## Tue Feb 17 07:27:36 2026
## emapper-2.1.13
## /data/anaconda3/envs/eggnog-mapper/bin/emapper.py -i /data/result/bins/wyx/bins/HKD2_bin.13.fa -m mmseqs --output HKD2_bin.13 --output_dir /data/result/bins/wyx/eggqs50+/HKD2_bin.13 --itype genome --cpu 8 --override
##
#query	seed_ortholog	evalue	score	eggNOG_OGs	max_annot_lvl	COG_category	Description	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	PFAMs
HKD2_k127_10016925_0	485913.Krac_8662	2.459e-188	599.0	COG0568@1|root,COG0568@2|Bacteria,2G5W3@200795|Chloroflexi	200795|Chloroflexi	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	-	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
HKD2_k127_10016925_1	485913.Krac_8660	2.609e-69	237.0	COG0756@1|root,COG0756@2|Bacteria	2|Bacteria	F	dUTP diphosphatase activity	dut	GO:0000287,GO:0003674,GO:0003824,GO:0004170,GO:0005488,GO:0006139,GO:0006220,GO:0006221,GO:0006226,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009141,GO:0009143,GO:0009147,GO:0009149,GO:0009157,GO:0009162,GO:0009165,GO:0009166,GO:0009176,GO:0009177,GO:0009200,GO:0009204,GO:0009211,GO:0009213,GO:0009219,GO:0009221,GO:0009223,GO:0009262,GO:0009263,GO:0009264,GO:0009265,GO:0009394,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0022607,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0043167,GO:0043169,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046078,GO:0046080,GO:0046081,GO:0046385,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0047429,GO:0051259,GO:0051260,GO:0055086,GO:0065003,GO:0070206,GO:0070207,GO:0071704,GO:0071840,GO:0072527,GO:0072528,GO:0072529,GO:0090407,GO:1901135,GO:1901136,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576	3.6.1.23,4.1.1.36,6.3.2.5	ko:K01520,ko:K13038	ko00240,ko00770,ko00983,ko01100,map00240,map00770,map00983,map01100	M00053,M00120	R02100,R03269,R04231,R11896	RC00002,RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	iYO844.BSU17660	dUTPase
HKD2_k127_10016925_2	485913.Krac_8659	2.609e-24	106.0	COG0484@1|root,COG0484@2|Bacteria	2|Bacteria	O	heat shock protein binding	dnaJ2	-	-	ko:K03686,ko:K05516	-	-	-	-	ko00000,ko03029,ko03036,ko03110	-	-	-	DnaJ,DnaJ_C
HKD2_k127_10036457_0	485913.Krac_8971	3.313e-286	893.0	COG1506@1|root,COG1506@2|Bacteria,2G5NN@200795|Chloroflexi	200795|Chloroflexi	E	Peptidase S9, prolyl oligopeptidase active site domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
HKD2_k127_10056163_0	1382356.JQMP01000003_gene1613	2.018e-113	368.0	COG0022@1|root,COG0022@2|Bacteria,2G84F@200795|Chloroflexi,27XW7@189775|Thermomicrobia	189775|Thermomicrobia	C	Transketolase, pyrimidine binding domain	-	-	-	ko:K21417	-	-	-	-	ko00000,ko01000	-	-	-	Transket_pyr,Transketolase_C
HKD2_k127_10056163_1	1071679.BG57_09780	3.165e-46	184.0	COG0508@1|root,COG0596@1|root,COG0508@2|Bacteria,COG0596@2|Bacteria,1NU1Q@1224|Proteobacteria,2VNCN@28216|Betaproteobacteria,1K2C3@119060|Burkholderiaceae	28216|Betaproteobacteria	C	PFAM alpha beta hydrolase fold	acoC	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Abhydrolase_1,Abhydrolase_6,Biotin_lipoyl
HKD2_k127_10056163_2	485913.Krac_5065	1.843e-16	79.0	COG3360@1|root,COG3360@2|Bacteria,2G9IW@200795|Chloroflexi	200795|Chloroflexi	S	Dodecin	-	-	-	ko:K09165	-	-	-	-	ko00000	-	-	-	Dodecin
HKD2_k127_10062941_0	485913.Krac_7239	9.159e-36	147.0	COG0589@1|root,COG0589@2|Bacteria,2G768@200795|Chloroflexi	200795|Chloroflexi	T	Belongs to the universal stress protein A family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD2_k127_10062941_2	485913.Krac_3443	5.224e-25	105.0	COG1595@1|root,COG1595@2|Bacteria,2G7NX@200795|Chloroflexi	200795|Chloroflexi	K	COGs COG1595 DNA-directed RNA polymerase specialized sigma subunit sigma24 homolog	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD2_k127_10062941_4	485913.Krac_3443	3.569e-05	48.0	COG1595@1|root,COG1595@2|Bacteria,2G7NX@200795|Chloroflexi	200795|Chloroflexi	K	COGs COG1595 DNA-directed RNA polymerase specialized sigma subunit sigma24 homolog	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD2_k127_10062941_1	1121928.AUHE01000016_gene253	1.471e-31	131.0	2BF47@1|root,328WE@2|Bacteria,2IM74@201174|Actinobacteria,4GEAZ@85026|Gordoniaceae	201174|Actinobacteria	S	Domain of unknown function (DUF4203)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4203
HKD2_k127_10062941_3	485913.Krac_3460	2.284e-21	99.0	COG0628@1|root,COG0628@2|Bacteria,2G6TV@200795|Chloroflexi	200795|Chloroflexi	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
HKD2_k127_10067324_1	118166.JH976537_gene557	1.184e-22	104.0	COG1672@1|root,COG1672@2|Bacteria,1G17Z@1117|Cyanobacteria,1HBEI@1150|Oscillatoriales	1117|Cyanobacteria	F	CHAT domain	-	-	-	-	-	-	-	-	-	-	-	-	CHAT,TIR_2
HKD2_k127_10067324_0	485913.Krac_6403	6.364e-33	130.0	COG2963@1|root,COG2963@2|Bacteria	2|Bacteria	L	transposase activity	-	-	-	ko:K07483	-	-	-	-	ko00000	-	-	-	HTH_Tnp_1
HKD2_k127_10067324_2	877411.JMMA01000002_gene1922	8.722e-20	100.0	COG2801@1|root,COG2801@2|Bacteria,1TQQY@1239|Firmicutes,2487W@186801|Clostridia,3WH7Z@541000|Ruminococcaceae	186801|Clostridia	L	Integrase core domain	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve,rve_2
HKD2_k127_10067582_11	485913.Krac_8501	4.469e-13	69.0	COG0712@1|root,COG0712@2|Bacteria,2G78B@200795|Chloroflexi	200795|Chloroflexi	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpH	-	-	ko:K02113	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	OSCP
HKD2_k127_10067582_5	485913.Krac_8500	4.042e-55	199.0	COG0711@1|root,COG0711@2|Bacteria	2|Bacteria	C	ATP synthesis coupled proton transport	atpF	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0031224,GO:0031225,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0036442,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045263,GO:0045264,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	e_coli_core.b3736,iAF1260.b3736,iB21_1397.B21_03564,iBWG_1329.BWG_3427,iE2348C_1286.E2348C_4046,iEC042_1314.EC042_4123,iEC55989_1330.EC55989_4211,iECABU_c1320.ECABU_c42210,iECBD_1354.ECBD_4296,iECB_1328.ECB_03620,iECDH10B_1368.ECDH10B_3923,iECDH1ME8569_1439.ECDH1ME8569_3624,iECD_1391.ECD_03620,iECED1_1282.ECED1_4426,iECH74115_1262.ECH74115_5172,iECIAI1_1343.ECIAI1_3920,iECIAI39_1322.ECIAI39_4340,iECO103_1326.ECO103_4422,iECO111_1330.ECO111_4570,iECO26_1355.ECO26_4842,iECOK1_1307.ECOK1_4185,iECP_1309.ECP_3935,iECS88_1305.ECS88_4158,iECSE_1348.ECSE_4026,iECSF_1327.ECSF_3584,iECSP_1301.ECSP_4786,iECUMN_1333.ECUMN_4266,iECW_1372.ECW_m4039,iECs_1301.ECs4678,iEKO11_1354.EKO11_4609,iETEC_1333.ETEC_4027,iEcDH1_1363.EcDH1_4231,iEcE24377_1341.EcE24377A_4252,iEcHS_1320.EcHS_A3952,iEcSMS35_1347.EcSMS35_4104,iEcolC_1368.EcolC_4258,iG2583_1286.G2583_4532,iJO1366.b3736,iJR904.b3736,iSDY_1059.SDY_4012,iSFV_1184.SFV_3762,iSF_1195.SF3816,iSFxv_1172.SFxv_4159,iSSON_1240.SSON_3883,iS_1188.S3952,iSbBS512_1146.SbBS512_E4185,iUMN146_1321.UM146_18870,iUMNK88_1353.UMNK88_4548,iUTI89_1310.UTI89_C4291,iWFL_1372.ECW_m4039,iY75_1357.Y75_RS18390,iZ_1308.Z5234,ic_1306.c4664	ATP-synt_B
HKD2_k127_10067582_9	485913.Krac_8499	2.65e-20	93.0	COG0636@1|root,COG0636@2|Bacteria,2G72D@200795|Chloroflexi	200795|Chloroflexi	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpE	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02110	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_C
HKD2_k127_10067582_2	485913.Krac_8498	1.782e-95	321.0	COG0356@1|root,COG0356@2|Bacteria,2G6NF@200795|Chloroflexi	200795|Chloroflexi	C	it plays a direct role in the translocation of protons across the membrane	atpB	-	-	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1	-	-	ATP-synt_A
HKD2_k127_10067582_4	485913.Krac_8491	6.332e-58	207.0	298YA@1|root,2ZW25@2|Bacteria,2G6UQ@200795|Chloroflexi	200795|Chloroflexi	S	Protein of unknown function (DUF3090)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3090
HKD2_k127_10067582_12	1382306.JNIM01000001_gene213	0.0001071	44.0	COG1307@1|root,COG1307@2|Bacteria,2G6P2@200795|Chloroflexi	200795|Chloroflexi	S	PFAM DegV family protein	-	-	-	-	-	-	-	-	-	-	-	-	DegV
HKD2_k127_10067582_1	485913.Krac_8487	3.873e-107	356.0	COG1307@1|root,COG1307@2|Bacteria,2G6P2@200795|Chloroflexi	200795|Chloroflexi	S	PFAM DegV family protein	-	-	-	-	-	-	-	-	-	-	-	-	DegV
HKD2_k127_10067582_0	485913.Krac_8486	2.145e-257	804.0	COG1461@1|root,COG1461@2|Bacteria,2G61Z@200795|Chloroflexi	200795|Chloroflexi	S	PFAM Dak phosphatase	-	-	-	ko:K07030	-	-	-	-	ko00000	-	-	-	Dak1_2,Dak2
HKD2_k127_10067582_6	1382306.JNIM01000001_gene215	4.824e-54	192.0	COG1302@1|root,COG1302@2|Bacteria,2G76I@200795|Chloroflexi	200795|Chloroflexi	S	Asp23 family, cell envelope-related function	-	-	-	-	-	-	-	-	-	-	-	-	Asp23
HKD2_k127_10067582_7	485913.Krac_8484	1.147e-32	126.0	COG0227@1|root,COG0227@2|Bacteria	2|Bacteria	J	Belongs to the bacterial ribosomal protein bL28 family	rpmB	-	-	ko:K02902	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L28
HKD2_k127_10073908_0	485913.Krac_4443	2.363e-102	336.0	COG1028@1|root,COG1028@2|Bacteria,2G7U1@200795|Chloroflexi	200795|Chloroflexi	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.1.1.30	ko:K00019	ko00072,ko00650,ko01100,map00072,map00650,map01100	M00088	R01361	RC00117	ko00000,ko00001,ko00002,ko01000	-	-	-	adh_short_C2
HKD2_k127_10073908_1	28072.Nos7524_2323	2.104e-06	50.0	COG2076@1|root,COG2076@2|Bacteria,1G9SH@1117|Cyanobacteria,1HP9J@1161|Nostocales	1117|Cyanobacteria	U	PFAM small multidrug resistance protein	-	-	-	ko:K03297,ko:K11741	-	-	-	-	ko00000,ko02000	2.A.7.1	-	-	Multi_Drug_Res
HKD2_k127_10076866_0	485913.Krac_6827	1.482e-94	315.0	COG1058@1|root,COG1058@2|Bacteria,2G6DU@200795|Chloroflexi	200795|Chloroflexi	S	PFAM molybdopterin binding domain	-	-	-	-	-	-	-	-	-	-	-	-	CinA,MoCF_biosynth
HKD2_k127_10076866_1	1382306.JNIM01000001_gene1018	4.09e-12	78.0	COG1470@1|root,COG1470@2|Bacteria	2|Bacteria	S	cell adhesion involved in biofilm formation	-	-	2.7.11.1	ko:K07004,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	ASH,DUF916,FHA,PG_binding_1,Pkinase
HKD2_k127_10080491_2	1382306.JNIM01000001_gene4114	2.995e-54	192.0	COG0215@1|root,COG0215@2|Bacteria,2G5Z0@200795|Chloroflexi	200795|Chloroflexi	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	-	6.1.1.16,6.3.1.13	ko:K01883,ko:K15526	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e,tRNA-synt_1g
HKD2_k127_10080491_0	485913.Krac_8743	3.035e-129	417.0	COG0084@1|root,COG0084@2|Bacteria,2G6F2@200795|Chloroflexi	200795|Chloroflexi	L	TIGRFAM hydrolase, TatD family	-	-	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
HKD2_k127_10080491_1	485913.Krac_8744	2.143e-63	221.0	COG1490@1|root,COG1490@2|Bacteria,2G6P5@200795|Chloroflexi	200795|Chloroflexi	J	rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality	dtd	GO:0002161,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0051499,GO:0051500,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360	-	ko:K07560	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Tyr_Deacylase
HKD2_k127_10083455_1	1382306.JNIM01000001_gene2816	1.224e-18	86.0	COG0265@1|root,COG0265@2|Bacteria,2G6KV@200795|Chloroflexi	200795|Chloroflexi	O	PFAM peptidase S1 and S6, chymotrypsin Hap	-	-	1.3.1.74	ko:K08070	-	-	-	-	ko00000,ko01000	-	-	-	PDZ_2,Trypsin_2
HKD2_k127_10083455_0	485913.Krac_2323	9.859e-72	248.0	COG0586@1|root,COG0586@2|Bacteria	2|Bacteria	S	FtsZ-dependent cytokinesis	yabI	GO:0000003,GO:0000910,GO:0005575,GO:0005623,GO:0005886,GO:0007049,GO:0008150,GO:0009314,GO:0009628,GO:0009987,GO:0010212,GO:0016020,GO:0019954,GO:0022402,GO:0022414,GO:0032505,GO:0043093,GO:0044464,GO:0050896,GO:0051301,GO:0071944	3.6.1.27	ko:K03975,ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	LssY_C,PAP2,SNARE_assoc
HKD2_k127_10083455_2	1122919.KB905549_gene2119	4.383e-14	79.0	COG2318@1|root,COG2318@2|Bacteria,1TWVZ@1239|Firmicutes,4I5QD@91061|Bacilli,272NG@186822|Paenibacillaceae	91061|Bacilli	S	Protein of unknown function (DUF664)	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
HKD2_k127_10085013_1	485913.Krac_6814	7.883e-164	527.0	COG0793@1|root,COG0793@2|Bacteria,2G6A8@200795|Chloroflexi	200795|Chloroflexi	M	Belongs to the peptidase S41A family	-	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_S41
HKD2_k127_10085013_2	485913.Krac_6815	2.615e-144	462.0	COG0119@1|root,COG0119@2|Bacteria,2G7M0@200795|Chloroflexi	200795|Chloroflexi	E	PFAM pyruvate carboxyltransferase	-	-	4.1.3.4	ko:K01640	ko00072,ko00280,ko00281,ko00650,ko01100,ko04146,map00072,map00280,map00281,map00650,map01100,map04146	M00036,M00088	R01360,R08090	RC00502,RC00503,RC01118,RC01946	ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like
HKD2_k127_10085013_0	485913.Krac_6816	3.846e-204	645.0	COG1253@1|root,COG1253@2|Bacteria,2G6D1@200795|Chloroflexi	200795|Chloroflexi	S	CBS domain containing protein	-	-	-	ko:K03699	-	-	-	-	ko00000,ko02042	-	-	-	CBS,CorC_HlyC,DUF21
HKD2_k127_10096880_0	485913.Krac_12157	0.0	1509.0	COG0525@1|root,COG0525@2|Bacteria,2G5VS@200795|Chloroflexi	200795|Chloroflexi	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
HKD2_k127_10097755_1	485913.Krac_6492	2.649e-111	361.0	COG3316@1|root,COG3316@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,Transposase_mut,zf-IS66
HKD2_k127_10097755_0	1382306.JNIM01000001_gene1179	0.0	1024.0	COG0465@1|root,COG0465@2|Bacteria,2G5J3@200795|Chloroflexi	200795|Chloroflexi	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,Peptidase_M41
HKD2_k127_1010396_0	102125.Xen7305DRAFT_00049660	2.145e-71	255.0	COG4913@1|root,COG4913@2|Bacteria	2|Bacteria	D	Putative exonuclease SbcCD, C subunit	-	-	-	-	-	-	-	-	-	-	-	-	AAA_29,SbcCD_C
HKD2_k127_10133933_0	485913.Krac_8046	3.046e-229	724.0	COG3127@1|root,COG3127@2|Bacteria,2G7QS@200795|Chloroflexi	200795|Chloroflexi	Q	COGs COG3127 ABC-type transport system involved in lysophospholipase L1 biosynthesis permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HKD2_k127_10133933_1	485913.Krac_8047	6.727e-15	75.0	COG1136@1|root,COG1136@2|Bacteria,2G8CR@200795|Chloroflexi	200795|Chloroflexi	V	COGs COG1136 ABC-type antimicrobial peptide transport system ATPase component	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD2_k127_10161345_2	478801.Ksed_13190	1.537e-05	56.0	COG0166@1|root,COG0166@2|Bacteria,2I0N0@201174|Actinobacteria,1ZVBE@145357|Dermacoccaceae	201174|Actinobacteria	G	Belongs to the GPI family	-	-	5.3.1.9	ko:K01810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114	R02739,R02740,R03321	RC00376,RC00563	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGI
HKD2_k127_10161345_1	502025.Hoch_5296	3.278e-74	258.0	COG0656@1|root,COG0656@2|Bacteria,1MX6S@1224|Proteobacteria,4383U@68525|delta/epsilon subdivisions,2X3DT@28221|Deltaproteobacteria,2YVM7@29|Myxococcales	28221|Deltaproteobacteria	S	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
HKD2_k127_10161345_0	485913.Krac_1950	8.594e-168	531.0	COG2141@1|root,COG2141@2|Bacteria,2G5JS@200795|Chloroflexi	200795|Chloroflexi	C	PFAM Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
HKD2_k127_10171999_4	485913.Krac_11904	3.987e-129	428.0	COG0524@1|root,COG0524@2|Bacteria,2G67T@200795|Chloroflexi	200795|Chloroflexi	H	pfkB family carbohydrate kinase	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
HKD2_k127_10171999_9	485913.Krac_11902	3.319e-61	217.0	COG0746@1|root,COG0746@2|Bacteria,2G786@200795|Chloroflexi	200795|Chloroflexi	H	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor	mobA	-	2.7.7.77	ko:K03752	ko00790,ko01100,map00790,map01100	-	R11581	-	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3,NTPase_1
HKD2_k127_10171999_2	485913.Krac_11901	1.027e-169	541.0	COG1304@1|root,COG1304@2|Bacteria,2G5RF@200795|Chloroflexi	200795|Chloroflexi	H	Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP)	fni	-	5.3.3.2	ko:K01823	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00095,M00096,M00364,M00365,M00366,M00367	R01123	RC00455	ko00000,ko00001,ko00002,ko01000	-	-	-	FMN_dh
HKD2_k127_10171999_0	485913.Krac_11899	1.43e-233	728.0	COG0015@1|root,COG0015@2|Bacteria,2G607@200795|Chloroflexi	200795|Chloroflexi	F	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily	purB	-	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	-	ADSL_C,ASL_C,Lyase_1
HKD2_k127_10171999_10	485913.Krac_11898	3.953e-33	130.0	COG0254@1|root,COG0254@2|Bacteria,2G75A@200795|Chloroflexi	200795|Chloroflexi	J	Binds the 23S rRNA	rpmE	-	-	ko:K02909	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L31
HKD2_k127_10171999_1	485913.Krac_11897	2.363e-189	602.0	COG0707@1|root,COG0707@2|Bacteria,2G6CA@200795|Chloroflexi	200795|Chloroflexi	M	Glycosyltransferase 28 domain	-	-	2.4.1.46	ko:K03715	ko00561,ko01100,map00561,map01100	-	R02691	RC00005,RC00059	ko00000,ko00001,ko01000,ko01003	-	GT28	-	Glyco_tran_28_C,MGDG_synth
HKD2_k127_10171999_7	1382306.JNIM01000001_gene2820	9.655e-88	296.0	COG2453@1|root,COG2453@2|Bacteria,2G7AB@200795|Chloroflexi	200795|Chloroflexi	T	PFAM Dual specificity protein phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	DSPc
HKD2_k127_10171999_6	485913.Krac_11894	1.656e-107	355.0	COG0561@1|root,COG0561@2|Bacteria,2G74S@200795|Chloroflexi	200795|Chloroflexi	S	Haloacid dehalogenase domain protein hydrolase, type 3	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_3
HKD2_k127_10171999_5	485913.Krac_11893	6.36e-120	390.0	COG1078@1|root,COG1078@2|Bacteria,2G8B8@200795|Chloroflexi	200795|Chloroflexi	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	-	-	-	-	-	-	-	-	-	HD
HKD2_k127_10174173_1	1499967.BAYZ01000026_gene1631	9.539e-64	226.0	COG0367@1|root,COG0367@2|Bacteria,2NNKE@2323|unclassified Bacteria	2|Bacteria	E	PFAM asparagine synthase	asnB	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
HKD2_k127_10174173_0	1382306.JNIM01000001_gene3879	1.085e-183	580.0	COG1004@1|root,COG1004@2|Bacteria,2G62F@200795|Chloroflexi	200795|Chloroflexi	C	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	-	-	1.1.1.22	ko:K00012	ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100	M00014,M00129,M00361,M00362	R00286	RC00291	ko00000,ko00001,ko00002,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
HKD2_k127_1023576_0	1382306.JNIM01000001_gene1162	1.499e-149	504.0	COG0642@1|root,COG2205@2|Bacteria,2G7J9@200795|Chloroflexi	200795|Chloroflexi	T	histidine kinase A domain protein	-	-	2.7.13.3	ko:K11527	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	GAF,GAF_2,GAF_3,HAMP,HATPase_c,HisKA,dCache_1
HKD2_k127_1026257_1	485913.Krac_7486	5.637e-44	164.0	COG0745@1|root,COG0745@2|Bacteria	485913.Krac_7486|-	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1026257_0	485913.Krac_6492	7.956e-55	195.0	COG3316@1|root,COG3316@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,Transposase_mut,zf-IS66
HKD2_k127_1028205_0	1382306.JNIM01000001_gene1366	1.408e-233	731.0	COG1227@1|root,COG1227@2|Bacteria	2|Bacteria	C	inorganic diphosphatase activity	ppaC	-	3.6.1.1	ko:K15986	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	CBS,DHH,DHHA2,DRTGG
HKD2_k127_1028205_1	485913.Krac_7672	1.493e-125	406.0	COG3808@1|root,COG3808@2|Bacteria,2G5N7@200795|Chloroflexi	200795|Chloroflexi	C	Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
HKD2_k127_104073_0	485913.Krac_7569	5.425e-158	512.0	COG3540@1|root,COG3540@2|Bacteria,2G9SZ@200795|Chloroflexi	200795|Chloroflexi	P	Alkaline phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_104073_1	266117.Rxyl_0670	7.013e-75	256.0	COG2030@1|root,COG2030@2|Bacteria,2GN4R@201174|Actinobacteria,4CQDJ@84995|Rubrobacteria	84995|Rubrobacteria	I	MaoC like domain	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydratas
HKD2_k127_104073_2	1382306.JNIM01000001_gene4100	2.258e-26	115.0	COG0745@1|root,COG0745@2|Bacteria,2G5TG@200795|Chloroflexi	200795|Chloroflexi	K	Two component transcriptional regulator, winged helix family	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
HKD2_k127_1044543_0	485913.Krac_7760	1.034e-94	313.0	COG0110@1|root,COG0110@2|Bacteria,2G7B9@200795|Chloroflexi	200795|Chloroflexi	S	PFAM transferase hexapeptide repeat containing protein	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep
HKD2_k127_1044543_2	1122132.AQYH01000003_gene3175	4.098e-19	96.0	COG0726@1|root,COG0726@2|Bacteria,1MVKH@1224|Proteobacteria,2TTEI@28211|Alphaproteobacteria,4B7YH@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
HKD2_k127_1046489_0	485913.Krac_11214	8.07e-172	546.0	COG2268@1|root,COG2268@2|Bacteria,2G7FP@200795|Chloroflexi	200795|Chloroflexi	S	prohibitin homologues	-	-	-	-	-	-	-	-	-	-	-	-	Band_7,Flot
HKD2_k127_1046489_1	485913.Krac_11213	8.768e-64	228.0	COG1585@1|root,COG1585@2|Bacteria,2G9JI@200795|Chloroflexi	200795|Chloroflexi	OU	Membrane protein implicated in regulation of membrane protease activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1046489_2	485913.Krac_11211	3.091e-55	198.0	COG1396@1|root,COG1396@2|Bacteria	2|Bacteria	K	sequence-specific DNA binding	-	-	2.1.1.72	ko:K03427	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	HTH_3,HTH_31,HsdM_N,N6_Mtase
HKD2_k127_1046489_3	485913.Krac_11208	2.769e-34	133.0	COG2366@1|root,COG2366@2|Bacteria,2G63N@200795|Chloroflexi	200795|Chloroflexi	S	PFAM peptidase S45 penicillin amidase	-	-	3.5.1.11	ko:K01434	ko00311,ko01130,map00311,map01130	-	R02170	RC00166,RC00328	ko00000,ko00001,ko01000,ko01002	-	-	-	Penicil_amidase
HKD2_k127_1047959_1	1382306.JNIM01000001_gene1877	1.51e-121	393.0	COG2872@1|root,COG2872@2|Bacteria	2|Bacteria	S	Ser-tRNA(Ala) hydrolase activity	alaS2	GO:0000049,GO:0002161,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0097159,GO:0106074,GO:0140098,GO:0140101,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.1.1.7	ko:K01872,ko:K07050	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2c,tRNA_SAD
HKD2_k127_1047959_0	485913.Krac_0966	0.0	1790.0	COG0060@1|root,COG0060@2|Bacteria,2G5SN@200795|Chloroflexi	200795|Chloroflexi	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	-	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
HKD2_k127_1047959_3	1123368.AUIS01000013_gene853	1.718e-17	85.0	COG2084@1|root,COG2084@2|Bacteria,1P0X0@1224|Proteobacteria,1RPXF@1236|Gammaproteobacteria,2NCJ9@225057|Acidithiobacillales	225057|Acidithiobacillales	I	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_11,NAD_binding_2
HKD2_k127_1047959_2	870187.Thini_3925	8.24e-74	254.0	COG3039@1|root,COG3039@2|Bacteria,1Q9AW@1224|Proteobacteria,1RNU1@1236|Gammaproteobacteria,460GH@72273|Thiotrichales	72273|Thiotrichales	L	PFAM Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_3
HKD2_k127_1059243_0	1382306.JNIM01000001_gene438	4.727e-48	176.0	COG5305@1|root,COG5305@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HKD2_k127_107404_0	485913.Krac_6683	1.812e-216	676.0	COG0476@1|root,COG0476@2|Bacteria,2G5TN@200795|Chloroflexi	200795|Chloroflexi	HP	PFAM UBA THIF-type NAD FAD binding protein	-	-	2.7.7.80,2.8.1.11	ko:K21029,ko:K21147	ko04122,map04122	-	R07459,R07461	RC00043	ko00000,ko00001,ko01000	-	-	-	Rhodanese,ThiF
HKD2_k127_107404_3	485913.Krac_6682	1.581e-37	142.0	COG1977@1|root,COG1977@2|Bacteria,2G74G@200795|Chloroflexi	200795|Chloroflexi	H	PFAM thiamineS protein	-	-	-	ko:K03636	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
HKD2_k127_107404_1	1382306.JNIM01000001_gene1035	1.981e-166	526.0	COG0031@1|root,COG0031@2|Bacteria,2G698@200795|Chloroflexi	200795|Chloroflexi	E	PFAM Pyridoxal-5'-phosphate-dependent protein beta subunit	-	-	2.5.1.47,4.2.1.22	ko:K01697,ko:K01738,ko:K12339	ko00260,ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00260,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021,M00035,M00338	R00891,R00897,R01290,R03132,R03601,R04859,R04942	RC00020,RC00056,RC00069,RC00256,RC00489,RC01246,RC02814,RC02821,RC02876	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HKD2_k127_107404_2	485913.Krac_6680	4.945e-62	216.0	COG1310@1|root,COG1310@2|Bacteria	2|Bacteria	S	proteolysis	mec	-	3.13.1.6	ko:K21140	ko04122,map04122	-	R11524	RC00064,RC00090	ko00000,ko00001,ko01000	-	-	-	Prok-JAB
HKD2_k127_1094795_1	485913.Krac_9066	2e-07	52.0	COG0604@1|root,COG0604@2|Bacteria	2|Bacteria	C	NADPH:quinone reductase activity	-	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N,ADH_zinc_N_2
HKD2_k127_1094795_0	1382306.JNIM01000001_gene1313	4.888e-200	637.0	COG4745@1|root,COG4745@2|Bacteria,2G6HI@200795|Chloroflexi	200795|Chloroflexi	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HKD2_k127_110299_2	1382306.JNIM01000001_gene1962	4.478e-88	306.0	COG4447@1|root,COG4447@2|Bacteria,2G66V@200795|Chloroflexi	200795|Chloroflexi	G	glycosyl hydrolase, BNR repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_110299_1	485913.Krac_1000	4.093e-144	462.0	COG1351@1|root,COG1351@2|Bacteria,2G7F2@200795|Chloroflexi	200795|Chloroflexi	F	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant	thyX	-	2.1.1.148	ko:K03465	ko00240,ko00670,ko01100,map00240,map00670,map01100	-	R06613	RC00022,RC00332	ko00000,ko00001,ko01000	-	-	-	Thy1
HKD2_k127_110299_0	1382306.JNIM01000001_gene1906	2.878e-184	579.0	COG2896@1|root,COG2896@2|Bacteria,2G5JT@200795|Chloroflexi	200795|Chloroflexi	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	-	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Mob_synth_C,Radical_SAM
HKD2_k127_110299_6	485913.Krac_11244	4.162e-22	96.0	COG0675@1|root,COG0675@2|Bacteria,2G7TJ@200795|Chloroflexi	2|Bacteria	L	TIGRFAM transposase, IS605 OrfB family, central region	-	-	-	ko:K07496	-	-	-	-	ko00000	-	-	-	OrfB_IS605,OrfB_Zn_ribbon
HKD2_k127_1110748_0	1382306.JNIM01000001_gene4058	9.887e-136	445.0	COG1251@1|root,COG1251@2|Bacteria,2G6YZ@200795|Chloroflexi	200795|Chloroflexi	C	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2
HKD2_k127_1110748_1	1382306.JNIM01000001_gene4057	5.217e-86	295.0	29XJW@1|root,30JAY@2|Bacteria,2G9IH@200795|Chloroflexi	200795|Chloroflexi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1111874_3	485913.Krac_8811	2.627e-13	79.0	COG0631@1|root,COG0631@2|Bacteria,2G8I1@200795|Chloroflexi	200795|Chloroflexi	T	Protein phosphatase 2C domain protein	-	-	3.1.3.16	ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C,PP2C_2
HKD2_k127_1111874_0	485913.Krac_8812	5.51e-288	900.0	COG0515@1|root,COG0515@2|Bacteria,2G850@200795|Chloroflexi	200795|Chloroflexi	KLT	Serine threonine protein kinase	-	-	2.7.11.1	ko:K08884	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	FHA,Pkinase,TPR_8
HKD2_k127_1111874_2	485913.Krac_8813	2.739e-115	381.0	COG0631@1|root,COG0631@2|Bacteria,2G8I1@200795|Chloroflexi	200795|Chloroflexi	T	Protein phosphatase 2C domain protein	-	-	3.1.3.16	ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C,PP2C_2
HKD2_k127_1111874_1	485913.Krac_8814	6.307e-194	611.0	COG1160@1|root,COG1160@2|Bacteria,2G5M0@200795|Chloroflexi	200795|Chloroflexi	S	GTPase that plays an essential role in the late steps of ribosome biogenesis	der	-	-	ko:K03977	-	-	-	-	ko00000,ko03009	-	-	-	KH_dom-like,MMR_HSR1
HKD2_k127_1124161_2	485913.Krac_7542	7.177e-15	83.0	COG1187@1|root,COG1187@2|Bacteria	2|Bacteria	J	pseudouridine synthase activity	rluB	-	5.4.99.22	ko:K06178	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
HKD2_k127_1124161_0	485913.Krac_7543	3.831e-194	607.0	COG1313@1|root,COG1313@2|Bacteria,2G65I@200795|Chloroflexi	200795|Chloroflexi	C	Radical SAM domain protein	-	-	1.97.1.4	ko:K04070	-	-	-	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
HKD2_k127_1124161_1	485913.Krac_7544	8.451e-35	134.0	COG0142@1|root,COG0142@2|Bacteria,2G6IZ@200795|Chloroflexi	200795|Chloroflexi	H	Belongs to the FPP GGPP synthase family	hepT	-	2.5.1.30,2.5.1.90	ko:K00805,ko:K02523	ko00900,ko01110,map00900,map01110	-	R09247,R09248	RC00279	ko00000,ko00001,ko01000,ko01006	-	-	-	polyprenyl_synt
HKD2_k127_1127667_0	485913.Krac_8614	3.244e-159	507.0	COG1138@1|root,COG1138@2|Bacteria,2G5SZ@200795|Chloroflexi	200795|Chloroflexi	O	PFAM Cytochrome C assembly protein	ccmF	-	-	ko:K02198	-	-	-	-	ko00000,ko02000	9.B.14.1	-	-	CcmF_C,Cytochrom_C_asm
HKD2_k127_1127667_1	1382306.JNIM01000001_gene135	7.994e-55	196.0	COG2332@1|root,COG2332@2|Bacteria,2G7CS@200795|Chloroflexi	200795|Chloroflexi	O	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH	-	-	-	ko:K02197	-	-	-	-	ko00000	-	-	-	CcmE
HKD2_k127_1127667_2	485913.Krac_8617	4.96e-48	178.0	COG0526@1|root,COG0526@2|Bacteria,2G737@200795|Chloroflexi	200795|Chloroflexi	CO	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	-	-	-	ko:K02199	-	-	-	-	ko00000,ko03110	-	-	-	AhpC-TSA,DnaJ
HKD2_k127_1142858_1	926550.CLDAP_36220	3.104e-13	71.0	COG0399@1|root,COG0399@2|Bacteria,2G5QG@200795|Chloroflexi	200795|Chloroflexi	E	aromatic amino acid beta-eliminating lyase threonine aldolase	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
HKD2_k127_1142858_0	1382306.JNIM01000001_gene2906	1.509e-220	691.0	COG2224@1|root,COG2224@2|Bacteria,2G61J@200795|Chloroflexi	200795|Chloroflexi	C	PFAM isocitrate lyase and phosphorylmutase	-	-	4.1.3.1	ko:K01637	ko00630,ko01100,ko01110,ko01120,ko01200,map00630,map01100,map01110,map01120,map01200	M00012	R00479	RC00311,RC00313	ko00000,ko00001,ko00002,ko01000	-	-	-	ICL
HKD2_k127_1162980_2	485913.Krac_6746	6.787e-09	58.0	COG0515@1|root,COG0515@2|Bacteria	485913.Krac_6746|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1162980_1	485913.Krac_6744	4.013e-223	698.0	COG0536@1|root,COG0536@2|Bacteria,2G5ZT@200795|Chloroflexi	200795|Chloroflexi	S	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control	obg	-	-	ko:K03979	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	DUF1967,GTP1_OBG,MMR_HSR1
HKD2_k127_1162980_0	485913.Krac_6743	0.0	1368.0	COG0457@1|root,COG4995@1|root,COG0457@2|Bacteria,COG4995@2|Bacteria,2G93Q@200795|Chloroflexi	200795|Chloroflexi	K	CHAT domain	-	-	-	-	-	-	-	-	-	-	-	-	CHAT,TPR_12
HKD2_k127_1166670_0	485913.Krac_11060	3.477e-218	687.0	COG0515@1|root,COG0515@2|Bacteria,2G67H@200795|Chloroflexi	485913.Krac_11060|-	KLT	SMART serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1173236_2	485913.Krac_8871	1.069e-49	179.0	COG1733@1|root,COG1733@2|Bacteria	2|Bacteria	K	regulation of RNA biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	HxlR
HKD2_k127_1173236_0	485913.Krac_8872	2.35e-85	284.0	COG0537@1|root,COG0537@2|Bacteria,2G6SB@200795|Chloroflexi	200795|Chloroflexi	FG	Histidine triad (HIT) protein	-	-	2.7.7.53	ko:K19710	ko00230,map00230	-	R00126,R01618	RC00002,RC02753,RC02795	ko00000,ko00001,ko01000	-	-	-	HIT,NUDIX
HKD2_k127_1173236_1	485913.Krac_9241	9.045e-81	272.0	COG0745@1|root,COG0745@2|Bacteria,2G6A5@200795|Chloroflexi	200795|Chloroflexi	K	Two component transcriptional regulator, winged helix family	-	-	-	ko:K02483	-	-	-	-	ko00000,ko02022	-	-	-	Response_reg,Trans_reg_C
HKD2_k127_1173236_3	485913.Krac_10460	1.74e-06	51.0	COG3547@1|root,COG3547@2|Bacteria	2|Bacteria	L	Transposase (IS116 IS110 IS902 family)	-	-	-	ko:K07486	-	-	-	-	ko00000	-	-	-	DEDD_Tnp_IS110,Transposase_20
HKD2_k127_120249_1	485913.Krac_1176	3.186e-69	236.0	COG0745@1|root,COG0745@2|Bacteria,2G5TG@200795|Chloroflexi	200795|Chloroflexi	K	Two component transcriptional regulator, winged helix family	-	-	-	ko:K07669	ko02020,map02020	M00460	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
HKD2_k127_120249_0	485913.Krac_3213	4.085e-78	267.0	COG0477@1|root,COG0477@2|Bacteria	2|Bacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD2_k127_1215917_2	485913.Krac_11276	7.366e-16	79.0	COG1211@1|root,COG1211@2|Bacteria,2G6UP@200795|Chloroflexi	200795|Chloroflexi	I	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP)	ispD	-	2.7.7.60	ko:K00991	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	IspD
HKD2_k127_1215917_1	926569.ANT_30570	1.169e-98	335.0	COG4956@1|root,COG4956@2|Bacteria,2G5YK@200795|Chloroflexi	200795|Chloroflexi	S	SMART Nucleotide binding protein, PINc	-	-	-	-	-	-	-	-	-	-	-	-	TRAM
HKD2_k127_1215917_0	485913.Krac_11274	6.384e-253	786.0	COG1066@1|root,COG1066@2|Bacteria,2G5TE@200795|Chloroflexi	200795|Chloroflexi	L	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function	radA	-	-	ko:K04485	-	-	-	-	ko00000,ko03400	-	-	-	AAA_25,ATPase,ChlI
HKD2_k127_1220093_2	485913.Krac_2795	6.409e-46	167.0	COG0602@1|root,COG0602@2|Bacteria	2|Bacteria	H	queuosine metabolic process	queE	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0008144,GO:0016829,GO:0016840,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0046872,GO:0046983,GO:0048037,GO:0050662,GO:0051536,GO:0051539,GO:0051540,GO:1901681,GO:1904047	1.97.1.4,4.3.99.3	ko:K04068,ko:K10026	ko00790,ko01100,map00790,map01100	-	R04710,R10002	RC02989	ko00000,ko00001,ko01000,ko03016	-	-	-	Fer4_12,Fer4_14,Radical_SAM
HKD2_k127_1220093_0	485913.Krac_2794	3.397e-89	299.0	COG0302@1|root,COG0302@2|Bacteria,2G6VZ@200795|Chloroflexi	200795|Chloroflexi	H	PFAM GTP cyclohydrolase I	folE	-	3.5.4.16	ko:K01495	ko00790,ko01100,map00790,map01100	M00126,M00841,M00842,M00843	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	-	GTP_cyclohydroI
HKD2_k127_1220093_1	485913.Krac_2292	8.585e-77	259.0	COG0667@1|root,COG0667@2|Bacteria	2|Bacteria	C	Aldo Keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
HKD2_k127_1226793_2	1382306.JNIM01000001_gene77	3.852e-43	158.0	COG1003@1|root,COG1003@2|Bacteria,2G5MU@200795|Chloroflexi	200795|Chloroflexi	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPB	-	1.4.4.2	ko:K00281,ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko00002,ko01000	-	-	-	GDC-P
HKD2_k127_1226793_1	1173028.ANKO01000193_gene5867	1.158e-66	248.0	COG0515@1|root,COG2319@1|root,COG0515@2|Bacteria,COG2319@2|Bacteria,1G4N6@1117|Cyanobacteria	1117|Cyanobacteria	KLT	Serine Threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase,WD40
HKD2_k127_1226793_0	485913.Krac_8902	1.374e-210	662.0	COG0465@1|root,COG0465@2|Bacteria,2G63X@200795|Chloroflexi	200795|Chloroflexi	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	-	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
HKD2_k127_122700_3	485913.Krac_1351	2.631e-10	63.0	2BBY6@1|root,325GN@2|Bacteria,2G746@200795|Chloroflexi	200795|Chloroflexi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_122700_1	1382306.JNIM01000001_gene3365	1.831e-87	295.0	COG4280@1|root,COG4280@2|Bacteria,2G81A@200795|Chloroflexi	200795|Chloroflexi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_122700_2	485913.Krac_1348	7.97e-47	170.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_2,Methyltransf_25
HKD2_k127_122794_0	485913.Krac_11961	8.623e-70	253.0	COG1404@1|root,COG1404@2|Bacteria,2G9ID@200795|Chloroflexi	2|Bacteria	O	PFAM peptidase S8 and S53, subtilisin, kexin, sedolisin	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8,SLH
HKD2_k127_1266123_0	485913.Krac_2798	6.501e-117	380.0	COG0603@1|root,COG0603@2|Bacteria,2G8ZG@200795|Chloroflexi	200795|Chloroflexi	H	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))	queC	-	6.3.4.20	ko:K06920	ko00790,ko01100,map00790,map01100	-	R09978	RC00959	ko00000,ko00001,ko01000,ko03016	-	-	-	QueC
HKD2_k127_1266123_1	485913.Krac_2799	3.579e-72	245.0	COG0780@1|root,COG0780@2|Bacteria,2G9AQ@200795|Chloroflexi	200795|Chloroflexi	S	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)	queF	-	1.7.1.13	ko:K09457	ko00790,ko01100,map00790,map01100	-	R07605	RC01875	ko00000,ko00001,ko01000,ko03016	-	-	-	QueF
HKD2_k127_1266123_2	485913.Krac_2804	1.113e-19	90.0	COG0631@1|root,COG0631@2|Bacteria,2G8RD@200795|Chloroflexi	2|Bacteria	T	SMART protein phosphatase 2C domain protein	-	-	3.1.3.16	ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C,PP2C_2
HKD2_k127_1274506_1	1232410.KI421412_gene145	1.062e-45	173.0	COG1969@1|root,COG1969@2|Bacteria,1MU87@1224|Proteobacteria,42NQ3@68525|delta/epsilon subdivisions,2X8MJ@28221|Deltaproteobacteria,43TMS@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Domain of unknown function (DUF4405)	-	-	-	-	-	-	-	-	-	-	-	-	Ni_hydr_CYTB
HKD2_k127_1274506_0	1382359.JIAL01000001_gene335	2.191e-270	841.0	COG0374@1|root,COG0374@2|Bacteria,3Y3C2@57723|Acidobacteria,2JJUU@204432|Acidobacteriia	204432|Acidobacteriia	C	Nickel-dependent hydrogenase	-	-	1.12.99.6	ko:K06281	ko00633,ko01120,map00633,map01120	-	R08034	RC00250	ko00000,ko00001,ko01000	-	-	-	NiFeSe_Hases
HKD2_k127_1274506_2	269799.Gmet_3332	1.318e-15	79.0	COG1740@1|root,COG1740@2|Bacteria,1MWAC@1224|Proteobacteria,42MI0@68525|delta/epsilon subdivisions,2WIW4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	TIGRFAM hydrogenase (NiFe) small subunit (hydA)	hyaS	-	1.12.2.1,1.12.99.6	ko:K06282,ko:K18008	ko00633,ko01120,map00633,map01120	-	R08034	RC00250	ko00000,ko00001,ko01000	-	-	iAF987.Gmet_3332	NiFe_hyd_SSU_C,Oxidored_q6,TAT_signal
HKD2_k127_1275520_2	1382306.JNIM01000001_gene3271	7.511e-20	89.0	2DEPM@1|root,2ZNRD@2|Bacteria,2G9FN@200795|Chloroflexi	200795|Chloroflexi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1275520_1	485913.Krac_0950	4.027e-56	202.0	COG0597@1|root,COG0597@2|Bacteria,2G740@200795|Chloroflexi	200795|Chloroflexi	M	This protein specifically catalyzes the removal of signal peptides from prolipoproteins	lspA	-	3.4.23.36	ko:K03101	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_A8
HKD2_k127_1275520_0	485913.Krac_0949	6.837e-84	286.0	COG0564@1|root,COG0564@2|Bacteria,2G68N@200795|Chloroflexi	200795|Chloroflexi	J	Responsible for synthesis of pseudouridine from uracil	-	GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
HKD2_k127_1281708_0	485913.Krac_11155	4.612e-230	723.0	COG0591@1|root,COG0591@2|Bacteria	2|Bacteria	E	symporter activity	yodF	-	-	ko:K03307	-	-	-	-	ko00000	2.A.21	-	-	SSF
HKD2_k127_1293625_0	671143.DAMO_0621	0.0	1049.0	COG1452@1|root,COG1452@2|Bacteria	2|Bacteria	M	lipopolysaccharide transport	-	-	-	ko:K22110	-	-	-	-	ko00000,ko02000	1.B.35.1,1.B.35.2	-	-	Glyco_hydro_63
HKD2_k127_1293625_1	765914.ThisiDRAFT_1820	0.0004293	44.0	COG3293@1|root,COG3293@2|Bacteria,1N9RE@1224|Proteobacteria	1224|Proteobacteria	L	PFAM Transposase, IS4-like	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_2
HKD2_k127_1308948_0	1382306.JNIM01000001_gene1400	3.669e-104	345.0	COG0586@1|root,COG0586@2|Bacteria,2G70A@200795|Chloroflexi	200795|Chloroflexi	S	PFAM SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
HKD2_k127_1320166_0	485913.Krac_12183	8.898e-156	497.0	COG0332@1|root,COG0332@2|Bacteria,2G630@200795|Chloroflexi	200795|Chloroflexi	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	-	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
HKD2_k127_1320166_3	1382306.JNIM01000001_gene3725	3.132e-44	164.0	COG1278@1|root,COG1278@2|Bacteria,2G79W@200795|Chloroflexi	200795|Chloroflexi	K	Probable zinc-ribbon domain	-	-	-	-	-	-	-	-	-	-	-	-	zf-trcl
HKD2_k127_1320166_2	485913.Krac_12185	3.115e-54	199.0	COG0491@1|root,COG0491@2|Bacteria	2|Bacteria	GM	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B,TPR_16
HKD2_k127_1320166_1	485913.Krac_11289	7.495e-86	295.0	COG3363@1|root,COG3363@2|Bacteria	2|Bacteria	F	IMP cyclohydrolase activity	purN	-	2.1.2.2	ko:K11175	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	M00048	R04325,R04326	RC00026,RC00197,RC01128	ko00000,ko00001,ko00002,ko01000	-	-	-	IMP_cyclohyd
HKD2_k127_1320166_4	485913.Krac_12186	3.145e-31	129.0	COG1716@1|root,COG1716@2|Bacteria	2|Bacteria	T	histone H2A K63-linked ubiquitination	-	-	-	ko:K21397	-	-	-	-	ko00000,ko02000	3.A.1	-	-	FHA,Yop-YscD_cpl
HKD2_k127_13228_0	485913.Krac_7603	1.061e-144	469.0	COG0639@1|root,COG0639@2|Bacteria,2G6GC@200795|Chloroflexi	200795|Chloroflexi	T	PFAM metallophosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos_2
HKD2_k127_13228_1	485913.Krac_7604	2.061e-86	292.0	COG0193@1|root,COG0193@2|Bacteria,2G6SW@200795|Chloroflexi	200795|Chloroflexi	J	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis	pth	GO:0003674,GO:0003824,GO:0004045,GO:0016787,GO:0016788,GO:0052689,GO:0140098,GO:0140101	3.1.1.29	ko:K01056	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	Pept_tRNA_hydro
HKD2_k127_13228_2	357808.RoseRS_0701	5.19e-41	157.0	COG4377@1|root,COG4377@2|Bacteria	2|Bacteria	S	Putative membrane peptidase family (DUF2324)	yhfC	-	-	-	-	-	-	-	-	-	-	-	DUF2324
HKD2_k127_1326779_2	485913.Krac_7666	5.855e-57	203.0	COG0294@1|root,COG0294@2|Bacteria,2G6A6@200795|Chloroflexi	200795|Chloroflexi	H	dihydropteroate synthase	folP	-	2.5.1.15	ko:K00796	ko00790,ko01100,map00790,map01100	M00126,M00841	R03066,R03067	RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
HKD2_k127_1326779_3	485913.Krac_6109	3.725e-47	171.0	COG0675@1|root,COG0675@2|Bacteria	2|Bacteria	L	Transposase, IS605 OrfB family	-	-	-	ko:K07496	-	-	-	-	ko00000	-	-	-	OrfB_IS605,OrfB_Zn_ribbon
HKD2_k127_1326779_0	485913.Krac_7668	3.57e-147	475.0	COG0142@1|root,COG0142@2|Bacteria,2G6BM@200795|Chloroflexi	200795|Chloroflexi	H	Belongs to the FPP GGPP synthase family	-	-	2.5.1.1,2.5.1.10,2.5.1.29	ko:K13787	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00365	R01658,R02003,R02061	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
HKD2_k127_1326779_4	1382306.JNIM01000001_gene1368	8.159e-42	158.0	COG2319@1|root,COG2319@2|Bacteria	2|Bacteria	S	anaphase-promoting complex binding	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,WD40,YukD
HKD2_k127_1340112_0	1382306.JNIM01000001_gene219	1.465e-186	592.0	COG2262@1|root,COG2262@2|Bacteria,2G634@200795|Chloroflexi	200795|Chloroflexi	S	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis	hflX	-	-	ko:K03665	-	-	-	-	ko00000,ko03009	-	-	-	GTP-bdg_M,GTP-bdg_N,MMR_HSR1
HKD2_k127_1347747_0	485913.Krac_11885	3.286e-150	475.0	COG0719@1|root,COG0719@2|Bacteria,2G5TI@200795|Chloroflexi	200795|Chloroflexi	O	TIGRFAM FeS assembly protein SufB	sufB	-	-	ko:K07033,ko:K09014	-	-	-	-	ko00000	-	-	-	UPF0051
HKD2_k127_1347747_1	485913.Krac_9928	2.404e-87	298.0	COG0642@1|root,COG2205@2|Bacteria	485913.Krac_9928|-	T	PhoQ Sensor	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1358773_0	479431.Namu_1834	2.144e-73	268.0	COG1215@1|root,COG1215@2|Bacteria,2GKFI@201174|Actinobacteria,4ESRY@85013|Frankiales	201174|Actinobacteria	M	PFAM Glycosyl transferase family 2	-	-	2.4.1.12	ko:K00694	ko00500,ko01100,ko02026,map00500,map01100,map02026	-	R02889	RC00005	ko00000,ko00001,ko01000,ko01003,ko02000	4.D.3.1.2,4.D.3.1.5,4.D.3.1.6	GT2	-	Cellulose_synt,Glyco_tranf_2_3,Glyco_trans_2_3,Glycos_transf_2
HKD2_k127_1358773_2	1123508.JH636444_gene5594	0.0008483	42.0	COG3293@1|root,COG3293@2|Bacteria,2IX9I@203682|Planctomycetes	203682|Planctomycetes	L	PFAM Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF4096
HKD2_k127_1358773_1	1183438.GKIL_4216	3.144e-10	63.0	COG3293@1|root,COG3293@2|Bacteria,1G0BW@1117|Cyanobacteria	1117|Cyanobacteria	L	Transposase	-	-	-	ko:K07492	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DDE_Tnp_1_2,DUF4096
HKD2_k127_1364948_3	485913.Krac_8674	2.223e-46	177.0	COG0330@1|root,COG0330@2|Bacteria	2|Bacteria	O	stress-induced mitochondrial fusion	-	-	-	-	-	-	-	-	-	-	-	-	Band_7,FHA
HKD2_k127_1364948_0	1382306.JNIM01000001_gene3573	1.106e-150	483.0	COG1774@1|root,COG1774@2|Bacteria,2G6AJ@200795|Chloroflexi	200795|Chloroflexi	NU	PFAM PSP1 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PSP1
HKD2_k127_1364948_2	485913.Krac_8671	1.088e-103	339.0	COG3707@1|root,COG3707@2|Bacteria,2G6CD@200795|Chloroflexi	200795|Chloroflexi	T	PFAM response regulator receiver	-	-	-	ko:K22010	-	M00839	-	-	ko00000,ko00002,ko02022	-	-	-	ANTAR,Response_reg
HKD2_k127_1364948_1	485913.Krac_8670	1.836e-147	474.0	COG2876@1|root,COG2876@2|Bacteria,2G643@200795|Chloroflexi	200795|Chloroflexi	E	PFAM DAHP synthetase I KDSA	-	-	-	-	-	-	-	-	-	-	-	-	DAHP_synth_1
HKD2_k127_1368050_0	485913.Krac_7787	4.986e-208	651.0	COG1154@1|root,COG1154@2|Bacteria,2G68R@200795|Chloroflexi	200795|Chloroflexi	F	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)	dxs	-	2.2.1.7	ko:K01662	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	M00096	R05636	RC00032	ko00000,ko00001,ko00002,ko01000	-	-	-	DXP_synthase_N,Transket_pyr,Transketolase_C
HKD2_k127_1368050_3	485913.Krac_7785	1.794e-52	196.0	COG0664@1|root,COG0664@2|Bacteria,2G6WI@200795|Chloroflexi	200795|Chloroflexi	K	PFAM Cyclic nucleotide-binding	-	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
HKD2_k127_1368050_2	485913.Krac_7784	2.989e-76	260.0	COG2197@1|root,COG2197@2|Bacteria,2G6C5@200795|Chloroflexi	2|Bacteria	K	COGs COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HKD2_k127_1368050_1	485913.Krac_6492	1.083e-127	415.0	COG3316@1|root,COG3316@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,Transposase_mut,zf-IS66
HKD2_k127_1369256_4	485913.Krac_11055	2.172e-26	111.0	COG1403@1|root,COG1403@2|Bacteria	2|Bacteria	V	endonuclease activity	-	-	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	HNH,RRXRR
HKD2_k127_1369256_3	485913.Krac_1371	1.121e-37	141.0	COG1837@1|root,COG1837@2|Bacteria,2G7DU@200795|Chloroflexi	200795|Chloroflexi	S	Belongs to the UPF0109 family	-	-	-	ko:K06960	-	-	-	-	ko00000	-	-	-	KH_4
HKD2_k127_1369256_2	485913.Krac_1372	2.37e-43	159.0	COG0228@1|root,COG0228@2|Bacteria,2G7A3@200795|Chloroflexi	200795|Chloroflexi	J	Belongs to the bacterial ribosomal protein bS16 family	rpsP	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02959	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S16
HKD2_k127_1369256_0	485913.Krac_10095	1.524e-246	770.0	COG0531@1|root,COG0531@2|Bacteria	2|Bacteria	E	amino acid	yeeF	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006576,GO:0006595,GO:0006598,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0006928,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008324,GO:0008519,GO:0009056,GO:0009308,GO:0009310,GO:0009445,GO:0009447,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015101,GO:0015203,GO:0015291,GO:0015293,GO:0015294,GO:0015295,GO:0015318,GO:0015489,GO:0015672,GO:0015695,GO:0015696,GO:0015846,GO:0015847,GO:0016020,GO:0022804,GO:0022857,GO:0022890,GO:0033554,GO:0034220,GO:0034641,GO:0040011,GO:0042402,GO:0044106,GO:0044237,GO:0044464,GO:0048870,GO:0050896,GO:0051179,GO:0051234,GO:0051674,GO:0051716,GO:0055085,GO:0071702,GO:0071704,GO:0071705,GO:0071944,GO:0072488,GO:0097164,GO:0098655,GO:0098660,GO:0098662,GO:1901564,GO:1901565,GO:1901575,GO:1902047,GO:1902600	-	ko:K14052	-	-	-	-	ko00000,ko02000	2.A.3.1.13	-	iSBO_1134.SBO_1766	AA_permease,AA_permease_2
HKD2_k127_1369256_6	1509403.GW12_01670	7.112e-06	48.0	COG3039@1|root,COG3039@2|Bacteria,1MXP1@1224|Proteobacteria,1RSBM@1236|Gammaproteobacteria,3NIY5@468|Moraxellaceae	1236|Gammaproteobacteria	L	There are 9 addittional ORFs identical to this one	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_3
HKD2_k127_1369256_1	118166.JH976537_gene4960	5.235e-46	168.0	COG0021@1|root,COG0021@2|Bacteria,1G0GC@1117|Cyanobacteria,1H7T2@1150|Oscillatoriales	2|Bacteria	G	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate	tkt	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
HKD2_k127_1396112_1	485913.Krac_12535	6.384e-308	946.0	COG0085@1|root,COG0085@2|Bacteria,2G5VH@200795|Chloroflexi	200795|Chloroflexi	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
HKD2_k127_1396112_0	485913.Krac_12534	0.0	1536.0	COG0086@1|root,COG0086@2|Bacteria,2G632@200795|Chloroflexi	200795|Chloroflexi	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
HKD2_k127_1401993_2	485913.Krac_8501	9.965e-66	229.0	COG0712@1|root,COG0712@2|Bacteria,2G78B@200795|Chloroflexi	200795|Chloroflexi	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpH	-	-	ko:K02113	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	OSCP
HKD2_k127_1401993_0	485913.Krac_8502	1.344e-278	862.0	COG0056@1|root,COG0056@2|Bacteria,2G5YQ@200795|Chloroflexi	200795|Chloroflexi	F	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	atpA	-	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
HKD2_k127_1401993_1	485913.Krac_8503	6.982e-123	400.0	COG0224@1|root,COG0224@2|Bacteria,2G69I@200795|Chloroflexi	200795|Chloroflexi	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex	atpG	-	-	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt
HKD2_k127_1401993_3	1382306.JNIM01000001_gene199	1.049e-55	198.0	COG0055@1|root,COG0055@2|Bacteria,2G5JI@200795|Chloroflexi	200795|Chloroflexi	F	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits	atpD	-	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_N
HKD2_k127_1402086_0	1382306.JNIM01000001_gene3318	3.784e-70	247.0	COG3947@1|root,COG3947@2|Bacteria	2|Bacteria	T	sequence-specific DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	BTAD,GAF_2,HEAT_2,TPR_12,Trans_reg_C
HKD2_k127_1459900_0	485913.Krac_8467	1.706e-113	371.0	COG0035@1|root,COG0035@2|Bacteria,2G6CS@200795|Chloroflexi	200795|Chloroflexi	F	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate	upp	-	2.4.2.9	ko:K00761	ko00240,ko01100,map00240,map01100	-	R00966	RC00063	ko00000,ko00001,ko01000	-	-	-	UPRTase
HKD2_k127_1459900_1	1382306.JNIM01000001_gene171	6.963e-81	273.0	COG2362@1|root,COG2362@2|Bacteria,2G8M4@200795|Chloroflexi	200795|Chloroflexi	E	PFAM peptidase M55 D-aminopeptidase	-	-	-	ko:K16203	-	-	-	-	ko00000,ko01000,ko01002	3.A.1.5.2	-	-	Peptidase_M55
HKD2_k127_1462522_0	485913.Krac_8226	4.582e-130	427.0	COG0726@1|root,COG0726@2|Bacteria,2G6VJ@200795|Chloroflexi	200795|Chloroflexi	G	Polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
HKD2_k127_1467882_2	1173026.Glo7428_3615	3.832e-18	87.0	COG2331@1|root,COG2331@2|Bacteria	2|Bacteria	P	Regulatory protein, FmdB family	-	-	-	-	-	-	-	-	-	-	-	-	Zn-ribbon_8
HKD2_k127_1467882_1	1173020.Cha6605_3372	5.448e-46	174.0	COG3548@1|root,COG3548@2|Bacteria,1G8WP@1117|Cyanobacteria	1117|Cyanobacteria	S	Protein of unknown function (DUF1211)	-	GO:0003674,GO:0005215,GO:0005216,GO:0005261,GO:0005267,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015267,GO:0015318,GO:0015672,GO:0016043,GO:0022607,GO:0022803,GO:0022838,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0043933,GO:0044085,GO:0046873,GO:0051179,GO:0051234,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055085,GO:0065003,GO:0071804,GO:0071805,GO:0071840,GO:0098655,GO:0098660,GO:0098662	-	-	-	-	-	-	-	-	-	-	DUF1211
HKD2_k127_1467882_0	485913.Krac_3651	9.067e-56	197.0	COG0432@1|root,COG0432@2|Bacteria,2G9B9@200795|Chloroflexi	200795|Chloroflexi	S	Uncharacterised protein family UPF0047	-	-	-	-	-	-	-	-	-	-	-	-	UPF0047
HKD2_k127_1467882_4	485913.Krac_5152	2.52e-11	67.0	COG0589@1|root,COG0589@2|Bacteria,2G94S@200795|Chloroflexi	2|Bacteria	T	COGs COG0589 Universal stress protein UspA and related nucleotide-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD2_k127_147405_0	485913.Krac_4240	1.345e-159	520.0	COG0574@1|root,COG3848@1|root,COG0574@2|Bacteria,COG3848@2|Bacteria,2G6K4@200795|Chloroflexi	200795|Chloroflexi	H	phosphoenolpyruvate synthase	ppsA	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
HKD2_k127_1475492_1	1380347.JNII01000011_gene918	5.932e-79	276.0	COG0053@1|root,COG0053@2|Bacteria,2GJ8Q@201174|Actinobacteria,4EUP4@85013|Frankiales	201174|Actinobacteria	P	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,ZT_dimer
HKD2_k127_1475492_0	485913.Krac_11746	0.0	2070.0	COG0067@1|root,COG0069@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,2G5VK@200795|Chloroflexi	200795|Chloroflexi	E	glutamate synthase, alpha subunit domain protein	gltB	-	1.4.1.13,1.4.1.14,1.4.7.1	ko:K00265,ko:K00284	ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230	-	R00021,R00093,R00114,R00248,R10086	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4_9,GATase_2,GXGXG,Glu_syn_central,Glu_synthase
HKD2_k127_1475492_2	485913.Krac_11755	0.0005016	42.0	COG2352@1|root,COG2352@2|Bacteria,2G62H@200795|Chloroflexi	200795|Chloroflexi	C	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle	ppc	-	4.1.1.31	ko:K01595	ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200	M00168,M00170,M00171,M00172,M00173,M00346,M00374	R00345	RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPcase
HKD2_k127_1486112_0	1173024.KI912151_gene2064	2.875e-75	259.0	COG1926@1|root,COG1926@2|Bacteria,1G2IS@1117|Cyanobacteria,1JKQX@1189|Stigonemataceae	1117|Cyanobacteria	S	Phosphoribosyl transferase domain	-	-	-	ko:K07100	-	-	-	-	ko00000	-	-	-	Pribosyltran
HKD2_k127_1493484_2	261292.Nit79A3_0013	3.545e-17	91.0	COG3266@1|root,COG3266@2|Bacteria	2|Bacteria	GM	domain, Protein	-	-	2.4.1.21	ko:K00703,ko:K07082	ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026	M00565	R02421	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT5	-	AAA_12,DUF559,PGA_cap,WG_beta_rep
HKD2_k127_1493484_1	1267533.KB906737_gene1862	7.244e-23	104.0	COG3064@1|root,COG5164@1|root,COG3064@2|Bacteria,COG5164@2|Bacteria,3Y7SB@57723|Acidobacteria,2JN3R@204432|Acidobacteriia	204432|Acidobacteriia	M	Protein of unknown function (DUF3300)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3300
HKD2_k127_1493484_0	929556.Solca_1935	2.574e-162	529.0	COG5164@1|root,COG5164@2|Bacteria,4NFN0@976|Bacteroidetes	976|Bacteroidetes	K	regulation of DNA-templated transcription, elongation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1493484_3	335659.S23_19590	1.043e-09	59.0	COG3119@1|root,COG3119@2|Bacteria,1MV92@1224|Proteobacteria,2TTXG@28211|Alphaproteobacteria,3JVJZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
HKD2_k127_1501350_2	485913.Krac_8294	1.459e-91	304.0	COG0183@1|root,COG0183@2|Bacteria,2G80D@200795|Chloroflexi	200795|Chloroflexi	I	Belongs to the thiolase family	-	-	2.3.1.16,2.3.1.9	ko:K00626,ko:K00632	ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00087,M00088,M00095,M00113,M00373,M00374,M00375	R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
HKD2_k127_1501350_0	1382306.JNIM01000001_gene390	1.16e-174	556.0	COG2021@1|root,COG2021@2|Bacteria,2G5JD@200795|Chloroflexi	200795|Chloroflexi	E	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine	metXA	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004414,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008374,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009092,GO:0009987,GO:0016053,GO:0016407,GO:0016413,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.3.1.31	ko:K00641	ko00270,ko01100,ko01130,map00270,map01100,map01130	-	R01776	RC00004,RC00041	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1
HKD2_k127_1501350_1	485913.Krac_8302	7.276e-107	348.0	COG2873@1|root,COG2873@2|Bacteria,2G5NS@200795|Chloroflexi	200795|Chloroflexi	E	PFAM Cys Met metabolism pyridoxal-phosphate-dependent protein	-	-	2.5.1.49	ko:K01740	ko00270,ko01100,map00270,map01100	-	R01287,R04859	RC00020,RC02821,RC02848	ko00000,ko00001,ko01000	-	-	-	Cys_Met_Meta_PP
HKD2_k127_1501502_1	1120949.KB903294_gene3936	2.245e-78	284.0	28Q0Z@1|root,2ZCJM@2|Bacteria,2IAZ4@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1501502_0	1120949.KB903294_gene3937	6.013e-93	320.0	COG4675@1|root,COG4675@2|Bacteria	2|Bacteria	M	tail collar domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF859,Laminin_G_3
HKD2_k127_1510457_0	485913.Krac_8234	1.523e-82	276.0	COG1200@1|root,COG1200@2|Bacteria,2G5YM@200795|Chloroflexi	200795|Chloroflexi	L	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)	recG	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge
HKD2_k127_1510457_1	1382306.JNIM01000001_gene3737	1.905e-75	257.0	COG0669@1|root,COG0669@2|Bacteria,2G6NZ@200795|Chloroflexi	200795|Chloroflexi	F	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate	coaD	-	2.7.7.3	ko:K00954	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
HKD2_k127_1517062_0	1114856.C496_05367	2.327e-54	203.0	COG3608@1|root,arCOG02890@2157|Archaea,2XUN3@28890|Euryarchaeota,23TXV@183963|Halobacteria	183963|Halobacteria	S	Succinylglutamate desuccinylase aspartoacylase	-	-	-	-	-	-	-	-	-	-	-	-	AstE_AspA
HKD2_k127_151906_0	485913.Krac_0972	3.358e-145	481.0	COG0515@1|root,COG2319@1|root,COG0515@2|Bacteria,COG2319@2|Bacteria	2|Bacteria	S	anaphase-promoting complex binding	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos,NACHT,PD40,Pentapeptide,Pkinase,TIR_2,WD40
HKD2_k127_1523454_0	485913.Krac_0964	0.0	1395.0	COG0567@1|root,COG0567@2|Bacteria,2G638@200795|Chloroflexi	200795|Chloroflexi	C	The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components 2- oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3)	-	-	1.2.4.2	ko:K00164	ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R00621,R01933,R01940,R03316,R08549	RC00004,RC00027,RC00627,RC02743,RC02833,RC02883	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr
HKD2_k127_1524144_1	485913.Krac_4813	2.584e-88	300.0	COG0474@1|root,COG0474@2|Bacteria,2G5ZS@200795|Chloroflexi	200795|Chloroflexi	P	TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	-	ko:K12955	-	-	-	-	ko00000,ko01000	3.A.3.24	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
HKD2_k127_1524144_0	485913.Krac_7508	1.599e-116	379.0	COG0492@1|root,COG0492@2|Bacteria,2G5Z5@200795|Chloroflexi	200795|Chloroflexi	C	FAD-dependent pyridine nucleotide-disulphide oxidoreductase	trxB	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
HKD2_k127_1528042_0	485913.Krac_10634	7.373e-149	479.0	COG4469@1|root,COG4469@2|Bacteria	2|Bacteria	-	-	coiA	-	-	ko:K06198	-	-	-	-	ko00000	-	-	-	CoiA
HKD2_k127_1528042_1	485913.Krac_9793	2.048e-13	74.0	COG0642@1|root,COG2205@2|Bacteria,2G6KS@200795|Chloroflexi	200795|Chloroflexi	T	histidine kinase A domain protein	-	-	2.7.13.3	ko:K07646	ko02020,map02020	M00454	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	DUF4118,GAF,HATPase_c,HisKA
HKD2_k127_1528735_1	1122182.KB903813_gene2465	4.015e-52	195.0	COG0477@1|root,COG0477@2|Bacteria,2GIUM@201174|Actinobacteria,4DMEQ@85008|Micromonosporales	201174|Actinobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD2_k127_1528735_2	679926.Mpet_1863	2.583e-05	53.0	COG3247@1|root,arCOG03582@2157|Archaea	2157|Archaea	S	Short repeat of unknown function (DUF308)	-	-	-	-	-	-	-	-	-	-	-	-	DUF308
HKD2_k127_1528735_0	485913.Krac_3461	1.26e-55	198.0	COG4803@1|root,COG4803@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF1269
HKD2_k127_1534237_1	485913.Krac_12507	4.299e-68	236.0	COG0563@1|root,COG0563@2|Bacteria,2G6GP@200795|Chloroflexi	200795|Chloroflexi	F	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism	adk	-	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ADK,ADK_lid
HKD2_k127_1534237_0	1382306.JNIM01000001_gene3316	4.529e-250	778.0	COG0473@1|root,COG0473@2|Bacteria,2G7RB@200795|Chloroflexi	200795|Chloroflexi	C	Isocitrate/isopropylmalate dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Iso_dh
HKD2_k127_1538765_0	485913.Krac_9133	4.633e-288	899.0	COG0358@1|root,COG0358@2|Bacteria,2G65X@200795|Chloroflexi	200795|Chloroflexi	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2
HKD2_k127_1538765_1	401526.TcarDRAFT_1766	2.757e-131	431.0	COG0568@1|root,COG0568@2|Bacteria,1TPD6@1239|Firmicutes,4H25A@909932|Negativicutes	909932|Negativicutes	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	sigA	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
HKD2_k127_1540048_0	1382306.JNIM01000001_gene2616	1.888e-253	789.0	COG1132@1|root,COG1132@2|Bacteria,2G66A@200795|Chloroflexi	200795|Chloroflexi	V	ABC transporter, transmembrane region	-	-	-	ko:K06147,ko:K18890	ko02010,map02010	M00707	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.106,3.A.1.106.13,3.A.1.106.5,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
HKD2_k127_1561197_0	314264.ROS217_19912	4.262e-223	707.0	COG0827@1|root,COG1002@1|root,COG0827@2|Bacteria,COG1002@2|Bacteria	2|Bacteria	V	DNA modification	-	-	-	-	-	-	-	-	-	-	-	-	Eco57I,Helicase_C,N6_Mtase,SNF2_N,TaqI_C
HKD2_k127_1571581_1	696281.Desru_3228	3.952e-79	269.0	29Y33@1|root,30JW2@2|Bacteria,1W3SV@1239|Firmicutes,254NF@186801|Clostridia,266AP@186807|Peptococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1571581_0	485913.Krac_11446	4.884e-84	281.0	COG0753@1|root,COG0753@2|Bacteria,2G804@200795|Chloroflexi	2|Bacteria	C	Catalase domain protein	-	-	1.11.1.6	ko:K03781	ko00380,ko00630,ko01110,ko01130,ko01200,ko04011,ko04016,ko04068,ko04146,ko04211,ko04212,ko04213,ko05014,map00380,map00630,map01110,map01130,map01200,map04011,map04016,map04068,map04146,map04211,map04212,map04213,map05014	M00532	R00009,R00602,R02670	RC00034,RC00767,RC02141,RC02755	ko00000,ko00001,ko00002,ko01000	-	-	-	Catalase,Catalase-rel
HKD2_k127_1575581_2	448385.sce2119	2.828e-35	137.0	COG4948@1|root,COG4948@2|Bacteria,1MYZE@1224|Proteobacteria,42MY9@68525|delta/epsilon subdivisions,2WKS9@28221|Deltaproteobacteria,2YUFM@29|Myxococcales	28221|Deltaproteobacteria	M	Belongs to the mandelate racemase muconate lactonizing enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	MR_MLE_C,MR_MLE_N
HKD2_k127_1575581_0	485913.Krac_5561	3.32e-293	908.0	COG0028@1|root,COG0028@2|Bacteria,2G5Q7@200795|Chloroflexi	2|Bacteria	H	Thiamine pyrophosphate protein TPP binding domain protein	spxB	-	1.2.3.3,1.2.5.1	ko:K00156,ko:K00158	ko00620,ko01100,map00620,map01100	-	R00207,R03145	RC00860,RC02745	ko00000,ko00001,ko01000	-	-	iSB619.SA_RS13340	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
HKD2_k127_1575581_1	632335.Calkr_0253	8.184e-54	196.0	COG0745@1|root,COG0745@2|Bacteria,1TS81@1239|Firmicutes,248XH@186801|Clostridia,42EYI@68295|Thermoanaerobacterales	186801|Clostridia	K	Response regulator receiver	-	-	-	ko:K07669	ko02020,map02020	M00460	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
HKD2_k127_157889_0	1382306.JNIM01000001_gene2926	8.137e-270	843.0	COG0388@1|root,COG0388@2|Bacteria,2G75S@200795|Chloroflexi	200795|Chloroflexi	S	Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase	-	-	3.5.1.53	ko:K12251	ko00330,ko01100,map00330,map01100	-	R01152	RC00096	ko00000,ko00001,ko01000	-	-	-	CN_hydrolase
HKD2_k127_1589999_1	485913.Krac_8711	7.484e-49	177.0	COG0745@1|root,COG0745@2|Bacteria	485913.Krac_8711|-	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1589999_0	485913.Krac_8709	1.094e-113	368.0	COG0605@1|root,COG0605@2|Bacteria,2G5Q9@200795|Chloroflexi	200795|Chloroflexi	C	Destroys radicals which are normally produced within the cells and which are toxic to biological systems	sod	-	1.15.1.1	ko:K04564	ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016	-	-	-	ko00000,ko00001,ko01000	-	-	-	Sod_Fe_C,Sod_Fe_N
HKD2_k127_1591560_0	485913.Krac_11786	1.029e-129	419.0	COG0249@1|root,COG0249@2|Bacteria,2G8CJ@200795|Chloroflexi	200795|Chloroflexi	L	PFAM DNA mismatch repair protein MutS domain protein	-	-	-	-	-	-	-	-	-	-	-	-	MutS_V
HKD2_k127_1591560_1	485913.Krac_11785	1.499e-80	280.0	COG2912@1|root,COG2912@2|Bacteria,2G72K@200795|Chloroflexi	200795|Chloroflexi	S	Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	TPR_9,Transglut_core2
HKD2_k127_1591560_2	485913.Krac_9911	7.753e-34	138.0	COG4409@1|root,COG4409@2|Bacteria	2|Bacteria	G	exo-alpha-(2->6)-sialidase activity	-	-	-	-	-	-	-	-	-	-	-	-	BNR_2,Gram_pos_anchor
HKD2_k127_1620869_0	485913.Krac_12015	3.783e-156	497.0	COG0183@1|root,COG0183@2|Bacteria,2G66E@200795|Chloroflexi	200795|Chloroflexi	I	Belongs to the thiolase family	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
HKD2_k127_1620869_1	485913.Krac_12017	8.062e-77	260.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD2_k127_1643529_0	485913.Krac_7802	2.705e-101	340.0	COG4745@1|root,COG4745@2|Bacteria,2G6HI@200795|Chloroflexi	200795|Chloroflexi	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HKD2_k127_164698_0	485913.Krac_8398	7.963e-126	410.0	COG0654@1|root,COG0654@2|Bacteria	2|Bacteria	CH	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases	MA20_30655	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3
HKD2_k127_164698_1	485913.Krac_8401	3.125e-63	222.0	COG1309@1|root,COG1309@2|Bacteria,2G72N@200795|Chloroflexi	200795|Chloroflexi	K	PFAM regulatory protein TetR	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_7,TetR_N
HKD2_k127_1646998_0	485913.Krac_8516	1.167e-72	252.0	COG2898@1|root,COG2898@2|Bacteria,2G6KJ@200795|Chloroflexi	200795|Chloroflexi	S	conserved protein (DUF2156)	-	-	2.3.2.3	ko:K14205	ko01503,ko02020,ko05150,map01503,map02020,map05150	M00726	-	-	ko00000,ko00001,ko00002,ko01000,ko01504	2.A.1.3.37	-	-	DUF2156,LPG_synthase_TM
HKD2_k127_1648779_0	485913.Krac_12154	1.856e-286	890.0	COG1132@1|root,COG1132@2|Bacteria,2G5P7@200795|Chloroflexi	200795|Chloroflexi	V	PFAM ABC transporter related	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
HKD2_k127_1682362_0	1382306.JNIM01000001_gene295	5.355e-90	304.0	COG0642@1|root,COG2205@2|Bacteria	1382306.JNIM01000001_gene295|-	T	PhoQ Sensor	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1682362_2	1382306.JNIM01000001_gene294	5.827e-39	151.0	29684@1|root,2ZTI4@2|Bacteria,2G9NR@200795|Chloroflexi	200795|Chloroflexi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1682362_1	485913.Krac_12579	2.333e-48	184.0	COG1388@1|root,COG3942@1|root,COG1388@2|Bacteria,COG3942@2|Bacteria	2|Bacteria	S	pathogenesis	safA	-	3.5.1.104	ko:K21471,ko:K22278	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	CAP,CHAP,LysM
HKD2_k127_1704735_1	485913.Krac_6350	1.784e-119	391.0	COG3648@1|root,COG3648@2|Bacteria,2G7WX@200795|Chloroflexi	200795|Chloroflexi	Q	Uricase	-	-	-	-	-	-	-	-	-	-	-	-	Uricase
HKD2_k127_1704735_0	1382356.JQMP01000001_gene751	1.82e-168	542.0	COG1319@1|root,COG2080@1|root,COG1319@2|Bacteria,COG2080@2|Bacteria,2G5XD@200795|Chloroflexi	200795|Chloroflexi	C	CO dehydrogenase flavoprotein C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	CO_deh_flav_C,FAD_binding_5,Fer2,Fer2_2
HKD2_k127_1728292_0	383372.Rcas_3097	9.197e-33	143.0	COG0297@1|root,COG0297@2|Bacteria,2GBMD@200795|Chloroflexi,37794@32061|Chloroflexia	32061|Chloroflexia	H	PFAM glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
HKD2_k127_1728292_1	697281.Mahau_2343	1.749e-23	117.0	COG0728@1|root,COG0728@2|Bacteria,1TPFI@1239|Firmicutes,247N3@186801|Clostridia,42EMB@68295|Thermoanaerobacterales	186801|Clostridia	S	Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane	murJ	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
HKD2_k127_1734175_2	485913.Krac_3996	1.378e-25	109.0	COG3464@1|root,COG3464@2|Bacteria,2G9TP@200795|Chloroflexi	200795|Chloroflexi	L	PFAM transposase IS204 IS1001 IS1096 IS1165 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_ISL3,zf-ISL3
HKD2_k127_1734175_1	43989.cce_5192	6.349e-32	127.0	COG2963@1|root,COG2963@2|Bacteria,1GAAT@1117|Cyanobacteria	1117|Cyanobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Tnp_1
HKD2_k127_1734175_0	118173.KB235910_gene4646	7.394e-107	353.0	COG2801@1|root,COG2801@2|Bacteria,1G5GD@1117|Cyanobacteria,1HGQD@1150|Oscillatoriales	1117|Cyanobacteria	L	PFAM Integrase core domain	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,HTH_Tnp_1,rve
HKD2_k127_1737365_2	479434.Sthe_1630	2.781e-63	230.0	COG0449@1|root,COG0449@2|Bacteria	2|Bacteria	M	glutamine-fructose-6-phosphate transaminase (isomerizing) activity	-	-	2.6.1.16,5.3.1.8,5.3.1.9	ko:K00820,ko:K15916	ko00010,ko00030,ko00051,ko00250,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,ko04931,map00010,map00030,map00051,map00250,map00500,map00520,map01100,map01110,map01120,map01130,map01200,map04931	M00001,M00004,M00114	R00768,R01819,R02739,R02740,R03321	RC00010,RC00163,RC00376,RC00563,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	SIS
HKD2_k127_1737365_0	1382306.JNIM01000001_gene1142	1.83e-132	444.0	COG0515@1|root,COG0515@2|Bacteria	1382306.JNIM01000001_gene1142|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1737365_1	1382306.JNIM01000001_gene1141	4.437e-115	376.0	COG4198@1|root,COG4198@2|Bacteria,2G6FC@200795|Chloroflexi	200795|Chloroflexi	S	Protein of unknown function (DUF1015)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1015
HKD2_k127_1755310_1	1038860.AXAP01000029_gene682	3.436e-31	123.0	COG1023@1|root,COG1023@2|Bacteria,1QU14@1224|Proteobacteria,2TT6S@28211|Alphaproteobacteria,3JTRY@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	6-phosphogluconate dehydrogenase, C-terminal domain	gnd	-	1.1.1.343,1.1.1.44	ko:K00033	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200	M00004,M00006	R01528,R10221	RC00001,RC00539	ko00000,ko00001,ko00002,ko01000	-	-	-	6PGD,NAD_binding_2
HKD2_k127_1755310_0	1382306.JNIM01000001_gene4017	3.503e-77	277.0	COG4934@1|root,COG4934@2|Bacteria	2|Bacteria	O	collagen metabolic process	-	-	-	ko:K08677	-	-	-	-	ko00000,ko01002	-	-	-	Peptidase_S8
HKD2_k127_1767326_1	1382306.JNIM01000001_gene459	8.134e-156	497.0	COG1052@1|root,COG1052@2|Bacteria,2G5K0@200795|Chloroflexi	200795|Chloroflexi	C	D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding	-	-	1.1.1.26	ko:K00015	ko00630,ko01100,ko01110,ko01120,map00630,map01100,map01110,map01120	-	R00717,R01388	RC00031,RC00042	ko00000,ko00001,ko01000	-	-	-	2-Hacid_dh,2-Hacid_dh_C
HKD2_k127_1767326_2	485913.Krac_11985	2.293e-122	397.0	COG1215@1|root,COG1215@2|Bacteria,2G6BS@200795|Chloroflexi	200795|Chloroflexi	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HKD2_k127_1767326_0	485913.Krac_11974	5.47e-172	551.0	COG0484@1|root,COG0484@2|Bacteria	2|Bacteria	O	heat shock protein binding	-	-	-	-	-	-	-	-	-	-	-	-	DnaJ
HKD2_k127_1767326_3	1382306.JNIM01000001_gene462	1.467e-74	256.0	COG0122@1|root,COG0122@2|Bacteria,2G8TI@200795|Chloroflexi	200795|Chloroflexi	K	endonuclease III	-	-	3.2.2.21	ko:K01247	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
HKD2_k127_1767574_0	485913.Krac_10473	1.832e-126	413.0	COG1120@1|root,COG1120@2|Bacteria,2G6QS@200795|Chloroflexi	200795|Chloroflexi	P	PFAM ABC transporter related	fepC	-	3.6.3.34	ko:K02013	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14	-	-	ABC_tran
HKD2_k127_1767574_1	485913.Krac_10472	4.068e-26	111.0	COG1977@1|root,COG1977@2|Bacteria	2|Bacteria	H	Mo-molybdopterin cofactor metabolic process	-	-	-	ko:K03636	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
HKD2_k127_177031_2	671143.DAMO_2167	8.07e-16	79.0	COG0464@1|root,COG0464@2|Bacteria,2NR2V@2323|unclassified Bacteria	2|Bacteria	O	AAA domain (dynein-related subfamily)	cbbX	-	-	-	-	-	-	-	-	-	-	-	AAA
HKD2_k127_177031_1	1051632.TPY_0781	3.99e-63	219.0	COG4451@1|root,COG4451@2|Bacteria,1VVRB@1239|Firmicutes	1239|Firmicutes	C	Ribulose bisphosphate carboxylase, small chain	-	-	4.1.1.39	ko:K01602	ko00630,ko00710,ko01100,ko01120,ko01200,map00630,map00710,map01100,map01120,map01200	M00165,M00166,M00532	R00024,R03140	RC00172,RC00859	ko00000,ko00001,ko00002,ko01000	-	-	-	RuBisCO_small
HKD2_k127_177031_0	1051632.TPY_0782	1.804e-278	859.0	COG1850@1|root,COG1850@2|Bacteria,1TSZQ@1239|Firmicutes,2482N@186801|Clostridia	186801|Clostridia	G	Belongs to the RuBisCO large chain family	-	-	4.1.1.39	ko:K01601	ko00630,ko00710,ko01100,ko01120,ko01200,map00630,map00710,map01100,map01120,map01200	M00165,M00166,M00532	R00024,R03140	RC00172,RC00859	ko00000,ko00001,ko00002,ko01000	-	-	-	RuBisCO_large,RuBisCO_large_N
HKD2_k127_1774824_0	743719.PaelaDRAFT_3775	2.131e-19	95.0	COG2909@1|root,COG2909@2|Bacteria,1UIMV@1239|Firmicutes,4HD7H@91061|Bacilli,26QDM@186822|Paenibacillaceae	91061|Bacilli	K	helix_turn_helix, Lux Regulon	-	-	-	ko:K03556	-	-	-	-	ko00000,ko03000	-	-	-	GerE
HKD2_k127_1774824_1	1385520.N802_06780	7.274e-08	57.0	COG1670@1|root,COG1670@2|Bacteria,2IIYT@201174|Actinobacteria,4FGR2@85021|Intrasporangiaceae	201174|Actinobacteria	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
HKD2_k127_1776489_0	485913.Krac_8552	8.269e-87	291.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD2_k127_1777333_0	383372.Rcas_0105	1.091e-142	461.0	COG3243@1|root,COG3243@2|Bacteria,2GBDM@200795|Chloroflexi,376J0@32061|Chloroflexia	32061|Chloroflexia	I	PFAM alpha beta hydrolase fold	-	-	-	ko:K03821	ko00650,map00650	-	R04254	RC00004	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1
HKD2_k127_1777333_2	765420.OSCT_0098	1.548e-21	100.0	2DSEU@1|root,33FV9@2|Bacteria,2GB80@200795|Chloroflexi,377IX@32061|Chloroflexia	32061|Chloroflexia	S	polyhydroxyalkanoic acid synthase, PhaR subunit	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1777333_1	485913.Krac_7240	4.786e-46	179.0	COG0589@1|root,COG0589@2|Bacteria,2G768@200795|Chloroflexi	200795|Chloroflexi	T	Belongs to the universal stress protein A family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD2_k127_1778632_0	1382306.JNIM01000001_gene893	8.678e-46	172.0	COG3944@1|root,COG3944@2|Bacteria,2G7A7@200795|Chloroflexi	200795|Chloroflexi	M	Lipopolysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	Wzz
HKD2_k127_1778632_1	485913.Krac_7830	1.436e-45	167.0	COG0438@1|root,COG0438@2|Bacteria,2G683@200795|Chloroflexi	200795|Chloroflexi	M	PFAM glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
HKD2_k127_1809941_2	485913.Krac_8941	1.318e-46	170.0	COG0640@1|root,COG0640@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	-	-	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	DUF2087,HTH_20,HTH_5
HKD2_k127_1809941_0	485913.Krac_8940	4.955e-123	400.0	COG0613@1|root,COG0613@2|Bacteria,2G74N@200795|Chloroflexi	200795|Chloroflexi	S	SMART phosphoesterase PHP domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PHP,PHP_C
HKD2_k127_1809941_1	485913.Krac_8939	4.206e-95	317.0	COG0558@1|root,COG0558@2|Bacteria,2G6RT@200795|Chloroflexi	200795|Chloroflexi	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	-	-	2.7.8.5	ko:K00995	ko00564,ko01100,map00564,map01100	-	R01801	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
HKD2_k127_1826707_1	485913.Krac_11073	2.092e-129	416.0	COG0749@1|root,COG0749@2|Bacteria,2G5J0@200795|Chloroflexi	200795|Chloroflexi	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	GO:0003674,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901362,GO:1901576	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
HKD2_k127_1826707_0	1382306.JNIM01000001_gene1219	1.981e-190	600.0	COG0436@1|root,COG0436@2|Bacteria,2G60K@200795|Chloroflexi	200795|Chloroflexi	E	Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate	dapL	-	2.6.1.83	ko:K10206	ko00300,ko01100,ko01110,ko01130,ko01230,map00300,map01100,map01110,map01130,map01230	M00527	R07613	RC00006,RC01847	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
HKD2_k127_1826707_2	485913.Krac_11064	8.697e-75	256.0	COG3408@1|root,COG3408@2|Bacteria,2G8AA@200795|Chloroflexi	200795|Chloroflexi	G	Glycogen debranching enzyme N terminal	-	-	-	-	-	-	-	-	-	-	-	-	GDE_C,GDE_N
HKD2_k127_1846144_1	1150469.RSPPHO_01133	4.659e-29	119.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2TR3P@28211|Alphaproteobacteria,2JRE7@204441|Rhodospirillales	204441|Rhodospirillales	I	COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
HKD2_k127_1852581_1	485913.Krac_9033	1.832e-100	330.0	COG0664@1|root,COG0664@2|Bacteria,2G63K@200795|Chloroflexi	200795|Chloroflexi	T	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1852581_0	485913.Krac_1239	1.949e-279	872.0	COG1142@1|root,COG2905@1|root,COG1142@2|Bacteria,COG2905@2|Bacteria	2|Bacteria	T	signal-transduction protein containing cAMP-binding and CBS domains	ccpN	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	CBS,Fer4_7,GAF,GGDEF,HATPase_c,HTH_11,HisKA,PAS_3,PAS_4,PAS_9,Pyr_redox_2,Pyr_redox_3,Response_reg,cNMP_binding
HKD2_k127_1853015_2	1125700.HMPREF9195_01003	4.289e-09	63.0	COG4942@1|root,COG4942@2|Bacteria,2J7BB@203691|Spirochaetes	203691|Spirochaetes	D	Protein of unknown function (DUF3375)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3375
HKD2_k127_1853015_1	1173264.KI913949_gene3087	1.02e-36	148.0	2CB46@1|root,31GHU@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF4194)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4194
HKD2_k127_1853015_0	497965.Cyan7822_1788	3.614e-78	271.0	COG4913@1|root,COG4913@2|Bacteria	2|Bacteria	D	Putative exonuclease SbcCD, C subunit	-	-	-	-	-	-	-	-	-	-	-	-	AAA_29,SbcCD_C
HKD2_k127_1861703_2	485913.Krac_7775	3.232e-74	252.0	COG0743@1|root,COG0743@2|Bacteria,2G5RB@200795|Chloroflexi	200795|Chloroflexi	I	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)	dxr	-	1.1.1.267	ko:K00099	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05688	RC01452	ko00000,ko00001,ko00002,ko01000	-	-	-	DXPR_C,DXP_redisom_C,DXP_reductoisom
HKD2_k127_1861703_1	485913.Krac_7776	3.166e-102	341.0	COG4589@1|root,COG4589@2|Bacteria,2G6QV@200795|Chloroflexi	200795|Chloroflexi	M	Belongs to the CDS family	cdsA	-	2.7.7.41	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_1
HKD2_k127_1861703_0	485913.Krac_7777	6.985e-133	427.0	COG0020@1|root,COG0020@2|Bacteria,2G65C@200795|Chloroflexi	200795|Chloroflexi	H	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids	uppS	-	2.5.1.31	ko:K00806	ko00900,ko01110,map00900,map01110	-	R06447	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
HKD2_k127_1869419_1	1382306.JNIM01000001_gene3460	9.942e-86	290.0	COG1008@1|root,COG1008@2|Bacteria,2G5VU@200795|Chloroflexi	200795|Chloroflexi	C	TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain M	-	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q5_N,Proton_antipo_M
HKD2_k127_1869419_0	485913.Krac_9053	5.085e-296	920.0	COG1009@1|root,COG1009@2|Bacteria,2G5NJ@200795|Chloroflexi	200795|Chloroflexi	CP	NADH-Ubiquinone oxidoreductase (complex I) chain 5 L domain protein	nuoL	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M,Proton_antipo_N
HKD2_k127_1869419_3	485913.Krac_9052	1.618e-41	154.0	COG0713@1|root,COG0713@2|Bacteria,2G6TP@200795|Chloroflexi	200795|Chloroflexi	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0050136,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204	1.6.5.3	ko:K00340	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q2
HKD2_k127_1869419_2	485913.Krac_9051	1.473e-48	177.0	COG0839@1|root,COG0839@2|Bacteria,2G78H@200795|Chloroflexi	200795|Chloroflexi	C	Belongs to the complex I subunit 6 family	-	-	1.6.5.3	ko:K00339	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q3
HKD2_k127_1902416_2	485913.Krac_0467	1.075e-124	405.0	COG0596@1|root,COG0596@2|Bacteria	2|Bacteria	S	hydrolase activity, acting on ester bonds	-	-	3.8.1.3	ko:K01561	ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120	-	R05287	RC00697	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1
HKD2_k127_1902416_1	485913.Krac_0469	3.551e-144	460.0	COG1250@1|root,COG1250@2|Bacteria,2G6EB@200795|Chloroflexi	200795|Chloroflexi	C	3-hydroxyacyl-CoA dehydrogenase domain protein	-	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
HKD2_k127_1902416_0	485913.Krac_1276	8.827e-181	567.0	COG2159@1|root,COG2159@2|Bacteria,2G8DN@200795|Chloroflexi	200795|Chloroflexi	S	Amidohydrolase	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
HKD2_k127_1902416_3	1382306.JNIM01000001_gene1940	2.282e-77	261.0	COG1472@1|root,COG1472@2|Bacteria	2|Bacteria	G	Belongs to the glycosyl hydrolase 3 family	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_3
HKD2_k127_1913922_2	485913.Krac_12028	2.554e-62	218.0	COG0642@1|root,COG2205@2|Bacteria,2GBNP@200795|Chloroflexi	200795|Chloroflexi	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_4
HKD2_k127_1913922_1	485913.Krac_12027	1.815e-109	358.0	COG1515@1|root,COG1515@2|Bacteria,2G6SS@200795|Chloroflexi	200795|Chloroflexi	L	DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA	nfi	-	3.1.21.7	ko:K05982	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	Endonuclease_5
HKD2_k127_1913922_0	485913.Krac_12026	1.426e-119	388.0	COG0500@1|root,COG2226@2|Bacteria,2G6N8@200795|Chloroflexi	200795|Chloroflexi	Q	Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
HKD2_k127_1921704_0	485913.Krac_8883	6.367e-123	407.0	COG0419@1|root,COG0419@2|Bacteria	2|Bacteria	L	ATPase involved in DNA repair	-	-	-	ko:K03546	-	-	-	-	ko00000,ko03400	-	-	-	AAA_15,AAA_23,Rad50_zn_hook,SMC_N
HKD2_k127_1928169_4	99598.Cal7507_4720	6.948e-08	54.0	COG1598@1|root,COG1598@2|Bacteria,1G8ZQ@1117|Cyanobacteria,1HPM5@1161|Nostocales	1117|Cyanobacteria	S	PFAM Uncharacterised protein family UPF0150	-	-	-	-	-	-	-	-	-	-	-	-	HicB_lk_antitox
HKD2_k127_1928169_0	886293.Sinac_0289	2.716e-59	210.0	COG3293@1|root,COG3293@2|Bacteria,2IY34@203682|Planctomycetes	203682|Planctomycetes	L	PFAM Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_2,DUF4096
HKD2_k127_1928169_1	604331.AUHY01000068_gene2275	1.822e-47	173.0	COG3293@1|root,COG3293@2|Bacteria	2|Bacteria	L	Transposase	-	-	-	ko:K07492	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DDE_Tnp_1_2,DUF4096
HKD2_k127_1928169_5	1125971.ASJB01000009_gene777	0.000328	53.0	COG1506@1|root,COG1506@2|Bacteria	2|Bacteria	E	serine-type peptidase activity	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	DLH,PD40,Peptidase_S9
HKD2_k127_1928169_2	1382306.JNIM01000001_gene1164	2.036e-24	102.0	COG1595@1|root,COG1595@2|Bacteria,2G6T5@200795|Chloroflexi	200795|Chloroflexi	K	PFAM sigma-70 region 2 domain protein	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD2_k127_1930723_0	485913.Krac_8192	8.072e-105	349.0	COG0524@1|root,COG0524@2|Bacteria,2G7CJ@200795|Chloroflexi	200795|Chloroflexi	G	pfkB family carbohydrate kinase	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
HKD2_k127_1930723_2	485913.Krac_8194	1.266e-52	187.0	COG2151@1|root,COG2151@2|Bacteria,2G75C@200795|Chloroflexi	200795|Chloroflexi	S	Pfam:DUF59	-	-	-	-	-	-	-	-	-	-	-	-	FeS_assembly_P
HKD2_k127_1931094_0	485913.Krac_7646	5.135e-150	484.0	COG0392@1|root,COG0392@2|Bacteria,2G6NX@200795|Chloroflexi	200795|Chloroflexi	S	PFAM conserved	-	-	-	ko:K07027	-	-	-	-	ko00000,ko02000	4.D.2	-	-	LPG_synthase_TM
HKD2_k127_1931094_1	485913.Krac_7645	2.048e-13	71.0	COG3307@1|root,COG3307@2|Bacteria,2G6TE@200795|Chloroflexi	200795|Chloroflexi	M	PFAM O-antigen polymerase	-	-	-	-	-	-	-	-	-	-	-	-	Wzy_C
HKD2_k127_1935138_1	485913.Krac_7851	2.852e-101	340.0	COG0406@1|root,COG0406@2|Bacteria,2G73Q@200795|Chloroflexi	200795|Chloroflexi	G	PFAM Phosphoglycerate mutase	-	-	-	-	-	-	-	-	-	-	-	-	His_Phos_1
HKD2_k127_1935138_0	1382306.JNIM01000001_gene901	4.135e-134	432.0	COG0630@1|root,COG0630@2|Bacteria,2G943@200795|Chloroflexi	200795|Chloroflexi	NU	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1935138_2	485913.Krac_7849	4.052e-08	54.0	COG0438@1|root,COG0438@2|Bacteria,2G5KS@200795|Chloroflexi	200795|Chloroflexi	M	PFAM glycosyl transferase group 1	-	-	2.4.1.250	ko:K15521	-	-	-	-	ko00000,ko01000	-	-	-	Glyco_transf_4,Glycos_transf_1
HKD2_k127_1944239_1	1382306.JNIM01000001_gene3282	1.932e-92	308.0	COG0277@1|root,COG0277@2|Bacteria,2G7TD@200795|Chloroflexi	200795|Chloroflexi	C	D-arabinono-1,4-lactone oxidase	-	-	-	-	-	-	-	-	-	-	-	-	ALO,FAD_binding_4
HKD2_k127_1944239_0	1382306.JNIM01000001_gene3281	1.436e-181	576.0	COG3616@1|root,COG3616@2|Bacteria	2|Bacteria	E	Alanine racemase, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Ala_racemase_N
HKD2_k127_1945090_2	485913.Krac_9968	2.441e-108	353.0	COG0124@1|root,COG0124@2|Bacteria,2G6CX@200795|Chloroflexi	200795|Chloroflexi	J	PFAM tRNA synthetase class II (G H P and S)	hisZ	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
HKD2_k127_1945090_1	1382306.JNIM01000001_gene1888	2.814e-148	473.0	COG0548@1|root,COG0548@2|Bacteria,2G6ZG@200795|Chloroflexi	200795|Chloroflexi	F	Belongs to the acetylglutamate kinase family. ArgB subfamily	argB	GO:0003674,GO:0003824,GO:0003991,GO:0005488,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0019752,GO:0031406,GO:0034618,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.2.8	ko:K00930	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R02649	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase
HKD2_k127_1945090_0	485913.Krac_9402	1.024e-149	481.0	COG0002@1|root,COG0002@2|Bacteria,2G6D0@200795|Chloroflexi	200795|Chloroflexi	E	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde	argC	-	1.2.1.38	ko:K00145	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R03443	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
