacteria,1R0C5@1224|Proteobacteria,43CUH@68525|delta/epsilon subdivisions,2X826@28221|Deltaproteobacteria,2Z24H@29|Myxococcales	28221|Deltaproteobacteria	K	regulation of DNA-templated transcription, elongation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6899575_3	290397.Adeh_0437	8.504e-60	221.0	COG2059@1|root,COG2059@2|Bacteria,1RB6A@1224|Proteobacteria,43B62@68525|delta/epsilon subdivisions,2X6JK@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	Chromate transporter	-	-	-	ko:K07240	-	-	-	-	ko00000,ko02000	2.A.51.1	-	-	Chromate_transp
HKD2_k127_6899575_10	118163.Ple7327_2598	1.794e-16	83.0	COG2149@1|root,COG2149@2|Bacteria,1G61R@1117|Cyanobacteria,3VJZG@52604|Pleurocapsales	1117|Cyanobacteria	S	membrane	-	-	-	ko:K00389	-	-	-	-	ko00000	-	-	-	DUF202
HKD2_k127_6899575_9	1192034.CAP_5403	4.342e-17	87.0	COG0589@1|root,COG0589@2|Bacteria	2|Bacteria	T	AMP binding	uspA4	GO:0008150,GO:0040007	-	-	-	-	-	-	-	-	-	-	Usp
HKD2_k127_6899575_12	1348663.KCH_11980	1.289e-12	73.0	2B7Y0@1|root,32153@2|Bacteria,2I267@201174|Actinobacteria,2M63G@2063|Kitasatospora	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6899575_4	290397.Adeh_0794	1.348e-55	203.0	COG1595@1|root,COG1595@2|Bacteria,1MVPD@1224|Proteobacteria,43AKN@68525|delta/epsilon subdivisions,2X60M@28221|Deltaproteobacteria,2Z1JH@29|Myxococcales	28221|Deltaproteobacteria	K	Putative zinc-finger	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2,zf-HC2
HKD2_k127_6899575_2	857087.Metme_3278	1.052e-108	362.0	COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,1RQ2G@1236|Gammaproteobacteria,1XDIS@135618|Methylococcales	135618|Methylococcales	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	-	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
HKD2_k127_6902523_0	330214.NIDE0726	2.463e-258	823.0	COG0841@1|root,COG0841@2|Bacteria,3J0ZG@40117|Nitrospirae	40117|Nitrospirae	V	AcrB/AcrD/AcrF family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
HKD2_k127_6910266_7	373903.Hore_03690	1.087e-18	93.0	COG0798@1|root,COG0798@2|Bacteria,1TRMD@1239|Firmicutes,24958@186801|Clostridia,3WC7S@53433|Halanaerobiales	186801|Clostridia	P	PFAM Sodium Bile acid symporter family	-	-	-	ko:K03325	-	-	-	-	ko00000,ko02000	2.A.59	-	-	SBF
HKD2_k127_6910266_3	1049564.TevJSym_ak00210	8.571e-35	137.0	COG1765@1|root,COG1765@2|Bacteria,1N1RR@1224|Proteobacteria,1S3KI@1236|Gammaproteobacteria,1J71R@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	O	OsmC-like protein	-	-	-	-	-	-	-	-	-	-	-	-	OsmC
HKD2_k127_6910266_2	240015.ACP_1412	4.338e-40	168.0	COG0500@1|root,COG2226@2|Bacteria,3Y9BH@57723|Acidobacteria,2JP5Y@204432|Acidobacteriia	204432|Acidobacteriia	Q	Met-10+ like-protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6910266_4	479431.Namu_0358	1.323e-32	144.0	COG0526@1|root,COG0526@2|Bacteria,2IKP1@201174|Actinobacteria,4EXGH@85013|Frankiales	201174|Actinobacteria	O	Belongs to the thioredoxin family	-	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
HKD2_k127_6910266_5	290397.Adeh_3932	3.995e-30	128.0	COG3439@1|root,COG3439@2|Bacteria,1RH9Z@1224|Proteobacteria,42VVC@68525|delta/epsilon subdivisions,2WRH9@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Domain of unknown function DUF302	-	-	-	-	-	-	-	-	-	-	-	-	DUF302
HKD2_k127_6910266_1	1144275.COCOR_00929	2.484e-50	196.0	COG0642@1|root,COG3437@1|root,COG2205@2|Bacteria,COG3437@2|Bacteria,1QX9H@1224|Proteobacteria,43E4H@68525|delta/epsilon subdivisions,2X7DA@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_4
HKD2_k127_6910266_0	1192034.CAP_5418	2.998e-117	417.0	COG0515@1|root,COG0515@2|Bacteria	1192034.CAP_5418|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6916557_4	1123354.AUDR01000015_gene349	3.936e-05	56.0	COG1488@1|root,COG1488@2|Bacteria,1PNWY@1224|Proteobacteria,2W9DN@28216|Betaproteobacteria,1KS4Z@119069|Hydrogenophilales	119069|Hydrogenophilales	H	Nicotinate phosphoribosyltransferase (NAPRTase) family	-	-	-	-	-	-	-	-	-	-	-	-	NAPRTase
HKD2_k127_6916557_2	497964.CfE428DRAFT_1977	2.165e-58	211.0	COG1051@1|root,COG1051@2|Bacteria,46SHC@74201|Verrucomicrobia	74201|Verrucomicrobia	F	NUDIX domain	-	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX
HKD2_k127_6916557_1	1254432.SCE1572_48410	1.762e-108	359.0	COG0003@1|root,COG0003@2|Bacteria,1NA7C@1224|Proteobacteria,42V2J@68525|delta/epsilon subdivisions,2WS25@28221|Deltaproteobacteria,2YUZS@29|Myxococcales	28221|Deltaproteobacteria	P	Anion-transporting ATPase	-	-	3.6.3.16	ko:K01551	-	-	-	-	ko00000,ko01000,ko02000	3.A.19.1,3.A.21.1,3.A.4.1	-	-	ArsA_ATPase
HKD2_k127_6916557_0	1232410.KI421428_gene1071	1.037e-114	389.0	COG0595@1|root,COG0595@2|Bacteria,1MUGV@1224|Proteobacteria,42M65@68525|delta/epsilon subdivisions,2WIQ9@28221|Deltaproteobacteria,43S6F@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Zn-dependent metallo-hydrolase RNA specificity domain	rnj	-	-	ko:K12574	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	Lactamase_B,Lactamase_B_2,RMMBL
HKD2_k127_6916557_3	448385.sce0376	6.413e-25	121.0	COG5607@1|root,COG5607@2|Bacteria,1NGVB@1224|Proteobacteria	1224|Proteobacteria	S	PFAM CHAD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CHAD
HKD2_k127_6950154_5	555793.WSK_1713	4.801e-13	72.0	COG2268@1|root,COG2268@2|Bacteria,1P50K@1224|Proteobacteria,2TTVY@28211|Alphaproteobacteria,2K0BQ@204457|Sphingomonadales	204457|Sphingomonadales	S	Flotillin	-	-	-	-	-	-	-	-	-	-	-	-	Band_7,Flot
HKD2_k127_6950154_6	316274.Haur_1412	3.505e-09	66.0	COG1585@1|root,COG1585@2|Bacteria	2|Bacteria	OU	cellular response to DNA damage stimulus	yuaF	GO:0005575,GO:0005623,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0016020,GO:0033554,GO:0044464,GO:0050896,GO:0051716,GO:0071944	-	-	-	-	-	-	-	-	-	-	DUF1449,NfeD
HKD2_k127_6950154_4	1380354.JIAN01000006_gene622	2.603e-21	102.0	COG2227@1|root,COG2227@2|Bacteria,2IJEF@201174|Actinobacteria	201174|Actinobacteria	H	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23
HKD2_k127_6950154_7	797303.Natpe_0929	3.881e-07	62.0	arCOG03058@1|root,arCOG03058@2157|Archaea,2XWZ5@28890|Euryarchaeota,23V65@183963|Halobacteria	183963|Halobacteria	I	COG0671 Membrane-associated phospholipid phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	PAP2
HKD2_k127_6950154_9	58344.JOEL01000051_gene2823	1.518e-06	56.0	COG1396@1|root,COG1396@2|Bacteria,2GPWH@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2,HTH_3,HTH_31
HKD2_k127_6950154_10	1120792.JAFV01000001_gene1623	1.613e-05	51.0	COG0745@1|root,COG0745@2|Bacteria,1MU67@1224|Proteobacteria,2TRTZ@28211|Alphaproteobacteria,36XS9@31993|Methylocystaceae	28211|Alphaproteobacteria	T	Transcriptional regulatory protein, C terminal	ragA	GO:0000160,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005515,GO:0006355,GO:0007154,GO:0007165,GO:0008150,GO:0009889,GO:0009893,GO:0009987,GO:0010035,GO:0010038,GO:0010468,GO:0010556,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0023052,GO:0031323,GO:0031326,GO:0035556,GO:0042221,GO:0042802,GO:0046688,GO:0048518,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141	-	ko:K02483	-	-	-	-	ko00000,ko02022	-	-	-	Response_reg,Trans_reg_C
HKD2_k127_6950154_8	420247.Msm_0446	4.862e-07	60.0	COG0372@1|root,arCOG04237@2157|Archaea,2XT24@28890|Euryarchaeota,23PEN@183925|Methanobacteria	183925|Methanobacteria	C	PFAM Citrate	-	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
HKD2_k127_6950154_3	1242864.D187_006147	3.145e-30	137.0	COG0642@1|root,COG0745@1|root,COG4251@1|root,COG0745@2|Bacteria,COG2205@2|Bacteria,COG4251@2|Bacteria,1NRP8@1224|Proteobacteria,43C1T@68525|delta/epsilon subdivisions,2X7CE@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg
HKD2_k127_6950154_0	398767.Glov_1114	4.646e-128	432.0	COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,42M1X@68525|delta/epsilon subdivisions,2WJA2@28221|Deltaproteobacteria,43SU0@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	thiamine pyrophosphate protein TPP binding domain protein	-	-	1.2.5.1,2.2.1.6	ko:K00156,ko:K01652	ko00290,ko00620,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00620,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R03145,R04672,R04673,R08648	RC00027,RC00106,RC00860,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
HKD2_k127_6950154_2	1215092.PA6_007_00420	6.141e-40	164.0	COG2836@1|root,COG2836@2|Bacteria,1RIGJ@1224|Proteobacteria,1S5V1@1236|Gammaproteobacteria,1YDRC@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	S	Cytochrome C biogenesis protein transmembrane region	braZ	-	-	ko:K09792	-	-	-	-	ko00000	-	-	-	DsbD_2
HKD2_k127_6950154_1	1278073.MYSTI_06113	1.182e-127	420.0	COG0348@1|root,COG0348@2|Bacteria,1MVFY@1224|Proteobacteria,42M8Q@68525|delta/epsilon subdivisions,2WNZJ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	ccoG	-	-	-	-	-	-	-	-	-	-	-	Fer4_18,Fer4_5,FixG_C
HKD2_k127_6976272_3	1192034.CAP_8373	3.76e-21	96.0	COG0457@1|root,COG0457@2|Bacteria	1192034.CAP_8373|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6976272_4	502025.Hoch_6795	1.116e-16	95.0	COG5184@1|root,COG5184@2|Bacteria,1P1C6@1224|Proteobacteria,4310A@68525|delta/epsilon subdivisions,2WWWF@28221|Deltaproteobacteria,2Z029@29|Myxococcales	28221|Deltaproteobacteria	DZ	Putative metal-binding motif	-	-	-	-	-	-	-	-	-	-	-	-	Cu-binding_MopE
HKD2_k127_6976272_0	1125863.JAFN01000001_gene291	1.27e-116	393.0	COG0014@1|root,COG0014@2|Bacteria,1MUGJ@1224|Proteobacteria,42ME0@68525|delta/epsilon subdivisions,2WJB8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate	proA	GO:0003674,GO:0003824,GO:0004350,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0055114	1.2.1.41	ko:K00147	ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230	M00015	R03313	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
HKD2_k127_6976272_2	1254432.SCE1572_22165	8.692e-37	145.0	COG0799@1|root,COG0799@2|Bacteria,1MZEF@1224|Proteobacteria,42VN5@68525|delta/epsilon subdivisions,2WRGG@28221|Deltaproteobacteria,2YVQW@29|Myxococcales	28221|Deltaproteobacteria	J	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation	rsfS	-	-	ko:K09710	-	-	-	-	ko00000,ko03009	-	-	-	RsfS
HKD2_k127_6976272_1	1192034.CAP_6994	3.056e-48	178.0	COG0805@1|root,COG0805@2|Bacteria,1MVAY@1224|Proteobacteria,42MM7@68525|delta/epsilon subdivisions,2WKJW@28221|Deltaproteobacteria,2YVGX@29|Myxococcales	28221|Deltaproteobacteria	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides	tatC	-	-	ko:K03118	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	TatC
HKD2_k127_6982606_1	1242864.D187_001429	6.027e-62	232.0	COG0642@1|root,COG3829@1|root,COG2205@2|Bacteria,COG3829@2|Bacteria,1MXH7@1224|Proteobacteria,43AYG@68525|delta/epsilon subdivisions	1224|Proteobacteria	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	2.7.13.3	ko:K07636	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
HKD2_k127_6982606_2	243231.GSU2401	1.124e-22	113.0	COG2203@1|root,COG4191@1|root,COG2203@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42M1R@68525|delta/epsilon subdivisions,2WJ5T@28221|Deltaproteobacteria,43SYP@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS_3,PAS_4,Response_reg,dCache_1
HKD2_k127_6982606_0	926554.KI912640_gene1366	3.005e-71	247.0	COG1960@1|root,COG1960@2|Bacteria,1WMGQ@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_2,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HKD2_k127_6998582_0	448385.sce2668	1.024e-104	370.0	COG2203@1|root,COG3829@1|root,COG2203@2|Bacteria,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria	1224|Proteobacteria	K	PFAM sigma-54 factor interaction domain-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HTH_8,Sigma54_activat
HKD2_k127_6999370_5	448385.sce9100	2.291e-34	138.0	COG1262@1|root,COG1404@1|root,COG2931@1|root,COG1262@2|Bacteria,COG1404@2|Bacteria,COG2931@2|Bacteria,1QADC@1224|Proteobacteria,43504@68525|delta/epsilon subdivisions,2X3M0@28221|Deltaproteobacteria,2YWGK@29|Myxococcales	28221|Deltaproteobacteria	O	GON domain	-	-	-	-	-	-	-	-	-	-	-	-	GON
HKD2_k127_6999370_4	1038859.AXAU01000001_gene3168	1.599e-35	146.0	COG0463@1|root,COG0463@2|Bacteria,1QTWH@1224|Proteobacteria,2TRNC@28211|Alphaproteobacteria,3JXZY@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HKD2_k127_6999370_6	1064537.AGSO01000002_gene363	8.018e-09	62.0	COG2456@1|root,COG2456@2|Bacteria,2HHH2@201174|Actinobacteria,4FCZM@85020|Dermabacteraceae	201174|Actinobacteria	S	Uncharacterized conserved protein (DUF2304)	-	-	-	ko:K09153	-	-	-	-	ko00000	-	-	-	DUF2304
HKD2_k127_6999370_3	1541065.JRFE01000003_gene5374	3.265e-72	260.0	28H6C@1|root,2Z7IV@2|Bacteria,1G3DU@1117|Cyanobacteria,3VHK6@52604|Pleurocapsales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6999370_0	1242864.D187_005995	1.765e-158	519.0	COG2072@1|root,COG2072@2|Bacteria,1MUQH@1224|Proteobacteria,438GG@68525|delta/epsilon subdivisions,2X3RB@28221|Deltaproteobacteria,2YWX5@29|Myxococcales	28221|Deltaproteobacteria	P	Flavin-binding monooxygenase-like	-	-	-	-	-	-	-	-	-	-	-	-	FMO-like
HKD2_k127_6999370_2	479435.Kfla_5059	1.449e-79	280.0	COG3266@1|root,COG3266@2|Bacteria,2I44K@201174|Actinobacteria,4DRNT@85009|Propionibacteriales	201174|Actinobacteria	S	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6999370_1	448385.sce0815	2.844e-134	437.0	2E4Q1@1|root,32ZIN@2|Bacteria,1R6IY@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6999742_1	102129.Lepto7375DRAFT_4207	1.457e-48	196.0	COG1073@1|root,COG1073@2|Bacteria,1GBEW@1117|Cyanobacteria	1117|Cyanobacteria	S	alpha beta	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6999742_3	1380387.JADM01000004_gene2966	1.646e-26	120.0	COG1075@1|root,COG1075@2|Bacteria,1R75P@1224|Proteobacteria,1SDJJ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	acetyltransferases and hydrolases with the alpha beta hydrolase fold	-	-	3.1.1.3	ko:K01046	ko00561,ko01100,map00561,map01100	M00098	R02250,R02687	RC00020,RC00037,RC00041,RC00094	ko00000,ko00001,ko00002,ko01000	-	-	-	Abhydrolase_1,Lipase_2,PGAP1
HKD2_k127_6999742_2	1134474.O59_000004	1.543e-45	178.0	COG3757@1|root,COG3757@2|Bacteria,1N792@1224|Proteobacteria,1S6KA@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	glycoside hydrolase, family	-	-	-	ko:K07273	-	-	-	-	ko00000	-	-	-	Glyco_hydro_25
HKD2_k127_6999742_0	1192034.CAP_7183	1.392e-123	410.0	COG2303@1|root,COG2303@2|Bacteria,1PEB3@1224|Proteobacteria,42WR0@68525|delta/epsilon subdivisions,2WS23@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	GMC oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GMC_oxred_C,GMC_oxred_N
HKD2_k127_700378_1	448385.sce8140	7.298e-91	340.0	COG3119@1|root,COG3119@2|Bacteria	2|Bacteria	P	arylsulfatase activity	-	-	-	-	-	-	-	-	-	-	-	-	Cu-binding_MopE,Sulfatase
HKD2_k127_700378_0	1192034.CAP_5394	1.308e-124	429.0	COG2197@1|root,COG2199@1|root,COG2197@2|Bacteria,COG3706@2|Bacteria	2|Bacteria	T	GGDEF domain	cheY	-	3.1.1.61,3.5.1.44	ko:K03412,ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheX,HATPase_c,HDOD,HisKA,Response_reg
HKD2_k127_7004066_2	290397.Adeh_1323	8.409e-21	101.0	COG0517@1|root,COG0517@2|Bacteria,1N68U@1224|Proteobacteria,42UEN@68525|delta/epsilon subdivisions,2X9VF@28221|Deltaproteobacteria,2YVE6@29|Myxococcales	28221|Deltaproteobacteria	K	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
HKD2_k127_7004066_1	1124780.ANNU01000005_gene2536	1.064e-25	117.0	COG1723@1|root,COG1723@2|Bacteria,4NFED@976|Bacteroidetes,47V2F@768503|Cytophagia	976|Bacteroidetes	S	Uncharacterised ACR, YagE family COG1723	-	-	-	-	-	-	-	-	-	-	-	-	DUF155
HKD2_k127_7004066_0	1254432.SCE1572_42920	7.253e-39	160.0	COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,42MFT@68525|delta/epsilon subdivisions,2WIXC@28221|Deltaproteobacteria,2YWED@29|Myxococcales	28221|Deltaproteobacteria	U	Ammonium Transporter Family	amtB	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
HKD2_k127_7006676_2	1157632.AQWQ01000010_gene564	5.892e-31	128.0	2DSXA@1|root,33HT5@2|Bacteria,2HG8U@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7006676_1	1249997.JHZW01000002_gene392	2.966e-40	158.0	2BPCN@1|root,32I4P@2|Bacteria,4PE2I@976|Bacteroidetes,1IEGC@117743|Flavobacteriia,2PHUI@252356|Maribacter	976|Bacteroidetes	S	Domain of unknown function (DUF4272)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4272
HKD2_k127_7006676_0	243231.GSU0541	9.739e-106	381.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,42NAV@68525|delta/epsilon subdivisions,2WJ3W@28221|Deltaproteobacteria,43TIJ@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
HKD2_k127_7022391_0	404589.Anae109_3565	3.122e-86	292.0	COG1066@1|root,COG1066@2|Bacteria,1MUJQ@1224|Proteobacteria,42MG8@68525|delta/epsilon subdivisions,2WJWP@28221|Deltaproteobacteria,2YX7S@29|Myxococcales	28221|Deltaproteobacteria	O	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function	radA	-	-	ko:K04485	-	-	-	-	ko00000,ko03400	-	-	-	AAA_25,ATPase,ChlI,Lon_C
HKD2_k127_7022391_1	1192034.CAP_4603	1.21e-35	152.0	COG0526@1|root,COG0526@2|Bacteria,1N726@1224|Proteobacteria,42U61@68525|delta/epsilon subdivisions,2WQRF@28221|Deltaproteobacteria,2YVWK@29|Myxococcales	28221|Deltaproteobacteria	CO	Thioredoxin-like	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
HKD2_k127_7025553_0	977880.RALTA_A0713	1.902e-93	316.0	COG4262@1|root,COG4262@2|Bacteria,1RFPU@1224|Proteobacteria,2VQJ5@28216|Betaproteobacteria,1K6DM@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Spermidine synthase	-	-	2.5.1.16	ko:K00797	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	M00034,M00133	R01920,R02869,R08359	RC00021,RC00053	ko00000,ko00001,ko00002,ko01000	-	-	-	Spermine_synth
HKD2_k127_7049780_2	290397.Adeh_1271	7.327e-17	87.0	COG1329@1|root,COG1329@2|Bacteria,1MWI2@1224|Proteobacteria,42RXS@68525|delta/epsilon subdivisions,2WNA0@28221|Deltaproteobacteria,2YVAI@29|Myxococcales	28221|Deltaproteobacteria	K	Transcriptional regulator, CarD family	-	-	-	ko:K07736	-	-	-	-	ko00000,ko03000	-	-	-	CarD_CdnL_TRCF
HKD2_k127_7049780_0	1192034.CAP_5227	2.056e-52	191.0	COG0162@1|root,COG0162@2|Bacteria,1MVUQ@1224|Proteobacteria,42N2A@68525|delta/epsilon subdivisions,2WIP6@28221|Deltaproteobacteria,2YU10@29|Myxococcales	28221|Deltaproteobacteria	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	GO:0003674,GO:0003824,GO:0004812,GO:0004831,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016875,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	S4,tRNA-synt_1b
HKD2_k127_708699_0	378806.STAUR_4371	9.723e-99	329.0	COG0180@1|root,COG0180@2|Bacteria,1MV4T@1224|Proteobacteria,42MCV@68525|delta/epsilon subdivisions,2WJI2@28221|Deltaproteobacteria,2YUV8@29|Myxococcales	28221|Deltaproteobacteria	J	Tryptophanyl-tRNA synthetase	trpS	-	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
HKD2_k127_7095935_0	164757.Mjls_3215	1.829e-89	305.0	COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria,232ME@1762|Mycobacteriaceae	201174|Actinobacteria	IQ	COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
HKD2_k127_7095935_1	391625.PPSIR1_35672	2.411e-88	310.0	COG0823@1|root,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,PA14,PD40,PKD
HKD2_k127_7106802_0	511062.GU3_06635	7.849e-281	881.0	COG0046@1|root,COG0047@1|root,COG0046@2|Bacteria,COG0047@2|Bacteria,1MYN4@1224|Proteobacteria,1RMRN@1236|Gammaproteobacteria,1Y3MV@135624|Aeromonadales	135624|Aeromonadales	F	Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS_C,GATase_5
HKD2_k127_7125433_0	1192034.CAP_6692	4.264e-68	234.0	COG0454@1|root,COG0456@2|Bacteria,1PMA3@1224|Proteobacteria,42PYX@68525|delta/epsilon subdivisions,2WKSE@28221|Deltaproteobacteria,2YUVH@29|Myxococcales	28221|Deltaproteobacteria	K	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7125433_8	215803.DB30_1343	2.217e-28	119.0	COG2010@1|root,COG3748@1|root,COG2010@2|Bacteria,COG3748@2|Bacteria,1PEGU@1224|Proteobacteria,434ZM@68525|delta/epsilon subdivisions,2X93H@28221|Deltaproteobacteria,2Z1PW@29|Myxococcales	28221|Deltaproteobacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7125433_4	76114.ebA4580	4.553e-37	152.0	COG0664@1|root,COG0664@2|Bacteria,1PWSC@1224|Proteobacteria,2W0ID@28216|Betaproteobacteria,2KYBU@206389|Rhodocyclales	206389|Rhodocyclales	K	helix_turn_helix, cAMP Regulatory protein	nnrR	-	-	ko:K21564	-	-	-	-	ko00000,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
HKD2_k127_7125433_3	290397.Adeh_3512	3.407e-40	165.0	COG2846@1|root,COG4309@1|root,COG2846@2|Bacteria,COG4309@2|Bacteria,1PSZK@1224|Proteobacteria,43A90@68525|delta/epsilon subdivisions,2WXQZ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	D	Uncharacterized conserved protein (DUF2249)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2249
HKD2_k127_7125433_9	204669.Acid345_0547	9.362e-21	101.0	COG3945@1|root,COG3945@2|Bacteria,3Y5T8@57723|Acidobacteria,2JNYH@204432|Acidobacteriia	204432|Acidobacteriia	S	Hemerythrin HHE cation binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
HKD2_k127_7125433_12	1126627.BAWE01000002_gene99	6.961e-07	61.0	COG2091@1|root,COG2091@2|Bacteria,1MZHC@1224|Proteobacteria,2UFA4@28211|Alphaproteobacteria,3JSAX@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	H	Belongs to the P-Pant transferase superfamily	MA20_09870	-	-	ko:K06133	ko00770,map00770	-	R01625	RC00002	ko00000,ko00001,ko01000	-	-	-	ACPS
HKD2_k127_7125433_1	1380394.JADL01000001_gene3088	2.004e-61	228.0	COG1612@1|root,COG1612@2|Bacteria,1MVJ4@1224|Proteobacteria,2TR0M@28211|Alphaproteobacteria,2JQ6K@204441|Rhodospirillales	204441|Rhodospirillales	O	Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group	ctaA	-	-	ko:K02259	ko00190,ko00860,ko01100,ko01110,ko02020,ko04714,map00190,map00860,map01100,map01110,map02020,map04714	M00154	R07412	RC00769	ko00000,ko00001,ko00002,ko03029	3.D.4.4	-	-	COX15-CtaA
HKD2_k127_7125433_6	945713.IALB_2677	1.6e-30	132.0	2D6MI@1|root,32TMJ@2|Bacteria	2|Bacteria	S	PAP2 superfamily C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	PAP2_C
HKD2_k127_7125433_5	1121920.AUAU01000006_gene351	4.289e-33	141.0	COG2846@1|root,COG2846@2|Bacteria,3Y4SU@57723|Acidobacteria	57723|Acidobacteria	C	Di-iron-containing protein involved in the repair of iron-sulfur clusters	-	-	-	ko:K07322	-	-	-	-	ko00000	-	-	-	Hemerythrin,ScdA_N
HKD2_k127_7125433_10	1430440.MGMSRv2_1422	2.803e-09	68.0	COG4314@1|root,COG4314@2|Bacteria,1N3G0@1224|Proteobacteria	1224|Proteobacteria	C	lipoprotein involved in nitrous oxide reduction	-	-	-	ko:K19342	-	-	-	-	ko00000	-	-	-	NosL
HKD2_k127_7125433_2	1244869.H261_05834	6.311e-48	187.0	COG1131@1|root,COG1131@2|Bacteria,1MUW7@1224|Proteobacteria,2TR2Q@28211|Alphaproteobacteria	28211|Alphaproteobacteria	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD2_k127_7125433_7	518766.Rmar_2014	2.233e-30	126.0	COG3420@1|root,COG3420@2|Bacteria,4NEGT@976|Bacteroidetes,1FJC4@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	P	Domain present in carbohydrate binding proteins and sugar hydrolses	nosD	-	-	ko:K07218	-	-	-	-	ko00000	-	-	-	NosD
HKD2_k127_7134492_15	644966.Tmar_1075	3.113e-24	111.0	COG0323@1|root,COG0323@2|Bacteria,1TPGK@1239|Firmicutes,24902@186801|Clostridia,3WCFA@538999|Clostridiales incertae sedis	186801|Clostridia	L	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex	mutL	-	-	ko:K03572	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	DNA_mis_repair,HATPase_c_3,MutL_C
HKD2_k127_7134492_4	1192034.CAP_4921	6.269e-152	520.0	COG1520@1|root,COG1520@2|Bacteria	2|Bacteria	S	amino acid activation for nonribosomal peptide biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,PhoD,PhoD_N
HKD2_k127_7134492_7	575540.Isop_0364	1.893e-96	336.0	COG1143@1|root,COG3260@1|root,COG1143@2|Bacteria,COG3260@2|Bacteria,2J033@203682|Planctomycetes	203682|Planctomycetes	C	NADH ubiquinone oxidoreductase, 20 Kd subunit	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Oxidored_q6
HKD2_k127_7134492_0	575540.Isop_0365	5.933e-189	625.0	COG3261@1|root,COG3262@1|root,COG3261@2|Bacteria,COG3262@2|Bacteria,2IZ46@203682|Planctomycetes	203682|Planctomycetes	C	Respiratory-chain NADH dehydrogenase, 30 Kd subunit	-	-	-	-	-	-	-	-	-	-	-	-	Complex1_30kDa,Complex1_49kDa
HKD2_k127_7134492_3	1232410.KI421427_gene1296	1.319e-158	523.0	COG0651@1|root,COG0651@2|Bacteria,1MVBA@1224|Proteobacteria,42MG7@68525|delta/epsilon subdivisions,2WIRA@28221|Deltaproteobacteria,43TR1@69541|Desulfuromonadales	28221|Deltaproteobacteria	CP	Proton-conducting membrane transporter	ehrD	-	-	ko:K12141	-	-	-	-	ko00000,ko01000	-	-	-	Proton_antipo_M
HKD2_k127_7134492_8	269799.Gmet_0373	1.447e-64	228.0	COG4237@1|root,COG4237@2|Bacteria,1NAT8@1224|Proteobacteria,42NDW@68525|delta/epsilon subdivisions,2WMF0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	hydrogenase 4 membrane	-	-	-	ko:K12140	-	-	-	-	ko00000,ko01000	-	-	-	Oxidored_q2
HKD2_k127_7134492_5	398767.Glov_2557	1.787e-121	396.0	COG0650@1|root,COG0650@2|Bacteria,1MXV5@1224|Proteobacteria,42NHI@68525|delta/epsilon subdivisions,2WJ3D@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	NADH dehydrogenase	ehrB	-	-	-	-	-	-	-	-	-	-	iAF987.Gmet_2600	NADHdh
HKD2_k127_7134492_1	1232410.KI421427_gene1299	2.58e-187	635.0	COG0651@1|root,COG0651@2|Bacteria,1MXRW@1224|Proteobacteria,42NFV@68525|delta/epsilon subdivisions,2WJZ0@28221|Deltaproteobacteria,43T2H@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	PFAM NADH Ubiquinone plastoquinone (complex I)	ehrA-2	-	-	ko:K12137	-	-	-	-	ko00000,ko01000	-	-	-	Proton_antipo_M,Proton_antipo_N
HKD2_k127_7134492_2	290397.Adeh_3654	2.764e-162	541.0	COG0651@1|root,COG0651@2|Bacteria,1MXRW@1224|Proteobacteria,42NFV@68525|delta/epsilon subdivisions,2WJZ0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	CP	PFAM NADH Ubiquinone plastoquinone (complex I)	-	-	-	ko:K12137	-	-	-	-	ko00000,ko01000	-	-	-	Proton_antipo_M,Proton_antipo_N
HKD2_k127_7134492_9	886293.Sinac_2883	1.667e-60	220.0	COG1762@1|root,COG3311@1|root,COG1762@2|Bacteria,COG3311@2|Bacteria,2IZFY@203682|Planctomycetes	203682|Planctomycetes	G	PFAM phosphoenolpyruvate-dependent sugar phosphotransferase system EIIA 2	-	-	-	ko:K02806	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	-	-	-	HTH_17,PTS_EIIA_2
HKD2_k127_7134492_11	502025.Hoch_6047	9.524e-45	171.0	COG1762@1|root,COG1762@2|Bacteria	2|Bacteria	G	phosphoenolpyruvate-dependent sugar phosphotransferase system	-	-	2.7.1.202	ko:K02768,ko:K02769,ko:K02770,ko:K02806	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	M00273	R03232	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.2.1	-	-	CBS,HTH_17,Na_H_Exchanger,PTS_EIIA_2
HKD2_k127_7134492_16	290397.Adeh_1505	2.244e-21	104.0	COG0121@1|root,COG0121@2|Bacteria,1MU1J@1224|Proteobacteria,42X0D@68525|delta/epsilon subdivisions,2WT38@28221|Deltaproteobacteria,2YVK1@29|Myxococcales	28221|Deltaproteobacteria	S	Glutamine amidotransferases class-II	-	-	-	-	-	-	-	-	-	-	-	-	GATase_4
HKD2_k127_7134492_12	1254432.SCE1572_37435	2.258e-44	169.0	COG0727@1|root,COG0727@2|Bacteria	2|Bacteria	S	metal cluster binding	-	-	-	-	-	-	-	-	-	-	-	-	CxxCxxCC
HKD2_k127_7134492_13	290397.Adeh_3501	5.043e-33	143.0	COG3511@1|root,COG3511@2|Bacteria	2|Bacteria	M	phospholipase C	-	-	-	-	-	-	-	-	-	-	-	-	Phosphoesterase
HKD2_k127_7134492_6	1192034.CAP_3892	2.07e-104	351.0	COG2866@1|root,COG2866@2|Bacteria,1MUMN@1224|Proteobacteria	1224|Proteobacteria	E	Carboxypeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M14
HKD2_k127_7134492_10	1379270.AUXF01000005_gene713	2.228e-52	201.0	COG0287@1|root,COG1605@1|root,COG0287@2|Bacteria,COG1605@2|Bacteria,1ZT61@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Chorismate mutase type II	-	-	1.3.1.12,5.4.99.5	ko:K14187	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	M00024,M00025	R01715,R01728	RC00125,RC03116	ko00000,ko00001,ko00002,ko01000	-	-	-	CM_2,PDH
HKD2_k127_7145031_4	448385.sce3130	1.787e-69	266.0	COG3291@1|root,COG3291@2|Bacteria,1R7A1@1224|Proteobacteria,42Y4U@68525|delta/epsilon subdivisions,2WU72@28221|Deltaproteobacteria,2YZXW@29|Myxococcales	28221|Deltaproteobacteria	U	IgGFc binding protein	-	-	-	-	-	-	-	-	-	-	-	-	Big_1,IgGFc_binding
HKD2_k127_7145031_1	448385.sce3131	1.278e-131	471.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	VCBS
HKD2_k127_7145031_0	1192034.CAP_3405	6.397e-308	967.0	COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,42MMA@68525|delta/epsilon subdivisions,2WIZB@28221|Deltaproteobacteria,2YUN3@29|Myxococcales	28221|Deltaproteobacteria	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamA	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
HKD2_k127_7145031_3	378806.STAUR_6425	2.144e-76	271.0	COG2271@1|root,COG2271@2|Bacteria,1MWYR@1224|Proteobacteria,42RD4@68525|delta/epsilon subdivisions,2WN11@28221|Deltaproteobacteria,2YU83@29|Myxococcales	28221|Deltaproteobacteria	G	Organic Anion Transporter Polypeptide (OATP) family	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD2_k127_7145031_2	404589.Anae109_2771	3.327e-88	297.0	COG1389@1|root,COG1389@2|Bacteria,1R6T0@1224|Proteobacteria,42YI1@68525|delta/epsilon subdivisions,2WTHV@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	Relaxes both positive and negative superturns and exhibits a strong decatenase activity	top6B	-	5.99.1.3	ko:K03167	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	HATPase_c,HATPase_c_3,Topo-VIb_trans
HKD2_k127_7155002_1	1095769.CAHF01000022_gene143	8.94e-53	208.0	COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,2VIY8@28216|Betaproteobacteria	28216|Betaproteobacteria	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
HKD2_k127_7155002_0	886293.Sinac_3436	7.427e-74	266.0	COG3228@1|root,COG3228@2|Bacteria,2IZES@203682|Planctomycetes	203682|Planctomycetes	S	Belongs to the MtfA family	-	-	-	ko:K09933	-	-	-	-	ko00000,ko01002	-	-	-	Peptidase_M90,SEC-C
HKD2_k127_7192680_7	435591.BDI_0958	7.246e-11	70.0	COG2755@1|root,COG2755@2|Bacteria,4NK39@976|Bacteroidetes,2FMHM@200643|Bacteroidia,22WFB@171551|Porphyromonadaceae	976|Bacteroidetes	E	COG COG2755 Lysophospholipase L1 and related esterases	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL,Lipase_GDSL_2
HKD2_k127_7192680_1	1192034.CAP_8953	6.639e-177	566.0	COG0297@1|root,COG0297@2|Bacteria,1MUGM@1224|Proteobacteria,42MT8@68525|delta/epsilon subdivisions,2WITI@28221|Deltaproteobacteria,2YU1G@29|Myxococcales	28221|Deltaproteobacteria	F	Synthesizes alpha-1,4-glucan chains using ADP-glucose	glgA	-	2.4.1.21	ko:K00703	ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026	M00565	R02421	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT5	-	Glyco_transf_5,Glycos_transf_1
HKD2_k127_7192680_3	1192034.CAP_8954	3.465e-95	342.0	COG0564@1|root,COG0564@2|Bacteria,1MVJ5@1224|Proteobacteria,42MDF@68525|delta/epsilon subdivisions,2X6EH@28221|Deltaproteobacteria,2Z3AS@29|Myxococcales	28221|Deltaproteobacteria	J	Responsible for synthesis of pseudouridine from uracil	-	-	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2
HKD2_k127_7192680_5	1192034.CAP_8956	8.339e-27	119.0	29YZ3@1|root,30KW0@2|Bacteria,1QAV8@1224|Proteobacteria,435BG@68525|delta/epsilon subdivisions,2WZNV@28221|Deltaproteobacteria,2Z2FQ@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7192680_2	1192034.CAP_8957	9.067e-132	430.0	COG1192@1|root,COG1192@2|Bacteria,1QW1T@1224|Proteobacteria,43BRW@68525|delta/epsilon subdivisions,2X72Q@28221|Deltaproteobacteria,2YZTD@29|Myxococcales	28221|Deltaproteobacteria	D	Cellulose biosynthesis protein BcsQ	-	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
HKD2_k127_7192680_0	1192034.CAP_8958	2.154e-228	717.0	COG0138@1|root,COG0138@2|Bacteria,1MUDQ@1224|Proteobacteria,42MV4@68525|delta/epsilon subdivisions,2WKHZ@28221|Deltaproteobacteria,2YTYA@29|Myxococcales	28221|Deltaproteobacteria	F	Bifunctional purine biosynthesis protein PurH	purH	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AICARFT_IMPCHas,MGS
HKD2_k127_7192680_4	448385.sce3644	5.94e-81	276.0	COG0568@1|root,COG0568@2|Bacteria,1PBSF@1224|Proteobacteria,433T8@68525|delta/epsilon subdivisions,2X9VU@28221|Deltaproteobacteria,2YVGG@29|Myxococcales	28221|Deltaproteobacteria	K	Sigma-70, region 4	asgB	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r4
HKD2_k127_7192680_6	1254432.SCE1572_22010	8.41e-25	107.0	COG0789@1|root,COG0789@2|Bacteria,1Q2FZ@1224|Proteobacteria,4382B@68525|delta/epsilon subdivisions,2X3CF@28221|Deltaproteobacteria,2YVED@29|Myxococcales	28221|Deltaproteobacteria	K	MerR HTH family regulatory protein	-	-	-	-	-	-	-	-	-	-	-	-	MerR_1
HKD2_k127_719270_1	1254432.SCE1572_27260	1.381e-91	317.0	COG0515@1|root,COG0515@2|Bacteria	1254432.SCE1572_27260|-	KLT	protein kinase activity	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	-
HKD2_k127_719270_0	1254432.SCE1572_23125	4.349e-173	550.0	COG0476@1|root,COG0607@1|root,COG0476@2|Bacteria,COG0607@2|Bacteria,1MW7H@1224|Proteobacteria,42NEC@68525|delta/epsilon subdivisions,2WK08@28221|Deltaproteobacteria,2YUA5@29|Myxococcales	28221|Deltaproteobacteria	HP	domain protein	moeB1	-	2.7.7.80,2.8.1.11	ko:K21147	ko04122,map04122	-	R07459,R07461	RC00043	ko00000,ko00001,ko01000	-	-	-	Rhodanese,ThiF
HKD2_k127_7247798_1	1096546.WYO_5307	0.0002651	49.0	COG1881@1|root,COG1881@2|Bacteria,1RHPA@1224|Proteobacteria,2UB93@28211|Alphaproteobacteria,1JTA3@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	Phosphatidylethanolamine-binding protein	-	-	-	ko:K06910	-	-	-	-	ko00000	-	-	-	PBP
HKD2_k127_7247798_0	448385.sce7189	3.777e-33	136.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
HKD2_k127_7251382_2	1254432.SCE1572_23515	1.447e-63	220.0	COG3177@1|root,COG3177@2|Bacteria,1Q2H9@1224|Proteobacteria,4383Y@68525|delta/epsilon subdivisions,2X3DX@28221|Deltaproteobacteria,2YVMK@29|Myxococcales	28221|Deltaproteobacteria	S	Fic/DOC family	-	-	-	-	-	-	-	-	-	-	-	-	Fic
HKD2_k127_7251382_0	107636.JQNK01000009_gene1780	4.017e-101	334.0	COG0107@1|root,COG0107@2|Bacteria,1MUS0@1224|Proteobacteria,2TQXD@28211|Alphaproteobacteria,36XVE@31993|Methylocystaceae	28211|Alphaproteobacteria	E	Histidine biosynthesis protein	hisF	GO:0000107,GO:0003674,GO:0003824,GO:0016740,GO:0016757,GO:0016763	-	ko:K02500	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
HKD2_k127_7251382_4	448385.sce5888	4.404e-31	126.0	COG2979@1|root,COG2979@2|Bacteria	2|Bacteria	T	Protein of unknown function (DUF533)	-	-	-	ko:K11962	ko02010,map02010	M00323	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4.4,3.A.1.4.5	-	-	LETM1,TerB
HKD2_k127_7251382_3	1192034.CAP_7867	1.14e-36	142.0	COG0745@1|root,COG0745@2|Bacteria	1192034.CAP_7867|-	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7254183_3	448385.sce1666	1.589e-57	223.0	COG1589@1|root,COG1589@2|Bacteria,1RDX7@1224|Proteobacteria,42VCZ@68525|delta/epsilon subdivisions,2WRVM@28221|Deltaproteobacteria,2YVR5@29|Myxococcales	28221|Deltaproteobacteria	D	Cell division protein FtsQ	ftsQ	-	-	ko:K03589	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036	-	-	-	FtsQ,POTRA_1
HKD2_k127_7254183_0	1254432.SCE1572_10520	2.119e-200	651.0	COG0773@1|root,COG0773@2|Bacteria,1MV68@1224|Proteobacteria,42MMP@68525|delta/epsilon subdivisions,2WK50@28221|Deltaproteobacteria,2YTUP@29|Myxococcales	28221|Deltaproteobacteria	M	Belongs to the MurCDEF family	murC	-	6.3.2.8	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R03193	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
HKD2_k127_7254183_2	1192034.CAP_7157	1.467e-94	321.0	COG0707@1|root,COG0707@2|Bacteria,1MVIB@1224|Proteobacteria,42ME1@68525|delta/epsilon subdivisions,2WJNY@28221|Deltaproteobacteria,2YWEZ@29|Myxococcales	28221|Deltaproteobacteria	M	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)	murG	-	2.4.1.227	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	-	R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011	-	GT28	-	Glyco_tran_28_C,Glyco_transf_28
HKD2_k127_7254183_1	448385.sce1663	4.953e-147	474.0	COG0772@1|root,COG0772@2|Bacteria,1MVDB@1224|Proteobacteria,42MG2@68525|delta/epsilon subdivisions,2WJ01@28221|Deltaproteobacteria,2YTX5@29|Myxococcales	28221|Deltaproteobacteria	D	Belongs to the SEDS family	ftsW	-	-	ko:K03588	ko04112,map04112	-	-	-	ko00000,ko00001,ko02000,ko03036	2.A.103.1	-	-	FTSW_RODA_SPOVE
HKD2_k127_7274102_0	502025.Hoch_3961	3.601e-80	288.0	COG1729@1|root,COG1729@2|Bacteria,1MX82@1224|Proteobacteria,42TQ9@68525|delta/epsilon subdivisions,2WR3B@28221|Deltaproteobacteria	1224|Proteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_6,TPR_8,YfiO
HKD2_k127_7288291_2	1254432.SCE1572_46675	2.589e-31	129.0	COG2969@1|root,COG2969@2|Bacteria,1R39Y@1224|Proteobacteria,43DJU@68525|delta/epsilon subdivisions,2X8R3@28221|Deltaproteobacteria,2YW22@29|Myxococcales	28221|Deltaproteobacteria	S	Stringent starvation protein B	-	-	-	ko:K03600	-	-	-	-	ko00000,ko03021	-	-	-	SspB
HKD2_k127_7288291_0	670487.Ocepr_2129	1.225e-234	737.0	COG0318@1|root,COG0318@2|Bacteria,1WIB8@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	IQ	Acyl-CoA synthetase (AMP-forming) AMP-acid ligase II	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
HKD2_k127_7309521_1	215803.DB30_0946	1.038e-47	191.0	COG2382@1|root,COG2382@2|Bacteria,1QX4D@1224|Proteobacteria,438NV@68525|delta/epsilon subdivisions,2X29M@28221|Deltaproteobacteria,2YXD1@29|Myxococcales	28221|Deltaproteobacteria	P	Putative esterase	-	-	-	-	-	-	-	-	-	-	-	-	Esterase
HKD2_k127_7321856_2	1242864.D187_002247	5.317e-66	228.0	COG0714@1|root,COG0714@2|Bacteria	2|Bacteria	KLT	Associated with various cellular activities	yehL	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_5
HKD2_k127_7321856_3	1206725.BAFU01000061_gene418	2.218e-31	133.0	COG3801@1|root,COG3801@2|Bacteria,2IQGZ@201174|Actinobacteria,4G260@85025|Nocardiaceae	201174|Actinobacteria	S	YjbR	-	-	-	-	-	-	-	-	-	-	-	-	YjbR
HKD2_k127_7321856_4	426114.THI_0284	0.0007889	49.0	COG1846@1|root,COG1846@2|Bacteria,1PC0C@1224|Proteobacteria,2VUH3@28216|Betaproteobacteria	28216|Betaproteobacteria	K	PFAM regulatory protein, MarR	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
HKD2_k127_7321856_0	290397.Adeh_0382	8.996e-168	533.0	COG0136@1|root,COG0136@2|Bacteria,1MUHG@1224|Proteobacteria,42MDM@68525|delta/epsilon subdivisions,2WJ5Y@28221|Deltaproteobacteria,2YXED@29|Myxococcales	28221|Deltaproteobacteria	E	Belongs to the aspartate-semialdehyde dehydrogenase family	asd	-	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
HKD2_k127_7321856_1	35754.JNYJ01000021_gene344	4.015e-138	457.0	COG2425@1|root,COG2425@2|Bacteria,2H2XB@201174|Actinobacteria,4DBG9@85008|Micromonosporales	201174|Actinobacteria	S	protein containing a von Willebrand factor type A (vWA) domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_732467_3	883113.HMPREF9708_00841	2.329e-15	86.0	COG3264@1|root,COG3264@2|Bacteria,1UN4P@1239|Firmicutes,4IU6A@91061|Bacilli,27F6K@186827|Aerococcaceae	91061|Bacilli	M	Conserved TM helix	-	-	-	-	-	-	-	-	-	-	-	-	TM_helix
HKD2_k127_732467_2	404589.Anae109_3258	1.053e-79	272.0	COG0607@1|root,COG0640@1|root,COG0607@2|Bacteria,COG0640@2|Bacteria,1R71B@1224|Proteobacteria,42SBN@68525|delta/epsilon subdivisions,2WP4A@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	PFAM Rhodanese domain protein	-	-	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	HTH_20,HTH_5,Rhodanese
HKD2_k127_732467_0	1415779.JOMH01000001_gene3235	1.569e-202	641.0	COG0477@1|root,COG2814@2|Bacteria,1R2KY@1224|Proteobacteria,1RZ6A@1236|Gammaproteobacteria	1236|Gammaproteobacteria	EGP	Pfam Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD2_k127_732467_1	502025.Hoch_2162	6.356e-109	362.0	COG1233@1|root,COG3349@1|root,COG4638@1|root,COG1233@2|Bacteria,COG3349@2|Bacteria,COG4638@2|Bacteria,1RAVN@1224|Proteobacteria,433WH@68525|delta/epsilon subdivisions,2X3VQ@28221|Deltaproteobacteria,2YX9K@29|Myxococcales	28221|Deltaproteobacteria	Q	FAD dependent oxidoreductase	-	-	-	ko:K09879	ko00906,map00906	-	R07541,R07560,R07857,R07858	RC01901,RC01965	ko00000,ko00001	-	-	-	Amino_oxidase
HKD2_k127_732467_4	1242864.D187_010367	5.25e-06	50.0	COG3349@1|root,COG3349@2|Bacteria,1RAVN@1224|Proteobacteria,433WH@68525|delta/epsilon subdivisions,2X3VQ@28221|Deltaproteobacteria,2YX9K@29|Myxococcales	28221|Deltaproteobacteria	Q	FAD dependent oxidoreductase	-	-	-	ko:K09879	ko00906,map00906	-	R07541,R07560,R07857,R07858	RC01901,RC01965	ko00000,ko00001	-	-	-	Amino_oxidase
HKD2_k127_738809_0	215803.DB30_1002	1.948e-63	222.0	COG0477@1|root,COG0477@2|Bacteria,1MXZ3@1224|Proteobacteria,43BMQ@68525|delta/epsilon subdivisions,2X6ZS@28221|Deltaproteobacteria,2Z3DT@29|Myxococcales	28221|Deltaproteobacteria	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
HKD2_k127_738809_1	420324.KI912074_gene5900	6.344e-42	156.0	COG2723@1|root,COG2723@2|Bacteria,1MWU7@1224|Proteobacteria,2TT4I@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Belongs to the glycosyl hydrolase 1 family	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_1
HKD2_k127_7391177_8	1192034.CAP_0341	1.336e-22	100.0	COG0848@1|root,COG0848@2|Bacteria,1N8FU@1224|Proteobacteria,42WU3@68525|delta/epsilon subdivisions,2WSMD@28221|Deltaproteobacteria,2YW1Y@29|Myxococcales	28221|Deltaproteobacteria	U	Biopolymer transport protein ExbD/TolR	-	-	-	-	-	-	-	-	-	-	-	-	ExbD
HKD2_k127_7391177_5	1042209.HK44_019320	7.174e-51	184.0	COG0599@1|root,COG0599@2|Bacteria,1RK66@1224|Proteobacteria,1RV3Y@1236|Gammaproteobacteria,1YTA3@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	S	Carboxymuconolactone decarboxylase family	-	-	-	-	-	-	-	-	-	-	-	-	CMD
HKD2_k127_7391177_2	1121920.AUAU01000014_gene2803	8.672e-93	328.0	COG1032@1|root,COG1032@2|Bacteria	2|Bacteria	C	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
HKD2_k127_7391177_3	867903.ThesuDRAFT_02182	1.738e-63	247.0	COG0205@1|root,COG0205@2|Bacteria,1TPF4@1239|Firmicutes,248PB@186801|Clostridia,3WCF7@538999|Clostridiales incertae sedis	186801|Clostridia	F	Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis	pfkA	-	2.7.1.11	ko:K00850	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230	M00001,M00345	R00756,R03236,R03237,R03238,R03239,R04779	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000,ko01009,ko03019	-	-	-	PFK
HKD2_k127_7391177_0	1254432.SCE1572_50885	0.0	1041.0	COG0515@1|root,COG2909@1|root,COG0515@2|Bacteria,COG2909@2|Bacteria,1QA6R@1224|Proteobacteria,4393M@68525|delta/epsilon subdivisions,2X49J@28221|Deltaproteobacteria,2YYJG@29|Myxococcales	28221|Deltaproteobacteria	KLT	Family membership	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,Pkinase
HKD2_k127_7391177_6	215803.DB30_3579	6.24e-46	186.0	2ESNI@1|root,33K73@2|Bacteria,1Q2MV@1224|Proteobacteria,4388I@68525|delta/epsilon subdivisions,2X3I7@28221|Deltaproteobacteria,2YW7A@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF2378
HKD2_k127_7391177_7	1278073.MYSTI_05810	2.356e-32	141.0	2AIX1@1|root,319EP@2|Bacteria,1Q2I0@1224|Proteobacteria,4384V@68525|delta/epsilon subdivisions,2X3EW@28221|Deltaproteobacteria,2YVRV@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7391177_9	1894.JOER01000010_gene2242	7.234e-11	74.0	28M5V@1|root,2ZAJJ@2|Bacteria,2GJNZ@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7391177_4	215803.DB30_2280	5.682e-57	214.0	COG2819@1|root,COG2819@2|Bacteria,1RAB4@1224|Proteobacteria,43F1Q@68525|delta/epsilon subdivisions,2X30X@28221|Deltaproteobacteria,2YTX8@29|Myxococcales	28221|Deltaproteobacteria	S	Putative esterase	-	-	-	-	-	-	-	-	-	-	-	-	Esterase
HKD2_k127_7391177_1	502025.Hoch_5958	6.793e-162	571.0	COG0457@1|root,COG0457@2|Bacteria,1PC8F@1224|Proteobacteria,438AR@68525|delta/epsilon subdivisions,2X3K3@28221|Deltaproteobacteria,2YWDI@29|Myxococcales	28221|Deltaproteobacteria	S	Tetratricopeptide repeats	-	-	-	-	-	-	-	-	-	-	-	-	TPR_19
HKD2_k127_7391177_10	644281.MFS40622_1429	0.0008134	46.0	COG2703@1|root,arCOG06577@2157|Archaea,2Y1Y0@28890|Euryarchaeota,23RNA@183939|Methanococci	183939|Methanococci	P	Oxygen-binding protein. May be involved in a storage mechanism or for delivery to oxygen-requiring enzymes. The oxygen- binding site contains two iron atoms	-	-	-	ko:K07216	-	-	-	-	ko00000	-	-	-	Hemerythrin
HKD2_k127_739349_4	608538.HTH_0593	3.986e-20	100.0	COG1186@1|root,COG1186@2|Bacteria,2G3P3@200783|Aquificae	200783|Aquificae	J	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA	prfB	-	-	ko:K02836	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
HKD2_k127_739349_2	502025.Hoch_4908	6.105e-41	163.0	COG3744@1|root,COG3744@2|Bacteria,1NY7K@1224|Proteobacteria,4380D@68525|delta/epsilon subdivisions,2X3AF@28221|Deltaproteobacteria,2YV4N@29|Myxococcales	28221|Deltaproteobacteria	S	PilT protein domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_739349_1	555088.DealDRAFT_3128	2.252e-111	387.0	COG0751@1|root,COG0751@2|Bacteria,1TNZ7@1239|Firmicutes,248RS@186801|Clostridia,42JJX@68298|Syntrophomonadaceae	186801|Clostridia	J	Glycyl-tRNA synthetase beta subunit	glyS	-	6.1.1.14	ko:K01879	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_1,tRNA_synt_2f
HKD2_k127_739349_5	1229909.NSED_05420	1.466e-13	81.0	COG0574@1|root,arCOG01111@2157|Archaea,41SYV@651137|Thaumarchaeota	651137|Thaumarchaeota	G	Pyruvate phosphate dikinase	-	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
HKD2_k127_739349_3	1123228.AUIH01000012_gene58	4.758e-39	162.0	COG0262@1|root,COG0262@2|Bacteria,1RH0P@1224|Proteobacteria,1S5VH@1236|Gammaproteobacteria,1XKE3@135619|Oceanospirillales	135619|Oceanospirillales	H	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis	folA	-	1.5.1.3	ko:K00287	ko00670,ko00790,ko01100,ko01523,map00670,map00790,map01100,map01523	M00126,M00840	R00936,R00937,R00939,R00940,R02235,R02236,R11765	RC00109,RC00110,RC00158	ko00000,ko00001,ko00002,ko01000	-	-	-	DHFR_1
HKD2_k127_739349_0	1509403.GW12_25730	5.168e-123	402.0	COG0207@1|root,COG0207@2|Bacteria,1MUBD@1224|Proteobacteria,1RPYV@1236|Gammaproteobacteria,3NKAC@468|Moraxellaceae	1236|Gammaproteobacteria	F	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis	thyA	GO:0000287,GO:0003674,GO:0003824,GO:0004799,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006220,GO:0006221,GO:0006231,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009157,GO:0009162,GO:0009165,GO:0009176,GO:0009177,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009314,GO:0009394,GO:0009628,GO:0009987,GO:0016740,GO:0016741,GO:0018130,GO:0019438,GO:0019637,GO:0019692,GO:0032259,GO:0034641,GO:0034654,GO:0042083,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046073,GO:0046385,GO:0046483,GO:0046872,GO:0050896,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.1.45	ko:K00560	ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523	M00053	R02101	RC00219,RC00332	ko00000,ko00001,ko00002,ko01000	-	-	iAF1260.b2827,iAPECO1_1312.APECO1_3678,iBWG_1329.BWG_2562,iE2348C_1286.E2348C_3096,iEC042_1314.EC042_3024,iEC55989_1330.EC55989_3103,iECABU_c1320.ECABU_c31240,iECDH10B_1368.ECDH10B_2997,iECDH1ME8569_1439.ECDH1ME8569_2734,iECED1_1282.ECED1_3283,iECH74115_1262.ECH74115_4093,iECIAI1_1343.ECIAI1_2935,iECIAI39_1322.ECIAI39_3246,iECNA114_1301.ECNA114_2885,iECO103_1326.ECO103_3386,iECO111_1330.ECO111_3555,iECO26_1355.ECO26_3899,iECOK1_1307.ECOK1_3231,iECP_1309.ECP_2840,iECS88_1305.ECS88_3122,iECSE_1348.ECSE_3084,iECSF_1327.ECSF_2642,iECSP_1301.ECSP_3779,iECUMN_1333.ECUMN_3154,iECW_1372.ECW_m3069,iECs_1301.ECs3684,iEKO11_1354.EKO11_0914,iETEC_1333.ETEC_3014,iEcDH1_1363.EcDH1_0864,iEcE24377_1341.EcE24377A_3147,iEcSMS35_1347.EcSMS35_2974,iG2583_1286.G2583_3481,iJO1366.b2827,iJR904.b2827,iLF82_1304.LF82_2267,iNRG857_1313.NRG857_13965,iSSON_1240.SSON_2984,iUMN146_1321.UM146_02290,iUMNK88_1353.UMNK88_3511,iUTI89_1310.UTI89_C3229,iWFL_1372.ECW_m3069,iY75_1357.Y75_RS14705,iYL1228.KPN_03236,iZ_1308.Z4144,ic_1306.c3422	Thymidylat_synt
HKD2_k127_7399662_2	290397.Adeh_3744	5.266e-67	233.0	COG2050@1|root,COG2050@2|Bacteria,1RBPE@1224|Proteobacteria,42RKY@68525|delta/epsilon subdivisions,2WNSM@28221|Deltaproteobacteria,2YXUH@29|Myxococcales	28221|Deltaproteobacteria	Q	PFAM thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
HKD2_k127_7399662_0	448385.sce2937	0.0	1161.0	COG0515@1|root,COG0515@2|Bacteria	448385.sce2937|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7399662_5	582402.Hbal_0828	0.0004643	49.0	COG2979@1|root,COG2979@2|Bacteria,1R95E@1224|Proteobacteria,2U3YT@28211|Alphaproteobacteria,43YY5@69657|Hyphomonadaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF533)	-	-	-	-	-	-	-	-	-	-	-	-	DUF533
HKD2_k127_7399662_1	448385.sce3951	5.752e-72	250.0	COG3000@1|root,COG3000@2|Bacteria,1RA8D@1224|Proteobacteria,42XPW@68525|delta/epsilon subdivisions,2WW2Q@28221|Deltaproteobacteria,2YVGC@29|Myxococcales	28221|Deltaproteobacteria	I	Fatty acid hydroxylase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	FA_hydroxylase
HKD2_k127_74472_5	497964.CfE428DRAFT_3827	4.963e-07	61.0	COG3210@1|root,COG4932@1|root,COG3210@2|Bacteria,COG4932@2|Bacteria	2|Bacteria	M	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_74472_3	1166018.FAES_1719	1.912e-18	101.0	COG0823@1|root,COG0823@2|Bacteria,4NIYK@976|Bacteroidetes,47N0H@768503|Cytophagia	976|Bacteroidetes	U	WD40-like Beta Propeller Repeat	-	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40
HKD2_k127_74472_0	1254432.SCE1572_10390	1.035e-136	457.0	COG2303@1|root,COG2303@2|Bacteria,1P9UF@1224|Proteobacteria	1224|Proteobacteria	E	oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GMC_oxred_C,GMC_oxred_N
HKD2_k127_74472_2	1278073.MYSTI_02729	6.081e-78	282.0	COG2935@1|root,COG2935@2|Bacteria,1MW62@1224|Proteobacteria,42N66@68525|delta/epsilon subdivisions,2WQ1W@28221|Deltaproteobacteria,2YVMR@29|Myxococcales	28221|Deltaproteobacteria	O	May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate	ate	-	2.3.2.29	ko:K21420	-	-	R11547,R11548	RC00064	ko00000,ko01000	-	-	-	ATE_C,ATE_N
HKD2_k127_74472_1	1192034.CAP_7142	5.602e-86	300.0	COG2908@1|root,COG2908@2|Bacteria	2|Bacteria	M	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	-	-	3.6.1.54	ko:K03269	ko00540,ko01100,map00540,map01100	M00060	R04549	RC00002	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Metallophos,Metallophos_2
HKD2_k127_747195_5	383372.Rcas_1608	9.683e-21	100.0	COG1743@1|root,COG2852@1|root,COG1743@2|Bacteria,COG2852@2|Bacteria,2G5MZ@200795|Chloroflexi,377J3@32061|Chloroflexia	32061|Chloroflexia	L	Protein of unknown function (DUF1156)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1156
HKD2_k127_747195_1	1254432.SCE1572_33055	1.097e-141	470.0	COG1716@1|root,COG2204@1|root,COG1716@2|Bacteria,COG2204@2|Bacteria	2|Bacteria	T	phosphorelay signal transduction system	-	-	-	ko:K10941,ko:K21405	ko02020,ko02025,ko05111,map02020,map02025,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	FHA,GAF_2,HTH_8,Sigma54_activat,Yop-YscD_cpl
HKD2_k127_747195_3	448385.sce5470	2.016e-58	217.0	COG0515@1|root,COG0515@2|Bacteria	448385.sce5470|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_747195_2	1192034.CAP_4442	5.715e-97	348.0	COG0515@1|root,COG0515@2|Bacteria	1192034.CAP_4442|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_747195_4	882083.SacmaDRAFT_3195	5.355e-37	158.0	COG3118@1|root,COG3118@2|Bacteria,2I2FB@201174|Actinobacteria,4E4MW@85010|Pseudonocardiales	201174|Actinobacteria	O	Belongs to the thioredoxin family	trxA	-	1.8.1.8	ko:K03671,ko:K03672	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko01000,ko03110	-	-	-	Thioredoxin
HKD2_k127_747195_0	1254432.SCE1572_25170	1.692e-175	567.0	COG0111@1|root,COG0111@2|Bacteria,1MU5Z@1224|Proteobacteria,42M1C@68525|delta/epsilon subdivisions,2WIZQ@28221|Deltaproteobacteria,2YUJB@29|Myxococcales	28221|Deltaproteobacteria	C	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family	serA	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
HKD2_k127_747195_6	1219045.BV98_000903	2.061e-15	91.0	COG1409@1|root,COG1409@2|Bacteria,1NS3S@1224|Proteobacteria,2UI1P@28211|Alphaproteobacteria,2KDG9@204457|Sphingomonadales	204457|Sphingomonadales	S	Fibronectin type 3 domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos,Pur_ac_phosph_N
HKD2_k127_7477188_2	1254432.SCE1572_45515	2.82e-22	98.0	COG0457@1|root,COG0457@2|Bacteria	1254432.SCE1572_45515|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7477188_0	1192034.CAP_5888	2.352e-109	364.0	COG0609@1|root,COG0609@2|Bacteria,1MV9W@1224|Proteobacteria,42N28@68525|delta/epsilon subdivisions,2WJVR@28221|Deltaproteobacteria,2Z336@29|Myxococcales	28221|Deltaproteobacteria	P	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily	hemU	-	-	ko:K02015	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	FecCD
HKD2_k127_7477188_1	1192034.CAP_5889	4.458e-82	277.0	COG1521@1|root,COG1521@2|Bacteria,1MUYA@1224|Proteobacteria,42MVZ@68525|delta/epsilon subdivisions,2WJ3N@28221|Deltaproteobacteria,2YTUR@29|Myxococcales	28221|Deltaproteobacteria	F	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis	coaX	-	2.7.1.33	ko:K03525	ko00770,ko01100,map00770,map01100	M00120	R02971,R03018,R04391	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_1986	Pan_kinase
HKD2_k127_748050_0	1242864.D187_002248	2.845e-220	728.0	COG3831@1|root,COG3831@2|Bacteria,1QWC3@1224|Proteobacteria	1224|Proteobacteria	S	Domain of unknown function (DUF4132)	JD73_20480	-	-	-	-	-	-	-	-	-	-	-	DUF4132,WGR
HKD2_k127_748050_1	225937.HP15_2289	2.767e-15	77.0	COG0714@1|root,COG0714@2|Bacteria,1QDUZ@1224|Proteobacteria,1RQGT@1236|Gammaproteobacteria,469BG@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	COG0714 MoxR-like ATPases	yehL	-	-	-	-	-	-	-	-	-	-	-	AAA_5
HKD2_k127_748619_3	1254432.SCE1572_05525	1.702e-25	111.0	COG1287@1|root,COG1287@2|Bacteria	2|Bacteria	S	oligosaccharyl transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_748619_1	448385.sce0784	5.344e-68	237.0	COG0220@1|root,COG0220@2|Bacteria,1MUWJ@1224|Proteobacteria,42M78@68525|delta/epsilon subdivisions,2WRKW@28221|Deltaproteobacteria,2YVUK@29|Myxococcales	28221|Deltaproteobacteria	J	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA	trmB	GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008176,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0034708,GO:0036265,GO:0043170,GO:0043412,GO:0043414,GO:0043527,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0106004,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1990234	2.1.1.33	ko:K03439	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltransf_4
HKD2_k127_748619_0	448385.sce8650	5.724e-219	737.0	COG0457@1|root,COG0515@1|root,COG3899@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG3899@2|Bacteria,1QA6R@1224|Proteobacteria,4393M@68525|delta/epsilon subdivisions,2X49J@28221|Deltaproteobacteria,2YYJG@29|Myxococcales	28221|Deltaproteobacteria	KLT	Family membership	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,Pkinase
HKD2_k127_748619_2	1192034.CAP_8441	1.81e-27	124.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,42RC9@68525|delta/epsilon subdivisions,2WN5U@28221|Deltaproteobacteria,2YWJ8@29|Myxococcales	28221|Deltaproteobacteria	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PEGA,Pkinase
HKD2_k127_7522623_0	502025.Hoch_4976	5.956e-82	289.0	COG3372@1|root,COG3372@2|Bacteria,1NVX4@1224|Proteobacteria,4385X@68525|delta/epsilon subdivisions,2X3FQ@28221|Deltaproteobacteria,2YVWR@29|Myxococcales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF790)	-	-	-	ko:K09744	-	-	-	-	ko00000	-	-	-	DUF790
HKD2_k127_7522623_1	1122603.ATVI01000007_gene1801	1.219e-76	261.0	COG1297@1|root,COG1297@2|Bacteria,1N7SK@1224|Proteobacteria,1RNC8@1236|Gammaproteobacteria,1X4Q2@135614|Xanthomonadales	135614|Xanthomonadales	S	transporter	-	-	-	-	-	-	-	-	-	-	-	-	OPT
HKD2_k127_7540356_2	1192034.CAP_0095	3.78e-59	208.0	COG0341@1|root,COG0341@2|Bacteria,1MU74@1224|Proteobacteria,42M2H@68525|delta/epsilon subdivisions,2WJ8I@28221|Deltaproteobacteria,2YUZD@29|Myxococcales	28221|Deltaproteobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secF	-	-	ko:K03074	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
HKD2_k127_7540356_3	937777.Deipe_0709	9.562e-23	108.0	COG3221@1|root,COG3221@2|Bacteria,1WIG6@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	P	TIGRFAM phosphate phosphite phosphonate ABC transporters, periplasmic binding protein	-	-	-	ko:K02044	ko02010,map02010	M00223	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.9	-	-	Phosphonate-bd
HKD2_k127_7540356_0	1254432.SCE1572_27325	5.067e-98	326.0	COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,42NTG@68525|delta/epsilon subdivisions,2X5CT@28221|Deltaproteobacteria,2YV0W@29|Myxococcales	28221|Deltaproteobacteria	Q	ABC transporter	-	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
HKD2_k127_7540356_1	1254432.SCE1572_27320	1.087e-74	265.0	COG1463@1|root,COG1463@2|Bacteria,1MY8D@1224|Proteobacteria,42TCA@68525|delta/epsilon subdivisions,2WP6I@28221|Deltaproteobacteria,2YVND@29|Myxococcales	28221|Deltaproteobacteria	Q	ABC-type transport system involved in resistance to organic solvents periplasmic component	-	-	-	ko:K02067	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaD
HKD2_k127_7567099_3	1254432.SCE1572_07390	2.471e-49	188.0	COG0438@1|root,COG0438@2|Bacteria,1NU0D@1224|Proteobacteria,431K6@68525|delta/epsilon subdivisions,2WWVM@28221|Deltaproteobacteria,2Z1M9@29|Myxococcales	28221|Deltaproteobacteria	M	Glycosyltransferase Family 4	-	-	-	ko:K14335	-	-	-	-	ko00000,ko01000,ko01003	-	GT4	-	Glyco_transf_4,Glycos_transf_1
HKD2_k127_7567099_4	392499.Swit_1811	5.53e-29	124.0	COG3233@1|root,COG3233@2|Bacteria,1RIED@1224|Proteobacteria,2VERK@28211|Alphaproteobacteria,2KDTE@204457|Sphingomonadales	204457|Sphingomonadales	S	Uncharacterized protein conserved in bacteria (DUF2334)	-	-	-	ko:K06986	-	-	-	-	ko00000	-	-	-	DUF2334
HKD2_k127_7567099_0	448385.sce1029	5.803e-273	884.0	COG1033@1|root,COG4258@1|root,COG1033@2|Bacteria,COG4258@2|Bacteria,1QX7Z@1224|Proteobacteria,43C13@68525|delta/epsilon subdivisions,2X7BR@28221|Deltaproteobacteria,2YU55@29|Myxococcales	28221|Deltaproteobacteria	S	MMPL family	-	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
HKD2_k127_7567099_1	883078.HMPREF9695_00525	4.41e-109	367.0	COG0438@1|root,COG0438@2|Bacteria,1NB81@1224|Proteobacteria,2U269@28211|Alphaproteobacteria,3JTXS@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
HKD2_k127_7567099_5	671143.DAMO_0200	1.492e-05	59.0	COG0728@1|root,COG0728@2|Bacteria,2NNX8@2323|unclassified Bacteria	2|Bacteria	U	Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane	-	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
HKD2_k127_7567099_2	663932.KB902575_gene713	1.22e-83	299.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
HKD2_k127_7569372_0	1463887.KL590002_gene4192	1.287e-42	164.0	COG0346@1|root,COG0346@2|Bacteria,2II0X@201174|Actinobacteria	201174|Actinobacteria	E	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HKD2_k127_7569372_2	1254432.SCE1572_08380	2.063e-06	62.0	COG1633@1|root,COG1633@2|Bacteria	2|Bacteria	S	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)	-	-	4.1.99.5	ko:K14331	-	-	-	-	ko00000,ko01000	-	-	-	MiaE_2
HKD2_k127_7569372_1	448385.sce6840	2.656e-35	156.0	COG0457@1|root,COG0515@1|root,COG3899@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG3899@2|Bacteria,1QA6R@1224|Proteobacteria	1224|Proteobacteria	KLT	serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,Pkinase
HKD2_k127_7604401_7	448385.sce6488	5.266e-20	106.0	COG1058@1|root,COG1058@2|Bacteria,1MVG6@1224|Proteobacteria,42R50@68525|delta/epsilon subdivisions,2X3AE@28221|Deltaproteobacteria,2YV4E@29|Myxococcales	28221|Deltaproteobacteria	S	nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA	-	-	-	-	-	-	-	-	-	-	-	-	MoCF_biosynth
HKD2_k127_7604401_6	448385.sce1593	1.426e-33	138.0	COG0745@1|root,COG0745@2|Bacteria,1N1TA@1224|Proteobacteria,42V03@68525|delta/epsilon subdivisions,2WPZR@28221|Deltaproteobacteria,2YVV2@29|Myxococcales	28221|Deltaproteobacteria	T	Chemotaxis protein CheY	cheY40H-1	-	-	ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	Response_reg
HKD2_k127_7604401_0	1254432.SCE1572_10140	2.956e-234	751.0	COG0643@1|root,COG2198@1|root,COG0643@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,42M6Q@68525|delta/epsilon subdivisions,2WJ5U@28221|Deltaproteobacteria,2YU8D@29|Myxococcales	28221|Deltaproteobacteria	NT	Signal transducing histidine kinase, homodimeric domain	cheA40H	-	2.7.13.3	ko:K03407	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt
HKD2_k127_7604401_5	448385.sce1595	4.069e-34	153.0	COG0835@1|root,COG0835@2|Bacteria,1PEGB@1224|Proteobacteria,43466@68525|delta/epsilon subdivisions,2X1U3@28221|Deltaproteobacteria,2YYW0@29|Myxococcales	28221|Deltaproteobacteria	NT	Two component signalling adaptor domain	-	-	-	ko:K03408	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheW
HKD2_k127_7604401_4	448385.sce1596	6.592e-40	153.0	COG0835@1|root,COG0835@2|Bacteria,1RAH1@1224|Proteobacteria,42S69@68525|delta/epsilon subdivisions,2X5TT@28221|Deltaproteobacteria,2Z060@29|Myxococcales	28221|Deltaproteobacteria	NT	Two component signalling adaptor domain	cheW	-	-	ko:K03408	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheW
HKD2_k127_7604401_3	1192034.CAP_0920	5.045e-47	192.0	COG1413@1|root,COG1413@2|Bacteria,1N55Z@1224|Proteobacteria,42Q7F@68525|delta/epsilon subdivisions,2WPWV@28221|Deltaproteobacteria,2YWMA@29|Myxococcales	28221|Deltaproteobacteria	C	HEAT repeat	-	-	-	-	-	-	-	-	-	-	-	-	HEAT,HEAT_2,HEAT_PBS
HKD2_k127_7604401_1	448385.sce1598	1.265e-101	347.0	COG1352@1|root,COG1352@2|Bacteria,1MU6W@1224|Proteobacteria,42QPJ@68525|delta/epsilon subdivisions,2WMNM@28221|Deltaproteobacteria,2YUW4@29|Myxococcales	28221|Deltaproteobacteria	H	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP	cheR40H-1	-	2.1.1.80	ko:K00575	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko01000,ko02035	-	-	-	CheR,CheR_N
HKD2_k127_7604401_2	1192034.CAP_0922	1.923e-47	171.0	COG2201@1|root,COG2201@2|Bacteria,1MWCN@1224|Proteobacteria,42M27@68525|delta/epsilon subdivisions,2X5MZ@28221|Deltaproteobacteria,2Z36F@29|Myxococcales	28221|Deltaproteobacteria	J	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR	-	-	3.1.1.61,3.5.1.44	ko:K03412	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest,Response_reg
HKD2_k127_76160_1	313612.L8106_00900	2.098e-24	121.0	COG0642@1|root,COG0745@1|root,COG2202@1|root,COG2461@1|root,COG5002@1|root,COG0745@2|Bacteria,COG2202@2|Bacteria,COG2205@2|Bacteria,COG2461@2|Bacteria,COG5002@2|Bacteria,1G09B@1117|Cyanobacteria,1H7T9@1150|Oscillatoriales	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4118,GAF,GAF_2,HATPase_c,HisKA,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg
HKD2_k127_76160_2	221288.JH992901_gene4378	2.154e-18	101.0	COG0642@1|root,COG2199@1|root,COG2202@1|root,COG5000@1|root,COG2202@2|Bacteria,COG2205@2|Bacteria,COG3706@2|Bacteria,COG5000@2|Bacteria,1G4EI@1117|Cyanobacteria,1JJY7@1189|Stigonemataceae	1117|Cyanobacteria	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GGDEF
HKD2_k127_76160_0	1192034.CAP_8836	3.482e-175	567.0	COG1226@1|root,COG4651@1|root,COG1226@2|Bacteria,COG4651@2|Bacteria,1MV34@1224|Proteobacteria,42MEM@68525|delta/epsilon subdivisions,2WK23@28221|Deltaproteobacteria,2YX01@29|Myxococcales	28221|Deltaproteobacteria	P	Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family	-	-	-	ko:K03455	-	-	-	-	ko00000	2.A.37	-	-	Na_H_Exchanger,TrkA_C,TrkA_N
HKD2_k127_76160_3	1267535.KB906767_gene5296	9.154e-08	64.0	COG3240@1|root,COG3240@2|Bacteria	2|Bacteria	I	lipase activity	-	-	-	ko:K15349	ko05132,map05132	-	-	-	ko00000,ko00001	-	-	-	Big_3_5,Lipase_GDSL,Lipase_GDSL_2
