## Sat Nov 16 10:18:01 2024
## emapper-2.1.12
## /data/home/zkh/miniconda3/envs/eggnog-mapper/bin/emapper.py -i /data/home/zkh/binning/bin_4635/bin/bin8/HKD_2_bin.30.fa -m mmseqs --itype genome -o HKD_2_bin.30 --output_dir /data/home/zkh/meta_analysis/eggnog-mapper/4635/HKD_2_bin.30 --cpu 28
##
#query	seed_ortholog	evalue	score	eggNOG_OGs	max_annot_lvl	COG_category	Description	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	PFAMs
HKD2_k127_10000605_1	1121403.AUCV01000008_gene1631	1.247e-39	148.0	COG0209@1|root,COG0209@2|Bacteria	2|Bacteria	F	ribonucleoside-diphosphate reductase activity	-	-	1.17.4.1	ko:K00525,ko:K00526	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	ATP-cone,Ribonuc_red_lgC,Ribonuc_red_lgN
HKD2_k127_10000605_2	935863.AWZR01000014_gene2989	1.311e-08	61.0	2EHSB@1|root,33BI2@2|Bacteria	2|Bacteria	S	SdpI/YhfL protein family	-	-	-	-	-	-	-	-	-	-	-	-	SdpI
HKD2_k127_10000605_0	1167006.UWK_03298	1.168e-48	179.0	COG0558@1|root,COG0558@2|Bacteria,1P9BV@1224|Proteobacteria,432CD@68525|delta/epsilon subdivisions,2WX7J@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	-	-	2.7.8.41,2.7.8.5	ko:K00995,ko:K08744	ko00564,ko01100,map00564,map01100	-	R01801,R02030	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
HKD2_k127_10000605_3	1121091.AUMP01000006_gene4105	2.343e-06	51.0	2DTBP@1|root,33JKJ@2|Bacteria,1VKDH@1239|Firmicutes,4I0AV@91061|Bacilli	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_10008632_2	644282.Deba_3077	1.072e-37	163.0	COG0392@1|root,COG0392@2|Bacteria	2|Bacteria	M	lysyltransferase activity	-	-	-	ko:K07027	-	-	-	-	ko00000,ko02000	4.D.2	-	-	LPG_synthase_TM
HKD2_k127_10008632_1	1167006.UWK_02613	2.789e-61	237.0	COG0823@1|root,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	LysM,PD40
HKD2_k127_10008632_0	1304885.AUEY01000002_gene324	2.778e-92	320.0	COG1032@1|root,COG1032@2|Bacteria,1NRWP@1224|Proteobacteria,42S72@68525|delta/epsilon subdivisions,2WNA6@28221|Deltaproteobacteria,2MKAP@213118|Desulfobacterales	28221|Deltaproteobacteria	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
HKD2_k127_10015730_0	1121918.ARWE01000001_gene403	1.52e-214	678.0	COG3261@1|root,COG3262@1|root,COG3261@2|Bacteria,COG3262@2|Bacteria,1QUBF@1224|Proteobacteria,42NJH@68525|delta/epsilon subdivisions,2WJ6J@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Respiratory-chain NADH dehydrogenase, 49 Kd subunit	-	-	-	-	-	-	-	-	-	-	-	-	Complex1_30kDa,Complex1_49kDa,NiFeSe_Hases
HKD2_k127_10021095_6	1485545.JQLW01000007_gene665	8.251e-121	394.0	COG0225@1|root,COG0229@1|root,COG0225@2|Bacteria,COG0229@2|Bacteria,1RGWC@1224|Proteobacteria	1224|Proteobacteria	O	methionine sulfoxide reductase	msrB	-	1.8.4.11,1.8.4.12	ko:K07305,ko:K12267	-	-	-	-	ko00000,ko01000	-	-	-	PMSR,SelR
HKD2_k127_10021095_7	871968.DESME_15100	4.243e-120	404.0	COG1629@1|root,COG2247@1|root,COG3391@1|root,COG2247@2|Bacteria,COG3391@2|Bacteria,COG4771@2|Bacteria,1V0RA@1239|Firmicutes,24AV7@186801|Clostridia,260Q2@186807|Peptococcaceae	186801|Clostridia	EM	cell wall binding repeat 2	-	-	-	-	-	-	-	-	-	-	-	-	CW_binding_2,Lipase_GDSL_2,TIG
HKD2_k127_10021095_16	1173026.Glo7428_4661	3.68e-33	134.0	COG1846@1|root,COG1846@2|Bacteria,1G6XI@1117|Cyanobacteria	1117|Cyanobacteria	K	MarR family transcriptional	-	-	-	ko:K15973	-	-	-	-	ko00000,ko03000	-	-	-	MarR
HKD2_k127_10021095_14	1122214.AQWH01000009_gene1953	2.124e-62	219.0	COG2110@1|root,COG2110@2|Bacteria,1RCWP@1224|Proteobacteria,2U70V@28211|Alphaproteobacteria,2PKZC@255475|Aurantimonadaceae	28211|Alphaproteobacteria	S	Appr-1'-p processing enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Macro
HKD2_k127_10021095_15	402881.Plav_0507	7.411e-62	228.0	COG5309@1|root,COG5309@2|Bacteria	2|Bacteria	G	chondroitin AC lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_10021095_5	443143.GM18_2338	3.335e-141	473.0	COG0501@1|root,COG0501@2|Bacteria,1MVU4@1224|Proteobacteria,42PSI@68525|delta/epsilon subdivisions,2WJQG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	PFAM peptidase M48 Ste24p	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
HKD2_k127_10021095_11	1249627.D779_1601	7.794e-72	248.0	COG1704@1|root,COG1704@2|Bacteria,1MVH0@1224|Proteobacteria,1RP1N@1236|Gammaproteobacteria,1WWRQ@135613|Chromatiales	135613|Chromatiales	S	LemA family	-	-	-	ko:K03744	-	-	-	-	ko00000	-	-	-	LemA
HKD2_k127_10021095_0	765914.ThisiDRAFT_2078	7.178e-225	711.0	COG0659@1|root,COG0659@2|Bacteria,1MWDF@1224|Proteobacteria,1SYC8@1236|Gammaproteobacteria,1WWSA@135613|Chromatiales	135613|Chromatiales	U	sulphate transporter	-	-	-	ko:K03321	-	-	-	-	ko00000,ko02000	2.A.53.3	-	-	STAS,Sulfate_transp
HKD2_k127_10021095_9	589865.DaAHT2_1045	4.574e-93	316.0	COG2006@1|root,COG2006@2|Bacteria,1R9FE@1224|Proteobacteria,42QMT@68525|delta/epsilon subdivisions,2WKDC@28221|Deltaproteobacteria,2MJW3@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
HKD2_k127_10021095_10	589865.DaAHT2_1376	2.637e-91	316.0	COG1924@1|root,COG1924@2|Bacteria	2|Bacteria	I	4 iron, 4 sulfur cluster binding	yjiL	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG
HKD2_k127_10021095_8	1167006.UWK_02094	4.041e-96	320.0	2CK5J@1|root,34791@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_10021095_4	1121403.AUCV01000001_gene877	1.391e-153	493.0	COG0795@1|root,COG0795@2|Bacteria,1MVW3@1224|Proteobacteria,42N5X@68525|delta/epsilon subdivisions,2WJ3H@28221|Deltaproteobacteria,2MI77@213118|Desulfobacterales	28221|Deltaproteobacteria	S	permease YjgP YjgQ family	lptG	-	-	ko:K11720	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko02000	1.B.42.1	-	-	YjgP_YjgQ
HKD2_k127_10021095_2	1167006.UWK_02097	1.023e-177	572.0	COG3894@1|root,COG3894@2|Bacteria,1MX9D@1224|Proteobacteria,42PW1@68525|delta/epsilon subdivisions,2WJZD@28221|Deltaproteobacteria,2MHZX@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Domain of unknown function (DUF4445)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4445
HKD2_k127_10021095_3	1121403.AUCV01000001_gene878	4.119e-166	528.0	COG0618@1|root,COG0618@2|Bacteria,1N0JS@1224|Proteobacteria,42P1S@68525|delta/epsilon subdivisions,2WJV0@28221|Deltaproteobacteria,2MI7M@213118|Desulfobacterales	28221|Deltaproteobacteria	S	PFAM phosphoesterase RecJ domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DHH,DHHA1
HKD2_k127_10021095_1	1232410.KI421422_gene2081	1.296e-219	702.0	COG0826@1|root,COG0826@2|Bacteria,1MUQG@1224|Proteobacteria,42M8P@68525|delta/epsilon subdivisions,2X5K8@28221|Deltaproteobacteria,43SE1@69541|Desulfuromonadales	28221|Deltaproteobacteria	O	Collagenase	-	-	-	ko:K08303	ko05120,map05120	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	DUF3656,Peptidase_U32
HKD2_k127_10021095_12	1167006.UWK_01822	4.876e-68	241.0	COG0101@1|root,COG0101@2|Bacteria,1MUYI@1224|Proteobacteria,42RTC@68525|delta/epsilon subdivisions,2WNQ6@28221|Deltaproteobacteria,2MJMQ@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs	truA	-	5.4.99.12	ko:K06173	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PseudoU_synth_1
HKD2_k127_10021095_13	1499967.BAYZ01000159_gene484	1.167e-63	229.0	COG0598@1|root,COG0598@2|Bacteria,2NPAW@2323|unclassified Bacteria	2|Bacteria	P	CorA-like Mg2+ transporter protein	corA	-	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
HKD2_k127_10055870_1	926569.ANT_04770	3.658e-42	161.0	COG2909@1|root,COG3629@1|root,COG2909@2|Bacteria,COG3629@2|Bacteria,2G6RU@200795|Chloroflexi	200795|Chloroflexi	K	Transcriptional activator domain	-	-	-	-	-	-	-	-	-	-	-	-	BTAD,TPR_12
HKD2_k127_10055870_0	926569.ANT_30270	7.838e-174	554.0	COG0673@1|root,COG1063@1|root,COG0673@2|Bacteria,COG1063@2|Bacteria,2G75J@200795|Chloroflexi	200795|Chloroflexi	C	PFAM Alcohol dehydrogenase zinc-binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
HKD2_k127_10058341_1	1167006.UWK_02807	1.078e-43	161.0	COG0261@1|root,COG0261@2|Bacteria,1MZEW@1224|Proteobacteria,42SGM@68525|delta/epsilon subdivisions,2WQ3I@28221|Deltaproteobacteria,2MKN7@213118|Desulfobacterales	28221|Deltaproteobacteria	J	This protein binds to 23S rRNA in the presence of protein L20	rplU	GO:0003674,GO:0003735,GO:0005198	-	ko:K02888	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L21p
HKD2_k127_10058341_2	177439.DP2591	3.562e-41	153.0	COG0211@1|root,COG0211@2|Bacteria,1MZGH@1224|Proteobacteria,42THK@68525|delta/epsilon subdivisions,2WQ2U@28221|Deltaproteobacteria,2MKMM@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Belongs to the bacterial ribosomal protein bL27 family	rpmA	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02899	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27
HKD2_k127_10058341_0	1121403.AUCV01000010_gene1394	3.093e-140	452.0	COG0536@1|root,COG0536@2|Bacteria,1MUGZ@1224|Proteobacteria,42M40@68525|delta/epsilon subdivisions,2WIM4@28221|Deltaproteobacteria,2MI7D@213118|Desulfobacterales	28221|Deltaproteobacteria	S	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control	obg	-	-	ko:K03979	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	GTP1_OBG,MMR_HSR1
HKD2_k127_10058341_4	1121403.AUCV01000010_gene1395	4.815e-14	72.0	COG0263@1|root,COG0263@2|Bacteria,1MUBG@1224|Proteobacteria,42NEA@68525|delta/epsilon subdivisions,2WIVS@28221|Deltaproteobacteria,2MHN5@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate	proB	GO:0003674,GO:0003824,GO:0004349,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0018130,GO:0019202,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.2.11	ko:K00931	ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230	M00015	R00239	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_3198	AA_kinase,PUA
HKD2_k127_10070283_2	1499967.BAYZ01000016_gene6532	2.44e-24	107.0	COG1196@1|root,COG1361@1|root,COG5301@1|root,COG5306@1|root,COG1196@2|Bacteria,COG1361@2|Bacteria,COG5301@2|Bacteria,COG5306@2|Bacteria	2|Bacteria	G	cellulose 1,4-beta-cellobiosidase activity	exbB2	-	3.4.14.5,4.2.2.1	ko:K01278,ko:K01727,ko:K03561,ko:K12287,ko:K21449	ko04974,map04974	-	-	-	ko00000,ko00001,ko01000,ko01002,ko02000,ko02044,ko04090,ko04147	1.A.30.2.1,1.B.40.2	PL8	-	DUF2341,Laminin_G_3,MotA_ExbB
HKD2_k127_10070283_3	391625.PPSIR1_04888	2.876e-11	75.0	COG0500@1|root,COG2226@2|Bacteria,1RC36@1224|Proteobacteria,42UDA@68525|delta/epsilon subdivisions,2WQHW@28221|Deltaproteobacteria,2YV8X@29|Myxococcales	28221|Deltaproteobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
HKD2_k127_10070283_0	269799.Gmet_0591	2.211e-56	217.0	COG3420@1|root,COG3420@2|Bacteria	2|Bacteria	P	alginic acid biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,CBM_35,CBM_6,He_PIG,Malectin
HKD2_k127_10092143_0	1121403.AUCV01000034_gene3852	1.214e-226	706.0	COG0553@1|root,COG0553@2|Bacteria,1MV6M@1224|Proteobacteria,42M5P@68525|delta/epsilon subdivisions,2WIW8@28221|Deltaproteobacteria,2MIH9@213118|Desulfobacterales	28221|Deltaproteobacteria	L	SNF2 family N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Helicase_C,SNF2_N,SNF2_assoc
HKD2_k127_10092143_1	177439.DP1282	7.558e-28	116.0	COG0141@1|root,COG0141@2|Bacteria,1MUUF@1224|Proteobacteria,42M3R@68525|delta/epsilon subdivisions,2WJGT@28221|Deltaproteobacteria,2MICP@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine	hisD	GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.1.1.23	ko:K00013	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01158,R01163,R03012	RC00099,RC00242,RC00463	ko00000,ko00001,ko00002,ko01000	-	-	-	Histidinol_dh