HKD2_k127_1945090_3	1382306.JNIM01000001_gene938	4.469e-44	164.0	COG1304@1|root,COG1304@2|Bacteria,2G8E7@200795|Chloroflexi	200795|Chloroflexi	C	PFAM FMN-dependent alpha-hydroxy acid dehydrogenase	-	-	1.1.2.3,1.1.3.46	ko:K00101,ko:K16422	ko00261,ko00620,ko01055,ko01100,ko01130,map00261,map00620,map01055,map01100,map01130	-	R00196,R06633	RC00044,RC00240	ko00000,ko00001,ko01000	-	-	-	FMN_dh
HKD2_k127_1968191_0	1382306.JNIM01000001_gene145	5.847e-249	779.0	COG0744@1|root,COG0744@2|Bacteria,2G5ZG@200795|Chloroflexi	200795|Chloroflexi	M	PFAM glycosyl transferase, family 51	-	-	-	-	-	-	-	-	-	-	-	-	Transpeptidase
HKD2_k127_1972612_0	485913.Krac_10995	1.343e-187	592.0	COG0119@1|root,COG0119@2|Bacteria,2G5V9@200795|Chloroflexi	200795|Chloroflexi	H	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)	-	-	-	-	-	-	-	-	-	-	-	-	HMGL-like
HKD2_k127_1972612_1	1382306.JNIM01000001_gene1243	8.578e-60	208.0	COG0059@1|root,COG0059@2|Bacteria,2G5NP@200795|Chloroflexi	200795|Chloroflexi	H	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate	ilvC	-	1.1.1.86	ko:K00053	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R03051,R04439,R04440,R05068,R05069,R05071	RC00726,RC00836,RC00837,RC01726	ko00000,ko00001,ko00002,ko01000	-	-	-	IlvC,IlvN
HKD2_k127_197437_1	485913.Krac_2692	3.095e-46	179.0	COG1484@1|root,COG1484@2|Bacteria	2|Bacteria	L	DNA-dependent DNA replication	-	-	-	ko:K02315	-	-	-	-	ko00000,ko03032	-	-	-	IstB_IS21
HKD2_k127_197437_0	485913.Krac_12128	6.671e-176	562.0	COG0305@1|root,COG0305@2|Bacteria,2G64D@200795|Chloroflexi	200795|Chloroflexi	L	Participates in initiation and elongation during chromosome replication	dnaB	-	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C
HKD2_k127_1984594_1	379066.GAU_3440	6.658e-62	230.0	COG3497@1|root,COG3497@2|Bacteria	2|Bacteria	S	Phage tail sheath protein subtilisin-like domain	-	-	-	ko:K06907	-	-	-	-	ko00000	-	-	-	Phage_sheath_1,Phage_sheath_1C
HKD2_k127_1984594_2	1449048.JQKU01000001_gene1947	5.997e-50	181.0	2CCBI@1|root,32RVA@2|Bacteria,2IFX8@201174|Actinobacteria,239E5@1762|Mycobacteriaceae	201174|Actinobacteria	S	T4-like virus tail tube protein gp19	-	-	-	-	-	-	-	-	-	-	-	-	Phage_T4_gp19
HKD2_k127_1984594_0	388051.AUFE01000002_gene394	4.328e-78	264.0	COG3497@1|root,COG3497@2|Bacteria,1MX89@1224|Proteobacteria,2VM4U@28216|Betaproteobacteria,1K9P6@119060|Burkholderiaceae	28216|Betaproteobacteria	S	COG Phage tail sheath protein FI	-	-	-	ko:K06907	-	-	-	-	ko00000	-	-	-	Phage_sheath_1,Phage_sheath_1C
HKD2_k127_199697_0	1382306.JNIM01000001_gene1140	2.93e-108	356.0	COG0388@1|root,COG0388@2|Bacteria,2G6KM@200795|Chloroflexi	200795|Chloroflexi	S	PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase	-	-	3.5.1.53	ko:K11206,ko:K12251	ko00330,ko01100,map00330,map01100	-	R01152	RC00096	ko00000,ko00001,ko01000	-	-	-	CN_hydrolase
HKD2_k127_199697_1	1459636.NTE_01156	3.126e-60	213.0	COG0783@1|root,arCOG01101@2157|Archaea	2157|Archaea	P	Belongs to the Dps family	frt	-	-	ko:K04047	-	-	-	-	ko00000,ko03036	-	-	-	Ferritin
HKD2_k127_2001920_2	485913.Krac_10001	2.764e-48	177.0	COG1371@1|root,COG1371@2|Bacteria,2G7BQ@200795|Chloroflexi	200795|Chloroflexi	S	Archease protein family (MTH1598/TM1083)	-	-	-	-	-	-	-	-	-	-	-	-	Archease
HKD2_k127_2001920_0	485913.Krac_9998	8.744e-253	786.0	COG1690@1|root,COG1690@2|Bacteria,2G5NT@200795|Chloroflexi	200795|Chloroflexi	S	Belongs to the RtcB family	rtcB	-	6.5.1.3	ko:K14415	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RtcB
HKD2_k127_2001920_1	1382306.JNIM01000001_gene3592	8.874e-152	486.0	COG1294@1|root,COG1294@2|Bacteria,2G67G@200795|Chloroflexi	200795|Chloroflexi	C	PFAM cytochrome bd ubiquinol oxidase subunit II	-	-	1.10.3.14	ko:K00426	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	Cyt_bd_oxida_II
HKD2_k127_2006665_1	1356854.N007_12945	4.932e-15	81.0	COG1595@1|root,COG1595@2|Bacteria,1VBAM@1239|Firmicutes,4HMAY@91061|Bacilli	91061|Bacilli	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD2_k127_2010846_2	485913.Krac_8734	4.485e-28	113.0	COG0596@1|root,COG0596@2|Bacteria,2GA70@200795|Chloroflexi	200795|Chloroflexi	S	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
HKD2_k127_2010846_0	266117.Rxyl_1989	9.806e-73	255.0	COG0395@1|root,COG0395@2|Bacteria,2GKEE@201174|Actinobacteria,4CPZI@84995|Rubrobacteria	84995|Rubrobacteria	G	binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
HKD2_k127_2010846_1	670487.Ocepr_0506	3.26e-67	240.0	COG1175@1|root,COG1175@2|Bacteria,1WI9Z@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	G	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K10237	ko02010,map02010	M00204	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.17	-	-	BPD_transp_1
HKD2_k127_2011555_1	485913.Krac_8688	3.771e-73	252.0	COG0438@1|root,COG0438@2|Bacteria,2G8P6@200795|Chloroflexi	200795|Chloroflexi	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
HKD2_k127_2011555_0	485913.Krac_8688	2.44e-111	361.0	COG0438@1|root,COG0438@2|Bacteria,2G8P6@200795|Chloroflexi	200795|Chloroflexi	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
HKD2_k127_2022589_0	903814.ELI_1455	1.322e-108	359.0	arCOG04460@1|root,2ZABX@2|Bacteria,1VR6H@1239|Firmicutes,24XV6@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2023960_1	497964.CfE428DRAFT_4044	1.525e-41	172.0	COG2303@1|root,COG2303@2|Bacteria	2|Bacteria	E	choline dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	DAO,GMC_oxred_C,GMC_oxred_N,NAD_binding_8,Pyr_redox_2
HKD2_k127_2023960_0	485913.Krac_2415	2.797e-105	361.0	COG1216@1|root,COG1216@2|Bacteria,2G8VQ@200795|Chloroflexi	200795|Chloroflexi	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HKD2_k127_2026263_0	485913.Krac_6050	6.301e-120	388.0	COG3316@1|root,COG3316@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K18320	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS240
HKD2_k127_2030811_0	485913.Krac_11076	1.752e-95	323.0	COG1087@1|root,COG1087@2|Bacteria,2GA96@200795|Chloroflexi	200795|Chloroflexi	M	3-beta hydroxysteroid dehydrogenase/isomerase family	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
HKD2_k127_2030811_1	485913.Krac_11079	3.667e-16	78.0	COG1109@1|root,COG1208@1|root,COG1109@2|Bacteria,COG1208@2|Bacteria,2G65W@200795|Chloroflexi	200795|Chloroflexi	M	PFAM transferase hexapeptide repeat containing protein	-	-	2.7.7.13,5.4.2.8	ko:K16881	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114,M00362	R00885,R01818	RC00002,RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase,PGM_PMM_I,PGM_PMM_II,PGM_PMM_III
HKD2_k127_2036234_0	485913.Krac_10287	2.278e-20	92.0	COG0277@1|root,COG0277@2|Bacteria,2G5TM@200795|Chloroflexi	200795|Chloroflexi	C	PFAM FAD linked oxidase domain protein	-	-	1.1.2.4,1.1.3.15	ko:K00102,ko:K00104	ko00620,ko00630,ko01100,ko01110,ko01120,ko01130,map00620,map00630,map01100,map01110,map01120,map01130	-	R00197,R00475	RC00042,RC00044	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
HKD2_k127_2039396_1	485913.Krac_8702	2.643e-11	64.0	COG3464@1|root,COG3464@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	UPF0236
HKD2_k127_2039396_0	485913.Krac_12332	1.643e-164	522.0	COG0515@1|root,COG0515@2|Bacteria,2G67H@200795|Chloroflexi	200795|Chloroflexi	KLT	SMART serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HKD2_k127_2048268_1	485913.Krac_11106	3.125e-110	362.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD2_k127_2048768_1	485913.Krac_8338	2.504e-27	111.0	COG0571@1|root,COG0571@2|Bacteria,2G6PD@200795|Chloroflexi	200795|Chloroflexi	J	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism	-	-	-	-	-	-	-	-	-	-	-	-	Ribonucleas_3_3,dsrm
HKD2_k127_2048768_0	1382306.JNIM01000001_gene375	3.904e-62	224.0	COG1276@1|root,COG2372@1|root,COG1276@2|Bacteria,COG2372@2|Bacteria,2G8KM@200795|Chloroflexi	200795|Chloroflexi	P	PFAM copper resistance protein CopC	-	-	-	ko:K14166	-	-	-	-	ko00000,ko02000	-	-	-	CopC,CopD
HKD2_k127_2053708_0	1382306.JNIM01000001_gene281	2.372e-187	588.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	rfaG	GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008194,GO:0008610,GO:0008653,GO:0008919,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0035251,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0046401,GO:0046527,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	-	ko:K02844	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT4	iSDY_1059.SDY_4061	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
HKD2_k127_2057874_3	1382306.JNIM01000001_gene3738	2.353e-59	212.0	COG0711@1|root,COG0711@2|Bacteria,2G79J@200795|Chloroflexi	200795|Chloroflexi	C	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2057874_1	485913.Krac_8242	1.788e-81	276.0	COG1399@1|root,COG1399@2|Bacteria,2G6Z5@200795|Chloroflexi	200795|Chloroflexi	S	Uncharacterized ACR, COG1399	-	-	-	ko:K07040	-	-	-	-	ko00000	-	-	-	DUF177
HKD2_k127_2057874_6	485913.Krac_8243	7.515e-27	110.0	COG0333@1|root,COG0333@2|Bacteria,2G7EA@200795|Chloroflexi	200795|Chloroflexi	J	Belongs to the bacterial ribosomal protein bL32 family	rpmF	-	-	ko:K02911	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_L32p
HKD2_k127_2057874_0	485913.Krac_8244	2.743e-129	421.0	COG0331@1|root,COG0331@2|Bacteria,2G61W@200795|Chloroflexi	200795|Chloroflexi	I	malonyl CoA-acyl carrier protein transacylase	fabD	-	2.3.1.39	ko:K00645	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	M00082	R01626,R11671	RC00004,RC00039,RC02727	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyl_transf_1
HKD2_k127_2057874_4	1382306.JNIM01000001_gene3741	2.069e-38	147.0	COG1302@1|root,COG1302@2|Bacteria,2G7GB@200795|Chloroflexi	200795|Chloroflexi	S	Asp23 family, cell envelope-related function	-	-	-	-	-	-	-	-	-	-	-	-	Asp23
HKD2_k127_2057874_2	485913.Krac_8246	1.071e-76	258.0	COG0781@1|root,COG0781@2|Bacteria,2G6XA@200795|Chloroflexi	200795|Chloroflexi	K	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons	nusB	-	-	ko:K03625	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	NusB
HKD2_k127_2057874_5	485913.Krac_8247	1.237e-33	130.0	COG0236@1|root,COG0236@2|Bacteria,2G76M@200795|Chloroflexi	200795|Chloroflexi	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	acpP	GO:0000035,GO:0000036,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016053,GO:0019637,GO:0019752,GO:0019842,GO:0031177,GO:0032787,GO:0033218,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044620,GO:0046394,GO:0046467,GO:0046493,GO:0048037,GO:0051192,GO:0071704,GO:0072330,GO:0072341,GO:0090407,GO:0140104,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
HKD2_k127_206196_1	485913.Krac_11184	3.551e-89	299.0	COG0424@1|root,COG0424@2|Bacteria,2G6U2@200795|Chloroflexi	200795|Chloroflexi	D	PFAM Maf family protein	maf	-	-	ko:K06287	-	-	-	-	ko00000	-	-	-	Maf
HKD2_k127_206196_0	292459.STH2668	1.844e-101	341.0	COG0008@1|root,COG0008@2|Bacteria,1TVW7@1239|Firmicutes,24BG2@186801|Clostridia	186801|Clostridia	J	Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon	gluQ	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
HKD2_k127_206196_2	1382306.JNIM01000001_gene685	1.92e-59	215.0	COG0668@1|root,COG0668@2|Bacteria,2G754@200795|Chloroflexi	200795|Chloroflexi	M	Mechanosensitive ion channel	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel
HKD2_k127_2066130_0	485913.Krac_8282	4.838e-162	518.0	COG1009@1|root,COG1009@2|Bacteria,2G5NJ@200795|Chloroflexi	200795|Chloroflexi	CP	NADH-Ubiquinone oxidoreductase (complex I) chain 5 L domain protein	-	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M,Proton_antipo_N
HKD2_k127_2076952_0	1382306.JNIM01000001_gene549	6.976e-127	409.0	COG1023@1|root,COG1023@2|Bacteria,2G5YD@200795|Chloroflexi	200795|Chloroflexi	G	TIGRFAM 6-phosphogluconate dehydrogenase (decarboxylating)	-	-	1.1.1.343,1.1.1.44	ko:K00033	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200	M00004,M00006	R01528,R10221	RC00001,RC00539	ko00000,ko00001,ko00002,ko01000	-	-	-	6PGD,NAD_binding_2
HKD2_k127_2110432_3	485913.Krac_11124	1.467e-93	312.0	COG0601@1|root,COG0601@2|Bacteria,2G8C4@200795|Chloroflexi	2|Bacteria	P	COGs COG0601 ABC-type dipeptide oligopeptide nickel transport systems permease components	oppB	-	-	ko:K02033,ko:K13894	ko02010,ko02024,map02010,map02024	M00239,M00349	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.21,3.A.1.5.24	-	-	BPD_transp_1
HKD2_k127_2110432_2	485913.Krac_10946	5.111e-134	436.0	COG1173@1|root,COG1173@2|Bacteria,2G8N2@200795|Chloroflexi	2|Bacteria	EP	COGs COG1173 ABC-type dipeptide oligopeptide nickel transport systems permease components	-	-	-	ko:K02034,ko:K15582	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	BPD_transp_1,OppC_N
HKD2_k127_2110432_1	485913.Krac_10947	3.046e-179	565.0	COG0444@1|root,COG0444@2|Bacteria,2G5PT@200795|Chloroflexi	200795|Chloroflexi	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
HKD2_k127_2110432_0	485913.Krac_10948	1.097e-185	587.0	COG4608@1|root,COG4608@2|Bacteria,2G5R5@200795|Chloroflexi	200795|Chloroflexi	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02032,ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
HKD2_k127_2110727_0	485913.Krac_11959	3.514e-126	421.0	COG1305@1|root,COG1305@2|Bacteria,2G66M@200795|Chloroflexi	200795|Chloroflexi	E	PFAM transglutaminase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF4129,Transglut_core
HKD2_k127_2114698_1	485913.Krac_2257	2.347e-20	92.0	COG3677@1|root,COG3677@2|Bacteria	2|Bacteria	L	transposition, DNA-mediated	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS1,HTH_23,Zn_Tnp_IS1
HKD2_k127_2114698_0	485913.Krac_7298	1.904e-85	288.0	2EYJ4@1|root,33RSV@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2120011_5	485913.Krac_6227	2.32e-18	88.0	COG3316@1|root,COG3316@2|Bacteria,2G9P3@200795|Chloroflexi	200795|Chloroflexi	L	COGs COG3316 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS240
HKD2_k127_2120011_1	1382306.JNIM01000001_gene231	1.67e-178	560.0	COG1878@1|root,COG1878@2|Bacteria,2G8DE@200795|Chloroflexi	200795|Chloroflexi	S	Putative cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Cyclase
HKD2_k127_2120011_2	1449126.JQKL01000004_gene620	2.01e-160	516.0	COG0154@1|root,COG0154@2|Bacteria,1TP0C@1239|Firmicutes,24911@186801|Clostridia,2689E@186813|unclassified Clostridiales	186801|Clostridia	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	-	-	3.5.1.4	ko:K01426	ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120	-	R02540,R03096,R03180,R03909,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000	-	-	-	Amidase
HKD2_k127_2120011_3	1382306.JNIM01000001_gene1830	3.401e-120	394.0	COG1319@1|root,COG1319@2|Bacteria	2|Bacteria	C	xanthine dehydrogenase activity	-	-	1.2.5.3	ko:K03519	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
HKD2_k127_2120011_4	1382306.JNIM01000001_gene1831	1.03e-78	266.0	COG2080@1|root,COG2080@2|Bacteria	2|Bacteria	C	2 iron, 2 sulfur cluster binding	-	-	1.2.5.3,1.3.99.16	ko:K03518,ko:K07302	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Fer2,Fer2_2
HKD2_k127_2120011_0	1382306.JNIM01000001_gene1832	2.363e-248	772.0	COG1529@1|root,COG1529@2|Bacteria,2G608@200795|Chloroflexi	200795|Chloroflexi	C	aldehyde oxidase and xanthine dehydrogenase, a b hammerhead	-	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
HKD2_k127_213125_0	485913.Krac_5147	1.776e-71	251.0	COG2267@1|root,COG2267@2|Bacteria	2|Bacteria	I	carboxylic ester hydrolase activity	ycgS	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_4
HKD2_k127_2134027_1	448385.sce1014	1.94e-55	206.0	COG0642@1|root,COG2205@2|Bacteria	448385.sce1014|-	T	PhoQ Sensor	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2134027_0	1128421.JAGA01000002_gene842	7.646e-101	337.0	COG2223@1|root,COG2223@2|Bacteria	2|Bacteria	P	nitrite transmembrane transporter activity	nasA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K02575	ko00910,map00910	M00615	-	-	ko00000,ko00001,ko00002,ko02000	2.A.1.8	-	iYO844.BSU03330	MFS_1
HKD2_k127_2136932_0	1382306.JNIM01000001_gene3868	1.622e-124	404.0	COG1210@1|root,COG1210@2|Bacteria,2G6XV@200795|Chloroflexi	200795|Chloroflexi	M	PFAM Nucleotidyl transferase	-	-	2.7.7.9	ko:K00963	ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130	M00129,M00361,M00362,M00549	R00289	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
HKD2_k127_214298_1	485913.Krac_10606	2.684e-14	73.0	COG1233@1|root,COG1233@2|Bacteria,2G5ZA@200795|Chloroflexi	200795|Chloroflexi	C	PFAM amine oxidase	crtI	-	1.3.99.26,1.3.99.28,1.3.99.29,1.3.99.31	ko:K10027	ko00906,ko01100,ko01110,map00906,map01100,map01110	-	R04787,R04798,R04800,R09691,R09692	RC01214,RC02088,RC02605	ko00000,ko00001,ko01000	-	-	-	Amino_oxidase
HKD2_k127_214298_0	485913.Krac_10605	4.633e-134	436.0	COG1073@1|root,COG1073@2|Bacteria	485913.Krac_10605|-	S	thiolester hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2199112_1	383372.Rcas_2403	4.986e-66	231.0	COG0693@1|root,COG0693@2|Bacteria	2|Bacteria	S	protein deglycation	pfpI	-	3.5.1.124	ko:K05520	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	DJ-1_PfpI
HKD2_k127_2199112_0	485913.Krac_11199	0.0	1659.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,2G5Y6@200795|Chloroflexi	200795|Chloroflexi	H	Methionine synthase B12-binding module cap domain protein	-	-	2.1.1.13,2.1.1.258	ko:K00548,ko:K15023	ko00270,ko00450,ko00670,ko00720,ko01100,ko01110,ko01120,ko01200,ko01230,map00270,map00450,map00670,map00720,map01100,map01110,map01120,map01200,map01230	M00017,M00377	R00946,R02289,R09365,R10243	RC00004,RC00035,RC00113,RC01144,RC01241,RC02871,RC02977	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
HKD2_k127_2219384_0	485913.Krac_7381	1.478e-117	387.0	COG1230@1|root,COG1230@2|Bacteria,2G6FI@200795|Chloroflexi	200795|Chloroflexi	P	TIGRFAM cation diffusion facilitator family transporter	-	-	-	ko:K16264	-	-	-	-	ko00000,ko02000	2.A.4.1	-	-	Cation_efflux
HKD2_k127_2219384_1	1382306.JNIM01000001_gene2026	9.44e-49	179.0	COG0640@1|root,COG0640@2|Bacteria,2G78R@200795|Chloroflexi	200795|Chloroflexi	K	PFAM regulatory protein, ArsR	-	-	-	ko:K21903	-	-	-	-	ko00000,ko03000	-	-	-	HTH_5
HKD2_k127_2243687_3	485913.Krac_8291	8.823e-15	74.0	COG4274@1|root,COG4274@2|Bacteria,2G9EB@200795|Chloroflexi	200795|Chloroflexi	S	GYD domain	-	-	-	-	-	-	-	-	-	-	-	-	GYD
HKD2_k127_2243687_0	485913.Krac_8290	2.837e-160	511.0	COG0391@1|root,COG0391@2|Bacteria,2G5MJ@200795|Chloroflexi	200795|Chloroflexi	S	Required for morphogenesis under gluconeogenic growth conditions	-	-	-	-	-	-	-	-	-	-	-	-	UPF0052
HKD2_k127_2243687_1	485913.Krac_8287	1.115e-111	364.0	COG3387@1|root,COG3387@2|Bacteria	2|Bacteria	G	glucan 1,4-alpha-glucosidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_15
HKD2_k127_224392_0	485913.Krac_7748	2.01e-75	259.0	COG2802@1|root,COG2802@2|Bacteria,2G76N@200795|Chloroflexi	200795|Chloroflexi	S	PFAM peptidase S16 lon domain protein	-	-	-	ko:K07157	-	-	-	-	ko00000	-	-	-	LON_substr_bdg
HKD2_k127_224392_1	1121877.JQKF01000014_gene16	2.049e-68	244.0	COG0673@1|root,COG0673@2|Bacteria,2HFKH@201174|Actinobacteria,4CP3Y@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
HKD2_k127_2245506_1	485913.Krac_7542	2.191e-07	57.0	COG1187@1|root,COG1187@2|Bacteria	2|Bacteria	J	pseudouridine synthase activity	rluB	-	5.4.99.22	ko:K06178	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
HKD2_k127_2245506_0	485913.Krac_7539	8.448e-157	497.0	COG0010@1|root,COG0010@2|Bacteria,2G6IN@200795|Chloroflexi	200795|Chloroflexi	E	Arginase family	-	-	3.5.3.11	ko:K01480	ko00330,ko01100,map00330,map01100	M00133	R01157	RC00024,RC00329	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
HKD2_k127_2250454_0	485913.Krac_7856	3.853e-110	366.0	COG0172@1|root,COG0172@2|Bacteria,2G5PD@200795|Chloroflexi	200795|Chloroflexi	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	-	-	-	-	-	-	-	-	-	-	-	-	tRNA-synt_2b
HKD2_k127_2250454_2	1382306.JNIM01000001_gene872	7.308e-06	50.0	COG2204@1|root,COG2204@2|Bacteria,2G5ZP@200795|Chloroflexi	200795|Chloroflexi	T	Two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD2_k127_2251411_1	485913.Krac_7774	8.4e-130	421.0	COG0750@1|root,COG0750@2|Bacteria,2G6HV@200795|Chloroflexi	200795|Chloroflexi	M	TIGRFAM membrane-associated zinc metalloprotease	-	-	-	ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_M50
HKD2_k127_2251411_0	485913.Krac_7775	2.844e-181	574.0	COG0743@1|root,COG0743@2|Bacteria,2G5RB@200795|Chloroflexi	200795|Chloroflexi	I	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)	dxr	-	1.1.1.267	ko:K00099	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05688	RC01452	ko00000,ko00001,ko00002,ko01000	-	-	-	DXPR_C,DXP_redisom_C,DXP_reductoisom
HKD2_k127_2251411_2	485913.Krac_1926	9.219e-19	85.0	COG3464@1|root,COG3464@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_ISL3,HTH_23,HTH_7,zf-ISL3
HKD2_k127_2288380_1	485913.Krac_12492	1.486e-141	454.0	COG0010@1|root,COG0010@2|Bacteria,2G5N5@200795|Chloroflexi	200795|Chloroflexi	E	Belongs to the arginase family	-	-	3.5.3.1	ko:K01476	ko00220,ko00330,ko01100,ko01110,ko01130,ko01230,ko05146,map00220,map00330,map01100,map01110,map01130,map01230,map05146	M00029,M00134	R00551	RC00024,RC00329	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
HKD2_k127_2288380_0	485913.Krac_12493	1.858e-163	518.0	COG0115@1|root,COG0115@2|Bacteria,2G5PM@200795|Chloroflexi	200795|Chloroflexi	E	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family	ilvE	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
HKD2_k127_2288380_3	1382306.JNIM01000001_gene3517	9.95e-55	194.0	COG0103@1|root,COG0103@2|Bacteria,2G6UZ@200795|Chloroflexi	200795|Chloroflexi	J	Belongs to the universal ribosomal protein uS9 family	rpsI	-	-	ko:K02996	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S9
HKD2_k127_2288380_2	485913.Krac_12498	6.335e-79	265.0	COG0102@1|root,COG0102@2|Bacteria,2G6M4@200795|Chloroflexi	200795|Chloroflexi	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly	rplM	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02871	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13
HKD2_k127_2288380_4	485913.Krac_12499	9.392e-18	83.0	COG0101@1|root,COG0101@2|Bacteria,2G6PE@200795|Chloroflexi	200795|Chloroflexi	J	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs	truA	GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016853,GO:0016866,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360	5.4.99.12	ko:K06173	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PseudoU_synth_1
HKD2_k127_2300038_4	485913.Krac_11484	0.0003034	46.0	2BW85@1|root,33A8F@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2300038_2	696281.Desru_0907	2.428e-36	147.0	COG2082@1|root,COG2082@2|Bacteria,1V1SX@1239|Firmicutes,24B9Z@186801|Clostridia,26213@186807|Peptococcaceae	186801|Clostridia	H	PFAM Precorrin-8X methylmutase	cobH	-	5.4.99.60,5.4.99.61	ko:K06042	ko00860,ko01100,map00860,map01100	-	R05177,R05814	RC01292,RC01980	ko00000,ko00001,ko01000	-	-	-	CbiC
HKD2_k127_2300038_0	1234664.AMRO01000003_gene672	1.796e-103	348.0	COG1903@1|root,COG1903@2|Bacteria,1TQ3M@1239|Firmicutes,4HBDG@91061|Bacilli,1WFXC@129337|Geobacillus	91061|Bacilli	H	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A	cbiD	-	2.1.1.195	ko:K02188	ko00860,ko01100,map00860,map01100	-	R07773	RC00003,RC02051	ko00000,ko00001,ko01000	-	-	-	CbiD
HKD2_k127_2300038_1	1200792.AKYF01000008_gene766	7.205e-49	182.0	COG2241@1|root,COG2242@1|root,COG2241@2|Bacteria,COG2242@2|Bacteria,1TS3H@1239|Firmicutes,4HAP3@91061|Bacilli,26SF4@186822|Paenibacillaceae	91061|Bacilli	H	Tetrapyrrole (Corrin/Porphyrin) Methylases	cbiET	-	2.1.1.132	ko:K00595	ko00860,ko01100,map00860,map01100	-	R05149	RC00003,RC01279	ko00000,ko00001,ko01000	-	-	-	Methyltransf_18,PCMT,TP_methylase
HKD2_k127_2300038_3	243231.GSU2995	1.525e-29	122.0	COG2243@1|root,COG2243@2|Bacteria,1MV3G@1224|Proteobacteria,42MGC@68525|delta/epsilon subdivisions,2WM51@28221|Deltaproteobacteria,43SH5@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	PFAM Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase	cbiL	-	2.1.1.130,2.1.1.151	ko:K03394	ko00860,ko01100,map00860,map01100	-	R03948,R05808	RC00003,RC01035,RC01662	ko00000,ko00001,ko01000	-	-	iAF987.Gmet_0482	TP_methylase
HKD2_k127_2300173_0	1382306.JNIM01000001_gene1145	1.275e-161	515.0	COG2309@1|root,COG2309@2|Bacteria	2|Bacteria	E	aminopeptidase activity	-	-	-	ko:K19689	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M29
HKD2_k127_2300173_1	485913.Krac_6492	3.435e-24	102.0	COG3316@1|root,COG3316@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,Transposase_mut,zf-IS66
HKD2_k127_231657_0	485913.Krac_11839	8.234e-144	469.0	COG1249@1|root,COG1249@2|Bacteria	2|Bacteria	C	cell redox homeostasis	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,Pyr_redox_dim
HKD2_k127_231657_1	485913.Krac_11840	3.798e-51	187.0	COG1597@1|root,COG1597@2|Bacteria,2G70R@200795|Chloroflexi	200795|Chloroflexi	I	PFAM diacylglycerol kinase catalytic region	-	-	-	-	-	-	-	-	-	-	-	-	DAGK_cat
HKD2_k127_2317148_1	485913.Krac_8713	2.831e-108	355.0	28MW3@1|root,2ZB3G@2|Bacteria,2G8UY@200795|Chloroflexi	200795|Chloroflexi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2317148_0	485913.Krac_8714	2.432e-311	960.0	COG0433@1|root,COG0433@2|Bacteria,2G78T@200795|Chloroflexi	200795|Chloroflexi	S	Domain of unknown function DUF87	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF87
HKD2_k127_2317148_2	1382306.JNIM01000001_gene4183	2.185e-68	243.0	COG0859@1|root,COG0859@2|Bacteria	2|Bacteria	M	ADP-heptose-lipopolysaccharide heptosyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_9
HKD2_k127_2326559_0	326427.Cagg_0751	4.415e-163	552.0	COG0842@1|root,COG1131@1|root,COG1716@1|root,COG0842@2|Bacteria,COG1131@2|Bacteria,COG1716@2|Bacteria,2G7J8@200795|Chloroflexi,374RZ@32061|Chloroflexia	32061|Chloroflexia	V	ABC transporter related	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane,ABC_tran,FHA
HKD2_k127_2326559_1	485913.Krac_11872	3.335e-09	57.0	COG3385@1|root,COG3385@2|Bacteria,2G7KG@200795|Chloroflexi	200795|Chloroflexi	L	PFAM transposase, IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
HKD2_k127_2338893_1	1382306.JNIM01000001_gene910	1.914e-150	481.0	COG1171@1|root,COG1171@2|Bacteria,2G5YN@200795|Chloroflexi	200795|Chloroflexi	E	Pyridoxal-phosphate dependent enzyme	-	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HKD2_k127_2338893_0	485913.Krac_8347	0.0	1069.0	COG1196@1|root,COG4581@1|root,COG1196@2|Bacteria,COG4581@2|Bacteria,2G7P6@200795|Chloroflexi	200795|Chloroflexi	L	DSHCT	-	-	-	ko:K03727	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,DSHCT,Helicase_C
HKD2_k127_2345762_0	485913.Krac_9803	4.54e-74	266.0	COG0457@1|root,COG4249@1|root,COG0457@2|Bacteria,COG4249@2|Bacteria	2|Bacteria	S	B-1 B cell differentiation	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C14,WD40
HKD2_k127_2345762_1	485913.Krac_9804	4.851e-05	46.0	COG0488@1|root,COG0488@2|Bacteria,2G5VD@200795|Chloroflexi	200795|Chloroflexi	S	PFAM ABC transporter related	-	-	-	ko:K06158	-	-	-	-	ko00000,ko03012	-	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
HKD2_k127_2363007_2	485913.Krac_3297	2.54e-107	353.0	COG1028@1|root,COG1028@2|Bacteria,2G85A@200795|Chloroflexi	200795|Chloroflexi	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HKD2_k127_2363007_1	485913.Krac_3296	5.7e-150	482.0	COG0809@1|root,COG0809@2|Bacteria,2G7UA@200795|Chloroflexi	200795|Chloroflexi	H	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)	-	-	2.4.99.17	ko:K07568	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Queuosine_synth
HKD2_k127_2363007_0	309801.trd_A0017	3.382e-200	636.0	COG0606@1|root,COG0606@2|Bacteria,2G65P@200795|Chloroflexi,27Y2X@189775|Thermomicrobia	189775|Thermomicrobia	O	Magnesium chelatase, subunit ChlI	-	-	-	ko:K07391	-	-	-	-	ko00000	-	-	-	ChlI,Mg_chelatase,Mg_chelatase_C
HKD2_k127_2364627_1	485913.Krac_2793	6.704e-42	158.0	COG0619@1|root,COG0619@2|Bacteria	2|Bacteria	P	transmembrane transporter activity	-	-	-	ko:K16783,ko:K16785	ko02010,map02010	M00581,M00582	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.25,3.A.1.25.1,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	CbiQ
HKD2_k127_2364627_0	485913.Krac_12023	2.226e-101	342.0	COG5542@1|root,COG5542@2|Bacteria,2G72S@200795|Chloroflexi	200795|Chloroflexi	S	integral membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	Mannosyl_trans2
HKD2_k127_2364627_2	1040989.AWZU01000008_gene3685	6.963e-36	139.0	COG3509@1|root,COG3509@2|Bacteria,1MXUI@1224|Proteobacteria,2TUS5@28211|Alphaproteobacteria,3JRUS@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	Esterase PHB depolymerase	-	-	-	-	-	-	-	-	-	-	-	-	Esterase_phd
HKD2_k127_2370582_2	395961.Cyan7425_3363	7.289e-39	147.0	COG0765@1|root,COG0765@2|Bacteria,1G0FV@1117|Cyanobacteria	1117|Cyanobacteria	P	TIGRFAM amine acid ABC transporter, permease protein, 3-TM region, His Glu Gln Arg opine family	-	-	-	ko:K02029,ko:K09971	ko02010,map02010	M00232,M00236	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3,3.A.1.3.18,3.A.1.3.7,3.A.1.3.8	-	-	BPD_transp_1
HKD2_k127_2370582_3	485913.Krac_7527	1.406e-22	103.0	COG0675@1|root,COG0675@2|Bacteria	2|Bacteria	L	Transposase, IS605 OrfB family	-	-	-	ko:K07496	-	-	-	-	ko00000	-	-	-	OrfB_Zn_ribbon
HKD2_k127_2370582_1	429009.Adeg_0497	8.82e-43	162.0	COG1943@1|root,COG1943@2|Bacteria,1VAIQ@1239|Firmicutes,25CMR@186801|Clostridia	186801|Clostridia	L	Transposase IS200 like	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
HKD2_k127_2370582_0	485913.Krac_0388	4.093e-43	164.0	COG0515@1|root,COG0515@2|Bacteria	485913.Krac_0388|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2384220_0	485913.Krac_10921	1.882e-102	336.0	COG1293@1|root,COG1293@2|Bacteria,2G5TC@200795|Chloroflexi	200795|Chloroflexi	K	Fibronectin-binding A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF814,FbpA
HKD2_k127_2384220_1	485913.Krac_10518	1.331e-51	188.0	COG0545@1|root,COG0545@2|Bacteria,2G9DQ@200795|Chloroflexi	200795|Chloroflexi	O	FKBP-type peptidyl-prolyl cis-trans isomerase	-	-	-	-	-	-	-	-	-	-	-	-	FKBP_C
HKD2_k127_2385121_2	1347086.CCBA010000005_gene4061	1.31e-09	65.0	COG2045@1|root,COG2045@2|Bacteria,1TTEV@1239|Firmicutes,4HGDY@91061|Bacilli,1ZFKP@1386|Bacillus	91061|Bacilli	H	Belongs to the ComB family	-	GO:0003674,GO:0003824,GO:0016829,GO:0016830,GO:0016831,GO:0050545	3.1.3.71	ko:K05979	ko00680,ko01120,map00680,map01120	M00358	R05789	RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	2-ph_phosp
HKD2_k127_2385121_0	1382306.JNIM01000001_gene1199	6.317e-199	625.0	COG1960@1|root,COG1960@2|Bacteria,2G6E5@200795|Chloroflexi	200795|Chloroflexi	C	PFAM acyl-CoA dehydrogenase domain protein	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HKD2_k127_2385121_1	485913.Krac_11030	8.573e-61	213.0	COG1960@1|root,COG1960@2|Bacteria,2G8BF@200795|Chloroflexi	200795|Chloroflexi	C	PFAM acyl-CoA dehydrogenase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HKD2_k127_2388468_2	485913.Krac_2926	1.429e-17	83.0	COG2197@1|root,COG3903@1|root,COG2197@2|Bacteria,COG3903@2|Bacteria,2G7W3@200795|Chloroflexi	200795|Chloroflexi	K	transcriptional regulator, LuxR family	-	-	-	-	-	-	-	-	-	-	-	-	AAA_22,GerE,NB-ARC,TPR_12
HKD2_k127_2388468_1	269797.Mbar_A3082	5.243e-46	172.0	COG4894@1|root,arCOG03995@2157|Archaea,2XXXJ@28890|Euryarchaeota,2NB1N@224756|Methanomicrobia	224756|Methanomicrobia	S	LURP-one-related	-	-	-	-	-	-	-	-	-	-	-	-	LOR
HKD2_k127_2388468_0	269797.Mbar_A3082	1.851e-52	191.0	COG4894@1|root,arCOG03995@2157|Archaea,2XXXJ@28890|Euryarchaeota,2NB1N@224756|Methanomicrobia	224756|Methanomicrobia	S	LURP-one-related	-	-	-	-	-	-	-	-	-	-	-	-	LOR
HKD2_k127_2392588_1	485913.Krac_10209	1.185e-94	317.0	COG4447@1|root,COG4447@2|Bacteria	2|Bacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	BNR
HKD2_k127_2392588_0	1382306.JNIM01000001_gene375	1.182e-116	388.0	COG1276@1|root,COG2372@1|root,COG1276@2|Bacteria,COG2372@2|Bacteria,2G8KM@200795|Chloroflexi	200795|Chloroflexi	P	PFAM copper resistance protein CopC	-	-	-	ko:K14166	-	-	-	-	ko00000,ko02000	-	-	-	CopC,CopD
HKD2_k127_2414225_1	485913.Krac_8584	1.31e-53	192.0	COG0791@1|root,COG0791@2|Bacteria	2|Bacteria	M	cysteine-type peptidase activity	-	-	-	ko:K21471	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	CHAP,CW_binding_1,NLPC_P60
HKD2_k127_2414225_0	1382306.JNIM01000001_gene3833	2.078e-66	230.0	COG0663@1|root,COG0663@2|Bacteria,2G70N@200795|Chloroflexi	200795|Chloroflexi	S	PFAM transferase hexapeptide repeat containing protein	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep
HKD2_k127_2414225_2	485913.Krac_8525	8.181e-31	125.0	COG1276@1|root,COG2372@1|root,COG1276@2|Bacteria,COG2372@2|Bacteria	2|Bacteria	C	response to copper ion	-	-	-	ko:K07156,ko:K14166	-	-	-	-	ko00000,ko02000	9.B.62.2	-	-	CopC,CopD,YtkA
HKD2_k127_2425160_1	1382306.JNIM01000001_gene1951	7.546e-89	295.0	COG0225@1|root,COG0225@2|Bacteria,2G6JK@200795|Chloroflexi	200795|Chloroflexi	C	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	msrA	-	1.8.4.11	ko:K07304	-	-	-	-	ko00000,ko01000	-	-	-	PMSR
HKD2_k127_2425160_4	485913.Krac_3284	9.584e-08	54.0	COG3387@1|root,COG3387@2|Bacteria,2G7S0@200795|Chloroflexi	2|Bacteria	G	COGs COG3387 Glucoamylase and related glycosyl hydrolase	-	-	-	ko:K07190	ko04020,ko04910,ko04922,map04020,map04910,map04922	-	-	-	ko00000,ko00001	-	-	-	Glyco_hydro_15
HKD2_k127_2425160_0	234267.Acid_7579	1.637e-132	435.0	COG0738@1|root,COG0738@2|Bacteria,3Y92Y@57723|Acidobacteria	57723|Acidobacteria	G	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2425160_3	234267.Acid_7578	7.58e-20	90.0	COG2303@1|root,COG2303@2|Bacteria,3Y456@57723|Acidobacteria	57723|Acidobacteria	E	GMC oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GMC_oxred_C,GMC_oxred_N
HKD2_k127_2425160_2	765952.PUV_21440	1.59e-77	262.0	COG2303@1|root,COG2303@2|Bacteria,2JGPG@204428|Chlamydiae	204428|Chlamydiae	E	GMC oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GMC_oxred_C,GMC_oxred_N
HKD2_k127_2437734_1	102125.Xen7305DRAFT_00048670	2.976e-05	46.0	COG3335@1|root,COG3335@2|Bacteria	2|Bacteria	L	DDE superfamily endonuclease	-	-	-	ko:K07494	-	-	-	-	ko00000	-	-	-	DDE_3
HKD2_k127_2437734_0	1382306.JNIM01000001_gene110	9.461e-291	919.0	COG0744@1|root,COG0744@2|Bacteria,2G5ZG@200795|Chloroflexi	200795|Chloroflexi	M	PFAM glycosyl transferase, family 51	-	-	-	-	-	-	-	-	-	-	-	-	BiPBP_C,Transgly,Transpeptidase
HKD2_k127_2439103_0	1499967.BAYZ01000026_gene1631	1.677e-59	216.0	COG0367@1|root,COG0367@2|Bacteria,2NNKE@2323|unclassified Bacteria	2|Bacteria	E	PFAM asparagine synthase	asnB	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
HKD2_k127_2453859_0	485913.Krac_10599	2.495e-157	503.0	COG0836@1|root,COG0836@2|Bacteria,2G5WW@200795|Chloroflexi	200795|Chloroflexi	M	Nucleotidyl transferase	-	-	2.7.7.13	ko:K00971	ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110	M00114,M00361,M00362	R00885	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	MannoseP_isomer,NTP_transferase
HKD2_k127_2477038_0	102125.Xen7305DRAFT_00024090	1.2e-32	130.0	COG2801@1|root,COG2801@2|Bacteria,1G1WB@1117|Cyanobacteria	2|Bacteria	L	PFAM Mu transposase, C-terminal	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_23,HTH_28,Mu-transpos_C,rve
HKD2_k127_2477038_1	1296415.JACC01000007_gene2456	1.825e-08	67.0	COG3291@1|root,COG3291@2|Bacteria,4NNHP@976|Bacteroidetes,1I21K@117743|Flavobacteriia,2YHE0@290174|Aquimarina	976|Bacteroidetes	Q	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,VCBS,fn3
HKD2_k127_248775_1	485913.Krac_12484	4.288e-51	188.0	COG0360@1|root,COG0360@2|Bacteria,2G7DG@200795|Chloroflexi	200795|Chloroflexi	J	Binds together with S18 to 16S ribosomal RNA	rpsF	-	-	ko:K02990	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S6
HKD2_k127_248775_2	485913.Krac_12485	6.272e-51	183.0	COG0629@1|root,COG0629@2|Bacteria,2G6YE@200795|Chloroflexi	200795|Chloroflexi	L	Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism	-	-	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
HKD2_k127_248775_3	485913.Krac_12486	2.126e-43	160.0	COG0238@1|root,COG0238@2|Bacteria,2G756@200795|Chloroflexi	200795|Chloroflexi	J	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit	rpsR	-	-	ko:K02963	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S18
HKD2_k127_248775_0	1382306.JNIM01000001_gene3510	3.866e-76	265.0	COG0760@1|root,COG0760@2|Bacteria,2G6RV@200795|Chloroflexi	200795|Chloroflexi	O	PFAM PpiC-type peptidyl-prolyl cis-trans isomerase	-	-	-	-	-	-	-	-	-	-	-	-	Rotamase,Rotamase_3,SurA_N_3
HKD2_k127_248775_4	1382306.JNIM01000001_gene3510	6.318e-05	45.0	COG0760@1|root,COG0760@2|Bacteria,2G6RV@200795|Chloroflexi	200795|Chloroflexi	O	PFAM PpiC-type peptidyl-prolyl cis-trans isomerase	-	-	-	-	-	-	-	-	-	-	-	-	Rotamase,Rotamase_3,SurA_N_3
HKD2_k127_2499630_3	1463887.KL590009_gene3230	3.355e-05	52.0	COG3548@1|root,COG3548@2|Bacteria,2GRE3@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF1211)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1211
HKD2_k127_2499630_2	485913.Krac_3669	2.655e-66	240.0	COG4129@1|root,COG4129@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	ArAE_1,FUSC,FUSC_2
HKD2_k127_2499630_0	485913.Krac_11194	1.858e-188	595.0	COG0520@1|root,COG0520@2|Bacteria,2G7ZH@200795|Chloroflexi	200795|Chloroflexi	E	DegT/DnrJ/EryC1/StrS aminotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
HKD2_k127_2499630_1	485913.Krac_11196	3.333e-155	499.0	COG2170@1|root,COG2170@2|Bacteria,2G5NR@200795|Chloroflexi	200795|Chloroflexi	H	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity	-	-	-	ko:K06048	-	-	-	-	ko00000,ko01000	-	-	-	GCS2
HKD2_k127_2507040_0	485913.Krac_10288	1.817e-111	366.0	COG0277@1|root,COG0277@2|Bacteria,2G6FW@200795|Chloroflexi	200795|Chloroflexi	C	PFAM FAD linked oxidase domain protein	-	-	-	ko:K11472	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	FAD-oxidase_C,FAD_binding_4
HKD2_k127_2507483_0	485913.Krac_9054	2.857e-144	463.0	COG1008@1|root,COG1008@2|Bacteria,2G5VU@200795|Chloroflexi	200795|Chloroflexi	C	TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain M	-	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q5_N,Proton_antipo_M
HKD2_k127_2507483_1	485913.Krac_9055	2.373e-16	79.0	COG1007@1|root,COG1007@2|Bacteria,2G5ZK@200795|Chloroflexi	200795|Chloroflexi	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoN	-	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
HKD2_k127_2512660_1	485913.Krac_9045	2.866e-49	177.0	COG1905@1|root,COG1905@2|Bacteria,2G70Y@200795|Chloroflexi	200795|Chloroflexi	C	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit	-	-	1.6.5.3	ko:K00334	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
HKD2_k127_2512660_0	485913.Krac_9046	4.541e-232	722.0	COG1894@1|root,COG1894@2|Bacteria,2G5W1@200795|Chloroflexi	200795|Chloroflexi	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain	nuoF	-	1.6.5.3	ko:K00335	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_51K,NADH_4Fe-4S,SLBB
HKD2_k127_2514909_0	1242864.D187_010372	5.613e-40	166.0	COG2202@1|root,COG5002@1|root,COG2202@2|Bacteria,COG5002@2|Bacteria	2|Bacteria	T	protein histidine kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9
HKD2_k127_252593_0	1382306.JNIM01000001_gene274	1.967e-65	226.0	COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,2G6X3@200795|Chloroflexi	200795|Chloroflexi	H	NAD synthase	-	-	6.3.1.5	ko:K01916	ko00760,ko01100,map00760,map01100	M00115	R00189	RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	NAD_synthase
HKD2_k127_2540705_0	1173023.KE650771_gene4438	5.988e-141	460.0	COG0465@1|root,COG0465@2|Bacteria,1G46Q@1117|Cyanobacteria	1117|Cyanobacteria	O	PFAM ATPase family associated with various cellular activities (AAA)	-	-	-	-	-	-	-	-	-	-	-	-	AAA
HKD2_k127_2540705_1	485913.Krac_1477	6.99e-74	252.0	COG1633@1|root,COG1633@2|Bacteria,2G8RM@200795|Chloroflexi	200795|Chloroflexi	S	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2540779_0	485913.Krac_11841	2.021e-121	396.0	COG0671@1|root,COG0671@2|Bacteria,2G8YH@200795|Chloroflexi	200795|Chloroflexi	I	Acid phosphatase homologues	-	-	-	-	-	-	-	-	-	-	-	-	PAP2
HKD2_k127_2540779_1	485913.Krac_11840	3.487e-47	175.0	COG1597@1|root,COG1597@2|Bacteria,2G70R@200795|Chloroflexi	200795|Chloroflexi	I	PFAM diacylglycerol kinase catalytic region	-	-	-	-	-	-	-	-	-	-	-	-	DAGK_cat
HKD2_k127_2552375_1	1382306.JNIM01000001_gene977	2.797e-61	217.0	COG0477@1|root,COG2814@2|Bacteria	1382306.JNIM01000001_gene977|-	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2552375_0	1382306.JNIM01000001_gene974	3.416e-72	245.0	COG0842@1|root,COG0842@2|Bacteria,2G5UH@200795|Chloroflexi	200795|Chloroflexi	V	PFAM ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
HKD2_k127_2558716_5	1210884.HG799477_gene15428	1.659e-45	169.0	28JEU@1|root,2Z98W@2|Bacteria	2|Bacteria	S	PFAM MULE transposase, conserved domain	-	-	-	-	-	-	-	-	-	-	-	-	MULE,Transposase_mut
HKD2_k127_2558716_2	485913.Krac_6184	5.509e-94	313.0	28JEU@1|root,2Z98W@2|Bacteria	2|Bacteria	S	PFAM MULE transposase, conserved domain	-	-	-	-	-	-	-	-	-	-	-	-	MULE,Transposase_mut
HKD2_k127_2558716_4	485913.Krac_12093	1.824e-65	225.0	COG0346@1|root,COG0346@2|Bacteria,2G79M@200795|Chloroflexi	200795|Chloroflexi	E	PFAM Glyoxalase bleomycin resistance protein dioxygenase	-	-	5.1.99.1	ko:K05606	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00375,M00376,M00741	R02765,R09979	RC00780,RC02739	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyoxalase_4
HKD2_k127_2558716_1	485913.Krac_12096	2.005e-110	365.0	COG1235@1|root,COG1235@2|Bacteria,2G711@200795|Chloroflexi	200795|Chloroflexi	S	beta-lactamase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
HKD2_k127_2558716_0	1382306.JNIM01000001_gene3781	1.129e-146	469.0	COG2159@1|root,COG2159@2|Bacteria,2G6CW@200795|Chloroflexi	200795|Chloroflexi	S	PFAM amidohydrolase 2	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
HKD2_k127_2566918_1	485913.Krac_11920	3.089e-73	250.0	COG1468@1|root,COG1468@2|Bacteria,2G6VA@200795|Chloroflexi	200795|Chloroflexi	L	Domain of unknown function DUF83	-	-	3.1.12.1	ko:K07464	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	Cas_Cas4
HKD2_k127_2566918_0	1382306.JNIM01000001_gene2899	2.943e-197	625.0	COG1915@1|root,COG1915@2|Bacteria	2|Bacteria	E	PFAM LOR SDH bifunctional enzyme conserved region	-	-	-	-	-	-	-	-	-	-	-	-	Amidinotransf,Saccharop_dh_N
HKD2_k127_2593211_1	485913.Krac_11263	2.634e-48	175.0	COG3429@1|root,COG3429@2|Bacteria,2G6ZV@200795|Chloroflexi	200795|Chloroflexi	G	Glucose-6-phosphate dehydrogenase subunit	-	-	-	-	-	-	-	-	-	-	-	-	OpcA_G6PD_assem
HKD2_k127_2593211_0	485913.Krac_11262	1.74e-297	916.0	COG0364@1|root,COG0364@2|Bacteria,2G5MB@200795|Chloroflexi	200795|Chloroflexi	G	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone	zwf	-	1.1.1.363,1.1.1.49	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	M00004,M00006,M00008	R00835,R02736,R10907	RC00001,RC00066	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	G6PD_C,G6PD_N
HKD2_k127_2596264_0	485913.Krac_12092	1.149e-305	941.0	COG4799@1|root,COG4799@2|Bacteria,2G5IX@200795|Chloroflexi	200795|Chloroflexi	I	PFAM carboxyl transferase	-	-	2.1.3.15,6.4.1.3	ko:K01966	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R01859	RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
HKD2_k127_2620579_0	485913.Krac_4955	2.454e-29	119.0	COG5002@1|root,COG5002@2|Bacteria,2G66G@200795|Chloroflexi	2|Bacteria	T	histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HAMP,HATPase_c,HisKA,PAS_4,dCache_1
HKD2_k127_2620579_1	485913.Krac_7177	4.167e-29	126.0	COG0589@1|root,COG0589@2|Bacteria,2G94S@200795|Chloroflexi	200795|Chloroflexi	T	COGs COG0589 Universal stress protein UspA and related nucleotide-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD2_k127_262162_2	485913.Krac_8453	9.091e-10	61.0	COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,2G5Y8@200795|Chloroflexi	200795|Chloroflexi	H	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	-	4.2.1.136,5.1.99.6	ko:K17758,ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	Carb_kinase,YjeF_N
HKD2_k127_262162_1	485913.Krac_2054	1.1e-26	111.0	COG5470@1|root,COG5470@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF1330
HKD2_k127_262162_0	485913.Krac_8450	1.749e-134	436.0	COG0863@1|root,COG0863@2|Bacteria	2|Bacteria	L	N-4 methylation of cytosine	-	-	2.1.1.113	ko:K00590	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	MethyltransfD12,N6_N4_Mtase,UPF0020
HKD2_k127_262282_0	485913.Krac_1376	1.126e-271	845.0	COG0111@1|root,COG0111@2|Bacteria,2G67B@200795|Chloroflexi	200795|Chloroflexi	C	D-isomer specific 2-hydroxyacid dehydrogenase	serA	-	1.1.1.310,1.1.1.399,1.1.1.95	ko:K00058,ko:K16843	ko00260,ko00270,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00270,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513,R05693	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C,ACT
HKD2_k127_262282_1	1382306.JNIM01000001_gene1073	2.783e-178	565.0	COG0075@1|root,COG0075@2|Bacteria,2G5P3@200795|Chloroflexi	200795|Chloroflexi	E	PFAM aminotransferase class V	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
HKD2_k127_2635680_0	485913.Krac_7672	2.109e-197	620.0	COG3808@1|root,COG3808@2|Bacteria,2G5N7@200795|Chloroflexi	200795|Chloroflexi	C	Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
HKD2_k127_2643023_0	485913.Krac_9184	1.401e-263	842.0	COG0744@1|root,COG0744@2|Bacteria,2G5ZG@200795|Chloroflexi	2|Bacteria	M	PFAM glycosyl transferase, family 51	mrcB	-	2.4.1.129,3.4.16.4	ko:K05365,ko:K05367	ko00550,map00550	-	R04519	RC00005,RC00049	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase,UB2H
HKD2_k127_2643023_1	485913.Krac_9183	1.044e-95	316.0	COG2452@1|root,COG2452@2|Bacteria,2G789@200795|Chloroflexi	200795|Chloroflexi	L	PFAM regulatory protein, MerR	-	-	-	-	-	-	-	-	-	-	-	-	HTH_17
HKD2_k127_2657464_2	485913.Krac_7993	2.024e-195	617.0	COG0143@1|root,COG0143@2|Bacteria	2|Bacteria	J	methionyl-tRNA aminoacylation	metG	GO:0003674,GO:0003824,GO:0004812,GO:0004825,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006431,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1g
HKD2_k127_2657464_0	485913.Krac_7985	5.196e-273	850.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria	485913.Krac_7985|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2657464_1	485913.Krac_7986	6.433e-213	675.0	COG0457@1|root,COG0457@2|Bacteria	485913.Krac_7986|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2660235_2	485913.Krac_6977	3.52e-85	298.0	COG2244@1|root,COG2244@2|Bacteria	2|Bacteria	S	polysaccharide biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt,Polysacc_synt_C
HKD2_k127_2660235_0	485913.Krac_8878	7.184e-165	521.0	COG0612@1|root,COG0612@2|Bacteria,2G672@200795|Chloroflexi	200795|Chloroflexi	S	PFAM peptidase M16 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
HKD2_k127_2673555_0	1382306.JNIM01000001_gene617	1.685e-45	179.0	COG1686@1|root,COG1686@2|Bacteria	2|Bacteria	M	Belongs to the peptidase S11 family	-	-	3.4.16.4	ko:K07258	ko00550,ko01100,map00550,map01100	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	Beta-lactamase2,PG_binding_1,Peptidase_S11
HKD2_k127_2675243_0	485913.Krac_10191	1.361e-137	441.0	COG0210@1|root,COG0210@2|Bacteria,2G5XF@200795|Chloroflexi	200795|Chloroflexi	L	PFAM UvrD REP helicase	-	-	-	-	-	-	-	-	-	-	-	-	UvrD-helicase,UvrD_C
HKD2_k127_2675243_6	485913.Krac_10191	7.797e-14	73.0	COG0210@1|root,COG0210@2|Bacteria,2G5XF@200795|Chloroflexi	200795|Chloroflexi	L	PFAM UvrD REP helicase	-	-	-	-	-	-	-	-	-	-	-	-	UvrD-helicase,UvrD_C
HKD2_k127_2675243_1	485913.Krac_10189	5.602e-107	355.0	COG1122@1|root,COG1122@2|Bacteria,2G5RY@200795|Chloroflexi	200795|Chloroflexi	P	PFAM ABC transporter related	ecfA	-	-	ko:K16786,ko:K16787	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	ABC_tran
HKD2_k127_2675243_2	485913.Krac_10188	8.121e-106	351.0	COG1122@1|root,COG1122@2|Bacteria,2G5RY@200795|Chloroflexi	2|Bacteria	P	PFAM ABC transporter related	ecfA	-	-	ko:K16784,ko:K16787	ko02010,map02010	M00581,M00582	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.25,3.A.1.25.1,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	ABC_tran
HKD2_k127_2675243_4	485913.Krac_10187	9.857e-23	105.0	COG0619@1|root,COG0619@2|Bacteria	2|Bacteria	P	transmembrane transporter activity	-	-	-	ko:K16785,ko:K16786,ko:K16787	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	ABC_tran,CbiQ
HKD2_k127_2675243_5	485913.Krac_10187	2.829e-15	80.0	COG0619@1|root,COG0619@2|Bacteria	2|Bacteria	P	transmembrane transporter activity	-	-	-	ko:K16785,ko:K16786,ko:K16787	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	ABC_tran,CbiQ
HKD2_k127_2678146_0	485913.Krac_4768	7.752e-82	285.0	COG2334@1|root,COG2334@2|Bacteria	2|Bacteria	S	homoserine kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	APH
HKD2_k127_2678146_1	1304865.JAGF01000001_gene2811	2.182e-05	49.0	COG2141@1|root,COG2141@2|Bacteria,2HGTQ@201174|Actinobacteria	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
HKD2_k127_2683024_2	1382306.JNIM01000001_gene356	3.858e-124	415.0	COG0744@1|root,COG0744@2|Bacteria,2G5ZG@200795|Chloroflexi	200795|Chloroflexi	M	PFAM glycosyl transferase, family 51	-	-	-	-	-	-	-	-	-	-	-	-	BiPBP_C,Transgly,Transpeptidase
HKD2_k127_2683024_4	485913.Krac_8372	2.227e-101	349.0	COG0308@1|root,COG0308@2|Bacteria,2G6SD@200795|Chloroflexi	200795|Chloroflexi	E	Peptidase MA superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_MA_2
HKD2_k127_2683024_1	1382306.JNIM01000001_gene354	2.381e-129	423.0	COG0758@1|root,COG0758@2|Bacteria,2G5UA@200795|Chloroflexi	200795|Chloroflexi	L	TIGRFAM DNA protecting protein DprA	-	-	-	ko:K04096	-	-	-	-	ko00000	-	-	-	DNA_processg_A
HKD2_k127_2683024_0	1382306.JNIM01000001_gene353	0.0	1091.0	COG0770@1|root,COG0787@1|root,COG0770@2|Bacteria,COG0787@2|Bacteria,2G66N@200795|Chloroflexi	200795|Chloroflexi	M	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids	alr	-	5.1.1.1	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	-	R00401	RC00285	ko00000,ko00001,ko01000,ko01011	-	-	-	Ala_racemase_C,Ala_racemase_N,Mur_ligase,Mur_ligase_C,Mur_ligase_M
HKD2_k127_2683024_3	485913.Krac_8381	4.837e-109	364.0	COG1597@1|root,COG1597@2|Bacteria,2G70R@200795|Chloroflexi	200795|Chloroflexi	I	PFAM diacylglycerol kinase catalytic region	-	-	-	-	-	-	-	-	-	-	-	-	DAGK_cat
HKD2_k127_2697724_2	1487953.JMKF01000051_gene2014	3.325e-25	110.0	COG0191@1|root,COG0191@2|Bacteria,1G3MT@1117|Cyanobacteria,1H76W@1150|Oscillatoriales	1117|Cyanobacteria	G	Ketose-bisphosphate aldolase	-	-	4.1.2.40	ko:K08302	ko00052,ko01100,map00052,map01100	-	R01069	RC00438,RC00439	ko00000,ko00001,ko01000	-	-	-	F_bP_aldolase
HKD2_k127_2697724_0	1227349.C170_12225	8.198e-113	381.0	COG3395@1|root,COG3395@2|Bacteria,1TRZ8@1239|Firmicutes,4HAS4@91061|Bacilli,26VK7@186822|Paenibacillaceae	91061|Bacilli	S	Putative nucleotide-binding of sugar-metabolising enzyme	-	-	-	-	-	-	-	-	-	-	-	-	DUF1357_C,DUF1537
HKD2_k127_2697724_1	1441629.PCH70_21250	2.239e-56	201.0	COG1028@1|root,COG1028@2|Bacteria,1N907@1224|Proteobacteria,1RSMN@1236|Gammaproteobacteria,1Z5UU@136849|Pseudomonas syringae group	1236|Gammaproteobacteria	IQ	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	IV02_09705	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HKD2_k127_2708597_0	485913.Krac_7493	2.112e-87	308.0	COG2203@1|root,COG2508@1|root,COG3605@1|root,COG2203@2|Bacteria,COG2508@2|Bacteria,COG3605@2|Bacteria,2G67M@200795|Chloroflexi	2|Bacteria	T	PFAM GAF domain protein	-	-	4.1.2.17	ko:K01628,ko:K03406,ko:K21009	ko00051,ko01120,ko02020,ko02025,ko02030,map00051,map01120,map02020,map02025,map02030	-	R02262	RC00603,RC00604	ko00000,ko00001,ko01000,ko02035	-	-	-	GAF,GAF_2,HATPase_c,HTH_30,HisKA,MCPsignal,PAS,PAS_3,PAS_4,PAS_9,Response_reg
HKD2_k127_2708597_1	485913.Krac_2679	1.202e-53	196.0	COG5001@1|root,COG5001@2|Bacteria	2|Bacteria	T	cyclic-guanylate-specific phosphodiesterase activity	-	-	-	-	-	-	-	-	-	-	-	-	CHASE,EAL,GGDEF,HATPase_c,PAS_3,PAS_4,PAS_9,TPR_12,dCache_1
HKD2_k127_2712832_2	485913.Krac_1345	4.367e-54	191.0	COG3536@1|root,COG3536@2|Bacteria,2G7H1@200795|Chloroflexi	200795|Chloroflexi	S	Protein of unknown function (DUF971)	-	-	-	-	-	-	-	-	-	-	-	-	DUF971
HKD2_k127_2712832_1	1382306.JNIM01000001_gene2482	5.662e-84	287.0	COG3662@1|root,COG3662@2|Bacteria,2G8VS@200795|Chloroflexi	200795|Chloroflexi	S	Uncharacterized protein conserved in bacteria (DUF2236)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2236
HKD2_k127_2712832_0	485913.Krac_1343	4.975e-101	340.0	COG0300@1|root,COG0300@2|Bacteria,2G8ZQ@200795|Chloroflexi	200795|Chloroflexi	S	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HKD2_k127_2721940_3	1382306.JNIM01000001_gene2663	2.691e-37	143.0	COG1316@1|root,COG1316@2|Bacteria	2|Bacteria	K	TRANSCRIPTIONal	-	-	-	-	-	-	-	-	-	-	-	-	LytR_cpsA_psr
HKD2_k127_2721940_2	314278.NB231_07110	5.146e-91	313.0	COG3287@1|root,COG3287@2|Bacteria,1R825@1224|Proteobacteria	1224|Proteobacteria	S	PFAM FIST C domain	-	-	-	-	-	-	-	-	-	-	-	-	FIST,FIST_C
HKD2_k127_2721940_1	1382306.JNIM01000001_gene2665	2.643e-127	417.0	COG0460@1|root,COG0460@2|Bacteria,2G6PU@200795|Chloroflexi	200795|Chloroflexi	E	homoserine dehydrogenase	metM	-	1.1.1.3	ko:K00003	ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00017,M00018	R01773,R01775	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,Homoserine_dh,NAD_binding_3
HKD2_k127_2721940_0	485913.Krac_10596	1.428e-260	825.0	COG0728@1|root,COG0728@2|Bacteria,2G5MD@200795|Chloroflexi	200795|Chloroflexi	S	Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane	murJ	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
HKD2_k127_2750149_1	1382306.JNIM01000001_gene3792	1.132e-75	259.0	COG0515@1|root,COG0683@1|root,COG0515@2|Bacteria,COG0683@2|Bacteria,2G5NM@200795|Chloroflexi	2|Bacteria	KLT	Serine threonine protein kinase	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6,Pkinase
HKD2_k127_2750149_0	485913.Krac_12053	3.572e-270	859.0	COG0515@1|root,COG0515@2|Bacteria,2G5NM@200795|Chloroflexi	200795|Chloroflexi	KLT	Serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_6,Pkinase
HKD2_k127_2769555_3	485913.Krac_6806	3.92e-32	126.0	COG0718@1|root,COG0718@2|Bacteria	2|Bacteria	S	YbaB/EbfC DNA-binding family	yaaK	-	-	ko:K09747	-	-	-	-	ko00000	-	-	-	YbaB_DNA_bd
HKD2_k127_2769555_0	485913.Krac_6807	8.12e-226	721.0	COG2812@1|root,COG2812@2|Bacteria,2G5PK@200795|Chloroflexi	200795|Chloroflexi	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity	dnaX	-	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNA_pol3_gamma3
HKD2_k127_2769555_1	485913.Krac_6810	3.598e-139	447.0	COG0005@1|root,COG0005@2|Bacteria,2G5JP@200795|Chloroflexi	200795|Chloroflexi	F	Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates	mtnP	-	2.4.2.28	ko:K00772	ko00270,ko01100,map00270,map01100	M00034	R01402	RC00063,RC02819	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
HKD2_k127_2769555_2	485913.Krac_6811	2.903e-34	133.0	COG0162@1|root,COG0162@2|Bacteria,2G64J@200795|Chloroflexi	200795|Chloroflexi	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	-	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	S4,tRNA-synt_1b
HKD2_k127_2773307_1	1382306.JNIM01000001_gene853	4.771e-17	82.0	COG1304@1|root,COG1304@2|Bacteria,2G84G@200795|Chloroflexi	200795|Chloroflexi	C	FMN-dependent dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_dh
HKD2_k127_2773307_0	395961.Cyan7425_4133	1.434e-241	771.0	COG0474@1|root,COG0474@2|Bacteria,1G0JX@1117|Cyanobacteria,3KGUQ@43988|Cyanothece	1117|Cyanobacteria	P	TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.2,3.6.3.8	ko:K01531,ko:K01537,ko:K12952	-	-	-	-	ko00000,ko01000	3.A.3.2,3.A.3.23,3.A.3.4	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
HKD2_k127_2791296_2	485913.Krac_6670	9.927e-58	201.0	2CJPB@1|root,33JM7@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2791296_1	485913.Krac_6669	5.189e-122	393.0	COG2197@1|root,COG2197@2|Bacteria,2G6PA@200795|Chloroflexi	200795|Chloroflexi	K	Response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HKD2_k127_2791296_0	1382306.JNIM01000001_gene1046	1.149e-145	470.0	COG4585@1|root,COG4585@2|Bacteria,2G6F0@200795|Chloroflexi	200795|Chloroflexi	T	histidine kinase, dimerisation and phosphoacceptor region	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA_3,sCache_3_2
HKD2_k127_2795291_0	485913.Krac_8453	1.386e-224	706.0	COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,2G5Y8@200795|Chloroflexi	200795|Chloroflexi	H	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	-	4.2.1.136,5.1.99.6	ko:K17758,ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	Carb_kinase,YjeF_N
HKD2_k127_2795291_2	485913.Krac_8454	1.282e-66	233.0	COG0359@1|root,COG0359@2|Bacteria,2G6V2@200795|Chloroflexi	200795|Chloroflexi	J	Binds to the 23S rRNA	rplI	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02939	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L9_C,Ribosomal_L9_N
HKD2_k127_2795291_3	485913.Krac_8455	7.328e-44	168.0	COG3427@1|root,COG3427@2|Bacteria,2G6U6@200795|Chloroflexi	2|Bacteria	NU	PFAM carbon monoxide dehydrogenase subunit G	-	-	-	ko:K09386	-	-	-	-	ko00000	-	-	-	COXG
HKD2_k127_2795291_1	485913.Krac_8456	3.376e-155	499.0	COG0349@1|root,COG0349@2|Bacteria,2G74K@200795|Chloroflexi	200795|Chloroflexi	L	3'-5' exonuclease	-	-	3.1.13.5	ko:K03684	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DNA_pol_A_exo1,HRDC
HKD2_k127_2815364_0	485913.Krac_8625	9.594e-187	587.0	COG0843@1|root,COG0843@2|Bacteria,2G5XS@200795|Chloroflexi	200795|Chloroflexi	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	-	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
HKD2_k127_2815364_1	485913.Krac_8626	2.137e-52	189.0	COG1622@1|root,COG2010@1|root,COG1622@2|Bacteria,COG2010@2|Bacteria,2G6C0@200795|Chloroflexi	200795|Chloroflexi	C	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)	-	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2,COX2_TM,Cytochrom_C
HKD2_k127_2821976_3	1382306.JNIM01000001_gene962	1.718e-34	133.0	COG1197@1|root,COG1197@2|Bacteria,2G5UW@200795|Chloroflexi	200795|Chloroflexi	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
HKD2_k127_2821976_0	485913.Krac_7621	3.557e-242	769.0	COG3463@1|root,COG3463@2|Bacteria,2G8G9@200795|Chloroflexi	200795|Chloroflexi	S	Predicted membrane protein (DUF2079)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2079
HKD2_k127_2821976_1	1382306.JNIM01000001_gene958	5.578e-108	360.0	COG0392@1|root,COG0392@2|Bacteria,2G96U@200795|Chloroflexi	200795|Chloroflexi	S	Lysylphosphatidylglycerol synthase TM region	-	-	-	ko:K07027	-	-	-	-	ko00000,ko02000	4.D.2	-	-	LPG_synthase_TM
HKD2_k127_2821976_5	1382306.JNIM01000001_gene957	1.864e-21	94.0	COG0463@1|root,COG0463@2|Bacteria,2G5X5@200795|Chloroflexi	200795|Chloroflexi	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HKD2_k127_2828609_1	118168.MC7420_794	3.408e-116	377.0	COG3957@1|root,COG3957@2|Bacteria,1G0B2@1117|Cyanobacteria,1H7CT@1150|Oscillatoriales	1117|Cyanobacteria	G	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase	xfp	-	4.1.2.22,4.1.2.9	ko:K01621	ko00030,ko00710,ko01100,ko01120,map00030,map00710,map01100,map01120	-	R00761,R01621	RC00032,RC00226	ko00000,ko00001,ko01000	-	-	-	XFP,XFP_C,XFP_N
HKD2_k127_2828609_0	485913.Krac_11829	9.865e-169	539.0	COG0282@1|root,COG0282@2|Bacteria	2|Bacteria	F	acetate kinase activity	ackA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	2.7.2.1	ko:K00925	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00315,R01353	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv0409	Acetate_kinase
HKD2_k127_2849089_2	1382306.JNIM01000001_gene113	3.335e-18	85.0	COG1234@1|root,COG1234@2|Bacteria	2|Bacteria	L	tRNA 3'-trailer cleavage	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
HKD2_k127_2849089_0	485913.Krac_11874	1.75e-59	210.0	COG3981@1|root,COG3981@2|Bacteria	2|Bacteria	S	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_3
HKD2_k127_2849089_1	485913.Krac_1919	9.616e-45	181.0	2DVKJ@1|root,33W9U@2|Bacteria	2|Bacteria	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
HKD2_k127_2855774_7	485913.Krac_7647	5.242e-19	89.0	COG0828@1|root,COG0828@2|Bacteria,2G7EY@200795|Chloroflexi	200795|Chloroflexi	J	Belongs to the bacterial ribosomal protein bS21 family	rpsU	-	-	ko:K02970	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S21
HKD2_k127_2855774_3	485913.Krac_7648	7.964e-73	249.0	COG0319@1|root,COG0319@2|Bacteria,2G78D@200795|Chloroflexi	200795|Chloroflexi	J	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA	ybeY	-	-	ko:K07042	-	-	-	-	ko00000,ko03009	-	-	-	UPF0054
HKD2_k127_2855774_6	1382306.JNIM01000001_gene1389	7.331e-40	151.0	COG0818@1|root,COG0818@2|Bacteria,2G75I@200795|Chloroflexi	200795|Chloroflexi	M	PFAM diacylglycerol kinase	-	-	2.7.1.107	ko:K00901	ko00561,ko00564,ko01100,ko01110,ko04070,ko04072,ko05231,map00561,map00564,map01100,map01110,map04070,map04072,map05231	-	R02240	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	DAGK_prokar
HKD2_k127_2855774_1	485913.Krac_7652	1.57e-98	328.0	2ASZS@1|root,31IFG@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2
HKD2_k127_2855774_5	485913.Krac_7656	4.698e-52	192.0	COG0789@1|root,COG0789@2|Bacteria	2|Bacteria	K	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	MerR_1
HKD2_k127_2855774_0	1382306.JNIM01000001_gene1379	2.592e-162	524.0	COG0477@1|root,COG2814@2|Bacteria,2G6D7@200795|Chloroflexi	200795|Chloroflexi	EGP	Major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
HKD2_k127_2855774_2	485913.Krac_7658	3.107e-92	309.0	COG0095@1|root,COG0095@2|Bacteria,2G908@200795|Chloroflexi	200795|Chloroflexi	H	Lipoate-protein ligase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2855774_4	485913.Krac_7659	1.207e-58	206.0	COG2120@1|root,COG2120@2|Bacteria,2G6FB@200795|Chloroflexi	200795|Chloroflexi	S	PFAM LmbE family protein	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
HKD2_k127_2858743_3	485913.Krac_8104	1.76e-10	61.0	COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,2G816@200795|Chloroflexi	200795|Chloroflexi	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3
HKD2_k127_2858743_1	485913.Krac_2804	3.914e-94	325.0	COG0631@1|root,COG0631@2|Bacteria,2G8RD@200795|Chloroflexi	2|Bacteria	T	SMART protein phosphatase 2C domain protein	-	-	3.1.3.16	ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C,PP2C_2
HKD2_k127_2859286_1	481448.Minf_2155	3.408e-40	152.0	COG2210@1|root,COG2210@2|Bacteria,46ZAV@74201|Verrucomicrobia,37GMZ@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	S	DsrE/DsrF-like family	-	-	-	-	-	-	-	-	-	-	-	-	DrsE_2
HKD2_k127_2859286_0	1382306.JNIM01000001_gene3598	6.432e-47	173.0	COG3439@1|root,COG3439@2|Bacteria,2G72I@200795|Chloroflexi	200795|Chloroflexi	S	Domain of unknown function DUF302	-	-	-	-	-	-	-	-	-	-	-	-	DUF302
HKD2_k127_2859286_2	1220582.RRU01S_23_01170	3.345e-36	139.0	COG1472@1|root,COG1472@2|Bacteria,1MVIV@1224|Proteobacteria,2TS28@28211|Alphaproteobacteria,4BAYC@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	Belongs to the glycosyl hydrolase 3 family	-	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C,PA14
HKD2_k127_2861344_1	1382306.JNIM01000001_gene77	2.271e-134	431.0	COG1003@1|root,COG1003@2|Bacteria,2G5MU@200795|Chloroflexi	200795|Chloroflexi	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPB	-	1.4.4.2	ko:K00281,ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko00002,ko01000	-	-	-	GDC-P
HKD2_k127_2861344_0	485913.Krac_8785	6.783e-222	695.0	COG0403@1|root,COG0403@2|Bacteria,2G5NI@200795|Chloroflexi	200795|Chloroflexi	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPA	-	1.4.4.2	ko:K00282	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	-	GDC-P
HKD2_k127_2861344_2	485913.Krac_8784	2.355e-58	205.0	COG0509@1|root,COG0509@2|Bacteria,2G6XE@200795|Chloroflexi	200795|Chloroflexi	E	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	gcvH	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
HKD2_k127_2872011_1	485913.Krac_6741	4.214e-125	405.0	COG0769@1|root,COG0769@2|Bacteria,2G5U3@200795|Chloroflexi	200795|Chloroflexi	M	Catalyzes the addition of an amino acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan	murE	-	6.3.2.13	ko:K01928	ko00300,ko00550,map00300,map00550	-	R02788	RC00064,RC00090	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
HKD2_k127_2872011_0	1382306.JNIM01000001_gene2551	1.314e-136	442.0	KOG2524@1|root,2ZJ84@2|Bacteria,2G826@200795|Chloroflexi	200795|Chloroflexi	S	Potential Queuosine, Q, salvage protein family	-	-	-	-	-	-	-	-	-	-	-	-	Q_salvage
HKD2_k127_2873637_1	1382306.JNIM01000001_gene4143	3.21e-49	177.0	COG0634@1|root,COG0634@2|Bacteria,2G6HX@200795|Chloroflexi	200795|Chloroflexi	F	Belongs to the purine pyrimidine phosphoribosyltransferase family	-	-	2.4.2.8	ko:K00760	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	-	R00190,R01132,R01229,R02142,R08237,R08238,R08245	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	Pribosyltran
HKD2_k127_2873637_0	392499.Swit_3414	7.457e-130	418.0	COG1878@1|root,COG1878@2|Bacteria,1MV8S@1224|Proteobacteria,2TSUJ@28211|Alphaproteobacteria,2K01S@204457|Sphingomonadales	204457|Sphingomonadales	S	Putative cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Cyclase
HKD2_k127_2876094_2	485913.Krac_7569	1.458e-75	261.0	COG3540@1|root,COG3540@2|Bacteria,2G9SZ@200795|Chloroflexi	200795|Chloroflexi	P	Alkaline phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2876094_1	1382306.JNIM01000001_gene1025	6.306e-204	641.0	COG1541@1|root,COG1541@2|Bacteria,2G695@200795|Chloroflexi	200795|Chloroflexi	H	AMP-binding enzyme	-	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C_2
HKD2_k127_2876094_0	485913.Krac_9363	6.86e-316	981.0	COG1529@1|root,COG1529@2|Bacteria,2G608@200795|Chloroflexi	200795|Chloroflexi	C	aldehyde oxidase and xanthine dehydrogenase, a b hammerhead	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
HKD2_k127_2878783_1	272562.CA_C2347	9.603e-13	79.0	COG1216@1|root,COG1216@2|Bacteria,1V06G@1239|Firmicutes,247WU@186801|Clostridia,36GAS@31979|Clostridiaceae	186801|Clostridia	H	glycosyl transferase family	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2,Methyltransf_23
HKD2_k127_2878783_0	1382306.JNIM01000001_gene2670	1.415e-208	655.0	COG1164@1|root,COG1164@2|Bacteria,2G60A@200795|Chloroflexi	200795|Chloroflexi	E	PFAM peptidase M3A and M3B, thimet oligopeptidase F	-	-	-	ko:K08602	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3,Peptidase_M3_N
HKD2_k127_2882118_0	1382306.JNIM01000001_gene129	8.41e-97	321.0	COG2386@1|root,COG2386@2|Bacteria,2G6TN@200795|Chloroflexi	200795|Chloroflexi	O	PFAM cytochrome c-type biogenesis protein CcmB	ccmB	-	-	ko:K02194	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.107	-	-	CcmB
HKD2_k127_2882118_1	1382306.JNIM01000001_gene128	2.423e-94	315.0	COG0755@1|root,COG0755@2|Bacteria,2G6SI@200795|Chloroflexi	200795|Chloroflexi	O	PFAM Cytochrome C assembly protein	ccmC	-	-	ko:K02195	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.107	-	-	Cytochrom_C_asm
HKD2_k127_2882118_3	1382306.JNIM01000001_gene126	1.09e-06	53.0	arCOG03922@1|root,33G2Q@2|Bacteria,2G9KY@200795|Chloroflexi	200795|Chloroflexi	S	Protein of unknown function (DUF3054)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3054
HKD2_k127_2888752_0	697282.Mettu_3896	1.604e-109	365.0	COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,1RQ7D@1236|Gammaproteobacteria,1XDVZ@135618|Methylococcales	135618|Methylococcales	F	PFAM Asparagine synthase	-	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
HKD2_k127_2888752_1	1499967.BAYZ01000123_gene2532	1.905e-36	144.0	COG0367@1|root,COG0367@2|Bacteria,2NNKE@2323|unclassified Bacteria	2|Bacteria	E	PFAM asparagine synthase	asnB	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
HKD2_k127_2892661_1	485913.Krac_12160	9.995e-89	296.0	COG1695@1|root,COG1695@2|Bacteria,2G9N5@200795|Chloroflexi	200795|Chloroflexi	K	Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	PadR,Vir_act_alpha_C
HKD2_k127_2892661_0	1382306.JNIM01000001_gene310	4.138e-117	382.0	COG1396@1|root,COG1396@2|Bacteria	2|Bacteria	K	sequence-specific DNA binding	MA20_08830	-	-	-	-	-	-	-	-	-	-	-	HTH_3,HTH_31
HKD2_k127_2892661_2	485913.Krac_12199	2.206e-69	239.0	COG0318@1|root,COG0318@2|Bacteria,2G5Q8@200795|Chloroflexi	200795|Chloroflexi	IQ	PFAM AMP-dependent synthetase and ligase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
HKD2_k127_2900310_1	485913.Krac_8231	7.836e-193	608.0	COG0003@1|root,COG0003@2|Bacteria,2G64V@200795|Chloroflexi	200795|Chloroflexi	P	PFAM Anion-transporting ATPase	-	-	3.6.3.16	ko:K01551	-	-	-	-	ko00000,ko01000,ko02000	3.A.19.1,3.A.21.1,3.A.4.1	-	-	ArsA_ATPase
HKD2_k127_2900310_0	485913.Krac_8234	7.355e-281	880.0	COG1200@1|root,COG1200@2|Bacteria,2G5YM@200795|Chloroflexi	200795|Chloroflexi	L	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)	recG	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge
HKD2_k127_2905049_1	485913.Krac_8419	8.898e-111	363.0	COG1363@1|root,COG1363@2|Bacteria,2G5WS@200795|Chloroflexi	200795|Chloroflexi	G	peptidase M42 family protein	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M42
HKD2_k127_2905049_0	1382306.JNIM01000001_gene3764	1.524e-216	679.0	COG0277@1|root,COG0277@2|Bacteria,2G8B5@200795|Chloroflexi	200795|Chloroflexi	C	PFAM FAD linked oxidase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_4
HKD2_k127_2905049_2	485913.Krac_8275	1.974e-09	59.0	COG0300@1|root,COG0300@2|Bacteria,2G7XW@200795|Chloroflexi	200795|Chloroflexi	S	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HKD2_k127_2908384_2	485913.Krac_8684	1.337e-150	481.0	COG0416@1|root,COG0416@2|Bacteria,2G5Z8@200795|Chloroflexi	200795|Chloroflexi	I	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA	plsX	-	2.3.1.15	ko:K03621	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FA_synthesis
HKD2_k127_2908384_6	485913.Krac_8683	5.488e-66	226.0	COG0745@1|root,COG0745@2|Bacteria,2G9KD@200795|Chloroflexi	200795|Chloroflexi	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
HKD2_k127_2908384_0	485913.Krac_8679	8.281e-189	595.0	COG1960@1|root,COG1960@2|Bacteria,2G7V9@200795|Chloroflexi	200795|Chloroflexi	C	Acyl-CoA dehydrogenase, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HKD2_k127_2908384_5	485913.Krac_2501	1.81e-67	234.0	2EC7T@1|root,3366B@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2908384_1	1382306.JNIM01000001_gene264	1.551e-184	580.0	COG3396@1|root,COG3396@2|Bacteria,2G9AI@200795|Chloroflexi	200795|Chloroflexi	S	PFAM phenylacetic acid catabolic family protein	-	-	1.14.13.149	ko:K02609	ko00360,ko01120,map00360,map01120	-	R09838	RC02690	ko00000,ko00001,ko01000	-	-	-	PaaA_PaaC
HKD2_k127_2908384_7	1382306.JNIM01000001_gene265	4.198e-55	195.0	COG2151@1|root,COG2151@2|Bacteria,2G9PR@200795|Chloroflexi	200795|Chloroflexi	S	Pfam:DUF59	-	-	-	ko:K02612	ko00360,ko01120,map00360,map01120	-	R09838	RC02690	ko00000,ko00001	-	-	-	FeS_assembly_P
HKD2_k127_2908384_8	485913.Krac_12221	1.327e-29	119.0	2DDXP@1|root,2ZJQF@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2908384_4	485913.Krac_12220	3.759e-116	378.0	COG3396@1|root,COG3396@2|Bacteria,2G9KQ@200795|Chloroflexi	200795|Chloroflexi	S	PFAM phenylacetic acid catabolic family protein	-	-	1.14.13.149	ko:K02611	ko00360,ko01120,map00360,map01120	-	R09838	RC02690	ko00000,ko00001,ko01000	-	-	-	PaaA_PaaC
HKD2_k127_2908384_3	485913.Krac_12218	8.608e-149	473.0	COG1024@1|root,COG1024@2|Bacteria,2G5JW@200795|Chloroflexi	200795|Chloroflexi	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	5.3.3.18	ko:K15866	ko00360,ko01120,map00360,map01120	-	R09837,R09839	RC00004,RC00326,RC02689,RC03003	ko00000,ko00001,ko01000	-	-	-	ECH_1
HKD2_k127_2914643_1	485913.Krac_12563	2.486e-23	105.0	COG1674@1|root,COG1674@2|Bacteria,2G5XC@200795|Chloroflexi	200795|Chloroflexi	D	PFAM cell divisionFtsK SpoIIIE	-	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
HKD2_k127_2914643_0	485913.Krac_12565	2.101e-310	957.0	COG0595@1|root,COG0595@2|Bacteria,2G611@200795|Chloroflexi	200795|Chloroflexi	S	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay	rnj	-	-	ko:K12574	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	Lactamase_B,RMMBL
HKD2_k127_2922008_0	485913.Krac_8870	4.955e-127	416.0	COG3842@1|root,COG3842@2|Bacteria	2|Bacteria	P	ATPase activity	modC	-	2.10.1.1,3.6.3.29,3.6.3.55	ko:K02017,ko:K02018,ko:K03750,ko:K15497	ko00790,ko01100,ko02010,map00790,map01100,map02010	M00189,M00423	R09735,R10531	RC00002,RC03462	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.6.5,3.A.1.8	-	-	ABC_tran,BPD_transp_1,TOBE
HKD2_k127_2922819_0	1536772.R70723_30360	1.778e-05	53.0	2DHHI@1|root,2ZZSX@2|Bacteria,1TYZA@1239|Firmicutes,4I85M@91061|Bacilli,26YYV@186822|Paenibacillaceae	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS66
HKD2_k127_29258_2	485913.Krac_10096	1.774e-51	185.0	COG3603@1|root,COG3603@2|Bacteria,2G92A@200795|Chloroflexi	200795|Chloroflexi	S	ACT domain	-	-	-	ko:K09707	-	-	-	-	ko00000	-	-	-	ACT_7
HKD2_k127_29258_1	102129.Lepto7375DRAFT_7767	5.122e-66	239.0	COG0457@1|root,COG2909@1|root,COG0457@2|Bacteria,COG2909@2|Bacteria,1G20P@1117|Cyanobacteria,1H8AZ@1150|Oscillatoriales	1117|Cyanobacteria	L	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_11,TPR_2,TPR_8
HKD2_k127_2944249_0	485913.Krac_10883	7.481e-63	224.0	COG3336@1|root,COG3336@2|Bacteria	2|Bacteria	G	cytochrome c oxidase	ctaG	-	-	ko:K02351,ko:K02862	-	-	-	-	ko00000	-	-	-	Caa3_CtaG
HKD2_k127_2944817_0	485913.Krac_10264	3.232e-98	334.0	COG5650@1|root,COG5650@2|Bacteria	2|Bacteria	M	phosphatidylinositol metabolic process	-	-	-	-	-	-	-	-	-	-	-	-	GT87
HKD2_k127_2944817_1	1163398.AJJP01000056_gene1943	1.258e-12	79.0	COG0129@1|root,COG0129@2|Bacteria,1MUTQ@1224|Proteobacteria,1RMP2@1236|Gammaproteobacteria	1236|Gammaproteobacteria	EG	Belongs to the IlvD Edd family	ilvD	-	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
HKD2_k127_2945155_2	485913.Krac_8419	7.31e-41	153.0	COG1363@1|root,COG1363@2|Bacteria,2G5WS@200795|Chloroflexi	200795|Chloroflexi	G	peptidase M42 family protein	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M42
HKD2_k127_2945155_0	485913.Krac_8418	2.968e-198	626.0	COG1432@1|root,COG1432@2|Bacteria	2|Bacteria	S	NYN domain	-	-	-	-	-	-	-	-	-	-	-	-	NYN
HKD2_k127_2945155_1	485913.Krac_8417	2.828e-49	177.0	COG1733@1|root,COG1733@2|Bacteria,2G792@200795|Chloroflexi	200795|Chloroflexi	K	PFAM helix-turn-helix HxlR type	-	-	-	-	-	-	-	-	-	-	-	-	HxlR
HKD2_k127_2946731_1	485913.Krac_6851	1.187e-71	245.0	COG0125@1|root,COG0125@2|Bacteria,2G6G2@200795|Chloroflexi	200795|Chloroflexi	F	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis	tmk	-	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylate_kin
HKD2_k127_2946731_0	485913.Krac_6852	1.186e-120	388.0	COG0717@1|root,COG0717@2|Bacteria	2|Bacteria	F	dUTP biosynthetic process	dcd	-	3.5.4.13	ko:K01494	ko00240,ko01100,map00240,map01100	M00053	R00568,R02325	RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	dUTPase
HKD2_k127_2946731_2	485913.Krac_6853	9.227e-21	93.0	COG0322@1|root,COG0847@1|root,COG0322@2|Bacteria,COG0847@2|Bacteria,2G7WZ@200795|Chloroflexi	200795|Chloroflexi	L	DNA polymerase III, epsilon subunit	-	-	2.7.7.7	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	GIY-YIG,RNase_T,UVR
HKD2_k127_2948155_0	485913.Krac_3176	2.987e-113	372.0	COG0395@1|root,COG0395@2|Bacteria,2G6H2@200795|Chloroflexi	200795|Chloroflexi	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02026,ko:K05815	ko02010,map02010	M00198,M00207	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.3	-	-	BPD_transp_1
HKD2_k127_2948155_1	485913.Krac_3175	3.188e-100	332.0	COG1175@1|root,COG1175@2|Bacteria,2G6TJ@200795|Chloroflexi	200795|Chloroflexi	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
HKD2_k127_2969212_1	485913.Krac_12107	2.395e-78	264.0	COG0315@1|root,COG0315@2|Bacteria,2G6PC@200795|Chloroflexi	200795|Chloroflexi	H	Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)	moaC	-	4.6.1.17	ko:K03637	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R11372	RC03425	ko00000,ko00001,ko01000	-	-	-	MoaC
HKD2_k127_297894_0	485913.Krac_2375	2.056e-62	216.0	COG1403@1|root,COG1403@2|Bacteria	2|Bacteria	V	endonuclease activity	-	-	-	-	-	-	-	-	-	-	-	-	RRXRR
HKD2_k127_297894_1	485913.Krac_5370	1.252e-58	211.0	COG1309@1|root,COG1309@2|Bacteria	485913.Krac_5370|-	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2989118_4	880072.Desac_0882	2.064e-06	51.0	COG3311@1|root,COG3311@2|Bacteria	2|Bacteria	K	DNA excision	-	-	-	ko:K02806	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	-	-	-	HTH_17,PTS_EIIA_2
HKD2_k127_2989118_2	485913.Krac_12315	1.909e-24	110.0	COG0582@1|root,COG0582@2|Bacteria,2G7XX@200795|Chloroflexi	200795|Chloroflexi	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_3,Phage_integrase
HKD2_k127_2989118_5	47839.CCAU010000009_gene1695	2.134e-05	52.0	COG0582@1|root,COG0582@2|Bacteria,2GMMI@201174|Actinobacteria,234F2@1762|Mycobacteriaceae	201174|Actinobacteria	L	Belongs to the 'phage' integrase family	int	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_3,Phage_integrase
HKD2_k127_2989118_0	485913.Krac_11918	1.464e-91	304.0	COG2316@1|root,COG2316@2|Bacteria,2G6T2@200795|Chloroflexi	200795|Chloroflexi	S	TIGRFAM metal dependent phophohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HD
HKD2_k127_2989118_3	1382306.JNIM01000001_gene2898	1.059e-07	57.0	COG1468@1|root,COG1468@2|Bacteria,2G6VA@200795|Chloroflexi	200795|Chloroflexi	L	Domain of unknown function DUF83	-	-	3.1.12.1	ko:K07464	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	Cas_Cas4
HKD2_k127_3000581_1	1382306.JNIM01000001_gene2315	2.199e-60	215.0	COG1309@1|root,COG1309@2|Bacteria,2G8WK@200795|Chloroflexi	200795|Chloroflexi	K	PFAM Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
HKD2_k127_3000581_0	485913.Krac_7493	1.129e-66	229.0	COG2203@1|root,COG2508@1|root,COG3605@1|root,COG2203@2|Bacteria,COG2508@2|Bacteria,COG3605@2|Bacteria,2G67M@200795|Chloroflexi	2|Bacteria	T	PFAM GAF domain protein	-	-	4.1.2.17	ko:K01628,ko:K03406,ko:K21009	ko00051,ko01120,ko02020,ko02025,ko02030,map00051,map01120,map02020,map02025,map02030	-	R02262	RC00603,RC00604	ko00000,ko00001,ko01000,ko02035	-	-	-	GAF,GAF_2,HATPase_c,HTH_30,HisKA,MCPsignal,PAS,PAS_3,PAS_4,PAS_9,Response_reg
HKD2_k127_3002311_2	1382306.JNIM01000001_gene993	2.049e-104	341.0	COG0377@1|root,COG0377@2|Bacteria	2|Bacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoB1	-	1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q6
HKD2_k127_3002311_0	1382306.JNIM01000001_gene451	2.589e-195	614.0	COG0649@1|root,COG0649@2|Bacteria,2G5JF@200795|Chloroflexi	200795|Chloroflexi	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoD	-	1.6.5.3	ko:K00333,ko:K13378	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa,Complex1_49kDa
HKD2_k127_3002311_1	1183438.GKIL_3693	2.445e-137	445.0	COG3569@1|root,COG3569@2|Bacteria,1G2R6@1117|Cyanobacteria	1117|Cyanobacteria	L	Eukaryotic DNA topoisomerase I, catalytic core	-	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_I
HKD2_k127_3003317_0	1382306.JNIM01000001_gene2694	8.483e-125	402.0	COG1529@1|root,COG1529@2|Bacteria,2G608@200795|Chloroflexi	200795|Chloroflexi	C	aldehyde oxidase and xanthine dehydrogenase, a b hammerhead	-	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
HKD2_k127_3003317_1	1382306.JNIM01000001_gene2695	1.548e-94	311.0	COG2080@1|root,COG2080@2|Bacteria,2G6NT@200795|Chloroflexi	200795|Chloroflexi	C	2Fe-2S -binding domain protein	-	-	1.2.5.3	ko:K03518	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Fer2,Fer2_2
HKD2_k127_3004243_0	497965.Cyan7822_1790	3.514e-102	350.0	COG4942@1|root,COG4942@2|Bacteria	2|Bacteria	D	peptidase	-	-	-	-	-	-	-	-	-	-	-	-	DUF3375
HKD2_k127_3011531_1	485913.Krac_10548	6.157e-134	454.0	COG0827@1|root,COG1002@1|root,COG0827@2|Bacteria,COG1002@2|Bacteria,2G84A@200795|Chloroflexi	200795|Chloroflexi	LV	Pfam:Methyltransf_26	-	-	-	-	-	-	-	-	-	-	-	-	Eco57I
HKD2_k127_3011531_0	485913.Krac_10920	4.654e-152	491.0	COG1508@1|root,COG1508@2|Bacteria,2G5VM@200795|Chloroflexi	200795|Chloroflexi	K	TIGRFAM RNA polymerase sigma-54 factor, RpoN	-	-	-	ko:K03092	ko02020,ko05111,map02020,map05111	-	-	-	ko00000,ko00001,ko03021	-	-	-	Sigma54_AID,Sigma54_CBD,Sigma54_DBD
HKD2_k127_3032148_1	485913.Krac_7641	2.117e-30	122.0	COG0008@1|root,COG0008@2|Bacteria,2G5WU@200795|Chloroflexi	200795|Chloroflexi	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
HKD2_k127_3032148_2	485913.Krac_7640	7.319e-28	115.0	COG0019@1|root,COG0019@2|Bacteria,2G5RR@200795|Chloroflexi	200795|Chloroflexi	E	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine	lysA	-	4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
HKD2_k127_3032148_0	1382306.JNIM01000001_gene1397	1.111e-76	260.0	COG1259@1|root,COG1259@2|Bacteria,2G6P6@200795|Chloroflexi	200795|Chloroflexi	S	Bifunctional nuclease	-	-	-	ko:K08999	-	-	-	-	ko00000	-	-	-	DNase-RNase
HKD2_k127_3039079_1	1033732.CAHI01000035_gene2765	0.0004335	46.0	COG4974@1|root,COG4974@2|Bacteria,4NGQW@976|Bacteroidetes,2FNFK@200643|Bacteroidia,22UDG@171550|Rikenellaceae	976|Bacteroidetes	D	Belongs to the 'phage' integrase family. XerC subfamily	xerC	-	-	ko:K03733	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
HKD2_k127_3039079_0	1382306.JNIM01000001_gene615	5.666e-134	431.0	COG3442@1|root,COG3442@2|Bacteria,2G6KU@200795|Chloroflexi	200795|Chloroflexi	H	PFAM CobB CobQ domain protein glutamine amidotransferase	-	-	-	-	-	-	-	-	-	-	-	-	GATase_3
HKD2_k127_3039079_2	485913.Krac_8023	0.0009645	43.0	COG4632@1|root,COG4632@2|Bacteria,2G8RE@200795|Chloroflexi	200795|Chloroflexi	G	Phosphodiester glycosidase	-	-	-	-	-	-	-	-	-	-	-	-	NAGPA
HKD2_k127_304529_2	1382306.JNIM01000001_gene704	2.026e-24	109.0	2DQ2F@1|root,334G7@2|Bacteria,2G92Q@200795|Chloroflexi	200795|Chloroflexi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_304529_1	1382306.JNIM01000001_gene702	8.916e-103	341.0	COG0596@1|root,COG0596@2|Bacteria,2G8JV@200795|Chloroflexi	200795|Chloroflexi	S	Ndr family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
HKD2_k127_304529_0	485913.Krac_11168	1.087e-172	544.0	COG0320@1|root,COG0320@2|Bacteria,2G5MH@200795|Chloroflexi	200795|Chloroflexi	H	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives	lipA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0016740,GO:0016782,GO:0016783,GO:0016992,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0070283,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576	2.8.1.8	ko:K03644	ko00785,ko01100,map00785,map01100	-	R07767,R07768	RC01978	ko00000,ko00001,ko01000	-	-	-	LIAS_N,Radical_SAM
HKD2_k127_3047185_1	1382306.JNIM01000001_gene660	9.972e-18	83.0	COG1131@1|root,COG1131@2|Bacteria,2G5RD@200795|Chloroflexi	200795|Chloroflexi	V	PFAM ABC transporter related	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
HKD2_k127_3047185_0	1382306.JNIM01000001_gene661	8.082e-120	392.0	COG0842@1|root,COG0842@2|Bacteria,2G6H9@200795|Chloroflexi	2|Bacteria	V	Transport permease protein	pedC	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
HKD2_k127_3047185_2	1469607.KK073768_gene4663	7.102e-12	69.0	COG3547@1|root,COG3547@2|Bacteria,1GA7N@1117|Cyanobacteria,1HTM7@1161|Nostocales	1117|Cyanobacteria	L	PFAM Transposase IS116 IS110 IS902 family	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