HKD2_k127_76160_4	1487953.JMKF01000045_gene2926	3.655e-07	63.0	COG1073@1|root,COG1073@2|Bacteria,1GBEW@1117|Cyanobacteria	1117|Cyanobacteria	S	alpha beta	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7622897_0	448385.sce3129	6.344e-114	372.0	COG0249@1|root,COG0249@2|Bacteria,1MUGX@1224|Proteobacteria,42MRR@68525|delta/epsilon subdivisions,2WIQ7@28221|Deltaproteobacteria,2YTZJ@29|Myxococcales	28221|Deltaproteobacteria	L	that it carries out the mismatch recognition step. This protein has a weak ATPase activity	mutS	GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
HKD2_k127_7622897_2	246197.MXAN_4993	4.948e-17	92.0	COG0697@1|root,COG0697@2|Bacteria,1Q97J@1224|Proteobacteria,43417@68525|delta/epsilon subdivisions,2X4KS@28221|Deltaproteobacteria,2YZ7S@29|Myxococcales	28221|Deltaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HKD2_k127_7622897_1	1192034.CAP_4064	2.822e-33	135.0	COG3291@1|root,COG3291@2|Bacteria	2|Bacteria	S	metallopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	CBM60,CHU_C,Glyco_hydro_8,IgGFc_binding,PA14,PKD,PQQ,PQQ_2,fn3
HKD2_k127_76275_2	529709.PYCH_01160	1.148e-18	100.0	COG0534@1|root,arCOG01731@2157|Archaea,2XUU4@28890|Euryarchaeota,242ZQ@183968|Thermococci	183968|Thermococci	V	MatE	-	-	-	-	-	-	-	-	-	-	-	-	MatE
HKD2_k127_76275_1	909663.KI867150_gene1046	8.102e-20	101.0	COG2006@1|root,COG2006@2|Bacteria,1QMGX@1224|Proteobacteria,42PRJ@68525|delta/epsilon subdivisions,2WMFN@28221|Deltaproteobacteria,2MQHV@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
HKD2_k127_76275_0	1254432.SCE1572_07790	3.853e-159	526.0	COG0348@1|root,COG1143@1|root,COG0348@2|Bacteria,COG1143@2|Bacteria,1MY5M@1224|Proteobacteria,43BPV@68525|delta/epsilon subdivisions,2WJVS@28221|Deltaproteobacteria,2YW51@29|Myxococcales	28221|Deltaproteobacteria	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_5,Fer4_7
HKD2_k127_7647303_0	1089550.ATTH01000001_gene2299	3.12e-77	270.0	COG1028@1|root,COG1028@2|Bacteria,4NGQY@976|Bacteroidetes	976|Bacteroidetes	IQ	Short-chain dehydrogenase reductase sdr	-	-	1.1.1.401	ko:K21883	ko00051,ko01120,map00051,map01120	-	R11339	RC00089	ko00000,ko00001,ko01000	-	-	-	adh_short_C2
HKD2_k127_7649081_0	1192034.CAP_1704	6.344e-176	568.0	COG4962@1|root,COG4962@2|Bacteria,1R7SU@1224|Proteobacteria,42PWC@68525|delta/epsilon subdivisions,2WM34@28221|Deltaproteobacteria,2YWC1@29|Myxococcales	28221|Deltaproteobacteria	U	Type II/IV secretion system protein	-	-	-	ko:K02283	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
HKD2_k127_7667937_0	1144275.COCOR_06733	1.005e-49	184.0	COG0642@1|root,COG2203@1|root,COG3829@1|root,COG2203@2|Bacteria,COG2205@2|Bacteria,COG3829@2|Bacteria,1MXH7@1224|Proteobacteria,43AYG@68525|delta/epsilon subdivisions	1224|Proteobacteria	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	2.7.13.3	ko:K07636	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
HKD2_k127_7669210_1	448385.sce1756	2.067e-38	147.0	COG0824@1|root,COG0824@2|Bacteria,1Q2J2@1224|Proteobacteria,433TX@68525|delta/epsilon subdivisions,2X3FR@28221|Deltaproteobacteria,2YVWT@29|Myxococcales	28221|Deltaproteobacteria	S	Thioesterase-like superfamily	-	-	3.1.2.23	ko:K01075	ko00130,ko00362,ko01100,ko01110,ko01120,map00130,map00362,map01100,map01110,map01120	-	R01301	RC00004,RC00174	ko00000,ko00001,ko01000	-	-	-	4HBT
HKD2_k127_7669210_0	272560.BPSS1998	2.105e-187	617.0	COG3391@1|root,COG3391@2|Bacteria,1R6BZ@1224|Proteobacteria,2W3VQ@28216|Betaproteobacteria,1K364@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Phosphoesterase family	-	-	-	-	-	-	-	-	-	-	-	-	Lactonase,Phosphoesterase
HKD2_k127_7670831_1	448385.sce8018	4.63e-65	249.0	COG0515@1|root,COG0515@2|Bacteria	448385.sce8018|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7670831_2	502025.Hoch_4606	3.779e-60	229.0	COG1524@1|root,COG1524@2|Bacteria,1R5V5@1224|Proteobacteria	1224|Proteobacteria	P	Alkaline phosphatase with broad substrate specificity	phoK	-	3.1.3.1	ko:K01077	ko00730,ko00790,ko01100,ko02020,map00730,map00790,map01100,map02020	M00126	R02135,R04620	RC00017	ko00000,ko00001,ko00002,ko00537,ko01000,ko04147	-	-	-	Phosphodiest
HKD2_k127_7670831_0	1254432.SCE1572_50885	1.738e-282	906.0	COG0515@1|root,COG2909@1|root,COG0515@2|Bacteria,COG2909@2|Bacteria,1QA6R@1224|Proteobacteria,4393M@68525|delta/epsilon subdivisions,2X49J@28221|Deltaproteobacteria,2YYJG@29|Myxococcales	28221|Deltaproteobacteria	KLT	Family membership	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,Pkinase
HKD2_k127_7676649_1	870187.Thini_3044	5.749e-29	130.0	COG2010@1|root,COG2863@1|root,COG2010@2|Bacteria,COG2863@2|Bacteria,1QWZP@1224|Proteobacteria,1T31A@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Protein of unknown function (DUF1595)	-	-	-	-	-	-	-	-	-	-	-	-	CBM_2,Cytochrome_CBB3,PSCyt3,PSD2,PSD3,PSD4,PSD5
HKD2_k127_7676649_2	1125863.JAFN01000001_gene614	8.99e-19	100.0	COG0132@1|root,COG0132@2|Bacteria,1RDRK@1224|Proteobacteria,42SQE@68525|delta/epsilon subdivisions,2WPQK@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring	bioD	-	6.3.3.3	ko:K01935	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03182	RC00868	ko00000,ko00001,ko00002,ko01000	-	-	-	AAA_26
HKD2_k127_7676649_0	1121918.ARWE01000001_gene2288	7.649e-122	403.0	COG0442@1|root,COG0442@2|Bacteria,1MU7E@1224|Proteobacteria,42ME5@68525|delta/epsilon subdivisions,2WKA2@28221|Deltaproteobacteria,43RZR@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Aminoacyl-tRNA editing domain	proS	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA_edit
HKD2_k127_7684616_0	661478.OP10G_4340	1.742e-68	250.0	COG2211@1|root,COG2211@2|Bacteria	2|Bacteria	G	Major facilitator Superfamily	-	-	-	ko:K16210	-	-	-	-	ko00000,ko02000	2.A.2.5	-	-	MFS_1,MFS_2,Peripla_BP_3
HKD2_k127_7684616_1	1206729.BAFZ01000041_gene4553	3.618e-59	229.0	2ANI9@1|root,31DH5@2|Bacteria,2GJE8@201174|Actinobacteria,4FZE9@85025|Nocardiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7684616_4	452652.KSE_11470	1.57e-13	82.0	COG0501@1|root,COG0501@2|Bacteria,2GKJQ@201174|Actinobacteria,2M0BB@2063|Kitasatospora	201174|Actinobacteria	O	Peptidase family M48	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
HKD2_k127_7684616_2	502025.Hoch_1339	1.153e-53	196.0	COG2197@1|root,COG2197@2|Bacteria,1RDUR@1224|Proteobacteria	1224|Proteobacteria	KT	COG2771 DNA-binding HTH domain-containing proteins	-	-	-	-	-	-	-	-	-	-	-	-	GerE
HKD2_k127_7684616_3	502025.Hoch_1338	2.383e-53	199.0	2FGT4@1|root,348NF@2|Bacteria,1QAAV@1224|Proteobacteria,434Y1@68525|delta/epsilon subdivisions,2WZ8V@28221|Deltaproteobacteria,2Z1KQ@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7685785_1	1192034.CAP_3998	3.42e-147	475.0	COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,42Z0F@68525|delta/epsilon subdivisions,2WTWA@28221|Deltaproteobacteria,2YUMY@29|Myxococcales	28221|Deltaproteobacteria	I	AMP-binding enzyme	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
HKD2_k127_7685785_9	1298858.AUEL01000013_gene5070	1.44e-16	88.0	COG2020@1|root,COG2020@2|Bacteria,1RBFX@1224|Proteobacteria,2U68D@28211|Alphaproteobacteria,43Q04@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	O	Isoprenylcysteine carboxyl methyltransferase (ICMT) family	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
HKD2_k127_7685785_8	1254432.SCE1572_28535	5.067e-19	101.0	COG5549@1|root,COG5549@2|Bacteria,1PC02@1224|Proteobacteria,433UB@68525|delta/epsilon subdivisions,2X3H4@28221|Deltaproteobacteria,2YW2B@29|Myxococcales	28221|Deltaproteobacteria	O	Matrixin	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M10
HKD2_k127_7685785_5	448385.sce3482	7.05e-44	168.0	COG1595@1|root,COG1595@2|Bacteria,1Q4ZI@1224|Proteobacteria,42TYH@68525|delta/epsilon subdivisions,2WQNG@28221|Deltaproteobacteria,2YYP8@29|Myxococcales	28221|Deltaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	carQ	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
HKD2_k127_7685785_7	448385.sce3481	1.276e-24	113.0	2AGMF@1|root,316UN@2|Bacteria,1PY1C@1224|Proteobacteria,43E04@68525|delta/epsilon subdivisions,2WZBK@28221|Deltaproteobacteria,2Z1SE@29|Myxococcales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF1109)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1109
HKD2_k127_7685785_2	404589.Anae109_0139	1.41e-95	336.0	COG0297@1|root,COG0297@2|Bacteria,1MUGM@1224|Proteobacteria,42MT8@68525|delta/epsilon subdivisions,2WITI@28221|Deltaproteobacteria,2YU1G@29|Myxococcales	28221|Deltaproteobacteria	F	Synthesizes alpha-1,4-glucan chains using ADP-glucose	glgA	GO:0000271,GO:0003674,GO:0003824,GO:0004373,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0008194,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0035251,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046527,GO:0055114,GO:0071704,GO:1901576	2.4.1.21	ko:K00703	ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026	M00565	R02421	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT5	-	Glyco_transf_5,Glycos_transf_1
HKD2_k127_7685785_3	448385.sce5912	1.054e-57	205.0	COG1670@1|root,COG1670@2|Bacteria	2|Bacteria	J	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
HKD2_k127_7685785_10	378806.STAUR_2495	6.122e-11	74.0	COG3299@1|root,COG3299@2|Bacteria,1MWKI@1224|Proteobacteria,42MUS@68525|delta/epsilon subdivisions,2WKK4@28221|Deltaproteobacteria,2YZBQ@29|Myxococcales	28221|Deltaproteobacteria	S	Baseplate J-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Baseplate_J
HKD2_k127_7685785_6	1123242.JH636436_gene523	2.575e-28	132.0	COG1413@1|root,COG3303@1|root,COG1413@2|Bacteria,COG3303@2|Bacteria,2J0SN@203682|Planctomycetes	203682|Planctomycetes	C	Cytochrome c554 and c-prime	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554
HKD2_k127_7685785_0	1379270.AUXF01000002_gene1526	3.677e-280	883.0	COG3968@1|root,COG3968@2|Bacteria,1ZSPJ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Glutamine synthetase type III N terminal	-	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	GSIII_N,Gln-synt_C
HKD2_k127_7685785_4	1192034.CAP_6692	3.078e-53	190.0	COG0454@1|root,COG0456@2|Bacteria,1PMA3@1224|Proteobacteria,42PYX@68525|delta/epsilon subdivisions,2WKSE@28221|Deltaproteobacteria,2YUVH@29|Myxococcales	28221|Deltaproteobacteria	K	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7690372_0	518766.Rmar_1948	1.944e-146	478.0	COG3033@1|root,COG3033@2|Bacteria,4NEP4@976|Bacteroidetes,1FJ19@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	E	Beta-eliminating lyase	tnaA	-	4.1.99.1	ko:K01667	ko00380,map00380	-	R00673	RC00209,RC00355	ko00000,ko00001,ko01000	-	-	-	Beta_elim_lyase
HKD2_k127_7690372_3	215803.DB30_3835	1.553e-38	148.0	28QQ1@1|root,2ZD5J@2|Bacteria,1QPY8@1224|Proteobacteria,439MX@68525|delta/epsilon subdivisions,2X4Z5@28221|Deltaproteobacteria,2YZVK@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7690372_1	502025.Hoch_5018	7.143e-125	417.0	COG0451@1|root,COG0451@2|Bacteria,1N8PG@1224|Proteobacteria,42TCH@68525|delta/epsilon subdivisions,2WPEI@28221|Deltaproteobacteria,2YUC8@29|Myxococcales	28221|Deltaproteobacteria	GM	RmlD substrate binding domain	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
HKD2_k127_7690372_2	448385.sce6495	5.068e-95	315.0	COG0204@1|root,COG0204@2|Bacteria,1R9IG@1224|Proteobacteria,42T29@68525|delta/epsilon subdivisions,2WPJ8@28221|Deltaproteobacteria,2YU1X@29|Myxococcales	28221|Deltaproteobacteria	I	Phosphate acyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Acyltransferase
HKD2_k127_7693059_8	1192034.CAP_5288	1.952e-35	139.0	COG1253@1|root,COG1253@2|Bacteria,1MV3P@1224|Proteobacteria,42QX1@68525|delta/epsilon subdivisions,2WMNH@28221|Deltaproteobacteria,2Z2XP@29|Myxococcales	28221|Deltaproteobacteria	S	Transporter associated domain	corC	-	-	ko:K06189	-	-	-	-	ko00000,ko02000	9.A.40.1.2	-	-	CBS,CorC_HlyC,DUF21
HKD2_k127_7693059_3	189425.PGRAT_00335	6.764e-79	272.0	COG0512@1|root,COG0512@2|Bacteria,1TT9R@1239|Firmicutes,4H9XP@91061|Bacilli,26SGI@186822|Paenibacillaceae	91061|Bacilli	EH	with TrpE catalyzes the formation of anthranilate and glutamate from chorismate and glutamine	pabA	-	2.6.1.85,4.1.3.27	ko:K01658,ko:K01664	ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986,R01716	RC00010,RC01418,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
HKD2_k127_7693059_1	1121468.AUBR01000014_gene2225	7.567e-82	289.0	COG0547@1|root,COG0547@2|Bacteria,1TP8U@1239|Firmicutes,247WY@186801|Clostridia,42EK5@68295|Thermoanaerobacterales	186801|Clostridia	F	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)	trpD	-	2.4.2.18,4.1.3.27	ko:K00766,ko:K13497	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R00985,R00986,R01073	RC00010,RC00440,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3
HKD2_k127_7693059_6	404589.Anae109_0373	2.879e-38	155.0	COG0134@1|root,COG0134@2|Bacteria,1MW5K@1224|Proteobacteria,42MAG@68525|delta/epsilon subdivisions,2WM94@28221|Deltaproteobacteria,2YV8U@29|Myxococcales	28221|Deltaproteobacteria	E	Belongs to the TrpC family	trpC	-	4.1.1.48,5.3.1.24	ko:K01609,ko:K13498	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03508,R03509	RC00944,RC00945	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2494	IGPS
HKD2_k127_7693059_0	1192034.CAP_3429	7.111e-95	319.0	COG4974@1|root,COG4974@2|Bacteria,1MVNF@1224|Proteobacteria,42N0M@68525|delta/epsilon subdivisions,2WJ7D@28221|Deltaproteobacteria,2YZDB@29|Myxococcales	28221|Deltaproteobacteria	D	Phage integrase, N-terminal SAM-like domain	xerD	-	-	ko:K03733,ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
HKD2_k127_7693059_2	1192034.CAP_3428	4.083e-81	278.0	COG3741@1|root,COG3741@2|Bacteria,1MY4D@1224|Proteobacteria,43EZM@68525|delta/epsilon subdivisions,2X2S3@28221|Deltaproteobacteria,2Z1PB@29|Myxococcales	28221|Deltaproteobacteria	E	N-formylglutamate amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	FGase
HKD2_k127_7693059_9	1192034.CAP_3426	9.691e-34	130.0	COG0227@1|root,COG0227@2|Bacteria,1MZ57@1224|Proteobacteria,437HJ@68525|delta/epsilon subdivisions,2WSUJ@28221|Deltaproteobacteria,2YW0Q@29|Myxococcales	28221|Deltaproteobacteria	J	Belongs to the bacterial ribosomal protein bL28 family	rpmB	-	-	ko:K02902	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L28
HKD2_k127_7693059_7	1192034.CAP_3424	3.157e-37	161.0	COG1801@1|root,COG1801@2|Bacteria	2|Bacteria	L	Protein of unknown function DUF72	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
HKD2_k127_7693059_4	1192034.CAP_8062	1.482e-66	239.0	COG1560@1|root,COG1560@2|Bacteria,1R03A@1224|Proteobacteria,43CQI@68525|delta/epsilon subdivisions,2X7XZ@28221|Deltaproteobacteria,2Z27Y@29|Myxococcales	28221|Deltaproteobacteria	M	Bacterial lipid A biosynthesis acyltransferase	-	-	2.3.1.241	ko:K02517	ko00540,ko01100,map00540,map01100	M00060	R05146	RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Lip_A_acyltrans
HKD2_k127_7693059_5	1254432.SCE1572_21550	5.044e-53	200.0	COG2304@1|root,COG2304@2|Bacteria	2|Bacteria	IU	oxidoreductase activity	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VWA,VWA_2
HKD2_k127_7700433_4	1254432.SCE1572_07790	7.255e-75	252.0	COG0348@1|root,COG1143@1|root,COG0348@2|Bacteria,COG1143@2|Bacteria,1MY5M@1224|Proteobacteria,43BPV@68525|delta/epsilon subdivisions,2WJVS@28221|Deltaproteobacteria,2YW51@29|Myxococcales	28221|Deltaproteobacteria	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_5,Fer4_7
HKD2_k127_7700433_6	398525.KB900701_gene824	2.947e-39	166.0	2BSG2@1|root,32MI6@2|Bacteria,1R8QW@1224|Proteobacteria,2U2VW@28211|Alphaproteobacteria,3JX8X@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7700433_1	448385.sce1768	4.502e-123	409.0	2A4SI@1|root,30TDY@2|Bacteria,1PD6V@1224|Proteobacteria,435EQ@68525|delta/epsilon subdivisions,2X98Q@28221|Deltaproteobacteria,2Z2N2@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7700433_2	1254432.SCE1572_09660	3.334e-115	389.0	2A4SI@1|root,30TDY@2|Bacteria,1PD6V@1224|Proteobacteria,435EQ@68525|delta/epsilon subdivisions,2X98Q@28221|Deltaproteobacteria,2Z2N2@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7700433_0	1254432.SCE1572_46550	8.986e-158	504.0	COG0407@1|root,COG0407@2|Bacteria,1MUG1@1224|Proteobacteria,42MV9@68525|delta/epsilon subdivisions,2WJZK@28221|Deltaproteobacteria,2YTSB@29|Myxococcales	28221|Deltaproteobacteria	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	hemE	GO:0003674,GO:0003824,GO:0004853,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_0016	URO-D
HKD2_k127_7700433_5	448385.sce1682	8.416e-59	214.0	COG0276@1|root,COG0276@2|Bacteria,1MVR1@1224|Proteobacteria,42M0C@68525|delta/epsilon subdivisions,2WMJ2@28221|Deltaproteobacteria,2Z21X@29|Myxococcales	28221|Deltaproteobacteria	H	Catalyzes the ferrous insertion into protoporphyrin IX	hemH	GO:0003674,GO:0003824,GO:0004325,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.99.1.1,4.99.1.9	ko:K01772	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R00310,R11329	RC01012	ko00000,ko00001,ko00002,ko01000	-	-	-	Ferrochelatase
HKD2_k127_7700433_3	1192034.CAP_7270	5.114e-77	278.0	COG1232@1|root,COG1232@2|Bacteria,1R0KQ@1224|Proteobacteria,42NBG@68525|delta/epsilon subdivisions,2WKMN@28221|Deltaproteobacteria,2YUWM@29|Myxococcales	28221|Deltaproteobacteria	H	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX	hemY	-	1.3.3.15,1.3.3.4	ko:K00231	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03222,R04178	RC00885	ko00000,ko00001,ko00002,ko01000	-	-	-	Amino_oxidase
HKD2_k127_7711668_9	448385.sce1742	0.0001589	49.0	COG0784@1|root,COG4191@1|root,COG0784@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42Q3F@68525|delta/epsilon subdivisions,2WM2F@28221|Deltaproteobacteria,2YUEQ@29|Myxococcales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Reg_prop,Response_reg,Y_Y_Y
HKD2_k127_7711668_2	1156844.KB891842_gene7083	7.405e-112	377.0	COG2730@1|root,COG2730@2|Bacteria,2HW9X@201174|Actinobacteria	201174|Actinobacteria	G	Belongs to the glycosyl hydrolase 5 (cellulase A) family	-	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	CBM_2,Cellulase
HKD2_k127_7711668_5	264462.Bd3148	2.478e-52	200.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,42QEI@68525|delta/epsilon subdivisions,2MSSB@213481|Bdellovibrionales,2WM5N@28221|Deltaproteobacteria	213481|Bdellovibrionales	KLT	Serine Threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PEGA,Pkinase
HKD2_k127_7711668_4	378806.STAUR_5359	2.07e-63	229.0	COG3103@1|root,COG4991@2|Bacteria,1Q2D3@1224|Proteobacteria,437ZE@68525|delta/epsilon subdivisions,2X39E@28221|Deltaproteobacteria,2YUY4@29|Myxococcales	28221|Deltaproteobacteria	T	Bacterial SH3 domain homologues	-	-	-	-	-	-	-	-	-	-	-	-	SH3_3
HKD2_k127_7711668_3	1192034.CAP_3075	3.099e-65	237.0	COG3391@1|root,COG3391@2|Bacteria,1Q2CJ@1224|Proteobacteria,437YW@68525|delta/epsilon subdivisions,2X38S@28221|Deltaproteobacteria,2YUV4@29|Myxococcales	28221|Deltaproteobacteria	S	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7711668_0	448385.sce9167	2.204e-189	607.0	COG0001@1|root,COG0001@2|Bacteria,1MUY5@1224|Proteobacteria,42MBF@68525|delta/epsilon subdivisions,2WJQ2@28221|Deltaproteobacteria,2YU3Q@29|Myxococcales	28221|Deltaproteobacteria	H	Aminotransferase	hemL	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
HKD2_k127_7711668_6	591158.SSMG_07355	1.197e-28	124.0	COG3315@1|root,COG3315@2|Bacteria,2GM4W@201174|Actinobacteria	201174|Actinobacteria	Q	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	LCM,NUDIX
HKD2_k127_7711668_1	448385.sce8066	5.734e-116	403.0	COG2885@1|root,COG2885@2|Bacteria,1R7WJ@1224|Proteobacteria,42QJK@68525|delta/epsilon subdivisions,2WJX0@28221|Deltaproteobacteria,2Z2YX@29|Myxococcales	28221|Deltaproteobacteria	M	Belongs to the ompA family	-	-	-	-	-	-	-	-	-	-	-	-	OmpA,TSP_3
HKD2_k127_7711668_7	215803.DB30_0358	2.289e-06	61.0	COG0823@1|root,COG1520@1|root,COG3055@1|root,COG0823@2|Bacteria,COG1520@2|Bacteria,COG3055@2|Bacteria	2|Bacteria	G	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses	-	-	-	-	-	-	-	-	-	-	-	-	He_PIG,Ig_3,PD40,PKD,Peptidase_S8
HKD2_k127_7712526_2	1254432.SCE1572_08735	1.183e-77	282.0	COG2357@1|root,COG2357@2|Bacteria,1QYWE@1224|Proteobacteria,432GG@68525|delta/epsilon subdivisions,2WY52@28221|Deltaproteobacteria,2Z0Y8@29|Myxococcales	28221|Deltaproteobacteria	S	RelA SpoT domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7712526_4	694440.JOMF01000006_gene457	0.0003092	53.0	arCOG03264@1|root,arCOG03264@2157|Archaea	694440.JOMF01000006_gene457|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7712526_1	448385.sce8078	7.028e-78	274.0	COG1408@1|root,COG1408@2|Bacteria,1MUH5@1224|Proteobacteria,42SS8@68525|delta/epsilon subdivisions,2WPMH@28221|Deltaproteobacteria,2YTWA@29|Myxococcales	28221|Deltaproteobacteria	S	Calcineurin-like phosphoesterase	-	-	-	ko:K07098	-	-	-	-	ko00000	-	-	-	Metallophos
HKD2_k127_7712526_0	1122223.KB890688_gene1825	1.288e-115	382.0	COG2189@1|root,COG2189@2|Bacteria,1WN0J@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	L	DNA methylase	-	-	2.1.1.72	ko:K00571	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
HKD2_k127_7712526_3	378806.STAUR_5417	6.647e-42	156.0	COG2409@1|root,COG2409@2|Bacteria,1R9Z8@1224|Proteobacteria	1224|Proteobacteria	S	MMPL family	ydfJ	-	-	ko:K06994	-	-	-	-	ko00000	-	-	-	MMPL
HKD2_k127_7719771_1	1297742.A176_06439	1.489e-62	240.0	COG3387@1|root,COG3387@2|Bacteria	2|Bacteria	G	glucan 1,4-alpha-glucosidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Bac_rhamnosid6H,Bac_rhamnosid_C,Bac_rhamnosid_N,F5_F8_type_C,Glyco_hydro_15
HKD2_k127_7719771_0	1192034.CAP_8920	3.119e-67	254.0	COG0366@1|root,COG0366@2|Bacteria,1MU90@1224|Proteobacteria,433YZ@68525|delta/epsilon subdivisions,2X44J@28221|Deltaproteobacteria,2YTX3@29|Myxococcales	28221|Deltaproteobacteria	G	Belongs to the glycosyl hydrolase 13 family	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase
HKD2_k127_7721953_6	1192034.CAP_2603	1.869e-109	360.0	COG1606@1|root,COG1606@2|Bacteria,1R7UZ@1224|Proteobacteria,42Q6V@68525|delta/epsilon subdivisions,2WKIM@28221|Deltaproteobacteria,2YUUD@29|Myxococcales	28221|Deltaproteobacteria	S	PFAM asparagine synthase	-	-	-	ko:K06864	-	-	-	-	ko00000	-	-	-	Asn_synthase,NAD_synthase,QueC
HKD2_k127_7721953_7	1192034.CAP_7277	2.373e-103	346.0	COG3239@1|root,COG3239@2|Bacteria,1MY4I@1224|Proteobacteria,42QFN@68525|delta/epsilon subdivisions,2WKUY@28221|Deltaproteobacteria,2YWD0@29|Myxococcales	28221|Deltaproteobacteria	I	Fatty acid desaturase	-	-	1.14.19.23,1.14.19.45	ko:K10255	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000,ko01004	-	-	-	FA_desaturase
HKD2_k127_7721953_18	215803.DB30_3163	3.677e-14	84.0	COG0810@1|root,COG1716@1|root,COG0810@2|Bacteria,COG1716@2|Bacteria,1NEW5@1224|Proteobacteria,42VUF@68525|delta/epsilon subdivisions,2WRV9@28221|Deltaproteobacteria,2YV34@29|Myxococcales	28221|Deltaproteobacteria	T	FHA domain	-	-	-	-	-	-	-	-	-	-	-	-	FHA,TonB_C,Yop-YscD_cpl
HKD2_k127_7721953_0	1192034.CAP_7840	0.0	1088.0	COG0587@1|root,COG0587@2|Bacteria,1MUE4@1224|Proteobacteria,42MYQ@68525|delta/epsilon subdivisions,2WJM2@28221|Deltaproteobacteria,2YTST@29|Myxococcales	28221|Deltaproteobacteria	L	DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase	dnaE2	GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496	2.7.7.7	ko:K02337,ko:K14162	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
HKD2_k127_7721953_4	1192034.CAP_2756	4.641e-159	539.0	COG0277@1|root,COG0277@2|Bacteria,1MXTV@1224|Proteobacteria,42RXR@68525|delta/epsilon subdivisions,2WNHV@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM FAD linked oxidase domain protein	-	-	2.5.1.26	ko:K00803	ko00565,ko01100,ko04146,map00565,map01100,map04146	-	R04311	RC00020,RC02886	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
HKD2_k127_7721953_8	1254432.SCE1572_34730	4.033e-97	350.0	COG0644@1|root,COG0644@2|Bacteria	2|Bacteria	C	geranylgeranyl reductase activity	-	-	-	-	-	-	-	-	-	-	-	-	DAO,FAD_binding_2,FAD_binding_3,FAD_oxidored,HI0933_like,Lycopene_cycl
HKD2_k127_7721953_5	1192034.CAP_4835	7.109e-111	380.0	COG0515@1|root,COG0515@2|Bacteria,1Q1TR@1224|Proteobacteria,437GP@68525|delta/epsilon subdivisions,2X2PH@28221|Deltaproteobacteria,2YX5V@29|Myxococcales	28221|Deltaproteobacteria	KLT	Protein kinase domain	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
HKD2_k127_7721953_2	1035308.AQYY01000002_gene233	2.779e-202	644.0	COG1414@1|root,COG1414@2|Bacteria	2|Bacteria	K	Transcriptional regulator	-	-	3.6.4.12	ko:K03655,ko:K10439,ko:K11708	ko02010,ko02030,ko03440,map02010,map02030,map03440	M00212,M00319	-	-	ko00000,ko00001,ko00002,ko01000,ko02000,ko03400	3.A.1.15,3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	AlbA_2,HATPase_c_4,HTH_IclR,IclR,Peripla_BP_4,VCBS
HKD2_k127_7721953_11	391625.PPSIR1_17070	8.666e-70	248.0	COG1597@1|root,COG1597@2|Bacteria	2|Bacteria	I	lipid kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	DAGK_cat
HKD2_k127_7721953_9	627192.SLG_35310	2.246e-71	248.0	COG4912@1|root,COG4912@2|Bacteria	2|Bacteria	L	Dna alkylation repair	alkD	-	-	-	-	-	-	-	-	-	-	-	DNA_alkylation
HKD2_k127_7721953_1	404589.Anae109_0719	1.459e-219	725.0	COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,42MN9@68525|delta/epsilon subdivisions,2WJZF@28221|Deltaproteobacteria,2YU45@29|Myxococcales	28221|Deltaproteobacteria	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
HKD2_k127_7721953_17	448385.sce1745	3.183e-18	87.0	COG2331@1|root,COG2331@2|Bacteria,1N6Q9@1224|Proteobacteria,42V24@68525|delta/epsilon subdivisions,2WR87@28221|Deltaproteobacteria,2YW0Y@29|Myxococcales	28221|Deltaproteobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	Zn-ribbon_8
HKD2_k127_7721953_10	1192034.CAP_7846	9.097e-71	257.0	COG0077@1|root,COG1605@1|root,COG0077@2|Bacteria,COG1605@2|Bacteria,1MU60@1224|Proteobacteria,42MGN@68525|delta/epsilon subdivisions,2WJET@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Prephenate dehydratase	pheA	-	4.2.1.51,5.4.99.5	ko:K14170	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024,M00025	R00691,R01373,R01715	RC00360,RC03116	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,CM_2,PDT
HKD2_k127_7721953_3	1192034.CAP_7593	8.489e-164	530.0	COG0128@1|root,COG0128@2|Bacteria,1MWMK@1224|Proteobacteria,42N01@68525|delta/epsilon subdivisions,2WKJQ@28221|Deltaproteobacteria,2YUM6@29|Myxococcales	28221|Deltaproteobacteria	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	GO:0003674,GO:0003824,GO:0003866,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046417,GO:0071704,GO:1901576	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	EPSP_synthase
HKD2_k127_7721953_16	391625.PPSIR1_34113	1.663e-33	139.0	COG2200@1|root,COG2204@1|root,COG2200@2|Bacteria,COG2204@2|Bacteria,1MVJY@1224|Proteobacteria,42S4U@68525|delta/epsilon subdivisions,2WTJ9@28221|Deltaproteobacteria,2Z1P1@29|Myxococcales	28221|Deltaproteobacteria	T	EAL domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL
HKD2_k127_7721953_12	448385.sce6877	2.58e-62	221.0	COG0283@1|root,COG0283@2|Bacteria,1MUUD@1224|Proteobacteria,42S4S@68525|delta/epsilon subdivisions,2WNIV@28221|Deltaproteobacteria,2YV25@29|Myxococcales	28221|Deltaproteobacteria	F	Belongs to the cytidylate kinase family. Type 1 subfamily	cmk	GO:0003674,GO:0003824,GO:0004127,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006573,GO:0006575,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0034654,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046939,GO:0046940,GO:0050145,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	2.7.4.25	ko:K00945	ko00240,ko01100,map00240,map01100	M00052	R00158,R00512,R01665	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytidylate_kin
HKD2_k127_7721953_20	518766.Rmar_1811	2.16e-10	72.0	2C8H5@1|root,336VW@2|Bacteria,4NVF0@976|Bacteroidetes,1FJJC@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	C	High potential iron-sulfur protein	-	-	-	-	-	-	-	-	-	-	-	-	HIPIP
HKD2_k127_7721953_14	1384054.N790_05755	1.898e-50	190.0	COG2010@1|root,COG2010@2|Bacteria,1MXXQ@1224|Proteobacteria,1SPE3@1236|Gammaproteobacteria,1X6TH@135614|Xanthomonadales	135614|Xanthomonadales	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,Cytochrome_CBB3
HKD2_k127_7721953_13	1254432.SCE1572_40490	5.351e-56	199.0	COG0539@1|root,COG2183@1|root,COG0539@2|Bacteria,COG2183@2|Bacteria,1MVAV@1224|Proteobacteria,42M29@68525|delta/epsilon subdivisions,2WJ0X@28221|Deltaproteobacteria,2YU9B@29|Myxococcales	28221|Deltaproteobacteria	J	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence	rpsA	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
HKD2_k127_7729493_3	1120948.KB903217_gene845	4.648e-66	230.0	COG3239@1|root,COG3239@2|Bacteria,2GJKF@201174|Actinobacteria,4E0Y5@85010|Pseudonocardiales	201174|Actinobacteria	I	Fatty acid desaturase	desA3	GO:0001676,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016020,GO:0016053,GO:0016213,GO:0016215,GO:0016491,GO:0016705,GO:0016717,GO:0019752,GO:0032787,GO:0042759,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:0071944,GO:0072330,GO:1901576	1.14.19.3	ko:K00508	ko00591,ko01100,map00591,map01100	-	R07063	RC00917	ko00000,ko00001,ko01000,ko01004	-	-	-	FA_desaturase
HKD2_k127_7729493_1	1318628.MARLIPOL_14430	1.946e-92	314.0	COG1018@1|root,COG1018@2|Bacteria,1MY2Q@1224|Proteobacteria,1S01V@1236|Gammaproteobacteria,46CX3@72275|Alteromonadaceae	1236|Gammaproteobacteria	C	COG1018 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_6,Fer2,NAD_binding_1
HKD2_k127_7729493_0	163908.KB235896_gene663	1.003e-150	499.0	COG4097@1|root,COG5126@1|root,COG4097@2|Bacteria,COG5126@2|Bacteria,1G2G1@1117|Cyanobacteria,1HKUB@1161|Nostocales	1117|Cyanobacteria	P	FAD-binding domain	-	-	1.18.1.3	ko:K00529	ko00071,ko00360,ko01120,ko01220,map00071,map00360,map01120,map01220	M00545	R02000,R06782,R06783	RC00098	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	EF-hand_7,EF-hand_8,FAD_binding_8,Ferric_reduct,NAD_binding_1,NAD_binding_6
HKD2_k127_7729493_7	880073.Calab_3333	1.587e-14	82.0	COG0484@1|root,COG0484@2|Bacteria	2|Bacteria	O	heat shock protein binding	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7729493_2	448385.sce6507	1.164e-72	274.0	COG0457@1|root,COG0457@2|Bacteria,1MXK4@1224|Proteobacteria,42PK9@68525|delta/epsilon subdivisions,2WM9F@28221|Deltaproteobacteria,2YVH9@29|Myxococcales	28221|Deltaproteobacteria	S	Oxygen tolerance	-	-	-	-	-	-	-	-	-	-	-	-	BatD
HKD2_k127_7729493_4	1192034.CAP_4448	2.532e-55	202.0	COG0457@1|root,COG0457@2|Bacteria,1PYTB@1224|Proteobacteria,42VYS@68525|delta/epsilon subdivisions,2XA0E@28221|Deltaproteobacteria,2YW26@29|Myxococcales	28221|Deltaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_2
HKD2_k127_772974_1	1242864.D187_001133	3.643e-93	317.0	COG3268@1|root,COG3268@2|Bacteria,1MVI3@1224|Proteobacteria,431ET@68525|delta/epsilon subdivisions,2WWV2@28221|Deltaproteobacteria,2YX5R@29|Myxococcales	28221|Deltaproteobacteria	S	Saccharopine dehydrogenase NADP binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Sacchrp_dh_NADP
HKD2_k127_772974_0	391625.PPSIR1_34792	1.006e-125	430.0	COG0318@1|root,COG3243@1|root,COG0318@2|Bacteria,COG3243@2|Bacteria,1MWSD@1224|Proteobacteria,42Q72@68525|delta/epsilon subdivisions,2WM9N@28221|Deltaproteobacteria	28221|Deltaproteobacteria	IQ	PFAM AMP-dependent synthetase and ligase	-	-	6.2.1.48	ko:K02182	-	-	-	-	ko00000,ko01000	-	-	-	AMP-binding,AMP-binding_C
HKD2_k127_7735776_1	1254432.SCE1572_15440	1.341e-166	538.0	COG0260@1|root,COG0260@2|Bacteria,1MUF9@1224|Proteobacteria,42M2G@68525|delta/epsilon subdivisions,2WJ80@28221|Deltaproteobacteria,2YUN7@29|Myxococcales	28221|Deltaproteobacteria	E	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	pepA	-	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17,Peptidase_M17_N
HKD2_k127_7735776_2	240292.Ava_4156	5.293e-77	270.0	COG0031@1|root,COG3620@1|root,COG0031@2|Bacteria,COG3620@2|Bacteria,1G0T4@1117|Cyanobacteria,1HM63@1161|Nostocales	1117|Cyanobacteria	EK	Pyridoxal-phosphate dependent enzyme	-	-	4.2.1.22	ko:K01697	ko00260,ko00270,ko01100,ko01130,ko01230,map00260,map00270,map01100,map01130,map01230	M00035,M00338	R00891,R01290,R04942	RC00056,RC00069,RC00256,RC00489,RC01246	ko00000,ko00001,ko00002,ko01000	-	-	-	CBS,PALP
HKD2_k127_7735776_3	1254432.SCE1572_45845	4.155e-75	259.0	2ETUP@1|root,33MBY@2|Bacteria,1NG8K@1224|Proteobacteria,42XR1@68525|delta/epsilon subdivisions,2WSS8@28221|Deltaproteobacteria,2YW5Y@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7735776_5	309799.DICTH_0179	3.624e-24	116.0	COG1520@1|root,COG1520@2|Bacteria	2|Bacteria	S	amino acid activation for nonribosomal peptide biosynthetic process	-	-	-	ko:K20952	ko05111,map05111	-	-	-	ko00000,ko00001	-	-	-	Beta-prism_lec,PQQ_2,PQQ_3,Pkinase,VCBS
HKD2_k127_7735776_0	1254432.SCE1572_45840	2.093e-241	764.0	COG1674@1|root,COG1674@2|Bacteria,1MVPI@1224|Proteobacteria,42N4X@68525|delta/epsilon subdivisions,2WIPR@28221|Deltaproteobacteria,2YU2E@29|Myxococcales	28221|Deltaproteobacteria	D	Belongs to the FtsK SpoIIIE SftA family	ftsK	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
HKD2_k127_7737819_6	292459.STH1269	2.058e-44	185.0	COG2141@1|root,COG2141@2|Bacteria,1TPRS@1239|Firmicutes,25BCC@186801|Clostridia	186801|Clostridia	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
HKD2_k127_7737819_1	314278.NB231_16468	2.601e-263	828.0	COG1523@1|root,COG1523@2|Bacteria,1MU19@1224|Proteobacteria,1RP6F@1236|Gammaproteobacteria,1WX62@135613|Chromatiales	135613|Chromatiales	G	Belongs to the glycosyl hydrolase 13 family	-	-	3.2.1.68	ko:K01214	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
HKD2_k127_7737819_9	986075.CathTA2_0458	3.37e-16	83.0	COG0745@1|root,COG0745@2|Bacteria,1TTB8@1239|Firmicutes,4HAJK@91061|Bacilli	91061|Bacilli	T	Transcriptional regulator	-	-	-	ko:K07775	ko02020,map02020	M00458	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
HKD2_k127_7737819_11	351607.Acel_1871	1.839e-08	62.0	COG0835@1|root,COG0835@2|Bacteria,2GZIB@201174|Actinobacteria	201174|Actinobacteria	NT	CheW-like domain	-	-	-	ko:K03408	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheW
HKD2_k127_7737819_7	404589.Anae109_0466	1.468e-38	159.0	COG1352@1|root,COG1352@2|Bacteria,1MVP3@1224|Proteobacteria	1224|Proteobacteria	NT	Methyl-transferase	cheR	-	2.1.1.80	ko:K00575	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko01000,ko02035	-	-	-	CheR,CheR_N
HKD2_k127_7737819_10	1304874.JAFY01000002_gene33	3.721e-09	66.0	COG0835@1|root,COG0835@2|Bacteria,3TBN6@508458|Synergistetes	508458|Synergistetes	NT	Two component signalling adaptor domain	-	-	-	ko:K03408	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheW
HKD2_k127_7737819_4	1192034.CAP_4268	3.091e-66	244.0	COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,42N1S@68525|delta/epsilon subdivisions,2WK7R@28221|Deltaproteobacteria,2YUUY@29|Myxococcales	28221|Deltaproteobacteria	NT	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer).	mcp40H-21	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	4HB_MCP_1,CHASE3,HAMP,MCPsignal,dCache_1
HKD2_k127_7737819_3	326427.Cagg_2405	1.532e-100	354.0	COG0643@1|root,COG0745@1|root,COG2198@1|root,COG0643@2|Bacteria,COG0745@2|Bacteria,COG2198@2|Bacteria,2G6G3@200795|Chloroflexi,374SA@32061|Chloroflexia	32061|Chloroflexia	T	ATP-binding region, ATPase domain protein	-	-	2.7.13.3	ko:K03407	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg
HKD2_k127_7737819_8	426117.M446_0245	2.767e-32	145.0	COG2201@1|root,COG2201@2|Bacteria,1MWCN@1224|Proteobacteria,2TSGV@28211|Alphaproteobacteria,1JT90@119045|Methylobacteriaceae	28211|Alphaproteobacteria	NT	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR	cheB	-	3.1.1.61,3.5.1.44	ko:K03412	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest,Response_reg
HKD2_k127_7737819_5	1192034.CAP_6262	2.237e-62	242.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,42RC9@68525|delta/epsilon subdivisions,2WN5U@28221|Deltaproteobacteria,2YWJ8@29|Myxococcales	28221|Deltaproteobacteria	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HKD2_k127_7737819_0	1254432.SCE1572_11780	2.717e-274	890.0	COG0457@1|root,COG0515@1|root,COG3899@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG3899@2|Bacteria,1QA6R@1224|Proteobacteria,438FC@68525|delta/epsilon subdivisions,2X3QC@28221|Deltaproteobacteria,2YWU9@29|Myxococcales	28221|Deltaproteobacteria	KLT	Family membership	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,Pkinase
HKD2_k127_7737819_2	1254432.SCE1572_44485	1.508e-147	484.0	COG2366@1|root,COG2366@2|Bacteria,1MVMH@1224|Proteobacteria,42M9A@68525|delta/epsilon subdivisions,2WJ3Y@28221|Deltaproteobacteria,2YUEP@29|Myxococcales	28221|Deltaproteobacteria	S	Penicillin amidase	-	-	3.5.1.11	ko:K01434	ko00311,ko01130,map00311,map01130	-	R02170	RC00166,RC00328	ko00000,ko00001,ko01000,ko01002	-	-	-	Penicil_amidase
HKD2_k127_7739470_13	448385.sce4052	5.712e-09	57.0	COG2801@1|root,COG2801@2|Bacteria,1N207@1224|Proteobacteria,42Z4V@68525|delta/epsilon subdivisions,2WU31@28221|Deltaproteobacteria,2Z2U7@29|Myxococcales	28221|Deltaproteobacteria	L	High confidence in function and specificity	-	-	-	-	-	-	-	-	-	-	-	-	HTH_32,rve,rve_3
HKD2_k127_7739470_1	1254432.SCE1572_46030	7.517e-125	407.0	COG0451@1|root,COG0451@2|Bacteria,1MW32@1224|Proteobacteria,42NJT@68525|delta/epsilon subdivisions,2WM7E@28221|Deltaproteobacteria,2YXN2@29|Myxococcales	28221|Deltaproteobacteria	GM	epimerase dehydratase	dfrA	-	1.1.1.219	ko:K00091	-	-	-	-	ko00000,ko01000	-	-	-	3Beta_HSD,Epimerase
HKD2_k127_7739470_4	1192034.CAP_2158	1.108e-90	310.0	COG1597@1|root,COG1597@2|Bacteria,1RCJT@1224|Proteobacteria,42W6W@68525|delta/epsilon subdivisions,2X6V3@28221|Deltaproteobacteria,2YUYD@29|Myxococcales	28221|Deltaproteobacteria	I	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase	-	-	-	-	-	-	-	-	-	-	-	-	DAGK_cat
HKD2_k127_7739470_0	1254432.SCE1572_04245	2.63e-168	559.0	COG0642@1|root,COG0784@1|root,COG5000@1|root,COG5002@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,COG5000@2|Bacteria,COG5002@2|Bacteria,1NRP8@1224|Proteobacteria,439XQ@68525|delta/epsilon subdivisions,2X1V0@28221|Deltaproteobacteria,2YZ8J@29|Myxococcales	28221|Deltaproteobacteria	T	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HATPase_c,HisKA,PAS_4,Response_reg
HKD2_k127_7739470_2	1254432.SCE1572_46275	1.305e-119	410.0	COG1893@1|root,COG1893@2|Bacteria,1P0AW@1224|Proteobacteria,42PK4@68525|delta/epsilon subdivisions,2WM1G@28221|Deltaproteobacteria,2YUAW@29|Myxococcales	28221|Deltaproteobacteria	H	Ketopantoate reductase PanE/ApbA C terminal	-	-	1.1.1.169	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R02472	RC00726	ko00000,ko00001,ko00002,ko01000	-	-	-	ApbA,ApbA_C
HKD2_k127_7739470_12	1192034.CAP_8713	4.298e-09	69.0	2DBMC@1|root,2Z9YC@2|Bacteria,1PY40@1224|Proteobacteria,43E0Z@68525|delta/epsilon subdivisions,2WZDV@28221|Deltaproteobacteria,2Z1X8@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7739470_3	448385.sce3098	8.405e-99	336.0	COG0707@1|root,COG0707@2|Bacteria,1MWQP@1224|Proteobacteria,42R9T@68525|delta/epsilon subdivisions,2WMWQ@28221|Deltaproteobacteria,2YTYH@29|Myxococcales	28221|Deltaproteobacteria	M	Glycosyl transferase family 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_3
HKD2_k127_7739470_9	1254432.SCE1572_07835	8.23e-18	91.0	COG2204@1|root,COG2204@2|Bacteria,1NABF@1224|Proteobacteria,43C0I@68525|delta/epsilon subdivisions,2X7B5@28221|Deltaproteobacteria,2YVMV@29|Myxococcales	28221|Deltaproteobacteria	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
HKD2_k127_7739470_8	1192034.CAP_2618	5.154e-18	92.0	2AEYE@1|root,314WB@2|Bacteria,1PUU5@1224|Proteobacteria,434MW@68525|delta/epsilon subdivisions,2WYZA@28221|Deltaproteobacteria,2Z0ZG@29|Myxococcales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF4398)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4398
HKD2_k127_7739470_6	1192034.CAP_2619	9.277e-52	199.0	COG2885@1|root,COG2885@2|Bacteria,1R8DG@1224|Proteobacteria,42NGC@68525|delta/epsilon subdivisions,2WX5K@28221|Deltaproteobacteria,2YXCP@29|Myxococcales	28221|Deltaproteobacteria	M	Domain of unknown function (DUF4398)	ompA2	-	-	-	-	-	-	-	-	-	-	-	DUF4398,OmpA
HKD2_k127_7739470_5	278963.ATWD01000001_gene3281	4.902e-59	207.0	COG0526@1|root,COG0526@2|Bacteria,3Y5H5@57723|Acidobacteria,2JMSM@204432|Acidobacteriia	204432|Acidobacteriia	CO	Thioredoxin	-	-	1.8.1.8	ko:K03672	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Thioredoxin
HKD2_k127_7739470_10	1379281.AVAG01000018_gene1023	2.507e-13	76.0	COG0517@1|root,COG0517@2|Bacteria,1RA25@1224|Proteobacteria,42R80@68525|delta/epsilon subdivisions,2WMW6@28221|Deltaproteobacteria,2MARF@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	PFAM CBS domain containing protein	-	-	-	ko:K04767	-	-	-	-	ko00000	-	-	-	CBS
HKD2_k127_7739470_7	1192034.CAP_3363	8.667e-35	133.0	COG0499@1|root,COG0499@2|Bacteria,1MUQ2@1224|Proteobacteria,42M83@68525|delta/epsilon subdivisions,2WIZE@28221|Deltaproteobacteria,2YU8Q@29|Myxococcales	28221|Deltaproteobacteria	H	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine	ahcY	GO:0000096,GO:0003674,GO:0003824,GO:0004013,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009069,GO:0009116,GO:0009119,GO:0009987,GO:0016787,GO:0016801,GO:0016802,GO:0017144,GO:0019752,GO:0033353,GO:0034641,GO:0042278,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901605,GO:1901657	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
HKD2_k127_7763170_4	1192034.CAP_1991	5.591e-37	155.0	COG0265@1|root,COG1005@1|root,COG0265@2|Bacteria,COG1005@2|Bacteria,1MU2R@1224|Proteobacteria,42MMX@68525|delta/epsilon subdivisions,2WIX8@28221|Deltaproteobacteria,2YYND@29|Myxococcales	28221|Deltaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	nuoH	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh,PDZ_2
HKD2_k127_7763170_0	1192034.CAP_2407	1.989e-118	390.0	COG0836@1|root,COG0836@2|Bacteria,1MV39@1224|Proteobacteria,42MDP@68525|delta/epsilon subdivisions,2WJEN@28221|Deltaproteobacteria,2YUTZ@29|Myxococcales	28221|Deltaproteobacteria	M	Mannose-6-phosphate isomerase	manAC	-	2.7.7.13	ko:K00971	ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110	M00114,M00361,M00362	R00885	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	MannoseP_isomer,NTP_transferase
HKD2_k127_7763170_1	448385.sce2027	9.122e-79	272.0	COG1354@1|root,COG1354@2|Bacteria,1MVCN@1224|Proteobacteria,42RG5@68525|delta/epsilon subdivisions,2WNRE@28221|Deltaproteobacteria,2YV06@29|Myxococcales	28221|Deltaproteobacteria	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves	scpA	-	-	ko:K05896	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpA
HKD2_k127_7763170_2	1254432.SCE1572_12385	1.955e-71	250.0	COG1386@1|root,COG5164@1|root,COG1386@2|Bacteria,COG5164@2|Bacteria,1PUA6@1224|Proteobacteria,42SVD@68525|delta/epsilon subdivisions,2WPFX@28221|Deltaproteobacteria,2Z049@29|Myxococcales	28221|Deltaproteobacteria	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves	scpB	-	-	ko:K06024	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpB
HKD2_k127_7763494_0	448385.sce5114	1.126e-189	609.0	COG1206@1|root,COG1206@2|Bacteria,1MWNQ@1224|Proteobacteria,42MTS@68525|delta/epsilon subdivisions,2WJ50@28221|Deltaproteobacteria,2YU50@29|Myxococcales	28221|Deltaproteobacteria	J	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs	trmFO	GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363	2.1.1.74	ko:K04094	-	-	-	-	ko00000,ko01000,ko03016,ko03036	-	-	-	GIDA
HKD2_k127_7763494_2	1150626.PHAMO_230109	2.586e-39	155.0	COG1396@1|root,COG1396@2|Bacteria,1RE8Z@1224|Proteobacteria,2TXJM@28211|Alphaproteobacteria,2JTNG@204441|Rhodospirillales	204441|Rhodospirillales	K	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2,HTH_3
HKD2_k127_7763494_1	1192034.CAP_2415	8.752e-94	314.0	COG2189@1|root,COG2189@2|Bacteria,1MX9M@1224|Proteobacteria,42RUT@68525|delta/epsilon subdivisions,2X9ZW@28221|Deltaproteobacteria,2Z1HJ@29|Myxococcales	28221|Deltaproteobacteria	L	Belongs to the N(4) N(6)-methyltransferase family	-	-	2.1.1.72	ko:K00571	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
HKD2_k127_7764241_0	1192034.CAP_5038	1.082e-152	494.0	COG4591@1|root,COG4591@2|Bacteria,1MVV7@1224|Proteobacteria,42MV0@68525|delta/epsilon subdivisions,2WITK@28221|Deltaproteobacteria,2YUSA@29|Myxococcales	28221|Deltaproteobacteria	M	ABC-type transport system involved in lipoprotein release permease component	lolC	-	-	ko:K09808	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.125	-	-	FtsX,MacB_PCD
HKD2_k127_7764241_1	1192034.CAP_5223	1.309e-31	144.0	COG2203@1|root,COG2203@2|Bacteria	2|Bacteria	T	Gaf domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GAF,GAF_2,GGDEF,HATPase_c,HisKA,Hpt,PAS,Response_reg
HKD2_k127_7769389_3	1192034.CAP_0942	1.129e-32	132.0	COG1073@1|root,COG1073@2|Bacteria,1QRTY@1224|Proteobacteria,433U7@68525|delta/epsilon subdivisions,2X3GS@28221|Deltaproteobacteria,2YW15@29|Myxococcales	28221|Deltaproteobacteria	S	alpha beta	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7769389_4	1408473.JHXO01000009_gene3325	3.858e-16	86.0	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	-	-	-	ko:K03828	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_1,Acetyltransf_10
HKD2_k127_7769389_1	521674.Plim_4242	5.592e-220	698.0	COG0043@1|root,COG0043@2|Bacteria,2IYCA@203682|Planctomycetes	203682|Planctomycetes	H	COG0043 3-polyprenyl-4-hydroxybenzoate decarboxylase and	-	-	4.1.1.98	ko:K03182	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04985,R04986	RC00391	ko00000,ko00001,ko00002,ko01000	-	-	-	UbiD
HKD2_k127_7769389_2	1448860.BBJO01000005_gene2360	5.466e-50	193.0	COG0189@1|root,arCOG01589@2157|Archaea,2XXK5@28890|Euryarchaeota,23VQP@183963|Halobacteria	183963|Halobacteria	H	COG0189 Glutathione synthase Ribosomal protein S6 modification enzyme (glutaminyl transferase)	-	-	-	-	-	-	-	-	-	-	-	-	GSH-S_ATP
HKD2_k127_7769389_0	9541.XP_005576240.1	4.206e-277	894.0	COG4631@1|root,KOG0430@2759|Eukaryota,38GEI@33154|Opisthokonta,3BC8Q@33208|Metazoa,3CXMB@33213|Bilateria,4842N@7711|Chordata,48ZCW@7742|Vertebrata,3J9KI@40674|Mammalia,35DX0@314146|Euarchontoglires,4MD5R@9443|Primates,35YHT@314294|Cercopithecoidea	33208|Metazoa	F	Xanthine dehydrogenase	XDH	GO:0000166,GO:0000302,GO:0001932,GO:0001933,GO:0001934,GO:0001936,GO:0001937,GO:0002197,GO:0002237,GO:0003674,GO:0003824,GO:0004031,GO:0004854,GO:0004855,GO:0005488,GO:0005506,GO:0005515,GO:0005575,GO:0005576,GO:0005615,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0005783,GO:0005829,GO:0006082,GO:0006139,GO:0006144,GO:0006145,GO:0006150,GO:0006163,GO:0006195,GO:0006206,GO:0006520,GO:0006525,GO:0006568,GO:0006576,GO:0006586,GO:0006629,GO:0006644,GO:0006650,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006919,GO:0006950,GO:0006979,GO:0007275,GO:0007568,GO:0007589,GO:0007595,GO:0008150,GO:0008152,GO:0008285,GO:0008340,GO:0009056,GO:0009058,GO:0009064,GO:0009072,GO:0009112,GO:0009114,GO:0009115,GO:0009117,GO:0009166,GO:0009266,GO:0009308,GO:0009408,GO:0009605,GO:0009607,GO:0009617,GO:0009628,GO:0009636,GO:0009892,GO:0009893,GO:0009966,GO:0009967,GO:0009968,GO:0009987,GO:0010033,GO:0010035,GO:0010038,GO:0010044,GO:0010259,GO:0010468,GO:0010562,GO:0010563,GO:0010604,GO:0010605,GO:0010629,GO:0010646,GO:0010647,GO:0010648,GO:0010941,GO:0010942,GO:0010950,GO:0010952,GO:0012505,GO:0016491,GO:0016528,GO:0016529,GO:0016623,GO:0016661,GO:0016662,GO:0016725,GO:0016726,GO:0016727,GO:0016903,GO:0017144,GO:0018130,GO:0019220,GO:0019222,GO:0019438,GO:0019439,GO:0019637,GO:0019752,GO:0022603,GO:0023051,GO:0023056,GO:0023057,GO:0030151,GO:0030162,GO:0030856,GO:0030857,GO:0030879,GO:0031323,GO:0031324,GO:0031325,GO:0031399,GO:0031400,GO:0031401,GO:0032268,GO:0032269,GO:0032270,GO:0032496,GO:0032501,GO:0032502,GO:0032872,GO:0032874,GO:0032991,GO:0033993,GO:0034097,GO:0034404,GO:0034418,GO:0034465,GO:0034612,GO:0034641,GO:0034654,GO:0034655,GO:0036094,GO:0042127,GO:0042221,GO:0042325,GO:0042326,GO:0042327,GO:0042430,GO:0042493,GO:0042542,GO:0042579,GO:0042802,GO:0042803,GO:0042981,GO:0043065,GO:0043067,GO:0043068,GO:0043085,GO:0043167,GO:0043168,GO:0043169,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043280,GO:0043281,GO:0043408,GO:0043410,GO:0043436,GO:0043473,GO:0043546,GO:0044093,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044255,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044421,GO:0044424,GO:0044444,GO:0044464,GO:0045471,GO:0045595,GO:0045596,GO:0045601,GO:0045602,GO:0045862,GO:0045936,GO:0045937,GO:0046100,GO:0046110,GO:0046113,GO:0046415,GO:0046434,GO:0046483,GO:0046486,GO:0046677,GO:0046700,GO:0046872,GO:0046903,GO:0046914,GO:0046983,GO:0048037,GO:0048066,GO:0048069,GO:0048072,GO:0048513,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048583,GO:0048584,GO:0048585,GO:0048731,GO:0048732,GO:0048856,GO:0050250,GO:0050421,GO:0050660,GO:0050662,GO:0050678,GO:0050680,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0050878,GO:0050896,GO:0051093,GO:0051171,GO:0051172,GO:0051173,GO:0051174,GO:0051179,GO:0051234,GO:0051239,GO:0051241,GO:0051246,GO:0051247,GO:0051248,GO:0051336,GO:0051345,GO:0051536,GO:0051537,GO:0051540,GO:0051704,GO:0051707,GO:0051716,GO:0051896,GO:0051898,GO:0052547,GO:0052548,GO:0055086,GO:0055114,GO:0060255,GO:0065007,GO:0065008,GO:0065009,GO:0070302,GO:0070304,GO:0070555,GO:0070674,GO:0070887,GO:0071310,GO:0071345,GO:0071347,GO:0071356,GO:0071704,GO:0071949,GO:0072521,GO:0072522,GO:0072523,GO:0072527,GO:0080090,GO:0080134,GO:0080135,GO:0090287,GO:0090288,GO:0097159,GO:0097184,GO:0097305,GO:0098809,GO:1900744,GO:1900745,GO:1900746,GO:1900747,GO:1901265,GO:1901292,GO:1901342,GO:1901343,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901698,GO:1901700,GO:1902494,GO:1902531,GO:1902532,GO:1902533,GO:1902547,GO:1902548,GO:2000026,GO:2000116,GO:2000181,GO:2000377,GO:2000379,GO:2001056,GO:2001212,GO:2001213	1.17.1.4,1.17.3.2,1.2.3.1	ko:K00106,ko:K00157	ko00230,ko00232,ko00280,ko00350,ko00380,ko00750,ko00760,ko00830,ko00982,ko00983,ko01100,ko01110,ko01120,ko04146,ko04630,map00230,map00232,map00280,map00350,map00380,map00750,map00760,map00830,map00982,map00983,map01100,map01110,map01120,map04146,map04630	M00546	R01709,R01768,R01769,R02103,R02107,R02125,R02657,R03871,R04085,R04904,R07942,R07977,R07978,R07979,R08235,R08349,R08384,R08408	RC00075,RC00080,RC00143,RC00218,RC00242,RC01073,RC01074,RC02017,RC02199	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2,CO_deh_flav_C,FAD_binding_5,Fer2,Fer2_2
HKD2_k127_7772583_0	448385.sce7957	6.942e-91	308.0	COG0092@1|root,COG0092@2|Bacteria,1MUAI@1224|Proteobacteria,42N5W@68525|delta/epsilon subdivisions,2WIU3@28221|Deltaproteobacteria,2YUEX@29|Myxococcales	28221|Deltaproteobacteria	J	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation	rpsC	GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02982	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KH_2,Ribosomal_S3_C
HKD2_k127_7772583_2	1192034.CAP_1819	3.372e-42	157.0	COG0091@1|root,COG0091@2|Bacteria,1RH0W@1224|Proteobacteria,42TRE@68525|delta/epsilon subdivisions,2WQBH@28221|Deltaproteobacteria,2Z1JN@29|Myxococcales	28221|Deltaproteobacteria	J	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome	rplV	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02890	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L22
HKD2_k127_7772583_3	1254432.SCE1572_13970	2.214e-38	156.0	COG4636@1|root,COG4636@2|Bacteria	2|Bacteria	D	protein conserved in cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	Uma2
HKD2_k127_7772583_1	1297742.A176_04088	2.24e-76	278.0	COG3148@1|root,COG3148@2|Bacteria,1MZCN@1224|Proteobacteria,42S7K@68525|delta/epsilon subdivisions,2WQI0@28221|Deltaproteobacteria,2YW7K@29|Myxococcales	28221|Deltaproteobacteria	S	DTW	-	-	-	ko:K05812	-	-	-	-	ko00000	-	-	-	DTW
HKD2_k127_7772583_4	146922.JOFU01000067_gene6628	1.735e-27	122.0	COG3555@1|root,COG3555@2|Bacteria,2ICJH@201174|Actinobacteria	201174|Actinobacteria	O	Aspartyl Asparaginyl beta-hydroxylase	-	-	-	ko:K12979	-	-	-	-	ko00000,ko01000,ko01005	-	-	-	Asp_Arg_Hydrox
HKD2_k127_7773108_1	1278073.MYSTI_07996	8.779e-41	156.0	COG0604@1|root,COG0604@2|Bacteria,1MWBD@1224|Proteobacteria,42PQH@68525|delta/epsilon subdivisions,2WM5W@28221|Deltaproteobacteria,2YWUY@29|Myxococcales	28221|Deltaproteobacteria	C	Zinc-binding dehydrogenase	-	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N,ADH_zinc_N_2
HKD2_k127_7773108_2	1144275.COCOR_07354	3.225e-23	112.0	COG1647@1|root,COG1647@2|Bacteria,1MVZP@1224|Proteobacteria,42NBK@68525|delta/epsilon subdivisions,2WIUP@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	Serine aminopeptidase, S33	-	-	3.1.1.1	ko:K03928	-	-	-	-	ko00000,ko01000	-	-	-	Acyltransferase,Hydrolase_4
HKD2_k127_7773108_0	448385.sce3596	4.825e-63	228.0	COG4105@1|root,COG4105@2|Bacteria,1MVS5@1224|Proteobacteria,42RV8@68525|delta/epsilon subdivisions,2WKU0@28221|Deltaproteobacteria,2YVHZ@29|Myxococcales	28221|Deltaproteobacteria	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamD	-	-	ko:K05807	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	YfiO
HKD2_k127_7773108_3	502025.Hoch_3864	0.0002252	49.0	COG5184@1|root,COG5184@2|Bacteria,1QF75@1224|Proteobacteria,434P4@68525|delta/epsilon subdivisions,2WZ0D@28221|Deltaproteobacteria,2Z125@29|Myxococcales	28221|Deltaproteobacteria	DZ	regulator of chromosome condensation, RCC1	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7775993_2	448385.sce0307	7e-43	161.0	COG0515@1|root,COG2203@1|root,COG2204@1|root,COG2909@1|root,COG0515@2|Bacteria,COG2203@2|Bacteria,COG2204@2|Bacteria,COG2909@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions	1224|Proteobacteria	T	two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HTH_8,Pkinase,Sigma54_activat,TPR_12
HKD2_k127_7775993_9	240292.Ava_3991	0.0001442	51.0	2EJSZ@1|root,33DHM@2|Bacteria	2|Bacteria	S	VHL beta domain	-	-	-	-	-	-	-	-	-	-	-	-	VHL
HKD2_k127_7775993_8	595537.Varpa_5688	8.278e-09	65.0	2F9PX@1|root,34203@2|Bacteria,1NY7H@1224|Proteobacteria,2W3DC@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7775993_1	290397.Adeh_0078	1.261e-52	192.0	2A9VF@1|root,30Z3B@2|Bacteria,1PKZS@1224|Proteobacteria,435JG@68525|delta/epsilon subdivisions,2WZXJ@28221|Deltaproteobacteria,2Z0YG@29|Myxococcales	290397.Adeh_0078|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7775993_3	1458275.AZ34_15630	5.676e-36	145.0	COG1225@1|root,COG1225@2|Bacteria,1RH4P@1224|Proteobacteria,2VT1P@28216|Betaproteobacteria	28216|Betaproteobacteria	O	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	-	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
HKD2_k127_7775993_5	1254432.SCE1572_52700	6.594e-25	110.0	COG0711@1|root,COG0711@2|Bacteria,1Q25M@1224|Proteobacteria,437SR@68525|delta/epsilon subdivisions,2X31U@28221|Deltaproteobacteria,2Z2TD@29|Myxococcales	28221|Deltaproteobacteria	C	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)	-	-	-	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_B
HKD2_k127_7775993_6	1254432.SCE1572_52695	5.643e-19	98.0	COG0711@1|root,COG0711@2|Bacteria,1N97K@1224|Proteobacteria,42VYP@68525|delta/epsilon subdivisions,2WZJJ@28221|Deltaproteobacteria,2Z29S@29|Myxococcales	28221|Deltaproteobacteria	C	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)	-	-	-	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_B
HKD2_k127_7775993_4	690850.Desaf_1581	1.8e-27	128.0	COG0712@1|root,COG0712@2|Bacteria,1MVRH@1224|Proteobacteria,42U68@68525|delta/epsilon subdivisions,2WQJS@28221|Deltaproteobacteria,2MBGB@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpH	-	-	ko:K02113	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	OSCP
HKD2_k127_7775993_0	706587.Desti_3707	9.558e-67	230.0	COG0056@1|root,COG0056@2|Bacteria,1MUG7@1224|Proteobacteria,42MVX@68525|delta/epsilon subdivisions,2WIK7@28221|Deltaproteobacteria,2MRD2@213462|Syntrophobacterales	28221|Deltaproteobacteria	F	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	atpA	-	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
HKD2_k127_7776206_0	1192034.CAP_4725	8.23e-180	588.0	COG0457@1|root,COG0515@1|root,COG5616@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG5616@2|Bacteria,1MV1P@1224|Proteobacteria,42PPB@68525|delta/epsilon subdivisions,2X5YN@28221|Deltaproteobacteria,2YUEJ@29|Myxococcales	28221|Deltaproteobacteria	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_10,TPR_12
HKD2_k127_7776206_1	1192034.CAP_8363	6.276e-57	214.0	COG0515@1|root,COG0515@2|Bacteria,1QA6R@1224|Proteobacteria,439KJ@68525|delta/epsilon subdivisions,2X4XC@28221|Deltaproteobacteria,2Z096@29|Myxococcales	28221|Deltaproteobacteria	KLT	Lipopolysaccharide kinase (Kdo/WaaP) family	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HKD2_k127_7779017_1	215803.DB30_5750	9.711e-129	442.0	COG4258@1|root,COG4258@2|Bacteria,1QX7Z@1224|Proteobacteria,43C13@68525|delta/epsilon subdivisions,2X7BR@28221|Deltaproteobacteria,2YU55@29|Myxococcales	28221|Deltaproteobacteria	S	MMPL family	-	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
HKD2_k127_7779017_4	448385.sce3355	3.859e-19	97.0	COG0331@1|root,COG0331@2|Bacteria,1MV6N@1224|Proteobacteria,42MKH@68525|delta/epsilon subdivisions,2WIWQ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	malonyl CoA-acyl carrier protein transacylase	fabD	-	2.3.1.39	ko:K00645	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	M00082	R01626,R11671	RC00004,RC00039,RC02727	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyl_transf_1
HKD2_k127_7779017_5	45157.CMK096CT	5.702e-08	64.0	2CYAE@1|root,2S367@2759|Eukaryota	2759|Eukaryota	S	Endonuclease/Exonuclease/phosphatase family	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
HKD2_k127_7779017_0	1254432.SCE1572_04195	1.393e-210	683.0	COG1233@1|root,COG1233@2|Bacteria,1MV2R@1224|Proteobacteria,42NXM@68525|delta/epsilon subdivisions,2WQMZ@28221|Deltaproteobacteria,2YY10@29|Myxococcales	28221|Deltaproteobacteria	C	Flavin containing amine oxidoreductase	-	-	1.3.99.23	ko:K09516	ko00830,map00830	-	R07163	RC01835	ko00000,ko00001,ko01000	-	-	-	Amino_oxidase
HKD2_k127_7779017_3	1173022.Cri9333_1145	1.123e-20	106.0	COG4191@1|root,COG4251@1|root,COG4191@2|Bacteria,COG4251@2|Bacteria,1G0A1@1117|Cyanobacteria,1H7JR@1150|Oscillatoriales	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE3,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9
HKD2_k127_7779017_2	1242864.D187_008946	4.743e-58	221.0	COG0642@1|root,COG2205@2|Bacteria,1MXH7@1224|Proteobacteria,43AYG@68525|delta/epsilon subdivisions	1224|Proteobacteria	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	2.7.13.3	ko:K07636	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
HKD2_k127_7780580_4	448385.sce0841	1.651e-18	85.0	COG0050@1|root,COG0050@2|Bacteria,1MVC0@1224|Proteobacteria,42MWZ@68525|delta/epsilon subdivisions,2WJ2B@28221|Deltaproteobacteria,2YX6I@29|Myxococcales	28221|Deltaproteobacteria	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
HKD2_k127_7780580_5	1042376.AFPK01000068_gene476	1.793e-07	57.0	2EHBZ@1|root,33B3U@2|Bacteria,4NZK3@976|Bacteroidetes,1I71Q@117743|Flavobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7780580_1	448385.sce0830	2.79e-65	239.0	COG1729@1|root,COG1729@2|Bacteria,1R0BI@1224|Proteobacteria,43CTU@68525|delta/epsilon subdivisions,2X81F@28221|Deltaproteobacteria,2Z3J8@29|Myxococcales	28221|Deltaproteobacteria	S	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7780580_2	502025.Hoch_3335	3.417e-51	199.0	COG1409@1|root,COG1409@2|Bacteria,1NS3S@1224|Proteobacteria,43AFC@68525|delta/epsilon subdivisions,2WSTQ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
HKD2_k127_7780580_0	1192034.CAP_8441	3.272e-126	411.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,42RC9@68525|delta/epsilon subdivisions,2WN5U@28221|Deltaproteobacteria,2YWJ8@29|Myxococcales	28221|Deltaproteobacteria	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PEGA,Pkinase
HKD2_k127_7791681_4	1307761.L21SP2_2589	8.845e-14	77.0	COG1164@1|root,COG1164@2|Bacteria	2|Bacteria	E	metalloendopeptidase activity	-	-	3.4.15.1	ko:K01283	ko04614,ko04924,ko05142,ko05410,map04614,map04924,map05142,map05410	-	-	-	ko00000,ko00001,ko01000,ko01002,ko04090,ko04147	-	-	-	Peptidase_M2,Peptidase_M3
HKD2_k127_7791681_3	502025.Hoch_6691	4.534e-15	79.0	COG2010@1|root,COG2010@2|Bacteria,1PEGU@1224|Proteobacteria,434ZM@68525|delta/epsilon subdivisions,2X93H@28221|Deltaproteobacteria,2Z1PW@29|Myxococcales	28221|Deltaproteobacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7791681_5	1340493.JNIF01000004_gene1040	2.426e-09	66.0	2DR0H@1|root,339NS@2|Bacteria	2|Bacteria	S	TIGRFAM Caa(3)-type oxidase, subunit IV	-	-	1.9.3.1	ko:K02277	ko00190,ko01100,map00190,map01100	M00155	-	-	ko00000,ko00001,ko00002,ko01000	3.D.4.4	-	-	COX4_pro
HKD2_k127_7791681_2	1089550.ATTH01000001_gene1166	1.483e-69	243.0	COG1845@1|root,COG1845@2|Bacteria,4NDYG@976|Bacteroidetes,1FJ6D@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	C	Cytochrome c oxidase subunit III	coxP	-	1.9.3.1	ko:K02276	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.4,3.D.4.6	-	-	COX3
HKD2_k127_7791681_0	1089550.ATTH01000001_gene1167	3.828e-232	730.0	COG0843@1|root,COG0843@2|Bacteria,4NEH8@976|Bacteroidetes,1FIV6@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	coxN	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
HKD2_k127_7791681_1	880073.Calab_0304	5.447e-78	275.0	COG1622@1|root,COG2010@1|root,COG1622@2|Bacteria,COG2010@2|Bacteria,2NNSH@2323|unclassified Bacteria	2|Bacteria	C	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)	coxB	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006119,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009319,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016310,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0034641,GO:0042773,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0046034,GO:0046483,GO:0055086,GO:0055114,GO:0070069,GO:0071704,GO:0071944,GO:0072521,GO:0098796,GO:1901135,GO:1901360,GO:1901564,GO:1902494	1.9.3.1	ko:K02275,ko:K17223	ko00190,ko00920,ko01100,ko01120,map00190,map00920,map01100,map01120	M00155,M00595	R00081,R10151	RC00016,RC03151,RC03152	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2,COX2_TM,Cytochrom_C
HKD2_k127_7791681_6	264462.Bd0285	3.725e-08	57.0	COG1999@1|root,COG1999@2|Bacteria,1R9EM@1224|Proteobacteria,42N5F@68525|delta/epsilon subdivisions,2MTQK@213481|Bdellovibrionales,2WKG7@28221|Deltaproteobacteria	213481|Bdellovibrionales	S	protein SCO1 SenC PrrC involved in biogenesis of respiratory and photosynthetic systems	sco	-	-	ko:K07152	-	-	-	-	ko00000,ko03029	-	-	-	-
HKD2_k127_7792092_2	448385.sce7807	3.559e-91	307.0	COG0642@1|root,COG0840@1|root,COG1511@1|root,COG2770@1|root,COG0840@2|Bacteria,COG1511@2|Bacteria,COG2205@2|Bacteria,COG2770@2|Bacteria,1NRP8@1224|Proteobacteria,42MW4@68525|delta/epsilon subdivisions,2WKWD@28221|Deltaproteobacteria,2Z3GS@29|Myxococcales	28221|Deltaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	4HB_MCP_1,GAF_2,HAMP,HATPase_c,HisKA,Response_reg
HKD2_k127_7792092_0	1192034.CAP_1750	6.952e-169	547.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42P6D@68525|delta/epsilon subdivisions,2WM1P@28221|Deltaproteobacteria,2YUD4@29|Myxococcales	28221|Deltaproteobacteria	T	DNA-binding response regulator	-	-	-	ko:K07713	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD2_k127_7792092_7	246197.MXAN_7362	2.99e-08	60.0	COG0745@1|root,COG2199@1|root,COG2204@1|root,COG0745@2|Bacteria,COG2204@2|Bacteria,COG3706@2|Bacteria,1MXBG@1224|Proteobacteria,42NGW@68525|delta/epsilon subdivisions,2X7CV@28221|Deltaproteobacteria,2YUZ7@29|Myxococcales	28221|Deltaproteobacteria	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,Hpt,Response_reg