HKD2_k127_10100308_1	342949.PNA2_1339	2.039e-28	115.0	COG0129@1|root,arCOG04045@2157|Archaea,2XSW2@28890|Euryarchaeota,243UC@183968|Thermococci	183968|Thermococci	E	Belongs to the IlvD Edd family	ilvD	-	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
HKD2_k127_10100308_0	880072.Desac_0483	3.52e-131	431.0	COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,42M5E@68525|delta/epsilon subdivisions,2WIV6@28221|Deltaproteobacteria,2MQWY@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	TIGRFAM ribonuclease, Rne Rng family	rne	-	3.1.26.12	ko:K08300,ko:K08301	ko03018,map03018	M00394	-	-	ko00000,ko00001,ko00002,ko01000,ko03009,ko03019	-	-	-	RNase_E_G,S1
HKD2_k127_10144754_1	1121405.dsmv_0459	2.638e-55	206.0	COG3031@1|root,COG3031@2|Bacteria,1PUWN@1224|Proteobacteria,42T73@68525|delta/epsilon subdivisions,2WPQU@28221|Deltaproteobacteria,2MK5Q@213118|Desulfobacterales	28221|Deltaproteobacteria	U	General secretion pathway protein C	gspC	-	-	ko:K02452	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	PDZ_2,T2SSC
HKD2_k127_10144754_0	177437.HRM2_11310	2.412e-187	606.0	COG1450@1|root,COG4796@1|root,COG1450@2|Bacteria,COG4796@2|Bacteria,1MUUA@1224|Proteobacteria,42M9I@68525|delta/epsilon subdivisions,2WK1H@28221|Deltaproteobacteria,2MIEH@213118|Desulfobacterales	28221|Deltaproteobacteria	NU	type II and III secretion system protein	gspD	-	-	ko:K02453	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	Secretin,Secretin_N
HKD2_k127_10144754_2	1121405.dsmv_0457	1.502e-23	106.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,42M51@68525|delta/epsilon subdivisions,2WIPP@28221|Deltaproteobacteria,2MHPE@213118|Desulfobacterales	28221|Deltaproteobacteria	NU	type II secretion system protein E	gspE	-	-	ko:K02454	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSE,T2SSE_N
HKD2_k127_10156686_1	1121403.AUCV01000008_gene1531	1.716e-279	881.0	COG0038@1|root,COG0517@1|root,COG0038@2|Bacteria,COG0517@2|Bacteria,1MV4K@1224|Proteobacteria,42N93@68525|delta/epsilon subdivisions,2WJ9N@28221|Deltaproteobacteria,2MHX8@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Voltage gated chloride channel	-	-	-	ko:K03281	-	-	-	-	ko00000	2.A.49	-	-	CBS,TrkA_C,Voltage_CLC
HKD2_k127_10156686_3	1167006.UWK_02397	1.121e-150	490.0	COG0232@1|root,COG0232@2|Bacteria,1R6QQ@1224|Proteobacteria,42M0H@68525|delta/epsilon subdivisions,2WJ33@28221|Deltaproteobacteria,2MHN1@213118|Desulfobacterales	28221|Deltaproteobacteria	F	SMART metal-dependent phosphohydrolase HD region	-	-	3.1.5.1	ko:K01129	ko00230,map00230	-	R01856	RC00017	ko00000,ko00001,ko01000	-	-	-	HD,HD_assoc
HKD2_k127_10156686_6	1121403.AUCV01000008_gene1529	5.077e-14	73.0	291UZ@1|root,2ZPES@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_10156686_4	1167006.UWK_00589	1.153e-105	373.0	COG2204@1|root,COG4191@1|root,COG2204@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MC4@68525|delta/epsilon subdivisions,2WIZU@28221|Deltaproteobacteria,2MJ29@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg,SBP_bac_3,dCache_3
HKD2_k127_10156686_2	589865.DaAHT2_0244	6.51e-168	548.0	COG0115@1|root,COG0147@1|root,COG0115@2|Bacteria,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,42P55@68525|delta/epsilon subdivisions,2WKYQ@28221|Deltaproteobacteria,2MPWZ@213118|Desulfobacterales	28221|Deltaproteobacteria	EH	chorismate binding enzyme	pabB	-	2.6.1.85,4.1.3.38	ko:K01665,ko:K03342	ko00790,map00790	-	R01716,R05553	RC00010,RC01418,RC01843,RC02148	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_4,Chorismate_bind
HKD2_k127_10156686_5	1167006.UWK_03470	4.318e-94	314.0	COG0517@1|root,COG0517@2|Bacteria,1RA25@1224|Proteobacteria,42R80@68525|delta/epsilon subdivisions,2WMW6@28221|Deltaproteobacteria,2MKBU@213118|Desulfobacterales	28221|Deltaproteobacteria	S	PFAM CBS domain containing protein	-	-	-	ko:K04767	-	-	-	-	ko00000	-	-	-	CBS
HKD2_k127_10156686_0	1121403.AUCV01000008_gene1528	0.0	1911.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1145@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1145@2|Bacteria,1MVM0@1224|Proteobacteria,42MZ0@68525|delta/epsilon subdivisions,2WJ96@28221|Deltaproteobacteria,2MHRJ@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	poR	-	1.2.7.1	ko:K03737	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00173,M00307	R01196,R10866	RC00004,RC02742	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	EKR,Fer4_16,PFOR_II,POR,POR_N,TPP_enzyme_C
HKD2_k127_10168451_1	1232410.KI421414_gene2815	3.519e-194	631.0	COG0421@1|root,COG0421@2|Bacteria,1P220@1224|Proteobacteria,42NG6@68525|delta/epsilon subdivisions,2WIRU@28221|Deltaproteobacteria,43TQY@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	-	-	-	-	-	-	-	-	-	-	-	-	Spermine_synth
HKD2_k127_10168451_3	1232410.KI421414_gene2816	3.048e-81	278.0	COG2518@1|root,COG2518@2|Bacteria,1MXQC@1224|Proteobacteria,42QXM@68525|delta/epsilon subdivisions,2WMZI@28221|Deltaproteobacteria,43W1B@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	pcm	-	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
HKD2_k127_10168451_2	56110.Oscil6304_1573	5.075e-141	461.0	COG2270@1|root,COG2270@2|Bacteria,1G3YB@1117|Cyanobacteria,1HA0N@1150|Oscillatoriales	1117|Cyanobacteria	S	Vacuole effluxer Atg22 like	-	-	-	ko:K06902	ko04138,map04138	-	-	-	ko00000,ko00001,ko02000,ko04131	2.A.1.24,9.A.15.1	-	-	ATG22
HKD2_k127_10168451_0	1121405.dsmv_1640	0.0	1036.0	COG0204@1|root,COG0318@1|root,COG0204@2|Bacteria,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,42QS7@68525|delta/epsilon subdivisions,2X74U@28221|Deltaproteobacteria,2MN9G@213118|Desulfobacterales	28221|Deltaproteobacteria	IQ	AMP-binding enzyme	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,Acyltransferase,PP-binding
HKD2_k127_1028521_4	879212.DespoDRAFT_00562	5.816e-91	323.0	COG2202@1|root,COG2203@1|root,COG4191@1|root,COG4936@1|root,COG2202@2|Bacteria,COG2203@2|Bacteria,COG4191@2|Bacteria,COG4936@2|Bacteria,1R609@1224|Proteobacteria,42MTJ@68525|delta/epsilon subdivisions,2WJYM@28221|Deltaproteobacteria,2MMSJ@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GAF,GAF_2,HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Pkinase
HKD2_k127_1028521_2	243231.GSU2506	2.294e-161	527.0	COG2204@1|root,COG3829@1|root,COG2204@2|Bacteria,COG3829@2|Bacteria,1MU0N@1224|Proteobacteria,43BK2@68525|delta/epsilon subdivisions,2X6XX@28221|Deltaproteobacteria,43TUQ@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	Sigma-54-dependent sensor transcriptional response regulator, PAS domain-containing	-	-	-	ko:K07712	ko02020,map02020	M00497	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,PAS_4,PAS_9,Response_reg,Sigma54_activat
HKD2_k127_1028521_0	667014.Thein_0078	3.292e-200	640.0	COG0465@1|root,COG0465@2|Bacteria,2GHGM@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
HKD2_k127_1028521_5	1167006.UWK_03037	2.305e-42	163.0	2EQGF@1|root,33I2G@2|Bacteria,1NMWM@1224|Proteobacteria,42XGX@68525|delta/epsilon subdivisions,2WSWN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Class III cytochrome C family	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_CIII
HKD2_k127_1028521_3	316067.Geob_1593	8.706e-148	473.0	COG0437@1|root,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,42M97@68525|delta/epsilon subdivisions,2WJB4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	hmcB	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Fer4_11,Fer4_4,Fer4_7
HKD2_k127_1028521_1	1167006.UWK_03039	4.622e-186	589.0	COG5557@1|root,COG5557@2|Bacteria,1MWYI@1224|Proteobacteria,42P2Q@68525|delta/epsilon subdivisions,2WKC2@28221|Deltaproteobacteria,2MJCP@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM Polysulphide reductase, NrfD	hmcC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	NrfD
HKD2_k127_1028521_6	1167006.UWK_02210	2.832e-20	98.0	COG0642@1|root,COG2205@2|Bacteria	1167006.UWK_02210|-	T	PhoQ Sensor	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1030540_1	1121403.AUCV01000034_gene3874	2.391e-67	233.0	COG0682@1|root,COG0682@2|Bacteria,1MVE3@1224|Proteobacteria,42M2I@68525|delta/epsilon subdivisions,2WMSH@28221|Deltaproteobacteria,2MPU8@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	lgt	-	-	ko:K13292	-	-	-	-	ko00000,ko01000	-	-	-	LGT
HKD2_k127_1030540_3	1167006.UWK_02549	2.992e-30	129.0	COG0727@1|root,COG0727@2|Bacteria,1RFAY@1224|Proteobacteria,42S2M@68525|delta/epsilon subdivisions,2WNXP@28221|Deltaproteobacteria,2MJXF@213118|Desulfobacterales	28221|Deltaproteobacteria	S	PFAM Uncharacterised protein family (UPF0153)	-	-	-	-	-	-	-	-	-	-	-	-	CxxCxxCC
HKD2_k127_1030540_2	1125863.JAFN01000001_gene1251	1.084e-50	186.0	COG1047@1|root,COG1047@2|Bacteria,1RD35@1224|Proteobacteria,42MCS@68525|delta/epsilon subdivisions,2WRZW@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	Peptidyl-prolyl cis-trans	slyD	-	5.2.1.8	ko:K03775	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	FKBP_C
HKD2_k127_1030540_0	1167006.UWK_01435	7.558e-108	359.0	COG0288@1|root,COG0288@2|Bacteria,1NGFN@1224|Proteobacteria,42MSW@68525|delta/epsilon subdivisions,2WNY3@28221|Deltaproteobacteria,2MJ39@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Reversible hydration of carbon dioxide	-	-	4.2.1.1	ko:K01673	ko00910,map00910	-	R00132,R10092	RC02807	ko00000,ko00001,ko01000	-	-	-	Pro_CA
HKD2_k127_1030540_4	667014.Thein_0602	4.762e-18	87.0	COG0679@1|root,COG0679@2|Bacteria	2|Bacteria	S	auxin-activated signaling pathway	-	-	-	ko:K07088	-	-	-	-	ko00000	-	-	-	Mem_trans
HKD2_k127_1047305_0	335543.Sfum_2866	6.126e-162	525.0	COG2204@1|root,COG2204@2|Bacteria,1QYWF@1224|Proteobacteria,43CD6@68525|delta/epsilon subdivisions,2X7P0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	PFAM sigma-54 factor interaction domain-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	Sigma54_activat
HKD2_k127_1047305_1	903818.KI912268_gene1381	6.416e-58	213.0	COG3863@1|root,COG3863@2|Bacteria	2|Bacteria	T	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C92
HKD2_k127_1051360_2	448385.sce2453	2.151e-145	471.0	COG1166@1|root,COG1166@2|Bacteria,1MU80@1224|Proteobacteria,42M2B@68525|delta/epsilon subdivisions,2WJDZ@28221|Deltaproteobacteria,2YTWQ@29|Myxococcales	28221|Deltaproteobacteria	H	Catalyzes the biosynthesis of agmatine from arginine	speA	-	4.1.1.19	ko:K01585	ko00330,ko01100,map00330,map01100	M00133	R00566	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N
HKD2_k127_1051360_3	1167006.UWK_00574	9.164e-121	397.0	COG0010@1|root,COG0010@2|Bacteria,1MVFH@1224|Proteobacteria,42NBC@68525|delta/epsilon subdivisions,2WIMR@28221|Deltaproteobacteria,2MIAP@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Belongs to the arginase family	speB	-	3.5.3.1,3.5.3.11	ko:K01476,ko:K01480	ko00220,ko00330,ko01100,ko01110,ko01130,ko01230,ko05146,map00220,map00330,map01100,map01110,map01130,map01230,map05146	M00029,M00133,M00134	R00551,R01157	RC00024,RC00329	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
HKD2_k127_1051360_5	1121403.AUCV01000005_gene274	8.501e-90	302.0	COG1235@1|root,COG1235@2|Bacteria,1R5N4@1224|Proteobacteria,42NE6@68525|delta/epsilon subdivisions,2WJ92@28221|Deltaproteobacteria,2MJ1B@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B,Lactamase_B_2