HKD2_k127_3050733_4	485913.Krac_8644	4.474e-13	72.0	COG1589@1|root,COG1589@2|Bacteria,2G7FV@200795|Chloroflexi	200795|Chloroflexi	D	Cell division protein FtsQ	ftsQ	-	-	ko:K03589	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036	-	-	-	FtsQ,POTRA_1
HKD2_k127_3050733_2	485913.Krac_8644	3.683e-80	275.0	COG1589@1|root,COG1589@2|Bacteria,2G7FV@200795|Chloroflexi	200795|Chloroflexi	D	Cell division protein FtsQ	ftsQ	-	-	ko:K03589	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036	-	-	-	FtsQ,POTRA_1
HKD2_k127_3050733_0	1382306.JNIM01000001_gene41	1.68e-232	723.0	COG0849@1|root,COG0849@2|Bacteria,2G5V5@200795|Chloroflexi	200795|Chloroflexi	D	Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring	ftsA	-	-	ko:K03590	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036,ko04812	-	-	-	FtsA,SHS2_FTSA
HKD2_k127_3050733_1	1382306.JNIM01000001_gene42	3.868e-186	593.0	COG0206@1|root,COG0206@2|Bacteria,2G5V2@200795|Chloroflexi	200795|Chloroflexi	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
HKD2_k127_3060776_1	1284352.AOIG01000007_gene2081	3.311e-30	131.0	COG3861@1|root,COG3861@2|Bacteria,1V71H@1239|Firmicutes,4IRSD@91061|Bacilli,276WN@186822|Paenibacillaceae	91061|Bacilli	S	Heat induced stress protein YflT	-	-	-	-	-	-	-	-	-	-	-	-	DUF2382,YflT
HKD2_k127_3060776_0	402777.KB235903_gene1217	2.587e-92	313.0	28KS2@1|root,2ZA9I@2|Bacteria,1G27K@1117|Cyanobacteria,1HA9W@1150|Oscillatoriales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3075710_0	485913.Krac_7645	1.309e-122	410.0	COG3307@1|root,COG3307@2|Bacteria,2G6TE@200795|Chloroflexi	200795|Chloroflexi	M	PFAM O-antigen polymerase	-	-	-	-	-	-	-	-	-	-	-	-	Wzy_C
HKD2_k127_3075710_1	485913.Krac_7643	5.956e-92	306.0	COG1266@1|root,COG1266@2|Bacteria	2|Bacteria	V	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
HKD2_k127_3075710_2	485913.Krac_7642	2.03e-08	56.0	2CKD9@1|root,333BQ@2|Bacteria,2G7BT@200795|Chloroflexi	200795|Chloroflexi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3095167_1	1382306.JNIM01000001_gene281	1.423e-130	421.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	rfaG	GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008194,GO:0008610,GO:0008653,GO:0008919,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0035251,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0046401,GO:0046527,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	-	ko:K02844	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT4	iSDY_1059.SDY_4061	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
HKD2_k127_3095167_0	1382306.JNIM01000001_gene280	2.867e-235	734.0	COG1449@1|root,COG1449@2|Bacteria	2|Bacteria	G	Belongs to the glycosyl hydrolase 57 family	-	-	3.2.1.1	ko:K01176,ko:K07405	ko00500,ko01100,ko04973,map00500,map01100,map04973	-	R02108,R02112,R11262	-	ko00000,ko00001,ko01000	-	GH13,GH57	-	Glyco_hydro_57
HKD2_k127_3110789_0	485913.Krac_8845	0.0	1376.0	COG0542@1|root,COG0542@2|Bacteria,2G5QU@200795|Chloroflexi	200795|Chloroflexi	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpB	-	-	ko:K03695	ko04213,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
HKD2_k127_3115585_1	485913.Krac_9977	5.125e-08	57.0	COG5650@1|root,COG5650@2|Bacteria	2|Bacteria	M	phosphatidylinositol metabolic process	-	-	-	-	-	-	-	-	-	-	-	-	GT87
HKD2_k127_3115585_0	1382306.JNIM01000001_gene3593	2.567e-228	713.0	COG1271@1|root,COG1271@2|Bacteria,2G5TR@200795|Chloroflexi	200795|Chloroflexi	C	PFAM cytochrome bd ubiquinol oxidase subunit I	-	-	1.10.3.14	ko:K00425	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	Cyt_bd_oxida_I
HKD2_k127_3117351_6	1382306.JNIM01000001_gene3771	5.867e-14	73.0	COG1253@1|root,COG1253@2|Bacteria,2G67V@200795|Chloroflexi	200795|Chloroflexi	S	CBS domain containing protein	-	-	-	ko:K03699	-	-	-	-	ko00000,ko02042	-	-	-	CBS,CorC_HlyC,DUF21
HKD2_k127_3117351_3	485913.Krac_4867	1.963e-46	169.0	COG1670@1|root,COG1670@2|Bacteria,2G8V1@200795|Chloroflexi	2|Bacteria	J	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_3,GNAT_acetyltran
HKD2_k127_3117351_5	485913.Krac_4867	9.543e-18	84.0	COG1670@1|root,COG1670@2|Bacteria,2G8V1@200795|Chloroflexi	2|Bacteria	J	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_3,GNAT_acetyltran
HKD2_k127_3117351_2	485913.Krac_11238	4.446e-47	174.0	COG4639@1|root,COG4639@2|Bacteria,2G94H@200795|Chloroflexi	200795|Chloroflexi	S	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_33
HKD2_k127_3117351_0	485913.Krac_11240	7.557e-199	624.0	COG1960@1|root,COG1960@2|Bacteria,2G5K3@200795|Chloroflexi	200795|Chloroflexi	C	PFAM acyl-CoA dehydrogenase domain protein	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HKD2_k127_3117351_1	1382306.JNIM01000001_gene2754	1.271e-191	604.0	COG0195@1|root,COG0195@2|Bacteria,2G5M5@200795|Chloroflexi	200795|Chloroflexi	K	Participates in both transcription termination and antitermination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KH_5,NusA_N,S1
HKD2_k127_3117351_4	485913.Krac_11246	2.035e-37	143.0	COG2740@1|root,COG2740@2|Bacteria,2G72H@200795|Chloroflexi	200795|Chloroflexi	K	Protein of unknown function (DUF448)	-	-	-	ko:K07742	-	-	-	-	ko00000	-	-	-	DUF448
HKD2_k127_3138464_4	156889.Mmc1_2906	1.233e-09	61.0	2E2ED@1|root,32XIY@2|Bacteria,1N2TC@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3138464_1	485913.Krac_6688	1.808e-74	254.0	COG1832@1|root,COG1832@2|Bacteria,2G6VU@200795|Chloroflexi	200795|Chloroflexi	S	PFAM CoA-binding domain protein	-	-	-	ko:K06929	-	-	-	-	ko00000	-	-	-	CoA_binding_2
HKD2_k127_3138464_2	1158602.I590_01178	1.013e-46	177.0	2C2FI@1|root,32T83@2|Bacteria,1VD45@1239|Firmicutes,4HKXA@91061|Bacilli	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3138464_0	485913.Krac_6692	1.431e-153	491.0	COG0673@1|root,COG0673@2|Bacteria,2G8FU@200795|Chloroflexi	200795|Chloroflexi	S	PFAM oxidoreductase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
HKD2_k127_3138464_3	485913.Krac_10356	1.724e-20	94.0	COG4974@1|root,COG4974@2|Bacteria	2|Bacteria	L	Belongs to the 'phage' integrase family	xerD	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_int_SAM_4,Phage_integrase
HKD2_k127_3139503_0	926550.CLDAP_09410	4.838e-88	305.0	COG2909@1|root,COG3899@1|root,COG2909@2|Bacteria,COG3899@2|Bacteria,2G80F@200795|Chloroflexi	200795|Chloroflexi	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GerE
HKD2_k127_3139503_1	485913.Krac_4510	1.245e-08	58.0	COG2909@1|root,COG3899@1|root,COG2909@2|Bacteria,COG3899@2|Bacteria,2G80F@200795|Chloroflexi	200795|Chloroflexi	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GerE
HKD2_k127_3177690_2	1382306.JNIM01000001_gene596	7.844e-14	74.0	COG0341@1|root,COG0341@2|Bacteria,2G696@200795|Chloroflexi	200795|Chloroflexi	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secF	-	-	ko:K03074	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
HKD2_k127_3177690_0	485913.Krac_8048	8.036e-191	605.0	COG0342@1|root,COG0342@2|Bacteria,2G5K5@200795|Chloroflexi	200795|Chloroflexi	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	-	-	ko:K03072	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
HKD2_k127_3177690_1	485913.Krac_8047	1.585e-47	173.0	COG1136@1|root,COG1136@2|Bacteria,2G8CR@200795|Chloroflexi	200795|Chloroflexi	V	COGs COG1136 ABC-type antimicrobial peptide transport system ATPase component	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD2_k127_3209873_0	485913.Krac_8555	4.898e-134	436.0	COG0500@1|root,COG0500@2|Bacteria	2|Bacteria	Q	methyltransferase activity	-	-	2.1.1.302	ko:K21377	-	-	-	-	ko00000,ko01000	-	-	-	Dimerisation2,Methyltransf_2
HKD2_k127_3209873_1	485913.Krac_8554	2.413e-89	302.0	COG0382@1|root,COG0382@2|Bacteria	2|Bacteria	H	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate	ubiA	-	-	-	-	-	-	-	-	-	-	-	UbiA
HKD2_k127_3211280_1	485913.Krac_9998	4.505e-63	217.0	COG1690@1|root,COG1690@2|Bacteria,2G5NT@200795|Chloroflexi	200795|Chloroflexi	S	Belongs to the RtcB family	rtcB	-	6.5.1.3	ko:K14415	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RtcB
HKD2_k127_3211280_0	1382306.JNIM01000001_gene3592	4.132e-85	287.0	COG1294@1|root,COG1294@2|Bacteria,2G67G@200795|Chloroflexi	200795|Chloroflexi	C	PFAM cytochrome bd ubiquinol oxidase subunit II	-	-	1.10.3.14	ko:K00426	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	Cyt_bd_oxida_II
HKD2_k127_3216231_0	1382306.JNIM01000001_gene2561	2.2e-236	738.0	COG3808@1|root,COG3808@2|Bacteria,2G5N7@200795|Chloroflexi	200795|Chloroflexi	C	Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
HKD2_k127_3219761_0	485913.Krac_11750	5.799e-300	934.0	COG2203@1|root,COG3605@1|root,COG3920@1|root,COG2203@2|Bacteria,COG3605@2|Bacteria,COG3920@2|Bacteria,2G67M@200795|Chloroflexi	200795|Chloroflexi	T	PFAM GAF domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HATPase_c,HATPase_c_2,HisKA_2
HKD2_k127_3219761_1	485913.Krac_11748	1.119e-111	368.0	COG0329@1|root,COG0329@2|Bacteria,2G6U3@200795|Chloroflexi	200795|Chloroflexi	H	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	-	-	3.5.4.22	ko:K21062	ko00330,map00330	-	R02280	RC00679	ko00000,ko00001,ko01000	-	-	-	DHDPS
HKD2_k127_3219761_2	485913.Krac_11747	4.494e-84	287.0	COG0484@1|root,COG0484@2|Bacteria	2|Bacteria	O	heat shock protein binding	-	-	-	ko:K03686,ko:K05801,ko:K17867	-	-	-	-	ko00000,ko03012,ko03029,ko03110	-	-	-	DnaJ,TerB
HKD2_k127_324972_0	485913.Krac_8929	2.567e-228	713.0	COG1012@1|root,COG1012@2|Bacteria,2G5JZ@200795|Chloroflexi	200795|Chloroflexi	C	Belongs to the aldehyde dehydrogenase family	-	-	1.2.1.3	ko:K00128,ko:K22187	ko00010,ko00040,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00040,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146,R11768	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
HKD2_k127_324972_1	485913.Krac_8930	2.992e-97	319.0	COG1158@1|root,COG1158@2|Bacteria,2G5UQ@200795|Chloroflexi	200795|Chloroflexi	K	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template	rho	-	-	ko:K03628	ko03018,map03018	-	-	-	ko00000,ko00001,ko03019,ko03021	-	-	-	ATP-synt_ab,Rho_N,Rho_RNA_bind
HKD2_k127_3250451_1	1382306.JNIM01000001_gene548	1.64e-23	107.0	COG0726@1|root,COG0726@2|Bacteria,2G6VJ@200795|Chloroflexi	200795|Chloroflexi	G	Polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
HKD2_k127_3250451_0	485913.Krac_8225	1.195e-247	771.0	COG1249@1|root,COG1249@2|Bacteria,2G5MR@200795|Chloroflexi	200795|Chloroflexi	C	Pyridine nucleotide-disulphide oxidoreductase dimerisation region	lpd	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
HKD2_k127_326039_0	485913.Krac_7707	4.609e-114	382.0	COG5635@1|root,COG5635@2|Bacteria	2|Bacteria	T	Nacht domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	NACHT,Pkinase
HKD2_k127_326039_2	402777.KB235903_gene1063	7.44e-17	85.0	2C1A8@1|root,32R8C@2|Bacteria,1G7IA@1117|Cyanobacteria,1HDSA@1150|Oscillatoriales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_326039_3	309801.trd_0535	8.084e-08	56.0	COG0789@1|root,COG0789@2|Bacteria,2G9H2@200795|Chloroflexi,27Z9B@189775|Thermomicrobia	189775|Thermomicrobia	L	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_17
HKD2_k127_326436_0	485913.Krac_8793	5.844e-89	297.0	COG1403@1|root,COG1403@2|Bacteria,2G6WV@200795|Chloroflexi	200795|Chloroflexi	L	SMART HNH nuclease	-	-	-	-	-	-	-	-	-	-	-	-	HNH_5
HKD2_k127_326436_1	485913.Krac_8794	4.556e-33	130.0	COG1449@1|root,COG1449@2|Bacteria,2G5XB@200795|Chloroflexi	200795|Chloroflexi	G	Belongs to the glycosyl hydrolase 57 family	-	-	-	-	-	-	-	-	-	-	-	-	DUF3536,Glyco_hydro_57
HKD2_k127_3264656_0	485913.Krac_9804	7.407e-277	862.0	COG0488@1|root,COG0488@2|Bacteria,2G5VD@200795|Chloroflexi	200795|Chloroflexi	S	PFAM ABC transporter related	-	-	-	ko:K06158	-	-	-	-	ko00000,ko03012	-	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
HKD2_k127_3271043_0	485913.Krac_10951	5.765e-174	550.0	COG0476@1|root,COG0476@2|Bacteria,2G5Q1@200795|Chloroflexi	200795|Chloroflexi	H	ThiF family	-	-	2.7.7.80	ko:K21029	ko04122,map04122	-	R07459	RC00043	ko00000,ko00001,ko01000	-	-	-	ThiF
HKD2_k127_3271043_1	485913.Krac_10950	2.072e-74	254.0	COG0745@1|root,COG0745@2|Bacteria	485913.Krac_10950|-	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3272738_1	1382306.JNIM01000001_gene2532	1.379e-65	230.0	COG0518@1|root,COG0518@2|Bacteria	2|Bacteria	F	GMP synthase (glutamine-hydrolyzing) activity	guaA2	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase
HKD2_k127_3272738_0	485913.Krac_6717	6.387e-95	319.0	COG0631@1|root,COG0631@2|Bacteria	2|Bacteria	T	protein serine/threonine phosphatase activity	-	-	3.1.3.16	ko:K01090,ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C,PP2C_2
HKD2_k127_3276233_1	485913.Krac_9042	2.467e-118	382.0	COG0377@1|root,COG0377@2|Bacteria,2G6GB@200795|Chloroflexi	200795|Chloroflexi	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoB1	-	1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q6
HKD2_k127_3276233_2	485913.Krac_9043	1.217e-107	351.0	COG0852@1|root,COG0852@2|Bacteria,2G6WD@200795|Chloroflexi	200795|Chloroflexi	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoC	-	1.6.5.3	ko:K00332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa
HKD2_k127_3276233_0	485913.Krac_9044	4.259e-230	717.0	COG0649@1|root,COG0649@2|Bacteria,2G5MM@200795|Chloroflexi	200795|Chloroflexi	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoD	-	1.6.5.3	ko:K00333	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa
HKD2_k127_3276233_3	1382306.JNIM01000001_gene3468	5.733e-10	59.0	COG1905@1|root,COG1905@2|Bacteria,2G70Y@200795|Chloroflexi	200795|Chloroflexi	C	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit	-	-	1.6.5.3	ko:K00334	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
HKD2_k127_329912_0	485913.Krac_12597	3.792e-214	677.0	COG0477@1|root,COG2814@2|Bacteria,2G5SP@200795|Chloroflexi	200795|Chloroflexi	P	PFAM major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
HKD2_k127_329912_1	485913.Krac_12312	9.65e-19	86.0	COG0730@1|root,COG0730@2|Bacteria,2G6RC@200795|Chloroflexi	200795|Chloroflexi	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
HKD2_k127_3301146_0	485913.Krac_2807	4.803e-125	415.0	COG0697@1|root,COG0697@2|Bacteria	2|Bacteria	EG	spore germination	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HKD2_k127_3301146_1	485913.Krac_0816	9.116e-77	263.0	2EW5I@1|root,33PIN@2|Bacteria,2G7RP@200795|Chloroflexi	200795|Chloroflexi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3303253_0	485913.Krac_11237	3.989e-165	530.0	COG1253@1|root,COG1253@2|Bacteria,2G67V@200795|Chloroflexi	200795|Chloroflexi	S	CBS domain containing protein	-	-	-	ko:K03699	-	-	-	-	ko00000,ko02042	-	-	-	CBS,CorC_HlyC,DUF21
HKD2_k127_3303253_1	485913.Krac_4867	2.446e-12	67.0	COG1670@1|root,COG1670@2|Bacteria,2G8V1@200795|Chloroflexi	2|Bacteria	J	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_3,GNAT_acetyltran
HKD2_k127_3304582_2	485913.Krac_7555	6.722e-117	377.0	COG0493@1|root,COG0493@2|Bacteria,2G82F@200795|Chloroflexi	200795|Chloroflexi	C	4fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Complex1_30kDa,Fer2_4,Fer4,Fer4_20,Pyr_redox_2
HKD2_k127_3304582_0	485913.Krac_7556	4.8e-218	683.0	COG1894@1|root,COG1894@2|Bacteria,2G5K9@200795|Chloroflexi	200795|Chloroflexi	C	PFAM Respiratory-chain NADH dehydrogenase domain, 51 kDa subunit	hoxF	-	1.6.5.3	ko:K00335,ko:K05587	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx,Complex1_51K,Fer4,NADH_4Fe-4S,SLBB
HKD2_k127_3304582_1	1382306.JNIM01000001_gene994	1.004e-136	437.0	COG1143@1|root,COG1143@2|Bacteria	2|Bacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	echF	-	1.6.5.3	ko:K00338,ko:K14091	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer4,Fer4_10,Fer4_7
HKD2_k127_3304582_3	485913.Krac_7558	2.207e-45	164.0	COG0377@1|root,COG0377@2|Bacteria	2|Bacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoB1	-	1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q6
HKD2_k127_3336558_0	1382306.JNIM01000001_gene1834	1.744e-109	370.0	COG1807@1|root,COG1807@2|Bacteria,2G991@200795|Chloroflexi	200795|Chloroflexi	M	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3342415_0	485913.Krac_3682	1.487e-119	387.0	COG0673@1|root,COG0673@2|Bacteria,2G7RI@200795|Chloroflexi	200795|Chloroflexi	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
HKD2_k127_3342415_1	485913.Krac_11835	5.193e-74	259.0	COG1595@1|root,COG1595@2|Bacteria,2G6T5@200795|Chloroflexi	200795|Chloroflexi	K	PFAM sigma-70 region 2 domain protein	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD2_k127_33568_1	485913.Krac_11296	4.754e-128	420.0	COG0665@1|root,COG0665@2|Bacteria,2G80C@200795|Chloroflexi	200795|Chloroflexi	C	PFAM FAD dependent oxidoreductase	-	-	1.5.3.1	ko:K00301	ko00260,ko01100,map00260,map01100	-	R00610	RC00060,RC00557	ko00000,ko00001,ko01000	-	-	-	DAO
HKD2_k127_33568_0	485913.Krac_11295	7.227e-189	599.0	COG0128@1|root,COG0128@2|Bacteria,2G6S6@200795|Chloroflexi	200795|Chloroflexi	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	-	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	EPSP_synthase
HKD2_k127_3368926_0	1382306.JNIM01000001_gene3558	8.967e-168	531.0	COG0031@1|root,COG0031@2|Bacteria,2G5PG@200795|Chloroflexi	200795|Chloroflexi	E	Belongs to the cysteine synthase cystathionine beta- synthase family	cysK	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HKD2_k127_3368926_1	1382306.JNIM01000001_gene3559	4.969e-35	134.0	COG0745@1|root,COG0745@2|Bacteria	1382306.JNIM01000001_gene3559|-	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3374588_2	485913.Krac_12176	2.377e-87	296.0	COG0850@1|root,COG0850@2|Bacteria,2G6VN@200795|Chloroflexi	200795|Chloroflexi	D	Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization	minC	-	-	ko:K03610	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	MinC_C,MinC_N
HKD2_k127_3374588_0	485913.Krac_12175	1.652e-155	494.0	COG2894@1|root,COG2894@2|Bacteria,2G5YF@200795|Chloroflexi	200795|Chloroflexi	D	Belongs to the ParA family	minD	-	-	ko:K03609	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31,CbiA
HKD2_k127_3374588_3	485913.Krac_12174	3.887e-38	146.0	COG0851@1|root,COG0851@2|Bacteria,2G7FM@200795|Chloroflexi	200795|Chloroflexi	D	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell	minE	-	-	ko:K03608	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	MinE
HKD2_k127_3374588_1	485913.Krac_12172	1.19e-96	322.0	COG0346@1|root,COG0346@2|Bacteria,2G9NJ@200795|Chloroflexi	200795|Chloroflexi	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	1.13.11.2	ko:K00446	ko00361,ko00362,ko00622,ko00643,ko01100,ko01120,ko01220,map00361,map00362,map00622,map00643,map01100,map01120,map01220	M00569	R00816,R04089,R05295,R05404,R05406,R07795	RC00387,RC00643,RC01075,RC01364,RC01914	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	Glyoxalase
HKD2_k127_3382328_3	1382306.JNIM01000001_gene356	5.389e-154	499.0	COG0744@1|root,COG0744@2|Bacteria,2G5ZG@200795|Chloroflexi	200795|Chloroflexi	M	PFAM glycosyl transferase, family 51	-	-	-	-	-	-	-	-	-	-	-	-	BiPBP_C,Transgly,Transpeptidase
HKD2_k127_3382328_2	485913.Krac_8356	3.262e-165	525.0	COG1420@1|root,COG1420@2|Bacteria,2G6AQ@200795|Chloroflexi	200795|Chloroflexi	K	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons	hrcA	-	-	ko:K03705	-	-	-	-	ko00000,ko03000	-	-	-	HrcA
HKD2_k127_3382328_0	485913.Krac_8355	0.0	1108.0	COG0443@1|root,COG0443@2|Bacteria,2G5U5@200795|Chloroflexi	2|Bacteria	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
HKD2_k127_3382328_4	401526.TcarDRAFT_1254	1.885e-130	426.0	COG0484@1|root,COG0484@2|Bacteria,1TP00@1239|Firmicutes,4H28A@909932|Negativicutes	909932|Negativicutes	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
HKD2_k127_3382328_5	485913.Krac_8352	2.284e-110	366.0	COG3568@1|root,COG3568@2|Bacteria	2|Bacteria	N	Endonuclease Exonuclease Phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
HKD2_k127_3382328_1	485913.Krac_8350	1.261e-269	833.0	COG0423@1|root,COG0423@2|Bacteria,2G62M@200795|Chloroflexi	200795|Chloroflexi	J	Belongs to the class-II aminoacyl-tRNA synthetase family	glyQS	GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005488,GO:0005515,GO:0016874,GO:0016875,GO:0046983,GO:0140098,GO:0140101	6.1.1.14	ko:K01880	ko00970,map00970	M00359,M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	HGTP_anticodon,tRNA-synt_2b
HKD2_k127_3389349_1	118168.MC7420_5341	1.464e-38	151.0	COG0265@1|root,COG0265@2|Bacteria,1G3U2@1117|Cyanobacteria,1HCF7@1150|Oscillatoriales	1117|Cyanobacteria	O	Trypsin-like peptidase domain	-	-	-	-	-	-	-	-	-	-	-	-	Trypsin_2
HKD2_k127_3389349_0	485913.Krac_10508	1.08e-208	656.0	COG0018@1|root,COG0018@2|Bacteria,2G6DK@200795|Chloroflexi	200795|Chloroflexi	J	Arginyl-tRNA synthetase	argS	GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
HKD2_k127_3441743_1	485913.Krac_0166	2.714e-25	105.0	COG3335@1|root,COG3335@2|Bacteria	2|Bacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_23,HTH_29,HTH_32
HKD2_k127_3441743_0	1382306.JNIM01000001_gene1118	1.61e-140	452.0	COG0491@1|root,COG0491@2|Bacteria,2G93C@200795|Chloroflexi	200795|Chloroflexi	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HKD2_k127_3441743_2	485913.Krac_2597	3.503e-12	66.0	COG0778@1|root,COG0778@2|Bacteria	2|Bacteria	C	coenzyme F420-1:gamma-L-glutamate ligase activity	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
HKD2_k127_3465128_2	357808.RoseRS_2826	3.201e-81	288.0	COG0596@1|root,COG0596@2|Bacteria,2G6Y2@200795|Chloroflexi	200795|Chloroflexi	I	PFAM alpha beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_4
HKD2_k127_3465128_3	485913.Krac_0256	1.369e-05	49.0	COG3316@1|root,COG3316@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS240
HKD2_k127_3465128_1	1382304.JNIL01000001_gene1690	1.138e-81	279.0	COG1024@1|root,COG1024@2|Bacteria	2|Bacteria	I	Enoyl-CoA hydratase	MA20_43195	-	-	-	-	-	-	-	-	-	-	-	ECH_1
HKD2_k127_3465128_0	485913.Krac_12159	7.553e-174	560.0	COG1716@1|root,COG1716@2|Bacteria	2|Bacteria	T	histone H2A K63-linked ubiquitination	-	-	-	-	-	-	-	-	-	-	-	-	DZR,FHA,zinc_ribbon_2
HKD2_k127_3472162_0	485913.Krac_11143	2.168e-143	466.0	COG1413@1|root,COG1413@2|Bacteria	2|Bacteria	C	deoxyhypusine monooxygenase activity	-	-	3.4.24.3	ko:K01387	-	-	-	-	ko00000,ko01000,ko01002,ko02042	-	-	-	HEAT_2,HEAT_PBS,NACHT,Peptidase_M9,Peptidase_M9_N
HKD2_k127_3472162_1	485913.Krac_11141	8.163e-70	241.0	COG4198@1|root,COG4198@2|Bacteria,2G6FC@200795|Chloroflexi	200795|Chloroflexi	S	Protein of unknown function (DUF1015)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1015
HKD2_k127_3477779_0	485913.Krac_11171	3.213e-189	595.0	COG1071@1|root,COG1071@2|Bacteria,2G6HY@200795|Chloroflexi	200795|Chloroflexi	C	PFAM dehydrogenase, E1 component	-	-	1.2.4.1	ko:K00161,ko:K21416	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
HKD2_k127_3477779_1	485913.Krac_11170	1.289e-183	578.0	COG0022@1|root,COG0022@2|Bacteria,2G5JU@200795|Chloroflexi	200795|Chloroflexi	C	PFAM Transketolase central region	-	-	-	-	-	-	-	-	-	-	-	-	Transket_pyr,Transketolase_C
HKD2_k127_3477779_2	485913.Krac_11169	6.164e-90	305.0	COG0508@1|root,COG0508@2|Bacteria,2G5TB@200795|Chloroflexi	200795|Chloroflexi	C	Catalytic domain of components of various dehydrogenase complexes	-	-	2.3.1.61	ko:K00658	ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R02570,R02571,R08549	RC00004,RC02727,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
HKD2_k127_3485125_0	485913.Krac_11947	4.997e-206	655.0	COG0542@1|root,COG0542@2|Bacteria,2G5RA@200795|Chloroflexi	200795|Chloroflexi	O	ATPase AAA-2 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	AAA,AAA_2,CHAT,ClpB_D2-small,Clp_N
HKD2_k127_3486303_1	1169144.KB910979_gene1570	7.865e-05	48.0	COG3335@1|root,COG3335@2|Bacteria	2|Bacteria	L	DDE superfamily endonuclease	-	-	-	ko:K07494,ko:K07499	-	-	-	-	ko00000	-	-	-	DDE_3,HTH_23,HTH_29,HTH_32,HTH_33
HKD2_k127_3486303_0	485913.Krac_4208	1.186e-101	344.0	COG1612@1|root,COG1612@2|Bacteria,2G75U@200795|Chloroflexi	200795|Chloroflexi	O	PFAM Cytochrome oxidase assembly	-	-	2.5.1.141	ko:K02257,ko:K02259	ko00190,ko00860,ko01100,ko01110,ko02020,ko04714,map00190,map00860,map01100,map01110,map02020,map04714	M00154	R07411,R07412	RC00769,RC01786	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029	3.D.4.4	-	-	COX15-CtaA
HKD2_k127_3490725_0	485913.Krac_11965	4.164e-231	745.0	COG4995@1|root,COG4995@2|Bacteria,2G6X4@200795|Chloroflexi	200795|Chloroflexi	S	PFAM TPR repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CHAT,TPR_12
HKD2_k127_34973_1	1382306.JNIM01000001_gene4105	4.196e-97	319.0	COG1670@1|root,COG1670@2|Bacteria,2G73Y@200795|Chloroflexi	200795|Chloroflexi	J	PFAM GCN5-related N-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
HKD2_k127_34973_0	485913.Krac_12345	8.153e-203	635.0	COG2348@1|root,COG2348@2|Bacteria,2G6KK@200795|Chloroflexi	200795|Chloroflexi	V	PFAM Methicillin resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	FemAB
HKD2_k127_3501084_1	485913.Krac_8032	6.093e-57	205.0	COG2041@1|root,COG2041@2|Bacteria,2G76Y@200795|Chloroflexi	200795|Chloroflexi	S	PFAM oxidoreductase, molybdopterin binding	-	-	-	-	-	-	-	-	-	-	-	-	Mo-co_dimer,Oxidored_molyb
HKD2_k127_3501084_0	485913.Krac_8033	1.045e-126	422.0	COG1216@1|root,COG1216@2|Bacteria	2|Bacteria	V	Glycosyl transferase, family 2	wgeF	-	-	-	-	-	-	-	-	-	-	-	GT87,Glycos_transf_2
HKD2_k127_3505681_2	485913.Krac_3643	2.323e-79	268.0	COG3508@1|root,COG3508@2|Bacteria,2G7RN@200795|Chloroflexi	200795|Chloroflexi	C	PFAM homogentisate 12-dioxygenase	-	-	1.13.11.5	ko:K00451	ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120	M00044	R02519	RC00737	ko00000,ko00001,ko00002,ko01000	-	-	-	HgmA
HKD2_k127_3505681_1	485913.Krac_3644	1.614e-140	451.0	COG0179@1|root,COG0179@2|Bacteria,2G7MW@200795|Chloroflexi	200795|Chloroflexi	Q	PFAM fumarylacetoacetate (FAA) hydrolase	-	-	3.7.1.2	ko:K16171	ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120	M00044	R01364	RC00326,RC00446	ko00000,ko00001,ko00002,ko01000	-	-	-	FAA_hydrolase
HKD2_k127_3505681_0	485913.Krac_3645	7.997e-196	614.0	COG3185@1|root,COG3185@2|Bacteria,2G7XQ@200795|Chloroflexi	200795|Chloroflexi	C	PFAM Glyoxalase bleomycin resistance protein dioxygenase	-	-	1.13.11.27	ko:K00457	ko00130,ko00350,ko00360,ko01100,map00130,map00350,map00360,map01100	M00044	R01372,R02521	RC00505,RC00738	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Glyoxalase
HKD2_k127_3524371_0	485913.Krac_3264	2.891e-80	273.0	COG3361@1|root,COG3361@2|Bacteria	2|Bacteria	S	conserved protein (COG2071)	yqjF	-	-	ko:K09166	-	-	-	-	ko00000	-	-	-	DUF2071
HKD2_k127_3531494_0	1382306.JNIM01000001_gene1062	2.207e-147	477.0	COG0343@1|root,COG0343@2|Bacteria,2G87H@200795|Chloroflexi	200795|Chloroflexi	J	TIGRFAM tRNA-guanine transglycosylase, various specificities	-	-	2.4.2.29	ko:K00773	-	-	R03789,R10209	RC00063	ko00000,ko01000,ko03016	-	-	-	TGT
HKD2_k127_3531494_1	82654.Pse7367_1031	7.197e-80	274.0	2EU2Z@1|root,33MJU@2|Bacteria	2|Bacteria	H	Ribosomal RNA methyltransferase (FmrO)	-	-	2.1.1.179	ko:K18845	-	-	-	-	br01600,ko00000,ko01000,ko01504,ko03009	-	-	-	FmrO
HKD2_k127_3531494_2	485913.Krac_8474	6.991e-59	209.0	COG0477@1|root,COG2814@2|Bacteria,2G8SG@200795|Chloroflexi	200795|Chloroflexi	EGP	PFAM major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD2_k127_3539164_0	448385.sce2119	5.194e-152	487.0	COG4948@1|root,COG4948@2|Bacteria,1MYZE@1224|Proteobacteria,42MY9@68525|delta/epsilon subdivisions,2WKS9@28221|Deltaproteobacteria,2YUFM@29|Myxococcales	28221|Deltaproteobacteria	M	Belongs to the mandelate racemase muconate lactonizing enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	MR_MLE_C,MR_MLE_N
HKD2_k127_3539164_1	1267535.KB906767_gene4036	3.438e-98	331.0	2DMBY@1|root,32ICA@2|Bacteria,3Y65R@57723|Acidobacteria,2JKZE@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3563471_0	1382306.JNIM01000001_gene321	4.484e-119	389.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	ko:K04786	ko01053,map01053	-	-	-	ko00000,ko00001,ko01004,ko01008	-	-	-	Methyltransf_11,Methyltransf_12,Methyltransf_23,Methyltransf_25,Methyltransf_31
HKD2_k127_3581042_3	485913.Krac_12461	7.927e-70	243.0	COG2355@1|root,COG2355@2|Bacteria,2G6FQ@200795|Chloroflexi	200795|Chloroflexi	E	Membrane dipeptidase (Peptidase family M19)	-	-	3.4.13.19	ko:K01273	-	-	-	-	ko00000,ko00537,ko01000,ko01002,ko04147	-	-	-	Peptidase_M19
HKD2_k127_3581042_5	485913.Krac_12460	1.284e-47	174.0	COG0023@1|root,COG0023@2|Bacteria,2G9JW@200795|Chloroflexi	200795|Chloroflexi	J	Translation initiation factor SUI1	-	-	-	ko:K03113	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	SUI1
HKD2_k127_3581042_2	485913.Krac_12457	1.658e-81	278.0	COG2178@1|root,COG2178@2|Bacteria,2G6RW@200795|Chloroflexi	200795|Chloroflexi	J	PFAM Translin	-	-	-	ko:K07477	-	-	-	-	ko00000	-	-	-	-
HKD2_k127_3581042_1	1382306.JNIM01000001_gene3446	1.985e-111	373.0	COG1575@1|root,COG1575@2|Bacteria,2G5ZC@200795|Chloroflexi	200795|Chloroflexi	H	Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK)	menA	-	2.5.1.74	ko:K02548	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R05617,R06858,R10757	RC02935,RC02936,RC03264	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
HKD2_k127_3581042_0	485913.Krac_12386	1.905e-197	629.0	COG2041@1|root,COG2041@2|Bacteria,2G76Y@200795|Chloroflexi	200795|Chloroflexi	S	PFAM oxidoreductase, molybdopterin binding	-	-	-	-	-	-	-	-	-	-	-	-	Mo-co_dimer,Oxidored_molyb
HKD2_k127_3581042_8	485913.Krac_12354	2.844e-12	67.0	COG2146@1|root,COG2146@2|Bacteria	2|Bacteria	P	nitrite reductase [NAD(P)H] activity	-	-	-	-	-	-	-	-	-	-	-	-	Rieske
HKD2_k127_3581042_9	485913.Krac_12354	0.000601	43.0	COG2146@1|root,COG2146@2|Bacteria	2|Bacteria	P	nitrite reductase [NAD(P)H] activity	-	-	-	-	-	-	-	-	-	-	-	-	Rieske
HKD2_k127_3582645_0	485913.Krac_8861	1.144e-189	598.0	COG1804@1|root,COG1804@2|Bacteria,2G7MX@200795|Chloroflexi	200795|Chloroflexi	C	PFAM L-carnitine dehydratase bile acid-inducible protein F	-	-	5.1.99.4	ko:K01796	ko00120,ko01100,ko04146,map00120,map01100,map04146	M00104	R08734,R08739	RC02345	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_transf_3
HKD2_k127_3582645_1	485913.Krac_9130	1.749e-47	176.0	COG0738@1|root,COG0738@2|Bacteria,2G70U@200795|Chloroflexi	200795|Chloroflexi	G	PFAM major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD2_k127_3612669_1	545693.BMQ_3519	4.124e-27	123.0	COG3619@1|root,COG3619@2|Bacteria,1VBZN@1239|Firmicutes,4HMQK@91061|Bacilli,1ZFAA@1386|Bacillus	91061|Bacilli	S	Membrane	yoaK	-	-	-	-	-	-	-	-	-	-	-	DUF1275
HKD2_k127_3612669_0	485913.Krac_11859	4.386e-195	616.0	COG0520@1|root,COG0520@2|Bacteria,2G5W7@200795|Chloroflexi	200795|Chloroflexi	E	TIGRFAM cysteine desulfurase family protein	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
HKD2_k127_3660918_0	1382306.JNIM01000001_gene3580	1.358e-121	401.0	COG5002@1|root,COG5002@2|Bacteria,2G67W@200795|Chloroflexi	200795|Chloroflexi	T	PFAM ATP-binding region, ATPase domain protein	-	-	2.7.13.3	ko:K07636	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4,sCache_like
HKD2_k127_3660918_1	574087.Acear_1404	3.156e-64	229.0	arCOG10456@1|root,2ZA6T@2|Bacteria,1V06C@1239|Firmicutes,24GWM@186801|Clostridia,3WB51@53433|Halanaerobiales	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3662327_0	42256.RradSPS_3086	6.803e-53	191.0	COG1765@1|root,COG1765@2|Bacteria	2|Bacteria	O	OsmC-like protein	yhfA	-	-	ko:K07397	-	-	-	-	ko00000	-	-	-	OsmC
HKD2_k127_3662327_1	877455.Metbo_0285	2.828e-35	137.0	COG1917@1|root,arCOG03004@2157|Archaea,2XYUR@28890|Euryarchaeota,23P5U@183925|Methanobacteria	183925|Methanobacteria	S	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HKD2_k127_3662327_2	644548.SCNU_20167	7.927e-05	52.0	COG1225@1|root,COG1225@2|Bacteria,2IHZ6@201174|Actinobacteria,4GDX7@85026|Gordoniaceae	201174|Actinobacteria	O	Redoxin	bcp	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
HKD2_k127_3679091_0	1382306.JNIM01000001_gene4111	9.904e-158	502.0	COG0761@1|root,COG0761@2|Bacteria,2G75Z@200795|Chloroflexi	200795|Chloroflexi	IM	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis	ispH	-	1.17.7.4	ko:K03527	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05884,R08210	RC01137,RC01487	ko00000,ko00001,ko00002,ko01000	-	-	-	LYTB
HKD2_k127_3679154_4	485913.Krac_8465	3.511e-81	273.0	COG1922@1|root,COG1922@2|Bacteria,2G6J0@200795|Chloroflexi	200795|Chloroflexi	M	Belongs to the glycosyltransferase 26 family	-	-	2.4.1.187	ko:K05946	ko05111,map05111	-	-	-	ko00000,ko00001,ko01000,ko01003	-	GT26	-	Glyco_tran_WecB
HKD2_k127_3679154_1	1382306.JNIM01000001_gene166	9.348e-158	504.0	COG2870@1|root,COG2870@2|Bacteria,2G6G0@200795|Chloroflexi	200795|Chloroflexi	M	PFAM PfkB domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
HKD2_k127_3679154_5	1382306.JNIM01000001_gene165	5.874e-67	232.0	COG0615@1|root,COG0615@2|Bacteria,2G6NJ@200795|Chloroflexi	200795|Chloroflexi	IM	Cytidyltransferase-related domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CTP_transf_like
HKD2_k127_3679154_0	485913.Krac_2226	2.817e-166	542.0	COG0728@1|root,COG0728@2|Bacteria,2G5PF@200795|Chloroflexi	200795|Chloroflexi	S	Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane	-	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
HKD2_k127_3679154_3	485913.Krac_8462	1.807e-104	347.0	COG2120@1|root,COG2120@2|Bacteria,2G6W3@200795|Chloroflexi	200795|Chloroflexi	S	PFAM LmbE family protein	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
HKD2_k127_3679154_2	485913.Krac_8461	4.245e-108	354.0	COG0704@1|root,COG0704@2|Bacteria,2G6HD@200795|Chloroflexi	200795|Chloroflexi	P	Plays a role in the regulation of phosphate uptake	phoU	-	-	ko:K02039	-	-	-	-	ko00000	-	-	-	PhoU
HKD2_k127_3681627_1	448385.sce3488	2.337e-76	264.0	COG1251@1|root,COG1251@2|Bacteria,1MW58@1224|Proteobacteria,43CV0@68525|delta/epsilon subdivisions,2X82S@28221|Deltaproteobacteria,2Z20Q@29|Myxococcales	1224|Proteobacteria	C	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family	-	-	1.7.1.15	ko:K00362	ko00910,ko01120,map00910,map01120	M00530	R00787	RC00176	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_BFD,NIR_SIR,NIR_SIR_ferr,Pyr_redox_2
HKD2_k127_3681627_0	1382306.JNIM01000001_gene1800	1.42e-281	881.0	COG0243@1|root,COG0243@2|Bacteria,2G60X@200795|Chloroflexi	200795|Chloroflexi	C	Molybdopterin oxidoreductase	-	-	1.20.2.1,1.20.9.1	ko:K08356	-	-	-	-	ko00000,ko01000,ko02000	5.A.3.6	-	-	Molybdopterin,Molydop_binding
HKD2_k127_3700681_0	485913.Krac_10794	0.0	1013.0	COG1217@1|root,COG1217@2|Bacteria,2G5NQ@200795|Chloroflexi	200795|Chloroflexi	T	elongation factor Tu domain 2 protein	typA	-	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2
HKD2_k127_370076_1	485913.Krac_10158	7.351e-90	299.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
HKD2_k127_370076_3	485913.Krac_10154	7.439e-35	138.0	COG3437@1|root,COG3437@2|Bacteria	2|Bacteria	T	response regulator, receiver	-	-	3.1.1.61,3.5.1.44	ko:K03412,ko:K03413,ko:K07814	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	HATPase_c,HD_5,HisKA_3,Pyr_redox_2,Response_reg
HKD2_k127_370076_0	485913.Krac_10153	3.886e-128	412.0	COG0745@1|root,COG0745@2|Bacteria,2G6JP@200795|Chloroflexi	200795|Chloroflexi	K	COGs COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	-	-	-	ko:K07667	ko02020,ko02024,map02020,map02024	M00454	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
HKD2_k127_370076_2	1382306.JNIM01000001_gene1783	1.219e-74	257.0	COG5002@1|root,COG5002@2|Bacteria	2|Bacteria	T	protein histidine kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HATPase_c,HisKA,PAS_4,PAS_8,PAS_9
HKD2_k127_371278_1	221109.22778353	1.254e-19	96.0	COG0318@1|root,COG0318@2|Bacteria,1TPSX@1239|Firmicutes,4HB3V@91061|Bacilli,23JMV@182709|Oceanobacillus	91061|Bacilli	IQ	AMP-binding enzyme	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
HKD2_k127_371278_0	1120973.AQXL01000133_gene1816	1.214e-129	427.0	COG0318@1|root,COG0318@2|Bacteria,1TPSX@1239|Firmicutes,4HACS@91061|Bacilli	91061|Bacilli	IQ	Belongs to the ATP-dependent AMP-binding enzyme family. MenE subfamily	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
HKD2_k127_371278_2	1120934.KB894434_gene4646	2.22e-10	62.0	COG0644@1|root,COG0644@2|Bacteria,2GJDF@201174|Actinobacteria,4EEAC@85010|Pseudonocardiales	201174|Actinobacteria	C	FAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3
HKD2_k127_3715417_2	1382306.JNIM01000001_gene1806	1.2e-35	139.0	COG1371@1|root,COG1371@2|Bacteria,2G7BQ@200795|Chloroflexi	200795|Chloroflexi	S	Archease protein family (MTH1598/TM1083)	-	-	-	-	-	-	-	-	-	-	-	-	Archease
HKD2_k127_3715417_1	1382306.JNIM01000001_gene758	1.6e-43	170.0	COG0697@1|root,COG0697@2|Bacteria,2G8R9@200795|Chloroflexi	200795|Chloroflexi	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HKD2_k127_3715417_0	485913.Krac_10009	1.152e-253	787.0	COG0031@1|root,COG0031@2|Bacteria,2G5JV@200795|Chloroflexi	200795|Chloroflexi	E	Pyridoxal-phosphate dependent enzyme	-	-	-	-	-	-	-	-	-	-	-	-	CBS,PALP
HKD2_k127_3734614_0	1382306.JNIM01000001_gene1786	2.012e-292	911.0	COG1506@1|root,COG1506@2|Bacteria,2G5Q5@200795|Chloroflexi	200795|Chloroflexi	EU	PFAM peptidase S9 prolyl oligopeptidase active site domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
HKD2_k127_3734614_1	485913.Krac_11909	1.105e-96	320.0	COG2274@1|root,COG2274@2|Bacteria,2G84I@200795|Chloroflexi	200795|Chloroflexi	V	peptidase C39 bacteriocin processing	-	-	-	-	-	-	-	-	-	-	-	-	ABC_membrane,ABC_tran,Peptidase_C39
HKD2_k127_3737040_1	485913.Krac_8033	2.928e-17	86.0	COG1216@1|root,COG1216@2|Bacteria	2|Bacteria	V	Glycosyl transferase, family 2	wgeF	-	-	-	-	-	-	-	-	-	-	-	GT87,Glycos_transf_2
HKD2_k127_3737040_0	1382306.JNIM01000001_gene3578	5.9e-117	379.0	COG2141@1|root,COG2141@2|Bacteria,2G6CZ@200795|Chloroflexi	200795|Chloroflexi	C	COGs COG2141 Coenzyme F420-dependent N5 N10-methylene tetrahydromethanopterin reductase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
HKD2_k127_3747403_0	485913.Krac_9138	0.0	1247.0	COG0419@1|root,COG1122@1|root,COG0419@2|Bacteria,COG1122@2|Bacteria	2|Bacteria	P	ATPase activity	-	-	2.7.11.1	ko:K03546,ko:K12132,ko:K16786,ko:K16787,ko:K19171	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02000,ko02048,ko03400	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	AAA_23,ABC_tran,SMC_N
HKD2_k127_3747403_1	485913.Krac_9137	1.252e-53	192.0	COG0420@1|root,COG0420@2|Bacteria	2|Bacteria	L	3'-5' exonuclease activity	-	-	-	ko:K03546,ko:K03547	-	-	-	-	ko00000,ko03400	-	-	-	Metallophos,Metallophos_2
HKD2_k127_3762462_1	1382306.JNIM01000001_gene1943	1.007e-117	385.0	COG2047@1|root,COG2047@2|Bacteria,2G9KI@200795|Chloroflexi	200795|Chloroflexi	S	PAC2 family	-	-	-	ko:K07159	-	-	-	-	ko00000	-	-	-	PAC2
HKD2_k127_3762462_0	485913.Krac_1299	2.007e-207	649.0	COG1042@1|root,COG1042@2|Bacteria,2G5QB@200795|Chloroflexi	200795|Chloroflexi	C	PFAM CoA-binding domain protein	-	-	6.2.1.13	ko:K01905,ko:K09181,ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig
HKD2_k127_3776655_3	485913.Krac_10274	5.876e-47	171.0	COG2120@1|root,COG2120@2|Bacteria,2G6YU@200795|Chloroflexi	200795|Chloroflexi	S	PFAM LmbE family protein	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
HKD2_k127_3776655_0	485913.Krac_10275	2.017e-205	655.0	COG0515@1|root,COG0515@2|Bacteria,2G67H@200795|Chloroflexi	485913.Krac_10275|-	KLT	SMART serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3776655_2	485913.Krac_10276	1.288e-49	183.0	COG0801@1|root,COG0801@2|Bacteria,2G6YT@200795|Chloroflexi	200795|Chloroflexi	H	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	-	2.7.6.3	ko:K00950	ko00790,ko01100,map00790,map01100	M00126,M00841	R03503	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	HPPK
HKD2_k127_3776655_1	485913.Krac_10277	1.513e-55	196.0	COG0799@1|root,COG0799@2|Bacteria,2G77A@200795|Chloroflexi	200795|Chloroflexi	J	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation	rsfS	-	-	ko:K09710	-	-	-	-	ko00000,ko03009	-	-	-	RsfS
HKD2_k127_3786266_0	485913.Krac_11909	3.489e-110	363.0	COG2274@1|root,COG2274@2|Bacteria,2G84I@200795|Chloroflexi	200795|Chloroflexi	V	peptidase C39 bacteriocin processing	-	-	-	-	-	-	-	-	-	-	-	-	ABC_membrane,ABC_tran,Peptidase_C39
HKD2_k127_3811562_0	1382306.JNIM01000001_gene1939	4.88e-91	305.0	COG2084@1|root,COG2084@2|Bacteria,2G8E8@200795|Chloroflexi	200795|Chloroflexi	I	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_11,NAD_binding_2
HKD2_k127_3825788_0	485913.Krac_1322	0.0	1043.0	COG3387@1|root,COG3387@2|Bacteria,2G7S0@200795|Chloroflexi	200795|Chloroflexi	G	COGs COG3387 Glucoamylase and related glycosyl hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_15
HKD2_k127_3829157_2	1382306.JNIM01000001_gene479	1.535e-29	117.0	COG2352@1|root,COG2352@2|Bacteria,2G62H@200795|Chloroflexi	200795|Chloroflexi	C	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle	ppc	-	4.1.1.31	ko:K01595	ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200	M00168,M00170,M00171,M00172,M00173,M00346,M00374	R00345	RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPcase
HKD2_k127_3829157_1	1382306.JNIM01000001_gene479	5.105e-66	228.0	COG2352@1|root,COG2352@2|Bacteria,2G62H@200795|Chloroflexi	200795|Chloroflexi	C	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle	ppc	-	4.1.1.31	ko:K01595	ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200	M00168,M00170,M00171,M00172,M00173,M00346,M00374	R00345	RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPcase
HKD2_k127_3829157_0	485913.Krac_11758	5.766e-72	246.0	COG0137@1|root,COG0137@2|Bacteria,2G7ZK@200795|Chloroflexi	200795|Chloroflexi	E	Arginosuccinate synthase	-	-	-	-	-	-	-	-	-	-	-	-	Arginosuc_synth
HKD2_k127_3850995_2	485913.Krac_10479	8.341e-15	74.0	COG0822@1|root,COG0822@2|Bacteria,2G6WC@200795|Chloroflexi	200795|Chloroflexi	C	NifU-like N terminal domain	-	-	-	ko:K04488	-	-	-	-	ko00000	-	-	-	NifU_N
HKD2_k127_3850995_0	485913.Krac_10478	7.161e-86	289.0	COG1573@1|root,COG1573@2|Bacteria,2G8Q5@200795|Chloroflexi	200795|Chloroflexi	L	Uracil DNA glycosylase superfamily	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
HKD2_k127_3850995_1	485913.Krac_10477	9.357e-67	233.0	COG1853@1|root,COG1853@2|Bacteria,2G6XG@200795|Chloroflexi	200795|Chloroflexi	S	PFAM flavin reductase domain protein, FMN-binding	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
HKD2_k127_3855460_0	1382306.JNIM01000001_gene3944	4.81e-139	449.0	COG1940@1|root,COG1940@2|Bacteria,2G6IH@200795|Chloroflexi	200795|Chloroflexi	GK	PFAM ROK family protein	-	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
HKD2_k127_3855460_1	485913.Krac_8867	3.348e-112	374.0	COG0515@1|root,COG0515@2|Bacteria	485913.Krac_8867|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3855460_2	1121472.AQWN01000002_gene2258	3.027e-29	118.0	COG1694@1|root,COG1694@2|Bacteria,1V701@1239|Firmicutes,24KA0@186801|Clostridia,2621J@186807|Peptococcaceae	186801|Clostridia	S	PFAM MazG nucleotide pyrophosphohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	MazG
HKD2_k127_3857780_1	485913.Krac_12028	1.448e-76	265.0	COG0642@1|root,COG2205@2|Bacteria,2GBNP@200795|Chloroflexi	200795|Chloroflexi	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_4
HKD2_k127_3857780_0	485913.Krac_12029	1.675e-125	404.0	COG0745@1|root,COG0745@2|Bacteria,2G8ZD@200795|Chloroflexi	200795|Chloroflexi	K	Two component transcriptional regulator, winged helix family	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
HKD2_k127_3873096_0	485913.Krac_1324	4.458e-144	466.0	COG0624@1|root,COG0624@2|Bacteria,2G63E@200795|Chloroflexi	200795|Chloroflexi	E	peptidase dimerisation domain protein	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
HKD2_k127_3875344_0	485913.Krac_2997	6.946e-155	501.0	COG0477@1|root,COG2814@2|Bacteria,2G6UA@200795|Chloroflexi	200795|Chloroflexi	EGP	TIGRFAM drug resistance transporter, Bcr CflA subfamily	-	-	-	ko:K07552	-	-	-	-	ko00000,ko02000	2.A.1.2	-	-	MFS_1
HKD2_k127_3875344_1	404589.Anae109_2816	3.664e-71	249.0	COG0697@1|root,COG0697@2|Bacteria,1R03B@1224|Proteobacteria,42S5I@68525|delta/epsilon subdivisions,2WNXS@28221|Deltaproteobacteria	28221|Deltaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HKD2_k127_390382_3	485913.Krac_9203	2.33e-42	155.0	COG0050@1|root,COG0050@2|Bacteria,2G5KI@200795|Chloroflexi	200795|Chloroflexi	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
HKD2_k127_390382_0	485913.Krac_9200	5.262e-189	601.0	COG1921@1|root,COG1921@2|Bacteria,2G5VV@200795|Chloroflexi	200795|Chloroflexi	H	Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis	selA	-	2.9.1.1	ko:K01042	ko00450,ko00970,map00450,map00970	-	R08219	RC01246	ko00000,ko00001,ko01000	-	-	-	Se-cys_synth_N,SelA
HKD2_k127_390382_1	485913.Krac_9020	1.055e-146	472.0	COG1162@1|root,COG1162@2|Bacteria,2G5IS@200795|Chloroflexi	200795|Chloroflexi	S	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit	rsgA	-	3.1.3.100	ko:K06949	ko00730,ko01100,map00730,map01100	-	R00615,R02135	RC00002,RC00017	ko00000,ko00001,ko01000,ko03009	-	-	-	RsgA_GTPase,RsgA_N
HKD2_k127_390382_4	485913.Krac_7740	2.508e-36	144.0	COG3464@1|root,COG3464@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	UPF0236
HKD2_k127_3906209_1	102125.Xen7305DRAFT_00048670	1.598e-13	71.0	COG3335@1|root,COG3335@2|Bacteria	2|Bacteria	L	DDE superfamily endonuclease	-	-	-	ko:K07494	-	-	-	-	ko00000	-	-	-	DDE_3
HKD2_k127_3906209_0	1382306.JNIM01000001_gene3362	1.539e-202	635.0	COG0119@1|root,COG0119@2|Bacteria,2G5V9@200795|Chloroflexi	200795|Chloroflexi	H	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)	-	-	2.3.3.13,2.3.3.14	ko:K01649,ko:K02594	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R00271,R01213	RC00004,RC00067,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like
HKD2_k127_3910471_1	1382306.JNIM01000001_gene2706	6.868e-15	78.0	COG1051@1|root,COG1051@2|Bacteria	2|Bacteria	F	GDP-mannose mannosyl hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
HKD2_k127_3910471_0	1382306.JNIM01000001_gene1517	3.719e-257	806.0	COG0366@1|root,COG3387@1|root,COG0366@2|Bacteria,COG3387@2|Bacteria,2G69A@200795|Chloroflexi	200795|Chloroflexi	G	glycoside hydrolase 15-related	-	-	3.2.1.3	ko:K01178	ko00500,ko01100,map00500,map01100	-	R01790,R01791,R06199	-	ko00000,ko00001,ko01000	-	GH15	-	Glucodextran_N,Glyco_hydro_15
HKD2_k127_3924430_1	1382306.JNIM01000001_gene697	9.013e-168	545.0	COG2339@1|root,COG2339@2|Bacteria,2G77M@200795|Chloroflexi	200795|Chloroflexi	S	Protease prsW family	-	-	-	-	-	-	-	-	-	-	-	-	PrsW-protease
HKD2_k127_3924430_0	485913.Krac_11173	3.903e-176	567.0	COG0617@1|root,COG0617@2|Bacteria,2G6B7@200795|Chloroflexi	200795|Chloroflexi	J	PFAM Polynucleotide adenylyltransferase region	-	-	2.7.7.19,2.7.7.72	ko:K00970,ko:K00974	ko03013,ko03018,map03013,map03018	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	HD,PolyA_pol,PolyA_pol_RNAbd,tRNA_NucTran2_2
HKD2_k127_3931093_4	485913.Krac_2347	6.371e-05	46.0	COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,2G8EF@200795|Chloroflexi	2|Bacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_28,HTH_29,HTH_32,HTH_33
HKD2_k127_3931093_2	485913.Krac_10765	1.498e-128	420.0	COG0009@1|root,COG0009@2|Bacteria,2G673@200795|Chloroflexi	200795|Chloroflexi	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine	-	-	2.7.7.87	ko:K07566	-	-	R10463	RC00745	ko00000,ko01000,ko03009,ko03016	-	-	-	SUA5,Sua5_yciO_yrdC
HKD2_k127_3931093_1	485913.Krac_10764	1.809e-220	695.0	COG2508@1|root,COG2508@2|Bacteria,2G6MB@200795|Chloroflexi	200795|Chloroflexi	K	PucR C-terminal helix-turn-helix domain	-	-	-	ko:K09684	-	-	-	-	ko00000,ko03000	-	-	-	HTH_30,PucR
HKD2_k127_3931093_3	485913.Krac_10763	4.414e-99	330.0	COG0457@1|root,COG0457@2|Bacteria,2G6Q2@200795|Chloroflexi	200795|Chloroflexi	S	PFAM TPR repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_2
HKD2_k127_3931093_0	485913.Krac_10762	4.663e-258	803.0	COG0621@1|root,COG0621@2|Bacteria,2G5QK@200795|Chloroflexi	200795|Chloroflexi	J	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine	miaB	-	2.8.4.3	ko:K06168	-	-	R10645,R10646,R10647	RC00003,RC00980,RC03221,RC03222	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
HKD2_k127_3938602_0	1121033.AUCF01000010_gene4546	0.0009137	51.0	2EDX0@1|root,337S1@2|Bacteria,1NJP4@1224|Proteobacteria	1224|Proteobacteria	S	Zinc dependent phospholipase C	-	-	-	-	-	-	-	-	-	-	-	-	Zn_dep_PLPC
HKD2_k127_3939595_0	485913.Krac_10925	1.353e-227	711.0	COG0550@1|root,COG0550@2|Bacteria,2G5ZR@200795|Chloroflexi	200795|Chloroflexi	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,zf-C4_Topoisom
HKD2_k127_3951295_0	1382306.JNIM01000001_gene314	1.93e-202	636.0	COG0183@1|root,COG0183@2|Bacteria,2G5YW@200795|Chloroflexi	200795|Chloroflexi	I	Belongs to the thiolase family	-	-	2.3.1.16	ko:K00632	ko00071,ko00280,ko00281,ko00362,ko00592,ko00642,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00362,map00592,map00642,map01100,map01110,map01120,map01130,map01212	M00087,M00113	R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000	-	-	-	Thiolase_C,Thiolase_N
HKD2_k127_3951295_1	1121106.JQKB01000084_gene6157	1.355e-185	600.0	COG3243@1|root,COG3243@2|Bacteria,1MU68@1224|Proteobacteria,2TR7S@28211|Alphaproteobacteria,2JQCH@204441|Rhodospirillales	28211|Alphaproteobacteria	I	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus	-	-	-	ko:K03821	ko00650,map00650	-	R04254	RC00004	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1,PhaC_N
HKD2_k127_398619_4	1382306.JNIM01000001_gene3907	4.097e-56	201.0	COG0789@1|root,COG0789@2|Bacteria,2G72X@200795|Chloroflexi	200795|Chloroflexi	K	PFAM regulatory protein, MerR	-	-	-	ko:K13640	-	-	-	-	ko00000,ko03000	-	-	-	MerR_1
HKD2_k127_398619_0	1382306.JNIM01000001_gene3905	1.077e-152	489.0	COG0484@1|root,COG0484@2|Bacteria,2G657@200795|Chloroflexi	200795|Chloroflexi	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	-	-	-	ko:K03686,ko:K05516	-	-	-	-	ko00000,ko03029,ko03036,ko03110	-	-	-	DnaJ,DnaJ_C
HKD2_k127_398619_3	485913.Krac_12546	1.442e-64	227.0	COG0576@1|root,COG0576@2|Bacteria	2|Bacteria	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	grpE	GO:0000166,GO:0000774,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0017076,GO:0030234,GO:0030312,GO:0030554,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0036094,GO:0040007,GO:0042594,GO:0044464,GO:0050790,GO:0050896,GO:0051082,GO:0051716,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0071496,GO:0071944,GO:0097159,GO:0098772,GO:1901265,GO:1901363	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
HKD2_k127_398619_1	485913.Krac_12547	1.039e-91	309.0	COG1354@1|root,COG1354@2|Bacteria,2G6WU@200795|Chloroflexi	200795|Chloroflexi	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves	scpA	-	-	ko:K05896	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpA
HKD2_k127_398619_2	485913.Krac_12548	8.332e-65	226.0	COG1418@1|root,COG1418@2|Bacteria	2|Bacteria	S	mRNA catabolic process	rny	-	-	ko:K18682	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	HD
HKD2_k127_398619_5	485913.Krac_12549	2.96e-32	128.0	COG1994@1|root,COG1994@2|Bacteria,2G6VM@200795|Chloroflexi	200795|Chloroflexi	S	Peptidase M50	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M50
HKD2_k127_399271_0	485913.Krac_2717	1.563e-120	407.0	COG3629@1|root,COG3899@1|root,COG3629@2|Bacteria,COG3899@2|Bacteria,2G871@200795|Chloroflexi	200795|Chloroflexi	K	Transcriptional activator domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,BTAD,Trans_reg_C
HKD2_k127_4007847_1	485913.Krac_11083	1.881e-64	224.0	COG0782@1|root,COG0782@2|Bacteria,2G6U9@200795|Chloroflexi	200795|Chloroflexi	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides	greA	-	-	ko:K03624	-	-	-	-	ko00000,ko03021	-	-	-	GreA_GreB,GreA_GreB_N
HKD2_k127_4007847_0	485913.Krac_11084	4.798e-71	244.0	COG1190@1|root,COG1190@2|Bacteria,2G65Z@200795|Chloroflexi	200795|Chloroflexi	J	Belongs to the class-II aminoacyl-tRNA synthetase family	lysS	-	6.1.1.6	ko:K04567	ko00970,map00970	M00359,M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
HKD2_k127_4009995_0	485913.Krac_11310	8.344e-126	407.0	COG1234@1|root,COG1234@2|Bacteria,2G6YW@200795|Chloroflexi	200795|Chloroflexi	S	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA	rnz	-	3.1.26.11	ko:K00784	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Lactamase_B_2
HKD2_k127_4009995_1	485913.Krac_11308	0.0003328	44.0	2APF0@1|root,31EHN@2|Bacteria,2G7DI@200795|Chloroflexi	200795|Chloroflexi	S	Putative zincin peptidase	-	-	-	-	-	-	-	-	-	-	-	-	DUF3267
HKD2_k127_4035551_2	485913.Krac_2492	1.228e-85	321.0	COG0515@1|root,COG0515@2|Bacteria	485913.Krac_2492|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4035551_1	485913.Krac_5820	8.165e-111	399.0	COG5635@1|root,COG5635@2|Bacteria,2G8PW@200795|Chloroflexi	200795|Chloroflexi	T	COGs COG5635 NTPase (NACHT family)	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3,NACHT
HKD2_k127_4035551_0	306281.AJLK01000109_gene3145	1.151e-208	666.0	COG0367@1|root,COG0367@2|Bacteria,1G3S7@1117|Cyanobacteria	1117|Cyanobacteria	E	Asparagine synthase	-	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
HKD2_k127_4035551_4	485913.Krac_3918	3.559e-10	61.0	COG3385@1|root,COG3385@2|Bacteria,2G80K@200795|Chloroflexi	200795|Chloroflexi	L	sptr a7nhu5	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5
HKD2_k127_4035551_5	485913.Krac_10336	2.924e-07	53.0	COG3385@1|root,COG3385@2|Bacteria	2|Bacteria	L	transposase activity	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5,DDE_Tnp_1_4
HKD2_k127_4043107_1	485913.Krac_12134	3.882e-56	200.0	COG0644@1|root,COG0644@2|Bacteria,2G81U@200795|Chloroflexi	200795|Chloroflexi	C	oxidoreductase	-	-	5.5.1.19	ko:K14605	ko00906,ko01100,ko01110,map00906,map01100,map01110	-	R03824,R05341	RC01004	ko00000,ko00001,ko01000	-	-	-	-
HKD2_k127_4043107_0	485913.Krac_12142	2.318e-109	369.0	COG0515@1|root,COG0515@2|Bacteria,2G5NM@200795|Chloroflexi	200795|Chloroflexi	KLT	Serine threonine protein kinase	-	-	2.7.11.1	ko:K08884	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,zinc_ribbon_2
HKD2_k127_4044546_3	485913.Krac_8665	2.162e-48	174.0	COG1278@1|root,COG1278@2|Bacteria,2G79W@200795|Chloroflexi	200795|Chloroflexi	K	Probable zinc-ribbon domain	-	-	-	-	-	-	-	-	-	-	-	-	zf-trcl
HKD2_k127_4044546_0	485913.Krac_8666	4.948e-207	648.0	COG0343@1|root,COG0343@2|Bacteria,2G5RE@200795|Chloroflexi	200795|Chloroflexi	F	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)	tgt	-	2.4.2.29	ko:K00773	-	-	R03789,R10209	RC00063	ko00000,ko01000,ko03016	-	-	-	TGT
HKD2_k127_4044546_1	1382306.JNIM01000001_gene117	2.873e-122	397.0	COG0095@1|root,COG0095@2|Bacteria,2G6P9@200795|Chloroflexi	200795|Chloroflexi	H	PFAM Biotin lipoate A B protein ligase	-	-	6.3.1.20	ko:K03800	ko00785,ko01100,map00785,map01100	-	R07770,R07771,R11143	RC00043,RC00070,RC00090,RC00992,RC02896	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB
HKD2_k127_4044546_2	485913.Krac_8668	8.562e-70	243.0	COG3193@1|root,COG3193@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Haem_degrading
HKD2_k127_4045168_0	1122194.AUHU01000005_gene936	4.351e-10	71.0	COG1716@1|root,COG1716@2|Bacteria,1N8CX@1224|Proteobacteria,1SD00@1236|Gammaproteobacteria,46BTF@72275|Alteromonadaceae	1236|Gammaproteobacteria	T	Forkhead associated domain	-	-	-	-	-	-	-	-	-	-	-	-	FHA
HKD2_k127_4068822_1	485913.Krac_12270	9.877e-209	656.0	COG0612@1|root,COG0612@2|Bacteria,2G672@200795|Chloroflexi	200795|Chloroflexi	S	PFAM peptidase M16 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
HKD2_k127_4068822_0	1382306.JNIM01000001_gene232	2.047e-220	698.0	COG4262@1|root,COG4262@2|Bacteria,2G5YS@200795|Chloroflexi	200795|Chloroflexi	S	Spermine/spermidine synthase domain	-	-	-	-	-	-	-	-	-	-	-	-	Spermine_synth
HKD2_k127_4068822_2	485913.Krac_12272	1.4e-76	267.0	COG0457@1|root,COG0457@2|Bacteria	485913.Krac_12272|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4068992_1	485913.Krac_6699	2.439e-175	559.0	COG0205@1|root,COG0205@2|Bacteria,2G81H@200795|Chloroflexi	200795|Chloroflexi	H	Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions	pfp	-	2.7.1.11,2.7.1.90	ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
HKD2_k127_4068992_0	485913.Krac_6700	7.564e-204	639.0	COG1015@1|root,COG1015@2|Bacteria,2G7S7@200795|Chloroflexi	200795|Chloroflexi	F	Phosphotransfer between the C1 and C5 carbon atoms of pentose	deoB	-	5.4.2.7	ko:K01839	ko00030,ko00230,map00030,map00230	-	R01057,R02749	RC00408	ko00000,ko00001,ko01000	-	-	-	Metalloenzyme
HKD2_k127_4068992_2	485913.Krac_6701	5.754e-43	159.0	COG1670@1|root,COG1670@2|Bacteria	2|Bacteria	J	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
HKD2_k127_4075176_0	1382306.JNIM01000001_gene1783	2.67e-222	710.0	COG5002@1|root,COG5002@2|Bacteria	2|Bacteria	T	protein histidine kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HATPase_c,HisKA,PAS_4,PAS_8,PAS_9
HKD2_k127_4086514_0	485913.Krac_9117	4.046e-126	407.0	COG2986@1|root,COG2986@2|Bacteria,2G66R@200795|Chloroflexi	200795|Chloroflexi	E	PFAM phenylalanine histidine ammonia-lyase	hutH	-	4.3.1.3	ko:K01745	ko00340,ko01100,map00340,map01100	M00045	R01168	RC00361	ko00000,ko00001,ko00002,ko01000	-	-	-	Lyase_aromatic
HKD2_k127_4086514_1	485913.Krac_9122	1.981e-66	229.0	COG1028@1|root,COG1028@2|Bacteria,2G5KB@200795|Chloroflexi	200795|Chloroflexi	IQ	PFAM short-chain dehydrogenase reductase SDR	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HKD2_k127_4114162_0	661478.OP10G_1002	6.83e-280	875.0	COG1251@1|root,COG1251@2|Bacteria	2|Bacteria	C	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family	nasD	-	1.7.1.15	ko:K00362	ko00910,ko01120,map00910,map01120	M00530	R00787	RC00176	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_BFD,NIR_SIR,NIR_SIR_ferr,Pyr_redox_2
HKD2_k127_4114162_2	1382306.JNIM01000001_gene1802	1.957e-32	130.0	COG2146@1|root,COG2146@2|Bacteria	2|Bacteria	P	nitrite reductase [NAD(P)H] activity	nasE	-	1.7.1.15	ko:K00363,ko:K05710	ko00360,ko00910,ko01120,ko01220,map00360,map00910,map01120,map01220	M00530,M00545	R00787,R06782,R06783	RC00098,RC00176	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	Rieske,Rieske_2
HKD2_k127_4114162_1	1382306.JNIM01000001_gene1803	1.818e-68	241.0	COG1587@1|root,COG1587@2|Bacteria,2G8P2@200795|Chloroflexi	200795|Chloroflexi	H	Uroporphyrinogen-III synthase HemD	-	-	4.2.1.75	ko:K01719	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R03165	RC01861	ko00000,ko00001,ko00002,ko01000	-	-	-	HEM4
HKD2_k127_4120944_0	1382306.JNIM01000001_gene1230	4.547e-85	286.0	COG2518@1|root,COG2518@2|Bacteria,2G6NG@200795|Chloroflexi	200795|Chloroflexi	J	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	pcm	-	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
HKD2_k127_4125200_0	1382306.JNIM01000001_gene1820	1.436e-153	501.0	COG0642@1|root,COG2205@2|Bacteria,2G6KS@200795|Chloroflexi	200795|Chloroflexi	T	histidine kinase A domain protein	-	-	2.7.13.3	ko:K07646	ko02020,map02020	M00454	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	DUF4118,GAF,HATPase_c,HisKA
HKD2_k127_4134927_0	485913.Krac_4377	3.73e-102	343.0	COG0457@1|root,COG3903@1|root,COG0457@2|Bacteria,COG3903@2|Bacteria,2G71Q@200795|Chloroflexi	200795|Chloroflexi	NU	TPR repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_31,NB-ARC,TPR_10,TPR_12,TPR_7
HKD2_k127_4134927_1	485913.Krac_4377	7.792e-32	129.0	COG0457@1|root,COG3903@1|root,COG0457@2|Bacteria,COG3903@2|Bacteria,2G71Q@200795|Chloroflexi	200795|Chloroflexi	NU	TPR repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_31,NB-ARC,TPR_10,TPR_12,TPR_7
HKD2_k127_4145383_2	485913.Krac_7300	3.266e-38	149.0	COG4977@1|root,COG4977@2|Bacteria,2G8UD@200795|Chloroflexi	200795|Chloroflexi	K	PFAM helix-turn-helix- domain containing protein AraC type	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18
HKD2_k127_4145383_3	485913.Krac_7797	5.923e-37	144.0	COG0346@1|root,COG0346@2|Bacteria	2|Bacteria	E	lactoylglutathione lyase activity	-	-	-	ko:K05593	-	-	-	-	ko00000,ko01000,ko01504	-	-	-	Adenyl_transf
HKD2_k127_4145383_0	485913.Krac_7798	2.288e-140	452.0	COG0604@1|root,COG0604@2|Bacteria,2G7Z0@200795|Chloroflexi	200795|Chloroflexi	C	PFAM Alcohol dehydrogenase zinc-binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
HKD2_k127_4145383_1	485913.Krac_7799	3.268e-76	258.0	COG1167@1|root,COG1167@2|Bacteria,2G86E@200795|Chloroflexi	200795|Chloroflexi	K	PFAM Aminotransferase class I and II	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
HKD2_k127_4151525_1	1121115.AXVN01000038_gene3331	3.955e-08	58.0	COG1175@1|root,COG1175@2|Bacteria,1TTAF@1239|Firmicutes,24AHK@186801|Clostridia,3XZH7@572511|Blautia	186801|Clostridia	G	Psort location CytoplasmicMembrane, score 10.00	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
HKD2_k127_4151525_0	485913.Krac_0990	2.068e-93	323.0	COG1653@1|root,COG1653@2|Bacteria,2G6WT@200795|Chloroflexi	200795|Chloroflexi	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K10236	ko02010,map02010	M00204	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.17	-	-	SBP_bac_1
HKD2_k127_416596_0	485913.Krac_6791	3.963e-30	123.0	COG2261@1|root,COG2261@2|Bacteria,2G9IB@200795|Chloroflexi	200795|Chloroflexi	S	PFAM Transglycosylase-associated protein	-	-	-	-	-	-	-	-	-	-	-	-	Transgly_assoc
HKD2_k127_416596_1	197221.22295157	4.449e-08	59.0	COG0484@1|root,COG0484@2|Bacteria,1G5UK@1117|Cyanobacteria	1117|Cyanobacteria	O	DnaJ-class molecular chaperone with C-terminal Zn finger domain	-	-	-	-	-	-	-	-	-	-	-	-	DnaJ,TPR_2
HKD2_k127_4167724_2	1382306.JNIM01000001_gene940	1.09e-125	407.0	COG1071@1|root,COG1071@2|Bacteria,2G5SF@200795|Chloroflexi	200795|Chloroflexi	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	pdhA	-	1.2.4.1	ko:K00161	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
HKD2_k127_4167724_0	1382306.JNIM01000001_gene941	4.627e-169	537.0	COG0022@1|root,COG0022@2|Bacteria,2G60F@200795|Chloroflexi	200795|Chloroflexi	C	PFAM Transketolase central region	-	-	1.2.4.1,1.2.4.4	ko:K00162,ko:K11381,ko:K21417	ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00036,M00307	R00014,R00209,R01699,R03270,R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00004,RC00027,RC00627,RC02742,RC02743,RC02744,RC02882,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
HKD2_k127_4167724_1	485913.Krac_8153	5.719e-161	518.0	COG0508@1|root,COG0508@2|Bacteria,2G619@200795|Chloroflexi	200795|Chloroflexi	C	Catalytic domain of components of various dehydrogenase complexes	-	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
HKD2_k127_4167724_3	485913.Krac_11881	2.419e-90	308.0	COG5637@1|root,COG5637@2|Bacteria,2G9EF@200795|Chloroflexi	200795|Chloroflexi	S	PFAM Polyketide cyclase dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc,Polyketide_cyc2
HKD2_k127_4167724_4	1382306.JNIM01000001_gene361	3.538e-46	174.0	COG3568@1|root,COG3568@2|Bacteria	2|Bacteria	N	Endonuclease Exonuclease Phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos,F5_F8_type_C,FIVAR,Glyco_hydro_20,Glyco_hydro_20b,Laminin_G_3,VCBS
HKD2_k127_41753_0	485913.Krac_7191	1.16e-200	637.0	COG2206@1|root,COG2206@2|Bacteria	2|Bacteria	T	PFAM metal-dependent phosphohydrolase, HD sub domain	-	-	-	-	-	-	-	-	-	-	-	-	CHASE6_C,DICT,GerE,HD,HD_5
HKD2_k127_41753_1	1283283.ATXA01000003_gene1561	3.942e-176	564.0	COG1249@1|root,COG1249@2|Bacteria,2IDQR@201174|Actinobacteria,4ETY5@85013|Frankiales	201174|Actinobacteria	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain	-	-	1.8.1.7	ko:K00383	ko00480,ko04918,map00480,map04918	-	R00094,R00115	RC00011	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_dim
HKD2_k127_41753_2	1382306.JNIM01000001_gene3772	9.95e-55	194.0	COG0604@1|root,COG0604@2|Bacteria,2G7Z0@200795|Chloroflexi	200795|Chloroflexi	C	PFAM Alcohol dehydrogenase zinc-binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
HKD2_k127_4196879_3	1382306.JNIM01000001_gene289	7.873e-106	351.0	COG1028@1|root,COG1028@2|Bacteria	1382306.JNIM01000001_gene289|-	IQ	oxidoreductase activity, acting on CH-OH group of donors	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4196879_4	485913.Krac_12260	3.949e-65	224.0	COG0720@1|root,COG0720@2|Bacteria,2G992@200795|Chloroflexi	200795|Chloroflexi	H	PFAM 6-pyruvoyl tetrahydropterin synthase and	-	-	4.1.2.50,4.2.3.12	ko:K01737	ko00790,ko01100,map00790,map01100	M00842,M00843	R04286,R09959	RC01117,RC02846,RC02847	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	PTPS
HKD2_k127_4196879_2	485913.Krac_12261	2.825e-138	448.0	COG0438@1|root,COG0438@2|Bacteria,2G8GB@200795|Chloroflexi	2|Bacteria	M	PFAM glycosyl transferase group 1	-	-	-	ko:K00713,ko:K03867,ko:K06338	-	-	-	-	ko00000,ko01000,ko01003,ko01005	-	GT4	-	Glyco_transf_4,Glycos_transf_1
HKD2_k127_4196879_1	485913.Krac_9018	1.704e-176	561.0	COG2203@1|root,COG4585@1|root,COG2203@2|Bacteria,COG4585@2|Bacteria,2G7TV@200795|Chloroflexi	200795|Chloroflexi	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA_3
HKD2_k127_4196879_5	1382306.JNIM01000001_gene3919	3.606e-50	181.0	COG2197@1|root,COG2197@2|Bacteria,2G6JC@200795|Chloroflexi	200795|Chloroflexi	K	Two component transcriptional regulator, LuxR family	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HKD2_k127_4203736_0	926692.AZYG01000085_gene825	3.245e-182	591.0	COG1501@1|root,COG1501@2|Bacteria,1TR8N@1239|Firmicutes,24A10@186801|Clostridia,3WAHR@53433|Halanaerobiales	186801|Clostridia	G	PFAM Glycosyl hydrolases family 31	-	-	3.2.1.20	ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R06087,R06088	RC00028,RC00049,RC00077	ko00000,ko00001,ko01000	-	GH31	-	DUF4968,DUF5110,Gal_mutarotas_2,Glyco_hydro_31
HKD2_k127_4205039_0	266117.Rxyl_2924	2.498e-155	502.0	COG0531@1|root,COG0531@2|Bacteria,2GJ75@201174|Actinobacteria,4CPDM@84995|Rubrobacteria	84995|Rubrobacteria	E	PFAM amino acid permease-associated region	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
HKD2_k127_4210268_1	1501230.ET33_07075	2.729e-66	237.0	COG4585@1|root,COG5002@1|root,COG4585@2|Bacteria,COG5002@2|Bacteria,1TPDG@1239|Firmicutes,4HUKY@91061|Bacilli,271GY@186822|Paenibacillaceae	91061|Bacilli	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA_3
HKD2_k127_4210268_0	485913.Krac_2537	3.727e-96	319.0	COG2197@1|root,COG2197@2|Bacteria,2G6C5@200795|Chloroflexi	200795|Chloroflexi	K	COGs COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain	-	-	-	ko:K11618	ko02020,map02020	M00481,M00754	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	GerE,Response_reg
HKD2_k127_4210268_2	485913.Krac_1500	6.548e-23	99.0	COG3677@1|root,COG3677@2|Bacteria	2|Bacteria	L	transposition, DNA-mediated	-	-	-	ko:K02529,ko:K20971	ko02025,map02025	-	-	-	ko00000,ko00001,ko01001,ko02022,ko03000	-	-	-	7TMR-DISMED2,7TMR-DISM_7TM,TniQ
HKD2_k127_4247870_0	485913.Krac_12032	9.591e-103	339.0	COG1595@1|root,COG1595@2|Bacteria,2G6T5@200795|Chloroflexi	200795|Chloroflexi	K	PFAM sigma-70 region 2 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD2_k127_426739_2	485913.Krac_12142	9.244e-69	242.0	COG0515@1|root,COG0515@2|Bacteria,2G5NM@200795|Chloroflexi	200795|Chloroflexi	KLT	Serine threonine protein kinase	-	-	2.7.11.1	ko:K08884	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,zinc_ribbon_2
HKD2_k127_426739_0	1382306.JNIM01000001_gene3835	1.85e-201	636.0	COG0213@1|root,COG0213@2|Bacteria,2G64G@200795|Chloroflexi	200795|Chloroflexi	F	PFAM glycosyl transferase family 3	pdp	-	2.4.2.2	ko:K00756	ko00240,ko01100,map00240,map01100	-	R01570,R01876,R02296,R02484	RC00063	ko00000,ko00001,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3,PYNP_C
HKD2_k127_426739_1	485913.Krac_12145	4.693e-144	462.0	COG1158@1|root,COG1158@2|Bacteria,2G5UQ@200795|Chloroflexi	200795|Chloroflexi	K	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template	rho	-	-	ko:K03628	ko03018,map03018	-	-	-	ko00000,ko00001,ko03019,ko03021	-	-	-	ATP-synt_ab,Rho_N,Rho_RNA_bind
HKD2_k127_4272876_1	1382306.JNIM01000001_gene3762	2.412e-27	116.0	COG1287@1|root,COG1287@2|Bacteria,2G75T@200795|Chloroflexi	200795|Chloroflexi	S	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HKD2_k127_4272876_0	1382306.JNIM01000001_gene1311	7.516e-231	729.0	COG1807@1|root,COG1807@2|Bacteria,2GA9D@200795|Chloroflexi	200795|Chloroflexi	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT
HKD2_k127_4274060_3	485913.Krac_1159	1.643e-13	72.0	COG1196@1|root,COG1196@2|Bacteria,2G64A@200795|Chloroflexi	200795|Chloroflexi	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
HKD2_k127_4274060_2	543632.JOJL01000021_gene1016	2.921e-15	81.0	COG2141@1|root,COG2141@2|Bacteria,2GMMJ@201174|Actinobacteria,4DJ6K@85008|Micromonosporales	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
HKD2_k127_4274060_0	485913.Krac_0969	1.981e-100	334.0	COG1011@1|root,COG1011@2|Bacteria,2G9CU@200795|Chloroflexi	200795|Chloroflexi	E	PFAM Haloacid dehalogenase domain protein hydrolase	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2
HKD2_k127_4274060_1	485913.Krac_0971	2.337e-52	188.0	COG0139@1|root,COG0139@2|Bacteria,2G6YA@200795|Chloroflexi	200795|Chloroflexi	E	belongs to the PRA-CH family	hisI	-	3.5.4.19,3.6.1.31	ko:K01496,ko:K11755	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04035,R04037	RC00002,RC01055	ko00000,ko00001,ko00002,ko01000	-	-	-	PRA-CH,PRA-PH
HKD2_k127_4275968_5	485913.Krac_2222	2.951e-32	129.0	COG1186@1|root,COG1186@2|Bacteria	2|Bacteria	J	translation release factor activity	yaeJ	GO:0003674,GO:0003676,GO:0003723,GO:0003747,GO:0003824,GO:0004045,GO:0005488,GO:0006412,GO:0006414,GO:0006415,GO:0006417,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010608,GO:0016043,GO:0016150,GO:0016787,GO:0016788,GO:0019222,GO:0019538,GO:0022411,GO:0031323,GO:0031326,GO:0032268,GO:0032984,GO:0034248,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044877,GO:0050789,GO:0050794,GO:0051171,GO:0051246,GO:0052689,GO:0060255,GO:0065007,GO:0071704,GO:0071840,GO:0072344,GO:0080090,GO:0097159,GO:0140098,GO:0140101,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:2000112	-	ko:K15034	-	-	-	-	ko00000,ko03012	-	-	-	RF-1
HKD2_k127_4275968_7	1166018.FAES_3805	5.1e-07	59.0	2C5JH@1|root,32WG0@2|Bacteria,4P1NG@976|Bacteroidetes,47TH0@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4275968_6	1382306.JNIM01000001_gene1109	1.909e-29	124.0	2F64E@1|root,33YNP@2|Bacteria	2|Bacteria	S	Mycothiol maleylpyruvate isomerase N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2,MDMPI_N
HKD2_k127_4275968_2	485913.Krac_11824	1.551e-97	325.0	COG0007@1|root,COG0007@2|Bacteria	2|Bacteria	H	uroporphyrin-III C-methyltransferase activity	cobA	-	1.3.1.76,2.1.1.107,4.2.1.75,4.99.1.4	ko:K02302,ko:K02303,ko:K13542	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02864,R03165,R03194,R03947	RC00003,RC00871,RC01012,RC01034,RC01861	ko00000,ko00001,ko00002,ko01000	-	-	-	HEM4,TP_methylase
HKD2_k127_4275968_3	485913.Krac_11823	1.027e-73	256.0	COG1648@1|root,COG1648@2|Bacteria,2G753@200795|Chloroflexi	200795|Chloroflexi	H	Sirohaem biosynthesis protein central	-	-	1.3.1.76,4.99.1.4	ko:K02304	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02864,R03947	RC01012,RC01034	ko00000,ko00001,ko00002,ko01000	-	-	-	CysG_dimeriser,NAD_binding_7,Sirohm_synth_M
HKD2_k127_4275968_0	485913.Krac_11822	6.694e-275	856.0	COG0155@1|root,COG0155@2|Bacteria,2G7ZA@200795|Chloroflexi	200795|Chloroflexi	C	Nitrite and sulphite reductase 4Fe-4S domain	-	-	1.8.7.1	ko:K00392	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00176	R00859,R03600	RC00065	ko00000,ko00001,ko00002,ko01000	-	-	-	NIR_SIR,NIR_SIR_ferr
HKD2_k127_4275968_4	479434.Sthe_2979	1.633e-55	203.0	COG2514@1|root,COG2514@2|Bacteria,2G6MQ@200795|Chloroflexi,27YFG@189775|Thermomicrobia	189775|Thermomicrobia	S	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	1.13.11.2	ko:K07104	ko00361,ko00362,ko00622,ko00643,ko01100,ko01120,ko01220,map00361,map00362,map00622,map00643,map01100,map01120,map01220	M00569	R00816,R04089,R05295,R05404,R05406,R07795	RC00387,RC00643,RC01075,RC01364,RC01914	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyoxalase
HKD2_k127_4275968_1	1521187.JPIM01000040_gene530	5.663e-132	433.0	COG1804@1|root,COG1804@2|Bacteria,2G812@200795|Chloroflexi	200795|Chloroflexi	C	PFAM L-carnitine dehydratase bile acid-inducible protein F	-	GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0008410,GO:0015977,GO:0016740,GO:0016782,GO:0043427,GO:0071704	2.8.3.20	ko:K18313	-	-	R10640,R10641	RC00014	ko00000,ko01000	-	-	-	CoA_transf_3
HKD2_k127_4287907_1	485913.Krac_2205	8.768e-58	208.0	2DBDP@1|root,32TXA@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4287907_0	485913.Krac_6839	1.186e-141	455.0	COG1606@1|root,COG1606@2|Bacteria,2G6AU@200795|Chloroflexi	200795|Chloroflexi	L	tRNA processing	-	-	-	ko:K06864	-	-	-	-	ko00000	-	-	-	Asn_synthase,NAD_synthase
HKD2_k127_4287907_2	485913.Krac_6840	3.32e-12	70.0	COG2068@1|root,COG2068@2|Bacteria,2G6W9@200795|Chloroflexi	200795|Chloroflexi	S	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	-	-	2.7.7.76	ko:K07141	ko00790,map00790	-	R11582	-	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
HKD2_k127_4300168_0	1382306.JNIM01000001_gene3891	3.153e-253	793.0	COG0318@1|root,COG0318@2|Bacteria	2|Bacteria	IQ	PFAM AMP-dependent synthetase and ligase	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
HKD2_k127_4319052_0	485913.Krac_8138	1.1e-154	494.0	COG0449@1|root,COG0449@2|Bacteria,2G5V6@200795|Chloroflexi	200795|Chloroflexi	M	PFAM sugar isomerase (SIS)	-	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	SIS
HKD2_k127_4319052_1	1128421.JAGA01000001_gene2281	7.595e-141	457.0	COG1820@1|root,COG1820@2|Bacteria,2NQC1@2323|unclassified Bacteria	2|Bacteria	G	Amidohydrolase family	nagA	-	3.5.1.25	ko:K01443	ko00520,ko01130,map00520,map01130	-	R02059	RC00166,RC00300	ko00000,ko00001,ko01000	-	-	iNJ661.Rv3332	Amidohydro_1
HKD2_k127_4326092_0	485913.Krac_8415	2.516e-182	577.0	COG1600@1|root,COG1600@2|Bacteria,2G6A0@200795|Chloroflexi	200795|Chloroflexi	C	4Fe-4S double cluster binding domain	-	-	1.17.99.6	ko:K18979	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DUF1730,Dehalogenase,Fer4_16,HEAT_2
HKD2_k127_4330114_1	485913.Krac_6711	3.395e-140	448.0	COG2197@1|root,COG2197@2|Bacteria,2G7U4@200795|Chloroflexi	200795|Chloroflexi	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
HKD2_k127_4330114_0	485913.Krac_6710	2.049e-315	983.0	COG4585@1|root,COG4585@2|Bacteria,2G7W5@200795|Chloroflexi	200795|Chloroflexi	T	Histidine kinase-like ATPases	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4331070_1	485913.Krac_8828	4.292e-90	301.0	COG2227@1|root,COG2227@2|Bacteria	2|Bacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	sumf2	-	2.1.1.295	ko:K15257,ko:K18534	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00112	R07501,R10709,R10710	RC00003,RC01662	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	DinB_2,FGE-sulfatase,Methyltransf_11,Methyltransf_23,Methyltransf_25,Methyltransf_31
HKD2_k127_4331070_0	485913.Krac_8830	1.072e-99	328.0	COG0154@1|root,COG0154@2|Bacteria,2G7S4@200795|Chloroflexi	200795|Chloroflexi	J	Belongs to the amidase family	-	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
HKD2_k127_4333713_2	485913.Krac_6822	1.368e-39	149.0	COG1024@1|root,COG1024@2|Bacteria,2G7Z4@200795|Chloroflexi	200795|Chloroflexi	I	PFAM Enoyl-CoA hydratase isomerase	-	-	4.2.1.18	ko:K13766	ko00280,ko01100,map00280,map01100	M00036	R02085	RC02416	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
HKD2_k127_4333713_0	485913.Krac_6823	5.735e-275	860.0	COG4770@1|root,COG4770@2|Bacteria,2GBIE@200795|Chloroflexi	200795|Chloroflexi	I	Carbamoyl-phosphate synthetase large chain domain protein	-	-	6.4.1.4	ko:K01968	ko00280,ko01100,map00280,map01100	M00036	R04138	RC00367,RC00942	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2
HKD2_k127_4333713_1	485913.Krac_6824	2.017e-140	451.0	COG2084@1|root,COG2084@2|Bacteria,2G6B3@200795|Chloroflexi	200795|Chloroflexi	I	6-phosphogluconate dehydrogenase, NAD-binding	-	-	1.1.1.31,1.1.1.60	ko:K00020,ko:K00042	ko00280,ko00630,ko01100,map00280,map00630,map01100	-	R01745,R01747,R05066	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
HKD2_k127_433947_2	1382306.JNIM01000001_gene1259	4.064e-30	122.0	COG2267@1|root,COG2267@2|Bacteria,2G6W2@200795|Chloroflexi	200795|Chloroflexi	I	PFAM alpha beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
HKD2_k127_433947_0	1382306.JNIM01000001_gene1260	3.729e-41	155.0	COG0792@1|root,COG0792@2|Bacteria,2G7AR@200795|Chloroflexi	200795|Chloroflexi	L	Belongs to the UPF0102 family	-	-	-	ko:K07460	-	-	-	-	ko00000	-	-	-	UPF0102
HKD2_k127_433947_1	485913.Krac_10960	1.682e-33	131.0	2DPVJ@1|root,333JK@2|Bacteria,2G9JX@200795|Chloroflexi	200795|Chloroflexi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	zinc_ribbon_2
HKD2_k127_4352019_1	485913.Krac_8520	8.63e-155	496.0	COG1565@1|root,COG1565@2|Bacteria,2G8NS@200795|Chloroflexi	200795|Chloroflexi	S	Putative S-adenosyl-L-methionine-dependent methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_28
HKD2_k127_4352019_2	485913.Krac_2500	2.714e-145	473.0	COG1215@1|root,COG1215@2|Bacteria,2G6RJ@200795|Chloroflexi	200795|Chloroflexi	M	PFAM Glycosyl transferase family 2	-	-	-	ko:K14597	ko00906,map00906	-	R07544,R07546	RC00262	ko00000,ko00001	-	-	-	Glycos_transf_2
HKD2_k127_4352019_0	485913.Krac_8525	3.724e-155	512.0	COG1276@1|root,COG2372@1|root,COG1276@2|Bacteria,COG2372@2|Bacteria	2|Bacteria	C	response to copper ion	-	-	-	ko:K07156,ko:K14166	-	-	-	-	ko00000,ko02000	9.B.62.2	-	-	CopC,CopD,YtkA
HKD2_k127_4352983_1	1382306.JNIM01000001_gene572	8.894e-84	279.0	COG0066@1|root,COG0066@2|Bacteria,2G6PB@200795|Chloroflexi	200795|Chloroflexi	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuD	-	4.2.1.33,4.2.1.35	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R10170	RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase_C
HKD2_k127_4352983_0	485913.Krac_11808	2.985e-161	514.0	COG0473@1|root,COG0473@2|Bacteria,2G66J@200795|Chloroflexi	200795|Chloroflexi	C	PFAM isocitrate isopropylmalate dehydrogenase	-	-	1.1.1.87	ko:K05824	ko00300,ko01100,ko01120,ko01130,ko01210,ko01230,map00300,map01100,map01120,map01130,map01210,map01230	M00030,M00433	R01934,R01936,R04862	RC00084,RC00114,RC00626	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
HKD2_k127_43535_1	485913.Krac_4641	9.272e-21	104.0	COG3595@1|root,COG3595@2|Bacteria,2G9KA@200795|Chloroflexi	200795|Chloroflexi	S	Putative adhesin	-	-	-	-	-	-	-	-	-	-	-	-	DUF4097
HKD2_k127_43535_0	485913.Krac_8606	5.1e-25	108.0	arCOG03922@1|root,33G2Q@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF3054)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3054
HKD2_k127_4355691_2	1382306.JNIM01000001_gene2659	3.478e-72	244.0	COG0714@1|root,COG0714@2|Bacteria,2G5WI@200795|Chloroflexi	200795|Chloroflexi	S	PFAM ATPase associated with various cellular activities, AAA_5	-	-	-	-	-	-	-	-	-	-	-	-	AAA_5
HKD2_k127_4355691_0	485913.Krac_10578	1.592e-217	683.0	COG3552@1|root,COG3552@2|Bacteria,2G5IW@200795|Chloroflexi	200795|Chloroflexi	S	PFAM VWA containing CoxE family protein	-	-	-	ko:K07161	-	-	-	-	ko00000	-	-	-	VWA_CoxE
HKD2_k127_4355691_3	1382306.JNIM01000001_gene2661	2.249e-53	191.0	COG1975@1|root,COG1975@2|Bacteria,2G6Z8@200795|Chloroflexi	200795|Chloroflexi	O	XdhC and CoxI family	-	-	-	-	-	-	-	-	-	-	-	-	XdhC_CoxI
HKD2_k127_4355691_1	1382306.JNIM01000001_gene2662	4.476e-110	361.0	COG1975@1|root,COG1975@2|Bacteria,2G6H0@200795|Chloroflexi	200795|Chloroflexi	O	XdhC Rossmann domain	-	-	-	ko:K07402	-	-	-	-	ko00000	-	-	-	XdhC_C,XdhC_CoxI
HKD2_k127_4355691_4	1382306.JNIM01000001_gene2663	2.116e-14	78.0	COG1316@1|root,COG1316@2|Bacteria	2|Bacteria	K	TRANSCRIPTIONal	-	-	-	-	-	-	-	-	-	-	-	-	LytR_cpsA_psr
HKD2_k127_4375151_0	1254432.SCE1572_36820	8.542e-51	188.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,42M8F@68525|delta/epsilon subdivisions,2WIU0@28221|Deltaproteobacteria,2YXKV@29|Myxococcales	28221|Deltaproteobacteria	P	Cation transporter/ATPase, N-terminus	-	-	3.6.3.2	ko:K01531,ko:K12955	-	-	-	-	ko00000,ko01000	3.A.3.24,3.A.3.4	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
HKD2_k127_4377169_0	485913.Krac_12478	2.426e-242	753.0	COG0439@1|root,COG0439@2|Bacteria,2G62X@200795|Chloroflexi	200795|Chloroflexi	I	Carbamoyl-phosphate synthetase large chain domain protein	accC	-	6.3.4.14,6.4.1.2,6.4.1.3,6.4.1.4	ko:K01961,ko:K01968,ko:K11263	ko00061,ko00280,ko00620,ko00630,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00280,map00620,map00630,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00036,M00082,M00376,M00741	R00742,R01859,R04138,R04385	RC00040,RC00097,RC00253,RC00367,RC00609,RC00942	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2
HKD2_k127_4377169_1	1382306.JNIM01000001_gene3504	1.189e-100	335.0	COG0566@1|root,COG0566@2|Bacteria,2G6MC@200795|Chloroflexi	200795|Chloroflexi	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family	-	-	-	ko:K03437	-	-	-	-	ko00000,ko03016	-	-	-	SpoU_methylase,SpoU_sub_bind
HKD2_k127_4378299_4	1220589.CD32_04385	2.826e-30	122.0	COG0042@1|root,COG0042@2|Bacteria,1TQ2R@1239|Firmicutes,4HA9K@91061|Bacilli,3IW7S@400634|Lysinibacillus	91061|Bacilli	J	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines	dus	-	-	-	-	-	-	-	-	-	-	-	Dus
HKD2_k127_4378299_0	485913.Krac_7836	2.227e-224	699.0	COG1960@1|root,COG1960@2|Bacteria,2G7JH@200795|Chloroflexi	200795|Chloroflexi	C	PFAM acyl-CoA dehydrogenase domain protein	-	-	1.3.8.6	ko:K00252	ko00071,ko00310,ko00362,ko00380,ko01100,ko01120,ko01130,map00071,map00310,map00362,map00380,map01100,map01120,map01130	M00032	R02487,R02488,R10074	RC00052,RC00156	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HKD2_k127_4378299_1	1382306.JNIM01000001_gene2708	7.219e-90	302.0	COG0586@1|root,COG0586@2|Bacteria,2G79V@200795|Chloroflexi	200795|Chloroflexi	S	SNARE associated Golgi protein	-	-	-	ko:K03975	-	-	-	-	ko00000	-	-	-	SNARE_assoc
HKD2_k127_4378299_3	1382306.JNIM01000001_gene892	4.969e-33	136.0	COG0489@1|root,COG0489@2|Bacteria	2|Bacteria	D	protein tyrosine kinase activity	epsG	-	2.7.10.1	ko:K08252	-	-	-	-	ko00000,ko01000	-	-	-	AAA_31,CbiA,ParA
HKD2_k127_4378299_5	485913.Krac_7831	0.0004981	44.0	COG3944@1|root,COG3944@2|Bacteria	2|Bacteria	M	capsule polysaccharide biosynthetic process	-	-	-	ko:K16692	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	GNVR,Wzz
HKD2_k127_4383311_2	471857.Svir_11000	2.256e-08	58.0	COG0748@1|root,COG0748@2|Bacteria,2I3CW@201174|Actinobacteria	201174|Actinobacteria	P	F420H(2)-dependent quinone reductase	-	-	-	-	-	-	-	-	-	-	-	-	F420H2_quin_red
HKD2_k127_4383311_1	1479238.JQMZ01000001_gene1051	2.762e-10	61.0	COG0288@1|root,COG0288@2|Bacteria,1R3SC@1224|Proteobacteria,2U3D4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Reversible hydration of carbon dioxide	-	-	4.2.1.1	ko:K01673	ko00910,map00910	-	R00132,R10092	RC02807	ko00000,ko00001,ko01000	-	-	-	Pro_CA
HKD2_k127_4383311_3	1382306.JNIM01000001_gene4057	8.954e-06	52.0	29XJW@1|root,30JAY@2|Bacteria,2G9IH@200795|Chloroflexi	200795|Chloroflexi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4383311_0	485913.Krac_10267	2.174e-176	562.0	COG0153@1|root,COG0153@2|Bacteria,2G6CE@200795|Chloroflexi	200795|Chloroflexi	F	Belongs to the GHMP kinase family. GalK subfamily	galK	-	2.7.1.6	ko:K00849	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00554,M00632	R01092	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	GHMP_kinases_C,GHMP_kinases_N,GalKase_gal_bdg