HKD2_k127_7792092_5	1173028.ANKO01000208_gene5102	9.749e-21	98.0	COG0745@1|root,COG0745@2|Bacteria,1G5ZH@1117|Cyanobacteria,1HHCH@1150|Oscillatoriales	1117|Cyanobacteria	KT	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
HKD2_k127_7792092_1	63737.Npun_F2346	3.389e-119	417.0	COG0642@1|root,COG0745@1|root,COG3609@1|root,COG0745@2|Bacteria,COG2205@2|Bacteria,COG3609@2|Bacteria,1G09B@1117|Cyanobacteria,1HIE5@1161|Nostocales	1117|Cyanobacteria	T	PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg
HKD2_k127_7792092_3	1192034.CAP_5647	8.246e-53	196.0	COG1360@1|root,COG1360@2|Bacteria,1MU4S@1224|Proteobacteria,42Q7D@68525|delta/epsilon subdivisions,2WN6T@28221|Deltaproteobacteria,2Z0I0@29|Myxococcales	28221|Deltaproteobacteria	N	OmpA family	-	-	-	ko:K02557	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1	-	-	OmpA
HKD2_k127_7792092_6	382464.ABSI01000012_gene2158	5.126e-15	85.0	COG0526@1|root,COG0526@2|Bacteria,46W0W@74201|Verrucomicrobia	74201|Verrucomicrobia	O	Thioredoxin-like	-	-	-	-	-	-	-	-	-	-	-	-	Redoxin
HKD2_k127_7792092_4	391625.PPSIR1_28478	2.046e-28	118.0	COG0607@1|root,COG3258@1|root,COG0607@2|Bacteria,COG3258@2|Bacteria	2|Bacteria	C	Cytochrome c	soxA	GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005507,GO:0005515,GO:0005575,GO:0005623,GO:0006091,GO:0006464,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0016491,GO:0016667,GO:0016669,GO:0016740,GO:0016782,GO:0016783,GO:0018192,GO:0018193,GO:0018198,GO:0018307,GO:0019417,GO:0019538,GO:0020037,GO:0022900,GO:0036211,GO:0042597,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0046872,GO:0046906,GO:0046914,GO:0046982,GO:0046983,GO:0048037,GO:0055114,GO:0071704,GO:0097159,GO:0098822,GO:1901363,GO:1901564	1.8.2.2	ko:K00406,ko:K03889,ko:K17222,ko:K19713	ko00190,ko00920,ko01100,ko01120,ko02020,map00190,map00920,map01100,map01120,map02020	M00151,M00156,M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	Cytochrome_CBB3,Rhodanese
HKD2_k127_7799540_3	1192034.CAP_3893	1.948e-30	135.0	COG1075@1|root,COG4786@1|root,COG1075@2|Bacteria,COG4786@2|Bacteria	2|Bacteria	N	Flagellar basal body rod	flgK	-	1.1.3.6	ko:K02396,ko:K03333	ko00984,ko01120,ko02040,map00984,map01120,map02040	-	R01459	RC00146	ko00000,ko00001,ko01000,ko02035	-	-	-	DUF2950,Flg_bb_rod,Flg_bbr_C
HKD2_k127_7799540_2	448385.sce7288	5.642e-43	164.0	COG1040@1|root,COG1040@2|Bacteria,1RHAV@1224|Proteobacteria,42SV9@68525|delta/epsilon subdivisions,2WPXX@28221|Deltaproteobacteria,2YVCY@29|Myxococcales	28221|Deltaproteobacteria	S	Phosphoribosyl transferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Pribosyltran
HKD2_k127_7799540_1	391625.PPSIR1_31628	1.79e-53	198.0	COG2267@1|root,COG2267@2|Bacteria,1MYEX@1224|Proteobacteria,43CP1@68525|delta/epsilon subdivisions,2X7WC@28221|Deltaproteobacteria,2Z2N6@29|Myxococcales	28221|Deltaproteobacteria	I	hydrolases or acyltransferases (alpha beta hydrolase superfamily)	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
HKD2_k127_7799540_0	448385.sce8174	3.023e-63	219.0	COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,42MSP@68525|delta/epsilon subdivisions,2WIUZ@28221|Deltaproteobacteria,2YTZB@29|Myxococcales	28221|Deltaproteobacteria	E	synthase homocitrate synthase family	-	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like
HKD2_k127_7805314_2	290397.Adeh_2112	6.945e-151	486.0	COG4108@1|root,COG4108@2|Bacteria,1MU7X@1224|Proteobacteria,42MAA@68525|delta/epsilon subdivisions,2WJZC@28221|Deltaproteobacteria,2YUE7@29|Myxococcales	28221|Deltaproteobacteria	J	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP	prfC	GO:0003674,GO:0003676,GO:0003723,GO:0003747,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0016150,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K02837	-	-	-	-	ko00000,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,RF3_C
HKD2_k127_7805314_6	243231.GSU2326	6.103e-28	121.0	COG3040@1|root,COG3040@2|Bacteria,1RIHP@1224|Proteobacteria,42SSW@68525|delta/epsilon subdivisions,2X6M9@28221|Deltaproteobacteria,43VBP@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Lipocalin-like domain	-	-	-	ko:K03098	-	-	-	-	ko00000,ko04147	-	-	-	Lipocalin_2
HKD2_k127_7805314_7	68170.KL590491_gene4828	5.243e-10	66.0	COG1846@1|root,COG1846@2|Bacteria,2IGUE@201174|Actinobacteria	201174|Actinobacteria	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_27,MarR_2
HKD2_k127_7805314_1	903818.KI912268_gene2799	0.0	1208.0	COG0841@1|root,COG0841@2|Bacteria,3Y35W@57723|Acidobacteria	57723|Acidobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
HKD2_k127_7805314_5	1121920.AUAU01000026_gene1475	9.693e-53	215.0	COG0845@1|root,COG0845@2|Bacteria,3Y2XB@57723|Acidobacteria	57723|Acidobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_D23
HKD2_k127_7805314_0	1071679.BG57_32355	0.0	1296.0	COG3408@1|root,COG3408@2|Bacteria,1QUN2@1224|Proteobacteria,2WHH3@28216|Betaproteobacteria,1KIP3@119060|Burkholderiaceae	28216|Betaproteobacteria	G	Glycogen debranching enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_63
HKD2_k127_7805314_3	1242864.D187_000249	1.263e-90	303.0	COG1940@1|root,COG1940@2|Bacteria,1NSQA@1224|Proteobacteria,4385Z@68525|delta/epsilon subdivisions,2X3FT@28221|Deltaproteobacteria,2YVWY@29|Myxococcales	28221|Deltaproteobacteria	GK	ROK family	-	-	2.7.1.63	ko:K00886	ko00010,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R02187,R02189	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
HKD2_k127_7805314_4	502025.Hoch_5810	4.554e-87	296.0	COG0006@1|root,COG0006@2|Bacteria,1MURT@1224|Proteobacteria	1224|Proteobacteria	E	Splits dipeptides with a prolyl residue in the C- terminal position	pepQ	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0009056,GO:0009987,GO:0016787,GO:0016805,GO:0019538,GO:0030145,GO:0034641,GO:0043167,GO:0043169,GO:0043170,GO:0043171,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0070011,GO:0070573,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575	3.4.13.9	ko:K01271	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
HKD2_k127_7812226_0	215803.DB30_3143	1.229e-209	672.0	COG0038@1|root,COG0517@1|root,COG0038@2|Bacteria,COG0517@2|Bacteria,1MV4K@1224|Proteobacteria,42PJQ@68525|delta/epsilon subdivisions,2WKR4@28221|Deltaproteobacteria,2YTY6@29|Myxococcales	28221|Deltaproteobacteria	P	Voltage gated chloride channel	-	-	-	ko:K03281	-	-	-	-	ko00000	2.A.49	-	-	CBS,Voltage_CLC
HKD2_k127_7812226_5	448385.sce3920	2.867e-26	114.0	COG1534@1|root,COG1534@2|Bacteria,1Q1J9@1224|Proteobacteria,42WJ8@68525|delta/epsilon subdivisions,2WRWD@28221|Deltaproteobacteria,2Z332@29|Myxococcales	28221|Deltaproteobacteria	J	CRS1_YhbY	yhbY	-	-	ko:K07574	-	-	-	-	ko00000,ko03009	-	-	-	CRS1_YhbY
HKD2_k127_7812226_3	1089547.KB913013_gene4646	1.873e-43	165.0	COG2335@1|root,COG2335@2|Bacteria,4NMPI@976|Bacteroidetes,47XS3@768503|Cytophagia	976|Bacteroidetes	M	Four repeated domains in the Fasciclin I family of proteins, present in many other contexts.	-	-	-	-	-	-	-	-	-	-	-	-	Fasciclin
HKD2_k127_7812226_4	504832.OCAR_7249	1.176e-38	160.0	COG2132@1|root,COG3474@1|root,COG2132@2|Bacteria,COG3474@2|Bacteria,1MV74@1224|Proteobacteria,2U1BK@28211|Alphaproteobacteria,3JV1C@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Copper binding proteins, plastocyanin/azurin family	-	-	1.7.2.1	ko:K00368	ko00910,ko01120,map00910,map01120	M00529	R00783,R00785	RC00086	ko00000,ko00001,ko00002,ko01000	-	-	-	Copper-bind,Cu-oxidase_2,Cu-oxidase_3,Cytochrom_C
HKD2_k127_7812226_2	448385.sce9205	5.582e-80	287.0	COG0515@1|root,COG0515@2|Bacteria	448385.sce9205|-	KLT	protein kinase activity	-	-	2.7.11.1	ko:K08884	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	-
HKD2_k127_7812226_1	278957.ABEA03000197_gene422	1.759e-92	307.0	COG0841@1|root,COG0841@2|Bacteria,46SDW@74201|Verrucomicrobia,3K7E7@414999|Opitutae	414999|Opitutae	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
HKD2_k127_78201_9	1089544.KB912942_gene1381	1.597e-92	309.0	COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria,4DZX5@85010|Pseudonocardiales	201174|Actinobacteria	IQ	PFAM AMP-dependent synthetase	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
HKD2_k127_78201_25	204669.Acid345_2079	3.113e-16	85.0	COG3391@1|root,COG3391@2|Bacteria,3Y7M7@57723|Acidobacteria,2JP55@204432|Acidobacteriia	2|Bacteria	S	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	ASH,BNR_assoc_N,Big_3_5,HYR,Laminin_G_3,TIG
HKD2_k127_78201_1	479434.Sthe_1720	3.233e-137	449.0	COG0427@1|root,COG0427@2|Bacteria,2G60V@200795|Chloroflexi	200795|Chloroflexi	C	PFAM Acetyl-CoA hydrolase transferase	-	-	3.1.2.1	ko:K01067	ko00620,map00620	-	R00227	RC00004,RC00012	ko00000,ko00001,ko01000	-	-	-	AcetylCoA_hyd_C,AcetylCoA_hydro
HKD2_k127_78201_4	1192034.CAP_5764	2.103e-127	418.0	COG4690@1|root,COG4690@2|Bacteria,1RBRZ@1224|Proteobacteria	1224|Proteobacteria	E	dipeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C69
HKD2_k127_78201_30	44689.DDB0231275	5.113e-07	61.0	2CJC4@1|root,2RCK0@2759|Eukaryota,3XB2M@554915|Amoebozoa	554915|Amoebozoa	G	Has antibacterial activity	-	GO:0000270,GO:0003674,GO:0003796,GO:0003824,GO:0004553,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006022,GO:0006026,GO:0006027,GO:0006807,GO:0006810,GO:0006897,GO:0006909,GO:0006950,GO:0006952,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009253,GO:0009605,GO:0009607,GO:0009617,GO:0016192,GO:0016787,GO:0016798,GO:0030203,GO:0031410,GO:0031974,GO:0031982,GO:0031983,GO:0042742,GO:0043170,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043233,GO:0044422,GO:0044424,GO:0044444,GO:0044464,GO:0050830,GO:0050896,GO:0051179,GO:0051234,GO:0051704,GO:0051707,GO:0061783,GO:0071704,GO:0097708,GO:0098542,GO:0098657,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_78201_28	448385.sce3977	1.068e-09	70.0	2AH09@1|root,31793@2|Bacteria,1PYJ1@1224|Proteobacteria,435DZ@68525|delta/epsilon subdivisions,2WZRH@28221|Deltaproteobacteria,2Z2KK@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_78201_26	264462.Bd2272	1.434e-14	87.0	COG0526@1|root,COG0526@2|Bacteria,1P3KQ@1224|Proteobacteria,431Y2@68525|delta/epsilon subdivisions,2MU82@213481|Bdellovibrionales,2WWSS@28221|Deltaproteobacteria	213481|Bdellovibrionales	O	Redoxin	-	-	-	-	-	-	-	-	-	-	-	-	Redoxin
HKD2_k127_78201_5	404589.Anae109_4152	4.057e-121	404.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2YX5F@29|Myxococcales	28221|Deltaproteobacteria	T	response regulator	nla19	-	-	ko:K07713	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD2_k127_78201_15	215803.DB30_0461	3.406e-36	154.0	COG4191@1|root,COG5002@1|root,COG4191@2|Bacteria,COG5002@2|Bacteria,1RCM9@1224|Proteobacteria,43BK1@68525|delta/epsilon subdivisions,2X6XW@28221|Deltaproteobacteria,2YZAU@29|Myxococcales	28221|Deltaproteobacteria	T	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_4,Response_reg
HKD2_k127_78201_18	1125863.JAFN01000001_gene1516	3.964e-26	124.0	COG3637@1|root,COG3637@2|Bacteria,1Q8YQ@1224|Proteobacteria,42YH1@68525|delta/epsilon subdivisions,2WTT0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_78201_13	331678.Cphamn1_0650	1.679e-39	154.0	COG3794@1|root,COG3794@2|Bacteria	2|Bacteria	C	PFAM blue (type 1) copper domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
HKD2_k127_78201_14	269799.Gmet_1809	1.062e-38	151.0	COG3474@1|root,COG3474@2|Bacteria,1QUNA@1224|Proteobacteria,42PVG@68525|delta/epsilon subdivisions,2X7M4@28221|Deltaproteobacteria,43VY9@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Cytochrome c7 and related cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_78201_0	1232410.KI421425_gene1565	3.13e-152	514.0	COG0437@1|root,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,42NEG@68525|delta/epsilon subdivisions,2WKHA@28221|Deltaproteobacteria,43TY6@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	actB	-	-	ko:K00184	-	-	-	-	ko00000	5.A.3	-	-	Fer4_7,Molybdop_Fe4S4,Molybdopterin,Molydop_binding
HKD2_k127_78201_6	1379698.RBG1_1C00001G1304	1.308e-115	417.0	COG5557@1|root,COG5557@2|Bacteria,2NNNQ@2323|unclassified Bacteria	2|Bacteria	C	Polysulphide reductase, NrfD	actC	-	-	ko:K00185	-	-	-	-	ko00000	5.A.3	-	-	NrfD
HKD2_k127_78201_32	177437.HRM2_15140	5.224e-06	55.0	COG2010@1|root,COG2010@2|Bacteria,1RDVX@1224|Proteobacteria,42WYA@68525|delta/epsilon subdivisions,2WT1Y@28221|Deltaproteobacteria,2MNSF@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Protein of unknown function (DUF3341)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3341
HKD2_k127_78201_27	867903.ThesuDRAFT_00843	1.4e-12	78.0	COG1276@1|root,COG2010@1|root,COG1276@2|Bacteria,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	copC	-	-	ko:K07245,ko:K14166	-	-	-	-	ko00000,ko02000	9.B.62.1	-	-	AhpC-TSA,CopC,CopD,Cytochrome_CBB3
HKD2_k127_78201_17	596152.DesU5LDRAFT_2590	5.136e-31	139.0	COG5557@1|root,COG5557@2|Bacteria,1QURB@1224|Proteobacteria,43BT1@68525|delta/epsilon subdivisions,2X73S@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Pfam Polysulphide reductase, NrfD	actF	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_78201_2	671143.DAMO_0766	2.023e-134	449.0	COG0493@1|root,COG1143@1|root,COG0493@2|Bacteria,COG1143@2|Bacteria,2NNUW@2323|unclassified Bacteria	2|Bacteria	C	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	pcmB	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6,1.97.1.9	ko:K03388,ko:K12527	ko00450,ko00680,ko01100,ko01120,ko01200,map00450,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R07229,R11928,R11931,R11943,R11944	RC00011,RC02420	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_20,FlpD,Pyr_redox_2,Pyr_redox_3
HKD2_k127_78201_24	671143.DAMO_1672	5.29e-18	99.0	COG0723@1|root,COG0723@2|Bacteria,2NRUZ@2323|unclassified Bacteria	2|Bacteria	C	Rieske [2Fe-2S] domain	-	-	1.10.9.1	ko:K02636,ko:K03886	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00151,M00162	R03817,R08409	RC01002	ko00000,ko00001,ko00002,ko00194,ko01000	-	-	-	Rieske
HKD2_k127_78201_8	671143.DAMO_0768	1.321e-102	358.0	COG1290@1|root,COG1290@2|Bacteria,2NP8C@2323|unclassified Bacteria	2|Bacteria	C	Cytochrome b(N-terminal)/b6/petB	petB	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_B_C,Cytochrome_B
HKD2_k127_78201_11	1125863.JAFN01000001_gene2793	1.536e-49	204.0	COG2010@1|root,COG3258@1|root,COG2010@2|Bacteria,COG3258@2|Bacteria,1RJJ2@1224|Proteobacteria,42SCM@68525|delta/epsilon subdivisions,2WPS4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Cytochrome c	pcmF	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C
HKD2_k127_78201_23	861299.J421_1437	1.511e-19	97.0	COG3794@1|root,COG3794@2|Bacteria	2|Bacteria	C	PFAM blue (type 1) copper domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupredoxin_1
HKD2_k127_78201_19	1125863.JAFN01000001_gene1516	1.254e-20	107.0	COG3637@1|root,COG3637@2|Bacteria,1Q8YQ@1224|Proteobacteria,42YH1@68525|delta/epsilon subdivisions,2WTT0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_78201_21	861299.J421_4438	6.228e-20	100.0	COG3794@1|root,COG3794@2|Bacteria	2|Bacteria	C	PFAM blue (type 1) copper domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupredoxin_1
HKD2_k127_78201_20	326427.Cagg_0327	4.384e-20	100.0	COG3241@1|root,COG3241@2|Bacteria,2G9Q8@200795|Chloroflexi,375YV@32061|Chloroflexia	32061|Chloroflexia	C	Copper binding proteins, plastocyanin/azurin family	-	GO:0008150,GO:0008152,GO:0055114	-	-	-	-	-	-	-	-	-	-	Copper-bind
HKD2_k127_78201_12	1192034.CAP_2118	3.65e-47	182.0	COG2010@1|root,COG2010@2|Bacteria,1PD95@1224|Proteobacteria,43E5K@68525|delta/epsilon subdivisions,2WZSQ@28221|Deltaproteobacteria,2Z2P1@29|Myxococcales	28221|Deltaproteobacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_78201_33	557599.MKAN_15660	5.315e-06	56.0	COG1309@1|root,COG1309@2|Bacteria,2I8NQ@201174|Actinobacteria,23712@1762|Mycobacteriaceae	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
HKD2_k127_78201_3	391625.PPSIR1_18015	2.984e-132	443.0	COG1902@1|root,COG1902@2|Bacteria,1MVE0@1224|Proteobacteria,42NA7@68525|delta/epsilon subdivisions,2WIN5@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM NADH flavin oxidoreductase NADH oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_FMN
HKD2_k127_78201_10	1211813.CAPH01000009_gene97	1.22e-55	214.0	COG0300@1|root,COG0300@2|Bacteria,4NIAI@976|Bacteroidetes,2FRZY@200643|Bacteroidia	976|Bacteroidetes	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	ko:K07124	-	-	-	-	ko00000	-	-	-	adh_short
HKD2_k127_78201_7	876269.ARWA01000001_gene2870	1.222e-112	390.0	COG1392@1|root,COG1392@2|Bacteria,1MW5V@1224|Proteobacteria,2TV2M@28211|Alphaproteobacteria,3NAUY@45404|Beijerinckiaceae	28211|Alphaproteobacteria	P	Phosphate transport regulator	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_78201_29	1121896.JMLU01000005_gene2483	3.691e-07	61.0	COG3942@1|root,COG3942@2|Bacteria,4NKM5@976|Bacteroidetes,1HZ3I@117743|Flavobacteriia,2NWD4@237|Flavobacterium	976|Bacteroidetes	S	CHAP domain	-	-	-	-	-	-	-	-	-	-	-	-	CHAP
HKD2_k127_7821206_0	1254432.SCE1572_17995	3.371e-196	631.0	COG1651@1|root,COG1651@2|Bacteria,1RKYF@1224|Proteobacteria,42T64@68525|delta/epsilon subdivisions,2WP82@28221|Deltaproteobacteria,2YU4W@29|Myxococcales	28221|Deltaproteobacteria	O	Thioredoxin	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_4
HKD2_k127_7834050_0	1397528.Q671_06355	2.91e-45	183.0	COG3703@1|root,COG3703@2|Bacteria,1QA7D@1224|Proteobacteria,1S2MT@1236|Gammaproteobacteria,1XJWH@135619|Oceanospirillales	135619|Oceanospirillales	P	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides	-	-	-	-	-	-	-	-	-	-	-	-	ChaC
HKD2_k127_7834050_1	1192034.CAP_6467	4.589e-06	58.0	COG1262@1|root,COG1361@1|root,COG3055@1|root,COG5184@1|root,COG1262@2|Bacteria,COG1361@2|Bacteria,COG3055@2|Bacteria,COG5184@2|Bacteria,1Q2FP@1224|Proteobacteria,4381R@68525|delta/epsilon subdivisions,2X3BT@28221|Deltaproteobacteria,2YVB5@29|Myxococcales	28221|Deltaproteobacteria	DZ	Homologues of snake disintegrins	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7836846_6	485913.Krac_12164	5.742e-17	80.0	COG2314@1|root,COG2314@2|Bacteria	2|Bacteria	J	TM2 domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4864,TM2,zinc_ribbon_2
HKD2_k127_7836846_1	215803.DB30_6435	2.699e-131	452.0	COG0308@1|root,COG0308@2|Bacteria,1MUCI@1224|Proteobacteria,437F0@68525|delta/epsilon subdivisions,2XA2R@28221|Deltaproteobacteria,2YTSS@29|Myxococcales	28221|Deltaproteobacteria	E	ERAP1-like C-terminal domain	-	-	3.4.11.14	ko:K01263	-	-	-	-	ko00000,ko01000	-	-	-	ERAP1_C,Peptidase_M1
HKD2_k127_7836846_3	215803.DB30_8106	1.663e-114	382.0	COG4638@1|root,COG4638@2|Bacteria,1P1X2@1224|Proteobacteria,439JY@68525|delta/epsilon subdivisions,2X4WM@28221|Deltaproteobacteria,2YZRF@29|Myxococcales	28221|Deltaproteobacteria	P	Rieske [2Fe-2S] domain	-	-	-	-	-	-	-	-	-	-	-	-	Rieske
HKD2_k127_7836846_0	246197.MXAN_5575	2.763e-171	550.0	COG1488@1|root,COG1488@2|Bacteria,1MV8U@1224|Proteobacteria,42Q2U@68525|delta/epsilon subdivisions,2WM6I@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP	pncB	-	6.3.4.21	ko:K00763	ko00760,ko01100,map00760,map01100	-	R01724	RC00033	ko00000,ko00001,ko01000	-	-	-	NAPRTase
HKD2_k127_7836846_2	378806.STAUR_6233	6.474e-120	403.0	COG1335@1|root,COG1335@2|Bacteria,1RCGZ@1224|Proteobacteria,42ZKX@68525|delta/epsilon subdivisions,2WUY9@28221|Deltaproteobacteria,2YZ7A@29|Myxococcales	28221|Deltaproteobacteria	Q	COG1335 Amidases related to nicotinamidase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7836846_5	1242864.D187_006364	4.44e-67	252.0	COG1051@1|root,COG1051@2|Bacteria,1QTT4@1224|Proteobacteria,42SX4@68525|delta/epsilon subdivisions,2WPWK@28221|Deltaproteobacteria,2YY1W@29|Myxococcales	28221|Deltaproteobacteria	F	Belongs to the Nudix hydrolase family	-	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX
HKD2_k127_7836846_4	448385.sce3841	1.464e-110	364.0	COG0714@1|root,COG0714@2|Bacteria,1QA7C@1224|Proteobacteria,4342N@68525|delta/epsilon subdivisions,2X4WR@28221|Deltaproteobacteria,2YZRP@29|Myxococcales	28221|Deltaproteobacteria	S	AAA domain (dynein-related subfamily)	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_5
HKD2_k127_7837031_1	1254432.SCE1572_35380	1.336e-98	340.0	COG0457@1|root,COG0457@2|Bacteria,1PDTX@1224|Proteobacteria,42RK5@68525|delta/epsilon subdivisions,2WNZC@28221|Deltaproteobacteria,2YW1B@29|Myxococcales	28221|Deltaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	SPOR,TPR_1,TPR_11,TPR_16,TPR_19,TPR_2,TPR_8
HKD2_k127_7837031_0	448385.sce5944	7.721e-101	348.0	COG0457@1|root,COG1729@1|root,COG0457@2|Bacteria,COG1729@2|Bacteria,1MX82@1224|Proteobacteria,42TQ9@68525|delta/epsilon subdivisions,2WR3B@28221|Deltaproteobacteria,2YUCZ@29|Myxococcales	28221|Deltaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_6
HKD2_k127_7843690_2	1192034.CAP_7162	1.155e-118	391.0	COG0768@1|root,COG0768@2|Bacteria,1MUNY@1224|Proteobacteria,42M1T@68525|delta/epsilon subdivisions,2WK0W@28221|Deltaproteobacteria,2YTT3@29|Myxococcales	28221|Deltaproteobacteria	M	penicillin-binding protein	ftsI	-	3.4.16.4	ko:K03587	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011,ko03036	-	-	-	PASTA,PBP_dimer,Transpeptidase
HKD2_k127_7843690_1	1254432.SCE1572_10495	1.141e-147	485.0	COG0769@1|root,COG0769@2|Bacteria,1MU6P@1224|Proteobacteria,42NKY@68525|delta/epsilon subdivisions,2WJJG@28221|Deltaproteobacteria,2YU1E@29|Myxococcales	28221|Deltaproteobacteria	M	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan	murE	GO:0000270,GO:0003674,GO:0003824,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008765,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	6.3.2.13	ko:K01928	ko00300,ko00550,map00300,map00550	-	R02788	RC00064,RC00090	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
HKD2_k127_7843690_3	1254432.SCE1572_43050	2.381e-86	305.0	COG0770@1|root,COG0770@2|Bacteria,1QTSF@1224|Proteobacteria,42MXF@68525|delta/epsilon subdivisions,2WIJZ@28221|Deltaproteobacteria,2YXRU@29|Myxococcales	28221|Deltaproteobacteria	M	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein	murF	-	6.3.2.10	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	-	R04573,R04617	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
HKD2_k127_7843690_0	448385.sce1661	1.491e-177	566.0	COG0472@1|root,COG0472@2|Bacteria,1MUTK@1224|Proteobacteria,42MCP@68525|delta/epsilon subdivisions,2WJDS@28221|Deltaproteobacteria,2YWXN@29|Myxococcales	28221|Deltaproteobacteria	M	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan	mraY	-	2.7.8.13	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	-	R05629,R05630	RC00002,RC02753	ko00000,ko00001,ko01000,ko01011	9.B.146	-	iAF987.Gmet_0409	Glycos_transf_4,MraY_sig1
HKD2_k127_7843690_4	448385.sce1662	3.862e-60	215.0	COG0771@1|root,COG0771@2|Bacteria,1MVYD@1224|Proteobacteria,42MJY@68525|delta/epsilon subdivisions,2WJAQ@28221|Deltaproteobacteria,2YU89@29|Myxococcales	28221|Deltaproteobacteria	M	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)	murD	-	6.3.2.9	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R02783	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	AlaDh_PNT_C,FAD_binding_3,Mur_ligase_C,Mur_ligase_M,NAD_binding_8
HKD2_k127_7844157_2	1123389.ATXJ01000050_gene1834	3.245e-05	54.0	2CP7W@1|root,32MRP@2|Bacteria,1WKBJ@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7844157_1	378806.STAUR_7734	5.968e-48	179.0	2F1YR@1|root,33UY5@2|Bacteria,1NVEZ@1224|Proteobacteria,438Q2@68525|delta/epsilon subdivisions,2X8VY@28221|Deltaproteobacteria,2YXGR@29|Myxococcales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF1318)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1318
HKD2_k127_7844157_0	1340493.JNIF01000003_gene1972	1.495e-62	231.0	COG0841@1|root,COG0841@2|Bacteria,3Y2RX@57723|Acidobacteria	2|Bacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
HKD2_k127_7857685_1	483219.LILAB_04525	1.19e-46	185.0	COG0392@1|root,COG0392@2|Bacteria,1QDIG@1224|Proteobacteria,434TJ@68525|delta/epsilon subdivisions,2WZ4H@28221|Deltaproteobacteria,2Z1B9@29|Myxococcales	28221|Deltaproteobacteria	S	Lysylphosphatidylglycerol synthase TM region	-	-	-	-	-	-	-	-	-	-	-	-	LPG_synthase_TM
HKD2_k127_7857685_0	1379270.AUXF01000003_gene3635	2.133e-154	502.0	COG0154@1|root,COG0154@2|Bacteria,1ZUIB@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Amidase	-	-	3.5.1.4	ko:K01426	ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120	-	R02540,R03096,R03180,R03909,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000	-	-	-	Amidase
HKD2_k127_7857685_3	1150599.MPHLEI_05592	4.961e-14	79.0	COG3693@1|root,COG3693@2|Bacteria,2GN8V@201174|Actinobacteria,23583@1762|Mycobacteriaceae	201174|Actinobacteria	G	Belongs to the glycosyl hydrolase 5 (cellulase A) family	-	-	-	-	-	-	-	-	-	-	-	-	Cellulase,Glyco_hydro_42
HKD2_k127_7862384_0	448385.sce7937	1.148e-76	259.0	COG0522@1|root,COG0522@2|Bacteria,1MW0U@1224|Proteobacteria,42M5X@68525|delta/epsilon subdivisions,2WJGN@28221|Deltaproteobacteria,2YU1D@29|Myxococcales	28221|Deltaproteobacteria	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit	rpsD	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0019222,GO:0019843,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S4,S4
HKD2_k127_7879253_7	448385.sce2451	3.707e-31	132.0	COG1266@1|root,COG1266@2|Bacteria,1R5BW@1224|Proteobacteria,434JF@68525|delta/epsilon subdivisions,2WYWP@28221|Deltaproteobacteria,2Z0TD@29|Myxococcales	28221|Deltaproteobacteria	S	CAAX protease self-immunity	-	-	-	-	-	-	-	-	-	-	-	-	Abi
HKD2_k127_7879253_0	404589.Anae109_1264	1.455e-148	484.0	COG0008@1|root,COG0008@2|Bacteria,1MUCR@1224|Proteobacteria,42MAI@68525|delta/epsilon subdivisions,2WJ8M@28221|Deltaproteobacteria,2YV5P@29|Myxococcales	28221|Deltaproteobacteria	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
HKD2_k127_7879253_6	797209.ZOD2009_13276	3.296e-32	142.0	COG0693@1|root,arCOG00769@2157|Archaea,2XV38@28890|Euryarchaeota,23RWT@183963|Halobacteria	183963|Halobacteria	S	intracellular protease amidase	-	-	-	-	-	-	-	-	-	-	-	-	DJ-1_PfpI
HKD2_k127_7879253_4	1254432.SCE1572_07730	1.77e-50	190.0	COG3206@1|root,COG3206@2|Bacteria,1QZTF@1224|Proteobacteria,43CNF@68525|delta/epsilon subdivisions,2X7VS@28221|Deltaproteobacteria,2Z3IM@29|Myxococcales	28221|Deltaproteobacteria	M	Domain of unknown function (DUF4349)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4349
HKD2_k127_7879253_5	1254432.SCE1572_14760	1.47e-33	134.0	29Z2K@1|root,30M04@2|Bacteria,1QAUM@1224|Proteobacteria,43E42@68525|delta/epsilon subdivisions,2WZNA@28221|Deltaproteobacteria,2Z2EY@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7879253_1	593750.Metfor_1459	1.343e-77	264.0	COG1945@1|root,arCOG04490@2157|Archaea,2XX0H@28890|Euryarchaeota,2N9J2@224756|Methanomicrobia	224756|Methanomicrobia	E	Belongs to the PdaD family	pdaD	-	4.1.1.19	ko:K02626	ko00330,ko01100,map00330,map01100	M00133	R00566	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	PvlArgDC
HKD2_k127_7879253_2	1242864.D187_000463	1.261e-73	260.0	COG1181@1|root,COG1181@2|Bacteria,1N4F5@1224|Proteobacteria,42NYM@68525|delta/epsilon subdivisions,2WKTX@28221|Deltaproteobacteria,2Z0D8@29|Myxococcales	28221|Deltaproteobacteria	F	Belongs to the D-alanine--D-alanine ligase family	ddlB1	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C
HKD2_k127_7879253_3	1192034.CAP_0859	8.634e-69	241.0	COG2386@1|root,COG2386@2|Bacteria,1QF23@1224|Proteobacteria,42RAM@68525|delta/epsilon subdivisions,2WMS1@28221|Deltaproteobacteria,2YVDV@29|Myxococcales	28221|Deltaproteobacteria	U	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes	ccmB	-	-	ko:K02194	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.107	-	-	CcmB
HKD2_k127_7880079_0	1254432.SCE1572_33725	1.321e-164	533.0	COG0248@1|root,COG2206@1|root,COG0248@2|Bacteria,COG2206@2|Bacteria,1MV35@1224|Proteobacteria,42NIH@68525|delta/epsilon subdivisions,2WN60@28221|Deltaproteobacteria,2YUZ0@29|Myxococcales	28221|Deltaproteobacteria	FP	Ppx/GppA phosphatase family	gppA-2	-	3.6.1.11,3.6.1.40	ko:K01524	ko00230,map00230	-	R03409	RC00002	ko00000,ko00001,ko01000	-	-	-	HD,Ppx-GppA
HKD2_k127_7895862_6	1226325.HMPREF1548_03946	1.071e-11	79.0	COG0457@1|root,COG0666@1|root,COG0457@2|Bacteria,COG0666@2|Bacteria,1UKYH@1239|Firmicutes,24B57@186801|Clostridia,36FBV@31979|Clostridiaceae	186801|Clostridia	O	tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_12,TPR_16,TPR_19,TPR_2,TPR_8
HKD2_k127_7895862_3	1278073.MYSTI_06472	6.309e-26	125.0	COG2391@1|root,COG2391@2|Bacteria,1MZ3A@1224|Proteobacteria,42XXQ@68525|delta/epsilon subdivisions,2WSR1@28221|Deltaproteobacteria,2YVMI@29|Myxococcales	28221|Deltaproteobacteria	S	transporter component	-	-	-	ko:K07112	-	-	-	-	ko00000	-	-	-	Sulf_transp
HKD2_k127_7895862_4	1057002.KB905370_gene3507	1.462e-24	114.0	COG2391@1|root,COG2391@2|Bacteria,1MZC0@1224|Proteobacteria,2U99K@28211|Alphaproteobacteria,4BFDG@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	transporter component	-	-	-	ko:K07112	-	-	-	-	ko00000	-	-	-	Sulf_transp
HKD2_k127_7895862_5	1242864.D187_006517	7.544e-14	82.0	2B9U8@1|root,32374@2|Bacteria,1QAN8@1224|Proteobacteria,4356P@68525|delta/epsilon subdivisions,2X968@28221|Deltaproteobacteria,2Z26H@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7895862_1	1173024.KI912151_gene1765	7.419e-48	181.0	2AWGV@1|root,31ND8@2|Bacteria,1G6HG@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7895862_2	345341.KUTG_03819	1.018e-34	142.0	2DX5D@1|root,343EZ@2|Bacteria,2IK8W@201174|Actinobacteria,4E3EU@85010|Pseudonocardiales	201174|Actinobacteria	S	TIR domain	-	-	-	-	-	-	-	-	-	-	-	-	TIR_2
HKD2_k127_7895862_0	1121272.KB903272_gene112	9.355e-79	289.0	COG1192@1|root,COG1192@2|Bacteria,2IASX@201174|Actinobacteria	201174|Actinobacteria	D	CobQ/CobB/MinD/ParA nucleotide binding domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_31,NB-ARC,TIR_2,TPR_10,TPR_12
HKD2_k127_7895862_7	426117.M446_6572	1.089e-05	59.0	COG0846@1|root,COG0846@2|Bacteria,1NH9W@1224|Proteobacteria	1224|Proteobacteria	K	SIR2-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SIR2_2
HKD2_k127_7895862_8	1122971.BAME01000017_gene2023	4.595e-05	57.0	COG1649@1|root,COG3509@1|root,COG1649@2|Bacteria,COG3509@2|Bacteria,4NENB@976|Bacteroidetes,2G37K@200643|Bacteroidia,22Y1C@171551|Porphyromonadaceae	976|Bacteroidetes	Q	Carbohydrate family 9 binding domain-like	-	-	-	-	-	-	-	-	-	-	-	-	CBM9_1
HKD2_k127_7897621_0	1192034.CAP_7257	1.015e-50	201.0	COG1470@1|root,COG1470@2|Bacteria,1P6QQ@1224|Proteobacteria,4385T@68525|delta/epsilon subdivisions,2X3FM@28221|Deltaproteobacteria,2YVWE@29|Myxococcales	28221|Deltaproteobacteria	S	cell adhesion involved in biofilm formation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7898745_2	1192034.CAP_7161	1.437e-79	299.0	COG0769@1|root,COG0769@2|Bacteria,1MU6P@1224|Proteobacteria,42NKY@68525|delta/epsilon subdivisions,2WJJG@28221|Deltaproteobacteria,2YU1E@29|Myxococcales	28221|Deltaproteobacteria	M	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan	murE	GO:0000270,GO:0003674,GO:0003824,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008765,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	6.3.2.13	ko:K01928	ko00300,ko00550,map00300,map00550	-	R02788	RC00064,RC00090	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
HKD2_k127_7898745_0	1192034.CAP_7162	3.242e-248	790.0	COG0768@1|root,COG0768@2|Bacteria,1MUNY@1224|Proteobacteria,42M1T@68525|delta/epsilon subdivisions,2WK0W@28221|Deltaproteobacteria,2YTT3@29|Myxococcales	28221|Deltaproteobacteria	M	penicillin-binding protein	ftsI	-	3.4.16.4	ko:K03587	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011,ko03036	-	-	-	PASTA,PBP_dimer,Transpeptidase
HKD2_k127_7898745_1	1254432.SCE1572_10480	1.152e-105	352.0	COG0275@1|root,COG0275@2|Bacteria,1MUT4@1224|Proteobacteria,42N5Q@68525|delta/epsilon subdivisions,2WJ8J@28221|Deltaproteobacteria,2YUXX@29|Myxococcales	28221|Deltaproteobacteria	J	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA	rsmH	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.199	ko:K03438	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltransf_5
HKD2_k127_7898745_4	1254432.SCE1572_10475	5.815e-28	116.0	COG2001@1|root,COG2001@2|Bacteria,1RHCG@1224|Proteobacteria,42TRZ@68525|delta/epsilon subdivisions,2WQRI@28221|Deltaproteobacteria,2YYCH@29|Myxococcales	28221|Deltaproteobacteria	K	Belongs to the MraZ family	mraZ	GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031333,GO:0043254,GO:0043565,GO:0044087,GO:0044212,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2000142,GO:2000143,GO:2001141	-	ko:K03925	-	-	-	-	ko00000	-	-	-	MraZ
HKD2_k127_7901244_0	378806.STAUR_7453	1.081e-175	560.0	COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,42NSP@68525|delta/epsilon subdivisions,2WMAD@28221|Deltaproteobacteria,2YTY4@29|Myxococcales	28221|Deltaproteobacteria	C	Acyl-CoA dehydrogenase N terminal	-	-	1.3.8.1	ko:K00248	ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212	-	R01175,R01178,R02661,R03172,R04751	RC00052,RC00068,RC00076,RC00120,RC00148	ko00000,ko00001,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N
HKD2_k127_7902270_6	1254432.SCE1572_23515	1.699e-64	226.0	COG3177@1|root,COG3177@2|Bacteria,1Q2H9@1224|Proteobacteria,4383Y@68525|delta/epsilon subdivisions,2X3DX@28221|Deltaproteobacteria,2YVMK@29|Myxococcales	28221|Deltaproteobacteria	S	Fic/DOC family	-	-	-	-	-	-	-	-	-	-	-	-	Fic
HKD2_k127_7902270_1	1192034.CAP_5056	1.123e-173	561.0	COG0497@1|root,COG0497@2|Bacteria,1MUNP@1224|Proteobacteria,42N50@68525|delta/epsilon subdivisions,2WJ23@28221|Deltaproteobacteria,2YTSW@29|Myxococcales	28221|Deltaproteobacteria	L	May be involved in recombinational repair of damaged DNA	recN	-	-	ko:K03631	-	-	-	-	ko00000,ko03400	-	-	-	AAA_23,SMC_N
HKD2_k127_7902270_8	1192034.CAP_0370	5.595e-48	186.0	COG2355@1|root,COG2355@2|Bacteria,1MWEW@1224|Proteobacteria,42NXB@68525|delta/epsilon subdivisions,2WMBF@28221|Deltaproteobacteria,2YXC1@29|Myxococcales	28221|Deltaproteobacteria	E	Membrane dipeptidase (Peptidase family M19)	-	-	3.4.13.19	ko:K01273	-	-	-	-	ko00000,ko00537,ko01000,ko01002,ko04147	-	-	-	Peptidase_M19
HKD2_k127_7902270_3	448385.sce1069	2.747e-122	396.0	COG0024@1|root,COG0024@2|Bacteria,1MU99@1224|Proteobacteria,42MM5@68525|delta/epsilon subdivisions,2WJMN@28221|Deltaproteobacteria,2YU2H@29|Myxococcales	28221|Deltaproteobacteria	J	Methionine aminopeptidase	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24,SEC-C
HKD2_k127_7902270_14	1254432.SCE1572_07705	8.651e-20	94.0	COG0694@1|root,COG0694@2|Bacteria	2|Bacteria	O	iron-sulfur cluster assembly	nifU	-	-	ko:K07126,ko:K13819	-	-	-	-	ko00000	-	-	-	Fer2_BFD,NifU,NifU_N
HKD2_k127_7902270_13	448385.sce9012	1.672e-22	111.0	COG1716@1|root,COG1716@2|Bacteria,1PEBF@1224|Proteobacteria,433IZ@68525|delta/epsilon subdivisions,2WXWM@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Forkhead associated domain	-	-	-	-	-	-	-	-	-	-	-	-	FHA
HKD2_k127_7902270_5	1192034.CAP_0383	8.661e-69	243.0	COG1716@1|root,COG1716@2|Bacteria	2|Bacteria	T	histone H2A K63-linked ubiquitination	-	-	-	-	-	-	-	-	-	-	-	-	FHA,Yop-YscD_cpl
HKD2_k127_7902270_15	1304888.ATWF01000001_gene2023	5.036e-06	56.0	COG5512@1|root,COG5512@2|Bacteria,2GFYI@200930|Deferribacteres	200930|Deferribacteres	S	Protein of unknown function (DUF721)	-	-	-	-	-	-	-	-	-	-	-	-	DUF721
HKD2_k127_7902270_10	880072.Desac_0711	4.38e-30	123.0	COG0720@1|root,COG0720@2|Bacteria,1RI4P@1224|Proteobacteria,42TJ5@68525|delta/epsilon subdivisions,2WQ2Z@28221|Deltaproteobacteria,2MRZN@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	PFAM 6-pyruvoyl tetrahydropterin synthase	queD	-	4.1.2.50,4.2.3.12	ko:K01737	ko00790,ko01100,map00790,map01100	M00842,M00843	R04286,R09959	RC01117,RC02846,RC02847	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	PTPS
HKD2_k127_7902270_11	867845.KI911784_gene2774	7.73e-29	136.0	COG1413@1|root,COG1674@1|root,COG5635@1|root,COG1413@2|Bacteria,COG1674@2|Bacteria,COG5635@2|Bacteria,2G8R0@200795|Chloroflexi,3766B@32061|Chloroflexia	32061|Chloroflexia	CDT	Armadillo/beta-catenin-like repeats	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,HEAT_PBS
HKD2_k127_7902270_0	448385.sce5515	3.774e-218	698.0	COG5426@1|root,COG5426@2|Bacteria,1MVWA@1224|Proteobacteria,42ZBA@68525|delta/epsilon subdivisions,2WUF4@28221|Deltaproteobacteria,2YUZP@29|Myxococcales	28221|Deltaproteobacteria	S	Putative glutamine amidotransferase	-	-	-	-	-	-	-	-	-	-	-	-	GATase1_like
HKD2_k127_7902270_4	448385.sce5518	3.469e-84	289.0	COG1657@1|root,COG1657@2|Bacteria,1QX5U@1224|Proteobacteria,42ZX1@68525|delta/epsilon subdivisions,2WVF4@28221|Deltaproteobacteria,2YV56@29|Myxococcales	28221|Deltaproteobacteria	I	Domain of unknown function (DUF4159)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4159
HKD2_k127_7902270_2	1254432.SCE1572_33725	1.074e-163	535.0	COG0248@1|root,COG2206@1|root,COG0248@2|Bacteria,COG2206@2|Bacteria,1MV35@1224|Proteobacteria,42NIH@68525|delta/epsilon subdivisions,2WN60@28221|Deltaproteobacteria,2YUZ0@29|Myxococcales	28221|Deltaproteobacteria	FP	Ppx/GppA phosphatase family	gppA-2	-	3.6.1.11,3.6.1.40	ko:K01524	ko00230,map00230	-	R03409	RC00002	ko00000,ko00001,ko01000	-	-	-	HD,Ppx-GppA
HKD2_k127_7928269_1	1254432.SCE1572_18900	1.305e-61	214.0	COG0052@1|root,COG0052@2|Bacteria,1MU33@1224|Proteobacteria,42M3Y@68525|delta/epsilon subdivisions,2WJH5@28221|Deltaproteobacteria,2YTZQ@29|Myxococcales	28221|Deltaproteobacteria	J	Belongs to the universal ribosomal protein uS2 family	rpsB	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
HKD2_k127_7928269_2	215803.DB30_5488	2.74e-16	89.0	2AYRE@1|root,31QWF@2|Bacteria,1QNFJ@1224|Proteobacteria,43DZP@68525|delta/epsilon subdivisions,2X93E@28221|Deltaproteobacteria,2Z1PQ@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7928269_3	290512.Paes_1869	2.638e-15	81.0	COG0721@1|root,COG0721@2|Bacteria,1FE7M@1090|Chlorobi	1090|Chlorobi	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatC	-	6.3.5.6,6.3.5.7	ko:K02435	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Glu-tRNAGln
HKD2_k127_7928269_0	1254432.SCE1572_25880	1.657e-163	528.0	COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,42MAH@68525|delta/epsilon subdivisions,2WJT7@28221|Deltaproteobacteria,2YTXJ@29|Myxococcales	28221|Deltaproteobacteria	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
HKD2_k127_7938541_0	1254432.SCE1572_12415	4.595e-84	297.0	COG1641@1|root,COG1641@2|Bacteria,1MUKU@1224|Proteobacteria,42MHQ@68525|delta/epsilon subdivisions,2WJAC@28221|Deltaproteobacteria,2YUS7@29|Myxococcales	28221|Deltaproteobacteria	S	Belongs to the LarC family	-	-	4.99.1.12	ko:K09121	-	-	-	-	ko00000,ko01000	-	-	-	DUF111
HKD2_k127_7938541_1	1254432.SCE1572_12410	1.355e-76	278.0	COG1691@1|root,COG1691@2|Bacteria,1REQ7@1224|Proteobacteria,42MJG@68525|delta/epsilon subdivisions,2WN0G@28221|Deltaproteobacteria,2YUU1@29|Myxococcales	28221|Deltaproteobacteria	S	AIR carboxylase	-	-	-	ko:K06898	-	-	-	-	ko00000	-	-	-	AIRC
HKD2_k127_7956484_2	1254432.SCE1572_10990	1.386e-66	243.0	COG1716@1|root,COG2199@1|root,COG1716@2|Bacteria,COG3706@2|Bacteria,1MZV7@1224|Proteobacteria,4302C@68525|delta/epsilon subdivisions,2WVBW@28221|Deltaproteobacteria,2YUSZ@29|Myxococcales	28221|Deltaproteobacteria	T	GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	FHA,GGDEF,Yop-YscD_cpl
HKD2_k127_7956484_1	215803.DB30_5098	2.045e-79	283.0	COG2723@1|root,COG2723@2|Bacteria,1MWG6@1224|Proteobacteria,42UR5@68525|delta/epsilon subdivisions,2WQET@28221|Deltaproteobacteria,2YU27@29|Myxococcales	28221|Deltaproteobacteria	G	Belongs to the glycosyl hydrolase 1 family	-	-	3.2.1.21	ko:K05350	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_1
HKD2_k127_7956484_0	1254432.SCE1572_17640	1.458e-111	366.0	COG1028@1|root,COG1028@2|Bacteria,1MXNQ@1224|Proteobacteria,42Q8V@68525|delta/epsilon subdivisions,2WJP0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	IQ	PFAM Short-chain dehydrogenase reductase SDR	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HKD2_k127_7960189_6	886293.Sinac_2785	4.129e-24	112.0	COG0282@1|root,COG0282@2|Bacteria,2IXZC@203682|Planctomycetes	2|Bacteria	H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction	ackA	-	2.7.2.1	ko:K00925	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00315,R01353	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetate_kinase
HKD2_k127_7960189_0	1144275.COCOR_01450	0.0	1364.0	COG3957@1|root,COG3957@2|Bacteria,1MVSE@1224|Proteobacteria	1224|Proteobacteria	G	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase	-	-	4.1.2.22,4.1.2.9	ko:K01621	ko00030,ko00710,ko01100,ko01120,map00030,map00710,map01100,map01120	-	R00761,R01621	RC00032,RC00226	ko00000,ko00001,ko01000	-	-	-	XFP,XFP_C,XFP_N
HKD2_k127_7960189_8	502025.Hoch_4700	1.878e-11	73.0	COG3809@1|root,COG3809@2|Bacteria,1QJZM@1224|Proteobacteria,43E52@68525|delta/epsilon subdivisions,2X98E@28221|Deltaproteobacteria,2Z2KB@29|Myxococcales	28221|Deltaproteobacteria	S	Transcription factor zinc-finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-TFIIB
HKD2_k127_7960189_7	529884.Rhola_00000490	3.191e-13	76.0	COG0824@1|root,COG0824@2|Bacteria,2IHBJ@201174|Actinobacteria,4FNDN@85023|Microbacteriaceae	201174|Actinobacteria	S	Thioesterase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT_2
HKD2_k127_7960189_2	215803.DB30_5832	7.591e-77	273.0	COG4122@1|root,COG4122@2|Bacteria,1N57D@1224|Proteobacteria,43BAF@68525|delta/epsilon subdivisions,2X6PN@28221|Deltaproteobacteria,2YXWW@29|Myxococcales	28221|Deltaproteobacteria	S	O-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_3
HKD2_k127_7960189_1	1210884.HG799462_gene8794	2.363e-104	362.0	COG4191@1|root,COG4191@2|Bacteria,2J2PC@203682|Planctomycetes	203682|Planctomycetes	T	PAS fold	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_4,Response_reg
HKD2_k127_7960189_5	682795.AciX8_0739	4.198e-52	203.0	COG0402@1|root,COG0402@2|Bacteria	2|Bacteria	F	S-adenosylhomocysteine deaminase activity	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
HKD2_k127_7960189_4	448385.sce7295	9.617e-58	222.0	COG0515@1|root,COG0515@2|Bacteria,1Q2R6@1224|Proteobacteria,433VB@68525|delta/epsilon subdivisions,2X3MY@28221|Deltaproteobacteria,2YWK6@29|Myxococcales	28221|Deltaproteobacteria	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HKD2_k127_7960189_3	1283299.AUKG01000002_gene4034	2.951e-71	250.0	COG0393@1|root,COG0393@2|Bacteria,2I9NA@201174|Actinobacteria	201174|Actinobacteria	S	Belongs to the UPF0145 family	-	-	-	-	-	-	-	-	-	-	-	-	YbjQ_1
HKD2_k127_7960189_9	1183438.GKIL_3494	8.86e-06	48.0	COG0393@1|root,COG0393@2|Bacteria,1GC92@1117|Cyanobacteria	1117|Cyanobacteria	S	Putative heavy-metal-binding	-	-	-	-	-	-	-	-	-	-	-	-	YbjQ_1
HKD2_k127_7964521_0	1192034.CAP_7016	0.0	1170.0	COG0493@1|root,COG0543@1|root,COG0493@2|Bacteria,COG0543@2|Bacteria,1Q2ZJ@1224|Proteobacteria,438P5@68525|delta/epsilon subdivisions,2X8TH@28221|Deltaproteobacteria,2YXE6@29|Myxococcales	28221|Deltaproteobacteria	CEH	Pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2
HKD2_k127_7964521_1	215803.DB30_3360	3.707e-97	352.0	COG2010@1|root,COG2010@2|Bacteria,1Q2X2@1224|Proteobacteria,438K0@68525|delta/epsilon subdivisions,2X3UM@28221|Deltaproteobacteria,2YX56@29|Myxococcales	28221|Deltaproteobacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7974905_0	525904.Tter_0214	4.164e-121	397.0	COG0624@1|root,COG0624@2|Bacteria,2NQM8@2323|unclassified Bacteria	2|Bacteria	E	Peptidase dimerisation domain	dapE	-	3.5.1.16,3.5.1.18	ko:K01436,ko:K01438,ko:K01439	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R00669,R02734,R09107	RC00064,RC00090,RC00300	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20
HKD2_k127_7974905_1	1192034.CAP_4882	3.245e-100	335.0	COG1989@1|root,COG1989@2|Bacteria,1MUZF@1224|Proteobacteria,42S2A@68525|delta/epsilon subdivisions,2WMQ8@28221|Deltaproteobacteria,2YVME@29|Myxococcales	28221|Deltaproteobacteria	NOU	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue	pilD	-	3.4.23.43	ko:K02654	-	M00331	-	-	ko00000,ko00002,ko01000,ko01002,ko02035,ko02044	3.A.15.2	-	-	DiS_P_DiS,Peptidase_A24
HKD2_k127_7974905_2	1254432.SCE1572_52675	2.778e-79	269.0	COG0009@1|root,COG0009@2|Bacteria,1MVPM@1224|Proteobacteria,42QSV@68525|delta/epsilon subdivisions,2WMZ5@28221|Deltaproteobacteria,2YVAC@29|Myxococcales	28221|Deltaproteobacteria	J	Belongs to the SUA5 family	yrdC	-	2.7.7.87	ko:K07566	-	-	R10463	RC00745	ko00000,ko01000,ko03009,ko03016	-	-	-	Sua5_yciO_yrdC
HKD2_k127_7974905_4	105420.BBPO01000005_gene2804	6.442e-45	177.0	COG1502@1|root,COG3227@1|root,COG1502@2|Bacteria,COG3227@2|Bacteria,2HA2M@201174|Actinobacteria,2NEGY@228398|Streptacidiphilus	201174|Actinobacteria	EI	PLD-like domain	-	-	-	-	-	-	-	-	-	-	-	-	He_PIG,PLDc_2
HKD2_k127_7974905_6	502025.Hoch_0348	6.039e-42	174.0	COG1621@1|root,COG1621@2|Bacteria,1RCMP@1224|Proteobacteria,432Y7@68525|delta/epsilon subdivisions	1224|Proteobacteria	G	beta-fructofuranosidase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7974905_5	1479238.JQMZ01000001_gene745	1.715e-42	167.0	COG0351@1|root,COG0351@2|Bacteria,1MU9J@1224|Proteobacteria,2TUKR@28211|Alphaproteobacteria,43XA3@69657|Hyphomonadaceae	28211|Alphaproteobacteria	H	Phosphomethylpyrimidine kinase	thiD	-	2.7.1.49,2.7.4.7	ko:K00941	ko00730,ko01100,map00730,map01100	M00127	R03471,R04509	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyoxalase,Phos_pyr_kin
HKD2_k127_7974905_3	211114.JOEF01000033_gene1152	2.617e-72	271.0	COG3459@1|root,COG3459@2|Bacteria,2HQFF@201174|Actinobacteria,4E98C@85010|Pseudonocardiales	201174|Actinobacteria	G	Glycosyl hydrolase 36 superfamily, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_36
HKD2_k127_7976611_0	448385.sce5791	1.845e-120	393.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2YTW0@29|Myxococcales	28221|Deltaproteobacteria	T	response regulator	-	-	-	ko:K02481,ko:K07713	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD2_k127_7976611_1	1192034.CAP_7335	2.637e-117	404.0	COG1187@1|root,COG2885@1|root,COG1187@2|Bacteria,COG2885@2|Bacteria,1MWHF@1224|Proteobacteria,42SM6@68525|delta/epsilon subdivisions,2X3B1@28221|Deltaproteobacteria,2YV6X@29|Myxococcales	28221|Deltaproteobacteria	M	OmpA family	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,OmpA
HKD2_k127_7976611_6	448385.sce0136	0.0002904	53.0	COG3391@1|root,COG3391@2|Bacteria,1Q2JN@1224|Proteobacteria,4386H@68525|delta/epsilon subdivisions,2X9ZH@28221|Deltaproteobacteria,2YVZH@29|Myxococcales	28221|Deltaproteobacteria	S	Beta-L-arabinofuranosidase, GH127	-	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3,Stig1
HKD2_k127_7976611_4	926560.KE387027_gene299	4.365e-43	166.0	COG0652@1|root,COG0652@2|Bacteria,1WIFK@1297|Deinococcus-Thermus	2|Bacteria	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	-	-	5.2.1.8	ko:K01802,ko:K03768	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Pro_isomerase
HKD2_k127_7976611_3	1122132.AQYH01000010_gene4262	1.985e-52	194.0	COG2761@1|root,COG2761@2|Bacteria,1NXUB@1224|Proteobacteria,2TRJ6@28211|Alphaproteobacteria,4BAJC@82115|Rhizobiaceae	28211|Alphaproteobacteria	Q	DSBA-like thioredoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	DSBA
HKD2_k127_7976611_5	1254432.SCE1572_34455	4.782e-37	147.0	COG0779@1|root,COG0779@2|Bacteria,1RDP2@1224|Proteobacteria,42THF@68525|delta/epsilon subdivisions,2WQ0W@28221|Deltaproteobacteria,2Z300@29|Myxococcales	28221|Deltaproteobacteria	J	Required for maturation of 30S ribosomal subunits	rimP	-	-	ko:K09748	-	-	-	-	ko00000,ko03009	-	-	-	DUF150,DUF150_C
HKD2_k127_7976611_2	1192034.CAP_7326	2.449e-96	331.0	COG0195@1|root,COG0195@2|Bacteria,1MWT7@1224|Proteobacteria,42MUW@68525|delta/epsilon subdivisions,2WIXI@28221|Deltaproteobacteria,2YUJG@29|Myxococcales	28221|Deltaproteobacteria	K	Participates in both transcription termination and antitermination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	HHH_5,KH_5,NusA_N,S1
HKD2_k127_7986420_0	1192034.CAP_0853	2.371e-128	444.0	COG0457@1|root,COG2204@1|root,COG0457@2|Bacteria,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2YY1G@29|Myxococcales	28221|Deltaproteobacteria	K	Sigma-54 interaction domain	-	-	-	ko:K10941	ko02020,ko02025,ko05111,map02020,map02025,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_8,Sigma54_activat,TPR_12
HKD2_k127_7986420_2	1192034.CAP_0854	7.617e-77	266.0	COG5495@1|root,COG5495@2|Bacteria,1RDUW@1224|Proteobacteria,43799@68525|delta/epsilon subdivisions,2X2CQ@28221|Deltaproteobacteria,2YVZN@29|Myxococcales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF2520)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2520,Rossmann-like
HKD2_k127_7986420_4	391625.PPSIR1_12098	1.674e-24	116.0	COG1057@1|root,COG5495@1|root,COG1057@2|Bacteria,COG5495@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF2520)	nadD	GO:0000309,GO:0003674,GO:0003824,GO:0004515,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019365,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0034355,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0040007,GO:0043094,GO:0043173,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	2.7.1.22,2.7.7.1,2.7.7.18,3.5.4.4,3.6.1.55	ko:K00969,ko:K01488,ko:K03574,ko:K06211	ko00230,ko00760,ko01100,ko05340,map00230,map00760,map01100,map05340	M00115	R00137,R01560,R02324,R02556,R03005	RC00002,RC00017,RC00477	ko00000,ko00001,ko00002,ko01000,ko03000,ko03400	-	-	iAF987.Gmet_3200,iECUMN_1333.ECUMN_0733,iIT341.HP1337,iJN746.PP_4810,iPC815.YPO2607,iSbBS512_1146.SbBS512_E0612	CTP_transf_like,DUF2520,Rossmann-like
HKD2_k127_7986420_1	1254432.SCE1572_14775	1.252e-97	333.0	COG0446@1|root,COG0446@2|Bacteria,1MVEK@1224|Proteobacteria,42XU1@68525|delta/epsilon subdivisions,2WSV4@28221|Deltaproteobacteria,2YUYW@29|Myxococcales	28221|Deltaproteobacteria	C	2Fe-2S iron-sulfur cluster binding domain	-	-	1.5.3.1	ko:K00302	ko00260,ko01100,map00260,map01100	-	R00610	RC00060,RC00557	ko00000,ko00001,ko01000	-	-	-	Fer2_4,NAD_binding_8,Pyr_redox_2
HKD2_k127_7987383_3	483219.LILAB_20720	2.697e-76	258.0	COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,42M4I@68525|delta/epsilon subdivisions,2WJHM@28221|Deltaproteobacteria,2YUJ6@29|Myxococcales	28221|Deltaproteobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
HKD2_k127_7987383_4	685035.ADAE01000008_gene3002	1.901e-68	242.0	COG0106@1|root,COG0106@2|Bacteria,1MW6S@1224|Proteobacteria,2TRSG@28211|Alphaproteobacteria,2K0CJ@204457|Sphingomonadales	204457|Sphingomonadales	E	1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase	hisA	-	5.3.1.16	ko:K01814	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04640	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
HKD2_k127_7987383_6	1121472.AQWN01000002_gene2274	3.473e-48	185.0	COG0118@1|root,COG0118@2|Bacteria,1TQT0@1239|Firmicutes,248SH@186801|Clostridia,260M0@186807|Peptococcaceae	186801|Clostridia	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR	hisH	-	-	ko:K02501	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
HKD2_k127_7987383_2	1192034.CAP_6760	4.53e-99	334.0	COG0548@1|root,COG0548@2|Bacteria,1MU17@1224|Proteobacteria,42N8G@68525|delta/epsilon subdivisions,2WKBC@28221|Deltaproteobacteria,2YUS2@29|Myxococcales	28221|Deltaproteobacteria	F	Belongs to the acetylglutamate kinase family. ArgB subfamily	argB	GO:0003674,GO:0003824,GO:0003991,GO:0005488,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0019752,GO:0031406,GO:0034618,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.2.8	ko:K00930	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R02649	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase
HKD2_k127_7987383_0	404589.Anae109_0180	6.665e-148	476.0	COG0002@1|root,COG0002@2|Bacteria,1MVJ6@1224|Proteobacteria,42MDN@68525|delta/epsilon subdivisions,2WINX@28221|Deltaproteobacteria,2YTTI@29|Myxococcales	28221|Deltaproteobacteria	E	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde	argC	-	1.2.1.38	ko:K00145	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R03443	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
HKD2_k127_7987383_1	1242864.D187_004846	1.396e-136	444.0	COG0624@1|root,COG0624@2|Bacteria,1MUSU@1224|Proteobacteria,42NNZ@68525|delta/epsilon subdivisions,2WJ7C@28221|Deltaproteobacteria,2YUD7@29|Myxococcales	28221|Deltaproteobacteria	E	Peptidase dimerisation domain	-	-	3.4.17.11	ko:K01295	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
HKD2_k127_7987383_5	1192034.CAP_8147	1.778e-50	206.0	COG0613@1|root,COG0613@2|Bacteria,1R4N5@1224|Proteobacteria	1224|Proteobacteria	S	PHP domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7996754_2	326427.Cagg_1838	2.299e-21	96.0	COG0169@1|root,COG0169@2|Bacteria,2G6FG@200795|Chloroflexi,375I6@32061|Chloroflexia	32061|Chloroflexia	E	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)	aroE	-	1.1.1.25	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413	RC00206	ko00000,ko00001,ko00002,ko01000	-	-	-	Shikimate_DH,Shikimate_dh_N
HKD2_k127_7996754_0	1254432.SCE1572_14875	3.059e-102	358.0	COG1570@1|root,COG1570@2|Bacteria,1MUA4@1224|Proteobacteria,42MSB@68525|delta/epsilon subdivisions,2WJI6@28221|Deltaproteobacteria,2YV21@29|Myxococcales	28221|Deltaproteobacteria	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseA	-	3.1.11.6	ko:K03601	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_L,tRNA_anti_2
HKD2_k127_7996754_1	1192034.CAP_5518	2.127e-63	233.0	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,42NF6@68525|delta/epsilon subdivisions,2WKVH@28221|Deltaproteobacteria,2YUUC@29|Myxococcales	28221|Deltaproteobacteria	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD2_k127_8012880_0	448385.sce5945	3.34e-236	754.0	COG0457@1|root,COG0457@2|Bacteria,1Q2EC@1224|Proteobacteria,43804@68525|delta/epsilon subdivisions,2X3A2@28221|Deltaproteobacteria,2YV2B@29|Myxococcales	28221|Deltaproteobacteria	D	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_6
HKD2_k127_8012880_1	448385.sce5944	7.495e-162	525.0	COG0457@1|root,COG1729@1|root,COG0457@2|Bacteria,COG1729@2|Bacteria,1MX82@1224|Proteobacteria,42TQ9@68525|delta/epsilon subdivisions,2WR3B@28221|Deltaproteobacteria,2YUCZ@29|Myxococcales	28221|Deltaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_6
HKD2_k127_8013987_0	1197130.BAFM01000001_gene34	8.059e-42	172.0	COG1501@1|root,arCOG03663@2157|Archaea,2XV49@28890|Euryarchaeota,23V0G@183963|Halobacteria	183963|Halobacteria	G	Melibiase	-	-	3.2.1.22	ko:K07407	ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603	-	R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05549,R05961,R06091	RC00049,RC00059,RC00451	ko00000,ko00001,ko01000	-	-	-	Melibiase
HKD2_k127_8018110_0	1242864.D187_002248	2.775e-81	293.0	COG3831@1|root,COG3831@2|Bacteria,1QWC3@1224|Proteobacteria	1224|Proteobacteria	S	Domain of unknown function (DUF4132)	JD73_20480	-	-	-	-	-	-	-	-	-	-	-	DUF4132,WGR
HKD2_k127_8021368_1	1131269.AQVV01000002_gene1176	1.077e-85	308.0	COG0342@1|root,COG0342@2|Bacteria	2|Bacteria	U	P-P-bond-hydrolysis-driven protein transmembrane transporter activity	secD	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944	-	ko:K03072,ko:K12257	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
HKD2_k127_8021368_4	1112216.JH594425_gene3665	3.051e-06	55.0	COG1862@1|root,COG1862@2|Bacteria,1MZT2@1224|Proteobacteria,2UBZ6@28211|Alphaproteobacteria,2K62B@204457|Sphingomonadales	204457|Sphingomonadales	U	Preprotein translocase subunit YajC	yajC	-	-	ko:K03210	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	YajC
HKD2_k127_8021368_2	1278073.MYSTI_00138	1.03e-75	264.0	COG0330@1|root,COG0330@2|Bacteria,1MUM8@1224|Proteobacteria,42NX0@68525|delta/epsilon subdivisions,2WISZ@28221|Deltaproteobacteria,2YZ16@29|Myxococcales	28221|Deltaproteobacteria	O	prohibitin homologues	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
HKD2_k127_8021368_3	1254432.SCE1572_33325	3.441e-37	153.0	COG0515@1|root,COG1262@1|root,COG0515@2|Bacteria,COG1262@2|Bacteria,1MZ25@1224|Proteobacteria,42PUT@68525|delta/epsilon subdivisions,2WKN0@28221|Deltaproteobacteria,2YVT8@29|Myxococcales	28221|Deltaproteobacteria	KLT	Sulfatase-modifying factor enzyme 1	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	FGE-sulfatase,Pkinase
HKD2_k127_8021368_0	448385.sce2882	2.735e-144	462.0	COG1875@1|root,COG1875@2|Bacteria,1MUX1@1224|Proteobacteria,42MK9@68525|delta/epsilon subdivisions,2WJ1C@28221|Deltaproteobacteria,2YY78@29|Myxococcales	28221|Deltaproteobacteria	T	Large family of predicted nucleotide-binding domains	phoH1	-	-	ko:K07175	-	-	-	-	ko00000	-	-	-	PIN_4,PhoH
HKD2_k127_8027349_4	448385.sce3144	5.447e-106	349.0	COG1192@1|root,COG1192@2|Bacteria,1MV43@1224|Proteobacteria,42MTF@68525|delta/epsilon subdivisions,2WJ6X@28221|Deltaproteobacteria,2YTSA@29|Myxococcales	28221|Deltaproteobacteria	D	NUBPL iron-transfer P-loop NTPase	soj	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
HKD2_k127_8027349_5	1192034.CAP_8966	8.7e-98	329.0	COG1475@1|root,COG1475@2|Bacteria,1MW2E@1224|Proteobacteria,42M8S@68525|delta/epsilon subdivisions,2WNG8@28221|Deltaproteobacteria,2YV3C@29|Myxococcales	28221|Deltaproteobacteria	K	Belongs to the ParB family	parB	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
HKD2_k127_8027349_7	1005048.CFU_0375	4.893e-32	133.0	COG3064@1|root,COG3064@2|Bacteria,1N9GV@1224|Proteobacteria,2W0MW@28216|Betaproteobacteria	28216|Betaproteobacteria	M	YXWGXW repeat (2 copies)	-	-	-	-	-	-	-	-	-	-	-	-	YXWGXW
HKD2_k127_8027349_3	1192034.CAP_6873	1.365e-120	393.0	COG0190@1|root,COG0190@2|Bacteria,1MWU4@1224|Proteobacteria,42MW0@68525|delta/epsilon subdivisions,2WJ90@28221|Deltaproteobacteria,2YTZN@29|Myxococcales	28221|Deltaproteobacteria	F	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate	folD	GO:0003674,GO:0003824,GO:0004477,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0019238,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114	1.5.1.5,3.5.4.9	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R01220,R01655	RC00202,RC00578	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_1162	THF_DHG_CYH,THF_DHG_CYH_C
HKD2_k127_8027349_2	1254432.SCE1572_23450	2.014e-142	459.0	COG0682@1|root,COG0682@2|Bacteria,1MVE3@1224|Proteobacteria,42M2I@68525|delta/epsilon subdivisions,2WNPT@28221|Deltaproteobacteria,2YVDG@29|Myxococcales	28221|Deltaproteobacteria	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	lgt	-	-	ko:K13292	-	-	-	-	ko00000,ko01000	-	-	-	LGT
HKD2_k127_8027349_6	1254432.SCE1572_23460	1.714e-51	191.0	COG0597@1|root,COG0597@2|Bacteria,1RGV9@1224|Proteobacteria,42UAT@68525|delta/epsilon subdivisions,2WQ31@28221|Deltaproteobacteria,2Z252@29|Myxococcales	28221|Deltaproteobacteria	MU	This protein specifically catalyzes the removal of signal peptides from prolipoproteins	lspA	-	3.4.23.36	ko:K03101	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_A8
HKD2_k127_8027349_0	448385.sce3906	6.269e-311	971.0	COG1111@1|root,COG1205@1|root,COG1111@2|Bacteria,COG1205@2|Bacteria,1QU0I@1224|Proteobacteria,42M4R@68525|delta/epsilon subdivisions,2WK1V@28221|Deltaproteobacteria,2YUHN@29|Myxococcales	28221|Deltaproteobacteria	L	Domain of unknown function (DUF1998)	yprA	-	-	ko:K06877	-	-	-	-	ko00000	-	-	-	DEAD,DUF1998,Helicase_C,RNase_H_2
HKD2_k127_8027349_8	1123400.KB904765_gene1396	6.297e-10	73.0	COG0823@1|root,COG1361@1|root,COG2706@1|root,COG2834@1|root,COG3291@1|root,COG5384@1|root,COG0823@2|Bacteria,COG1361@2|Bacteria,COG2706@2|Bacteria,COG2834@2|Bacteria,COG3291@2|Bacteria,COG5384@2|Bacteria,1QUSE@1224|Proteobacteria	1224|Proteobacteria	G	PFAM FecR protein	-	-	3.2.1.4	ko:K01179,ko:K03933	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	AA10,CBM73,GH5,GH9	-	CBM_2,Calx-beta,Cellulase,PKD
HKD2_k127_8027349_1	448385.sce3724	1.483e-252	790.0	COG0188@1|root,COG0188@2|Bacteria,1MUGG@1224|Proteobacteria,42KZ9@68525|delta/epsilon subdivisions,2WJBC@28221|Deltaproteobacteria,2YUDT@29|Myxococcales	28221|Deltaproteobacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
HKD2_k127_8027707_2	391625.PPSIR1_23234	1.83e-37	146.0	COG2304@1|root,COG2304@2|Bacteria,1Q2PD@1224|Proteobacteria,438AP@68525|delta/epsilon subdivisions,2X3K0@28221|Deltaproteobacteria,2YWD7@29|Myxococcales	28221|Deltaproteobacteria	S	protein containing a von Willebrand factor type A (vWA) domain	-	-	-	-	-	-	-	-	-	-	-	-	VWA,VWA_2
HKD2_k127_8027707_1	1278073.MYSTI_03333	4.098e-40	160.0	COG0204@1|root,COG0204@2|Bacteria,1PZS9@1224|Proteobacteria,434JR@68525|delta/epsilon subdivisions,2WYX1@28221|Deltaproteobacteria,2Z0U7@29|Myxococcales	28221|Deltaproteobacteria	I	Phosphate acyltransferases	-	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
HKD2_k127_8027707_0	1297863.APJF01000001_gene1945	5.784e-89	300.0	COG0500@1|root,COG2226@2|Bacteria,1NWX3@1224|Proteobacteria,2TURQ@28211|Alphaproteobacteria,3JUR1@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
HKD2_k127_8027707_4	2002.JOEQ01000009_gene6511	1.313e-11	74.0	2A1YE@1|root,30Q7Y@2|Bacteria,2H4EQ@201174|Actinobacteria,4ENTM@85012|Streptosporangiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8038995_3	1192034.CAP_5373	6.691e-66	229.0	COG1058@1|root,COG1546@1|root,COG1058@2|Bacteria,COG1546@2|Bacteria,1RH2Y@1224|Proteobacteria,42MQ4@68525|delta/epsilon subdivisions,2WMDT@28221|Deltaproteobacteria,2YUQX@29|Myxococcales	28221|Deltaproteobacteria	S	Belongs to the CinA family	cinA	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363	3.5.1.42	ko:K03742,ko:K03743	ko00760,map00760	-	R02322	RC00100	ko00000,ko00001,ko01000	-	-	-	CinA,MoCF_biosynth
HKD2_k127_8038995_6	448385.sce8169	8.766e-45	183.0	COG1262@1|root,COG1262@2|Bacteria	2|Bacteria	T	PFAM Formylglycine-generating sulfatase enzyme	-	-	1.14.99.50,2.7.11.1	ko:K08884,ko:K12132,ko:K18912	ko00340,map00340	-	R11013	RC03323,RC03324	ko00000,ko00001,ko01000,ko01001	-	-	-	FGE-sulfatase,Pkinase
HKD2_k127_8038995_1	1254432.SCE1572_17530	2.469e-91	306.0	COG0179@1|root,COG0179@2|Bacteria,1MUPF@1224|Proteobacteria,42S98@68525|delta/epsilon subdivisions,2X5D7@28221|Deltaproteobacteria	28221|Deltaproteobacteria	Q	PFAM fumarylacetoacetate (FAA) hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	DUF2437,FAA_hydrolase
HKD2_k127_8038995_5	861299.J421_0447	3.092e-61	221.0	COG2107@1|root,COG2107@2|Bacteria,1ZTVU@142182|Gemmatimonadetes	142182|Gemmatimonadetes	H	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)	mqnD	-	-	ko:K11785	ko00130,ko01110,map00130,map01110	-	R08589	RC02330	ko00000,ko00001,ko01000	-	-	-	VitK2_biosynth
HKD2_k127_8038995_8	1254432.SCE1572_48475	1.008e-24	118.0	COG3591@1|root,COG3591@2|Bacteria	2|Bacteria	E	Belongs to the peptidase S1B family	-	-	-	-	-	-	-	-	-	-	-	-	Trypsin
HKD2_k127_8038995_7	290397.Adeh_2240	2.517e-40	166.0	COG4191@1|root,COG4191@2|Bacteria,1QUMH@1224|Proteobacteria,42MM2@68525|delta/epsilon subdivisions,2X7N8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
HKD2_k127_8038995_0	290397.Adeh_1450	2.428e-142	464.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD2_k127_8038995_4	448385.sce8314	2.515e-65	250.0	COG0614@1|root,COG0614@2|Bacteria,1MWVF@1224|Proteobacteria,42PQA@68525|delta/epsilon subdivisions,2WKNZ@28221|Deltaproteobacteria,2YVK6@29|Myxococcales	28221|Deltaproteobacteria	P	Periplasmic binding protein	-	-	-	ko:K02016	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	Peripla_BP_2