HKD2_k127_1051360_7	1121403.AUCV01000005_gene273	1.62e-62	221.0	COG0756@1|root,COG0756@2|Bacteria,1RA7P@1224|Proteobacteria,42SJS@68525|delta/epsilon subdivisions,2WP7N@28221|Deltaproteobacteria,2MK9P@213118|Desulfobacterales	28221|Deltaproteobacteria	F	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA	dut	GO:0000287,GO:0003674,GO:0003824,GO:0004170,GO:0005488,GO:0006139,GO:0006220,GO:0006221,GO:0006226,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009141,GO:0009143,GO:0009147,GO:0009149,GO:0009157,GO:0009162,GO:0009165,GO:0009166,GO:0009176,GO:0009177,GO:0009200,GO:0009204,GO:0009211,GO:0009213,GO:0009219,GO:0009221,GO:0009223,GO:0009262,GO:0009263,GO:0009264,GO:0009265,GO:0009394,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046078,GO:0046080,GO:0046081,GO:0046385,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0047429,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0072529,GO:0090407,GO:1901135,GO:1901136,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576	3.6.1.23	ko:K01520	ko00240,ko00983,ko01100,map00240,map00983,map01100	M00053	R02100,R11896	RC00002	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	dUTPase
HKD2_k127_1051360_0	1121403.AUCV01000005_gene272	0.0	1068.0	COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,42MTZ@68525|delta/epsilon subdivisions,2WJCE@28221|Deltaproteobacteria,2MIS9@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004654,GO:0005488,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0019222,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901575	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
HKD2_k127_1051360_9	1167006.UWK_00012	4.106e-32	134.0	COG0184@1|root,COG0184@2|Bacteria,1MZ2W@1224|Proteobacteria,42TPZ@68525|delta/epsilon subdivisions,2WQ0P@28221|Deltaproteobacteria,2MKH5@213118|Desulfobacterales	28221|Deltaproteobacteria	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA	rpsO	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02956	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S15
HKD2_k127_1051360_6	1121403.AUCV01000005_gene270	3.139e-78	269.0	COG0130@1|root,COG0130@2|Bacteria,1MV0N@1224|Proteobacteria,42MU5@68525|delta/epsilon subdivisions,2WKWY@28221|Deltaproteobacteria,2MJFR@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs	truB	GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016556,GO:0016853,GO:0016866,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1990481	5.4.99.25	ko:K03177	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruB_C,TruB_C_2,TruB_N
HKD2_k127_1051360_4	1121403.AUCV01000005_gene269	1.257e-114	378.0	COG0618@1|root,COG0618@2|Bacteria,1RAUQ@1224|Proteobacteria,42RKG@68525|delta/epsilon subdivisions,2WN0X@28221|Deltaproteobacteria,2MJ6U@213118|Desulfobacterales	28221|Deltaproteobacteria	S	PFAM phosphoesterase RecJ domain protein	-	-	3.1.13.3,3.1.3.7	ko:K06881	ko00920,ko01100,ko01120,map00920,map01100,map01120	-	R00188,R00508	RC00078	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
HKD2_k127_1051360_8	1121403.AUCV01000005_gene268	6.295e-39	149.0	COG0858@1|root,COG0858@2|Bacteria,1MZPE@1224|Proteobacteria,42VQ6@68525|delta/epsilon subdivisions,2WRTU@28221|Deltaproteobacteria,2MKPU@213118|Desulfobacterales	28221|Deltaproteobacteria	J	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA	rbfA	-	-	ko:K02834	-	-	-	-	ko00000,ko03009	-	-	-	RBFA
HKD2_k127_1051360_1	1121403.AUCV01000005_gene267	5.284e-276	854.0	COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,42M5Q@68525|delta/epsilon subdivisions,2WIIX@28221|Deltaproteobacteria,2MIGT@213118|Desulfobacterales	28221|Deltaproteobacteria	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,IF-2,IF2_N
HKD2_k127_1063888_3	1121403.AUCV01000048_gene1066	1.996e-07	53.0	COG0715@1|root,COG0715@2|Bacteria,1PEB1@1224|Proteobacteria,42PTA@68525|delta/epsilon subdivisions,2WM25@28221|Deltaproteobacteria,2MIGF@213118|Desulfobacterales	28221|Deltaproteobacteria	P	NMT1/THI5 like	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
HKD2_k127_1063888_0	1121403.AUCV01000048_gene1065	7.489e-125	403.0	COG0600@1|root,COG0600@2|Bacteria,1NDW4@1224|Proteobacteria,42PPI@68525|delta/epsilon subdivisions,2WMA3@28221|Deltaproteobacteria,2MI72@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
HKD2_k127_1063888_2	1415756.JQMY01000001_gene3413	4.615e-15	84.0	COG1116@1|root,COG1116@2|Bacteria,1MU6C@1224|Proteobacteria,2TS5F@28211|Alphaproteobacteria,2PFH1@252301|Oceanicola	28211|Alphaproteobacteria	P	ATPases associated with a variety of cellular activities	-	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
HKD2_k127_1063888_1	1283300.ATXB01000001_gene380	3.036e-96	341.0	COG2982@1|root,COG2982@2|Bacteria,1MUME@1224|Proteobacteria,1RNPC@1236|Gammaproteobacteria,1XE60@135618|Methylococcales	135618|Methylococcales	M	Domain of Unknown Function (DUF748)	-	-	-	-	-	-	-	-	-	-	-	-	DUF748
HKD2_k127_1089211_9	1121403.AUCV01000001_gene907	3.943e-66	227.0	COG0735@1|root,COG0735@2|Bacteria,1N0HW@1224|Proteobacteria,42TU6@68525|delta/epsilon subdivisions,2WPZ1@28221|Deltaproteobacteria,2MKMK@213118|Desulfobacterales	28221|Deltaproteobacteria	K	Belongs to the Fur family	fur	-	-	ko:K03711,ko:K09825	-	-	-	-	ko00000,ko03000	-	-	-	FUR
HKD2_k127_1089211_5	589865.DaAHT2_0066	2.565e-116	383.0	COG0042@1|root,COG0042@2|Bacteria,1MV5V@1224|Proteobacteria,42M3I@68525|delta/epsilon subdivisions,2WIXZ@28221|Deltaproteobacteria,2MI4J@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines	-	-	-	-	-	-	-	-	-	-	-	-	Dus
HKD2_k127_1089211_1	1121403.AUCV01000001_gene909	4.22e-172	555.0	COG1180@1|root,COG1180@2|Bacteria,1QW1I@1224|Proteobacteria,43BRG@68525|delta/epsilon subdivisions,2X72A@28221|Deltaproteobacteria,2MHZ8@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Radical SAM superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
HKD2_k127_1089211_13	1121403.AUCV01000001_gene910	5.577e-55	196.0	28NQ4@1|root,2ZBPU@2|Bacteria,1RCN1@1224|Proteobacteria,42QPC@68525|delta/epsilon subdivisions,2WMVS@28221|Deltaproteobacteria,2MJR9@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1089211_0	1121403.AUCV01000001_gene911	2.662e-300	936.0	COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,42MEQ@68525|delta/epsilon subdivisions,2WIPF@28221|Deltaproteobacteria,2MMIM@213118|Desulfobacterales	28221|Deltaproteobacteria	G	TIGRFAM alpha-glucan	-	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	Phosphorylase
HKD2_k127_1089211_12	1121403.AUCV01000001_gene912	2.287e-56	203.0	COG2885@1|root,COG2885@2|Bacteria,1MZTV@1224|Proteobacteria,42R5H@68525|delta/epsilon subdivisions,2WNZS@28221|Deltaproteobacteria,2MJUT@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Belongs to the ompA family	pal	-	-	ko:K03640	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	OmpA
HKD2_k127_1089211_16	1167006.UWK_02124	1.641e-26	117.0	COG2825@1|root,COG2825@2|Bacteria,1MZVJ@1224|Proteobacteria,42VH3@68525|delta/epsilon subdivisions,2WP6K@28221|Deltaproteobacteria,2MK60@213118|Desulfobacterales	28221|Deltaproteobacteria	M	PFAM Outer membrane	-	-	-	ko:K06142	-	-	-	-	ko00000	-	-	-	OmpH
HKD2_k127_1089211_7	589865.DaAHT2_0716	3.718e-75	261.0	COG1456@1|root,COG1456@2|Bacteria,1R8JC@1224|Proteobacteria,42Q7Q@68525|delta/epsilon subdivisions,2WJXT@28221|Deltaproteobacteria,2MIQZ@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Domain of unknown function (DUF3786)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3786,FeS
HKD2_k127_1089211_4	1121403.AUCV01000001_gene914	2.272e-135	439.0	COG2870@1|root,COG2870@2|Bacteria,1MV3Z@1224|Proteobacteria,42MBC@68525|delta/epsilon subdivisions,2WIKU@28221|Deltaproteobacteria,2MJ7E@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Bifunctional protein	hldE	GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008713,GO:0008920,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016301,GO:0016310,GO:0016740,GO:0016757,GO:0016772,GO:0019200,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046401,GO:0046835,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	2.7.1.167,2.7.7.70	ko:K03272	ko00540,ko01100,map00540,map01100	M00064	R05644,R05646	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	iAF987.Gmet_0922	CTP_transf_like,PfkB
HKD2_k127_1089211_6	1121403.AUCV01000001_gene915	1.016e-99	332.0	COG1561@1|root,COG1561@2|Bacteria,1MWRA@1224|Proteobacteria,42RFR@68525|delta/epsilon subdivisions,2WJYK@28221|Deltaproteobacteria,2MIFF@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF1732)	yicC	-	-	-	-	-	-	-	-	-	-	-	DUF1732,YicC_N
HKD2_k127_1089211_15	1121403.AUCV01000001_gene916	1.788e-37	143.0	COG2052@1|root,COG2052@2|Bacteria,1N0KP@1224|Proteobacteria,42TSK@68525|delta/epsilon subdivisions,2WQHH@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Belongs to the UPF0296 family	-	-	-	ko:K09777	-	-	-	-	ko00000	-	-	-	DUF370
HKD2_k127_1089211_10	1167006.UWK_02129	4.72e-65	228.0	COG0194@1|root,COG0194@2|Bacteria,1MW92@1224|Proteobacteria,42R4H@68525|delta/epsilon subdivisions,2WPYD@28221|Deltaproteobacteria,2MPUI@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Essential for recycling GMP and indirectly, cGMP	gmk	-	2.7.4.8	ko:K00942	ko00230,ko01100,map00230,map01100	M00050	R00332,R02090	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_kin
HKD2_k127_1089211_8	1121403.AUCV01000001_gene918	3.942e-74	259.0	COG0566@1|root,COG0566@2|Bacteria,1MWCM@1224|Proteobacteria,42MZF@68525|delta/epsilon subdivisions,2WPA6@28221|Deltaproteobacteria,2MPUB@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family	-	-	2.1.1.185	ko:K03218	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SpoU_methylase,SpoU_sub_bind
HKD2_k127_1089211_3	1121403.AUCV01000001_gene919	2.245e-154	498.0	COG0539@1|root,COG0539@2|Bacteria,1N2EJ@1224|Proteobacteria,42NXS@68525|delta/epsilon subdivisions,2WJ0A@28221|Deltaproteobacteria,2MI43@213118|Desulfobacterales	28221|Deltaproteobacteria	J	PFAM RNA binding S1 domain protein	-	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
HKD2_k127_1089211_2	1167006.UWK_02139	2.767e-169	556.0	COG1032@1|root,COG1032@2|Bacteria,1NAY8@1224|Proteobacteria,42TR8@68525|delta/epsilon subdivisions,2WQC1@28221|Deltaproteobacteria,2MMMU@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
HKD2_k127_1089211_14	1167006.UWK_02140	6.638e-43	166.0	COG2834@1|root,COG2834@2|Bacteria,1PDTV@1224|Proteobacteria,42TAB@68525|delta/epsilon subdivisions,2WPXY@28221|Deltaproteobacteria,2MK70@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)	lolA	-	-	ko:K03634	-	-	-	-	ko00000	-	-	-	LolA
HKD2_k127_1089211_11	1167006.UWK_02141	3.158e-62	219.0	COG0796@1|root,COG0796@2|Bacteria,1NAI2@1224|Proteobacteria,42P58@68525|delta/epsilon subdivisions,2WKYK@28221|Deltaproteobacteria,2MIV5@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Provides the (R)-glutamate required for cell wall biosynthesis	murI	-	5.1.1.3	ko:K01776	ko00471,ko01100,map00471,map01100	-	R00260	RC00302	ko00000,ko00001,ko01000,ko01011	-	-	iAF987.Gmet_0547	Asp_Glu_race
HKD2_k127_111108_5	1121403.AUCV01000003_gene1771	2.85e-24	105.0	COG0787@1|root,COG0787@2|Bacteria,1MV0Q@1224|Proteobacteria,42MGU@68525|delta/epsilon subdivisions,2WIVG@28221|Deltaproteobacteria,2MHTA@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids	alr	-	5.1.1.1	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	-	R00401	RC00285	ko00000,ko00001,ko01000,ko01011	-	-	-	Ala_racemase_C,Ala_racemase_N