HKD2_k127_4391766_0	485913.Krac_8259	1.605e-158	507.0	COG1233@1|root,COG1233@2|Bacteria,2G68M@200795|Chloroflexi	200795|Chloroflexi	Q	PFAM amine oxidase	-	-	1.3.99.26,1.3.99.28,1.3.99.29,1.3.99.31	ko:K10027	ko00906,ko01100,ko01110,map00906,map01100,map01110	-	R04787,R04798,R04800,R09691,R09692	RC01214,RC02088,RC02605	ko00000,ko00001,ko01000	-	-	-	Amino_oxidase
HKD2_k127_4406964_1	485913.Krac_9139	1.562e-137	443.0	COG0324@1|root,COG0324@2|Bacteria,2G5S7@200795|Chloroflexi	200795|Chloroflexi	J	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)	miaA	GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016765,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0052381,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.5.1.75	ko:K00791	ko00908,ko01100,ko01110,map00908,map01100,map01110	-	R01122	RC02820	ko00000,ko00001,ko01000,ko01006,ko03016	-	-	-	IPPT
HKD2_k127_4406964_0	1382306.JNIM01000001_gene4128	7.199e-153	506.0	COG0515@1|root,COG0515@2|Bacteria,2G850@200795|Chloroflexi	200795|Chloroflexi	KLT	Serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
HKD2_k127_4414846_0	485913.Krac_12166	4.471e-287	895.0	COG0308@1|root,COG1413@1|root,COG0308@2|Bacteria,COG1413@2|Bacteria,2G75V@200795|Chloroflexi	200795|Chloroflexi	E	PFAM peptidase M1, membrane alanine aminopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,Peptidase_M1
HKD2_k127_4435326_1	485913.Krac_8950	1.329e-26	117.0	COG0392@1|root,COG0392@2|Bacteria,2G9G7@200795|Chloroflexi	200795|Chloroflexi	S	Lysylphosphatidylglycerol synthase TM region	-	-	-	ko:K07027	-	-	-	-	ko00000,ko02000	4.D.2	-	-	LPG_synthase_TM
HKD2_k127_4435326_0	1382306.JNIM01000001_gene434	1.269e-120	396.0	COG0451@1|root,COG0451@2|Bacteria,2G6S4@200795|Chloroflexi	200795|Chloroflexi	M	Short-chain dehydrogenase reductase SDR	-	-	5.1.3.6	ko:K08679	ko00520,ko01100,map00520,map01100	-	R01385	RC00289	ko00000,ko00001,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
HKD2_k127_44522_1	485913.Krac_8970	5.852e-65	228.0	COG2317@1|root,COG2317@2|Bacteria,2G7UQ@200795|Chloroflexi	200795|Chloroflexi	E	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues	-	-	3.4.17.19	ko:K01299	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M32
HKD2_k127_44522_0	1382306.JNIM01000001_gene2506	7.362e-69	247.0	COG1597@1|root,COG1597@2|Bacteria	2|Bacteria	I	lipid kinase activity	bmrU	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	DAGK_cat,PAP2
HKD2_k127_44522_2	1128421.JAGA01000003_gene2753	3.873e-08	55.0	COG0474@1|root,COG0474@2|Bacteria,2NNSC@2323|unclassified Bacteria	2|Bacteria	P	Cation transporter/ATPase, N-terminus	pacL2	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
HKD2_k127_4457384_0	1382306.JNIM01000001_gene618	2.55e-119	387.0	COG0174@1|root,COG0174@2|Bacteria,2G7P0@200795|Chloroflexi	200795|Chloroflexi	E	Glutamine synthetase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Gln-synt_C
HKD2_k127_4457384_1	485913.Krac_2575	2.477e-112	369.0	COG1502@1|root,COG1502@2|Bacteria	2|Bacteria	I	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol	-	-	3.1.4.4	ko:K01115	ko00564,ko00565,ko01100,ko01110,ko04014,ko04024,ko04071,ko04072,ko04144,ko04666,ko04724,ko04912,ko05231,map00564,map00565,map01100,map01110,map04014,map04024,map04071,map04072,map04144,map04666,map04724,map04912,map05231	-	R01310,R02051,R07385	RC00017,RC00425	ko00000,ko00001,ko01000,ko04131	-	-	-	PLDc,PLDc_2
HKD2_k127_447500_1	485913.Krac_7969	3.875e-250	781.0	COG4992@1|root,COG4992@2|Bacteria	2|Bacteria	E	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity	patA	-	2.6.1.11,2.6.1.17,2.6.1.82	ko:K00821,ko:K05830,ko:K09251	ko00220,ko00300,ko00330,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map00330,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00031,M00763,M00845	R01155,R02283,R04475,R09778,R10932	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
HKD2_k127_447500_2	395961.Cyan7425_1835	4.856e-83	289.0	COG1748@1|root,COG1748@2|Bacteria,1G37A@1117|Cyanobacteria	1117|Cyanobacteria	E	Saccharopine dehydrogenase C-terminal domain	-	-	1.5.1.7	ko:K00290	ko00300,ko00310,ko01100,ko01110,ko01130,ko01230,map00300,map00310,map01100,map01110,map01130,map01230	M00030,M00032	R00715	RC00217,RC01532	ko00000,ko00001,ko00002,ko01000	-	-	-	Sacchrp_dh_C,Sacchrp_dh_NADP
HKD2_k127_447500_0	485913.Krac_2942	2.592e-277	857.0	COG1012@1|root,COG1012@2|Bacteria,2G5JE@200795|Chloroflexi	200795|Chloroflexi	C	Belongs to the aldehyde dehydrogenase family	-	-	1.2.1.8	ko:K00130	ko00260,ko01100,map00260,map01100	M00555	R02565,R02566	RC00080	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
HKD2_k127_4482059_2	103733.JNYO01000002_gene474	5.198e-14	73.0	COG3288@1|root,COG3288@2|Bacteria,2IKR9@201174|Actinobacteria,4E5KZ@85010|Pseudonocardiales	201174|Actinobacteria	C	4TM region of pyridine nucleotide transhydrogenase, mitoch	pntAB	-	1.6.1.2	ko:K00324	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	PNTB_4TM
HKD2_k127_4482059_0	351607.Acel_2020	1.045e-146	478.0	COG1282@1|root,COG1282@2|Bacteria,2GNKB@201174|Actinobacteria,4ERWF@85013|Frankiales	201174|Actinobacteria	C	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane	pntB	-	1.6.1.2	ko:K00325	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	PNTB
HKD2_k127_448991_0	485913.Krac_0981	5.584e-59	207.0	COG0391@1|root,COG0391@2|Bacteria,2G5S2@200795|Chloroflexi	200795|Chloroflexi	S	TIGRFAM LPPG domain protein containing protein	cofD	-	2.7.8.28	ko:K11212	ko00680,ko01120,map00680,map01120	M00378	R09398	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	UPF0052
HKD2_k127_448991_1	485913.Krac_0982	8.189e-56	202.0	COG1920@1|root,COG1920@2|Bacteria,2G76R@200795|Chloroflexi	200795|Chloroflexi	H	Guanylyltransferase that catalyzes the activation of 2- phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor	cofC	GO:0003674,GO:0003824,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0043814,GO:0044237,GO:0044249,GO:0051186,GO:0051188,GO:0070568	2.7.7.68	ko:K14941	ko00680,ko01120,map00680,map01120	M00378	R09397	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CofC
HKD2_k127_4490208_1	485913.Krac_2793	4.61e-113	373.0	COG0619@1|root,COG0619@2|Bacteria	2|Bacteria	P	transmembrane transporter activity	-	-	-	ko:K16783,ko:K16785	ko02010,map02010	M00581,M00582	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.25,3.A.1.25.1,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	CbiQ
HKD2_k127_4490208_0	485913.Krac_2792	2.129e-265	828.0	COG1123@1|root,COG4172@2|Bacteria,2GBJ7@200795|Chloroflexi	2|Bacteria	P	COGs COG1123 ATPase components of various ABC-type transport systems contain duplicated ATPase	-	-	3.6.3.24	ko:K02031,ko:K02032,ko:K10824,ko:K15587,ko:K16784,ko:K16786,ko:K16787	ko02010,ko02024,map02010,map02024	M00239,M00440,M00581,M00582	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.25,3.A.1.25.1,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35,3.A.1.5	-	-	ABC_tran
HKD2_k127_4490208_2	485913.Krac_2683	1.002e-97	325.0	COG3447@1|root,COG3447@2|Bacteria	2|Bacteria	T	MASE1 domain protein	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	HATPase_c
HKD2_k127_4490208_3	485913.Krac_2681	1.982e-60	214.0	COG0402@1|root,COG0402@2|Bacteria,2G6DG@200795|Chloroflexi	2|Bacteria	F	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine	-	-	3.5.4.3	ko:K01487	ko00230,ko01100,map00230,map01100	-	R01676	RC00204	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
HKD2_k127_4492212_0	485913.Krac_0473	3.704e-145	470.0	COG0514@1|root,COG0514@2|Bacteria,2G6S8@200795|Chloroflexi	200795|Chloroflexi	L	ATP-dependent DNA helicase RecQ	-	-	3.6.4.12	ko:K03654	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,HRDC,HTH_40,Helicase_C,RQC,RecQ_Zn_bind
HKD2_k127_4493054_0	485913.Krac_2115	2.282e-139	451.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
HKD2_k127_4493054_1	485913.Krac_11878	1.412e-61	224.0	COG0642@1|root,COG2205@2|Bacteria	485913.Krac_11878|-	T	PhoQ Sensor	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4493054_2	485913.Krac_11000	4.628e-52	185.0	COG1609@1|root,COG1609@2|Bacteria	2|Bacteria	K	purine nucleotide biosynthetic process	-	-	5.3.1.12	ko:K01812,ko:K02529,ko:K16210	ko00040,ko01100,map00040,map01100	M00061,M00631	R01482,R01983	RC00376	ko00000,ko00001,ko00002,ko01000,ko02000,ko03000	2.A.2.5	-	-	DDE_Tnp_ISAZ013,Peripla_BP_3
HKD2_k127_4505144_3	485913.Krac_11110	2.085e-91	306.0	COG0192@1|root,COG0192@2|Bacteria,2G5X0@200795|Chloroflexi	200795|Chloroflexi	H	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme	metK	GO:0003674,GO:0003824,GO:0004478,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016740,GO:0016765,GO:0044424,GO:0044444,GO:0044464	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
HKD2_k127_4505144_0	485913.Krac_11112	1.792e-234	729.0	COG0499@1|root,COG0499@2|Bacteria,2G5X8@200795|Chloroflexi	200795|Chloroflexi	H	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine	ahcY	-	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
HKD2_k127_4505144_1	485913.Krac_11113	2.857e-144	463.0	COG0524@1|root,COG0524@2|Bacteria	2|Bacteria	G	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway	adoK	GO:0000166,GO:0000287,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0004001,GO:0005488,GO:0005524,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0005975,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019200,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032549,GO:0032550,GO:0032552,GO:0032553,GO:0032554,GO:0032555,GO:0032559,GO:0032560,GO:0032561,GO:0032567,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046390,GO:0046483,GO:0046835,GO:0046872,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.7.1.15,2.7.1.20	ko:K00852,ko:K00856	ko00030,ko00230,ko01100,map00030,map00230,map01100	-	R00185,R01051,R02750	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	iAF987.Gmet_2683	PfkB
HKD2_k127_4505144_4	1382306.JNIM01000001_gene1166	4.105e-83	280.0	COG1418@1|root,COG1418@2|Bacteria,2G9HV@200795|Chloroflexi	200795|Chloroflexi	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	ko:K06950	-	-	-	-	ko00000	-	-	-	HD
HKD2_k127_4505144_2	1382306.JNIM01000001_gene1165	4.519e-124	404.0	COG0182@1|root,COG0182@2|Bacteria,2G5Z3@200795|Chloroflexi	200795|Chloroflexi	J	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)	mtnA	-	5.3.1.23	ko:K08963	ko00270,ko01100,map00270,map01100	M00034	R04420	RC01151	ko00000,ko00001,ko00002,ko01000	-	-	-	IF-2B
HKD2_k127_4506948_1	485913.Krac_6768	2.134e-62	218.0	COG2030@1|root,COG2030@2|Bacteria,2G91F@200795|Chloroflexi	200795|Chloroflexi	I	N-terminal half of MaoC dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydrat_N
HKD2_k127_4506948_0	1382306.JNIM01000001_gene3888	6.879e-75	254.0	COG2030@1|root,COG2030@2|Bacteria	2|Bacteria	I	dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydrat_N,MaoC_dehydratas
HKD2_k127_4522489_0	1382306.JNIM01000001_gene1384	7.612e-171	539.0	COG0443@1|root,COG0443@2|Bacteria,2G5U5@200795|Chloroflexi	200795|Chloroflexi	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
HKD2_k127_4522489_1	1220534.B655_1305	2.543e-66	235.0	COG0596@1|root,arCOG01648@2157|Archaea,2XVXV@28890|Euryarchaeota,23PSC@183925|Methanobacteria	183925|Methanobacteria	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
HKD2_k127_4526484_2	485913.Krac_10784	2.381e-31	124.0	COG0159@1|root,COG0159@2|Bacteria,2G6AY@200795|Chloroflexi	200795|Chloroflexi	E	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate	trpA	-	4.2.1.20	ko:K01695	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_syntA
HKD2_k127_4526484_1	1382306.JNIM01000001_gene2653	4.86e-48	174.0	COG4401@1|root,COG4401@2|Bacteria,2G6VB@200795|Chloroflexi	200795|Chloroflexi	E	PFAM Chorismate mutase of the AroH class	-	-	5.4.99.5	ko:K06208	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024,M00025	R01715	RC03116	ko00000,ko00001,ko00002,ko01000	-	-	-	CM_1
HKD2_k127_4526484_0	485913.Krac_10786	1.845e-177	561.0	COG2876@1|root,COG2876@2|Bacteria,2G643@200795|Chloroflexi	200795|Chloroflexi	E	PFAM DAHP synthetase I KDSA	-	-	2.5.1.54	ko:K03856	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_1
HKD2_k127_4526484_3	485913.Krac_10788	1.616e-19	89.0	COG0720@1|root,COG0720@2|Bacteria,2G919@200795|Chloroflexi	200795|Chloroflexi	H	6-pyruvoyl tetrahydropterin synthase	-	-	4.1.2.50,4.2.3.12	ko:K01737	ko00790,ko01100,map00790,map01100	M00842,M00843	R04286,R09959	RC01117,RC02846,RC02847	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	PTPS
HKD2_k127_4535717_0	485913.Krac_12535	0.0	1251.0	COG0085@1|root,COG0085@2|Bacteria,2G5VH@200795|Chloroflexi	200795|Chloroflexi	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
HKD2_k127_4554875_0	485913.Krac_12591	3.153e-222	696.0	COG0617@1|root,COG0617@2|Bacteria,2G6B7@200795|Chloroflexi	200795|Chloroflexi	J	PFAM Polynucleotide adenylyltransferase region	-	-	2.7.7.19,2.7.7.72	ko:K00970,ko:K00974	ko03013,ko03018,map03013,map03018	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	HD,PolyA_pol,PolyA_pol_RNAbd
HKD2_k127_4561898_2	234267.Acid_5417	4.837e-24	112.0	COG0726@1|root,COG0726@2|Bacteria,3Y5MF@57723|Acidobacteria	57723|Acidobacteria	G	PFAM Polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
HKD2_k127_4562456_1	485913.Krac_10877	1.815e-151	494.0	COG1472@1|root,COG1472@2|Bacteria,2G8JU@200795|Chloroflexi	200795|Chloroflexi	G	PFAM glycoside hydrolase, family 3 domain protein	-	-	3.2.1.52	ko:K01207	ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501	M00628	R00022,R05963,R07809,R07810,R10831	RC00049	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyco_hydro_3
HKD2_k127_4562456_0	485913.Krac_10875	0.0	1540.0	COG1413@1|root,COG5635@1|root,COG1413@2|Bacteria,COG5635@2|Bacteria	2|Bacteria	T	Nacht domain	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,NACHT,NB-ARC,cNMP_binding
HKD2_k127_4570581_0	485913.Krac_9055	3.008e-188	601.0	COG1007@1|root,COG1007@2|Bacteria,2G5ZK@200795|Chloroflexi	200795|Chloroflexi	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoN	-	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
HKD2_k127_457687_0	485913.Krac_12422	7.115e-244	765.0	COG0466@1|root,COG0466@2|Bacteria,2G5TZ@200795|Chloroflexi	200795|Chloroflexi	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
HKD2_k127_457687_1	1382306.JNIM01000001_gene3449	1.755e-59	209.0	COG0071@1|root,COG0071@2|Bacteria,2G7BB@200795|Chloroflexi	200795|Chloroflexi	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	-	-	-	-	-	-	-	-	-	HSP20
HKD2_k127_4580177_0	102129.Lepto7375DRAFT_7860	4.748e-10	72.0	COG0457@1|root,COG0457@2|Bacteria,1G135@1117|Cyanobacteria	1117|Cyanobacteria	U	tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_12
HKD2_k127_4580177_1	388051.AUFE01000046_gene2497	0.0001029	55.0	COG3899@1|root,COG3903@1|root,COG3899@2|Bacteria,COG3903@2|Bacteria,1MUDT@1224|Proteobacteria,2VPH8@28216|Betaproteobacteria,1KCSE@119060|Burkholderiaceae	28216|Betaproteobacteria	K	Bacterial transcriptional activator domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,BTAD
HKD2_k127_4586491_1	479434.Sthe_0045	1.801e-40	152.0	COG0859@1|root,COG0859@2|Bacteria,2GA3U@200795|Chloroflexi,27Z33@189775|Thermomicrobia	189775|Thermomicrobia	M	Glycosyltransferase family 9 (heptosyltransferase)	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_9
HKD2_k127_4586491_0	1382356.JQMP01000001_gene1070	8.521e-111	362.0	COG0438@1|root,COG0438@2|Bacteria,2GBD2@200795|Chloroflexi,27YUE@189775|Thermomicrobia	189775|Thermomicrobia	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4593360_0	485913.Krac_10515	1.278e-207	649.0	COG0458@1|root,COG0458@2|Bacteria,2G5NX@200795|Chloroflexi	200795|Chloroflexi	F	Carbamoyl-phosphate synthetase large chain domain protein	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
HKD2_k127_4593360_1	485913.Krac_10516	4.442e-175	555.0	COG0505@1|root,COG0505@2|Bacteria,2G5S1@200795|Chloroflexi	200795|Chloroflexi	F	Belongs to the CarA family	carA	-	6.3.5.5	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_sm_chain,GATase
HKD2_k127_4593360_2	485913.Krac_10517	4.765e-137	443.0	COG0540@1|root,COG0540@2|Bacteria,2G6GU@200795|Chloroflexi	200795|Chloroflexi	F	Belongs to the ATCase OTCase family	pyrB	GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
HKD2_k127_4601088_1	485913.Krac_10187	4.891e-74	261.0	COG0619@1|root,COG0619@2|Bacteria	2|Bacteria	P	transmembrane transporter activity	-	-	-	ko:K16785,ko:K16786,ko:K16787	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	ABC_tran,CbiQ
HKD2_k127_4601088_0	485913.Krac_10188	5.57e-84	284.0	COG1122@1|root,COG1122@2|Bacteria,2G5RY@200795|Chloroflexi	2|Bacteria	P	PFAM ABC transporter related	ecfA	-	-	ko:K16784,ko:K16787	ko02010,map02010	M00581,M00582	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.25,3.A.1.25.1,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	ABC_tran
HKD2_k127_4638604_4	485913.Krac_10955	4.689e-25	107.0	COG1940@1|root,COG1940@2|Bacteria,2G6I0@200795|Chloroflexi	200795|Chloroflexi	GK	PFAM ROK family protein	-	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
HKD2_k127_4638604_0	485913.Krac_10956	1.157e-181	575.0	COG0533@1|root,COG0533@2|Bacteria,2G5V0@200795|Chloroflexi	200795|Chloroflexi	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction	tsaD	GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0019538,GO:0043170,GO:0044238,GO:0071704,GO:1901564	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
HKD2_k127_4638604_1	485913.Krac_10957	4.799e-101	332.0	COG0454@1|root,COG0456@2|Bacteria,2G6TF@200795|Chloroflexi	200795|Chloroflexi	K	Ribosomal-protein-alanine acetyltransferase	rimI	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1
HKD2_k127_4638604_2	485913.Krac_10958	8.11e-83	283.0	COG1214@1|root,COG1214@2|Bacteria,2G6VT@200795|Chloroflexi	200795|Chloroflexi	O	PFAM peptidase M22 glycoprotease	-	-	-	ko:K14742	-	-	-	-	ko00000,ko03016	-	-	-	Peptidase_M22
HKD2_k127_4638604_3	243164.DET0396	3.344e-38	150.0	COG0802@1|root,COG0802@2|Bacteria,2G6YV@200795|Chloroflexi,34CZN@301297|Dehalococcoidia	301297|Dehalococcoidia	S	Threonylcarbamoyl adenosine biosynthesis protein TsaE	-	-	-	ko:K06925	-	-	-	-	ko00000,ko03016	-	-	-	TsaE
HKD2_k127_4638604_5	118168.MC7420_996	5.321e-11	68.0	COG0732@1|root,COG0732@2|Bacteria,1G1K5@1117|Cyanobacteria,1HAGE@1150|Oscillatoriales	1117|Cyanobacteria	V	type I restriction modification DNA specificity domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
HKD2_k127_4668890_0	485913.Krac_8663	0.0	1058.0	COG0317@1|root,COG0317@2|Bacteria,2G67Y@200795|Chloroflexi	200795|Chloroflexi	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	relA	-	2.7.6.5	ko:K00951	ko00230,map00230	-	R00429	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
HKD2_k127_4671893_0	485913.Krac_8189	2.499e-142	462.0	COG2848@1|root,COG2848@2|Bacteria,2G6HQ@200795|Chloroflexi	200795|Chloroflexi	S	Uncharacterised ACR (DUF711)	-	-	-	ko:K09157	-	-	-	-	ko00000	-	-	-	DUF711
HKD2_k127_4671979_0	1382306.JNIM01000001_gene2449	3.472e-99	331.0	COG2265@1|root,COG2265@2|Bacteria,2G95U@200795|Chloroflexi	200795|Chloroflexi	J	DREV methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4671979_1	485913.Krac_6951	7.971e-65	225.0	COG3427@1|root,COG3427@2|Bacteria	2|Bacteria	E	oxidoreductase activity, acting on CH-OH group of donors	-	-	-	ko:K09386	-	-	-	-	ko00000	-	-	-	COXG
HKD2_k127_4678004_3	1382306.JNIM01000001_gene2855	1.487e-45	169.0	COG1912@1|root,COG1912@2|Bacteria,2G6NI@200795|Chloroflexi	200795|Chloroflexi	S	S-adenosyl-l-methionine hydroxide adenosyltransferase	-	-	-	ko:K22205	-	-	-	-	ko00000,ko01000	-	-	-	SAM_adeno_trans
HKD2_k127_4678004_0	485913.Krac_8175	0.0	1155.0	COG2766@1|root,COG2766@2|Bacteria,2G65T@200795|Chloroflexi	200795|Chloroflexi	T	PrkA AAA domain protein	-	-	-	ko:K07180	-	-	-	-	ko00000	-	-	-	AAA_PrkA,PrkA
HKD2_k127_4678004_2	485913.Krac_8174	3.912e-228	709.0	COG2718@1|root,COG2718@2|Bacteria,2G6DB@200795|Chloroflexi	200795|Chloroflexi	S	Belongs to the UPF0229 family	-	-	-	ko:K09786	-	-	-	-	ko00000	-	-	-	DUF444
HKD2_k127_4678004_1	1382306.JNIM01000001_gene2851	2.49e-258	803.0	COG2719@1|root,COG2719@2|Bacteria,2G5PX@200795|Chloroflexi	200795|Chloroflexi	S	SpoVR like protein	-	-	-	ko:K06415	-	-	-	-	ko00000	-	-	-	SpoVR
HKD2_k127_4684572_0	485913.Krac_7977	1.902e-166	541.0	COG0728@1|root,COG0728@2|Bacteria,2G87R@200795|Chloroflexi	200795|Chloroflexi	S	virulence factor MVIN family protein	-	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
HKD2_k127_4684572_4	485913.Krac_7979	1.365e-26	111.0	COG3729@1|root,COG3729@2|Bacteria	2|Bacteria	D	General stress protein	-	-	-	ko:K06884	-	-	-	-	ko00000	-	-	-	KGG
HKD2_k127_4684572_3	485913.Krac_7980	1.003e-36	142.0	COG0745@1|root,COG0745@2|Bacteria	485913.Krac_7980|-	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4684572_2	1382306.JNIM01000001_gene1123	4.012e-60	224.0	COG5002@1|root,COG5002@2|Bacteria	2|Bacteria	T	protein histidine kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA
HKD2_k127_4686951_2	485913.Krac_12006	1.301e-06	51.0	COG2271@1|root,COG2271@2|Bacteria	2|Bacteria	G	transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD2_k127_4686951_0	485913.Krac_12007	2.305e-109	361.0	COG1381@1|root,COG1381@2|Bacteria,2G6N7@200795|Chloroflexi	200795|Chloroflexi	L	Involved in DNA repair and RecF pathway recombination	recO	-	-	ko:K03584	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecO_C,RecO_N
HKD2_k127_4690754_0	485913.Krac_9793	2.358e-46	177.0	COG0642@1|root,COG2205@2|Bacteria,2G6KS@200795|Chloroflexi	200795|Chloroflexi	T	histidine kinase A domain protein	-	-	2.7.13.3	ko:K07646	ko02020,map02020	M00454	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	DUF4118,GAF,HATPase_c,HisKA
HKD2_k127_4694432_0	485913.Krac_8190	7.701e-295	921.0	COG1112@1|root,COG1112@2|Bacteria,2G6PW@200795|Chloroflexi	200795|Chloroflexi	L	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_11,AAA_12,Dna2
HKD2_k127_4696836_1	1499967.BAYZ01000170_gene5494	1.901e-48	178.0	COG2154@1|root,COG2154@2|Bacteria	2|Bacteria	H	pterin-4-alpha-carbinolamine dehydratase	phhB	GO:0003674,GO:0003824,GO:0006066,GO:0006725,GO:0006729,GO:0006732,GO:0006807,GO:0008124,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0017144,GO:0018130,GO:0019438,GO:0019751,GO:0034311,GO:0034312,GO:0034641,GO:0042558,GO:0042559,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	4.2.1.96	ko:K01724	ko00790,map00790	-	R04734	RC01208	ko00000,ko00001,ko01000,ko04147	-	-	-	Pterin_4a
HKD2_k127_4696836_0	383372.Rcas_1338	2.013e-93	317.0	COG0665@1|root,COG0665@2|Bacteria,2G7VQ@200795|Chloroflexi,375TB@32061|Chloroflexia	32061|Chloroflexia	E	PFAM FAD dependent oxidoreductase	-	-	-	ko:K09471	ko00330,ko01100,map00330,map01100	M00136	R07415	RC00062	ko00000,ko00001,ko00002,ko01000	-	-	-	DAO
HKD2_k127_4699891_0	1499967.BAYZ01000176_gene5652	1.149e-89	302.0	COG0451@1|root,COG0451@2|Bacteria,2NNT0@2323|unclassified Bacteria	2|Bacteria	M	Polysaccharide biosynthesis protein	ytcB	-	5.1.3.2,5.1.3.6	ko:K01784,ko:K08679	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R01385,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
HKD2_k127_4706884_1	485913.Krac_1433	5.665e-28	113.0	COG3316@1|root,COG3316@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K18320	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS240
HKD2_k127_4706884_0	756067.MicvaDRAFT_2507	0.0	1151.0	COG1020@1|root,COG1020@2|Bacteria,1G0XE@1117|Cyanobacteria,1H837@1150|Oscillatoriales	1117|Cyanobacteria	Q	Non-ribosomal peptide synthetase modules and related	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,Formyl_trans_N,Methyltransf_12,PP-binding,PilZ
HKD2_k127_4708030_0	485913.Krac_8966	1.018e-79	284.0	COG0515@1|root,COG0515@2|Bacteria,2G7ZS@200795|Chloroflexi	485913.Krac_8966|-	KLT	Serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4708256_0	1382306.JNIM01000001_gene2581	1.162e-296	922.0	COG0646@1|root,COG0685@1|root,COG0646@2|Bacteria,COG0685@2|Bacteria,2G674@200795|Chloroflexi	200795|Chloroflexi	H	Homocysteine S-methyltransferase	-	-	1.5.1.20,2.1.1.10	ko:K00297,ko:K00547	ko00270,ko00670,ko00720,ko01100,ko01110,ko01120,ko01200,ko01523,map00270,map00670,map00720,map01100,map01110,map01120,map01200,map01523	M00377	R00650,R01224,R07168	RC00003,RC00035,RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	MTHFR,S-methyl_trans
HKD2_k127_4708742_0	485913.Krac_12335	8.324e-105	365.0	COG1316@1|root,COG1316@2|Bacteria,2G6PZ@200795|Chloroflexi	200795|Chloroflexi	K	TIGRFAM cell envelope-related function transcriptional attenuator, LytR CpsA family	-	-	-	-	-	-	-	-	-	-	-	-	LytR_C,LytR_cpsA_psr
HKD2_k127_4708742_1	1382306.JNIM01000001_gene3930	9.701e-74	254.0	COG2110@1|root,COG2110@2|Bacteria,2G7ID@200795|Chloroflexi	200795|Chloroflexi	F	PFAM Appr-1-p processing domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Macro
HKD2_k127_4713139_1	485913.Krac_5130	2.724e-100	334.0	COG1073@1|root,COG1073@2|Bacteria	2|Bacteria	S	thiolester hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
HKD2_k127_4713139_0	1123288.SOV_2c06740	5.753e-119	400.0	COG0297@1|root,COG0297@2|Bacteria,1TQ4M@1239|Firmicutes,4H2FF@909932|Negativicutes	909932|Negativicutes	G	Synthesizes alpha-1,4-glucan chains using ADP-glucose	glgA	-	2.4.1.21	ko:K00703	ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026	M00565	R02421	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT5	-	Glyco_transf_5,Glycos_transf_1
HKD2_k127_4713139_2	1382356.JQMP01000004_gene276	2.652e-69	241.0	COG0448@1|root,COG0448@2|Bacteria,2G66Q@200795|Chloroflexi,27XFC@189775|Thermomicrobia	189775|Thermomicrobia	H	Nucleotidyl transferase	glgC	-	2.7.7.27	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	M00565	R00948	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase
HKD2_k127_474786_1	485913.Krac_8857	2.117e-41	154.0	COG1522@1|root,COG1522@2|Bacteria,2G99D@200795|Chloroflexi	200795|Chloroflexi	K	PFAM regulatory protein AsnC Lrp family	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg
HKD2_k127_474786_0	485913.Krac_8856	1.665e-67	234.0	COG1670@1|root,COG1670@2|Bacteria	2|Bacteria	J	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins	p20	-	2.3.1.128	ko:K03790	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_3
HKD2_k127_4756638_4	485913.Krac_7766	6.41e-13	69.0	COG1722@1|root,COG1722@2|Bacteria	2|Bacteria	L	exodeoxyribonuclease VII activity	xseB	GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008855,GO:0009056,GO:0009057,GO:0009318,GO:0009987,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0019439,GO:0032991,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901361,GO:1901575,GO:1902494	3.1.11.6	ko:K03602	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_S
HKD2_k127_4756638_0	485913.Krac_7767	4.595e-166	530.0	COG1570@1|root,COG1570@2|Bacteria,2G5M3@200795|Chloroflexi	200795|Chloroflexi	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseA	-	3.1.11.6	ko:K03601	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_L,tRNA_anti_2
HKD2_k127_4756638_3	485913.Krac_7768	8.712e-52	188.0	COG0511@1|root,COG0511@2|Bacteria,2G94M@200795|Chloroflexi	200795|Chloroflexi	I	first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA	-	-	-	ko:K02160	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742	RC00040,RC00367	ko00000,ko00001,ko00002	-	-	-	Biotin_lipoyl
HKD2_k127_4756638_2	1382306.JNIM01000001_gene1345	7.427e-95	313.0	COG0231@1|root,COG0231@2|Bacteria,2G6PY@200795|Chloroflexi	200795|Chloroflexi	J	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase	efp	-	-	ko:K02356	-	-	-	-	ko00000,ko03012	-	-	-	EFP,EFP_N,Elong-fact-P_C
HKD2_k127_4756638_1	1382306.JNIM01000001_gene1344	1.326e-121	395.0	COG0006@1|root,COG0006@2|Bacteria,2G6AE@200795|Chloroflexi	200795|Chloroflexi	E	Belongs to the peptidase M24B family	-	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Peptidase_M24
HKD2_k127_4760246_1	479431.Namu_5063	1.075e-123	422.0	COG0421@1|root,COG0421@2|Bacteria	2|Bacteria	E	spermidine synthase activity	-	-	-	-	-	-	-	-	-	-	-	-	Spermine_synth
HKD2_k127_4760246_0	485913.Krac_0397	4.464e-142	468.0	29BBV@1|root,2ZCHD@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	NAGPA
HKD2_k127_4770451_1	485913.Krac_6951	4.153e-17	81.0	COG3427@1|root,COG3427@2|Bacteria	2|Bacteria	E	oxidoreductase activity, acting on CH-OH group of donors	-	-	-	ko:K09386	-	-	-	-	ko00000	-	-	-	COXG
HKD2_k127_4770451_0	485913.Krac_1321	2e-182	578.0	COG1092@1|root,COG1092@2|Bacteria,2G5YR@200795|Chloroflexi	200795|Chloroflexi	J	SMART PUA domain containing protein	-	-	2.1.1.191	ko:K06969	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_SAM
HKD2_k127_4786747_2	485913.Krac_9440	1.132e-39	148.0	COG1961@1|root,COG1961@2|Bacteria,2G981@200795|Chloroflexi	200795|Chloroflexi	L	Resolvase, N terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_7,Resolvase
HKD2_k127_4786747_1	1172179.AUKV01000003_gene7403	8.833e-44	163.0	COG3324@1|root,COG3324@2|Bacteria,2IKX6@201174|Actinobacteria	201174|Actinobacteria	S	DinB family	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HKD2_k127_4786747_4	65497.JODV01000019_gene1738	0.0002263	45.0	COG0596@1|root,COG0596@2|Bacteria,2IDI0@201174|Actinobacteria,4E7KI@85010|Pseudonocardiales	201174|Actinobacteria	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
HKD2_k127_4786747_0	316274.Haur_2562	9.01e-58	208.0	COG1280@1|root,COG1280@2|Bacteria,2G9QD@200795|Chloroflexi,377BI@32061|Chloroflexia	32061|Chloroflexia	E	PFAM Lysine exporter protein (LYSE YGGA)	-	-	-	-	-	-	-	-	-	-	-	-	LysE
HKD2_k127_4789743_0	485913.Krac_8935	4.3e-105	347.0	COG2071@1|root,COG2071@2|Bacteria,2G6QN@200795|Chloroflexi	200795|Chloroflexi	S	PFAM glutamine amidotransferase class-I	-	-	-	ko:K07010	-	-	-	-	ko00000,ko01002	-	-	-	Peptidase_C26
HKD2_k127_4803693_2	1382306.JNIM01000001_gene3021	7.45e-12	66.0	COG1457@1|root,COG1457@2|Bacteria	2|Bacteria	F	cytosine transport	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4803693_0	485913.Krac_12578	5.187e-298	938.0	COG0642@1|root,COG2205@2|Bacteria	485913.Krac_12578|-	T	PhoQ Sensor	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4803693_1	485913.Krac_12372	2.999e-97	322.0	COG1473@1|root,COG1473@2|Bacteria,2G5WT@200795|Chloroflexi	200795|Chloroflexi	S	Peptidase dimerisation domain protein	-	-	-	ko:K01436	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20
HKD2_k127_4804195_3	485913.Krac_1302	4.029e-64	224.0	COG0265@1|root,COG0265@2|Bacteria,2G8HP@200795|Chloroflexi	200795|Chloroflexi	O	Trypsin	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
HKD2_k127_4804195_4	485913.Krac_9834	5.234e-42	159.0	COG0745@1|root,COG0745@2|Bacteria,2G9RK@200795|Chloroflexi	200795|Chloroflexi	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
HKD2_k127_4804195_1	485913.Krac_11806	1.408e-98	333.0	COG0491@1|root,COG0491@2|Bacteria	2|Bacteria	GM	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HKD2_k127_4804195_0	1382306.JNIM01000001_gene1912	3.068e-127	415.0	COG1055@1|root,COG1055@2|Bacteria,2G69P@200795|Chloroflexi	200795|Chloroflexi	P	Arsenical pump membrane protein	-	-	-	ko:K03893	-	-	-	-	ko00000,ko02000	2.A.45.1,3.A.4.1	-	-	ArsB
HKD2_k127_4826876_0	1121438.JNJA01000001_gene2540	1.305e-99	337.0	COG0463@1|root,COG0463@2|Bacteria,1MWE5@1224|Proteobacteria,42MCE@68525|delta/epsilon subdivisions,2WIYP@28221|Deltaproteobacteria,2MGAZ@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	PFAM Glycosyl transferase family 2	-	-	2.4.2.53	ko:K10012	ko00520,ko01503,map00520,map01503	M00721,M00761	R07661	RC00005,RC02954	ko00000,ko00001,ko00002,ko01000,ko01005,ko02000	4.D.2.1.8	GT2	-	Glycos_transf_2
HKD2_k127_4833075_0	485913.Krac_11258	0.0	1537.0	COG0249@1|root,COG0249@2|Bacteria,2G5IU@200795|Chloroflexi	200795|Chloroflexi	L	that it carries out the mismatch recognition step. This protein has a weak ATPase activity	mutS	-	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
HKD2_k127_4833075_2	1123248.KB893314_gene3297	2.124e-07	53.0	COG0021@1|root,COG0021@2|Bacteria,4P14U@976|Bacteroidetes,1INZ8@117747|Sphingobacteriia	976|Bacteroidetes	G	Belongs to the transketolase family	tkt	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
HKD2_k127_4833075_1	485913.Krac_11261	2.884e-182	576.0	COG0176@1|root,COG0176@2|Bacteria,2GA93@200795|Chloroflexi	200795|Chloroflexi	H	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway	-	-	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
HKD2_k127_4834929_5	485913.Krac_3943	1.908e-15	78.0	COG3316@1|root,COG3316@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K18320	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS240
HKD2_k127_4834929_4	485913.Krac_6976	4.104e-44	163.0	COG0675@1|root,COG0675@2|Bacteria,2G89V@200795|Chloroflexi	200795|Chloroflexi	L	TIGRFAM transposase, IS605 OrfB family	-	-	-	ko:K07496	-	-	-	-	ko00000	-	-	-	HTH_OrfB_IS605,OrfB_IS605,OrfB_Zn_ribbon
HKD2_k127_4834929_0	1382306.JNIM01000001_gene752	2.457e-153	498.0	COG5002@1|root,COG5002@2|Bacteria,2G6F5@200795|Chloroflexi	200795|Chloroflexi	T	PFAM ATP-binding region, ATPase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
HKD2_k127_4834929_1	1382306.JNIM01000001_gene751	2.847e-123	398.0	COG0745@1|root,COG0745@2|Bacteria,2G6H6@200795|Chloroflexi	200795|Chloroflexi	K	Two component transcriptional regulator, winged helix family	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
HKD2_k127_4834929_3	1382306.JNIM01000001_gene3063	1.259e-74	259.0	COG4097@1|root,COG4097@2|Bacteria,2G71Y@200795|Chloroflexi	200795|Chloroflexi	P	Ferric reductase like transmembrane component	-	-	-	-	-	-	-	-	-	-	-	-	Ferric_reduct
HKD2_k127_4834929_2	485913.Krac_3055	8.648e-119	393.0	COG1477@1|root,COG1477@2|Bacteria,2G6WH@200795|Chloroflexi	200795|Chloroflexi	H	Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein	-	-	2.7.1.180	ko:K03734	-	-	-	-	ko00000,ko01000	-	-	-	ApbE
HKD2_k127_4835113_0	1382306.JNIM01000001_gene3677	5.783e-179	565.0	COG2141@1|root,COG2141@2|Bacteria,2G727@200795|Chloroflexi	200795|Chloroflexi	C	Luciferase-like monooxygenase	-	-	1.5.98.2	ko:K00320	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R04464	RC01607	ko00000,ko00001,ko00002,ko01000	-	-	-	Bac_luciferase
HKD2_k127_4835113_1	485913.Krac_12210	2.2e-151	489.0	COG0025@1|root,COG0025@2|Bacteria,2G6RR@200795|Chloroflexi	200795|Chloroflexi	P	Sodium/hydrogen exchanger family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
HKD2_k127_4842462_1	1382306.JNIM01000001_gene3514	1.775e-179	578.0	COG4166@1|root,COG4166@2|Bacteria,2G7WT@200795|Chloroflexi	200795|Chloroflexi	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_5
HKD2_k127_4842462_0	485913.Krac_12489	9.465e-211	672.0	COG0608@1|root,COG0608@2|Bacteria,2G5US@200795|Chloroflexi	200795|Chloroflexi	L	PFAM phosphoesterase, RecJ domain protein	recJ	-	-	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
HKD2_k127_4842462_2	485913.Krac_12488	2.878e-94	311.0	COG0635@1|root,COG0635@2|Bacteria,2G5NK@200795|Chloroflexi	200795|Chloroflexi	H	Involved in the biosynthesis of porphyrin-containing compound	hemN	-	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
HKD2_k127_4847015_2	1382306.JNIM01000001_gene3732	2.874e-68	240.0	COG2755@1|root,COG2755@2|Bacteria	2|Bacteria	E	lipolytic protein G-D-S-L family	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
HKD2_k127_4847015_0	1382306.JNIM01000001_gene3731	0.0	1147.0	COG0577@1|root,COG0577@2|Bacteria,2G6CK@200795|Chloroflexi	200795|Chloroflexi	V	COGs COG4591 ABC-type transport system involved in lipoprotein release permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX
HKD2_k127_4847015_1	485913.Krac_7786	1.379e-75	256.0	COG1136@1|root,COG1136@2|Bacteria,2G6B5@200795|Chloroflexi	200795|Chloroflexi	V	COGs COG1136 ABC-type antimicrobial peptide transport system ATPase component	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD2_k127_4847039_1	1382306.JNIM01000001_gene3940	3.588e-18	85.0	COG0491@1|root,COG0491@2|Bacteria,2G7QF@200795|Chloroflexi	200795|Chloroflexi	S	PFAM beta-lactamase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HKD2_k127_4847039_0	485913.Krac_3637	2.453e-83	287.0	COG3336@1|root,COG3336@2|Bacteria,2G725@200795|Chloroflexi	200795|Chloroflexi	C	Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG)	-	-	-	-	-	-	-	-	-	-	-	-	Caa3_CtaG
HKD2_k127_4847039_2	485913.Krac_8653	3.625e-08	54.0	COG2001@1|root,COG2001@2|Bacteria,2G6ZC@200795|Chloroflexi	200795|Chloroflexi	K	Belongs to the MraZ family	mraZ	-	-	ko:K03925	-	-	-	-	ko00000	-	-	-	MraZ
HKD2_k127_4852078_0	1382306.JNIM01000001_gene3396	8.047e-166	525.0	COG2987@1|root,COG2987@2|Bacteria,2G5PQ@200795|Chloroflexi	200795|Chloroflexi	E	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate	hutU	-	4.2.1.49	ko:K01712	ko00340,ko01100,map00340,map01100	M00045	R02914	RC00804	ko00000,ko00001,ko00002,ko01000	-	-	-	Urocanase,Urocanase_C,Urocanase_N
HKD2_k127_4852078_1	485913.Krac_8409	2.133e-108	352.0	COG0493@1|root,COG0493@2|Bacteria	2|Bacteria	C	'glutamate synthase	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_20,Pyr_redox_2
HKD2_k127_485304_1	485913.Krac_2194	2.406e-47	174.0	COG1694@1|root,COG1694@2|Bacteria	2|Bacteria	FG	Mazg nucleotide pyrophosphohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	MazG
HKD2_k127_485304_2	1382306.JNIM01000001_gene3957	2.838e-14	72.0	COG0346@1|root,COG0346@2|Bacteria	2|Bacteria	E	lactoylglutathione lyase activity	-	-	4.4.1.5	ko:K01759	ko00620,map00620	-	R02530	RC00004,RC00740	ko00000,ko00001,ko01000	-	-	-	Glyoxalase
HKD2_k127_485304_0	485913.Krac_6225	4.843e-84	281.0	COG0500@1|root,COG2226@2|Bacteria,2G8IB@200795|Chloroflexi	200795|Chloroflexi	Q	PFAM Methyltransferase type 12	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
HKD2_k127_4858679_2	485913.Krac_8732	2.137e-83	279.0	COG1053@1|root,COG1053@2|Bacteria,2G5YB@200795|Chloroflexi	200795|Chloroflexi	C	PFAM fumarate reductase succinate dehydrogenase flavoprotein domain protein	-	-	1.3.5.1,1.3.5.4	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
HKD2_k127_4858679_0	485913.Krac_8733	6.451e-141	450.0	COG0479@1|root,COG0479@2|Bacteria,2G659@200795|Chloroflexi	200795|Chloroflexi	C	TIGRFAM succinate dehydrogenase and fumarate reductase iron-sulfur protein	-	-	1.3.5.1,1.3.5.4	ko:K00240	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_3,Fer4_10,Fer4_8
HKD2_k127_4858679_3	485913.Krac_8734	5.987e-35	138.0	COG0596@1|root,COG0596@2|Bacteria,2GA70@200795|Chloroflexi	200795|Chloroflexi	S	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
HKD2_k127_4858679_1	485913.Krac_8734	1.57e-89	298.0	COG0596@1|root,COG0596@2|Bacteria,2GA70@200795|Chloroflexi	200795|Chloroflexi	S	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
HKD2_k127_4903901_1	485913.Krac_8803	9.585e-109	357.0	COG0524@1|root,COG0524@2|Bacteria,2G6PQ@200795|Chloroflexi	200795|Chloroflexi	G	PFAM PfkB domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
HKD2_k127_4903901_0	1382306.JNIM01000001_gene4051	1.069e-112	372.0	COG1847@1|root,COG1847@2|Bacteria,2G6XH@200795|Chloroflexi	200795|Chloroflexi	S	PFAM single-stranded nucleic acid binding R3H domain protein	-	-	-	ko:K06346	-	-	-	-	ko00000	-	-	-	Jag_N,KH_4,R3H
HKD2_k127_4916860_0	485913.Krac_8230	5.171e-118	385.0	COG1562@1|root,COG1562@2|Bacteria,2G6KD@200795|Chloroflexi	200795|Chloroflexi	I	PFAM Squalene phytoene synthase	crtB	-	2.5.1.32,2.5.1.99	ko:K02291	ko00906,ko01062,ko01100,ko01110,map00906,map01062,map01100,map01110	M00097	R02065,R04218,R07270,R10177	RC00362,RC01101,RC02869	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	SQS_PSY
HKD2_k127_4917857_1	485913.Krac_12283	5.49e-45	181.0	COG3299@1|root,COG3299@2|Bacteria	2|Bacteria	S	Baseplate J-like protein	-	-	3.2.1.78	ko:K01218	ko00051,ko02024,map00051,map02024	-	R01332	RC00467	ko00000,ko00001,ko01000	-	GH26	-	Baseplate_J,CBM_3,CBM_4_9,Calx-beta,F5_F8_type_C,GSDH,PA14,fn3
HKD2_k127_4917857_0	485913.Krac_12284	2.653e-167	531.0	COG0849@1|root,COG0849@2|Bacteria	2|Bacteria	D	cell division	-	-	-	-	-	-	-	-	-	-	-	-	FtsA
HKD2_k127_4925986_1	1382306.JNIM01000001_gene617	4.783e-112	366.0	COG1686@1|root,COG1686@2|Bacteria	2|Bacteria	M	Belongs to the peptidase S11 family	-	-	3.4.16.4	ko:K07258	ko00550,ko01100,map00550,map01100	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	Beta-lactamase2,PG_binding_1,Peptidase_S11
HKD2_k127_4925986_0	485913.Krac_8021	2.557e-242	755.0	COG0773@1|root,COG0773@2|Bacteria,2GBNS@200795|Chloroflexi	200795|Chloroflexi	M	Domain of unknown function (DUF1727)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1727,Mur_ligase_M
HKD2_k127_4925986_2	1382306.JNIM01000001_gene3888	3.795e-60	212.0	COG2030@1|root,COG2030@2|Bacteria	2|Bacteria	I	dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydrat_N,MaoC_dehydratas
HKD2_k127_4935609_1	485913.Krac_11208	5.701e-21	93.0	COG2366@1|root,COG2366@2|Bacteria,2G63N@200795|Chloroflexi	200795|Chloroflexi	S	PFAM peptidase S45 penicillin amidase	-	-	3.5.1.11	ko:K01434	ko00311,ko01130,map00311,map01130	-	R02170	RC00166,RC00328	ko00000,ko00001,ko01000,ko01002	-	-	-	Penicil_amidase
HKD2_k127_4935609_0	1382306.JNIM01000001_gene664	9.692e-224	704.0	COG0215@1|root,COG0215@2|Bacteria,2G5Z0@200795|Chloroflexi	200795|Chloroflexi	J	Belongs to the class-I aminoacyl-tRNA synthetase family	-	-	-	-	-	-	-	-	-	-	-	-	tRNA-synt_1e
HKD2_k127_4945443_0	485913.Krac_8694	1.537e-123	401.0	COG2313@1|root,COG2313@2|Bacteria,2G5KC@200795|Chloroflexi	200795|Chloroflexi	Q	Catalyzes the reversible cleavage of pseudouridine 5'- phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway	psuG	-	4.2.1.70	ko:K16329	ko00240,map00240	-	R01055	RC00432,RC00433	ko00000,ko00001,ko01000	-	-	-	Indigoidine_A
HKD2_k127_4949256_0	485913.Krac_2298	5.785e-224	701.0	COG0174@1|root,COG0174@2|Bacteria,2G62E@200795|Chloroflexi	200795|Chloroflexi	E	Glutamine synthetase N-terminal domain	-	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N_2
HKD2_k127_4949329_0	485913.Krac_6563	1.416e-169	540.0	COG3677@1|root,COG3677@2|Bacteria,2G6SJ@200795|Chloroflexi	200795|Chloroflexi	L	PFAM Transposase IS66 family	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4949329_3	269797.Mbar_A2413	1.926e-10	69.0	COG3247@1|root,arCOG03582@2157|Archaea,2Y72H@28890|Euryarchaeota,2NB6I@224756|Methanomicrobia	224756|Methanomicrobia	S	Short repeat of unknown function (DUF308)	-	-	-	-	-	-	-	-	-	-	-	-	DUF308
HKD2_k127_4949329_1	1120973.AQXL01000130_gene1206	4.381e-120	401.0	COG1797@1|root,COG1797@2|Bacteria,1TNY2@1239|Firmicutes,4H9SN@91061|Bacilli,278VG@186823|Alicyclobacillaceae	91061|Bacilli	H	Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source	cbiA	-	6.3.5.11,6.3.5.9	ko:K02224	ko00860,ko01100,ko01120,map00860,map01100,map01120	-	R05224,R05815	RC00010,RC01301	ko00000,ko00001,ko01000	-	-	-	CbiA,GATase_3
HKD2_k127_4949329_2	697282.Mettu_2780	1.6e-39	156.0	COG2241@1|root,COG2241@2|Bacteria,1R5FK@1224|Proteobacteria	1224|Proteobacteria	H	Precorrin-6y C5,15-methyltransferase (Decarboxylating), CbiE subunit	cobL	-	2.1.1.132,2.1.1.289	ko:K00595,ko:K03399	ko00860,ko01100,map00860,map01100	-	R05149,R05813,R07775	RC00003,RC01279,RC02052,RC02053	ko00000,ko00001,ko01000	-	-	-	TP_methylase
HKD2_k127_495788_1	1382306.JNIM01000001_gene3304	2.828e-80	274.0	2DPJ9@1|root,332BI@2|Bacteria,2GBP4@200795|Chloroflexi	2|Bacteria	S	Domain of unknown function (DUF4397)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4397
HKD2_k127_495788_3	497965.Cyan7822_2372	8.32e-16	80.0	2DSH6@1|root,33G41@2|Bacteria,1GFI3@1117|Cyanobacteria,3KJ19@43988|Cyanothece	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_495788_2	323848.Nmul_A1780	7.103e-18	85.0	2EMYS@1|root,33FKY@2|Bacteria,1QZ0T@1224|Proteobacteria,2WHHF@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Protein of unknown function (DUF2795)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2795
HKD2_k127_495788_0	485913.Krac_7529	0.0	1040.0	COG0556@1|root,COG0556@2|Bacteria,2G5SU@200795|Chloroflexi	200795|Chloroflexi	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	-	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
HKD2_k127_4965729_0	485913.Krac_0957	1.189e-66	232.0	COG0123@1|root,COG0123@2|Bacteria,2G5X3@200795|Chloroflexi	200795|Chloroflexi	BQ	PFAM histone deacetylase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
HKD2_k127_4965729_1	420324.KI911939_gene5381	9.413e-58	213.0	COG3464@1|root,COG3464@2|Bacteria,1N2KA@1224|Proteobacteria,2TVCT@28211|Alphaproteobacteria,1JUSM@119045|Methylobacteriaceae	28211|Alphaproteobacteria	L	PFAM transposase IS204 IS1001 IS1096 IS1165 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_ISL3,HTH_Tnp_ISL3,zf-ISL3
HKD2_k127_4967415_2	485913.Krac_12111	2.364e-13	70.0	COG1022@1|root,COG1022@2|Bacteria,2G5S9@200795|Chloroflexi	200795|Chloroflexi	I	PFAM AMP-dependent synthetase and ligase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
HKD2_k127_4967415_0	485913.Krac_12112	2.096e-110	361.0	COG0313@1|root,COG0313@2|Bacteria,2G5VQ@200795|Chloroflexi	200795|Chloroflexi	H	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA	rsmI	-	2.1.1.198	ko:K07056	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TP_methylase
HKD2_k127_4967415_1	485913.Krac_12113	2.002e-60	226.0	COG1716@1|root,COG4995@1|root,COG1716@2|Bacteria,COG4995@2|Bacteria	2|Bacteria	S	CHAT domain	-	-	-	-	-	-	-	-	-	-	-	-	CHAT,FHA,GAF,TPR_12,Trans_reg_C,Yop-YscD_cpl
HKD2_k127_4973545_0	485913.Krac_8471	1.651e-156	510.0	COG0840@1|root,COG2203@1|root,COG0840@2|Bacteria,COG2203@2|Bacteria	2|Bacteria	T	Gaf domain	mcp40H-1	-	-	ko:K02660,ko:K03406,ko:K11525	ko02020,ko02025,ko02030,map02020,map02025,map02030	-	-	-	ko00000,ko00001,ko02035,ko02044	-	-	-	GAF,HAMP,MCPsignal,dCache_1
HKD2_k127_4984505_0	485913.Krac_11706	6.207e-187	590.0	COG0436@1|root,COG0436@2|Bacteria,2G5NH@200795|Chloroflexi	200795|Chloroflexi	E	aminotransferase class I and II	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
HKD2_k127_4984505_1	1382306.JNIM01000001_gene2761	1.284e-103	338.0	COG1809@1|root,COG1809@2|Bacteria	2|Bacteria	S	phosphosulfolactate synthase activity	-	-	-	-	-	-	-	-	-	-	-	-	ComA
HKD2_k127_4988315_10	485913.Krac_8820	8.278e-06	48.0	COG2146@1|root,COG2146@2|Bacteria,2G7AG@200795|Chloroflexi	200795|Chloroflexi	P	PFAM Rieske 2Fe-2S domain protein	-	-	1.7.1.15	ko:K00363,ko:K05710	ko00360,ko00910,ko01120,ko01220,map00360,map00910,map01120,map01220	M00530,M00545	R00787,R06782,R06783	RC00098,RC00176	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	Rieske
HKD2_k127_4988315_8	1382306.JNIM01000001_gene4002	2.989e-63	219.0	COG0822@1|root,COG0822@2|Bacteria,2G71H@200795|Chloroflexi	200795|Chloroflexi	C	SUF system FeS assembly protein, NifU family	-	-	-	ko:K04488	-	-	-	-	ko00000	-	-	-	NifU_N
HKD2_k127_4988315_2	485913.Krac_8822	4.195e-218	682.0	COG0520@1|root,COG0520@2|Bacteria,2G5T3@200795|Chloroflexi	200795|Chloroflexi	E	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine	-	-	2.8.1.7,4.4.1.16	ko:K11717	ko00450,ko01100,map00450,map01100	-	R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000	-	-	-	Aminotran_5
HKD2_k127_4988315_1	485913.Krac_8824	1.561e-224	704.0	COG0719@1|root,COG0719@2|Bacteria,2G5S8@200795|Chloroflexi	200795|Chloroflexi	O	TIGRFAM FeS assembly protein SufD	sufD	-	-	ko:K09015	-	-	-	-	ko00000	-	-	-	UPF0051
HKD2_k127_4988315_5	1382306.JNIM01000001_gene4005	3.243e-143	458.0	COG0396@1|root,COG0396@2|Bacteria,2G5S6@200795|Chloroflexi	200795|Chloroflexi	O	PFAM ABC transporter related	sufC	-	-	ko:K09013	-	-	-	-	ko00000,ko02000	-	-	-	ABC_tran
HKD2_k127_4988315_7	485913.Krac_8826	9.377e-78	264.0	COG1959@1|root,COG1959@2|Bacteria,2G8ZH@200795|Chloroflexi	200795|Chloroflexi	K	transcriptional regulator, Rrf2 family	-	-	-	-	-	-	-	-	-	-	-	-	Rrf2
HKD2_k127_4988315_0	485913.Krac_9160	1.306e-273	855.0	COG3854@1|root,COG3854@2|Bacteria,2G5P5@200795|Chloroflexi	200795|Chloroflexi	S	PFAM single-stranded nucleic acid binding R3H domain protein	-	-	-	-	-	-	-	-	-	-	-	-	AAA,AAA_30,R3H
HKD2_k127_4988315_3	485913.Krac_9161	5.74e-173	548.0	2E48V@1|root,32Z4P@2|Bacteria,2G7HY@200795|Chloroflexi	200795|Chloroflexi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4988315_6	485913.Krac_9162	1.442e-97	321.0	COG0311@1|root,COG0311@2|Bacteria,2G6JN@200795|Chloroflexi	200795|Chloroflexi	H	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS	pdxT	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008614,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0032991,GO:0034641,GO:0042364,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046184,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617,GO:1902494,GO:1903600	4.3.3.6	ko:K08681	ko00750,map00750	-	R07456	RC00010,RC01783,RC03043	ko00000,ko00001,ko01000	-	-	-	SNO
HKD2_k127_4988315_4	485913.Krac_9163	1.766e-169	535.0	COG0214@1|root,COG0214@2|Bacteria,2G5MW@200795|Chloroflexi	200795|Chloroflexi	H	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively	pdxS	-	4.3.3.6	ko:K06215	ko00750,map00750	-	R07456	RC00010,RC01783,RC03043	ko00000,ko00001,ko01000	-	-	-	SOR_SNZ
HKD2_k127_4988315_9	485913.Krac_6184	2.252e-07	56.0	28JEU@1|root,2Z98W@2|Bacteria	2|Bacteria	S	PFAM MULE transposase, conserved domain	-	-	-	-	-	-	-	-	-	-	-	-	MULE,Transposase_mut
HKD2_k127_5013948_0	1382306.JNIM01000001_gene2562	1.468e-167	540.0	COG0209@1|root,COG1372@1|root,COG0209@2|Bacteria,COG1372@2|Bacteria,2G5PW@200795|Chloroflexi	200795|Chloroflexi	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	nrdA	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Intein_splicing,Ribonuc_red_lgC,Ribonuc_red_lgN,TSCPD
HKD2_k127_5013948_1	1382306.JNIM01000001_gene2563	3.479e-95	317.0	COG1058@1|root,COG1058@2|Bacteria,2G6DU@200795|Chloroflexi	200795|Chloroflexi	S	PFAM molybdopterin binding domain	-	-	-	-	-	-	-	-	-	-	-	-	CinA,MoCF_biosynth
HKD2_k127_5017344_0	485913.Krac_6347	4.239e-109	359.0	COG0044@1|root,COG0044@2|Bacteria,2G5N4@200795|Chloroflexi	200795|Chloroflexi	F	Amidohydrolase family	-	-	3.5.2.2,3.5.2.5	ko:K01464,ko:K01466	ko00230,ko00240,ko00410,ko00770,ko00983,ko01100,ko01120,map00230,map00240,map00410,map00770,map00983,map01100,map01120	M00046,M00546	R02269,R02425,R03055,R08227	RC00632,RC00680	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Amidohydro_1
HKD2_k127_5017344_2	1128421.JAGA01000001_gene2233	4.276e-43	160.0	COG2351@1|root,COG2351@2|Bacteria	2|Bacteria	MU	hydroxyisourate hydrolase activity	uraH	GO:0003674,GO:0005488,GO:0005515,GO:0006139,GO:0006144,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009112,GO:0009987,GO:0034641,GO:0042802,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:1901360,GO:1901564	3.5.2.17,4.1.1.97	ko:K07127,ko:K13485	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R06601,R06604	RC01551,RC03393	ko00000,ko00001,ko00002,ko01000,ko02000	9.B.35.1.2,9.B.35.2	-	-	OHCU_decarbox,Transthyretin
HKD2_k127_5017344_1	485913.Krac_6351	1.526e-64	226.0	COG3195@1|root,COG3195@2|Bacteria,2G8S1@200795|Chloroflexi	200795|Chloroflexi	S	OHCU decarboxylase	-	-	-	-	-	-	-	-	-	-	-	-	OHCU_decarbox
HKD2_k127_502994_0	485913.Krac_10290	2.747e-239	749.0	COG0247@1|root,COG0247@2|Bacteria,2G5V8@200795|Chloroflexi	200795|Chloroflexi	C	4fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	ko:K11473	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	CCG,Fer4_8
HKD2_k127_502994_1	485913.Krac_10289	5.533e-138	447.0	COG2933@1|root,COG2933@2|Bacteria,2G6K6@200795|Chloroflexi	200795|Chloroflexi	J	FtsJ-like methyltransferase	-	-	2.1.1.186	ko:K06968	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ,THUMP
HKD2_k127_502994_2	485913.Krac_4399	9.071e-24	101.0	COG0675@1|root,COG0675@2|Bacteria	2|Bacteria	L	Transposase, IS605 OrfB family	-	-	-	ko:K07496	-	-	-	-	ko00000	-	-	-	OrfB_IS605,OrfB_Zn_ribbon
HKD2_k127_5047271_0	485913.Krac_4810	6.292e-136	438.0	COG2141@1|root,COG2141@2|Bacteria,2G8NG@200795|Chloroflexi	200795|Chloroflexi	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
HKD2_k127_5047271_2	1382306.JNIM01000001_gene3199	5.481e-42	161.0	COG3797@1|root,COG3797@2|Bacteria,2G9JY@200795|Chloroflexi	200795|Chloroflexi	S	Protein of unknown function (DUF1697)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1697
HKD2_k127_5067286_0	485913.Krac_7650	2.382e-52	186.0	COG0231@1|root,COG0231@2|Bacteria,2G6P4@200795|Chloroflexi	200795|Chloroflexi	J	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase	efp	GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K02356	-	-	-	-	ko00000,ko03012	-	-	-	EFP,EFP_N,Elong-fact-P_C
HKD2_k127_5067286_1	485913.Krac_7240	1.536e-44	172.0	COG0589@1|root,COG0589@2|Bacteria,2G768@200795|Chloroflexi	200795|Chloroflexi	T	Belongs to the universal stress protein A family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD2_k127_5073033_0	251221.35211731	1.218e-146	473.0	COG1063@1|root,COG1063@2|Bacteria	2|Bacteria	E	alcohol dehydrogenase	gcd	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N,Glu_dehyd_C
HKD2_k127_5073033_2	485913.Krac_3770	3.342e-21	93.0	COG3316@1|root,COG3316@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K07498	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS240
HKD2_k127_5073033_3	981369.JQMJ01000002_gene13	0.0003116	44.0	COG3316@1|root,COG3316@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K07498	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS240
HKD2_k127_5073033_1	1038859.AXAU01000030_gene6765	2.016e-48	177.0	COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,2TU7H@28211|Alphaproteobacteria,3JSWU@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	J	Amidase	-	-	3.5.1.4	ko:K01426	ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120	-	R02540,R03096,R03180,R03909,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000	-	-	-	Amidase
HKD2_k127_5077867_1	485913.Krac_7824	2.639e-60	213.0	COG0640@1|root,COG0640@2|Bacteria,2G7FZ@200795|Chloroflexi	200795|Chloroflexi	K	PFAM regulatory protein, ArsR	-	-	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	HTH_5
HKD2_k127_5077867_2	1382306.JNIM01000001_gene1291	1.064e-25	111.0	COG3794@1|root,COG3794@2|Bacteria	2|Bacteria	C	PFAM blue (type 1) copper domain protein	-	-	1.7.2.1	ko:K00368,ko:K02638	ko00195,ko00910,ko01120,map00195,map00910,map01120	M00529	R00783,R00785	RC00086	ko00000,ko00001,ko00002,ko00194,ko01000	-	-	-	CHRD,Copper-bind,Cu-oxidase_3,Cupredoxin_1
HKD2_k127_5077867_0	498761.HM1_1344	1.532e-226	727.0	COG0542@1|root,COG0542@2|Bacteria,1TPMU@1239|Firmicutes,247TD@186801|Clostridia	186801|Clostridia	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpC	-	-	ko:K03695,ko:K03696	ko01100,ko04213,map01100,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N,UVR
HKD2_k127_5103006_0	1195236.CTER_1812	2.949e-77	265.0	COG1131@1|root,COG1131@2|Bacteria,1TQUS@1239|Firmicutes,25AZ1@186801|Clostridia,3WH5S@541000|Ruminococcaceae	186801|Clostridia	V	ABC-type multidrug transport system ATPase component	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
HKD2_k127_5103006_1	335541.Swol_1722	5.61e-33	139.0	COG1277@1|root,COG1277@2|Bacteria,1V2H6@1239|Firmicutes,25F4G@186801|Clostridia	186801|Clostridia	S	ABC-2 family transporter protein	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane_2
HKD2_k127_5104957_5	1298880.AUEV01000001_gene5562	7.123e-08	61.0	COG0842@1|root,COG1131@1|root,COG1716@1|root,COG0842@2|Bacteria,COG1131@2|Bacteria,COG1716@2|Bacteria,2GKEU@201174|Actinobacteria	201174|Actinobacteria	V	ABC transporter	-	-	-	ko:K01990,ko:K21397	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane,ABC_tran,FHA,Yop-YscD_cpl
HKD2_k127_5104957_1	262316.MAP_2359c	4.616e-156	507.0	COG2041@1|root,COG4117@1|root,COG2041@2|Bacteria,COG4117@2|Bacteria,2GIZH@201174|Actinobacteria,235GI@1762|Mycobacteriaceae	201174|Actinobacteria	C	Prokaryotic cytochrome b561	-	-	-	-	-	-	-	-	-	-	-	-	Ni_hydr_CYTB,Oxidored_molyb
HKD2_k127_5104957_0	1382306.JNIM01000001_gene930	0.0	1026.0	COG0365@1|root,COG0365@2|Bacteria,2G7TW@200795|Chloroflexi	200795|Chloroflexi	I	PFAM AMP-dependent synthetase and ligase	-	-	6.2.1.16	ko:K01907	ko00280,ko00650,map00280,map00650	-	R01357	RC00004,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
HKD2_k127_5104957_4	443218.AS9A_2168	5.194e-08	60.0	COG3832@1|root,COG3832@2|Bacteria,2GVS1@201174|Actinobacteria	201174|Actinobacteria	S	Polyketide cyclase / dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
HKD2_k127_5104957_3	485913.Krac_12067	4.244e-35	137.0	COG5349@1|root,COG5349@2|Bacteria,2G7FQ@200795|Chloroflexi	200795|Chloroflexi	S	Protein of unknown function (DUF983)	-	-	-	-	-	-	-	-	-	-	-	-	DUF983
HKD2_k127_5104957_2	1122921.KB898191_gene2007	3.774e-43	164.0	COG0457@1|root,COG3210@1|root,COG5492@1|root,COG0457@2|Bacteria,COG3210@2|Bacteria,COG5492@2|Bacteria,1UI3P@1239|Firmicutes,4HJMZ@91061|Bacilli,27713@186822|Paenibacillaceae	2|Bacteria	GN	S-layer homology domain	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,Big_2,Cadherin-like,CarboxypepD_reg,Flg_new,Laminin_G_3,PATR,SLH,fn3
HKD2_k127_5106094_3	345341.KUTG_07539	5.488e-19	96.0	2DHBJ@1|root,32U91@2|Bacteria,2GPPB@201174|Actinobacteria,4EF37@85010|Pseudonocardiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5106094_0	56110.Oscil6304_5381	1.43e-87	305.0	COG1215@1|root,COG1215@2|Bacteria,1G44I@1117|Cyanobacteria,1HCCD@1150|Oscillatoriales	1117|Cyanobacteria	M	PFAM Glycosyl transferase family 2	-	-	2.4.1.80	ko:K00720	ko00600,ko01100,map00600,map01100	M00066	R01497	RC00005,RC00059	ko00000,ko00001,ko00002,ko01000,ko01003,ko02000	4.D.1.4	GT21	-	Glyco_transf_21
HKD2_k127_5106094_2	937777.Deipe_0157	7.793e-60	216.0	COG4221@1|root,COG4221@2|Bacteria,1WID9@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HKD2_k127_5106094_1	485913.Krac_0598	5.847e-72	244.0	COG1012@1|root,COG1012@2|Bacteria	2|Bacteria	C	belongs to the aldehyde dehydrogenase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldedh
HKD2_k127_5120761_1	485913.Krac_6742	1.702e-67	235.0	COG0472@1|root,COG0472@2|Bacteria,2G5TJ@200795|Chloroflexi	200795|Chloroflexi	M	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan	mraY	-	2.7.8.13	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	-	R05629,R05630	RC00002,RC02753	ko00000,ko00001,ko01000,ko01011	9.B.146	-	-	Glycos_transf_4,MraY_sig1
HKD2_k127_5120761_0	485913.Krac_6741	5.002e-157	500.0	COG0769@1|root,COG0769@2|Bacteria,2G5U3@200795|Chloroflexi	200795|Chloroflexi	M	Catalyzes the addition of an amino acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan	murE	-	6.3.2.13	ko:K01928	ko00300,ko00550,map00300,map00550	-	R02788	RC00064,RC00090	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
HKD2_k127_5135888_0	1382306.JNIM01000001_gene1287	1.336e-202	645.0	COG0771@1|root,COG0771@2|Bacteria,2GBHB@200795|Chloroflexi	200795|Chloroflexi	M	Domain of unknown function (DUF1727)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1727,Mur_ligase_M
HKD2_k127_5135888_1	485913.Krac_10927	1.687e-140	451.0	COG3442@1|root,COG3442@2|Bacteria,2G6KU@200795|Chloroflexi	200795|Chloroflexi	H	PFAM CobB CobQ domain protein glutamine amidotransferase	-	-	-	ko:K07009	-	-	-	-	ko00000	-	-	-	GATase_3
HKD2_k127_5135888_2	485913.Krac_10928	4.762e-86	289.0	COG1219@1|root,COG1219@2|Bacteria	2|Bacteria	O	unfolded protein binding	-	-	-	ko:K03544	ko04112,map04112	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA_2,TPR_4
HKD2_k127_5136726_1	485913.Krac_2996	1.325e-129	422.0	COG0667@1|root,COG0673@1|root,COG0667@2|Bacteria,COG0673@2|Bacteria,2G6AM@200795|Chloroflexi	200795|Chloroflexi	C	aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
HKD2_k127_5136726_0	1382306.JNIM01000001_gene1362	0.0	1047.0	COG0480@1|root,COG0480@2|Bacteria,2G680@200795|Chloroflexi	200795|Chloroflexi	J	elongation factor Tu domain 2 protein	-	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
HKD2_k127_5136726_4	1487921.DP68_14070	1.536e-06	51.0	29QV6@1|root,30BVB@2|Bacteria,1U8PC@1239|Firmicutes,252MJ@186801|Clostridia,36SRQ@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5136726_2	485913.Krac_7682	1.76e-94	312.0	COG0112@1|root,COG0112@2|Bacteria,2G624@200795|Chloroflexi	200795|Chloroflexi	H	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	-	-	-	-	-	-	-	-	-	-	-	-	SHMT
HKD2_k127_5154569_0	485913.Krac_7537	1.218e-122	397.0	COG1899@1|root,COG1899@2|Bacteria,2G9B5@200795|Chloroflexi	200795|Chloroflexi	O	Deoxyhypusine synthase	-	-	-	-	-	-	-	-	-	-	-	-	DS
HKD2_k127_5154569_1	1382306.JNIM01000001_gene1058	3.83e-38	147.0	COG0745@1|root,COG0745@2|Bacteria	1382306.JNIM01000001_gene1058|-	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5154569_2	485913.Krac_7529	4.192e-15	75.0	COG0556@1|root,COG0556@2|Bacteria,2G5SU@200795|Chloroflexi	200795|Chloroflexi	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	-	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
HKD2_k127_5202069_1	765911.Thivi_3764	1.163e-24	108.0	COG1523@1|root,COG1523@2|Bacteria,1R7FD@1224|Proteobacteria	1224|Proteobacteria	G	Alpha amylase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase
HKD2_k127_5202069_2	485913.Krac_1433	1.704e-20	96.0	COG3316@1|root,COG3316@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K18320	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS240
HKD2_k127_5202069_0	420324.KI911943_gene5256	2.559e-89	301.0	COG1404@1|root,COG1404@2|Bacteria,1MU3S@1224|Proteobacteria,2U4GD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Peptidase_S8
HKD2_k127_5209268_1	1449048.JQKU01000001_gene1935	1.646e-07	54.0	28Q0Z@1|root,2ZCJM@2|Bacteria,2IAZ4@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5209268_0	1120949.KB903294_gene3935	2.328e-89	322.0	COG4223@1|root,COG4223@2|Bacteria,2IRA0@201174|Actinobacteria	201174|Actinobacteria	M	COG3209 Rhs family protein	-	-	-	-	-	-	-	-	-	-	-	-	Collagen
HKD2_k127_5213646_0	485913.Krac_7854	5.479e-132	429.0	COG3829@1|root,COG3829@2|Bacteria	2|Bacteria	T	transcription factor binding	-	-	-	-	-	-	-	-	-	-	-	-	CBS,HTH_8,PAS,PAS_8,PAS_9,Sigma54_activat
HKD2_k127_5213646_1	1382306.JNIM01000001_gene873	7.328e-127	409.0	COG0303@1|root,COG0303@2|Bacteria,2G667@200795|Chloroflexi	200795|Chloroflexi	H	MoeA N-terminal region (domain I and II)	-	-	2.10.1.1	ko:K03750	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N
HKD2_k127_5218822_0	1382306.JNIM01000001_gene954	6.92e-53	189.0	COG5496@1|root,COG5496@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
HKD2_k127_5218822_2	485913.Krac_8566	6.376e-28	115.0	COG0582@1|root,COG0582@2|Bacteria,2G7XX@200795|Chloroflexi	200795|Chloroflexi	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_3,Phage_integrase
HKD2_k127_5218822_1	485913.Krac_6321	1.672e-28	116.0	COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria	2|Bacteria	L	Transposase	-	-	-	ko:K07494	-	-	-	-	ko00000	-	-	-	DDE_3,HTH_23,HTH_32,HTH_33
HKD2_k127_5234533_1	485913.Krac_8029	5.431e-48	175.0	COG1174@1|root,COG1174@2|Bacteria,2G8XF@200795|Chloroflexi	200795|Chloroflexi	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K05846	ko02010,map02010	M00209	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	BPD_transp_1
HKD2_k127_5234533_0	485913.Krac_8028	1.695e-162	517.0	COG1125@1|root,COG1125@2|Bacteria,2G7N7@200795|Chloroflexi	200795|Chloroflexi	P	PFAM ABC transporter related	-	-	-	ko:K05847	ko02010,map02010	M00209	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	ABC_tran
HKD2_k127_5235620_0	485913.Krac_7325	2.694e-102	343.0	COG0530@1|root,COG0530@2|Bacteria	2|Bacteria	P	calcium, potassium:sodium antiporter activity	-	-	-	ko:K07301	-	-	-	-	ko00000,ko02000	2.A.19.5	-	-	Na_Ca_ex
HKD2_k127_5263897_1	485913.Krac_7682	1.406e-199	625.0	COG0112@1|root,COG0112@2|Bacteria,2G624@200795|Chloroflexi	200795|Chloroflexi	H	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	-	-	-	-	-	-	-	-	-	-	-	-	SHMT
HKD2_k127_5263897_0	1382306.JNIM01000001_gene1364	2.292e-296	917.0	COG0272@1|root,COG0272@2|Bacteria,2G5TK@200795|Chloroflexi	200795|Chloroflexi	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5
HKD2_k127_5277885_2	1382306.JNIM01000001_gene1644	5.118e-66	229.0	COG1071@1|root,COG1071@2|Bacteria,2G6HY@200795|Chloroflexi	1382306.JNIM01000001_gene1644|-	C	PFAM dehydrogenase, E1 component	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5277885_0	1230476.C207_02434	8.019e-220	702.0	COG0369@1|root,COG2124@1|root,COG0369@2|Bacteria,COG2124@2|Bacteria,1MV75@1224|Proteobacteria,2TSV7@28211|Alphaproteobacteria,3JUN7@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	PQ	Flavodoxin	MA20_16700	-	1.14.14.1,1.6.2.4	ko:K14338	ko00071,ko00380,ko00627,ko01120,map00071,map00380,map00627,map01120	-	R03629,R04121,R05259	RC00046,RC01311	ko00000,ko00001,ko00199,ko01000	-	-	-	FAD_binding_1,Flavodoxin_1,NAD_binding_1,p450
HKD2_k127_5277885_1	886293.Sinac_6636	2.817e-126	417.0	COG0369@1|root,COG2124@1|root,COG0369@2|Bacteria,COG2124@2|Bacteria,2IYDG@203682|Planctomycetes	203682|Planctomycetes	C	Oxidoreductase NAD-binding domain	-	-	1.14.14.1,1.18.1.2,1.6.2.4,1.8.1.2	ko:K00380,ko:K02641,ko:K14338	ko00071,ko00195,ko00380,ko00627,ko00920,ko01100,ko01120,map00071,map00195,map00380,map00627,map00920,map01100,map01120	M00176	R00858,R03629,R04121,R05259	RC00046,RC00065,RC01311	ko00000,ko00001,ko00002,ko00194,ko00199,ko01000	-	-	-	FAD_binding_1,FeS,Flavodoxin_1,NAD_binding_1,p450
HKD2_k127_5284193_0	1382306.JNIM01000001_gene613	3.294e-221	692.0	COG0442@1|root,COG0442@2|Bacteria,2G636@200795|Chloroflexi	200795|Chloroflexi	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro)	proS	GO:0003674,GO:0003824,GO:0004812,GO:0004827,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006433,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017101,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,ProRS-C_1,tRNA-synt_2b
HKD2_k127_5286955_2	485913.Krac_6823	1.439e-25	106.0	COG4770@1|root,COG4770@2|Bacteria,2GBIE@200795|Chloroflexi	200795|Chloroflexi	I	Carbamoyl-phosphate synthetase large chain domain protein	-	-	6.4.1.4	ko:K01968	ko00280,ko01100,map00280,map01100	M00036	R04138	RC00367,RC00942	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2
HKD2_k127_5286955_0	485913.Krac_6822	1.312e-99	332.0	COG1024@1|root,COG1024@2|Bacteria,2G7Z4@200795|Chloroflexi	200795|Chloroflexi	I	PFAM Enoyl-CoA hydratase isomerase	-	-	4.2.1.18	ko:K13766	ko00280,ko01100,map00280,map01100	M00036	R02085	RC02416	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
HKD2_k127_5286955_1	357808.RoseRS_2408	9.386e-56	207.0	COG0598@1|root,COG0598@2|Bacteria,2G6EQ@200795|Chloroflexi,375MB@32061|Chloroflexia	32061|Chloroflexia	P	Mediates influx of magnesium ions	corA	-	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
HKD2_k127_5295728_1	485913.Krac_6637	2.039e-233	726.0	COG0243@1|root,COG0243@2|Bacteria,2G5X7@200795|Chloroflexi	200795|Chloroflexi	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
HKD2_k127_5295728_0	485913.Krac_6638	0.0	1267.0	COG0847@1|root,COG1199@1|root,COG0847@2|Bacteria,COG1199@2|Bacteria,2G5P4@200795|Chloroflexi	200795|Chloroflexi	L	PFAM Exonuclease, RNase T and DNA polymerase III	-	-	2.7.7.7,3.6.4.12	ko:K02342,ko:K03722	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DEAD,DEAD_2,Helicase_C_2,RNase_T
HKD2_k127_5295728_2	485913.Krac_6639	4.292e-85	287.0	COG0127@1|root,COG0127@2|Bacteria,2G6GK@200795|Chloroflexi	200795|Chloroflexi	F	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions	-	-	3.6.1.66	ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000	-	-	-	Ham1p_like
HKD2_k127_5306686_1	485913.Krac_10827	3.999e-05	49.0	COG2020@1|root,COG2020@2|Bacteria	2|Bacteria	O	methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
HKD2_k127_5306686_0	485913.Krac_12292	1.518e-66	241.0	COG0642@1|root,COG2205@2|Bacteria	485913.Krac_12292|-	T	PhoQ Sensor	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5308213_1	1382306.JNIM01000001_gene4010	1.453e-153	503.0	COG1376@1|root,COG1376@2|Bacteria	2|Bacteria	D	ErfK ybiS ycfS ynhG family protein	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2,YkuD
HKD2_k127_5308213_0	1382306.JNIM01000001_gene4011	4.333e-156	497.0	COG0541@1|root,COG0541@2|Bacteria,2G627@200795|Chloroflexi	200795|Chloroflexi	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY	ffh	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
HKD2_k127_5308503_1	485913.Krac_10883	7.322e-14	73.0	COG3336@1|root,COG3336@2|Bacteria	2|Bacteria	G	cytochrome c oxidase	ctaG	-	-	ko:K02351,ko:K02862	-	-	-	-	ko00000	-	-	-	Caa3_CtaG
HKD2_k127_5308503_0	1382306.JNIM01000001_gene2800	7.003e-105	356.0	COG1835@1|root,COG1835@2|Bacteria,2G7EM@200795|Chloroflexi	200795|Chloroflexi	I	PFAM acyltransferase 3	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
HKD2_k127_5331976_2	485913.Krac_11175	1.897e-128	417.0	COG0061@1|root,COG0061@2|Bacteria,2G6NK@200795|Chloroflexi	200795|Chloroflexi	F	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	nadK	-	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	NAD_kinase
HKD2_k127_5331976_0	357808.RoseRS_0119	1.094e-135	454.0	COG0497@1|root,COG0497@2|Bacteria,2G5V1@200795|Chloroflexi,375E5@32061|Chloroflexia	32061|Chloroflexia	L	May be involved in recombinational repair of damaged DNA	-	-	-	ko:K03631	-	-	-	-	ko00000,ko03400	-	-	-	SMC_N
HKD2_k127_5331976_1	485913.Krac_3462	2.95e-129	421.0	COG3380@1|root,COG3380@2|Bacteria,2G7AN@200795|Chloroflexi	200795|Chloroflexi	S	Flavin containing amine oxidoreductase	-	-	-	ko:K06955	-	-	-	-	ko00000	-	-	-	Amino_oxidase
HKD2_k127_5331976_3	1382306.JNIM01000001_gene3429	1.931e-110	366.0	COG0827@1|root,COG1002@1|root,COG0827@2|Bacteria,COG1002@2|Bacteria,2G6FJ@200795|Chloroflexi	200795|Chloroflexi	LV	Eco57I restriction-modification methylase	-	-	2.1.1.72	ko:K07317	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	Eco57I,TaqI_C
HKD2_k127_5334038_0	485913.Krac_10625	3.583e-291	901.0	COG1874@1|root,COG1874@2|Bacteria,2G604@200795|Chloroflexi	200795|Chloroflexi	G	PFAM Glycoside hydrolase family 42 domain protein	-	-	3.2.1.23	ko:K12308	ko00052,map00052	-	R01105	RC00452	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_42,Glyco_hydro_42C,Glyco_hydro_42M
HKD2_k127_5334648_1	485913.Krac_7964	1.098e-85	292.0	COG1529@1|root,COG1529@2|Bacteria,2G5NF@200795|Chloroflexi	200795|Chloroflexi	C	COGs COG1529 Aerobic-type carbon monoxide dehydrogenase large subunit CoxL CutL homologs	xdh	-	-	ko:K12528	ko00450,map00450	-	R07229	RC02420	ko00000,ko00001	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2,Fer2,Fer2_2
HKD2_k127_5339265_2	1382306.JNIM01000001_gene1517	5.195e-11	67.0	COG0366@1|root,COG3387@1|root,COG0366@2|Bacteria,COG3387@2|Bacteria,2G69A@200795|Chloroflexi	200795|Chloroflexi	G	glycoside hydrolase 15-related	-	-	3.2.1.3	ko:K01178	ko00500,ko01100,map00500,map01100	-	R01790,R01791,R06199	-	ko00000,ko00001,ko01000	-	GH15	-	Glucodextran_N,Glyco_hydro_15
HKD2_k127_5339265_0	485913.Krac_10641	1.343e-158	509.0	COG4214@1|root,COG4214@2|Bacteria	2|Bacteria	G	carbohydrate transport	-	-	-	ko:K10544	ko02010,map02010	M00215	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.4	-	-	BPD_transp_2
HKD2_k127_5339265_1	1382306.JNIM01000001_gene3205	3.771e-69	237.0	COG1129@1|root,COG1129@2|Bacteria,2G7M7@200795|Chloroflexi	200795|Chloroflexi	G	ATPases associated with a variety of cellular activities	-	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
HKD2_k127_5381228_0	1382306.JNIM01000001_gene1312	4.08e-187	600.0	COG5427@1|root,COG5427@2|Bacteria,2G6AA@200795|Chloroflexi	200795|Chloroflexi	S	Uncharacterized membrane protein (DUF2298)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2298
HKD2_k127_5384251_2	448385.sce2470	3.634e-11	68.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,42Q67@68525|delta/epsilon subdivisions,2WKZ1@28221|Deltaproteobacteria,2YUQ6@29|Myxococcales	28221|Deltaproteobacteria	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	AAA_16,Pkinase,TPR_12,zinc_ribbon_2
HKD2_k127_5384251_1	1382306.JNIM01000001_gene755	1.259e-34	141.0	COG1595@1|root,COG1595@2|Bacteria,2G6UE@200795|Chloroflexi	200795|Chloroflexi	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
HKD2_k127_5384251_0	485913.Krac_7185	4.739e-68	264.0	COG3629@1|root,COG3629@2|Bacteria,2G88E@200795|Chloroflexi	2|Bacteria	K	SPTR Q471D1 TPR repeat Bacterial transcriptional activator domain Tetratricopeptide TPR_4	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,BTAD,NACHT,NB-ARC,WD40
HKD2_k127_5388369_2	485913.Krac_5481	1.75e-22	100.0	COG2963@1|root,COG2963@2|Bacteria	2|Bacteria	L	transposase activity	-	-	-	ko:K07483,ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,HTH_Tnp_1,rve
HKD2_k127_5388369_0	264732.Moth_2229	7.662e-116	379.0	COG2801@1|root,COG2801@2|Bacteria,1TRNK@1239|Firmicutes,24B7I@186801|Clostridia,42G6M@68295|Thermoanaerobacterales	186801|Clostridia	L	HTH-like domain	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,HTH_Tnp_1,rve,rve_3
HKD2_k127_5388369_1	755731.Clo1100_3380	3.039e-101	338.0	COG3209@1|root,COG4733@1|root,COG3209@2|Bacteria,COG4733@2|Bacteria,1TR8F@1239|Firmicutes,248C6@186801|Clostridia,36F1J@31979|Clostridiaceae	186801|Clostridia	M	YD repeat (two copies)	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8,RHS_repeat
HKD2_k127_5399599_2	1382306.JNIM01000001_gene1519	4.465e-45	166.0	COG1102@1|root,COG1102@2|Bacteria	2|Bacteria	F	Psort location Cytoplasmic, score	-	-	2.7.4.25	ko:K00945	ko00240,ko01100,map00240,map01100	M00052	R00158,R00512,R01665	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytidylate_kin2
HKD2_k127_5399599_0	485913.Krac_2559	5.988e-125	406.0	COG1122@1|root,COG1122@2|Bacteria,2G6RD@200795|Chloroflexi	200795|Chloroflexi	P	ABC transporter	-	-	-	ko:K02006	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	ABC_tran
HKD2_k127_5399599_1	485913.Krac_2558	3.341e-115	377.0	COG0619@1|root,COG0619@2|Bacteria,2G7CE@200795|Chloroflexi	200795|Chloroflexi	P	TIGRFAM cobalt ABC transporter, inner membrane subunit CbiQ	cbiQ	-	-	ko:K02008	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	CbiQ
HKD2_k127_5402015_2	485913.Krac_10294	2.711e-38	147.0	COG1160@1|root,COG3597@1|root,COG1160@2|Bacteria,COG3597@2|Bacteria,2G9CM@200795|Chloroflexi	200795|Chloroflexi	S	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism	-	-	-	-	-	-	-	-	-	-	-	-	DUF697,MMR_HSR1
HKD2_k127_5402015_1	485913.Krac_10293	9.782e-106	348.0	290GX@1|root,2ZN5X@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5402015_0	1382306.JNIM01000001_gene1605	2.024e-129	418.0	COG0287@1|root,COG0287@2|Bacteria,2G6BW@200795|Chloroflexi	200795|Chloroflexi	E	NAD-dependent glycerol-3-phosphate dehydrogenase domain protein	-	-	1.3.1.12	ko:K04517	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	M00025	R01728	RC00125	ko00000,ko00001,ko00002,ko01000	-	-	-	PDH
HKD2_k127_5410405_2	485913.Krac_10870	1.298e-103	339.0	COG3290@1|root,COG3290@2|Bacteria	2|Bacteria	T	protein histidine kinase activity	exsG	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	GAF_2,GGDEF,HATPase_c,HWE_HK,HisKA_3,PAS,PAS_3,PAS_4,PAS_9,SpoIIE,dCache_1
HKD2_k127_5410405_1	485913.Krac_10869	3.564e-131	427.0	COG4191@1|root,COG4191@2|Bacteria,2G6UY@200795|Chloroflexi	200795|Chloroflexi	T	SMART ATP-binding region ATPase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_9
HKD2_k127_5410405_0	485913.Krac_10868	4.34e-138	450.0	COG0642@1|root,COG2205@2|Bacteria,2G8TT@200795|Chloroflexi	485913.Krac_10868|-	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5410405_3	485913.Krac_11872	1.26e-74	255.0	COG3385@1|root,COG3385@2|Bacteria,2G7KG@200795|Chloroflexi	200795|Chloroflexi	L	PFAM transposase, IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
HKD2_k127_5415727_2	485913.Krac_9920	8.739e-34	133.0	COG0695@1|root,COG0695@2|Bacteria,2G75B@200795|Chloroflexi	200795|Chloroflexi	O	Glutathione S-transferase, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Glutaredoxin
HKD2_k127_5415727_1	485913.Krac_1186	2.704e-55	196.0	COG1607@1|root,COG1607@2|Bacteria	2|Bacteria	I	acyl-coa hydrolase	-	-	4.3.1.14	ko:K18014	ko00310,map00310	-	R03030	RC00833	ko00000,ko00001,ko01000	-	-	-	4HBT
HKD2_k127_5415727_0	485913.Krac_6777	2.221e-89	303.0	COG3878@1|root,COG3878@2|Bacteria	2|Bacteria	J	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF1963
HKD2_k127_5425281_1	485913.Krac_7988	1.003e-32	127.0	COG1048@1|root,COG1048@2|Bacteria,2G5NG@200795|Chloroflexi	200795|Chloroflexi	C	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate	-	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
HKD2_k127_5425281_0	485913.Krac_1229	4.561e-137	458.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,2G7ZS@200795|Chloroflexi	200795|Chloroflexi	KLT	Serine threonine protein kinase	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_1,TPR_11,TPR_16,TPR_19,TPR_2,TPR_6,TPR_8
HKD2_k127_5437623_2	485913.Krac_2440	3.189e-34	133.0	COG2261@1|root,COG2261@2|Bacteria	2|Bacteria	S	Transglycosylase associated protein	MA20_01300	-	-	-	-	-	-	-	-	-	-	-	Transgly_assoc
HKD2_k127_5437623_0	1382306.JNIM01000001_gene1942	6.2e-95	323.0	COG0564@1|root,COG0564@2|Bacteria	2|Bacteria	J	pseudouridine synthase activity	rluD	GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,Rhodanese
HKD2_k127_5437623_3	266117.Rxyl_2924	7.337e-19	87.0	COG0531@1|root,COG0531@2|Bacteria,2GJ75@201174|Actinobacteria,4CPDM@84995|Rubrobacteria	84995|Rubrobacteria	E	PFAM amino acid permease-associated region	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
HKD2_k127_5442909_2	485913.Krac_1206	2.488e-91	306.0	COG0357@1|root,COG0357@2|Bacteria,2G6HF@200795|Chloroflexi	200795|Chloroflexi	J	Specifically methylates the N7 position of a guanine in 16S rRNA	rsmG	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036265,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070043,GO:0070475,GO:0070476,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.170	ko:K03501	-	-	-	-	ko00000,ko01000,ko03009,ko03036	-	-	-	GidB
HKD2_k127_5442909_0	1382306.JNIM01000001_gene1922	2.444e-243	756.0	COG0104@1|root,COG0104@2|Bacteria,2G602@200795|Chloroflexi	200795|Chloroflexi	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	-	-	-	-	-	-	-	-	-	-	-	-	Adenylsucc_synt
HKD2_k127_5442909_1	485913.Krac_1203	5.632e-98	323.0	COG4262@1|root,COG4262@2|Bacteria,2G5YS@200795|Chloroflexi	200795|Chloroflexi	S	Spermine/spermidine synthase domain	-	-	-	-	-	-	-	-	-	-	-	-	Spermine_synth
HKD2_k127_5443615_2	386456.JQKN01000007_gene3251	9.17e-70	243.0	arCOG02685@1|root,arCOG02685@2157|Archaea,2XV10@28890|Euryarchaeota	28890|Euryarchaeota	G	COG0477 Permeases of the major facilitator superfamily	csbC	-	-	-	-	-	-	-	-	-	-	-	Sugar_tr
HKD2_k127_5443615_0	485913.Krac_8508	1.079e-284	883.0	COG0696@1|root,COG0696@2|Bacteria,2G7GD@200795|Chloroflexi	200795|Chloroflexi	F	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate	gpmI	-	5.4.2.12	ko:K15633	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,Phosphodiest,iPGM_N
HKD2_k127_5443615_3	485913.Krac_8510	8.202e-31	121.0	COG1070@1|root,COG1070@2|Bacteria,2G6JV@200795|Chloroflexi	200795|Chloroflexi	G	Carbohydrate kinase	-	-	-	-	-	-	-	-	-	-	-	-	MutL
HKD2_k127_5456169_1	1382306.JNIM01000001_gene380	5.293e-84	298.0	COG0515@1|root,COG0515@2|Bacteria,2G67H@200795|Chloroflexi	200795|Chloroflexi	KLT	SMART serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HKD2_k127_5456664_0	485913.Krac_8170	7.577e-293	910.0	2BW99@1|root,2Z7PD@2|Bacteria	2|Bacteria	S	Psort location CytoplasmicMembrane, score	XK27_11280	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5456664_3	485913.Krac_11777	1.063e-46	171.0	COG4911@1|root,COG4911@2|Bacteria,2G7A8@200795|Chloroflexi	200795|Chloroflexi	S	Uncharacterized conserved protein (DUF2203)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2203
HKD2_k127_5456664_2	485913.Krac_11776	2.609e-99	331.0	COG2890@1|root,COG2890@2|Bacteria,2G6I8@200795|Chloroflexi	200795|Chloroflexi	J	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif	prmC	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0016740,GO:0016741,GO:0032259,GO:0044424,GO:0044444,GO:0044464	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS,Methyltransf_31
HKD2_k127_5456664_1	485913.Krac_11775	2.652e-124	409.0	COG0472@1|root,COG0472@2|Bacteria,2G6H5@200795|Chloroflexi	200795|Chloroflexi	M	PFAM Glycosyl transferase family 4	-	-	2.7.8.33,2.7.8.35	ko:K02851	-	-	R08856	RC00002	ko00000,ko01000,ko01003,ko01005	-	-	-	Glycos_transf_4
HKD2_k127_5460527_0	485913.Krac_6747	4.641e-202	637.0	COG1252@1|root,COG1252@2|Bacteria,2G5SS@200795|Chloroflexi	200795|Chloroflexi	C	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	1.6.99.3	ko:K03885	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
HKD2_k127_5460997_0	485913.Krac_10262	5.328e-178	578.0	COG1807@1|root,COG1807@2|Bacteria,2G9RP@200795|Chloroflexi	200795|Chloroflexi	M	Two component regulator propeller	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5460997_1	1382306.JNIM01000001_gene2710	4.15e-11	64.0	COG5542@1|root,COG5542@2|Bacteria,2G72S@200795|Chloroflexi	200795|Chloroflexi	S	integral membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	Mannosyl_trans2
HKD2_k127_5463348_3	1382306.JNIM01000001_gene448	2.017e-69	239.0	COG0631@1|root,COG0631@2|Bacteria,2G8RD@200795|Chloroflexi	200795|Chloroflexi	T	SMART protein phosphatase 2C domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PP2C
HKD2_k127_5463348_2	485913.Krac_12001	2.664e-118	385.0	COG0852@1|root,COG0852@2|Bacteria	2|Bacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoC	GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564	1.6.5.3	ko:K00332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	iAF987.Gmet_3353	Complex1_30kDa
HKD2_k127_5463348_0	1382306.JNIM01000001_gene451	1.194e-216	675.0	COG0649@1|root,COG0649@2|Bacteria,2G5JF@200795|Chloroflexi	200795|Chloroflexi	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoD	-	1.6.5.3	ko:K00333,ko:K13378	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa,Complex1_49kDa
HKD2_k127_5463348_1	485913.Krac_11998	7.298e-127	411.0	COG1005@1|root,COG1005@2|Bacteria,2G60S@200795|Chloroflexi	200795|Chloroflexi	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	nuoH	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
HKD2_k127_5465875_0	1382306.JNIM01000001_gene348	3.387e-272	846.0	COG0318@1|root,COG0318@2|Bacteria,2G5SX@200795|Chloroflexi	200795|Chloroflexi	IQ	AMP-binding enzyme C-terminal domain	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
HKD2_k127_5470067_1	869210.Marky_1274	4.055e-100	333.0	COG1541@1|root,COG1541@2|Bacteria,1WJ2G@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	H	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)	-	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006082,GO:0006725,GO:0006805,GO:0008144,GO:0008150,GO:0008152,GO:0009056,GO:0009404,GO:0009407,GO:0009410,GO:0009636,GO:0009850,GO:0009852,GO:0009987,GO:0010124,GO:0010817,GO:0016054,GO:0016405,GO:0016874,GO:0016877,GO:0016878,GO:0017076,GO:0019439,GO:0019748,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0035639,GO:0036094,GO:0042178,GO:0042221,GO:0042445,GO:0042447,GO:0042537,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0047475,GO:0050896,GO:0051716,GO:0065007,GO:0065008,GO:0070887,GO:0071466,GO:0071704,GO:0072329,GO:0097159,GO:0097367,GO:0098754,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901575	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C_2
HKD2_k127_5470067_0	1382306.JNIM01000001_gene3380	1.358e-156	503.0	COG0624@1|root,COG0624@2|Bacteria,2G5V4@200795|Chloroflexi	200795|Chloroflexi	E	Peptidase dimerisation domain	-	-	3.4.17.11	ko:K01295	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20