HKD2_k127_8038995_10	290397.Adeh_2592	9.532e-18	95.0	COG3419@1|root,COG5184@1|root,COG3419@2|Bacteria,COG5184@2|Bacteria,1P1C6@1224|Proteobacteria,4310A@68525|delta/epsilon subdivisions,2WWWF@28221|Deltaproteobacteria,2Z029@29|Myxococcales	28221|Deltaproteobacteria	DZ	Putative metal-binding motif	-	-	-	-	-	-	-	-	-	-	-	-	Cu-binding_MopE
HKD2_k127_8038995_9	290397.Adeh_2592	2.192e-21	106.0	COG3419@1|root,COG5184@1|root,COG3419@2|Bacteria,COG5184@2|Bacteria,1P1C6@1224|Proteobacteria,4310A@68525|delta/epsilon subdivisions,2WWWF@28221|Deltaproteobacteria,2Z029@29|Myxococcales	28221|Deltaproteobacteria	DZ	Putative metal-binding motif	-	-	-	-	-	-	-	-	-	-	-	-	Cu-binding_MopE
HKD2_k127_8038995_2	483219.LILAB_31150	2.86e-81	278.0	COG1189@1|root,COG1189@2|Bacteria,1MWP5@1224|Proteobacteria,42R2J@68525|delta/epsilon subdivisions,2WIJ6@28221|Deltaproteobacteria,2YV01@29|Myxococcales	28221|Deltaproteobacteria	J	FtsJ-like methyltransferase	tlyA	-	2.1.1.226,2.1.1.227	ko:K06442	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ,S4
HKD2_k127_8060659_0	448385.sce2920	2.268e-218	693.0	COG0457@1|root,COG2956@1|root,COG0457@2|Bacteria,COG2956@2|Bacteria,1MVIW@1224|Proteobacteria,437VP@68525|delta/epsilon subdivisions,2WWNT@28221|Deltaproteobacteria,2YUC4@29|Myxococcales	28221|Deltaproteobacteria	G	repeat protein	agmK	-	-	-	-	-	-	-	-	-	-	-	TPR_19,TPR_6,TPR_7,TPR_8
HKD2_k127_8061640_2	1450525.JATV01000011_gene1375	7.453e-89	299.0	COG0226@1|root,COG0226@2|Bacteria,4NJGR@976|Bacteroidetes,1I2BC@117743|Flavobacteriia,2NTPT@237|Flavobacterium	976|Bacteroidetes	P	PBP superfamily domain	pstS	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
HKD2_k127_8061640_1	215803.DB30_0087	1.164e-91	322.0	COG0573@1|root,COG0573@2|Bacteria,1MVKP@1224|Proteobacteria,42N2N@68525|delta/epsilon subdivisions,2WJJ1@28221|Deltaproteobacteria,2YV6J@29|Myxococcales	28221|Deltaproteobacteria	P	probably responsible for the translocation of the substrate across the membrane	pstC	-	-	ko:K02037	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
HKD2_k127_8061640_0	1144275.COCOR_02608	1.186e-110	383.0	COG0581@1|root,COG0581@2|Bacteria,1MUWB@1224|Proteobacteria,42MWK@68525|delta/epsilon subdivisions,2WJKH@28221|Deltaproteobacteria,2YVAR@29|Myxococcales	28221|Deltaproteobacteria	P	Phosphate transport system permease	pstA	-	-	ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1,DUF3333
HKD2_k127_8061640_4	1242864.D187_004633	6.057e-45	183.0	COG0704@1|root,COG0704@2|Bacteria,1MUMI@1224|Proteobacteria,42QWG@68525|delta/epsilon subdivisions,2WMS0@28221|Deltaproteobacteria,2YV5C@29|Myxococcales	28221|Deltaproteobacteria	P	Plays a role in the regulation of phosphate uptake	phoU	-	-	ko:K02039	-	-	-	-	ko00000	-	-	-	PhoU
HKD2_k127_8061640_3	1192034.CAP_6867	3.566e-76	263.0	COG0823@1|root,COG0823@2|Bacteria,1RI0N@1224|Proteobacteria	1224|Proteobacteria	U	PA14 domain	-	-	-	-	-	-	-	-	-	-	-	-	PA14,VPEP
HKD2_k127_8061640_5	1463920.JOGB01000012_gene6634	7.102e-07	58.0	2CDI5@1|root,2Z7ZQ@2|Bacteria,2I8FG@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8063377_3	298386.PBPRB1034	1.454e-18	100.0	COG1331@1|root,COG1331@2|Bacteria,1R6MC@1224|Proteobacteria,1S0AF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	Highly conserved protein containing a thioredoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8063377_0	235909.GK2866	2.032e-67	262.0	COG1858@1|root,COG3391@1|root,COG1858@2|Bacteria,COG3391@2|Bacteria,1V255@1239|Firmicutes,4HEF2@91061|Bacilli,1WE34@129337|Geobacillus	91061|Bacilli	C	Di-haem oxidoreductase, putative peroxidase	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_D1,DHOR,Lactonase
HKD2_k127_8063377_1	1144275.COCOR_07886	9.834e-36	151.0	COG1633@1|root,COG1633@2|Bacteria,1P131@1224|Proteobacteria	1224|Proteobacteria	S	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8063377_4	1207055.C100_00235	6.775e-05	53.0	COG2010@1|root,COG2010@2|Bacteria,1N7I9@1224|Proteobacteria,2V1R3@28211|Alphaproteobacteria,2KBX4@204457|Sphingomonadales	204457|Sphingomonadales	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8063377_2	1254432.SCE1572_33745	8.426e-21	104.0	COG1470@1|root,COG1470@2|Bacteria,1P6QQ@1224|Proteobacteria,4385T@68525|delta/epsilon subdivisions,2X3FM@28221|Deltaproteobacteria,2YVWE@29|Myxococcales	28221|Deltaproteobacteria	S	cell adhesion involved in biofilm formation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8068916_3	644801.Psest_0562	2.853e-47	183.0	COG0392@1|root,COG0474@1|root,COG0392@2|Bacteria,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,1RMYC@1236|Gammaproteobacteria,1Z41J@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	P	Cation transporter/ATPase, N-terminus	-	-	3.6.3.2	ko:K01531,ko:K12955	-	-	-	-	ko00000,ko01000	3.A.3.24,3.A.3.4	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3,LPG_synthase_TM
HKD2_k127_8068916_2	240292.Ava_4090	1.532e-49	186.0	COG1278@1|root,COG1278@2|Bacteria,1G5DM@1117|Cyanobacteria,1HMJV@1161|Nostocales	1117|Cyanobacteria	K	'Cold-shock' DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	CSD,Ribosomal_S30AE
HKD2_k127_8068916_5	1254432.SCE1572_48605	1.133e-21	110.0	COG1131@1|root,COG1131@2|Bacteria	2|Bacteria	V	ATPase activity	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	-
HKD2_k127_8068916_0	1254432.SCE1572_48560	6.716e-125	419.0	COG0263@1|root,COG0263@2|Bacteria,1MUBG@1224|Proteobacteria,42NEA@68525|delta/epsilon subdivisions,2WIVS@28221|Deltaproteobacteria,2YTY2@29|Myxococcales	28221|Deltaproteobacteria	F	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate	proB	GO:0003674,GO:0003824,GO:0004349,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0018130,GO:0019202,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.2.11	ko:K00931	ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230	M00015	R00239	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_3198	AA_kinase,PUA
HKD2_k127_8068916_1	502025.Hoch_3713	1.182e-82	302.0	COG0823@1|root,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	Big_3_2,CARDB,F5_F8_type_C,FlgD_ig,PD40,Prenyltrans
HKD2_k127_8080249_1	448385.sce9100	1.73e-23	115.0	COG1262@1|root,COG1404@1|root,COG2931@1|root,COG1262@2|Bacteria,COG1404@2|Bacteria,COG2931@2|Bacteria,1QADC@1224|Proteobacteria,43504@68525|delta/epsilon subdivisions,2X3M0@28221|Deltaproteobacteria,2YWGK@29|Myxococcales	28221|Deltaproteobacteria	O	GON domain	-	-	-	-	-	-	-	-	-	-	-	-	GON
HKD2_k127_8080249_2	298655.KI912266_gene5342	9.091e-15	87.0	COG0726@1|root,COG0726@2|Bacteria,2GN6G@201174|Actinobacteria,4ET5A@85013|Frankiales	201174|Actinobacteria	G	polysaccharide deacetylase	-	-	3.5.1.104	ko:K22278	-	-	-	-	ko00000,ko01000	-	-	-	Polysacc_deac_1
HKD2_k127_8080249_0	366602.Caul_4146	1.076e-51	198.0	COG2267@1|root,COG2267@2|Bacteria,1QDFI@1224|Proteobacteria,2U244@28211|Alphaproteobacteria,2KIAB@204458|Caulobacterales	204458|Caulobacterales	I	Protein of unknown function (DUF3089)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3089
HKD2_k127_8083556_3	448385.sce4512	6.541e-59	217.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,42MVV@68525|delta/epsilon subdivisions,2X4JB@28221|Deltaproteobacteria,2YZ4I@29|Myxococcales	28221|Deltaproteobacteria	KLT	Family membership	-	-	2.7.11.1	ko:K08884	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HKD2_k127_8083556_6	1254432.SCE1572_14920	2.115e-30	139.0	COG0457@1|root,COG0457@2|Bacteria	1254432.SCE1572_14920|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8083556_1	448385.sce2156	9.087e-75	270.0	COG2220@1|root,COG2220@2|Bacteria,1MV20@1224|Proteobacteria,42PI0@68525|delta/epsilon subdivisions,2WJ79@28221|Deltaproteobacteria,2YUU7@29|Myxococcales	28221|Deltaproteobacteria	S	Zn-dependent hydrolases of the beta-lactamase fold	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
HKD2_k127_8083556_2	1192034.CAP_6834	1.842e-70	254.0	COG1028@1|root,COG1028@2|Bacteria	1192034.CAP_6834|-	IQ	oxidoreductase activity, acting on CH-OH group of donors	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8083556_0	1192034.CAP_6832	1.45e-109	366.0	2DMMW@1|root,32SIJ@2|Bacteria,1N004@1224|Proteobacteria,42TSJ@68525|delta/epsilon subdivisions,2WQHG@28221|Deltaproteobacteria,2YV84@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8083556_4	1192034.CAP_6831	1.301e-35	138.0	COG4260@1|root,COG4260@2|Bacteria,1MXTD@1224|Proteobacteria,42P7D@68525|delta/epsilon subdivisions,2WJ6S@28221|Deltaproteobacteria,2YUUH@29|Myxococcales	28221|Deltaproteobacteria	S	SPFH domain-Band 7 family	-	-	-	-	-	-	-	-	-	-	-	-	Band_7_1,DUF4339,DZR,SHOCT,zinc_ribbon_2
HKD2_k127_8100682_3	596323.HMPREF0554_0534	1.723e-10	72.0	COG1538@1|root,COG1538@2|Bacteria,378ET@32066|Fusobacteria	32066|Fusobacteria	MU	outer membrane efflux protein	-	-	-	ko:K03287	-	-	-	-	ko00000	1.B.17	-	-	OEP
HKD2_k127_8100682_2	1242864.D187_008772	1.187e-20	103.0	COG1309@1|root,COG1309@2|Bacteria,1N6R3@1224|Proteobacteria,42N4M@68525|delta/epsilon subdivisions	1224|Proteobacteria	K	regulatory protein TetR	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N,WHG
HKD2_k127_8100682_0	215803.DB30_6918	9.177e-178	582.0	COG0477@1|root,COG0477@2|Bacteria,1RGPN@1224|Proteobacteria,43BMI@68525|delta/epsilon subdivisions,2X6ZQ@28221|Deltaproteobacteria,2Z3FD@29|Myxococcales	28221|Deltaproteobacteria	P	Major Facilitator Superfamily	-	-	-	ko:K03446	-	M00701	-	-	ko00000,ko00002,ko02000	2.A.1.3	-	-	MFS_1
HKD2_k127_8100682_1	215803.DB30_6919	1.294e-84	293.0	COG1566@1|root,COG1566@2|Bacteria,1MU7I@1224|Proteobacteria,42S77@68525|delta/epsilon subdivisions,2X5PF@28221|Deltaproteobacteria,2YXJB@29|Myxococcales	28221|Deltaproteobacteria	V	Biotin-lipoyl like	-	-	-	ko:K03543	-	M00701	-	-	ko00000,ko00002,ko02000	8.A.1.1	-	-	Biotin_lipoyl_2,HlyD_D23
HKD2_k127_8106591_0	1254432.SCE1572_00110	1.376e-68	248.0	COG0815@1|root,COG0815@2|Bacteria,1MUBU@1224|Proteobacteria,42MPS@68525|delta/epsilon subdivisions,2WIUD@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Transfers the fatty acyl group on membrane lipoproteins	lnt	-	-	ko:K03820	-	-	-	-	ko00000,ko01000	-	GT2	-	CN_hydrolase
HKD2_k127_8108426_0	378806.STAUR_4337	1.931e-64	233.0	COG2133@1|root,COG2133@2|Bacteria,1PEHH@1224|Proteobacteria,437W5@68525|delta/epsilon subdivisions,2X35P@28221|Deltaproteobacteria,2YUDG@29|Myxococcales	28221|Deltaproteobacteria	G	pyrroloquinoline quinone binding	-	-	-	-	-	-	-	-	-	-	-	-	GSDH
HKD2_k127_8108426_1	1227495.C487_11267	6.617e-34	137.0	COG1719@1|root,arCOG01688@2157|Archaea,2Y381@28890|Euryarchaeota,23Z5Y@183963|Halobacteria	183963|Halobacteria	S	Heme NO binding	-	-	-	-	-	-	-	-	-	-	-	-	HNOB
HKD2_k127_8112651_6	1297742.A176_05280	1.002e-69	259.0	COG0308@1|root,COG0308@2|Bacteria,1P5AT@1224|Proteobacteria	1224|Proteobacteria	E	Peptidase family M1 domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M1
HKD2_k127_8112651_12	1123229.AUBC01000032_gene3758	1.34e-25	120.0	COG0671@1|root,COG0671@2|Bacteria,1RDK3@1224|Proteobacteria,2U7BJ@28211|Alphaproteobacteria,3K25S@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	PFAM phosphoesterase, PA-phosphatase related	-	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2
HKD2_k127_8112651_0	118173.KB235914_gene830	6.025e-263	834.0	COG0474@1|root,COG0474@2|Bacteria,1G2C4@1117|Cyanobacteria,1HE7Y@1150|Oscillatoriales	1117|Cyanobacteria	P	Cation transporter/ATPase, N-terminus	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
HKD2_k127_8112651_10	868131.MSWAN_0193	2.521e-32	135.0	COG3371@1|root,arCOG02008@2157|Archaea,2Y0X8@28890|Euryarchaeota	28890|Euryarchaeota	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF998
HKD2_k127_8112651_5	1242864.D187_004687	7.885e-85	299.0	COG3852@1|root,COG3852@2|Bacteria	2|Bacteria	T	phosphorelay sensor kinase activity	frgB	-	2.7.13.3	ko:K02668	ko02020,map02020	M00501	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	HATPase_c,HisKA,PAS,PAS_4,PAS_8
HKD2_k127_8112651_2	448385.sce1768	7.134e-102	348.0	2A4SI@1|root,30TDY@2|Bacteria,1PD6V@1224|Proteobacteria,435EQ@68525|delta/epsilon subdivisions,2X98Q@28221|Deltaproteobacteria,2Z2N2@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8112651_9	479433.Caci_6418	2.459e-37	148.0	COG2119@1|root,COG2119@2|Bacteria,2GNR0@201174|Actinobacteria	201174|Actinobacteria	O	membrane	-	-	-	-	-	-	-	-	-	-	-	-	UPF0016
HKD2_k127_8112651_13	1192034.CAP_3915	4.53e-18	99.0	COG0823@1|root,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	-	-	-	-	-	-	-	-	-	-	DUF4214,HYR,PD40,PKD,REJ
HKD2_k127_8112651_8	502025.Hoch_3674	1.148e-58	234.0	COG2010@1|root,COG4733@1|root,COG2010@2|Bacteria,COG4733@2|Bacteria	2|Bacteria	S	cellulase activity	-	-	-	-	-	-	-	-	-	-	-	-	CW_binding_2,PSCyt1,SLH,WD40,fn3
HKD2_k127_8112651_11	1192034.CAP_4466	1.589e-29	132.0	COG4105@1|root,COG4105@2|Bacteria	2|Bacteria	S	cell envelope organization	bamD	-	-	ko:K05807,ko:K08309	-	-	-	-	ko00000,ko01000,ko01011,ko02000	1.B.33.1	GH23	-	YfiO
HKD2_k127_8112651_4	1192034.CAP_6921	7.382e-87	314.0	COG0515@1|root,COG0515@2|Bacteria,1PFJ6@1224|Proteobacteria,4340Z@68525|delta/epsilon subdivisions,2X4J2@28221|Deltaproteobacteria,2YZ45@29|Myxococcales	28221|Deltaproteobacteria	KLT	Protein kinase domain	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
HKD2_k127_8112651_16	1894.JOER01000058_gene3221	4.72e-06	60.0	COG0265@1|root,COG2319@1|root,COG0265@2|Bacteria,COG2319@2|Bacteria,2GJN3@201174|Actinobacteria	201174|Actinobacteria	F	WD-40 repeat	-	-	-	-	-	-	-	-	-	-	-	-	Trypsin_2,WD40
HKD2_k127_8112651_3	1173025.GEI7407_3765	2.547e-92	326.0	28HX6@1|root,2Z82X@2|Bacteria,1G2BW@1117|Cyanobacteria,1HAG9@1150|Oscillatoriales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8112651_1	246197.MXAN_0256	5.984e-141	457.0	COG0075@1|root,COG0075@2|Bacteria,1MWHJ@1224|Proteobacteria,432W6@68525|delta/epsilon subdivisions,2WXSH@28221|Deltaproteobacteria,2Z2XE@29|Myxococcales	28221|Deltaproteobacteria	E	Aminotransferase class-V	-	-	2.6.1.44,2.6.1.45,2.6.1.51	ko:K00830	ko00250,ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko04146,map00250,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200,map04146	M00346,M00532	R00369,R00372,R00585,R00588	RC00006,RC00008,RC00018	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_5
HKD2_k127_8112651_7	290397.Adeh_3930	1.033e-61	216.0	COG0280@1|root,COG0281@1|root,COG0280@2|Bacteria,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,42MDI@68525|delta/epsilon subdivisions,2WIVY@28221|Deltaproteobacteria,2YXS2@29|Myxococcales	28221|Deltaproteobacteria	C	Malic enzyme, NAD binding domain	maeB	-	1.1.1.40	ko:K00029	ko00620,ko00710,ko01100,ko01120,ko01200,map00620,map00710,map01100,map01120,map01200	M00169,M00172	R00216	RC00105	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_1637	Malic_M,PTA_PTB,malic
HKD2_k127_8116174_12	1234364.AMSF01000003_gene2442	5.087e-41	161.0	COG0330@1|root,COG0330@2|Bacteria,1N5JY@1224|Proteobacteria,1RQKM@1236|Gammaproteobacteria,1X8SY@135614|Xanthomonadales	135614|Xanthomonadales	O	SPFH domain / Band 7 family	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
HKD2_k127_8116174_0	1254432.SCE1572_45120	2.402e-169	571.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,1MVEU@1224|Proteobacteria,43AGY@68525|delta/epsilon subdivisions,2X5WX@28221|Deltaproteobacteria,2YWWR@29|Myxococcales	28221|Deltaproteobacteria	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_12,TPR_7
HKD2_k127_8116174_8	502025.Hoch_5471	1.275e-51	197.0	COG1595@1|root,COG1595@2|Bacteria,1Q2GH@1224|Proteobacteria,43830@68525|delta/epsilon subdivisions,2X0DG@28221|Deltaproteobacteria,2YVH2@29|Myxococcales	28221|Deltaproteobacteria	K	DNA-binding regulatory protein	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r4_2
HKD2_k127_8116174_5	1254432.SCE1572_07635	7.703e-71	260.0	COG4637@1|root,COG4637@2|Bacteria,1Q2IF@1224|Proteobacteria,43857@68525|delta/epsilon subdivisions,2X3F5@28221|Deltaproteobacteria,2YVTM@29|Myxococcales	28221|Deltaproteobacteria	S	AAA ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_15,AAA_21
HKD2_k127_8116174_9	1192034.CAP_1516	4.222e-51	190.0	COG4123@1|root,COG4123@2|Bacteria,1RDSC@1224|Proteobacteria,42RIN@68525|delta/epsilon subdivisions,2WVJG@28221|Deltaproteobacteria,2YVZ6@29|Myxococcales	28221|Deltaproteobacteria	S	Methyltransferase small domain	-	-	2.1.1.223	ko:K15460	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	MTS,Methyltransf_31
HKD2_k127_8116174_6	1242864.D187_006540	3.053e-67	256.0	COG0308@1|root,COG0308@2|Bacteria,1P5AT@1224|Proteobacteria	1224|Proteobacteria	E	Peptidase family M1 domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M1
HKD2_k127_8116174_2	1192034.CAP_0774	2.301e-85	300.0	COG0515@1|root,COG0515@2|Bacteria	1192034.CAP_0774|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8116174_11	1254432.SCE1572_33835	2.361e-41	169.0	COG1729@1|root,COG1729@2|Bacteria	2|Bacteria	S	protein trimerization	cpoB	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_6,TolA_bind_tri
HKD2_k127_8116174_3	1192034.CAP_3731	4.306e-85	297.0	COG0584@1|root,COG0584@2|Bacteria,1N28H@1224|Proteobacteria	1224|Proteobacteria	C	glycerophosphoryl diester phosphodiesterase	-	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	DUF4996,GDPD
HKD2_k127_8116174_4	595460.RRSWK_06481	4.48e-71	247.0	COG1136@1|root,COG1136@2|Bacteria	2|Bacteria	V	lipoprotein transporter activity	hrtA	-	-	ko:K02003,ko:K09814	ko02010,map02010	M00257,M00258	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1	-	-	ABC_tran
HKD2_k127_8116174_1	595460.RRSWK_06482	6.44e-100	342.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HKD2_k127_8116174_10	595460.RRSWK_06483	9.622e-43	177.0	COG0845@1|root,COG0845@2|Bacteria,2IYTR@203682|Planctomycetes	203682|Planctomycetes	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_D23
HKD2_k127_8116174_13	404589.Anae109_3543	1.765e-26	116.0	COG1309@1|root,COG1309@2|Bacteria,1MWF7@1224|Proteobacteria,42NBZ@68525|delta/epsilon subdivisions,2WJ39@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	PFAM regulatory protein TetR	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_4,TetR_N
HKD2_k127_8116174_7	1192034.CAP_5160	1.022e-63	227.0	COG3568@1|root,COG3568@2|Bacteria,1N2ZJ@1224|Proteobacteria,42WUR@68525|delta/epsilon subdivisions,2WSUA@28221|Deltaproteobacteria,2YUA6@29|Myxococcales	28221|Deltaproteobacteria	PQ	Endonuclease/Exonuclease/phosphatase family	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos,LTD
HKD2_k127_8129026_3	1192034.CAP_4985	9.278e-25	120.0	COG3857@1|root,COG3857@2|Bacteria,1PD7D@1224|Proteobacteria,4373H@68525|delta/epsilon subdivisions,2X1XH@28221|Deltaproteobacteria,2YY2M@29|Myxococcales	28221|Deltaproteobacteria	L	PD-(D/E)XK nuclease superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_1
HKD2_k127_8129026_1	448385.sce2839	3.063e-144	501.0	COG1074@1|root,COG1074@2|Bacteria,1MUTF@1224|Proteobacteria,42NKH@68525|delta/epsilon subdivisions,2WJTY@28221|Deltaproteobacteria,2YZTG@29|Myxococcales	28221|Deltaproteobacteria	L	UvrD/REP helicase N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
HKD2_k127_8129026_2	448385.sce6487	6.1e-57	207.0	COG2003@1|root,COG2003@2|Bacteria,1MXZ5@1224|Proteobacteria,42PPW@68525|delta/epsilon subdivisions,2WM1S@28221|Deltaproteobacteria,2YVFT@29|Myxococcales	28221|Deltaproteobacteria	L	Belongs to the UPF0758 family	radC	-	-	ko:K03630	-	-	-	-	ko00000	-	-	-	RadC
HKD2_k127_8129026_0	1192034.CAP_2009	4.565e-191	614.0	COG3292@1|root,COG3292@2|Bacteria,1Q3P3@1224|Proteobacteria,439GA@68525|delta/epsilon subdivisions,2X4S8@28221|Deltaproteobacteria,2YZHD@29|Myxococcales	28221|Deltaproteobacteria	T	Two component regulator propeller	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8136764_2	1254432.SCE1572_23025	1.342e-32	134.0	COG2849@1|root,COG2849@2|Bacteria,1RJWA@1224|Proteobacteria,42VHV@68525|delta/epsilon subdivisions,2WRR0@28221|Deltaproteobacteria,2Z1RM@29|Myxococcales	28221|Deltaproteobacteria	S	repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8136764_3	1192034.CAP_6132	8.142e-23	102.0	2AIXI@1|root,319F6@2|Bacteria,1Q2J0@1224|Proteobacteria,4385U@68525|delta/epsilon subdivisions,2X3FN@28221|Deltaproteobacteria,2YVWG@29|Myxococcales	28221|Deltaproteobacteria	S	Ribbon-helix-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	RHH_3
HKD2_k127_8136764_0	448385.sce3836	1.427e-303	939.0	COG0481@1|root,COG0481@2|Bacteria,1MVZA@1224|Proteobacteria,42M3D@68525|delta/epsilon subdivisions,2WJEA@28221|Deltaproteobacteria,2YUH4@29|Myxococcales	28221|Deltaproteobacteria	J	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner	lepA	-	-	ko:K03596	ko05134,map05134	-	-	-	ko00000,ko00001	-	-	-	EFG_C,EFG_II,GTP_EFTU,GTP_EFTU_D2,LepA_C
HKD2_k127_8136764_1	448385.sce3834	7.041e-65	233.0	COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,42N0H@68525|delta/epsilon subdivisions,2WK9P@28221|Deltaproteobacteria,2YU0X@29|Myxococcales	28221|Deltaproteobacteria	S	Insulinase (Peptidase family M16)	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
HKD2_k127_8160858_1	448385.sce7931	6.667e-79	269.0	COG0642@1|root,COG2203@1|root,COG2203@2|Bacteria,COG2205@2|Bacteria,1R91W@1224|Proteobacteria,42PXP@68525|delta/epsilon subdivisions,2WJJX@28221|Deltaproteobacteria,2YX85@29|Myxococcales	28221|Deltaproteobacteria	T	GAF domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HATPase_c,HisKA,PAS,PAS_9
HKD2_k127_8160858_0	1192034.CAP_5784	4.755e-105	345.0	COG1216@1|root,COG1216@2|Bacteria,1QX3U@1224|Proteobacteria,42RP8@68525|delta/epsilon subdivisions,2WNF5@28221|Deltaproteobacteria,2Z30X@29|Myxococcales	28221|Deltaproteobacteria	S	Glycosyltransferase like family 2	-	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2
HKD2_k127_8160858_2	1192034.CAP_8409	4.296e-45	176.0	COG3917@1|root,COG3917@2|Bacteria,1RDNQ@1224|Proteobacteria,430PS@68525|delta/epsilon subdivisions,2WW31@28221|Deltaproteobacteria,2YVG0@29|Myxococcales	28221|Deltaproteobacteria	Q	DSBA-like thioredoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	DSBA
HKD2_k127_8160858_4	877455.Metbo_1854	1.433e-05	52.0	COG1226@1|root,arCOG01964@2157|Archaea,2Y19J@28890|Euryarchaeota	28890|Euryarchaeota	P	PFAM Ion	-	-	-	ko:K10716	-	-	-	-	ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	Ion_trans,Ion_trans_2
HKD2_k127_8160858_3	1129374.AJE_09969	6.676e-17	93.0	COG2268@1|root,COG2268@2|Bacteria,1P50K@1224|Proteobacteria,1RRHJ@1236|Gammaproteobacteria,465T9@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	protein conserved in bacteria	yqiK	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K07192	ko04910,map04910	-	-	-	ko00000,ko00001,ko03036,ko04131,ko04147	-	-	-	Band_7,Flot
HKD2_k127_8161373_11	1179773.BN6_67460	4.273e-05	55.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,2GMMM@201174|Actinobacteria,4DYU4@85010|Pseudonocardiales	201174|Actinobacteria	EV	WD40-like Beta Propeller Repeat	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase,PD40,Peptidase_S9
HKD2_k127_8161373_1	1192034.CAP_3532	5.274e-215	680.0	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,42M2A@68525|delta/epsilon subdivisions,2WJ41@28221|Deltaproteobacteria,2YUJJ@29|Myxococcales	28221|Deltaproteobacteria	S	ABC transporter, ATP-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,ABC_tran_Xtn
HKD2_k127_8161373_0	1254432.SCE1572_18250	1.041e-218	726.0	COG0515@1|root,COG0515@2|Bacteria,1PBV3@1224|Proteobacteria,438HA@68525|delta/epsilon subdivisions,2X3S2@28221|Deltaproteobacteria,2YWZ2@29|Myxococcales	28221|Deltaproteobacteria	KLT	Protein kinase domain	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
HKD2_k127_8161373_8	243233.MCA1365	1.817e-09	64.0	COG0727@1|root,COG0727@2|Bacteria,1N37X@1224|Proteobacteria	1224|Proteobacteria	S	Putative zinc- or iron-chelating domain	-	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
HKD2_k127_8161373_3	1144275.COCOR_01187	2.146e-72	254.0	COG3279@1|root,COG3279@2|Bacteria,1MVJI@1224|Proteobacteria,43ADC@68525|delta/epsilon subdivisions,2X5T8@28221|Deltaproteobacteria,2Z38R@29|Myxococcales	28221|Deltaproteobacteria	K	LytTr DNA-binding domain	lytT	-	-	ko:K02477,ko:K07705	ko02020,map02020	M00492	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	LytTR,Response_reg
HKD2_k127_8161373_2	246197.MXAN_1280	5.836e-110	367.0	COG2972@1|root,COG2972@2|Bacteria,1MXVQ@1224|Proteobacteria,42R4U@68525|delta/epsilon subdivisions,2X799@28221|Deltaproteobacteria,2YZAA@29|Myxococcales	28221|Deltaproteobacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K08082	ko02020,map02020	M00493	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	His_kinase
HKD2_k127_8161373_7	1323361.JPOC01000029_gene2339	6.052e-32	131.0	COG3439@1|root,COG3439@2|Bacteria,2IKVF@201174|Actinobacteria,4G245@85025|Nocardiaceae	201174|Actinobacteria	S	Domain of unknown function DUF302	-	-	-	-	-	-	-	-	-	-	-	-	DUF302
HKD2_k127_8161373_5	1192034.CAP_2118	1.5e-45	175.0	COG2010@1|root,COG2010@2|Bacteria,1PD95@1224|Proteobacteria,43E5K@68525|delta/epsilon subdivisions,2WZSQ@28221|Deltaproteobacteria,2Z2P1@29|Myxococcales	28221|Deltaproteobacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8161373_12	448385.sce3962	4.48e-05	54.0	COG0515@1|root,COG0515@2|Bacteria	448385.sce3962|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8161373_6	479433.Caci_6206	1.5e-34	141.0	2EFBW@1|root,3394U@2|Bacteria,2H758@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8161373_4	448385.sce3962	1.167e-65	237.0	COG0515@1|root,COG0515@2|Bacteria	448385.sce3962|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8161469_1	1144275.COCOR_02346	9.878e-06	53.0	COG2885@1|root,COG2885@2|Bacteria,1MZTV@1224|Proteobacteria,42R5H@68525|delta/epsilon subdivisions,2WNZS@28221|Deltaproteobacteria,2YVF4@29|Myxococcales	28221|Deltaproteobacteria	M	Belongs to the ompA family	pal	-	-	ko:K03640	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	OmpA
HKD2_k127_8161469_0	1192034.CAP_3886	3.422e-102	359.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria	1224|Proteobacteria	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HKD2_k127_8169627_3	246197.MXAN_4355	9.405e-55	197.0	COG2353@1|root,COG2353@2|Bacteria,1R9XD@1224|Proteobacteria,42T4I@68525|delta/epsilon subdivisions,2WQG9@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	YceI-like domain	-	-	-	-	-	-	-	-	-	-	-	-	YceI
HKD2_k127_8169627_2	1192034.CAP_0127	1.627e-111	384.0	COG0583@1|root,COG0583@2|Bacteria,1MZTA@1224|Proteobacteria,42V4K@68525|delta/epsilon subdivisions,2WRNR@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	Transcriptional regulator, LysR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HKD2_k127_8169627_0	448385.sce8819	1.689e-161	522.0	COG0737@1|root,COG0737@2|Bacteria,1MX03@1224|Proteobacteria,42Q71@68525|delta/epsilon subdivisions,2WK8Q@28221|Deltaproteobacteria,2Z1XZ@29|Myxococcales	28221|Deltaproteobacteria	F	Belongs to the 5'-nucleotidase family	-	-	3.1.3.5,3.6.1.45	ko:K11751	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	5_nucleotid_C,EF-hand_5,Metallophos
HKD2_k127_8169627_1	290397.Adeh_1573	2.367e-121	419.0	COG0477@1|root,COG0477@2|Bacteria,1RGPN@1224|Proteobacteria,43BMI@68525|delta/epsilon subdivisions,2X6ZQ@28221|Deltaproteobacteria,2Z3FD@29|Myxococcales	28221|Deltaproteobacteria	P	Major Facilitator Superfamily	-	-	-	ko:K03446	-	M00701	-	-	ko00000,ko00002,ko02000	2.A.1.3	-	-	MFS_1
HKD2_k127_8186338_0	1192034.CAP_4257	8.111e-140	454.0	COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,42MFC@68525|delta/epsilon subdivisions,2WJ4H@28221|Deltaproteobacteria,2YU21@29|Myxococcales	28221|Deltaproteobacteria	H	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor	bioA	-	2.6.1.62	ko:K00833	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03231	RC00006,RC00887	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	AAA_26,Aminotran_3
HKD2_k127_8186338_3	1302286.BAOT01000002_gene374	7.26e-08	64.0	COG4633@1|root,COG4633@2|Bacteria,1W06G@1239|Firmicutes,4HZAG@91061|Bacilli,3F7FA@33958|Lactobacillaceae	91061|Bacilli	S	Cupredoxin-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupredoxin_1
HKD2_k127_8186338_1	301.JNHE01000002_gene2255	7.543e-79	278.0	COG1024@1|root,COG1024@2|Bacteria,1NDT7@1224|Proteobacteria,1RSCI@1236|Gammaproteobacteria,1YEKG@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	4.2.1.17	ko:K01692	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
HKD2_k127_8186338_2	1254432.SCE1572_40325	1.035e-35	149.0	COG0457@1|root,COG3903@1|root,COG0457@2|Bacteria,COG3903@2|Bacteria,1MWPD@1224|Proteobacteria,438M3@68525|delta/epsilon subdivisions,2X1ZS@28221|Deltaproteobacteria,2YX8A@29|Myxococcales	28221|Deltaproteobacteria	T	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_22,Guanylate_cyc,TPR_12
HKD2_k127_8187971_2	1242864.D187_003103	1.293e-168	551.0	COG2409@1|root,COG2409@2|Bacteria,1R9Z8@1224|Proteobacteria	1224|Proteobacteria	S	MMPL family	ydfJ	-	-	ko:K06994	-	-	-	-	ko00000	-	-	-	MMPL
HKD2_k127_8187971_0	1192034.CAP_3148	0.0	1050.0	COG3857@1|root,COG3857@2|Bacteria,1QXU1@1224|Proteobacteria,43C6K@68525|delta/epsilon subdivisions,2X7GU@28221|Deltaproteobacteria,2Z1DQ@29|Myxococcales	28221|Deltaproteobacteria	L	PD-(D/E)XK nuclease superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_1
HKD2_k127_8187971_1	1254432.SCE1572_00460	2.726e-226	748.0	COG1074@1|root,COG1074@2|Bacteria,1MUTF@1224|Proteobacteria,42NKH@68525|delta/epsilon subdivisions,2WJTY@28221|Deltaproteobacteria,2YUG5@29|Myxococcales	28221|Deltaproteobacteria	L	UvrD/REP helicase N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
HKD2_k127_8250099_3	248742.XP_005644982.1	1.258e-14	78.0	COG1011@1|root,KOG3085@2759|Eukaryota,37QNX@33090|Viridiplantae,34P5V@3041|Chlorophyta	3041|Chlorophyta	S	Haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
HKD2_k127_8250099_2	448385.sce7135	2.439e-18	96.0	COG5502@1|root,COG5502@2|Bacteria,1QAI7@1224|Proteobacteria,4353X@68525|delta/epsilon subdivisions,2X954@28221|Deltaproteobacteria,2Z1ZQ@29|Myxococcales	28221|Deltaproteobacteria	S	Uncharacterized conserved protein (DUF2267)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2267
HKD2_k127_8250099_0	1254432.SCE1572_46565	1.989e-126	421.0	COG0160@1|root,COG0160@2|Bacteria,1MWY6@1224|Proteobacteria,42MB7@68525|delta/epsilon subdivisions,2WJVU@28221|Deltaproteobacteria,2YWB2@29|Myxococcales	28221|Deltaproteobacteria	H	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.19,2.6.1.22	ko:K00823,ko:K07250	ko00250,ko00280,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00280,map00410,map00640,map00650,map01100,map01120	M00027	R00908,R01648,R04188	RC00006,RC00062,RC00160	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
HKD2_k127_8250099_1	448385.sce8626	2.712e-103	339.0	COG1716@1|root,COG2199@1|root,COG1716@2|Bacteria,COG3706@2|Bacteria,1MZV7@1224|Proteobacteria,43BQ2@68525|delta/epsilon subdivisions,2WQ6X@28221|Deltaproteobacteria,2YWRT@29|Myxococcales	28221|Deltaproteobacteria	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	FHA,GGDEF,Yop-YscD_cpl
HKD2_k127_8259654_11	216142.LT40_03320	2.704e-07	56.0	COG1633@1|root,COG1633@2|Bacteria,1N4K6@1224|Proteobacteria,1T0VP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Domain of unknown function (DUF2383)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2383
HKD2_k127_8259654_4	215803.DB30_0946	1.997e-47	190.0	COG2382@1|root,COG2382@2|Bacteria,1QX4D@1224|Proteobacteria,438NV@68525|delta/epsilon subdivisions,2X29M@28221|Deltaproteobacteria,2YXD1@29|Myxococcales	28221|Deltaproteobacteria	P	Putative esterase	-	-	-	-	-	-	-	-	-	-	-	-	Esterase
HKD2_k127_8259654_7	977880.RALTA_B0678	1.533e-41	164.0	COG1295@1|root,COG1295@2|Bacteria,1R9UY@1224|Proteobacteria,2VJV0@28216|Betaproteobacteria,1KH2P@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Virulence factor BrkB	-	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Virul_fac_BrkB
HKD2_k127_8259654_8	378806.STAUR_4298	1.814e-38	149.0	COG0071@1|root,COG0071@2|Bacteria,1N7C7@1224|Proteobacteria,42U0T@68525|delta/epsilon subdivisions,2WRBN@28221|Deltaproteobacteria,2Z0B0@29|Myxococcales	28221|Deltaproteobacteria	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
HKD2_k127_8259654_6	472759.Nhal_1889	7.514e-45	171.0	COG0778@1|root,COG0778@2|Bacteria,1RJMP@1224|Proteobacteria,1T0ZH@1236|Gammaproteobacteria,1X0TI@135613|Chromatiales	135613|Chromatiales	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
HKD2_k127_8259654_2	1192034.CAP_9032	2.035e-88	317.0	COG1470@1|root,COG1470@2|Bacteria,1P6QQ@1224|Proteobacteria,4385T@68525|delta/epsilon subdivisions,2X3FM@28221|Deltaproteobacteria,2YVWE@29|Myxococcales	28221|Deltaproteobacteria	S	cell adhesion involved in biofilm formation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8259654_10	215803.DB30_5103	3.317e-08	67.0	COG1413@1|root,COG1413@2|Bacteria,1N55Z@1224|Proteobacteria,42Q7F@68525|delta/epsilon subdivisions,2WPWV@28221|Deltaproteobacteria,2YU62@29|Myxococcales	28221|Deltaproteobacteria	C	PBS lyase HEAT-like repeat	-	-	-	-	-	-	-	-	-	-	-	-	HEAT,HEAT_2,HEAT_PBS
HKD2_k127_8259654_5	448385.sce0366	2.232e-45	170.0	COG0723@1|root,COG0723@2|Bacteria,1NINP@1224|Proteobacteria,42X9Z@68525|delta/epsilon subdivisions,2WSPW@28221|Deltaproteobacteria,2YVVX@29|Myxococcales	28221|Deltaproteobacteria	C	Rieske [2Fe-2S] domain	cbcV	-	1.10.9.1	ko:K02636	ko00195,ko01100,map00195,map01100	M00162	R03817,R08409	RC01002	ko00000,ko00001,ko00002,ko00194,ko01000	-	-	iAF987.Gmet_1922	CytB6-F_Fe-S,Rieske
HKD2_k127_8259654_1	1254432.SCE1572_02805	2.827e-125	422.0	COG1290@1|root,COG2010@1|root,COG1290@2|Bacteria,COG2010@2|Bacteria,1MV97@1224|Proteobacteria,42MD6@68525|delta/epsilon subdivisions,2WPA2@28221|Deltaproteobacteria,2YUJZ@29|Myxococcales	28221|Deltaproteobacteria	C	Cytochrome b subunit of the bc complex	cbcW	-	-	ko:K00412	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002,ko03029	-	-	-	Cytochrom_B_C,Cytochrom_B_N_2,Cytochrom_C,Cytochrome_B,Cytochrome_CBB3
HKD2_k127_8259654_0	1254432.SCE1572_17685	3.484e-289	934.0	COG0515@1|root,COG2203@1|root,COG3829@1|root,COG0515@2|Bacteria,COG2203@2|Bacteria,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,43BKG@68525|delta/epsilon subdivisions,2X6YI@28221|Deltaproteobacteria,2YTVN@29|Myxococcales	28221|Deltaproteobacteria	K	Bacterial regulatory protein, Fis family	-	-	-	ko:K02584	ko02020,map02020	-	-	-	ko00000,ko00001,ko03000	-	-	-	GAF,GAF_2,HTH_8,Pkinase,PocR,Sigma54_activat
HKD2_k127_8299949_0	448385.sce0033	1.061e-211	671.0	COG1508@1|root,COG1508@2|Bacteria,1MW4V@1224|Proteobacteria,42M3C@68525|delta/epsilon subdivisions,2WJ21@28221|Deltaproteobacteria,2YTW6@29|Myxococcales	28221|Deltaproteobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	rpoN	-	-	ko:K03092	ko02020,ko05111,map02020,map05111	-	-	-	ko00000,ko00001,ko03021	-	-	-	Sigma54_AID,Sigma54_CBD,Sigma54_DBD
HKD2_k127_8299949_2	448385.sce3927	1.411e-178	579.0	COG1360@1|root,COG1360@2|Bacteria,1R0CK@1224|Proteobacteria,43CV5@68525|delta/epsilon subdivisions,2X830@28221|Deltaproteobacteria,2Z3JV@29|Myxococcales	28221|Deltaproteobacteria	N	Flagellar Motor Protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8299949_7	215803.DB30_1834	1.504e-45	180.0	COG2094@1|root,COG2094@2|Bacteria,1RE0A@1224|Proteobacteria,42VWF@68525|delta/epsilon subdivisions,2WRX8@28221|Deltaproteobacteria,2YVKZ@29|Myxococcales	28221|Deltaproteobacteria	L	Belongs to the DNA glycosylase MPG family	-	-	3.2.2.21	ko:K03652	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Pur_DNA_glyco
HKD2_k127_8299949_8	1254432.SCE1572_17410	1.978e-38	149.0	COG1664@1|root,COG1664@2|Bacteria,1N7TF@1224|Proteobacteria,42VWZ@68525|delta/epsilon subdivisions,2WRPF@28221|Deltaproteobacteria,2YVIX@29|Myxococcales	28221|Deltaproteobacteria	M	Polymer-forming cytoskeletal	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
HKD2_k127_8299949_3	1254432.SCE1572_48660	3.779e-103	352.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,43AKM@68525|delta/epsilon subdivisions,2X60K@28221|Deltaproteobacteria,2Z39T@29|Myxococcales	28221|Deltaproteobacteria	T	HAMP domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
HKD2_k127_8299949_5	1254432.SCE1572_48685	2.312e-81	278.0	COG0726@1|root,COG0726@2|Bacteria,1PJQG@1224|Proteobacteria,42W09@68525|delta/epsilon subdivisions,2WRB8@28221|Deltaproteobacteria,2YVVC@29|Myxococcales	28221|Deltaproteobacteria	G	Polysaccharide deacetylase	-	-	3.5.1.104	ko:K22278	-	-	-	-	ko00000,ko01000	-	-	-	Polysacc_deac_1
HKD2_k127_8299949_1	378806.STAUR_3879	1.104e-186	607.0	COG0507@1|root,COG0507@2|Bacteria,1MW43@1224|Proteobacteria,42M8J@68525|delta/epsilon subdivisions,2WJD6@28221|Deltaproteobacteria,2YTW8@29|Myxococcales	28221|Deltaproteobacteria	L	DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity	recD2	-	3.1.11.5	ko:K03581	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AAA_30,HHH_4,HHH_5,UvrD_C_2
HKD2_k127_8299949_6	278963.ATWD01000001_gene1983	1.506e-48	181.0	COG2095@1|root,COG2095@2|Bacteria,3Y429@57723|Acidobacteria,2JI6F@204432|Acidobacteriia	204432|Acidobacteriia	U	MarC family integral membrane protein	-	-	-	ko:K05595	-	-	-	-	ko00000,ko02000	2.A.95.1	-	-	MarC
HKD2_k127_8299949_4	1120973.AQXL01000106_gene1894	4.201e-82	288.0	COG4992@1|root,COG4992@2|Bacteria,1TP9S@1239|Firmicutes,4HBY4@91061|Bacilli,278WY@186823|Alicyclobacillaceae	91061|Bacilli	E	Aminotransferase class-III	-	-	2.6.1.82	ko:K09251	ko00330,ko01100,map00330,map01100	-	R01155	RC00006,RC00062	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_3
HKD2_k127_831804_2	378806.STAUR_5411	0.000273	52.0	COG2267@1|root,COG2267@2|Bacteria,1MWF5@1224|Proteobacteria,42T8M@68525|delta/epsilon subdivisions,2WPBS@28221|Deltaproteobacteria,2YW9W@29|Myxococcales	28221|Deltaproteobacteria	I	Serine aminopeptidase, S33	agmH	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4
HKD2_k127_831804_1	1267533.KB906737_gene1762	2.496e-13	78.0	COG3108@1|root,COG3108@2|Bacteria,3Y4G1@57723|Acidobacteria,2JJ25@204432|Acidobacteriia	204432|Acidobacteriia	S	Bacterial protein of unknown function (DUF882)	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M15_2
HKD2_k127_831804_0	1192034.CAP_4573	3.415e-70	256.0	COG3203@1|root,COG3203@2|Bacteria	2|Bacteria	M	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane	oprD	-	-	ko:K18093	ko01501,ko02020,map01501,map02020	M00745	-	-	ko00000,ko00001,ko00002,ko01000,ko01504,ko02000	1.B.25.1.1	-	iJN746.PP_1206	Alginate_exp,BBP2,OprD,Porin_4
HKD2_k127_8324941_0	1254432.SCE1572_04460	2.368e-137	445.0	COG0556@1|root,COG0556@2|Bacteria,1MUFK@1224|Proteobacteria,42MFA@68525|delta/epsilon subdivisions,2WJ20@28221|Deltaproteobacteria,2YU4B@29|Myxococcales	28221|Deltaproteobacteria	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	-	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
HKD2_k127_8338570_0	448385.sce1616	1.573e-140	467.0	COG0457@1|root,COG0457@2|Bacteria,1PEH7@1224|Proteobacteria,42TVC@68525|delta/epsilon subdivisions,2WSCX@28221|Deltaproteobacteria,2YXM3@29|Myxococcales	28221|Deltaproteobacteria	O	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,TPR_14,TPR_16,TPR_2,TPR_4,TPR_6,TPR_8
HKD2_k127_8338570_1	1162668.LFE_1236	1.094e-57	222.0	COG0477@1|root,COG2814@2|Bacteria	2|Bacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD2_k127_8338570_4	1122211.JMLW01000003_gene1833	2.249e-40	172.0	COG1858@1|root,COG1858@2|Bacteria,1MV70@1224|Proteobacteria,1RPPQ@1236|Gammaproteobacteria,1XH2W@135619|Oceanospirillales	135619|Oceanospirillales	C	Cytochrome c peroxidase	-	-	1.11.1.5	ko:K00428	-	-	-	-	ko00000,ko01000	-	-	-	CCP_MauG,Cytochrom_C
HKD2_k127_8338570_2	1121124.JNIX01000008_gene2466	1.068e-56	214.0	COG4447@1|root,COG4447@2|Bacteria,1R9D5@1224|Proteobacteria,2UPW4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8338570_3	378806.STAUR_1566	1.405e-53	201.0	COG2114@1|root,COG3903@1|root,COG2114@2|Bacteria,COG3903@2|Bacteria,1MWPD@1224|Proteobacteria,433Y0@68525|delta/epsilon subdivisions,2X9PW@28221|Deltaproteobacteria,2YXYI@29|Myxococcales	28221|Deltaproteobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc
HKD2_k127_8348712_19	305700.B447_02688	2.359e-08	59.0	COG1216@1|root,COG3119@1|root,COG1216@2|Bacteria,COG3119@2|Bacteria,1MV0B@1224|Proteobacteria,2VMN9@28216|Betaproteobacteria,2KVMN@206389|Rhodocyclales	206389|Rhodocyclales	P	Type I phosphodiesterase / nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2,Sulfatase
HKD2_k127_8348712_0	1254432.SCE1572_11780	7.412e-233	767.0	COG0457@1|root,COG0515@1|root,COG3899@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG3899@2|Bacteria,1QA6R@1224|Proteobacteria,438FC@68525|delta/epsilon subdivisions,2X3QC@28221|Deltaproteobacteria,2YWU9@29|Myxococcales	28221|Deltaproteobacteria	KLT	Family membership	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,Pkinase
HKD2_k127_8348712_18	91464.S7335_774	1.153e-11	73.0	COG0589@1|root,COG0589@2|Bacteria,1G6JK@1117|Cyanobacteria,1H1YU@1129|Synechococcus	1117|Cyanobacteria	T	T COG0589 Universal stress protein UspA and related nucleotide-binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD2_k127_8348712_11	502025.Hoch_0450	2.532e-58	233.0	COG0484@1|root,COG0484@2|Bacteria,1QABU@1224|Proteobacteria,434YT@68525|delta/epsilon subdivisions,2WZ9Q@28221|Deltaproteobacteria,2Z1NF@29|Myxococcales	28221|Deltaproteobacteria	C	heat shock protein binding	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8348712_1	502025.Hoch_0451	1.033e-216	715.0	COG0484@1|root,COG0484@2|Bacteria,1MXM9@1224|Proteobacteria,4397N@68525|delta/epsilon subdivisions,2X4EI@28221|Deltaproteobacteria,2YYVA@29|Myxococcales	28221|Deltaproteobacteria	C	heat shock protein binding	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C7
HKD2_k127_8348712_12	502025.Hoch_0452	1.173e-54	203.0	COG0492@1|root,COG0492@2|Bacteria	2|Bacteria	C	ferredoxin-NADP+ reductase activity	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_2,FAD_oxidored,Pyr_redox_2,Thioredoxin_3,cNMP_binding
HKD2_k127_8348712_4	502025.Hoch_0453	7.768e-134	441.0	COG0492@1|root,COG1145@1|root,COG0492@2|Bacteria,COG1145@2|Bacteria,1NDW6@1224|Proteobacteria,42MUD@68525|delta/epsilon subdivisions,2WKZ9@28221|Deltaproteobacteria,2YYPV@29|Myxococcales	28221|Deltaproteobacteria	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_10,Pyr_redox_3
HKD2_k127_8348712_14	502025.Hoch_0454	1.201e-20	104.0	COG0484@1|root,COG0484@2|Bacteria	2|Bacteria	O	heat shock protein binding	hmcA	GO:0005575,GO:0005623,GO:0042597,GO:0044464	-	-	-	-	-	-	-	-	-	-	Cytochrom_CIII
HKD2_k127_8348712_6	215803.DB30_5487	7.683e-82	282.0	COG0583@1|root,COG0583@2|Bacteria,1MW16@1224|Proteobacteria,43F2U@68525|delta/epsilon subdivisions,2WYPV@28221|Deltaproteobacteria,2YUFA@29|Myxococcales	28221|Deltaproteobacteria	K	Bacterial regulatory helix-turn-helix protein, lysR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HKD2_k127_8348712_7	926560.KE387025_gene4132	2.596e-77	265.0	COG2085@1|root,COG2085@2|Bacteria,1WMWM@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	NADP oxidoreductase coenzyme F420-dependent	-	-	-	-	-	-	-	-	-	-	-	-	F420_oxidored
HKD2_k127_8348712_8	1192034.CAP_0452	4.086e-66	231.0	COG0500@1|root,COG2226@2|Bacteria,1PVPS@1224|Proteobacteria,43DGN@68525|delta/epsilon subdivisions,2X8NF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	Q	Mycolic acid cyclopropane synthetase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8348712_10	1304888.ATWF01000001_gene1671	3.019e-61	216.0	COG0652@1|root,COG0652@2|Bacteria,2GG0J@200930|Deferribacteres	200930|Deferribacteres	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	-	-	5.2.1.8	ko:K01802	-	-	-	-	ko00000,ko01000	-	-	-	Pro_isomerase
HKD2_k127_8348712_2	936455.KI421499_gene3132	2.989e-192	615.0	COG0659@1|root,COG0659@2|Bacteria,1MWDF@1224|Proteobacteria,2TT0G@28211|Alphaproteobacteria,3JVT8@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Sulfate permease family	-	-	-	-	-	-	-	-	-	-	-	-	STAS,Sulfate_transp
HKD2_k127_8348712_17	1297742.A176_00551	4.849e-12	70.0	2BFCF@1|root,3295Q@2|Bacteria,1QNB9@1224|Proteobacteria,433TW@68525|delta/epsilon subdivisions,2X9YD@28221|Deltaproteobacteria,2YVW3@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8348712_15	1210884.HG799470_gene14433	8.162e-18	90.0	COG1595@1|root,COG1595@2|Bacteria,2IZ91@203682|Planctomycetes	203682|Planctomycetes	K	TIGRFAM RNA polymerase sigma factor, sigma-70 family	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD2_k127_8348712_3	1192034.CAP_1498	3e-143	471.0	COG0823@1|root,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	-	-	-	-	-	-	-	-	-	-	DUF4214,HYR,PD40,PKD,REJ
HKD2_k127_8348712_16	316067.Geob_0123	1.296e-13	76.0	COG0723@1|root,COG0723@2|Bacteria,1NINP@1224|Proteobacteria,42VKD@68525|delta/epsilon subdivisions,2WRHY@28221|Deltaproteobacteria,43UPC@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Rieske [2Fe-2S] domain	pcmE	-	1.10.9.1	ko:K02636,ko:K03886	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00151,M00162	R03817,R08409	RC01002	ko00000,ko00001,ko00002,ko00194,ko01000	-	-	-	Rieske
HKD2_k127_8348712_21	1144275.COCOR_05840	6.152e-06	58.0	COG3325@1|root,COG3325@2|Bacteria,1RI4Q@1224|Proteobacteria	1224|Proteobacteria	G	Belongs to the glycosyl hydrolase 18 family	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_18
HKD2_k127_8348712_20	1254432.SCE1572_22375	3.246e-07	61.0	COG3055@1|root,COG3227@1|root,COG4412@1|root,COG3055@2|Bacteria,COG3227@2|Bacteria,COG4412@2|Bacteria,1QT4U@1224|Proteobacteria,437RQ@68525|delta/epsilon subdivisions,2X4KF@28221|Deltaproteobacteria,2YZ72@29|Myxococcales	28221|Deltaproteobacteria	E	M6 family metalloprotease domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8348712_9	1313421.JHBV01000016_gene5489	1.721e-64	231.0	COG4942@1|root,COG4942@2|Bacteria	2|Bacteria	D	peptidase	-	-	-	ko:K19304	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	DUF3375
HKD2_k127_8371052_1	1192034.CAP_3564	4.959e-176	554.0	COG2006@1|root,COG2006@2|Bacteria,1NSD4@1224|Proteobacteria,42YV4@68525|delta/epsilon subdivisions,2WTK6@28221|Deltaproteobacteria,2YWVS@29|Myxococcales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
HKD2_k127_8371052_6	246197.MXAN_3573	1.273e-15	86.0	COG4305@1|root,COG4305@2|Bacteria,1MYW4@1224|Proteobacteria,434JK@68525|delta/epsilon subdivisions,2WYWV@28221|Deltaproteobacteria,2Z0TT@29|Myxococcales	28221|Deltaproteobacteria	G	Rare lipoprotein A (RlpA)-like double-psi beta-barrel	-	-	-	ko:K20628	-	-	-	-	ko00000	-	-	-	DPBB_1,Pollen_allerg_1
HKD2_k127_8371052_4	1242864.D187_000143	2.85e-72	262.0	COG1793@1|root,COG3285@1|root,COG1793@2|Bacteria,COG3285@2|Bacteria,1MVWY@1224|Proteobacteria,42NN9@68525|delta/epsilon subdivisions,2WM5V@28221|Deltaproteobacteria,2Z32B@29|Myxococcales	28221|Deltaproteobacteria	L	DNA polymerase Ligase (LigD)	ligD	-	6.5.1.1	ko:K01971	ko03450,map03450	-	R00381	RC00005	ko00000,ko00001,ko01000,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,LigD_N
HKD2_k127_8371052_2	448385.sce2607	2.406e-109	377.0	COG1397@1|root,COG1397@2|Bacteria,1Q3FK@1224|Proteobacteria,4397S@68525|delta/epsilon subdivisions,2X4EP@28221|Deltaproteobacteria,2YYVJ@29|Myxococcales	28221|Deltaproteobacteria	O	ADP-ribosylglycohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8371052_3	1192034.CAP_1743	3.826e-75	266.0	COG0515@1|root,COG0515@2|Bacteria	1192034.CAP_1743|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8371052_5	448385.sce3997	4.504e-66	241.0	COG0515@1|root,COG0515@2|Bacteria	448385.sce3997|-	KLT	protein kinase activity	-	-	2.7.11.1	ko:K08884	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	-
HKD2_k127_8371052_0	1192034.CAP_8215	3.883e-184	597.0	COG0366@1|root,COG0366@2|Bacteria,1PG5R@1224|Proteobacteria,43DZ4@68525|delta/epsilon subdivisions,2X92U@28221|Deltaproteobacteria,2Z1M5@29|Myxococcales	28221|Deltaproteobacteria	G	Alpha-amylase domain	-	-	3.2.1.1	ko:K01176	ko00500,ko01100,ko04973,map00500,map01100,map04973	-	R02108,R02112,R11262	-	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase
HKD2_k127_8374642_4	1192034.CAP_1993	3.986e-48	179.0	COG5394@1|root,COG5394@2|Bacteria,1RHRC@1224|Proteobacteria,42WB9@68525|delta/epsilon subdivisions,2WSSJ@28221|Deltaproteobacteria,2YVJB@29|Myxococcales	28221|Deltaproteobacteria	S	PHB/PHA accumulation regulator DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	PHB_acc_N
HKD2_k127_8374642_2	1254432.SCE1572_43760	1.125e-77	268.0	COG1120@1|root,COG1120@2|Bacteria,1MUNG@1224|Proteobacteria,42P8N@68525|delta/epsilon subdivisions,2X84B@28221|Deltaproteobacteria,2Z3KP@29|Myxococcales	28221|Deltaproteobacteria	P	ABC transporter	-	-	3.6.3.34	ko:K02013	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14	-	-	ABC_tran
HKD2_k127_8374642_5	448385.sce9086	4.636e-34	138.0	COG0526@1|root,COG0526@2|Bacteria,1N726@1224|Proteobacteria,42U61@68525|delta/epsilon subdivisions,2WQRF@28221|Deltaproteobacteria,2YVYE@29|Myxococcales	28221|Deltaproteobacteria	CO	Redoxin	dsbE	-	-	ko:K02199	-	-	-	-	ko00000,ko03110	-	-	-	AhpC-TSA
HKD2_k127_8374642_1	1254432.SCE1572_37145	7.848e-93	325.0	COG3950@1|root,COG3950@2|Bacteria,1PKXP@1224|Proteobacteria,439S9@68525|delta/epsilon subdivisions,2X556@28221|Deltaproteobacteria,2Z04Q@29|Myxococcales	28221|Deltaproteobacteria	S	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8378195_1	1144275.COCOR_01074	7.303e-97	319.0	COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,43AEE@68525|delta/epsilon subdivisions,2WIRF@28221|Deltaproteobacteria,2YU6I@29|Myxococcales	28221|Deltaproteobacteria	I	Carboxyl transferase domain	pccB	-	2.1.3.1,2.1.3.15,6.4.1.3	ko:K01966,ko:K17489	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R00353,R01859	RC00040,RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
HKD2_k127_8378195_0	1254432.SCE1572_42310	3.27e-165	529.0	COG1509@1|root,COG1509@2|Bacteria,1MUPJ@1224|Proteobacteria,42MNR@68525|delta/epsilon subdivisions,2WJ70@28221|Deltaproteobacteria,2YU37@29|Myxococcales	28221|Deltaproteobacteria	C	lysine 2,3-aminomutase	kamA	-	5.4.3.2	ko:K01843	ko00310,map00310	-	R00461	RC00303	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Fer4_14,LAM_C,Radical_SAM
HKD2_k127_8378195_2	448385.sce7260	3.517e-06	51.0	COG0760@1|root,COG0760@2|Bacteria,1MZDK@1224|Proteobacteria,42RP3@68525|delta/epsilon subdivisions,2WNPA@28221|Deltaproteobacteria,2YVS3@29|Myxococcales	28221|Deltaproteobacteria	O	PFAM PpiC-type peptidyl-prolyl cis-trans isomerase	-	-	5.2.1.8	ko:K03769,ko:K03770	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_2,Rotamase_3,SurA_N_3
HKD2_k127_8381259_0	1192034.CAP_4442	3.964e-116	392.0	COG0515@1|root,COG0515@2|Bacteria	1192034.CAP_4442|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8435293_3	290397.Adeh_3956	2.057e-21	99.0	2A9VF@1|root,30Z3B@2|Bacteria,1PKZS@1224|Proteobacteria,435JG@68525|delta/epsilon subdivisions,2WZXJ@28221|Deltaproteobacteria,2Z0YG@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8435293_1	1192034.CAP_6813	5.726e-53	213.0	COG1807@1|root,COG1807@2|Bacteria	2|Bacteria	M	4-amino-4-deoxy-L-arabinose transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HKD2_k127_8435293_0	448385.sce3638	3.947e-64	235.0	COG1520@1|root,COG1520@2|Bacteria,1Q3BK@1224|Proteobacteria,4392T@68525|delta/epsilon subdivisions,2X48J@28221|Deltaproteobacteria,2YYHQ@29|Myxococcales	28221|Deltaproteobacteria	S	PQQ-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2
HKD2_k127_8435345_3	1192034.CAP_7895	7.121e-36	157.0	2BP52@1|root,32HVW@2|Bacteria,1QAR1@1224|Proteobacteria,4358W@68525|delta/epsilon subdivisions,2WZK1@28221|Deltaproteobacteria,2Z2AG@29|Myxococcales	28221|Deltaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_6
HKD2_k127_8435345_0	448385.sce2044	5.425e-119	391.0	COG2008@1|root,COG2008@2|Bacteria,1MWCR@1224|Proteobacteria,42MZS@68525|delta/epsilon subdivisions,2WIQP@28221|Deltaproteobacteria,2YUBW@29|Myxococcales	28221|Deltaproteobacteria	E	Threonine aldolase	ltaA	-	4.1.2.48	ko:K01620	ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230	-	R00751,R06171	RC00312,RC00372	ko00000,ko00001,ko01000	-	-	-	Beta_elim_lyase
HKD2_k127_8435345_4	1223545.GS4_05_03110	8.57e-18	94.0	COG2186@1|root,COG2186@2|Bacteria,2I90D@201174|Actinobacteria,4GD4M@85026|Gordoniaceae	201174|Actinobacteria	K	FCD	mce2R	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009605,GO:0009607,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032991,GO:0032993,GO:0043207,GO:0043565,GO:0044403,GO:0044419,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0060255,GO:0065007,GO:0075136,GO:0080090,GO:0097159,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141	-	-	-	-	-	-	-	-	-	-	FCD,GntR
HKD2_k127_8435345_1	1192034.CAP_6559	7.003e-115	389.0	COG2303@1|root,COG2303@2|Bacteria,1P9UF@1224|Proteobacteria,43A4M@68525|delta/epsilon subdivisions,2WYKE@28221|Deltaproteobacteria,2Z0NN@29|Myxococcales	1224|Proteobacteria	E	GMC oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GMC_oxred_C,GMC_oxred_N
HKD2_k127_8442971_1	1122604.JONR01000022_gene629	4.281e-26	113.0	COG1309@1|root,COG1309@2|Bacteria,1RAF9@1224|Proteobacteria,1SHKH@1236|Gammaproteobacteria,1XAIW@135614|Xanthomonadales	135614|Xanthomonadales	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
HKD2_k127_8442971_0	1095769.CAHF01000022_gene143	3.184e-220	692.0	COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,2VIY8@28216|Betaproteobacteria	28216|Betaproteobacteria	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
HKD2_k127_84524_0	1429046.RR21198_4468	2.962e-115	384.0	COG1680@1|root,COG1680@2|Bacteria,2GJJB@201174|Actinobacteria,4FXBC@85025|Nocardiaceae	201174|Actinobacteria	V	COG1680 Beta-lactamase class C and other penicillin binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
HKD2_k127_84524_1	204669.Acid345_2712	1.568e-106	358.0	COG3005@1|root,COG3005@2|Bacteria,3Y3MU@57723|Acidobacteria,2JJ6B@204432|Acidobacteriia	57723|Acidobacteria	C	NapC/NirT cytochrome c family, N-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_NNT
HKD2_k127_8460144_0	622637.KE124774_gene314	2.102e-126	435.0	COG0477@1|root,COG2814@2|Bacteria,1MVSH@1224|Proteobacteria,2TUEW@28211|Alphaproteobacteria,36Y2U@31993|Methylocystaceae	28211|Alphaproteobacteria	EGP	Major Facilitator Superfamily	MA20_27925	-	-	ko:K08151	-	M00668	-	-	ko00000,ko00002,ko01504,ko02000	2.A.1.2.38,2.A.1.2.39,2.A.1.2.4,2.A.1.2.41,2.A.1.2.68,2.A.1.2.75	-	-	MFS_1,Sugar_tr
HKD2_k127_8460144_6	856793.MICA_1331	0.0008889	52.0	COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,2TR7W@28211|Alphaproteobacteria,4BPSZ@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamA	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
HKD2_k127_8460144_5	94624.Bpet0761	0.0001171	52.0	COG0760@1|root,COG0760@2|Bacteria,1MVB3@1224|Proteobacteria,2VHHS@28216|Betaproteobacteria,3T26Z@506|Alcaligenaceae	28216|Betaproteobacteria	M	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation	surA	-	5.2.1.8	ko:K03771	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_3,SurA_N
HKD2_k127_8460144_1	909943.HIMB100_00002260	3.679e-26	124.0	COG0545@1|root,COG0607@1|root,COG0545@2|Bacteria,COG0607@2|Bacteria,1RDA1@1224|Proteobacteria,2UCPG@28211|Alphaproteobacteria,4BS6C@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	O	FKBP-type peptidyl-prolyl cis-trans isomerase	-	-	-	-	-	-	-	-	-	-	-	-	FKBP_C,Rhodanese
HKD2_k127_8460144_3	1192034.CAP_3741	9.323e-12	74.0	COG0760@1|root,COG0760@2|Bacteria,1MVB3@1224|Proteobacteria,42QXH@68525|delta/epsilon subdivisions,2WMN3@28221|Deltaproteobacteria,2YVIS@29|Myxococcales	28221|Deltaproteobacteria	M	SurA N-terminal domain	surA	-	5.2.1.8	ko:K03771	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_2,Rotamase_3,SurA_N,SurA_N_3
HKD2_k127_8460144_4	1254432.SCE1572_44095	7.302e-05	46.0	COG2006@1|root,COG2006@2|Bacteria	2|Bacteria	U	4fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF2088,DUF362
HKD2_k127_8471650_2	1125971.ASJB01000057_gene5235	3.676e-11	75.0	COG2905@1|root,COG2905@2|Bacteria,2I3QN@201174|Actinobacteria,4EDY3@85010|Pseudonocardiales	201174|Actinobacteria	T	BON domain	-	-	-	-	-	-	-	-	-	-	-	-	BON,CBS,Usp
HKD2_k127_8471650_1	575540.Isop_0773	4.681e-15	85.0	COG2374@1|root,COG2374@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_5,LTD
HKD2_k127_8471650_0	1254432.SCE1572_34115	6.885e-26	113.0	COG0823@1|root,COG0823@2|Bacteria,1RI0N@1224|Proteobacteria	1224|Proteobacteria	U	PA14 domain	-	-	-	-	-	-	-	-	-	-	-	-	PA14,VPEP
HKD2_k127_84754_0	1177181.T9A_02173	1.716e-37	155.0	COG1073@1|root,COG1073@2|Bacteria,1PQAX@1224|Proteobacteria,1S02C@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	alpha beta	-	-	-	-	-	-	-	-	-	-	-	-	DUF2048
HKD2_k127_8490739_1	1121933.AUHH01000002_gene1803	1.07e-20	102.0	COG1051@1|root,COG1051@2|Bacteria,2IQEU@201174|Actinobacteria,4DSD6@85009|Propionibacteriales	201174|Actinobacteria	F	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
HKD2_k127_8490739_0	502025.Hoch_5894	2.997e-45	178.0	COG5459@1|root,COG5459@2|Bacteria,1MWMM@1224|Proteobacteria,42WIB@68525|delta/epsilon subdivisions,2WRHR@28221|Deltaproteobacteria,2Z341@29|Myxococcales	28221|Deltaproteobacteria	J	Mitochondrial small ribosomal subunit Rsm22	-	-	-	-	-	-	-	-	-	-	-	-	Rsm22
HKD2_k127_852390_2	1380394.JADL01000002_gene1192	2.873e-65	241.0	COG0500@1|root,COG0500@2|Bacteria,1MX2X@1224|Proteobacteria,2TSMI@28211|Alphaproteobacteria,2JRRH@204441|Rhodospirillales	204441|Rhodospirillales	Q	Predicted methyltransferase regulatory domain	-	-	-	-	-	-	-	-	-	-	-	-	MethyTransf_Reg,Methyltransf_31
HKD2_k127_852390_1	502025.Hoch_5062	3.073e-165	532.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,42M0R@68525|delta/epsilon subdivisions,2WJE6@28221|Deltaproteobacteria,2YYYY@29|Myxococcales	28221|Deltaproteobacteria	C	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.3.8.4	ko:K00253	ko00280,ko01100,map00280,map01100	M00036	R04095	RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HKD2_k127_852390_0	34839.XP_005381048.1	2.449e-261	839.0	COG0058@1|root,KOG2099@2759|Eukaryota,38F0I@33154|Opisthokonta,3BD45@33208|Metazoa,3CSQ6@33213|Bilateria,4869N@7711|Chordata,48V4R@7742|Vertebrata,3J5I7@40674|Mammalia,358ZV@314146|Euarchontoglires,4Q2QI@9989|Rodentia	33208|Metazoa	G	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties	PYGB	GO:0000272,GO:0000323,GO:0001775,GO:0002252,GO:0002263,GO:0002274,GO:0002275,GO:0002283,GO:0002366,GO:0002376,GO:0002443,GO:0002444,GO:0002446,GO:0003674,GO:0003824,GO:0004645,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005764,GO:0005766,GO:0005773,GO:0005775,GO:0005975,GO:0005976,GO:0005977,GO:0005980,GO:0005981,GO:0006073,GO:0006091,GO:0006109,GO:0006112,GO:0006810,GO:0006887,GO:0006955,GO:0007275,GO:0007568,GO:0008144,GO:0008150,GO:0008152,GO:0008184,GO:0008340,GO:0009056,GO:0009057,GO:0009251,GO:0009893,GO:0009894,GO:0009896,GO:0009987,GO:0010259,GO:0010604,GO:0010675,GO:0010676,GO:0010906,GO:0010907,GO:0012505,GO:0015980,GO:0016052,GO:0016192,GO:0016740,GO:0016757,GO:0016758,GO:0019222,GO:0019842,GO:0030141,GO:0030170,GO:0030246,GO:0030424,GO:0031323,GO:0031325,GO:0031329,GO:0031331,GO:0031410,GO:0031974,GO:0031982,GO:0031983,GO:0032501,GO:0032502,GO:0032881,GO:0032940,GO:0032991,GO:0034774,GO:0035578,GO:0036094,GO:0036230,GO:0042119,GO:0042582,GO:0042802,GO:0042803,GO:0042995,GO:0043005,GO:0043167,GO:0043168,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043299,GO:0043312,GO:0043467,GO:0043470,GO:0043471,GO:0044042,GO:0044237,GO:0044238,GO:0044247,GO:0044248,GO:0044260,GO:0044262,GO:0044264,GO:0044275,GO:0044422,GO:0044424,GO:0044433,GO:0044437,GO:0044444,GO:0044446,GO:0044464,GO:0045055,GO:0045321,GO:0045819,GO:0045913,GO:0046903,GO:0046983,GO:0048037,GO:0048518,GO:0048522,GO:0048856,GO:0050662,GO:0050789,GO:0050794,GO:0050896,GO:0051179,GO:0051234,GO:0055114,GO:0060205,GO:0060255,GO:0062012,GO:0062013,GO:0065007,GO:0070013,GO:0070279,GO:0070873,GO:0070875,GO:0071704,GO:0080090,GO:0097159,GO:0097458,GO:0097708,GO:0099503,GO:0120025,GO:1901363,GO:1901575	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	Phosphorylase
HKD2_k127_852390_3	519989.ECTPHS_04975	3.679e-12	78.0	COG3118@1|root,COG3118@2|Bacteria,1MV0R@1224|Proteobacteria,1RMSQ@1236|Gammaproteobacteria,1WXMF@135613|Chromatiales	135613|Chromatiales	O	PFAM Thioredoxin	-	-	-	ko:K05838	-	-	-	-	ko00000,ko03110	-	-	-	TPR_19,TPR_20,Thioredoxin
HKD2_k127_8547087_3	502025.Hoch_2211	2.204e-102	345.0	COG1233@1|root,COG1233@2|Bacteria,1MV2R@1224|Proteobacteria,43BX1@68525|delta/epsilon subdivisions,2X77U@28221|Deltaproteobacteria,2YTZ8@29|Myxococcales	28221|Deltaproteobacteria	Q	Phytoene dehydrogenase	-	-	1.3.99.26,1.3.99.28,1.3.99.29,1.3.99.31	ko:K10027	ko00906,ko01100,ko01110,map00906,map01100,map01110	-	R04787,R04798,R04800,R09691,R09692	RC01214,RC02088,RC02605	ko00000,ko00001,ko01000	-	-	-	Amino_oxidase
HKD2_k127_8547087_5	502025.Hoch_2210	9.527e-77	269.0	COG0142@1|root,COG0142@2|Bacteria,1NXYK@1224|Proteobacteria,430UK@68525|delta/epsilon subdivisions,2WVY1@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	Belongs to the FPP GGPP synthase family	-	-	-	-	-	-	-	-	-	-	-	-	polyprenyl_synt
HKD2_k127_8547087_2	502025.Hoch_2209	3.265e-113	379.0	COG0644@1|root,COG0644@2|Bacteria,1QVKV@1224|Proteobacteria	1224|Proteobacteria	C	lycopene cyclase	crtY	-	5.5.1.19	ko:K06443	ko00906,ko01100,ko01110,map00906,map01100,map01110	M00097	R03824,R04801,R05341,R06962,R07856	RC01004,RC01964	ko00000,ko00001,ko00002,ko01000	-	-	-	Lycopene_cycl
HKD2_k127_8547087_4	1192034.CAP_0217	2.036e-92	310.0	298PG@1|root,2ZVTY@2|Bacteria,1RIKV@1224|Proteobacteria,433IU@68525|delta/epsilon subdivisions,2WXIH@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8547087_0	1278073.MYSTI_02498	5e-324	1029.0	COG0823@1|root,COG0823@2|Bacteria,1NR88@1224|Proteobacteria,437C2@68525|delta/epsilon subdivisions,2X9JB@28221|Deltaproteobacteria,2YXU7@29|Myxococcales	28221|Deltaproteobacteria	U	WD40-like Beta Propeller Repeat	-	-	-	-	-	-	-	-	-	-	-	-	PD40
HKD2_k127_8547087_1	246197.MXAN_4306	3.791e-192	645.0	COG2911@1|root,COG2911@2|Bacteria,1N9X4@1224|Proteobacteria,4342H@68525|delta/epsilon subdivisions,2X4UP@28221|Deltaproteobacteria,2YZMQ@29|Myxococcales	28221|Deltaproteobacteria	S	Protein conserved in bacteria	-	-	-	ko:K09800	-	-	-	-	ko00000,ko02000	-	-	-	-
HKD2_k127_8547087_6	449447.MAE_09800	1.026e-20	100.0	COG0580@1|root,COG0580@2|Bacteria,1G0AW@1117|Cyanobacteria	1117|Cyanobacteria	U	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity	aqpZ	-	-	ko:K06188	-	-	-	-	ko00000,ko02000	1.A.8	-	iJN678.apqZ	MIP
HKD2_k127_8572562_7	485913.Krac_4700	1.351e-07	63.0	2DRZ7@1|root,33DSV@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8572562_4	290397.Adeh_3883	4.589e-51	205.0	COG1032@1|root,COG1032@2|Bacteria,1MWR0@1224|Proteobacteria,42PFW@68525|delta/epsilon subdivisions,2WJ1N@28221|Deltaproteobacteria,2Z1PP@29|Myxococcales	28221|Deltaproteobacteria	C	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM,TPR_14,TPR_16
HKD2_k127_8572562_3	1254432.SCE1572_24105	4.174e-55	210.0	COG0515@1|root,COG0515@2|Bacteria	1254432.SCE1572_24105|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8572562_8	1155718.KB891885_gene6335	3.314e-06	60.0	COG0515@1|root,COG1520@1|root,COG0515@2|Bacteria,COG1520@2|Bacteria,2GIV0@201174|Actinobacteria	201174|Actinobacteria	KLT	serine threonine protein kinase	afsK	-	-	-	-	-	-	-	-	-	-	-	PQQ_2,PQQ_3,Pkinase
HKD2_k127_8572562_2	1192034.CAP_2668	4.89e-62	226.0	COG1470@1|root,COG1470@2|Bacteria,1QZIJ@1224|Proteobacteria,43CK1@68525|delta/epsilon subdivisions,2X7UG@28221|Deltaproteobacteria,2YY6W@29|Myxococcales	28221|Deltaproteobacteria	S	PEGA domain	-	-	-	-	-	-	-	-	-	-	-	-	PEGA