HKD2_k127_111108_2	1121403.AUCV01000003_gene1770	6.811e-48	175.0	2CEMF@1|root,33GFG@2|Bacteria,1NIQ6@1224|Proteobacteria,42X94@68525|delta/epsilon subdivisions	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_111108_4	1121403.AUCV01000003_gene1769	1.063e-31	125.0	COG1245@1|root,COG1245@2|Bacteria,1R2HD@1224|Proteobacteria,43DDV@68525|delta/epsilon subdivisions,2X8JP@28221|Deltaproteobacteria,2MPPM@213118|Desulfobacterales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
HKD2_k127_111108_1	1121403.AUCV01000001_gene988	3.495e-152	492.0	COG0303@1|root,COG0303@2|Bacteria,1MVD5@1224|Proteobacteria,42M5U@68525|delta/epsilon subdivisions,2WJ06@28221|Deltaproteobacteria,2MHZ7@213118|Desulfobacterales	28221|Deltaproteobacteria	H	TIGRFAM molybdenum cofactor synthesis domain	-	-	2.10.1.1	ko:K03750	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N
HKD2_k127_111108_0	1121403.AUCV01000001_gene987	4.586e-249	784.0	COG0303@1|root,COG1910@1|root,COG0303@2|Bacteria,COG1910@2|Bacteria,1MVD5@1224|Proteobacteria,42NQY@68525|delta/epsilon subdivisions,2WISG@28221|Deltaproteobacteria,2MIXC@213118|Desulfobacterales	28221|Deltaproteobacteria	HP	MoeA domain protein domain I and II	-	-	2.10.1.1	ko:K03750,ko:K07219	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N,PBP_like
HKD2_k127_111108_6	631362.Thi970DRAFT_01102	3.478e-12	74.0	2CFYY@1|root,3255I@2|Bacteria,1NVZK@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1125233_0	926569.ANT_14670	2.663e-185	597.0	COG2414@1|root,COG2414@2|Bacteria,2G5XP@200795|Chloroflexi	200795|Chloroflexi	C	PFAM aldehyde ferredoxin oxidoreductase	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
HKD2_k127_1125233_1	926550.CLDAP_35820	4.587e-26	112.0	COG3255@1|root,COG3255@2|Bacteria,2G95B@200795|Chloroflexi	200795|Chloroflexi	I	SCP-2 sterol transfer family	-	-	-	-	-	-	-	-	-	-	-	-	SCP2
HKD2_k127_1228986_0	316067.Geob_3357	2.316e-182	595.0	COG3420@1|root,COG3420@2|Bacteria,1QWWH@1224|Proteobacteria	1224|Proteobacteria	P	Beta-L-arabinofuranosidase, GH127	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,NosD,W_rich_C
HKD2_k127_1228986_5	323850.Shew_0327	1.219e-51	189.0	COG2370@1|root,COG2370@2|Bacteria,1N08F@1224|Proteobacteria,1SA2T@1236|Gammaproteobacteria,2QBDE@267890|Shewanellaceae	1236|Gammaproteobacteria	O	HupE / UreJ protein	-	-	-	ko:K03192	-	-	-	-	ko00000	-	-	-	HupE_UreJ
HKD2_k127_1228986_2	269799.Gmet_0568	1.359e-99	335.0	COG3221@1|root,COG3221@2|Bacteria,1NPBT@1224|Proteobacteria,42NX8@68525|delta/epsilon subdivisions,2X5DW@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	ABC transporter, phosphonate, periplasmic substrate-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	Phosphonate-bd
HKD2_k127_1228986_8	926566.Terro_3423	5.776e-09	64.0	COG0457@1|root,COG0457@2|Bacteria,3Y35N@57723|Acidobacteria,2JHIM@204432|Acidobacteriia	204432|Acidobacteriia	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_19,TPR_2,TPR_6,TPR_7,TPR_8
HKD2_k127_1228986_6	1173022.Cri9333_4514	1.034e-37	154.0	COG2215@1|root,COG2215@2|Bacteria,1G36H@1117|Cyanobacteria,1H9XA@1150|Oscillatoriales	1117|Cyanobacteria	S	Belongs to the NiCoT transporter (TC 2.A.52) family	-	-	-	ko:K08970	-	-	-	-	ko00000,ko02000	2.A.52.2	-	-	DsbD_2,NicO
HKD2_k127_1228986_1	1046724.KB889900_gene3202	6.852e-136	447.0	COG0015@1|root,COG0015@2|Bacteria,1MXNN@1224|Proteobacteria,1RS00@1236|Gammaproteobacteria,465DC@72275|Alteromonadaceae	1236|Gammaproteobacteria	F	Adenylosuccinate lyase C-terminus	-	-	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	-	ADSL_C,Lyase_1
HKD2_k127_1228986_3	717605.Theco_3548	1.33e-92	320.0	COG0015@1|root,COG0015@2|Bacteria,1TPMM@1239|Firmicutes,4HDVU@91061|Bacilli,26W4Z@186822|Paenibacillaceae	91061|Bacilli	F	Adenylosuccinate lyase C-terminus	-	-	4.3.2.2,5.5.1.2	ko:K01756,ko:K01857	ko00230,ko00250,ko00362,ko01100,ko01110,ko01120,ko01130,ko01220,map00230,map00250,map00362,map01100,map01110,map01120,map01130,map01220	M00048,M00049	R01083,R03307,R04559	RC00379,RC00444,RC00445,RC00902	ko00000,ko00001,ko00002,ko01000	-	-	-	ADSL_C,Lyase_1
HKD2_k127_1228986_4	1046724.KB889900_gene3201	7.219e-91	313.0	COG0334@1|root,COG0334@2|Bacteria,1MU10@1224|Proteobacteria	1224|Proteobacteria	C	Belongs to the Glu Leu Phe Val dehydrogenases family	-	-	1.4.1.3	ko:K00261	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
HKD2_k127_1234825_0	269799.Gmet_1664	1.889e-127	411.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJVV@28221|Deltaproteobacteria,43TFN@69541|Desulfuromonadales	28221|Deltaproteobacteria	V	AcrB/AcrD/AcrF family	-	-	-	ko:K03296,ko:K19594	-	M00768,M00769	-	-	ko00000,ko00002,ko01504,ko02000	2.A.6.2,2.A.6.2.25,2.A.6.2.34	-	-	ACR_tran
HKD2_k127_1234825_1	269799.Gmet_1664	2.182e-68	235.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJVV@28221|Deltaproteobacteria,43TFN@69541|Desulfuromonadales	28221|Deltaproteobacteria	V	AcrB/AcrD/AcrF family	-	-	-	ko:K03296,ko:K19594	-	M00768,M00769	-	-	ko00000,ko00002,ko01504,ko02000	2.A.6.2,2.A.6.2.25,2.A.6.2.34	-	-	ACR_tran
HKD2_k127_1234825_2	269799.Gmet_1665	1.99e-24	105.0	COG0845@1|root,COG0845@2|Bacteria,1MU78@1224|Proteobacteria,42P19@68525|delta/epsilon subdivisions,2WK00@28221|Deltaproteobacteria,43UEG@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Biotin-lipoyl like	-	-	-	ko:K19595	-	M00768,M00769	-	-	ko00000,ko00002,ko01504,ko02000	2.A.6.2.25,2.A.6.2.34,8.A.1	-	-	Biotin_lipoyl_2,HlyD_D23
HKD2_k127_1252926_3	1444711.CCJF01000005_gene366	1.31e-14	78.0	COG3119@1|root,COG3119@2|Bacteria,2JGI9@204428|Chlamydiae	204428|Chlamydiae	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
HKD2_k127_1252926_1	1454004.AW11_03211	1.295e-109	361.0	COG0560@1|root,COG0560@2|Bacteria,1MW38@1224|Proteobacteria,2VN83@28216|Betaproteobacteria	28216|Betaproteobacteria	E	haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD
HKD2_k127_1252926_2	78245.Xaut_2938	1.01e-20	92.0	COG0560@1|root,COG0560@2|Bacteria,1MW38@1224|Proteobacteria,2TVAB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD
HKD2_k127_1252926_0	880072.Desac_1235	4.65e-180	570.0	COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,42NKZ@68525|delta/epsilon subdivisions,2WIRB@28221|Deltaproteobacteria,2MQZS@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	PFAM Outer membrane efflux protein	-	-	-	ko:K18139	ko01501,ko02024,map01501,map02024	M00642,M00643,M00647,M00718,M00768,M00822	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	1.B.17,2.A.6.2	-	-	OEP
HKD2_k127_125330_10	667014.Thein_0849	9.863e-60	216.0	COG1566@1|root,COG1566@2|Bacteria,2GH9M@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	V	HlyD membrane-fusion protein of T1SS	-	-	-	ko:K03543	-	M00701	-	-	ko00000,ko00002,ko02000	8.A.1.1	-	-	Biotin_lipoyl_2,HlyD_D23
HKD2_k127_125330_3	717231.Flexsi_2219	1.605e-174	572.0	COG0477@1|root,COG2814@2|Bacteria,2GF7J@200930|Deferribacteres	200930|Deferribacteres	P	Major Facilitator Superfamily	-	-	-	ko:K03446	-	M00701	-	-	ko00000,ko00002,ko02000	2.A.1.3	-	-	MFS_1
HKD2_k127_125330_7	1121918.ARWE01000001_gene3103	8.537e-71	249.0	COG0589@1|root,COG0589@2|Bacteria,1QR0W@1224|Proteobacteria,42SGI@68525|delta/epsilon subdivisions,2WPQY@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD2_k127_125330_2	1121918.ARWE01000001_gene3102	1.019e-198	627.0	COG1914@1|root,COG1914@2|Bacteria,1MW6X@1224|Proteobacteria,42PNI@68525|delta/epsilon subdivisions,2WJNF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	PFAM natural resistance-associated macrophage protein	mntH	-	-	ko:K03322	-	-	-	-	ko00000,ko02000	2.A.55.2.6,2.A.55.3	-	-	Nramp,Usp
HKD2_k127_125330_14	1123393.KB891326_gene37	1.817e-13	79.0	COG3678@1|root,COG3678@2|Bacteria,1QC6V@1224|Proteobacteria,2WCBH@28216|Betaproteobacteria,1KTDB@119069|Hydrogenophilales	119069|Hydrogenophilales	NPTU	ATP-independent chaperone mediated protein folding	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_125330_13	595494.Tola_0689	1.359e-16	84.0	COG2501@1|root,COG2501@2|Bacteria,1N8C4@1224|Proteobacteria,1SCIR@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	S4 domain	ybcJ	-	-	ko:K14761	-	-	-	-	ko00000,ko03009	-	-	-	S4_2
HKD2_k127_125330_15	1046724.KB889881_gene1807	0.0005123	43.0	COG4096@1|root,COG4096@2|Bacteria,1QTS7@1224|Proteobacteria,1RN63@1236|Gammaproteobacteria,465IV@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	COG4096 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases	-	-	3.1.21.3	ko:K01153	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	EcoEI_R_C,HSDR_N,Helicase_C,ResIII
HKD2_k127_125330_12	177439.DP0670	2.545e-26	113.0	2CGNP@1|root,32S4A@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_125330_0	1167006.UWK_01240	0.0	1967.0	COG0046@1|root,COG0047@1|root,COG0046@2|Bacteria,COG0047@2|Bacteria,1MYN4@1224|Proteobacteria,42T70@68525|delta/epsilon subdivisions,2WUHA@28221|Deltaproteobacteria,2MPSU@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS_C,GATase_5
HKD2_k127_125330_5	177439.DP0716	2.709e-101	342.0	COG0635@1|root,COG0635@2|Bacteria,1MU76@1224|Proteobacteria,42NGU@68525|delta/epsilon subdivisions,2WIM5@28221|Deltaproteobacteria,2MI7T@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Involved in the biosynthesis of porphyrin-containing compound	-	-	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
HKD2_k127_125330_9	338966.Ppro_1867	2.425e-62	219.0	COG1335@1|root,COG1335@2|Bacteria,1RDHA@1224|Proteobacteria,42S3C@68525|delta/epsilon subdivisions,2X5QU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	Q	Isochorismatase family	-	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
HKD2_k127_125330_8	1121403.AUCV01000028_gene2432	4.949e-69	239.0	COG1881@1|root,COG1881@2|Bacteria,1N0Y4@1224|Proteobacteria,42WMA@68525|delta/epsilon subdivisions,2WRGN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Phosphatidylethanolamine-binding protein	-	-	-	ko:K06910	-	-	-	-	ko00000	-	-	-	PBP
HKD2_k127_125330_4	1121403.AUCV01000032_gene2866	1.365e-104	348.0	COG2003@1|root,COG2003@2|Bacteria,1MXZ5@1224|Proteobacteria,42PPW@68525|delta/epsilon subdivisions,2WM1S@28221|Deltaproteobacteria,2MIWE@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Belongs to the UPF0758 family	radC	-	-	ko:K03630	-	-	-	-	ko00000	-	-	-	RadC
HKD2_k127_125330_1	1121403.AUCV01000032_gene2865	9.69e-231	721.0	COG0064@1|root,COG0064@2|Bacteria,1MUKG@1224|Proteobacteria,42M31@68525|delta/epsilon subdivisions,2WJK4@28221|Deltaproteobacteria,2MIIZ@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatB	GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	GatB_N,GatB_Yqey
HKD2_k127_125330_6	1121403.AUCV01000032_gene2864	6.578e-80	269.0	COG2974@1|root,COG2974@2|Bacteria,1RCUH@1224|Proteobacteria,42QVW@68525|delta/epsilon subdivisions,2WN5B@28221|Deltaproteobacteria,2MJPM@213118|Desulfobacterales	28221|Deltaproteobacteria	L	May be involved in recombination	-	-	-	-	-	-	-	-	-	-	-	-	RdgC
HKD2_k127_125330_11	323261.Noc_2765	1.401e-42	177.0	COG0457@1|root,COG1672@1|root,COG0457@2|Bacteria,COG1672@2|Bacteria,1R3SH@1224|Proteobacteria,1S6CN@1236|Gammaproteobacteria,1WYE5@135613|Chromatiales	135613|Chromatiales	O	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_12,TPR_7