HKD2_k127_5470067_2	518766.Rmar_0949	5.907e-42	164.0	COG1763@1|root,COG1763@2|Bacteria,4PM6G@976|Bacteroidetes,1FK05@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	H	Mo-molybdopterin cofactor biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5470917_0	485913.Krac_12256	1.758e-197	622.0	COG1012@1|root,COG1012@2|Bacteria,2G5JZ@200795|Chloroflexi	200795|Chloroflexi	C	Belongs to the aldehyde dehydrogenase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldedh
HKD2_k127_5484666_0	1382306.JNIM01000001_gene1104	4.11e-110	361.0	COG0515@1|root,COG0515@2|Bacteria	1382306.JNIM01000001_gene1104|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5484666_1	485913.Krac_7983	5.373e-53	193.0	COG0515@1|root,COG0515@2|Bacteria	485913.Krac_7983|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5484894_4	485913.Krac_12405	2.14e-08	55.0	COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,2G816@200795|Chloroflexi	2|Bacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_29,HTH_32
HKD2_k127_5484894_3	485913.Krac_12120	1.198e-80	284.0	COG0438@1|root,COG1216@1|root,COG0438@2|Bacteria,COG1216@2|Bacteria,2G6R5@200795|Chloroflexi	200795|Chloroflexi	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HKD2_k127_5484894_1	485913.Krac_12119	9.62e-94	324.0	COG2244@1|root,COG2244@2|Bacteria	2|Bacteria	S	polysaccharide biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt,Polysacc_synt_3,Polysacc_synt_C
HKD2_k127_5484894_2	485913.Krac_12117	1.371e-81	280.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	sigV	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
HKD2_k127_5484894_0	485913.Krac_10254	5.064e-128	419.0	COG0628@1|root,COG0628@2|Bacteria,2G6TV@200795|Chloroflexi	200795|Chloroflexi	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
HKD2_k127_5488409_1	797209.ZOD2009_18744	0.0001465	50.0	COG3548@1|root,arCOG04887@2157|Archaea,2XUMU@28890|Euryarchaeota,23UZ5@183963|Halobacteria	183963|Halobacteria	S	integral membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF1211
HKD2_k127_5488409_0	485913.Krac_8104	2.548e-12	66.0	COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,2G816@200795|Chloroflexi	200795|Chloroflexi	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3
HKD2_k127_5502613_1	315730.BcerKBAB4_0549	3.531e-11	73.0	COG1266@1|root,COG1266@2|Bacteria,1UUMR@1239|Firmicutes,4HDXH@91061|Bacilli,1ZJMT@1386|Bacillus	91061|Bacilli	S	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
HKD2_k127_5502613_0	448385.sce4638	7.759e-85	286.0	COG3448@1|root,COG3448@2|Bacteria,1MYEK@1224|Proteobacteria	1224|Proteobacteria	T	HPP family	-	-	-	-	-	-	-	-	-	-	-	-	HPP
HKD2_k127_5512390_1	485913.Krac_3162	8.302e-50	183.0	COG1073@1|root,COG1073@2|Bacteria,2G8PF@200795|Chloroflexi	200795|Chloroflexi	S	X-Pro dipeptidyl-peptidase (S15 family)	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4
HKD2_k127_5512390_0	251221.35213287	1.837e-55	209.0	COG3594@1|root,COG3594@2|Bacteria	2|Bacteria	G	nodulation	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
HKD2_k127_5512390_2	1382306.JNIM01000001_gene1696	2.341e-43	164.0	COG0071@1|root,COG0071@2|Bacteria	2|Bacteria	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
HKD2_k127_5512390_3	386456.JQKN01000016_gene905	2.814e-19	88.0	COG1917@1|root,arCOG03004@2157|Archaea,2XYUR@28890|Euryarchaeota,23P5U@183925|Methanobacteria	183925|Methanobacteria	S	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HKD2_k127_5519958_0	1382306.JNIM01000001_gene3305	7.587e-53	190.0	COG3764@1|root,COG3764@2|Bacteria,2G77W@200795|Chloroflexi	200795|Chloroflexi	M	peptidase C60 sortase A and B	-	-	-	-	-	-	-	-	-	-	-	-	Sortase
HKD2_k127_5543998_0	502025.Hoch_2100	6.964e-129	419.0	COG4770@1|root,COG4799@1|root,COG4770@2|Bacteria,COG4799@2|Bacteria,1P6RE@1224|Proteobacteria,43A2M@68525|delta/epsilon subdivisions,2X1XW@28221|Deltaproteobacteria,2YX2T@29|Myxococcales	28221|Deltaproteobacteria	I	Acetyl-CoA carboxylase, central region	-	-	-	-	-	-	-	-	-	-	-	-	ACC_central,Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2,Carboxyl_trans
HKD2_k127_5543998_1	1382306.JNIM01000001_gene3932	3.344e-85	289.0	COG0664@1|root,COG0664@2|Bacteria,2G6XU@200795|Chloroflexi	200795|Chloroflexi	K	PFAM Cyclic nucleotide-binding	-	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
HKD2_k127_5543998_3	1382306.JNIM01000001_gene3933	7.313e-27	112.0	COG4309@1|root,COG4309@2|Bacteria	2|Bacteria	D	conserved protein (DUF2249)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1858,DUF2249
HKD2_k127_5543998_2	1382306.JNIM01000001_gene3938	8.374e-64	227.0	2DBT9@1|root,32TY2@2|Bacteria,2G95T@200795|Chloroflexi	200795|Chloroflexi	-	-	-	-	-	ko:K07234	-	-	-	-	ko00000	-	-	-	-
HKD2_k127_5546744_1	485913.Krac_11942	1.229e-37	143.0	COG1087@1|root,COG1087@2|Bacteria,2GA96@200795|Chloroflexi	200795|Chloroflexi	M	3-beta hydroxysteroid dehydrogenase/isomerase family	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
HKD2_k127_5551300_0	485913.Krac_6676	7.113e-255	793.0	COG0477@1|root,COG0477@2|Bacteria	2|Bacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_3
HKD2_k127_5551300_1	1382306.JNIM01000001_gene1042	1.462e-221	692.0	COG1251@1|root,COG1251@2|Bacteria,2G6YZ@200795|Chloroflexi	200795|Chloroflexi	C	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2
HKD2_k127_5562455_2	485913.Krac_10045	4.144e-50	181.0	2ADVU@1|root,313MT@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5562455_1	485913.Krac_10046	1.016e-90	302.0	29Z4R@1|root,30M2D@2|Bacteria,2G8VE@200795|Chloroflexi	200795|Chloroflexi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5562455_0	485913.Krac_10047	4.593e-104	347.0	COG0680@1|root,COG0680@2|Bacteria	2|Bacteria	C	spore germination	-	-	-	ko:K03605	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	HycI
HKD2_k127_5562455_3	485913.Krac_10047	3.891e-42	156.0	COG0680@1|root,COG0680@2|Bacteria	2|Bacteria	C	spore germination	-	-	-	ko:K03605	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	HycI
HKD2_k127_5564396_1	1382306.JNIM01000001_gene3493	1.354e-56	203.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
HKD2_k127_5564396_0	485913.Krac_11836	3.203e-118	389.0	COG2146@1|root,COG2146@2|Bacteria	2|Bacteria	P	nitrite reductase [NAD(P)H] activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF2231,Hemerythrin,Rieske
HKD2_k127_5570626_0	485913.Krac_6820	6.4e-323	994.0	COG4799@1|root,COG4799@2|Bacteria,2G61R@200795|Chloroflexi	200795|Chloroflexi	I	PFAM carboxyl transferase	-	-	2.1.3.15,6.4.1.3,6.4.1.4	ko:K01969,ko:K15052	ko00280,ko00720,ko01100,ko01200,map00280,map00720,map01100,map01200	M00036,M00376	R01859,R04138	RC00097,RC00367,RC00609,RC00942	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
HKD2_k127_5574445_2	485913.Krac_9111	3.242e-36	140.0	COG0607@1|root,COG0607@2|Bacteria	2|Bacteria	P	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS	yibN	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	2.8.1.1,2.8.1.2	ko:K01011,ko:K02439	ko00270,ko00920,ko01100,ko01110,ko01120,ko04122,map00270,map00920,map01100,map01110,map01120,map04122	-	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko01000	-	-	-	Rhodanese
HKD2_k127_5574445_1	485913.Krac_9110	1.505e-127	414.0	COG0623@1|root,COG0623@2|Bacteria,2G6ED@200795|Chloroflexi	200795|Chloroflexi	I	Enoyl- acyl-carrier-protein reductase NADH	fabI	-	1.3.1.10,1.3.1.9	ko:K00208	ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212	M00083,M00572	R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671	RC00052,RC00076,RC00120	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HKD2_k127_5574445_0	485913.Krac_9108	6.925e-147	482.0	COG0265@1|root,COG0265@2|Bacteria	2|Bacteria	O	serine-type endopeptidase activity	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	Trypsin_2
HKD2_k127_5584365_0	1382306.JNIM01000001_gene380	2.471e-73	255.0	COG0515@1|root,COG0515@2|Bacteria,2G67H@200795|Chloroflexi	200795|Chloroflexi	KLT	SMART serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HKD2_k127_5584365_1	1382306.JNIM01000001_gene380	1.24e-34	151.0	COG0515@1|root,COG0515@2|Bacteria,2G67H@200795|Chloroflexi	200795|Chloroflexi	KLT	SMART serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HKD2_k127_5594509_2	1382306.JNIM01000001_gene524	2.796e-45	166.0	COG0537@1|root,COG0537@2|Bacteria,2G6VV@200795|Chloroflexi	200795|Chloroflexi	FG	PFAM histidine triad (HIT) protein	-	-	-	ko:K02503	-	-	-	-	ko00000,ko04147	-	-	-	HIT
HKD2_k127_5594509_0	485913.Krac_11743	7.821e-178	563.0	COG0438@1|root,COG0438@2|Bacteria,2G61I@200795|Chloroflexi	200795|Chloroflexi	M	PFAM glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
HKD2_k127_5603020_2	1382306.JNIM01000001_gene396	8.187e-50	181.0	COG3942@1|root,COG3942@2|Bacteria,2GBP7@200795|Chloroflexi	2|Bacteria	S	CHAP domain	-	-	-	ko:K21471	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	CHAP,GBS_Bsp-like
HKD2_k127_5603020_1	1382306.JNIM01000001_gene396	6.26e-60	218.0	COG3942@1|root,COG3942@2|Bacteria,2GBP7@200795|Chloroflexi	2|Bacteria	S	CHAP domain	-	-	-	ko:K21471	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	CHAP,GBS_Bsp-like
HKD2_k127_5603020_0	479434.Sthe_2225	1.011e-134	446.0	COG1167@1|root,COG1167@2|Bacteria,2G5XE@200795|Chloroflexi,27Y0D@189775|Thermomicrobia	189775|Thermomicrobia	EK	Alanine-glyoxylate amino-transferase	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2,GntR
HKD2_k127_5627867_1	485913.Krac_12034	7.15e-100	335.0	COG1664@1|root,COG1664@2|Bacteria,2G7EZ@200795|Chloroflexi	200795|Chloroflexi	M	Polymer-forming cytoskeletal	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
HKD2_k127_5627867_0	485913.Krac_12035	2.162e-248	772.0	COG2265@1|root,COG2265@2|Bacteria,2G6IV@200795|Chloroflexi	200795|Chloroflexi	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family	-	-	2.1.1.190	ko:K03215	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TRAM,tRNA_U5-meth_tr
HKD2_k127_5633182_1	357808.RoseRS_2166	3.419e-119	390.0	COG0714@1|root,COG0714@2|Bacteria,2G5WI@200795|Chloroflexi,37710@32061|Chloroflexia	32061|Chloroflexia	S	PFAM ATPase associated with various cellular activities, AAA_5	-	-	-	-	-	-	-	-	-	-	-	-	AAA_5
HKD2_k127_5633182_0	485913.Krac_10573	4.636e-176	559.0	COG2309@1|root,COG2309@2|Bacteria,2G5TH@200795|Chloroflexi	200795|Chloroflexi	E	PFAM peptidase M29, aminopeptidase II	-	-	-	ko:K19689	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M29
HKD2_k127_5633182_4	1382306.JNIM01000001_gene2693	6.004e-34	132.0	COG1319@1|root,COG1319@2|Bacteria,2G60Y@200795|Chloroflexi	200795|Chloroflexi	C	CO dehydrogenase flavoprotein domain protein	-	-	1.2.5.3	ko:K03519	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
HKD2_k127_5633182_2	485913.Krac_10571	6.03e-80	270.0	COG1319@1|root,COG1319@2|Bacteria,2G60Y@200795|Chloroflexi	200795|Chloroflexi	C	CO dehydrogenase flavoprotein domain protein	-	-	1.2.5.3	ko:K03519	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
HKD2_k127_5633182_3	1382306.JNIM01000001_gene2694	2.542e-60	210.0	COG1529@1|root,COG1529@2|Bacteria,2G608@200795|Chloroflexi	200795|Chloroflexi	C	aldehyde oxidase and xanthine dehydrogenase, a b hammerhead	-	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
HKD2_k127_5654924_2	102125.Xen7305DRAFT_00049660	5.389e-23	100.0	COG4913@1|root,COG4913@2|Bacteria	2|Bacteria	D	Putative exonuclease SbcCD, C subunit	-	-	-	-	-	-	-	-	-	-	-	-	AAA_29,SbcCD_C
HKD2_k127_5654924_1	497965.Cyan7822_1787	8.308e-103	347.0	COG4924@1|root,COG4924@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF2220,DUF3322
HKD2_k127_5654924_0	485913.Krac_10741	2.139e-175	557.0	28HTA@1|root,2Z806@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5658847_0	485913.Krac_12134	3.557e-199	629.0	COG0644@1|root,COG0644@2|Bacteria,2G81U@200795|Chloroflexi	200795|Chloroflexi	C	oxidoreductase	-	-	5.5.1.19	ko:K14605	ko00906,ko01100,ko01110,map00906,map01100,map01110	-	R03824,R05341	RC01004	ko00000,ko00001,ko01000	-	-	-	-
HKD2_k127_5658847_1	485913.Krac_12132	4.465e-16	81.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_23,Methyltransf_25
HKD2_k127_5662751_1	485913.Krac_9218	2.959e-126	409.0	COG0030@1|root,COG0030@2|Bacteria,2G6DA@200795|Chloroflexi	200795|Chloroflexi	J	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	-	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
HKD2_k127_5662751_0	485913.Krac_9219	1.559e-168	534.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria	485913.Krac_9219|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_567884_0	485913.Krac_10173	1.873e-108	357.0	COG0483@1|root,COG0483@2|Bacteria	2|Bacteria	G	inositol monophosphate 1-phosphatase activity	-	-	3.1.3.25,3.1.3.7	ko:K01082,ko:K01092	ko00521,ko00562,ko00920,ko01100,ko01120,ko01130,ko04070,map00521,map00562,map00920,map01100,map01120,map01130,map04070	M00131	R00188,R00508,R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	Inositol_P
HKD2_k127_567884_1	485913.Krac_10164	1.028e-86	289.0	COG2189@1|root,COG2189@2|Bacteria,2G5WR@200795|Chloroflexi	200795|Chloroflexi	H	PFAM DNA methylase N-4 N-6 domain protein	-	-	2.1.1.72	ko:K00571,ko:K07316	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
HKD2_k127_5692304_0	1382306.JNIM01000001_gene1358	3.123e-166	531.0	COG0215@1|root,COG1216@1|root,COG0215@2|Bacteria,COG1216@2|Bacteria,2G5Z0@200795|Chloroflexi	2|Bacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e
HKD2_k127_5701223_2	485913.Krac_8294	6.942e-98	326.0	COG0183@1|root,COG0183@2|Bacteria,2G80D@200795|Chloroflexi	200795|Chloroflexi	I	Belongs to the thiolase family	-	-	2.3.1.16,2.3.1.9	ko:K00626,ko:K00632	ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00087,M00088,M00095,M00113,M00373,M00374,M00375	R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
HKD2_k127_5701223_3	485913.Krac_8323	4.15e-72	265.0	COG5002@1|root,COG5002@2|Bacteria,2G8WY@200795|Chloroflexi	200795|Chloroflexi	T	His Kinase A (phosphoacceptor) domain	-	-	2.7.13.3	ko:K02482	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	GAF_2,HATPase_c,HisKA,PAS_9
HKD2_k127_5701223_0	485913.Krac_8325	1.006e-141	457.0	COG2348@1|root,COG2348@2|Bacteria,2G6KK@200795|Chloroflexi	200795|Chloroflexi	V	PFAM Methicillin resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	FemAB
HKD2_k127_5701223_4	1382306.JNIM01000001_gene386	1.825e-58	206.0	COG0569@1|root,COG0569@2|Bacteria,2G71A@200795|Chloroflexi	200795|Chloroflexi	C	PFAM TrkA-N domain protein	-	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_N
HKD2_k127_5701223_1	485913.Krac_8327	6.715e-103	338.0	COG0569@1|root,COG0569@2|Bacteria,2G6J8@200795|Chloroflexi	200795|Chloroflexi	C	PFAM TrkA-N domain protein	-	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
HKD2_k127_5701223_6	485913.Krac_8328	1.197e-07	55.0	COG0628@1|root,COG0628@2|Bacteria,2G6TV@200795|Chloroflexi	200795|Chloroflexi	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
HKD2_k127_5713214_2	1382306.JNIM01000001_gene3008	9.675e-21	93.0	COG0239@1|root,COG0239@2|Bacteria,2G760@200795|Chloroflexi	200795|Chloroflexi	D	Important for reducing fluoride concentration in the cell, thus reducing its toxicity	crcB	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661,GO:1903424,GO:1903425	-	ko:K06199	-	-	-	-	ko00000,ko02000	1.A.43.1,1.A.43.2,1.A.43.3	-	-	CRCB
HKD2_k127_5713214_1	485913.Krac_10859	1.025e-36	144.0	COG0239@1|root,COG0239@2|Bacteria,2G760@200795|Chloroflexi	200795|Chloroflexi	D	Important for reducing fluoride concentration in the cell, thus reducing its toxicity	-	-	-	-	-	-	-	-	-	-	-	-	CRCB
HKD2_k127_5713214_0	1382306.JNIM01000001_gene2642	2.609e-99	331.0	COG0672@1|root,COG0672@2|Bacteria	2|Bacteria	P	high-affinity ferrous iron transmembrane transporter activity	efeU	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K07243	-	-	-	-	ko00000,ko02000	2.A.108.1,2.A.108.2	-	-	FTR1,Peptidase_M75
HKD2_k127_5720200_0	479434.Sthe_3176	9.156e-225	704.0	COG2192@1|root,COG2192@2|Bacteria	2|Bacteria	O	nodulation	-	-	-	ko:K00612	-	-	-	-	ko00000,ko01000	-	-	-	Carbam_trans_C,Carbam_trans_N
HKD2_k127_5720200_2	479434.Sthe_3175	1.777e-115	380.0	COG1215@1|root,COG1215@2|Bacteria,2GBB7@200795|Chloroflexi,27YX2@189775|Thermomicrobia	189775|Thermomicrobia	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HKD2_k127_5720200_1	479434.Sthe_3174	1.279e-134	434.0	COG0535@1|root,COG0535@2|Bacteria,2G75Y@200795|Chloroflexi	200795|Chloroflexi	C	Iron-sulfur cluster-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_14,Radical_SAM,SPASM
HKD2_k127_5738827_0	485913.Krac_3494	4.795e-224	698.0	COG1486@1|root,COG1486@2|Bacteria,2G5KA@200795|Chloroflexi	200795|Chloroflexi	G	Family 4 glycosyl hydrolase	-	-	3.2.1.22	ko:K07406	ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603	-	R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05549,R05961,R06091	RC00049,RC00059,RC00451	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_4,Glyco_hydro_4C
HKD2_k127_5738827_1	485913.Krac_5019	1.358e-44	164.0	COG2261@1|root,COG2261@2|Bacteria,2G9IB@200795|Chloroflexi	200795|Chloroflexi	S	PFAM Transglycosylase-associated protein	-	-	-	-	-	-	-	-	-	-	-	-	Transgly_assoc
HKD2_k127_5738827_2	485913.Krac_0916	2.024e-28	116.0	COG1961@1|root,COG1961@2|Bacteria,2G7BH@200795|Chloroflexi	200795|Chloroflexi	L	COGs COG1961 Site-specific recombinase DNA invertase Pin homologs	-	-	-	ko:K06400	-	-	-	-	ko00000	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
HKD2_k127_5738827_3	485913.Krac_8104	3.989e-06	49.0	COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,2G816@200795|Chloroflexi	200795|Chloroflexi	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3
HKD2_k127_5754562_0	485913.Krac_6466	8.795e-202	632.0	COG5433@1|root,COG5433@2|Bacteria,2G91M@200795|Chloroflexi	200795|Chloroflexi	L	PFAM transposase, IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_assoc
HKD2_k127_5755138_0	485913.Krac_6708	1.889e-117	389.0	COG0642@1|root,COG2114@1|root,COG2114@2|Bacteria,COG2205@2|Bacteria,2G6X8@200795|Chloroflexi	200795|Chloroflexi	T	adenylyl cyclase class-3 4 guanylyl cyclase	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	FHA,GAF_2,GAF_3,Guanylate_cyc,PAS
HKD2_k127_5768793_0	485913.Krac_0975	4.047e-120	396.0	COG1807@1|root,COG1807@2|Bacteria	2|Bacteria	M	4-amino-4-deoxy-L-arabinose transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF2298,PMT,PMT_2
HKD2_k127_5768793_1	485913.Krac_9959	9.293e-72	249.0	COG2730@1|root,COG5297@1|root,COG2730@2|Bacteria,COG5297@2|Bacteria,2G8G7@200795|Chloroflexi	200795|Chloroflexi	G	PFAM glycoside hydrolase family 5	-	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	CBM_3,Cellulase
HKD2_k127_5789791_0	485913.Krac_10262	1.198e-107	358.0	COG1807@1|root,COG1807@2|Bacteria,2G9RP@200795|Chloroflexi	200795|Chloroflexi	M	Two component regulator propeller	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5790095_0	485913.Krac_0957	2.424e-162	517.0	COG0123@1|root,COG0123@2|Bacteria,2G5X3@200795|Chloroflexi	200795|Chloroflexi	BQ	PFAM histone deacetylase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
HKD2_k127_5805890_0	485913.Krac_4638	2.191e-124	407.0	2DBVK@1|root,2ZBBH@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Ion_trans_2
HKD2_k127_5805890_1	485913.Krac_0275	7.006e-117	382.0	COG1028@1|root,COG1028@2|Bacteria,2G660@200795|Chloroflexi	200795|Chloroflexi	IQ	COGs COG1028 Dehydrogenase with different specificities (related to short-chain alcohol dehydrogenase)	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HKD2_k127_5805890_2	485913.Krac_10665	2.51e-75	261.0	COG0684@1|root,COG0684@2|Bacteria,2G8I8@200795|Chloroflexi	200795|Chloroflexi	H	PFAM Dimethylmenaquinone methyltransferase	-	-	4.1.3.17	ko:K10218	ko00362,ko00660,ko01120,map00362,map00660,map01120	-	R00008,R00350	RC00067,RC00502,RC01205	ko00000,ko00001,ko01000	-	-	-	RraA-like
HKD2_k127_5811076_1	485913.Krac_7826	6.105e-193	632.0	COG0631@1|root,COG0631@2|Bacteria,2G6R4@200795|Chloroflexi	200795|Chloroflexi	T	SMART protein phosphatase 2C domain protein	-	-	3.1.3.16	ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C,PP2C_2
HKD2_k127_5811076_0	485913.Krac_7825	5.502e-312	964.0	COG0173@1|root,COG0173@2|Bacteria,2G5RX@200795|Chloroflexi	200795|Chloroflexi	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
HKD2_k127_581190_0	1382306.JNIM01000001_gene3887	1.425e-119	389.0	COG1028@1|root,COG1028@2|Bacteria	1382306.JNIM01000001_gene3887|-	IQ	oxidoreductase activity, acting on CH-OH group of donors	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_581190_1	1380356.JNIK01000018_gene826	1.609e-62	220.0	COG2267@1|root,COG2267@2|Bacteria,2GUBM@201174|Actinobacteria,4ESVB@85013|Frankiales	201174|Actinobacteria	I	Serine aminopeptidase, S33	phaB	-	3.1.1.76	ko:K22250	-	-	-	-	ko00000,ko01000	-	-	-	Abhydrolase_1
HKD2_k127_5813258_3	479434.Sthe_0048	6.068e-88	295.0	COG1028@1|root,COG1028@2|Bacteria	479434.Sthe_0048|-	IQ	oxidoreductase activity, acting on CH-OH group of donors	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5813258_1	1128421.JAGA01000003_gene2762	6.911e-125	405.0	COG1215@1|root,COG1215@2|Bacteria,2NQUC@2323|unclassified Bacteria	2|Bacteria	M	Glycosyltransferase like family 2	rfbN	-	-	ko:K12992	ko02025,map02025	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01005	-	GT2	-	Glyco_tranf_2_3,Glycos_transf_2
HKD2_k127_5813258_0	479434.Sthe_0047	8.573e-161	519.0	COG0438@1|root,COG0438@2|Bacteria,2G5KS@200795|Chloroflexi,27Z3S@189775|Thermomicrobia	189775|Thermomicrobia	M	Glycosyl transferase 4-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
HKD2_k127_5813258_2	1382356.JQMP01000001_gene1070	7.99e-102	336.0	COG0438@1|root,COG0438@2|Bacteria,2GBD2@200795|Chloroflexi,27YUE@189775|Thermomicrobia	189775|Thermomicrobia	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5828368_0	485913.Krac_2214	8.266e-169	537.0	COG3538@1|root,COG3538@2|Bacteria	2|Bacteria	G	Metal-independent alpha-mannosidase (GH125)	-	-	-	ko:K09704	-	-	-	-	ko00000	-	-	-	Glyco_hydro_125
HKD2_k127_5828368_2	1234679.BN424_1004	1.035e-18	88.0	COG3538@1|root,COG3538@2|Bacteria,1TRJI@1239|Firmicutes,4HBQW@91061|Bacilli	91061|Bacilli	S	Glycosyl hydrolase	-	-	-	ko:K09704	-	-	-	-	ko00000	-	-	-	Glyco_hydro_125
HKD2_k127_5828368_1	485913.Krac_6017	2.909e-37	145.0	COG3039@1|root,COG3039@2|Bacteria	2|Bacteria	L	Transposase	-	-	-	ko:K07481	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DUF772
HKD2_k127_5836543_0	335541.Swol_1716	1.808e-166	554.0	COG2304@1|root,COG5426@1|root,COG2304@2|Bacteria,COG5426@2|Bacteria,1TQXZ@1239|Firmicutes,249E6@186801|Clostridia	186801|Clostridia	S	von Willebrand factor, type A	-	-	-	-	-	-	-	-	-	-	-	-	BatA,GATase1_like,VWA,VWA_2,VWA_3
HKD2_k127_5836543_2	335541.Swol_1717	2.442e-104	364.0	COG2304@1|root,COG2304@2|Bacteria,1V0C8@1239|Firmicutes,249ZD@186801|Clostridia	186801|Clostridia	S	von Willebrand factor, type A	-	-	-	-	-	-	-	-	-	-	-	-	BatA,VWA_2
HKD2_k127_5836543_3	335541.Swol_1718	1.095e-63	229.0	COG1721@1|root,COG1721@2|Bacteria,1V2UW@1239|Firmicutes,24AGA@186801|Clostridia	186801|Clostridia	S	protein some members contain a von Willebrand factor type A	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
HKD2_k127_5836543_1	1304880.JAGB01000001_gene643	3.358e-120	396.0	COG0714@1|root,COG0714@2|Bacteria,1TPKR@1239|Firmicutes,248IM@186801|Clostridia	186801|Clostridia	S	associated with various cellular activities	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
HKD2_k127_5836543_4	765420.OSCT_1965	1.593e-25	122.0	COG5022@1|root,COG5022@2|Bacteria,2GBHX@200795|Chloroflexi,37800@32061|Chloroflexia	32061|Chloroflexia	Z	LysM domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5840675_1	545697.HMPREF0216_02357	5.826e-19	102.0	COG0318@1|root,COG0318@2|Bacteria,1V2NE@1239|Firmicutes,24BX7@186801|Clostridia,36EWI@31979|Clostridiaceae	186801|Clostridia	IQ	PFAM AMP-dependent synthetase and ligase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5840675_0	485913.Krac_10559	4.174e-267	847.0	COG0827@1|root,COG1002@1|root,COG0827@2|Bacteria,COG1002@2|Bacteria,2G84A@200795|Chloroflexi	200795|Chloroflexi	LV	Pfam:Methyltransf_26	-	-	-	-	-	-	-	-	-	-	-	-	Eco57I
HKD2_k127_5845377_0	485913.Krac_8951	0.0	1763.0	COG0587@1|root,COG0587@2|Bacteria,2G5IY@200795|Chloroflexi	200795|Chloroflexi	L	TIGRFAM DNA polymerase III, alpha subunit	dnaE	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
HKD2_k127_5851514_2	485913.Krac_12539	2.12e-25	106.0	COG1959@1|root,COG1959@2|Bacteria,2G8ZH@200795|Chloroflexi	200795|Chloroflexi	K	transcriptional regulator, Rrf2 family	-	-	-	-	-	-	-	-	-	-	-	-	Rrf2
HKD2_k127_5851514_0	485913.Krac_12550	8.154e-125	406.0	COG1235@1|root,COG1235@2|Bacteria,2G833@200795|Chloroflexi	200795|Chloroflexi	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
HKD2_k127_5851514_1	485913.Krac_12549	6.556e-57	203.0	COG1994@1|root,COG1994@2|Bacteria,2G6VM@200795|Chloroflexi	200795|Chloroflexi	S	Peptidase M50	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M50
HKD2_k127_5851644_1	485913.Krac_2983	1.606e-179	572.0	COG3385@1|root,COG3385@2|Bacteria,2G7KG@200795|Chloroflexi	200795|Chloroflexi	L	PFAM transposase, IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
HKD2_k127_5851644_0	1382306.JNIM01000001_gene3374	6.616e-180	570.0	COG2133@1|root,COG2133@2|Bacteria,2G7VF@200795|Chloroflexi	200795|Chloroflexi	G	PFAM NHL repeat containing protein	-	-	-	-	-	-	-	-	-	-	-	-	GSDH
HKD2_k127_5855503_1	357808.RoseRS_2837	2.884e-38	149.0	COG2151@1|root,COG2151@2|Bacteria,2GB51@200795|Chloroflexi,377A6@32061|Chloroflexia	32061|Chloroflexia	S	Iron-sulfur cluster assembly protein	-	-	-	-	-	-	-	-	-	-	-	-	FeS_assembly_P
HKD2_k127_5855503_0	1128421.JAGA01000002_gene1009	4.81e-61	211.0	COG2159@1|root,COG2159@2|Bacteria	2|Bacteria	E	amidohydrolase	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
HKD2_k127_5864095_0	485913.Krac_8180	6.691e-222	696.0	COG0766@1|root,COG0766@2|Bacteria,2G666@200795|Chloroflexi	200795|Chloroflexi	M	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine	murA	-	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase
HKD2_k127_5864095_2	485913.Krac_8181	5.567e-213	670.0	COG1233@1|root,COG1233@2|Bacteria	2|Bacteria	Q	all-trans-retinol 13,14-reductase activity	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase,NAD_binding_8
HKD2_k127_5864095_5	391615.ABSJ01000026_gene114	1.713e-08	67.0	COG1716@1|root,COG1716@2|Bacteria,1MW1M@1224|Proteobacteria,1S50X@1236|Gammaproteobacteria,1J761@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	T	Inner membrane component of T3SS, cytoplasmic domain	-	-	-	-	-	-	-	-	-	-	-	-	FHA,Yop-YscD_cpl
HKD2_k127_5864095_6	1122228.AQXR01000009_gene1452	0.0005014	53.0	COG3087@1|root,COG3087@2|Bacteria,2IJPT@201174|Actinobacteria,4CYVI@85004|Bifidobacteriales	201174|Actinobacteria	D	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides	-	-	-	-	-	-	-	-	-	-	-	-	zinc_ribbon_2
HKD2_k127_5864095_1	485913.Krac_8183	2.052e-221	697.0	COG0593@1|root,COG0593@2|Bacteria,2G5W8@200795|Chloroflexi	200795|Chloroflexi	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids	dnaA	GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0034641,GO:0034645,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901576,GO:1990837	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA,Bac_DnaA_C,DnaA_N
HKD2_k127_5879715_0	1382306.JNIM01000001_gene1481	2.836e-67	241.0	COG0368@1|root,COG0368@2|Bacteria,2G6TU@200795|Chloroflexi	200795|Chloroflexi	H	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate	cobS	-	2.7.8.26	ko:K02233	ko00860,ko01100,map00860,map01100	M00122	R05223,R11174	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	CobS
HKD2_k127_5903543_0	485913.Krac_8124	2.558e-218	683.0	COG0542@1|root,COG0542@2|Bacteria,2G5RA@200795|Chloroflexi	2|Bacteria	O	ATPase AAA-2 domain protein	clpC	GO:0006950,GO:0008150,GO:0010035,GO:0010038,GO:0042221,GO:0046686,GO:0046688,GO:0050896,GO:0097501,GO:1990169,GO:1990170	-	ko:K03696	ko01100,map01100	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N,UVR
HKD2_k127_5911744_0	1254432.SCE1572_36820	8.269e-290	908.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,42M8F@68525|delta/epsilon subdivisions,2WIU0@28221|Deltaproteobacteria,2YXKV@29|Myxococcales	28221|Deltaproteobacteria	P	Cation transporter/ATPase, N-terminus	-	-	3.6.3.2	ko:K01531,ko:K12955	-	-	-	-	ko00000,ko01000	3.A.3.24,3.A.3.4	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
HKD2_k127_5923167_0	485913.Krac_11064	8.777e-227	711.0	COG3408@1|root,COG3408@2|Bacteria,2G8AA@200795|Chloroflexi	200795|Chloroflexi	G	Glycogen debranching enzyme N terminal	-	-	-	-	-	-	-	-	-	-	-	-	GDE_C,GDE_N
HKD2_k127_5923167_1	1382306.JNIM01000001_gene1217	1.774e-51	185.0	COG0515@1|root,COG0631@1|root,COG0515@2|Bacteria,COG0631@2|Bacteria	2|Bacteria	T	protein serine/threonine phosphatase activity	-	-	3.1.3.16	ko:K01090,ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C,PP2C_2
HKD2_k127_5929763_1	485913.Krac_8031	5.743e-59	210.0	COG1732@1|root,COG1732@2|Bacteria,2G6YB@200795|Chloroflexi	200795|Chloroflexi	M	PFAM Substrate-binding region of ABC-type glycine betaine transport system	-	-	-	ko:K05845	ko02010,map02010	M00209	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	OpuAC
HKD2_k127_5929763_0	1382306.JNIM01000001_gene608	3.016e-85	287.0	COG1174@1|root,COG1174@2|Bacteria,2G7DK@200795|Chloroflexi	200795|Chloroflexi	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K05846	ko02010,map02010	M00209	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	BPD_transp_1
HKD2_k127_5929763_2	485913.Krac_8029	2.679e-44	163.0	COG1174@1|root,COG1174@2|Bacteria,2G8XF@200795|Chloroflexi	200795|Chloroflexi	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K05846	ko02010,map02010	M00209	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	BPD_transp_1
HKD2_k127_5934042_2	485913.Krac_6415	1.681e-52	185.0	28MFE@1|root,2ZASW@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	PRiA4_ORF3
HKD2_k127_5934042_1	316274.Haur_3189	5.551e-104	346.0	COG2301@1|root,COG2301@2|Bacteria,2G6EA@200795|Chloroflexi,375UN@32061|Chloroflexia	32061|Chloroflexia	G	Belongs to the HpcH HpaI aldolase family	-	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006107,GO:0008150,GO:0008152,GO:0009987,GO:0015977,GO:0016829,GO:0016830,GO:0016833,GO:0019752,GO:0043167,GO:0043169,GO:0043427,GO:0043436,GO:0043648,GO:0044237,GO:0044281,GO:0046872,GO:0047777,GO:0050083,GO:0071704	4.1.3.24,4.1.3.25,4.1.3.34	ko:K01644,ko:K08691	ko00630,ko00660,ko00680,ko00720,ko01120,ko01200,ko02020,map00630,map00660,map00680,map00720,map01120,map01200,map02020	M00346,M00373,M00376	R00237,R00362,R00473,R00934	RC00067,RC00307,RC00308,RC00311,RC00407,RC00502,RC01118,RC01205	ko00000,ko00001,ko00002,ko01000	-	-	-	HpcH_HpaI
HKD2_k127_5934042_0	760192.Halhy_5770	4.09e-110	366.0	COG1816@1|root,COG1816@2|Bacteria,4NJ8S@976|Bacteroidetes,1IWMN@117747|Sphingobacteriia	976|Bacteroidetes	F	Adenosine/AMP deaminase	-	-	3.5.4.4	ko:K01488	ko00230,ko01100,ko05340,map00230,map01100,map05340	-	R01560,R02556	RC00477	ko00000,ko00001,ko01000	-	-	-	A_deaminase
HKD2_k127_5934254_0	485913.Krac_6726	0.0	1123.0	COG2183@1|root,COG2183@2|Bacteria,2G66S@200795|Chloroflexi	200795|Chloroflexi	K	Tex-like protein N-terminal domain	-	-	-	ko:K06959	-	-	-	-	ko00000	-	-	-	HHH_3,S1,Tex_N,Tex_YqgF
HKD2_k127_5934254_1	485913.Krac_6731	1.502e-28	120.0	COG0515@1|root,COG0515@2|Bacteria	485913.Krac_6731|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5934724_1	1382306.JNIM01000001_gene1964	2.388e-83	280.0	COG0520@1|root,COG0520@2|Bacteria	2|Bacteria	E	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine	ycbU	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
HKD2_k127_5934724_0	1382306.JNIM01000001_gene1965	7.912e-158	507.0	COG1104@1|root,COG1104@2|Bacteria	2|Bacteria	E	Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins	iscS	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
HKD2_k127_5945114_2	485913.Krac_11737	2.911e-25	106.0	COG1335@1|root,COG1335@2|Bacteria,2G6JY@200795|Chloroflexi	200795|Chloroflexi	Q	Isochorismatase family	-	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
HKD2_k127_5945114_0	1382306.JNIM01000001_gene528	2.907e-87	293.0	COG1011@1|root,COG1011@2|Bacteria,2G78N@200795|Chloroflexi	200795|Chloroflexi	S	PFAM Haloacid dehalogenase domain protein hydrolase	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2
HKD2_k127_5961667_0	485913.Krac_7762	1.894e-175	556.0	COG0399@1|root,COG0399@2|Bacteria,2G7J4@200795|Chloroflexi	200795|Chloroflexi	E	Belongs to the DegT DnrJ EryC1 family	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
HKD2_k127_5961667_1	485913.Krac_7761	8.743e-170	537.0	COG0673@1|root,COG0673@2|Bacteria,2G6PI@200795|Chloroflexi	200795|Chloroflexi	S	PFAM oxidoreductase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
HKD2_k127_5961667_2	880073.Calab_2000	6.952e-108	359.0	COG0451@1|root,COG0451@2|Bacteria,2NNNX@2323|unclassified Bacteria	2|Bacteria	GM	NAD(P)H-binding	wbpP	-	5.1.3.2,5.1.3.7	ko:K01784,ko:K02473	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R00418,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
HKD2_k127_5961667_3	1123024.AUII01000022_gene95	3.599e-70	248.0	COG0438@1|root,COG0438@2|Bacteria,2GSQI@201174|Actinobacteria,4E1TK@85010|Pseudonocardiales	201174|Actinobacteria	M	Glycosyl transferase 4-like	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4
HKD2_k127_597792_2	1254432.SCE1572_37555	5.101e-56	214.0	COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,42N87@68525|delta/epsilon subdivisions,2WV45@28221|Deltaproteobacteria,2YZDV@29|Myxococcales	28221|Deltaproteobacteria	S	ABC1 family	-	-	-	-	-	-	-	-	-	-	-	-	ABC1
HKD2_k127_597792_1	485913.Krac_6158	1.083e-83	288.0	COG2319@1|root,COG2319@2|Bacteria	2|Bacteria	S	anaphase-promoting complex binding	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos,NACHT,PD40,Pentapeptide,Pkinase,TIR_2,WD40
HKD2_k127_597792_0	1382306.JNIM01000001_gene1213	5.224e-224	705.0	COG0318@1|root,COG0318@2|Bacteria,2G5Q8@200795|Chloroflexi	200795|Chloroflexi	IQ	PFAM AMP-dependent synthetase and ligase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
HKD2_k127_5980341_0	1382306.JNIM01000001_gene410	1.536e-86	289.0	COG0463@1|root,COG0463@2|Bacteria,2G6TA@200795|Chloroflexi	200795|Chloroflexi	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HKD2_k127_5980341_1	485913.Krac_8969	4.085e-79	275.0	COG5305@1|root,COG5305@2|Bacteria,2G7EE@200795|Chloroflexi	200795|Chloroflexi	S	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HKD2_k127_5986809_1	485913.Krac_7843	9.287e-207	647.0	COG0482@1|root,COG0482@2|Bacteria,2G64I@200795|Chloroflexi	200795|Chloroflexi	J	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34	mnmA	-	2.8.1.13	ko:K00566	ko04122,map04122	-	R08700	RC02313,RC02315	ko00000,ko00001,ko01000,ko03016	-	-	-	tRNA_Me_trans
HKD2_k127_5986809_0	1382306.JNIM01000001_gene1307	1e-323	997.0	COG0481@1|root,COG0481@2|Bacteria,2G5K2@200795|Chloroflexi	200795|Chloroflexi	J	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner	lepA	-	-	ko:K03596	ko05134,map05134	-	-	-	ko00000,ko00001	-	-	-	EFG_C,EFG_II,GTP_EFTU,GTP_EFTU_D2,LepA_C
HKD2_k127_5986809_2	485913.Krac_7840	1.592e-84	285.0	COG5637@1|root,COG5637@2|Bacteria,2G9EF@200795|Chloroflexi	200795|Chloroflexi	S	PFAM Polyketide cyclase dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc,Polyketide_cyc2
HKD2_k127_5986809_3	927658.AJUM01000047_gene2931	1.295e-66	235.0	COG0042@1|root,COG0042@2|Bacteria,4NEMR@976|Bacteroidetes,2FRWE@200643|Bacteroidia,3XJHB@558415|Marinilabiliaceae	976|Bacteroidetes	J	Dihydrouridine synthase (Dus)	-	-	-	-	-	-	-	-	-	-	-	-	Dus
HKD2_k127_5993797_0	485913.Krac_12194	4.532e-60	211.0	COG3842@1|root,COG3842@2|Bacteria,2G5X9@200795|Chloroflexi	200795|Chloroflexi	P	PFAM ABC transporter related	-	-	-	ko:K10112	ko02010,map02010	M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1	-	-	ABC_tran,TOBE,TOBE_2
HKD2_k127_5993797_1	485913.Krac_3921	3.002e-56	207.0	COG0726@1|root,COG0726@2|Bacteria,2G76U@200795|Chloroflexi	200795|Chloroflexi	G	polysaccharide deacetylase	-	-	3.5.1.104	ko:K22278	-	-	-	-	ko00000,ko01000	-	-	-	Glycos_transf_2,Polysacc_deac_1
HKD2_k127_5994462_0	485913.Krac_12110	7.646e-239	745.0	COG0457@1|root,COG0457@2|Bacteria	485913.Krac_12110|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5994462_1	485913.Krac_12111	3.408e-202	641.0	COG1022@1|root,COG1022@2|Bacteria,2G5S9@200795|Chloroflexi	200795|Chloroflexi	I	PFAM AMP-dependent synthetase and ligase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
HKD2_k127_6031254_3	485913.Krac_10501	6.99e-14	71.0	COG2096@1|root,COG2096@2|Bacteria,2G6TB@200795|Chloroflexi	200795|Chloroflexi	S	PFAM Cobalamin adenosyltransferase	-	-	2.5.1.17	ko:K00798	ko00860,ko01100,map00860,map01100	M00122	R01492,R05220,R07268	RC00533	ko00000,ko00001,ko00002,ko01000	-	-	-	Cob_adeno_trans
HKD2_k127_6031254_1	485913.Krac_10485	6.377e-93	311.0	COG1387@1|root,COG1387@2|Bacteria	2|Bacteria	E	zinc ion binding	hisJ	-	3.1.3.15	ko:K04486	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R03013	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PHP
HKD2_k127_6031254_2	485913.Krac_10484	7.452e-86	289.0	COG4122@1|root,COG4122@2|Bacteria,2G8S5@200795|Chloroflexi	200795|Chloroflexi	S	PFAM O-methyltransferase, family 3	-	-	2.1.1.104	ko:K00588	ko00360,ko00940,ko00941,ko00945,ko01100,ko01110,map00360,map00940,map00941,map00945,map01100,map01110	M00039,M00350	R01942,R06578	RC00003,RC00392	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_3
HKD2_k127_6031254_0	485913.Krac_10483	1.913e-140	463.0	COG0457@1|root,COG3629@1|root,COG3899@1|root,COG0457@2|Bacteria,COG3629@2|Bacteria,COG3899@2|Bacteria,2G871@200795|Chloroflexi	200795|Chloroflexi	K	Transcriptional activator domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,BTAD,TPR_12
HKD2_k127_6050178_2	485913.Krac_12460	4.682e-41	154.0	COG0023@1|root,COG0023@2|Bacteria,2G9JW@200795|Chloroflexi	200795|Chloroflexi	J	Translation initiation factor SUI1	-	-	-	ko:K03113	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	SUI1
HKD2_k127_6050178_0	485913.Krac_12461	1.469e-130	427.0	COG2355@1|root,COG2355@2|Bacteria,2G6FQ@200795|Chloroflexi	200795|Chloroflexi	E	Membrane dipeptidase (Peptidase family M19)	-	-	3.4.13.19	ko:K01273	-	-	-	-	ko00000,ko00537,ko01000,ko01002,ko04147	-	-	-	Peptidase_M19
HKD2_k127_6050178_1	485913.Krac_12462	2.023e-91	311.0	COG0515@1|root,COG0515@2|Bacteria,2G67H@200795|Chloroflexi	485913.Krac_12462|-	KLT	SMART serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6065091_3	485913.Krac_8337	6.603e-68	238.0	COG0286@1|root,COG0286@2|Bacteria	2|Bacteria	V	site-specific DNA-methyltransferase (adenine-specific) activity	-	-	2.1.1.72	ko:K03427	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	Methylase_S,N6_Mtase
HKD2_k127_6065091_2	1382306.JNIM01000001_gene377	1.836e-75	255.0	COG2185@1|root,COG2185@2|Bacteria,2G6S9@200795|Chloroflexi	200795|Chloroflexi	I	PFAM cobalamin B12-binding domain protein	-	-	5.4.99.2	ko:K01849	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding
HKD2_k127_6065091_1	485913.Krac_8335	1.57e-153	490.0	COG1703@1|root,COG1703@2|Bacteria,2G670@200795|Chloroflexi	200795|Chloroflexi	E	TIGRFAM LAO AO transport system ATPase	-	-	-	ko:K07588	-	-	-	-	ko00000,ko01000	-	-	-	ArgK
HKD2_k127_6065091_0	485913.Krac_8334	5.391e-222	696.0	COG1061@1|root,COG1061@2|Bacteria,2G7QW@200795|Chloroflexi	200795|Chloroflexi	L	Type III restriction protein res subunit	-	-	-	-	-	-	-	-	-	-	-	-	ERCC3_RAD25_C,ResIII
HKD2_k127_6070483_2	383372.Rcas_3731	1.709e-24	107.0	COG0757@1|root,COG0757@2|Bacteria,2G6N1@200795|Chloroflexi,3775Y@32061|Chloroflexia	32061|Chloroflexia	E	Catalyzes a trans-dehydration via an enolate intermediate	aroQ	-	4.2.1.10	ko:K03786	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03084	RC00848	ko00000,ko00001,ko00002,ko01000	-	-	-	DHquinase_II
HKD2_k127_6070483_1	485913.Krac_5033	4.737e-115	377.0	COG0842@1|root,COG0842@2|Bacteria,2G7XT@200795|Chloroflexi	200795|Chloroflexi	V	ABC-2 family transporter protein	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane
HKD2_k127_6070483_0	485913.Krac_5034	3.142e-129	416.0	COG1131@1|root,COG1131@2|Bacteria	2|Bacteria	V	ATPase activity	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD2_k127_6074210_2	1382306.JNIM01000001_gene915	7.549e-126	409.0	COG0777@1|root,COG0777@2|Bacteria,2G6E1@200795|Chloroflexi	200795|Chloroflexi	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA	accD	-	2.1.3.15,6.4.1.2	ko:K01963	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
HKD2_k127_6074210_0	485913.Krac_6879	2.388e-160	510.0	COG0552@1|root,COG0552@2|Bacteria,2G63M@200795|Chloroflexi	200795|Chloroflexi	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)	ftsY	-	-	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2,3.A.5.7	-	-	SRP54,SRP54_N
HKD2_k127_6074210_4	485913.Krac_6878	1.48e-39	148.0	2EQ8R@1|root,33HV0@2|Bacteria,2G91J@200795|Chloroflexi	200795|Chloroflexi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6074210_1	485913.Krac_6861	5.818e-155	499.0	COG0568@1|root,COG0568@2|Bacteria,2G5W3@200795|Chloroflexi	200795|Chloroflexi	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	-	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
HKD2_k127_6074210_5	485913.Krac_8466	1.133e-35	139.0	COG1550@1|root,COG1550@2|Bacteria,2G765@200795|Chloroflexi	200795|Chloroflexi	S	Protein of unknown function (DUF503)	-	-	-	ko:K09764	-	-	-	-	ko00000	-	-	-	DUF503
HKD2_k127_6074210_3	485913.Krac_8465	1.308e-75	260.0	COG1922@1|root,COG1922@2|Bacteria,2G6J0@200795|Chloroflexi	200795|Chloroflexi	M	Belongs to the glycosyltransferase 26 family	-	-	2.4.1.187	ko:K05946	ko05111,map05111	-	-	-	ko00000,ko00001,ko01000,ko01003	-	GT26	-	Glyco_tran_WecB
HKD2_k127_6088056_3	485913.Krac_9699	4.119e-48	175.0	COG3415@1|root,COG3415@2|Bacteria	2|Bacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_ISAZ013,HTH_Tnp_4
HKD2_k127_6088056_1	485913.Krac_10873	1.368e-66	232.0	COG3871@1|root,COG3871@2|Bacteria,2G98H@200795|Chloroflexi	200795|Chloroflexi	S	PFAM pyridoxamine 5'-phosphate oxidase-related, FMN-binding	-	-	-	-	-	-	-	-	-	-	-	-	Pyrid_ox_like
HKD2_k127_6088056_0	485913.Krac_2600	1.102e-130	426.0	COG2038@1|root,COG2038@2|Bacteria,2G5R3@200795|Chloroflexi	200795|Chloroflexi	F	Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB)	cobT	-	2.4.2.21	ko:K00768	ko00860,ko01100,map00860,map01100	M00122	R04148	RC00033,RC00063	ko00000,ko00001,ko00002,ko01000	-	-	-	DBI_PRT
HKD2_k127_6088056_2	485913.Krac_2077	1.205e-48	175.0	COG0614@1|root,COG0614@2|Bacteria,2G6TS@200795|Chloroflexi	200795|Chloroflexi	P	periplasmic binding protein	-	-	-	ko:K02016	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	Peripla_BP_2
HKD2_k127_6088850_1	1382306.JNIM01000001_gene1160	6.909e-36	137.0	COG0260@1|root,COG0260@2|Bacteria,2G617@200795|Chloroflexi	200795|Chloroflexi	E	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	pepA	-	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17,Peptidase_M17_N
HKD2_k127_6088850_0	485913.Krac_2641	2.525e-187	596.0	COG1233@1|root,COG1233@2|Bacteria,2G60T@200795|Chloroflexi	200795|Chloroflexi	Q	NAD(P)-binding Rossmann-like domain	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_8
HKD2_k127_6088850_2	765952.PUV_08150	1.163e-07	55.0	COG1233@1|root,COG1233@2|Bacteria	2|Bacteria	Q	all-trans-retinol 13,14-reductase activity	pys	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase,NAD_binding_8
HKD2_k127_6089090_1	485913.Krac_8964	1.162e-59	209.0	COG0853@1|root,COG0853@2|Bacteria,2G6Z6@200795|Chloroflexi	200795|Chloroflexi	H	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine	panD	-	4.1.1.11	ko:K01579	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R00489	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Asp_decarbox
HKD2_k127_6089090_2	1382306.JNIM01000001_gene4098	1.003e-57	203.0	COG2337@1|root,COG2337@2|Bacteria,2G9EZ@200795|Chloroflexi	200795|Chloroflexi	L	PemK-like, MazF-like toxin of type II toxin-antitoxin system	-	-	-	ko:K07171	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PemK_toxin
HKD2_k127_6108359_2	485913.Krac_9943	2.535e-129	417.0	COG0115@1|root,COG0115@2|Bacteria,2G8EE@200795|Chloroflexi	200795|Chloroflexi	EH	Amino-transferase class IV	-	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
HKD2_k127_6108359_3	485913.Krac_1305	7.302e-28	116.0	COG1308@1|root,COG1308@2|Bacteria	2|Bacteria	K	protein transport	-	-	-	-	-	-	-	-	-	-	-	-	DUF4342
HKD2_k127_6108359_4	1444309.JAQG01000004_gene3592	3.336e-24	108.0	COG2318@1|root,COG2318@2|Bacteria,1VW3T@1239|Firmicutes,4HWQI@91061|Bacilli,26Y17@186822|Paenibacillaceae	91061|Bacilli	S	DinB superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
HKD2_k127_6108359_0	485913.Krac_1306	0.0	1184.0	COG0188@1|root,COG0188@2|Bacteria,2G82T@200795|Chloroflexi	200795|Chloroflexi	L	DNA Topoisomerase IV	-	-	-	-	-	-	-	-	-	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
HKD2_k127_6108359_1	485913.Krac_1308	0.0	1167.0	COG0187@1|root,COG0187@2|Bacteria,2G7RD@200795|Chloroflexi	200795|Chloroflexi	L	TopoisomeraseII	-	-	-	-	-	-	-	-	-	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
HKD2_k127_6120929_0	485913.Krac_8285	1.599e-82	291.0	COG0515@1|root,COG0515@2|Bacteria	485913.Krac_8285|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6120929_1	65093.PCC7418_0705	5.768e-50	178.0	COG1225@1|root,COG1225@2|Bacteria,1G0JC@1117|Cyanobacteria	1117|Cyanobacteria	O	Alkyl hydroperoxide reductase and or thiol-specific antioxidant family (AhpC TSA) protein	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
HKD2_k127_6128190_0	485913.Krac_11338	1.738e-54	192.0	COG4608@1|root,COG4608@2|Bacteria,2G5R5@200795|Chloroflexi	2|Bacteria	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
HKD2_k127_6128190_1	485913.Krac_7869	1.569e-46	172.0	COG4243@1|root,COG4243@2|Bacteria	2|Bacteria	S	quinone binding	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_4,VKOR
HKD2_k127_6128190_2	485913.Krac_7867	1.538e-19	89.0	COG0842@1|root,COG0842@2|Bacteria,2G8GV@200795|Chloroflexi	200795|Chloroflexi	V	Transport permease protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
HKD2_k127_6132272_2	1173027.Mic7113_1776	3.245e-37	143.0	COG1028@1|root,COG1028@2|Bacteria,1G1XA@1117|Cyanobacteria,1H9B1@1150|Oscillatoriales	1117|Cyanobacteria	IQ	PFAM short chain dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HKD2_k127_6132272_0	485913.Krac_0465	3.749e-67	233.0	COG1853@1|root,COG1853@2|Bacteria	2|Bacteria	S	FMN binding	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
HKD2_k127_6145397_1	485913.Krac_3162	4.841e-36	140.0	COG1073@1|root,COG1073@2|Bacteria,2G8PF@200795|Chloroflexi	200795|Chloroflexi	S	X-Pro dipeptidyl-peptidase (S15 family)	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4
HKD2_k127_6145397_2	543728.Vapar_4986	2.241e-27	125.0	COG0707@1|root,COG0707@2|Bacteria,1QU89@1224|Proteobacteria,2VKVF@28216|Betaproteobacteria,4AFFZ@80864|Comamonadaceae	28216|Betaproteobacteria	M	Monogalactosyldiacylglycerol (MGDG) synthase	-	-	2.4.1.315,2.4.1.46	ko:K03429,ko:K03715	ko00561,ko01100,map00561,map01100	-	R02689,R02691,R04377	RC00005,RC00059	ko00000,ko00001,ko01000,ko01003	-	GT28	-	Glyco_tran_28_C,MGDG_synth
HKD2_k127_6145397_0	485913.Krac_6976	1.157e-50	181.0	COG0675@1|root,COG0675@2|Bacteria,2G89V@200795|Chloroflexi	200795|Chloroflexi	L	TIGRFAM transposase, IS605 OrfB family	-	-	-	ko:K07496	-	-	-	-	ko00000	-	-	-	HTH_OrfB_IS605,OrfB_IS605,OrfB_Zn_ribbon
HKD2_k127_6151111_2	485913.Krac_2323	7.712e-71	245.0	COG0586@1|root,COG0586@2|Bacteria	2|Bacteria	S	FtsZ-dependent cytokinesis	yabI	GO:0000003,GO:0000910,GO:0005575,GO:0005623,GO:0005886,GO:0007049,GO:0008150,GO:0009314,GO:0009628,GO:0009987,GO:0010212,GO:0016020,GO:0019954,GO:0022402,GO:0022414,GO:0032505,GO:0043093,GO:0044464,GO:0050896,GO:0051301,GO:0071944	3.6.1.27	ko:K03975,ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	LssY_C,PAP2,SNARE_assoc
HKD2_k127_6151111_1	485913.Krac_0782	5.491e-124	408.0	COG0265@1|root,COG0265@2|Bacteria,2G6KV@200795|Chloroflexi	200795|Chloroflexi	O	PFAM peptidase S1 and S6, chymotrypsin Hap	-	-	1.3.1.74	ko:K08070	-	-	-	-	ko00000,ko01000	-	-	-	PDZ_2,Trypsin_2
HKD2_k127_6151111_0	485913.Krac_1174	5.173e-140	451.0	COG0861@1|root,COG0861@2|Bacteria,2G66P@200795|Chloroflexi	200795|Chloroflexi	P	PFAM Integral membrane protein TerC	-	-	-	ko:K05794	-	-	-	-	ko00000	-	-	-	TerC
HKD2_k127_6151111_3	383372.Rcas_1230	9.777e-64	224.0	COG0265@1|root,COG0265@2|Bacteria,2G6I9@200795|Chloroflexi,376AN@32061|Chloroflexia	32061|Chloroflexia	O	PFAM peptidase S1 and S6, chymotrypsin Hap	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
HKD2_k127_6161520_0	706587.Desti_4690	4.576e-32	129.0	2FB1H@1|root,34387@2|Bacteria,1P1MI@1224|Proteobacteria,4317E@68525|delta/epsilon subdivisions,2WW7J@28221|Deltaproteobacteria,2MS7T@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	PFAM coenzyme PQQ synthesis	-	-	-	-	-	-	-	-	-	-	-	-	PqqD
HKD2_k127_6169068_0	485913.Krac_12240	6.353e-200	627.0	COG0322@1|root,COG0322@2|Bacteria,2G651@200795|Chloroflexi	200795|Chloroflexi	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	-	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N
HKD2_k127_6170860_3	485913.Krac_4964	2.453e-06	53.0	COG3464@1|root,COG3464@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_ISL3,HTH_Tnp_ISL3,zf-ISL3
HKD2_k127_6170860_2	485913.Krac_8886	1.36e-17	84.0	COG2608@1|root,COG2608@2|Bacteria	2|Bacteria	P	mercury ion transmembrane transporter activity	-	-	-	ko:K07213,ko:K08364	ko04978,map04978	-	-	-	ko00000,ko00001,ko02000	1.A.72.1	-	-	HMA
HKD2_k127_6170860_4	485913.Krac_5467	0.0001073	46.0	COG2211@1|root,COG2211@2|Bacteria,2G73C@200795|Chloroflexi	2|Bacteria	G	PFAM major facilitator superfamily MFS_1	yqjV	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_1_like
HKD2_k127_6170860_0	485913.Krac_2195	6.464e-110	368.0	COG2146@1|root,COG2146@2|Bacteria	2|Bacteria	P	nitrite reductase [NAD(P)H] activity	-	-	1.8.5.2	ko:K16937	ko00920,ko01120,map00920,map01120	-	R07177	-	ko00000,ko00001,ko01000	3.D.4.9	-	-	DoxX,Rieske
HKD2_k127_6170860_1	485913.Krac_5058	4.95e-80	274.0	COG5002@1|root,COG5002@2|Bacteria,2G68T@200795|Chloroflexi	200795|Chloroflexi	T	histidine kinase HAMP region domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
HKD2_k127_6191764_0	485913.Krac_11316	1.801e-137	441.0	COG0077@1|root,COG0077@2|Bacteria,2G6AP@200795|Chloroflexi	200795|Chloroflexi	E	amino acid-binding ACT domain protein	pheA	-	4.2.1.51	ko:K04518	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024	R00691,R01373	RC00360	ko00000,ko00001,ko00002,ko01000	-	-	-	PDT
HKD2_k127_6191764_1	1304284.L21TH_1158	3.361e-114	383.0	COG1523@1|root,COG1523@2|Bacteria,1TP3M@1239|Firmicutes,2481P@186801|Clostridia,36E5I@31979|Clostridiaceae	186801|Clostridia	G	Belongs to the glycosyl hydrolase 13 family	pulA	-	3.2.1.41	ko:K01200	ko00500,ko01100,ko01110,map00500,map01100,map01110	-	R02111	-	ko00000,ko00001,ko01000	-	CBM48,GH13	-	Alpha-amylase,Big_2,CBM_48,DUF3372,PUD
HKD2_k127_6193095_0	1382306.JNIM01000001_gene4195	1.815e-64	229.0	COG0204@1|root,COG2324@1|root,COG0204@2|Bacteria,COG2324@2|Bacteria	2|Bacteria	S	Carotenoid biosynthesis protein	cruF	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase,Caroten_synth
HKD2_k127_6193095_1	485913.Krac_3463	3.896e-21	93.0	COG1215@1|root,COG1215@2|Bacteria,2G6RJ@200795|Chloroflexi	200795|Chloroflexi	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3
HKD2_k127_6203632_0	485913.Krac_7992	3.742e-300	928.0	COG2936@1|root,COG2936@2|Bacteria,2G85Q@200795|Chloroflexi	200795|Chloroflexi	S	PFAM X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	PepX_C,Peptidase_S15
HKD2_k127_6203632_2	1382306.JNIM01000001_gene1107	3.429e-91	305.0	COG1716@1|root,COG1716@2|Bacteria	2|Bacteria	T	histone H2A K63-linked ubiquitination	-	-	-	ko:K21832	-	-	-	-	ko00000	-	-	-	FAD_binding_6,FHA,Fer2,NAD_binding_1,SLT
HKD2_k127_6208392_0	485913.Krac_11739	0.0	1179.0	COG0515@1|root,COG1199@1|root,COG0515@2|Bacteria,COG1199@2|Bacteria,2G88S@200795|Chloroflexi	200795|Chloroflexi	KLT	HELICc2	-	-	3.6.4.12	ko:K03722	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD_2,Helicase_C_2,Pkinase
HKD2_k127_6229291_1	485913.Krac_8720	1.267e-27	113.0	COG0789@1|root,COG0789@2|Bacteria,2G9H2@200795|Chloroflexi	200795|Chloroflexi	L	DNA binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_17
HKD2_k127_6229291_0	1444309.JAQG01000015_gene1621	4.473e-120	396.0	COG0372@1|root,COG0372@2|Bacteria,1TPPS@1239|Firmicutes,4HDG0@91061|Bacilli,26TNW@186822|Paenibacillaceae	91061|Bacilli	C	Belongs to the citrate synthase family	citA	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
HKD2_k127_6239781_1	485913.Krac_8639	1.37e-63	225.0	COG1999@1|root,COG1999@2|Bacteria,2G6UW@200795|Chloroflexi	200795|Chloroflexi	S	Electron transport protein SCO1 SenC	-	-	-	ko:K07152	-	-	-	-	ko00000,ko03029	-	-	-	SCO1-SenC
HKD2_k127_6239781_0	1382306.JNIM01000001_gene4039	5.836e-239	753.0	COG0109@1|root,COG1612@1|root,COG0109@2|Bacteria,COG1612@2|Bacteria,2G5UC@200795|Chloroflexi	200795|Chloroflexi	H	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group	ctaB	GO:0003674,GO:0003824,GO:0004311,GO:0004659,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0015980,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0045333,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.141	ko:K02257	ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714	M00154	R07411	RC01786	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029	-	-	-	COX15-CtaA,UbiA
HKD2_k127_6246121_0	383372.Rcas_4227	8.918e-51	188.0	COG2197@1|root,COG2197@2|Bacteria,2G6T1@200795|Chloroflexi,376HK@32061|Chloroflexia	32061|Chloroflexia	K	Two component transcriptional regulator, LuxR family	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HKD2_k127_6246121_1	1382306.JNIM01000001_gene4068	1.113e-45	168.0	COG0745@1|root,COG0745@2|Bacteria	1382306.JNIM01000001_gene4068|-	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6246121_3	485913.Krac_12371	2.922e-23	100.0	COG0697@1|root,COG0697@2|Bacteria	2|Bacteria	EG	spore germination	yedA	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0016020,GO:0022857,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944	-	-	-	-	-	-	-	-	-	-	EamA
HKD2_k127_6254955_0	485913.Krac_11247	1.319e-303	944.0	COG0532@1|root,COG0532@2|Bacteria,2G5UR@200795|Chloroflexi	200795|Chloroflexi	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,IF-2,IF2_N
HKD2_k127_6254955_5	485913.Krac_11248	2.372e-49	182.0	COG0858@1|root,COG0858@2|Bacteria,2G73E@200795|Chloroflexi	200795|Chloroflexi	J	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA	rbfA	-	-	ko:K02834	-	-	-	-	ko00000,ko03009	-	-	-	RBFA
HKD2_k127_6254955_1	485913.Krac_11249	1.626e-132	431.0	COG0618@1|root,COG0618@2|Bacteria,2G6RF@200795|Chloroflexi	200795|Chloroflexi	S	PFAM phosphoesterase, RecJ domain protein	-	-	3.1.13.3,3.1.3.7	ko:K06881	ko00920,ko01100,ko01120,map00920,map01100,map01120	-	R00188,R00508	RC00078	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
HKD2_k127_6254955_3	485913.Krac_11250	1.091e-114	377.0	COG0130@1|root,COG0130@2|Bacteria,2G6F4@200795|Chloroflexi	200795|Chloroflexi	J	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs	truB	-	5.4.99.25	ko:K03177	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruB-C_2,TruB_C,TruB_C_2,TruB_N
HKD2_k127_6254955_2	485913.Krac_11251	1.407e-123	404.0	COG0196@1|root,COG0196@2|Bacteria,2G6JF@200795|Chloroflexi	200795|Chloroflexi	H	Belongs to the ribF family	ribF	-	2.7.1.26,2.7.7.2	ko:K11753	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00161,R00549	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_syn,Flavokinase
HKD2_k127_6254955_4	485913.Krac_11252	1.663e-57	203.0	COG1716@1|root,COG1716@2|Bacteria,2G79K@200795|Chloroflexi	200795|Chloroflexi	T	PFAM Forkhead-associated protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF3662,FHA
HKD2_k127_6260002_0	485913.Krac_8257	6.12e-87	295.0	COG0705@1|root,COG0705@2|Bacteria	2|Bacteria	S	proteolysis	-	-	3.4.21.105	ko:K19225	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Rhomboid
HKD2_k127_6260002_1	485913.Krac_11590	4.733e-78	266.0	COG0705@1|root,COG0705@2|Bacteria	2|Bacteria	S	proteolysis	-	-	3.4.21.105	ko:K19225	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Rhomboid
HKD2_k127_6262552_3	1382306.JNIM01000001_gene2992	9.129e-121	395.0	COG0414@1|root,COG0414@2|Bacteria,2G64N@200795|Chloroflexi	200795|Chloroflexi	H	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate	panC	GO:0003674,GO:0003824,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006573,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605	6.3.2.1	ko:K01918	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R02473	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_ligase
HKD2_k127_6262552_2	1382306.JNIM01000001_gene2991	8.286e-122	397.0	COG0413@1|root,COG0413@2|Bacteria,2G5TQ@200795|Chloroflexi	200795|Chloroflexi	H	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate	panB	-	2.1.2.11	ko:K00606	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R01226	RC00022,RC00200	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_transf
HKD2_k127_6262552_0	1382306.JNIM01000001_gene1243	9.835e-173	546.0	COG0059@1|root,COG0059@2|Bacteria,2G5NP@200795|Chloroflexi	200795|Chloroflexi	H	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate	ilvC	-	1.1.1.86	ko:K00053	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R03051,R04439,R04440,R05068,R05069,R05071	RC00726,RC00836,RC00837,RC01726	ko00000,ko00001,ko00002,ko01000	-	-	-	IlvC,IlvN
HKD2_k127_6262552_1	485913.Krac_1157	8.753e-146	474.0	COG0520@1|root,COG0520@2|Bacteria,2G7JU@200795|Chloroflexi	200795|Chloroflexi	E	Cys/Met metabolism PLP-dependent enzyme	-	-	-	ko:K11325	-	-	-	-	ko00000	-	-	-	Aminotran_5
HKD2_k127_6262552_4	485913.Krac_2862	8.557e-16	78.0	COG1226@1|root,COG1226@2|Bacteria,2G7EI@200795|Chloroflexi	200795|Chloroflexi	P	PFAM TrkA-N domain protein	-	-	-	-	-	-	-	-	-	-	-	-	TrkA_C,TrkA_N
HKD2_k127_6267556_0	485913.Krac_11939	8.48e-86	293.0	COG1191@1|root,COG1191@2|Bacteria,2G8JZ@200795|Chloroflexi	200795|Chloroflexi	K	TIGRFAM RNA polymerase sigma factor, FliA WhiG family	-	-	-	ko:K02405	ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111	-	-	-	ko00000,ko00001,ko02035,ko03021	-	-	-	Sigma70_r2,Sigma70_r3,Sigma70_r4
HKD2_k127_6267556_1	1128421.JAGA01000004_gene2571	3.789e-39	147.0	COG1502@1|root,COG1502@2|Bacteria,2NP9D@2323|unclassified Bacteria	2|Bacteria	I	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol	cls-1	-	-	ko:K06131	ko00564,ko01100,map00564,map01100	-	R07390	RC00017	ko00000,ko00001,ko01000	-	-	iAF987.Gmet_3078	PLDc_2
HKD2_k127_6268762_0	485913.Krac_2317	2.253e-121	399.0	COG4988@1|root,COG4988@2|Bacteria,2G7JB@200795|Chloroflexi	200795|Chloroflexi	CO	ABC transporter CydDC cysteine exporter (CydDC-E) family permease ATP-binding protein CydD	-	-	-	ko:K16013	ko02010,map02010	-	-	-	ko00000,ko00001,ko02000	3.A.1.129	-	-	ABC_membrane,ABC_tran
HKD2_k127_6269862_0	485913.Krac_6742	2.566e-240	755.0	COG0472@1|root,COG0472@2|Bacteria,2G5TJ@200795|Chloroflexi	200795|Chloroflexi	M	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan	mraY	-	2.7.8.13	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	-	R05629,R05630	RC00002,RC02753	ko00000,ko00001,ko01000,ko01011	9.B.146	-	-	Glycos_transf_4,MraY_sig1
HKD2_k127_6269862_3	56107.Cylst_2107	6.793e-40	149.0	COG0698@1|root,COG0698@2|Bacteria,1G9WT@1117|Cyanobacteria,1HS96@1161|Nostocales	1117|Cyanobacteria	G	TIGRFAM sugar-phosphate isomerases, RpiB LacA LacB family	rpiB	-	5.3.1.6	ko:K01808	ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01056,R09030	RC00376,RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	LacAB_rpiB
HKD2_k127_6269862_4	63737.Npun_F4016	2.673e-17	85.0	COG0698@1|root,COG0698@2|Bacteria,1G9WT@1117|Cyanobacteria,1HS96@1161|Nostocales	1117|Cyanobacteria	G	TIGRFAM sugar-phosphate isomerases, RpiB LacA LacB family	rpiB	-	5.3.1.6	ko:K01808	ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01056,R09030	RC00376,RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	LacAB_rpiB
HKD2_k127_6269862_1	485913.Krac_9342	6.156e-162	517.0	COG1063@1|root,COG1063@2|Bacteria,2G6PM@200795|Chloroflexi	200795|Chloroflexi	E	Alcohol dehydrogenase GroES-like domain	-	-	1.1.1.14	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014	R00875,R01896	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
HKD2_k127_6269862_2	1382306.JNIM01000001_gene2504	4.757e-49	179.0	COG1917@1|root,COG1917@2|Bacteria	2|Bacteria	L	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HKD2_k127_6275665_0	485913.Krac_7771	1.165e-188	599.0	COG0337@1|root,COG0337@2|Bacteria,2G5K8@200795|Chloroflexi	200795|Chloroflexi	E	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)	aroB	-	2.7.1.71,4.2.3.4	ko:K01735,ko:K13829	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412,R03083	RC00002,RC00078,RC00847	ko00000,ko00001,ko00002,ko01000	-	-	-	DHQ_synthase,SKI
HKD2_k127_6277814_1	1382306.JNIM01000001_gene4106	2.899e-10	61.0	COG2348@1|root,COG2348@2|Bacteria,2G6KK@200795|Chloroflexi	200795|Chloroflexi	V	PFAM Methicillin resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	FemAB
HKD2_k127_6277814_0	1382306.JNIM01000001_gene4107	2.08e-182	578.0	COG2348@1|root,COG2348@2|Bacteria,2G6KK@200795|Chloroflexi	200795|Chloroflexi	V	PFAM Methicillin resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	FemAB
HKD2_k127_6277814_2	485913.Krac_10392	8.066e-07	51.0	COG3415@1|root,COG3415@2|Bacteria	2|Bacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	HTH_23,HTH_28,HTH_32,HTH_33
HKD2_k127_6285144_1	485913.Krac_7973	1.172e-98	327.0	COG1215@1|root,COG1215@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HKD2_k127_6285144_2	485913.Krac_7974	9.887e-73	252.0	COG3222@1|root,COG3222@2|Bacteria,2G988@200795|Chloroflexi	200795|Chloroflexi	S	Uncharacterized protein conserved in bacteria (DUF2064)	-	-	-	ko:K09931	-	-	-	-	ko00000	-	-	-	DUF2064
HKD2_k127_6285144_0	485913.Krac_7975	9.41e-184	578.0	COG0535@1|root,COG0535@2|Bacteria,2G75Y@200795|Chloroflexi	200795|Chloroflexi	C	Iron-sulfur cluster-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_14,Radical_SAM,SPASM
HKD2_k127_6300884_1	1382306.JNIM01000001_gene974	1.024e-20	93.0	COG0842@1|root,COG0842@2|Bacteria,2G5UH@200795|Chloroflexi	200795|Chloroflexi	V	PFAM ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
HKD2_k127_6300884_0	485913.Krac_7593	3.637e-136	439.0	COG1131@1|root,COG1131@2|Bacteria,2G5YX@200795|Chloroflexi	200795|Chloroflexi	V	PFAM ABC transporter related	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD2_k127_6307925_0	479434.Sthe_2734	1.354e-44	170.0	COG5516@1|root,COG5516@2|Bacteria,2G7GV@200795|Chloroflexi	200795|Chloroflexi	S	Putative stress-induced transcription regulator	-	-	-	-	-	-	-	-	-	-	-	-	ABATE,zf-CGNR
HKD2_k127_6307925_1	1123242.JH636435_gene1923	6.282e-25	111.0	COG2217@1|root,COG2217@2|Bacteria,2IXE1@203682|Planctomycetes	203682|Planctomycetes	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	-	-	-	-	-	-	-	-	-	-	E1-E2_ATPase,Hydrolase
HKD2_k127_6313236_0	485913.Krac_8544	5.229e-97	323.0	COG1187@1|root,COG1187@2|Bacteria,2G6HU@200795|Chloroflexi	200795|Chloroflexi	J	Belongs to the pseudouridine synthase RsuA family	-	-	5.4.99.20,5.4.99.22	ko:K06178,ko:K06181	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
HKD2_k127_6313236_1	1382306.JNIM01000001_gene846	6.14e-26	109.0	COG3224@1|root,COG3224@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K09932	-	-	-	-	ko00000	-	-	-	ABM
HKD2_k127_631603_0	485913.Krac_1326	2.307e-217	681.0	COG0001@1|root,COG0001@2|Bacteria,2G67D@200795|Chloroflexi	200795|Chloroflexi	H	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	hemL	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
HKD2_k127_631603_1	485913.Krac_1327	6.378e-30	119.0	COG3253@1|root,COG3253@2|Bacteria,2G6WY@200795|Chloroflexi	200795|Chloroflexi	S	PFAM Chlorite dismutase	-	-	-	-	-	-	-	-	-	-	-	-	Chlor_dismutase
HKD2_k127_6322269_1	485913.Krac_10548	4.456e-40	152.0	COG0827@1|root,COG1002@1|root,COG0827@2|Bacteria,COG1002@2|Bacteria,2G84A@200795|Chloroflexi	200795|Chloroflexi	LV	Pfam:Methyltransf_26	-	-	-	-	-	-	-	-	-	-	-	-	Eco57I
HKD2_k127_6322269_0	357808.RoseRS_1479	9.723e-130	421.0	COG0553@1|root,COG0553@2|Bacteria,2G6I4@200795|Chloroflexi,376H9@32061|Chloroflexia	32061|Chloroflexia	KL	PLD-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Helicase_C,PLDc_2
HKD2_k127_6324614_1	485913.Krac_10851	2.767e-111	364.0	COG0177@1|root,COG0177@2|Bacteria,2G8JP@200795|Chloroflexi	200795|Chloroflexi	L	FES	-	-	-	-	-	-	-	-	-	-	-	-	HhH-GPD
HKD2_k127_6324614_0	485913.Krac_10856	1.925e-131	422.0	COG1070@1|root,COG1070@2|Bacteria,2G5QX@200795|Chloroflexi	200795|Chloroflexi	G	PFAM carbohydrate kinase	xylB	-	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
HKD2_k127_632486_1	485913.Krac_7545	3.893e-133	428.0	COG0500@1|root,COG2226@2|Bacteria,2G6T6@200795|Chloroflexi	200795|Chloroflexi	H	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2)	menG	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Ubie_methyltran
HKD2_k127_632486_0	485913.Krac_7544	1.216e-160	511.0	COG0142@1|root,COG0142@2|Bacteria,2G6IZ@200795|Chloroflexi	200795|Chloroflexi	H	Belongs to the FPP GGPP synthase family	hepT	-	2.5.1.30,2.5.1.90	ko:K00805,ko:K02523	ko00900,ko01110,map00900,map01110	-	R09247,R09248	RC00279	ko00000,ko00001,ko01000,ko01006	-	-	-	polyprenyl_synt
HKD2_k127_632486_2	485913.Krac_7543	8.98e-26	106.0	COG1313@1|root,COG1313@2|Bacteria,2G65I@200795|Chloroflexi	200795|Chloroflexi	C	Radical SAM domain protein	-	-	1.97.1.4	ko:K04070	-	-	-	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
HKD2_k127_6326030_1	485913.Krac_8034	5.511e-23	99.0	COG3467@1|root,COG3467@2|Bacteria,2G70M@200795|Chloroflexi	200795|Chloroflexi	S	PFAM pyridoxamine 5'-phosphate oxidase-related	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
HKD2_k127_6326030_0	485913.Krac_8040	1.321e-106	353.0	COG2114@1|root,COG2114@2|Bacteria	2|Bacteria	T	Pfam Adenylate and Guanylate cyclase catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	DA1-like,GAF,Guanylate_cyc,HAMP,PAS_4,PAS_9,Response_reg,dCache_1
HKD2_k127_6326030_2	485913.Krac_8043	9.119e-21	92.0	28SF2@1|root,2ZERN@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6326030_3	1120973.AQXL01000074_gene1038	1.66e-05	49.0	COG4770@1|root,COG4770@2|Bacteria,1VEJE@1239|Firmicutes,4HNJG@91061|Bacilli,27ABP@186823|Alicyclobacillaceae	91061|Bacilli	I	Biotin-requiring enzyme	yngHB	-	-	ko:K02160	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742	RC00040,RC00367	ko00000,ko00001,ko00002	-	-	-	Biotin_lipoyl
HKD2_k127_6331340_1	485913.Krac_6720	3.739e-32	130.0	COG0465@1|root,COG0465@2|Bacteria,2G63X@200795|Chloroflexi	2|Bacteria	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009056,GO:0009057,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019538,GO:0030163,GO:0042623,GO:0042802,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
HKD2_k127_6331340_0	1382306.JNIM01000001_gene2536	1.804e-214	678.0	COG3408@1|root,COG3408@2|Bacteria,2G7N3@200795|Chloroflexi	200795|Chloroflexi	G	Glycogen debranching enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Trehalase
HKD2_k127_6331340_2	1382306.JNIM01000001_gene2536	1.457e-25	111.0	COG3408@1|root,COG3408@2|Bacteria,2G7N3@200795|Chloroflexi	200795|Chloroflexi	G	Glycogen debranching enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Trehalase
HKD2_k127_6331340_3	485913.Krac_6717	2.142e-14	74.0	COG0631@1|root,COG0631@2|Bacteria	2|Bacteria	T	protein serine/threonine phosphatase activity	-	-	3.1.3.16	ko:K01090,ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C,PP2C_2
HKD2_k127_6350851_0	485913.Krac_11446	2.065e-282	872.0	COG0753@1|root,COG0753@2|Bacteria,2G804@200795|Chloroflexi	2|Bacteria	C	Catalase domain protein	-	-	1.11.1.6	ko:K03781	ko00380,ko00630,ko01110,ko01130,ko01200,ko04011,ko04016,ko04068,ko04146,ko04211,ko04212,ko04213,ko05014,map00380,map00630,map01110,map01130,map01200,map04011,map04016,map04068,map04146,map04211,map04212,map04213,map05014	M00532	R00009,R00602,R02670	RC00034,RC00767,RC02141,RC02755	ko00000,ko00001,ko00002,ko01000	-	-	-	Catalase,Catalase-rel
HKD2_k127_6357634_1	485913.Krac_9024	2.584e-50	179.0	COG0519@1|root,COG0519@2|Bacteria,2G5WB@200795|Chloroflexi	200795|Chloroflexi	F	Catalyzes the synthesis of GMP from XMP	guaA	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase,GMP_synt_C,NAD_synthase
HKD2_k127_6357634_0	485913.Krac_9025	1.405e-92	311.0	2DSZU@1|root,33I3M@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
HKD2_k127_6357634_2	714943.Mucpa_4740	2.748e-25	109.0	COG0745@1|root,COG0745@2|Bacteria,4NR6P@976|Bacteroidetes,1IYC6@117747|Sphingobacteriia	976|Bacteroidetes	T	response regulator, receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
HKD2_k127_6364541_0	1382306.JNIM01000001_gene3723	5.67e-51	185.0	COG0417@1|root,COG0417@2|Bacteria,2G7ZM@200795|Chloroflexi	200795|Chloroflexi	L	SMART DNA-directed DNA polymerase B	-	-	-	-	-	-	-	-	-	-	-	-	DNA_pol_B,DNA_pol_B_exo1
HKD2_k127_6364541_1	485913.Krac_8112	5.987e-33	135.0	COG1169@1|root,COG1169@2|Bacteria,2G5RQ@200795|Chloroflexi	200795|Chloroflexi	HQ	TIGRFAM isochorismate synthase	-	-	5.4.4.2	ko:K02361,ko:K02552	ko00130,ko01053,ko01100,ko01110,ko01130,map00130,map01053,map01100,map01110,map01130	M00116	R01717	RC00588	ko00000,ko00001,ko00002,ko01000	-	-	-	Chorismate_bind
HKD2_k127_6366621_1	485913.Krac_4426	7.853e-21	98.0	COG2030@1|root,COG2030@2|Bacteria,2G6Y9@200795|Chloroflexi	200795|Chloroflexi	I	MaoC domain protein dehydratase	-	-	2.3.1.19,4.2.1.55	ko:K00634,ko:K17865	ko00630,ko00650,ko01100,ko01120,ko01200,map00630,map00650,map01100,map01120,map01200	M00373	R01174,R03027	RC00004,RC00831,RC02816	ko00000,ko00001,ko00002,ko01000	-	-	-	MaoC_dehydratas,PTA_PTB
HKD2_k127_6366621_0	485913.Krac_10013	1.02e-128	415.0	COG0024@1|root,COG0024@2|Bacteria,2G6AV@200795|Chloroflexi	200795|Chloroflexi	J	TIGRFAM methionine aminopeptidase, type I	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
HKD2_k127_6367783_0	1382306.JNIM01000001_gene841	1e-99	344.0	COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,2G6G7@200795|Chloroflexi	200795|Chloroflexi	S	PFAM ComEC Rec2-related protein	comEC	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Competence,DUF4131,Lactamase_B
HKD2_k127_6367783_2	443143.GM18_3069	3.215e-09	69.0	COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,1MUKF@1224|Proteobacteria,42N3S@68525|delta/epsilon subdivisions,2WJ5P@28221|Deltaproteobacteria,43TMI@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	TIGRFAM DNA internalization-related competence protein ComEC Rec2	-	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Competence,DUF4131,Lactamase_B
HKD2_k127_6367842_0	485913.Krac_5193	2.58e-169	543.0	COG0772@1|root,COG0772@2|Bacteria,2G6NR@200795|Chloroflexi	200795|Chloroflexi	D	Belongs to the SEDS family	-	-	-	-	-	-	-	-	-	-	-	-	FTSW_RODA_SPOVE
HKD2_k127_6367842_1	485913.Krac_11253	7.855e-63	218.0	COG1716@1|root,COG1716@2|Bacteria,2G759@200795|Chloroflexi	200795|Chloroflexi	T	PFAM Forkhead-associated protein	-	-	-	-	-	-	-	-	-	-	-	-	FHA,Yop-YscD_cpl
HKD2_k127_6367842_2	485913.Krac_11252	1.325e-59	211.0	COG1716@1|root,COG1716@2|Bacteria,2G79K@200795|Chloroflexi	200795|Chloroflexi	T	PFAM Forkhead-associated protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF3662,FHA
HKD2_k127_6378710_0	485913.Krac_7561	0.0	1316.0	COG0643@1|root,COG0643@2|Bacteria,2G6G3@200795|Chloroflexi	200795|Chloroflexi	T	ATP-binding region, ATPase domain protein	-	-	2.7.13.3	ko:K02487,ko:K03407,ko:K06596	ko02020,ko02025,ko02030,map02020,map02025,map02030	M00506,M00507	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg
HKD2_k127_6378710_1	1382306.JNIM01000001_gene992	4.645e-175	555.0	COG0473@1|root,COG0473@2|Bacteria,2G63C@200795|Chloroflexi	200795|Chloroflexi	H	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate	leuB	-	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
HKD2_k127_6378710_2	485913.Krac_1553	1.79e-15	76.0	COG3316@1|root,COG3316@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS240
HKD2_k127_6391775_2	485913.Krac_1287	2.741e-44	164.0	29D8F@1|root,3006D@2|Bacteria,2G9H3@200795|Chloroflexi	200795|Chloroflexi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6391775_1	485913.Krac_11177	5.434e-67	234.0	COG1051@1|root,COG1051@2|Bacteria	2|Bacteria	F	GDP-mannose mannosyl hydrolase activity	mutT2	-	3.6.1.55	ko:K03574,ko:K13669	-	-	-	-	ko00000,ko01000,ko01003,ko03400	-	GT87	-	NUDIX
HKD2_k127_6391775_0	1382306.JNIM01000001_gene3429	5.331e-99	331.0	COG0827@1|root,COG1002@1|root,COG0827@2|Bacteria,COG1002@2|Bacteria,2G6FJ@200795|Chloroflexi	200795|Chloroflexi	LV	Eco57I restriction-modification methylase	-	-	2.1.1.72	ko:K07317	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	Eco57I,TaqI_C
HKD2_k127_6398378_1	1121428.DESHY_110553___1	6.712e-18	93.0	COG0728@1|root,COG0728@2|Bacteria,1TPFI@1239|Firmicutes,247N3@186801|Clostridia,2605U@186807|Peptococcaceae	186801|Clostridia	U	Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane	murJ	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
HKD2_k127_6398378_0	383372.Rcas_3083	2.151e-162	523.0	COG0677@1|root,COG0677@2|Bacteria,2G5PP@200795|Chloroflexi,3756K@32061|Chloroflexia	32061|Chloroflexia	M	PFAM UDP-glucose GDP-mannose dehydrogenase	-	-	1.1.1.136	ko:K13015	ko00520,map00520	-	R00421	RC00291	ko00000,ko00001,ko01000,ko01005	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
HKD2_k127_6398378_2	1499684.CCNP01000021_gene2617	9.196e-15	79.0	COG0489@1|root,COG3944@1|root,COG0489@2|Bacteria,COG3944@2|Bacteria,1TS4R@1239|Firmicutes,24B0Z@186801|Clostridia,36DN2@31979|Clostridiaceae	186801|Clostridia	D	Capsular exopolysaccharide family	-	-	-	-	-	-	-	-	-	-	-	-	AAA_31,CbiA,ParA,Wzz
HKD2_k127_6406252_0	485913.Krac_4993	4.637e-175	560.0	COG1376@1|root,COG1376@2|Bacteria	2|Bacteria	D	ErfK ybiS ycfS ynhG family protein	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2,YkuD
HKD2_k127_6407766_2	383372.Rcas_3097	7.199e-38	157.0	COG0297@1|root,COG0297@2|Bacteria,2GBMD@200795|Chloroflexi,37794@32061|Chloroflexia	32061|Chloroflexia	H	PFAM glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
HKD2_k127_6407766_0	1499967.BAYZ01000026_gene1631	2.967e-178	578.0	COG0367@1|root,COG0367@2|Bacteria,2NNKE@2323|unclassified Bacteria	2|Bacteria	E	PFAM asparagine synthase	asnB	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
HKD2_k127_6407766_1	525904.Tter_2795	3.989e-51	195.0	COG0438@1|root,COG0438@2|Bacteria,2NPSJ@2323|unclassified Bacteria	2|Bacteria	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_2,Glyco_transf_4,Glycos_transf_1,Glycos_transf_2
HKD2_k127_6433286_2	485913.Krac_8248	2.2e-59	211.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD2_k127_6433286_5	485913.Krac_8250	7.453e-19	89.0	COG1826@1|root,COG1826@2|Bacteria	2|Bacteria	U	protein secretion	-	-	-	ko:K03116	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
HKD2_k127_6433286_1	485913.Krac_8251	3.271e-96	321.0	COG0805@1|root,COG0805@2|Bacteria,2G6SP@200795|Chloroflexi	200795|Chloroflexi	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes	tatC	-	-	ko:K03118	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	TatC
HKD2_k127_6433286_0	485913.Krac_8252	1.333e-153	497.0	COG0477@1|root,COG2814@2|Bacteria,2G77Q@200795|Chloroflexi	200795|Chloroflexi	EGP	PFAM major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD2_k127_6437106_1	1382306.JNIM01000001_gene518	6.291e-103	341.0	COG0647@1|root,COG0647@2|Bacteria,2G6UI@200795|Chloroflexi	200795|Chloroflexi	G	Haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_6,Hydrolase_like
HKD2_k127_6437106_0	485913.Krac_11754	3.712e-195	615.0	COG0515@1|root,COG0515@2|Bacteria,2G67H@200795|Chloroflexi	200795|Chloroflexi	KLT	SMART serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	FHA,Pkinase
HKD2_k127_6437106_2	485913.Krac_11753	1.536e-56	209.0	COG1716@1|root,COG1716@2|Bacteria,2G8QX@200795|Chloroflexi	200795|Chloroflexi	T	Inner membrane component of T3SS, cytoplasmic domain	-	-	-	-	-	-	-	-	-	-	-	-	FHA
HKD2_k127_6442560_0	1382306.JNIM01000001_gene1964	3.365e-158	504.0	COG0520@1|root,COG0520@2|Bacteria	2|Bacteria	E	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine	ycbU	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
HKD2_k127_6449391_0	1499967.BAYZ01000173_gene5791	3.974e-60	211.0	COG2606@1|root,COG2606@2|Bacteria,2NRI0@2323|unclassified Bacteria	2|Bacteria	S	Aminoacyl-tRNA editing domain	ybaK_1	-	3.4.15.5	ko:K01284	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	tRNA_edit
HKD2_k127_6449391_1	1128421.JAGA01000002_gene435	5.885e-43	170.0	COG2340@1|root,COG3103@1|root,COG2340@2|Bacteria,COG4991@2|Bacteria,2NQ03@2323|unclassified Bacteria	2|Bacteria	T	sh3 domain protein	-	-	-	ko:K07282	-	-	-	-	ko00000	-	-	-	CAP,Glyco_hydro_99,SH3_3,SH3_4
HKD2_k127_6451887_1	485913.Krac_7791	2.056e-116	377.0	COG1100@1|root,COG1100@2|Bacteria,2G6A7@200795|Chloroflexi	200795|Chloroflexi	S	ADP-ribosylation factor family	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6451887_2	485913.Krac_7792	7.1e-111	363.0	COG2197@1|root,COG2197@2|Bacteria,2G6K0@200795|Chloroflexi	200795|Chloroflexi	K	Two component transcriptional regulator, LuxR family	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HKD2_k127_6451887_0	485913.Krac_7793	1.422e-123	398.0	COG0058@1|root,COG0058@2|Bacteria,2G5KG@200795|Chloroflexi	200795|Chloroflexi	G	PFAM glycosyl transferase, family 35	glgP	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	DUF3417,Phosphorylase
HKD2_k127_6454781_0	485913.Krac_12476	3.853e-248	774.0	COG1418@1|root,COG1418@2|Bacteria,2G620@200795|Chloroflexi	200795|Chloroflexi	S	Endoribonuclease that initiates mRNA decay	rny	-	-	ko:K18682	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DUF3552,HD,KH_1
HKD2_k127_6454781_1	485913.Krac_12477	1.764e-120	395.0	COG0613@1|root,COG0613@2|Bacteria,2G6H4@200795|Chloroflexi	200795|Chloroflexi	S	SMART phosphoesterase PHP domain protein	-	-	3.1.3.97	ko:K07053	-	-	R00188,R11188	RC00078	ko00000,ko01000	-	-	-	PHP
HKD2_k127_6454781_2	1382306.JNIM01000001_gene3502	2.103e-66	233.0	COG0681@1|root,COG0681@2|Bacteria,2G701@200795|Chloroflexi	200795|Chloroflexi	U	Belongs to the peptidase S26 family	lepB	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24
HKD2_k127_6461830_2	485913.Krac_8722	3.301e-57	206.0	COG2059@1|root,COG2059@2|Bacteria	2|Bacteria	P	chromate transport	-	-	-	ko:K07240	-	-	-	-	ko00000,ko02000	2.A.51.1	-	-	Chromate_transp
HKD2_k127_6461830_1	485913.Krac_8723	4.865e-65	226.0	COG2059@1|root,COG2059@2|Bacteria	2|Bacteria	P	chromate transport	-	-	-	ko:K07240	-	-	-	-	ko00000,ko02000	2.A.51.1	-	-	Chromate_transp
HKD2_k127_6461830_0	485913.Krac_8725	5.892e-209	658.0	COG2256@1|root,COG2256@2|Bacteria,2G5JC@200795|Chloroflexi	200795|Chloroflexi	L	PFAM AAA ATPase central domain protein	-	-	-	ko:K07478	-	-	-	-	ko00000	-	-	-	AAA,AAA_assoc_2,MgsA_C,RuvB_N
HKD2_k127_6476039_1	485913.Krac_1203	1.991e-205	648.0	COG4262@1|root,COG4262@2|Bacteria,2G5YS@200795|Chloroflexi	200795|Chloroflexi	S	Spermine/spermidine synthase domain	-	-	-	-	-	-	-	-	-	-	-	-	Spermine_synth
HKD2_k127_6476039_2	1499967.BAYZ01000117_gene3325	1.39e-132	435.0	COG0566@1|root,COG0566@2|Bacteria	2|Bacteria	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family	-	-	2.1.1.185	ko:K03218,ko:K03437	-	-	-	-	ko00000,ko01000,ko03009,ko03016	-	-	-	SpoU_methylase,SpoU_sub_bind
HKD2_k127_6476039_0	485913.Krac_1193	0.0	1276.0	COG0383@1|root,COG0383@2|Bacteria,2G5U7@200795|Chloroflexi	200795|Chloroflexi	G	glycosyl hydrolase 38 domain protein	-	-	3.2.1.24	ko:K01191	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04131	-	GH38	-	Alpha-mann_mid,Glyco_hydro_38,Glyco_hydro_38C
HKD2_k127_6506301_0	1382306.JNIM01000001_gene3823	5.213e-110	362.0	COG4149@1|root,COG4149@2|Bacteria,2G6FA@200795|Chloroflexi	200795|Chloroflexi	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02018	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.8	-	-	BPD_transp_1
HKD2_k127_6506301_1	485913.Krac_8923	8.658e-99	330.0	COG0725@1|root,COG0725@2|Bacteria,2G6J6@200795|Chloroflexi	200795|Chloroflexi	P	Molybdenum ABC transporter, periplasmic molybdate-binding protein	modA	-	-	ko:K02020	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.8	-	-	SBP_bac_11
HKD2_k127_6508846_0	1499967.BAYZ01000026_gene1631	5.296e-151	496.0	COG0367@1|root,COG0367@2|Bacteria,2NNKE@2323|unclassified Bacteria	2|Bacteria	E	PFAM asparagine synthase	asnB	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
HKD2_k127_6511393_2	391616.OA238_160p0690	9.82e-24	104.0	COG0154@1|root,COG0154@2|Bacteria,1MZSF@1224|Proteobacteria,2UDFX@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	Gas vesicle synthesis protein GvpL/GvpF	-	-	-	-	-	-	-	-	-	-	-	-	GvpL_GvpF
HKD2_k127_6511393_1	485913.Krac_0300	5.049e-27	115.0	COG1357@1|root,COG1357@2|Bacteria	2|Bacteria	S	protein homooligomerization	-	-	-	-	-	-	-	-	-	-	-	-	Pentapeptide
HKD2_k127_6524004_1	485913.Krac_8676	6.5e-27	114.0	COG1694@1|root,COG3956@2|Bacteria,2G5WH@200795|Chloroflexi	200795|Chloroflexi	S	TIGRFAM MazG family protein	-	-	-	ko:K02499	-	-	-	-	ko00000,ko03036	-	-	-	MazG,TP_methylase
HKD2_k127_6524004_3	1278309.KB907104_gene887	2.536e-11	74.0	COG0596@1|root,COG0596@2|Bacteria,1QUBR@1224|Proteobacteria,1RSF9@1236|Gammaproteobacteria,1XRTD@135619|Oceanospirillales	135619|Oceanospirillales	S	Alpha beta hydrolase	-	-	3.1.1.85	ko:K02170	ko00780,ko01100,map00780,map01100	M00572	R09725	RC00460,RC00461	ko00000,ko00001,ko00002,ko01000	-	-	-	Abhydrolase_1
HKD2_k127_6524004_2	485913.Krac_3720	2.429e-11	72.0	COG0707@1|root,COG0707@2|Bacteria,2G6CA@200795|Chloroflexi	200795|Chloroflexi	M	Glycosyltransferase 28 domain	-	-	2.4.1.46	ko:K03715	ko00561,ko01100,map00561,map01100	-	R02691	RC00005,RC00059	ko00000,ko00001,ko01000,ko01003	-	GT28	-	Glyco_tran_28_C,MGDG_synth
HKD2_k127_6524564_0	485913.Krac_9000	5.191e-236	736.0	COG0148@1|root,COG0148@2|Bacteria,2G5VB@200795|Chloroflexi	200795|Chloroflexi	F	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
HKD2_k127_6524564_1	1382306.JNIM01000001_gene340	2.074e-170	541.0	COG0079@1|root,COG0079@2|Bacteria,2G5U4@200795|Chloroflexi	200795|Chloroflexi	E	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily	hisC	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
HKD2_k127_654450_1	485913.Krac_9259	9.581e-101	336.0	COG1018@1|root,COG1018@2|Bacteria,2G7Q7@200795|Chloroflexi	200795|Chloroflexi	C	PFAM oxidoreductase FAD NAD(P)-binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_6,NAD_binding_1
HKD2_k127_654450_0	1394178.AWOO02000072_gene436	3.066e-183	586.0	COG1070@1|root,COG1070@2|Bacteria,2GNCR@201174|Actinobacteria,4EG34@85012|Streptosporangiales	201174|Actinobacteria	G	FGGY family of carbohydrate kinases, N-terminal domain	-	-	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