HKD2_k127_8572562_0	448385.sce4512	2.596e-77	274.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,42MVV@68525|delta/epsilon subdivisions,2X4JB@28221|Deltaproteobacteria,2YZ4I@29|Myxococcales	28221|Deltaproteobacteria	KLT	Family membership	-	-	2.7.11.1	ko:K08884	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HKD2_k127_8572562_1	340177.Cag_0264	2.314e-67	238.0	COG1136@1|root,COG1136@2|Bacteria,1FDCB@1090|Chlorobi	1090|Chlorobi	V	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner	lolD1	-	-	ko:K09810	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.125	-	-	ABC_tran
HKD2_k127_8572562_5	932678.THERU_03170	1.165e-33	135.0	COG4591@1|root,COG4591@2|Bacteria,2G4G5@200783|Aquificae	200783|Aquificae	M	MacB-like periplasmic core domain	-	-	-	ko:K09808	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.125	-	-	FtsX,MacB_PCD
HKD2_k127_8573831_1	67373.JOBF01000002_gene1249	1.027e-08	65.0	COG3391@1|root,COG3391@2|Bacteria,2GK45@201174|Actinobacteria	201174|Actinobacteria	M	40-residue YVTN family beta-propeller repeat	-	-	-	-	-	-	-	-	-	-	-	-	Lactonase,PD40,PQQ_2
HKD2_k127_8580888_0	448385.sce2962	1.809e-208	668.0	COG1028@1|root,COG3347@1|root,COG1028@2|Bacteria,COG3347@2|Bacteria,1MWSB@1224|Proteobacteria,42MXK@68525|delta/epsilon subdivisions,2WKEJ@28221|Deltaproteobacteria,2YZ1K@29|Myxococcales	28221|Deltaproteobacteria	IQ	Class II Aldolase and Adducin N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Aldolase_II,adh_short,adh_short_C2
HKD2_k127_8640916_0	448385.sce8308	3.124e-181	571.0	COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,42M81@68525|delta/epsilon subdivisions,2WJXY@28221|Deltaproteobacteria,2YWNM@29|Myxococcales	28221|Deltaproteobacteria	C	Fumarate reductase flavoprotein C-term	sdhA	-	1.3.5.1,1.3.5.4	ko:K00239,ko:K00244	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,ko05134,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020,map05134	M00009,M00011,M00149,M00150,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
HKD2_k127_8640916_1	1196029.ALIM01000014_gene2732	1.015e-23	111.0	COG2009@1|root,COG2009@2|Bacteria,1TQUI@1239|Firmicutes,4HBX0@91061|Bacilli,1ZBB5@1386|Bacillus	91061|Bacilli	C	succinate dehydrogenase	sdhC	-	-	ko:K00241	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002	-	-	iYO844.BSU28450	Sdh_cyt
HKD2_k127_866707_1	1254432.SCE1572_15525	8.424e-65	235.0	COG0265@1|root,COG0526@1|root,COG0265@2|Bacteria,COG0526@2|Bacteria,1QAS6@1224|Proteobacteria,4359M@68525|delta/epsilon subdivisions,2WZKT@28221|Deltaproteobacteria,2Z2BZ@29|Myxococcales	28221|Deltaproteobacteria	O	Domain present in PSD-95, Dlg, and ZO-1/2.	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,PDZ_2
HKD2_k127_866707_0	1254432.SCE1572_15530	4.97e-99	351.0	COG3552@1|root,COG3552@2|Bacteria,1MUHH@1224|Proteobacteria,42QBK@68525|delta/epsilon subdivisions,2WITZ@28221|Deltaproteobacteria,2YW16@29|Myxococcales	28221|Deltaproteobacteria	S	VWA domain containing CoxE-like protein	-	-	-	ko:K07161	-	-	-	-	ko00000	-	-	-	VWA_CoxE
HKD2_k127_866707_3	1192034.CAP_0201	1.202e-25	117.0	COG3221@1|root,COG3221@2|Bacteria,1MXD8@1224|Proteobacteria,42VZ4@68525|delta/epsilon subdivisions,2WRDI@28221|Deltaproteobacteria,2YW4T@29|Myxococcales	28221|Deltaproteobacteria	P	ABC transporter, phosphonate, periplasmic substrate-binding protein	phnD	-	-	ko:K02044	ko02010,map02010	M00223	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.9	-	-	Phosphonate-bd
HKD2_k127_866707_2	448385.sce8631	2.085e-59	208.0	COG1477@1|root,COG1477@2|Bacteria,1MW6K@1224|Proteobacteria,42MZQ@68525|delta/epsilon subdivisions,2WJNE@28221|Deltaproteobacteria,2YV2N@29|Myxococcales	28221|Deltaproteobacteria	H	Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein	-	-	2.7.1.180	ko:K03734	-	-	-	-	ko00000,ko01000	-	-	-	ApbE,MFS_1
HKD2_k127_866804_2	1054213.HMPREF9946_02011	9.531e-70	248.0	COG3569@1|root,COG3569@2|Bacteria,1MVJ9@1224|Proteobacteria,2TUAH@28211|Alphaproteobacteria,2JR0N@204441|Rhodospirillales	204441|Rhodospirillales	L	Eukaryotic DNA topoisomerase I, catalytic core	-	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_I
HKD2_k127_866804_0	1267535.KB906767_gene1151	9.529e-287	893.0	COG1048@1|root,COG1048@2|Bacteria,3Y4NH@57723|Acidobacteria	57723|Acidobacteria	C	Aconitase family (aconitate hydratase)	-	-	-	-	-	-	-	-	-	-	-	-	Aconitase,Aconitase_C
HKD2_k127_866804_7	477184.KYC_17588	5.512e-13	72.0	2E3SC@1|root,32YPX@2|Bacteria,1N7IU@1224|Proteobacteria,2VWD1@28216|Betaproteobacteria,3T81Y@506|Alcaligenaceae	28216|Betaproteobacteria	S	Protein of unknown function (DUF1059)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1059
HKD2_k127_866804_1	391625.PPSIR1_06271	6.1e-92	314.0	COG0500@1|root,COG2226@2|Bacteria,1QZSU@1224|Proteobacteria,42PXS@68525|delta/epsilon subdivisions,2X7UZ@28221|Deltaproteobacteria,2Z3I9@29|Myxococcales	28221|Deltaproteobacteria	H	O-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_2
HKD2_k127_866804_3	29306.JOBE01000001_gene2614	2.414e-62	229.0	COG3568@1|root,COG3568@2|Bacteria,2IGGC@201174|Actinobacteria	201174|Actinobacteria	S	Endonuclease/Exonuclease/phosphatase family	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
HKD2_k127_866804_4	376733.IT41_15215	2.758e-56	225.0	COG1858@1|root,COG1858@2|Bacteria,1MV70@1224|Proteobacteria,2VAMY@28211|Alphaproteobacteria,2PYYA@265|Paracoccus	28211|Alphaproteobacteria	C	Di-haem cytochrome c peroxidase	-	-	1.11.1.5	ko:K00428	-	-	-	-	ko00000,ko01000	-	-	-	CCP_MauG
HKD2_k127_866804_6	1150626.PHAMO_270143	2.586e-31	138.0	COG0845@1|root,COG0845@2|Bacteria,1P540@1224|Proteobacteria,2U20J@28211|Alphaproteobacteria,2JQX7@204441|Rhodospirillales	204441|Rhodospirillales	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_D23
HKD2_k127_866804_5	1114964.L485_09150	3.587e-39	168.0	COG4591@1|root,COG4591@2|Bacteria,1Q2BY@1224|Proteobacteria,2TVP1@28211|Alphaproteobacteria,2K3FR@204457|Sphingomonadales	204457|Sphingomonadales	M	MacB-like periplasmic core domain	-	-	-	ko:K09808	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.125	-	-	FtsX,MacB_PCD
HKD2_k127_8682379_2	448385.sce7292	6.748e-15	76.0	COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,42M4Z@68525|delta/epsilon subdivisions,2WJ0D@28221|Deltaproteobacteria,2YUHW@29|Myxococcales	28221|Deltaproteobacteria	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
HKD2_k127_8682379_1	1254432.SCE1572_42480	5.796e-67	239.0	COG0037@1|root,COG0037@2|Bacteria,1MU85@1224|Proteobacteria,42NF0@68525|delta/epsilon subdivisions,2WIJK@28221|Deltaproteobacteria,2YVDX@29|Myxococcales	28221|Deltaproteobacteria	J	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine	tilS	-	6.3.4.19	ko:K04075	-	-	R09597	RC02633,RC02634	ko00000,ko01000,ko03016	-	-	-	ATP_bind_3,TilS,TilS_C
HKD2_k127_8682379_0	448385.sce7294	1.058e-87	310.0	COG2265@1|root,COG2265@2|Bacteria,1MV3A@1224|Proteobacteria,42ME9@68525|delta/epsilon subdivisions,2WKF0@28221|Deltaproteobacteria,2YV7V@29|Myxococcales	28221|Deltaproteobacteria	H	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family	rumA	-	2.1.1.190	ko:K03215	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TRAM,tRNA_U5-meth_tr
HKD2_k127_8682763_0	448385.sce6261	6.276e-87	307.0	COG1716@1|root,COG1716@2|Bacteria,1N5QD@1224|Proteobacteria,4382E@68525|delta/epsilon subdivisions,2X3CH@28221|Deltaproteobacteria,2YVEM@29|Myxococcales	28221|Deltaproteobacteria	T	Forkhead associated domain	-	-	-	-	-	-	-	-	-	-	-	-	FHA
HKD2_k127_8804519_4	1254432.SCE1572_10475	1.153e-16	81.0	COG2001@1|root,COG2001@2|Bacteria,1RHCG@1224|Proteobacteria,42TRZ@68525|delta/epsilon subdivisions,2WQRI@28221|Deltaproteobacteria,2YYCH@29|Myxococcales	28221|Deltaproteobacteria	K	Belongs to the MraZ family	mraZ	GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031333,GO:0043254,GO:0043565,GO:0044087,GO:0044212,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2000142,GO:2000143,GO:2001141	-	ko:K03925	-	-	-	-	ko00000	-	-	-	MraZ
HKD2_k127_8804519_2	1173263.Syn7502_02986	2.435e-39	158.0	COG0500@1|root,COG0500@2|Bacteria,1G56P@1117|Cyanobacteria,1H0ID@1129|Synechococcus	1117|Cyanobacteria	Q	Thiopurine S-methyltransferase (TPMT)	-	-	2.1.1.67	ko:K00569	ko00983,map00983	-	R08236,R08239,R08246	RC00003,RC00980,RC02277	ko00000,ko00001,ko01000	-	-	-	TPMT
HKD2_k127_8804519_0	639030.JHVA01000001_gene1215	2.186e-129	424.0	COG1960@1|root,COG1960@2|Bacteria,3Y3T6@57723|Acidobacteria,2JIV6@204432|Acidobacteriia	204432|Acidobacteriia	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HKD2_k127_8804519_3	448385.sce8315	8.176e-20	102.0	COG3591@1|root,COG3591@2|Bacteria	2|Bacteria	E	Belongs to the peptidase S1B family	-	-	-	-	-	-	-	-	-	-	-	-	Trypsin
HKD2_k127_8804519_1	448385.sce1655	2.969e-66	227.0	COG2185@1|root,COG2185@2|Bacteria,1RKGS@1224|Proteobacteria,42SKV@68525|delta/epsilon subdivisions,2WP2X@28221|Deltaproteobacteria,2YV7A@29|Myxococcales	28221|Deltaproteobacteria	I	B12 binding domain	-	-	5.4.99.2	ko:K01849	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding
HKD2_k127_8873546_5	215803.DB30_1013	3.205e-15	90.0	COG1073@1|root,COG1073@2|Bacteria,1NVTC@1224|Proteobacteria,42Z2F@68525|delta/epsilon subdivisions,2WTUN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	COG1073 hydrolases of the alpha beta superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_bact_N
HKD2_k127_8873546_0	234267.Acid_1858	3.111e-156	507.0	COG0439@1|root,COG0439@2|Bacteria,3Y3FH@57723|Acidobacteria	57723|Acidobacteria	I	Biotin carboxylase C-terminal domain	-	-	6.3.4.14,6.4.1.2	ko:K01961	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04385	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
HKD2_k127_8873546_1	1192034.CAP_0399	4.301e-149	515.0	COG5316@1|root,COG5316@2|Bacteria,1NWFX@1224|Proteobacteria,42NSK@68525|delta/epsilon subdivisions,2WMAZ@28221|Deltaproteobacteria,2YUUF@29|Myxococcales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF4139)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4139
HKD2_k127_8873546_3	448385.sce3796	3.177e-51	183.0	COG0545@1|root,COG0545@2|Bacteria,1RDA1@1224|Proteobacteria,42TNB@68525|delta/epsilon subdivisions,2WQIG@28221|Deltaproteobacteria,2Z0TE@29|Myxococcales	28221|Deltaproteobacteria	O	FKBP-type peptidyl-prolyl cis-trans isomerase	-	-	5.2.1.8	ko:K01802,ko:K03772	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	FKBP_C
HKD2_k127_8873546_2	1192034.CAP_1583	2.288e-93	338.0	COG1633@1|root,COG1633@2|Bacteria,1R8DF@1224|Proteobacteria	1224|Proteobacteria	S	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8873546_6	448385.sce8826	1.879e-05	58.0	COG2133@1|root,COG2133@2|Bacteria	2|Bacteria	G	pyrroloquinoline quinone binding	-	-	-	-	-	-	-	-	-	-	-	-	Big_5,F5_F8_type_C,PA14,Phosphoesterase
HKD2_k127_8879773_8	1192034.CAP_7887	1.116e-06	53.0	COG0745@1|root,COG0745@2|Bacteria,1MVCB@1224|Proteobacteria,42RGE@68525|delta/epsilon subdivisions,2WNF7@28221|Deltaproteobacteria,2YUAH@29|Myxococcales	28221|Deltaproteobacteria	K	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
HKD2_k127_8879773_6	215803.DB30_4283	2.372e-22	104.0	COG5612@1|root,COG5612@2|Bacteria,1PBU8@1224|Proteobacteria,433TF@68525|delta/epsilon subdivisions,2X3E2@28221|Deltaproteobacteria,2YVN2@29|Myxococcales	28221|Deltaproteobacteria	S	Heavy-metal resistance	-	-	-	-	-	-	-	-	-	-	-	-	Metal_resist
HKD2_k127_8879773_1	1254432.SCE1572_21985	1.014e-55	201.0	COG1595@1|root,COG1595@2|Bacteria,1NY42@1224|Proteobacteria,431SP@68525|delta/epsilon subdivisions,2WW84@28221|Deltaproteobacteria,2Z1C0@29|Myxococcales	28221|Deltaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD2_k127_8879773_0	1192034.CAP_6584	2.399e-66	251.0	COG1502@1|root,COG1502@2|Bacteria,1MWUW@1224|Proteobacteria,43BFU@68525|delta/epsilon subdivisions,2X5HG@28221|Deltaproteobacteria,2YUGC@29|Myxococcales	28221|Deltaproteobacteria	I	Phospholipase D. Active site motifs.	-	-	-	ko:K06131	ko00564,ko01100,map00564,map01100	-	R07390	RC00017	ko00000,ko00001,ko01000	-	-	-	PLDc_2
HKD2_k127_8879773_3	1192034.CAP_0610	3.954e-38	164.0	COG0204@1|root,COG0204@2|Bacteria,1Q8VU@1224|Proteobacteria,437GX@68525|delta/epsilon subdivisions,2X2Q3@28221|Deltaproteobacteria,2Z0YC@29|Myxococcales	28221|Deltaproteobacteria	I	Phosphate acyltransferases	-	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
HKD2_k127_8879773_7	1254432.SCE1572_32350	1.487e-11	64.0	COG2104@1|root,COG2104@2|Bacteria,1NG8E@1224|Proteobacteria,42WUA@68525|delta/epsilon subdivisions,2X2JA@28221|Deltaproteobacteria,2YW1J@29|Myxococcales	28221|Deltaproteobacteria	H	Thiamine biosynthesis	-	-	-	ko:K03154	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
HKD2_k127_8886918_0	1242864.D187_002248	7.201e-63	247.0	COG3831@1|root,COG3831@2|Bacteria,1QWC3@1224|Proteobacteria	1224|Proteobacteria	S	Domain of unknown function (DUF4132)	JD73_20480	-	-	-	-	-	-	-	-	-	-	-	DUF4132,WGR
HKD2_k127_8886918_1	1464048.JNZS01000020_gene2256	7.712e-10	71.0	COG1409@1|root,COG1409@2|Bacteria,2IM97@201174|Actinobacteria,4D9VR@85008|Micromonosporales	201174|Actinobacteria	S	Calcineurin-like phosphoesterase	-	-	3.1.3.1	ko:K01077	ko00730,ko00790,ko01100,ko02020,map00730,map00790,map01100,map02020	M00126	R02135,R04620	RC00017	ko00000,ko00001,ko00002,ko00537,ko01000,ko04147	-	-	-	Metallophos
HKD2_k127_8932597_0	1254432.SCE1572_10600	4.773e-79	274.0	COG4221@1|root,COG4221@2|Bacteria,1QVCA@1224|Proteobacteria,431MP@68525|delta/epsilon subdivisions,2WWCC@28221|Deltaproteobacteria,2Z3JH@29|Myxococcales	28221|Deltaproteobacteria	S	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HKD2_k127_8932597_1	502025.Hoch_3958	1.986e-39	156.0	2BU90@1|root,32PIH@2|Bacteria,1Q490@1224|Proteobacteria,43E5M@68525|delta/epsilon subdivisions,2WZSU@28221|Deltaproteobacteria,2Z2P7@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8944273_1	448385.sce7270	2.13e-55	201.0	COG1193@1|root,COG1193@2|Bacteria,1QUJI@1224|Proteobacteria,42P7P@68525|delta/epsilon subdivisions,2WK5H@28221|Deltaproteobacteria,2YTYQ@29|Myxococcales	28221|Deltaproteobacteria	L	Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity	mutS2	-	-	ko:K07456	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_V,Smr
HKD2_k127_8944273_2	1192034.CAP_4607	1.593e-21	106.0	COG1716@1|root,COG1716@2|Bacteria,1PYKW@1224|Proteobacteria,435FF@68525|delta/epsilon subdivisions,2WZSZ@28221|Deltaproteobacteria,2Z2PG@29|Myxococcales	28221|Deltaproteobacteria	T	FHA domain	-	-	-	-	-	-	-	-	-	-	-	-	FHA
HKD2_k127_8944273_0	1278073.MYSTI_03905	1.345e-193	624.0	COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,43C02@68525|delta/epsilon subdivisions,2X7AU@28221|Deltaproteobacteria,2YU9K@29|Myxococcales	28221|Deltaproteobacteria	KT	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	FHA,GAF,GAF_2,HTH_8,Sigma54_activat,Yop-YscD_cpl
HKD2_k127_8944800_1	1192034.CAP_4611	1.53e-31	125.0	COG0755@1|root,COG0755@2|Bacteria,1MU61@1224|Proteobacteria,42RU4@68525|delta/epsilon subdivisions,2WNN7@28221|Deltaproteobacteria,2YVGN@29|Myxococcales	28221|Deltaproteobacteria	O	Cytochrome C assembly protein	ccmC	-	-	ko:K02195	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.107	-	-	Cytochrom_C_asm
HKD2_k127_8944800_0	1192034.CAP_4608	3.755e-166	531.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,42MK5@68525|delta/epsilon subdivisions,2WJ3Z@28221|Deltaproteobacteria,2YUET@29|Myxococcales	28221|Deltaproteobacteria	C	Acyl-CoA dehydrogenase, N-terminal domain	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HKD2_k127_8944815_2	1254432.SCE1572_42735	1.034e-39	149.0	COG3118@1|root,COG3118@2|Bacteria,1MZBB@1224|Proteobacteria,42TPU@68525|delta/epsilon subdivisions,2WQ1M@28221|Deltaproteobacteria,2YVHU@29|Myxococcales	28221|Deltaproteobacteria	O	Belongs to the thioredoxin family	trxA	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
HKD2_k127_8944815_3	448385.sce5165	7.891e-32	144.0	COG0515@1|root,COG0515@2|Bacteria,1QA6R@1224|Proteobacteria	1224|Proteobacteria	KLT	serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,Pkinase
HKD2_k127_8944815_1	1192034.CAP_8891	8.382e-83	289.0	COG1408@1|root,COG1408@2|Bacteria,1MUH5@1224|Proteobacteria,42Q51@68525|delta/epsilon subdivisions,2WIMQ@28221|Deltaproteobacteria,2YYKM@29|Myxococcales	28221|Deltaproteobacteria	S	Calcineurin-like phosphoesterase	-	-	-	ko:K07098	-	-	-	-	ko00000	-	-	-	CarS-like,Metallophos
HKD2_k127_8944815_0	1254432.SCE1572_48610	1.203e-84	288.0	COG0616@1|root,COG0616@2|Bacteria,1MUXE@1224|Proteobacteria,42QUN@68525|delta/epsilon subdivisions,2WN6Q@28221|Deltaproteobacteria,2YU60@29|Myxococcales	28221|Deltaproteobacteria	OU	signal peptide peptidase SppA, 36K type	sppA2	-	-	ko:K04773	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S49
HKD2_k127_8945182_2	1192034.CAP_0108	9.978e-16	77.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,42M51@68525|delta/epsilon subdivisions,2WIPP@28221|Deltaproteobacteria,2YTYC@29|Myxococcales	28221|Deltaproteobacteria	NU	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB	pilB	-	-	ko:K02652	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE,T2SSE_N,cNMP_binding
HKD2_k127_8945182_1	1254432.SCE1572_27265	7.447e-52	198.0	COG1716@1|root,COG1716@2|Bacteria	2|Bacteria	T	histone H2A K63-linked ubiquitination	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	DUF3662,FHA,Pkinase,Yop-YscD_cpl
HKD2_k127_8945182_3	1121022.ABENE_20220	3.691e-07	63.0	COG1434@1|root,COG1434@2|Bacteria,1P97H@1224|Proteobacteria,2TV8I@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	DUF218 domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF218
HKD2_k127_8947032_0	324602.Caur_3150	9.475e-261	816.0	COG1048@1|root,COG1048@2|Bacteria,2G5NG@200795|Chloroflexi,374T1@32061|Chloroflexia	32061|Chloroflexia	C	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate	-	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
HKD2_k127_8947032_1	502025.Hoch_3515	1.428e-75	269.0	2AN4U@1|root,31D2K@2|Bacteria,1QA4B@1224|Proteobacteria,434U7@68525|delta/epsilon subdivisions,2WZ56@28221|Deltaproteobacteria,2Z1CN@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8947032_2	1410634.JHVD01000014_gene488	3.803e-12	73.0	COG0207@1|root,COG0207@2|Bacteria,2GKY0@201174|Actinobacteria,4DPMT@85009|Propionibacteriales	201174|Actinobacteria	F	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis	thyA	GO:0003674,GO:0003824,GO:0004799,GO:0006139,GO:0006220,GO:0006221,GO:0006231,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0009056,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009125,GO:0009129,GO:0009130,GO:0009131,GO:0009157,GO:0009159,GO:0009162,GO:0009165,GO:0009166,GO:0009176,GO:0009177,GO:0009178,GO:0009219,GO:0009221,GO:0009223,GO:0009262,GO:0009263,GO:0009264,GO:0009265,GO:0009394,GO:0009987,GO:0016740,GO:0016741,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0032259,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042083,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046073,GO:0046078,GO:0046079,GO:0046385,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0072529,GO:0090407,GO:1901135,GO:1901136,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576	2.1.1.45	ko:K00560	ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523	M00053	R02101	RC00219,RC00332	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylat_synt
HKD2_k127_8949238_0	1192034.CAP_3040	2.469e-91	306.0	COG1360@1|root,COG5316@1|root,COG1360@2|Bacteria,COG5316@2|Bacteria	2|Bacteria	N	Flagellar Motor Protein	-	-	-	ko:K11892	ko03070,map03070	M00334	-	-	ko00000,ko00001,ko00002,ko02044	3.A.23.1	-	-	DUF4139,DotU,OmpA
HKD2_k127_8949238_1	1278073.MYSTI_04398	5.068e-68	241.0	COG4305@1|root,COG4305@2|Bacteria,1MYW4@1224|Proteobacteria,434JK@68525|delta/epsilon subdivisions,2WYWV@28221|Deltaproteobacteria,2Z0TT@29|Myxococcales	28221|Deltaproteobacteria	G	Rare lipoprotein A (RlpA)-like double-psi beta-barrel	-	-	-	ko:K20628	-	-	-	-	ko00000	-	-	-	DPBB_1,Pollen_allerg_1
HKD2_k127_8949238_2	1192034.CAP_2178	4.294e-67	232.0	COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,42N8Y@68525|delta/epsilon subdivisions,2WIR7@28221|Deltaproteobacteria,2YTYX@29|Myxococcales	28221|Deltaproteobacteria	C	dihydrolipoamide dehydrogenase	pdhD	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
HKD2_k127_8950581_5	1192034.CAP_8968	1.382e-53	197.0	COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,42MN5@68525|delta/epsilon subdivisions,2WINN@28221|Deltaproteobacteria,2YU3A@29|Myxococcales	28221|Deltaproteobacteria	H	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen	glnD	-	2.7.7.59	ko:K00990	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	-	-	-	ACT,DUF294,GlnD_UR_UTase,GlnE,HD,NTP_transf_2
HKD2_k127_8950581_7	448385.sce3142	5.522e-39	158.0	COG0457@1|root,COG0457@2|Bacteria,1PEH7@1224|Proteobacteria,42TVC@68525|delta/epsilon subdivisions,2WSCX@28221|Deltaproteobacteria,2YZCB@29|Myxococcales	28221|Deltaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_14,TPR_16,TPR_2,TPR_4,TPR_6,TPR_8
HKD2_k127_8950581_4	1095767.CAHD01000224_gene2121	2.6e-56	214.0	COG0130@1|root,COG0130@2|Bacteria,2GJZK@201174|Actinobacteria,4F0NH@85016|Cellulomonadaceae	201174|Actinobacteria	J	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs	truB	GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016556,GO:0016853,GO:0016866,GO:0030312,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:1901360,GO:1990481	5.4.99.25	ko:K03177	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruB_C,TruB_C_2,TruB_N
HKD2_k127_8950581_3	502025.Hoch_3215	3.629e-100	353.0	COG0204@1|root,COG0204@2|Bacteria,1N01J@1224|Proteobacteria,42UM7@68525|delta/epsilon subdivisions,2WQN9@28221|Deltaproteobacteria,2Z3CW@29|Myxococcales	28221|Deltaproteobacteria	I	Phosphate acyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Acyltransferase
HKD2_k127_8950581_0	448385.sce4283	3.465e-131	429.0	COG0451@1|root,COG0451@2|Bacteria,1N8PG@1224|Proteobacteria,42UM2@68525|delta/epsilon subdivisions,2WR61@28221|Deltaproteobacteria,2YVAU@29|Myxococcales	28221|Deltaproteobacteria	GM	NAD dependent epimerase/dehydratase family	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
HKD2_k127_8950581_2	502025.Hoch_5887	6.071e-103	361.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,42RC9@68525|delta/epsilon subdivisions,2WN5U@28221|Deltaproteobacteria,2YWJ8@29|Myxococcales	28221|Deltaproteobacteria	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	DUF4388,PEGA,Pkinase
HKD2_k127_8950581_1	448385.sce3425	2.882e-126	414.0	COG0306@1|root,COG0306@2|Bacteria,1MVXK@1224|Proteobacteria,42Q5K@68525|delta/epsilon subdivisions,2X5HI@28221|Deltaproteobacteria,2Z35R@29|Myxococcales	28221|Deltaproteobacteria	P	Phosphate transporter family	-	-	-	ko:K03306	-	-	-	-	ko00000	2.A.20	-	-	PHO4
HKD2_k127_8950581_6	1254432.SCE1572_22110	1.534e-53	196.0	COG1392@1|root,COG1392@2|Bacteria,1R4SP@1224|Proteobacteria,42SPV@68525|delta/epsilon subdivisions,2WPTH@28221|Deltaproteobacteria,2Z0HM@29|Myxococcales	28221|Deltaproteobacteria	P	Protein of unknown function DUF47	-	-	-	ko:K07220	-	-	-	-	ko00000	-	-	-	PhoU_div
HKD2_k127_8953623_0	1192034.CAP_8138	1.1e-106	364.0	COG0823@1|root,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,PA14,PD40,PKD
HKD2_k127_8953623_3	987059.RBXJA2T_01310	2.362e-08	63.0	COG0745@1|root,COG0745@2|Bacteria,1MVCB@1224|Proteobacteria,2VQH1@28216|Betaproteobacteria,1KM67@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	Transcriptional regulatory protein, C terminal	creB	-	-	ko:K07663	ko02020,map02020	M00449	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
HKD2_k127_8953623_2	903818.KI912268_gene1569	1.116e-08	68.0	COG0382@1|root,COG0382@2|Bacteria	2|Bacteria	H	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate	ubiA	-	2.5.1.133,2.5.1.62	ko:K04040,ko:K20616	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R06284,R09067,R11514,R11517	RC00020	ko00000,ko00001,ko01000,ko01006	-	-	-	UbiA
HKD2_k127_8953623_1	391625.PPSIR1_28478	7.375e-38	150.0	COG0607@1|root,COG3258@1|root,COG0607@2|Bacteria,COG3258@2|Bacteria	2|Bacteria	C	Cytochrome c	soxA	GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005507,GO:0005515,GO:0005575,GO:0005623,GO:0006091,GO:0006464,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0016491,GO:0016667,GO:0016669,GO:0016740,GO:0016782,GO:0016783,GO:0018192,GO:0018193,GO:0018198,GO:0018307,GO:0019417,GO:0019538,GO:0020037,GO:0022900,GO:0036211,GO:0042597,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0046872,GO:0046906,GO:0046914,GO:0046982,GO:0046983,GO:0048037,GO:0055114,GO:0071704,GO:0097159,GO:0098822,GO:1901363,GO:1901564	1.8.2.2	ko:K00406,ko:K03889,ko:K17222,ko:K19713	ko00190,ko00920,ko01100,ko01120,ko02020,map00190,map00920,map01100,map01120,map02020	M00151,M00156,M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	Cytochrome_CBB3,Rhodanese
HKD2_k127_8957297_3	272123.Anacy_4754	3.473e-23	100.0	COG0459@1|root,COG0459@2|Bacteria,1G25A@1117|Cyanobacteria,1HIZU@1161|Nostocales	1117|Cyanobacteria	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL2	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0016465,GO:0032991,GO:0044183,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051082,GO:0061077,GO:0101031,GO:1990220	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
HKD2_k127_8957297_2	1192034.CAP_3841	7.839e-72	249.0	COG0664@1|root,COG0664@2|Bacteria,1NHNS@1224|Proteobacteria,42X3Y@68525|delta/epsilon subdivisions,2WT4M@28221|Deltaproteobacteria,2YVRK@29|Myxococcales	28221|Deltaproteobacteria	K	cyclic nucleotide-binding	-	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	cNMP_binding
HKD2_k127_8957297_0	448385.sce2783	6.534e-114	382.0	COG1234@1|root,COG1234@2|Bacteria,1QU4B@1224|Proteobacteria,42SHU@68525|delta/epsilon subdivisions,2WPGG@28221|Deltaproteobacteria,2YWV3@29|Myxococcales	28221|Deltaproteobacteria	S	cAMP phosphodiesterases class-II	-	-	3.1.4.17	ko:K01120	ko00230,map00230	-	R00191,R01234	RC00296	ko00000,ko00001,ko01000	-	-	-	Lactamase_B_2,PDEase_II
HKD2_k127_8957297_1	391625.PPSIR1_34218	5.287e-106	367.0	COG3973@1|root,COG3973@2|Bacteria,1P638@1224|Proteobacteria,42MXR@68525|delta/epsilon subdivisions,2WK1Z@28221|Deltaproteobacteria,2Z32G@29|Myxococcales	28221|Deltaproteobacteria	L	DNA helicase	-	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AAA_19,UvrD_C_2
HKD2_k127_8959619_0	1254432.SCE1572_25620	1.056e-91	307.0	COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,42N6N@68525|delta/epsilon subdivisions,2WJ1W@28221|Deltaproteobacteria,2YUFG@29|Myxococcales	28221|Deltaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain	nuoF-2	-	1.6.5.3	ko:K00334,ko:K00335	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx,Complex1_51K,NADH_4Fe-4S,SLBB
HKD2_k127_8959619_2	1254432.SCE1572_25615	4.573e-41	159.0	COG0839@1|root,COG0839@2|Bacteria,1PJW9@1224|Proteobacteria,42V0F@68525|delta/epsilon subdivisions,2WS8G@28221|Deltaproteobacteria,2Z2ZK@29|Myxococcales	28221|Deltaproteobacteria	C	NADH-ubiquinone/plastoquinone oxidoreductase chain 6	nuoJ	-	1.6.5.3	ko:K00339	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q3
HKD2_k127_8959619_3	1192034.CAP_6529	9.498e-29	126.0	COG0713@1|root,COG0713@2|Bacteria,1RH0S@1224|Proteobacteria,42VAT@68525|delta/epsilon subdivisions,2WRE5@28221|Deltaproteobacteria,2YVNJ@29|Myxococcales	28221|Deltaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoK	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0030964,GO:0032991,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0072521,GO:0098796,GO:0098797,GO:0098803,GO:1901135,GO:1901360,GO:1901564,GO:1902494,GO:1990204	1.6.5.3	ko:K00340	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q2
HKD2_k127_8959619_1	448385.sce4220	2.737e-51	186.0	COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,42KZE@68525|delta/epsilon subdivisions,2WIPT@28221|Deltaproteobacteria,2YWE3@29|Myxococcales	28221|Deltaproteobacteria	CP	NADH-Ubiquinone oxidoreductase (complex I) chain 5 L domain protein	nuoL-1	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_C,Proton_antipo_M,Proton_antipo_N
HKD2_k127_8963818_1	1254432.SCE1572_14575	1.146e-41	157.0	COG1595@1|root,COG1595@2|Bacteria,1QAB8@1224|Proteobacteria,434YB@68525|delta/epsilon subdivisions,2WZ98@28221|Deltaproteobacteria,2Z1MI@29|Myxococcales	28221|Deltaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD2_k127_8963818_0	448385.sce3738	2.671e-143	461.0	COG0042@1|root,COG0042@2|Bacteria,1MV5V@1224|Proteobacteria,42N3M@68525|delta/epsilon subdivisions,2WKM7@28221|Deltaproteobacteria,2YVBI@29|Myxococcales	28221|Deltaproteobacteria	H	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines	nifR3	-	-	ko:K05540	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Dus
HKD2_k127_8963818_4	322710.Avin_39560	4.784e-20	92.0	COG0228@1|root,COG0228@2|Bacteria,1MZCT@1224|Proteobacteria,1S8RT@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	Belongs to the bacterial ribosomal protein bS16 family	rpsP	GO:0000028,GO:0000217,GO:0000400,GO:0003674,GO:0003676,GO:0003677,GO:0003735,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006259,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016787,GO:0016788,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02959	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S16
HKD2_k127_8963818_2	880072.Desac_0744	1.53e-22	100.0	COG1837@1|root,COG1837@2|Bacteria,1N7IX@1224|Proteobacteria,42TXI@68525|delta/epsilon subdivisions,2WQBS@28221|Deltaproteobacteria,2MQIW@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	KH domain	-	-	-	ko:K06960	-	-	-	-	ko00000	-	-	-	KH_4
HKD2_k127_8964035_1	448385.sce1276	1.847e-129	419.0	COG2357@1|root,COG2357@2|Bacteria,1QYWE@1224|Proteobacteria,432GG@68525|delta/epsilon subdivisions,2WY52@28221|Deltaproteobacteria,2Z0Y8@29|Myxococcales	28221|Deltaproteobacteria	S	RelA SpoT domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8964035_4	1123301.KB904188_gene1154	8.899e-34	142.0	COG0726@1|root,COG0726@2|Bacteria,1V6DN@1239|Firmicutes,4HEPH@91061|Bacilli	91061|Bacilli	G	deacetylase	pgdA	-	3.5.1.104	ko:K22278	-	-	-	-	ko00000,ko01000	-	-	-	Polysacc_deac_1
HKD2_k127_8964035_3	1254432.SCE1572_48495	2.291e-68	243.0	COG0526@1|root,COG0526@2|Bacteria	2|Bacteria	CO	cell redox homeostasis	resA	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,TraF
HKD2_k127_8964035_5	1121861.KB899914_gene2092	5.056e-29	121.0	COG4319@1|root,COG4319@2|Bacteria,1MZK9@1224|Proteobacteria,2U5AR@28211|Alphaproteobacteria,2JTW8@204441|Rhodospirillales	204441|Rhodospirillales	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_3
HKD2_k127_8964035_0	1254432.SCE1572_48485	2.07e-210	667.0	COG1032@1|root,COG1032@2|Bacteria,1MU15@1224|Proteobacteria,42N12@68525|delta/epsilon subdivisions,2WK0X@28221|Deltaproteobacteria,2YUG3@29|Myxococcales	28221|Deltaproteobacteria	C	Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
HKD2_k127_8964035_2	448385.sce0056	1.166e-69	248.0	COG0402@1|root,COG2374@1|root,COG0402@2|Bacteria,COG2374@2|Bacteria,1NFUA@1224|Proteobacteria,433MB@68525|delta/epsilon subdivisions,2WXJF@28221|Deltaproteobacteria,2YUGP@29|Myxococcales	28221|Deltaproteobacteria	F	Lamin Tail Domain	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1,DUF4215,LTD,TSP_3
HKD2_k127_8970063_0	1254432.SCE1572_03585	2.111e-64	233.0	COG0760@1|root,COG1651@1|root,COG0760@2|Bacteria,COG1651@2|Bacteria,1RKYF@1224|Proteobacteria,42T64@68525|delta/epsilon subdivisions,2WP82@28221|Deltaproteobacteria,2YU4W@29|Myxococcales	28221|Deltaproteobacteria	O	Thioredoxin	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_4
HKD2_k127_8970063_2	448385.sce7479	7.717e-15	84.0	28ZS2@1|root,2ZMGV@2|Bacteria,1Q9PN@1224|Proteobacteria,434I5@68525|delta/epsilon subdivisions,2X8WM@28221|Deltaproteobacteria,2Z0QQ@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	CAP
HKD2_k127_8970063_1	1304865.JAGF01000001_gene1436	2.296e-28	115.0	COG2271@1|root,COG2271@2|Bacteria	2|Bacteria	G	transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD2_k127_8971681_6	1192034.CAP_7184	2.4e-103	346.0	COG1136@1|root,COG1136@2|Bacteria,1MVSQ@1224|Proteobacteria,42QNS@68525|delta/epsilon subdivisions,2WMSN@28221|Deltaproteobacteria,2YURX@29|Myxococcales	28221|Deltaproteobacteria	V	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner	lolD	-	-	ko:K09810	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.125	-	-	ABC_tran
HKD2_k127_8971681_13	1192034.CAP_7491	5.143e-32	144.0	COG1075@1|root,COG1075@2|Bacteria	2|Bacteria	KLT	acetyltransferases and hydrolases with the alpha beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6,Lipase_2
HKD2_k127_8971681_7	1254432.SCE1572_46690	1.354e-91	322.0	2A4BQ@1|root,30SXD@2|Bacteria,1PCFN@1224|Proteobacteria,438EV@68525|delta/epsilon subdivisions,2WYPE@28221|Deltaproteobacteria,2YWSY@29|Myxococcales	28221|Deltaproteobacteria	S	IgGFc binding protein	-	-	-	-	-	-	-	-	-	-	-	-	IgGFc_binding
HKD2_k127_8971681_3	1254432.SCE1572_34165	2.073e-107	370.0	COG0515@1|root,COG0515@2|Bacteria	1254432.SCE1572_34165|-	KLT	protein kinase activity	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	-
HKD2_k127_8971681_11	404589.Anae109_0580	1.102e-52	194.0	COG3795@1|root,COG3795@2|Bacteria,1Q42B@1224|Proteobacteria,439VS@68525|delta/epsilon subdivisions,2X59V@28221|Deltaproteobacteria,2Z0B4@29|Myxococcales	28221|Deltaproteobacteria	S	YCII-related domain	-	-	-	-	-	-	-	-	-	-	-	-	YCII
HKD2_k127_8971681_4	1242864.D187_004509	3.718e-105	368.0	COG0642@1|root,COG3852@1|root,COG2205@2|Bacteria,COG3852@2|Bacteria,1MVN6@1224|Proteobacteria,43BPS@68525|delta/epsilon subdivisions,2X710@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Signal transduction histidine kinase, nitrogen specific	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
HKD2_k127_8971681_0	1192034.CAP_4725	1.506e-156	520.0	COG0457@1|root,COG0515@1|root,COG5616@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG5616@2|Bacteria,1MV1P@1224|Proteobacteria,42PPB@68525|delta/epsilon subdivisions,2X5YN@28221|Deltaproteobacteria,2YUEJ@29|Myxococcales	28221|Deltaproteobacteria	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_10,TPR_12
HKD2_k127_8971681_10	266835.14026379	8.027e-66	247.0	COG2890@1|root,COG2890@2|Bacteria,1MX8Q@1224|Proteobacteria,2TSNS@28211|Alphaproteobacteria,43MXZ@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	J	Belongs to the protein N5-glutamine methyltransferase family	-	-	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS
HKD2_k127_8971681_12	1502851.FG93_02412	2.473e-51	201.0	COG5476@1|root,COG5476@2|Bacteria,1MX4P@1224|Proteobacteria,2TS1C@28211|Alphaproteobacteria,3JRKN@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Involved in peptidolytic degradation of cyclic heptapeptide hepatotoxin microcystin (MC)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1485,MlrC_C
HKD2_k127_8971681_19	390989.JOEG01000006_gene901	2.742e-05	54.0	COG1309@1|root,COG1309@2|Bacteria,2GJZT@201174|Actinobacteria,4DFGA@85008|Micromonosporales	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
HKD2_k127_8971681_16	1254432.SCE1572_20885	1.341e-19	99.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	hrpL	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD2_k127_8971681_2	1144275.COCOR_05708	1.458e-121	406.0	COG0019@1|root,COG0019@2|Bacteria,1MUA6@1224|Proteobacteria,42KZH@68525|delta/epsilon subdivisions,2WIRM@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine	-	-	4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
HKD2_k127_8971681_17	1121272.KB903272_gene121	3.557e-10	70.0	2ART5@1|root,31H4G@2|Bacteria,2I83W@201174|Actinobacteria,4DIX7@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8971681_15	338963.Pcar_1532	4.342e-26	119.0	2ART5@1|root,336GI@2|Bacteria,1R39N@1224|Proteobacteria,4322V@68525|delta/epsilon subdivisions,2WWQQ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8971681_5	1192034.CAP_4147	7.831e-105	364.0	COG1045@1|root,COG1045@2|Bacteria,1MVFX@1224|Proteobacteria,42MND@68525|delta/epsilon subdivisions,2WJC3@28221|Deltaproteobacteria,2YZ9D@29|Myxococcales	28221|Deltaproteobacteria	E	serine O-acetyltransferase	cysE	-	2.3.1.30	ko:K00640	ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111	M00021	R00586	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,SATase_N
HKD2_k127_8971681_1	448385.sce3525	1.769e-147	475.0	COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,42N1R@68525|delta/epsilon subdivisions,2WJ7R@28221|Deltaproteobacteria,2YWJD@29|Myxococcales	28221|Deltaproteobacteria	E	Belongs to the cysteine synthase cystathionine beta- synthase family	-	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HKD2_k127_8971681_20	237727.NAP1_01860	0.0007271	52.0	COG5653@1|root,COG5653@2|Bacteria,1N3Z9@1224|Proteobacteria,2TRT5@28211|Alphaproteobacteria,2K1RW@204457|Sphingomonadales	204457|Sphingomonadales	M	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_6
HKD2_k127_8971681_8	1297742.A176_02240	1.483e-88	314.0	COG3919@1|root,COG3919@2|Bacteria	2|Bacteria	E	ATP-grasp	yxbA	-	6.3.1.12	ko:K17810	-	-	-	-	ko00000,ko01000	-	-	-	CPSase_L_D2
HKD2_k127_8971681_18	1089545.KB913037_gene1180	2.907e-06	54.0	COG3250@1|root,COG3250@2|Bacteria,2I3FI@201174|Actinobacteria,4EDX1@85010|Pseudonocardiales	201174|Actinobacteria	G	Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain	-	-	3.2.1.40	ko:K05989	-	-	-	-	ko00000,ko01000	-	-	-	Bac_rhamnosid,Bac_rhamnosid6H,Bac_rhamnosid_C,Bac_rhamnosid_N
HKD2_k127_8972103_0	1192034.CAP_8216	4.503e-142	475.0	COG0366@1|root,COG0366@2|Bacteria	2|Bacteria	G	hydrolase activity, hydrolyzing O-glycosyl compounds	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase
HKD2_k127_8972103_1	1192034.CAP_7108	2.967e-48	184.0	2A4RR@1|root,30TD5@2|Bacteria,1PD62@1224|Proteobacteria,435EI@68525|delta/epsilon subdivisions,2WZS8@28221|Deltaproteobacteria,2Z2MR@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8975897_0	1192034.CAP_0180	3.842e-200	636.0	COG0457@1|root,COG2956@1|root,COG3071@1|root,COG5373@1|root,COG0457@2|Bacteria,COG2956@2|Bacteria,COG3071@2|Bacteria,COG5373@2|Bacteria,1MVIW@1224|Proteobacteria,437VP@68525|delta/epsilon subdivisions,2WWNT@28221|Deltaproteobacteria,2YUC4@29|Myxococcales	28221|Deltaproteobacteria	G	repeat protein	agmK	-	-	-	-	-	-	-	-	-	-	-	TPR_19,TPR_6,TPR_7,TPR_8
HKD2_k127_8978944_13	448385.sce8943	1.976e-43	173.0	COG2207@1|root,COG2207@2|Bacteria,1MX23@1224|Proteobacteria,42UHJ@68525|delta/epsilon subdivisions,2WT4S@28221|Deltaproteobacteria,2YUXZ@29|Myxococcales	28221|Deltaproteobacteria	K	Arabinose-binding domain of AraC transcription regulator, N-term	oruR2	-	-	-	-	-	-	-	-	-	-	-	Arabinose_bd,HTH_18
HKD2_k127_8978944_5	1254432.SCE1572_34415	3.444e-104	353.0	COG1086@1|root,COG1215@1|root,COG1086@2|Bacteria,COG1215@2|Bacteria,1R988@1224|Proteobacteria,42QGX@68525|delta/epsilon subdivisions,2WJPU@28221|Deltaproteobacteria,2YV0M@29|Myxococcales	28221|Deltaproteobacteria	M	Glycosyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HKD2_k127_8978944_16	2002.JOEQ01000004_gene3077	1.274e-26	115.0	2BVXS@1|root,334C2@2|Bacteria,2GSH2@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8978944_10	622637.KE124774_gene462	1.018e-58	222.0	COG5361@1|root,COG5361@2|Bacteria,1MWTW@1224|Proteobacteria,2TUR1@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1254)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1214,DUF1254
HKD2_k127_8978944_1	1244869.H261_06801	7.002e-186	614.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2TR3P@28211|Alphaproteobacteria,2JRE7@204441|Rhodospirillales	204441|Rhodospirillales	I	COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
HKD2_k127_8978944_8	502025.Hoch_4372	1.547e-74	259.0	COG1073@1|root,COG1073@2|Bacteria,1NX86@1224|Proteobacteria,42QXW@68525|delta/epsilon subdivisions,2WN43@28221|Deltaproteobacteria,2YZ5P@29|Myxococcales	28221|Deltaproteobacteria	S	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
HKD2_k127_8978944_12	1123258.AQXZ01000018_gene963	3.73e-44	175.0	COG3568@1|root,COG3568@2|Bacteria,2IGGC@201174|Actinobacteria	201174|Actinobacteria	S	Endonuclease/Exonuclease/phosphatase family	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
HKD2_k127_8978944_4	391625.PPSIR1_13810	1.362e-131	436.0	COG0604@1|root,COG0604@2|Bacteria,1MWRK@1224|Proteobacteria	1224|Proteobacteria	C	COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases	MA20_32380	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
HKD2_k127_8978944_20	1192034.CAP_1591	2.273e-14	78.0	2BU8D@1|root,32PHV@2|Bacteria,1NANB@1224|Proteobacteria,433N8@68525|delta/epsilon subdivisions,2WXKZ@28221|Deltaproteobacteria,2YW2P@29|Myxococcales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF4920)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4920
HKD2_k127_8978944_2	502025.Hoch_4100	3.089e-183	591.0	COG1232@1|root,COG1232@2|Bacteria,1MX35@1224|Proteobacteria,42NE7@68525|delta/epsilon subdivisions,2WJ77@28221|Deltaproteobacteria,2Z35P@29|Myxococcales	28221|Deltaproteobacteria	H	Flavin containing amine oxidoreductase	-	-	5.4.99.9	ko:K01854	ko00052,ko00520,map00052,map00520	-	R00505,R09009	RC00317,RC02396	ko00000,ko00001,ko01000	-	-	-	Amino_oxidase,NAD_binding_8
HKD2_k127_8978944_15	1331060.RLDS_09840	9.451e-32	143.0	COG4262@1|root,COG4262@2|Bacteria,1P1G3@1224|Proteobacteria,2TQSR@28211|Alphaproteobacteria,2K07Q@204457|Sphingomonadales	204457|Sphingomonadales	S	Spermidine synthase	-	-	-	-	-	-	-	-	-	-	-	-	Spermine_synth
HKD2_k127_8978944_3	1173028.ANKO01000014_gene1055	1.541e-138	476.0	COG0642@1|root,COG0784@1|root,COG5002@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,COG5002@2|Bacteria,1G4X8@1117|Cyanobacteria	1117|Cyanobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg
HKD2_k127_8978944_9	1111479.AXAR01000009_gene2402	1.459e-70	269.0	COG3391@1|root,COG3511@1|root,COG3391@2|Bacteria,COG3511@2|Bacteria,1V255@1239|Firmicutes,4HFUF@91061|Bacilli	91061|Bacilli	M	40-residue YVTN family beta-propeller repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	Collagen,Cytochrom_D1,Lactonase,Phosphoesterase
HKD2_k127_8978944_14	1288083.AUKR01000003_gene3558	4.941e-41	159.0	COG2030@1|root,COG2030@2|Bacteria,2IHRG@201174|Actinobacteria	201174|Actinobacteria	I	dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydratas
HKD2_k127_8978944_17	661367.LLO_1083	1.943e-21	110.0	COG4447@1|root,COG4447@2|Bacteria,1R1E3@1224|Proteobacteria	1224|Proteobacteria	DZ	regulator of chromosome condensation, RCC1	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8978944_6	926566.Terro_1937	6.805e-101	353.0	COG2374@1|root,COG2374@2|Bacteria,3Y6CB@57723|Acidobacteria,2JMEK@204432|Acidobacteriia	204432|Acidobacteriia	S	Endonuclease Exonuclease Phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8978944_18	1144275.COCOR_05928	3.399e-17	96.0	COG4447@1|root,COG4447@2|Bacteria,1PK4F@1224|Proteobacteria,437G7@68525|delta/epsilon subdivisions,2XA3A@28221|Deltaproteobacteria,2YVKV@29|Myxococcales	28221|Deltaproteobacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8978944_7	1192034.CAP_1743	3.141e-92	318.0	COG0515@1|root,COG0515@2|Bacteria	1192034.CAP_1743|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8978944_0	745776.DGo_CA2326	1.013e-194	640.0	COG1226@1|root,COG1226@2|Bacteria	2|Bacteria	P	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)	dMI1	-	3.1.4.46	ko:K01126,ko:K10716	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	Castor_Poll_mid,TrkA_N
HKD2_k127_8978944_11	211114.JOEF01000003_gene3098	1.071e-49	188.0	COG0840@1|root,2Z8BY@2|Bacteria,2IGSE@201174|Actinobacteria	201174|Actinobacteria	NT	Methyl-accepting Chemotaxis protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8980542_2	391625.PPSIR1_34397	9.899e-79	275.0	COG3425@1|root,COG3425@2|Bacteria,1MU4K@1224|Proteobacteria,42M1Q@68525|delta/epsilon subdivisions,2WKSA@28221|Deltaproteobacteria,2YUUR@29|Myxococcales	28221|Deltaproteobacteria	I	synthase	mvaS	-	2.3.3.10	ko:K01641	ko00072,ko00280,ko00650,ko00900,ko01100,ko01110,ko01130,map00072,map00280,map00650,map00900,map01100,map01110,map01130	M00088,M00095	R01978	RC00004,RC00503	ko00000,ko00001,ko00002,ko01000	-	-	-	HMG_CoA_synt_C,HMG_CoA_synt_N
HKD2_k127_8980542_5	391625.PPSIR1_34402	4.755e-37	149.0	COG1024@1|root,COG1024@2|Bacteria,1MVEC@1224|Proteobacteria,4385B@68525|delta/epsilon subdivisions,2X9XY@28221|Deltaproteobacteria,2YVU8@29|Myxococcales	28221|Deltaproteobacteria	I	enoyl-CoA hydratase	-	-	-	ko:K15312	-	-	-	-	ko00000,ko01008	-	-	-	ECH_1
HKD2_k127_8980542_4	391625.PPSIR1_34407	8.95e-56	211.0	COG1024@1|root,COG1024@2|Bacteria,1REDY@1224|Proteobacteria,4382P@68525|delta/epsilon subdivisions,2X3CR@28221|Deltaproteobacteria,2YVFY@29|Myxococcales	28221|Deltaproteobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	-	ko:K15313	-	-	-	-	ko00000,ko01008	-	-	-	ECH_1
HKD2_k127_8980542_3	1192124.LIG30_4274	1.055e-71	251.0	COG1028@1|root,COG1028@2|Bacteria,1NY7Y@1224|Proteobacteria	1224|Proteobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HKD2_k127_8980542_6	391625.PPSIR1_34417	2.161e-18	97.0	COG0236@1|root,COG0236@2|Bacteria,1NHZ1@1224|Proteobacteria,4326E@68525|delta/epsilon subdivisions,2WXRN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	IQ	Phosphopantetheine attachment site	-	-	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
HKD2_k127_8980542_1	391625.PPSIR1_34412	1.109e-79	275.0	COG1028@1|root,COG1028@2|Bacteria,1NY7Y@1224|Proteobacteria	1224|Proteobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HKD2_k127_8980542_0	1192034.CAP_6692	2.243e-119	392.0	COG0454@1|root,COG0456@2|Bacteria,1PMA3@1224|Proteobacteria,42PYX@68525|delta/epsilon subdivisions,2WKSE@28221|Deltaproteobacteria,2YUVH@29|Myxococcales	28221|Deltaproteobacteria	K	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8981216_3	378806.STAUR_1704	1.084e-13	72.0	COG1020@1|root,COG1020@2|Bacteria,1N7HY@1224|Proteobacteria,437XQ@68525|delta/epsilon subdivisions,2X37P@28221|Deltaproteobacteria,2YUR1@29|Myxococcales	28221|Deltaproteobacteria	Q	Protein of unknown function (DUF1298)	-	-	2.3.1.20	ko:K00635	ko00561,ko01100,map00561,map01100	M00089	R02251	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF1298,WES_acyltransf
HKD2_k127_8981216_2	1429046.RR21198_1177	2.765e-68	249.0	COG1752@1|root,COG1752@2|Bacteria,2HJ6N@201174|Actinobacteria,4G5HY@85025|Nocardiaceae	201174|Actinobacteria	S	Patatin-like phospholipase	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
HKD2_k127_8981216_1	1192034.CAP_4326	6.88e-92	316.0	COG0019@1|root,COG0019@2|Bacteria,1MUA6@1224|Proteobacteria,42KZH@68525|delta/epsilon subdivisions,2WIRM@28221|Deltaproteobacteria,2YUK3@29|Myxococcales	28221|Deltaproteobacteria	E	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine	lysA	-	4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
HKD2_k127_8981216_0	448385.sce4540	4.108e-121	400.0	COG0469@1|root,COG0469@2|Bacteria,1MU21@1224|Proteobacteria,42N30@68525|delta/epsilon subdivisions,2WJSW@28221|Deltaproteobacteria,2YUEU@29|Myxococcales	28221|Deltaproteobacteria	G	Belongs to the pyruvate kinase family	pyk	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PK,PK_C
HKD2_k127_8983416_2	502025.Hoch_4905	1.216e-52	195.0	COG0515@1|root,COG0515@2|Bacteria	502025.Hoch_4905|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8983416_0	502025.Hoch_4906	1.665e-73	266.0	COG0515@1|root,COG0515@2|Bacteria	502025.Hoch_4906|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8983416_1	1242864.D187_008071	2.195e-63	225.0	COG3591@1|root,COG3591@2|Bacteria,1MX71@1224|Proteobacteria	1224|Proteobacteria	E	Peptidase S46	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S46
HKD2_k127_8984796_9	502025.Hoch_3329	1.119e-10	62.0	COG1273@1|root,COG1273@2|Bacteria,1N4UX@1224|Proteobacteria,42RD5@68525|delta/epsilon subdivisions,2WMZ1@28221|Deltaproteobacteria,2YWME@29|Myxococcales	28221|Deltaproteobacteria	L	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD	ku	-	-	ko:K10979	ko03450,map03450	-	-	-	ko00000,ko00001,ko03400	-	-	-	Ku
HKD2_k127_8984796_7	1192034.CAP_1429	2.918e-34	136.0	COG1273@1|root,COG1273@2|Bacteria,1N4UX@1224|Proteobacteria,42RD5@68525|delta/epsilon subdivisions,2WMZ1@28221|Deltaproteobacteria,2YWME@29|Myxococcales	28221|Deltaproteobacteria	L	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD	ku	-	-	ko:K10979	ko03450,map03450	-	-	-	ko00000,ko00001,ko03400	-	-	-	Ku
HKD2_k127_8984796_1	644283.Micau_3453	1.386e-74	280.0	COG3831@1|root,COG3831@2|Bacteria,2HIEQ@201174|Actinobacteria,4D9WJ@85008|Micromonosporales	201174|Actinobacteria	S	Domain of unknown function (DUF4132)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4132,WGR
HKD2_k127_8984796_10	1270196.JCKI01000001_gene4031	0.0001634	55.0	COG0793@1|root,COG0793@2|Bacteria,4NEFX@976|Bacteroidetes,1IY6Q@117747|Sphingobacteriia	976|Bacteroidetes	M	Peptidase family S41	-	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S41,Tricorn_C1
HKD2_k127_8984796_2	1192034.CAP_1473	8.176e-71	264.0	COG0657@1|root,COG0657@2|Bacteria,1MVRE@1224|Proteobacteria,42XSE@68525|delta/epsilon subdivisions,2WTGG@28221|Deltaproteobacteria,2YYH0@29|Myxococcales	28221|Deltaproteobacteria	I	Pectinacetylesterase	-	-	-	-	-	-	-	-	-	-	-	-	PAE
HKD2_k127_8984796_0	448385.sce6078	7.842e-98	340.0	COG1398@1|root,COG1398@2|Bacteria,1Q353@1224|Proteobacteria,43069@68525|delta/epsilon subdivisions,2WVDR@28221|Deltaproteobacteria,2YXY2@29|Myxococcales	28221|Deltaproteobacteria	I	fatty acid desaturase	-	-	1.14.19.1	ko:K00507	ko01040,ko01212,ko03320,ko04152,ko04212,map01040,map01212,map03320,map04152,map04212	-	R02222	RC00917	ko00000,ko00001,ko01000,ko01004	-	-	-	FA_desaturase
HKD2_k127_8984796_3	1449346.JQMO01000003_gene6591	3.513e-68	248.0	COG3831@1|root,COG3831@2|Bacteria,2HIEQ@201174|Actinobacteria,2M4DS@2063|Kitasatospora	201174|Actinobacteria	S	Proposed nucleic acid binding domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4132,WGR
HKD2_k127_8984796_6	1254432.SCE1572_35230	8.943e-44	178.0	COG0566@1|root,COG0566@2|Bacteria	2|Bacteria	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family	trmH	-	2.1.1.185,2.1.1.34	ko:K00556,ko:K03218,ko:K03437	-	-	-	-	ko00000,ko01000,ko03009,ko03016	-	-	-	SpoU_methylase
HKD2_k127_8984796_4	246197.MXAN_6790	6.303e-54	198.0	COG0625@1|root,COG0625@2|Bacteria,1QA0M@1224|Proteobacteria,434R5@68525|delta/epsilon subdivisions,2WZ2A@28221|Deltaproteobacteria,2Z169@29|Myxococcales	28221|Deltaproteobacteria	O	Glutathione S-transferase, N-terminal domain	-	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C_2,GST_N_3
HKD2_k127_8984796_11	1217720.ALOX01000076_gene471	0.0008031	52.0	COG3391@1|root,COG3391@2|Bacteria,1MXBS@1224|Proteobacteria,2U4BC@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8984796_5	448385.sce0838	8.598e-46	166.0	COG0048@1|root,COG0048@2|Bacteria,1RCWY@1224|Proteobacteria,42RDQ@68525|delta/epsilon subdivisions,2WND8@28221|Deltaproteobacteria,2YV8E@29|Myxococcales	28221|Deltaproteobacteria	J	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit	rpsL	-	-	ko:K02950	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosom_S12_S23
HKD2_k127_8985083_17	485913.Krac_12195	7.494e-14	74.0	COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,2G65G@200795|Chloroflexi	200795|Chloroflexi	I	3-hydroxyacyl-CoA dehydrogenase domain protein	-	-	1.1.1.35	ko:K07516	ko00071,ko00362,ko00650,ko01100,ko01120,ko01200,ko01212,map00071,map00362,map00650,map01100,map01120,map01200,map01212	M00087	R01975,R04737,R04739,R04741,R04743,R04745,R04748,R05305	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000	-	-	-	3HCDH,3HCDH_N,ECH_1,ECH_2
HKD2_k127_8985083_3	1192034.CAP_3945	9.764e-124	422.0	COG2124@1|root,COG2124@2|Bacteria,1MV75@1224|Proteobacteria,438QR@68525|delta/epsilon subdivisions,2X3Y0@28221|Deltaproteobacteria,2YXIR@29|Myxococcales	28221|Deltaproteobacteria	C	Cytochrome P450	-	-	-	-	-	-	-	-	-	-	-	-	p450
HKD2_k127_8985083_8	246197.MXAN_1568	4.936e-66	249.0	COG1540@1|root,COG2049@1|root,COG1540@2|Bacteria,COG2049@2|Bacteria,1MUYV@1224|Proteobacteria,42QNE@68525|delta/epsilon subdivisions,2WMT3@28221|Deltaproteobacteria,2YV2W@29|Myxococcales	28221|Deltaproteobacteria	E	LamB/YcsF family	-	-	-	ko:K07160	-	-	-	-	ko00000	-	-	-	CT_C_D,LamB_YcsF
HKD2_k127_8985083_13	1242864.D187_004943	9.129e-37	155.0	COG1540@1|root,COG2049@1|root,COG1540@2|Bacteria,COG2049@2|Bacteria,1MUYV@1224|Proteobacteria,42QNE@68525|delta/epsilon subdivisions,2WMT3@28221|Deltaproteobacteria,2YV2W@29|Myxococcales	28221|Deltaproteobacteria	E	LamB/YcsF family	-	-	-	ko:K07160	-	-	-	-	ko00000	-	-	-	CT_C_D,LamB_YcsF
HKD2_k127_8985083_15	2045.KR76_10645	1.155e-29	135.0	COG1984@1|root,COG1984@2|Bacteria,2GITH@201174|Actinobacteria,4DQVB@85009|Propionibacteriales	201174|Actinobacteria	E	Allophanate hydrolase subunit 2	-	-	-	-	-	-	-	-	-	-	-	-	CT_A_B,CT_C_D
HKD2_k127_8985083_9	215803.DB30_5677	5.392e-55	198.0	COG1611@1|root,COG1611@2|Bacteria,1RD59@1224|Proteobacteria,43A8B@68525|delta/epsilon subdivisions,2X2PT@28221|Deltaproteobacteria,2YW8X@29|Myxococcales	28221|Deltaproteobacteria	S	Possible lysine decarboxylase	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
HKD2_k127_8985083_0	1254432.SCE1572_31500	5.176e-231	731.0	COG1297@1|root,COG1297@2|Bacteria,1N7SK@1224|Proteobacteria,42PMM@68525|delta/epsilon subdivisions,2X37C@28221|Deltaproteobacteria,2YUQZ@29|Myxococcales	28221|Deltaproteobacteria	S	OPT oligopeptide transporter protein	-	-	-	-	-	-	-	-	-	-	-	-	OPT
HKD2_k127_8985083_14	1163745.HCD_06370	6.209e-34	152.0	COG0790@1|root,COG0790@2|Bacteria,1MWPA@1224|Proteobacteria,42QE7@68525|delta/epsilon subdivisions,2YNGU@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	S	Sel1 repeat protein	-	-	-	ko:K07126	-	-	-	-	ko00000	-	-	-	Sel1
HKD2_k127_8985083_10	269799.Gmet_1773	1.034e-48	175.0	COG3169@1|root,COG3169@2|Bacteria,1RHBQ@1224|Proteobacteria,42SES@68525|delta/epsilon subdivisions,2WQ9T@28221|Deltaproteobacteria,43SNM@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Putative member of DMT superfamily (DUF486)	-	-	-	ko:K09922	-	-	-	-	ko00000	-	-	-	DMT_6
HKD2_k127_8985083_5	448385.sce4615	6.418e-84	295.0	COG0515@1|root,COG0515@2|Bacteria	448385.sce4615|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8985083_16	1192034.CAP_4085	1.537e-26	122.0	COG4105@1|root,COG4105@2|Bacteria	2|Bacteria	S	cell envelope organization	bamD	-	-	ko:K05807,ko:K08309	-	-	-	-	ko00000,ko01000,ko01011,ko02000	1.B.33.1	GH23	-	YfiO
HKD2_k127_8985083_18	1306174.JODP01000010_gene7040	1.049e-11	74.0	COG1262@1|root,COG1595@1|root,COG1262@2|Bacteria,COG1595@2|Bacteria,2GJ21@201174|Actinobacteria	201174|Actinobacteria	K	belongs to the sigma-70 factor family	-	-	-	-	-	-	-	-	-	-	-	-	AbfB,DUF1566,Sigma70_r2
HKD2_k127_8985083_20	448385.sce3909	1.048e-05	57.0	COG1262@1|root,COG1262@2|Bacteria,1R0CJ@1224|Proteobacteria	1224|Proteobacteria	S	Protein of unknown function (DUF1566)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1566
HKD2_k127_8985083_4	1192034.CAP_7221	7.461e-91	306.0	29XGE@1|root,30J6W@2|Bacteria,1R0E6@1224|Proteobacteria,43CWN@68525|delta/epsilon subdivisions,2WUSC@28221|Deltaproteobacteria,2Z1N5@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8985083_12	290397.Adeh_2556	2.915e-43	176.0	COG1807@1|root,COG1807@2|Bacteria,1P6JE@1224|Proteobacteria,42QEZ@68525|delta/epsilon subdivisions,2WKYB@28221|Deltaproteobacteria,2YZA0@29|Myxococcales	28221|Deltaproteobacteria	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HKD2_k127_8985083_1	448385.sce3440	4.551e-180	593.0	COG1033@1|root,COG1033@2|Bacteria,1R0CG@1224|Proteobacteria,43CUX@68525|delta/epsilon subdivisions,2X9DC@28221|Deltaproteobacteria,2Z3JS@29|Myxococcales	28221|Deltaproteobacteria	S	MMPL family	-	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
HKD2_k127_8985083_6	350058.Mvan_5030	4.108e-82	294.0	COG2723@1|root,COG2723@2|Bacteria,2GJAF@201174|Actinobacteria,235G0@1762|Mycobacteriaceae	201174|Actinobacteria	G	Glycosyl hydrolase family 1	bglA	-	3.2.1.21	ko:K05350	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_1
HKD2_k127_8985083_21	1089550.ATTH01000001_gene1127	4.718e-05	57.0	2DBQR@1|root,2ZAG2@2|Bacteria,4NK84@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Collagen_bind_2
HKD2_k127_8985083_11	448385.sce6236	2.911e-48	179.0	COG1309@1|root,COG1309@2|Bacteria,1MYFS@1224|Proteobacteria,42T8F@68525|delta/epsilon subdivisions,2WPCH@28221|Deltaproteobacteria,2Z34T@29|Myxococcales	28221|Deltaproteobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
HKD2_k127_8985083_19	1463825.JNXC01000008_gene1192	6.882e-09	68.0	COG3408@1|root,COG3507@1|root,COG5492@1|root,COG3408@2|Bacteria,COG3507@2|Bacteria,COG5492@2|Bacteria,2GK37@201174|Actinobacteria,4DZQD@85010|Pseudonocardiales	201174|Actinobacteria	GN	Glycosyl hydrolases family 43	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_5,Big_4,Glyco_hydro_43,Laminin_G_3
HKD2_k127_8985083_7	1254432.SCE1572_37450	5.087e-67	233.0	COG1924@1|root,COG3580@1|root,COG1924@2|Bacteria,COG3580@2|Bacteria,1PKG6@1224|Proteobacteria,42MY4@68525|delta/epsilon subdivisions,2WJFI@28221|Deltaproteobacteria,2YVGM@29|Myxococcales	28221|Deltaproteobacteria	I	CoA-substrate-specific enzyme activase	-	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG,DUF2229,HGD-D
HKD2_k127_8985734_3	1144275.COCOR_07153	3.751e-27	122.0	COG3391@1|root,COG3391@2|Bacteria,1QX9W@1224|Proteobacteria,43C32@68525|delta/epsilon subdivisions,2X7DQ@28221|Deltaproteobacteria,2YVS2@29|Myxococcales	28221|Deltaproteobacteria	S	Stigma-specific protein, Stig1	-	-	-	-	-	-	-	-	-	-	-	-	Stig1
HKD2_k127_8985734_5	3659.XP_004161979.1	2.09e-07	63.0	2BN3S@1|root,2S1NG@2759|Eukaryota,37VHH@33090|Viridiplantae,3GJNP@35493|Streptophyta,4JU4W@91835|fabids	35493|Streptophyta	S	Stigma-specific protein, Stig1	-	-	-	-	-	-	-	-	-	-	-	-	Stig1
HKD2_k127_8985734_4	1144275.COCOR_07153	1.004e-21	108.0	COG3391@1|root,COG3391@2|Bacteria,1QX9W@1224|Proteobacteria,43C32@68525|delta/epsilon subdivisions,2X7DQ@28221|Deltaproteobacteria,2YVS2@29|Myxococcales	28221|Deltaproteobacteria	S	Stigma-specific protein, Stig1	-	-	-	-	-	-	-	-	-	-	-	-	Stig1
HKD2_k127_8985734_2	478741.JAFS01000001_gene1173	4.028e-32	143.0	COG3511@1|root,COG3511@2|Bacteria,46UZ7@74201|Verrucomicrobia,37GTU@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	M	Phosphoesterase family	-	-	3.1.4.3	ko:K01114	ko00562,ko00564,ko00565,ko01100,ko01110,ko02024,ko04919,map00562,map00564,map00565,map01100,map01110,map02024,map04919	-	R01312,R02027,R02052,R03332,R07381	RC00017,RC00425	ko00000,ko00001,ko01000,ko02042	-	-	-	Phosphoesterase
HKD2_k127_8985734_6	1045858.Bint_0194	3.539e-05	56.0	COG0308@1|root,COG0308@2|Bacteria	2|Bacteria	E	peptide catabolic process	-	-	3.4.11.2	ko:K01256	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M1
HKD2_k127_8985734_1	880073.Calab_1254	3.607e-82	294.0	COG2133@1|root,COG2866@1|root,COG2133@2|Bacteria,COG2866@2|Bacteria	2|Bacteria	E	metallocarboxypeptidase activity	manA5	-	3.2.1.51,3.2.1.78	ko:K01206,ko:K01218	ko00051,ko00511,ko02024,map00051,map00511,map02024	-	R01332	RC00467	ko00000,ko00001,ko01000,ko04147	-	GH26,GH29	-	Alpha_L_fucos,CHU_C,Glyco_hydro_26,PA14
HKD2_k127_8985734_0	1254432.SCE1572_48640	7.125e-218	702.0	COG2199@1|root,COG2203@1|root,COG2203@2|Bacteria,COG3706@2|Bacteria,1MZV7@1224|Proteobacteria,42PVX@68525|delta/epsilon subdivisions,2WIJ8@28221|Deltaproteobacteria,2Z2WU@29|Myxococcales	28221|Deltaproteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,GGDEF
HKD2_k127_898588_3	502025.Hoch_4905	2.177e-44	165.0	COG0515@1|root,COG0515@2|Bacteria	502025.Hoch_4905|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_898588_2	391625.PPSIR1_36092	2.42e-48	181.0	COG1225@1|root,COG1225@2|Bacteria,1RD4R@1224|Proteobacteria,43APU@68525|delta/epsilon subdivisions,2X63M@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	Redoxin	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
HKD2_k127_898588_1	1192034.CAP_7893	1.051e-145	488.0	COG2303@1|root,COG2303@2|Bacteria,1P9UF@1224|Proteobacteria	1224|Proteobacteria	E	oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GMC_oxred_C,GMC_oxred_N
HKD2_k127_898588_4	746697.Aeqsu_0750	1.641e-15	88.0	COG3209@1|root,COG3291@1|root,COG4935@1|root,COG3209@2|Bacteria,COG3291@2|Bacteria,COG4935@2|Bacteria,4NDZC@976|Bacteroidetes,1IJ8A@117743|Flavobacteriia	976|Bacteroidetes	G	Pkd domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,Gal_Lectin,Gly_rich,HYR,Laminin_G_3,PKD,SprB,TSP_3
HKD2_k127_898588_0	1192034.CAP_4161	3.385e-148	474.0	COG0148@1|root,COG0148@2|Bacteria,1MU1N@1224|Proteobacteria,42MS9@68525|delta/epsilon subdivisions,2WJMS@28221|Deltaproteobacteria,2YWXC@29|Myxococcales	28221|Deltaproteobacteria	F	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
HKD2_k127_8986302_10	1192034.CAP_4745	2.611e-10	69.0	COG4105@1|root,COG4105@2|Bacteria	2|Bacteria	S	cell envelope organization	bamD	-	-	ko:K05807,ko:K08309	-	-	-	-	ko00000,ko01000,ko01011,ko02000	1.B.33.1	GH23	-	YfiO
HKD2_k127_8986302_3	1192034.CAP_6921	1.115e-79	286.0	COG0515@1|root,COG0515@2|Bacteria,1PFJ6@1224|Proteobacteria,4340Z@68525|delta/epsilon subdivisions,2X4J2@28221|Deltaproteobacteria,2YZ45@29|Myxococcales	28221|Deltaproteobacteria	KLT	Protein kinase domain	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
HKD2_k127_8986302_5	448385.sce1469	8.081e-73	267.0	2A4SI@1|root,30TDY@2|Bacteria,1PD6V@1224|Proteobacteria,435EQ@68525|delta/epsilon subdivisions,2X98Q@28221|Deltaproteobacteria,2Z2N2@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8986302_1	1254432.SCE1572_37355	6.753e-118	391.0	COG1651@1|root,COG1651@2|Bacteria,1Q3GQ@1224|Proteobacteria,43994@68525|delta/epsilon subdivisions,2X4GG@28221|Deltaproteobacteria,2YYZ6@29|Myxococcales	28221|Deltaproteobacteria	O	Vitamin K epoxide reductase family	-	-	-	-	-	-	-	-	-	-	-	-	VKOR
HKD2_k127_8986302_2	1254432.SCE1572_37360	1.597e-88	304.0	COG2885@1|root,COG2885@2|Bacteria,1Q9RC@1224|Proteobacteria,434J9@68525|delta/epsilon subdivisions,2WYWG@28221|Deltaproteobacteria,2Z0SZ@29|Myxococcales	28221|Deltaproteobacteria	M	chlorophyll binding	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8986302_8	1254432.SCE1572_37365	8.58e-31	138.0	COG0526@1|root,COG0526@2|Bacteria,1QT4H@1224|Proteobacteria,4356V@68525|delta/epsilon subdivisions,2X96A@28221|Deltaproteobacteria,2Z26T@29|Myxococcales	28221|Deltaproteobacteria	CO	COG0526, thiol-disulfide isomerase and thioredoxins	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_8
HKD2_k127_8986302_7	448385.sce8329	6.481e-45	181.0	COG1716@1|root,COG1716@2|Bacteria,1Q8QY@1224|Proteobacteria,437GG@68525|delta/epsilon subdivisions,2X2P3@28221|Deltaproteobacteria,2Z08U@29|Myxococcales	28221|Deltaproteobacteria	T	FHA domain	-	-	-	-	-	-	-	-	-	-	-	-	FHA
HKD2_k127_8986302_9	1192034.CAP_4702	1.099e-20	106.0	2E2XW@1|root,32XYS@2|Bacteria,1N3ID@1224|Proteobacteria,42UFM@68525|delta/epsilon subdivisions,2WQKF@28221|Deltaproteobacteria,2YVPU@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8986302_6	1254432.SCE1572_18130	5.355e-67	234.0	COG0503@1|root,COG0503@2|Bacteria,1MVZ6@1224|Proteobacteria,42QSH@68525|delta/epsilon subdivisions,2WP5X@28221|Deltaproteobacteria,2YY5P@29|Myxococcales	28221|Deltaproteobacteria	F	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis	apt	-	2.4.2.7	ko:K00759	ko00230,ko01100,map00230,map01100	-	R00190,R01229,R04378	RC00063	ko00000,ko00001,ko01000,ko04147	-	-	-	Pribosyltran
HKD2_k127_8986302_4	1254432.SCE1572_18135	2.019e-74	261.0	COG0496@1|root,COG0496@2|Bacteria,1MVHE@1224|Proteobacteria,42N0I@68525|delta/epsilon subdivisions,2WMUX@28221|Deltaproteobacteria,2YVC8@29|Myxococcales	28221|Deltaproteobacteria	F	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates	surE	-	3.1.3.5	ko:K03787	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	SurE