HKD2_k127_1274447_0	1121403.AUCV01000008_gene1619	0.0	1071.0	COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,42MGP@68525|delta/epsilon subdivisions,2WIZ2@28221|Deltaproteobacteria,2MI79@213118|Desulfobacterales	28221|Deltaproteobacteria	L	DNA polymerase III alpha subunit	dnaE	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
HKD2_k127_1274447_1	1120980.JQKH01000109_gene972	1.114e-132	430.0	COG0616@1|root,COG0616@2|Bacteria,1Q17C@1224|Proteobacteria,2W689@28216|Betaproteobacteria	28216|Betaproteobacteria	OU	signal peptide processing	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1274447_2	867903.ThesuDRAFT_02312	9.812e-53	197.0	COG0730@1|root,COG0730@2|Bacteria,1TRIE@1239|Firmicutes	1239|Firmicutes	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
HKD2_k127_1274447_3	1125863.JAFN01000001_gene2246	6.963e-08	55.0	COG0709@1|root,COG0709@2|Bacteria,1MWFG@1224|Proteobacteria,42MC3@68525|delta/epsilon subdivisions,2WK3M@28221|Deltaproteobacteria	28221|Deltaproteobacteria	F	Synthesizes selenophosphate from selenide and ATP	selD	-	2.7.9.3	ko:K01008	ko00450,ko01100,map00450,map01100	-	R03595	RC00002,RC02878	ko00000,ko00001,ko01000,ko03016	-	-	-	AIRS,AIRS_C
HKD2_k127_1285249_8	1307759.JOMJ01000003_gene439	6.643e-17	82.0	COG0835@1|root,COG0835@2|Bacteria,1RAH1@1224|Proteobacteria,42SH0@68525|delta/epsilon subdivisions,2WPFU@28221|Deltaproteobacteria,2MBI8@213115|Desulfovibrionales	28221|Deltaproteobacteria	NT	PFAM CheW domain protein	-	-	-	ko:K03408	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheW
HKD2_k127_1285249_2	269799.Gmet_2420	1.955e-90	306.0	COG1352@1|root,COG1352@2|Bacteria,1MU6W@1224|Proteobacteria,42MR2@68525|delta/epsilon subdivisions,2WKKH@28221|Deltaproteobacteria,43SBQ@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP	cheR34H	-	2.1.1.80	ko:K00575	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko01000,ko02035	-	-	-	CheR,CheR_N,Response_reg
HKD2_k127_1285249_5	443143.GM18_1420	1.806e-29	127.0	COG1871@1|root,COG1871@2|Bacteria,1RI55@1224|Proteobacteria,43AQB@68525|delta/epsilon subdivisions,2X646@28221|Deltaproteobacteria	28221|Deltaproteobacteria	NT	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis	-	-	3.5.1.44	ko:K03411	ko02030,map02030	-	-	-	ko00000,ko00001,ko01000,ko02035	-	-	-	CheD
HKD2_k127_1285249_0	243231.GSU1145	1.021e-161	515.0	COG2201@1|root,COG2201@2|Bacteria,1MWCN@1224|Proteobacteria,42M27@68525|delta/epsilon subdivisions,2WJ2S@28221|Deltaproteobacteria,43S6W@69541|Desulfuromonadales	28221|Deltaproteobacteria	NT	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR	cheB34H	-	3.1.1.61,3.5.1.44	ko:K03412	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest,Response_reg
HKD2_k127_1285249_3	589865.DaAHT2_2579	2.202e-61	220.0	COG0607@1|root,COG0607@2|Bacteria,1RM2N@1224|Proteobacteria	1224|Proteobacteria	P	SMART Rhodanese domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
HKD2_k127_1285249_7	1121406.JAEX01000003_gene1670	5.219e-19	91.0	28XV1@1|root,2ZJRD@2|Bacteria,1P0A1@1224|Proteobacteria,431X7@68525|delta/epsilon subdivisions,2WWA1@28221|Deltaproteobacteria,2MD9N@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	PFAM Late competence development protein ComFB	-	-	-	-	-	-	-	-	-	-	-	-	ComFB
HKD2_k127_1285249_4	903818.KI912268_gene1035	1.331e-30	125.0	COG0745@1|root,COG0745@2|Bacteria,3Y55U@57723|Acidobacteria	57723|Acidobacteria	T	cheY-homologous receiver domain	-	-	-	ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	Response_reg
HKD2_k127_1285249_1	903818.KI912268_gene1034	7.007e-92	310.0	COG1352@1|root,COG1352@2|Bacteria,3Y4FM@57723|Acidobacteria	57723|Acidobacteria	NT	Methyltransferase, chemotaxis proteins	-	-	2.1.1.80	ko:K00575	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko01000,ko02035	-	-	-	CheR
HKD2_k127_1285249_6	1121403.AUCV01000032_gene2871	4.403e-22	100.0	2EKNK@1|root,33ECA@2|Bacteria,1NHHJ@1224|Proteobacteria	1224|Proteobacteria	S	PFAM Type IV pilus assembly PilZ	-	-	-	-	-	-	-	-	-	-	-	-	PilZ
HKD2_k127_1285249_9	1121106.JQKB01000010_gene533	0.0001007	50.0	COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2TQR7@28211|Alphaproteobacteria,2JQPJ@204441|Rhodospirillales	204441|Rhodospirillales	NT	methyl-accepting chemotaxis protein	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	HAMP,MCPsignal,dCache_1
HKD2_k127_1286604_1	335543.Sfum_0196	3.768e-58	210.0	COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,42M5Q@68525|delta/epsilon subdivisions,2WIIX@28221|Deltaproteobacteria,2MQ8J@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	-	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	IF-2
HKD2_k127_1286604_2	1157490.EL26_05330	1.747e-20	100.0	COG4934@1|root,COG4934@2|Bacteria,1V06T@1239|Firmicutes,4HFKG@91061|Bacilli,2798Q@186823|Alicyclobacillaceae	91061|Bacilli	O	Pro-kumamolisin, activation domain	-	-	-	-	-	-	-	-	-	-	-	-	Pro-kuma_activ
HKD2_k127_1286604_0	1167006.UWK_00764	8.44e-125	408.0	COG2461@1|root,COG2461@2|Bacteria,1R5J5@1224|Proteobacteria,42QAZ@68525|delta/epsilon subdivisions,2WQTR@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM Hemerythrin HHE cation binding domain	-	-	-	ko:K09155	-	-	-	-	ko00000	-	-	-	DUF1858,DUF438,Hemerythrin,PAS_10
HKD2_k127_1297563_6	596152.DesU5LDRAFT_0913	2.539e-43	169.0	2AFUA@1|root,315WQ@2|Bacteria,1NHGB@1224|Proteobacteria,42TSA@68525|delta/epsilon subdivisions,2WQKD@28221|Deltaproteobacteria,2M9ZQ@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Putative transmembrane protein (Alph_Pro_TM)	-	-	-	-	-	-	-	-	-	-	-	-	Alph_Pro_TM
HKD2_k127_1297563_3	1322246.BN4_20022	1.654e-143	460.0	COG0730@1|root,COG0730@2|Bacteria,1MWX2@1224|Proteobacteria,42R15@68525|delta/epsilon subdivisions,2WJR6@28221|Deltaproteobacteria,2MGF0@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
HKD2_k127_1297563_1	1121456.ATVA01000001_gene3069	6.188e-175	558.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WJKZ@28221|Deltaproteobacteria,2MGPR@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	Bacterial regulatory protein, Fis family	-	-	-	ko:K07713	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD2_k127_1297563_4	1121396.KB892990_gene4480	5.609e-104	355.0	COG4191@1|root,COG4191@2|Bacteria,1P0U1@1224|Proteobacteria,42PTP@68525|delta/epsilon subdivisions,2WJ8U@28221|Deltaproteobacteria,2MIQ7@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
HKD2_k127_1297563_2	1499967.BAYZ01000050_gene2808	2.966e-160	511.0	COG1087@1|root,COG1087@2|Bacteria,2NNVI@2323|unclassified Bacteria	2|Bacteria	M	NAD(P)H-binding	galE	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
HKD2_k127_1297563_9	1167006.UWK_03423	8.768e-29	118.0	COG1342@1|root,COG1342@2|Bacteria,1N80T@1224|Proteobacteria,42WDZ@68525|delta/epsilon subdivisions,2WSGS@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Protein of unknown function  DUF134	-	-	-	-	-	-	-	-	-	-	-	-	DUF134
HKD2_k127_1297563_10	96561.Dole_0578	7.1e-20	94.0	COG1433@1|root,COG1433@2|Bacteria,1RDPR@1224|Proteobacteria,42SR6@68525|delta/epsilon subdivisions,2WPP8@28221|Deltaproteobacteria,2MJXD@213118|Desulfobacterales	28221|Deltaproteobacteria	S	PFAM Dinitrogenase iron-molybdenum cofactor	-	-	-	-	-	-	-	-	-	-	-	-	Nitro_FeMo-Co
HKD2_k127_1297563_8	589865.DaAHT2_1668	9.749e-31	123.0	COG1036@1|root,COG1036@2|Bacteria,1QW15@1224|Proteobacteria,43BR4@68525|delta/epsilon subdivisions,2X721@28221|Deltaproteobacteria,2MPIY@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
HKD2_k127_1297563_0	192952.MM_0420	1.261e-213	678.0	COG0674@1|root,arCOG01606@2157|Archaea,2XSUJ@28890|Euryarchaeota,2N91I@224756|Methanomicrobia	224756|Methanomicrobia	C	Pyruvate flavodoxin ferredoxin oxidoreductase domain protein	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR,POR_N
HKD2_k127_1297563_5	309799.DICTH_1570	7.402e-99	338.0	COG1013@1|root,COG1013@2|Bacteria	2|Bacteria	C	oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor	porB	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFO_beta_C,TPP_enzyme_C
HKD2_k127_1297563_7	1121403.AUCV01000019_gene3313	8.348e-31	124.0	COG2920@1|root,COG2920@2|Bacteria,1NPP9@1224|Proteobacteria,42XRZ@68525|delta/epsilon subdivisions,2WT1P@28221|Deltaproteobacteria,2MPQI@213118|Desulfobacterales	28221|Deltaproteobacteria	P	part of a sulfur-relay system	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1332049_0	667014.Thein_2065	7.036e-169	559.0	COG0574@1|root,COG3848@1|root,COG0574@2|Bacteria,COG3848@2|Bacteria,2GHHP@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	GT	Pyruvate phosphate dikinase, PEP/pyruvate binding domain	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PPDK_N
HKD2_k127_1332049_2	596151.DesfrDRAFT_3641	3.394e-39	149.0	COG2204@1|root,COG2204@2|Bacteria,1PZDN@1224|Proteobacteria,435WZ@68525|delta/epsilon subdivisions,2X0DD@28221|Deltaproteobacteria,2MBWS@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	PFAM response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
HKD2_k127_1332049_1	596152.DesU5LDRAFT_0906	1.66e-76	265.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,439Y6@68525|delta/epsilon subdivisions,2X1VE@28221|Deltaproteobacteria,2M9ND@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	histidine kinase HAMP region domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
HKD2_k127_1360609_0	1232410.KI421421_gene3246	0.0	1170.0	COG0243@1|root,COG0243@2|Bacteria,1NR6J@1224|Proteobacteria,43BMM@68525|delta/epsilon subdivisions,2WJJV@28221|Deltaproteobacteria,43TBB@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Molybdopterin oxidoreductase Fe4S4 domain	-	-	-	-	-	-	-	-	-	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
HKD2_k127_1360609_1	1232410.KI421421_gene3245	1.485e-52	188.0	COG0437@1|root,COG0437@2|Bacteria,1NF8S@1224|Proteobacteria,42WBD@68525|delta/epsilon subdivisions,2WRT3@28221|Deltaproteobacteria,43VH5@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_11
HKD2_k127_1394655_14	1121403.AUCV01000001_gene872	5.432e-49	179.0	COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,42M5A@68525|delta/epsilon subdivisions,2WK03@28221|Deltaproteobacteria,2MJNZ@213118|Desulfobacterales	28221|Deltaproteobacteria	E	ABC transporter	livF	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
HKD2_k127_1394655_6	1121403.AUCV01000001_gene871	6.07e-109	358.0	COG0411@1|root,COG0411@2|Bacteria,1MUTY@1224|Proteobacteria,42NMG@68525|delta/epsilon subdivisions,2WJIS@28221|Deltaproteobacteria,2MIA1@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Branched-chain amino acid ATP-binding cassette transporter	livG	-	-	ko:K01995,ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
HKD2_k127_1394655_15	794903.OPIT5_10435	4.575e-35	140.0	2EHW5@1|root,33BMQ@2|Bacteria,46WAC@74201|Verrucomicrobia,3K9R0@414999|Opitutae	414999|Opitutae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1394655_4	1167006.UWK_00090	1.06e-144	471.0	COG4177@1|root,COG4177@2|Bacteria,1MV66@1224|Proteobacteria,42TE0@68525|delta/epsilon subdivisions,2WPEP@28221|Deltaproteobacteria,2MKDG@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HKD2_k127_1394655_5	1121403.AUCV01000001_gene869	2.046e-136	439.0	COG0559@1|root,COG0559@2|Bacteria,1MU25@1224|Proteobacteria,42MKP@68525|delta/epsilon subdivisions,2WJU9@28221|Deltaproteobacteria,2MJJN@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	livH	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HKD2_k127_1394655_3	1167006.UWK_00092	2.464e-154	497.0	COG0683@1|root,COG0683@2|Bacteria,1MXR4@1224|Proteobacteria,42MXX@68525|delta/epsilon subdivisions,2WKJM@28221|Deltaproteobacteria,2MHQS@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Receptor family ligand binding region	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