HKD2_k127_6547890_1	485913.Krac_6679	5.057e-71	251.0	COG1807@1|root,COG1807@2|Bacteria,2G991@200795|Chloroflexi	200795|Chloroflexi	M	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6547890_0	485913.Krac_6679	9.968e-119	404.0	COG1807@1|root,COG1807@2|Bacteria,2G991@200795|Chloroflexi	200795|Chloroflexi	M	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6555630_1	485913.Krac_10884	1.75e-45	168.0	COG1929@1|root,COG1929@2|Bacteria	2|Bacteria	G	organic acid phosphorylation	glxK	-	2.7.1.165	ko:K00865	ko00260,ko00561,ko00630,ko01100,ko01120,ko01130,map00260,map00561,map00630,map01100,map01120,map01130	-	R08572	RC00002,RC00428	ko00000,ko00001,ko01000	-	-	-	Gly_kinase
HKD2_k127_6555630_0	485913.Krac_7239	1.234e-53	201.0	COG0589@1|root,COG0589@2|Bacteria,2G768@200795|Chloroflexi	200795|Chloroflexi	T	Belongs to the universal stress protein A family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD2_k127_6555630_2	485913.Krac_7176	5.805e-29	121.0	COG0645@1|root,COG2187@1|root,COG0645@2|Bacteria,COG2187@2|Bacteria,2G6D3@200795|Chloroflexi	200795|Chloroflexi	S	AAA domain	-	-	-	ko:K07028	-	-	-	-	ko00000	-	-	-	AAA_33,APH
HKD2_k127_656678_0	1382306.JNIM01000001_gene680	7.004e-102	338.0	COG0323@1|root,COG0323@2|Bacteria,2G8BQ@200795|Chloroflexi	200795|Chloroflexi	L	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex	-	-	-	ko:K03572	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	DNA_mis_repair,HATPase_c,HATPase_c_3,MutL_C
HKD2_k127_656678_1	1382306.JNIM01000001_gene679	1.066e-36	143.0	COG0249@1|root,COG0249@2|Bacteria,2G5IU@200795|Chloroflexi	200795|Chloroflexi	L	that it carries out the mismatch recognition step. This protein has a weak ATPase activity	-	-	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
HKD2_k127_656746_4	1382306.JNIM01000001_gene679	1.608e-37	145.0	COG0249@1|root,COG0249@2|Bacteria,2G5IU@200795|Chloroflexi	200795|Chloroflexi	L	that it carries out the mismatch recognition step. This protein has a weak ATPase activity	-	-	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
HKD2_k127_656746_0	485913.Krac_11190	1.069e-243	766.0	COG0323@1|root,COG0323@2|Bacteria,2G8BQ@200795|Chloroflexi	200795|Chloroflexi	L	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex	-	-	-	ko:K03572	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	DNA_mis_repair,HATPase_c,HATPase_c_3,MutL_C
HKD2_k127_656746_1	485913.Krac_11188	2.394e-150	490.0	COG0477@1|root,COG2814@2|Bacteria,2G8SG@200795|Chloroflexi	200795|Chloroflexi	EGP	PFAM major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD2_k127_656746_6	1382306.JNIM01000001_gene683	2.245e-30	121.0	COG4481@1|root,COG4481@2|Bacteria,2G7GI@200795|Chloroflexi	200795|Chloroflexi	S	Bacterial protein of unknown function (DUF951)	-	-	-	-	-	-	-	-	-	-	-	-	DUF951
HKD2_k127_656746_3	1382306.JNIM01000001_gene684	2.253e-70	245.0	COG1057@1|root,COG1057@2|Bacteria,2G6MY@200795|Chloroflexi	200795|Chloroflexi	F	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)	nadD	-	2.7.7.18	ko:K00969	ko00760,ko01100,map00760,map01100	M00115	R00137,R03005	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
HKD2_k127_656746_5	485913.Krac_11185	1.248e-35	139.0	COG3264@1|root,COG3264@2|Bacteria	2|Bacteria	M	cellular water homeostasis	mscS	-	-	ko:K16052	-	-	-	-	ko00000,ko02000	1.A.23.4	-	-	MS_channel,cNMP_binding
HKD2_k127_6572010_2	485913.Krac_5386	1.3e-07	53.0	COG2272@1|root,COG2272@2|Bacteria	2|Bacteria	I	carboxylic ester hydrolase activity	pnbA	-	-	ko:K03929	-	-	-	-	ko00000,ko01000	-	CE10	-	COesterase
HKD2_k127_6572010_0	477641.MODMU_4005	1.9e-86	297.0	COG2267@1|root,COG2267@2|Bacteria,2GUBM@201174|Actinobacteria,4ESVB@85013|Frankiales	201174|Actinobacteria	I	Serine aminopeptidase, S33	phaB	-	3.1.1.76	ko:K22250	-	-	-	-	ko00000,ko01000	-	-	-	Abhydrolase_1
HKD2_k127_6572010_1	111781.Lepto7376_4274	3.058e-61	222.0	COG0583@1|root,COG0583@2|Bacteria,1G0RE@1117|Cyanobacteria	2|Bacteria	K	Bacterial regulatory helix-turn-helix protein, lysR family	-	-	-	ko:K21960	-	-	-	-	ko00000,ko03000	-	-	-	HTH_1,LysR_substrate
HKD2_k127_6579141_0	1382306.JNIM01000001_gene149	8.128e-139	452.0	COG0477@1|root,COG0477@2|Bacteria	2|Bacteria	EGP	Major facilitator Superfamily	-	-	-	ko:K08176,ko:K08368	-	-	-	-	ko00000,ko02000	2.A.1,2.A.1.9	-	-	Sugar_tr
HKD2_k127_6610393_0	1382306.JNIM01000001_gene2308	1.389e-220	690.0	COG2204@1|root,COG2204@2|Bacteria,2G5ZP@200795|Chloroflexi	200795|Chloroflexi	T	Two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD2_k127_6613630_0	485913.Krac_9140	9.84e-72	245.0	COG0515@1|root,COG0515@2|Bacteria,2G850@200795|Chloroflexi	200795|Chloroflexi	KLT	Serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
HKD2_k127_6613630_1	1382306.JNIM01000001_gene4126	9.765e-58	217.0	COG1705@1|root,COG1705@2|Bacteria	2|Bacteria	NU	amidase activity	-	-	3.5.1.28	ko:K01448,ko:K02395,ko:K17733	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko02035,ko03036	-	-	-	Amidase_2,Amidase_3,CotH,Glucosaminidase,Peptidase_M15_4,Rod-binding
HKD2_k127_6617668_0	1382306.JNIM01000001_gene2537	7.181e-224	710.0	COG0465@1|root,COG0465@2|Bacteria	2|Bacteria	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009056,GO:0009057,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019538,GO:0030163,GO:0042623,GO:0042802,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
HKD2_k127_6625298_2	485913.Krac_11829	8.515e-41	152.0	COG0282@1|root,COG0282@2|Bacteria	2|Bacteria	F	acetate kinase activity	ackA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	2.7.2.1	ko:K00925	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00315,R01353	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv0409	Acetate_kinase
HKD2_k127_6625298_1	485913.Krac_11835	3.073e-81	275.0	COG1595@1|root,COG1595@2|Bacteria,2G6T5@200795|Chloroflexi	200795|Chloroflexi	K	PFAM sigma-70 region 2 domain protein	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD2_k127_6625298_0	485913.Krac_11837	4.908e-103	344.0	COG2227@1|root,COG2227@2|Bacteria	2|Bacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
HKD2_k127_6642652_1	1382306.JNIM01000001_gene347	8.602e-146	474.0	COG3276@1|root,COG3276@2|Bacteria,2G5JX@200795|Chloroflexi	200795|Chloroflexi	J	Selenocysteine-specific translation elongation factor	selB	-	-	ko:K03833	-	-	-	-	ko00000,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,SelB-wing_2,SelB-wing_3
HKD2_k127_6642652_0	1382306.JNIM01000001_gene346	1.172e-199	640.0	COG0515@1|root,COG0515@2|Bacteria,2G67H@200795|Chloroflexi	200795|Chloroflexi	KLT	SMART serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
HKD2_k127_6647462_0	485913.Krac_6717	4.941e-75	263.0	COG0631@1|root,COG0631@2|Bacteria	2|Bacteria	T	protein serine/threonine phosphatase activity	-	-	3.1.3.16	ko:K01090,ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C,PP2C_2
HKD2_k127_6647462_1	266117.Rxyl_3170	3.049e-59	218.0	COG0477@1|root,COG2814@2|Bacteria,2H6FB@201174|Actinobacteria	201174|Actinobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD2_k127_6661793_0	525904.Tter_2605	3.245e-107	354.0	COG1472@1|root,COG1472@2|Bacteria,2NNZB@2323|unclassified Bacteria	2|Bacteria	G	Glycoside hydrolase family 3 domain protein	-	-	3.2.1.52	ko:K01207	ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501	M00628	R00022,R05963,R07809,R07810,R10831	RC00049	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyco_hydro_3,Glyco_hydro_3_C
HKD2_k127_6665043_1	485913.Krac_9791	7.032e-90	304.0	COG0531@1|root,COG0531@2|Bacteria	2|Bacteria	E	amino acid	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6665043_0	485913.Krac_9792	9.548e-130	416.0	COG0745@1|root,COG0745@2|Bacteria,2G6JP@200795|Chloroflexi	200795|Chloroflexi	K	COGs COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	-	-	-	ko:K07667	ko02020,ko02024,map02020,map02024	M00454	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
HKD2_k127_6675822_2	1382306.JNIM01000001_gene2649	3.398e-21	94.0	COG0547@1|root,COG0547@2|Bacteria,2G5YV@200795|Chloroflexi	200795|Chloroflexi	F	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)	trpD	GO:0000162,GO:0003674,GO:0003824,GO:0004048,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.4.2.18	ko:K00766	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R01073	RC00440	ko00000,ko00001,ko00002,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3
HKD2_k127_6675822_0	1382306.JNIM01000001_gene2647	1.861e-93	311.0	COG0512@1|root,COG0512@2|Bacteria,2G69G@200795|Chloroflexi	200795|Chloroflexi	EH	TIGRFAM glutamine amidotransferase of anthranilate synthase	trpG	-	4.1.3.27	ko:K01658	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
HKD2_k127_6675822_1	1382306.JNIM01000001_gene2646	1.399e-61	214.0	COG0147@1|root,COG0147@2|Bacteria,2G5M7@200795|Chloroflexi	200795|Chloroflexi	H	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia	trpE	-	4.1.3.27	ko:K01657	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
HKD2_k127_6680936_0	1382306.JNIM01000001_gene1277	7.561e-221	698.0	COG4166@1|root,COG4166@2|Bacteria,2G5TA@200795|Chloroflexi	200795|Chloroflexi	E	PFAM Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035,ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	SBP_bac_5
HKD2_k127_6680936_2	485913.Krac_2059	2.697e-17	84.0	COG4166@1|root,COG4166@2|Bacteria,2G5TA@200795|Chloroflexi	200795|Chloroflexi	E	PFAM Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035,ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	SBP_bac_5
HKD2_k127_6693999_0	485913.Krac_12024	3.28e-114	376.0	COG1063@1|root,COG1063@2|Bacteria,2G5WZ@200795|Chloroflexi	200795|Chloroflexi	E	Alcohol dehydrogenase GroES domain protein	-	-	1.1.1.1	ko:K00001	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
HKD2_k127_6696567_2	485913.Krac_8513	2.145e-61	218.0	COG1836@1|root,COG1836@2|Bacteria,2G6N3@200795|Chloroflexi	200795|Chloroflexi	S	Integral membrane protein DUF92	-	-	-	-	-	-	-	-	-	-	-	-	DUF92
HKD2_k127_6696567_1	485913.Krac_8512	9.467e-65	224.0	COG4570@1|root,COG4570@2|Bacteria,2G8U7@200795|Chloroflexi	200795|Chloroflexi	L	Endodeoxyribonuclease RusA	-	-	3.1.22.4	ko:K01160	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	RusA
HKD2_k127_6700375_0	485913.Krac_1212	0.0	1125.0	COG4867@1|root,COG4867@2|Bacteria,2G8A6@200795|Chloroflexi	200795|Chloroflexi	S	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6700375_1	485913.Krac_1213	1.047e-254	789.0	COG1239@1|root,COG1239@2|Bacteria	2|Bacteria	H	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX	chlI	-	6.6.1.1	ko:K03405	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R03877	RC01012	ko00000,ko00001,ko01000	-	-	iNJ661.Rv0958	Mg_chelatase,Sigma54_activat
HKD2_k127_6700375_2	485913.Krac_1214	9.669e-110	360.0	COG0531@1|root,COG0531@2|Bacteria,2G5ZF@200795|Chloroflexi	2|Bacteria	E	Amino acid permease	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
HKD2_k127_6702351_0	485913.Krac_11909	2.023e-249	794.0	COG2274@1|root,COG2274@2|Bacteria,2G84I@200795|Chloroflexi	200795|Chloroflexi	V	peptidase C39 bacteriocin processing	-	-	-	-	-	-	-	-	-	-	-	-	ABC_membrane,ABC_tran,Peptidase_C39
HKD2_k127_6702473_1	485913.Krac_8966	6.91e-112	370.0	COG0515@1|root,COG0515@2|Bacteria,2G7ZS@200795|Chloroflexi	485913.Krac_8966|-	KLT	Serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6702473_2	485913.Krac_8967	8.811e-44	162.0	COG0234@1|root,COG0234@2|Bacteria,2G6WW@200795|Chloroflexi	200795|Chloroflexi	O	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter	groS	-	-	ko:K04078	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Cpn10
HKD2_k127_6702473_0	485913.Krac_8968	1.7e-279	866.0	COG0459@1|root,COG0459@2|Bacteria,2G65N@200795|Chloroflexi	200795|Chloroflexi	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groEL	-	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
HKD2_k127_6719574_1	485913.Krac_8706	1.993e-174	555.0	COG1195@1|root,COG1195@2|Bacteria,2G60N@200795|Chloroflexi	200795|Chloroflexi	L	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP	recF	GO:0000731,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0018130,GO:0019438,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:1901360,GO:1901362,GO:1901576	-	ko:K03629	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	SMC_N
HKD2_k127_6719574_0	485913.Krac_8705	2.246e-184	582.0	COG0592@1|root,COG0592@2|Bacteria,2G641@200795|Chloroflexi	200795|Chloroflexi	L	Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria	dnaN	-	2.7.7.7	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3
HKD2_k127_6722528_0	485913.Krac_12273	2.838e-144	464.0	COG0223@1|root,COG0223@2|Bacteria,2G69J@200795|Chloroflexi	200795|Chloroflexi	J	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus	fmt	GO:0003674,GO:0003824,GO:0004479,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006413,GO:0006464,GO:0006518,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016742,GO:0019538,GO:0019988,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0043043,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0071704,GO:0071951,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	-	Formyl_trans_C,Formyl_trans_N
HKD2_k127_6722528_1	485913.Krac_12274	1.045e-126	411.0	COG1968@1|root,COG1968@2|Bacteria,2G6F7@200795|Chloroflexi	200795|Chloroflexi	V	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin	uppP	-	3.6.1.27	ko:K06153	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	BacA
HKD2_k127_6757478_1	485913.Krac_11909	4.761e-58	210.0	COG2274@1|root,COG2274@2|Bacteria,2G84I@200795|Chloroflexi	200795|Chloroflexi	V	peptidase C39 bacteriocin processing	-	-	-	-	-	-	-	-	-	-	-	-	ABC_membrane,ABC_tran,Peptidase_C39
HKD2_k127_6757478_0	118168.MC7420_5497	6.941e-86	291.0	COG4403@1|root,COG4403@2|Bacteria,1G04S@1117|Cyanobacteria,1H8RC@1150|Oscillatoriales	1117|Cyanobacteria	V	Lanthionine synthetase C-like protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF4135,LANC_like
HKD2_k127_6763322_0	485913.Krac_8831	2.606e-97	325.0	2DM3D@1|root,31J5I@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF2785)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2785
HKD2_k127_6763322_1	485913.Krac_8832	4.249e-38	146.0	COG0745@1|root,COG0745@2|Bacteria	485913.Krac_8832|-	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6763322_2	1123320.KB889664_gene977	5.888e-38	147.0	COG2141@1|root,COG2141@2|Bacteria,2GKRH@201174|Actinobacteria	201174|Actinobacteria	C	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
HKD2_k127_6771069_2	1449048.JQKU01000001_gene1950	1.832e-36	145.0	28PII@1|root,32WVR@2|Bacteria,2GTGX@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF4255)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4255
HKD2_k127_6771069_3	1449048.JQKU01000001_gene1949	3.575e-15	87.0	2EA5X@1|root,334AT@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6771069_0	485913.Krac_8099	1.07e-113	376.0	COG3335@1|root,COG3335@2|Bacteria,2G8GI@200795|Chloroflexi	200795|Chloroflexi	L	SPTR Q2LSA8 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3
HKD2_k127_6771069_1	485913.Krac_0282	3.334e-76	256.0	COG3415@1|root,COG3415@2|Bacteria,2G9BT@200795|Chloroflexi	200795|Chloroflexi	L	SPTR B0JN73 Transposase	-	-	-	-	-	-	-	-	-	-	-	-	HTH_32
HKD2_k127_6778292_0	485913.Krac_6283	2.785e-194	613.0	COG5002@1|root,COG5002@2|Bacteria	2|Bacteria	T	protein histidine kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,HTH_Crp_2,HisKA,PAS,PAS_4,PAS_9,Reg_prop,SpoIIE,Y_Y_Y
HKD2_k127_6778292_1	485913.Krac_10174	8.461e-116	383.0	COG1376@1|root,COG1376@2|Bacteria	2|Bacteria	D	ErfK ybiS ycfS ynhG family protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF5011,LysM,YkuD
HKD2_k127_6785683_6	1343739.PAP_07525	2.528e-36	145.0	COG0494@1|root,arCOG01083@2157|Archaea	2157|Archaea	L	COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes	-	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX
HKD2_k127_6785683_2	485913.Krac_11285	5.5e-136	441.0	COG1649@1|root,COG1649@2|Bacteria	2|Bacteria	F	PFAM Uncharacterised BCR, COG1649	-	-	3.2.1.11,3.2.1.18,3.2.1.35,4.2.2.23	ko:K01186,ko:K01197,ko:K05988,ko:K11931,ko:K18197	ko00500,ko00511,ko00531,ko00600,ko01100,ko02026,ko04142,map00500,map00511,map00531,map00600,map01100,map02026,map04142	M00076,M00077	R04018,R07824,R07825,R10905,R11309	RC00028,RC00077	ko00000,ko00001,ko00002,ko00536,ko00537,ko01000,ko02042	-	GH33,GH66,PL11	-	DUF1349,GHL10,Glyco_hydro_20b,Laminin_G_3,NAGidase,fn3
HKD2_k127_6785683_3	485913.Krac_11286	6.837e-106	351.0	COG1947@1|root,COG1947@2|Bacteria,2G71D@200795|Chloroflexi	200795|Chloroflexi	F	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol	ispE	-	2.7.1.148	ko:K00919	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05634	RC00002,RC01439	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
HKD2_k127_6785683_0	485913.Krac_11287	1.054e-180	572.0	COG0859@1|root,COG0859@2|Bacteria,2G8MX@200795|Chloroflexi	200795|Chloroflexi	M	Glycosyltransferase family 9 (heptosyltransferase)	-	-	-	ko:K02843	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9
HKD2_k127_6785683_1	485913.Krac_11288	4.151e-164	526.0	COG0859@1|root,COG0859@2|Bacteria,2G6JB@200795|Chloroflexi	200795|Chloroflexi	M	PFAM glycosyl transferase family 9	-	-	-	ko:K02843,ko:K02849	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9
HKD2_k127_6785683_5	485913.Krac_4139	5.238e-37	145.0	COG0675@1|root,COG0675@2|Bacteria,2G89V@200795|Chloroflexi	200795|Chloroflexi	L	TIGRFAM transposase, IS605 OrfB family	-	-	-	ko:K07496	-	-	-	-	ko00000	-	-	-	HTH_OrfB_IS605,OrfB_IS605,OrfB_Zn_ribbon
HKD2_k127_6788419_1	485913.Krac_12284	5.026e-104	344.0	COG0849@1|root,COG0849@2|Bacteria	2|Bacteria	D	cell division	-	-	-	-	-	-	-	-	-	-	-	-	FtsA
HKD2_k127_6788419_0	485913.Krac_12285	0.0	1409.0	COG0013@1|root,COG0013@2|Bacteria,2G5KW@200795|Chloroflexi	200795|Chloroflexi	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
HKD2_k127_6789306_0	485913.Krac_5258	7.757e-242	766.0	COG5002@1|root,COG5002@2|Bacteria	2|Bacteria	T	protein histidine kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	CheB_methylest,CheR,CheR_N,GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9
HKD2_k127_6789306_2	485913.Krac_6634	2.216e-81	278.0	COG1842@1|root,COG1842@2|Bacteria,2G8QB@200795|Chloroflexi	200795|Chloroflexi	KT	PFAM PspA IM30 family protein	-	-	-	ko:K03969	-	-	-	-	ko00000	-	-	-	PspA_IM30
HKD2_k127_6789306_1	485913.Krac_6637	1.84e-134	433.0	COG0243@1|root,COG0243@2|Bacteria,2G5X7@200795|Chloroflexi	200795|Chloroflexi	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
HKD2_k127_6792143_4	485913.Krac_6805	4.81e-104	340.0	COG0353@1|root,COG0353@2|Bacteria,2G6CT@200795|Chloroflexi	200795|Chloroflexi	L	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO	recR	-	-	ko:K06187	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	HHH,RecR,Toprim_4
HKD2_k127_6792143_0	485913.Krac_6803	8.814e-191	601.0	COG0468@1|root,COG0468@2|Bacteria,2G5WE@200795|Chloroflexi	200795|Chloroflexi	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage	recA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K03553	ko03440,map03440	M00729	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	RecA
HKD2_k127_6792143_3	1382306.JNIM01000001_gene2592	2.543e-113	371.0	COG1028@1|root,COG1028@2|Bacteria,2G8S6@200795|Chloroflexi	200795|Chloroflexi	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HKD2_k127_6792143_1	485913.Krac_6798	7.41e-161	512.0	COG0604@1|root,COG0604@2|Bacteria,2G6DS@200795|Chloroflexi	200795|Chloroflexi	C	Zinc-binding dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
HKD2_k127_6792143_2	485913.Krac_6795	1.879e-158	501.0	COG1013@1|root,COG1013@2|Bacteria,2G679@200795|Chloroflexi	200795|Chloroflexi	C	PFAM thiamine pyrophosphate protein domain protein TPP-binding	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFO_beta_C,TPP_enzyme_C
HKD2_k127_6792143_5	485913.Krac_6794	9.497e-61	210.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,2G69H@200795|Chloroflexi	200795|Chloroflexi	C	Pyruvate flavodoxin ferredoxin oxidoreductase domain protein	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR,POR_N
HKD2_k127_6801267_3	485913.Krac_8151	1.526e-35	142.0	COG1071@1|root,COG1071@2|Bacteria,2G5SF@200795|Chloroflexi	200795|Chloroflexi	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	pdhA	-	1.2.4.1	ko:K00161	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
HKD2_k127_6801267_2	485913.Krac_3058	4.829e-89	302.0	COG0463@1|root,COG0463@2|Bacteria,2G6TA@200795|Chloroflexi	200795|Chloroflexi	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HKD2_k127_6801267_0	1382306.JNIM01000001_gene2719	1.013e-150	491.0	COG1520@1|root,COG1520@2|Bacteria	2|Bacteria	S	amino acid activation for nonribosomal peptide biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	CBM_2,Esterase,PQQ_2
HKD2_k127_6801267_1	485913.Krac_12300	2.548e-122	402.0	COG1131@1|root,COG1131@2|Bacteria,2G6B8@200795|Chloroflexi	200795|Chloroflexi	V	PFAM ABC transporter related	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD2_k127_6801267_4	485913.Krac_12301	3.992e-20	98.0	29XJT@1|root,30JAV@2|Bacteria,2G9T6@200795|Chloroflexi	485913.Krac_12301|-	S	ABC-2 family transporter protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6804358_1	485913.Krac_8584	3.18e-52	189.0	COG0791@1|root,COG0791@2|Bacteria	2|Bacteria	M	cysteine-type peptidase activity	-	-	-	ko:K21471	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	CHAP,CW_binding_1,NLPC_P60
HKD2_k127_6804358_0	485913.Krac_8583	2.009e-134	434.0	COG0506@1|root,COG0506@2|Bacteria,2G6B6@200795|Chloroflexi	200795|Chloroflexi	C	Proline dehydrogenase	-	-	-	ko:K00318	ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130	-	R10507	RC00083	ko00000,ko00001,ko01000	-	-	-	Pro_dh
HKD2_k127_6808834_0	485913.Krac_11726	4.589e-123	402.0	COG0318@1|root,COG3321@1|root,COG0318@2|Bacteria,COG3321@2|Bacteria,2G68I@200795|Chloroflexi	200795|Chloroflexi	IQ	PFAM short-chain dehydrogenase reductase SDR	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,Acyl_transf_1,KAsynt_C_assoc,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
HKD2_k127_6808834_1	485913.Krac_11725	5.976e-88	293.0	COG0236@1|root,COG1028@1|root,COG2141@1|root,COG0236@2|Bacteria,COG1028@2|Bacteria,COG2141@2|Bacteria	2|Bacteria	C	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases	acpP	GO:0000035,GO:0000036,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016053,GO:0019637,GO:0019752,GO:0019842,GO:0031177,GO:0032787,GO:0033218,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044620,GO:0046394,GO:0046467,GO:0046493,GO:0048037,GO:0051192,GO:0071704,GO:0072330,GO:0072341,GO:0090407,GO:0140104,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	-	ko:K02078,ko:K13611,ko:K15337	-	-	-	-	ko00000,ko00001,ko01004,ko01008	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Aminotran_3,Bac_luciferase,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt
HKD2_k127_6812455_9	1382306.JNIM01000001_gene1259	3.79e-51	186.0	COG2267@1|root,COG2267@2|Bacteria,2G6W2@200795|Chloroflexi	200795|Chloroflexi	I	PFAM alpha beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
HKD2_k127_6812455_2	485913.Krac_10963	1.059e-128	414.0	COG0217@1|root,COG0217@2|Bacteria,2G6AI@200795|Chloroflexi	200795|Chloroflexi	K	transcriptional regulatory protein	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	-	-	-	-	-	-	-	-	-	Transcrip_reg
HKD2_k127_6812455_8	485913.Krac_10964	3.022e-77	263.0	COG0817@1|root,COG0817@2|Bacteria,2G6MA@200795|Chloroflexi	200795|Chloroflexi	L	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group	ruvC	GO:0000725,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008821,GO:0009058,GO:0009059,GO:0009987,GO:0016787,GO:0016788,GO:0016889,GO:0016894,GO:0031297,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0045005,GO:0046483,GO:0048476,GO:0050896,GO:0051716,GO:0071704,GO:0071932,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901576	3.1.22.4	ko:K01159	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvC
HKD2_k127_6812455_7	485913.Krac_10965	2.27e-82	278.0	COG0632@1|root,COG0632@2|Bacteria,2G6V7@200795|Chloroflexi	200795|Chloroflexi	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB	ruvA	-	3.6.4.12	ko:K03550	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HHH_5,RuvA_C,RuvA_N
HKD2_k127_6812455_3	1382306.JNIM01000001_gene2623	3.93e-121	397.0	COG0611@1|root,COG0611@2|Bacteria,2G6SH@200795|Chloroflexi	200795|Chloroflexi	H	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1	thiL	-	2.7.4.16	ko:K00946	ko00730,ko01100,map00730,map01100	M00127	R00617	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
HKD2_k127_6812455_5	485913.Krac_10987	2.221e-115	381.0	COG2199@1|root,COG3706@2|Bacteria,2G8GT@200795|Chloroflexi	200795|Chloroflexi	T	PFAM GGDEF domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,Response_reg
HKD2_k127_6812455_6	485913.Krac_10988	5.328e-102	336.0	COG2945@1|root,COG2945@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K07018	-	-	-	-	ko00000	-	-	-	Hydrolase_4
HKD2_k127_6812455_0	485913.Krac_10989	1.605e-287	890.0	COG1061@1|root,COG1061@2|Bacteria,2G861@200795|Chloroflexi	200795|Chloroflexi	L	type III restriction protein res subunit	-	-	3.6.4.12	ko:K10843	ko03022,ko03420,map03022,map03420	M00290	-	-	ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	ERCC3_RAD25_C,Helicase_C_3,ResIII
HKD2_k127_6812455_12	485913.Krac_10990	2.155e-36	140.0	COG3118@1|root,COG3118@2|Bacteria	2|Bacteria	O	belongs to the thioredoxin family	trxA3	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
HKD2_k127_6812455_1	485913.Krac_10991	2.114e-149	480.0	COG1482@1|root,COG1482@2|Bacteria,2G6I2@200795|Chloroflexi	200795|Chloroflexi	G	PFAM mannose-6-phosphate isomerase type I	-	-	5.3.1.8	ko:K01809	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114	R01819	RC00376	ko00000,ko00001,ko00002,ko01000	-	-	-	PMI_typeI
HKD2_k127_6812455_4	485913.Krac_11460	3.687e-120	412.0	2CHUW@1|root,2ZECY@2|Bacteria,2G9K0@200795|Chloroflexi	200795|Chloroflexi	S	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HKD2_k127_6812455_14	485913.Krac_10993	1.301e-06	51.0	COG0498@1|root,COG0498@2|Bacteria,2G66Y@200795|Chloroflexi	200795|Chloroflexi	E	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine	thrC	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HKD2_k127_6820413_0	485913.Krac_9226	7.004e-256	804.0	COG2239@1|root,COG2239@2|Bacteria,2G6H7@200795|Chloroflexi	200795|Chloroflexi	P	Acts as a magnesium transporter	-	-	-	ko:K06213	-	-	-	-	ko00000,ko02000	1.A.26.1	-	-	CBS,MgtE,MgtE_N
HKD2_k127_6820413_3	485913.Krac_9227	5.907e-104	342.0	COG0125@1|root,COG0125@2|Bacteria	2|Bacteria	F	dTDP biosynthetic process	tmk	GO:0000166,GO:0000287,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0004798,GO:0005488,GO:0005515,GO:0005524,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009129,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009161,GO:0009165,GO:0009173,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009218,GO:0009219,GO:0009221,GO:0009259,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0017076,GO:0018130,GO:0019001,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0019693,GO:0030554,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046044,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046872,GO:0046940,GO:0046983,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.7.4.9,4.1.1.19	ko:K00943,ko:K01585	ko00240,ko00330,ko01100,map00240,map00330,map01100	M00053,M00133	R00566,R02094,R02098	RC00002,RC00299	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS00680,iJN746.PP_3363,iNJ661.Rv3247c	AAA_33,Thymidylate_kin
HKD2_k127_6820413_2	485913.Krac_9228	7.613e-114	372.0	COG0125@1|root,COG0125@2|Bacteria	2|Bacteria	F	dTDP biosynthetic process	tmk	GO:0000166,GO:0000287,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0004798,GO:0005488,GO:0005515,GO:0005524,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009129,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009161,GO:0009165,GO:0009173,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009218,GO:0009219,GO:0009221,GO:0009259,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0017076,GO:0018130,GO:0019001,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0019693,GO:0030554,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046044,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046872,GO:0046940,GO:0046983,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.1.1.45,2.7.4.9,4.1.1.19	ko:K00560,ko:K00943,ko:K01585	ko00240,ko00330,ko00670,ko01100,ko01523,map00240,map00330,map00670,map01100,map01523	M00053,M00133	R00566,R02094,R02098,R02101	RC00002,RC00219,RC00299,RC00332	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS00680,iJN746.PP_3363,iNJ661.Rv3247c	AAA_33,Thymidylate_kin
HKD2_k127_6820413_4	1382306.JNIM01000001_gene3896	1.042e-94	314.0	COG2945@1|root,COG2945@2|Bacteria,2G9MQ@200795|Chloroflexi	200795|Chloroflexi	S	hydrolase of the alpha beta	-	-	-	ko:K07018	-	-	-	-	ko00000	-	-	-	Hydrolase_4
HKD2_k127_6820413_1	485913.Krac_2200	3.658e-165	529.0	COG0515@1|root,COG2319@1|root,COG0515@2|Bacteria,COG2319@2|Bacteria	2|Bacteria	S	anaphase-promoting complex binding	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos,NACHT,PD40,Pentapeptide,Pkinase,TIR_2,WD40
HKD2_k127_6825238_2	63737.Npun_R3710	1.991e-17	81.0	COG5485@1|root,COG5485@2|Bacteria	2|Bacteria	S	SnoaL-like polyketide cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese,SnoaL
HKD2_k127_6825238_0	485913.Krac_5031	1.591e-148	489.0	COG4934@1|root,COG4934@2|Bacteria	2|Bacteria	O	collagen metabolic process	-	-	-	ko:K08677	-	-	-	-	ko00000,ko01002	-	-	-	Peptidase_S8,Pro-kuma_activ
HKD2_k127_6825238_1	485913.Krac_0003	1.162e-97	324.0	COG0855@1|root,COG0855@2|Bacteria,2G68J@200795|Chloroflexi	200795|Chloroflexi	H	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)	ppk	-	2.7.4.1	ko:K00937	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PP_kinase,PP_kinase_C,PP_kinase_N
HKD2_k127_6832851_0	1382306.JNIM01000001_gene1241	4.277e-165	524.0	COG0028@1|root,COG0028@2|Bacteria,2G5Q7@200795|Chloroflexi	200795|Chloroflexi	H	Thiamine pyrophosphate protein TPP binding domain protein	ilvB	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
HKD2_k127_6832851_2	485913.Krac_10997	5.934e-50	183.0	COG0440@1|root,COG0440@2|Bacteria,2G6NW@200795|Chloroflexi	200795|Chloroflexi	E	Acetolactate synthase, small subunit	ilvN	-	2.2.1.6	ko:K01653	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT_5,ALS_ss_C
HKD2_k127_6832851_1	1382306.JNIM01000001_gene1243	1.262e-99	327.0	COG0059@1|root,COG0059@2|Bacteria,2G5NP@200795|Chloroflexi	200795|Chloroflexi	H	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate	ilvC	-	1.1.1.86	ko:K00053	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R03051,R04439,R04440,R05068,R05069,R05071	RC00726,RC00836,RC00837,RC01726	ko00000,ko00001,ko00002,ko01000	-	-	-	IlvC,IlvN
HKD2_k127_6839946_1	485913.Krac_7500	1.581e-41	156.0	29XJV@1|root,30JAX@2|Bacteria,2G9FG@200795|Chloroflexi	200795|Chloroflexi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6839946_2	485913.Krac_7501	6.29e-40	148.0	COG0316@1|root,COG0316@2|Bacteria,2G705@200795|Chloroflexi	200795|Chloroflexi	S	Belongs to the HesB IscA family	-	-	-	ko:K13628	-	-	-	-	ko00000,ko03016	-	-	-	Fe-S_biosyn
HKD2_k127_6854384_0	1348338.ADILRU_1322	4.142e-71	255.0	COG0446@1|root,COG0446@2|Bacteria,2GJKT@201174|Actinobacteria,4FKEU@85023|Microbacteriaceae	201174|Actinobacteria	S	Pyridine nucleotide-disulphide oxidoreductase	fprD	-	1.18.1.3	ko:K00529	ko00071,ko00360,ko01120,ko01220,map00071,map00360,map01120,map01220	M00545	R02000,R06782,R06783	RC00098	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	Pyr_redox_2,Reductase_C
HKD2_k127_6860450_1	485913.Krac_12010	2.452e-89	301.0	COG1385@1|root,COG1385@2|Bacteria,2G70G@200795|Chloroflexi	200795|Chloroflexi	J	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit	-	-	2.1.1.193	ko:K09761	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_RNA
HKD2_k127_6860450_0	485913.Krac_12011	3.074e-120	392.0	COG2264@1|root,COG2264@2|Bacteria,2G69X@200795|Chloroflexi	200795|Chloroflexi	J	Ribosomal protein L11 methyltransferase	prmA	-	-	ko:K02687	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PrmA
HKD2_k127_6869588_0	485913.Krac_11053	5.818e-150	491.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	-	-	-	-	-	-	-	-	-	F5_F8_type_C,GxGYxYP_C,GxGYxYP_N
HKD2_k127_6869588_1	1125779.HMPREF1219_01041	1.749e-35	144.0	COG0328@1|root,COG0406@1|root,COG0328@2|Bacteria,COG0406@2|Bacteria,2GJ9R@201174|Actinobacteria,22K8J@1653|Corynebacteriaceae	201174|Actinobacteria	GL	Ribonuclease HI	rnhA	GO:0003674,GO:0003676,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005488,GO:0006139,GO:0006401,GO:0006725,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016070,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016891,GO:0016893,GO:0017144,GO:0018130,GO:0019438,GO:0019439,GO:0032296,GO:0033013,GO:0033014,GO:0034641,GO:0034655,GO:0042364,GO:0042578,GO:0043170,GO:0043755,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0046700,GO:0051186,GO:0051188,GO:0071667,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901575,GO:1901576	3.1.26.4,3.1.3.73	ko:K02226,ko:K22316	ko00860,ko01100,ko03030,map00860,map01100,map03030	M00122	R04594,R11173	RC00017	ko00000,ko00001,ko00002,ko01000,ko03032	-	-	-	His_Phos_1,RVT_3
HKD2_k127_6883837_0	485913.Krac_7773	7.76e-227	707.0	COG0821@1|root,COG0821@2|Bacteria,2G5SC@200795|Chloroflexi	200795|Chloroflexi	I	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate	ispG	-	1.17.7.1,1.17.7.3	ko:K03526	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R08689,R10859	RC01486	ko00000,ko00001,ko00002,ko01000	-	-	-	GcpE
HKD2_k127_6883837_1	485913.Krac_7774	6.616e-33	128.0	COG0750@1|root,COG0750@2|Bacteria,2G6HV@200795|Chloroflexi	200795|Chloroflexi	M	TIGRFAM membrane-associated zinc metalloprotease	-	-	-	ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_M50
HKD2_k127_6893972_0	485913.Krac_10921	2.065e-163	522.0	COG1293@1|root,COG1293@2|Bacteria,2G5TC@200795|Chloroflexi	200795|Chloroflexi	K	Fibronectin-binding A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF814,FbpA
HKD2_k127_690167_0	485913.Krac_6735	1.948e-106	365.0	COG1413@1|root,COG1413@2|Bacteria	2|Bacteria	C	deoxyhypusine monooxygenase activity	-	-	3.2.1.18	ko:K01186	ko00511,ko00600,ko04142,map00511,map00600,map04142	-	R04018	RC00028,RC00077	ko00000,ko00001,ko01000,ko02042	-	GH33	-	HEAT_2,HEAT_PBS
HKD2_k127_690167_2	485913.Krac_6736	1.358e-90	304.0	COG0785@1|root,COG0785@2|Bacteria,2G6V3@200795|Chloroflexi	200795|Chloroflexi	O	PFAM cytochrome c biogenesis protein, transmembrane region	ccdA	-	-	ko:K06196	-	-	-	-	ko00000,ko02000	5.A.1.2	-	-	DsbD
HKD2_k127_690167_1	485913.Krac_6739	1.347e-99	328.0	COG1595@1|root,COG1595@2|Bacteria,2G90X@200795|Chloroflexi	200795|Chloroflexi	K	Sigma-70 region 2	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD2_k127_6912233_0	485913.Krac_8750	7.677e-103	338.0	COG0491@1|root,COG0491@2|Bacteria,2G6X9@200795|Chloroflexi	200795|Chloroflexi	S	beta-lactamase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HKD2_k127_6912233_1	485913.Krac_8749	7.732e-25	105.0	COG1004@1|root,COG1004@2|Bacteria,2G62F@200795|Chloroflexi	200795|Chloroflexi	C	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	-	-	1.1.1.22	ko:K00012	ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100	M00014,M00129,M00361,M00362	R00286	RC00291	ko00000,ko00001,ko00002,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
HKD2_k127_6914345_0	485913.Krac_10793	1.14e-307	950.0	COG3387@1|root,COG3387@2|Bacteria,2G7S0@200795|Chloroflexi	2|Bacteria	G	COGs COG3387 Glucoamylase and related glycosyl hydrolase	-	-	-	ko:K07190	ko04020,ko04910,ko04922,map04020,map04910,map04922	-	-	-	ko00000,ko00001	-	-	-	Glyco_hydro_15
HKD2_k127_6929653_2	1157490.EL26_21895	4.853e-31	128.0	COG0491@1|root,COG0491@2|Bacteria,1V8JE@1239|Firmicutes,4HIYW@91061|Bacilli	91061|Bacilli	S	COG0491 Zn-dependent hydrolases, including glyoxylases	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HKD2_k127_6929653_0	485913.Krac_5169	5.012e-92	309.0	COG3828@1|root,COG3828@2|Bacteria	2|Bacteria	N	Trehalose utilisation	-	-	-	ko:K09992	-	-	-	-	ko00000	-	-	-	CBM_6,Glyco_hydro_99,ThuA
HKD2_k127_6929653_1	485913.Krac_9150	8.073e-55	194.0	COG0277@1|root,COG0277@2|Bacteria,2G5TM@200795|Chloroflexi	200795|Chloroflexi	C	PFAM FAD linked oxidase domain protein	-	-	1.1.2.4	ko:K00102	ko00620,map00620	-	R00197	RC00044	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
HKD2_k127_6940806_1	485913.Krac_9087	1.11e-79	268.0	COG0242@1|root,COG0242@2|Bacteria,2G6VE@200795|Chloroflexi	200795|Chloroflexi	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions	def	GO:0003674,GO:0003824,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0018193,GO:0018206,GO:0019538,GO:0031365,GO:0036211,GO:0042586,GO:0043170,GO:0043412,GO:0043686,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:1901564	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	Pep_deformylase
HKD2_k127_6940806_0	485913.Krac_9086	7.112e-134	436.0	COG0037@1|root,COG0037@2|Bacteria,2G6AD@200795|Chloroflexi	200795|Chloroflexi	D	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine	tilS	-	2.4.2.8,6.3.4.19	ko:K00760,ko:K04075,ko:K15780	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	-	R00190,R01132,R01229,R02142,R08237,R08238,R08245,R09597	RC00063,RC00122,RC02633,RC02634	ko00000,ko00001,ko01000,ko03016	-	-	-	ATP_bind_3,Pribosyltran,TilS,TilS_C
HKD2_k127_6950894_1	485913.Krac_8483	2.083e-62	216.0	COG0820@1|root,COG0820@2|Bacteria,2G5SD@200795|Chloroflexi	200795|Chloroflexi	J	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs	rlmN	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140101,GO:0140102,GO:1901360	2.1.1.192	ko:K06941	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Radical_SAM
HKD2_k127_6950894_0	485913.Krac_8474	2.117e-104	350.0	COG0477@1|root,COG2814@2|Bacteria,2G8SG@200795|Chloroflexi	200795|Chloroflexi	EGP	PFAM major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD2_k127_6961343_0	485913.Krac_8881	2.667e-80	273.0	2DMUC@1|root,32TQR@2|Bacteria,2G6MF@200795|Chloroflexi	200795|Chloroflexi	S	CpXC protein	-	-	-	-	-	-	-	-	-	-	-	-	CpXC
HKD2_k127_6961343_1	1382306.JNIM01000001_gene3566	3.355e-73	249.0	COG0521@1|root,COG0521@2|Bacteria,2G7HV@200795|Chloroflexi	200795|Chloroflexi	H	Probable molybdopterin binding domain	-	-	-	-	-	-	-	-	-	-	-	-	MoCF_biosynth
HKD2_k127_6961343_2	1382306.JNIM01000001_gene3565	4.003e-72	250.0	COG2319@1|root,COG2319@2|Bacteria	2|Bacteria	S	anaphase-promoting complex binding	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos,NACHT,Pentapeptide,Pkinase,TIR_2,WD40
HKD2_k127_6991292_0	485913.Krac_11095	6.443e-206	646.0	COG4992@1|root,COG4992@2|Bacteria,2G5TW@200795|Chloroflexi	200795|Chloroflexi	E	TIGRFAM acetylornithine and succinylornithine aminotransferase	argD	-	2.6.1.11,2.6.1.17	ko:K00821	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
HKD2_k127_7002240_0	485913.Krac_8575	1.168e-187	593.0	COG0016@1|root,COG0016@2|Bacteria,2G5T1@200795|Chloroflexi	200795|Chloroflexi	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily	pheS	-	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Phe_tRNA-synt_N,tRNA-synt_2d
HKD2_k127_7008263_0	485913.Krac_6853	1.304e-263	821.0	COG0322@1|root,COG0847@1|root,COG0322@2|Bacteria,COG0847@2|Bacteria,2G7WZ@200795|Chloroflexi	200795|Chloroflexi	L	DNA polymerase III, epsilon subunit	-	-	2.7.7.7	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	GIY-YIG,RNase_T,UVR
HKD2_k127_7008263_1	485913.Krac_4618	5.111e-75	260.0	COG1011@1|root,COG1011@2|Bacteria,2G7B3@200795|Chloroflexi	200795|Chloroflexi	S	PFAM Haloacid dehalogenase domain protein hydrolase	-	-	3.8.1.2	ko:K01560	ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120	-	R05287	RC00697	ko00000,ko00001,ko01000	-	-	-	HAD_2
HKD2_k127_7024133_0	1382306.JNIM01000001_gene3762	1.729e-205	661.0	COG1287@1|root,COG1287@2|Bacteria,2G75T@200795|Chloroflexi	200795|Chloroflexi	S	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HKD2_k127_7024284_0	1123368.AUIS01000023_gene929	5.775e-121	391.0	COG0464@1|root,COG0464@2|Bacteria,1MUCN@1224|Proteobacteria,1RQPB@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	PFAM AAA ATPase central domain protein	-	-	-	ko:K06413	-	-	-	-	ko00000	-	-	-	AAA
HKD2_k127_7024284_1	485913.Krac_10713	4.31e-81	272.0	2DGVE@1|root,32U82@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7024284_2	485913.Krac_9626	8.227e-62	217.0	COG3039@1|root,COG3039@2|Bacteria,2G8AJ@200795|Chloroflexi	200795|Chloroflexi	L	SPTR B2JC10 Transposase IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_6,DUF772
HKD2_k127_7025909_2	485913.Krac_1216	6.329e-31	124.0	COG0642@1|root,COG2205@2|Bacteria,2G601@200795|Chloroflexi	200795|Chloroflexi	T	Osmosensitive K+ channel His kinase sensor domain	-	-	-	-	-	-	-	-	-	-	-	-	KdpD,Usp
HKD2_k127_7025909_1	485913.Krac_1222	6.517e-41	156.0	COG0745@1|root,COG0745@2|Bacteria,2G9SH@200795|Chloroflexi	485913.Krac_1222|-	T	SPTR D1CGX5 Response regulator receiver protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7025909_0	485913.Krac_9791	2.004e-186	593.0	COG0531@1|root,COG0531@2|Bacteria	2|Bacteria	E	amino acid	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7044016_1	485913.Krac_12541	1.065e-97	333.0	COG5002@1|root,COG5002@2|Bacteria,2G8A2@200795|Chloroflexi	2|Bacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	mtrB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464	2.7.13.3	ko:K02484,ko:K07642,ko:K07653,ko:K07654	ko02020,map02020	M00450,M00460,M00461,M00645,M00646,M00648	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
HKD2_k127_7044016_0	485913.Krac_12542	1.589e-167	551.0	COG1063@1|root,COG1063@2|Bacteria,2G7NV@200795|Chloroflexi	200795|Chloroflexi	C	Alcohol dehydrogenase GroES-like domain	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
HKD2_k127_7045460_0	485913.Krac_9977	2.242e-122	403.0	COG5650@1|root,COG5650@2|Bacteria	2|Bacteria	M	phosphatidylinositol metabolic process	-	-	-	-	-	-	-	-	-	-	-	-	GT87
HKD2_k127_7045460_1	485913.Krac_9976	2.905e-78	265.0	COG1225@1|root,COG1225@2|Bacteria,2G6XD@200795|Chloroflexi	200795|Chloroflexi	O	Redoxin	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
HKD2_k127_7046850_1	383372.Rcas_4052	9.414e-40	149.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1145@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1145@2|Bacteria,2G5M1@200795|Chloroflexi,376VN@32061|Chloroflexia	32061|Chloroflexia	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	-	-	1.2.7.1	ko:K03737	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00173,M00307	R01196,R10866	RC00004,RC02742	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	EKR,Fer4_16,PFOR_II,POR,POR_N,TPP_enzyme_C
HKD2_k127_7046850_0	357808.RoseRS_1785	1.113e-136	442.0	COG0167@1|root,COG0167@2|Bacteria,2G5T6@200795|Chloroflexi,3766V@32061|Chloroflexia	32061|Chloroflexia	F	Catalyzes the conversion of dihydroorotate to orotate	-	-	1.3.98.1	ko:K00226	ko00240,ko01100,map00240,map01100	M00051	R01867	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
HKD2_k127_7057338_2	1382356.JQMP01000003_gene1613	3.488e-73	249.0	COG0022@1|root,COG0022@2|Bacteria,2G84F@200795|Chloroflexi,27XW7@189775|Thermomicrobia	189775|Thermomicrobia	C	Transketolase, pyrimidine binding domain	-	-	-	ko:K21417	-	-	-	-	ko00000,ko01000	-	-	-	Transket_pyr,Transketolase_C
HKD2_k127_7057338_0	1382356.JQMP01000003_gene1612	7.548e-148	474.0	COG1071@1|root,COG1071@2|Bacteria,2G7RR@200795|Chloroflexi,27XJB@189775|Thermomicrobia	189775|Thermomicrobia	C	Dehydrogenase E1 component	-	-	-	ko:K21416	-	-	-	-	ko00000,ko01000	-	-	-	E1_dh
HKD2_k127_7057338_1	592015.HMPREF1705_00477	1.153e-85	295.0	COG0061@1|root,COG0061@2|Bacteria,3TC4U@508458|Synergistetes	508458|Synergistetes	H	ATP-NAD kinase	-	-	-	-	-	-	-	-	-	-	-	-	NAD_kinase
HKD2_k127_7079024_1	1382306.JNIM01000001_gene1454	2.527e-38	156.0	COG0438@1|root,COG0438@2|Bacteria,2G9IT@200795|Chloroflexi	200795|Chloroflexi	M	glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1,Glycos_transf_2
HKD2_k127_7079024_0	232721.Ajs_3009	7.801e-46	175.0	COG4464@1|root,COG4464@2|Bacteria,1R5E2@1224|Proteobacteria,2VS99@28216|Betaproteobacteria	28216|Betaproteobacteria	GM	capsular polysaccharide biosynthesis protein	-	-	3.1.3.48	ko:K01104	-	-	-	-	ko00000,ko01000	-	-	-	-
HKD2_k127_7079024_2	1382306.JNIM01000001_gene2933	8.269e-10	66.0	COG0451@1|root,COG0451@2|Bacteria,2G74B@200795|Chloroflexi	200795|Chloroflexi	GM	Protein of unknown function (DUF4012)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4012
HKD2_k127_7079680_0	485913.Krac_1569	2.834e-114	379.0	COG0514@1|root,COG0514@2|Bacteria,2G6QT@200795|Chloroflexi	200795|Chloroflexi	L	PFAM DEAD DEAH box helicase domain protein	-	-	3.6.4.12	ko:K03654	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecQ_Zn_bind
HKD2_k127_7079680_1	1869.MB27_18445	2.12e-49	186.0	COG0514@1|root,COG0514@2|Bacteria,2GJSS@201174|Actinobacteria,4D9V8@85008|Micromonosporales	201174|Actinobacteria	L	DNA helicase	-	-	3.6.4.12	ko:K03654	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,DUF3553,Helicase_C,RecQ_Zn_bind
HKD2_k127_7089556_0	485913.Krac_12036	2.881e-196	625.0	COG3428@1|root,COG3428@2|Bacteria	2|Bacteria	S	Bacterial PH domain	-	-	-	ko:K08981	-	-	-	-	ko00000	-	-	-	PASTA,bPH_2
HKD2_k127_7091142_0	290397.Adeh_3529	5.746e-59	220.0	COG0642@1|root,COG0784@1|root,COG2461@1|root,COG5002@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,COG2461@2|Bacteria,COG5002@2|Bacteria,1NRP8@1224|Proteobacteria,43CCU@68525|delta/epsilon subdivisions,2X7NQ@28221|Deltaproteobacteria,2YX99@29|Myxococcales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg
HKD2_k127_7091720_1	485913.Krac_3716	8.481e-70	239.0	COG0330@1|root,COG0330@2|Bacteria,2G5SB@200795|Chloroflexi	200795|Chloroflexi	O	PFAM band 7 protein	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
HKD2_k127_7091720_0	485913.Krac_9807	5.729e-74	258.0	COG1030@1|root,COG1030@2|Bacteria,2G6E2@200795|Chloroflexi	200795|Chloroflexi	O	NfeD-like C-terminal, partner-binding	-	-	-	ko:K07403	-	-	-	-	ko00000	-	-	-	CLP_protease,NfeD
HKD2_k127_7091720_2	485913.Krac_3369	6.981e-55	199.0	COG2124@1|root,COG2124@2|Bacteria,2G7UC@200795|Chloroflexi	200795|Chloroflexi	C	Cytochrome P450	-	-	-	-	-	-	-	-	-	-	-	-	p450
HKD2_k127_7101234_1	1382306.JNIM01000001_gene2543	1.77e-133	436.0	COG0515@1|root,COG0515@2|Bacteria	1382306.JNIM01000001_gene2543|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7101234_0	485913.Krac_6732	6.95e-144	457.0	COG0568@1|root,COG0568@2|Bacteria,2G5W3@200795|Chloroflexi	200795|Chloroflexi	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
HKD2_k127_7117697_0	485913.Krac_10161	5.615e-300	933.0	COG1506@1|root,COG1506@2|Bacteria,2G5Q5@200795|Chloroflexi	200795|Chloroflexi	EU	PFAM peptidase S9 prolyl oligopeptidase active site domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
HKD2_k127_7117697_1	485913.Krac_10164	4.732e-42	159.0	COG2189@1|root,COG2189@2|Bacteria,2G5WR@200795|Chloroflexi	200795|Chloroflexi	H	PFAM DNA methylase N-4 N-6 domain protein	-	-	2.1.1.72	ko:K00571,ko:K07316	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
HKD2_k127_7120011_1	479434.Sthe_0043	2.199e-91	304.0	COG0859@1|root,COG0859@2|Bacteria,2GBDN@200795|Chloroflexi,27YZF@189775|Thermomicrobia	189775|Thermomicrobia	M	Glycosyltransferase family 9 (heptosyltransferase)	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_9
HKD2_k127_7120011_0	479434.Sthe_0042	7.573e-163	529.0	COG0615@1|root,COG2870@1|root,COG0615@2|Bacteria,COG2870@2|Bacteria,2G87I@200795|Chloroflexi,27YW4@189775|Thermomicrobia	189775|Thermomicrobia	H	pfkB family carbohydrate kinase	-	-	2.7.1.167,2.7.7.70	ko:K03272	ko00540,ko01100,map00540,map01100	M00064	R05644,R05646	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	PfkB
HKD2_k127_7120011_2	479434.Sthe_0041	4.655e-78	267.0	COG0241@1|root,COG0241@2|Bacteria,2G6V8@200795|Chloroflexi,27Z4Y@189775|Thermomicrobia	189775|Thermomicrobia	E	Polynucleotide kinase 3 phosphatase	-	-	3.1.3.82,3.1.3.83	ko:K03273	ko00540,ko01100,map00540,map01100	M00064	R05647,R09771	RC00017	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hydrolase_like
HKD2_k127_7121393_0	485913.Krac_2619	9.117e-162	521.0	COG1502@1|root,COG1502@2|Bacteria,2G7KK@200795|Chloroflexi	200795|Chloroflexi	I	PFAM phospholipase D Transphosphatidylase	-	-	-	-	-	-	-	-	-	-	-	-	PLDc_2
HKD2_k127_7121393_1	485913.Krac_3149	2.593e-83	282.0	COG1961@1|root,COG1961@2|Bacteria	2|Bacteria	L	recombinase activity	-	-	-	-	-	-	-	-	-	-	-	-	Resolvase
HKD2_k127_7121393_3	1391646.AVSU01000061_gene1042	4.342e-05	47.0	COG1961@1|root,COG1961@2|Bacteria,1TQAX@1239|Firmicutes,24B05@186801|Clostridia,25TV5@186804|Peptostreptococcaceae	186801|Clostridia	L	Resolvase, N terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Resolvase
HKD2_k127_7121393_2	1382306.JNIM01000001_gene804	2.834e-38	147.0	COG1192@1|root,COG1192@2|Bacteria	2|Bacteria	D	plasmid maintenance	soj	GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0008150,GO:0009295,GO:0016020,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044424,GO:0044464,GO:0071944	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
HKD2_k127_7133466_0	485913.Krac_12314	4.963e-311	962.0	COG0449@1|root,COG0449@2|Bacteria,2G5T5@200795|Chloroflexi	200795|Chloroflexi	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
HKD2_k127_7133466_1	1123276.KB893246_gene854	1.32e-11	70.0	COG3385@1|root,COG3385@2|Bacteria,4P02Y@976|Bacteroidetes,47TUA@768503|Cytophagia	976|Bacteroidetes	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
HKD2_k127_7135879_1	485913.Krac_9796	1.727e-123	398.0	COG0410@1|root,COG0410@2|Bacteria,2G69M@200795|Chloroflexi	200795|Chloroflexi	E	PFAM ABC transporter related	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
HKD2_k127_7135879_2	485913.Krac_9797	5.416e-123	400.0	COG0411@1|root,COG0411@2|Bacteria,2G5W6@200795|Chloroflexi	200795|Chloroflexi	E	PFAM ABC transporter related	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
HKD2_k127_7135879_0	485913.Krac_9798	1.654e-256	806.0	COG4177@1|root,COG4177@2|Bacteria,2G6D8@200795|Chloroflexi	200795|Chloroflexi	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HKD2_k127_7135879_4	1382306.JNIM01000001_gene1702	4.731e-90	303.0	COG0559@1|root,COG0559@2|Bacteria,2G6FM@200795|Chloroflexi	200795|Chloroflexi	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HKD2_k127_7136897_0	485913.Krac_8830	5.032e-147	470.0	COG0154@1|root,COG0154@2|Bacteria,2G7S4@200795|Chloroflexi	200795|Chloroflexi	J	Belongs to the amidase family	-	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
HKD2_k127_7136897_1	1382306.JNIM01000001_gene79	3.166e-99	338.0	COG2518@1|root,COG2518@2|Bacteria,2G6NG@200795|Chloroflexi	2|Bacteria	J	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	-	-	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
HKD2_k127_7147378_2	485913.Krac_5826	1.24e-20	98.0	COG0265@1|root,COG0265@2|Bacteria,2G6KV@200795|Chloroflexi	200795|Chloroflexi	O	PFAM peptidase S1 and S6, chymotrypsin Hap	-	-	1.3.1.74	ko:K08070	-	-	-	-	ko00000,ko01000	-	-	-	PDZ_2,Trypsin_2
HKD2_k127_7147378_0	485913.Krac_10791	1.241e-183	580.0	COG4012@1|root,COG4012@2|Bacteria,2G6IF@200795|Chloroflexi	200795|Chloroflexi	S	Putative pyruvate format-lyase activating enzyme (DUF1786)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1786
HKD2_k127_7147378_1	485913.Krac_10789	2.754e-33	133.0	COG3255@1|root,COG3255@2|Bacteria,2G7E8@200795|Chloroflexi	200795|Chloroflexi	I	SCP-2 sterol transfer family	-	-	-	-	-	-	-	-	-	-	-	-	SCP2
HKD2_k127_7149622_0	1382306.JNIM01000001_gene704	4.14e-95	326.0	2DQ2F@1|root,334G7@2|Bacteria,2G92Q@200795|Chloroflexi	200795|Chloroflexi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7150004_1	383372.Rcas_0649	3.794e-65	229.0	COG2109@1|root,COG2109@2|Bacteria,2G6Q6@200795|Chloroflexi,375GV@32061|Chloroflexia	32061|Chloroflexia	H	PFAM ATP corrinoid adenosyltransferase BtuR CobO CobP	-	-	2.5.1.17	ko:K19221	ko00860,ko01100,map00860,map01100	M00122	R01492,R05220,R07268	RC00533	ko00000,ko00001,ko00002,ko01000	-	-	-	CobA_CobO_BtuR
HKD2_k127_7150004_0	1128421.JAGA01000002_gene290	3.634e-290	913.0	COG1429@1|root,COG1429@2|Bacteria	2|Bacteria	H	ligase activity, forming nitrogen-metal bonds	cobN	-	6.6.1.2	ko:K02230	ko00860,ko01100,map00860,map01100	-	R05227	RC02000	ko00000,ko00001,ko01000	-	-	iNJ661.Rv2062c	CobN-Mg_chel
HKD2_k127_7153924_0	485913.Krac_9972	2.702e-149	496.0	COG0515@1|root,COG0515@2|Bacteria,2G7ZS@200795|Chloroflexi	485913.Krac_9972|-	KLT	Serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7153924_1	485913.Krac_9974	1.635e-143	462.0	COG0715@1|root,COG0715@2|Bacteria,2G6E9@200795|Chloroflexi	200795|Chloroflexi	P	PFAM NMT1 THI5 like domain protein	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
HKD2_k127_7153924_3	485913.Krac_9975	2.796e-95	319.0	COG0600@1|root,COG0600@2|Bacteria,2G6HW@200795|Chloroflexi	200795|Chloroflexi	P	PFAM binding-protein-dependent transport systems inner membrane component	-	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
HKD2_k127_7153924_2	485913.Krac_9956	5.19e-99	328.0	COG2120@1|root,COG2120@2|Bacteria	2|Bacteria	S	N-acetylglucosaminylinositol deacetylase activity	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
HKD2_k127_7153924_4	485913.Krac_0978	9.739e-46	169.0	COG2259@1|root,COG2259@2|Bacteria,2G9AD@200795|Chloroflexi	200795|Chloroflexi	S	DoxX	-	-	-	-	-	-	-	-	-	-	-	-	DoxX
HKD2_k127_7153924_5	485913.Krac_0979	4.586e-32	127.0	COG1478@1|root,COG1478@2|Bacteria,2G5TU@200795|Chloroflexi	200795|Chloroflexi	S	TIGRFAM F420-dependent oxidoreductase	-	-	6.3.2.31,6.3.2.34	ko:K12234	ko00680,ko01120,map00680,map01120	M00378	R09399,R09400	RC00064,RC00090,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_ligase
HKD2_k127_7167197_0	485913.Krac_8332	1.094e-188	609.0	COG3372@1|root,COG3372@2|Bacteria,2G9BS@200795|Chloroflexi	200795|Chloroflexi	S	Protein of unknown function (DUF790)	-	-	-	ko:K09744	-	-	-	-	ko00000	-	-	-	DUF790
HKD2_k127_7167197_3	1122915.AUGY01000011_gene4059	5.494e-49	176.0	COG2140@1|root,COG2140@2|Bacteria,1TPC2@1239|Firmicutes,4HA6V@91061|Bacilli,26QUN@186822|Paenibacillaceae	91061|Bacilli	G	Oxalate decarboxylase	oxdD	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0008150,GO:0008152,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0019752,GO:0033609,GO:0043436,GO:0043648,GO:0044237,GO:0044281,GO:0044424,GO:0044464,GO:0046564,GO:0071704	4.1.1.2	ko:K01569	ko00630,ko01100,map00630,map01100	-	R00522	RC00321	ko00000,ko00001,ko01000	-	-	iYO844.BSU18670	Cupin_1
HKD2_k127_7167197_1	485913.Krac_3411	3.341e-141	453.0	COG2140@1|root,COG2140@2|Bacteria	2|Bacteria	G	oxalate decarboxylase activity	oxdC	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0008150,GO:0008152,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0019752,GO:0033609,GO:0043436,GO:0043648,GO:0044237,GO:0044281,GO:0044424,GO:0044464,GO:0046564,GO:0071704	4.1.1.2	ko:K01569	ko00630,ko01100,map00630,map01100	-	R00522	RC00321	ko00000,ko00001,ko01000	-	-	iYO844.BSU18670	Cupin_1
HKD2_k127_7167197_2	485913.Krac_8333	5.69e-105	355.0	COG0515@1|root,COG0515@2|Bacteria	485913.Krac_8333|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_716848_0	1382306.JNIM01000001_gene18	6.879e-100	334.0	COG2813@1|root,COG2813@2|Bacteria,2G8Y4@200795|Chloroflexi	200795|Chloroflexi	J	Methyltransferase small domain	-	-	-	-	-	-	-	-	-	-	-	-	MTS
HKD2_k127_716848_1	1382306.JNIM01000001_gene17	1.965e-52	190.0	COG0176@1|root,COG0176@2|Bacteria	2|Bacteria	G	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway	tal	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0016829,GO:0016830,GO:0016832,GO:0044424,GO:0044464,GO:0097023	2.2.1.2	ko:K00616,ko:K08313,ko:K08314	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	iB21_1397.B21_03781,iEC042_1314.EC042_0914,iECBD_1354.ECBD_4077,iECB_1328.ECB_03832,iECD_1391.ECD_03832,iECH74115_1262.ECH74115_5407,iECSP_1301.ECSP_5016,iECs_1301.ECs4875,iEcHS_1320.EcHS_A4181,iG2583_1286.G2583_4758,iSBO_1134.SBO_0715,iSF_1195.SF0775,iSFxv_1172.SFxv_0845,iS_1188.S0818,iZ_1308.Z5501	TAL_FSA
HKD2_k127_7171045_5	485913.Krac_8264	1.082e-27	116.0	COG0268@1|root,COG0268@2|Bacteria,2G7AK@200795|Chloroflexi	200795|Chloroflexi	J	Binds directly to 16S ribosomal RNA	rpsT	-	-	ko:K02968	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S20p
HKD2_k127_7171045_3	485913.Krac_8265	3.464e-69	239.0	COG0335@1|root,COG0335@2|Bacteria,2G6W0@200795|Chloroflexi	200795|Chloroflexi	J	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site	rplS	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02884	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L19
HKD2_k127_7171045_2	485913.Krac_8266	3.351e-88	296.0	COG0164@1|root,COG0164@2|Bacteria,2G6KR@200795|Chloroflexi	200795|Chloroflexi	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhB	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576	3.1.26.4	ko:K03470	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_HII
HKD2_k127_7171045_0	485913.Krac_8271	3.533e-114	373.0	COG0566@1|root,COG0566@2|Bacteria,2G6FR@200795|Chloroflexi	200795|Chloroflexi	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family	-	-	2.1.1.185	ko:K03218	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SpoU_methylase,SpoU_sub_bind
HKD2_k127_7171045_1	485913.Krac_8275	2.813e-101	334.0	COG0300@1|root,COG0300@2|Bacteria,2G7XW@200795|Chloroflexi	200795|Chloroflexi	S	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HKD2_k127_718288_0	383372.Rcas_3069	5.316e-48	188.0	COG1752@1|root,COG1752@2|Bacteria	2|Bacteria	M	Esterase of the alpha-beta hydrolase superfamily	suhR	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Patatin
HKD2_k127_7183645_0	485913.Krac_4380	2.476e-37	143.0	COG0204@1|root,COG0204@2|Bacteria,2G78P@200795|Chloroflexi	200795|Chloroflexi	I	PFAM phospholipid glycerol acyltransferase	-	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
HKD2_k127_7188305_0	1123368.AUIS01000005_gene433	4.043e-83	286.0	COG2116@1|root,COG2116@2|Bacteria,1N8YM@1224|Proteobacteria,1RPJ0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Formate nitrite	yfdC	GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0006855,GO:0008028,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015238,GO:0015318,GO:0015499,GO:0015711,GO:0015718,GO:0015724,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0042221,GO:0042493,GO:0042891,GO:0042895,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098656,GO:1903825,GO:1905039	-	ko:K21990	-	-	-	-	ko00000	1.A.16.4	-	-	Form_Nir_trans
HKD2_k127_7188305_1	485913.Krac_8856	1.119e-16	80.0	COG1670@1|root,COG1670@2|Bacteria	2|Bacteria	J	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins	p20	-	2.3.1.128	ko:K03790	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_3
HKD2_k127_7193659_0	485913.Krac_1367	4.278e-136	440.0	COG0614@1|root,COG0614@2|Bacteria,2G6EF@200795|Chloroflexi	200795|Chloroflexi	P	PFAM periplasmic binding protein	-	-	-	ko:K02016	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	Peripla_BP_2,TP_methylase
HKD2_k127_7193659_1	485913.Krac_10081	2.452e-12	69.0	COG0762@1|root,COG0762@2|Bacteria,2G9JK@200795|Chloroflexi	200795|Chloroflexi	S	integral membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	YGGT
HKD2_k127_7193659_2	485913.Krac_9699	2.891e-08	54.0	COG3415@1|root,COG3415@2|Bacteria	2|Bacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_ISAZ013,HTH_Tnp_4
HKD2_k127_7196715_0	485913.Krac_11337	1.048e-174	553.0	COG0444@1|root,COG0444@2|Bacteria,2G61B@200795|Chloroflexi	200795|Chloroflexi	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031,ko:K15583	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
HKD2_k127_7196715_1	485913.Krac_11336	4.699e-120	392.0	COG1173@1|root,COG1173@2|Bacteria,2G63I@200795|Chloroflexi	200795|Chloroflexi	EP	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
HKD2_k127_7204221_1	485913.Krac_9081	1.876e-67	235.0	COG3023@1|root,COG3023@2|Bacteria	2|Bacteria	V	N-Acetylmuramoyl-L-alanine amidase	-	-	3.2.1.52,3.5.1.28	ko:K01207,ko:K01447,ko:K11066	ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501	M00628	R00022,R04112,R05963,R07809,R07810,R10831	RC00049,RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011	-	-	-	Amidase_2,PG_binding_1
HKD2_k127_7204221_3	1128398.Curi_c07920	3.721e-09	66.0	COG4242@1|root,COG4242@2|Bacteria,1TSFA@1239|Firmicutes,249S4@186801|Clostridia,26AAS@186813|unclassified Clostridiales	186801|Clostridia	PQ	Peptidase family S51	cphB	-	3.4.15.6	ko:K13282	-	-	R09722	RC00064,RC00141	ko00000,ko01000,ko01002	-	-	-	Peptidase_S51
HKD2_k127_7204221_0	1120950.KB892711_gene2482	1.035e-70	250.0	COG0657@1|root,COG0657@2|Bacteria,2GNKU@201174|Actinobacteria	201174|Actinobacteria	I	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3
HKD2_k127_7204221_2	62928.azo3052	1.458e-24	104.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2VJJS@28216|Betaproteobacteria,2KY7V@206389|Rhodocyclales	206389|Rhodocyclales	I	AMP-binding enzyme C-terminal domain	-	-	6.2.1.25	ko:K04110	ko00362,ko00627,ko01100,ko01120,map00362,map00627,map01100,map01120	-	R01422	RC00004,RC00174	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C
HKD2_k127_7206247_2	1382306.JNIM01000001_gene1871	2.021e-85	286.0	COG2897@1|root,COG2897@2|Bacteria,2G8GM@200795|Chloroflexi	200795|Chloroflexi	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
HKD2_k127_7206247_1	485913.Krac_0961	6.638e-90	299.0	28NSZ@1|root,2ZBRT@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7206247_0	485913.Krac_0962	7.443e-219	687.0	COG0515@1|root,COG0515@2|Bacteria,2G8CD@200795|Chloroflexi	200795|Chloroflexi	KLT	Inner membrane component of T3SS, cytoplasmic domain	-	-	-	-	-	-	-	-	-	-	-	-	FHA,Pkinase
HKD2_k127_7206247_3	5059.CADAFLAP00011309	9.137e-55	196.0	2F3V5@1|root,2T4UR@2759|Eukaryota,38YMU@33154|Opisthokonta,3PY8A@4751|Fungi,3RHB6@4890|Ascomycota,20N26@147545|Eurotiomycetes	4751|Fungi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7211607_0	485913.Krac_1169	4.683e-65	233.0	COG4974@1|root,COG4974@2|Bacteria	2|Bacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_1,Phage_integrase
HKD2_k127_7219311_3	1121354.AQUV01000001_gene1332	4.962e-05	53.0	COG3693@1|root,COG3693@2|Bacteria,2GN8V@201174|Actinobacteria	201174|Actinobacteria	G	Belongs to the glycosyl hydrolase 5 (cellulase A) family	-	-	-	-	-	-	-	-	-	-	-	-	Cellulase,Glyco_hydro_42
HKD2_k127_7219311_2	485913.Krac_1643	1.617e-08	55.0	COG3316@1|root,COG3316@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS240
HKD2_k127_7219311_1	485913.Krac_6882	6.49e-11	67.0	COG0582@1|root,COG0582@2|Bacteria,2G7XX@200795|Chloroflexi	200795|Chloroflexi	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_3,Phage_integrase
HKD2_k127_7219311_0	485913.Krac_8263	8.211e-204	638.0	COG0626@1|root,COG0626@2|Bacteria,2G5M2@200795|Chloroflexi	200795|Chloroflexi	E	PFAM Cys Met metabolism pyridoxal-phosphate-dependent protein	-	-	2.5.1.48,4.4.1.11	ko:K01739,ko:K01761	ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017	R00654,R00999,R01288,R02508,R03217,R03260,R04770,R04944,R04945,R04946	RC00020,RC00056,RC00069,RC00196,RC00348,RC00420,RC01209,RC01210,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000	-	-	-	Cys_Met_Meta_PP
HKD2_k127_7222753_2	1041522.MCOL_V206850	1.16e-31	129.0	COG0654@1|root,COG0654@2|Bacteria,2GKUZ@201174|Actinobacteria,237UV@1762|Mycobacteriaceae	201174|Actinobacteria	CH	FAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3
HKD2_k127_7222753_3	485913.Krac_6321	1.496e-22	98.0	COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria	2|Bacteria	L	Transposase	-	-	-	ko:K07494	-	-	-	-	ko00000	-	-	-	DDE_3,HTH_23,HTH_32,HTH_33
HKD2_k127_7222753_1	485913.Krac_9148	4.441e-32	128.0	COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria	2|Bacteria	L	Transposase	-	-	-	ko:K07494	-	-	-	-	ko00000	-	-	-	DDE_3,HTH_23,HTH_32,HTH_33
HKD2_k127_7222753_0	546414.Deide_17825	1.904e-94	318.0	COG1715@1|root,COG1715@2|Bacteria	2|Bacteria	V	Restriction endonuclease	mrr	-	-	ko:K07448	-	-	-	-	ko00000,ko02048	-	-	-	Mrr_N,Mrr_cat
HKD2_k127_7222753_4	1122602.ATXP01000021_gene139	4.785e-06	48.0	COG1961@1|root,COG1961@2|Bacteria,2I8HV@201174|Actinobacteria	201174|Actinobacteria	L	COG1961 Site-specific recombinases, DNA invertase Pin homologs	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
HKD2_k127_7226031_1	485913.Krac_2661	3.435e-68	239.0	COG1082@1|root,COG1082@2|Bacteria,2G8Q7@200795|Chloroflexi	200795|Chloroflexi	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
HKD2_k127_7226031_0	525904.Tter_0396	4.494e-91	304.0	COG2141@1|root,COG2141@2|Bacteria,2NQM2@2323|unclassified Bacteria	2|Bacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
HKD2_k127_7235528_0	485913.Krac_12340	1.543e-129	430.0	COG1807@1|root,COG1807@2|Bacteria	2|Bacteria	M	4-amino-4-deoxy-L-arabinose transferase activity	-	-	2.4.1.109	ko:K00728	ko00514,ko00515,ko01100,map00514,map00515,map01100	-	R04072,R07620,R11399	RC00005,RC00059,RC00397	ko00000,ko00001,ko01000,ko01003	-	GT39	-	PMT_2
HKD2_k127_7241207_1	1121920.AUAU01000019_gene2583	1.879e-05	54.0	2E0YU@1|root,32WF9@2|Bacteria,3Y7YV@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_6
HKD2_k127_7241207_0	485913.Krac_8056	1.29e-165	531.0	COG0726@1|root,COG0726@2|Bacteria,2G8HZ@200795|Chloroflexi	200795|Chloroflexi	G	Polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
HKD2_k127_7249637_3	748658.KB907313_gene2023	1.814e-16	85.0	COG1051@1|root,COG1051@2|Bacteria,1MWNH@1224|Proteobacteria,1S56W@1236|Gammaproteobacteria,1WYDD@135613|Chromatiales	135613|Chromatiales	F	pfam nudix	-	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX
HKD2_k127_7249637_0	485913.Krac_7551	8.233e-170	542.0	COG0626@1|root,COG0626@2|Bacteria,2G684@200795|Chloroflexi	200795|Chloroflexi	E	PFAM Cys Met metabolism	-	-	2.5.1.48,4.4.1.11	ko:K01739,ko:K01761	ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017	R00654,R00999,R01288,R02508,R03217,R03260,R04770,R04944,R04945,R04946	RC00020,RC00056,RC00069,RC00196,RC00348,RC00420,RC01209,RC01210,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000	-	-	-	Cys_Met_Meta_PP
HKD2_k127_7249637_2	485913.Krac_6293	6.47e-37	141.0	COG0640@1|root,COG0640@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	-	-	-	ko:K04096	-	-	-	-	ko00000	-	-	-	DNA_processg_A,HTH_20,HTH_5,Methyltransf_11
HKD2_k127_7260220_2	1382306.JNIM01000001_gene772	4.192e-68	237.0	COG0494@1|root,COG0494@2|Bacteria,2G7AT@200795|Chloroflexi	200795|Chloroflexi	L	PFAM NUDIX hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
HKD2_k127_7260220_1	485913.Krac_11272	1.912e-219	693.0	COG0539@1|root,COG0539@2|Bacteria,2G656@200795|Chloroflexi	200795|Chloroflexi	J	PFAM RNA binding S1 domain protein	-	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
HKD2_k127_7260220_0	485913.Krac_11273	0.0	1554.0	COG0542@1|root,COG0542@2|Bacteria,2G5RA@200795|Chloroflexi	200795|Chloroflexi	O	ATPase AAA-2 domain protein	-	-	-	ko:K03696	ko01100,map01100	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N,HTH_17,UVR
HKD2_k127_7260220_3	485913.Krac_11273	6.132e-08	53.0	COG0542@1|root,COG0542@2|Bacteria,2G5RA@200795|Chloroflexi	200795|Chloroflexi	O	ATPase AAA-2 domain protein	-	-	-	ko:K03696	ko01100,map01100	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N,HTH_17,UVR
HKD2_k127_7295124_1	485913.Krac_12576	9.623e-22	99.0	COG1807@1|root,COG1807@2|Bacteria,2G991@200795|Chloroflexi	200795|Chloroflexi	M	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7295124_0	485913.Krac_12120	3.821e-42	166.0	COG0438@1|root,COG1216@1|root,COG0438@2|Bacteria,COG1216@2|Bacteria,2G6R5@200795|Chloroflexi	200795|Chloroflexi	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HKD2_k127_7295124_2	485913.Krac_0167	1.273e-17	83.0	COG3415@1|root,COG3415@2|Bacteria,2G9PU@200795|Chloroflexi	2|Bacteria	L	InterPro IPR009057	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_29,HTH_32
HKD2_k127_7302159_0	485913.Krac_11887	4.475e-176	558.0	COG0372@1|root,COG0372@2|Bacteria,2G637@200795|Chloroflexi	200795|Chloroflexi	H	Belongs to the citrate synthase family	-	-	2.3.3.1,2.3.3.5	ko:K01647,ko:K01659	ko00020,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00640,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351,R00931	RC00004,RC00067,RC00406,RC02827	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
HKD2_k127_7303045_0	485913.Krac_6978	9.198e-60	225.0	COG0489@1|root,COG0489@2|Bacteria,2G5WM@200795|Chloroflexi	200795|Chloroflexi	DM	PFAM lipopolysaccharide biosynthesis protein	-	-	2.7.10.2	ko:K08253	-	-	-	-	ko00000,ko01000	-	-	-	CbiA,Wzz
HKD2_k127_7303045_1	485913.Krac_6978	3.315e-07	56.0	COG0489@1|root,COG0489@2|Bacteria,2G5WM@200795|Chloroflexi	200795|Chloroflexi	DM	PFAM lipopolysaccharide biosynthesis protein	-	-	2.7.10.2	ko:K08253	-	-	-	-	ko00000,ko01000	-	-	-	CbiA,Wzz
HKD2_k127_733100_0	485913.Krac_0953	8.71e-216	673.0	COG0296@1|root,COG0296@2|Bacteria,2G5IR@200795|Chloroflexi	200795|Chloroflexi	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position	glgB	-	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48
HKD2_k127_733100_2	485913.Krac_0954	4.152e-12	66.0	COG1611@1|root,COG1611@2|Bacteria,2G6IB@200795|Chloroflexi	200795|Chloroflexi	S	Belongs to the LOG family	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
HKD2_k127_733100_1	1499967.BAYZ01000195_gene3102	2.489e-39	153.0	COG0438@1|root,COG0438@2|Bacteria,2NQRB@2323|unclassified Bacteria	2|Bacteria	M	Glycosyl transferase 4-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
HKD2_k127_7334036_1	485913.Krac_7856	9.663e-16	79.0	COG0172@1|root,COG0172@2|Bacteria,2G5PD@200795|Chloroflexi	200795|Chloroflexi	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	-	-	-	-	-	-	-	-	-	-	-	-	tRNA-synt_2b
HKD2_k127_7334036_0	485913.Krac_7857	3.962e-49	179.0	COG2306@1|root,COG2306@2|Bacteria,2GBPB@200795|Chloroflexi	200795|Chloroflexi	S	Protein of unknown function (DUF402)	-	-	-	ko:K07586	-	-	-	-	ko00000	-	-	-	DUF402
HKD2_k127_7353069_3	485913.Krac_2045	6.825e-07	53.0	COG0672@1|root,COG0672@2|Bacteria,2G6P3@200795|Chloroflexi	200795|Chloroflexi	P	PFAM Iron permease FTR1	-	-	-	ko:K07243	-	-	-	-	ko00000,ko02000	2.A.108.1,2.A.108.2	-	-	FTR1
HKD2_k127_7353069_2	485913.Krac_11634	3.252e-22	98.0	COG5659@1|root,COG5659@2|Bacteria	2|Bacteria	L	transposition	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5
HKD2_k127_7353069_1	1121377.KB906411_gene455	5.554e-126	408.0	COG0596@1|root,COG0596@2|Bacteria	2|Bacteria	S	hydrolase activity, acting on ester bonds	yfhM	-	-	ko:K22369	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Abhydrolase_1
HKD2_k127_7353069_0	485913.Krac_0451	5.917e-288	893.0	COG0477@1|root,COG0477@2|Bacteria	2|Bacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,MFS_1
HKD2_k127_7353707_1	1499967.BAYZ01000177_gene5717	8.237e-14	80.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD2_k127_7353707_0	926560.KE387025_gene4053	3.899e-69	242.0	28J69@1|root,2Z921@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7359502_0	1382306.JNIM01000001_gene1118	1.277e-122	398.0	COG0491@1|root,COG0491@2|Bacteria,2G93C@200795|Chloroflexi	200795|Chloroflexi	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HKD2_k127_7359502_1	485913.Krac_2100	1.303e-111	367.0	COG0378@1|root,COG0378@2|Bacteria,2G66Z@200795|Chloroflexi	200795|Chloroflexi	KO	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG	ureG	-	-	ko:K03189	-	-	-	-	ko00000	-	-	-	cobW
HKD2_k127_7359502_2	1382306.JNIM01000001_gene3026	1.485e-28	115.0	COG0804@1|root,COG0804@2|Bacteria,2G63F@200795|Chloroflexi	200795|Chloroflexi	E	Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family	ureC	-	3.5.1.5	ko:K01428	ko00220,ko00230,ko00791,ko01100,ko01120,ko05120,map00220,map00230,map00791,map01100,map01120,map05120	-	R00131	RC02798,RC02806	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1,Urease_alpha
HKD2_k127_7365728_1	1382306.JNIM01000001_gene1552	1.492e-65	226.0	COG1586@1|root,COG1586@2|Bacteria	2|Bacteria	E	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine	speD	-	2.5.1.16,4.1.1.50	ko:K00797,ko:K01611	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	M00034,M00133	R00178,R01920,R02869,R08359	RC00021,RC00053,RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	AdoMet_dc,Spermine_synth
HKD2_k127_7365728_0	485913.Krac_7537	1.752e-122	394.0	COG1899@1|root,COG1899@2|Bacteria,2G9B5@200795|Chloroflexi	200795|Chloroflexi	O	Deoxyhypusine synthase	-	-	-	-	-	-	-	-	-	-	-	-	DS
HKD2_k127_737841_1	243164.DET1501	2.499e-22	102.0	COG0716@1|root,COG0716@2|Bacteria,2GAZ4@200795|Chloroflexi,34DME@301297|Dehalococcoidia	301297|Dehalococcoidia	C	Flavodoxin	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_737841_0	485913.Krac_7239	1.453e-55	207.0	COG0589@1|root,COG0589@2|Bacteria,2G768@200795|Chloroflexi	200795|Chloroflexi	T	Belongs to the universal stress protein A family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD2_k127_737841_2	1444310.JANV01000170_gene2398	8.339e-06	49.0	COG2197@1|root,COG2197@2|Bacteria,1TRXG@1239|Firmicutes,4HCCV@91061|Bacilli,1ZDBY@1386|Bacillus	91061|Bacilli	K	COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain	yhcZ	-	-	ko:K02479	-	-	-	-	ko00000,ko02022	-	-	-	GerE,Response_reg
HKD2_k127_7408064_0	485913.Krac_12272	3.629e-120	401.0	COG0457@1|root,COG0457@2|Bacteria	485913.Krac_12272|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_742973_5	485913.Krac_1702	3.473e-23	100.0	COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,2G5SW@200795|Chloroflexi	200795|Chloroflexi	H	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate	ribD	-	1.1.1.193,3.5.4.26	ko:K11752	ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024	M00125	R03458,R03459	RC00204,RC00933	ko00000,ko00001,ko00002,ko01000	-	-	-	RibD_C,dCMP_cyt_deam_1
HKD2_k127_742973_0	1382306.JNIM01000001_gene3278	1.636e-159	514.0	COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,2G63D@200795|Chloroflexi	200795|Chloroflexi	H	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate	ribBA	-	3.5.4.25,4.1.99.12	ko:K01497,ko:K14652	ko00740,ko00790,ko01100,ko01110,ko02024,map00740,map00790,map01100,map01110,map02024	M00125,M00840	R00425,R07281	RC00293,RC01792,RC01815,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	-	DHBP_synthase,GTP_cyclohydro2
HKD2_k127_742973_2	485913.Krac_2155	2.31e-54	197.0	COG0054@1|root,COG0054@2|Bacteria,2G6J4@200795|Chloroflexi	200795|Chloroflexi	H	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin	ribH	GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.78	ko:K00794	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R04457	RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	DMRL_synthase
HKD2_k127_742973_1	485913.Krac_2156	4.163e-74	256.0	COG0307@1|root,COG0307@2|Bacteria,2G6QG@200795|Chloroflexi	200795|Chloroflexi	H	riboflavin synthase, alpha subunit	-	-	2.5.1.9	ko:K00793	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00066	RC00958,RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	Lum_binding
HKD2_k127_742973_3	485913.Krac_12481	2.866e-53	189.0	COG0292@1|root,COG0292@2|Bacteria,2G6V4@200795|Chloroflexi	200795|Chloroflexi	J	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit	rplT	GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015934,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904	-	ko:K02887	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L20
HKD2_k127_7440270_1	485913.Krac_10775	9.499e-101	332.0	COG1321@1|root,COG1321@2|Bacteria,2G7DY@200795|Chloroflexi	200795|Chloroflexi	K	iron dependent repressor	-	-	-	ko:K03709	-	-	-	-	ko00000,ko03000	-	-	-	Fe_dep_repr_C,Fe_dep_repress,FeoA
HKD2_k127_7440270_0	485913.Krac_10774	1.438e-135	450.0	COG3307@1|root,COG3307@2|Bacteria,2G79D@200795|Chloroflexi	200795|Chloroflexi	M	O-Antigen ligase	-	-	-	-	-	-	-	-	-	-	-	-	Wzy_C
HKD2_k127_7440270_2	1380394.JADL01000002_gene1154	1.67e-48	183.0	COG0477@1|root,COG0477@2|Bacteria,1MWXZ@1224|Proteobacteria,2TT27@28211|Alphaproteobacteria,2JSZ8@204441|Rhodospirillales	204441|Rhodospirillales	EGP	Major Facilitator Superfamily	-	-	-	ko:K08167	-	M00713,M00714	-	-	ko00000,ko00002,ko01504,ko02000	2.A.1.3	-	-	MFS_1
HKD2_k127_7446549_0	485913.Krac_8576	9.499e-263	818.0	COG0072@1|root,COG0072@2|Bacteria,2G5QR@200795|Chloroflexi	200795|Chloroflexi	J	phenylalanyl-tRNA synthetase beta subunit	pheT	-	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,tRNA_bind
HKD2_k127_7462307_0	485913.Krac_8343	4.729e-134	431.0	COG1131@1|root,COG1131@2|Bacteria,2G6KA@200795|Chloroflexi	200795|Chloroflexi	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD2_k127_7473489_4	1382306.JNIM01000001_gene2548	4.044e-68	246.0	COG0642@1|root,COG2205@2|Bacteria,2G8UJ@200795|Chloroflexi	200795|Chloroflexi	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HATPase_c,HisKA
HKD2_k127_7473489_0	485913.Krac_7874	7.537e-109	361.0	COG0803@1|root,COG0803@2|Bacteria,2G6XK@200795|Chloroflexi	200795|Chloroflexi	P	Zinc-uptake complex component A periplasmic	-	-	-	ko:K09818	-	M00243	-	-	ko00000,ko00002,ko02000	3.A.1.15	-	-	ZnuA
HKD2_k127_7473489_2	485913.Krac_6693	6.626e-106	350.0	COG1121@1|root,COG1121@2|Bacteria,2G5WQ@200795|Chloroflexi	200795|Chloroflexi	P	PFAM ABC transporter related	-	-	-	ko:K09817	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	ABC_tran
HKD2_k127_7473489_1	1382306.JNIM01000001_gene3441	2.785e-108	358.0	COG1108@1|root,COG1108@2|Bacteria,2G6GH@200795|Chloroflexi	200795|Chloroflexi	P	PFAM ABC-3 protein	-	-	-	ko:K09816,ko:K09819	ko02010,map02010	M00242,M00243	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15,3.A.1.15.3,3.A.1.15.5	-	-	ABC-3
HKD2_k127_7473489_3	1382306.JNIM01000001_gene3442	4.988e-94	316.0	COG1108@1|root,COG1108@2|Bacteria,2G6GH@200795|Chloroflexi	200795|Chloroflexi	P	PFAM ABC-3 protein	-	-	-	ko:K09816,ko:K09819	ko02010,map02010	M00242,M00243	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15,3.A.1.15.3,3.A.1.15.5	-	-	ABC-3
HKD2_k127_7473489_5	485913.Krac_3460	2.829e-28	117.0	COG0628@1|root,COG0628@2|Bacteria,2G6TV@200795|Chloroflexi	200795|Chloroflexi	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
HKD2_k127_7475574_0	485913.Krac_8519	3.805e-137	446.0	COG1466@1|root,COG1466@2|Bacteria,2G6XX@200795|Chloroflexi	200795|Chloroflexi	L	TIGRFAM DNA polymerase III, delta' subunit	holA	-	2.7.7.7	ko:K02340	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta
HKD2_k127_7501446_1	485913.Krac_8811	2.822e-165	529.0	COG0631@1|root,COG0631@2|Bacteria,2G8I1@200795|Chloroflexi	200795|Chloroflexi	T	Protein phosphatase 2C domain protein	-	-	3.1.3.16	ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C,PP2C_2
HKD2_k127_7501446_0	485913.Krac_8810	7.573e-230	715.0	COG2304@1|root,COG2304@2|Bacteria,2G82P@200795|Chloroflexi	200795|Chloroflexi	S	PFAM von Willebrand factor type A	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VWA
HKD2_k127_7501446_3	485913.Krac_8809	9.562e-96	318.0	COG1716@1|root,COG1716@2|Bacteria,2G8U3@200795|Chloroflexi	200795|Chloroflexi	T	PFAM Forkhead-associated protein	-	-	-	-	-	-	-	-	-	-	-	-	DZR,FHA
HKD2_k127_7501446_6	485913.Krac_8808	1.424e-15	77.0	COG0230@1|root,COG0230@2|Bacteria,2G7BX@200795|Chloroflexi	200795|Chloroflexi	J	Belongs to the bacterial ribosomal protein bL34 family	rpmH	-	-	ko:K02914	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L34
HKD2_k127_7501446_5	485913.Krac_8807	1.688e-29	121.0	COG0594@1|root,COG0594@2|Bacteria	2|Bacteria	J	ribonuclease P activity	rnpA	GO:0000966,GO:0001682,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005655,GO:0005730,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0030677,GO:0030681,GO:0031123,GO:0031404,GO:0031974,GO:0031981,GO:0032991,GO:0033204,GO:0034414,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0040007,GO:0042301,GO:0042779,GO:0042780,GO:0042781,GO:0043167,GO:0043168,GO:0043170,GO:0043199,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043628,GO:0044237,GO:0044238,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044452,GO:0044464,GO:0046483,GO:0070013,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0099116,GO:0140098,GO:0140101,GO:1901360,GO:1901363,GO:1901681,GO:1902494,GO:1902555,GO:1905267,GO:1905348,GO:1990904	3.1.26.5	ko:K03536,ko:K08998	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Ribonuclease_P
HKD2_k127_7501446_4	485913.Krac_8806	8.317e-39	145.0	COG0759@1|root,COG0759@2|Bacteria,2G76Q@200795|Chloroflexi	200795|Chloroflexi	S	Could be involved in insertion of integral membrane proteins into the membrane	-	-	-	ko:K08998	-	-	-	-	ko00000	-	-	-	Haemolytic
HKD2_k127_7501446_2	485913.Krac_8805	1.721e-103	346.0	COG0706@1|root,COG0706@2|Bacteria,2G6N0@200795|Chloroflexi	200795|Chloroflexi	U	PFAM 60 kDa inner membrane insertion protein	-	-	-	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03029	2.A.9	-	-	60KD_IMP
HKD2_k127_7502219_0	485913.Krac_9968	2.348e-141	456.0	COG0124@1|root,COG0124@2|Bacteria,2G6CX@200795|Chloroflexi	200795|Chloroflexi	J	PFAM tRNA synthetase class II (G H P and S)	hisZ	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
HKD2_k127_7515284_2	269797.Mbar_A0549	4.037e-53	191.0	COG1545@1|root,arCOG01285@2157|Archaea,2XXGF@28890|Euryarchaeota,2N9PT@224756|Methanomicrobia	224756|Methanomicrobia	V	DUF35 OB-fold domain, acyl-CoA-associated	-	-	-	ko:K07068	-	-	-	-	ko00000	-	-	-	DUF35_N,OB_aCoA_assoc
HKD2_k127_7515284_0	269797.Mbar_A0550	4.284e-164	524.0	COG0183@1|root,arCOG01278@2157|Archaea,2XT38@28890|Euryarchaeota,2N94P@224756|Methanomicrobia	224756|Methanomicrobia	I	PFAM Thiolase	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iAF692.Mbar_A0550	Thiolase_C,Thiolase_N
HKD2_k127_7515284_1	1094980.Mpsy_1638	1.461e-116	379.0	COG3425@1|root,arCOG01767@2157|Archaea,2XTWE@28890|Euryarchaeota,2N99Q@224756|Methanomicrobia	224756|Methanomicrobia	I	3-Oxoacyl- acyl-carrier-protein (ACP) synthase III C terminal	-	-	2.3.3.10	ko:K01641	ko00072,ko00280,ko00650,ko00900,ko01100,ko01110,ko01130,map00072,map00280,map00650,map00900,map01100,map01110,map01130	M00088,M00095	R01978	RC00004,RC00503	ko00000,ko00001,ko00002,ko01000	-	-	-	ACP_syn_III_C,HMG_CoA_synt_N
HKD2_k127_7517493_0	1382306.JNIM01000001_gene2829	5.976e-170	541.0	COG3367@1|root,COG3367@2|Bacteria	2|Bacteria	M	COGs COG3367 conserved	-	-	-	-	-	-	-	-	-	-	-	-	DUF1611,DUF1611_N,Peptidase_S8
HKD2_k127_7517493_1	266117.Rxyl_2026	5.713e-34	136.0	COG0220@1|root,COG0220@2|Bacteria,2GJ8R@201174|Actinobacteria	201174|Actinobacteria	J	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA	trmB	GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008176,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0034708,GO:0036265,GO:0040007,GO:0043170,GO:0043412,GO:0043414,GO:0043527,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0106004,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1990234	2.1.1.33	ko:K03439	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltransf_4
HKD2_k127_7526121_1	485913.Krac_10564	1.011e-71	249.0	290UJ@1|root,2ZNGJ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7526121_0	485913.Krac_10563	2.592e-99	330.0	COG0657@1|root,COG0657@2|Bacteria,2G8DI@200795|Chloroflexi	200795|Chloroflexi	I	alpha/beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6,Peptidase_S9
HKD2_k127_7526121_4	485913.Krac_10562	0.0002798	45.0	COG0846@1|root,COG0846@2|Bacteria,2G6QQ@200795|Chloroflexi	200795|Chloroflexi	K	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form	-	-	-	ko:K12410	-	-	-	-	ko00000,ko01000	-	-	-	SIR2