HKD2_k127_8986302_0	886293.Sinac_5044	4.643e-136	456.0	COG1505@1|root,COG1505@2|Bacteria,2IXRJ@203682|Planctomycetes	203682|Planctomycetes	E	Prolyl oligopeptidase	-	-	3.4.21.26	ko:K01322	ko04614,map04614	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S9,Peptidase_S9_N
HKD2_k127_8986672_1	1192034.CAP_3447	3.593e-110	370.0	COG3146@1|root,COG3146@2|Bacteria,1MU35@1224|Proteobacteria,42RUS@68525|delta/epsilon subdivisions,2WNWT@28221|Deltaproteobacteria,2YWXA@29|Myxococcales	28221|Deltaproteobacteria	S	Peptidogalycan biosysnthesis/recognition	-	-	-	ko:K09919	-	-	-	-	ko00000	-	-	-	FemAB_like
HKD2_k127_8986672_2	502025.Hoch_5360	2.4e-77	269.0	COG0491@1|root,COG0491@2|Bacteria,1MU8Q@1224|Proteobacteria,42QST@68525|delta/epsilon subdivisions,2WMN8@28221|Deltaproteobacteria,2YZ74@29|Myxococcales	28221|Deltaproteobacteria	S	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid	gloB	-	3.1.2.6	ko:K01069	ko00620,map00620	-	R01736	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	HAGH_C,Lactamase_B
HKD2_k127_8986672_0	448385.sce3929	1.791e-129	435.0	COG3119@1|root,COG3119@2|Bacteria,1QZHU@1224|Proteobacteria,42PUM@68525|delta/epsilon subdivisions,2X7T5@28221|Deltaproteobacteria,2Z00V@29|Myxococcales	28221|Deltaproteobacteria	P	Sulfatase	-	-	3.1.6.6	ko:K01133	-	-	-	-	ko00000,ko01000	-	-	-	Cu-binding_MopE,Sulfatase
HKD2_k127_8986672_3	1192034.CAP_7010	3.428e-68	236.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,1MVIW@1224|Proteobacteria,437VP@68525|delta/epsilon subdivisions,2WWNT@28221|Deltaproteobacteria,2YUC4@29|Myxococcales	28221|Deltaproteobacteria	G	repeat protein	agmK	-	-	-	-	-	-	-	-	-	-	-	Pkinase,TPR_16,TPR_19,TPR_7,TPR_8
HKD2_k127_8994561_1	1192034.CAP_3373	4.977e-103	343.0	COG1804@1|root,COG1804@2|Bacteria,1MW1H@1224|Proteobacteria,42PNZ@68525|delta/epsilon subdivisions,2WM13@28221|Deltaproteobacteria,2YUDU@29|Myxococcales	28221|Deltaproteobacteria	C	CoA-transferase family III	-	-	5.1.99.4	ko:K01796	ko00120,ko01100,ko04146,map00120,map01100,map04146	M00104	R08734,R08739	RC02345	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_transf_3
HKD2_k127_8994561_3	1192034.CAP_3372	7.461e-56	209.0	COG2804@1|root,COG2804@2|Bacteria	2|Bacteria	NU	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB	-	-	-	ko:K02652	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE_N
HKD2_k127_8994561_0	448385.sce2470	5.303e-307	967.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,42Q67@68525|delta/epsilon subdivisions,2WKZ1@28221|Deltaproteobacteria,2YUQ6@29|Myxococcales	28221|Deltaproteobacteria	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	AAA_16,Pkinase,TPR_12,zinc_ribbon_2
HKD2_k127_8994561_2	1254432.SCE1572_14850	1.055e-56	201.0	COG4850@1|root,COG4850@2|Bacteria,1NYAE@1224|Proteobacteria,430HM@68525|delta/epsilon subdivisions,2WW1X@28221|Deltaproteobacteria,2YUT1@29|Myxococcales	28221|Deltaproteobacteria	S	conserved protein (DUF2183)	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8994561_4	1192034.CAP_3370	1.603e-44	168.0	COG4850@1|root,COG4850@2|Bacteria,1NYAE@1224|Proteobacteria,430HM@68525|delta/epsilon subdivisions,2WW1X@28221|Deltaproteobacteria,2YUT1@29|Myxococcales	28221|Deltaproteobacteria	S	conserved protein (DUF2183)	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8997101_0	391625.PPSIR1_05733	2.486e-168	548.0	COG3291@1|root,COG3291@2|Bacteria,1QEIS@1224|Proteobacteria,4389M@68525|delta/epsilon subdivisions,2X3J1@28221|Deltaproteobacteria,2YWAB@29|Myxococcales	28221|Deltaproteobacteria	S	IgGFc binding protein	-	-	-	-	-	-	-	-	-	-	-	-	IgGFc_binding
HKD2_k127_8997101_3	1121938.AUDY01000007_gene2501	0.0001116	51.0	2DR03@1|root,339MB@2|Bacteria,1VK6Y@1239|Firmicutes,4HR34@91061|Bacilli	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8997101_2	502025.Hoch_5122	8.028e-06	59.0	COG3215@1|root,COG3215@2|Bacteria,1QR4G@1224|Proteobacteria,4352F@68525|delta/epsilon subdivisions,2WZDD@28221|Deltaproteobacteria,2Z1W5@29|Myxococcales	28221|Deltaproteobacteria	NU	PilZ domain	-	-	-	-	-	-	-	-	-	-	-	-	PilZ
HKD2_k127_8997101_1	378806.STAUR_2012	1.165e-09	71.0	2DB7V@1|root,2Z7NX@2|Bacteria,1N9SI@1224|Proteobacteria,43ANT@68525|delta/epsilon subdivisions,2WTAF@28221|Deltaproteobacteria,2YYSS@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8999491_0	1254432.SCE1572_23080	3.53e-57	206.0	COG0388@1|root,COG0388@2|Bacteria	2|Bacteria	S	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	-	-	3.5.1.53	ko:K11206,ko:K12251	ko00330,ko01100,map00330,map01100	-	R01152	RC00096	ko00000,ko00001,ko01000	-	-	-	CN_hydrolase
HKD2_k127_8999491_1	1144275.COCOR_06948	4.44e-09	69.0	COG3055@1|root,COG3055@2|Bacteria,1QT4U@1224|Proteobacteria,437RQ@68525|delta/epsilon subdivisions,2X4KF@28221|Deltaproteobacteria,2YZ72@29|Myxococcales	28221|Deltaproteobacteria	E	M6 family metalloprotease domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9000022_1	479435.Kfla_3756	1.308e-139	451.0	COG1048@1|root,COG1048@2|Bacteria,2GJD5@201174|Actinobacteria,4DPP4@85009|Propionibacteriales	201174|Actinobacteria	C	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate	acnA	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003730,GO:0003824,GO:0003994,GO:0005488,GO:0005506,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005829,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0008198,GO:0009060,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0015980,GO:0016020,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019541,GO:0019679,GO:0019752,GO:0030312,GO:0030350,GO:0032787,GO:0040007,GO:0042221,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046459,GO:0046872,GO:0046914,GO:0047456,GO:0048037,GO:0050896,GO:0051536,GO:0051538,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:0071944,GO:0072350,GO:0097159,GO:1901363	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
HKD2_k127_9000022_2	1192034.CAP_0774	6.267e-84	296.0	COG0515@1|root,COG0515@2|Bacteria	1192034.CAP_0774|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9000022_4	1254432.SCE1572_33835	1.056e-52	198.0	COG1729@1|root,COG1729@2|Bacteria	2|Bacteria	S	protein trimerization	cpoB	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_6,TolA_bind_tri
HKD2_k127_9000022_3	446462.Amir_2434	9.375e-62	228.0	COG3868@1|root,COG3868@2|Bacteria,2GM86@201174|Actinobacteria,4E59Z@85010|Pseudonocardiales	201174|Actinobacteria	S	Glycoside-hydrolase family GH114	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_114
HKD2_k127_9000022_5	1254432.SCE1572_04885	1.489e-34	143.0	2F1NT@1|root,33UP3@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9000022_0	1254432.SCE1572_15395	0.0	1385.0	COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,42P3V@68525|delta/epsilon subdivisions,2WKWV@28221|Deltaproteobacteria,2YTVV@29|Myxococcales	28221|Deltaproteobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA1	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
HKD2_k127_9003007_2	448385.sce8555	4.214e-53	213.0	COG0515@1|root,COG0515@2|Bacteria	448385.sce8555|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9003007_3	1192034.CAP_8095	2.144e-25	118.0	COG2755@1|root,COG2755@2|Bacteria	2|Bacteria	E	lipolytic protein G-D-S-L family	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
HKD2_k127_9003007_1	1192034.CAP_1816	3.13e-73	258.0	COG1262@1|root,COG1262@2|Bacteria	2|Bacteria	T	PFAM Formylglycine-generating sulfatase enzyme	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase,SapC
HKD2_k127_9003007_0	215803.DB30_7410	2.666e-86	289.0	COG1573@1|root,COG1573@2|Bacteria,1MW91@1224|Proteobacteria,42SMW@68525|delta/epsilon subdivisions,2WPP1@28221|Deltaproteobacteria,2YUYP@29|Myxococcales	28221|Deltaproteobacteria	L	uracil-DNA glycosylase	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
HKD2_k127_9007650_3	1366050.N234_35550	6.992e-23	103.0	COG3652@1|root,COG3652@2|Bacteria,1RDPI@1224|Proteobacteria,2VRQA@28216|Betaproteobacteria,1K202@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Domain of unknown function (DUF4142)	-	-	-	ko:K08995	-	-	-	-	ko00000	-	-	-	DUF4142
HKD2_k127_9007650_1	439235.Dalk_2235	9.695e-72	249.0	COG0863@1|root,COG0863@2|Bacteria	2|Bacteria	L	N-4 methylation of cytosine	-	-	-	-	-	-	-	-	-	-	-	-	N6_N4_Mtase
HKD2_k127_9007650_0	391625.PPSIR1_41779	1.289e-81	292.0	COG3303@1|root,COG3303@2|Bacteria,1QX6Q@1224|Proteobacteria	1224|Proteobacteria	C	Cytochrome c554 and c-prime	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C552,Cytochrome_C554,Paired_CXXCH_1
HKD2_k127_9007650_4	1242864.D187_005409	1.583e-12	68.0	COG2124@1|root,COG2124@2|Bacteria,1MV75@1224|Proteobacteria,42NH2@68525|delta/epsilon subdivisions,2X33V@28221|Deltaproteobacteria,2YU3J@29|Myxococcales	28221|Deltaproteobacteria	C	cytochrome P450	-	-	-	-	-	-	-	-	-	-	-	-	p450
HKD2_k127_9012115_0	1192034.CAP_8968	6.089e-165	542.0	COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,42MN5@68525|delta/epsilon subdivisions,2WINN@28221|Deltaproteobacteria,2YU3A@29|Myxococcales	28221|Deltaproteobacteria	H	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen	glnD	-	2.7.7.59	ko:K00990	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	-	-	-	ACT,DUF294,GlnD_UR_UTase,GlnE,HD,NTP_transf_2
HKD2_k127_9012115_1	1123508.JH636450_gene7233	1.951e-08	65.0	2C9XM@1|root,32RQ6@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9012115_3	158190.SpiGrapes_2955	0.0003484	53.0	2A76W@1|root,30W2Y@2|Bacteria,2JADI@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9014159_3	709032.Sulku_0336	4.688e-10	68.0	COG1463@1|root,COG1463@2|Bacteria,1RFFS@1224|Proteobacteria,42P4P@68525|delta/epsilon subdivisions,2YNNZ@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	Q	MlaD protein	-	-	-	ko:K02067	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaD
HKD2_k127_9014159_1	391625.PPSIR1_21719	1.253e-72	269.0	COG3291@1|root,COG3291@2|Bacteria,1R7A1@1224|Proteobacteria,42Y4U@68525|delta/epsilon subdivisions,2WU72@28221|Deltaproteobacteria,2YZXW@29|Myxococcales	28221|Deltaproteobacteria	U	IgGFc binding protein	-	-	-	-	-	-	-	-	-	-	-	-	Big_1,IgGFc_binding
HKD2_k127_9014159_2	1254432.SCE1572_42990	9.314e-72	261.0	COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,42MNF@68525|delta/epsilon subdivisions,2WIYR@28221|Deltaproteobacteria,2YV41@29|Myxococcales	28221|Deltaproteobacteria	M	Peptidase family M23	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
HKD2_k127_9014159_0	1192034.CAP_7471	2.373e-86	291.0	COG0457@1|root,COG0457@2|Bacteria,1N5BD@1224|Proteobacteria,42U63@68525|delta/epsilon subdivisions,2WQUR@28221|Deltaproteobacteria,2YUQA@29|Myxococcales	28221|Deltaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_11,TPR_16,TPR_19,TPR_2,TPR_4,TPR_8
HKD2_k127_9022830_3	448385.sce7404	3.271e-29	127.0	COG0103@1|root,COG0103@2|Bacteria,1RD4A@1224|Proteobacteria,42SVI@68525|delta/epsilon subdivisions,2WP7T@28221|Deltaproteobacteria,2YV9P@29|Myxococcales	28221|Deltaproteobacteria	J	Belongs to the universal ribosomal protein uS9 family	rpsI	-	-	ko:K02996	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S9
HKD2_k127_9022830_1	1254432.SCE1572_43005	6.269e-62	216.0	COG0102@1|root,COG0102@2|Bacteria,1RA11@1224|Proteobacteria,42SD5@68525|delta/epsilon subdivisions,2WP5M@28221|Deltaproteobacteria,2YVJG@29|Myxococcales	28221|Deltaproteobacteria	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly	rplM	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02871	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13
HKD2_k127_9022830_2	1120985.AUMI01000015_gene1519	3.124e-37	155.0	COG1960@1|root,COG1960@2|Bacteria,1TP57@1239|Firmicutes,4H379@909932|Negativicutes	909932|Negativicutes	C	acyl-CoA dehydrogenase	acdA	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HKD2_k127_9022830_0	521098.Aaci_0144	7.272e-94	321.0	COG1960@1|root,COG1960@2|Bacteria,1UY8Z@1239|Firmicutes,4HD0N@91061|Bacilli	91061|Bacilli	I	Acyl-CoA dehydrogenase, N-terminal domain	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HKD2_k127_9025125_0	1254432.SCE1572_25340	2.413e-199	629.0	COG1032@1|root,COG1032@2|Bacteria,1MWR0@1224|Proteobacteria,42PFW@68525|delta/epsilon subdivisions,2WJ1N@28221|Deltaproteobacteria,2Z1PP@29|Myxococcales	28221|Deltaproteobacteria	C	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM,TPR_1
HKD2_k127_9025125_1	1254432.SCE1572_18060	1.912e-68	235.0	2A45U@1|root,30SQV@2|Bacteria,1PC2W@1224|Proteobacteria,4387T@68525|delta/epsilon subdivisions,2X3HK@28221|Deltaproteobacteria,2YW50@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9027318_0	246197.MXAN_2255	3.948e-65	247.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria	1224|Proteobacteria	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_12,zf-HC2
HKD2_k127_9027318_1	215803.DB30_4870	7.268e-14	72.0	COG3344@1|root,COG3344@2|Bacteria,1R44F@1224|Proteobacteria,42WGB@68525|delta/epsilon subdivisions,2WQ7V@28221|Deltaproteobacteria,2YY5R@29|Myxococcales	28221|Deltaproteobacteria	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	2.7.7.49	ko:K00986	-	-	-	-	ko00000,ko01000	-	-	-	RVT_1
HKD2_k127_9027548_0	1192034.CAP_5577	7.628e-135	447.0	2DV3U@1|root,33TXD@2|Bacteria,1NUW0@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9027548_1	1192034.CAP_5576	3.455e-85	289.0	COG1835@1|root,COG1835@2|Bacteria,1RFAU@1224|Proteobacteria,434WP@68525|delta/epsilon subdivisions,2WZ7M@28221|Deltaproteobacteria,2Z1I5@29|Myxococcales	28221|Deltaproteobacteria	I	Acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
HKD2_k127_9035601_1	1242864.D187_002244	9.163e-62	241.0	COG4715@1|root,COG4715@2|Bacteria,1R7Q0@1224|Proteobacteria	1224|Proteobacteria	S	Zinc finger, swim domain protein	yehQ	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	-	-	-	-	-	-	-	-	-	SWIM
HKD2_k127_9035601_0	446462.Amir_1885	9.187e-141	456.0	COG2304@1|root,COG2304@2|Bacteria,2I2ZD@201174|Actinobacteria	201174|Actinobacteria	S	VWA domain containing CoxE-like protein	-	-	-	-	-	-	-	-	-	-	-	-	VWA_CoxE
HKD2_k127_9035601_2	1242864.D187_002246	1.9e-49	184.0	COG2425@1|root,COG2425@2|Bacteria,1QV44@1224|Proteobacteria	1224|Proteobacteria	S	protein containing a von Willebrand factor type A (vWA) domain	yehM	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9037522_1	448385.sce2299	3.095e-69	240.0	COG0076@1|root,COG0076@2|Bacteria,1MWUX@1224|Proteobacteria,42MYA@68525|delta/epsilon subdivisions,2WKFB@28221|Deltaproteobacteria,2YWKI@29|Myxococcales	28221|Deltaproteobacteria	H	Pyridoxal-dependent decarboxylase conserved domain	-	-	-	-	-	-	-	-	-	-	-	-	Pyridoxal_deC
HKD2_k127_9037522_0	1192034.CAP_3718	9.965e-89	307.0	COG2833@1|root,COG2833@2|Bacteria,1MW0V@1224|Proteobacteria,42KZ6@68525|delta/epsilon subdivisions,2WVSN@28221|Deltaproteobacteria,2Z1YP@29|Myxococcales	28221|Deltaproteobacteria	F	Protein of unknown function (DUF455)	-	-	-	-	-	-	-	-	-	-	-	-	DUF455
HKD2_k127_9037522_3	247490.KSU1_C1370	6.679e-09	63.0	COG0443@1|root,COG0443@2|Bacteria,2IWWS@203682|Planctomycetes	203682|Planctomycetes	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
HKD2_k127_9037522_2	1068978.AMETH_0559	5.571e-31	124.0	2DR7K@1|root,33AJE@2|Bacteria,2GUKD@201174|Actinobacteria	201174|Actinobacteria	S	Cysteine-rich CPCC	-	-	-	-	-	-	-	-	-	-	-	-	Cys_rich_CPCC
HKD2_k127_9044290_0	1254432.SCE1572_11270	4.439e-45	182.0	2AGK2@1|root,316T7@2|Bacteria,1PXZH@1224|Proteobacteria,434Z5@68525|delta/epsilon subdivisions,2WZ9Z@28221|Deltaproteobacteria,2Z1P2@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Arrestin_N
HKD2_k127_9044290_2	661478.OP10G_3830	4.243e-22	101.0	COG1956@1|root,COG1956@2|Bacteria	2|Bacteria	T	GAF domain-containing protein	yebR	-	1.8.4.14	ko:K08968	ko00270,map00270	-	R02025	RC00639	ko00000,ko00001,ko01000	-	-	-	GAF,GAF_2
HKD2_k127_9044290_1	272562.CA_C2810	7.853e-45	179.0	COG3387@1|root,COG3387@2|Bacteria,1TR12@1239|Firmicutes,248Q3@186801|Clostridia,36Q39@31979|Clostridiaceae	186801|Clostridia	G	Glycosyl hydrolases family 15	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_15
HKD2_k127_9047863_3	48698.ENSPFOP00000030879	4.774e-05	55.0	KOG4297@1|root,KOG4297@2759|Eukaryota,39Z2X@33154|Opisthokonta,3BNS0@33208|Metazoa,3D1AT@33213|Bilateria,48AZT@7711|Chordata	33208|Metazoa	TV	carbohydrate binding	-	-	-	ko:K17513	-	-	-	-	ko00000,ko04091	-	-	-	Lectin_C
HKD2_k127_9047863_0	1254432.SCE1572_02715	2.863e-58	220.0	COG0515@1|root,COG0515@2|Bacteria,1Q38J@1224|Proteobacteria,438ZJ@68525|delta/epsilon subdivisions,2X44T@28221|Deltaproteobacteria,2YY98@29|Myxococcales	28221|Deltaproteobacteria	KLT	Protein kinase domain	masK	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HKD2_k127_9047863_2	404589.Anae109_3774	1.057e-05	58.0	COG0457@1|root,COG0457@2|Bacteria,1PXHP@1224|Proteobacteria,434K6@68525|delta/epsilon subdivisions,2WYXE@28221|Deltaproteobacteria,2Z0V1@29|Myxococcales	28221|Deltaproteobacteria	S	TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	PEGA,TPR_16
HKD2_k127_9047863_1	1192034.CAP_3445	3.339e-58	207.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions	1224|Proteobacteria	T	two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	ko:K07712	ko02020,map02020	M00497	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	FHA,HTH_8,Response_reg,Sigma54_activat,Yop-YscD_cpl
HKD2_k127_9048198_1	330214.NIDE1256	5.254e-68	240.0	COG2204@1|root,COG2204@2|Bacteria,3J10B@40117|Nitrospirae	40117|Nitrospirae	T	Sigma-54 interaction domain	-	-	-	ko:K07714	ko02020,map02020	M00500	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD2_k127_9048198_0	215803.DB30_6131	4.135e-72	254.0	COG1428@1|root,COG1428@2|Bacteria,1RC50@1224|Proteobacteria,42ZS6@68525|delta/epsilon subdivisions,2WUZM@28221|Deltaproteobacteria,2YYRA@29|Myxococcales	28221|Deltaproteobacteria	F	Deoxynucleoside kinase	-	-	-	-	-	-	-	-	-	-	-	-	dNK
HKD2_k127_9048198_2	1379698.RBG1_1C00001G1510	9.206e-53	205.0	COG0312@1|root,COG0312@2|Bacteria,2NP7I@2323|unclassified Bacteria	2|Bacteria	S	Putative modulator of DNA gyrase	tldE2	-	-	ko:K03592	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
HKD2_k127_9048198_3	1283299.AUKG01000002_gene4207	2.461e-15	76.0	COG0312@1|root,COG0312@2|Bacteria,2GJ4E@201174|Actinobacteria,4CS03@84995|Rubrobacteria	84995|Rubrobacteria	S	Putative modulator of DNA gyrase	-	-	-	-	-	-	-	-	-	-	-	-	PmbA_TldD
HKD2_k127_9052381_0	1254432.SCE1572_00180	3.754e-217	692.0	COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,42MJB@68525|delta/epsilon subdivisions,2WIXF@28221|Deltaproteobacteria,2YUHY@29|Myxococcales	28221|Deltaproteobacteria	M	penicillin-binding protein	mrcA	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	iAF987.Gmet_0354	PCB_OB,Transgly,Transpeptidase
HKD2_k127_9052381_4	1242864.D187_000795	9.989e-27	113.0	2DQ44@1|root,334NC@2|Bacteria,1NCSR@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF962
HKD2_k127_9052381_1	1254432.SCE1572_51110	1.496e-115	406.0	COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,42MCN@68525|delta/epsilon subdivisions,2WIYA@28221|Deltaproteobacteria,2YUYF@29|Myxococcales	28221|Deltaproteobacteria	T	Histidine kinase	ntrY	-	2.7.13.3	ko:K13598	ko02020,map02020	M00498	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4
HKD2_k127_9053653_0	1192034.CAP_4568	1.471e-78	278.0	COG0515@1|root,COG0515@2|Bacteria,1Q2R6@1224|Proteobacteria,433VB@68525|delta/epsilon subdivisions,2X3MY@28221|Deltaproteobacteria,2YWK6@29|Myxococcales	28221|Deltaproteobacteria	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HKD2_k127_9053653_1	1192034.CAP_0339	2.466e-69	237.0	COG0553@1|root,COG4715@1|root,COG0553@2|Bacteria,COG4715@2|Bacteria,1MV6M@1224|Proteobacteria,42M5P@68525|delta/epsilon subdivisions,2WIW8@28221|Deltaproteobacteria,2YU7C@29|Myxococcales	28221|Deltaproteobacteria	KL	helicase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Helicase_C,SNF2_N,SNF2_assoc,SWIM
HKD2_k127_9055225_1	591167.Sfla_6009	1.988e-15	81.0	COG2968@1|root,COG2968@2|Bacteria	2|Bacteria	S	cellular response to heat	omp28	GO:0005575,GO:0005623,GO:0042597,GO:0044464	-	ko:K09807	-	-	-	-	ko00000	-	-	-	SIMPL
HKD2_k127_9055225_0	1238184.CM001792_gene2467	1.932e-18	85.0	COG2224@1|root,COG2224@2|Bacteria,1TP1U@1239|Firmicutes,4HBBD@91061|Bacilli,23MRA@182709|Oceanobacillus	91061|Bacilli	C	Phosphoenolpyruvate phosphomutase	aceA	-	4.1.3.1	ko:K01637	ko00630,ko01100,ko01110,ko01120,ko01200,map00630,map01100,map01110,map01120,map01200	M00012	R00479	RC00311,RC00313	ko00000,ko00001,ko00002,ko01000	-	-	-	ICL
HKD2_k127_9066812_4	1192034.CAP_2249	2.922e-62	218.0	COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,42N87@68525|delta/epsilon subdivisions,2WV45@28221|Deltaproteobacteria,2YZDV@29|Myxococcales	28221|Deltaproteobacteria	S	ABC1 family	-	-	-	-	-	-	-	-	-	-	-	-	ABC1
HKD2_k127_9066812_3	396588.Tgr7_2557	1.083e-74	261.0	COG0426@1|root,COG0426@2|Bacteria	2|Bacteria	C	nitric oxide reductase activity	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HKD2_k127_9066812_7	1192034.CAP_5117	3.422e-20	103.0	COG1716@1|root,COG1716@2|Bacteria	2|Bacteria	T	histone H2A K63-linked ubiquitination	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9066812_5	448385.sce4289	1.87e-38	155.0	COG2267@1|root,COG2267@2|Bacteria,1QX85@1224|Proteobacteria,42W1M@68525|delta/epsilon subdivisions,2WR6V@28221|Deltaproteobacteria,2YUZN@29|Myxococcales	28221|Deltaproteobacteria	I	alpha beta	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
HKD2_k127_9066812_2	448385.sce6858	1.527e-82	303.0	COG0457@1|root,COG3903@1|root,COG0457@2|Bacteria,COG3903@2|Bacteria,1MWPD@1224|Proteobacteria,438M3@68525|delta/epsilon subdivisions,2X1ZS@28221|Deltaproteobacteria,2YX8A@29|Myxococcales	28221|Deltaproteobacteria	T	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_22,Guanylate_cyc,TPR_12
HKD2_k127_9066812_0	290397.Adeh_3457	3.063e-182	582.0	COG0554@1|root,COG0554@2|Bacteria,1MUP7@1224|Proteobacteria,42M9Z@68525|delta/epsilon subdivisions,2WIYZ@28221|Deltaproteobacteria,2YU0Z@29|Myxococcales	28221|Deltaproteobacteria	F	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate	glpK	GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615	2.7.1.30	ko:K00864	ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626	-	R00847	RC00002,RC00017	ko00000,ko00001,ko01000,ko04147	-	-	-	FGGY_C,FGGY_N
HKD2_k127_9066812_1	448385.sce7618	9.427e-95	317.0	COG1708@1|root,COG1708@2|Bacteria,1NKZT@1224|Proteobacteria,430VC@68525|delta/epsilon subdivisions,2WVUS@28221|Deltaproteobacteria,2Z164@29|Myxococcales	28221|Deltaproteobacteria	S	Uncharacterised protein family (UPF0158)	-	-	-	-	-	-	-	-	-	-	-	-	UPF0158
HKD2_k127_9066826_7	1268240.ATFI01000001_gene2927	2.286e-68	252.0	COG1541@1|root,COG1541@2|Bacteria,4NFRI@976|Bacteroidetes,2FMJX@200643|Bacteroidia,4AKHJ@815|Bacteroidaceae	976|Bacteroidetes	H	GH3 auxin-responsive promoter	-	-	-	-	-	-	-	-	-	-	-	-	GH3
HKD2_k127_9066826_2	42256.RradSPS_2403	8.594e-114	380.0	COG1260@1|root,COG1260@2|Bacteria,2GJVN@201174|Actinobacteria	201174|Actinobacteria	I	Myo-inositol-1-phosphate synthase	-	-	5.5.1.4	ko:K01858	ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130	-	R07324	RC01804	ko00000,ko00001,ko01000	-	-	-	Inos-1-P_synth,NAD_binding_5
HKD2_k127_9066826_6	591158.SSMG_02501	1.262e-84	296.0	COG0399@1|root,COG0399@2|Bacteria,2GKD7@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the DegT DnrJ EryC1 family	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
HKD2_k127_9066826_11	246197.MXAN_0849	2.044e-22	112.0	COG0392@1|root,COG0392@2|Bacteria,1QDIG@1224|Proteobacteria,434TJ@68525|delta/epsilon subdivisions,2WZ4H@28221|Deltaproteobacteria,2Z1B9@29|Myxococcales	28221|Deltaproteobacteria	S	Lysylphosphatidylglycerol synthase TM region	-	-	-	-	-	-	-	-	-	-	-	-	LPG_synthase_TM
HKD2_k127_9066826_8	448385.sce6547	7.089e-68	252.0	COG0829@1|root,COG0829@2|Bacteria,1NY7J@1224|Proteobacteria,42XVF@68525|delta/epsilon subdivisions,2WNBZ@28221|Deltaproteobacteria,2YUTW@29|Myxococcales	28221|Deltaproteobacteria	J	Required for maturation of urease via the functional incorporation of the urease nickel metallocenter	ureD	-	-	ko:K03190	-	-	-	-	ko00000	-	-	-	UreD
HKD2_k127_9066826_4	215803.DB30_6309	1.412e-93	312.0	COG0831@1|root,COG0832@1|root,COG0831@2|Bacteria,COG0832@2|Bacteria,1RGXE@1224|Proteobacteria,42QQW@68525|delta/epsilon subdivisions,2WPBR@28221|Deltaproteobacteria,2YVJY@29|Myxococcales	28221|Deltaproteobacteria	E	Urease, gamma subunit	ureA	-	3.5.1.5	ko:K01430,ko:K14048	ko00220,ko00230,ko00791,ko01100,ko01120,ko05120,map00220,map00230,map00791,map01100,map01120,map05120	-	R00131	RC02798,RC02806	ko00000,ko00001,ko01000	-	-	-	Urease_beta,Urease_gamma
HKD2_k127_9066826_0	1144275.COCOR_07674	1.881e-308	962.0	COG0804@1|root,COG0804@2|Bacteria,1MU5P@1224|Proteobacteria,42NUG@68525|delta/epsilon subdivisions,2WJM4@28221|Deltaproteobacteria,2YUI0@29|Myxococcales	28221|Deltaproteobacteria	E	Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family	ureC	-	3.5.1.5	ko:K01428	ko00220,ko00230,ko00791,ko01100,ko01120,ko05120,map00220,map00230,map00791,map01100,map01120,map05120	-	R00131	RC02798,RC02806	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1,Urease_alpha
HKD2_k127_9066826_10	448385.sce6550	9.285e-55	212.0	COG0830@1|root,COG0830@2|Bacteria,1NIBD@1224|Proteobacteria,42Y30@68525|delta/epsilon subdivisions,2X0IY@28221|Deltaproteobacteria,2YVZ0@29|Myxococcales	28221|Deltaproteobacteria	O	Required for maturation of urease via the functional incorporation of the urease nickel metallocenter	ureF	-	-	ko:K03188	-	-	-	-	ko00000	-	-	-	UreF
HKD2_k127_9066826_3	483219.LILAB_04640	2.089e-95	329.0	COG0378@1|root,COG0378@2|Bacteria,1MVBD@1224|Proteobacteria,42P7Y@68525|delta/epsilon subdivisions,2WKXK@28221|Deltaproteobacteria,2YUNK@29|Myxococcales	28221|Deltaproteobacteria	KO	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG	ureG	-	-	ko:K03189	-	-	-	-	ko00000	-	-	-	cobW
HKD2_k127_9066826_1	448385.sce8599	2.968e-170	550.0	2A4BQ@1|root,30SXD@2|Bacteria,1PCFN@1224|Proteobacteria,438EV@68525|delta/epsilon subdivisions,2WYPE@28221|Deltaproteobacteria,2YWSY@29|Myxococcales	28221|Deltaproteobacteria	S	IgGFc binding protein	-	-	-	-	-	-	-	-	-	-	-	-	IgGFc_binding
HKD2_k127_9066826_5	290397.Adeh_3668	2.902e-86	299.0	COG0475@1|root,COG0475@2|Bacteria,1RB9F@1224|Proteobacteria,42UIK@68525|delta/epsilon subdivisions,2X5D2@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	Sodium/hydrogen exchanger family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
HKD2_k127_9066826_9	1120956.JHZK01000029_gene51	2.12e-64	231.0	COG0483@1|root,COG0483@2|Bacteria,1MUQT@1224|Proteobacteria,2TR06@28211|Alphaproteobacteria,1JMZ5@119043|Rhodobiaceae	28211|Alphaproteobacteria	G	Inositol monophosphatase family	suhB	-	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
HKD2_k127_9071824_0	1254432.SCE1572_51420	7.763e-105	352.0	COG0324@1|root,COG0324@2|Bacteria,1MUB2@1224|Proteobacteria,42M7V@68525|delta/epsilon subdivisions,2WIUB@28221|Deltaproteobacteria,2YUX2@29|Myxococcales	28221|Deltaproteobacteria	J	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)	miaA	GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016765,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0052381,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.5.1.75	ko:K00791	ko00908,ko01100,ko01110,map00908,map01100,map01110	-	R01122	RC02820	ko00000,ko00001,ko01000,ko01006,ko03016	-	-	-	IPPT
HKD2_k127_9071824_3	1192034.CAP_7792	9.864e-51	195.0	COG0346@1|root,COG0346@2|Bacteria,1RH79@1224|Proteobacteria,43ACF@68525|delta/epsilon subdivisions,2X5SA@28221|Deltaproteobacteria,2Z208@29|Myxococcales	28221|Deltaproteobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HKD2_k127_9071824_5	1206739.BAGJ01000173_gene3687	1.799e-34	151.0	COG0596@1|root,COG0596@2|Bacteria,2IDW0@201174|Actinobacteria,4G0Y2@85025|Nocardiaceae	201174|Actinobacteria	S	alpha/beta hydrolase fold	-	-	3.1.1.24	ko:K01055	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00568	R02991	RC00825	ko00000,ko00001,ko00002,ko01000	-	-	-	Abhydrolase_1,Abhydrolase_4,Abhydrolase_6
HKD2_k127_9071824_1	448385.sce0177	5.86e-62	224.0	COG0583@1|root,COG0583@2|Bacteria,1N663@1224|Proteobacteria,42ZUV@68525|delta/epsilon subdivisions,2WVFG@28221|Deltaproteobacteria,2YV24@29|Myxococcales	28221|Deltaproteobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HKD2_k127_9071824_2	330214.NIDE0009	4.396e-60	218.0	COG0702@1|root,COG0702@2|Bacteria	2|Bacteria	GM	epimerase	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_10,NmrA
HKD2_k127_9071824_7	1192034.CAP_4145	8.255e-17	80.0	COG0760@1|root,COG0760@2|Bacteria	2|Bacteria	O	peptidyl-prolyl cis-trans isomerase activity	nifM	-	5.2.1.8	ko:K01802,ko:K03769,ko:K03770	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_2,Rotamase_3,SurA_N_3
HKD2_k127_9075898_3	1192034.CAP_8851	9.478e-18	86.0	COG2425@1|root,COG2425@2|Bacteria,1Q5ER@1224|Proteobacteria,4341B@68525|delta/epsilon subdivisions,2X4M9@28221|Deltaproteobacteria,2YZ8P@29|Myxococcales	28221|Deltaproteobacteria	S	protein containing a von Willebrand factor type A (vWA) domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9075898_0	349521.HCH_03317	4.421e-196	646.0	COG3831@1|root,COG3831@2|Bacteria	2|Bacteria	-	-	yehI	-	-	-	-	-	-	-	-	-	-	-	DUF4132,WGR
HKD2_k127_9075898_4	448385.sce4450	3.169e-11	69.0	COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,42MMA@68525|delta/epsilon subdivisions,2WIZB@28221|Deltaproteobacteria,2YUN3@29|Myxococcales	28221|Deltaproteobacteria	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamA	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
HKD2_k127_9077723_1	1192034.CAP_2106	1.474e-88	319.0	COG0308@1|root,COG0308@2|Bacteria,1RBHC@1224|Proteobacteria,42QWW@68525|delta/epsilon subdivisions,2WMP2@28221|Deltaproteobacteria,2YUU2@29|Myxococcales	28221|Deltaproteobacteria	E	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_19
HKD2_k127_9077723_0	448385.sce9038	4.814e-185	623.0	COG1196@1|root,COG1196@2|Bacteria,1QX9X@1224|Proteobacteria,43018@68525|delta/epsilon subdivisions,2WVD9@28221|Deltaproteobacteria,2YW2N@29|Myxococcales	28221|Deltaproteobacteria	D	Domain of unknown function (DUF4175)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4175
HKD2_k127_9077723_2	448385.sce2574	5.973e-48	187.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,42NY2@68525|delta/epsilon subdivisions,2WJKQ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	KLT	SMART serine threonine protein kinase	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	DUF1566,Pkinase
HKD2_k127_9093085_1	448385.sce3538	1.584e-56	222.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria	1224|Proteobacteria	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HKD2_k127_9093085_0	1242864.D187_002248	2.757e-126	413.0	COG3831@1|root,COG3831@2|Bacteria,1QWC3@1224|Proteobacteria	1224|Proteobacteria	S	Domain of unknown function (DUF4132)	JD73_20480	-	-	-	-	-	-	-	-	-	-	-	DUF4132,WGR
HKD2_k127_9102127_1	937777.Deipe_0154	8.044e-83	280.0	COG2225@1|root,COG2225@2|Bacteria,1WIVZ@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	Belongs to the malate synthase family	-	-	2.3.3.9	ko:K01638	ko00620,ko00630,ko01100,ko01110,ko01120,ko01200,map00620,map00630,map01100,map01110,map01120,map01200	M00012	R00472	RC00004,RC00308,RC02747	ko00000,ko00001,ko00002,ko01000	-	-	-	Malate_synthase
HKD2_k127_9102127_0	502025.Hoch_6436	1.14e-154	501.0	COG1396@1|root,COG3800@1|root,COG1396@2|Bacteria,COG3800@2|Bacteria,1MU50@1224|Proteobacteria,43B2B@68525|delta/epsilon subdivisions,2X6GC@28221|Deltaproteobacteria,2Z3AZ@29|Myxococcales	28221|Deltaproteobacteria	K	Pfam:DUF955	-	-	-	ko:K07110	-	-	-	-	ko00000,ko03000	-	-	-	DUF2083,HTH_3,HTH_31,Peptidase_M78
HKD2_k127_9109964_10	1192034.CAP_2400	5.799e-27	121.0	COG3221@1|root,COG3221@2|Bacteria,1MXD8@1224|Proteobacteria,42VZ4@68525|delta/epsilon subdivisions,2WRDI@28221|Deltaproteobacteria,2YW4T@29|Myxococcales	28221|Deltaproteobacteria	P	ABC transporter, phosphonate, periplasmic substrate-binding protein	phnD	-	-	ko:K02044	ko02010,map02010	M00223	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.9	-	-	Phosphonate-bd
HKD2_k127_9109964_2	1242864.D187_004066	4.808e-80	287.0	COG0583@1|root,COG0583@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HKD2_k127_9109964_3	387093.SUN_0830	5.101e-70	259.0	COG3034@1|root,COG3034@2|Bacteria,1MXY6@1224|Proteobacteria,42RRD@68525|delta/epsilon subdivisions	1224|Proteobacteria	S	L,D-transpeptidase catalytic domain	yafK	-	-	-	-	-	-	-	-	-	-	-	YkuD
HKD2_k127_9109964_12	929713.NIASO_11710	4.33e-10	72.0	2C0B6@1|root,32R6Q@2|Bacteria,4NQ51@976|Bacteroidetes,1IWS2@117747|Sphingobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9109964_6	1134474.O59_000004	1.19e-43	176.0	COG3757@1|root,COG3757@2|Bacteria,1N792@1224|Proteobacteria,1S6KA@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	glycoside hydrolase, family	-	-	-	ko:K07273	-	-	-	-	ko00000	-	-	-	Glyco_hydro_25
HKD2_k127_9109964_4	1254432.SCE1572_27305	6.712e-60	228.0	COG3215@1|root,COG3215@2|Bacteria,1QR4G@1224|Proteobacteria,4352F@68525|delta/epsilon subdivisions,2WZDD@28221|Deltaproteobacteria,2Z1W5@29|Myxococcales	28221|Deltaproteobacteria	NU	PilZ domain	-	-	-	-	-	-	-	-	-	-	-	-	PilZ
HKD2_k127_9109964_9	1278073.MYSTI_05722	1.709e-32	147.0	COG1846@1|root,COG1846@2|Bacteria,1RKAV@1224|Proteobacteria,42VFQ@68525|delta/epsilon subdivisions,2WRWP@28221|Deltaproteobacteria,2YV9F@29|Myxococcales	28221|Deltaproteobacteria	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	MarR
HKD2_k127_9109964_7	234267.Acid_7028	1.176e-35	157.0	COG0154@1|root,COG0154@2|Bacteria	2|Bacteria	J	amidase activity	gatA3	-	3.5.1.4,6.3.5.6,6.3.5.7	ko:K01426,ko:K02433	ko00330,ko00360,ko00380,ko00627,ko00643,ko00970,ko01100,ko01120,map00330,map00360,map00380,map00627,map00643,map00970,map01100,map01120	-	R02540,R03096,R03180,R03905,R03909,R04212,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
HKD2_k127_9109964_0	1242864.D187_005800	2.229e-179	573.0	COG1899@1|root,COG1899@2|Bacteria,1MVC6@1224|Proteobacteria	1224|Proteobacteria	O	Belongs to the deoxyhypusine synthase family	-	-	2.5.1.46	ko:K00809	-	-	-	-	ko00000,ko01000	-	-	-	DS
HKD2_k127_9109964_5	290397.Adeh_1215	1.172e-47	181.0	COG2912@1|root,COG2912@2|Bacteria,1MVJQ@1224|Proteobacteria,43824@68525|delta/epsilon subdivisions,2X3C7@28221|Deltaproteobacteria,2YVD2@29|Myxococcales	28221|Deltaproteobacteria	S	Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	TPR_9,Transglut_core2
HKD2_k127_9109964_1	1192034.CAP_4343	4.987e-87	310.0	COG0515@1|root,COG0515@2|Bacteria	1192034.CAP_4343|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9111786_2	1254432.SCE1572_37335	7.242e-55	201.0	COG0354@1|root,COG0354@2|Bacteria,1QYGE@1224|Proteobacteria,43CCJ@68525|delta/epsilon subdivisions,2WYDB@28221|Deltaproteobacteria,2Z3H2@29|Myxococcales	28221|Deltaproteobacteria	H	Belongs to the GcvT family	ygfZ	-	-	ko:K06980	-	-	-	-	ko00000,ko03016	-	-	-	GCV_T,GCV_T_C
HKD2_k127_9111786_5	1472716.KBK24_0104205	8.609e-20	94.0	2EFEY@1|root,3397R@2|Bacteria,1N9ZY@1224|Proteobacteria,2W2BA@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9111786_4	448385.sce5936	2.73e-26	124.0	COG1661@1|root,COG1661@2|Bacteria	2|Bacteria	O	DNA-binding protein with PD1-like DNA-binding motif	-	-	-	ko:K06934	-	-	-	-	ko00000	-	-	-	DUF296
HKD2_k127_9111786_1	448385.sce5935	3.25e-62	235.0	COG2885@1|root,COG2885@2|Bacteria	2|Bacteria	M	chlorophyll binding	-	-	-	ko:K16191,ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001,ko02000	1.B.6.1.3	-	-	BON,Gram_pos_anchor,OmpA,TSP_3
HKD2_k127_9111786_3	1192034.CAP_0030	3.619e-41	159.0	COG0424@1|root,COG0424@2|Bacteria,1RH6H@1224|Proteobacteria,42SR7@68525|delta/epsilon subdivisions,2WP65@28221|Deltaproteobacteria,2YVJK@29|Myxococcales	28221|Deltaproteobacteria	D	Maf-like protein	maf	-	-	ko:K06287	-	-	-	-	ko00000	-	-	-	Maf
HKD2_k127_9111786_0	1192034.CAP_0031	9.243e-105	362.0	COG1807@1|root,COG1807@2|Bacteria,1R092@1224|Proteobacteria,43CRV@68525|delta/epsilon subdivisions,2X7ZG@28221|Deltaproteobacteria,2Z3K8@29|Myxococcales	28221|Deltaproteobacteria	M	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HKD2_k127_9111786_7	759362.KVU_1965	3.716e-15	78.0	2ENFV@1|root,33G39@2|Bacteria,1NP5K@1224|Proteobacteria,2UJUH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9111786_6	1192034.CAP_2499	9.463e-20	88.0	COG0316@1|root,COG0316@2|Bacteria,1RHCW@1224|Proteobacteria,431E6@68525|delta/epsilon subdivisions,2WWGA@28221|Deltaproteobacteria,2YVXB@29|Myxococcales	28221|Deltaproteobacteria	S	Belongs to the HesB IscA family	-	-	-	ko:K13628	-	-	-	-	ko00000,ko03016	-	-	-	Fe-S_biosyn
HKD2_k127_9118283_1	1118054.CAGW01000075_gene3268	1.276e-34	140.0	COG0500@1|root,COG0500@2|Bacteria,1V862@1239|Firmicutes,4HTY9@91061|Bacilli,26WVH@186822|Paenibacillaceae	91061|Bacilli	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9118283_3	246197.MXAN_0279	1.113e-06	59.0	COG0858@1|root,COG0858@2|Bacteria	2|Bacteria	J	rRNA processing	rbfA	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009266,GO:0009409,GO:0009628,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0030490,GO:0033554,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042274,GO:0043021,GO:0043024,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071840,GO:0090304,GO:1901360	-	ko:K02834	-	-	-	-	ko00000,ko03009	-	-	-	RBFA
HKD2_k127_9118283_0	215803.DB30_5486	8.506e-86	289.0	COG2085@1|root,COG2085@2|Bacteria,1NF95@1224|Proteobacteria,4380B@68525|delta/epsilon subdivisions,2X3AC@28221|Deltaproteobacteria,2YURK@29|Myxococcales	28221|Deltaproteobacteria	S	NADP oxidoreductase coenzyme F420-dependent	-	-	1.5.1.40	ko:K06988	-	-	-	-	ko00000,ko01000	-	-	-	F420_oxidored
HKD2_k127_9118283_2	1121943.KB899989_gene3410	9.634e-07	57.0	COG0046@1|root,COG0047@1|root,COG0046@2|Bacteria,COG0047@2|Bacteria,1MYN4@1224|Proteobacteria,1RMRN@1236|Gammaproteobacteria,1XH4B@135619|Oceanospirillales	135619|Oceanospirillales	F	Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS_C,GATase_5
HKD2_k127_9119957_4	1217720.ALOX01000008_gene1745	1.607e-26	121.0	COG0566@1|root,COG0566@2|Bacteria,1MXGV@1224|Proteobacteria,2U6F8@28211|Alphaproteobacteria,2JRX3@204441|Rhodospirillales	204441|Rhodospirillales	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family	-	-	-	ko:K03214	-	-	-	-	ko00000,ko01000,ko03009,ko03016	-	-	-	SpoU_methylase,SpoU_sub_bind
HKD2_k127_9119957_2	404589.Anae109_2147	1.804e-50	192.0	COG2128@1|root,COG2128@2|Bacteria,1RDRU@1224|Proteobacteria,4311A@68525|delta/epsilon subdivisions,2WWGN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity	ahpD	-	-	ko:K04756	-	-	-	-	ko00000	-	-	-	CMD
HKD2_k127_9119957_1	290397.Adeh_0313	5.587e-82	277.0	COG0450@1|root,COG0450@2|Bacteria,1MWPY@1224|Proteobacteria,42MAJ@68525|delta/epsilon subdivisions,2WP90@28221|Deltaproteobacteria,2YVP3@29|Myxococcales	28221|Deltaproteobacteria	O	Alkyl hydroperoxide reductase	prx-1	-	1.11.1.15	ko:K03386	ko04214,map04214	-	-	-	ko00000,ko00001,ko01000,ko04147	-	-	-	1-cysPrx_C,AhpC-TSA
HKD2_k127_9119957_0	1242864.D187_006558	1.973e-112	370.0	COG0583@1|root,COG0583@2|Bacteria,1MVA1@1224|Proteobacteria,42VVS@68525|delta/epsilon subdivisions,2X5WR@28221|Deltaproteobacteria,2YVAQ@29|Myxococcales	28221|Deltaproteobacteria	K	Bacterial regulatory helix-turn-helix protein, lysR family	-	-	-	ko:K04761	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_1,LysR_substrate
HKD2_k127_9119957_5	448385.sce8541	7.57e-10	68.0	COG3509@1|root,COG3509@2|Bacteria,1PI9N@1224|Proteobacteria,439C2@68525|delta/epsilon subdivisions,2X4K6@28221|Deltaproteobacteria,2YVGR@29|Myxococcales	28221|Deltaproteobacteria	Q	Carbohydrate family 9 binding domain-like	-	-	-	-	-	-	-	-	-	-	-	-	CBM9_1
HKD2_k127_9119957_3	1232410.KI421413_gene715	4.996e-45	175.0	COG1940@1|root,COG1940@2|Bacteria,1MU94@1224|Proteobacteria,42RF4@68525|delta/epsilon subdivisions,2WPIV@28221|Deltaproteobacteria,43TWB@69541|Desulfuromonadales	28221|Deltaproteobacteria	GK	PFAM ROK family protein	glkA	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
HKD2_k127_9120844_1	1192034.CAP_2009	4.063e-19	91.0	COG3292@1|root,COG3292@2|Bacteria,1Q3P3@1224|Proteobacteria,439GA@68525|delta/epsilon subdivisions,2X4S8@28221|Deltaproteobacteria,2YZHD@29|Myxococcales	28221|Deltaproteobacteria	T	Two component regulator propeller	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9120844_0	1254432.SCE1572_43840	1.515e-160	526.0	COG3064@1|root,COG3064@2|Bacteria	2|Bacteria	M	translation initiation factor activity	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S55
HKD2_k127_9121429_0	448385.sce5115	8.54e-312	973.0	COG0550@1|root,COG0551@1|root,COG0550@2|Bacteria,COG0551@2|Bacteria,1MUFZ@1224|Proteobacteria,42MM9@68525|delta/epsilon subdivisions,2WJTT@28221|Deltaproteobacteria,2YU14@29|Myxococcales	28221|Deltaproteobacteria	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,zf-C4_Topoisom
HKD2_k127_9121429_4	671143.DAMO_2141	1.079e-47	179.0	COG4122@1|root,COG4122@2|Bacteria,2NPV6@2323|unclassified Bacteria	2|Bacteria	S	Methyltransferase domain	yrrM	-	2.1.1.104	ko:K00588	ko00360,ko00940,ko00941,ko00945,ko01100,ko01110,map00360,map00940,map00941,map00945,map01100,map01110	M00039,M00350	R01942,R06578	RC00003,RC00392	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_3
HKD2_k127_9121429_2	1254432.SCE1572_21655	2.669e-57	207.0	COG0782@1|root,COG0782@2|Bacteria,1RAP0@1224|Proteobacteria,42UCT@68525|delta/epsilon subdivisions,2WPAW@28221|Deltaproteobacteria,2YV7B@29|Myxococcales	28221|Deltaproteobacteria	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus	greB	-	-	ko:K04760	-	-	-	-	ko00000,ko03021	-	-	-	GreA_GreB,GreA_GreB_N
HKD2_k127_9121429_10	404589.Anae109_2744	1.043e-09	67.0	2AJ10@1|root,319J4@2|Bacteria,1Q2X4@1224|Proteobacteria,438K5@68525|delta/epsilon subdivisions,2X3UQ@28221|Deltaproteobacteria,2YX5Z@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9121429_3	448385.sce6727	1.839e-49	193.0	COG4409@1|root,COG4409@2|Bacteria	2|Bacteria	G	exo-alpha-(2->6)-sialidase activity	nanA	GO:0001573,GO:0003674,GO:0003824,GO:0004308,GO:0004553,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006629,GO:0006643,GO:0006664,GO:0006665,GO:0006672,GO:0006687,GO:0006689,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009311,GO:0009313,GO:0009987,GO:0016020,GO:0016042,GO:0016052,GO:0016787,GO:0016798,GO:0016997,GO:0019377,GO:0030149,GO:0034641,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043603,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044424,GO:0044464,GO:0046466,GO:0046479,GO:0046514,GO:0071704,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575,GO:1903509	3.2.1.18	ko:K01186	ko00511,ko00600,ko04142,map00511,map00600,map04142	-	R04018	RC00028,RC00077	ko00000,ko00001,ko01000,ko02042	-	GH33	-	BNR_2,Gram_pos_anchor,Sialidase,YSIRK_signal
HKD2_k127_9121429_5	448385.sce5056	1.703e-44	177.0	COG3391@1|root,COG3391@2|Bacteria,1Q2FG@1224|Proteobacteria,4381D@68525|delta/epsilon subdivisions,2X3BF@28221|Deltaproteobacteria,2YV8V@29|Myxococcales	28221|Deltaproteobacteria	S	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9121429_1	1254432.SCE1572_40325	4.048e-60	235.0	COG0457@1|root,COG3903@1|root,COG0457@2|Bacteria,COG3903@2|Bacteria,1MWPD@1224|Proteobacteria,438M3@68525|delta/epsilon subdivisions,2X1ZS@28221|Deltaproteobacteria,2YX8A@29|Myxococcales	28221|Deltaproteobacteria	T	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_22,Guanylate_cyc,TPR_12
HKD2_k127_9121429_6	448385.sce9090	3.161e-44	172.0	COG1262@1|root,COG1262@2|Bacteria	2|Bacteria	T	PFAM Formylglycine-generating sulfatase enzyme	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase,HdeA
HKD2_k127_9121429_8	448385.sce9090	1.646e-27	126.0	COG1262@1|root,COG1262@2|Bacteria	2|Bacteria	T	PFAM Formylglycine-generating sulfatase enzyme	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase,HdeA
HKD2_k127_9121558_2	1056816.JAFQ01000004_gene136	1.747e-62	217.0	COG0535@1|root,COG0535@2|Bacteria,2HHA8@201174|Actinobacteria,4FWFI@85025|Nocardiaceae	201174|Actinobacteria	S	Domain of unknown function (DUF3463)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3463,Fer4_14,Radical_SAM
HKD2_k127_9121558_5	675635.Psed_3681	1.715e-26	128.0	COG0761@1|root,COG0775@1|root,COG0761@2|Bacteria,COG0775@2|Bacteria,2GIZ7@201174|Actinobacteria,4DZDW@85010|Pseudonocardiales	201174|Actinobacteria	IM	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis	ispH	-	1.17.7.4	ko:K03527	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05884,R08210	RC01137,RC01487	ko00000,ko00001,ko00002,ko01000	-	-	-	LYTB,PNP_UDP_1
HKD2_k127_9121558_0	2002.JOEQ01000031_gene1587	5.033e-259	837.0	COG1657@1|root,COG1657@2|Bacteria,2GM7H@201174|Actinobacteria,4EFV5@85012|Streptosporangiales	201174|Actinobacteria	I	Squalene-hopene cyclase N-terminal domain	shc	-	4.2.1.129,5.4.99.17	ko:K06045	ko00909,ko01110,map00909,map01110	-	R07322,R07323	RC01850,RC01851	ko00000,ko00001,ko01000	-	-	-	SQHop_cyclase_C,SQHop_cyclase_N
HKD2_k127_9121558_4	1110502.TMO_1287	5.03e-30	135.0	COG4221@1|root,COG4221@2|Bacteria,1MUF8@1224|Proteobacteria,2TUSA@28211|Alphaproteobacteria,2JS0N@204441|Rhodospirillales	204441|Rhodospirillales	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HKD2_k127_9121558_1	886293.Sinac_6047	2.808e-74	255.0	2C03A@1|root,2Z86B@2|Bacteria,2IXDZ@203682|Planctomycetes	203682|Planctomycetes	S	Domain of unknown function (DUF4291)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4291
HKD2_k127_9121558_3	1254432.SCE1572_10370	2.291e-41	154.0	COG1186@1|root,COG1186@2|Bacteria,1MUAW@1224|Proteobacteria,42MKD@68525|delta/epsilon subdivisions,2WIZP@28221|Deltaproteobacteria,2YU17@29|Myxococcales	28221|Deltaproteobacteria	J	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA	prfB	-	-	ko:K02836	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
HKD2_k127_9127532_1	483219.LILAB_23790	1.282e-80	290.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,42Q67@68525|delta/epsilon subdivisions,2WKZ1@28221|Deltaproteobacteria,2YUQ6@29|Myxococcales	28221|Deltaproteobacteria	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	AAA_16,Pkinase,TPR_12,zinc_ribbon_2
HKD2_k127_9127532_2	448385.sce6926	6.588e-38	165.0	2E2XW@1|root,32XYS@2|Bacteria,1N3ID@1224|Proteobacteria,42UFM@68525|delta/epsilon subdivisions,2WQKF@28221|Deltaproteobacteria,2YVPU@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9127532_0	1192034.CAP_7364	4.458e-178	573.0	COG0750@1|root,COG0750@2|Bacteria,1MU91@1224|Proteobacteria,42NJ0@68525|delta/epsilon subdivisions,2WJ7A@28221|Deltaproteobacteria,2YTYT@29|Myxococcales	28221|Deltaproteobacteria	M	Peptidase family M50	rseP	-	-	ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_M50
HKD2_k127_9127532_3	573370.DMR_00320	8.676e-19	102.0	COG0144@1|root,COG0781@1|root,COG0144@2|Bacteria,COG0781@2|Bacteria,1MWPE@1224|Proteobacteria,42P2T@68525|delta/epsilon subdivisions,2WJ9B@28221|Deltaproteobacteria,2M9R0@213115|Desulfovibrionales	28221|Deltaproteobacteria	JK	Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family	rsmB	-	2.1.1.176	ko:K03500	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltr_RsmB-F,Methyltr_RsmF_N,NusB
HKD2_k127_9137183_1	448385.sce7634	5.47e-117	396.0	COG3266@1|root,COG3266@2|Bacteria,1PBVF@1224|Proteobacteria,4384T@68525|delta/epsilon subdivisions,2X3EV@28221|Deltaproteobacteria,2YVRI@29|Myxococcales	28221|Deltaproteobacteria	S	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	dCache_3
HKD2_k127_9137183_2	448385.sce7635	3.453e-84	315.0	COG2067@1|root,COG2067@2|Bacteria	2|Bacteria	I	long-chain fatty acid transporting porin activity	-	-	-	ko:K06076	-	-	-	-	ko00000,ko02000	1.B.9	-	-	Toluene_X
HKD2_k127_9137183_0	1192034.CAP_7414	6.595e-133	430.0	COG0492@1|root,COG0492@2|Bacteria,1MV15@1224|Proteobacteria,42MHR@68525|delta/epsilon subdivisions,2WIY8@28221|Deltaproteobacteria,2YUI6@29|Myxococcales	28221|Deltaproteobacteria	C	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family	trxB	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Thioredoxin
HKD2_k127_9137183_3	448385.sce4318	2.176e-07	59.0	COG0664@1|root,COG0664@2|Bacteria,1NBX3@1224|Proteobacteria,42UGQ@68525|delta/epsilon subdivisions,2WQY8@28221|Deltaproteobacteria,2YVI9@29|Myxococcales	28221|Deltaproteobacteria	T	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
HKD2_k127_9143511_5	926550.CLDAP_24600	8.448e-12	66.0	COG0664@1|root,COG0664@2|Bacteria,2G63K@200795|Chloroflexi	200795|Chloroflexi	T	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9143511_6	1134912.AJTV01000010_gene653	5.008e-10	70.0	COG2374@1|root,COG2374@2|Bacteria,1R7ZN@1224|Proteobacteria,2U15A@28211|Alphaproteobacteria,36Z98@31993|Methylocystaceae	28211|Alphaproteobacteria	S	Endonuclease/Exonuclease/phosphatase family	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
HKD2_k127_9143511_1	1254432.SCE1572_27250	9.757e-92	327.0	COG0457@1|root,COG0457@2|Bacteria	1254432.SCE1572_27250|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9143511_3	1121370.AQUY01000004_gene1383	9.916e-42	167.0	COG0515@1|root,COG0515@2|Bacteria,2GJ1J@201174|Actinobacteria,22JIY@1653|Corynebacteriaceae	201174|Actinobacteria	KLT	serine threonine protein kinase	pknB	GO:0000270,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0006022,GO:0006023,GO:0006024,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008047,GO:0008150,GO:0008152,GO:0008360,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009605,GO:0009607,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0010698,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0022603,GO:0022604,GO:0030145,GO:0030203,GO:0030234,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032091,GO:0034645,GO:0036211,GO:0040007,GO:0042304,GO:0042546,GO:0042802,GO:0043085,GO:0043086,GO:0043167,GO:0043169,GO:0043170,GO:0043207,GO:0043388,GO:0043393,GO:0043412,GO:0044036,GO:0044038,GO:0044085,GO:0044092,GO:0044093,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044403,GO:0044419,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046777,GO:0046872,GO:0046890,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0050896,GO:0051055,GO:0051098,GO:0051099,GO:0051100,GO:0051101,GO:0051128,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0062012,GO:0062014,GO:0065007,GO:0065008,GO:0065009,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0075136,GO:0080090,GO:0098772,GO:0140096,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
HKD2_k127_9143511_0	448385.sce7995	6.514e-93	316.0	COG0240@1|root,COG0240@2|Bacteria,1MUU3@1224|Proteobacteria,42NQB@68525|delta/epsilon subdivisions,2WIWW@28221|Deltaproteobacteria,2Z0IC@29|Myxococcales	28221|Deltaproteobacteria	I	Glycerol-3-phosphate dehydrogenase	gpsA	-	1.1.1.94	ko:K00057	ko00564,ko01110,map00564,map01110	-	R00842,R00844	RC00029	ko00000,ko00001,ko01000	-	-	-	NAD_Gly3P_dh_C,NAD_Gly3P_dh_N
HKD2_k127_9143511_2	1254432.SCE1572_18165	4.064e-75	271.0	COG1538@1|root,COG1538@2|Bacteria,1MWX5@1224|Proteobacteria,42SGU@68525|delta/epsilon subdivisions,2WPBP@28221|Deltaproteobacteria,2YVU1@29|Myxococcales	28221|Deltaproteobacteria	MU	Outer membrane efflux protein	-	-	-	ko:K12340	ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133	M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko02044	1.B.17,2.A.6.2	-	-	OEP
HKD2_k127_9143511_7	476272.RUMHYD_03140	1.062e-07	55.0	COG0254@1|root,COG0254@2|Bacteria,1VEGU@1239|Firmicutes,24QNZ@186801|Clostridia,3Y0G4@572511|Blautia	186801|Clostridia	J	Binds the 23S rRNA	rpmE	-	-	ko:K02909	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L31
HKD2_k127_9147701_1	706587.Desti_0626	1.247e-75	256.0	COG2407@1|root,COG2407@2|Bacteria,1NTJI@1224|Proteobacteria	1224|Proteobacteria	G	Converts the aldose L-fucose into the corresponding ketose L-fuculose	-	-	-	-	-	-	-	-	-	-	-	-	Fucose_iso_C
HKD2_k127_9147701_0	448385.sce4286	8.292e-76	266.0	COG1253@1|root,COG1253@2|Bacteria,1MV3P@1224|Proteobacteria,42QX1@68525|delta/epsilon subdivisions,2WMNH@28221|Deltaproteobacteria,2Z2XP@29|Myxococcales	28221|Deltaproteobacteria	S	Transporter associated domain	corC	-	-	ko:K06189	-	-	-	-	ko00000,ko02000	9.A.40.1.2	-	-	CBS,CorC_HlyC,DUF21
HKD2_k127_9155817_0	378806.STAUR_2758	6.22e-38	161.0	COG0265@1|root,COG1266@1|root,COG0265@2|Bacteria,COG1266@2|Bacteria,1NMQX@1224|Proteobacteria,4334M@68525|delta/epsilon subdivisions,2WY91@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	CAAX amino terminal protease family	-	-	-	-	-	-	-	-	-	-	-	-	Abi,PDZ_2
HKD2_k127_9155817_1	448385.sce1846	4.687e-16	80.0	COG0515@1|root,COG3899@1|root,COG0515@2|Bacteria,COG3899@2|Bacteria,1QA6R@1224|Proteobacteria,438FC@68525|delta/epsilon subdivisions,2X3QC@28221|Deltaproteobacteria,2YWU9@29|Myxococcales	28221|Deltaproteobacteria	KLT	Family membership	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,Pkinase,TPR_12
HKD2_k127_9156888_0	1403819.BATR01000094_gene3011	7.377e-125	414.0	COG5557@1|root,COG5557@2|Bacteria,46U15@74201|Verrucomicrobia,2ITS8@203494|Verrucomicrobiae	203494|Verrucomicrobiae	C	Polysulphide reductase, NrfD	-	-	-	-	-	-	-	-	-	-	-	-	NrfD
HKD2_k127_9156888_1	404589.Anae109_2407	8.866e-111	366.0	COG0437@1|root,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,43AKQ@68525|delta/epsilon subdivisions,2X60P@28221|Deltaproteobacteria,2YWQF@29|Myxococcales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	-	-	-	ko:K00184	-	-	-	-	ko00000	5.A.3	-	-	Fer4_11,Fer4_4
HKD2_k127_9156888_4	1121920.AUAU01000009_gene1858	3.988e-32	139.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Paired_CXXCH_1
HKD2_k127_9156888_5	1379698.RBG1_1C00001G0781	1.109e-25	113.0	COG0723@1|root,COG0723@2|Bacteria,2NQ46@2323|unclassified Bacteria	2|Bacteria	C	Rieske [2Fe-2S] domain	petA	-	1.10.2.2,1.10.9.1	ko:K00411,ko:K02636,ko:K03886	ko00190,ko00195,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map00195,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152,M00162	R03817,R08409	RC01002	ko00000,ko00001,ko00002,ko00194,ko01000	-	-	iAF987.Gmet_1922	CytB6-F_Fe-S,Rieske,UCR_Fe-S_N
HKD2_k127_9156888_3	1379698.RBG1_1C00001G0780	5.556e-59	223.0	COG1290@1|root,COG1290@2|Bacteria,2NP8C@2323|unclassified Bacteria	2|Bacteria	C	Cytochrome b(N-terminal)/b6/petB	petB	-	-	ko:K00410,ko:K00412,ko:K02635,ko:K02637	ko00190,ko00195,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map00195,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152,M00162	-	-	ko00000,ko00001,ko00002,ko00194,ko03029	-	-	-	Cytochrom_B_C,Cytochrom_C1,Cytochrome_B
HKD2_k127_9156888_2	1379698.RBG1_1C00001G0779	1.992e-68	252.0	COG2864@1|root,COG2864@2|Bacteria,2NQBN@2323|unclassified Bacteria	2|Bacteria	C	Cytochrome c554 and c-prime	-	-	-	ko:K03620	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	Cytochrom_c3_2,Cytochrome_C554,Ni_hydr_CYTB
HKD2_k127_9156888_6	404589.Anae109_1836	8.68e-13	80.0	COG3005@1|root,COG3005@2|Bacteria,1QYGG@1224|Proteobacteria,42NFU@68525|delta/epsilon subdivisions,2WKHN@28221|Deltaproteobacteria,2Z2AP@29|Myxococcales	28221|Deltaproteobacteria	C	Class III cytochrome C family	-	-	-	-	-	-	-	-	-	-	-	-	Paired_CXXCH_1
HKD2_k127_9159148_5	448385.sce1997	5.991e-21	92.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,42MK5@68525|delta/epsilon subdivisions,2WJ3Z@28221|Deltaproteobacteria,2YZPZ@29|Myxococcales	28221|Deltaproteobacteria	C	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HKD2_k127_9159148_2	1380394.JADL01000017_gene521	3.449e-146	480.0	COG1902@1|root,COG1902@2|Bacteria,1R4A8@1224|Proteobacteria,2UQVT@28211|Alphaproteobacteria,2JW8F@204441|Rhodospirillales	204441|Rhodospirillales	C	COG1902 NADH flavin oxidoreductases, Old Yellow Enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_FMN
HKD2_k127_9159148_7	1254432.SCE1572_23635	1.998e-07	56.0	2E6J8@1|root,3316B@2|Bacteria,1N7GY@1224|Proteobacteria,42V6W@68525|delta/epsilon subdivisions,2WRHG@28221|Deltaproteobacteria,2YYZA@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9159148_4	1278073.MYSTI_01752	1.407e-70	250.0	COG2378@1|root,COG2378@2|Bacteria,1Q3JM@1224|Proteobacteria,439CG@68525|delta/epsilon subdivisions,2X4KT@28221|Deltaproteobacteria,2YZ7T@29|Myxococcales	28221|Deltaproteobacteria	K	HTH domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_11,WYL
HKD2_k127_9159148_0	1254432.SCE1572_12170	2.118e-221	698.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,42MCF@68525|delta/epsilon subdivisions,2WJRK@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	PFAM AMP-dependent synthetase and ligase	bamY	-	6.2.1.25	ko:K04110	ko00362,ko00627,ko01100,ko01120,map00362,map00627,map01100,map01120	-	R01422	RC00004,RC00174	ko00000,ko00001,ko01000	-	-	iAF987.Gmet_2143	AMP-binding,AMP-binding_C
HKD2_k127_9159148_3	1192034.CAP_0949	2.186e-76	281.0	COG1402@1|root,COG1402@2|Bacteria,1MXR9@1224|Proteobacteria,42QNA@68525|delta/epsilon subdivisions,2WIN0@28221|Deltaproteobacteria,2Z10D@29|Myxococcales	28221|Deltaproteobacteria	S	Creatinine amidohydrolase	-	-	3.5.2.10	ko:K01470	ko00330,map00330	-	R01884	RC00615	ko00000,ko00001,ko01000	-	-	-	Creatininase
HKD2_k127_9159148_1	1254432.SCE1572_45955	2.944e-194	635.0	COG2937@1|root,COG2937@2|Bacteria,1MWZ6@1224|Proteobacteria,42MN4@68525|delta/epsilon subdivisions,2WJJ5@28221|Deltaproteobacteria,2YW2Y@29|Myxococcales	28221|Deltaproteobacteria	I	Belongs to the GPAT DAPAT family	-	-	2.3.1.15	ko:K00631	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
HKD2_k127_9159148_6	864051.BurJ1DRAFT_1631	5.188e-12	79.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,2VKJ8@28216|Betaproteobacteria,1KJ47@119065|unclassified Burkholderiales	28216|Betaproteobacteria	KLT	PFAM Protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HKD2_k127_916416_0	448385.sce3602	1.768e-124	423.0	COG3291@1|root,COG3291@2|Bacteria	2|Bacteria	S	metallopeptidase activity	-	-	3.1.3.5,3.2.1.14	ko:K01081,ko:K01183,ko:K20276	ko00230,ko00240,ko00520,ko00760,ko01100,ko01110,ko02024,map00230,map00240,map00520,map00760,map01100,map01110,map02024	-	R00183,R00511,R00963,R01126,R01206,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02334,R02719,R03346	RC00017,RC00467	ko00000,ko00001,ko01000	-	GH18	-	F5_F8_type_C,Melibiase_2,NPCBM_assoc,PKD,PPC,Trypsin_2,VPEP
HKD2_k127_9166124_1	502025.Hoch_4700	4.853e-21	98.0	COG3809@1|root,COG3809@2|Bacteria,1QJZM@1224|Proteobacteria,43E52@68525|delta/epsilon subdivisions,2X98E@28221|Deltaproteobacteria,2Z2KB@29|Myxococcales	28221|Deltaproteobacteria	S	Transcription factor zinc-finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-TFIIB
HKD2_k127_9166124_0	911045.PSE_4580	4.06e-26	109.0	2E9H4@1|root,333Q5@2|Bacteria,1N6SM@1224|Proteobacteria,2UGQ0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9166124_2	1121127.JAFA01000052_gene379	7.177e-15	83.0	COG3741@1|root,COG3741@2|Bacteria,1NBYI@1224|Proteobacteria,2WCBK@28216|Betaproteobacteria,1KDD5@119060|Burkholderiaceae	28216|Betaproteobacteria	E	N-formylglutamate amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9166124_3	485913.Krac_4700	1.364e-09	70.0	2DRZ7@1|root,33DSV@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9166363_2	448385.sce2925	2.655e-53	201.0	2AGXG@1|root,31760@2|Bacteria,1PYEX@1224|Proteobacteria,43E45@68525|delta/epsilon subdivisions,2WZNK@28221|Deltaproteobacteria,2Z2FD@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9166363_0	1254432.SCE1572_27365	4.919e-87	301.0	COG0290@1|root,COG0290@2|Bacteria,1RDD2@1224|Proteobacteria,42RHA@68525|delta/epsilon subdivisions,2WNQW@28221|Deltaproteobacteria,2YVAJ@29|Myxococcales	28221|Deltaproteobacteria	J	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins	infC	GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0006996,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022411,GO:0032790,GO:0032984,GO:0032988,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008	-	ko:K02520	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	IF3_C,IF3_N
HKD2_k127_9174948_6	215803.DB30_4600	1.81e-78	273.0	COG1612@1|root,COG1612@2|Bacteria,1PV6F@1224|Proteobacteria,4303Y@68525|delta/epsilon subdivisions,2WVAK@28221|Deltaproteobacteria,2YUJ2@29|Myxococcales	28221|Deltaproteobacteria	O	cytochrome oxidase assembly	ctaA	-	-	ko:K02259	ko00190,ko00860,ko01100,ko01110,ko02020,ko04714,map00190,map00860,map01100,map01110,map02020,map04714	M00154	R07412	RC00769	ko00000,ko00001,ko00002,ko03029	3.D.4.4	-	-	COX15-CtaA
HKD2_k127_9174948_0	448385.sce0002	0.0	1112.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria	448385.sce0002|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9174948_13	1254432.SCE1572_14715	4.159e-15	90.0	COG0613@1|root,COG0613@2|Bacteria	2|Bacteria	Q	PHP domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
HKD2_k127_9174948_10	448385.sce8304	7.496e-27	126.0	COG0802@1|root,COG0802@2|Bacteria,1RGYU@1224|Proteobacteria,42VU4@68525|delta/epsilon subdivisions,2WQBA@28221|Deltaproteobacteria,2YW3H@29|Myxococcales	28221|Deltaproteobacteria	S	Threonylcarbamoyl adenosine biosynthesis protein TsaE	yjeE	-	-	ko:K06925	-	-	-	-	ko00000,ko03016	-	-	-	TsaE
HKD2_k127_9174948_1	1192034.CAP_8368	4.492e-129	428.0	COG0682@1|root,COG0682@2|Bacteria,1MVE3@1224|Proteobacteria,42M2I@68525|delta/epsilon subdivisions,2WNPT@28221|Deltaproteobacteria,2YXEG@29|Myxococcales	28221|Deltaproteobacteria	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	-	-	-	ko:K13292	-	-	-	-	ko00000,ko01000	-	-	-	LGT
HKD2_k127_9174948_8	1254432.SCE1572_02980	9.836e-75	260.0	2BQU7@1|root,32JQZ@2|Bacteria,1Q2FE@1224|Proteobacteria,4381B@68525|delta/epsilon subdivisions,2X05S@28221|Deltaproteobacteria,2YV8M@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_FA
HKD2_k127_9174948_9	448385.sce0400	5.772e-33	140.0	COG3266@1|root,COG3266@2|Bacteria,1Q2HB@1224|Proteobacteria,43840@68525|delta/epsilon subdivisions,2X9WR@28221|Deltaproteobacteria,2YVMS@29|Myxococcales	28221|Deltaproteobacteria	S	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9174948_14	1254432.SCE1572_02990	4.45e-13	80.0	COG3266@1|root,COG3266@2|Bacteria,1Q2HB@1224|Proteobacteria,43840@68525|delta/epsilon subdivisions,2X9WR@28221|Deltaproteobacteria,2YVMS@29|Myxococcales	28221|Deltaproteobacteria	S	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9174948_16	591159.ACEZ01000217_gene130	1.258e-06	61.0	COG1541@1|root,COG1541@2|Bacteria	2|Bacteria	H	phenylacetate-CoA ligase activity	-	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding
HKD2_k127_9174948_3	1416759.AYMR01000009_gene3184	1.971e-99	340.0	COG0520@1|root,COG0520@2|Bacteria,2GIVK@201174|Actinobacteria,4FMA5@85023|Microbacteriaceae	201174|Actinobacteria	E	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine	sufS	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	2.8.1.7,4.4.1.16	ko:K11717	ko00450,ko01100,map00450,map01100	-	R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000	-	-	-	Aminotran_5
HKD2_k127_9174948_4	1278073.MYSTI_02776	8.496e-98	341.0	COG0745@1|root,COG0784@1|root,COG4191@1|root,COG0745@2|Bacteria,COG0784@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42PZ5@68525|delta/epsilon subdivisions,2WM5Q@28221|Deltaproteobacteria,2Z2WF@29|Myxococcales	28221|Deltaproteobacteria	T	PAS fold	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_4,PAS_8,PAS_9,Response_reg
HKD2_k127_9174948_7	266117.Rxyl_2372	4.641e-76	260.0	COG0259@1|root,COG0259@2|Bacteria,2GJCR@201174|Actinobacteria,4CQ9H@84995|Rubrobacteria	84995|Rubrobacteria	H	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP)	pdxH	-	1.4.3.5	ko:K00275	ko00750,ko01100,ko01120,map00750,map01100,map01120	M00124	R00277,R00278,R01710,R01711	RC00048,RC00116	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_phzG_C,Putative_PNPOx