HKD2_k127_1394655_12	1167006.UWK_00093	4.989e-63	219.0	COG4747@1|root,COG4747@2|Bacteria,1RDCG@1224|Proteobacteria,42RTD@68525|delta/epsilon subdivisions,2WNC2@28221|Deltaproteobacteria,2MK0D@213118|Desulfobacterales	28221|Deltaproteobacteria	S	PFAM amino acid-binding ACT domain protein	-	-	-	-	-	-	-	-	-	-	-	-	ACT
HKD2_k127_1394655_1	1121403.AUCV01000001_gene866	6.777e-236	734.0	COG1541@1|root,COG1541@2|Bacteria,1MV1W@1224|Proteobacteria,42NKD@68525|delta/epsilon subdivisions,2WIWV@28221|Deltaproteobacteria,2MIVW@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)	paaK-2	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	iAF987.Gmet_1825	AMP-binding,AMP-binding_C_2
HKD2_k127_1394655_10	1121403.AUCV01000001_gene865	2.301e-85	300.0	COG1014@1|root,COG1014@2|Bacteria,1RH9B@1224|Proteobacteria,42SK4@68525|delta/epsilon subdivisions,2WPI8@28221|Deltaproteobacteria,2MNKA@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Pyruvate ferredoxin/flavodoxin oxidoreductase	iorB-1	-	1.2.7.8	ko:K00180	-	-	-	-	br01601,ko00000,ko01000	-	-	-	POR
HKD2_k127_1394655_0	1121403.AUCV01000001_gene864	1.63e-300	932.0	COG4231@1|root,COG4231@2|Bacteria,1MUKS@1224|Proteobacteria,42N44@68525|delta/epsilon subdivisions,2WIX6@28221|Deltaproteobacteria,2MMVZ@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates	iorA-1	-	1.2.7.8	ko:K00179	-	-	-	-	br01601,ko00000,ko01000	-	-	-	Fer4,Fer4_7,POR_N,TPP_enzyme_C
HKD2_k127_1394655_13	439235.Dalk_4656	1.035e-51	205.0	COG5616@1|root,COG5616@2|Bacteria,1RBBE@1224|Proteobacteria,42QR8@68525|delta/epsilon subdivisions,2WN1X@28221|Deltaproteobacteria,2MHSI@213118|Desulfobacterales	28221|Deltaproteobacteria	S	PFAM Curli production assembly transport component CsgG	-	-	-	-	-	-	-	-	-	-	-	-	CsgG,VCBS
HKD2_k127_1394655_11	1121403.AUCV01000001_gene862	3.172e-74	255.0	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,42M2A@68525|delta/epsilon subdivisions,2WIJY@28221|Deltaproteobacteria,2MHT0@213118|Desulfobacterales	28221|Deltaproteobacteria	S	PFAM ABC transporter	-	-	-	ko:K06158	-	-	-	-	ko00000,ko03012	-	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
HKD2_k127_1394655_2	1121403.AUCV01000001_gene862	2.944e-200	631.0	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,42M2A@68525|delta/epsilon subdivisions,2WIJY@28221|Deltaproteobacteria,2MHT0@213118|Desulfobacterales	28221|Deltaproteobacteria	S	PFAM ABC transporter	-	-	-	ko:K06158	-	-	-	-	ko00000,ko03012	-	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
HKD2_k127_1394655_7	1121403.AUCV01000001_gene861	2.42e-99	335.0	COG0635@1|root,COG0635@2|Bacteria,1QWPM@1224|Proteobacteria,43BUG@68525|delta/epsilon subdivisions,2X75J@28221|Deltaproteobacteria,2MPKF@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Radical_SAM C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM,Radical_SAM_C
HKD2_k127_1394655_9	1121403.AUCV01000001_gene860	4.188e-94	314.0	COG0571@1|root,COG0571@2|Bacteria,1MUQ6@1224|Proteobacteria,42MIP@68525|delta/epsilon subdivisions,2WNDB@28221|Deltaproteobacteria,2MJYR@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism	rnc	GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004525,GO:0004540,GO:0005488,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0032296,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901363	3.1.26.3	ko:K03685	ko03008,ko05205,map03008,map05205	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019,ko03036	-	-	-	Ribonucleas_3_3,dsrm
HKD2_k127_1394655_16	1347086.CCBA010000012_gene2030	4.853e-06	51.0	2AWWM@1|root,31NU5@2|Bacteria,1TZQ8@1239|Firmicutes,4II4F@91061|Bacilli,1ZJ4J@1386|Bacillus	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1394655_8	1167006.UWK_01388	8.615e-98	329.0	COG3850@1|root,COG5002@1|root,COG3850@2|Bacteria,COG5002@2|Bacteria,1QTV1@1224|Proteobacteria,43BSP@68525|delta/epsilon subdivisions,2X5DD@28221|Deltaproteobacteria,2MJ1H@213118|Desulfobacterales	28221|Deltaproteobacteria	T	GHKL domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
HKD2_k127_1445231_8	1121403.AUCV01000020_gene3084	2.649e-44	179.0	COG1572@1|root,COG2165@1|root,COG1572@2|Bacteria,COG2165@2|Bacteria	2|Bacteria	NU	general secretion pathway protein	pilV	GO:0003674,GO:0005198,GO:0005575,GO:0005623,GO:0008150,GO:0009289,GO:0009405,GO:0009987,GO:0016043,GO:0030030,GO:0042995,GO:0044419,GO:0044464,GO:0051704,GO:0071840	-	ko:K02457,ko:K02458,ko:K10926,ko:K10930,ko:K10931	ko03070,ko05110,ko05111,map03070,map05110,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl,Shufflon_N,TcpA
HKD2_k127_1445231_6	1121403.AUCV01000020_gene3083	1.754e-72	246.0	COG2165@1|root,COG2165@2|Bacteria,1RDX2@1224|Proteobacteria,42SFB@68525|delta/epsilon subdivisions,2WP3B@28221|Deltaproteobacteria,2MJY4@213118|Desulfobacterales	28221|Deltaproteobacteria	U	general secretion pathway protein G	gspG	-	-	ko:K02456	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl,T2SSG
HKD2_k127_1445231_11	1232410.KI421418_gene2154	1.127e-06	59.0	COG2165@1|root,COG2165@2|Bacteria,1NZKC@1224|Proteobacteria,430RG@68525|delta/epsilon subdivisions,2WVSQ@28221|Deltaproteobacteria,43V4M@69541|Desulfuromonadales	28221|Deltaproteobacteria	NU	general secretion pathway protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1445231_9	1121403.AUCV01000003_gene1865	1.966e-42	172.0	COG1357@1|root,COG1357@2|Bacteria,1N7U9@1224|Proteobacteria,42X3G@68525|delta/epsilon subdivisions,2WTE4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Pentapeptide repeats (8 copies)	-	-	-	-	-	-	-	-	-	-	-	-	Pentapeptide
HKD2_k127_1445231_10	1121403.AUCV01000003_gene1866	4.317e-26	111.0	COG0268@1|root,COG0268@2|Bacteria,1NITA@1224|Proteobacteria,42V4U@68525|delta/epsilon subdivisions,2WR9I@28221|Deltaproteobacteria,2MKX3@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Binds directly to 16S ribosomal RNA	rpsT	-	-	ko:K02968	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S20p
HKD2_k127_1445231_0	589865.DaAHT2_0447	5.716e-199	632.0	COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,42MXN@68525|delta/epsilon subdivisions,2WJN0@28221|Deltaproteobacteria,2MI03@213118|Desulfobacterales	28221|Deltaproteobacteria	EH	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia	trpE	-	4.1.3.27	ko:K01657,ko:K13503	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
HKD2_k127_1445231_4	1121403.AUCV01000003_gene1868	1.087e-95	316.0	COG0512@1|root,COG0512@2|Bacteria,1MV5Y@1224|Proteobacteria,42QTS@68525|delta/epsilon subdivisions,2WN02@28221|Deltaproteobacteria,2MJQ6@213118|Desulfobacterales	28221|Deltaproteobacteria	EH	TIGRFAM glutamine amidotransferase of anthranilate synthase	trpG	-	2.6.1.85,4.1.3.27	ko:K01658,ko:K01664	ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986,R01716	RC00010,RC01418,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2496	GATase
HKD2_k127_1445231_2	1121403.AUCV01000003_gene1869	7.282e-152	488.0	COG0547@1|root,COG0547@2|Bacteria,1MUPV@1224|Proteobacteria,42NRG@68525|delta/epsilon subdivisions,2WJRU@28221|Deltaproteobacteria,2MIMY@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)	trpD	GO:0000162,GO:0003674,GO:0003824,GO:0004048,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.4.2.18,4.1.3.27	ko:K00766,ko:K13497	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R00985,R00986,R01073	RC00010,RC00440,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2495	GATase,Glycos_trans_3N,Glycos_transf_3
HKD2_k127_1445231_3	1121403.AUCV01000003_gene1870	8.784e-109	357.0	COG0134@1|root,COG0134@2|Bacteria,1MW5K@1224|Proteobacteria,42MAG@68525|delta/epsilon subdivisions,2WM94@28221|Deltaproteobacteria,2MJFU@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Belongs to the TrpC family	trpC	-	4.1.1.48,5.3.1.24	ko:K01609,ko:K13498	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03508,R03509	RC00944,RC00945	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2494	IGPS
HKD2_k127_1445231_5	1121403.AUCV01000003_gene1871	1.128e-82	280.0	COG0135@1|root,COG0135@2|Bacteria,1RA87@1224|Proteobacteria,42QQ3@68525|delta/epsilon subdivisions,2WNPH@28221|Deltaproteobacteria,2MJUG@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Belongs to the TrpF family	trpF	-	5.3.1.24	ko:K01817	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03509	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	PRAI
HKD2_k127_1445231_7	1121403.AUCV01000003_gene1872	6.295e-65	232.0	COG0797@1|root,COG3087@1|root,COG0797@2|Bacteria,COG3087@2|Bacteria,1MZ8S@1224|Proteobacteria,42PQF@68525|delta/epsilon subdivisions,2WMCA@28221|Deltaproteobacteria,2MHV7@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides	rlpA	-	-	ko:K03642	-	-	-	-	ko00000	-	-	-	DPBB_1,SPOR
HKD2_k127_1445231_1	1121403.AUCV01000003_gene1873	5.016e-152	496.0	COG3303@1|root,COG3303@2|Bacteria,1RFUW@1224|Proteobacteria,42S3M@68525|delta/epsilon subdivisions,2WNXA@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_c3_2
HKD2_k127_1449517_1	1167006.UWK_01738	9.131e-196	625.0	COG2199@1|root,COG2200@1|root,COG2199@2|Bacteria,COG2200@2|Bacteria,1MUQV@1224|Proteobacteria,43BUD@68525|delta/epsilon subdivisions,2WTMW@28221|Deltaproteobacteria,2MPRT@213118|Desulfobacterales	28221|Deltaproteobacteria	T	LapD/MoxY periplasmic domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,LapD_MoxY_N
HKD2_k127_1449517_3	1167006.UWK_01739	1.411e-80	274.0	COG3672@1|root,COG3672@2|Bacteria,1RDQS@1224|Proteobacteria,42QWJ@68525|delta/epsilon subdivisions,2WP0Q@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM transglutaminase family protein cysteine peptidase BTLCP	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C93
HKD2_k127_1449517_2	1167006.UWK_01740	3.545e-137	450.0	COG1538@1|root,COG1538@2|Bacteria,1R8XP@1224|Proteobacteria,42QM9@68525|delta/epsilon subdivisions,2WKY8@28221|Deltaproteobacteria,2MIGP@213118|Desulfobacterales	28221|Deltaproteobacteria	MU	PFAM Outer membrane efflux protein	-	-	-	ko:K12543	-	M00330	-	-	ko00000,ko00002,ko02000,ko02044	1.B.17,3.A.1.109.4	-	-	OEP
HKD2_k127_1449517_4	1121403.AUCV01000027_gene2509	1.552e-18	93.0	COG5512@1|root,COG5512@2|Bacteria	2|Bacteria	L	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DUF721
HKD2_k127_1449517_0	1121403.AUCV01000027_gene2508	0.0	1167.0	COG0031@1|root,COG0215@1|root,COG0031@2|Bacteria,COG0215@2|Bacteria,1MUBE@1224|Proteobacteria,42M6M@68525|delta/epsilon subdivisions,2WIQM@28221|Deltaproteobacteria,2MIN1@213118|Desulfobacterales	28221|Deltaproteobacteria	J	cysteinyl-tRNA synthetase	cysM	-	2.5.1.47,6.1.1.16	ko:K01738,ko:K01883,ko:K12339	ko00270,ko00920,ko00970,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map00970,map01100,map01110,map01120,map01130,map01200,map01230	M00021,M00359,M00360	R00897,R03132,R03601,R03650,R04859	RC00020,RC00055,RC00523,RC02814,RC02821,RC02876	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,PALP,tRNA-synt_1e
HKD2_k127_1455423_4	452637.Oter_3898	2.518e-07	54.0	COG1520@1|root,COG1520@2|Bacteria,46T0C@74201|Verrucomicrobia,3K9Y4@414999|Opitutae	414999|Opitutae	S	PFAM Pyrrolo-quinoline quinone	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_3