HKD2_k127_7526121_3	1382306.JNIM01000001_gene3729	9.228e-05	53.0	COG1470@1|root,COG1470@2|Bacteria	2|Bacteria	S	cell adhesion involved in biofilm formation	-	-	2.7.11.1	ko:K07004,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	ASH,DUF916,FHA,PG_binding_1,Pkinase
HKD2_k127_7526121_2	1382306.JNIM01000001_gene1018	7.06e-12	73.0	COG1470@1|root,COG1470@2|Bacteria	2|Bacteria	S	cell adhesion involved in biofilm formation	-	-	2.7.11.1	ko:K07004,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	ASH,DUF916,FHA,PG_binding_1,Pkinase
HKD2_k127_7537523_1	1382306.JNIM01000001_gene2596	2.37e-100	336.0	COG0730@1|root,COG0730@2|Bacteria	2|Bacteria	S	response to heat	MA20_18170	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
HKD2_k127_7537523_0	485913.Krac_2852	3.651e-203	638.0	COG2046@1|root,COG2046@2|Bacteria,2G7JD@200795|Chloroflexi	200795|Chloroflexi	H	Catalyzes the synthesis of activated sulfate	sat	-	2.7.7.4	ko:K00958	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00529,R04929	RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-sulfurylase,PUA_2
HKD2_k127_7537523_2	485913.Krac_2853	5.459e-93	308.0	COG0529@1|root,COG0529@2|Bacteria,2G8EW@200795|Chloroflexi	200795|Chloroflexi	P	Chromatin associated protein KTI12	-	-	-	-	-	-	-	-	-	-	-	-	APS_kinase
HKD2_k127_7539988_3	1123320.KB889664_gene1106	3.382e-100	342.0	COG1680@1|root,COG1680@2|Bacteria,2GIX5@201174|Actinobacteria	201174|Actinobacteria	V	Beta-lactamase	-	-	3.4.16.4	ko:K01286	-	-	-	-	ko00000,ko01000	-	-	-	Beta-lactamase
HKD2_k127_7539988_6	1382306.JNIM01000001_gene160	1.332e-68	237.0	COG1695@1|root,COG1695@2|Bacteria,2G7I0@200795|Chloroflexi	200795|Chloroflexi	K	PFAM transcriptional regulator PadR family protein	-	-	-	-	-	-	-	-	-	-	-	-	PadR,Vir_act_alpha_C
HKD2_k127_7539988_1	485913.Krac_8844	7.382e-131	432.0	COG2197@1|root,COG2197@2|Bacteria	2|Bacteria	K	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HKD2_k127_7539988_2	485913.Krac_8843	4.245e-102	341.0	COG1705@1|root,COG1705@2|Bacteria,2G8XA@200795|Chloroflexi	200795|Chloroflexi	NU	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase	-	-	-	-	-	-	-	-	-	-	-	-	Glucosaminidase
HKD2_k127_7539988_5	485913.Krac_8842	5.696e-85	285.0	COG0143@1|root,COG0143@2|Bacteria,2G6VG@200795|Chloroflexi	200795|Chloroflexi	J	Double zinc ribbon	-	-	-	-	-	-	-	-	-	-	-	-	DZR
HKD2_k127_7539988_0	485913.Krac_8841	0.0	1111.0	COG0187@1|root,COG0187@2|Bacteria,2G67C@200795|Chloroflexi	200795|Chloroflexi	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
HKD2_k127_7563583_4	485913.Krac_0960	3.293e-37	141.0	COG2897@1|root,COG2897@2|Bacteria,2G8GM@200795|Chloroflexi	200795|Chloroflexi	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
HKD2_k127_7563583_3	485913.Krac_3452	1.728e-38	147.0	COG0526@1|root,COG0526@2|Bacteria,2G7HX@200795|Chloroflexi	200795|Chloroflexi	CO	COG0526, thiol-disulfide isomerase and thioredoxins	-	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
HKD2_k127_7563583_1	1382306.JNIM01000001_gene1486	3.234e-101	336.0	COG0412@1|root,COG0412@2|Bacteria	2|Bacteria	Q	carboxymethylenebutenolidase activity	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
HKD2_k127_7563583_2	1382306.JNIM01000001_gene4197	6.325e-98	336.0	COG1397@1|root,COG1397@2|Bacteria	2|Bacteria	O	ADP-ribosylglycohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	ADP_ribosyl_GH,SseB
HKD2_k127_7574564_0	1121430.JMLG01000008_gene1569	3.032e-107	355.0	COG1239@1|root,COG1239@2|Bacteria,1UHYK@1239|Firmicutes,24BJ0@186801|Clostridia,2609Y@186807|Peptococcaceae	186801|Clostridia	H	PFAM magnesium chelatase	-	-	6.6.1.1	ko:K03404,ko:K03405	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R03877	RC01012	ko00000,ko00001,ko01000	-	-	-	AAA_5,Mg_chelatase,VWA_2
HKD2_k127_7574564_2	324602.Caur_2572	5.82e-66	245.0	COG2138@1|root,COG2138@2|Bacteria,2G7TZ@200795|Chloroflexi,375W8@32061|Chloroflexia	32061|Chloroflexia	S	PFAM cobalamin (vitamin B12) biosynthesis CbiX protein	-	-	4.99.1.3	ko:K03795	ko00860,ko01100,ko01120,map00860,map01100,map01120	-	R05807	RC01012	ko00000,ko00001,ko01000	-	-	-	CbiX
HKD2_k127_7574564_1	562970.Btus_0413	1.262e-67	236.0	COG1010@1|root,COG1010@2|Bacteria,1TPJ7@1239|Firmicutes,4HCQ1@91061|Bacilli,279A1@186823|Alicyclobacillaceae	91061|Bacilli	H	Tetrapyrrole (Corrin/Porphyrin) Methylases	cbiH	-	2.1.1.272	ko:K21479	ko00860,ko01100,map00860,map01100	-	R11580	RC03479	ko00000,ko00001,ko01000	-	-	-	NIR_SIR,TP_methylase
HKD2_k127_7612459_0	485913.Krac_7596	6.332e-263	833.0	COG1305@1|root,COG1305@2|Bacteria,2G66M@200795|Chloroflexi	200795|Chloroflexi	E	PFAM transglutaminase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF4129,Transglut_core
HKD2_k127_7612459_1	485913.Krac_7597	7.366e-196	616.0	COG1721@1|root,COG1721@2|Bacteria,2G5XH@200795|Chloroflexi	200795|Chloroflexi	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
HKD2_k127_7612459_2	485913.Krac_7598	2.246e-171	541.0	COG0714@1|root,COG0714@2|Bacteria,2G66D@200795|Chloroflexi	200795|Chloroflexi	S	ATPase associated with various cellular activities, AAA_3	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
HKD2_k127_7631837_0	485913.Krac_9225	1.781e-90	304.0	COG0406@1|root,COG0406@2|Bacteria,2G72Q@200795|Chloroflexi	200795|Chloroflexi	G	Phosphoglycerate mutase family	-	-	5.4.2.12	ko:K15634	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	His_Phos_1
HKD2_k127_7631837_1	946362.XP_004988747.1	1.657e-16	83.0	KOG0271@1|root,KOG0271@2759|Eukaryota,3AGU6@33154|Opisthokonta	33154|Opisthokonta	U	WD40 repeat-like protein	-	-	-	-	-	-	-	-	-	-	-	-	NACHT,NACHT_N,WD40
HKD2_k127_7638381_0	485913.Krac_9024	9.244e-166	527.0	COG0519@1|root,COG0519@2|Bacteria,2G5WB@200795|Chloroflexi	200795|Chloroflexi	F	Catalyzes the synthesis of GMP from XMP	guaA	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase,GMP_synt_C,NAD_synthase
HKD2_k127_7638381_2	1382306.JNIM01000001_gene3816	3.519e-35	136.0	COG1917@1|root,COG1917@2|Bacteria,2G9S4@200795|Chloroflexi	200795|Chloroflexi	S	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HKD2_k127_7638381_1	1382306.JNIM01000001_gene99	3.135e-71	247.0	COG1579@1|root,COG1579@2|Bacteria,2G775@200795|Chloroflexi	200795|Chloroflexi	S	Zn-ribbon protein possibly nucleic acid-binding	-	-	-	ko:K07164	-	-	-	-	ko00000	-	-	-	zf-RING_7
HKD2_k127_7663151_3	485913.Krac_8434	5.348e-24	103.0	COG1314@1|root,COG1314@2|Bacteria	2|Bacteria	U	P-P-bond-hydrolysis-driven protein transmembrane transporter activity	secG	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006605,GO:0006612,GO:0006613,GO:0006614,GO:0006616,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016043,GO:0022857,GO:0022884,GO:0031522,GO:0032978,GO:0032991,GO:0033036,GO:0033365,GO:0034613,GO:0042886,GO:0042887,GO:0043952,GO:0044464,GO:0045047,GO:0045184,GO:0046907,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061024,GO:0065002,GO:0070727,GO:0070972,GO:0071702,GO:0071705,GO:0071806,GO:0071840,GO:0071944,GO:0072594,GO:0072599,GO:0072657,GO:0090150,GO:1904680	-	ko:K03075	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecG
HKD2_k127_7663151_2	485913.Krac_8438	1.006e-103	340.0	COG2220@1|root,COG2220@2|Bacteria,2G6IQ@200795|Chloroflexi	200795|Chloroflexi	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_3
HKD2_k127_7663151_0	485913.Krac_8439	1.324e-309	954.0	COG0504@1|root,COG0504@2|Bacteria,2G5U0@200795|Chloroflexi	200795|Chloroflexi	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_synth_N,GATase
HKD2_k127_7663151_1	485913.Krac_8440	4.943e-112	371.0	COG2239@1|root,COG2239@2|Bacteria,2G6H7@200795|Chloroflexi	200795|Chloroflexi	P	Acts as a magnesium transporter	-	-	-	ko:K06213	-	-	-	-	ko00000,ko02000	1.A.26.1	-	-	CBS,MgtE,MgtE_N
HKD2_k127_7668098_1	562970.Btus_0413	1.779e-58	208.0	COG1010@1|root,COG1010@2|Bacteria,1TPJ7@1239|Firmicutes,4HCQ1@91061|Bacilli,279A1@186823|Alicyclobacillaceae	91061|Bacilli	H	Tetrapyrrole (Corrin/Porphyrin) Methylases	cbiH	-	2.1.1.272	ko:K21479	ko00860,ko01100,map00860,map01100	-	R11580	RC03479	ko00000,ko00001,ko01000	-	-	-	NIR_SIR,TP_methylase
HKD2_k127_7668098_0	1430331.EP10_11175	1.194e-71	256.0	COG2073@1|root,COG2073@2|Bacteria,1TPYM@1239|Firmicutes,4HAX7@91061|Bacilli,1WECX@129337|Geobacillus	91061|Bacilli	H	Cobalamin synthesis G C-terminus	cbiG	-	3.7.1.12	ko:K02189	ko00860,ko01100,map00860,map01100	-	R07772	RC01545,RC02097	ko00000,ko00001,ko01000	-	-	-	CbiG_C,CbiG_N,CbiG_mid
HKD2_k127_7668098_2	1382304.JNIL01000001_gene2505	5.291e-54	197.0	COG2875@1|root,COG2875@2|Bacteria,1TP6J@1239|Firmicutes,4HBN5@91061|Bacilli,279K2@186823|Alicyclobacillaceae	91061|Bacilli	H	Tetrapyrrole (Corrin/Porphyrin) Methylases	cbiF	-	2.1.1.133,2.1.1.271	ko:K05936	ko00860,ko01100,map00860,map01100	-	R05181,R05810	RC00003,RC01294,RC02049	ko00000,ko00001,ko01000	-	-	-	TP_methylase
HKD2_k127_7678292_0	485913.Krac_12030	1.324e-139	450.0	COG0445@1|root,COG0445@2|Bacteria,2G629@200795|Chloroflexi	200795|Chloroflexi	D	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34	gidA	GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363	-	ko:K03495	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko03016,ko03036	-	-	-	GIDA,GIDA_assoc
HKD2_k127_7691202_1	485913.Krac_3481	1.279e-09	62.0	COG5002@1|root,COG5002@2|Bacteria	2|Bacteria	T	protein histidine kinase activity	-	-	2.1.1.80,3.1.1.61	ko:K13924	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	DUF4118,GAF,HATPase_c,HisKA,PAS,PAS_4,PAS_9
HKD2_k127_7708435_0	1382306.JNIM01000001_gene3601	3.961e-198	627.0	COG0491@1|root,COG0607@1|root,COG0491@2|Bacteria,COG0607@2|Bacteria,2G5VX@200795|Chloroflexi	200795|Chloroflexi	P	PFAM beta-lactamase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
HKD2_k127_7708435_3	1382306.JNIM01000001_gene3895	9.751e-13	69.0	COG3476@1|root,COG3476@2|Bacteria	2|Bacteria	T	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)	crtK	-	-	ko:K05770	ko04080,ko04214,ko04979,ko05166,map04080,map04214,map04979,map05166	-	-	-	ko00000,ko00001,ko02000	9.A.24	-	-	TspO_MBR
HKD2_k127_7710572_1	1382306.JNIM01000001_gene438	3.193e-15	87.0	COG5305@1|root,COG5305@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HKD2_k127_7710572_0	1382306.JNIM01000001_gene438	2.358e-43	164.0	COG5305@1|root,COG5305@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HKD2_k127_7714784_0	485913.Krac_12128	1.037e-198	624.0	COG0305@1|root,COG0305@2|Bacteria,2G64D@200795|Chloroflexi	200795|Chloroflexi	L	Participates in initiation and elongation during chromosome replication	dnaB	-	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C
HKD2_k127_773284_1	1123508.JH636444_gene5358	2.296e-53	190.0	COG1233@1|root,COG1233@2|Bacteria	2|Bacteria	Q	all-trans-retinol 13,14-reductase activity	pys	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase,NAD_binding_8
HKD2_k127_773284_0	1382306.JNIM01000001_gene1160	1.033e-168	543.0	COG0260@1|root,COG0260@2|Bacteria,2G617@200795|Chloroflexi	200795|Chloroflexi	E	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	pepA	-	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17,Peptidase_M17_N
HKD2_k127_773348_0	1382306.JNIM01000001_gene2127	1.332e-217	679.0	COG1063@1|root,COG1063@2|Bacteria,2G7T9@200795|Chloroflexi	200795|Chloroflexi	C	PFAM Alcohol dehydrogenase GroES domain protein	-	-	1.2.1.46	ko:K00148	ko00625,ko00680,ko01100,ko01120,ko01200,map00625,map00680,map01100,map01120,map01200	-	R00604	RC00188	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_N_assoc,ADH_zinc_N
HKD2_k127_7749832_2	485913.Krac_7568	5.644e-81	282.0	COG0642@1|root,COG2205@2|Bacteria	485913.Krac_7568|-	T	PhoQ Sensor	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7749832_1	485913.Krac_7567	4.739e-111	362.0	COG0745@1|root,COG0745@2|Bacteria	485913.Krac_7567|-	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7749832_6	1382306.JNIM01000001_gene984	2.852e-46	178.0	COG2197@1|root,COG2197@2|Bacteria	2|Bacteria	K	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	Autoind_bind,GerE,HTH_18
HKD2_k127_7749832_3	485913.Krac_7565	6.382e-76	256.0	COG2199@1|root,COG3706@2|Bacteria	2|Bacteria	T	GGDEF domain	-	-	-	ko:K02657	ko02020,ko02025,map02020,map02025	M00507	-	-	ko00000,ko00001,ko00002,ko02022,ko02035,ko02044	-	-	-	EAL,GGDEF,Glyco_tranf_2_3,PAS_7,Response_reg
HKD2_k127_7749832_4	1382306.JNIM01000001_gene987	3.048e-63	220.0	COG0745@1|root,COG0745@2|Bacteria	1382306.JNIM01000001_gene987|-	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7749832_5	485913.Krac_7563	4.216e-55	199.0	COG0835@1|root,COG0835@2|Bacteria	2|Bacteria	NT	chemotaxis	cheW	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006935,GO:0008150,GO:0009605,GO:0019904,GO:0040011,GO:0042221,GO:0042330,GO:0044424,GO:0044444,GO:0044464,GO:0050896	-	ko:K03408	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheW
HKD2_k127_7750917_1	225937.HP15_3987	4.14e-56	198.0	COG0078@1|root,COG0078@2|Bacteria,1MUFM@1224|Proteobacteria,1RQ59@1236|Gammaproteobacteria,465TZ@72275|Alteromonadaceae	1236|Gammaproteobacteria	E	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline	argF	GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0033554,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0050896,GO:0051716,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.1.3.3,2.1.3.9	ko:K00611,ko:K09065	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01398,R07245	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	iAF1260.b0273,iECDH10B_1368.ECDH10B_0261,iECS88_1305.ECS88_4841,iJO1366.b0273,iJR904.b0273,iY75_1357.Y75_RS01410	OTCace,OTCace_N
HKD2_k127_7750917_0	485913.Krac_8342	3.189e-90	308.0	2BI26@1|root,32C73@2|Bacteria,2G8JF@200795|Chloroflexi	200795|Chloroflexi	-	-	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	-
HKD2_k127_7754577_1	1382306.JNIM01000001_gene3510	4.836e-67	235.0	COG0760@1|root,COG0760@2|Bacteria,2G6RV@200795|Chloroflexi	200795|Chloroflexi	O	PFAM PpiC-type peptidyl-prolyl cis-trans isomerase	-	-	-	-	-	-	-	-	-	-	-	-	Rotamase,Rotamase_3,SurA_N_3
HKD2_k127_7754577_0	485913.Krac_12488	3.651e-198	623.0	COG0635@1|root,COG0635@2|Bacteria,2G5NK@200795|Chloroflexi	200795|Chloroflexi	H	Involved in the biosynthesis of porphyrin-containing compound	hemN	-	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
HKD2_k127_7754577_2	1382306.JNIM01000001_gene3512	6.437e-07	54.0	COG0608@1|root,COG0608@2|Bacteria,2G5US@200795|Chloroflexi	200795|Chloroflexi	L	PFAM phosphoesterase, RecJ domain protein	recJ	-	-	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
HKD2_k127_7758710_1	485913.Krac_11263	1.332e-77	271.0	COG3429@1|root,COG3429@2|Bacteria,2G6ZV@200795|Chloroflexi	200795|Chloroflexi	G	Glucose-6-phosphate dehydrogenase subunit	-	-	-	-	-	-	-	-	-	-	-	-	OpcA_G6PD_assem
HKD2_k127_7758710_0	1382306.JNIM01000001_gene769	3.448e-95	318.0	COG0363@1|root,COG0363@2|Bacteria,2G6S0@200795|Chloroflexi	200795|Chloroflexi	G	PFAM glucosamine galactosamine-6-phosphate isomerase	-	-	3.1.1.31	ko:K01057	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200	M00004,M00006,M00008	R02035	RC00537	ko00000,ko00001,ko00002,ko01000	-	-	-	Glucosamine_iso
HKD2_k127_7758710_2	485913.Krac_11265	6.014e-62	217.0	COG0036@1|root,COG0036@2|Bacteria,2G6EU@200795|Chloroflexi	200795|Chloroflexi	G	Belongs to the ribulose-phosphate 3-epimerase family	rpe	-	5.1.3.1	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
HKD2_k127_7775271_0	1382306.JNIM01000001_gene256	4.432e-57	201.0	COG0251@1|root,COG0251@2|Bacteria,2G6XT@200795|Chloroflexi	200795|Chloroflexi	J	endoribonuclease L-PSP	-	-	3.5.99.10	ko:K09022	-	-	R11098,R11099	RC03275,RC03354	ko00000,ko01000	-	-	-	Ribonuc_L-PSP
HKD2_k127_7775271_1	1382306.JNIM01000001_gene257	1.139e-09	66.0	COG0593@1|root,COG0593@2|Bacteria,2G5W8@200795|Chloroflexi	200795|Chloroflexi	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids	dnaA	GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0034641,GO:0034645,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901576,GO:1990837	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA,Bac_DnaA_C,DnaA_N
HKD2_k127_7789088_0	586416.GZ22_07990	3.017e-160	513.0	COG0451@1|root,COG0451@2|Bacteria,1UC2P@1239|Firmicutes,4HB5E@91061|Bacilli	91061|Bacilli	GM	Dehydratase	-	-	3.13.1.1	ko:K06118	ko00520,ko00561,map00520,map00561	-	R05775	RC01469	ko00000,ko00001,ko01000	-	-	-	Epimerase
HKD2_k127_7789088_1	485913.Krac_0309	6.223e-91	316.0	COG1520@1|root,COG1520@2|Bacteria,2GBGD@200795|Chloroflexi	200795|Chloroflexi	S	PFAM Pyrrolo-quinoline quinone	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2,PQQ_3
HKD2_k127_7793089_0	485913.Krac_11301	5.143e-107	355.0	COG0206@1|root,COG0206@2|Bacteria,2G5V2@200795|Chloroflexi	200795|Chloroflexi	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsZ_C,Tubulin
HKD2_k127_7793089_2	485913.Krac_11304	4.809e-44	162.0	COG3729@1|root,COG3729@2|Bacteria	2|Bacteria	D	General stress protein	gsiB	-	-	ko:K06884	-	-	-	-	ko00000	-	-	-	AHH,KGG,LEA_5,YjzC
HKD2_k127_7793089_1	1382306.JNIM01000001_gene631	6.135e-88	292.0	COG1691@1|root,COG1691@2|Bacteria,2G6SZ@200795|Chloroflexi	200795|Chloroflexi	S	AIR carboxylase	-	-	-	ko:K06898	-	-	-	-	ko00000	-	-	-	AIRC
HKD2_k127_7795010_2	485913.Krac_12168	1.971e-73	251.0	COG0491@1|root,COG0491@2|Bacteria,2G8W8@200795|Chloroflexi	200795|Chloroflexi	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HKD2_k127_7795010_0	485913.Krac_12170	3.26e-128	416.0	COG0169@1|root,COG0169@2|Bacteria,2G6FG@200795|Chloroflexi	200795|Chloroflexi	E	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)	aroE	-	1.1.1.25	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413	RC00206	ko00000,ko00001,ko00002,ko01000	-	-	-	Shikimate_DH,Shikimate_dh_N
HKD2_k127_7795010_1	485913.Krac_12171	1.41e-78	267.0	COG0179@1|root,COG0179@2|Bacteria,2G6HH@200795|Chloroflexi	200795|Chloroflexi	Q	PFAM fumarylacetoacetate (FAA) hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	FAA_hydrolase
HKD2_k127_7795633_0	485913.Krac_7552	9.179e-115	378.0	COG2823@1|root,COG2823@2|Bacteria	2|Bacteria	S	hyperosmotic response	-	-	-	ko:K04065	-	-	-	-	ko00000	-	-	-	BON
HKD2_k127_78089_3	933262.AXAM01000022_gene3215	1.071e-16	81.0	COG1479@1|root,COG1479@2|Bacteria,1NRBC@1224|Proteobacteria,42VMR@68525|delta/epsilon subdivisions,2WSQN@28221|Deltaproteobacteria,2MMCV@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Protein of unknown function DUF262	-	-	-	-	-	-	-	-	-	-	-	-	DUF1524,DUF262
HKD2_k127_78089_1	485913.Krac_11765	9.695e-72	249.0	COG0778@1|root,COG0778@2|Bacteria,2G767@200795|Chloroflexi	200795|Chloroflexi	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	DUF2470,Nitroreductase
HKD2_k127_78089_0	485913.Krac_11766	1.09e-91	303.0	COG0503@1|root,COG0503@2|Bacteria,2G8K9@200795|Chloroflexi	200795|Chloroflexi	F	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis	apt	-	2.4.2.7	ko:K00759	ko00230,ko01100,map00230,map01100	-	R00190,R01229,R04378	RC00063	ko00000,ko00001,ko01000,ko04147	-	-	-	Pribosyltran
HKD2_k127_78089_2	525904.Tter_2027	7.684e-29	117.0	2A53P@1|root,31EH0@2|Bacteria,2NRNH@2323|unclassified Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7818677_2	485913.Krac_4630	1.018e-45	169.0	COG2084@1|root,COG2084@2|Bacteria,2G8J4@200795|Chloroflexi	200795|Chloroflexi	C	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_11,NAD_binding_2
HKD2_k127_7818677_1	485913.Krac_11004	2.408e-57	205.0	COG1514@1|root,COG1514@2|Bacteria,2G76S@200795|Chloroflexi	200795|Chloroflexi	J	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester	ligT	-	3.1.4.58	ko:K01975	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	LigT_PEase
HKD2_k127_7818677_0	485913.Krac_11009	3.729e-258	803.0	COG0465@1|root,COG0465@2|Bacteria,2G5J3@200795|Chloroflexi	200795|Chloroflexi	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	-	-	-	-	-	-	-	-	-	-	-	-	AAA,Peptidase_M41
HKD2_k127_7820203_1	1476583.DEIPH_ctg020orf0011	4.423e-73	252.0	COG0859@1|root,COG0859@2|Bacteria	2|Bacteria	M	ADP-heptose-lipopolysaccharide heptosyltransferase activity	rfaF	-	-	ko:K02843	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9
HKD2_k127_7820203_0	1173024.KI912148_gene3385	1.344e-113	375.0	COG2201@1|root,COG2201@2|Bacteria,1G3H5@1117|Cyanobacteria,1JHYJ@1189|Stigonemataceae	1117|Cyanobacteria	NT	CheB methylesterase	-	-	3.1.1.61,3.5.1.44	ko:K03412	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest
HKD2_k127_7820203_2	485913.Krac_12587	1.481e-09	60.0	COG1409@1|root,COG1409@2|Bacteria	2|Bacteria	S	acid phosphatase activity	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
HKD2_k127_7822825_2	765420.OSCT_2731	4.361e-39	151.0	COG1715@1|root,COG3587@1|root,COG1715@2|Bacteria,COG3587@2|Bacteria,2G7BW@200795|Chloroflexi,377W9@32061|Chloroflexia	32061|Chloroflexia	V	Restriction endonuclease	-	-	-	ko:K07448	-	-	-	-	ko00000,ko02048	-	-	-	Mrr_cat
HKD2_k127_7822825_0	1156937.MFUM_70009	8.536e-98	328.0	COG0572@1|root,COG0572@2|Bacteria,46WHT@74201|Verrucomicrobia,37H6V@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	F	Phosphoribulokinase / Uridine kinase family	udk	-	2.7.1.19	ko:K00855	ko00710,ko01100,ko01120,ko01200,map00710,map01100,map01120,map01200	M00165,M00166	R01523	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PRK
HKD2_k127_7822825_1	1382306.JNIM01000001_gene715	8.403e-60	218.0	COG0583@1|root,COG0583@2|Bacteria,2G70X@200795|Chloroflexi	200795|Chloroflexi	K	regulatory protein LysR	-	-	-	ko:K21703	-	-	-	-	ko00000,ko03000	-	-	-	HTH_1,LysR_substrate
HKD2_k127_7822825_3	768671.ThimaDRAFT_0078	5.764e-20	95.0	COG0583@1|root,COG0583@2|Bacteria,1MWVU@1224|Proteobacteria,1RPT8@1236|Gammaproteobacteria,1WWR6@135613|Chromatiales	135613|Chromatiales	K	Transcriptional regulator, LysR	-	-	-	ko:K21703	-	-	-	-	ko00000,ko03000	-	-	-	HTH_1,LysR_substrate
HKD2_k127_7823012_0	485913.Krac_12553	4.684e-183	580.0	COG0452@1|root,COG0452@2|Bacteria,2G60D@200795|Chloroflexi	200795|Chloroflexi	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	coaBC	-	4.1.1.36,6.3.2.5	ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	DFP,Flavoprotein
HKD2_k127_7823012_2	1382306.JNIM01000001_gene4092	6.492e-13	72.0	COG0842@1|root,COG1131@1|root,COG0842@2|Bacteria,COG1131@2|Bacteria,2G7J8@200795|Chloroflexi	200795|Chloroflexi	V	FHA modulated ABC efflux pump with fused ATPase and integral membrane subunits	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane,ABC_tran,FHA
HKD2_k127_7841049_1	1038862.KB893835_gene1944	3.757e-38	149.0	COG3509@1|root,COG3509@2|Bacteria,1MXUI@1224|Proteobacteria,2TUS5@28211|Alphaproteobacteria,3JRUS@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	Esterase PHB depolymerase	-	-	-	-	-	-	-	-	-	-	-	-	Esterase_phd
HKD2_k127_7841049_0	322710.Avin_33510	2.321e-53	190.0	COG3609@1|root,COG3609@2|Bacteria,1RHNZ@1224|Proteobacteria,1SN7Q@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	transcriptional regulators containing the CopG Arc MetJ DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7862937_1	485913.Krac_10210	1.989e-53	193.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	NHL
HKD2_k127_7862937_0	485913.Krac_8342	2.153e-66	237.0	2BI26@1|root,32C73@2|Bacteria,2G8JF@200795|Chloroflexi	200795|Chloroflexi	-	-	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	-
HKD2_k127_7885486_0	485913.Krac_8664	0.0	1078.0	COG0317@1|root,COG0317@2|Bacteria,2G67Y@200795|Chloroflexi	200795|Chloroflexi	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	relA	-	2.7.6.5	ko:K00951	ko00230,map00230	-	R00429	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
HKD2_k127_7887403_0	1541065.JRFE01000051_gene4944	2.567e-38	166.0	COG0728@1|root,COG0728@2|Bacteria,1G1YC@1117|Cyanobacteria,3VHRP@52604|Pleurocapsales	1117|Cyanobacteria	S	MviN-like protein	-	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
HKD2_k127_7889128_0	485913.Krac_1342	3.931e-146	471.0	COG2008@1|root,COG2008@2|Bacteria,2G5XG@200795|Chloroflexi	200795|Chloroflexi	E	aromatic amino acid beta-eliminating lyase threonine aldolase	gly1	-	4.1.2.48	ko:K01620	ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230	-	R00751,R06171	RC00312,RC00372	ko00000,ko00001,ko01000	-	-	-	Beta_elim_lyase
HKD2_k127_7889128_1	485913.Krac_4989	5.432e-51	182.0	COG0393@1|root,COG0393@2|Bacteria	2|Bacteria	S	Putative heavy-metal-binding	ybjQ	-	-	-	-	-	-	-	-	-	-	-	YbjQ_1
HKD2_k127_7900819_1	485913.Krac_9081	1.68e-54	202.0	COG3023@1|root,COG3023@2|Bacteria	2|Bacteria	V	N-Acetylmuramoyl-L-alanine amidase	-	-	3.2.1.52,3.5.1.28	ko:K01207,ko:K01447,ko:K11066	ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501	M00628	R00022,R04112,R05963,R07809,R07810,R10831	RC00049,RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011	-	-	-	Amidase_2,PG_binding_1
HKD2_k127_7900819_0	1382306.JNIM01000001_gene2445	5.079e-193	622.0	2EPXU@1|root,33HIC@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7922761_1	485913.Krac_8705	4.986e-07	53.0	COG0592@1|root,COG0592@2|Bacteria,2G641@200795|Chloroflexi	200795|Chloroflexi	L	Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria	dnaN	-	2.7.7.7	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3
HKD2_k127_7922761_0	1382306.JNIM01000001_gene3849	2.98e-98	334.0	COG0789@1|root,COG5012@1|root,COG0789@2|Bacteria,COG5012@2|Bacteria,2G6R8@200795|Chloroflexi	200795|Chloroflexi	K	PFAM regulatory protein, MerR	-	-	-	ko:K22491	-	-	-	-	ko00000,ko03000	-	-	-	B12-binding,B12-binding_2,MerR_1
HKD2_k127_7922785_1	485913.Krac_3687	6.505e-47	172.0	COG1846@1|root,COG1846@2|Bacteria,2G97N@200795|Chloroflexi	200795|Chloroflexi	K	Transcriptional regulator, MarR family	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7922785_0	1382306.JNIM01000001_gene1545	6.555e-119	392.0	COG2223@1|root,COG2223@2|Bacteria	2|Bacteria	P	nitrite transmembrane transporter activity	-	-	-	ko:K02575	ko00910,map00910	M00615	-	-	ko00000,ko00001,ko00002,ko02000	2.A.1.8	-	-	MFS_1
HKD2_k127_7932210_0	485913.Krac_2862	1.693e-93	314.0	COG1226@1|root,COG1226@2|Bacteria,2G7EI@200795|Chloroflexi	200795|Chloroflexi	P	PFAM TrkA-N domain protein	-	-	-	-	-	-	-	-	-	-	-	-	TrkA_C,TrkA_N
HKD2_k127_7932210_1	1382306.JNIM01000001_gene1913	1.561e-49	184.0	COG0589@1|root,COG0589@2|Bacteria	2|Bacteria	T	AMP binding	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD2_k127_7932210_2	1382306.JNIM01000001_gene1912	1.105e-32	128.0	COG1055@1|root,COG1055@2|Bacteria,2G69P@200795|Chloroflexi	200795|Chloroflexi	P	Arsenical pump membrane protein	-	-	-	ko:K03893	-	-	-	-	ko00000,ko02000	2.A.45.1,3.A.4.1	-	-	ArsB
HKD2_k127_7948755_3	1382306.JNIM01000001_gene256	4.343e-26	108.0	COG0251@1|root,COG0251@2|Bacteria,2G6XT@200795|Chloroflexi	200795|Chloroflexi	J	endoribonuclease L-PSP	-	-	3.5.99.10	ko:K09022	-	-	R11098,R11099	RC03275,RC03354	ko00000,ko01000	-	-	-	Ribonuc_L-PSP
HKD2_k127_7948755_0	485913.Krac_12329	1.759e-211	668.0	COG0593@1|root,COG0593@2|Bacteria,2G5W8@200795|Chloroflexi	200795|Chloroflexi	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids	dnaA	GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0034641,GO:0034645,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901576,GO:1990837	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA,Bac_DnaA_C,DnaA_N
HKD2_k127_7948755_2	485913.Krac_12327	1.866e-103	342.0	COG0647@1|root,COG0647@2|Bacteria,2G6QY@200795|Chloroflexi	200795|Chloroflexi	G	PFAM Haloacid dehalogenase domain protein hydrolase	-	-	-	ko:K02566	-	-	-	-	ko00000	-	-	-	Hydrolase_6,Hydrolase_like
HKD2_k127_7948755_1	485913.Krac_3098	2.324e-195	617.0	COG1116@1|root,COG4754@1|root,COG1116@2|Bacteria,COG4754@2|Bacteria,2G5P9@200795|Chloroflexi	200795|Chloroflexi	P	PFAM ABC transporter related	-	-	-	ko:K02049,ko:K15555,ko:K15578	ko00910,ko00920,ko02010,map00910,map00920,map02010	M00188,M00436,M00438	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.16,3.A.1.16.1,3.A.1.17,3.A.1.17.2	-	-	AAA_assoc_C,ABC_tran
HKD2_k127_7954791_0	1121889.AUDM01000002_gene369	2.913e-66	237.0	COG3408@1|root,COG3408@2|Bacteria,4NGZM@976|Bacteroidetes,1I02Y@117743|Flavobacteriia,2NTCE@237|Flavobacterium	976|Bacteroidetes	G	Alkaline and neutral invertase	-	-	-	-	-	-	-	-	-	-	-	-	GDE_C,Glyco_hydro_100,S6PP
HKD2_k127_7959449_0	1267534.KB906759_gene1792	6.218e-129	430.0	COG1053@1|root,COG1053@2|Bacteria	2|Bacteria	C	succinate dehydrogenase	sdhA	GO:0000104,GO:0000166,GO:0001539,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006091,GO:0006113,GO:0006928,GO:0006950,GO:0006974,GO:0006996,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016043,GO:0016491,GO:0016627,GO:0022607,GO:0022900,GO:0030030,GO:0030031,GO:0032991,GO:0033554,GO:0036094,GO:0040011,GO:0043167,GO:0043168,GO:0044085,GO:0044237,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0044780,GO:0044781,GO:0045273,GO:0045274,GO:0045283,GO:0045284,GO:0045333,GO:0048037,GO:0048870,GO:0050660,GO:0050662,GO:0050896,GO:0051179,GO:0051674,GO:0051716,GO:0055114,GO:0070469,GO:0070470,GO:0070925,GO:0071840,GO:0071944,GO:0071949,GO:0071973,GO:0097159,GO:0097588,GO:0098796,GO:0098797,GO:0098803,GO:1901265,GO:1901363	1.3.5.1,1.3.5.4	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
HKD2_k127_7959449_1	485913.Krac_10515	1.791e-98	323.0	COG0458@1|root,COG0458@2|Bacteria,2G5NX@200795|Chloroflexi	200795|Chloroflexi	F	Carbamoyl-phosphate synthetase large chain domain protein	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
HKD2_k127_7962776_1	1382306.JNIM01000001_gene3311	5.634e-75	253.0	COG0318@1|root,COG0318@2|Bacteria,2G5NE@200795|Chloroflexi	200795|Chloroflexi	IQ	AMP-binding enzyme C-terminal domain	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
HKD2_k127_7962776_2	485913.Krac_8147	2.921e-22	96.0	COG0318@1|root,COG0318@2|Bacteria,2G5NE@200795|Chloroflexi	200795|Chloroflexi	IQ	AMP-binding enzyme C-terminal domain	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
HKD2_k127_7962776_0	485913.Krac_11695	6.136e-211	660.0	COG2115@1|root,COG2115@2|Bacteria,2G688@200795|Chloroflexi	200795|Chloroflexi	G	PFAM Xylose isomerase domain protein TIM barrel	xylA	-	5.3.1.5	ko:K01805	ko00040,ko00051,ko01100,map00040,map00051,map01100	-	R00878,R01432	RC00376,RC00516	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
HKD2_k127_7994910_0	485913.Krac_5480	3.315e-92	306.0	COG2801@1|root,COG2801@2|Bacteria,2G9UE@200795|Chloroflexi	200795|Chloroflexi	L	HTH-like domain	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21
HKD2_k127_7994910_1	485913.Krac_5481	1.146e-39	150.0	COG2963@1|root,COG2963@2|Bacteria	2|Bacteria	L	transposase activity	-	-	-	ko:K07483,ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,HTH_Tnp_1,rve
HKD2_k127_8022823_4	485913.Krac_12521	3.951e-79	265.0	COG0197@1|root,COG0197@2|Bacteria,2G6NA@200795|Chloroflexi	200795|Chloroflexi	J	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs	rplP	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904	-	ko:K02878	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L16
HKD2_k127_8022823_10	485913.Krac_12519	6.757e-44	163.0	COG0186@1|root,COG0186@2|Bacteria,2G722@200795|Chloroflexi	200795|Chloroflexi	J	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA	rpsQ	-	-	ko:K02961	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17
HKD2_k127_8022823_7	485913.Krac_12518	4.618e-66	226.0	COG0093@1|root,COG0093@2|Bacteria,2G6MZ@200795|Chloroflexi	200795|Chloroflexi	J	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome	rplN	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0097159,GO:1901363,GO:1990904	-	ko:K02874	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L14
HKD2_k127_8022823_9	1382306.JNIM01000001_gene3538	5.495e-55	195.0	COG0198@1|root,COG0198@2|Bacteria,2G750@200795|Chloroflexi	200795|Chloroflexi	J	One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rplX	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02895	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KOW,ribosomal_L24
HKD2_k127_8022823_1	485913.Krac_12516	4.239e-94	310.0	COG0094@1|root,COG0094@2|Bacteria,2G6C6@200795|Chloroflexi	200795|Chloroflexi	J	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits	rplE	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02931	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L5,Ribosomal_L5_C
HKD2_k127_8022823_11	485913.Krac_12515	1.765e-29	117.0	COG0199@1|root,COG0199@2|Bacteria,2G74J@200795|Chloroflexi	200795|Chloroflexi	J	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site	rpsN	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02954	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S14
HKD2_k127_8022823_5	485913.Krac_12514	1.262e-72	245.0	COG0096@1|root,COG0096@2|Bacteria,2G6XS@200795|Chloroflexi	200795|Chloroflexi	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit	rpsH	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02994	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8
HKD2_k127_8022823_2	485913.Krac_12513	5.59e-92	304.0	COG0097@1|root,COG0097@2|Bacteria,2G6HZ@200795|Chloroflexi	200795|Chloroflexi	J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center	rplF	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02933	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L6
HKD2_k127_8022823_8	485913.Krac_12512	6.407e-60	212.0	COG0256@1|root,COG0256@2|Bacteria,2G6Y4@200795|Chloroflexi	200795|Chloroflexi	J	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance	rplR	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008097,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904	-	ko:K02881	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18p
HKD2_k127_8022823_0	485913.Krac_12511	2.806e-94	314.0	COG0098@1|root,COG0098@2|Bacteria,2G6M9@200795|Chloroflexi	200795|Chloroflexi	J	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body	rpsE	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02988	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S5,Ribosomal_S5_C
HKD2_k127_8022823_12	485913.Krac_12510	6.684e-20	90.0	COG1841@1|root,COG1841@2|Bacteria,2G7E7@200795|Chloroflexi	200795|Chloroflexi	J	Ribosomal protein L30	rpmD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02907	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L30
HKD2_k127_8022823_6	485913.Krac_12509	8.185e-70	240.0	COG0200@1|root,COG0200@2|Bacteria,2G6XY@200795|Chloroflexi	200795|Chloroflexi	J	Binds to the 23S rRNA	rplO	-	-	ko:K02876	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27A
HKD2_k127_8022823_3	485913.Krac_12508	4.874e-90	303.0	COG0201@1|root,COG0201@2|Bacteria,2G5X4@200795|Chloroflexi	200795|Chloroflexi	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	-	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	SecY
HKD2_k127_8024596_0	861299.J421_4006	5.38e-55	206.0	COG3266@1|root,COG3266@2|Bacteria,1ZT0N@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8031492_0	485913.Krac_10521	1.5e-323	1006.0	COG0793@1|root,COG4946@1|root,COG0793@2|Bacteria,COG4946@2|Bacteria,2G64C@200795|Chloroflexi	200795|Chloroflexi	M	Tricorn protease homolog	-	-	-	ko:K08676	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PD40,Peptidase_S41,Tricorn_C1,Tricorn_PDZ
HKD2_k127_8031492_3	225849.swp_2693	0.00073	44.0	COG3603@1|root,COG3603@2|Bacteria,1RI6G@1224|Proteobacteria,1S72Y@1236|Gammaproteobacteria,2QC0U@267890|Shewanellaceae	1236|Gammaproteobacteria	S	ACT domain	-	-	-	ko:K09707	-	-	-	-	ko00000	-	-	-	ACT_7
HKD2_k127_8031492_1	1123508.JH636440_gene2784	1.472e-66	233.0	COG3832@1|root,COG3832@2|Bacteria	2|Bacteria	J	glyoxalase III activity	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc,Polyketide_cyc2
HKD2_k127_8031492_2	485913.Krac_1354	2.303e-49	180.0	COG1396@1|root,COG1396@2|Bacteria	2|Bacteria	K	sequence-specific DNA binding	clgR	GO:0002682,GO:0002683,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006109,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0009266,GO:0009268,GO:0009408,GO:0009605,GO:0009607,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0009894,GO:0009987,GO:0010447,GO:0010468,GO:0010556,GO:0010557,GO:0010565,GO:0010604,GO:0010628,GO:0010675,GO:0019216,GO:0019217,GO:0019219,GO:0019222,GO:0022611,GO:0030162,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031329,GO:0031347,GO:0031348,GO:0032268,GO:0032502,GO:0033554,GO:0035821,GO:0040007,GO:0042176,GO:0043207,GO:0043565,GO:0043620,GO:0044003,GO:0044110,GO:0044111,GO:0044114,GO:0044115,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044413,GO:0044414,GO:0044419,GO:0045088,GO:0045824,GO:0045893,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048583,GO:0048585,GO:0050776,GO:0050777,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051246,GO:0051252,GO:0051254,GO:0051701,GO:0051704,GO:0051707,GO:0051716,GO:0051817,GO:0051832,GO:0051833,GO:0052031,GO:0052037,GO:0052167,GO:0052170,GO:0052173,GO:0052200,GO:0052255,GO:0052261,GO:0052306,GO:0052309,GO:0052552,GO:0052553,GO:0052561,GO:0052562,GO:0052564,GO:0052572,GO:0060255,GO:0061136,GO:0062012,GO:0065007,GO:0075136,GO:0080090,GO:0080134,GO:0085016,GO:0090062,GO:0097159,GO:1901363,GO:1902680,GO:1902882,GO:1903050,GO:1903362,GO:1903506,GO:1903508,GO:2000112,GO:2001141	-	-	-	-	-	-	-	-	-	-	HTH_3,HTH_31
HKD2_k127_8038272_3	105425.BBPL01000027_gene580	6.439e-24	103.0	COG2346@1|root,COG3369@1|root,COG3592@1|root,COG2346@2|Bacteria,COG3369@2|Bacteria,COG3592@2|Bacteria,2GMG5@201174|Actinobacteria,2NI62@228398|Streptacidiphilus	201174|Actinobacteria	S	Bacterial-like globin	-	-	-	ko:K06886	-	-	-	-	ko00000	-	-	-	Bac_globin,Fer4_19,zf-CDGSH
HKD2_k127_8038272_0	485913.Krac_8739	2.684e-183	582.0	COG0138@1|root,COG0138@2|Bacteria,2G5JG@200795|Chloroflexi	2|Bacteria	F	Bifunctional purine biosynthesis protein PurH	purH	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AICARFT_IMPCHas,MGS
HKD2_k127_8038272_2	1382306.JNIM01000001_gene3908	3.889e-28	121.0	COG4818@1|root,COG4818@2|Bacteria	2|Bacteria	S	TM2 domain	M1-746	-	-	-	-	-	-	-	-	-	-	-	DUF4870
HKD2_k127_8038272_6	1068978.AMETH_2846	0.0005787	45.0	COG1215@1|root,COG1215@2|Bacteria,2GP1D@201174|Actinobacteria,4DXVU@85010|Pseudonocardiales	201174|Actinobacteria	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HKD2_k127_8038272_1	485913.Krac_8159	2.597e-152	489.0	COG3173@1|root,COG3173@2|Bacteria,2G5RM@200795|Chloroflexi	200795|Chloroflexi	S	Phosphotransferase enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	APH
HKD2_k127_8046445_2	882082.SaccyDRAFT_2462	0.0005446	45.0	COG3462@1|root,COG3462@2|Bacteria,2GWIQ@201174|Actinobacteria	201174|Actinobacteria	S	membrane protein (DUF2078)	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8046445_1	644966.Tmar_1540	4.976e-18	89.0	COG3547@1|root,COG3547@2|Bacteria,1TQ5G@1239|Firmicutes,247ME@186801|Clostridia	186801|Clostridia	L	COG3547, transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
HKD2_k127_8046445_0	485913.Krac_9173	4.258e-83	287.0	COG0515@1|root,COG0515@2|Bacteria	485913.Krac_9173|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8053786_2	211165.AJLN01000116_gene3027	5.019e-06	51.0	2BQR2@1|root,32JMN@2|Bacteria,1G66W@1117|Cyanobacteria,1JM7F@1189|Stigonemataceae	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8053786_0	485913.Krac_11299	8.403e-152	494.0	COG2607@1|root,COG2607@2|Bacteria	2|Bacteria	E	Atpase (Aaa	MA20_41470	-	-	ko:K06923	-	-	-	-	ko00000	-	-	-	DUF815
HKD2_k127_8053786_1	485913.Krac_11726	3.648e-33	130.0	COG0318@1|root,COG3321@1|root,COG0318@2|Bacteria,COG3321@2|Bacteria,2G68I@200795|Chloroflexi	200795|Chloroflexi	IQ	PFAM short-chain dehydrogenase reductase SDR	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,Acyl_transf_1,KAsynt_C_assoc,Ketoacyl-synt_C,PP-binding,ketoacyl-synt
HKD2_k127_8054729_2	485913.Krac_3943	2.566e-31	125.0	COG3316@1|root,COG3316@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K18320	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS240
HKD2_k127_8054729_0	395961.Cyan7425_2664	5.401e-165	527.0	COG1453@1|root,COG1453@2|Bacteria	2|Bacteria	S	Aldo/keto reductase family	asrA	-	-	ko:K16950	ko00920,ko01120,map00920,map01120	-	R00858,R10146	RC00065	ko00000,ko00001	-	-	-	Aldo_ket_red,Fer4_22
HKD2_k127_8054729_1	481448.Minf_2388	7.397e-47	173.0	COG0664@1|root,COG0664@2|Bacteria,46W2B@74201|Verrucomicrobia,37GWV@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	T	Cyclic nucleotide-monophosphate binding domain	crp	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
HKD2_k127_8054729_3	159450.NH14_30340	2.1e-10	63.0	COG0543@1|root,COG0543@2|Bacteria,1R6QZ@1224|Proteobacteria,2VSRF@28216|Betaproteobacteria	28216|Betaproteobacteria	CH	Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B	-	-	-	-	-	-	-	-	-	-	-	-	DHODB_Fe-S_bind,NAD_binding_1
HKD2_k127_8060854_2	485913.Krac_8566	6.631e-12	68.0	COG0582@1|root,COG0582@2|Bacteria,2G7XX@200795|Chloroflexi	200795|Chloroflexi	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_3,Phage_integrase
HKD2_k127_8060854_4	632518.Calow_0804	1.356e-06	51.0	COG0582@1|root,COG0582@2|Bacteria,1TTJI@1239|Firmicutes,247V6@186801|Clostridia,42G18@68295|Thermoanaerobacterales	186801|Clostridia	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Arm-DNA-bind_4,Phage_int_SAM_3,Phage_integrase
HKD2_k127_8060854_0	485913.Krac_10924	8.956e-204	638.0	COG0473@1|root,COG0473@2|Bacteria,2G68P@200795|Chloroflexi	200795|Chloroflexi	C	Isocitrate/isopropylmalate dehydrogenase	-	-	1.1.1.41	ko:K00030	ko00020,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010	R00709	RC00114	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
HKD2_k127_8060854_1	485913.Krac_10923	5.995e-185	581.0	COG1494@1|root,COG1494@2|Bacteria,2G5XR@200795|Chloroflexi	200795|Chloroflexi	G	TIGRFAM fructose-1,6-bisphosphatase, class II	glpX	-	3.1.3.11	ko:K02446	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200	M00003,M00165,M00167	R00762,R04780	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FBPase_glpX
HKD2_k127_8060854_3	485913.Krac_10922	3.473e-11	63.0	COG0194@1|root,COG0194@2|Bacteria,2G6EW@200795|Chloroflexi	200795|Chloroflexi	F	Essential for recycling GMP and indirectly, cGMP	gmk	-	2.7.4.8	ko:K00942	ko00230,ko01100,map00230,map01100	M00050	R00332,R02090	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_kin
HKD2_k127_8066069_0	1121889.AUDM01000002_gene369	8.736e-72	253.0	COG3408@1|root,COG3408@2|Bacteria,4NGZM@976|Bacteroidetes,1I02Y@117743|Flavobacteriia,2NTCE@237|Flavobacterium	976|Bacteroidetes	G	Alkaline and neutral invertase	-	-	-	-	-	-	-	-	-	-	-	-	GDE_C,Glyco_hydro_100,S6PP
HKD2_k127_8070262_2	251229.Chro_3667	5.705e-13	70.0	COG3208@1|root,COG3208@2|Bacteria,1G16V@1117|Cyanobacteria,3VJJB@52604|Pleurocapsales	1117|Cyanobacteria	Q	thioesterase involved in non-ribosomal peptide biosynthesis	-	-	3.1.2.21	ko:K01071	ko00061,ko01100,map00061,map01100	-	R04014,R08157,R08158	RC00014,RC00039	ko00000,ko00001,ko01000,ko01004	-	-	-	Thioesterase
HKD2_k127_8070262_1	1499967.BAYZ01000156_gene566	6.512e-51	189.0	COG2091@1|root,COG2091@2|Bacteria,2NQZE@2323|unclassified Bacteria	2|Bacteria	H	4'-phosphopantetheinyl transferase superfamily	hetI	-	2.7.8.7	ko:K00997,ko:K06133	ko00770,map00770	-	R01625	RC00002	ko00000,ko00001,ko01000	-	-	-	ACPS
HKD2_k127_8070262_0	485913.Krac_11724	9.02e-255	796.0	COG1020@1|root,COG1020@2|Bacteria,2G86H@200795|Chloroflexi	200795|Chloroflexi	Q	PFAM AMP-dependent synthetase and ligase	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding
HKD2_k127_8074471_5	1382306.JNIM01000001_gene3910	5.073e-21	101.0	COG4818@1|root,COG4818@2|Bacteria,2G9D6@200795|Chloroflexi	200795|Chloroflexi	S	TM2 domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4870
HKD2_k127_8074471_0	485913.Krac_0007	0.0	1237.0	COG0466@1|root,COG0466@2|Bacteria,2G7KC@200795|Chloroflexi	200795|Chloroflexi	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	-	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
HKD2_k127_8074471_1	1382306.JNIM01000001_gene3912	3.489e-243	755.0	COG1219@1|root,COG1219@2|Bacteria,2G661@200795|Chloroflexi	200795|Chloroflexi	O	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP	clpX	-	-	ko:K03544	ko04112,map04112	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA_2,ClpB_D2-small,zf-C4_ClpX
HKD2_k127_8074471_2	485913.Krac_0005	3.696e-151	488.0	COG0544@1|root,COG0544@2|Bacteria,2G6GA@200795|Chloroflexi	200795|Chloroflexi	D	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase	tig	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03545	-	-	-	-	ko00000	-	-	-	FKBP_C,Trigger_C,Trigger_N
HKD2_k127_8074471_4	1382306.JNIM01000001_gene3913	1.165e-24	104.0	COG0544@1|root,COG0544@2|Bacteria,2G6GA@200795|Chloroflexi	200795|Chloroflexi	D	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase	tig	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03545	-	-	-	-	ko00000	-	-	-	FKBP_C,Trigger_C,Trigger_N
HKD2_k127_8074471_3	485913.Krac_0003	1.214e-90	303.0	COG0855@1|root,COG0855@2|Bacteria,2G68J@200795|Chloroflexi	200795|Chloroflexi	H	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)	ppk	-	2.7.4.1	ko:K00937	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PP_kinase,PP_kinase_C,PP_kinase_N
HKD2_k127_8094134_0	1382306.JNIM01000001_gene3625	1.593e-130	445.0	COG0745@1|root,COG0745@2|Bacteria	1382306.JNIM01000001_gene3625|-	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8094134_1	485913.Krac_9094	3.099e-62	216.0	COG0745@1|root,COG0745@2|Bacteria	485913.Krac_9094|-	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8099613_0	485913.Krac_4138	1.758e-57	201.0	COG1504@1|root,COG1504@2|Bacteria	2|Bacteria	L	Protein of unknown function (DUF498/DUF598)	-	-	-	-	-	-	-	-	-	-	-	-	DUF498
HKD2_k127_8099613_1	1121378.KB899772_gene609	1.43e-40	160.0	COG0654@1|root,COG0654@2|Bacteria	2|Bacteria	CH	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases	-	-	1.14.13.182	ko:K17940	ko00405,ko01130,ko02024,ko02025,map00405,map01130,map02024,map02025	-	R10467	RC00236	ko00000,ko00001,ko01000	-	-	-	FAD_binding_3,FMN_red
HKD2_k127_8101439_0	1382306.JNIM01000001_gene438	5.41e-194	646.0	COG5305@1|root,COG5305@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HKD2_k127_8101439_1	485913.Krac_3365	1.428e-46	173.0	COG3293@1|root,COG3293@2|Bacteria	2|Bacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_2,DUF4096
HKD2_k127_8101439_2	317619.ANKN01000024_gene1584	3.263e-43	162.0	COG3293@1|root,COG3293@2|Bacteria,1G0BW@1117|Cyanobacteria	1117|Cyanobacteria	L	Transposase	-	-	-	ko:K07492	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DUF4096
HKD2_k127_810283_1	485913.Krac_2417	1.836e-34	137.0	COG2244@1|root,COG2244@2|Bacteria,2G9NI@200795|Chloroflexi	200795|Chloroflexi	S	polysaccharide biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_810283_0	485913.Krac_2416	7.949e-56	206.0	COG2244@1|root,COG2244@2|Bacteria	2|Bacteria	S	polysaccharide biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt
HKD2_k127_8106496_6	485913.Krac_8646	6.116e-14	76.0	COG0773@1|root,COG0773@2|Bacteria,2G5J4@200795|Chloroflexi	200795|Chloroflexi	M	Belongs to the MurCDEF family	murC	-	6.3.2.8	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R03193	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
HKD2_k127_8106496_2	485913.Krac_8647	5.226e-156	500.0	COG0707@1|root,COG0707@2|Bacteria,2G6EH@200795|Chloroflexi	200795|Chloroflexi	M	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)	murG	-	2.4.1.227	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	-	R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011	-	GT28	-	Glyco_tran_28_C,Glyco_transf_28
HKD2_k127_8106496_1	1382306.JNIM01000001_gene36	6.529e-193	616.0	COG0772@1|root,COG0772@2|Bacteria,2G5MQ@200795|Chloroflexi	200795|Chloroflexi	D	Belongs to the SEDS family	ftsW	-	-	ko:K03588	ko04112,map04112	-	-	-	ko00000,ko00001,ko02000,ko03036	2.A.103.1	-	-	FTSW_RODA_SPOVE
HKD2_k127_8106496_0	485913.Krac_8650	5.224e-239	751.0	COG0768@1|root,COG0768@2|Bacteria,2G66C@200795|Chloroflexi	200795|Chloroflexi	M	Penicillin-binding protein, dimerisation domain	ftsI	-	3.4.16.4	ko:K03587	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011,ko03036	-	-	-	PBP_dimer,Transpeptidase
HKD2_k127_8106496_5	1382306.JNIM01000001_gene33	8.222e-32	130.0	2DR6K@1|root,33AE2@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	FtsL
HKD2_k127_8106496_3	485913.Krac_8652	7.967e-139	448.0	COG0275@1|root,COG0275@2|Bacteria,2G658@200795|Chloroflexi	200795|Chloroflexi	J	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA	rsmH	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.199	ko:K03438	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltransf_5
HKD2_k127_8106496_4	485913.Krac_8653	4.674e-61	213.0	COG2001@1|root,COG2001@2|Bacteria,2G6ZC@200795|Chloroflexi	200795|Chloroflexi	K	Belongs to the MraZ family	mraZ	-	-	ko:K03925	-	-	-	-	ko00000	-	-	-	MraZ
HKD2_k127_8113543_0	349521.HCH_02725	1.402e-28	127.0	COG3919@1|root,COG3919@2|Bacteria,1R94Z@1224|Proteobacteria,1RQ74@1236|Gammaproteobacteria,1XM2N@135619|Oceanospirillales	135619|Oceanospirillales	S	ATP-grasp	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_3
HKD2_k127_8113543_1	866776.HMPREF9321_0778	2.924e-28	126.0	COG0726@1|root,COG0726@2|Bacteria,1VDVD@1239|Firmicutes,4H58K@909932|Negativicutes	909932|Negativicutes	G	Polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
HKD2_k127_8113543_2	864051.BurJ1DRAFT_2702	2.064e-05	51.0	COG3266@1|root,COG3266@2|Bacteria,1R0CZ@1224|Proteobacteria	1224|Proteobacteria	I	PFAM Prenyltransferase squalene oxidase	-	-	-	-	-	-	-	-	-	-	-	-	VCBS
HKD2_k127_8117918_0	1382306.JNIM01000001_gene234	1.012e-232	736.0	COG0465@1|root,COG0465@2|Bacteria,2G5JA@200795|Chloroflexi	200795|Chloroflexi	O	Belongs to the AAA ATPase family	-	-	-	-	-	-	-	-	-	-	-	-	AAA,Peptidase_M41
HKD2_k127_8122657_0	485913.Krac_7852	8.507e-30	124.0	arCOG03842@1|root,30WW9@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF929)	-	-	-	-	-	-	-	-	-	-	-	-	DUF929
HKD2_k127_8122657_1	317936.Nos7107_5314	2.523e-21	108.0	COG3464@1|root,COG3464@2|Bacteria,1G9CU@1117|Cyanobacteria	1117|Cyanobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8143331_0	485913.Krac_11308	6.388e-56	202.0	2APF0@1|root,31EHN@2|Bacteria,2G7DI@200795|Chloroflexi	200795|Chloroflexi	S	Putative zincin peptidase	-	-	-	-	-	-	-	-	-	-	-	-	DUF3267
HKD2_k127_8143331_1	485913.Krac_11307	1.773e-53	190.0	COG0266@1|root,COG0266@2|Bacteria,2G6BB@200795|Chloroflexi	200795|Chloroflexi	L	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates	fpg	-	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
HKD2_k127_8145584_1	485913.Krac_11821	6.631e-164	522.0	COG2262@1|root,COG2262@2|Bacteria,2G634@200795|Chloroflexi	200795|Chloroflexi	S	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis	hflX	-	-	ko:K03665	-	-	-	-	ko00000,ko03009	-	-	-	GTP-bdg_M,GTP-bdg_N,MMR_HSR1
HKD2_k127_8145584_6	1123226.KB899279_gene2373	4.048e-28	124.0	COG1277@1|root,COG1277@2|Bacteria,1V2H6@1239|Firmicutes,4HC35@91061|Bacilli,26UJ7@186822|Paenibacillaceae	91061|Bacilli	S	ABC-2 family transporter protein	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane_2,ABC2_membrane_3
HKD2_k127_8145584_5	485913.Krac_5098	3.873e-41	156.0	COG1695@1|root,COG1695@2|Bacteria	2|Bacteria	K	negative regulation of transcription, DNA-templated	-	-	-	-	-	-	-	-	-	-	-	-	PadR
HKD2_k127_8145584_9	234267.Acid_4526	0.0005513	51.0	COG0577@1|root,COG0577@2|Bacteria,3Y36E@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HKD2_k127_8145584_8	646529.Desaci_2534	5.643e-05	54.0	2EUC9@1|root,33MUN@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8145584_7	1382306.JNIM01000001_gene565	5.429e-21	93.0	2DRHT@1|root,33BTG@2|Bacteria,2G7I1@200795|Chloroflexi	200795|Chloroflexi	S	TIGRFAM lysine biosynthesis protein LysW	-	-	-	ko:K05826	-	M00031,M00763	-	-	ko00000,ko00001,ko00002	-	-	-	-
HKD2_k127_8145584_2	1382306.JNIM01000001_gene566	1.048e-143	459.0	COG0189@1|root,COG0189@2|Bacteria,2G5RN@200795|Chloroflexi	200795|Chloroflexi	HJ	Belongs to the RimK family	-	-	6.3.2.43	ko:K05827	ko00300,ko01100,ko01210,ko01230,map00300,map01100,map01210,map01230	M00031	R09775	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	RimK
HKD2_k127_8145584_0	1382306.JNIM01000001_gene567	1.211e-170	541.0	COG0002@1|root,COG0002@2|Bacteria,2G5W0@200795|Chloroflexi	200795|Chloroflexi	E	Catalyzes the NADPH-dependent reduction of LysW - aminoadipate 6-phosphate to yield LysW -aminoadipate 6- semialdehyde	lysY	-	-	ko:K05829	ko00220,ko00300,ko01100,ko01110,ko01210,ko01230,map00220,map00300,map01100,map01110,map01210,map01230	M00031,M00763	R09777,R10931	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
HKD2_k127_8145584_4	1382306.JNIM01000001_gene568	3.37e-110	362.0	COG0548@1|root,COG0548@2|Bacteria,2G5WV@200795|Chloroflexi	200795|Chloroflexi	E	Belongs to the acetylglutamate kinase family. LysZ subfamily	lysZ	-	-	ko:K05828	ko00220,ko00300,ko01100,ko01110,ko01210,ko01230,map00220,map00300,map01100,map01110,map01210,map01230	M00031,M00763	R09776,R10930	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase
HKD2_k127_8145584_3	485913.Krac_11812	3.965e-140	449.0	COG0624@1|root,COG4992@1|root,COG0624@2|Bacteria,COG4992@2|Bacteria,2G5SG@200795|Chloroflexi	200795|Chloroflexi	E	Catalyzes the transfer of the amino group of L-glutamate to LysW -aminoadipate 6-semialdehyde, generating LysW -gamma-L- lysine	lysJ	-	-	ko:K05830	ko00220,ko00300,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01130,map01210,map01230	M00031,M00763	R09778,R10932	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3,Peptidase_M20
HKD2_k127_8176138_1	485913.Krac_12204	6.495e-25	104.0	COG2141@1|root,COG2141@2|Bacteria,2G727@200795|Chloroflexi	200795|Chloroflexi	C	Luciferase-like monooxygenase	-	-	1.5.98.2	ko:K00320	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R04464	RC01607	ko00000,ko00001,ko00002,ko01000	-	-	-	Bac_luciferase
HKD2_k127_8176138_0	485913.Krac_12203	6.547e-138	451.0	COG0501@1|root,COG0501@2|Bacteria,2G6KE@200795|Chloroflexi	200795|Chloroflexi	O	PFAM peptidase M48 Ste24p	-	-	3.4.24.84	ko:K06013	ko00900,ko01130,map00900,map01130	-	R09845	RC00141	ko00000,ko00001,ko01000,ko01002,ko04147	-	-	-	Peptidase_M48,Peptidase_M48_N
HKD2_k127_8179031_1	880072.Desac_1648	1.03e-28	130.0	COG3919@1|root,COG3919@2|Bacteria,1R94Z@1224|Proteobacteria,42U1R@68525|delta/epsilon subdivisions,2X2JR@28221|Deltaproteobacteria,2MS8F@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	ATP-grasp domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8179031_0	1382306.JNIM01000001_gene1502	8.09e-88	304.0	COG2072@1|root,COG2072@2|Bacteria	2|Bacteria	P	N,N-dimethylaniline monooxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	K_oxygenase,Pyr_redox_2,Pyr_redox_3
HKD2_k127_8179031_2	1274524.BSONL12_18339	4.655e-07	57.0	COG0726@1|root,COG0726@2|Bacteria,1V6AW@1239|Firmicutes,4HHC9@91061|Bacilli,1ZQ8K@1386|Bacillus	91061|Bacilli	G	Polysaccharide deacetylase	yxkH	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1,SLAP
HKD2_k127_8197422_2	479434.Sthe_3211	6.497e-45	168.0	COG3039@1|root,COG3039@2|Bacteria,2G8FF@200795|Chloroflexi	200795|Chloroflexi	L	PFAM transposase, IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
HKD2_k127_8197422_1	479434.Sthe_2571	3.913e-45	168.0	COG3039@1|root,COG3039@2|Bacteria,2G8FF@200795|Chloroflexi	200795|Chloroflexi	L	PFAM transposase, IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
HKD2_k127_8197422_0	485913.Krac_7239	2.751e-52	197.0	COG0589@1|root,COG0589@2|Bacteria,2G768@200795|Chloroflexi	200795|Chloroflexi	T	Belongs to the universal stress protein A family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD2_k127_8197422_3	383372.Rcas_4052	5.244e-16	81.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1145@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1145@2|Bacteria,2G5M1@200795|Chloroflexi,376VN@32061|Chloroflexia	32061|Chloroflexia	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	-	-	1.2.7.1	ko:K03737	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00173,M00307	R01196,R10866	RC00004,RC02742	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	EKR,Fer4_16,PFOR_II,POR,POR_N,TPP_enzyme_C
HKD2_k127_8204150_1	485913.Krac_4113	3.036e-06	50.0	COG3335@1|root,COG3335@2|Bacteria,2G8EF@200795|Chloroflexi	200795|Chloroflexi	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8219046_1	351607.Acel_1068	9.178e-244	758.0	COG0365@1|root,COG0365@2|Bacteria,2GJCG@201174|Actinobacteria,4ERWG@85013|Frankiales	201174|Actinobacteria	I	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	-	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
HKD2_k127_8219046_3	485913.Krac_12012	2.464e-61	222.0	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	vipF	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1
HKD2_k127_8219046_0	485913.Krac_12013	7.224e-312	961.0	COG1884@1|root,COG1884@2|Bacteria,2G62T@200795|Chloroflexi	200795|Chloroflexi	I	TIGRFAM methylmalonyl-CoA mutase, large subunit	-	-	5.4.99.2	ko:K01848	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	MM_CoA_mutase
HKD2_k127_8219046_2	485913.Krac_12015	9.011e-70	238.0	COG0183@1|root,COG0183@2|Bacteria,2G66E@200795|Chloroflexi	200795|Chloroflexi	I	Belongs to the thiolase family	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
HKD2_k127_8220077_0	485913.Krac_7865	7.962e-196	640.0	COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,2G5ZX@200795|Chloroflexi	200795|Chloroflexi	F	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth	guaB	-	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,IMPDH
HKD2_k127_8255225_0	1521187.JPIM01000050_gene3440	1.034e-51	206.0	COG1672@1|root,COG1672@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,CHAT,NB-ARC,Pkinase,TPR_12,TPR_7,TPR_8
HKD2_k127_8258669_0	485913.Krac_2680	2.206e-135	445.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria	485913.Krac_2680|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8258669_1	485913.Krac_2679	6.123e-115	382.0	COG5001@1|root,COG5001@2|Bacteria	2|Bacteria	T	cyclic-guanylate-specific phosphodiesterase activity	-	-	-	-	-	-	-	-	-	-	-	-	CHASE,EAL,GGDEF,HATPase_c,PAS_3,PAS_4,PAS_9,TPR_12,dCache_1
HKD2_k127_8272264_0	1382306.JNIM01000001_gene3842	1.654e-139	454.0	COG0624@1|root,COG0624@2|Bacteria	2|Bacteria	E	succinyl-diaminopimelate desuccinylase activity	cpg2	-	3.4.17.11	ko:K01295	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
HKD2_k127_8272264_1	485913.Krac_12154	9.762e-48	175.0	COG1132@1|root,COG1132@2|Bacteria,2G5P7@200795|Chloroflexi	200795|Chloroflexi	V	PFAM ABC transporter related	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
HKD2_k127_8273459_1	1382306.JNIM01000001_gene436	6.446e-05	47.0	COG0845@1|root,COG0845@2|Bacteria	2|Bacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
HKD2_k127_828260_1	485913.Krac_2675	1.13e-36	144.0	COG2050@1|root,COG2050@2|Bacteria	2|Bacteria	Q	thiolester hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	4HBT,DUF4442,YiiD_C
HKD2_k127_828260_0	485913.Krac_11269	7.133e-131	424.0	COG3191@1|root,COG3191@2|Bacteria,2G6BG@200795|Chloroflexi	200795|Chloroflexi	EQ	PFAM peptidase S58, DmpA	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S58
HKD2_k127_8284494_0	485913.Krac_7489	4.088e-227	724.0	COG3852@1|root,COG3852@2|Bacteria,2G96T@200795|Chloroflexi	200795|Chloroflexi	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS
HKD2_k127_8288902_0	485913.Krac_10934	2.395e-192	619.0	COG0457@1|root,COG0457@2|Bacteria	485913.Krac_10934|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8308094_2	1382306.JNIM01000001_gene1518	3.028e-33	140.0	COG0515@1|root,COG1672@1|root,COG0515@2|Bacteria,COG1672@2|Bacteria,2G8HW@200795|Chloroflexi	200795|Chloroflexi	KLT	Peptidase C14 caspase catalytic subunit p20	-	-	-	-	-	-	-	-	-	-	-	-	WD40
HKD2_k127_8308094_3	713586.KB900536_gene457	3.456e-16	87.0	COG1572@1|root,COG1572@2|Bacteria	2|Bacteria	NU	bacterial-type flagellum-dependent cell motility	-	-	3.4.21.10	ko:K01317	-	-	-	-	ko00000,ko01000,ko01002,ko04131	-	-	-	BatA,CARDB,F5_F8_type_C,HemolysinCabind,Laminin_G_3,NIDO,VWA_2
HKD2_k127_8308094_0	485913.Krac_9252	3.677e-143	457.0	COG3316@1|root,COG3316@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS240
HKD2_k127_8308094_1	485913.Krac_2474	2.024e-37	141.0	COG3328@1|root,COG3328@2|Bacteria,2G6SX@200795|Chloroflexi	200795|Chloroflexi	L	PFAM transposase mutator type	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_mut
HKD2_k127_8308954_0	485913.Krac_8690	1.587e-211	664.0	COG1387@1|root,COG1387@2|Bacteria,2G5K6@200795|Chloroflexi	200795|Chloroflexi	L	PHP domain protein	-	-	-	ko:K02347	-	-	-	-	ko00000,ko03400	-	-	-	DNA_pol_B_thumb,HHH_5,HHH_8,PHP
HKD2_k127_8308954_1	1382306.JNIM01000001_gene3871	8.875e-54	196.0	COG1825@1|root,COG1825@2|Bacteria,2G6YX@200795|Chloroflexi	200795|Chloroflexi	J	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance	ctc	-	-	ko:K02897	ko03010,map03010	M00178	-	-	ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L25p,Ribosomal_TL5_C
HKD2_k127_8308954_2	485913.Krac_8688	3.795e-27	111.0	COG0438@1|root,COG0438@2|Bacteria,2G8P6@200795|Chloroflexi	200795|Chloroflexi	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
HKD2_k127_8313166_0	1128421.JAGA01000003_gene2865	8.867e-230	728.0	COG1080@1|root,COG1080@2|Bacteria,2NNQF@2323|unclassified Bacteria	2|Bacteria	G	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)	fruB	-	2.7.1.202,2.7.3.9	ko:K02768,ko:K08483,ko:K11183,ko:K11189	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	M00273	R03232	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.2.1,8.A.7	-	-	PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C,PTS-HPr,PTS_EIIA_2
HKD2_k127_8313166_1	1382306.JNIM01000001_gene1559	2.18e-142	459.0	COG1609@1|root,COG1609@2|Bacteria,2G6CQ@200795|Chloroflexi	200795|Chloroflexi	K	Periplasmic binding protein LacI transcriptional regulator	-	-	-	ko:K03435	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
HKD2_k127_8324510_0	1195236.CTER_1812	7.043e-97	326.0	COG1131@1|root,COG1131@2|Bacteria,1TQUS@1239|Firmicutes,25AZ1@186801|Clostridia,3WH5S@541000|Ruminococcaceae	186801|Clostridia	V	ABC-type multidrug transport system ATPase component	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
HKD2_k127_8337880_3	485913.Krac_7652	7.389e-06	48.0	2ASZS@1|root,31IFG@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2
HKD2_k127_8337880_2	485913.Krac_7651	3.295e-23	104.0	COG0116@1|root,COG0116@2|Bacteria,2G8DP@200795|Chloroflexi	200795|Chloroflexi	L	RNA methylase	-	-	-	-	-	-	-	-	-	-	-	-	UPF0020
HKD2_k127_8337880_0	485913.Krac_7651	7.691e-75	256.0	COG0116@1|root,COG0116@2|Bacteria,2G8DP@200795|Chloroflexi	200795|Chloroflexi	L	RNA methylase	-	-	-	-	-	-	-	-	-	-	-	-	UPF0020
HKD2_k127_8337880_1	485913.Krac_7650	1.008e-36	139.0	COG0231@1|root,COG0231@2|Bacteria,2G6P4@200795|Chloroflexi	200795|Chloroflexi	J	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase	efp	GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K02356	-	-	-	-	ko00000,ko03012	-	-	-	EFP,EFP_N,Elong-fact-P_C
HKD2_k127_8338320_1	1382306.JNIM01000001_gene3350	7.782e-118	385.0	COG0508@1|root,COG0508@2|Bacteria	2|Bacteria	C	S-acyltransferase activity	bkdF	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
HKD2_k127_8338320_0	485913.Krac_8388	1.523e-185	590.0	COG1249@1|root,COG1249@2|Bacteria,2G5MR@200795|Chloroflexi	200795|Chloroflexi	C	Pyridine nucleotide-disulphide oxidoreductase dimerisation region	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,Pyr_redox_dim
HKD2_k127_8353596_0	1382306.JNIM01000001_gene3021	1.957e-257	801.0	COG1457@1|root,COG1457@2|Bacteria	2|Bacteria	F	cytosine transport	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8354119_0	485913.Krac_11972	0.0	1022.0	COG1331@1|root,COG1331@2|Bacteria,2G5R1@200795|Chloroflexi	200795|Chloroflexi	O	Protein of unknown function, DUF255	-	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	GlcNAc_2-epim,Thioredox_DsbH
HKD2_k127_8354119_1	1382306.JNIM01000001_gene467	4.463e-63	224.0	COG0589@1|root,COG0589@2|Bacteria	2|Bacteria	T	AMP binding	-	-	-	-	-	-	-	-	-	-	-	-	SpoIIAA-like,Usp
HKD2_k127_8357752_0	485913.Krac_11844	1.23e-203	648.0	COG0477@1|root,COG0477@2|Bacteria,2G5J9@200795|Chloroflexi	200795|Chloroflexi	P	TIGRFAM drug resistance transporter, EmrB QacA subfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD2_k127_8357752_1	485913.Krac_4743	2.207e-43	159.0	COG0675@1|root,COG0675@2|Bacteria,2G8WI@200795|Chloroflexi	2|Bacteria	L	TIGRFAM transposase, IS605 OrfB family, central region	-	-	-	ko:K07496	-	-	-	-	ko00000	-	-	-	OrfB_IS605,OrfB_Zn_ribbon
HKD2_k127_8360958_0	485913.Krac_1330	1.008e-195	619.0	COG0373@1|root,COG0373@2|Bacteria,2G5T4@200795|Chloroflexi	200795|Chloroflexi	H	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)	hemA	-	1.2.1.70	ko:K02492	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R04109	RC00055,RC00149	ko00000,ko00001,ko00002,ko01000	-	-	-	GlutR_N,GlutR_dimer,Shikimate_DH
HKD2_k127_8360958_1	1382306.JNIM01000001_gene2443	1.594e-30	121.0	COG0190@1|root,COG0190@2|Bacteria,2G6BA@200795|Chloroflexi	200795|Chloroflexi	F	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate	folD	GO:0003674,GO:0003824,GO:0004477,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0019238,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114	1.5.1.5,3.5.4.9	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R01220,R01655	RC00202,RC00578	ko00000,ko00001,ko00002,ko01000	-	-	-	THF_DHG_CYH,THF_DHG_CYH_C
HKD2_k127_8379032_0	485913.Krac_8440	4.412e-117	383.0	COG2239@1|root,COG2239@2|Bacteria,2G6H7@200795|Chloroflexi	200795|Chloroflexi	P	Acts as a magnesium transporter	-	-	-	ko:K06213	-	-	-	-	ko00000,ko02000	1.A.26.1	-	-	CBS,MgtE,MgtE_N
HKD2_k127_8379032_4	485913.Krac_1738	2.024e-21	103.0	COG1357@1|root,COG1357@2|Bacteria,2G7HW@200795|Chloroflexi	200795|Chloroflexi	S	PFAM pentapeptide repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	Pentapeptide
HKD2_k127_8379032_1	485913.Krac_8444	1.691e-70	242.0	COG0782@1|root,COG0782@2|Bacteria,2G6U9@200795|Chloroflexi	200795|Chloroflexi	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides	greA	-	-	ko:K03624	-	-	-	-	ko00000,ko03021	-	-	-	GreA_GreB,GreA_GreB_N
HKD2_k127_8379032_2	1382306.JNIM01000001_gene3410	1.144e-68	249.0	COG0596@1|root,COG0596@2|Bacteria	2|Bacteria	S	hydrolase activity, acting on ester bonds	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
HKD2_k127_8380338_0	1382306.JNIM01000001_gene2707	1.933e-82	292.0	COG0515@1|root,COG0515@2|Bacteria	1382306.JNIM01000001_gene2707|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8380338_2	1382306.JNIM01000001_gene489	1.646e-17	96.0	COG1716@1|root,COG1716@2|Bacteria	2|Bacteria	T	histone H2A K63-linked ubiquitination	-	-	-	-	-	-	-	-	-	-	-	-	FHA,GAF_2,Tail_P2_I
HKD2_k127_8380338_1	485913.Krac_1590	3.124e-67	232.0	COG1252@1|root,COG1252@2|Bacteria,2G5SS@200795|Chloroflexi	200795|Chloroflexi	C	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	1.6.99.3	ko:K03885	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
HKD2_k127_8381964_2	747365.Thena_0130	4.929e-13	73.0	COG0859@1|root,COG0859@2|Bacteria,1TRN2@1239|Firmicutes,24W0F@186801|Clostridia	186801|Clostridia	M	COGs COG0859 ADP-heptose LPS heptosyltransferase	-	-	-	ko:K02841,ko:K02843	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9
HKD2_k127_8381964_0	1382306.JNIM01000001_gene293	4.101e-60	213.0	COG1225@1|root,COG1225@2|Bacteria,2G8QZ@200795|Chloroflexi	200795|Chloroflexi	O	PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	-	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
HKD2_k127_8381964_1	1382306.JNIM01000001_gene2482	1.872e-49	189.0	COG3662@1|root,COG3662@2|Bacteria,2G8VS@200795|Chloroflexi	200795|Chloroflexi	S	Uncharacterized protein conserved in bacteria (DUF2236)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2236
HKD2_k127_8384716_0	485913.Krac_8328	3.391e-129	426.0	COG0628@1|root,COG0628@2|Bacteria,2G6TV@200795|Chloroflexi	200795|Chloroflexi	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
HKD2_k127_8384716_1	1304876.AZVC01000014_gene2487	3.269e-45	165.0	COG0574@1|root,COG3848@1|root,COG0574@2|Bacteria,COG3848@2|Bacteria,2GMN4@201174|Actinobacteria,1W8NY@1268|Micrococcaceae	201174|Actinobacteria	GT	Pyruvate phosphate dikinase, PEP/pyruvate binding domain	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PPDK_N
HKD2_k127_8384881_0	485913.Krac_2704	1.619e-94	315.0	COG0568@1|root,COG0568@2|Bacteria,2G5W3@200795|Chloroflexi	200795|Chloroflexi	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r3,Sigma70_r4
HKD2_k127_8386990_2	485913.Krac_2770	1.382e-30	126.0	28Z60@1|root,2ZKYA@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8386990_0	485913.Krac_7504	8.864e-137	444.0	COG2195@1|root,COG2195@2|Bacteria,2G7H0@200795|Chloroflexi	200795|Chloroflexi	E	Peptidase dimerisation domain	-	-	3.4.11.4	ko:K01258	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
HKD2_k127_8402844_1	485913.Krac_0958	7.424e-162	525.0	COG0515@1|root,COG0515@2|Bacteria,2G850@200795|Chloroflexi	200795|Chloroflexi	KLT	Serine threonine protein kinase	-	-	2.7.11.1	ko:K08884	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HKD2_k127_8402844_0	485913.Krac_0957	2.25e-172	549.0	COG0123@1|root,COG0123@2|Bacteria,2G5X3@200795|Chloroflexi	200795|Chloroflexi	BQ	PFAM histone deacetylase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
HKD2_k127_8402844_2	395961.Cyan7425_4066	5.437e-06	53.0	COG0346@1|root,COG0346@2|Bacteria,1GAPT@1117|Cyanobacteria	1117|Cyanobacteria	E	Glyoxalase-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HKD2_k127_8404597_1	1382306.JNIM01000001_gene876	1.027e-61	215.0	COG0384@1|root,COG0384@2|Bacteria,2G7RE@200795|Chloroflexi	200795|Chloroflexi	S	Phenazine biosynthesis-like protein	-	-	-	-	-	-	-	-	-	-	-	-	PhzC-PhzF
HKD2_k127_8404597_0	1120950.KB892757_gene6616	3.525e-66	233.0	COG0637@1|root,COG0637@2|Bacteria,2IQD3@201174|Actinobacteria,4DRPS@85009|Propionibacteriales	201174|Actinobacteria	S	Haloacid dehalogenase-like hydrolase	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2
HKD2_k127_8404597_2	485913.Krac_11300	1.019e-58	207.0	COG0745@1|root,COG0745@2|Bacteria	485913.Krac_11300|-	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8404597_3	485913.Krac_6563	1.89e-06	50.0	COG3677@1|root,COG3677@2|Bacteria,2G6SJ@200795|Chloroflexi	200795|Chloroflexi	L	PFAM Transposase IS66 family	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8405747_2	485913.Krac_7860	2.501e-24	102.0	COG1100@1|root,COG1100@2|Bacteria,2G6A7@200795|Chloroflexi	200795|Chloroflexi	S	ADP-ribosylation factor family	-	-	-	ko:K06883	-	-	-	-	ko00000	-	-	-	Arf
HKD2_k127_8405747_0	1382306.JNIM01000001_gene866	3.085e-127	413.0	COG0697@1|root,COG0697@2|Bacteria,2G70T@200795|Chloroflexi	200795|Chloroflexi	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HKD2_k127_8405747_1	485913.Krac_7858	2.309e-60	213.0	COG4087@1|root,COG4087@2|Bacteria,2G99M@200795|Chloroflexi	200795|Chloroflexi	S	Haloacid dehalogenase domain protein hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_3
HKD2_k127_8405747_3	867845.KI911784_gene1008	4.537e-17	81.0	COG3293@1|root,COG3293@2|Bacteria	2|Bacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_2,DUF4096
HKD2_k127_8410839_0	634497.HAH_0363	7.328e-52	195.0	COG0438@1|root,arCOG01403@2157|Archaea,2XUJN@28890|Euryarchaeota,23TVP@183963|Halobacteria	183963|Halobacteria	M	COG0438 Glycosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
HKD2_k127_8410839_1	287986.DV20_23830	3.05e-15	77.0	COG0438@1|root,COG0438@2|Bacteria,2GSQI@201174|Actinobacteria,4E1TK@85010|Pseudonocardiales	201174|Actinobacteria	M	Glycosyl transferase 4-like	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4
HKD2_k127_8418282_0	485913.Krac_8693	2.313e-141	455.0	COG0596@1|root,COG0596@2|Bacteria,2G7BF@200795|Chloroflexi	200795|Chloroflexi	S	PFAM alpha beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
HKD2_k127_8426739_4	485913.Krac_2937	6.944e-10	63.0	COG1819@1|root,COG1819@2|Bacteria,2G7HK@200795|Chloroflexi	200795|Chloroflexi	CG	TIGRFAM glycosyltransferase, MGT family	-	-	-	-	-	-	-	-	-	-	-	-	UDPGT
HKD2_k127_8426739_3	485913.Krac_5106	3.509e-16	81.0	COG1819@1|root,COG1819@2|Bacteria,2G7HK@200795|Chloroflexi	200795|Chloroflexi	CG	TIGRFAM glycosyltransferase, MGT family	-	-	-	-	-	-	-	-	-	-	-	-	UDPGT
HKD2_k127_8426739_1	1382306.JNIM01000001_gene2312	6.244e-162	515.0	COG1457@1|root,COG1457@2|Bacteria	2|Bacteria	F	cytosine transport	-	-	-	ko:K03457	-	-	-	-	ko00000	2.A.39	-	-	Transp_cyt_pur
HKD2_k127_8426739_2	485913.Krac_3039	4.456e-38	146.0	COG1457@1|root,COG1457@2|Bacteria	2|Bacteria	F	cytosine transport	-	-	-	ko:K03457	-	-	-	-	ko00000	2.A.39	-	-	Transp_cyt_pur
HKD2_k127_8426739_0	485913.Krac_7493	4.845e-255	803.0	COG2203@1|root,COG2508@1|root,COG3605@1|root,COG2203@2|Bacteria,COG2508@2|Bacteria,COG3605@2|Bacteria,2G67M@200795|Chloroflexi	2|Bacteria	T	PFAM GAF domain protein	-	-	4.1.2.17	ko:K01628,ko:K03406,ko:K21009	ko00051,ko01120,ko02020,ko02025,ko02030,map00051,map01120,map02020,map02025,map02030	-	R02262	RC00603,RC00604	ko00000,ko00001,ko01000,ko02035	-	-	-	GAF,GAF_2,HATPase_c,HTH_30,HisKA,MCPsignal,PAS,PAS_3,PAS_4,PAS_9,Response_reg
HKD2_k127_8472409_1	485913.Krac_7781	3.212e-107	352.0	COG0052@1|root,COG0052@2|Bacteria,2G5J2@200795|Chloroflexi	200795|Chloroflexi	J	Belongs to the universal ribosomal protein uS2 family	rpsB	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
HKD2_k127_8472409_2	485913.Krac_7780	4.166e-99	327.0	COG0264@1|root,COG0264@2|Bacteria,2G6MJ@200795|Chloroflexi	200795|Chloroflexi	J	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome	tsf	-	-	ko:K02357	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EF_TS
HKD2_k127_8472409_0	485913.Krac_7779	2.606e-124	400.0	COG0528@1|root,COG0528@2|Bacteria,2G5RG@200795|Chloroflexi	200795|Chloroflexi	F	Catalyzes the reversible phosphorylation of UMP to UDP	pyrH	GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901576	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
HKD2_k127_8487326_0	485913.Krac_7790	2.297e-259	805.0	COG0064@1|root,COG0064@2|Bacteria,2G62Q@200795|Chloroflexi	200795|Chloroflexi	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatB	-	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	GatB_N,GatB_Yqey
HKD2_k127_8487326_1	1382306.JNIM01000001_gene1328	2.486e-225	703.0	COG0334@1|root,COG0334@2|Bacteria,2G5SR@200795|Chloroflexi	200795|Chloroflexi	C	Belongs to the Glu Leu Phe Val dehydrogenases family	-	-	1.4.1.3	ko:K00261	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
HKD2_k127_8501288_0	1382306.JNIM01000001_gene2607	9.046e-196	618.0	COG1104@1|root,COG1104@2|Bacteria,2G63V@200795|Chloroflexi	200795|Chloroflexi	E	Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins	iscS	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
HKD2_k127_8501288_1	485913.Krac_6831	9.995e-195	613.0	COG0436@1|root,COG0436@2|Bacteria,2G5MC@200795|Chloroflexi	200795|Chloroflexi	E	aminotransferase class I and II	aspC	-	-	ko:K10907	-	-	-	-	ko00000,ko01000,ko01007	-	-	-	Aminotran_1_2
HKD2_k127_8501288_2	485913.Krac_6830	2.149e-55	196.0	COG2761@1|root,COG2761@2|Bacteria,2G9IQ@200795|Chloroflexi	200795|Chloroflexi	Q	DSBA-like thioredoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	DSBA
HKD2_k127_8506038_0	485913.Krac_6922	1.289e-35	146.0	COG0494@1|root,COG0758@1|root,COG0494@2|Bacteria,COG0758@2|Bacteria	2|Bacteria	LU	DNA mediated transformation	nudE	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0019144,GO:0043167,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0046872	-	ko:K04096,ko:K08312	ko00230,map00230	-	R01054	RC00002	ko00000,ko00001,ko01000	-	-	iAPECO1_1312.APECO1_3067,iE2348C_1286.E2348C_3641,iECABU_c1320.ECABU_c38150,iECED1_1282.ECED1_4056,iECNA114_1301.ECNA114_3494,iECOK1_1307.ECOK1_3810,iECP_1309.ECP_3483,iECS88_1305.ECS88_3783,iECSF_1327.ECSF_3218,iLF82_1304.LF82_1531,iNRG857_1313.NRG857_16815,iUMN146_1321.UM146_17040,iUTI89_1310.UTI89_C3895,ic_1306.c4167	DNA_processg_A,NUDIX
HKD2_k127_8514098_0	485913.Krac_12022	5.484e-209	657.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,2G5W2@200795|Chloroflexi	200795|Chloroflexi	G	Belongs to the PEP-utilizing enzyme family	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
HKD2_k127_8517999_0	485913.Krac_12366	3.807e-138	441.0	COG1192@1|root,COG1192@2|Bacteria,2G62U@200795|Chloroflexi	200795|Chloroflexi	D	PFAM Cobyrinic acid a,c-diamide synthase	-	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
HKD2_k127_8517999_1	471875.RUMLAC_00984	4.155e-61	223.0	COG1475@1|root,COG1475@2|Bacteria,1TQ2B@1239|Firmicutes,249VV@186801|Clostridia,3WHV1@541000|Ruminococcaceae	186801|Clostridia	K	Belongs to the ParB family	spo0J	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
HKD2_k127_8517999_2	1382306.JNIM01000001_gene3826	7.658e-47	173.0	COG1011@1|root,COG1011@2|Bacteria	2|Bacteria	S	phosphatase activity	-	-	3.8.1.2	ko:K01560,ko:K07025	ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120	-	R05287	RC00697	ko00000,ko00001,ko01000	-	-	-	DinB_2,HAD_2
HKD2_k127_8526306_0	485913.Krac_11283	1.796e-114	377.0	COG0005@1|root,COG0005@2|Bacteria,2G5KQ@200795|Chloroflexi	200795|Chloroflexi	F	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate	punA	-	2.4.2.1	ko:K03783	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R01561,R01863,R01969,R02147,R02294,R02295,R02297,R02484,R02557,R02748,R08368,R10244	RC00033,RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	PNP_UDP_1
HKD2_k127_8526306_1	324602.Caur_2486	1.901e-68	242.0	COG4974@1|root,COG4974@2|Bacteria,2G6CI@200795|Chloroflexi,3754J@32061|Chloroflexia	32061|Chloroflexia	L	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids	xerC	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
HKD2_k127_8526654_0	485913.Krac_10623	0.0	1170.0	COG0022@1|root,COG1071@1|root,COG0022@2|Bacteria,COG1071@2|Bacteria	2|Bacteria	C	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor	-	-	1.2.4.4	ko:K00166,ko:K00167,ko:K11381	ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130	M00036	R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00027,RC00627,RC02743,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh,Transket_pyr,Transketolase_C
HKD2_k127_8526654_4	485913.Krac_10622	7.608e-63	223.0	2DU3X@1|root,33NUX@2|Bacteria	2|Bacteria	S	Double zinc ribbon	-	-	-	-	-	-	-	-	-	-	-	-	zinc_ribbon_2
HKD2_k127_8526654_1	485913.Krac_10621	2.719e-197	623.0	COG0612@1|root,COG0612@2|Bacteria,2G672@200795|Chloroflexi	200795|Chloroflexi	S	PFAM peptidase M16 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
HKD2_k127_8526654_2	485913.Krac_10620	3.204e-158	529.0	COG0457@1|root,COG0457@2|Bacteria,2G70Z@200795|Chloroflexi	200795|Chloroflexi	O	Tetratricopeptide TPR_2 repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r1_1,TPR_16,TPR_19,TPR_8
HKD2_k127_8526654_5	485913.Krac_10619	2.516e-47	173.0	COG2018@1|root,COG2018@2|Bacteria,2G9R6@200795|Chloroflexi	200795|Chloroflexi	S	PFAM Roadblock LC7 family protein	-	-	-	ko:K07131	-	-	-	-	ko00000	-	-	-	Robl_LC7
HKD2_k127_8526654_3	485913.Krac_10618	2.611e-71	243.0	COG0105@1|root,COG0105@2|Bacteria,2G6NP@200795|Chloroflexi	200795|Chloroflexi	F	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate	ndk	GO:0003674,GO:0003824,GO:0004550,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006165,GO:0006220,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009132,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0019205,GO:0019637,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046483,GO:0046939,GO:0055086,GO:0071704,GO:0072521,GO:0072527,GO:1901360,GO:1901564	2.7.4.6	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	M00049,M00050,M00052,M00053	R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895	RC00002	ko00000,ko00001,ko00002,ko01000,ko04131	-	-	-	NDK
HKD2_k127_8529847_2	485913.Krac_8730	8.695e-48	176.0	COG2009@1|root,COG2009@2|Bacteria,2G7CW@200795|Chloroflexi	200795|Chloroflexi	C	succinate dehydrogenase, cytochrome	-	-	-	ko:K00241	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	Sdh_cyt
HKD2_k127_8529847_1	485913.Krac_8731	4.345e-60	211.0	COG2142@1|root,COG2142@2|Bacteria,2G7EN@200795|Chloroflexi	200795|Chloroflexi	C	Succinate dehydrogenase/Fumarate reductase transmembrane subunit	-	-	-	ko:K00242	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	Sdh_cyt
HKD2_k127_8529847_0	485913.Krac_8732	1.416e-109	355.0	COG1053@1|root,COG1053@2|Bacteria,2G5YB@200795|Chloroflexi	200795|Chloroflexi	C	PFAM fumarate reductase succinate dehydrogenase flavoprotein domain protein	-	-	1.3.5.1,1.3.5.4	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
HKD2_k127_8542030_3	485913.Krac_11683	3.898e-40	154.0	COG3688@1|root,COG3688@2|Bacteria	2|Bacteria	D	RNA-binding protein containing a PIN domain	yacP	-	-	ko:K06962	-	-	-	-	ko00000	-	-	-	EFG_C,EFG_IV,GTP_EFTU,NYN_YacP
HKD2_k127_8542030_1	485913.Krac_11684	1.017e-116	398.0	COG1216@1|root,COG1216@2|Bacteria,2G69V@200795|Chloroflexi	200795|Chloroflexi	S	PFAM Glycosyl transferase family 2	-	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2
HKD2_k127_8542030_0	485913.Krac_11685	5.467e-117	398.0	COG0392@1|root,COG0392@2|Bacteria,2G6EN@200795|Chloroflexi	200795|Chloroflexi	S	PFAM conserved	-	-	-	-	-	-	-	-	-	-	-	-	LPG_synthase_TM
HKD2_k127_8542030_2	485913.Krac_11686	6.388e-74	253.0	COG0382@1|root,COG0382@2|Bacteria,2G5WY@200795|Chloroflexi	200795|Chloroflexi	H	PFAM UbiA prenyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	UbiA
HKD2_k127_8559806_0	485913.Krac_7757	7.919e-174	550.0	COG1012@1|root,COG1012@2|Bacteria,2G61H@200795|Chloroflexi	200795|Chloroflexi	C	Belongs to the aldehyde dehydrogenase family	-	-	1.2.1.88	ko:K00294	ko00250,ko00330,ko01100,map00250,map00330,map01100	-	R00245,R00707,R00708,R04444,R04445,R05051	RC00080,RC00216,RC00242,RC00255	ko00000,ko00001,ko01000	-	-	-	Aldedh
HKD2_k127_8559806_1	1382306.JNIM01000001_gene1353	3.96e-140	451.0	COG0491@1|root,COG0491@2|Bacteria,2G6KC@200795|Chloroflexi	200795|Chloroflexi	S	PFAM beta-lactamase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HKD2_k127_8559806_2	1382306.JNIM01000001_gene414	1.761e-19	96.0	COG3428@1|root,COG3428@2|Bacteria,2G72V@200795|Chloroflexi	200795|Chloroflexi	K	Bacterial PH domain	-	-	-	-	-	-	-	-	-	-	-	-	bPH_2
HKD2_k127_8559806_3	313612.L8106_00635	2.63e-05	52.0	COG1724@1|root,COG1724@2|Bacteria,1G8YW@1117|Cyanobacteria,1HD4D@1150|Oscillatoriales	1117|Cyanobacteria	N	HicA toxin of bacterial toxin-antitoxin,	-	-	-	-	-	-	-	-	-	-	-	-	HicA_toxin
HKD2_k127_8576441_1	1382306.JNIM01000001_gene3919	2.105e-37	142.0	COG2197@1|root,COG2197@2|Bacteria,2G6JC@200795|Chloroflexi	200795|Chloroflexi	K	Two component transcriptional regulator, LuxR family	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HKD2_k127_8576441_4	1382306.JNIM01000001_gene1697	4.738e-16	88.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25,Methyltransf_31
HKD2_k127_8576441_0	1382306.JNIM01000001_gene3915	9.59e-48	184.0	COG0500@1|root,COG2226@2|Bacteria,2G9IX@200795|Chloroflexi	2|Bacteria	Q	Putative methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25,Methyltransf_31,Ubie_methyltran
HKD2_k127_8576441_2	1382306.JNIM01000001_gene1697	2.916e-30	132.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25,Methyltransf_31
HKD2_k127_8576441_3	1382306.JNIM01000001_gene3915	3.605e-24	113.0	COG0500@1|root,COG2226@2|Bacteria,2G9IX@200795|Chloroflexi	2|Bacteria	Q	Putative methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25,Methyltransf_31,Ubie_methyltran
HKD2_k127_8606788_0	485913.Krac_8789	2.821e-214	671.0	COG1232@1|root,COG1232@2|Bacteria,2G5VN@200795|Chloroflexi	200795|Chloroflexi	H	PFAM amine oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