HKD2_k127_9185502_0	1192034.CAP_3357	5.867e-127	423.0	COG0515@1|root,COG0515@2|Bacteria,1Q38J@1224|Proteobacteria,438ZJ@68525|delta/epsilon subdivisions,2X44T@28221|Deltaproteobacteria,2YY98@29|Myxococcales	28221|Deltaproteobacteria	KLT	Protein kinase domain	masK	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HKD2_k127_9185502_1	1134474.O59_000004	3.802e-39	154.0	COG3757@1|root,COG3757@2|Bacteria,1N792@1224|Proteobacteria,1S6KA@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	glycoside hydrolase, family	-	-	-	ko:K07273	-	-	-	-	ko00000	-	-	-	Glyco_hydro_25
HKD2_k127_9186680_0	448385.sce0527	1.176e-119	395.0	COG1005@1|root,COG1005@2|Bacteria,1MU2R@1224|Proteobacteria,42MMX@68525|delta/epsilon subdivisions,2WIX8@28221|Deltaproteobacteria,2YUQD@29|Myxococcales	28221|Deltaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	nuoH	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
HKD2_k127_9186680_1	1192034.CAP_0607	1.8e-93	318.0	COG1143@1|root,COG1143@2|Bacteria,1MV90@1224|Proteobacteria,42T2H@68525|delta/epsilon subdivisions,2WRSP@28221|Deltaproteobacteria,2Z31G@29|Myxococcales	28221|Deltaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoI	-	1.6.5.3	ko:K00338	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer4,Fer4_7
HKD2_k127_9186680_2	448385.sce3913	3.243e-57	209.0	COG0457@1|root,COG0515@1|root,COG2956@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG2956@2|Bacteria,1MVIW@1224|Proteobacteria,437VP@68525|delta/epsilon subdivisions,2WWNT@28221|Deltaproteobacteria,2YUC4@29|Myxococcales	28221|Deltaproteobacteria	G	repeat protein	agmK	-	-	-	-	-	-	-	-	-	-	-	Pkinase,TPR_16,TPR_19,TPR_6,TPR_7,TPR_8
HKD2_k127_9188976_0	1192034.CAP_1811	7.899e-238	755.0	COG2206@1|root,COG3437@1|root,COG2206@2|Bacteria,COG3437@2|Bacteria,1MV37@1224|Proteobacteria,42N4N@68525|delta/epsilon subdivisions,2WKJ1@28221|Deltaproteobacteria,2YU9U@29|Myxococcales	28221|Deltaproteobacteria	T	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HD,HD_5
HKD2_k127_9188976_3	1192034.CAP_1552	2.929e-92	329.0	COG0823@1|root,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,PA14,PD40,PKD
HKD2_k127_9188976_4	160860.XP_007351742.1	1.298e-47	191.0	2E2W8@1|root,2SA2G@2759|Eukaryota,3A9FS@33154|Opisthokonta,3P7Z9@4751|Fungi	4751|Fungi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Stig1
HKD2_k127_9188976_2	1192034.CAP_1671	2.038e-107	362.0	COG4284@1|root,COG4284@2|Bacteria,1Q5YI@1224|Proteobacteria,42QK5@68525|delta/epsilon subdivisions,2WKKW@28221|Deltaproteobacteria,2YVJD@29|Myxococcales	28221|Deltaproteobacteria	G	UTP--glucose-1-phosphate uridylyltransferase	-	-	2.7.7.9	ko:K00963	ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130	M00129,M00361,M00362,M00549	R00289	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	UDPGP
HKD2_k127_9188976_5	535289.Dtpsy_3022	1.957e-09	68.0	2DMYI@1|root,32UE4@2|Bacteria,1N1WA@1224|Proteobacteria,2WFYE@28216|Betaproteobacteria,4AEVP@80864|Comamonadaceae	28216|Betaproteobacteria	S	YXWGXW repeat (2 copies)	-	-	-	-	-	-	-	-	-	-	-	-	YXWGXW
HKD2_k127_9188976_1	1254432.SCE1572_10755	1.1e-121	409.0	COG1305@1|root,COG1305@2|Bacteria,1R0BY@1224|Proteobacteria,43DTA@68525|delta/epsilon subdivisions,2X8VQ@28221|Deltaproteobacteria,2Z0KI@29|Myxococcales	28221|Deltaproteobacteria	E	Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Transglut_core
HKD2_k127_9188976_6	1254432.SCE1572_38605	5.881e-09	69.0	COG3825@1|root,COG3825@2|Bacteria,1MUAJ@1224|Proteobacteria,42N7R@68525|delta/epsilon subdivisions,2WJBI@28221|Deltaproteobacteria,2YU57@29|Myxococcales	28221|Deltaproteobacteria	S	VWA domain containing CoxE-like protein	-	-	-	ko:K09989	-	-	-	-	ko00000	-	-	-	VWA_CoxE
HKD2_k127_9214932_6	1303518.CCALI_01218	2.923e-33	147.0	COG1807@1|root,COG1807@2|Bacteria	2|Bacteria	M	4-amino-4-deoxy-L-arabinose transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2,GtrA,PMT_2
HKD2_k127_9214932_8	1461694.ATO9_09705	4.631e-07	63.0	COG1807@1|root,COG1807@2|Bacteria,1Q255@1224|Proteobacteria,2V9M6@28211|Alphaproteobacteria,2PF7E@252301|Oceanicola	28211|Alphaproteobacteria	M	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9214932_9	1088868.CIN_14800	1.456e-06	62.0	COG0666@1|root,COG0666@2|Bacteria,1RE5N@1224|Proteobacteria,2VFA8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Ankyrin repeat	-	-	-	ko:K06867	-	-	-	-	ko00000	-	-	-	Ank_4
HKD2_k127_9214932_4	401053.AciPR4_1956	2.569e-43	183.0	COG1269@1|root,COG1269@2|Bacteria	2|Bacteria	C	ATP hydrolysis coupled proton transport	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HKD2_k127_9214932_0	396588.Tgr7_0087	4.579e-207	676.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,1RNBG@1236|Gammaproteobacteria,1WWSC@135613|Chromatiales	135613|Chromatiales	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
HKD2_k127_9214932_3	448385.sce4512	4.561e-86	301.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,42MVV@68525|delta/epsilon subdivisions,2X4JB@28221|Deltaproteobacteria,2YZ4I@29|Myxococcales	28221|Deltaproteobacteria	KLT	Family membership	-	-	2.7.11.1	ko:K08884	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HKD2_k127_9214932_5	448385.sce1407	1.856e-39	169.0	COG0457@1|root,COG0457@2|Bacteria,1Q9KT@1224|Proteobacteria,43DTC@68525|delta/epsilon subdivisions,2WYTS@28221|Deltaproteobacteria,2Z0KP@29|Myxococcales	28221|Deltaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9214932_2	448385.sce8018	5.019e-91	318.0	COG0515@1|root,COG0515@2|Bacteria	448385.sce8018|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9214932_7	1254432.SCE1572_00330	1.008e-24	118.0	COG3628@1|root,COG3628@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9214932_1	448385.sce8608	5.927e-205	646.0	COG1215@1|root,COG1215@2|Bacteria,1MX08@1224|Proteobacteria,42MS6@68525|delta/epsilon subdivisions,2WIYE@28221|Deltaproteobacteria,2YUMA@29|Myxococcales	28221|Deltaproteobacteria	M	Glycosyl transferase family 21	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3
HKD2_k127_9219417_4	1192034.CAP_3782	3.007e-18	98.0	COG2885@1|root,COG2885@2|Bacteria,1QAG8@1224|Proteobacteria,4352E@68525|delta/epsilon subdivisions,2WZDB@28221|Deltaproteobacteria,2Z1W3@29|Myxococcales	28221|Deltaproteobacteria	M	Belongs to the ompA family	-	-	-	-	-	-	-	-	-	-	-	-	OmpA
HKD2_k127_9219417_3	502025.Hoch_2284	4.22e-32	147.0	COG3119@1|root,COG3119@2|Bacteria,1MV0B@1224|Proteobacteria,43AH9@68525|delta/epsilon subdivisions,2X5XB@28221|Deltaproteobacteria,2Z37F@29|Myxococcales	28221|Deltaproteobacteria	P	Type I phosphodiesterase / nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
HKD2_k127_9219417_5	391587.KAOT1_05847	3.866e-05	57.0	COG2885@1|root,COG2885@2|Bacteria,4NK1N@976|Bacteroidetes,1HY5W@117743|Flavobacteriia	976|Bacteroidetes	M	Thrombospondin type 3 repeat	-	-	-	-	-	-	-	-	-	-	-	-	OMP_b-brl,OmpA,TSP_3
HKD2_k127_9219417_2	85982.XP_007320392.1	4.479e-34	144.0	29MJ0@1|root,2RUV2@2759|Eukaryota,39W7H@33154|Opisthokonta,3NV1P@4751|Fungi,3V4MC@5204|Basidiomycota,22510@155619|Agaricomycetes	4751|Fungi	S	PLC-like phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9219417_0	1192034.CAP_7256	2.476e-78	273.0	COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,42MA7@68525|delta/epsilon subdivisions,2WIPC@28221|Deltaproteobacteria,2YWPY@29|Myxococcales	28221|Deltaproteobacteria	P	Acts as a magnesium transporter	-	-	-	ko:K06213	-	-	-	-	ko00000,ko02000	1.A.26.1	-	-	CBS,MgtE,MgtE_N
HKD2_k127_9227268_0	1487953.JMKF01000045_gene2926	1.717e-175	571.0	COG1073@1|root,COG1073@2|Bacteria,1GBEW@1117|Cyanobacteria	1117|Cyanobacteria	S	alpha beta	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9227268_1	448385.sce8901	2.642e-35	141.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD2_k127_9227268_2	448385.sce5502	6.252e-20	91.0	COG0515@1|root,COG1262@1|root,COG0515@2|Bacteria,COG1262@2|Bacteria,1MZ25@1224|Proteobacteria,42PUT@68525|delta/epsilon subdivisions,2WKN0@28221|Deltaproteobacteria,2YVT8@29|Myxococcales	28221|Deltaproteobacteria	KLT	Sulfatase-modifying factor enzyme 1	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	FGE-sulfatase,Pkinase
HKD2_k127_9229892_0	1192034.CAP_0267	2.013e-155	506.0	COG0515@1|root,COG3899@1|root,COG0515@2|Bacteria,COG3899@2|Bacteria,1MWVZ@1224|Proteobacteria,438G1@68525|delta/epsilon subdivisions,2X3QZ@28221|Deltaproteobacteria,2YWVV@29|Myxococcales	28221|Deltaproteobacteria	KLT	Serine Threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	AAA_16,PEGA,Pkinase,TPR_12
HKD2_k127_9231676_0	1254432.SCE1572_02195	2.605e-157	512.0	COG2812@1|root,COG2812@2|Bacteria,1MVCK@1224|Proteobacteria,42M09@68525|delta/epsilon subdivisions,2WJ1G@28221|Deltaproteobacteria,2YUDA@29|Myxococcales	28221|Deltaproteobacteria	H	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity	dnaX	-	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNA_pol3_gamma3
HKD2_k127_9234191_0	378806.STAUR_2333	3.451e-207	649.0	COG0436@1|root,COG0436@2|Bacteria,1QHKS@1224|Proteobacteria,42Z0T@68525|delta/epsilon subdivisions,2WU4I@28221|Deltaproteobacteria,2YTVA@29|Myxococcales	28221|Deltaproteobacteria	E	Aminotransferase	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
HKD2_k127_9234191_5	246197.MXAN_4998	1.115e-46	172.0	COG3011@1|root,COG3011@2|Bacteria,1N0YV@1224|Proteobacteria,42VUX@68525|delta/epsilon subdivisions,2WW8H@28221|Deltaproteobacteria,2Z1U7@29|Myxococcales	28221|Deltaproteobacteria	S	Protein of unknown function, DUF393	-	-	-	-	-	-	-	-	-	-	-	-	DUF393
HKD2_k127_9234191_1	1254432.SCE1572_40930	1.706e-160	533.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42P6D@68525|delta/epsilon subdivisions,2WM1P@28221|Deltaproteobacteria,2YUD4@29|Myxococcales	28221|Deltaproteobacteria	T	DNA-binding response regulator	-	-	-	ko:K07713	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD2_k127_9234191_7	290397.Adeh_1130	8.313e-20	101.0	COG5002@1|root,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria	1224|Proteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_8
HKD2_k127_9234191_8	1121116.KB894766_gene506	1.299e-12	70.0	COG5487@1|root,COG5487@2|Bacteria,1NGAH@1224|Proteobacteria,2VXNN@28216|Betaproteobacteria,4AFXM@80864|Comamonadaceae	28216|Betaproteobacteria	S	Protein of unknown function (DUF1328)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1328
HKD2_k127_9234191_9	1071679.BG57_07120	7.445e-07	57.0	COG0642@1|root,COG5002@1|root,COG2205@2|Bacteria,COG5002@2|Bacteria,1NRP8@1224|Proteobacteria,2VJI1@28216|Betaproteobacteria,1JZSA@119060|Burkholderiaceae	28216|Betaproteobacteria	T	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg
HKD2_k127_9234191_3	882378.RBRH_03034	4.591e-62	223.0	COG2193@1|root,COG2193@2|Bacteria,1RGH9@1224|Proteobacteria,2WG2W@28216|Betaproteobacteria,1KI8Z@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Rubrerythrin	-	-	1.16.3.1	ko:K03594	ko00860,map00860	-	R00078	RC02758	ko00000,ko00001,ko01000	-	-	-	Ferritin
HKD2_k127_9234191_2	1254432.SCE1572_13460	4.036e-80	278.0	COG3687@1|root,COG3687@2|Bacteria,1R4HJ@1224|Proteobacteria,437ZS@68525|delta/epsilon subdivisions,2X9TG@28221|Deltaproteobacteria,2YV0P@29|Myxococcales	28221|Deltaproteobacteria	S	Predicted metal-dependent hydrolase	-	-	-	ko:K07044	-	-	-	-	ko00000	-	-	-	Metal_hydrol
HKD2_k127_9234191_4	1254432.SCE1572_35015	4.788e-55	199.0	COG1309@1|root,COG1309@2|Bacteria	2|Bacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
HKD2_k127_9234191_6	861299.J421_4448	2.458e-34	139.0	COG0515@1|root,COG0515@2|Bacteria,1ZTGN@142182|Gemmatimonadetes	142182|Gemmatimonadetes	T	Protein kinase domain	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HKD2_k127_9240365_1	1125863.JAFN01000001_gene3329	2.547e-22	106.0	COG2199@1|root,COG2203@1|root,COG2199@2|Bacteria,COG2203@2|Bacteria,1RGKE@1224|Proteobacteria,43CRY@68525|delta/epsilon subdivisions,2X7ZI@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GGDEF
HKD2_k127_9240365_0	358220.C380_11355	7.345e-83	290.0	COG0579@1|root,COG0579@2|Bacteria,1N0QB@1224|Proteobacteria,2VIKG@28216|Betaproteobacteria,4AC8S@80864|Comamonadaceae	28216|Betaproteobacteria	S	Fad dependent oxidoreductase	lhgO	-	1.1.5.3	ko:K00111	ko00564,ko01110,map00564,map01110	-	R00848	RC00029	ko00000,ko00001,ko01000	-	-	-	DAO
HKD2_k127_9240365_2	1121920.AUAU01000021_gene2521	7.21e-08	65.0	COG3809@1|root,COG3809@2|Bacteria,3Y803@57723|Acidobacteria	57723|Acidobacteria	S	Transcription factor zinc-finger	-	-	-	-	-	-	-	-	-	-	-	-	DZR,zf-TFIIB
HKD2_k127_9245280_5	1192034.CAP_0669	0.0004736	52.0	COG2133@1|root,COG2133@2|Bacteria	2|Bacteria	G	pyrroloquinoline quinone binding	-	-	-	-	-	-	-	-	-	-	-	-	Big_5,F5_F8_type_C,PA14,Phosphoesterase
HKD2_k127_9245280_2	502025.Hoch_2209	9.549e-110	369.0	COG0644@1|root,COG0644@2|Bacteria,1QVKV@1224|Proteobacteria	1224|Proteobacteria	C	lycopene cyclase	crtY	-	5.5.1.19	ko:K06443	ko00906,ko01100,ko01110,map00906,map01100,map01110	M00097	R03824,R04801,R05341,R06962,R07856	RC01004,RC01964	ko00000,ko00001,ko00002,ko01000	-	-	-	Lycopene_cycl
HKD2_k127_9245280_3	502025.Hoch_2210	1.559e-70	265.0	COG0142@1|root,COG0142@2|Bacteria,1NXYK@1224|Proteobacteria,430UK@68525|delta/epsilon subdivisions,2WVY1@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	Belongs to the FPP GGPP synthase family	-	-	-	-	-	-	-	-	-	-	-	-	polyprenyl_synt
HKD2_k127_9245280_0	502025.Hoch_2211	3.381e-228	724.0	COG1233@1|root,COG1233@2|Bacteria,1MV2R@1224|Proteobacteria,43BX1@68525|delta/epsilon subdivisions,2X77U@28221|Deltaproteobacteria,2YTZ8@29|Myxococcales	28221|Deltaproteobacteria	Q	Phytoene dehydrogenase	-	-	1.3.99.26,1.3.99.28,1.3.99.29,1.3.99.31	ko:K10027	ko00906,ko01100,ko01110,map00906,map01100,map01110	-	R04787,R04798,R04800,R09691,R09692	RC01214,RC02088,RC02605	ko00000,ko00001,ko01000	-	-	-	Amino_oxidase
HKD2_k127_9245280_4	502025.Hoch_2212	2.735e-59	229.0	COG1562@1|root,COG1562@2|Bacteria,1MX4W@1224|Proteobacteria,430A5@68525|delta/epsilon subdivisions,2WVA4@28221|Deltaproteobacteria,2Z1CK@29|Myxococcales	28221|Deltaproteobacteria	I	PFAM Squalene phytoene synthase	-	-	2.5.1.32,2.5.1.99	ko:K02291	ko00906,ko01062,ko01100,ko01110,map00906,map01062,map01100,map01110	M00097	R02065,R04218,R07270,R10177	RC00362,RC01101,RC02869	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	SQS_PSY
HKD2_k127_9245280_1	502025.Hoch_2162	1.158e-158	521.0	COG1233@1|root,COG3349@1|root,COG4638@1|root,COG1233@2|Bacteria,COG3349@2|Bacteria,COG4638@2|Bacteria,1RAVN@1224|Proteobacteria,433WH@68525|delta/epsilon subdivisions,2X3VQ@28221|Deltaproteobacteria,2YX9K@29|Myxococcales	28221|Deltaproteobacteria	Q	FAD dependent oxidoreductase	-	-	-	ko:K09879	ko00906,map00906	-	R07541,R07560,R07857,R07858	RC01901,RC01965	ko00000,ko00001	-	-	-	Amino_oxidase
HKD2_k127_9255442_5	1192034.CAP_0205	9.406e-73	273.0	COG3284@1|root,COG3284@2|Bacteria	2|Bacteria	KQ	transcription factor binding	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg
HKD2_k127_9255442_25	573370.DMR_21510	1.799e-06	61.0	COG1120@1|root,COG1120@2|Bacteria,1MVKU@1224|Proteobacteria,43ATE@68525|delta/epsilon subdivisions,2X67N@28221|Deltaproteobacteria,2MGY6@213115|Desulfovibrionales	28221|Deltaproteobacteria	HP	ATPases associated with a variety of cellular activities	-	-	3.6.3.34	ko:K02013	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14	-	-	ABC_tran
HKD2_k127_9255442_21	1205753.A989_14477	3.369e-11	75.0	COG0823@1|root,COG0823@2|Bacteria,1MZ1T@1224|Proteobacteria,1RMNE@1236|Gammaproteobacteria,1X6J1@135614|Xanthomonadales	135614|Xanthomonadales	U	WD40-like Beta Propeller Repeat	-	-	-	-	-	-	-	-	-	-	-	-	PD40
HKD2_k127_9255442_8	246194.CHY_0290	1.453e-43	164.0	COG0691@1|root,COG0691@2|Bacteria,1V3IJ@1239|Firmicutes,24HD6@186801|Clostridia,42GC6@68295|Thermoanaerobacterales	186801|Clostridia	J	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene	smpB	-	-	ko:K03664	-	-	-	-	ko00000	-	-	-	SmpB
HKD2_k127_9255442_15	452637.Oter_0673	1.014e-27	121.0	COG0494@1|root,COG0494@2|Bacteria,46VG9@74201|Verrucomicrobia,3K81U@414999|Opitutae	414999|Opitutae	L	NUDIX hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
HKD2_k127_9255442_12	404589.Anae109_1183	8.05e-29	129.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,42RC9@68525|delta/epsilon subdivisions,2WN5U@28221|Deltaproteobacteria,2YWJ8@29|Myxococcales	28221|Deltaproteobacteria	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PEGA,Pkinase
HKD2_k127_9255442_24	1162668.LFE_0663	7.405e-07	59.0	COG3411@1|root,COG3411@2|Bacteria,3J1DT@40117|Nitrospirae	40117|Nitrospirae	C	Ferredoxin	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9255442_19	1254432.SCE1572_38100	3.564e-17	89.0	29XGB@1|root,30J6T@2|Bacteria,1R0DC@1224|Proteobacteria,43CVW@68525|delta/epsilon subdivisions,2X83W@28221|Deltaproteobacteria,2Z2E7@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9255442_1	1192034.CAP_2724	6.272e-141	452.0	COG0115@1|root,COG0115@2|Bacteria,1MVB0@1224|Proteobacteria,42MKX@68525|delta/epsilon subdivisions,2WKXU@28221|Deltaproteobacteria,2YV73@29|Myxococcales	28221|Deltaproteobacteria	E	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family	ilvE	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
HKD2_k127_9255442_10	448385.sce7410	7.869e-36	141.0	COG0724@1|root,COG0724@2|Bacteria,1N6VR@1224|Proteobacteria,43A9U@68525|delta/epsilon subdivisions,2X244@28221|Deltaproteobacteria,2Z171@29|Myxococcales	28221|Deltaproteobacteria	S	Pfam:RRM_6	-	-	-	-	-	-	-	-	-	-	-	-	RRM_1
HKD2_k127_9255442_11	1279015.KB908463_gene2041	2.085e-29	124.0	COG1047@1|root,COG1047@2|Bacteria,1RD35@1224|Proteobacteria,1S3QR@1236|Gammaproteobacteria,1Y4ES@135624|Aeromonadales	135624|Aeromonadales	O	Peptidyl-prolyl cis-trans	slyD	-	5.2.1.8	ko:K03775	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	FKBP_C
HKD2_k127_9255442_14	1379281.AVAG01000011_gene1248	6.838e-28	117.0	2EAFJ@1|root,334IY@2|Bacteria,1NA2Y@1224|Proteobacteria,42VJ1@68525|delta/epsilon subdivisions,2WRKE@28221|Deltaproteobacteria,2MCVH@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF1844)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1844
HKD2_k127_9255442_3	448385.sce7222	2.594e-103	351.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,42NB6@68525|delta/epsilon subdivisions,2WIWE@28221|Deltaproteobacteria,2YYCB@29|Myxococcales	28221|Deltaproteobacteria	M	Domain present in PSD-95, Dlg, and ZO-1/2.	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
HKD2_k127_9255442_4	1254432.SCE1572_42100	3.184e-88	297.0	COG1595@1|root,COG1595@2|Bacteria,1MX7T@1224|Proteobacteria,42U04@68525|delta/epsilon subdivisions,2WQA9@28221|Deltaproteobacteria,2YV9U@29|Myxococcales	28221|Deltaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD2_k127_9255442_13	1499967.BAYZ01000104_gene3641	2.063e-28	117.0	2CGNA@1|root,3301B@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Yippee-Mis18
HKD2_k127_9255442_9	1254432.SCE1572_14625	1.062e-38	157.0	COG3103@1|root,COG3103@2|Bacteria	2|Bacteria	T	Sh3 type 3 domain protein	-	-	3.2.1.17,3.4.17.14	ko:K01185,ko:K07184,ko:K07260	ko00550,ko01100,ko01502,ko02020,map00550,map01100,map01502,map02020	M00651	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504	-	-	-	SH3_3,VanY
HKD2_k127_9255442_18	1192034.CAP_7617	7.957e-18	85.0	COG1722@1|root,COG1722@2|Bacteria,1Q1MN@1224|Proteobacteria,437C8@68525|delta/epsilon subdivisions,2X2HR@28221|Deltaproteobacteria,2YW46@29|Myxococcales	28221|Deltaproteobacteria	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseB	-	3.1.11.6	ko:K03602	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_S
HKD2_k127_9255442_7	1254432.SCE1572_38435	5.509e-51	209.0	COG1413@1|root,COG1413@2|Bacteria	2|Bacteria	C	deoxyhypusine monooxygenase activity	-	-	-	ko:K01932	-	-	-	-	ko00000,ko01000	-	-	-	HEAT_2
HKD2_k127_9255442_23	391625.PPSIR1_07003	6.322e-08	66.0	COG2885@1|root,COG2885@2|Bacteria,1MX1F@1224|Proteobacteria,42UTB@68525|delta/epsilon subdivisions,2WQUW@28221|Deltaproteobacteria,2YUE1@29|Myxococcales	28221|Deltaproteobacteria	M	Belongs to the ompA family	-	-	-	-	-	-	-	-	-	-	-	-	OmpA
HKD2_k127_9255442_6	448385.sce9146	6.885e-67	251.0	COG2885@1|root,COG2885@2|Bacteria,1MX1F@1224|Proteobacteria,42UTB@68525|delta/epsilon subdivisions,2WQUW@28221|Deltaproteobacteria,2YUE1@29|Myxococcales	28221|Deltaproteobacteria	M	Belongs to the ompA family	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Big_3_2,DUF11,OmpA,Phenol_MetA_deg,TSP_3
HKD2_k127_9255442_0	1192034.CAP_6268	2.54e-231	751.0	COG1181@1|root,COG1181@2|Bacteria,1MX3I@1224|Proteobacteria,42SA1@68525|delta/epsilon subdivisions,2WNIR@28221|Deltaproteobacteria,2YU6C@29|Myxococcales	28221|Deltaproteobacteria	F	Belongs to the D-alanine--D-alanine ligase family	-	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C
HKD2_k127_9255442_2	1340493.JNIF01000003_gene2254	4.164e-136	443.0	COG1181@1|root,COG1181@2|Bacteria,3Y9AM@57723|Acidobacteria	57723|Acidobacteria	M	ATP-grasp domain	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_4
HKD2_k127_9258490_3	1184607.AUCHE_24_00190	2.173e-08	59.0	COG0520@1|root,COG0520@2|Bacteria,2GP7W@201174|Actinobacteria	201174|Actinobacteria	E	Aminotransferase class-V	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
HKD2_k127_9258490_2	682795.AciX8_4334	7.41e-14	78.0	2EQUD@1|root,33IE5@2|Bacteria,3Y5Y4@57723|Acidobacteria,2JNQ7@204432|Acidobacteriia	204432|Acidobacteriia	S	YXWGXW repeat (2 copies)	-	-	-	-	-	-	-	-	-	-	-	-	YXWGXW
HKD2_k127_9258490_1	1254432.SCE1572_33325	8.507e-39	163.0	COG0515@1|root,COG1262@1|root,COG0515@2|Bacteria,COG1262@2|Bacteria,1MZ25@1224|Proteobacteria,42PUT@68525|delta/epsilon subdivisions,2WKN0@28221|Deltaproteobacteria,2YVT8@29|Myxococcales	28221|Deltaproteobacteria	KLT	Sulfatase-modifying factor enzyme 1	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	FGE-sulfatase,Pkinase
HKD2_k127_9258490_0	1254432.SCE1572_26045	3.205e-159	509.0	COG1196@1|root,COG1196@2|Bacteria,1R3XQ@1224|Proteobacteria,42YF5@68525|delta/epsilon subdivisions,2WUDV@28221|Deltaproteobacteria,2YUE5@29|Myxococcales	28221|Deltaproteobacteria	D	HAD superfamily (subfamily IG) hydrolase 5'-Nucleotidase	-	-	-	-	-	-	-	-	-	-	-	-	5_nucleotid
HKD2_k127_9263708_4	404589.Anae109_0668	1.18e-100	331.0	COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,42M7F@68525|delta/epsilon subdivisions,2WIMF@28221|Deltaproteobacteria,2YWXD@29|Myxococcales	28221|Deltaproteobacteria	NU	twitching motility protein	pilT-4	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
HKD2_k127_9263708_3	1336243.JAEA01000003_gene2329	1.175e-130	441.0	COG0520@1|root,COG0520@2|Bacteria	2|Bacteria	E	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine	kynU	-	3.7.1.3	ko:K01556	ko00380,ko01100,map00380,map01100	M00038	R00987,R02668,R03936	RC00284,RC00415	ko00000,ko00001,ko00002,ko01000	-	-	-	Aminotran_5
HKD2_k127_9263708_2	1192034.CAP_6588	3.577e-140	462.0	COG0604@1|root,COG0604@2|Bacteria,1MXUX@1224|Proteobacteria,42UGV@68525|delta/epsilon subdivisions,2WR1G@28221|Deltaproteobacteria,2YUDE@29|Myxococcales	28221|Deltaproteobacteria	C	Zinc-binding dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
HKD2_k127_9263708_15	448385.sce7915	3.538e-31	132.0	2AN4Q@1|root,31D2G@2|Bacteria,1QA43@1224|Proteobacteria,434TZ@68525|delta/epsilon subdivisions,2WZ4X@28221|Deltaproteobacteria,2Z1C6@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9263708_14	1254432.SCE1572_37225	1.229e-37	147.0	COG1225@1|root,COG1225@2|Bacteria,1PBT0@1224|Proteobacteria,43838@68525|delta/epsilon subdivisions,2X3D7@28221|Deltaproteobacteria,2YVHY@29|Myxococcales	28221|Deltaproteobacteria	O	Redoxin	-	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
HKD2_k127_9263708_11	1192034.CAP_2721	4.343e-43	171.0	COG3108@1|root,COG3108@2|Bacteria	2|Bacteria	S	Peptidase M15	-	-	-	ko:K02395	-	-	-	-	ko00000,ko02035	-	-	-	Glucosaminidase,Peptidase_M15_2,Peptidase_M15_3,PhageMin_Tail
HKD2_k127_9263708_12	1254432.SCE1572_38125	7.906e-40	154.0	2AIXD@1|root,319F1@2|Bacteria,1Q2IM@1224|Proteobacteria,4385A@68525|delta/epsilon subdivisions,2X3FB@28221|Deltaproteobacteria,2YVU7@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9263708_9	909663.KI867150_gene356	6.257e-49	178.0	COG1490@1|root,COG1490@2|Bacteria,1RGTV@1224|Proteobacteria,42SMU@68525|delta/epsilon subdivisions,2WP4P@28221|Deltaproteobacteria,2MRVA@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality	dtd	GO:0002161,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0051499,GO:0051500,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360	-	ko:K07560	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Tyr_Deacylase
HKD2_k127_9263708_0	1192034.CAP_7480	4.773e-256	802.0	COG0449@1|root,COG0449@2|Bacteria,1MW4K@1224|Proteobacteria,42KZ7@68525|delta/epsilon subdivisions,2WJP6@28221|Deltaproteobacteria,2YU49@29|Myxococcales	28221|Deltaproteobacteria	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	iAF987.Gmet_1487	GATase_6,SIS
HKD2_k127_9263708_7	1192034.CAP_4930	9.219e-69	244.0	COG3591@1|root,COG3591@2|Bacteria	2|Bacteria	E	Belongs to the peptidase S1B family	-	-	-	-	-	-	-	-	-	-	-	-	Trypsin
HKD2_k127_9263708_1	448385.sce8151	3.756e-167	532.0	COG0473@1|root,COG0473@2|Bacteria,1MUH4@1224|Proteobacteria,42M8G@68525|delta/epsilon subdivisions,2WIYB@28221|Deltaproteobacteria,2YZ2Q@29|Myxococcales	28221|Deltaproteobacteria	C	Dehydrogenase	-	-	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
HKD2_k127_9263708_6	1254432.SCE1572_46570	7.521e-83	289.0	COG0318@1|root,COG0318@2|Bacteria,1QXPD@1224|Proteobacteria,43C59@68525|delta/epsilon subdivisions,2WRV5@28221|Deltaproteobacteria,2Z0SY@29|Myxococcales	28221|Deltaproteobacteria	IQ	Acyl-protein synthetase, LuxE	-	-	-	-	-	-	-	-	-	-	-	-	LuxE
HKD2_k127_9263708_5	1192034.CAP_2602	5.289e-96	322.0	COG2220@1|root,COG2220@2|Bacteria,1MV20@1224|Proteobacteria,42PI0@68525|delta/epsilon subdivisions,2WJ79@28221|Deltaproteobacteria,2YUU7@29|Myxococcales	28221|Deltaproteobacteria	S	Zn-dependent hydrolases of the beta-lactamase fold	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
HKD2_k127_9263708_10	1192034.CAP_5535	3.057e-45	169.0	COG1847@1|root,COG1847@2|Bacteria,1RB1P@1224|Proteobacteria,42QPK@68525|delta/epsilon subdivisions,2WN58@28221|Deltaproteobacteria,2YW74@29|Myxococcales	28221|Deltaproteobacteria	S	R3H domain	-	-	-	ko:K06346	-	-	-	-	ko00000	-	-	-	Jag_N,KH_4,R3H
HKD2_k127_9263708_13	1192034.CAP_5534	5.271e-39	151.0	COG0706@1|root,COG0706@2|Bacteria,1MV5M@1224|Proteobacteria,42MS8@68525|delta/epsilon subdivisions,2WJB6@28221|Deltaproteobacteria,2YV0H@29|Myxococcales	28221|Deltaproteobacteria	U	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins	yidC	-	-	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03029	2.A.9	-	-	60KD_IMP,YidC_periplas
HKD2_k127_9272782_0	1192034.CAP_4581	2.768e-125	430.0	COG0810@1|root,COG1629@1|root,COG0810@2|Bacteria,COG4771@2|Bacteria,1R5B9@1224|Proteobacteria,43C1I@68525|delta/epsilon subdivisions,2X7C6@28221|Deltaproteobacteria,2YWPC@29|Myxococcales	28221|Deltaproteobacteria	MP	Periplasmic protein TonB links inner and outer membranes	-	-	-	-	-	-	-	-	-	-	-	-	CarbopepD_reg_2,CarboxypepD_reg,Plug,TonB_C,TonB_dep_Rec
HKD2_k127_9272782_1	1254432.SCE1572_40305	9.503e-73	250.0	COG1181@1|root,COG1181@2|Bacteria,1MUTB@1224|Proteobacteria,42NF2@68525|delta/epsilon subdivisions,2WJ7Q@28221|Deltaproteobacteria,2YUFD@29|Myxococcales	28221|Deltaproteobacteria	F	Belongs to the D-alanine--D-alanine ligase family	ddl	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C,Dala_Dala_lig_N
HKD2_k127_9292810_2	1151117.AJLF01000001_gene1175	7.685e-35	153.0	COG1881@1|root,arCOG04702@2157|Archaea,2XXMX@28890|Euryarchaeota,2440F@183968|Thermococci	183968|Thermococci	S	Phosphatidylethanolamine-binding protein	-	-	-	ko:K06910	-	-	-	-	ko00000	-	-	-	PBP
HKD2_k127_9292810_0	1192034.CAP_6141	3.092e-110	373.0	COG1807@1|root,COG1807@2|Bacteria,1Q2FK@1224|Proteobacteria,4381I@68525|delta/epsilon subdivisions,2X3BM@28221|Deltaproteobacteria,2YUUG@29|Myxococcales	28221|Deltaproteobacteria	M	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9292810_1	1254432.SCE1572_22895	1.781e-51	185.0	COG1716@1|root,COG4962@1|root,COG1716@2|Bacteria,COG4962@2|Bacteria,1R7EN@1224|Proteobacteria,42NAK@68525|delta/epsilon subdivisions,2WIYX@28221|Deltaproteobacteria,2YTSI@29|Myxococcales	28221|Deltaproteobacteria	TU	Type II IV secretion system protein	-	-	-	ko:K02283,ko:K03609	-	-	-	-	ko00000,ko02035,ko02044,ko03036,ko04812	-	-	-	CbiA,FHA,T2SSE
HKD2_k127_9293765_0	448385.sce9052	1.221e-172	558.0	COG0323@1|root,COG0323@2|Bacteria,1MV61@1224|Proteobacteria,42MFX@68525|delta/epsilon subdivisions,2WJ91@28221|Deltaproteobacteria,2YU35@29|Myxococcales	28221|Deltaproteobacteria	L	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex	mutL	GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391	-	ko:K03572	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	DNA_mis_repair,HATPase_c_3,MutL_C
HKD2_k127_929626_6	1254432.SCE1572_22735	1.076e-89	297.0	COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,42M4I@68525|delta/epsilon subdivisions,2WJHM@28221|Deltaproteobacteria,2YY9M@29|Myxococcales	28221|Deltaproteobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
HKD2_k127_929626_12	1254432.SCE1572_22740	7.249e-54	208.0	COG1734@1|root,COG1734@2|Bacteria,1N8RB@1224|Proteobacteria,42W5H@68525|delta/epsilon subdivisions,2WSAD@28221|Deltaproteobacteria,2YVJ6@29|Myxococcales	28221|Deltaproteobacteria	T	Prokaryotic dksA/traR C4-type zinc finger	dksA	-	-	ko:K06204	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000,ko03009,ko03021	-	-	-	zf-dskA_traR
HKD2_k127_929626_7	1254432.SCE1572_45965	1.403e-85	294.0	COG0164@1|root,COG0164@2|Bacteria	2|Bacteria	L	RNA-DNA hybrid ribonuclease activity	-	-	3.1.26.4	ko:K03470	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_HII
HKD2_k127_929626_20	56780.SYN_01761	3.483e-05	55.0	COG4970@1|root,COG4970@2|Bacteria	2|Bacteria	NU	protein transport across the cell outer membrane	-	-	-	ko:K02246,ko:K08084	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.15.2	-	-	GspH,N_methyl
HKD2_k127_929626_16	1254432.SCE1572_12340	1.753e-14	87.0	COG4967@1|root,COG4967@2|Bacteria	2|Bacteria	NU	type IV pilus modification protein PilV	pilV-1	-	-	ko:K02671,ko:K02681	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	N_methyl
HKD2_k127_929626_14	1254432.SCE1572_12335	1.37e-28	133.0	COG4966@1|root,COG4966@2|Bacteria	2|Bacteria	NU	pilus assembly protein PilW	-	-	-	ko:K02672	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	N_methyl
HKD2_k127_929626_0	1192034.CAP_7919	6.576e-195	653.0	COG3419@1|root,COG3419@2|Bacteria,1NUAV@1224|Proteobacteria,42NJ7@68525|delta/epsilon subdivisions,2WJYB@28221|Deltaproteobacteria,2YW3S@29|Myxococcales	28221|Deltaproteobacteria	NU	Tfp pilus assembly protein tip-associated adhesin	-	-	-	ko:K02674	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	Neisseria_PilC
HKD2_k127_929626_21	349521.HCH_00961	0.0001327	53.0	COG3391@1|root,COG3391@2|Bacteria,1RJQF@1224|Proteobacteria,1S6KV@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_929626_8	926566.Terro_1937	2.796e-82	299.0	COG2374@1|root,COG2374@2|Bacteria,3Y6CB@57723|Acidobacteria,2JMEK@204432|Acidobacteriia	204432|Acidobacteriia	S	Endonuclease Exonuclease Phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_929626_3	1254432.SCE1572_40075	8.371e-108	359.0	COG2996@1|root,COG2996@2|Bacteria,1MXC3@1224|Proteobacteria,42P2A@68525|delta/epsilon subdivisions,2WKAS@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	S1 domain	-	-	-	ko:K00243	-	-	-	-	ko00000	-	-	-	S1_2
HKD2_k127_929626_10	378806.STAUR_6882	6.41e-80	286.0	COG3509@1|root,COG3509@2|Bacteria,1N6M6@1224|Proteobacteria,42U8Z@68525|delta/epsilon subdivisions,2WQQT@28221|Deltaproteobacteria,2YV47@29|Myxococcales	28221|Deltaproteobacteria	Q	Esterase PHB depolymerase	-	-	-	ko:K03932	-	-	-	-	ko00000	-	CE1	-	Esterase,Esterase_phd,Peptidase_S9,RicinB_lectin_2
HKD2_k127_929626_18	1279038.KB907345_gene3409	1.446e-09	66.0	COG1309@1|root,COG1309@2|Bacteria,1RGQQ@1224|Proteobacteria,2UF97@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
HKD2_k127_929626_5	1254432.SCE1572_07895	9.537e-101	347.0	COG2244@1|root,COG2244@2|Bacteria,1QT9H@1224|Proteobacteria,439PF@68525|delta/epsilon subdivisions,2X50Z@28221|Deltaproteobacteria,2YZYN@29|Myxococcales	28221|Deltaproteobacteria	S	polysaccharide biosynthetic process	-	-	-	ko:K06409	-	-	-	-	ko00000,ko02000	2.A.66.2.14	-	-	Polysacc_synt
HKD2_k127_929626_2	1254432.SCE1572_26290	4.869e-113	385.0	COG0668@1|root,COG0668@2|Bacteria	2|Bacteria	M	transmembrane transport	-	-	-	ko:K03442,ko:K22044	-	-	-	-	ko00000,ko02000	1.A.23.2,1.A.23.3	-	-	LysM,MS_channel,Mu-transpos_C,rve
HKD2_k127_929626_9	1254432.SCE1572_26285	8.083e-81	286.0	COG0475@1|root,COG0475@2|Bacteria,1R0CR@1224|Proteobacteria,43CV9@68525|delta/epsilon subdivisions,2X836@28221|Deltaproteobacteria,2Z3JX@29|Myxococcales	28221|Deltaproteobacteria	P	Sodium/hydrogen exchanger family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
HKD2_k127_929626_1	1254432.SCE1572_26280	1.368e-137	452.0	COG0475@1|root,COG0475@2|Bacteria,1R9PF@1224|Proteobacteria,42RF1@68525|delta/epsilon subdivisions,2WMJJ@28221|Deltaproteobacteria,2Z31T@29|Myxococcales	28221|Deltaproteobacteria	P	Sodium/hydrogen exchanger family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger,PTS_EIIA_2,TrkA_C,TrkA_N
HKD2_k127_929626_13	1278078.G419_10046	4.283e-40	155.0	COG0454@1|root,COG0456@2|Bacteria,2I9Y3@201174|Actinobacteria,4G0P0@85025|Nocardiaceae	201174|Actinobacteria	K	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HKD2_k127_929626_4	1242864.D187_002751	2.811e-101	333.0	COG0024@1|root,COG0024@2|Bacteria,1MU99@1224|Proteobacteria,42MM5@68525|delta/epsilon subdivisions,2WJMN@28221|Deltaproteobacteria,2YU2H@29|Myxococcales	28221|Deltaproteobacteria	J	Methionine aminopeptidase	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24,SEC-C
HKD2_k127_9296526_0	1192034.CAP_3584	2.961e-262	814.0	COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,42N6D@68525|delta/epsilon subdivisions,2X5IJ@28221|Deltaproteobacteria,2YWT3@29|Myxococcales	28221|Deltaproteobacteria	I	Carboxyl transferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Carboxyl_trans
HKD2_k127_9296526_2	1144275.COCOR_06948	4.976e-10	68.0	COG3055@1|root,COG3055@2|Bacteria,1QT4U@1224|Proteobacteria,437RQ@68525|delta/epsilon subdivisions,2X4KF@28221|Deltaproteobacteria,2YZ72@29|Myxococcales	28221|Deltaproteobacteria	E	M6 family metalloprotease domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9296526_1	448385.sce2445	4.676e-61	230.0	COG4786@1|root,COG4786@2|Bacteria	2|Bacteria	N	Flagellar basal body rod	flgK	-	-	ko:K02396	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	DUF2950,Flg_bb_rod,Flg_bbr_C
HKD2_k127_9299180_2	269798.CHU_2059	7.562e-51	199.0	COG3239@1|root,COG3239@2|Bacteria,4NHPQ@976|Bacteroidetes,47KXE@768503|Cytophagia	976|Bacteroidetes	I	Fatty acid desaturase	-	-	-	-	-	-	-	-	-	-	-	-	FA_desaturase
HKD2_k127_9299180_3	246197.MXAN_1269	3.508e-11	77.0	COG1752@1|root,COG1752@2|Bacteria,1Q9RI@1224|Proteobacteria,434JD@68525|delta/epsilon subdivisions,2X8X1@28221|Deltaproteobacteria,2Z0T6@29|Myxococcales	28221|Deltaproteobacteria	S	Patatin-like phospholipase	-	-	-	-	-	-	-	-	-	-	-	-	Patatin
HKD2_k127_9299180_0	1254432.SCE1572_30845	6.133e-163	525.0	COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,42M0V@68525|delta/epsilon subdivisions,2WIQ1@28221|Deltaproteobacteria,2YU4J@29|Myxococcales	28221|Deltaproteobacteria	C	FAD linked oxidases, C-terminal domain	glcD	-	1.1.2.4,1.1.3.15	ko:K00102,ko:K00104	ko00620,ko00630,ko01100,ko01110,ko01120,ko01130,map00620,map00630,map01100,map01110,map01120,map01130	-	R00197,R00475	RC00042,RC00044	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
HKD2_k127_9299180_1	1254432.SCE1572_38600	4.531e-93	311.0	COG0714@1|root,COG0714@2|Bacteria,1MV5I@1224|Proteobacteria,42MTW@68525|delta/epsilon subdivisions,2WJ0J@28221|Deltaproteobacteria,2YUI8@29|Myxococcales	28221|Deltaproteobacteria	S	ATPase family associated with various cellular activities (AAA)	-	-	-	-	-	-	-	-	-	-	-	-	AAA,AAA_5
HKD2_k127_9318161_6	1144275.COCOR_03128	3.95e-63	231.0	COG2197@1|root,COG2197@2|Bacteria,1MWGM@1224|Proteobacteria,42Q40@68525|delta/epsilon subdivisions,2WKJ7@28221|Deltaproteobacteria,2Z0RB@29|Myxococcales	28221|Deltaproteobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HKD2_k127_9318161_9	926560.KE387023_gene3856	1.495e-54	207.0	COG4585@1|root,COG4585@2|Bacteria,1WK2H@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HisKA_3
HKD2_k127_9318161_2	448385.sce2377	2.264e-125	419.0	COG1640@1|root,COG1640@2|Bacteria,1QTVJ@1224|Proteobacteria,42PZB@68525|delta/epsilon subdivisions,2WK77@28221|Deltaproteobacteria,2YVA7@29|Myxococcales	28221|Deltaproteobacteria	G	4-alpha-glucanotransferase	malQ	-	2.4.1.25	ko:K00705	ko00500,ko01100,map00500,map01100	-	R05196	RC00049	ko00000,ko00001,ko01000	-	GH77	-	Glyco_hydro_77
HKD2_k127_9318161_1	448385.sce8524	1.037e-140	454.0	COG0150@1|root,COG0150@2|Bacteria,1MURG@1224|Proteobacteria,42KZT@68525|delta/epsilon subdivisions,2WIXY@28221|Deltaproteobacteria,2YTTG@29|Myxococcales	28221|Deltaproteobacteria	F	Phosphoribosylformylglycinamidine cyclo-ligase	purM	-	6.3.3.1	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04208	RC01100	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_1844	AIRS,AIRS_C
HKD2_k127_9318161_5	448385.sce8521	5.532e-64	241.0	COG0299@1|root,COG0299@2|Bacteria,1MWN1@1224|Proteobacteria,42R30@68525|delta/epsilon subdivisions,2WJT0@28221|Deltaproteobacteria,2YVC1@29|Myxococcales	28221|Deltaproteobacteria	F	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate	purN	-	2.1.2.2	ko:K11175	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	M00048	R04325,R04326	RC00026,RC00197,RC01128	ko00000,ko00001,ko00002,ko01000	-	-	-	Formyl_trans_N
HKD2_k127_9318161_4	622637.KE124774_gene2921	4.157e-96	324.0	COG4638@1|root,COG4638@2|Bacteria,1MX47@1224|Proteobacteria,2TV03@28211|Alphaproteobacteria,36Z27@31993|Methylocystaceae	28211|Alphaproteobacteria	P	Rieske [2Fe-2S] domain	-	-	-	-	-	-	-	-	-	-	-	-	Rieske
HKD2_k127_9318161_10	448385.sce0578	9.995e-39	162.0	COG3054@1|root,COG3054@2|Bacteria,1Q8NR@1224|Proteobacteria,43883@68525|delta/epsilon subdivisions,2X3HU@28221|Deltaproteobacteria,2YW60@29|Myxococcales	28221|Deltaproteobacteria	S	Bacterial protein of unknown function (YtfJ_HI0045)	-	-	-	ko:K07109	-	-	-	-	ko00000	-	-	-	YtfJ_HI0045
HKD2_k127_9318161_7	391625.PPSIR1_32949	8.806e-62	224.0	COG0789@1|root,COG5012@1|root,COG0789@2|Bacteria,COG5012@2|Bacteria,1R9SN@1224|Proteobacteria,42X6D@68525|delta/epsilon subdivisions,2WSP0@28221|Deltaproteobacteria,2YVHJ@29|Myxococcales	28221|Deltaproteobacteria	K	helix_turn_helix, mercury resistance	-	-	-	ko:K22491	-	-	-	-	ko00000,ko03000	-	-	-	B12-binding,B12-binding_2,MerR_1
HKD2_k127_9318161_0	448385.sce0580	3.231e-235	736.0	COG1233@1|root,COG1233@2|Bacteria,1MV2R@1224|Proteobacteria,43BX1@68525|delta/epsilon subdivisions,2X77U@28221|Deltaproteobacteria,2YTZ8@29|Myxococcales	28221|Deltaproteobacteria	Q	Phytoene dehydrogenase	-	-	1.3.99.26,1.3.99.28,1.3.99.29,1.3.99.31	ko:K10027	ko00906,ko01100,ko01110,map00906,map01100,map01110	-	R04787,R04798,R04800,R09691,R09692	RC01214,RC02088,RC02605	ko00000,ko00001,ko01000	-	-	-	Amino_oxidase
HKD2_k127_9318161_3	448385.sce0581	8.301e-97	328.0	COG1562@1|root,COG1562@2|Bacteria,1MX4W@1224|Proteobacteria,4383X@68525|delta/epsilon subdivisions,2X0HZ@28221|Deltaproteobacteria,2YVMG@29|Myxococcales	28221|Deltaproteobacteria	I	Squalene/phytoene synthase	crtB	-	2.5.1.32,2.5.1.99	ko:K02291	ko00906,ko01062,ko01100,ko01110,map00906,map01062,map01100,map01110	M00097	R02065,R04218,R07270,R10177	RC00362,RC01101,RC02869	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	SQS_PSY
HKD2_k127_9318161_8	1192034.CAP_5217	1.755e-56	205.0	COG0204@1|root,COG0204@2|Bacteria,1R787@1224|Proteobacteria,439C7@68525|delta/epsilon subdivisions,2X4KB@28221|Deltaproteobacteria,2YZ6U@29|Myxococcales	28221|Deltaproteobacteria	I	Phosphate acyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Acyltransferase
HKD2_k127_9318636_2	1192034.CAP_1905	5e-119	397.0	COG0515@1|root,COG2110@1|root,COG0515@2|Bacteria,COG2110@2|Bacteria	2|Bacteria	P	phosphatase homologous to the C-terminal domain of histone macroH2A1	tfaE	GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Caudo_TAP,Macro
HKD2_k127_9318636_0	1192034.CAP_4064	1.753e-155	514.0	COG3291@1|root,COG3291@2|Bacteria	2|Bacteria	S	metallopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	CBM60,CHU_C,Glyco_hydro_8,IgGFc_binding,PA14,PKD,PQQ,PQQ_2,fn3
HKD2_k127_9318636_1	1192034.CAP_4064	6.464e-147	486.0	COG3291@1|root,COG3291@2|Bacteria	2|Bacteria	S	metallopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	CBM60,CHU_C,Glyco_hydro_8,IgGFc_binding,PA14,PKD,PQQ,PQQ_2,fn3
HKD2_k127_9318636_3	1192034.CAP_4064	1.755e-67	235.0	COG3291@1|root,COG3291@2|Bacteria	2|Bacteria	S	metallopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	CBM60,CHU_C,Glyco_hydro_8,IgGFc_binding,PA14,PKD,PQQ,PQQ_2,fn3
HKD2_k127_9318730_1	448385.sce2422	6.325e-160	520.0	COG0308@1|root,COG0308@2|Bacteria,1P5AT@1224|Proteobacteria,433TV@68525|delta/epsilon subdivisions,2X3FG@28221|Deltaproteobacteria,2YVV0@29|Myxococcales	28221|Deltaproteobacteria	E	Peptidase family M1 domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M1
HKD2_k127_9318730_3	378806.STAUR_5717	5.049e-89	317.0	COG1533@1|root,COG1533@2|Bacteria,1MW0H@1224|Proteobacteria,42U5B@68525|delta/epsilon subdivisions,2WQVN@28221|Deltaproteobacteria,2YWFF@29|Myxococcales	28221|Deltaproteobacteria	L	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
HKD2_k127_9318730_8	1254432.SCE1572_35745	3.124e-07	58.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2YTW0@29|Myxococcales	28221|Deltaproteobacteria	T	response regulator	-	-	-	ko:K02481,ko:K07713	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD2_k127_9318730_0	448385.sce4390	2.157e-318	992.0	COG0542@1|root,COG0542@2|Bacteria,1MV8B@1224|Proteobacteria,42M2T@68525|delta/epsilon subdivisions,2WJ2W@28221|Deltaproteobacteria,2YUIP@29|Myxococcales	28221|Deltaproteobacteria	O	Belongs to the ClpA ClpB family	clpA	-	-	ko:K03694	-	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
HKD2_k127_9318730_5	448385.sce4389	1.924e-30	139.0	COG2127@1|root,COG2127@2|Bacteria,1MZU8@1224|Proteobacteria,42TN3@68525|delta/epsilon subdivisions,2WQ23@28221|Deltaproteobacteria,2YVP9@29|Myxococcales	28221|Deltaproteobacteria	S	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation	clpS	-	-	ko:K06891	-	-	-	-	ko00000	-	-	-	ClpS
HKD2_k127_9318730_2	448385.sce3829	7.31e-101	346.0	COG0515@1|root,COG0515@2|Bacteria	448385.sce3829|-	KLT	protein kinase activity	-	-	2.7.11.1	ko:K08884	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	-
HKD2_k127_9318730_4	1254432.SCE1572_00345	2.93e-48	181.0	2EI76@1|root,33BYI@2|Bacteria,1RBW7@1224|Proteobacteria,42QZD@68525|delta/epsilon subdivisions,2WN6J@28221|Deltaproteobacteria,2YXMN@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9318730_6	376686.Fjoh_1071	1.234e-16	87.0	COG0534@1|root,COG0534@2|Bacteria,4NDUF@976|Bacteroidetes,1HX7D@117743|Flavobacteriia,2NS74@237|Flavobacterium	976|Bacteroidetes	V	Multidrug transporter MatE	-	-	-	ko:K03327	-	-	-	-	ko00000,ko02000	2.A.66.1	-	-	MatE
HKD2_k127_9323690_1	1192034.CAP_2703	1.287e-80	275.0	COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,42MHD@68525|delta/epsilon subdivisions,2WTUX@28221|Deltaproteobacteria,2YTTM@29|Myxococcales	28221|Deltaproteobacteria	M	Belongs to the peptidase S41A family	-	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_S41
HKD2_k127_9323690_2	1121861.KB899912_gene1102	4.073e-74	257.0	COG0854@1|root,COG0854@2|Bacteria,1MU9W@1224|Proteobacteria,2TTTF@28211|Alphaproteobacteria,2JPM4@204441|Rhodospirillales	204441|Rhodospirillales	H	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate	pdxJ	-	2.6.99.2	ko:K03474	ko00750,ko01100,map00750,map01100	M00124	R05838	RC01476	ko00000,ko00001,ko00002,ko01000	-	-	-	PdxJ
HKD2_k127_9323690_3	1254432.SCE1572_02530	6.13e-32	139.0	COG0736@1|root,COG0736@2|Bacteria,1MZBF@1224|Proteobacteria,42TWY@68525|delta/epsilon subdivisions,2WRSQ@28221|Deltaproteobacteria,2Z1VF@29|Myxococcales	28221|Deltaproteobacteria	I	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein	acpS	-	2.7.8.7	ko:K00997	ko00770,map00770	-	R01625	RC00002	ko00000,ko00001,ko01000	-	-	-	ACPS
HKD2_k127_9323690_0	1254432.SCE1572_02535	7.999e-98	334.0	COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,1MU1Q@1224|Proteobacteria,42ND6@68525|delta/epsilon subdivisions,2WIJS@28221|Deltaproteobacteria,2YURF@29|Myxococcales	28221|Deltaproteobacteria	H	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	-	4.2.1.136,5.1.99.6	ko:K17758,ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	Carb_kinase,YjeF_N
HKD2_k127_9331022_5	448385.sce3834	6.114e-109	360.0	COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,42N0H@68525|delta/epsilon subdivisions,2WK9P@28221|Deltaproteobacteria,2YU0X@29|Myxococcales	28221|Deltaproteobacteria	S	Insulinase (Peptidase family M16)	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
HKD2_k127_9331022_4	1254432.SCE1572_23005	7.991e-136	459.0	COG0612@1|root,COG0612@2|Bacteria,1MU6R@1224|Proteobacteria,42M74@68525|delta/epsilon subdivisions,2WR3G@28221|Deltaproteobacteria,2YXS5@29|Myxococcales	28221|Deltaproteobacteria	S	Insulinase (Peptidase family M16)	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
HKD2_k127_9331022_6	1032480.MLP_13840	1.836e-78	288.0	COG1052@1|root,COG1052@2|Bacteria,2I2RK@201174|Actinobacteria,4DWPF@85009|Propionibacteriales	201174|Actinobacteria	CH	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain	-	-	1.1.1.26	ko:K00015	ko00630,ko01100,ko01110,ko01120,map00630,map01100,map01110,map01120	-	R00717,R01388	RC00031,RC00042	ko00000,ko00001,ko01000	-	-	-	2-Hacid_dh,2-Hacid_dh_C
HKD2_k127_9331022_1	1254432.SCE1572_24000	1.626e-177	573.0	COG0443@1|root,COG0443@2|Bacteria,1MVEN@1224|Proteobacteria,42M64@68525|delta/epsilon subdivisions	1224|Proteobacteria	O	Heat shock 70 kDa protein	-	-	-	-	-	-	-	-	-	-	-	-	HSP70
HKD2_k127_9331022_2	1192034.CAP_5597	1.056e-174	561.0	COG0439@1|root,COG0439@2|Bacteria,1MU4H@1224|Proteobacteria,42M14@68525|delta/epsilon subdivisions,2WIN7@28221|Deltaproteobacteria,2Z3K0@29|Myxococcales	28221|Deltaproteobacteria	I	Biotin carboxylase	accC	-	6.3.4.14,6.4.1.2,6.4.1.4	ko:K01961,ko:K01968	ko00061,ko00280,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00280,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00036,M00082,M00376	R00742,R04138,R04385	RC00040,RC00253,RC00367,RC00942	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
HKD2_k127_9331022_0	330214.NIDE1804	4.982e-295	938.0	COG3696@1|root,COG3696@2|Bacteria,3J0ZR@40117|Nitrospirae	40117|Nitrospirae	P	AcrB/AcrD/AcrF family	-	-	-	ko:K15726	-	-	-	-	ko00000,ko02000	2.A.6.1.2	-	-	ACR_tran
HKD2_k127_9331022_9	1266925.JHVX01000001_gene2796	2.029e-40	167.0	COG0845@1|root,COG0845@2|Bacteria,1R4E4@1224|Proteobacteria,2VN9E@28216|Betaproteobacteria,372UC@32003|Nitrosomonadales	28216|Betaproteobacteria	M	HlyD family secretion protein	-	-	-	ko:K15727	-	-	-	-	ko00000,ko02000	8.A.1.2.1	-	-	HlyD_D23
HKD2_k127_9331022_10	857087.Metme_1001	2.189e-28	130.0	COG1538@1|root,COG1538@2|Bacteria,1R744@1224|Proteobacteria,1SZYN@1236|Gammaproteobacteria,1XGYJ@135618|Methylococcales	135618|Methylococcales	MU	Outer membrane efflux protein	-	-	-	ko:K15725	-	-	-	-	ko00000,ko02000	1.B.17.2.2	-	-	OEP
HKD2_k127_9331022_8	1192034.CAP_3893	6.619e-53	202.0	COG1075@1|root,COG4786@1|root,COG1075@2|Bacteria,COG4786@2|Bacteria	2|Bacteria	N	Flagellar basal body rod	flgK	-	1.1.3.6	ko:K02396,ko:K03333	ko00984,ko01120,ko02040,map00984,map01120,map02040	-	R01459	RC00146	ko00000,ko00001,ko01000,ko02035	-	-	-	DUF2950,Flg_bb_rod,Flg_bbr_C
HKD2_k127_9331022_3	404589.Anae109_2770	1.614e-143	464.0	COG1697@1|root,COG1697@2|Bacteria,1NBFJ@1224|Proteobacteria,4314R@68525|delta/epsilon subdivisions,2WWNC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	DNA topoisomerase VI subunit A	top6A	-	5.99.1.3	ko:K03166	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	TP6A_N
HKD2_k127_9331022_7	290397.Adeh_2840	1.388e-59	216.0	COG1389@1|root,COG1389@2|Bacteria,1R6T0@1224|Proteobacteria,42YI1@68525|delta/epsilon subdivisions,2WTHV@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	Relaxes both positive and negative superturns and exhibits a strong decatenase activity	top6B	-	5.99.1.3	ko:K03167	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	HATPase_c,HATPase_c_3,Topo-VIb_trans
HKD2_k127_9332575_5	290315.Clim_2258	4.711e-53	199.0	COG4585@1|root,COG4585@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	-	ko:K03406,ko:K21470	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko01002,ko01011,ko02035	-	-	-	DUF4325,HATPase_c,HisKA_3
HKD2_k127_9332575_2	383372.Rcas_0264	6.735e-70	256.0	COG5184@1|root,COG5184@2|Bacteria,2G8WU@200795|Chloroflexi,3765G@32061|Chloroflexia	32061|Chloroflexia	DZ	PFAM regulator of chromosome condensation, RCC1	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9332575_6	391625.PPSIR1_19804	6.137e-46	176.0	28ZS2@1|root,2ZMGV@2|Bacteria,1Q9PN@1224|Proteobacteria,434I5@68525|delta/epsilon subdivisions,2X8WM@28221|Deltaproteobacteria,2Z0QQ@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	CAP
HKD2_k127_9332575_3	1242969.ATCC51562_1201	1.04e-65	257.0	COG0790@1|root,COG0790@2|Bacteria,1MWPA@1224|Proteobacteria,42M5H@68525|delta/epsilon subdivisions,2YTMF@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	S	Sel1-like repeats.	-	-	-	ko:K07126	-	-	-	-	ko00000	-	-	-	Sel1
HKD2_k127_9332575_0	266264.Rmet_2202	1.309e-254	807.0	COG0654@1|root,COG1902@1|root,COG0654@2|Bacteria,COG1902@2|Bacteria,1MVE0@1224|Proteobacteria,2VHDY@28216|Betaproteobacteria,1K008@119060|Burkholderiaceae	28216|Betaproteobacteria	CH	Catalyzes the conversion of salicylyl-CoA to gentisyl-CoA	abmA	-	1.14.13.40,1.3.1.34	ko:K00219,ko:K09461	ko00627,ko01120,map00627,map01120	-	R03998,R03999	RC00244	ko00000,ko00001,ko01000	-	-	-	FAD_binding_3,Oxidored_FMN
HKD2_k127_9332575_4	1192034.CAP_1969	4.507e-64	226.0	COG1028@1|root,COG1028@2|Bacteria,1N8G3@1224|Proteobacteria,439VQ@68525|delta/epsilon subdivisions,2X59T@28221|Deltaproteobacteria,2Z0B2@29|Myxococcales	28221|Deltaproteobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9332575_1	1192034.CAP_5909	1.709e-144	473.0	COG3291@1|root,COG3291@2|Bacteria,1QEIS@1224|Proteobacteria,4389M@68525|delta/epsilon subdivisions,2X3J1@28221|Deltaproteobacteria,2YWAB@29|Myxococcales	28221|Deltaproteobacteria	S	IgGFc binding protein	-	-	-	-	-	-	-	-	-	-	-	-	IgGFc_binding
HKD2_k127_9349189_1	1254432.SCE1572_23030	2.403e-68	241.0	COG2849@1|root,COG2849@2|Bacteria,1RJWA@1224|Proteobacteria,42VHV@68525|delta/epsilon subdivisions,2WRR0@28221|Deltaproteobacteria,2YVQD@29|Myxococcales	28221|Deltaproteobacteria	S	repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9349189_2	1192034.CAP_6496	6.196e-48	174.0	COG0662@1|root,COG0662@2|Bacteria,1NADF@1224|Proteobacteria,4383M@68525|delta/epsilon subdivisions,2X9WE@28221|Deltaproteobacteria,2YVKF@29|Myxococcales	28221|Deltaproteobacteria	G	Mannose-6-phosphate isomerase	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HKD2_k127_9349189_0	448385.sce3840	1.421e-104	349.0	COG1187@1|root,COG1187@2|Bacteria,1MUCE@1224|Proteobacteria,42NI7@68525|delta/epsilon subdivisions,2WNPX@28221|Deltaproteobacteria,2YUXM@29|Myxococcales	28221|Deltaproteobacteria	J	Belongs to the pseudouridine synthase RsuA family	rluB	-	5.4.99.21,5.4.99.22	ko:K06178,ko:K06182	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
HKD2_k127_93535_0	1254432.SCE1572_43985	1.446e-226	720.0	COG1874@1|root,COG1874@2|Bacteria,1NDQP@1224|Proteobacteria,4388G@68525|delta/epsilon subdivisions,2X3I5@28221|Deltaproteobacteria,2YW75@29|Myxococcales	28221|Deltaproteobacteria	G	Belongs to the glycosyl hydrolase 35 family	-	-	3.2.1.23	ko:K12308	ko00052,map00052	-	R01105	RC00452	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_35
HKD2_k127_93535_7	28564.XP_002477883.1	5.867e-15	80.0	KOG1218@1|root,KOG1218@2759|Eukaryota	2759|Eukaryota	S	negative regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment	-	-	-	-	-	-	-	-	-	-	-	-	EB,TIL
HKD2_k127_93535_8	38033.XP_001225480.1	1.654e-08	61.0	COG1184@1|root,KOG1467@2759|Eukaryota,38CIH@33154|Opisthokonta,3NV2M@4751|Fungi,3QPPP@4890|Ascomycota,2118D@147550|Sordariomycetes,3U5ET@5139|Sordariales,3HBGU@35718|Chaetomiaceae	4751|Fungi	J	Belongs to the eIF-2B alpha beta delta subunits family	tif224	GO:0002181,GO:0002183,GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005085,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005851,GO:0006412,GO:0006413,GO:0006417,GO:0006446,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010608,GO:0019222,GO:0019538,GO:0019899,GO:0030234,GO:0031323,GO:0031326,GO:0032045,GO:0032268,GO:0032991,GO:0034248,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050790,GO:0050794,GO:0051020,GO:0051171,GO:0051246,GO:0060255,GO:0065007,GO:0065009,GO:0071704,GO:0080090,GO:0097159,GO:0098772,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:2000112	-	ko:K03680	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	IF-2B
HKD2_k127_93535_2	1254432.SCE1572_49385	5.199e-98	330.0	COG3178@1|root,COG3178@2|Bacteria,1MXCH@1224|Proteobacteria,42TUJ@68525|delta/epsilon subdivisions,2WQ4U@28221|Deltaproteobacteria,2YX6A@29|Myxococcales	28221|Deltaproteobacteria	S	Choline/ethanolamine kinase	-	-	2.7.1.221	ko:K07102	ko00520,ko01100,map00520,map01100	-	R08968,R11024	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	APH
HKD2_k127_93535_5	1254432.SCE1572_49310	2.079e-35	151.0	COG0357@1|root,COG0357@2|Bacteria,1MY0K@1224|Proteobacteria,42SB8@68525|delta/epsilon subdivisions,2WPKF@28221|Deltaproteobacteria,2YZGS@29|Myxococcales	28221|Deltaproteobacteria	J	Specifically methylates the N7 position of guanine in position 527 of 16S rRNA	rsmG	-	2.1.1.170	ko:K03501	-	-	-	-	ko00000,ko01000,ko03009,ko03036	-	-	-	GidB
HKD2_k127_93535_9	448385.sce0423	1.673e-07	64.0	COG1807@1|root,COG1807@2|Bacteria,1R4F0@1224|Proteobacteria	1224|Proteobacteria	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HKD2_k127_93535_4	290397.Adeh_1135	5.118e-60	229.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,42RC9@68525|delta/epsilon subdivisions,2WN5U@28221|Deltaproteobacteria,2YWJ8@29|Myxococcales	28221|Deltaproteobacteria	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PEGA,Pkinase
HKD2_k127_93535_6	246197.MXAN_6412	5.638e-27	122.0	COG1413@1|root,COG1413@2|Bacteria	2|Bacteria	C	deoxyhypusine monooxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2
HKD2_k127_93535_1	1192034.CAP_8827	2.831e-145	495.0	COG1193@1|root,COG1193@2|Bacteria,1NX1A@1224|Proteobacteria,4305V@68525|delta/epsilon subdivisions,2WV73@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	Protein-arginine deiminase (PAD) middle domain	-	-	-	-	-	-	-	-	-	-	-	-	PAD
HKD2_k127_93535_3	1254432.SCE1572_48445	9.002e-75	253.0	COG0479@1|root,COG0479@2|Bacteria,1MVHS@1224|Proteobacteria,42M2J@68525|delta/epsilon subdivisions,2WJMH@28221|Deltaproteobacteria,2YWFJ@29|Myxococcales	28221|Deltaproteobacteria	C	2Fe-2S iron-sulfur cluster binding domain	sdhB	-	1.3.5.1,1.3.5.4	ko:K00240,ko:K00245	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020	M00009,M00011,M00149,M00150,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_3,Fer4_10,Fer4_8
HKD2_k127_93564_0	243231.GSU2782	2.271e-124	405.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJ8D@28221|Deltaproteobacteria,43S5E@69541|Desulfuromonadales	28221|Deltaproteobacteria	V	AcrB/AcrD/AcrF family	-	-	-	ko:K03296,ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
HKD2_k127_93564_1	278957.ABEA03000197_gene423	1.026e-89	308.0	COG0845@1|root,COG0845@2|Bacteria,46U1B@74201|Verrucomicrobia,3K78A@414999|Opitutae	414999|Opitutae	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	HlyD_D23
HKD2_k127_9376238_0	1278073.MYSTI_02998	0.0	1019.0	COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,42M4I@68525|delta/epsilon subdivisions,2WJHM@28221|Deltaproteobacteria,2YUJ6@29|Myxococcales	28221|Deltaproteobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
HKD2_k127_9376238_2	118161.KB235922_gene3040	1.32e-55	198.0	COG0386@1|root,COG0386@2|Bacteria,1G47I@1117|Cyanobacteria,3VKD1@52604|Pleurocapsales	1117|Cyanobacteria	O	Belongs to the glutathione peroxidase family	btuE	-	1.11.1.22,1.11.1.9	ko:K00432,ko:K20207	ko00480,ko00590,ko04918,map00480,map00590,map04918	-	R00274,R07034,R07035	RC00011,RC00982	ko00000,ko00001,ko01000	-	-	iJN678.slr1171	GSHPx
HKD2_k127_9376238_3	1094558.ME5_00176	0.000455	49.0	COG1846@1|root,COG1846@2|Bacteria,1N690@1224|Proteobacteria,2UE3Y@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	ko:K06075	-	-	-	-	ko00000,ko03000	-	-	-	MarR,MarR_2
HKD2_k127_9376238_1	1254432.SCE1572_30425	2.063e-84	287.0	COG1012@1|root,COG1012@2|Bacteria,1NZKP@1224|Proteobacteria,434QK@68525|delta/epsilon subdivisions,2WZ1Y@28221|Deltaproteobacteria,2Z15C@29|Myxococcales	28221|Deltaproteobacteria	C	Aldehyde dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Aldedh
HKD2_k127_9376947_7	595460.RRSWK_05813	0.0004873	46.0	COG3809@1|root,COG3809@2|Bacteria	2|Bacteria	S	Transcription factor zinc-finger	-	-	-	ko:K09981	-	-	-	-	ko00000	-	-	-	zf-TFIIB
HKD2_k127_9376947_4	1292034.OR37_00475	6.483e-66	238.0	COG1028@1|root,COG1028@2|Bacteria,1PFUB@1224|Proteobacteria,2U1ZJ@28211|Alphaproteobacteria,2KHTA@204458|Caulobacterales	204458|Caulobacterales	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HKD2_k127_9376947_1	1254432.SCE1572_44100	1.983e-146	477.0	COG0773@1|root,COG0773@2|Bacteria,1MUC5@1224|Proteobacteria,42NMY@68525|delta/epsilon subdivisions,2WJ8S@28221|Deltaproteobacteria,2YU74@29|Myxococcales	28221|Deltaproteobacteria	M	Mur ligase family, catalytic domain	mpl	-	6.3.2.45	ko:K02558	-	-	-	-	ko00000,ko01000	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
HKD2_k127_9376947_2	1192034.CAP_7197	3.711e-101	344.0	COG0181@1|root,COG0181@2|Bacteria,1MU56@1224|Proteobacteria,42M84@68525|delta/epsilon subdivisions,2WJ5V@28221|Deltaproteobacteria,2YUZ3@29|Myxococcales	28221|Deltaproteobacteria	H	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps	hemC	GO:0003674,GO:0003824,GO:0004418,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.61	ko:K01749	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00084	RC02317	ko00000,ko00001,ko00002,ko01000	-	-	-	Porphobil_deam,Porphobil_deamC
HKD2_k127_9376947_6	43354.JOIJ01000007_gene1652	2.02e-07	61.0	COG0400@1|root,COG0400@2|Bacteria,2INMY@201174|Actinobacteria,4E2TT@85010|Pseudonocardiales	201174|Actinobacteria	S	PFAM Phospholipase Carboxylesterase	-	-	-	ko:K06999	-	-	-	-	ko00000	-	-	-	Abhydrolase_2,DLH
HKD2_k127_9376947_5	1234664.AMRO01000076_gene2476	3.948e-34	149.0	COG1171@1|root,COG1171@2|Bacteria,1TP22@1239|Firmicutes,4H9NK@91061|Bacilli,1WFDS@129337|Geobacillus	91061|Bacilli	E	Pyridoxal-phosphate dependent enzyme	-	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,ACT_4,PALP
HKD2_k127_9376947_3	1192034.CAP_8057	1.26e-71	255.0	COG0572@1|root,COG0572@2|Bacteria,1MWCH@1224|Proteobacteria,42T0E@68525|delta/epsilon subdivisions,2WPTV@28221|Deltaproteobacteria,2YUY9@29|Myxococcales	28221|Deltaproteobacteria	F	Phosphoribulokinase / Uridine kinase family	udk	-	2.7.1.19,2.7.1.48	ko:K00855,ko:K00876	ko00240,ko00710,ko00983,ko01100,ko01120,ko01200,map00240,map00710,map00983,map01100,map01120,map01200	M00165,M00166	R00513,R00516,R00517,R00962,R00964,R00967,R00968,R00970,R01523,R01548,R01549,R01880,R02091,R02096,R02097,R02327,R02332,R02371,R02372,R08232	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PRK
HKD2_k127_9376947_0	448385.sce0412	7.157e-188	606.0	COG0745@1|root,COG3437@1|root,COG3667@1|root,COG0745@2|Bacteria,COG3437@2|Bacteria,COG3667@2|Bacteria,1QXU5@1224|Proteobacteria,43C6N@68525|delta/epsilon subdivisions,2X7GW@28221|Deltaproteobacteria,2YUUA@29|Myxococcales	28221|Deltaproteobacteria	T	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4388,HD_5,Response_reg,T2SSE_N
HKD2_k127_9378685_1	1254432.SCE1572_20425	6.651e-153	509.0	COG0823@1|root,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,PA14,PD40,PKD
HKD2_k127_9378685_5	448385.sce1052	6.22e-91	309.0	2BT1V@1|root,32N66@2|Bacteria,1QAJD@1224|Proteobacteria,43E1N@68525|delta/epsilon subdivisions,2WZFU@28221|Deltaproteobacteria,2Z21P@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9378685_3	448385.sce1053	1.256e-119	394.0	2ARW7@1|root,31H81@2|Bacteria,1QEXJ@1224|Proteobacteria,439J5@68525|delta/epsilon subdivisions,2X4VQ@28221|Deltaproteobacteria,2YZPU@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9378685_7	448385.sce0397	1.145e-55	214.0	COG0139@1|root,COG0140@1|root,COG0139@2|Bacteria,COG0140@2|Bacteria,1MW67@1224|Proteobacteria,42SGH@68525|delta/epsilon subdivisions,2WP2B@28221|Deltaproteobacteria,2YVE2@29|Myxococcales	28221|Deltaproteobacteria	E	Histidine biosynthesis bifunctional protein HisIE	hisI	-	3.5.4.19,3.6.1.31	ko:K01496,ko:K11755	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04035,R04037	RC00002,RC01055	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_1897	PRA-CH,PRA-PH
HKD2_k127_9378685_6	1192034.CAP_2505	8.836e-87	313.0	COG0745@1|root,COG1196@1|root,COG0745@2|Bacteria,COG1196@2|Bacteria,1QXA6@1224|Proteobacteria,43E4U@68525|delta/epsilon subdivisions,2X7E9@28221|Deltaproteobacteria,2YVVM@29|Myxococcales	28221|Deltaproteobacteria	DKT	Response regulator receiver domain	frzS	-	-	-	-	-	-	-	-	-	-	-	Response_reg
HKD2_k127_9378685_14	448385.sce5864	0.0004861	48.0	COG0745@1|root,COG1196@1|root,COG0745@2|Bacteria,COG1196@2|Bacteria,1QXA6@1224|Proteobacteria,43E4U@68525|delta/epsilon subdivisions,2X7E9@28221|Deltaproteobacteria,2YVVM@29|Myxococcales	28221|Deltaproteobacteria	DKT	Response regulator receiver domain	frzS	-	-	-	-	-	-	-	-	-	-	-	Response_reg
HKD2_k127_9378685_2	378806.STAUR_6366	2.598e-123	409.0	COG0402@1|root,COG0402@2|Bacteria,1MVPA@1224|Proteobacteria,42NI6@68525|delta/epsilon subdivisions,2WKI1@28221|Deltaproteobacteria,2YYX4@29|Myxococcales	28221|Deltaproteobacteria	F	Amidohydrolase family	-	-	3.5.4.28,3.5.4.31	ko:K12960	ko00270,ko01100,map00270,map01100	-	R09660	RC00477	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
HKD2_k127_9378685_4	1192034.CAP_1661	2.128e-117	393.0	COG0784@1|root,COG0784@2|Bacteria,1QAM7@1224|Proteobacteria,43563@68525|delta/epsilon subdivisions,2WZH3@28221|Deltaproteobacteria,2Z24X@29|Myxococcales	28221|Deltaproteobacteria	T	Domain of unknown function (DUF4388)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4388,Response_reg
HKD2_k127_9378685_13	1041146.ATZB01000008_gene2073	1.546e-06	60.0	COG0840@1|root,COG0840@2|Bacteria,1NRGZ@1224|Proteobacteria,2UQ9H@28211|Alphaproteobacteria,4B9XF@82115|Rhizobiaceae	28211|Alphaproteobacteria	NT	chemotaxis protein	mcpE	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	MCPsignal,Protoglobin
HKD2_k127_9378685_8	1123060.JONP01000012_gene2728	1.818e-46	192.0	COG0643@1|root,COG0643@2|Bacteria,1MUAG@1224|Proteobacteria,2U501@28211|Alphaproteobacteria,2JVVV@204441|Rhodospirillales	204441|Rhodospirillales	NT	Two component signalling adaptor domain	-	-	-	-	-	-	-	-	-	-	-	-	CheW,HATPase_c,Hpt