HKD2_k127_1455423_0	1128421.JAGA01000003_gene3650	2.163e-186	611.0	COG1198@1|root,COG1198@2|Bacteria,2NNQ3@2323|unclassified Bacteria	2|Bacteria	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006270,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0042623,GO:0043138,GO:0043140,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,ResIII
HKD2_k127_1455423_1	926569.ANT_07440	2.382e-96	323.0	COG1355@1|root,COG1355@2|Bacteria,2G6V0@200795|Chloroflexi	200795|Chloroflexi	S	Belongs to the MEMO1 family	-	-	-	ko:K06990	-	-	-	-	ko00000,ko04812	-	-	-	AMMECR1,Memo
HKD2_k127_1455423_3	926569.ANT_29490	3.604e-09	68.0	COG5662@1|root,COG5662@2|Bacteria,2G9S9@200795|Chloroflexi	200795|Chloroflexi	K	AntiSigma factor	-	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
HKD2_k127_1455423_2	926569.ANT_29500	2.09e-11	65.0	COG1595@1|root,COG1595@2|Bacteria,2G6MG@200795|Chloroflexi	200795|Chloroflexi	K	sigma-70 region 2 domain protein	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD2_k127_1491664_2	1121403.AUCV01000021_gene3602	1.736e-91	311.0	COG0144@1|root,COG0781@1|root,COG0144@2|Bacteria,COG0781@2|Bacteria,1MWPE@1224|Proteobacteria,42P2T@68525|delta/epsilon subdivisions,2WJ9B@28221|Deltaproteobacteria,2MI5Y@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA	rsmB	-	2.1.1.176	ko:K03500	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltr_RsmB-F,Methyltr_RsmF_N,NusB
HKD2_k127_1491664_3	1121403.AUCV01000021_gene3603	1.854e-44	168.0	2E1WK@1|root,3307R@2|Bacteria,1P535@1224|Proteobacteria,433RT@68525|delta/epsilon subdivisions,2WY3M@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1491664_0	1121403.AUCV01000021_gene3604	5.566e-140	456.0	COG0006@1|root,COG0006@2|Bacteria,1MUZS@1224|Proteobacteria,42M1K@68525|delta/epsilon subdivisions,2WJ8E@28221|Deltaproteobacteria,2MIXX@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Creatinase/Prolidase N-terminal domain	pepQ	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Creatinase_N_2,Peptidase_M24,Peptidase_M24_C
HKD2_k127_1491664_1	1167006.UWK_01508	1.572e-104	346.0	COG1875@1|root,COG1875@2|Bacteria,1MUX1@1224|Proteobacteria,42MK9@68525|delta/epsilon subdivisions,2WJ1C@28221|Deltaproteobacteria,2MIP5@213118|Desulfobacterales	28221|Deltaproteobacteria	T	PFAM PhoH-like protein	phoH1	-	-	ko:K07175	-	-	-	-	ko00000	-	-	-	PIN_4,PhoH
HKD2_k127_1501390_2	203119.Cthe_0056	1.227e-10	72.0	COG3210@1|root,COG4932@1|root,COG5492@1|root,COG3210@2|Bacteria,COG4932@2|Bacteria,COG5492@2|Bacteria,1UV19@1239|Firmicutes,25KDS@186801|Clostridia,3WP87@541000|Ruminococcaceae	186801|Clostridia	U	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1501390_0	1167006.UWK_00642	6.638e-115	382.0	COG1215@1|root,COG1215@2|Bacteria,1MW1E@1224|Proteobacteria,42ZKN@68525|delta/epsilon subdivisions,2WUTQ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3,Glycos_transf_2
HKD2_k127_1501390_1	1167006.UWK_00766	1.198e-15	78.0	COG1917@1|root,COG1917@2|Bacteria,1N2Q9@1224|Proteobacteria,42UBE@68525|delta/epsilon subdivisions,2WQDI@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	AraC_binding,Cupin_2
HKD2_k127_1504691_8	314345.SPV1_06499	7.589e-138	469.0	COG1752@1|root,COG1752@2|Bacteria,1Q82E@1224|Proteobacteria	1224|Proteobacteria	S	Esterase of the alpha-beta hydrolase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Patatin
HKD2_k127_1504691_9	1121403.AUCV01000001_gene816	1.478e-123	422.0	COG1466@1|root,COG1466@2|Bacteria,1RAEB@1224|Proteobacteria,42R0X@68525|delta/epsilon subdivisions,2WMQJ@28221|Deltaproteobacteria,2MJNX@213118|Desulfobacterales	28221|Deltaproteobacteria	L	DNA polymerase III, delta'	holA	-	2.7.7.7	ko:K02340	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta
HKD2_k127_1504691_12	1121403.AUCV01000001_gene815	1.506e-41	155.0	COG2127@1|root,COG2127@2|Bacteria,1MZU8@1224|Proteobacteria,42TN3@68525|delta/epsilon subdivisions,2WQ23@28221|Deltaproteobacteria,2MKNN@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation	clpS	-	-	ko:K06891	-	-	-	-	ko00000	-	-	-	ClpS
HKD2_k127_1504691_1	177439.DP0886	2.71e-309	964.0	COG0542@1|root,COG0542@2|Bacteria,1MV8B@1224|Proteobacteria,42M2T@68525|delta/epsilon subdivisions,2WJ2W@28221|Deltaproteobacteria,2MHMB@213118|Desulfobacterales	28221|Deltaproteobacteria	O	ATP-dependent Clp protease ATP-binding subunit ClpA	clpA	-	-	ko:K03694	-	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
HKD2_k127_1504691_3	1121403.AUCV01000001_gene813	4.921e-171	555.0	2C99Z@1|root,2Z9YV@2|Bacteria,1N0B7@1224|Proteobacteria,42Z3A@68525|delta/epsilon subdivisions,2WUES@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Protein of unknown function (DUF3373)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3373
HKD2_k127_1504691_11	177439.DP0599	2.072e-71	250.0	COG1496@1|root,COG1496@2|Bacteria,1MW2H@1224|Proteobacteria,42SE9@68525|delta/epsilon subdivisions,2WMQE@28221|Deltaproteobacteria,2MJIU@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Belongs to the multicopper oxidase YfiH RL5 family	-	-	-	ko:K05810	-	-	-	-	ko00000,ko01000	-	-	-	Cu-oxidase_4
HKD2_k127_1504691_10	1167006.UWK_01169	2.448e-95	317.0	COG3568@1|root,COG3568@2|Bacteria,1RBWV@1224|Proteobacteria,42QPA@68525|delta/epsilon subdivisions,2WMPU@28221|Deltaproteobacteria,2MJNT@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Endonuclease/Exonuclease/phosphatase family	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
HKD2_k127_1504691_7	1121403.AUCV01000001_gene810	4.51e-140	460.0	COG0617@1|root,COG0617@2|Bacteria,1MVCS@1224|Proteobacteria,42QKZ@68525|delta/epsilon subdivisions,2WJ74@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control	pcnB	-	2.7.7.19,2.7.7.72	ko:K00970,ko:K00974	ko03013,ko03018,map03013,map03018	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	PolyA_pol,PolyA_pol_RNAbd,PolyA_pol_arg_C
HKD2_k127_1504691_5	589865.DaAHT2_1537	1.058e-149	479.0	COG2070@1|root,COG2070@2|Bacteria,1MWPC@1224|Proteobacteria,43AEV@68525|delta/epsilon subdivisions,2X5YA@28221|Deltaproteobacteria,2MM2Q@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM 2-nitropropane dioxygenase NPD	-	-	1.13.12.16,1.3.1.9	ko:K00459,ko:K02371	ko00061,ko00910,ko01100,ko01212,map00061,map00910,map01100,map01212	M00083	R00025,R04429,R04724,R04955,R04958,R04961,R04966,R04969,R07765	RC00052,RC00076,RC02541,RC02759	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	NMO
HKD2_k127_1504691_4	1121403.AUCV01000001_gene808	4.18e-168	539.0	COG0124@1|root,COG0124@2|Bacteria,1MV2K@1224|Proteobacteria,42MG0@68525|delta/epsilon subdivisions,2WJE1@28221|Deltaproteobacteria,2MI2D@213118|Desulfobacterales	28221|Deltaproteobacteria	J	TIGRFAM histidyl-tRNA synthetase	hisS	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
HKD2_k127_1504691_0	1121403.AUCV01000001_gene807	5.78e-312	962.0	COG0173@1|root,COG0173@2|Bacteria,1MUXB@1224|Proteobacteria,42NC6@68525|delta/epsilon subdivisions,2WJEV@28221|Deltaproteobacteria,2MI7X@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
HKD2_k127_1504691_14	1121403.AUCV01000001_gene753	7.306e-15	78.0	COG2608@1|root,COG2608@2|Bacteria,1NGBD@1224|Proteobacteria	1224|Proteobacteria	P	heavy metal transport detoxification protein	merP	-	-	ko:K07213,ko:K08364	ko04978,map04978	-	-	-	ko00000,ko00001,ko02000	1.A.72.1	-	-	HMA
HKD2_k127_1504691_6	1121403.AUCV01000001_gene752	8.544e-145	475.0	COG0388@1|root,COG0615@1|root,COG0388@2|Bacteria,COG0615@2|Bacteria,1REW3@1224|Proteobacteria,42SGQ@68525|delta/epsilon subdivisions,2WPTP@28221|Deltaproteobacteria,2MJTC@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose	rfaE	-	-	-	-	-	-	-	-	-	-	-	CTP_transf_like
HKD2_k127_1504691_13	1121456.ATVA01000015_gene2428	3.297e-21	96.0	COG1413@1|root,COG1413@2|Bacteria,1R6G4@1224|Proteobacteria,42T2X@68525|delta/epsilon subdivisions,2WPNC@28221|Deltaproteobacteria,2MANX@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,HEAT_EZ
HKD2_k127_1535038_0	1121403.AUCV01000005_gene261	1.141e-234	740.0	COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,42N2G@68525|delta/epsilon subdivisions,2WIXB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	PFAM AMP-dependent synthetase and ligase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C,Acyltransferase,PP-binding
HKD2_k127_1536050_1	1167006.UWK_01951	2.875e-45	173.0	COG4191@1|root,COG4191@2|Bacteria,1R7KQ@1224|Proteobacteria,42PAP@68525|delta/epsilon subdivisions,2WITB@28221|Deltaproteobacteria,2MHP3@213118|Desulfobacterales	28221|Deltaproteobacteria	T	PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	2.7.13.3	ko:K02482	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,dCache_1
HKD2_k127_1536050_3	1167006.UWK_01950	4.11e-22	99.0	COG1433@1|root,COG1433@2|Bacteria,1N799@1224|Proteobacteria,42V7X@68525|delta/epsilon subdivisions,2WRG1@28221|Deltaproteobacteria,2MKXV@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Dinitrogenase iron-molybdenum cofactor	-	-	-	-	-	-	-	-	-	-	-	-	Nitro_FeMo-Co
HKD2_k127_1536050_0	1121459.AQXE01000005_gene1628	5.499e-136	446.0	COG3829@1|root,COG3829@2|Bacteria,1N1WB@1224|Proteobacteria,42P76@68525|delta/epsilon subdivisions,2WIU6@28221|Deltaproteobacteria,2M9BJ@213115|Desulfovibrionales	28221|Deltaproteobacteria	KT	PFAM sigma-54 factor interaction domain-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,PAS,PAS_4,PAS_9,Sigma54_activat
HKD2_k127_1536050_4	1304872.JAGC01000009_gene1444	0.0001086	51.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2M7UM@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	Two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	ko:K02481,ko:K07713	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD2_k127_1536050_2	706587.Desti_4443	2.327e-31	128.0	COG2204@1|root,COG2204@2|Bacteria,1QUMA@1224|Proteobacteria,43BKZ@68525|delta/epsilon subdivisions,2X6Z5@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
HKD2_k127_1536453_14	1157640.AQWO01000004_gene4805	1.808e-06	58.0	COG3321@1|root,COG3321@2|Bacteria,2IGI7@201174|Actinobacteria	201174|Actinobacteria	Q	polyketide synthase	-	-	-	-	-	-	-	-	-	-	-	-	ACPS,Acyl_transf_1,KAsynt_C_assoc,Ketoacyl-synt_C,PS-DH,ketoacyl-synt
HKD2_k127_1536453_9	1121403.AUCV01000027_gene2519	3.68e-41	160.0	COG1286@1|root,COG1286@2|Bacteria,1RJE1@1224|Proteobacteria,42SCW@68525|delta/epsilon subdivisions,2WPNX@28221|Deltaproteobacteria,2MKBI@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Colicin V production protein	-	-	-	ko:K03558	-	-	-	-	ko00000	-	-	-	Colicin_V
HKD2_k127_1536453_6	696747.NIES39_K00600	3.679e-59	213.0	COG1215@1|root,COG1215@2|Bacteria,1GDJY@1117|Cyanobacteria,1H8JX@1150|Oscillatoriales	1117|Cyanobacteria	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HKD2_k127_1536453_7	1173028.ANKO01000031_gene3928	1.643e-48	181.0	COG1216@1|root,COG3222@1|root,COG1216@2|Bacteria,COG3222@2|Bacteria,1G0X3@1117|Cyanobacteria,1HHXX@1150|Oscillatoriales	1117|Cyanobacteria	S	Glycosyl transferase family 2	-	-	-	ko:K09931	-	-	-	-	ko00000	-	-	-	DUF2064,Glycos_transf_2
HKD2_k127_1536453_5	1167006.UWK_01764	3.17e-70	246.0	COG2122@1|root,COG2122@2|Bacteria,1MV9Z@1224|Proteobacteria,42PMZ@68525|delta/epsilon subdivisions,2WMF7@28221|Deltaproteobacteria,2MJ13@213118|Desulfobacterales	28221|Deltaproteobacteria	S	PFAM ApbE family	-	-	-	ko:K09740	-	-	-	-	ko00000	-	-	-	-