HKD2_k127_8610131_2	485913.Krac_9337	1.207e-14	74.0	COG0247@1|root,COG1139@1|root,COG0247@2|Bacteria,COG1139@2|Bacteria,2G665@200795|Chloroflexi	200795|Chloroflexi	C	Iron-sulfur cluster binding protein	-	-	-	ko:K18929	-	-	-	-	ko00000	-	-	-	CCG,DUF3390,Fer4_7,Fer4_8,LUD_dom
HKD2_k127_8610131_1	485913.Krac_9337	1.429e-40	151.0	COG0247@1|root,COG1139@1|root,COG0247@2|Bacteria,COG1139@2|Bacteria,2G665@200795|Chloroflexi	200795|Chloroflexi	C	Iron-sulfur cluster binding protein	-	-	-	ko:K18929	-	-	-	-	ko00000	-	-	-	CCG,DUF3390,Fer4_7,Fer4_8,LUD_dom
HKD2_k127_8610131_0	485913.Krac_0473	1.065e-196	618.0	COG0514@1|root,COG0514@2|Bacteria,2G6S8@200795|Chloroflexi	200795|Chloroflexi	L	ATP-dependent DNA helicase RecQ	-	-	3.6.4.12	ko:K03654	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,HRDC,HTH_40,Helicase_C,RQC,RecQ_Zn_bind
HKD2_k127_8629675_0	485913.Krac_10628	7.832e-112	366.0	COG2159@1|root,COG2159@2|Bacteria,2G6EZ@200795|Chloroflexi	200795|Chloroflexi	S	Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
HKD2_k127_8629675_1	485913.Krac_10626	1.607e-61	216.0	COG1051@1|root,COG1051@2|Bacteria,2G8SP@200795|Chloroflexi	200795|Chloroflexi	F	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
HKD2_k127_8631689_0	485913.Krac_7571	4.081e-216	678.0	COG2409@1|root,COG2409@2|Bacteria,2G6XZ@200795|Chloroflexi	200795|Chloroflexi	S	PFAM MMPL domain protein	-	-	-	ko:K06994	-	-	-	-	ko00000	-	-	-	MMPL
HKD2_k127_8631689_1	1382306.JNIM01000001_gene981	9.31e-05	46.0	COG5621@1|root,COG5621@2|Bacteria,2G6EI@200795|Chloroflexi	200795|Chloroflexi	S	Lipocalin-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CrtC,Lipocalin_9
HKD2_k127_8634855_1	485913.Krac_4354	1.988e-45	167.0	COG3189@1|root,COG3189@2|Bacteria,2G90C@200795|Chloroflexi	200795|Chloroflexi	S	Protein of unknown function, DUF488	-	-	-	-	-	-	-	-	-	-	-	-	DUF488
HKD2_k127_8634855_0	485913.Krac_3475	7.127e-155	497.0	COG2223@1|root,COG2223@2|Bacteria,2G9HC@200795|Chloroflexi	200795|Chloroflexi	P	nitrite transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8650423_1	485913.Krac_12003	6.312e-98	346.0	COG0631@1|root,COG0631@2|Bacteria,2G8RD@200795|Chloroflexi	200795|Chloroflexi	T	SMART protein phosphatase 2C domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PP2C
HKD2_k127_8650423_2	1382306.JNIM01000001_gene447	5.513e-29	118.0	COG0515@1|root,COG0515@2|Bacteria,2G5NM@200795|Chloroflexi	200795|Chloroflexi	KLT	Serine threonine protein kinase	-	-	2.7.11.1	ko:K08884	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_16
HKD2_k127_8650423_0	485913.Krac_12005	1.652e-229	716.0	COG0141@1|root,COG0141@2|Bacteria,2G5KP@200795|Chloroflexi	200795|Chloroflexi	E	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine	hisD	-	1.1.1.23	ko:K00013	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01158,R01163,R03012	RC00099,RC00242,RC00463	ko00000,ko00001,ko00002,ko01000	-	-	-	Histidinol_dh
HKD2_k127_865105_1	485913.Krac_9293	3.014e-22	98.0	COG1937@1|root,COG1937@2|Bacteria	2|Bacteria	S	negative regulation of transcription, DNA-templated	csoR_2	-	-	ko:K21600	-	-	-	-	ko00000,ko03000	-	-	-	Trns_repr_metal
HKD2_k127_865105_0	485913.Krac_3256	1.751e-153	503.0	COG0654@1|root,COG0654@2|Bacteria,2G7MQ@200795|Chloroflexi	200795|Chloroflexi	C	COGs COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3
HKD2_k127_8653733_0	1382306.JNIM01000001_gene1029	1.654e-29	119.0	COG1832@1|root,COG1832@2|Bacteria,2G6VU@200795|Chloroflexi	200795|Chloroflexi	S	PFAM CoA-binding domain protein	-	-	-	ko:K06929	-	-	-	-	ko00000	-	-	-	CoA_binding_2
HKD2_k127_8701372_0	485913.Krac_9921	7.97e-160	510.0	COG0644@1|root,COG0644@2|Bacteria,2G7FR@200795|Chloroflexi	200795|Chloroflexi	C	TIGRFAM geranylgeranyl reductase	-	-	1.3.1.111,1.3.1.83	ko:K10960	ko00860,ko00900,ko01100,ko01110,map00860,map00900,map01100,map01110	-	R02063,R08754,R08755,R08756,R11226,R11518	RC00212,RC00522,RC01823	ko00000,ko00001,ko01000	-	-	-	FAD_binding_3,FAD_oxidored,HI0933_like
HKD2_k127_8701372_1	485913.Krac_9922	7.869e-96	319.0	29UQ5@1|root,30G1W@2|Bacteria	2|Bacteria	C	spheroidene monooxygenase	crtA	-	1.14.15.9	ko:K09847	ko00906,ko01100,map00906,map01100	-	R07525,R07526,R07537,R07538	RC02084	ko00000,ko00001,ko01000	-	-	-	DUF3291
HKD2_k127_8707011_2	1382306.JNIM01000001_gene3304	2.739e-09	59.0	2DPJ9@1|root,332BI@2|Bacteria,2GBP4@200795|Chloroflexi	2|Bacteria	S	Domain of unknown function (DUF4397)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4397
HKD2_k127_8707011_0	485913.Krac_7522	6.899e-171	539.0	COG1830@1|root,COG1830@2|Bacteria,2G8VI@200795|Chloroflexi	200795|Chloroflexi	G	DeoC/LacD family aldolase	-	-	4.1.2.13	ko:K11645	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	DeoC
HKD2_k127_8707011_1	485913.Krac_7508	1.318e-49	177.0	COG0492@1|root,COG0492@2|Bacteria,2G5Z5@200795|Chloroflexi	200795|Chloroflexi	C	FAD-dependent pyridine nucleotide-disulphide oxidoreductase	trxB	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
HKD2_k127_8714900_0	1382306.JNIM01000001_gene2645	2.872e-150	481.0	COG0180@1|root,COG0180@2|Bacteria,2G5SH@200795|Chloroflexi	200795|Chloroflexi	J	PFAM aminoacyl-tRNA synthetase class Ib	trpS	-	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
HKD2_k127_8714900_1	485913.Krac_10776	7.964e-40	152.0	COG0741@1|root,COG0741@2|Bacteria,2G7EW@200795|Chloroflexi	200795|Chloroflexi	M	Transglycosylase SLT domain	-	-	-	-	-	-	-	-	-	-	-	-	LysM,SLT
HKD2_k127_8722104_0	485913.Krac_8186	4.531e-78	264.0	COG0589@1|root,COG0589@2|Bacteria,2G7D7@200795|Chloroflexi	200795|Chloroflexi	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD2_k127_8722104_1	485913.Krac_8187	8.503e-78	265.0	COG2203@1|root,COG2203@2|Bacteria	2|Bacteria	T	Gaf domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2
HKD2_k127_872794_1	485913.Krac_8881	2.666e-08	55.0	2DMUC@1|root,32TQR@2|Bacteria,2G6MF@200795|Chloroflexi	200795|Chloroflexi	S	CpXC protein	-	-	-	-	-	-	-	-	-	-	-	-	CpXC
HKD2_k127_872794_0	1382306.JNIM01000001_gene3568	3.585e-196	617.0	COG1630@1|root,COG1630@2|Bacteria	2|Bacteria	S	NurA	-	-	-	-	-	-	-	-	-	-	-	-	NurA
HKD2_k127_873673_2	485913.Krac_11587	5.74e-29	117.0	COG0004@1|root,COG0004@2|Bacteria,2G5N8@200795|Chloroflexi	200795|Chloroflexi	P	PFAM Rh family protein ammonium transporter	amt	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
HKD2_k127_873673_0	1382306.JNIM01000001_gene1041	6.598e-45	168.0	COG1846@1|root,COG1846@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
HKD2_k127_873673_1	485913.Krac_6679	1.447e-36	145.0	COG1807@1|root,COG1807@2|Bacteria,2G991@200795|Chloroflexi	200795|Chloroflexi	M	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_875704_1	485913.Krac_10544	3.789e-315	973.0	COG0021@1|root,COG0021@2|Bacteria,2G63Z@200795|Chloroflexi	200795|Chloroflexi	G	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate	-	-	-	-	-	-	-	-	-	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
HKD2_k127_875704_3	485913.Krac_10542	1.533e-107	355.0	COG0328@1|root,COG0328@2|Bacteria,2G6PS@200795|Chloroflexi	200795|Chloroflexi	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhA	-	3.1.26.4	ko:K03469	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	Cauli_VI,RNase_H
HKD2_k127_875704_4	485913.Krac_10541	1.637e-107	352.0	COG2043@1|root,COG2043@2|Bacteria	2|Bacteria	C	Uncharacterised ArCR, COG2043	-	-	-	-	-	-	-	-	-	-	-	-	DUF169
HKD2_k127_875704_2	1198452.Jab_1c14220	6.263e-129	419.0	COG0274@1|root,COG0274@2|Bacteria,1N8AG@1224|Proteobacteria,2VP4F@28216|Betaproteobacteria,47291@75682|Oxalobacteraceae	28216|Betaproteobacteria	F	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate	deoC	-	4.1.2.4	ko:K01619	ko00030,map00030	-	R01066	RC00436,RC00437	ko00000,ko00001,ko01000	-	-	-	DeoC
HKD2_k127_875704_0	1382306.JNIM01000001_gene2493	0.0	1264.0	COG1012@1|root,COG1012@2|Bacteria,2G86D@200795|Chloroflexi	200795|Chloroflexi	C	Aldehyde dehydrogenase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldedh
HKD2_k127_8761914_1	1521187.JPIM01000222_gene946	3.598e-23	102.0	COG0490@1|root,COG1226@1|root,COG4651@1|root,COG0490@2|Bacteria,COG1226@2|Bacteria,COG4651@2|Bacteria,2G5QY@200795|Chloroflexi,376DS@32061|Chloroflexia	32061|Chloroflexia	P	Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family	-	-	-	ko:K03455	-	-	-	-	ko00000	2.A.37	-	-	Na_H_Exchanger,TrkA_C,TrkA_N
HKD2_k127_8761914_0	485913.Krac_3320	5.665e-69	237.0	COG1733@1|root,COG1733@2|Bacteria	2|Bacteria	K	regulation of RNA biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	HxlR
HKD2_k127_8775098_2	485913.Krac_8363	1.052e-51	184.0	COG1662@1|root,COG3677@1|root,COG1662@2|Bacteria,COG3677@2|Bacteria,2G9MB@200795|Chloroflexi	200795|Chloroflexi	L	Putative ATPase subunit of terminase (gpP-like)	-	-	-	-	-	-	-	-	-	-	-	-	HTH_23
HKD2_k127_8775098_0	485913.Krac_8447	2.491e-90	302.0	COG0344@1|root,COG0344@2|Bacteria,2G6U5@200795|Chloroflexi	200795|Chloroflexi	I	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP	plsY	-	2.3.1.15	ko:K08591	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	G3P_acyltransf
HKD2_k127_8775098_1	485913.Krac_8448	2.72e-82	278.0	COG0558@1|root,COG0558@2|Bacteria,2G7HQ@200795|Chloroflexi	200795|Chloroflexi	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	-	-	2.7.8.5	ko:K00995	ko00564,ko01100,map00564,map01100	-	R01801	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
HKD2_k127_8775098_3	1382306.JNIM01000001_gene3497	2.081e-09	59.0	COG1041@1|root,COG1041@2|Bacteria	2|Bacteria	L	tRNA (guanine-N2-)-methyltransferase activity	-	-	2.1.1.156,2.1.1.187,2.1.1.72	ko:K00563,ko:K00571,ko:K07319,ko:K18896	ko00260,map00260	-	R07233,R10060	RC00003,RC03038	ko00000,ko00001,ko01000,ko02048,ko03009	-	-	-	Methyltransf_25,N6_N4_Mtase,UPF0020
HKD2_k127_8806168_1	1128421.JAGA01000002_gene1753	1.597e-54	208.0	COG0642@1|root,COG5002@1|root,COG2205@2|Bacteria,COG5002@2|Bacteria,2NPIU@2323|unclassified Bacteria	2|Bacteria	T	His Kinase A (phosphoacceptor) domain	-	-	2.7.13.3	ko:K07636	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	GAF,GAF_2,HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_9,Response_reg
HKD2_k127_8815935_0	1133850.SHJG_8002	6.62e-109	364.0	2DBCN@1|root,2Z8EJ@2|Bacteria,2I6NC@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8815935_1	1123360.thalar_02869	1.425e-47	172.0	29FX8@1|root,302UX@2|Bacteria,1RKA5@1224|Proteobacteria,2UH09@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8819167_0	109760.SPPG_05395T0	0.000159	53.0	2CN71@1|root,2QUA6@2759|Eukaryota,3ACP5@33154|Opisthokonta,3P4WX@4751|Fungi	4751|Fungi	S	NYN domain	-	-	-	-	-	-	-	-	-	-	-	-	NYN
HKD2_k127_8819762_0	485913.Krac_11738	5.012e-119	386.0	COG1051@1|root,COG1051@2|Bacteria,2G6QH@200795|Chloroflexi	200795|Chloroflexi	F	Belongs to the Nudix hydrolase family	-	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX
HKD2_k127_8819762_1	485913.Krac_11737	8.494e-71	244.0	COG1335@1|root,COG1335@2|Bacteria,2G6JY@200795|Chloroflexi	200795|Chloroflexi	Q	Isochorismatase family	-	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
HKD2_k127_882599_0	1382306.JNIM01000001_gene3938	2.486e-87	297.0	2DBT9@1|root,32TY2@2|Bacteria,2G95T@200795|Chloroflexi	200795|Chloroflexi	-	-	-	-	-	ko:K07234	-	-	-	-	ko00000	-	-	-	-
HKD2_k127_8829403_0	485913.Krac_8548	4.114e-171	549.0	COG0210@1|root,COG0210@2|Bacteria,2G7JM@200795|Chloroflexi	200795|Chloroflexi	L	PFAM UvrD REP helicase	-	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	PDDEXK_1,Peptidase_M78,UvrD-helicase,UvrD_C
HKD2_k127_8829403_2	485913.Krac_8550	9.85e-25	104.0	COG1521@1|root,COG1521@2|Bacteria,2G6B4@200795|Chloroflexi	200795|Chloroflexi	F	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis	coaX	-	2.7.1.33	ko:K03525	ko00770,ko01100,map00770,map01100	M00120	R02971,R03018,R04391	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Pan_kinase
HKD2_k127_8832583_0	1382306.JNIM01000001_gene435	2.075e-44	175.0	COG0392@1|root,COG0392@2|Bacteria,2G9G7@200795|Chloroflexi	200795|Chloroflexi	S	Lysylphosphatidylglycerol synthase TM region	-	-	-	ko:K07027	-	-	-	-	ko00000,ko02000	4.D.2	-	-	LPG_synthase_TM
HKD2_k127_8832583_1	1499967.BAYZ01000195_gene3102	5.583e-42	158.0	COG0438@1|root,COG0438@2|Bacteria,2NQRB@2323|unclassified Bacteria	2|Bacteria	M	Glycosyl transferase 4-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
HKD2_k127_8855814_0	485913.Krac_8197	3.357e-228	712.0	COG0172@1|root,COG0172@2|Bacteria,2G5PD@200795|Chloroflexi	200795|Chloroflexi	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Seryl_tRNA_N,tRNA-synt_2b
HKD2_k127_8861054_0	1382306.JNIM01000001_gene981	7.155e-144	464.0	COG5621@1|root,COG5621@2|Bacteria,2G6EI@200795|Chloroflexi	200795|Chloroflexi	S	Lipocalin-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CrtC,Lipocalin_9
HKD2_k127_8861054_1	485913.Krac_7568	2.705e-123	410.0	COG0642@1|root,COG2205@2|Bacteria	485913.Krac_7568|-	T	PhoQ Sensor	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8862628_1	485913.Krac_8748	4.636e-33	131.0	COG0736@1|root,COG0736@2|Bacteria,2G73N@200795|Chloroflexi	200795|Chloroflexi	I	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein	acpS	-	2.7.8.7	ko:K00997	ko00770,map00770	-	R01625	RC00002	ko00000,ko00001,ko01000	-	-	-	ACPS
HKD2_k127_8862628_0	485913.Krac_8749	9.032e-233	727.0	COG1004@1|root,COG1004@2|Bacteria,2G62F@200795|Chloroflexi	200795|Chloroflexi	C	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	-	-	1.1.1.22	ko:K00012	ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100	M00014,M00129,M00361,M00362	R00286	RC00291	ko00000,ko00001,ko00002,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
HKD2_k127_8862628_2	485913.Krac_8750	5.991e-21	92.0	COG0491@1|root,COG0491@2|Bacteria,2G6X9@200795|Chloroflexi	200795|Chloroflexi	S	beta-lactamase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HKD2_k127_8867129_0	266117.Rxyl_0429	1.504e-36	141.0	COG4319@1|root,COG4319@2|Bacteria,2II14@201174|Actinobacteria,4CTN6@84995|Rubrobacteria	84995|Rubrobacteria	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_2
HKD2_k127_8867129_1	1382306.JNIM01000001_gene846	5.323e-16	79.0	COG3224@1|root,COG3224@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K09932	-	-	-	-	ko00000	-	-	-	ABM
HKD2_k127_8867129_2	1382306.JNIM01000001_gene2642	3.096e-09	59.0	COG0672@1|root,COG0672@2|Bacteria	2|Bacteria	P	high-affinity ferrous iron transmembrane transporter activity	efeU	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K07243	-	-	-	-	ko00000,ko02000	2.A.108.1,2.A.108.2	-	-	FTR1,Peptidase_M75
HKD2_k127_8869905_0	926569.ANT_19690	1.421e-36	152.0	COG0624@1|root,COG0624@2|Bacteria,2G5IT@200795|Chloroflexi	200795|Chloroflexi	E	PFAM peptidase M20	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
HKD2_k127_887231_0	1382306.JNIM01000001_gene2933	4.501e-233	749.0	COG0451@1|root,COG0451@2|Bacteria,2G74B@200795|Chloroflexi	200795|Chloroflexi	GM	Protein of unknown function (DUF4012)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4012
HKD2_k127_887231_1	485913.Krac_11945	2.221e-214	674.0	COG0389@1|root,COG0389@2|Bacteria	2|Bacteria	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	dinB	-	2.7.7.7	ko:K02346	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C,IMS_HHH
HKD2_k127_8922205_1	485913.Krac_11235	1.831e-116	379.0	COG2025@1|root,COG2025@2|Bacteria,2G6PP@200795|Chloroflexi	200795|Chloroflexi	C	electron transfer flavoprotein, alpha subunit	-	-	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	-	ETF,ETF_alpha
HKD2_k127_8922205_0	1382306.JNIM01000001_gene2732	2.963e-126	409.0	COG2086@1|root,COG2086@2|Bacteria,2G6YY@200795|Chloroflexi	200795|Chloroflexi	C	PFAM Electron transfer flavoprotein alpha beta-subunit	-	-	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
HKD2_k127_8922205_2	926569.ANT_10500	1.343e-69	247.0	COG0524@1|root,COG0524@2|Bacteria,2G73H@200795|Chloroflexi	200795|Chloroflexi	G	PFAM PfkB domain protein	-	-	2.7.1.15,2.7.1.4	ko:K00847,ko:K00852	ko00030,ko00051,ko00500,ko00520,ko01100,map00030,map00051,map00500,map00520,map01100	-	R00760,R00867,R01051,R02750,R03920	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
HKD2_k127_8922205_3	485913.Krac_2104	1.074e-19	91.0	COG2120@1|root,COG2120@2|Bacteria	2|Bacteria	S	N-acetylglucosaminylinositol deacetylase activity	-	-	3.5.1.115	ko:K18455	-	-	-	-	ko00000,ko01000	-	-	-	PIG-L
HKD2_k127_8922728_0	485913.Krac_11307	1.466e-134	434.0	COG0266@1|root,COG0266@2|Bacteria,2G6BB@200795|Chloroflexi	200795|Chloroflexi	L	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates	fpg	-	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
HKD2_k127_8958905_1	357808.RoseRS_0798	8.057e-38	147.0	COG0265@1|root,COG0265@2|Bacteria,2G8UH@200795|Chloroflexi	200795|Chloroflexi	O	PFAM peptidase S1 and S6, chymotrypsin Hap	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
HKD2_k127_8958905_0	383372.Rcas_1230	6.106e-93	311.0	COG0265@1|root,COG0265@2|Bacteria,2G6I9@200795|Chloroflexi,376AN@32061|Chloroflexia	32061|Chloroflexia	O	PFAM peptidase S1 and S6, chymotrypsin Hap	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
HKD2_k127_8968439_0	485913.Krac_9189	0.0	1163.0	COG0210@1|root,COG0210@2|Bacteria,2G5XF@200795|Chloroflexi	200795|Chloroflexi	L	PFAM UvrD REP helicase	pcrA	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
HKD2_k127_8968439_1	485913.Krac_12265	9.146e-220	689.0	COG0174@1|root,COG0174@2|Bacteria,2G5U2@200795|Chloroflexi	200795|Chloroflexi	E	PFAM glutamine synthetase catalytic region	glnA	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
HKD2_k127_8977233_0	1382306.JNIM01000001_gene2397	2.625e-98	331.0	COG5002@1|root,COG5002@2|Bacteria	2|Bacteria	T	protein histidine kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HAMP,HATPase_c,HisKA,PAS_4,dCache_1
HKD2_k127_8981548_1	1382306.JNIM01000001_gene1364	5.834e-89	298.0	COG0272@1|root,COG0272@2|Bacteria,2G5TK@200795|Chloroflexi	200795|Chloroflexi	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5
HKD2_k127_8981548_2	485913.Krac_7677	4.539e-46	168.0	COG2329@1|root,COG2329@2|Bacteria	2|Bacteria	S	heme oxygenase (decyclizing) activity	-	-	-	-	-	-	-	-	-	-	-	-	ABM
HKD2_k127_8981548_0	1382306.JNIM01000001_gene1365	5.864e-122	400.0	COG1502@1|root,COG1502@2|Bacteria,2G9TQ@200795|Chloroflexi	200795|Chloroflexi	I	Archaeal transcriptional regulator TrmB	-	-	-	-	-	-	-	-	-	-	-	-	PLDc_2
HKD2_k127_8987461_0	485913.Krac_9237	6.979e-105	349.0	COG0573@1|root,COG0573@2|Bacteria,2G62J@200795|Chloroflexi	200795|Chloroflexi	P	probably responsible for the translocation of the substrate across the membrane	-	-	-	ko:K02037	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
HKD2_k127_8987461_1	485913.Krac_9236	2.008e-83	287.0	COG0226@1|root,COG0226@2|Bacteria,2G7T2@200795|Chloroflexi	200795|Chloroflexi	P	TIGRFAM phosphate binding protein	pstS	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
HKD2_k127_8990719_0	485913.Krac_5417	1.102e-187	600.0	28MN1@1|root,2ZAXN@2|Bacteria,2G6CU@200795|Chloroflexi	200795|Chloroflexi	S	Terminase-like family	-	-	-	-	-	-	-	-	-	-	-	-	Terminase_6C
HKD2_k127_9021392_3	485913.Krac_2355	1.748e-130	419.0	COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,2G9RC@200795|Chloroflexi	200795|Chloroflexi	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_32
HKD2_k127_9021392_6	1229172.JQFA01000002_gene4233	1.076e-34	138.0	COG3415@1|root,COG3415@2|Bacteria,1G802@1117|Cyanobacteria	1117|Cyanobacteria	L	Homeodomain-like domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_23,HTH_32
HKD2_k127_9021392_8	1123248.KB893314_gene3685	0.0001193	46.0	COG0338@1|root,COG0338@2|Bacteria,4NFZ2@976|Bacteroidetes,1IUQP@117747|Sphingobacteriia	976|Bacteroidetes	L	D12 class N6 adenine-specific DNA methyltransferase	dam	-	2.1.1.72	ko:K06223	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko02048,ko03032,ko03400	-	-	-	MethyltransfD12
HKD2_k127_9021392_7	1429046.RR21198_3990	1.334e-33	136.0	COG4695@1|root,COG4695@2|Bacteria	2|Bacteria	N	Portal protein	gp34	-	-	-	-	-	-	-	-	-	-	-	Phage_portal
HKD2_k127_9021392_2	485913.Krac_11183	3.194e-180	574.0	COG2265@1|root,COG2265@2|Bacteria,2G6IV@200795|Chloroflexi	200795|Chloroflexi	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family	-	-	2.1.1.190	ko:K03215	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TRAM,tRNA_U5-meth_tr
HKD2_k127_9021392_4	485913.Krac_11182	2.342e-108	381.0	COG0457@1|root,COG0457@2|Bacteria	485913.Krac_11182|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9021392_0	485913.Krac_11181	3.324e-213	686.0	COG0457@1|root,COG0457@2|Bacteria	485913.Krac_11181|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9021392_1	485913.Krac_11180	1.036e-189	606.0	COG5650@1|root,COG5650@2|Bacteria	2|Bacteria	M	phosphatidylinositol metabolic process	-	-	-	ko:K13671	-	-	-	-	ko00000,ko01000,ko01003	-	GT87	-	GT87
HKD2_k127_9022446_0	485913.Krac_11293	2.512e-212	667.0	COG1180@1|root,COG1180@2|Bacteria	2|Bacteria	C	glycyl-radical enzyme activating activity	M1-291	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
HKD2_k127_9022446_1	485913.Krac_11292	5.032e-179	567.0	COG0859@1|root,COG0859@2|Bacteria,2G8F3@200795|Chloroflexi	200795|Chloroflexi	M	Glycosyltransferase family 9 (heptosyltransferase)	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_9
HKD2_k127_9022446_4	485913.Krac_11291	7.693e-48	181.0	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HKD2_k127_9022446_2	485913.Krac_11290	1.044e-166	535.0	COG0859@1|root,COG0859@2|Bacteria	2|Bacteria	M	ADP-heptose-lipopolysaccharide heptosyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_9
HKD2_k127_9025629_0	1382306.JNIM01000001_gene1006	1.588e-144	462.0	COG0788@1|root,COG0788@2|Bacteria,2GBGF@200795|Chloroflexi	200795|Chloroflexi	F	Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4)	purU	-	3.5.1.10	ko:K01433	ko00630,ko00670,map00630,map00670	-	R00944	RC00026,RC00111	ko00000,ko00001,ko01000	-	-	-	ACT,Formyl_trans_N
HKD2_k127_9025629_2	1382306.JNIM01000001_gene2477	1.137e-37	145.0	2ERSV@1|root,33JC2@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9025629_3	1123320.KB889716_gene7721	8.327e-06	50.0	COG3293@1|root,COG3293@2|Bacteria,2GMT0@201174|Actinobacteria	201174|Actinobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF4096
HKD2_k127_9025629_1	1382306.JNIM01000001_gene1621	9.059e-80	279.0	COG0515@1|root,COG0515@2|Bacteria	1382306.JNIM01000001_gene1621|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9034057_0	485913.Krac_1313	1.382e-270	856.0	COG0642@1|root,COG5002@1|root,COG2205@2|Bacteria,COG5002@2|Bacteria	2|Bacteria	T	protein histidine kinase activity	chvG	-	2.7.13.3	ko:K14980	ko02020,map02020	M00520	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,Sensor_TM1,Stimulus_sens_1
HKD2_k127_9034057_1	485913.Krac_1314	2.879e-105	345.0	COG1418@1|root,COG1418@2|Bacteria,2G77Y@200795|Chloroflexi	200795|Chloroflexi	S	PFAM metal-dependent phosphohydrolase, HD sub domain	-	-	-	ko:K06950	-	-	-	-	ko00000	-	-	-	HD
HKD2_k127_9034057_2	1382306.JNIM01000001_gene2470	2.483e-56	199.0	COG3427@1|root,COG3427@2|Bacteria	2|Bacteria	E	oxidoreductase activity, acting on CH-OH group of donors	-	-	-	-	-	-	-	-	-	-	-	-	COXG
HKD2_k127_9065494_1	1382306.JNIM01000001_gene2996	6.655e-15	76.0	COG2244@1|root,COG2244@2|Bacteria,2G6CM@200795|Chloroflexi	200795|Chloroflexi	S	Polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt,Polysacc_synt_C
HKD2_k127_9065494_0	485913.Krac_8056	2.184e-165	531.0	COG0726@1|root,COG0726@2|Bacteria,2G8HZ@200795|Chloroflexi	200795|Chloroflexi	G	Polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
HKD2_k127_9065494_2	1382306.JNIM01000001_gene1505	0.0004585	44.0	COG0745@1|root,COG0745@2|Bacteria	1382306.JNIM01000001_gene1505|-	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9068307_0	485913.Krac_6977	2.179e-38	163.0	COG2244@1|root,COG2244@2|Bacteria	2|Bacteria	S	polysaccharide biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt,Polysacc_synt_C
HKD2_k127_9097413_1	485913.Krac_11218	3.527e-48	177.0	COG2204@1|root,COG2204@2|Bacteria	2|Bacteria	T	phosphorelay signal transduction system	MA20_39160	-	-	ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	Response_reg
HKD2_k127_9097413_0	485913.Krac_11219	1.779e-82	280.0	COG0120@1|root,COG0120@2|Bacteria,2G6NN@200795|Chloroflexi	200795|Chloroflexi	G	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate	rpiA	-	5.3.1.6	ko:K01807	ko00030,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167,M00580	R01056	RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	Rib_5-P_isom_A
HKD2_k127_9097413_2	485913.Krac_11220	3.202e-18	86.0	COG4684@1|root,COG4684@2|Bacteria,2G79A@200795|Chloroflexi	200795|Chloroflexi	S	ECF transporter, substrate-specific component	-	-	-	-	-	-	-	-	-	-	-	-	ECF_trnsprt
HKD2_k127_9102337_1	485913.Krac_8458	1.392e-08	55.0	COG0288@1|root,COG0288@2|Bacteria,2G8Q4@200795|Chloroflexi	200795|Chloroflexi	P	Reversible hydration of carbon dioxide	-	-	-	-	-	-	-	-	-	-	-	-	Pro_CA
HKD2_k127_9102337_0	1382306.JNIM01000001_gene3316	3.734e-244	761.0	COG0473@1|root,COG0473@2|Bacteria,2G7RB@200795|Chloroflexi	200795|Chloroflexi	C	Isocitrate/isopropylmalate dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Iso_dh
HKD2_k127_9104383_3	485913.Krac_12325	4.314e-08	55.0	COG1695@1|root,COG1695@2|Bacteria	2|Bacteria	K	negative regulation of transcription, DNA-templated	-	-	-	-	-	-	-	-	-	-	-	-	PadR,Vir_act_alpha_C
HKD2_k127_9104383_1	485913.Krac_12182	7.308e-92	310.0	COG0454@1|root,COG0456@2|Bacteria,2G9G9@200795|Chloroflexi	200795|Chloroflexi	K	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HKD2_k127_9104383_2	485913.Krac_12181	1.278e-74	259.0	COG0671@1|root,COG0671@2|Bacteria,2G7F8@200795|Chloroflexi	200795|Chloroflexi	I	Acid phosphatase homologues	-	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2
HKD2_k127_9104383_0	485913.Krac_12178	3.042e-314	975.0	COG0465@1|root,COG0465@2|Bacteria,2G63X@200795|Chloroflexi	200795|Chloroflexi	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	-	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
HKD2_k127_9105147_0	485913.Krac_11955	8.473e-92	307.0	COG0653@1|root,COG0653@2|Bacteria,2G603@200795|Chloroflexi	200795|Chloroflexi	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
HKD2_k127_9108801_1	485913.Krac_12105	9.623e-134	429.0	COG0082@1|root,COG0082@2|Bacteria,2G645@200795|Chloroflexi	200795|Chloroflexi	E	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system	aroC	GO:0000166,GO:0003674,GO:0003824,GO:0004107,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0010181,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0032553,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050662,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	4.2.3.5	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01714	RC00586	ko00000,ko00001,ko00002,ko01000	-	-	-	Chorismate_synt
HKD2_k127_9108801_0	485913.Krac_12106	7.834e-136	446.0	COG1396@1|root,COG1396@2|Bacteria	2|Bacteria	K	sequence-specific DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
HKD2_k127_9110513_0	1122921.KB898207_gene3327	3.705e-64	232.0	COG0491@1|root,COG0491@2|Bacteria,1V8JE@1239|Firmicutes,4HIYW@91061|Bacilli,26VD8@186822|Paenibacillaceae	91061|Bacilli	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HKD2_k127_9147987_0	485913.Krac_7496	5.603e-238	754.0	COG4585@1|root,COG4585@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA_3
HKD2_k127_9149427_0	485913.Krac_1240	5.911e-84	293.0	COG1251@1|root,COG1251@2|Bacteria,2G6YZ@200795|Chloroflexi	200795|Chloroflexi	C	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	FHA,Pyr_redox_2
HKD2_k127_9149427_1	485913.Krac_1239	3.262e-40	150.0	COG1142@1|root,COG2905@1|root,COG1142@2|Bacteria,COG2905@2|Bacteria	2|Bacteria	T	signal-transduction protein containing cAMP-binding and CBS domains	ccpN	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	CBS,Fer4_7,GAF,GGDEF,HATPase_c,HTH_11,HisKA,PAS_3,PAS_4,PAS_9,Pyr_redox_2,Pyr_redox_3,Response_reg,cNMP_binding
HKD2_k127_915393_0	1382306.JNIM01000001_gene4189	6.072e-268	836.0	COG0664@1|root,COG0664@2|Bacteria,2G63K@200795|Chloroflexi	200795|Chloroflexi	T	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9165800_0	485913.Krac_7619	0.0	1482.0	COG1197@1|root,COG1197@2|Bacteria,2G5UW@200795|Chloroflexi	200795|Chloroflexi	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
HKD2_k127_9177385_0	485913.Krac_9685	2.39e-123	403.0	COG2898@1|root,COG2898@2|Bacteria	2|Bacteria	K	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms	mprF	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	2.3.2.3	ko:K07027,ko:K14205	ko01503,ko02020,ko05150,map01503,map02020,map05150	M00726	-	-	ko00000,ko00001,ko00002,ko01000,ko01504,ko02000	2.A.1.3.37,4.D.2	-	iYO844.BG12900	DUF2156,LPG_synthase_TM
HKD2_k127_9177385_2	485913.Krac_9684	4.913e-58	206.0	COG2246@1|root,COG2246@2|Bacteria	2|Bacteria	S	polysaccharide biosynthetic process	-	-	2.3.1.51,2.4.1.83	ko:K00655,ko:K00721	ko00510,ko00561,ko00564,ko01100,ko01110,map00510,map00561,map00564,map01100,map01110	M00089	R01009,R02241,R09381	RC00004,RC00005,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01003,ko01004	-	GT2	-	DUF4129,Glycos_transf_2,GtrA,Transglut_core
HKD2_k127_9177385_1	485913.Krac_3047	7.299e-120	400.0	COG2124@1|root,COG2124@2|Bacteria,2G7UC@200795|Chloroflexi	2|Bacteria	C	Cytochrome P450	eryK	GO:0000166,GO:0003674,GO:0003824,GO:0004497,GO:0005488,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016705,GO:0016709,GO:0016999,GO:0017000,GO:0017144,GO:0018130,GO:0019748,GO:0020037,GO:0030638,GO:0030639,GO:0033067,GO:0033068,GO:0036094,GO:0044237,GO:0044249,GO:0044550,GO:0046483,GO:0046906,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0097159,GO:1901265,GO:1901334,GO:1901336,GO:1901360,GO:1901362,GO:1901363,GO:1901576	1.14.13.154	ko:K14370	ko00522,ko01052,ko01130,map00522,map01052,map01130	M00774	R05521,R05522	RC01892	ko00000,ko00001,ko00002,ko00199,ko01000,ko01008	-	-	-	p450
HKD2_k127_9182556_0	485913.Krac_9802	3.613e-77	263.0	COG0237@1|root,COG0237@2|Bacteria,2G6RQ@200795|Chloroflexi	200795|Chloroflexi	F	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A	coaE	-	2.7.1.24	ko:K00859	ko00770,ko01100,map00770,map01100	M00120	R00130	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	CoaE
HKD2_k127_9182556_1	485913.Krac_9803	8.036e-58	205.0	COG0457@1|root,COG4249@1|root,COG0457@2|Bacteria,COG4249@2|Bacteria	2|Bacteria	S	B-1 B cell differentiation	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C14,WD40
HKD2_k127_9184507_1	390989.JOEG01000003_gene4699	2.141e-06	53.0	COG0543@1|root,COG1017@1|root,COG0543@2|Bacteria,COG1017@2|Bacteria,2GKXT@201174|Actinobacteria,4D9VT@85008|Micromonosporales	201174|Actinobacteria	C	Belongs to the globin family	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_6,Globin,NAD_binding_1
HKD2_k127_9184507_0	485913.Krac_9793	9.93e-87	296.0	COG0642@1|root,COG2205@2|Bacteria,2G6KS@200795|Chloroflexi	200795|Chloroflexi	T	histidine kinase A domain protein	-	-	2.7.13.3	ko:K07646	ko02020,map02020	M00454	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	DUF4118,GAF,HATPase_c,HisKA
HKD2_k127_9190635_0	485913.Krac_11073	0.0	1103.0	COG0749@1|root,COG0749@2|Bacteria,2G5J0@200795|Chloroflexi	200795|Chloroflexi	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	GO:0003674,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901362,GO:1901576	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
HKD2_k127_919651_0	1382306.JNIM01000001_gene2525	2.79e-184	583.0	COG0123@1|root,COG0123@2|Bacteria,2G5X3@200795|Chloroflexi	200795|Chloroflexi	BQ	PFAM histone deacetylase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
HKD2_k127_919651_2	485913.Krac_6707	1.439e-108	360.0	COG0454@1|root,COG0456@2|Bacteria,2G7CX@200795|Chloroflexi	200795|Chloroflexi	K	PFAM GCN5-related N-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HKD2_k127_919651_1	485913.Krac_6708	5.98e-169	538.0	COG0642@1|root,COG2114@1|root,COG2114@2|Bacteria,COG2205@2|Bacteria,2G6X8@200795|Chloroflexi	200795|Chloroflexi	T	adenylyl cyclase class-3 4 guanylyl cyclase	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	FHA,GAF_2,GAF_3,Guanylate_cyc,PAS
HKD2_k127_9211803_0	485913.Krac_7555	8.864e-309	949.0	COG0493@1|root,COG0493@2|Bacteria,2G82F@200795|Chloroflexi	200795|Chloroflexi	C	4fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Complex1_30kDa,Fer2_4,Fer4,Fer4_20,Pyr_redox_2
HKD2_k127_9213241_0	485913.Krac_9219	4.808e-159	511.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria	485913.Krac_9219|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9221069_1	1382306.JNIM01000001_gene4089	1.055e-171	542.0	COG2013@1|root,COG2013@2|Bacteria,2G7F5@200795|Chloroflexi	200795|Chloroflexi	S	Mitochondrial biogenesis AIM24	-	-	-	-	-	-	-	-	-	-	-	-	AIM24,zinc_ribbon_2
HKD2_k127_9221069_5	485913.Krac_12556	2.027e-118	384.0	COG0467@1|root,COG0467@2|Bacteria	2|Bacteria	T	regulation of circadian rhythm	-	-	-	-	-	-	-	-	-	-	-	-	AAA,AAA_25,MEDS
HKD2_k127_9221069_6	485913.Krac_12558	4.594e-72	248.0	COG0494@1|root,COG0494@2|Bacteria	2|Bacteria	L	nUDIX hydrolase	-	-	2.7.7.53,3.6.1.13,3.6.1.55	ko:K01515,ko:K03574,ko:K19710	ko00230,map00230	-	R00126,R01054,R01618	RC00002,RC02753,RC02795	ko00000,ko00001,ko01000,ko03400	-	-	-	NUDIX
HKD2_k127_9221069_2	1382306.JNIM01000001_gene4085	1.019e-155	496.0	COG0407@1|root,COG0407@2|Bacteria,2G6BE@200795|Chloroflexi	200795|Chloroflexi	H	PFAM Uroporphyrinogen decarboxylase (URO-D)	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
HKD2_k127_9221069_4	485913.Krac_12560	5.564e-135	432.0	COG0745@1|root,COG0745@2|Bacteria,2G5ND@200795|Chloroflexi	200795|Chloroflexi	K	Two component transcriptional regulator, winged helix family	-	-	-	ko:K07667,ko:K07668	ko02020,ko02024,map02020,map02024	M00454,M00459	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
HKD2_k127_9221069_0	1382306.JNIM01000001_gene4082	2.116e-210	666.0	COG5002@1|root,COG5002@2|Bacteria,2G66G@200795|Chloroflexi	200795|Chloroflexi	T	histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,GAF_3,HATPase_c,HisKA,PAS
HKD2_k127_9221069_3	485913.Krac_12562	2.851e-135	433.0	COG0336@1|root,COG0336@2|Bacteria,2G5MY@200795|Chloroflexi	200795|Chloroflexi	J	Belongs to the RNA methyltransferase TrmD family	trmD	GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050518,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.1.1.228	ko:K00554	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	tRNA_m1G_MT
HKD2_k127_9221069_7	485913.Krac_12563	1.366e-37	146.0	COG1674@1|root,COG1674@2|Bacteria,2G5XC@200795|Chloroflexi	200795|Chloroflexi	D	PFAM cell divisionFtsK SpoIIIE	-	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
HKD2_k127_9222933_0	63737.Npun_R1267	7.311e-148	477.0	COG0337@1|root,COG0337@2|Bacteria,1G2JF@1117|Cyanobacteria,1HKDQ@1161|Nostocales	1117|Cyanobacteria	E	3-dehydroquinate synthase	-	-	4.2.3.4	ko:K01735	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03083	RC00847	ko00000,ko00001,ko00002,ko01000	-	-	-	DHQ_synthase
HKD2_k127_9222933_3	1123368.AUIS01000014_gene2299	4.27e-27	113.0	2E5PI@1|root,330E7@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9222933_1	316274.Haur_1555	1.158e-139	447.0	COG1099@1|root,COG1099@2|Bacteria	2|Bacteria	S	hydrolase activity, acting on ester bonds	-	-	-	ko:K07051	-	-	-	-	ko00000	-	-	-	TatD_DNase
HKD2_k127_9222933_2	1121377.KB906432_gene912	1.405e-75	259.0	COG1082@1|root,COG1082@2|Bacteria,1WM6B@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	G	Xylose isomerase domain protein TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
HKD2_k127_9253571_1	485913.Krac_2277	9.554e-143	458.0	COG1403@1|root,COG1403@2|Bacteria	2|Bacteria	V	endonuclease activity	-	-	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	HNH,RRXRR
HKD2_k127_9253571_0	485913.Krac_10021	6.467e-165	549.0	COG0515@1|root,COG0515@2|Bacteria	485913.Krac_10021|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9262063_0	485913.Krac_7988	0.0	1476.0	COG1048@1|root,COG1048@2|Bacteria,2G5NG@200795|Chloroflexi	200795|Chloroflexi	C	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate	-	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
HKD2_k127_9275494_3	1382306.JNIM01000001_gene373	9.435e-14	75.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	NHL
HKD2_k127_9275494_1	1382306.JNIM01000001_gene2952	2.189e-47	174.0	COG0735@1|root,COG0735@2|Bacteria,2G74Y@200795|Chloroflexi	200795|Chloroflexi	P	Belongs to the Fur family	-	-	-	ko:K03711	-	-	-	-	ko00000,ko03000	-	-	-	FUR
HKD2_k127_9275494_4	485913.Krac_2627	2.218e-11	69.0	28XV3@1|root,2ZJRF@2|Bacteria	2|Bacteria	S	Phospholipase_D-nuclease N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	PLDc_N
HKD2_k127_9275494_0	1382306.JNIM01000001_gene1054	1.897e-91	308.0	COG1641@1|root,COG1641@2|Bacteria,2G5MP@200795|Chloroflexi	200795|Chloroflexi	S	Belongs to the LarC family	-	-	4.99.1.12	ko:K09121	-	-	-	-	ko00000,ko01000	-	-	-	DUF111
HKD2_k127_9275494_2	485913.Krac_8884	1.906e-15	79.0	COG2217@1|root,COG2217@2|Bacteria,2G5J7@200795|Chloroflexi	200795|Chloroflexi	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
HKD2_k127_928917_2	402777.KB235903_gene1217	5.764e-18	85.0	28KS2@1|root,2ZA9I@2|Bacteria,1G27K@1117|Cyanobacteria,1HA9W@1150|Oscillatoriales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_928917_0	1382306.JNIM01000001_gene3220	1.654e-197	623.0	COG5441@1|root,COG5441@2|Bacteria,2G7QM@200795|Chloroflexi	200795|Chloroflexi	S	Uncharacterised protein family (UPF0261)	-	-	-	-	-	-	-	-	-	-	-	-	UPF0261
HKD2_k127_928917_1	1382306.JNIM01000001_gene3219	2.449e-153	488.0	COG5564@1|root,COG5564@2|Bacteria,2G7PY@200795|Chloroflexi	200795|Chloroflexi	S	Phosphoenolpyruvate hydrolase-like	-	-	-	-	-	-	-	-	-	-	-	-	PEP_hydrolase
HKD2_k127_928917_3	1123276.KB893272_gene2436	0.0008835	45.0	COG3385@1|root,COG3385@2|Bacteria,4P02Y@976|Bacteroidetes,47TUA@768503|Cytophagia	976|Bacteroidetes	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
HKD2_k127_9290873_0	485913.Krac_10036	1.092e-228	714.0	COG0771@1|root,COG0771@2|Bacteria,2G5VE@200795|Chloroflexi	200795|Chloroflexi	M	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)	murD	-	6.3.2.9	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R02783	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase_C,Mur_ligase_M
HKD2_k127_9290873_2	1185876.BN8_02203	1.742e-09	62.0	2FBH3@1|root,343NG@2|Bacteria,4P60S@976|Bacteroidetes,47VSN@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9290873_1	215803.DB30_5187	1.184e-27	127.0	28WH1@1|root,2ZIH5@2|Bacteria,1Q9SQ@1224|Proteobacteria,439G6@68525|delta/epsilon subdivisions,2X4S4@28221|Deltaproteobacteria,2YZH4@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9296569_0	485913.Krac_11079	0.0	1371.0	COG1109@1|root,COG1208@1|root,COG1109@2|Bacteria,COG1208@2|Bacteria,2G65W@200795|Chloroflexi	200795|Chloroflexi	M	PFAM transferase hexapeptide repeat containing protein	-	-	2.7.7.13,5.4.2.8	ko:K16881	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114,M00362	R00885,R01818	RC00002,RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase,PGM_PMM_I,PGM_PMM_II,PGM_PMM_III
HKD2_k127_9296569_1	1382306.JNIM01000001_gene1226	7.086e-40	149.0	COG2442@1|root,COG2442@2|Bacteria	2|Bacteria	K	InterPro IPR007367	-	-	-	-	-	-	-	-	-	-	-	-	DUF433
HKD2_k127_9314920_5	485913.Krac_11730	2.552e-32	128.0	COG4187@1|root,COG4187@2|Bacteria	2|Bacteria	E	Peptidase family M20/M25/M40	rocB	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M20
HKD2_k127_9314920_0	1382306.JNIM01000001_gene1561	0.0	1639.0	COG0793@1|root,COG4946@1|root,COG0793@2|Bacteria,COG4946@2|Bacteria,2G64C@200795|Chloroflexi	200795|Chloroflexi	M	Tricorn protease homolog	-	-	-	ko:K08676	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PD40,Peptidase_S41,Tricorn_C1,Tricorn_PDZ
HKD2_k127_9314920_4	1382306.JNIM01000001_gene1472	1.574e-108	356.0	COG1321@1|root,COG1321@2|Bacteria,2G6N4@200795|Chloroflexi	200795|Chloroflexi	K	iron dependent repressor	-	-	-	ko:K03709	-	-	-	-	ko00000,ko03000	-	-	-	Fe_dep_repr_C,Fe_dep_repress,FeoA
HKD2_k127_9314920_3	485913.Krac_7828	9.045e-161	517.0	COG0438@1|root,COG0438@2|Bacteria,2G5PS@200795|Chloroflexi	200795|Chloroflexi	M	PFAM glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
HKD2_k127_9314920_1	1382306.JNIM01000001_gene895	4.542e-227	713.0	COG2148@1|root,COG2148@2|Bacteria,2G66B@200795|Chloroflexi	200795|Chloroflexi	M	PFAM sugar transferase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_transf,CoA_binding_3
HKD2_k127_9314920_2	1382306.JNIM01000001_gene894	3.138e-166	527.0	COG0438@1|root,COG0438@2|Bacteria,2G683@200795|Chloroflexi	200795|Chloroflexi	M	PFAM glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
HKD2_k127_9323980_1	485913.Krac_9241	9.755e-124	400.0	COG0745@1|root,COG0745@2|Bacteria,2G6A5@200795|Chloroflexi	200795|Chloroflexi	K	Two component transcriptional regulator, winged helix family	-	-	-	ko:K02483	-	-	-	-	ko00000,ko02022	-	-	-	Response_reg,Trans_reg_C
HKD2_k127_9323980_0	485913.Krac_9240	6.821e-126	409.0	COG1117@1|root,COG1117@2|Bacteria,2G646@200795|Chloroflexi	200795|Chloroflexi	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	pstB	GO:0003674,GO:0003824,GO:0005215,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015114,GO:0015318,GO:0015399,GO:0015405,GO:0015415,GO:0015698,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0034220,GO:0035435,GO:0042623,GO:0042626,GO:0043225,GO:0043492,GO:0051179,GO:0051234,GO:0055085,GO:0098656,GO:0098660,GO:0098661,GO:0099133	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
HKD2_k127_9323980_2	485913.Krac_9238	2.039e-72	249.0	COG0581@1|root,COG0581@2|Bacteria,2G8M9@200795|Chloroflexi	200795|Chloroflexi	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
HKD2_k127_9338594_1	1179778.PMM47T1_22812	5.612e-15	76.0	COG0714@1|root,COG0714@2|Bacteria,1MUFN@1224|Proteobacteria,1RN5G@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	PFAM ATPase associated with various cellular activities	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
HKD2_k127_9338594_0	485913.Krac_10245	2.274e-57	204.0	COG0330@1|root,COG0330@2|Bacteria,2G5SB@200795|Chloroflexi	200795|Chloroflexi	O	PFAM band 7 protein	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
HKD2_k127_9391017_0	395961.Cyan7425_2740	1.363e-108	359.0	COG1126@1|root,COG1126@2|Bacteria,1G2TD@1117|Cyanobacteria,3KGFR@43988|Cyanothece	1117|Cyanobacteria	E	PFAM ABC transporter related	-	-	3.6.3.21	ko:K02028	-	M00236	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.3	-	-	ABC_tran
HKD2_k127_9391017_1	485913.Krac_4641	2.555e-86	299.0	COG3595@1|root,COG3595@2|Bacteria,2G9KA@200795|Chloroflexi	200795|Chloroflexi	S	Putative adhesin	-	-	-	-	-	-	-	-	-	-	-	-	DUF4097
HKD2_k127_9406629_0	485913.Krac_12054	5.848e-279	880.0	COG0515@1|root,COG0515@2|Bacteria,2G5NM@200795|Chloroflexi	200795|Chloroflexi	KLT	Serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_6,Pkinase
HKD2_k127_9419899_3	272134.KB731324_gene5865	4.826e-09	59.0	COG0680@1|root,COG0680@2|Bacteria,1G5ZU@1117|Cyanobacteria,1HBCF@1150|Oscillatoriales	1117|Cyanobacteria	C	Hydrogenase maturation protease	-	-	-	-	-	-	-	-	-	-	-	-	HycI
HKD2_k127_9419899_0	247490.KSU1_A0077	1.903e-211	664.0	COG3259@1|root,COG3259@2|Bacteria,2IYS2@203682|Planctomycetes	203682|Planctomycetes	C	Nickel-dependent hydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	NiFeSe_Hases
HKD2_k127_9419899_1	518766.Rmar_2589	3.874e-120	390.0	COG1941@1|root,COG1941@2|Bacteria	2|Bacteria	C	coenzyme F420 hydrogenase activity	hoxY	-	-	-	-	-	-	-	-	-	-	-	Oxidored_q6
HKD2_k127_9419899_2	247490.KSU1_A0075	3.979e-115	377.0	COG0543@1|root,COG0543@2|Bacteria,2IYBB@203682|Planctomycetes	203682|Planctomycetes	C	Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B	-	-	-	-	-	-	-	-	-	-	-	-	DHODB_Fe-S_bind,FAD_binding_6,NAD_binding_1
HKD2_k127_9423361_3	485913.Krac_0633	1.473e-30	124.0	COG4274@1|root,COG4274@2|Bacteria	2|Bacteria	S	GYD domain	-	-	-	-	-	-	-	-	-	-	-	-	GYD
HKD2_k127_9423361_5	243274.THEMA_09295	2.255e-11	68.0	arCOG06877@1|root,32R18@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9423361_0	485913.Krac_5076	0.0	1035.0	COG0243@1|root,COG0243@2|Bacteria,2G5X7@200795|Chloroflexi	485913.Krac_5076|-	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9423361_1	485913.Krac_6859	2.574e-179	567.0	COG1186@1|root,COG1186@2|Bacteria,2G5P6@200795|Chloroflexi	200795|Chloroflexi	J	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA	prfB	-	-	ko:K02836	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
HKD2_k127_9426384_0	1122182.KB903838_gene3993	5.754e-50	187.0	COG1192@1|root,COG1192@2|Bacteria,2GJX3@201174|Actinobacteria,4DAR4@85008|Micromonosporales	201174|Actinobacteria	D	4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family	soj	GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0008150,GO:0009295,GO:0016020,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044424,GO:0044464,GO:0071944	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
HKD2_k127_9426384_1	1382306.JNIM01000001_gene1797	7.974e-31	124.0	COG3339@1|root,COG3339@2|Bacteria,2G7DT@200795|Chloroflexi	200795|Chloroflexi	S	Protein of unknown function (DUF1232)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1232
HKD2_k127_9428225_1	485913.Krac_6827	5.628e-29	122.0	COG1058@1|root,COG1058@2|Bacteria,2G6DU@200795|Chloroflexi	200795|Chloroflexi	S	PFAM molybdopterin binding domain	-	-	-	-	-	-	-	-	-	-	-	-	CinA,MoCF_biosynth
HKD2_k127_9428225_2	1298880.AUEV01000017_gene1145	1.237e-10	66.0	COG1546@1|root,COG1546@2|Bacteria,2IQ8T@201174|Actinobacteria	201174|Actinobacteria	I	Belongs to the CinA family	cinA	-	3.5.1.42	ko:K03743	ko00760,map00760	-	R02322	RC00100	ko00000,ko00001,ko01000	-	-	-	CinA
HKD2_k127_9428225_0	1382306.JNIM01000001_gene343	6.656e-145	469.0	COG0380@1|root,COG0380@2|Bacteria,2G6F8@200795|Chloroflexi	200795|Chloroflexi	G	PFAM glycosyl transferase family 20	-	-	2.4.1.15,2.4.1.347	ko:K00697	ko00500,ko01100,map00500,map01100	-	R02737	RC00005,RC00049,RC02748	ko00000,ko00001,ko01000,ko01003	-	GT20	-	Glyco_transf_20
HKD2_k127_9449060_0	485913.Krac_9005	6.046e-114	373.0	COG1975@1|root,COG1975@2|Bacteria,2G6H0@200795|Chloroflexi	200795|Chloroflexi	O	XdhC Rossmann domain	-	-	-	ko:K07402	-	-	-	-	ko00000	-	-	-	XdhC_C,XdhC_CoxI
HKD2_k127_9455473_3	485913.Krac_12186	4.203e-71	250.0	COG1716@1|root,COG1716@2|Bacteria	2|Bacteria	T	histone H2A K63-linked ubiquitination	-	-	-	ko:K21397	-	-	-	-	ko00000,ko02000	3.A.1	-	-	FHA,Yop-YscD_cpl
HKD2_k127_9455473_7	485913.Krac_9923	6.002e-16	87.0	COG3861@1|root,COG3861@2|Bacteria,2G9D9@200795|Chloroflexi	200795|Chloroflexi	S	Cation transport regulator	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9455473_0	485913.Krac_8759	2.9e-178	565.0	COG2170@1|root,COG2170@2|Bacteria,2G5NR@200795|Chloroflexi	200795|Chloroflexi	H	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity	-	-	-	ko:K06048	-	-	-	-	ko00000,ko01000	-	-	-	GCS2
HKD2_k127_9455473_4	1382306.JNIM01000001_gene326	3.02e-48	177.0	COG0295@1|root,COG0295@2|Bacteria,2G7AW@200795|Chloroflexi	200795|Chloroflexi	F	This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis	cdd	-	3.5.4.5	ko:K01489	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01878,R02485,R08221	RC00074,RC00514	ko00000,ko00001,ko01000	-	-	-	dCMP_cyt_deam_1
HKD2_k127_9455473_1	485913.Krac_12187	3.624e-135	432.0	COG0745@1|root,COG0745@2|Bacteria	485913.Krac_12187|-	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9455473_6	485913.Krac_12189	7.511e-30	120.0	COG3311@1|root,COG3311@2|Bacteria,2G7I6@200795|Chloroflexi	200795|Chloroflexi	L	TIGRFAM DNA binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_17
HKD2_k127_9459988_0	1382306.JNIM01000001_gene2626	1.341e-111	366.0	COG0351@1|root,COG0351@2|Bacteria,2G5R7@200795|Chloroflexi	200795|Chloroflexi	H	PFAM Phosphomethylpyrimidine kinase type-1	thiD	-	2.7.1.49,2.7.4.7	ko:K00941	ko00730,ko01100,map00730,map01100	M00127	R03471,R04509	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Phos_pyr_kin
HKD2_k127_9459988_1	1382306.JNIM01000001_gene2625	1.929e-106	351.0	COG2145@1|root,COG2145@2|Bacteria,2G7P5@200795|Chloroflexi	200795|Chloroflexi	F	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)	thiM	-	2.7.1.50	ko:K00878	ko00730,ko01100,map00730,map01100	M00127	R04448	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	HK
HKD2_k127_9459988_2	1382306.JNIM01000001_gene2624	7.851e-81	274.0	COG0352@1|root,COG0352@2|Bacteria,2G6P0@200795|Chloroflexi	200795|Chloroflexi	H	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)	thiE	GO:0003674,GO:0003824,GO:0004789,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.3	ko:K00788	ko00730,ko01100,map00730,map01100	M00127	R03223,R10712	RC00224,RC03255,RC03397	ko00000,ko00001,ko00002,ko01000	-	-	-	TMP-TENI
HKD2_k127_9463364_1	485913.Krac_10558	4.033e-53	190.0	COG3039@1|root,COG3039@2|Bacteria	2|Bacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
HKD2_k127_9463364_0	485913.Krac_10558	3.042e-133	436.0	COG3039@1|root,COG3039@2|Bacteria	2|Bacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
HKD2_k127_9469734_3	485913.Krac_7643	0.0003504	43.0	COG1266@1|root,COG1266@2|Bacteria	2|Bacteria	V	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
HKD2_k127_9469734_1	485913.Krac_7642	2.818e-61	218.0	2CKD9@1|root,333BQ@2|Bacteria,2G7BT@200795|Chloroflexi	200795|Chloroflexi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9469734_0	485913.Krac_7641	4.905e-250	780.0	COG0008@1|root,COG0008@2|Bacteria,2G5WU@200795|Chloroflexi	200795|Chloroflexi	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
HKD2_k127_9469734_2	485913.Krac_7640	2.483e-22	98.0	COG0019@1|root,COG0019@2|Bacteria,2G5RR@200795|Chloroflexi	200795|Chloroflexi	E	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine	lysA	-	4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
HKD2_k127_9472093_0	1382306.JNIM01000001_gene1098	1.026e-69	240.0	COG2268@1|root,COG2268@2|Bacteria,2G7FP@200795|Chloroflexi	200795|Chloroflexi	S	prohibitin homologues	-	-	-	-	-	-	-	-	-	-	-	-	Band_7,Flot
HKD2_k127_9472093_2	485913.Krac_11216	4.345e-48	183.0	COG1842@1|root,COG1842@2|Bacteria	2|Bacteria	KT	Phage shock protein A	-	-	-	ko:K03969	-	-	-	-	ko00000	-	-	-	PspA_IM30
HKD2_k127_9472093_1	485913.Krac_11218	1.757e-58	220.0	COG2204@1|root,COG2204@2|Bacteria	2|Bacteria	T	phosphorelay signal transduction system	MA20_39160	-	-	ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	Response_reg
HKD2_k127_947299_0	485913.Krac_2099	3.676e-269	831.0	COG0804@1|root,COG0804@2|Bacteria,2G63F@200795|Chloroflexi	200795|Chloroflexi	E	Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family	ureC	-	3.5.1.5	ko:K01428	ko00220,ko00230,ko00791,ko01100,ko01120,ko05120,map00220,map00230,map00791,map01100,map01120,map05120	-	R00131	RC02798,RC02806	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1,Urease_alpha
HKD2_k127_947299_5	485913.Krac_2098	5.811e-47	171.0	COG0832@1|root,COG0832@2|Bacteria,2G7HF@200795|Chloroflexi	200795|Chloroflexi	E	Belongs to the urease beta subunit family	ureB	-	3.5.1.5	ko:K01429	ko00220,ko00230,ko00791,ko01100,ko01120,map00220,map00230,map00791,map01100,map01120	-	R00131	RC02798,RC02806	ko00000,ko00001,ko01000	-	-	-	Urease_beta
HKD2_k127_947299_4	1128421.JAGA01000002_gene362	2.681e-47	171.0	COG0831@1|root,COG0831@2|Bacteria	2|Bacteria	E	urea catabolic process	ureA	-	3.5.1.5	ko:K01430	ko00220,ko00230,ko00791,ko01100,ko01120,map00220,map00230,map00791,map01100,map01120	-	R00131	RC02798,RC02806	ko00000,ko00001,ko01000	-	-	iSB619.SA_RS11965	Urease_gamma
HKD2_k127_947299_1	485913.Krac_2096	2.959e-92	312.0	COG0829@1|root,COG0829@2|Bacteria,2G6S1@200795|Chloroflexi	200795|Chloroflexi	O	Required for maturation of urease via the functional incorporation of the urease nickel metallocenter	ureD	-	-	ko:K03190	-	-	-	-	ko00000	-	-	-	UreD
HKD2_k127_947299_3	485913.Krac_2095	3.929e-66	233.0	COG0830@1|root,COG0830@2|Bacteria,2G6UX@200795|Chloroflexi	200795|Chloroflexi	O	Required for maturation of urease via the functional incorporation of the urease nickel metallocenter	ureF	-	-	ko:K03188	-	-	-	-	ko00000	-	-	-	UreF
HKD2_k127_947299_2	485913.Krac_3010	4.775e-79	269.0	COG1529@1|root,COG1529@2|Bacteria,2G608@200795|Chloroflexi	200795|Chloroflexi	C	aldehyde oxidase and xanthine dehydrogenase, a b hammerhead	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
HKD2_k127_9474994_0	1382306.JNIM01000001_gene407	1.623e-215	677.0	COG0486@1|root,COG0486@2|Bacteria,2G647@200795|Chloroflexi	200795|Chloroflexi	J	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34	mnmE	-	-	ko:K03650	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko01000,ko03016	-	-	-	MMR_HSR1,MnmE_helical,TrmE_N
HKD2_k127_9477144_1	1382306.JNIM01000001_gene2376	1.148e-271	843.0	COG0146@1|root,COG0146@2|Bacteria,2G644@200795|Chloroflexi	200795|Chloroflexi	EQ	PFAM Hydantoinase B oxoprolinase	-	-	3.5.2.14	ko:K01474	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydantoinase_B
HKD2_k127_9477144_0	485913.Krac_10143	6.088e-297	923.0	COG0145@1|root,COG0145@2|Bacteria,2G5KZ@200795|Chloroflexi	200795|Chloroflexi	EQ	Hydantoinaseoxoprolinase domain protein	-	-	3.5.2.14	ko:K01473	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydant_A_N,Hydantoinase_A
HKD2_k127_9508756_0	485913.Krac_6840	1.174e-68	239.0	COG2068@1|root,COG2068@2|Bacteria,2G6W9@200795|Chloroflexi	200795|Chloroflexi	S	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	-	-	2.7.7.76	ko:K07141	ko00790,map00790	-	R11582	-	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
HKD2_k127_9508756_2	1295642.H839_16413	1.186e-05	57.0	COG0671@1|root,COG0671@2|Bacteria,1VF2U@1239|Firmicutes,4HNXR@91061|Bacilli	91061|Bacilli	I	Membrane-associated phospholipid phosphatase	pgpB3	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2
HKD2_k127_9508756_1	485913.Krac_3326	3.724e-51	183.0	COG0675@1|root,COG0675@2|Bacteria	2|Bacteria	L	Transposase, IS605 OrfB family	-	-	-	ko:K07496	-	-	-	-	ko00000	-	-	-	HTH_OrfB_IS605,OrfB_IS605,OrfB_Zn_ribbon
HKD2_k127_9509977_0	485913.Krac_8851	4.44e-48	192.0	COG1470@1|root,COG1470@2|Bacteria	2|Bacteria	S	cell adhesion involved in biofilm formation	-	-	2.7.11.1	ko:K07004,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	ASH,DUF916,FHA,PG_binding_1,Pkinase
HKD2_k127_9510435_1	485913.Krac_11771	2.857e-12	72.0	28SAM@1|root,2ZEMQ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9534567_0	485913.Krac_1377	1.153e-141	460.0	COG0477@1|root,COG2814@2|Bacteria,2G71K@200795|Chloroflexi	200795|Chloroflexi	EGP	PFAM major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD2_k127_9574035_0	485913.Krac_7849	1.221e-174	556.0	COG0438@1|root,COG0438@2|Bacteria,2G5KS@200795|Chloroflexi	200795|Chloroflexi	M	PFAM glycosyl transferase group 1	-	-	2.4.1.250	ko:K15521	-	-	-	-	ko00000,ko01000	-	-	-	Glyco_transf_4,Glycos_transf_1
HKD2_k127_9574035_1	485913.Krac_7846	1.914e-54	192.0	2EAGR@1|root,334K0@2|Bacteria,2G730@200795|Chloroflexi	200795|Chloroflexi	S	PFAM zinc finger, SWIM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	SWIM
HKD2_k127_9578440_0	485913.Krac_8394	2.463e-267	827.0	COG0065@1|root,COG0065@2|Bacteria,2G68G@200795|Chloroflexi	200795|Chloroflexi	H	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	-	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
HKD2_k127_9578440_3	1382306.JNIM01000001_gene3353	3.747e-105	344.0	COG0066@1|root,COG0066@2|Bacteria,2G6JE@200795|Chloroflexi	200795|Chloroflexi	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	-	-	4.2.1.33,4.2.1.35	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R10170	RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase_C
HKD2_k127_9578440_2	485913.Krac_8391	2.351e-161	516.0	COG1071@1|root,COG1071@2|Bacteria,2G6HY@200795|Chloroflexi	200795|Chloroflexi	C	PFAM dehydrogenase, E1 component	-	-	-	-	-	-	-	-	-	-	-	-	E1_dh
HKD2_k127_9578440_1	485913.Krac_8390	3.678e-175	552.0	COG0022@1|root,COG0022@2|Bacteria,2G86C@200795|Chloroflexi	200795|Chloroflexi	C	PFAM Transketolase central region	-	-	1.2.4.4	ko:K00167	ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130	M00036	R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00027,RC00627,RC02743,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
HKD2_k127_9578997_2	485913.Krac_1187	8.233e-142	456.0	COG1171@1|root,COG1171@2|Bacteria,2G69F@200795|Chloroflexi	200795|Chloroflexi	E	PFAM Pyridoxal-5'-phosphate-dependent protein beta subunit	-	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HKD2_k127_9578997_0	485913.Krac_1190	2.575e-209	657.0	COG0151@1|root,COG0151@2|Bacteria,2G7M4@200795|Chloroflexi	200795|Chloroflexi	F	carboxylate-amine ligase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_4
HKD2_k127_9578997_3	485913.Krac_1192	6.44e-76	262.0	COG0546@1|root,COG0546@2|Bacteria	2|Bacteria	S	glycolate biosynthetic process	yjcH1	-	3.8.1.2	ko:K01560,ko:K07025	ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120	-	R05287	RC00697	ko00000,ko00001,ko01000	-	-	-	DUF3667,HAD_2
HKD2_k127_9578997_1	1385935.N836_00115	3.163e-160	522.0	COG3039@1|root,COG3039@2|Bacteria,1G3IA@1117|Cyanobacteria,1HEFE@1150|Oscillatoriales	1117|Cyanobacteria	L	Transposase domain (DUF772)	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_6,DUF772
HKD2_k127_9580151_2	497965.Cyan7822_5316	3.96e-20	92.0	COG1503@1|root,COG1503@2|Bacteria,1G29A@1117|Cyanobacteria,3KGPZ@43988|Cyanothece	1117|Cyanobacteria	J	translation release factor activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9580151_3	485913.Krac_3212	2.093e-18	86.0	2DEPM@1|root,2ZNRD@2|Bacteria,2G9FN@200795|Chloroflexi	200795|Chloroflexi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9580151_1	485913.Krac_11835	4.375e-66	232.0	COG1595@1|root,COG1595@2|Bacteria,2G6T5@200795|Chloroflexi	200795|Chloroflexi	K	PFAM sigma-70 region 2 domain protein	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD2_k127_9580151_0	1382306.JNIM01000001_gene592	1.149e-111	375.0	COG0248@1|root,COG0248@2|Bacteria,2G776@200795|Chloroflexi	200795|Chloroflexi	FP	PFAM Ppx GppA phosphatase	-	-	3.6.1.11,3.6.1.40	ko:K01524	ko00230,map00230	-	R03409	RC00002	ko00000,ko00001,ko01000	-	-	-	CHAD,HD,Ppx-GppA
HKD2_k127_9589653_1	485913.Krac_11220	1.063e-67	236.0	COG4684@1|root,COG4684@2|Bacteria,2G79A@200795|Chloroflexi	200795|Chloroflexi	S	ECF transporter, substrate-specific component	-	-	-	-	-	-	-	-	-	-	-	-	ECF_trnsprt
HKD2_k127_9589653_0	485913.Krac_11221	4.104e-97	321.0	COG1122@1|root,COG1122@2|Bacteria,2G5RY@200795|Chloroflexi	200795|Chloroflexi	P	PFAM ABC transporter related	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
HKD2_k127_9600664_2	485913.Krac_0606	1.313e-57	203.0	COG0675@1|root,COG0675@2|Bacteria	2|Bacteria	L	Transposase, IS605 OrfB family	-	-	-	ko:K07496	-	-	-	-	ko00000	-	-	-	OrfB_IS605,OrfB_Zn_ribbon
HKD2_k127_9600664_0	1382306.JNIM01000001_gene3877	2.957e-140	455.0	COG0682@1|root,COG0682@2|Bacteria,2G78M@200795|Chloroflexi	200795|Chloroflexi	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	lgt	-	-	ko:K13292	-	-	-	-	ko00000,ko01000	-	-	-	LGT
HKD2_k127_9613815_0	485913.Krac_10815	2.331e-224	699.0	COG0379@1|root,COG0379@2|Bacteria,2G64Y@200795|Chloroflexi	200795|Chloroflexi	H	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate	nadA	-	2.5.1.72	ko:K03517	ko00760,ko01100,map00760,map01100	M00115	R04292	RC01119	ko00000,ko00001,ko00002,ko01000	-	-	-	NadA
HKD2_k127_9613815_2	485913.Krac_10816	2.724e-115	380.0	COG0157@1|root,COG0157@2|Bacteria,2G6GJ@200795|Chloroflexi	200795|Chloroflexi	H	Belongs to the NadC ModD family	nadC	-	2.4.2.19	ko:K00767	ko00760,ko01100,map00760,map01100	M00115	R03348	RC02877	ko00000,ko00001,ko00002,ko01000	-	-	-	QRPTase_C,QRPTase_N
HKD2_k127_9613815_1	485913.Krac_2004	8.059e-213	673.0	COG0029@1|root,COG0029@2|Bacteria,2G5JM@200795|Chloroflexi	200795|Chloroflexi	H	Catalyzes the oxidation of L-aspartate to iminoaspartate	-	-	1.4.3.16	ko:K00278	ko00250,ko00760,ko01100,map00250,map00760,map01100	M00115	R00357,R00481	RC00006,RC02566	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
HKD2_k127_9618138_0	485913.Krac_12379	1.283e-98	326.0	COG2135@1|root,COG2135@2|Bacteria,2G74X@200795|Chloroflexi	200795|Chloroflexi	S	Belongs to the SOS response-associated peptidase family	-	-	-	-	-	-	-	-	-	-	-	-	SRAP
HKD2_k127_9618138_1	1382306.JNIM01000001_gene4	2.711e-56	205.0	COG1268@1|root,COG1268@2|Bacteria,2G71J@200795|Chloroflexi	200795|Chloroflexi	S	BioY family	-	-	-	-	-	-	-	-	-	-	-	-	BioY
HKD2_k127_9624043_2	485913.Krac_10089	1.635e-105	350.0	COG2326@1|root,COG2326@2|Bacteria,2G5UP@200795|Chloroflexi	200795|Chloroflexi	S	Polyphosphate kinase 2 (PPK2)	-	-	-	-	-	-	-	-	-	-	-	-	PPK2
HKD2_k127_9624043_1	485913.Krac_10089	1.709e-111	367.0	COG2326@1|root,COG2326@2|Bacteria,2G5UP@200795|Chloroflexi	200795|Chloroflexi	S	Polyphosphate kinase 2 (PPK2)	-	-	-	-	-	-	-	-	-	-	-	-	PPK2
HKD2_k127_9624043_0	485913.Krac_11142	2.748e-186	591.0	COG1232@1|root,COG1232@2|Bacteria,2G7T7@200795|Chloroflexi	200795|Chloroflexi	H	PFAM amine oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
HKD2_k127_9624043_3	1415779.JOMH01000001_gene2361	1.186e-61	220.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,1RMQ4@1236|Gammaproteobacteria,1X4ZP@135614|Xanthomonadales	135614|Xanthomonadales	IQ	AMP-binding enzyme C-terminal domain	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
HKD2_k127_9625588_5	1382306.JNIM01000001_gene3221	3.926e-30	120.0	COG0459@1|root,COG0459@2|Bacteria,2G65N@200795|Chloroflexi	200795|Chloroflexi	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0016465,GO:0032991,GO:0044183,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051082,GO:0061077,GO:0101031,GO:1990220	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
HKD2_k127_9625588_4	485913.Krac_11989	2.463e-47	171.0	COG0234@1|root,COG0234@2|Bacteria,2G784@200795|Chloroflexi	200795|Chloroflexi	O	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter	groS	-	-	ko:K04078	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Cpn10
HKD2_k127_9625588_3	485913.Krac_11993	1.495e-59	211.0	COG4770@1|root,COG4770@2|Bacteria	2|Bacteria	I	CoA carboxylase activity	pccA	-	6.4.1.3	ko:K01965,ko:K02160	ko00061,ko00280,ko00620,ko00630,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00280,map00620,map00630,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00373,M00376,M00741	R00742,R01859	RC00040,RC00097,RC00367,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2
HKD2_k127_9625588_0	485913.Krac_11995	2.453e-280	869.0	COG1884@1|root,COG1884@2|Bacteria,2G5TP@200795|Chloroflexi	200795|Chloroflexi	I	TIGRFAM methylmalonyl-CoA mutase, large subunit	-	-	5.4.99.2	ko:K01847,ko:K01848	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,MM_CoA_mutase
HKD2_k127_9625588_1	1382306.JNIM01000001_gene454	2.11e-95	321.0	COG0796@1|root,COG0796@2|Bacteria,2G8GN@200795|Chloroflexi	200795|Chloroflexi	M	Provides the (R)-glutamate required for cell wall biosynthesis	murI	-	5.1.1.3	ko:K01776	ko00471,ko01100,map00471,map01100	-	R00260	RC00302	ko00000,ko00001,ko01000,ko01011	-	-	-	Asp_Glu_race
HKD2_k127_9625588_2	485913.Krac_11998	2.328e-86	290.0	COG1005@1|root,COG1005@2|Bacteria,2G60S@200795|Chloroflexi	200795|Chloroflexi	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	nuoH	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
HKD2_k127_9633460_0	357808.RoseRS_0701	1.437e-53	197.0	COG4377@1|root,COG4377@2|Bacteria	2|Bacteria	S	Putative membrane peptidase family (DUF2324)	yhfC	-	-	-	-	-	-	-	-	-	-	-	DUF2324
HKD2_k127_9633460_1	1501230.ET33_33285	4.276e-46	175.0	COG0346@1|root,COG0346@2|Bacteria,1V77S@1239|Firmicutes,4HJC0@91061|Bacilli,26YZY@186822|Paenibacillaceae	91061|Bacilli	E	Ring-cleavage extradiol dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HKD2_k127_9634059_0	485913.Krac_2271	2.496e-147	474.0	COG0318@1|root,COG0318@2|Bacteria,2G66U@200795|Chloroflexi	200795|Chloroflexi	IQ	PFAM AMP-dependent synthetase and ligase	-	-	-	ko:K18661	ko00280,map00280	-	R03383	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C
HKD2_k127_9634059_1	1382306.JNIM01000001_gene1545	1.666e-24	111.0	COG2223@1|root,COG2223@2|Bacteria	2|Bacteria	P	nitrite transmembrane transporter activity	-	-	-	ko:K02575	ko00910,map00910	M00615	-	-	ko00000,ko00001,ko00002,ko02000	2.A.1.8	-	-	MFS_1
HKD2_k127_9639304_3	485913.Krac_10479	3.955e-59	209.0	COG0822@1|root,COG0822@2|Bacteria,2G6WC@200795|Chloroflexi	200795|Chloroflexi	C	NifU-like N terminal domain	-	-	-	ko:K04488	-	-	-	-	ko00000	-	-	-	NifU_N
HKD2_k127_9639304_1	485913.Krac_10480	9.096e-154	489.0	COG2897@1|root,COG2897@2|Bacteria,2G5XI@200795|Chloroflexi	200795|Chloroflexi	P	PFAM Rhodanese domain protein	-	-	2.8.1.1,2.8.1.2	ko:K01011	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko01000	-	-	-	Rhodanese
HKD2_k127_9639304_0	1382306.JNIM01000001_gene1583	6.096e-308	960.0	COG0507@1|root,COG0507@2|Bacteria,2G626@200795|Chloroflexi	200795|Chloroflexi	L	DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity	-	-	3.1.11.5	ko:K03581	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AAA_30,HHH_4,UvrD_C_2
HKD2_k127_9639304_2	485913.Krac_10483	1.187e-132	431.0	COG0457@1|root,COG3629@1|root,COG3899@1|root,COG0457@2|Bacteria,COG3629@2|Bacteria,COG3899@2|Bacteria,2G871@200795|Chloroflexi	200795|Chloroflexi	K	Transcriptional activator domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,BTAD,TPR_12
HKD2_k127_9660678_1	926569.ANT_11670	1.899e-69	243.0	COG0451@1|root,COG0451@2|Bacteria,2G64F@200795|Chloroflexi	200795|Chloroflexi	M	PFAM NAD-dependent epimerase dehydratase	-	-	4.1.1.35,4.2.1.46	ko:K01710,ko:K08678	ko00520,ko00521,ko00523,ko00525,ko01055,ko01100,ko01130,map00520,map00521,map00523,map00525,map01055,map01100,map01130	M00361,M00793	R01384,R06513	RC00402,RC00508	ko00000,ko00001,ko00002,ko01000	-	-	-	GDP_Man_Dehyd
HKD2_k127_9660678_0	485913.Krac_7276	7.675e-114	378.0	COG4552@1|root,COG4552@2|Bacteria,2G8CH@200795|Chloroflexi	200795|Chloroflexi	S	PFAM GCN5-related N-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_9,SCP2_2
HKD2_k127_9676475_2	485913.Krac_6699	4.236e-49	180.0	COG0205@1|root,COG0205@2|Bacteria,2G81H@200795|Chloroflexi	200795|Chloroflexi	H	Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions	pfp	-	2.7.1.11,2.7.1.90	ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
HKD2_k127_9676475_0	485913.Krac_6715	0.0	1017.0	COG1449@1|root,COG1449@2|Bacteria	2|Bacteria	G	Belongs to the glycosyl hydrolase 57 family	amyA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	2.4.1.25	ko:K22451	ko00500,map00500	-	R05196	RC00049	ko00000,ko00001,ko01000	-	GH57	-	DUF1925,DUF1926,Glyco_hydro_57
HKD2_k127_9676475_1	485913.Krac_6716	5.182e-69	243.0	COG0518@1|root,COG0518@2|Bacteria	2|Bacteria	F	GMP synthase (glutamine-hydrolyzing) activity	guaA2	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase
HKD2_k127_968744_1	485913.Krac_8284	1.538e-61	216.0	COG0839@1|root,COG0839@2|Bacteria,2G777@200795|Chloroflexi	200795|Chloroflexi	C	Belongs to the complex I subunit 6 family	-	-	1.6.5.3	ko:K00339	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q3
HKD2_k127_968744_2	485913.Krac_8283	3.272e-47	172.0	COG0713@1|root,COG0713@2|Bacteria,2G782@200795|Chloroflexi	200795|Chloroflexi	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoK	-	1.6.5.3	ko:K00340,ko:K05576	ko00190,ko01100,map00190,map01100	M00144,M00145	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q2
HKD2_k127_968744_0	485913.Krac_8282	1.47e-147	476.0	COG1009@1|root,COG1009@2|Bacteria,2G5NJ@200795|Chloroflexi	200795|Chloroflexi	CP	NADH-Ubiquinone oxidoreductase (complex I) chain 5 L domain protein	-	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M,Proton_antipo_N
HKD2_k127_9714852_0	485913.Krac_7551	5.52e-48	173.0	COG0626@1|root,COG0626@2|Bacteria,2G684@200795|Chloroflexi	200795|Chloroflexi	E	PFAM Cys Met metabolism	-	-	2.5.1.48,4.4.1.11	ko:K01739,ko:K01761	ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017	R00654,R00999,R01288,R02508,R03217,R03260,R04770,R04944,R04945,R04946	RC00020,RC00056,RC00069,RC00196,RC00348,RC00420,RC01209,RC01210,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000	-	-	-	Cys_Met_Meta_PP
HKD2_k127_9714852_1	485913.Krac_10059	6.704e-26	109.0	2E63U@1|root,330SV@2|Bacteria,2G9KB@200795|Chloroflexi	200795|Chloroflexi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9725425_0	485913.Krac_8619	7.851e-189	601.0	COG0642@1|root,COG0745@1|root,COG0745@2|Bacteria,COG2205@2|Bacteria	485913.Krac_8619|-	T	PhoQ Sensor	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9744806_3	485913.Krac_11442	1.665e-23	102.0	COG0580@1|root,COG0580@2|Bacteria	2|Bacteria	U	water channel activity	glpF	-	-	ko:K02440,ko:K06188,ko:K09874	-	-	-	-	ko00000,ko02000	1.A.8,1.A.8.1,1.A.8.12,1.A.8.2	-	-	MIP
HKD2_k127_9744806_2	485913.Krac_7290	4.546e-116	387.0	COG1295@1|root,COG1295@2|Bacteria,2G7DE@200795|Chloroflexi	200795|Chloroflexi	S	PFAM ribonuclease BN	-	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Virul_fac_BrkB
HKD2_k127_9744806_4	485913.Krac_9827	6.698e-14	75.0	arCOG13241@1|root,2ZEFN@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9744806_0	485913.Krac_8763	1.561e-228	715.0	COG0624@1|root,COG0624@2|Bacteria,2G5KY@200795|Chloroflexi	200795|Chloroflexi	E	peptidase dimerisation domain protein	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
HKD2_k127_9744806_1	485913.Krac_8762	2.146e-130	424.0	COG0624@1|root,COG0624@2|Bacteria,2G5IT@200795|Chloroflexi	200795|Chloroflexi	E	PFAM peptidase M20	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
HKD2_k127_9768731_1	1382306.JNIM01000001_gene131	4.62e-83	287.0	COG2010@1|root,COG2010@2|Bacteria,2G741@200795|Chloroflexi	200795|Chloroflexi	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Cytochrome_CBB3
HKD2_k127_9768731_2	485913.Krac_8613	2.768e-44	167.0	COG3088@1|root,COG3088@2|Bacteria,2G72W@200795|Chloroflexi	200795|Chloroflexi	O	subunit of a heme lyase	ccmH	-	-	ko:K02200	-	-	-	-	ko00000	-	-	-	CcmH
HKD2_k127_9768731_0	485913.Krac_8614	1.262e-102	338.0	COG1138@1|root,COG1138@2|Bacteria,2G5SZ@200795|Chloroflexi	200795|Chloroflexi	O	PFAM Cytochrome C assembly protein	ccmF	-	-	ko:K02198	-	-	-	-	ko00000,ko02000	9.B.14.1	-	-	CcmF_C,Cytochrom_C_asm
HKD2_k127_9775869_3	485913.Krac_12508	3.242e-110	359.0	COG0201@1|root,COG0201@2|Bacteria,2G5X4@200795|Chloroflexi	200795|Chloroflexi	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	-	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	SecY
HKD2_k127_9775869_4	1382306.JNIM01000001_gene3528	3.874e-95	316.0	COG0563@1|root,COG0563@2|Bacteria,2G6GP@200795|Chloroflexi	200795|Chloroflexi	F	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism	adk	-	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ADK,ADK_lid
HKD2_k127_9775869_8	1382306.JNIM01000001_gene3526	1.029e-36	139.0	COG0361@1|root,COG0361@2|Bacteria,2G7AQ@200795|Chloroflexi	200795|Chloroflexi	J	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex	infA	-	-	ko:K02518	-	-	-	-	ko00000,ko03012	-	-	-	eIF-1a
HKD2_k127_9775869_7	485913.Krac_12504	6.154e-65	224.0	COG0099@1|root,COG0099@2|Bacteria,2G6PF@200795|Chloroflexi	200795|Chloroflexi	J	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits	rpsM	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022613,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02952	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13
HKD2_k127_9775869_6	485913.Krac_12503	5.629e-74	249.0	COG0100@1|root,COG0100@2|Bacteria,2G6HG@200795|Chloroflexi	200795|Chloroflexi	J	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome	rpsK	-	-	ko:K02948	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S11
HKD2_k127_9775869_2	485913.Krac_12502	2.153e-113	367.0	COG0522@1|root,COG0522@2|Bacteria,2G6AZ@200795|Chloroflexi	200795|Chloroflexi	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit	rpsD	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0019222,GO:0019843,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S4,S4
HKD2_k127_9775869_0	485913.Krac_12501	1.922e-187	590.0	COG0202@1|root,COG0202@2|Bacteria,2G5M9@200795|Chloroflexi	200795|Chloroflexi	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA	GO:0003674,GO:0003824,GO:0003899,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576	2.7.7.6	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L
HKD2_k127_9775869_5	485913.Krac_12500	2.445e-91	306.0	COG0203@1|root,COG0203@2|Bacteria,2G79I@200795|Chloroflexi	200795|Chloroflexi	J	Ribosomal protein L17	rplQ	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02879	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L17
HKD2_k127_9775869_1	485913.Krac_12499	6.419e-127	410.0	COG0101@1|root,COG0101@2|Bacteria,2G6PE@200795|Chloroflexi	200795|Chloroflexi	J	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs	truA	GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016853,GO:0016866,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360	5.4.99.12	ko:K06173	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PseudoU_synth_1
HKD2_k127_9775869_9	485913.Krac_12498	1.029e-36	139.0	COG0102@1|root,COG0102@2|Bacteria,2G6M4@200795|Chloroflexi	200795|Chloroflexi	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly	rplM	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02871	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13
HKD2_k127_9787201_2	485913.Krac_8816	2.838e-59	210.0	2DSQB@1|root,33H1A@2|Bacteria	2|Bacteria	S	YGGT family	-	-	-	-	-	-	-	-	-	-	-	-	YGGT
HKD2_k127_9787201_0	1382306.JNIM01000001_gene3998	4.337e-191	612.0	COG3463@1|root,COG3463@2|Bacteria,2G8G9@200795|Chloroflexi	200795|Chloroflexi	S	Predicted membrane protein (DUF2079)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2079
HKD2_k127_9787201_1	1382306.JNIM01000001_gene3999	5.192e-92	306.0	COG1988@1|root,COG1988@2|Bacteria	2|Bacteria	NT	membrane-bound metal-dependent	ydjM	GO:0005575,GO:0005623,GO:0005886,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0031668,GO:0033554,GO:0044464,GO:0050896,GO:0051716,GO:0071496,GO:0071944	-	ko:K07038	-	-	-	-	ko00000	-	-	-	YdjM
HKD2_k127_9809775_2	485913.Krac_5033	3.237e-11	64.0	COG0842@1|root,COG0842@2|Bacteria,2G7XT@200795|Chloroflexi	200795|Chloroflexi	V	ABC-2 family transporter protein	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane
HKD2_k127_9809775_0	383372.Rcas_3731	1.452e-53	194.0	COG0757@1|root,COG0757@2|Bacteria,2G6N1@200795|Chloroflexi,3775Y@32061|Chloroflexia	32061|Chloroflexia	E	Catalyzes a trans-dehydration via an enolate intermediate	aroQ	-	4.2.1.10	ko:K03786	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03084	RC00848	ko00000,ko00001,ko00002,ko01000	-	-	-	DHquinase_II
HKD2_k127_9827615_2	485913.Krac_9965	5.151e-15	75.0	COG0118@1|root,COG0118@2|Bacteria,2G6FD@200795|Chloroflexi	200795|Chloroflexi	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR	hisH	-	-	ko:K02501	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
HKD2_k127_9827615_0	485913.Krac_9966	2.411e-292	916.0	COG0637@1|root,COG2334@1|root,COG0637@2|Bacteria,COG2334@2|Bacteria	2|Bacteria	S	homoserine kinase activity	phnX	GO:0003674,GO:0003824	2.6.1.37,3.1.3.18,3.11.1.1	ko:K01091,ko:K03430,ko:K05306	ko00440,ko00630,ko01100,ko01110,ko01120,ko01130,map00440,map00630,map01100,map01110,map01120,map01130	-	R00747,R01334,R04152	RC00008,RC00017,RC00062,RC00368	ko00000,ko00001,ko01000,ko01007	-	-	-	APH,HAD_2,Hydrolase
HKD2_k127_9827615_1	485913.Krac_9967	3.642e-162	516.0	COG0040@1|root,COG0040@2|Bacteria,2G6DD@200795|Chloroflexi	200795|Chloroflexi	F	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity	hisG	-	2.4.2.17	ko:K00765	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002,ko01000	-	-	-	HisG,HisG_C
HKD2_k127_983164_1	485913.Krac_9124	7.08e-91	302.0	COG0436@1|root,COG0436@2|Bacteria	2|Bacteria	E	Aminotransferase	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
HKD2_k127_983164_0	485913.Krac_9125	6.183e-182	573.0	COG0057@1|root,COG0057@2|Bacteria,2G5MG@200795|Chloroflexi	200795|Chloroflexi	C	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family	gap	-	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Gp_dh_C,Gp_dh_N
HKD2_k127_983164_2	485913.Krac_9126	5.488e-71	243.0	COG0126@1|root,COG0126@2|Bacteria,2G5UE@200795|Chloroflexi	200795|Chloroflexi	F	Belongs to the phosphoglycerate kinase family	pgk	-	2.7.2.3	ko:K00927	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01512	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
HKD2_k127_9863571_0	1382306.JNIM01000001_gene1512	9.285e-100	328.0	COG0346@1|root,COG0346@2|Bacteria	2|Bacteria	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HKD2_k127_9863571_1	485913.Krac_5625	6.409e-90	301.0	COG0400@1|root,COG0400@2|Bacteria,2G8M6@200795|Chloroflexi	200795|Chloroflexi	S	Phospholipase/Carboxylesterase	-	-	-	ko:K06999	-	-	-	-	ko00000	-	-	-	Abhydrolase_2
HKD2_k127_9863928_0	485913.Krac_10268	1.592e-107	350.0	COG1085@1|root,COG1085@2|Bacteria	2|Bacteria	C	galactose-1-phosphate uridylyltransferase	galT	-	2.7.7.12	ko:K00965	ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917	M00362,M00554,M00632	R00955	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	GalP_UDP_tr_C,GalP_UDP_transf
HKD2_k127_9863928_1	485913.Krac_10271	4.473e-90	303.0	COG0500@1|root,COG2226@2|Bacteria,2GA94@200795|Chloroflexi	200795|Chloroflexi	Q	Mycolic acid cyclopropane synthetase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
HKD2_k127_9885214_0	485913.Krac_8516	2.527e-226	714.0	COG2898@1|root,COG2898@2|Bacteria,2G6KJ@200795|Chloroflexi	200795|Chloroflexi	S	conserved protein (DUF2156)	-	-	2.3.2.3	ko:K14205	ko01503,ko02020,ko05150,map01503,map02020,map05150	M00726	-	-	ko00000,ko00001,ko00002,ko01000,ko01504	2.A.1.3.37	-	-	DUF2156,LPG_synthase_TM
HKD2_k127_9900145_0	485913.Krac_6047	6.252e-84	287.0	COG0768@1|root,COG0768@2|Bacteria,2G7V1@200795|Chloroflexi	200795|Chloroflexi	M	PFAM penicillin-binding protein transpeptidase	-	-	-	ko:K05364	ko00550,map00550	-	R04519	RC00005,RC00049	ko00000,ko00001,ko01011	-	-	-	Transpeptidase
HKD2_k127_9900145_1	485913.Krac_11802	3.726e-27	113.0	COG3832@1|root,COG3832@2|Bacteria,2G9IK@200795|Chloroflexi	200795|Chloroflexi	S	Polyketide cyclase / dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
HKD2_k127_9919256_1	1146883.BLASA_4264	1.517e-67	240.0	COG1526@1|root,COG1526@2|Bacteria,2GKWC@201174|Actinobacteria,4ES1V@85013|Frankiales	201174|Actinobacteria	C	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH	fdhD	-	-	ko:K02379	-	-	-	-	ko00000	-	-	-	FdhD-NarQ
HKD2_k127_9919256_2	1382306.JNIM01000001_gene405	3.807e-61	215.0	COG0735@1|root,COG0735@2|Bacteria,2G723@200795|Chloroflexi	200795|Chloroflexi	K	Belongs to the Fur family	-	-	-	ko:K03711	-	-	-	-	ko00000,ko03000	-	-	-	FUR
HKD2_k127_9919256_0	1382306.JNIM01000001_gene1207	1.337e-179	578.0	COG0768@1|root,COG0768@2|Bacteria,2G7V1@200795|Chloroflexi	200795|Chloroflexi	M	PFAM penicillin-binding protein transpeptidase	-	-	-	ko:K05364	ko00550,map00550	-	R04519	RC00005,RC00049	ko00000,ko00001,ko01011	-	-	-	Transpeptidase
HKD2_k127_992828_1	1382306.JNIM01000001_gene331	1.648e-140	449.0	COG2057@1|root,COG2057@2|Bacteria,2G6MS@200795|Chloroflexi	200795|Chloroflexi	I	Coenzyme A transferase	-	-	2.8.3.12	ko:K01040	ko00643,ko00650,ko01120,map00643,map00650,map01120	-	R04000,R05509	RC00012,RC00131,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
HKD2_k127_992828_0	485913.Krac_12470	9.604e-149	475.0	COG1788@1|root,COG1788@2|Bacteria,2G6IM@200795|Chloroflexi	200795|Chloroflexi	I	Coenzyme A transferase	-	-	2.8.3.12	ko:K01039	ko00643,ko00650,ko01120,map00643,map00650,map01120	-	R04000,R05509	RC00012,RC00131,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
HKD2_k127_9949675_0	1382306.JNIM01000001_gene1054	1.851e-79	280.0	COG1641@1|root,COG1641@2|Bacteria,2G5MP@200795|Chloroflexi	200795|Chloroflexi	S	Belongs to the LarC family	-	-	4.99.1.12	ko:K09121	-	-	-	-	ko00000,ko01000	-	-	-	DUF111
HKD2_k127_9949675_2	1226322.HMPREF1545_01946	5.909e-07	54.0	COG1595@1|root,COG1595@2|Bacteria,1V9ZH@1239|Firmicutes,25MR3@186801|Clostridia,2N8GB@216572|Oscillospiraceae	186801|Clostridia	K	ECF sigma factor	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD2_k127_9959091_1	485913.Krac_11799	1.2e-46	179.0	COG0457@1|root,COG0457@2|Bacteria	485913.Krac_11799|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9959091_0	485913.Krac_11801	3.354e-312	962.0	COG0129@1|root,COG0129@2|Bacteria,2G5QW@200795|Chloroflexi	200795|Chloroflexi	H	Belongs to the IlvD Edd family	ilvD	GO:0003674,GO:0003824,GO:0004160,GO:0016829,GO:0016835,GO:0016836	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
HKD2_k127_9959091_2	1382306.JNIM01000001_gene562	5.617e-17	84.0	COG3832@1|root,COG3832@2|Bacteria,2G9IK@200795|Chloroflexi	200795|Chloroflexi	S	Polyketide cyclase / dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
HKD2_k127_9966437_1	1382306.JNIM01000001_gene1561	2.218e-146	468.0	COG0793@1|root,COG4946@1|root,COG0793@2|Bacteria,COG4946@2|Bacteria,2G64C@200795|Chloroflexi	200795|Chloroflexi	M	Tricorn protease homolog	-	-	-	ko:K08676	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PD40,Peptidase_S41,Tricorn_C1,Tricorn_PDZ
HKD2_k127_9966437_0	485913.Krac_10528	1.032e-166	532.0	COG0402@1|root,COG0402@2|Bacteria	2|Bacteria	F	S-adenosylhomocysteine deaminase activity	hutF	-	3.5.3.13	ko:K05603	ko00340,map00340	-	R02286	RC00682	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
HKD2_k127_9970711_1	1144275.COCOR_00606	6.705e-27	113.0	COG2201@1|root,COG2201@2|Bacteria,1RCWE@1224|Proteobacteria,42S7B@68525|delta/epsilon subdivisions,2WNKM@28221|Deltaproteobacteria,2YZ8S@29|Myxococcales	28221|Deltaproteobacteria	NT	CheB methylesterase	-	-	3.1.1.61,3.5.1.44	ko:K03412	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest
HKD2_k127_9970711_0	1254432.SCE1572_26460	6.501e-145	481.0	COG1196@1|root,COG1352@1|root,COG2201@1|root,COG5002@1|root,COG1196@2|Bacteria,COG1352@2|Bacteria,COG2201@2|Bacteria,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria	1224|Proteobacteria	T	Histidine kinase	-	-	2.1.1.80,3.1.1.61	ko:K13924	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CHASE3,CheB_methylest,CheR,CheR_N,GAF,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg
HKD2_k127_997151_3	485913.Krac_1313	1.593e-23	104.0	COG0642@1|root,COG5002@1|root,COG2205@2|Bacteria,COG5002@2|Bacteria	2|Bacteria	T	protein histidine kinase activity	chvG	-	2.7.13.3	ko:K14980	ko02020,map02020	M00520	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,Sensor_TM1,Stimulus_sens_1
HKD2_k127_997151_0	485913.Krac_1311	3.374e-103	351.0	COG1295@1|root,COG1295@2|Bacteria,2G7DE@200795|Chloroflexi	200795|Chloroflexi	S	PFAM ribonuclease BN	-	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Virul_fac_BrkB
HKD2_k127_997151_2	485913.Krac_1310	2.622e-35	136.0	COG2214@1|root,COG2214@2|Bacteria	2|Bacteria	O	Heat shock protein DnaJ domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DNAJ_related,DnaJ
HKD2_k127_9985026_0	1382306.JNIM01000001_gene840	8.846e-43	167.0	COG1555@1|root,COG1555@2|Bacteria,2G771@200795|Chloroflexi	200795|Chloroflexi	L	TIGRFAM competence protein ComEA helix-hairpin-helix repeat protein	comEA	-	-	ko:K02237	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	HHH_3,SLBB
## 2859 queries scanned
## Total time (seconds): 34.75374126434326
## Rate: 82.26 q/s