HKD2_k127_9378685_9	448385.sce7253	5.504e-39	154.0	COG0454@1|root,COG0456@2|Bacteria,1RIE6@1224|Proteobacteria,42V77@68525|delta/epsilon subdivisions,2WRQF@28221|Deltaproteobacteria,2YVTX@29|Myxococcales	28221|Deltaproteobacteria	K	FR47-like protein	rimI	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1
HKD2_k127_9378685_0	448385.sce1684	1.767e-235	761.0	COG0457@1|root,COG0457@2|Bacteria,1Q385@1224|Proteobacteria,433YW@68525|delta/epsilon subdivisions,2X44A@28221|Deltaproteobacteria,2YY7W@29|Myxococcales	28221|Deltaproteobacteria	E	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16
HKD2_k127_9378685_10	656024.FsymDg_0630	7.732e-22	102.0	COG1487@1|root,COG1487@2|Bacteria,2IS29@201174|Actinobacteria,4EVPK@85013|Frankiales	201174|Actinobacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	vapC	-	-	ko:K07062	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PIN
HKD2_k127_9378685_12	240016.ABIZ01000001_gene267	4.487e-11	66.0	2FJ9A@1|root,34AZB@2|Bacteria,46W48@74201|Verrucomicrobia	74201|Verrucomicrobia	S	SpoVT / AbrB like domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9378685_11	1123229.AUBC01000016_gene4243	1.031e-19	101.0	2DQV4@1|root,338VU@2|Bacteria,1R05U@1224|Proteobacteria	1224|Proteobacteria	S	Right handed beta helix region	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix
HKD2_k127_9381504_0	448385.sce6907	3.051e-108	353.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,42QAU@68525|delta/epsilon subdivisions,2WMD2@28221|Deltaproteobacteria,2YUNE@29|Myxococcales	28221|Deltaproteobacteria	C	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	ko:K11731	ko00281,map00281	-	R08089	RC01893	ko00000,ko00001,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HKD2_k127_9381504_2	1192034.CAP_0058	9.852e-92	311.0	COG0451@1|root,COG0451@2|Bacteria,1MW32@1224|Proteobacteria,42NJT@68525|delta/epsilon subdivisions,2WM7E@28221|Deltaproteobacteria,2YXN2@29|Myxococcales	28221|Deltaproteobacteria	GM	epimerase dehydratase	hpnA	-	1.1.1.219	ko:K00091	-	-	-	-	ko00000,ko01000	-	-	-	Epimerase
HKD2_k127_9381504_9	550540.Fbal_3197	0.0005153	50.0	COG2197@1|root,COG2197@2|Bacteria,1RCMT@1224|Proteobacteria,1S21K@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE
HKD2_k127_9381504_1	1125863.JAFN01000001_gene2253	4.943e-106	359.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	ko:K02481,ko:K07713	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD2_k127_9381504_7	502025.Hoch_6875	7.696e-25	112.0	COG0745@1|root,COG0745@2|Bacteria,1RKDZ@1224|Proteobacteria,43F04@68525|delta/epsilon subdivisions,2WYKX@28221|Deltaproteobacteria,2Z1YF@29|Myxococcales	28221|Deltaproteobacteria	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
HKD2_k127_9381504_5	1254432.SCE1572_22830	1.008e-33	138.0	COG0545@1|root,COG0545@2|Bacteria,1RDA1@1224|Proteobacteria,42TNB@68525|delta/epsilon subdivisions,2WQIG@28221|Deltaproteobacteria,2Z0TE@29|Myxococcales	28221|Deltaproteobacteria	O	FKBP-type peptidyl-prolyl cis-trans isomerase	-	-	5.2.1.8	ko:K01802,ko:K03772	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	FKBP_C
HKD2_k127_9381504_3	1144275.COCOR_02085	4.908e-67	245.0	COG3016@1|root,COG3016@2|Bacteria,1MX1I@1224|Proteobacteria,42U2R@68525|delta/epsilon subdivisions,2WM9S@28221|Deltaproteobacteria,2YZVS@29|Myxococcales	28221|Deltaproteobacteria	S	Haem-binding uptake, Tiki superfamily, ChaN	-	-	-	-	-	-	-	-	-	-	-	-	Cofac_haem_bdg,PDZ_2
HKD2_k127_9381504_4	1192034.CAP_4849	9.488e-53	200.0	COG0625@1|root,COG0625@2|Bacteria,1RG4U@1224|Proteobacteria,43DV7@68525|delta/epsilon subdivisions,2WYYQ@28221|Deltaproteobacteria,2Z0Y3@29|Myxococcales	28221|Deltaproteobacteria	O	Glutathione S-transferase, C-terminal domain	-	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C,GST_C_2,GST_N_3
HKD2_k127_9381504_6	867903.ThesuDRAFT_01318	2.501e-30	124.0	COG3255@1|root,COG3255@2|Bacteria,1V7IH@1239|Firmicutes	1239|Firmicutes	I	SCP-2 sterol transfer family	-	-	-	-	-	-	-	-	-	-	-	-	SCP2
HKD2_k127_9395102_8	985054.JQEZ01000007_gene513	5.735e-07	60.0	COG0790@1|root,COG0790@2|Bacteria,1MWPA@1224|Proteobacteria,2TR2B@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Sel1 domain protein repeat-containing protein	-	-	-	ko:K07126	-	-	-	-	ko00000	-	-	-	Sel1
HKD2_k127_9395102_2	448385.sce7934	3.67e-51	198.0	2A4SV@1|root,30TE9@2|Bacteria,1PD77@1224|Proteobacteria,435ER@68525|delta/epsilon subdivisions,2WZSB@28221|Deltaproteobacteria,2Z2N4@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9395102_4	448385.sce7933	1.947e-34	140.0	COG1254@1|root,COG1254@2|Bacteria,1N6NU@1224|Proteobacteria,42V8V@68525|delta/epsilon subdivisions,2WRKG@28221|Deltaproteobacteria,2Z0Y9@29|Myxococcales	28221|Deltaproteobacteria	C	acylphosphatase activity	acyP	GO:0003674,GO:0003824,GO:0003998,GO:0016787,GO:0016817,GO:0016818	3.6.1.7	ko:K01512	ko00620,ko00627,ko01120,map00620,map00627,map01120	-	R00317,R01421,R01515	RC00043	ko00000,ko00001,ko01000	-	-	-	Acylphosphatase
HKD2_k127_9395102_5	483219.LILAB_32760	1.304e-32	145.0	COG0774@1|root,COG0774@2|Bacteria,1MV6T@1224|Proteobacteria,42MVM@68525|delta/epsilon subdivisions,2WJ4I@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis	lpxC	-	3.5.1.108	ko:K02535,ko:K13599	ko00540,ko01100,ko02020,map00540,map01100,map02020	M00060,M00498	R04587	RC00166,RC00300	ko00000,ko00001,ko00002,ko01000,ko01005,ko02022	-	-	-	LpxC
HKD2_k127_9395102_1	1254432.SCE1572_51690	7.238e-104	359.0	COG0604@1|root,COG0604@2|Bacteria,1MX8A@1224|Proteobacteria,42PGW@68525|delta/epsilon subdivisions,2WMMZ@28221|Deltaproteobacteria,2YUHA@29|Myxococcales	28221|Deltaproteobacteria	C	NAD(P)H quinone oxidoreductase, PIG3 family	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
HKD2_k127_9395102_3	318464.IO99_00960	5.457e-50	188.0	COG0705@1|root,COG0705@2|Bacteria,1TSBP@1239|Firmicutes,249D8@186801|Clostridia,36FUY@31979|Clostridiaceae	186801|Clostridia	S	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
HKD2_k127_9395102_0	1192034.CAP_4601	8.103e-128	436.0	2DYJ3@1|root,34A1W@2|Bacteria,1PDJB@1224|Proteobacteria,435GY@68525|delta/epsilon subdivisions,2X99N@28221|Deltaproteobacteria,2Z2SE@29|Myxococcales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF3570)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3570
HKD2_k127_9406359_1	1192034.CAP_1957	2.73e-14	85.0	COG2885@1|root,COG2885@2|Bacteria,1R4WG@1224|Proteobacteria,42TD5@68525|delta/epsilon subdivisions,2WP3U@28221|Deltaproteobacteria,2YZG5@29|Myxococcales	28221|Deltaproteobacteria	M	OmpA family	-	-	-	ko:K03286	-	-	-	-	ko00000,ko02000	1.B.6	-	-	OMP_b-brl,OmpA,TSP_3
HKD2_k127_9406359_0	1288494.EBAPG3_24030	5.139e-57	202.0	COG3659@1|root,COG3659@2|Bacteria,1Q8C7@1224|Proteobacteria,2VJFC@28216|Betaproteobacteria,371UJ@32003|Nitrosomonadales	28216|Betaproteobacteria	M	Carbohydrate-selective porin, OprB family	oprB	-	-	-	-	-	-	-	-	-	-	-	OprB
HKD2_k127_9457167_3	391625.PPSIR1_42049	1.055e-33	136.0	COG4786@1|root,COG4786@2|Bacteria	2|Bacteria	N	Flagellar basal body rod	flgK	-	-	ko:K02396	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	DUF2950,Flg_bb_rod,Flg_bbr_C
HKD2_k127_9457167_0	1488328.JMCL01000029_gene4992	8.806e-136	450.0	COG2303@1|root,COG2303@2|Bacteria,1P9UF@1224|Proteobacteria,1RPS8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GMC_oxred_C,GMC_oxred_N
HKD2_k127_9457167_6	296587.XP_002506925.1	7.656e-08	66.0	KOG4363@1|root,KOG4363@2759|Eukaryota,3841I@33090|Viridiplantae,34MK3@3041|Chlorophyta	3041|Chlorophyta	S	Insulin-induced protein (INSIG)	-	-	-	-	-	-	-	-	-	-	-	-	INSIG
HKD2_k127_9457167_1	246197.MXAN_1901	7.143e-43	162.0	COG3293@1|root,COG3293@2|Bacteria,1NCPP@1224|Proteobacteria	1224|Proteobacteria	L	Transposase proposed to express due to -1 translational frameshift at the sequence 5'-AAAAAC-3'	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF4096
HKD2_k127_9457167_5	42256.RradSPS_2099	3.311e-18	91.0	COG3293@1|root,COG3293@2|Bacteria,2IKID@201174|Actinobacteria	201174|Actinobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4096
HKD2_k127_9457167_2	290397.Adeh_0078	6.712e-41	159.0	2A9VF@1|root,30Z3B@2|Bacteria,1PKZS@1224|Proteobacteria,435JG@68525|delta/epsilon subdivisions,2WZXJ@28221|Deltaproteobacteria,2Z0YG@29|Myxococcales	290397.Adeh_0078|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9476101_0	404589.Anae109_3774	1.145e-06	61.0	COG0457@1|root,COG0457@2|Bacteria,1PXHP@1224|Proteobacteria,434K6@68525|delta/epsilon subdivisions,2WYXE@28221|Deltaproteobacteria,2Z0V1@29|Myxococcales	28221|Deltaproteobacteria	S	TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	PEGA,TPR_16
HKD2_k127_9488295_6	1254432.SCE1572_38620	5.728e-52	192.0	COG1032@1|root,COG5011@1|root,COG1032@2|Bacteria,COG5011@2|Bacteria,1MV5G@1224|Proteobacteria,42MPT@68525|delta/epsilon subdivisions,2WJG9@28221|Deltaproteobacteria,2YUJ4@29|Myxococcales	28221|Deltaproteobacteria	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	DUF2344,Radical_SAM
HKD2_k127_9488295_8	502025.Hoch_3397	3.388e-21	103.0	2EKVR@1|root,33EJ9@2|Bacteria,1Q2HX@1224|Proteobacteria,4384Q@68525|delta/epsilon subdivisions,2X9XE@28221|Deltaproteobacteria,2YVRC@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9488295_2	448385.sce4785	5.011e-82	283.0	COG3568@1|root,COG3568@2|Bacteria,1NJUY@1224|Proteobacteria,432E7@68525|delta/epsilon subdivisions,2WXI5@28221|Deltaproteobacteria,2YVNS@29|Myxococcales	28221|Deltaproteobacteria	S	Endonuclease/Exonuclease/phosphatase family	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
HKD2_k127_9488295_5	1242864.D187_004718	3.349e-57	221.0	COG0730@1|root,COG0730@2|Bacteria,1MXNM@1224|Proteobacteria,42KZF@68525|delta/epsilon subdivisions,2WPGW@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
HKD2_k127_9488295_7	1144275.COCOR_06523	5.053e-23	109.0	COG3221@1|root,COG3221@2|Bacteria,1MXD8@1224|Proteobacteria,42VZ4@68525|delta/epsilon subdivisions,2WRDI@28221|Deltaproteobacteria,2YW4T@29|Myxococcales	28221|Deltaproteobacteria	P	ABC transporter, phosphonate, periplasmic substrate-binding protein	phnD	-	-	ko:K02044	ko02010,map02010	M00223	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.9	-	-	Phosphonate-bd
HKD2_k127_9488295_0	1254432.SCE1572_06065	1.345e-138	463.0	COG0793@1|root,COG0793@2|Bacteria	2|Bacteria	M	Belongs to the peptidase S41A family	-	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_S41
HKD2_k127_9488295_3	448385.sce0858	9.509e-82	281.0	COG0568@1|root,COG0568@2|Bacteria,1MVWR@1224|Proteobacteria,42NRM@68525|delta/epsilon subdivisions,2WJ0S@28221|Deltaproteobacteria,2YZ27@29|Myxococcales	28221|Deltaproteobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	-	-	-	ko:K03089	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r4
HKD2_k127_9488295_1	448385.sce0378	1.566e-116	415.0	COG0616@1|root,COG0616@2|Bacteria,1MUXE@1224|Proteobacteria,42MNA@68525|delta/epsilon subdivisions,2X3SJ@28221|Deltaproteobacteria,2YX0A@29|Myxococcales	28221|Deltaproteobacteria	OU	Signal peptide peptidase	sppA	-	-	ko:K04773	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S49
HKD2_k127_9488295_4	1254432.SCE1572_02420	1.633e-60	211.0	COG0494@1|root,COG0494@2|Bacteria,1RCZM@1224|Proteobacteria,42T10@68525|delta/epsilon subdivisions,2WPNN@28221|Deltaproteobacteria,2YVNK@29|Myxococcales	28221|Deltaproteobacteria	L	Nudix hydrolase	-	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX,NUDIX_4
HKD2_k127_9488295_9	1192034.CAP_5847	6.57e-11	63.0	COG1716@1|root,COG1716@2|Bacteria,1Q2GC@1224|Proteobacteria,4382T@68525|delta/epsilon subdivisions,2X0C6@28221|Deltaproteobacteria,2YVG7@29|Myxococcales	28221|Deltaproteobacteria	T	Forkhead associated domain	-	-	-	-	-	-	-	-	-	-	-	-	FHA
HKD2_k127_9510082_0	2340.JV46_28720	1.598e-150	489.0	COG0468@1|root,COG0468@2|Bacteria,1MU3C@1224|Proteobacteria,1RMHP@1236|Gammaproteobacteria,1J536@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage	recA	GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006928,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009314,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0010212,GO:0031668,GO:0033554,GO:0034641,GO:0040011,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048870,GO:0050896,GO:0051179,GO:0051674,GO:0051716,GO:0071496,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363	-	ko:K03553	ko03440,map03440	M00729	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	RecA
HKD2_k127_9510082_2	1254432.SCE1572_35460	1.603e-21	101.0	COG2062@1|root,COG2062@2|Bacteria	2|Bacteria	T	phosphohistidine phosphatase, SixA	sixA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0071704,GO:1901564	-	ko:K08296	-	-	-	-	ko00000,ko01000	-	-	-	His_Phos_1
HKD2_k127_9510082_1	1192034.CAP_8841	8.966e-63	223.0	COG1451@1|root,COG1451@2|Bacteria,1P1X1@1224|Proteobacteria,4314C@68525|delta/epsilon subdivisions,2X3BB@28221|Deltaproteobacteria,2YV83@29|Myxococcales	28221|Deltaproteobacteria	S	nucleotide metabolic process	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9530688_1	1254432.SCE1572_32970	3.874e-50	185.0	COG0406@1|root,COG0406@2|Bacteria,1NPC4@1224|Proteobacteria,434AF@68525|delta/epsilon subdivisions,2X23S@28221|Deltaproteobacteria,2YVSR@29|Myxococcales	28221|Deltaproteobacteria	G	Belongs to the phosphoglycerate mutase family	-	-	5.4.2.12	ko:K15634	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	His_Phos_1
HKD2_k127_9530688_4	1192034.CAP_4226	4.969e-05	53.0	COG1876@1|root,COG1876@2|Bacteria	2|Bacteria	M	D-alanyl-D-alanine carboxypeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Amidase_3,Glucosaminidase,Glyco_hydro_19,PG_binding_1,SLT,TMP_2,VanY
HKD2_k127_9530688_2	448385.sce7258	7.928e-29	117.0	COG1758@1|root,COG1758@2|Bacteria,1N6TX@1224|Proteobacteria,42V07@68525|delta/epsilon subdivisions,2WRQ6@28221|Deltaproteobacteria,2YW65@29|Myxococcales	28221|Deltaproteobacteria	K	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits	rpoZ	-	2.7.7.6	ko:K03060	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb6
HKD2_k127_9530688_0	1192034.CAP_8509	2.997e-88	302.0	COG0500@1|root,COG0500@2|Bacteria,1R0DM@1224|Proteobacteria,43CW7@68525|delta/epsilon subdivisions,2X847@28221|Deltaproteobacteria,2Z3KJ@29|Myxococcales	28221|Deltaproteobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
HKD2_k127_9530688_3	1242864.D187_006090	2.449e-25	114.0	COG0325@1|root,COG0325@2|Bacteria,1MWN7@1224|Proteobacteria,42PSG@68525|delta/epsilon subdivisions,2WKYN@28221|Deltaproteobacteria,2YZQW@29|Myxococcales	28221|Deltaproteobacteria	S	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis	yggS	-	-	ko:K06997	-	-	-	-	ko00000	-	-	-	Ala_racemase_N
HKD2_k127_9533957_3	1254432.SCE1572_23420	2.658e-16	94.0	COG2067@1|root,COG2067@2|Bacteria,1P67N@1224|Proteobacteria	2|Bacteria	I	long-chain fatty acid transport protein	-	-	-	ko:K06076	-	-	-	-	ko00000,ko02000	1.B.9	-	-	Toluene_X
HKD2_k127_9533957_4	1192034.CAP_6990	5.482e-10	72.0	COG2067@1|root,COG2067@2|Bacteria	2|Bacteria	I	long-chain fatty acid transporting porin activity	-	-	-	ko:K06076	-	-	-	-	ko00000,ko02000	1.B.9	-	-	Toluene_X
HKD2_k127_9533957_2	1254432.SCE1572_51265	2.703e-68	242.0	COG0824@1|root,COG0824@2|Bacteria	2|Bacteria	IQ	Thioesterase	-	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT,Acyl_transf_1,GSDH,KR,Ketoacyl-synt_C,PS-DH,Recombinase,Resolvase,Zn_ribbon_recom,ketoacyl-synt
HKD2_k127_9533957_1	378806.STAUR_3164	1.641e-100	340.0	COG0845@1|root,COG0845@2|Bacteria,1MW65@1224|Proteobacteria,42PI8@68525|delta/epsilon subdivisions,2WMFS@28221|Deltaproteobacteria,2YZYC@29|Myxococcales	28221|Deltaproteobacteria	M	Biotin-lipoyl like	-	-	-	ko:K07799	ko02020,map02020	M00648	-	-	ko00000,ko00001,ko00002,ko02000	8.A.1	-	-	Biotin_lipoyl_2,HlyD_D23
HKD2_k127_9533957_0	378806.STAUR_3163	2.881e-130	428.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42NNB@68525|delta/epsilon subdivisions,2WMAU@28221|Deltaproteobacteria,2YXK5@29|Myxococcales	28221|Deltaproteobacteria	V	AcrB/AcrD/AcrF family	-	-	-	ko:K07788	ko02020,map02020	M00648	-	-	ko00000,ko00001,ko00002,ko02000	2.A.6.2	-	-	ACR_tran
HKD2_k127_9551256_1	215803.DB30_7342	3.415e-98	326.0	COG0583@1|root,COG0583@2|Bacteria,1QSDA@1224|Proteobacteria,437HU@68525|delta/epsilon subdivisions,2X2RC@28221|Deltaproteobacteria,2YUEZ@29|Myxococcales	28221|Deltaproteobacteria	K	LysR substrate binding domain	-	-	-	ko:K18297	-	M00641,M00745	-	-	ko00000,ko00002,ko01504,ko03000	-	-	-	HTH_1,LysR_substrate
HKD2_k127_9551256_0	448385.sce8849	1.941e-133	432.0	COG0667@1|root,COG0667@2|Bacteria,1MVEH@1224|Proteobacteria,438SY@68525|delta/epsilon subdivisions,2X9D4@28221|Deltaproteobacteria,2YXPU@29|Myxococcales	28221|Deltaproteobacteria	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
HKD2_k127_9551256_2	1242864.D187_004046	1.199e-88	299.0	COG1633@1|root,COG1633@2|Bacteria	2|Bacteria	S	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)	-	-	1.14.19.11,1.14.19.2,1.14.19.26,1.16.3.1	ko:K03594,ko:K03921,ko:K07052	ko00061,ko00860,ko01040,ko01212,map00061,map00860,map01040,map01212	-	R00078,R03370,R08161,R11108,R11109	RC00917,RC02758	ko00000,ko00001,ko01000,ko01004	-	-	-	-
HKD2_k127_9554319_1	446470.Snas_5064	2.164e-20	96.0	COG0346@1|root,COG0346@2|Bacteria,2I8Q5@201174|Actinobacteria	201174|Actinobacteria	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	Aminoglyc_resit
HKD2_k127_9554319_0	1192034.CAP_0604	1.506e-24	105.0	COG0649@1|root,COG0649@2|Bacteria,1MVIN@1224|Proteobacteria,42M9G@68525|delta/epsilon subdivisions,2WIS7@28221|Deltaproteobacteria,2YU4Q@29|Myxococcales	28221|Deltaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0016020,GO:0044424,GO:0044464,GO:0071944	1.6.5.3	ko:K00333,ko:K13378	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa,Complex1_49kDa
HKD2_k127_9558684_6	1254432.SCE1572_46640	1.244e-37	143.0	COG0776@1|root,COG0776@2|Bacteria,1RH5Z@1224|Proteobacteria,42TK0@68525|delta/epsilon subdivisions,2WQ5D@28221|Deltaproteobacteria,2YVCZ@29|Myxococcales	28221|Deltaproteobacteria	K	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control	himA	-	-	ko:K04764	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
HKD2_k127_9558684_7	1254432.SCE1572_46635	3.748e-33	136.0	COG0789@1|root,COG0789@2|Bacteria,1RGYB@1224|Proteobacteria,42V1F@68525|delta/epsilon subdivisions,2WR79@28221|Deltaproteobacteria,2Z1R6@29|Myxococcales	28221|Deltaproteobacteria	K	helix_turn_helix, mercury resistance	-	-	-	-	-	-	-	-	-	-	-	-	MerR_1
HKD2_k127_9558684_1	1192034.CAP_1272	7.096e-186	610.0	2AIV6@1|root,319CD@2|Bacteria,1Q2BD@1224|Proteobacteria,437XV@68525|delta/epsilon subdivisions,2X37S@28221|Deltaproteobacteria,2YUR7@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9558684_0	448385.sce1649	1.046e-209	663.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2YX5F@29|Myxococcales	28221|Deltaproteobacteria	T	response regulator	nla19	-	-	ko:K07713	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD2_k127_9558684_8	448385.sce1650	1.086e-17	98.0	COG0745@1|root,COG0745@2|Bacteria,1P20B@1224|Proteobacteria,431TD@68525|delta/epsilon subdivisions,2WWZW@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
HKD2_k127_9558684_4	316067.Geob_3452	5.413e-92	315.0	COG0809@1|root,COG0809@2|Bacteria,1MUH3@1224|Proteobacteria,42MMG@68525|delta/epsilon subdivisions,2WJ9W@28221|Deltaproteobacteria,43SUY@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)	queA	GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016853,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0051075,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.4.99.17	ko:K07568	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Queuosine_synth
HKD2_k127_9558684_2	448385.sce1652	2.112e-156	505.0	COG0343@1|root,COG0343@2|Bacteria,1MUCA@1224|Proteobacteria,42M5Y@68525|delta/epsilon subdivisions,2WIMT@28221|Deltaproteobacteria,2YU84@29|Myxococcales	28221|Deltaproteobacteria	F	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)	tgt	-	2.4.2.29	ko:K00773	-	-	R03789,R10209	RC00063	ko00000,ko01000,ko03016	-	-	-	TGT
HKD2_k127_9558684_3	448385.sce1653	9.602e-152	494.0	COG0457@1|root,COG0745@1|root,COG0457@2|Bacteria,COG0745@2|Bacteria,1RATK@1224|Proteobacteria,42R5C@68525|delta/epsilon subdivisions,2WMZP@28221|Deltaproteobacteria,2YW9T@29|Myxococcales	28221|Deltaproteobacteria	T	Type II secretion system (T2SS), protein E, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,T2SSE_N,TPR_16,TPR_19,TPR_2,TPR_8
HKD2_k127_9558684_5	448385.sce1654	2.995e-38	161.0	COG3170@1|root,COG3170@2|Bacteria,1QX3V@1224|Proteobacteria,43BWB@68525|delta/epsilon subdivisions,2X773@28221|Deltaproteobacteria,2YVT2@29|Myxococcales	28221|Deltaproteobacteria	NU	zinc-ribbon domain	agmX	-	-	-	-	-	-	-	-	-	-	-	DUF4339,zinc_ribbon_4
HKD2_k127_9562727_0	448385.sce8590	3.561e-141	460.0	COG1505@1|root,COG1505@2|Bacteria,1NZ7N@1224|Proteobacteria,42NR5@68525|delta/epsilon subdivisions,2WMMK@28221|Deltaproteobacteria,2YU26@29|Myxococcales	28221|Deltaproteobacteria	E	Prolyl oligopeptidase, N-terminal beta-propeller domain	pep	-	3.4.21.26	ko:K01322	ko04614,map04614	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S9,Peptidase_S9_N
HKD2_k127_9562727_1	1379698.RBG1_1C00001G1640	2.205e-61	222.0	COG1028@1|root,COG1028@2|Bacteria,2NP4D@2323|unclassified Bacteria	2|Bacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HKD2_k127_9562727_2	1415754.JQMK01000002_gene2473	1.977e-41	158.0	COG0243@1|root,COG0243@2|Bacteria,1NR6J@1224|Proteobacteria,1RN6S@1236|Gammaproteobacteria,464HZ@72275|Alteromonadaceae	1236|Gammaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
HKD2_k127_9576432_0	671143.DAMO_0158	0.0001857	44.0	COG4409@1|root,COG4409@2|Bacteria,2NQRQ@2323|unclassified Bacteria	2|Bacteria	G	exo-alpha-(2->6)-sialidase activity	nanA	GO:0001573,GO:0003674,GO:0003824,GO:0004308,GO:0004553,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006629,GO:0006643,GO:0006664,GO:0006665,GO:0006672,GO:0006687,GO:0006689,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009311,GO:0009313,GO:0009987,GO:0016020,GO:0016042,GO:0016052,GO:0016787,GO:0016798,GO:0016997,GO:0019377,GO:0030149,GO:0034641,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043603,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044424,GO:0044464,GO:0046466,GO:0046479,GO:0046514,GO:0071704,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575,GO:1903509	3.2.1.18	ko:K01186	ko00511,ko00600,ko04142,map00511,map00600,map04142	-	R04018	RC00028,RC00077	ko00000,ko00001,ko01000,ko02042	-	GH33	-	BNR_2,Gram_pos_anchor,Sialidase,YSIRK_signal
HKD2_k127_95876_3	1033743.CAES01000078_gene3760	1.33e-09	70.0	COG1361@1|root,COG2866@1|root,COG3386@1|root,COG1361@2|Bacteria,COG2866@2|Bacteria,COG3386@2|Bacteria,1UNEH@1239|Firmicutes,4HPDD@91061|Bacilli	91061|Bacilli	E	S-layer homology domain	-	-	-	-	-	-	-	-	-	-	-	-	SLH
HKD2_k127_95876_1	502025.Hoch_3764	5.938e-51	199.0	COG0622@1|root,COG0622@2|Bacteria,1QY1A@1224|Proteobacteria,42ZTW@68525|delta/epsilon subdivisions,2WVJK@28221|Deltaproteobacteria,2Z1QE@29|Myxococcales	28221|Deltaproteobacteria	S	Phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
HKD2_k127_95876_0	391625.PPSIR1_18852	1.714e-62	223.0	COG0300@1|root,COG0300@2|Bacteria,1NUXK@1224|Proteobacteria	1224|Proteobacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HKD2_k127_9589154_1	448385.sce3638	1.601e-98	334.0	COG1520@1|root,COG1520@2|Bacteria,1Q3BK@1224|Proteobacteria,4392T@68525|delta/epsilon subdivisions,2X48J@28221|Deltaproteobacteria,2YYHQ@29|Myxococcales	28221|Deltaproteobacteria	S	PQQ-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2
HKD2_k127_9589154_2	1123256.KB907934_gene2365	1.073e-18	90.0	COG1848@1|root,COG1848@2|Bacteria	2|Bacteria	G	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	-	-	-	-	-	-	-	-	-	PIN
HKD2_k127_9589154_0	1192034.CAP_4111	1.512e-136	452.0	COG3104@1|root,COG3104@2|Bacteria,1MW6W@1224|Proteobacteria,42NNY@68525|delta/epsilon subdivisions,2WKK6@28221|Deltaproteobacteria,2YUFS@29|Myxococcales	28221|Deltaproteobacteria	P	POT family	-	-	-	ko:K03305	-	-	-	-	ko00000	2.A.17	-	-	PTR2
HKD2_k127_9599734_3	1254432.SCE1572_51180	7.135e-40	153.0	COG0557@1|root,COG0557@2|Bacteria,1MUS6@1224|Proteobacteria,42NGS@68525|delta/epsilon subdivisions,2WIWF@28221|Deltaproteobacteria,2YUMB@29|Myxococcales	28221|Deltaproteobacteria	J	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs	rnr	-	-	ko:K12573	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	OB_RNB,RNB,S1
HKD2_k127_9599734_2	290397.Adeh_0078	8.4e-42	164.0	2A9VF@1|root,30Z3B@2|Bacteria,1PKZS@1224|Proteobacteria,435JG@68525|delta/epsilon subdivisions,2WZXJ@28221|Deltaproteobacteria,2Z0YG@29|Myxococcales	290397.Adeh_0078|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9599734_0	1192034.CAP_5018	1.584e-101	340.0	COG0484@1|root,COG0484@2|Bacteria,1MUZ4@1224|Proteobacteria,42NBY@68525|delta/epsilon subdivisions,2WJV2@28221|Deltaproteobacteria,2YWFP@29|Myxococcales	28221|Deltaproteobacteria	O	DnaJ C terminal domain	-	-	-	ko:K03686,ko:K05516	-	-	-	-	ko00000,ko03029,ko03036,ko03110	-	-	-	DnaJ,DnaJ_C
HKD2_k127_9599734_1	1192034.CAP_3665	2.909e-69	248.0	COG2189@1|root,COG2189@2|Bacteria,1MX9M@1224|Proteobacteria	1224|Proteobacteria	L	Belongs to the N(4) N(6)-methyltransferase family	-	-	2.1.1.72	ko:K00571	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	Mrr_cat,N6_N4_Mtase
HKD2_k127_9599734_4	1192034.CAP_8872	3.386e-36	145.0	COG0840@1|root,COG0840@2|Bacteria,1RG2B@1224|Proteobacteria,42RYX@68525|delta/epsilon subdivisions,2WNHC@28221|Deltaproteobacteria,2YU4H@29|Myxococcales	28221|Deltaproteobacteria	NT	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer).	rppA	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	HAMP,MCPsignal
HKD2_k127_960145_1	3712.Bo6g119490.1	1.258e-20	96.0	COG0498@1|root,2QSQC@2759|Eukaryota,37KZW@33090|Viridiplantae,3GB3J@35493|Streptophyta,3HW1A@3699|Brassicales	35493|Streptophyta	E	threonine synthase	MTO2	GO:0003674,GO:0003824,GO:0004795,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008144,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0016829,GO:0016835,GO:0016838,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HKD2_k127_960145_0	502025.Hoch_6643	3.398e-68	246.0	COG1595@1|root,COG1595@2|Bacteria,1RKMN@1224|Proteobacteria,431Z5@68525|delta/epsilon subdivisions,2WWH8@28221|Deltaproteobacteria,2Z13Y@29|Myxococcales	28221|Deltaproteobacteria	K	RNA polymerase sigma factor	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD2_k127_960145_2	1192034.CAP_1747	4.184e-06	54.0	COG3170@1|root,COG3170@2|Bacteria,1QX3V@1224|Proteobacteria,43BWB@68525|delta/epsilon subdivisions,2X773@28221|Deltaproteobacteria,2YVT2@29|Myxococcales	28221|Deltaproteobacteria	NU	zinc-ribbon domain	-	-	-	-	-	-	-	-	-	-	-	-	zinc_ribbon_4
HKD2_k127_9607189_1	448385.sce4219	1.139e-26	118.0	COG1008@1|root,COG1008@2|Bacteria,1MV7V@1224|Proteobacteria,42NGD@68525|delta/epsilon subdivisions,2WJDC@28221|Deltaproteobacteria,2YTXZ@29|Myxococcales	28221|Deltaproteobacteria	C	Proton-conducting membrane transporter	nuoM	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q5_N,Proton_antipo_M
HKD2_k127_9607189_0	1192034.CAP_6528	6.394e-46	183.0	COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,42KZE@68525|delta/epsilon subdivisions,2WIPT@28221|Deltaproteobacteria,2YWE3@29|Myxococcales	28221|Deltaproteobacteria	CP	NADH-Ubiquinone oxidoreductase (complex I) chain 5 L domain protein	nuoL-1	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_C,Proton_antipo_M,Proton_antipo_N
HKD2_k127_9653045_1	1254432.SCE1572_45565	3.27e-81	280.0	COG0247@1|root,COG0247@2|Bacteria,1QA7J@1224|Proteobacteria,434VW@68525|delta/epsilon subdivisions,2X91N@28221|Deltaproteobacteria,2Z1GG@29|Myxococcales	28221|Deltaproteobacteria	C	Cysteine-rich domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG
HKD2_k127_9653045_3	1254432.SCE1572_32030	5.764e-49	187.0	COG0457@1|root,COG0457@2|Bacteria,1Q9KT@1224|Proteobacteria,43DTC@68525|delta/epsilon subdivisions,2WYTS@28221|Deltaproteobacteria,2Z0KP@29|Myxococcales	28221|Deltaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9653045_0	1192034.CAP_7190	8.221e-105	363.0	COG0515@1|root,COG0515@2|Bacteria,1Q35Q@1224|Proteobacteria,438W9@68525|delta/epsilon subdivisions,2X41T@28221|Deltaproteobacteria,2YXZI@29|Myxococcales	28221|Deltaproteobacteria	KLT	Protein kinase domain	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
HKD2_k127_9653045_2	448385.sce7929	8.894e-65	234.0	COG4191@1|root,COG4191@2|Bacteria,1MY5P@1224|Proteobacteria,42MTA@68525|delta/epsilon subdivisions,2WJ9Q@28221|Deltaproteobacteria,2YUZA@29|Myxococcales	28221|Deltaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	4HB_MCP_1,CHASE3,HAMP,HATPase_c,HisKA
HKD2_k127_9654358_2	243160.BMA2264	1.215e-81	284.0	COG1893@1|root,COG1893@2|Bacteria,1N0M5@1224|Proteobacteria,2VMSA@28216|Betaproteobacteria,1K55B@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid	-	-	1.1.1.169	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R02472	RC00726	ko00000,ko00001,ko00002,ko01000	-	-	-	ApbA,ApbA_C
HKD2_k127_9654358_11	391625.PPSIR1_41449	1.759e-20	101.0	COG4704@1|root,COG4704@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF2141
HKD2_k127_9654358_4	443143.GM18_3917	1.903e-65	250.0	COG0334@1|root,COG0334@2|Bacteria,1MUMF@1224|Proteobacteria,42NK7@68525|delta/epsilon subdivisions,2WKTV@28221|Deltaproteobacteria,43RYC@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain	-	-	1.4.1.3	ko:K00261	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
HKD2_k127_9654358_1	1223543.GP2_012_00830	1.154e-96	334.0	COG0458@1|root,COG0458@2|Bacteria,2HRFH@201174|Actinobacteria,4GCFV@85026|Gordoniaceae	201174|Actinobacteria	EF	ATP-grasp domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9654358_6	1254432.SCE1572_09595	3.342e-56	206.0	COG2267@1|root,COG2267@2|Bacteria,1REM6@1224|Proteobacteria,42VM4@68525|delta/epsilon subdivisions,2WRYC@28221|Deltaproteobacteria,2Z398@29|Myxococcales	28221|Deltaproteobacteria	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
HKD2_k127_9654358_8	1157943.KB892706_gene4160	4.83e-46	174.0	COG2114@1|root,COG2114@2|Bacteria,2IE0W@201174|Actinobacteria,236AM@1762|Mycobacteriaceae	201174|Actinobacteria	T	Adenylate guanylate cyclase	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc,YHS
HKD2_k127_9654358_7	557599.MKAN_18905	8.542e-52	190.0	COG5418@1|root,COG5418@2|Bacteria,2H2GT@201174|Actinobacteria,23CAT@1762|Mycobacteriaceae	201174|Actinobacteria	S	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9654358_9	1288079.AUKN01000013_gene1619	1.781e-37	149.0	COG0406@1|root,COG0406@2|Bacteria,2GN7B@201174|Actinobacteria	201174|Actinobacteria	G	Belongs to the phosphoglycerate mutase family	-	-	-	-	-	-	-	-	-	-	-	-	His_Phos_1
HKD2_k127_9654358_0	118166.JH976538_gene4978	4.558e-121	404.0	COG5279@1|root,COG5279@2|Bacteria,1G2DZ@1117|Cyanobacteria,1HA0U@1150|Oscillatoriales	1117|Cyanobacteria	D	Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Transglut_core
HKD2_k127_9654358_12	1169152.AXVD01000019_gene786	3.066e-06	60.0	COG0510@1|root,COG0510@2|Bacteria,2GNR3@201174|Actinobacteria,4G62Q@85025|Nocardiaceae	201174|Actinobacteria	M	Phosphotransferase enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	APH
HKD2_k127_9654358_10	345341.KUTG_06982	1.459e-31	133.0	COG5587@1|root,COG5587@2|Bacteria,2IJG5@201174|Actinobacteria,4E0G4@85010|Pseudonocardiales	201174|Actinobacteria	S	Conserved hypothetical protein (DUF2461)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2461
HKD2_k127_9654358_3	1192034.CAP_0774	1.098e-73	269.0	COG0515@1|root,COG0515@2|Bacteria	1192034.CAP_0774|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9663930_14	164757.Mjls_4728	1.716e-06	60.0	COG0515@1|root,COG3055@1|root,COG0515@2|Bacteria,COG3055@2|Bacteria,2I4I0@201174|Actinobacteria,23F8F@1762|Mycobacteriaceae	201174|Actinobacteria	KLT	PFAM Protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	Kelch_1,Pkinase
HKD2_k127_9663930_0	1038860.AXAP01000023_gene7432	4.418e-199	649.0	COG2072@1|root,COG2072@2|Bacteria,1MU71@1224|Proteobacteria,2TV2E@28211|Alphaproteobacteria,3JQVH@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	MA20_07830	-	-	-	-	-	-	-	-	-	-	-	FMO-like,NAD_binding_8
HKD2_k127_9663930_13	1278073.MYSTI_05714	1.225e-06	62.0	COG3055@1|root,COG3055@2|Bacteria	2|Bacteria	G	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses	-	-	-	-	-	-	-	-	-	-	-	-	Big_5,DUF3494,Kelch_1,Kelch_6,Laminin_G_3
HKD2_k127_9663930_10	994573.T472_0214875	8.104e-20	104.0	COG0705@1|root,COG0705@2|Bacteria,1TQXT@1239|Firmicutes,247PT@186801|Clostridia,36H7U@31979|Clostridiaceae	186801|Clostridia	S	Rhomboid family	gluP	-	3.4.21.105	ko:K19225	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Rhomboid
HKD2_k127_9663930_3	448385.sce1062	7.251e-66	233.0	COG0703@1|root,COG3620@1|root,COG0703@2|Bacteria,COG3620@2|Bacteria,1QA4J@1224|Proteobacteria,42XE0@68525|delta/epsilon subdivisions	1224|Proteobacteria	F	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate	aroK	-	2.7.1.71	ko:K00891,ko:K15546	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko03000	-	-	-	SKI
HKD2_k127_9663930_9	1192034.CAP_8095	2.448e-23	112.0	COG2755@1|root,COG2755@2|Bacteria	2|Bacteria	E	lipolytic protein G-D-S-L family	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
HKD2_k127_9663930_12	485913.Krac_4700	1.314e-10	73.0	2DRZ7@1|root,33DSV@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9663930_7	520709.F985_02059	7.724e-41	156.0	2CFUA@1|root,32S2G@2|Bacteria,1N66W@1224|Proteobacteria,1SA2Y@1236|Gammaproteobacteria,3NKYZ@468|Moraxellaceae	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9663930_6	1408444.JHYC01000037_gene1889	3.812e-41	170.0	COG2706@1|root,COG2706@2|Bacteria,1RB38@1224|Proteobacteria,1SNAF@1236|Gammaproteobacteria,1JE2M@118969|Legionellales	118969|Legionellales	G	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9663930_15	927658.AJUM01000042_gene1722	0.0005654	52.0	COG2353@1|root,COG2911@1|root,COG3210@1|root,COG2353@2|Bacteria,COG2911@2|Bacteria,COG3210@2|Bacteria,4PMJQ@976|Bacteroidetes,2G0DU@200643|Bacteroidia,3XM24@558415|Marinilabiliaceae	976|Bacteroidetes	U	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9663930_5	1192034.CAP_8784	1.595e-47	179.0	COG0170@1|root,COG0170@2|Bacteria,1NAJ2@1224|Proteobacteria,42XJ5@68525|delta/epsilon subdivisions,2WSX5@28221|Deltaproteobacteria,2YVZW@29|Myxococcales	28221|Deltaproteobacteria	I	Dolichol kinase	-	-	-	-	-	-	-	-	-	-	-	-	CTP_transf_1
HKD2_k127_9663930_1	1254432.SCE1572_21885	5.588e-191	614.0	COG1012@1|root,COG1012@2|Bacteria,1MWD4@1224|Proteobacteria,439ZZ@68525|delta/epsilon subdivisions,2X4EZ@28221|Deltaproteobacteria,2YYW8@29|Myxococcales	28221|Deltaproteobacteria	C	Aldehyde dehydrogenase family	-	-	1.2.1.77,1.2.1.91,3.3.2.12	ko:K02618,ko:K15514	ko00360,ko00362,ko01120,map00360,map00362,map01120	-	R09554,R09820,R09836	RC00080,RC02667	ko00000,ko00001,ko01000	-	-	-	Aldedh
HKD2_k127_9663930_11	448385.sce6967	7.055e-12	71.0	COG2204@1|root,COG2204@2|Bacteria,1NABF@1224|Proteobacteria,43C0I@68525|delta/epsilon subdivisions,2X7B5@28221|Deltaproteobacteria,2Z3KD@29|Myxococcales	28221|Deltaproteobacteria	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
HKD2_k127_9663930_4	1121920.AUAU01000006_gene371	5.006e-50	186.0	COG3945@1|root,COG3945@2|Bacteria	2|Bacteria	P	hemerythrin HHE cation binding domain	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Hemerythrin
HKD2_k127_9663930_8	404589.Anae109_1645	1.017e-24	112.0	COG3427@1|root,COG3427@2|Bacteria,1PB5Q@1224|Proteobacteria	1224|Proteobacteria	S	Polyketide cyclase / dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
HKD2_k127_9663930_2	525368.HMPREF0591_2162	4.493e-97	321.0	COG0596@1|root,COG0596@2|Bacteria,2GKJB@201174|Actinobacteria,23F6M@1762|Mycobacteriaceae	201174|Actinobacteria	S	Catalyzes hydrolytic cleavage of carbon-halogen bonds in halogenated aliphatic compounds, leading to the formation of the corresponding primary alcohols, halide ions and protons	dhmA	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	3.8.1.5	ko:K01563	ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120	-	R05284,R05367,R05368,R05369,R05370,R07669,R07670	RC01317,RC01340,RC01341,RC02013	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1
HKD2_k127_9673325_0	1254432.SCE1572_36085	2.158e-181	585.0	COG1413@1|root,COG1413@2|Bacteria,1Q38Z@1224|Proteobacteria,43903@68525|delta/epsilon subdivisions,2X455@28221|Deltaproteobacteria,2YYA6@29|Myxococcales	28221|Deltaproteobacteria	C	HEAT repeats	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2
HKD2_k127_9673325_2	1207063.P24_03740	5.766e-81	278.0	COG0625@1|root,COG0625@2|Bacteria,1MUN3@1224|Proteobacteria,2TTVR@28211|Alphaproteobacteria,2JPS1@204441|Rhodospirillales	204441|Rhodospirillales	O	Belongs to the GST superfamily	-	-	-	ko:K11209	-	-	-	-	ko00000,ko01000	-	-	-	GST_C,GST_N
HKD2_k127_9673325_1	1192034.CAP_7201	2.852e-102	342.0	COG1183@1|root,COG1183@2|Bacteria,1MWD9@1224|Proteobacteria,42QV4@68525|delta/epsilon subdivisions,2WMR6@28221|Deltaproteobacteria,2YVVU@29|Myxococcales	28221|Deltaproteobacteria	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pssA	-	2.7.8.8	ko:K17103	ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110	M00093	R01800	RC00002,RC00017,RC02795	ko00000,ko00001,ko00002,ko01000	-	-	-	CDP-OH_P_transf
HKD2_k127_9673325_4	316067.Geob_1555	1.057e-18	96.0	COG1729@1|root,COG1729@2|Bacteria,1MUSV@1224|Proteobacteria,42T19@68525|delta/epsilon subdivisions,2WQ0M@28221|Deltaproteobacteria,43UV0@69541|Desulfuromonadales	28221|Deltaproteobacteria	D	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_6
HKD2_k127_9673325_3	448385.sce0299	1.387e-19	103.0	COG1652@1|root,COG1652@2|Bacteria,1MUBV@1224|Proteobacteria,42QS9@68525|delta/epsilon subdivisions,2WN3H@28221|Deltaproteobacteria,2YVFR@29|Myxococcales	28221|Deltaproteobacteria	S	LysM domain	-	-	-	-	-	-	-	-	-	-	-	-	LysM
HKD2_k127_9706018_1	1254432.SCE1572_27280	9.149e-34	133.0	COG1974@1|root,COG1974@2|Bacteria,1MW80@1224|Proteobacteria,42SP5@68525|delta/epsilon subdivisions,2WP39@28221|Deltaproteobacteria,2YUQU@29|Myxococcales	28221|Deltaproteobacteria	K	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair	lexA	GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032991,GO:0032993,GO:0043565,GO:0044212,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001141	3.4.21.88	ko:K01356	-	M00729	-	-	ko00000,ko00002,ko01000,ko01002,ko03400	-	-	-	LexA_DNA_bind,Peptidase_S24
HKD2_k127_9706018_0	448385.sce4318	5.936e-69	238.0	COG0664@1|root,COG0664@2|Bacteria,1NBX3@1224|Proteobacteria,42UGQ@68525|delta/epsilon subdivisions,2WQY8@28221|Deltaproteobacteria,2YVI9@29|Myxococcales	28221|Deltaproteobacteria	T	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
HKD2_k127_9712388_4	448385.sce8438	1.267e-27	113.0	COG0484@1|root,COG0484@2|Bacteria	2|Bacteria	O	heat shock protein binding	dnaJ	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
HKD2_k127_9712388_0	1254432.SCE1572_12420	6.13e-90	301.0	COG0607@1|root,COG3118@1|root,COG0607@2|Bacteria,COG3118@2|Bacteria	2|Bacteria	O	belongs to the thioredoxin family	-	-	2.8.1.7,4.4.1.16	ko:K03671,ko:K05838,ko:K07390,ko:K11717	ko00450,ko01100,ko04621,ko05418,map00450,map01100,map04621,map05418	-	R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000,ko03029,ko03110	-	-	-	Aminotran_5,Rhodanese,TPR_19,TPR_20,Thioredoxin
HKD2_k127_9712388_1	448385.sce0007	5.688e-60	211.0	COG0735@1|root,COG0735@2|Bacteria,1RDWJ@1224|Proteobacteria,42MN8@68525|delta/epsilon subdivisions,2WQKR@28221|Deltaproteobacteria,2YVE5@29|Myxococcales	28221|Deltaproteobacteria	K	Belongs to the Fur family	fur	-	-	ko:K03711	-	-	-	-	ko00000,ko03000	-	-	-	FUR
HKD2_k127_9712388_5	84531.JMTZ01000030_gene211	1.88e-11	77.0	COG1572@1|root,COG1572@2|Bacteria,1QVRG@1224|Proteobacteria,1T2HZ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Domain of unknown function (DUF5122) beta-propeller	-	-	-	-	-	-	-	-	-	-	-	-	DUF5122
HKD2_k127_9712388_3	1254432.SCE1572_40985	2.615e-47	183.0	COG0212@1|root,COG0212@2|Bacteria,1MZG0@1224|Proteobacteria,42U47@68525|delta/epsilon subdivisions,2WQXE@28221|Deltaproteobacteria,2YVV5@29|Myxococcales	28221|Deltaproteobacteria	H	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family	-	-	6.3.3.2	ko:K01934	ko00670,ko01100,map00670,map01100	-	R02301	RC00183	ko00000,ko00001,ko01000	-	-	-	5-FTHF_cyc-lig
HKD2_k127_9712388_2	264732.Moth_1737	2.118e-49	180.0	COG0338@1|root,COG0338@2|Bacteria,1TRDX@1239|Firmicutes,25E75@186801|Clostridia,42G63@68295|Thermoanaerobacterales	186801|Clostridia	H	PFAM D12 class N6 adenine-specific DNA methyltransferase	dam	-	2.1.1.72	ko:K06223	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko02048,ko03032,ko03400	-	-	-	MethyltransfD12
HKD2_k127_9738734_2	1254432.SCE1572_00060	2.586e-61	237.0	COG1807@1|root,COG1807@2|Bacteria,1NMIZ@1224|Proteobacteria,42RXF@68525|delta/epsilon subdivisions,2WNF1@28221|Deltaproteobacteria,2YV5A@29|Myxococcales	28221|Deltaproteobacteria	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	arnT	-	-	-	-	-	-	-	-	-	-	-	PMT,PMT_2
HKD2_k127_9738734_1	1254432.SCE1572_02145	1.17e-77	269.0	COG1024@1|root,COG1024@2|Bacteria,1MWZC@1224|Proteobacteria,42QPM@68525|delta/epsilon subdivisions,2WMRG@28221|Deltaproteobacteria,2YWMX@29|Myxococcales	28221|Deltaproteobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	4.2.1.17	ko:K01715	ko00650,ko01200,map00650,map01200	-	R03026	RC00831	ko00000,ko00001,ko01000	-	-	iAF987.Gmet_1716	ECH_1
HKD2_k127_9738734_0	391625.PPSIR1_10405	9.88e-109	372.0	COG1250@1|root,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,42M6J@68525|delta/epsilon subdivisions,2WJZQ@28221|Deltaproteobacteria,2YWS8@29|Myxococcales	28221|Deltaproteobacteria	I	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain	mmgB	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
HKD2_k127_9738734_4	639030.JHVA01000001_gene3241	1.826e-06	60.0	COG0457@1|root,COG0457@2|Bacteria,3Y6J0@57723|Acidobacteria,2JKHK@204432|Acidobacteriia	204432|Acidobacteriia	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_11,TPR_16,TPR_19,TPR_2,TPR_6,TPR_8
HKD2_k127_9784385_0	1192034.CAP_0155	7.772e-89	315.0	COG0810@1|root,COG0810@2|Bacteria,1QGPT@1224|Proteobacteria,434QY@68525|delta/epsilon subdivisions,2WZ24@28221|Deltaproteobacteria,2Z15Z@29|Myxococcales	28221|Deltaproteobacteria	M	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9784385_5	1192034.CAP_2871	3.116e-15	85.0	COG0526@1|root,COG0526@2|Bacteria,1PYQJ@1224|Proteobacteria,435HK@68525|delta/epsilon subdivisions,2WZV8@28221|Deltaproteobacteria,2Z2TQ@29|Myxococcales	28221|Deltaproteobacteria	CO	COG0526, thiol-disulfide isomerase and thioredoxins	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9784385_2	1254432.SCE1572_42165	2.164e-39	162.0	COG1225@1|root,COG1225@2|Bacteria,1R0DK@1224|Proteobacteria,43CW6@68525|delta/epsilon subdivisions,2X846@28221|Deltaproteobacteria,2Z1BG@29|Myxococcales	28221|Deltaproteobacteria	O	Thioredoxin-like	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
HKD2_k127_9784385_1	448385.sce7235	1.821e-68	258.0	COG1947@1|root,COG1947@2|Bacteria,1Q9QD@1224|Proteobacteria,434IQ@68525|delta/epsilon subdivisions,2WYVY@28221|Deltaproteobacteria,2Z0RW@29|Myxococcales	28221|Deltaproteobacteria	I	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9784385_3	215803.DB30_5798	1.939e-30	134.0	COG1633@1|root,COG1633@2|Bacteria,1P131@1224|Proteobacteria,439DQ@68525|delta/epsilon subdivisions,2X4NM@28221|Deltaproteobacteria,2YZB1@29|Myxococcales	28221|Deltaproteobacteria	S	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9789252_3	290397.Adeh_1859	1.016e-11	68.0	COG3024@1|root,COG3024@2|Bacteria,1NGJ8@1224|Proteobacteria,42XRW@68525|delta/epsilon subdivisions,2X2JD@28221|Deltaproteobacteria,2YW45@29|Myxococcales	28221|Deltaproteobacteria	S	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase	yacG	-	-	ko:K09862	-	-	-	-	ko00000	-	-	-	YacG
HKD2_k127_9789252_0	1254432.SCE1572_10545	1.985e-66	241.0	COG2339@1|root,COG2339@2|Bacteria,1PCW8@1224|Proteobacteria,4343U@68525|delta/epsilon subdivisions,2X52Q@28221|Deltaproteobacteria,2Z013@29|Myxococcales	28221|Deltaproteobacteria	S	Protease prsW family	-	-	-	-	-	-	-	-	-	-	-	-	PrsW-protease
HKD2_k127_9789252_1	1254432.SCE1572_35365	1.225e-44	177.0	COG0810@1|root,COG0810@2|Bacteria,1R65W@1224|Proteobacteria,42XJ0@68525|delta/epsilon subdivisions,2WT3A@28221|Deltaproteobacteria,2YYW2@29|Myxococcales	28221|Deltaproteobacteria	M	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins	-	-	-	-	-	-	-	-	-	-	-	-	TonB_C
HKD2_k127_9799249_2	1123073.KB899242_gene1356	3.51e-05	56.0	2DNAS@1|root,32WH6@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9799249_1	448385.sce6041	2.074e-05	47.0	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,42M2A@68525|delta/epsilon subdivisions,2WIJY@28221|Deltaproteobacteria,2YUEB@29|Myxococcales	28221|Deltaproteobacteria	S	ATPase components of ABC transporters with duplicated ATPase domains	-	-	-	ko:K06158	-	-	-	-	ko00000,ko03012	-	-	-	ABC_tran,ABC_tran_Xtn
HKD2_k127_9807328_6	1521187.JPIM01000112_gene2332	8.498e-22	99.0	COG0286@1|root,COG2852@1|root,COG0286@2|Bacteria,COG2852@2|Bacteria,2G859@200795|Chloroflexi,377GB@32061|Chloroflexia	32061|Chloroflexia	L	N-6 DNA Methylase	-	-	-	-	-	-	-	-	-	-	-	-	N6_Mtase
HKD2_k127_9807328_7	335659.S23_41210	1.193e-16	83.0	29TWJ@1|root,30F5A@2|Bacteria,1NA65@1224|Proteobacteria,2UMBB@28211|Alphaproteobacteria,3K1XF@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9807328_1	448385.sce5852	1.281e-141	465.0	COG0484@1|root,COG0484@2|Bacteria,1MVMS@1224|Proteobacteria,42KZM@68525|delta/epsilon subdivisions,2WJGP@28221|Deltaproteobacteria,2YXG3@29|Myxococcales	28221|Deltaproteobacteria	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
HKD2_k127_9807328_2	1192034.CAP_5362	4.43e-75	259.0	COG0546@1|root,COG0546@2|Bacteria,1P19B@1224|Proteobacteria,431NT@68525|delta/epsilon subdivisions,2WWU8@28221|Deltaproteobacteria,2YVRG@29|Myxococcales	28221|Deltaproteobacteria	S	phosphoglycolate phosphatase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9807328_4	637390.AFOH01000136_gene1793	3.984e-55	203.0	COG2085@1|root,COG2085@2|Bacteria,1NI54@1224|Proteobacteria,1S2JM@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	NADPH-dependent F420 reductase	-	-	1.5.1.40	ko:K06988	-	-	-	-	ko00000,ko01000	-	-	-	F420_oxidored
HKD2_k127_9807328_3	1254432.SCE1572_15340	2.343e-66	254.0	COG1262@1|root,COG1262@2|Bacteria	2|Bacteria	T	PFAM Formylglycine-generating sulfatase enzyme	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase,HdeA
HKD2_k127_9807328_0	502025.Hoch_2510	4.075e-174	557.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2YU4Y@29|Myxococcales	28221|Deltaproteobacteria	T	Two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	ko:K07712	ko02020,map02020	M00497	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD2_k127_9830373_0	448385.sce6592	1.249e-319	1065.0	COG0457@1|root,COG0457@2|Bacteria,1PC8F@1224|Proteobacteria,438AR@68525|delta/epsilon subdivisions,2X3K3@28221|Deltaproteobacteria,2YWDI@29|Myxococcales	28221|Deltaproteobacteria	S	Tetratricopeptide repeats	-	-	-	-	-	-	-	-	-	-	-	-	TPR_19
HKD2_k127_9830373_1	1254432.SCE1572_03290	7.752e-157	498.0	COG0752@1|root,COG0752@2|Bacteria,1MVCJ@1224|Proteobacteria,42MNQ@68525|delta/epsilon subdivisions,2WJJW@28221|Deltaproteobacteria,2YTSG@29|Myxococcales	28221|Deltaproteobacteria	J	glycyl-tRNA synthetase alpha subunit	glyQ	-	6.1.1.14	ko:K01878	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iAF987.Gmet_2942	tRNA-synt_2e
HKD2_k127_9830373_3	1254432.SCE1572_40735	3.194e-66	233.0	COG0457@1|root,COG0457@2|Bacteria	1254432.SCE1572_40735|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9830373_2	517418.Ctha_0233	9.11e-81	283.0	COG4232@1|root,COG4233@1|root,COG4232@2|Bacteria,COG4233@2|Bacteria,1FDRS@1090|Chlorobi	1090|Chlorobi	C	Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps	dsbD	-	1.8.1.8	ko:K04084	-	-	-	-	ko00000,ko01000,ko03110	5.A.1.1	-	-	DsbC,DsbD,Thioredoxin_7
HKD2_k127_9841802_0	290397.Adeh_0078	1.459e-38	153.0	2A9VF@1|root,30Z3B@2|Bacteria,1PKZS@1224|Proteobacteria,435JG@68525|delta/epsilon subdivisions,2WZXJ@28221|Deltaproteobacteria,2Z0YG@29|Myxococcales	290397.Adeh_0078|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9855192_0	1192034.CAP_5617	4.693e-117	379.0	COG0820@1|root,COG0820@2|Bacteria,1MUYK@1224|Proteobacteria,42N69@68525|delta/epsilon subdivisions,2WIUJ@28221|Deltaproteobacteria,2YURZ@29|Myxococcales	28221|Deltaproteobacteria	J	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs	rlmN	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140101,GO:0140102,GO:1901360	2.1.1.192	ko:K06941	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Fer4_14,Radical_SAM
HKD2_k127_9855192_1	1192034.CAP_7539	2.971e-61	231.0	COG0682@1|root,COG0682@2|Bacteria,1Q2R4@1224|Proteobacteria,438CQ@68525|delta/epsilon subdivisions,2WP0G@28221|Deltaproteobacteria,2YWK4@29|Myxococcales	28221|Deltaproteobacteria	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	lgt	-	-	ko:K13292	-	-	-	-	ko00000,ko01000	-	-	-	LGT
HKD2_k127_9855192_2	1173021.ALWA01000016_gene2147	4.102e-48	192.0	COG2890@1|root,COG2890@2|Bacteria,1GQW3@1117|Cyanobacteria	1117|Cyanobacteria	J	Thiopurine S-methyltransferase (TPMT)	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25,TPMT
HKD2_k127_9855192_3	1382303.JPOM01000001_gene2544	4.36e-42	160.0	COG3391@1|root,COG3391@2|Bacteria,1R6BZ@1224|Proteobacteria,2U2WX@28211|Alphaproteobacteria,2KG1G@204458|Caulobacterales	204458|Caulobacterales	S	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9864458_0	1254432.SCE1572_10990	2.006e-124	405.0	COG1716@1|root,COG2199@1|root,COG1716@2|Bacteria,COG3706@2|Bacteria,1MZV7@1224|Proteobacteria,4302C@68525|delta/epsilon subdivisions,2WVBW@28221|Deltaproteobacteria,2YUSZ@29|Myxococcales	28221|Deltaproteobacteria	T	GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	FHA,GGDEF,Yop-YscD_cpl
HKD2_k127_9864458_2	448385.sce1851	1.339e-78	280.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,42MVV@68525|delta/epsilon subdivisions,2X4JB@28221|Deltaproteobacteria,2YZ4I@29|Myxococcales	28221|Deltaproteobacteria	KLT	Family membership	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HKD2_k127_9864458_3	1254432.SCE1572_38770	1.622e-39	157.0	COG4886@1|root,COG4886@2|Bacteria,1R9FD@1224|Proteobacteria,435HC@68525|delta/epsilon subdivisions,2X99T@28221|Deltaproteobacteria,2Z2T4@29|Myxococcales	28221|Deltaproteobacteria	S	Leucine-rich repeat (LRR) protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9864458_1	1254432.SCE1572_40325	1.942e-107	383.0	COG0457@1|root,COG3903@1|root,COG0457@2|Bacteria,COG3903@2|Bacteria,1MWPD@1224|Proteobacteria,438M3@68525|delta/epsilon subdivisions,2X1ZS@28221|Deltaproteobacteria,2YX8A@29|Myxococcales	28221|Deltaproteobacteria	T	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_22,Guanylate_cyc,TPR_12
HKD2_k127_9884202_4	517417.Cpar_0379	0.0001385	54.0	28IAZ@1|root,2Z8DG@2|Bacteria	2|Bacteria	S	DGQHR domain	-	-	-	-	-	-	-	-	-	-	-	-	DndB
HKD2_k127_9884202_3	1449347.JQLN01000001_gene163	7.621e-49	193.0	COG3511@1|root,COG5563@1|root,COG3511@2|Bacteria,COG5563@2|Bacteria,2GKPN@201174|Actinobacteria	201174|Actinobacteria	M	phospholipase C	-	-	3.1.4.3	ko:K01114	ko00562,ko00564,ko00565,ko01100,ko01110,ko02024,ko04919,map00562,map00564,map00565,map01100,map01110,map02024,map04919	-	R01312,R02027,R02052,R03332,R07381	RC00017,RC00425	ko00000,ko00001,ko01000,ko02042	-	-	-	Phosphoesterase
HKD2_k127_9884202_0	1278073.MYSTI_00197	7.366e-106	366.0	COG0784@1|root,COG2203@1|root,COG4191@1|root,COG0784@2|Bacteria,COG2203@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42PZ5@68525|delta/epsilon subdivisions,2WKB1@28221|Deltaproteobacteria,2Z2WE@29|Myxococcales	28221|Deltaproteobacteria	T	PAS fold	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HATPase_c,HisKA,PAS,PAS_3,PAS_4,Response_reg
HKD2_k127_9884202_2	391625.PPSIR1_22069	2.295e-54	206.0	COG0789@1|root,COG0789@2|Bacteria,1N1YK@1224|Proteobacteria	1224|Proteobacteria	K	Regulatory protein, MerR	-	-	-	-	-	-	-	-	-	-	-	-	MerR_1
HKD2_k127_9884202_1	1415779.JOMH01000001_gene2297	7.311e-69	236.0	COG3239@1|root,COG3239@2|Bacteria,1QKDT@1224|Proteobacteria,1RQCX@1236|Gammaproteobacteria,1X49C@135614|Xanthomonadales	135614|Xanthomonadales	I	desaturase	-	-	-	-	-	-	-	-	-	-	-	-	FA_desaturase
HKD2_k127_9897696_2	903814.ELI_1710	1.544e-25	106.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1TPK8@1239|Firmicutes,247RW@186801|Clostridia,25VEG@186806|Eubacteriaceae	186801|Clostridia	G	Belongs to the PEP-utilizing enzyme family	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
HKD2_k127_9897696_0	1232453.BAIF02000135_gene1598	4.142e-84	293.0	COG2801@1|root,COG2801@2|Bacteria	2|Bacteria	L	transposition	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_28,HTH_32,LZ_Tnp_IS481,rve,rve_3
HKD2_k127_9897696_3	663610.JQKO01000007_gene2310	4.976e-16	89.0	COG0236@1|root,COG0236@2|Bacteria,1NHIC@1224|Proteobacteria,2UFUJ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	IQ	Phosphopantetheine attachment site	-	-	-	-	-	-	-	-	-	-	-	-	PP-binding
HKD2_k127_9897696_1	1254432.SCE1572_36840	1.153e-72	251.0	COG0508@1|root,COG0508@2|Bacteria,1MUGY@1224|Proteobacteria,42PEC@68525|delta/epsilon subdivisions,2X5JG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex	-	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
HKD2_k127_9909142_2	448385.sce2072	5.671e-27	123.0	COG5164@1|root,COG5164@2|Bacteria,1R0C5@1224|Proteobacteria,43CUH@68525|delta/epsilon subdivisions,2X826@28221|Deltaproteobacteria,2Z24H@29|Myxococcales	28221|Deltaproteobacteria	K	regulation of DNA-templated transcription, elongation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9909142_1	1254432.SCE1572_35390	4.7e-37	153.0	29RMJ@1|root,30CQT@2|Bacteria,1QTPA@1224|Proteobacteria,4380Z@68525|delta/epsilon subdivisions,2X3B0@28221|Deltaproteobacteria,2YV6U@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9909142_0	448385.sce9087	1.15e-134	445.0	COG1413@1|root,COG1413@2|Bacteria	2|Bacteria	C	deoxyhypusine monooxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,HEAT_PBS,NB-ARC,cNMP_binding
HKD2_k127_9917448_0	404589.Anae109_0939	4.207e-142	475.0	COG1793@1|root,COG3285@1|root,COG1793@2|Bacteria,COG3285@2|Bacteria,1MVWY@1224|Proteobacteria,42U99@68525|delta/epsilon subdivisions,2WQ5W@28221|Deltaproteobacteria,2YWMR@29|Myxococcales	28221|Deltaproteobacteria	L	ATP dependent DNA ligase domain protein	-	-	6.5.1.1	ko:K01971	ko03450,map03450	-	R00381	RC00005	ko00000,ko00001,ko01000,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,LigD_N
HKD2_k127_9917448_1	1123073.KB899242_gene947	1.312e-39	151.0	COG1273@1|root,COG1273@2|Bacteria,1N4UX@1224|Proteobacteria,1RNJ7@1236|Gammaproteobacteria,1X3MS@135614|Xanthomonadales	135614|Xanthomonadales	L	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD	ku	-	-	ko:K10979	ko03450,map03450	-	-	-	ko00000,ko00001,ko03400	-	-	-	Ku
HKD2_k127_9933478_0	1192034.CAP_1789	4.131e-197	628.0	COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,42N87@68525|delta/epsilon subdivisions,2WK1B@28221|Deltaproteobacteria,2YYJM@29|Myxococcales	28221|Deltaproteobacteria	S	ABC1 family	-	-	-	ko:K03688	-	-	-	-	ko00000	-	-	-	ABC1,APH,WaaY
HKD2_k127_9933478_2	1254432.SCE1572_45815	1.109e-104	372.0	COG1376@1|root,COG1376@2|Bacteria,1NKBB@1224|Proteobacteria,432T9@68525|delta/epsilon subdivisions,2WYN9@28221|Deltaproteobacteria,2YWNH@29|Myxococcales	28221|Deltaproteobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	YkuD
HKD2_k127_9933478_1	1192034.CAP_1843	4.673e-128	421.0	COG0642@1|root,COG2203@1|root,COG2203@2|Bacteria,COG2205@2|Bacteria,1R91W@1224|Proteobacteria,42PXP@68525|delta/epsilon subdivisions,2WJJX@28221|Deltaproteobacteria,2YX85@29|Myxococcales	28221|Deltaproteobacteria	T	GAF domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HATPase_c,HisKA,PAS,PAS_9
HKD2_k127_9934331_2	1242864.D187_009943	9.544e-46	181.0	COG4635@1|root,COG4635@2|Bacteria	2|Bacteria	CH	menaquinone-dependent protoporphyrinogen oxidase activity	-	-	1.3.5.3	ko:K00230	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R09489	RC00885	ko00000,ko00001,ko00002,ko01000	-	-	-	Flavodoxin_5
HKD2_k127_9934331_3	319003.Bra1253DRAFT_08200	4.635e-21	108.0	2C4KB@1|root,32YM4@2|Bacteria,1N74A@1224|Proteobacteria,2UHJ4@28211|Alphaproteobacteria,3JZRB@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9934331_5	1134445.AJJM01000039_gene1284	3.041e-12	78.0	COG0583@1|root,COG0583@2|Bacteria,2GMES@201174|Actinobacteria	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HKD2_k127_9934331_4	402777.KB235904_gene3312	2.231e-16	85.0	COG1051@1|root,COG1051@2|Bacteria,1G5JN@1117|Cyanobacteria,1HAUG@1150|Oscillatoriales	1117|Cyanobacteria	F	NUDIX domain	-	-	-	ko:K12152	-	-	-	-	ko00000,ko01000	-	-	-	NUDIX
HKD2_k127_9934331_1	1232410.KI421412_gene357	7.936e-103	343.0	COG0604@1|root,COG0604@2|Bacteria,1MWBD@1224|Proteobacteria,42PQH@68525|delta/epsilon subdivisions,2WM5W@28221|Deltaproteobacteria,43TDI@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Zinc-binding dehydrogenase	-	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N,ADH_zinc_N_2
HKD2_k127_9934331_0	1192034.CAP_8058	1.944e-272	850.0	COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,42MUH@68525|delta/epsilon subdivisions,2WJ16@28221|Deltaproteobacteria,2YU4C@29|Myxococcales	28221|Deltaproteobacteria	C	acyl-CoA dehydrogenase	-	-	-	ko:K09456,ko:K20035	ko00920,map00920	-	R11130	RC03363	ko00000,ko00001,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N
HKD2_k127_9934331_7	1242864.D187_007812	4.166e-07	57.0	2EV1C@1|root,33NGG@2|Bacteria,1NKKY@1224|Proteobacteria,42X6Y@68525|delta/epsilon subdivisions,2WTH7@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9934331_8	1071073.KI530537_gene1646	0.0001992	50.0	COG2805@1|root,COG2805@2|Bacteria,1TQ5F@1239|Firmicutes,4H9RK@91061|Bacilli,1ZB6M@1386|Bacillus	91061|Bacilli	NU	twitching motility protein	pilT	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
HKD2_k127_9965260_0	1254432.SCE1572_51325	2.871e-104	363.0	COG0500@1|root,COG2226@2|Bacteria,1MZIX@1224|Proteobacteria,43CDM@68525|delta/epsilon subdivisions,2X7PI@28221|Deltaproteobacteria,2YVQH@29|Myxococcales	28221|Deltaproteobacteria	Q	Mycolic acid cyclopropane synthetase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
HKD2_k127_9965260_1	448385.sce9033	3.101e-88	300.0	COG0688@1|root,COG0688@2|Bacteria,1MVT4@1224|Proteobacteria,42PAW@68525|delta/epsilon subdivisions,2WJV9@28221|Deltaproteobacteria,2Z0GD@29|Myxococcales	28221|Deltaproteobacteria	I	Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer)	-	-	4.1.1.65	ko:K01613	ko00564,ko01100,ko01110,map00564,map01100,map01110	M00093	R02055	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	PS_Dcarbxylase
HKD2_k127_9965260_2	1206729.BAFZ01000128_gene2110	3.484e-69	254.0	COG1960@1|root,COG1960@2|Bacteria,2H3NQ@201174|Actinobacteria,4FY9D@85025|Nocardiaceae	201174|Actinobacteria	I	Acyl-CoA dehydrogenase, middle domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_M
HKD2_k127_9965260_3	448385.sce9037	3.064e-18	92.0	COG0308@1|root,COG0308@2|Bacteria,1RBHC@1224|Proteobacteria,42QWW@68525|delta/epsilon subdivisions,2WMP2@28221|Deltaproteobacteria,2YUU2@29|Myxococcales	28221|Deltaproteobacteria	E	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_19
HKD2_k127_9980466_0	1192034.CAP_5247	2.829e-60	214.0	COG3973@1|root,COG3973@2|Bacteria,1P638@1224|Proteobacteria,42MXR@68525|delta/epsilon subdivisions,2WK1Z@28221|Deltaproteobacteria,2Z32G@29|Myxococcales	28221|Deltaproteobacteria	L	DNA helicase	-	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AAA_19,UvrD_C_2
HKD2_k127_9983894_0	1192034.CAP_1791	4.285e-79	272.0	COG0356@1|root,COG0356@2|Bacteria,1MV87@1224|Proteobacteria,42NR9@68525|delta/epsilon subdivisions,2WKX1@28221|Deltaproteobacteria,2YVR0@29|Myxococcales	28221|Deltaproteobacteria	C	it plays a direct role in the translocation of protons across the membrane	atpB	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016021,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0042777,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1	-	-	ATP-synt_A
HKD2_k127_9983894_5	1192034.CAP_1793	0.0007338	47.0	2AJ7Q@1|root,319SI@2|Bacteria,1Q3U9@1224|Proteobacteria,435C3@68525|delta/epsilon subdivisions,2WZPM@28221|Deltaproteobacteria,2Z2H7@29|Myxococcales	28221|Deltaproteobacteria	S	Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter	-	-	-	-	-	-	-	-	-	-	-	-	ATPase_gene1
HKD2_k127_9983894_1	1254432.SCE1572_45790	5.958e-65	230.0	COG0127@1|root,COG0127@2|Bacteria,1MUK5@1224|Proteobacteria,42NGT@68525|delta/epsilon subdivisions,2WK3E@28221|Deltaproteobacteria,2YVIB@29|Myxococcales	28221|Deltaproteobacteria	F	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions	rdgB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576	3.6.1.66	ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000	-	-	iAF987.Gmet_1875	Ham1p_like
HKD2_k127_9983894_2	1254432.SCE1572_14460	6.625e-56	215.0	COG1720@1|root,COG2026@1|root,COG1720@2|Bacteria,COG2026@2|Bacteria,1MUF0@1224|Proteobacteria,42T7R@68525|delta/epsilon subdivisions,2WNQ2@28221|Deltaproteobacteria,2Z1S5@29|Myxococcales	28221|Deltaproteobacteria	DJ	Uncharacterised protein family UPF0066	-	-	-	-	-	-	-	-	-	-	-	-	UPF0066
HKD2_k127_9995742_3	502025.Hoch_0457	5.006e-25	115.0	COG0454@1|root,COG0456@2|Bacteria,1PVAE@1224|Proteobacteria	1224|Proteobacteria	K	FR47-like protein	-	-	2.3.1.189	ko:K15520	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_1
HKD2_k127_9995742_1	215803.DB30_0025	2.917e-55	201.0	COG1043@1|root,COG1043@2|Bacteria,1MUHQ@1224|Proteobacteria,42NPG@68525|delta/epsilon subdivisions,2WJVP@28221|Deltaproteobacteria,2YYET@29|Myxococcales	28221|Deltaproteobacteria	M	Udp N-acetylglucosamine O-acyltransferase; Domain 2	lpxA	-	2.3.1.129	ko:K00677	ko00540,ko01100,ko01503,map00540,map01100,map01503	M00060	R04567	RC00039,RC00055	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Acetyltransf_11,Hexapep
HKD2_k127_9995742_0	1192034.CAP_4598	4.191e-63	233.0	COG0764@1|root,COG0764@2|Bacteria,1RH2T@1224|Proteobacteria,42SCN@68525|delta/epsilon subdivisions,2WP3E@28221|Deltaproteobacteria,2YVDF@29|Myxococcales	28221|Deltaproteobacteria	I	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs	fabZ	-	4.2.1.59	ko:K02372	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07764,R10117,R10121	RC00831,RC01095	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FabA
HKD2_k127_9995742_2	880072.Desac_2717	4.021e-40	159.0	COG1044@1|root,COG1044@2|Bacteria,1MUX6@1224|Proteobacteria,42M4X@68525|delta/epsilon subdivisions,2WJJY@28221|Deltaproteobacteria,2MQC0@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxD	GO:0003674,GO:0003824,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016740,GO:0016746,GO:0016747,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	2.3.1.191	ko:K02536	ko00540,ko01100,map00540,map01100	M00060	R04550	RC00039,RC00166	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hexapep,Hexapep_2,LpxD
HKD2_k127_9995742_4	448385.sce3122	1.832e-08	56.0	COG2825@1|root,COG2825@2|Bacteria	2|Bacteria	M	unfolded protein binding	ompH	-	-	ko:K06142	-	-	-	-	ko00000	-	-	-	OmpH
## 5947 queries scanned
## Total time (seconds): 48.80517363548279
## Rate: 121.85 q/s