HKD2_k127_1536453_13	1167006.UWK_01765	3.24e-30	128.0	2DSPU@1|root,33GZC@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	PilZ
HKD2_k127_1536453_4	1121403.AUCV01000027_gene2518	8.081e-102	339.0	COG1091@1|root,COG1091@2|Bacteria,1MUXM@1224|Proteobacteria,42MGE@68525|delta/epsilon subdivisions,2WKQ9@28221|Deltaproteobacteria,2MJZG@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose	rmlD	-	1.1.1.133	ko:K00067	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R02777	RC00182	ko00000,ko00001,ko00002,ko01000	-	-	-	RmlD_sub_bind
HKD2_k127_1536453_2	1121403.AUCV01000027_gene2517	3.515e-159	505.0	COG1209@1|root,COG1209@2|Bacteria,1MU0X@1224|Proteobacteria,42MTN@68525|delta/epsilon subdivisions,2WJAI@28221|Deltaproteobacteria,2MHRS@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis	rmlA	-	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
HKD2_k127_1536453_1	589865.DaAHT2_1732	2.013e-180	580.0	COG1109@1|root,COG1109@2|Bacteria,1MUA5@1224|Proteobacteria,42MET@68525|delta/epsilon subdivisions,2WITH@28221|Deltaproteobacteria,2MHR7@213118|Desulfobacterales	28221|Deltaproteobacteria	G	phosphoglucomutase phosphomannomutase alpha beta alpha domain I	algC	-	5.4.2.2,5.4.2.8	ko:K01840,ko:K15778	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
HKD2_k127_1536453_0	1167006.UWK_01769	2.336e-192	620.0	COG0662@1|root,COG0836@1|root,COG0662@2|Bacteria,COG0836@2|Bacteria,1MV39@1224|Proteobacteria,42MDP@68525|delta/epsilon subdivisions,2WJEN@28221|Deltaproteobacteria,2MIA7@213118|Desulfobacterales	28221|Deltaproteobacteria	M	TIGRFAM mannose-1-phosphate guanylyltransferase mannose-6-phosphate isomerase	-	-	2.7.7.13,5.3.1.8	ko:K00971,ko:K16011	ko00051,ko00520,ko01100,ko01110,ko01130,ko02025,map00051,map00520,map01100,map01110,map01130,map02025	M00114,M00361,M00362	R00885,R01819	RC00002,RC00376	ko00000,ko00001,ko00002,ko01000	-	-	-	MannoseP_isomer,NTP_transferase
HKD2_k127_1536453_12	1121403.AUCV01000027_gene2514	4.305e-35	138.0	2EC3H@1|root,3362D@2|Bacteria,1NDXP@1224|Proteobacteria,42WQJ@68525|delta/epsilon subdivisions,2WRNF@28221|Deltaproteobacteria,2MKWZ@213118|Desulfobacterales	28221|Deltaproteobacteria	S	PilZ domain	-	-	-	-	-	-	-	-	-	-	-	-	PilZ
HKD2_k127_1536453_3	443143.GM18_3089	4.312e-119	392.0	COG3005@1|root,COG3005@2|Bacteria,1RHMA@1224|Proteobacteria,42Z4M@68525|delta/epsilon subdivisions,2WU8J@28221|Deltaproteobacteria,43U75@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	cytochrome C	omcI	-	-	-	-	-	-	-	-	-	-	-	Paired_CXXCH_1
HKD2_k127_1536453_11	316067.Geob_2911	1.744e-35	155.0	2E1I6@1|root,32WW2@2|Bacteria,1NTI4@1224|Proteobacteria,42YDB@68525|delta/epsilon subdivisions,2WTNY@28221|Deltaproteobacteria,43TFS@69541|Desulfuromonadales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	MtrB_PioB
HKD2_k127_1536453_10	269799.Gmet_1746	2.63e-38	155.0	COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,42MU0@68525|delta/epsilon subdivisions,2WJW5@28221|Deltaproteobacteria,43UU9@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
HKD2_k127_1536453_8	589865.DaAHT2_0405	1.956e-44	171.0	COG3221@1|root,COG3221@2|Bacteria,1MXD8@1224|Proteobacteria,42UZB@68525|delta/epsilon subdivisions,2WQSS@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	ABC transporter, phosphonate, periplasmic substrate-binding protein	-	-	-	ko:K02044	ko02010,map02010	M00223	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.9	-	-	Phosphonate-bd
HKD2_k127_1549657_2	1121403.AUCV01000016_gene4401	4.061e-34	138.0	COG3907@1|root,COG3907@2|Bacteria,1QV68@1224|Proteobacteria,42V5Q@68525|delta/epsilon subdivisions,2WRMC@28221|Deltaproteobacteria,2MM29@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Acid phosphatase homologues	-	-	-	-	-	-	-	-	-	-	-	-	PAP2
HKD2_k127_1549657_0	1121403.AUCV01000010_gene1403	3.831e-166	537.0	COG1807@1|root,COG1807@2|Bacteria,1P6JE@1224|Proteobacteria,42QEZ@68525|delta/epsilon subdivisions,2WKYB@28221|Deltaproteobacteria,2MJ4D@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HKD2_k127_1549657_1	1121403.AUCV01000010_gene1402	4.677e-101	341.0	COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,1MU1Q@1224|Proteobacteria,42ND6@68525|delta/epsilon subdivisions,2WIJS@28221|Deltaproteobacteria,2MHY5@213118|Desulfobacterales	28221|Deltaproteobacteria	G	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	-	4.2.1.136,5.1.99.6	ko:K17758,ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	Carb_kinase,YjeF_N
HKD2_k127_155563_3	1121403.AUCV01000012_gene4035	1.551e-184	580.0	COG0649@1|root,COG0649@2|Bacteria,1MVIN@1224|Proteobacteria,42M9G@68525|delta/epsilon subdivisions,2WIS7@28221|Deltaproteobacteria,2MIC7@213118|Desulfobacterales	28221|Deltaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0016020,GO:0044424,GO:0044464,GO:0071944	1.6.5.3	ko:K00333,ko:K13378,ko:K13380	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa,Complex1_49kDa
HKD2_k127_155563_4	1121403.AUCV01000012_gene4036	2.33e-168	535.0	COG1005@1|root,COG1005@2|Bacteria,1MU2R@1224|Proteobacteria,42MMX@68525|delta/epsilon subdivisions,2WIX8@28221|Deltaproteobacteria,2MJHM@213118|Desulfobacterales	28221|Deltaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	nuoH	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
HKD2_k127_155563_5	1121403.AUCV01000012_gene4037	7.509e-65	224.0	COG1143@1|root,COG1143@2|Bacteria,1MV90@1224|Proteobacteria,42SZV@68525|delta/epsilon subdivisions,2WP8T@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoI	-	1.6.5.3	ko:K00338,ko:K05580	ko00190,ko01100,map00190,map01100	M00144,M00145	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer4,Fer4_4,Fer4_7
HKD2_k127_155563_6	1121403.AUCV01000012_gene4038	5.434e-56	205.0	COG0839@1|root,COG0839@2|Bacteria,1PJW9@1224|Proteobacteria,42V0F@68525|delta/epsilon subdivisions,2WS8G@28221|Deltaproteobacteria,2MNWY@213118|Desulfobacterales	28221|Deltaproteobacteria	C	NADH-ubiquinone/plastoquinone oxidoreductase chain 6	nuoJ	-	1.6.5.3	ko:K00339	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q3
HKD2_k127_155563_7	1167006.UWK_03566	6.598e-41	164.0	COG0713@1|root,COG0713@2|Bacteria,1RH0S@1224|Proteobacteria,42UWR@68525|delta/epsilon subdivisions,2WQRB@28221|Deltaproteobacteria,2MP1G@213118|Desulfobacterales	28221|Deltaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoK	-	1.6.5.3	ko:K00340,ko:K05576	ko00190,ko01100,map00190,map01100	M00144,M00145	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q2
HKD2_k127_155563_1	1121403.AUCV01000012_gene4040	7.292e-267	827.0	COG0651@1|root,COG0651@2|Bacteria,1QU5Z@1224|Proteobacteria,43BUI@68525|delta/epsilon subdivisions,2X75N@28221|Deltaproteobacteria,2MPKH@213118|Desulfobacterales	28221|Deltaproteobacteria	CP	Proton-conducting membrane transporter	-	-	-	ko:K05568	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Proton_antipo_M,Proton_antipo_N
HKD2_k127_155563_0	1121403.AUCV01000012_gene4042	1.633e-295	916.0	COG0651@1|root,COG0651@2|Bacteria,1MV6V@1224|Proteobacteria,42MSA@68525|delta/epsilon subdivisions,2WIS1@28221|Deltaproteobacteria,2MHQ9@213118|Desulfobacterales	28221|Deltaproteobacteria	CP	plastoquinone (complex I)	-	-	-	ko:K05568,ko:K12137	-	-	-	-	ko00000,ko01000,ko02000	2.A.63.1,2.A.63.2	-	-	Proton_antipo_M
HKD2_k127_155563_2	1121445.ATUZ01000013_gene1330	5.804e-216	681.0	COG1008@1|root,COG1008@2|Bacteria,1MV7V@1224|Proteobacteria,42NGD@68525|delta/epsilon subdivisions,2WJDC@28221|Deltaproteobacteria,2M89W@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain M	nuoM	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q5_N,Proton_antipo_M
HKD2_k127_1580331_0	269799.Gmet_0810	7.786e-216	672.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJVV@28221|Deltaproteobacteria,43TUU@69541|Desulfuromonadales	28221|Deltaproteobacteria	V	TIGRFAM transporter, hydrophobe amphiphile efflux-1 (HAE1) family	acrB	-	-	ko:K03296,ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
HKD2_k127_1580331_1	269799.Gmet_0809	2.582e-184	585.0	COG0845@1|root,COG0845@2|Bacteria,1MU78@1224|Proteobacteria,42NHV@68525|delta/epsilon subdivisions,2WJBA@28221|Deltaproteobacteria,43T2U@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	acrA	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	Biotin_lipoyl_2,HlyD,HlyD_3,HlyD_D23
HKD2_k127_1580331_2	269799.Gmet_0808	9.566e-68	233.0	COG1309@1|root,COG1309@2|Bacteria,1N0GT@1224|Proteobacteria,42RFI@68525|delta/epsilon subdivisions,2X5UB@28221|Deltaproteobacteria,43TM3@69541|Desulfuromonadales	28221|Deltaproteobacteria	K	Tetracycline repressor, C-terminal all-alpha domain	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_10,TetR_N
HKD2_k127_1586454_1	1167006.UWK_03036	1.301e-156	503.0	COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,42M4Z@68525|delta/epsilon subdivisions,2WJ0D@28221|Deltaproteobacteria,2MIPH@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	-	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
HKD2_k127_1586454_4	1121918.ARWE01000001_gene3002	8.145e-134	442.0	COG3005@1|root,COG3005@2|Bacteria,1R956@1224|Proteobacteria,42Q0X@68525|delta/epsilon subdivisions,2WMHI@28221|Deltaproteobacteria,43TAB@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	NapC/NirT cytochrome c family, N-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_NNT
HKD2_k127_1586454_3	1167006.UWK_03167	3.531e-143	462.0	COG1509@1|root,COG1509@2|Bacteria,1MUPJ@1224|Proteobacteria,42MNR@68525|delta/epsilon subdivisions,2WJ70@28221|Deltaproteobacteria,2MICE@213118|Desulfobacterales	28221|Deltaproteobacteria	C	TIGRFAM lysine 2,3-aminomutase YodO family protein	-	-	5.4.3.2	ko:K01843	ko00310,map00310	-	R00461	RC00303	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Fer4_14,LAM_C,Radical_SAM
HKD2_k127_1586454_0	1167006.UWK_03166	9.711e-271	846.0	COG0281@1|root,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,42MDI@68525|delta/epsilon subdivisions,2WIVY@28221|Deltaproteobacteria,2MHYG@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM malic	-	-	1.1.1.38,1.1.1.40	ko:K00027,ko:K00029	ko00620,ko00710,ko01100,ko01120,ko01200,ko02020,map00620,map00710,map01100,map01120,map01200,map02020	M00169,M00172	R00214,R00216	RC00105	ko00000,ko00001,ko00002,ko01000	-	-	-	Malic_M,malic
HKD2_k127_1586454_7	589865.DaAHT2_0436	2.192e-80	282.0	COG0577@1|root,COG0577@2|Bacteria,1R5BD@1224|Proteobacteria	1224|Proteobacteria	V	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HKD2_k127_1586454_10	1255043.TVNIR_2758	1.106e-57	208.0	COG1136@1|root,COG1136@2|Bacteria,1MVSQ@1224|Proteobacteria,1RMWK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	V	Part of the ABC transporter complex LolCDE involved in the translocation of	-	-	-	ko:K09810	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.125	-	-	ABC_tran
HKD2_k127_1586454_12	589865.DaAHT2_0925	1.847e-37	149.0	COG0526@1|root,COG0526@2|Bacteria,1Q3FH@1224|Proteobacteria,43A8D@68525|delta/epsilon subdivisions,2WRZR@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
HKD2_k127_1586454_11	589865.DaAHT2_0924	5.709e-42	165.0	COG4314@1|root,COG4314@2|Bacteria,1N43A@1224|Proteobacteria,42U7U@68525|delta/epsilon subdivisions,2WQYI@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM NosL family protein	-	-	-	-	-	-	-	-	-	-	-	-	NosL
HKD2_k127_1586454_13	589865.DaAHT2_0923	1.091e-21	102.0	2E5GP@1|root,3308B@2|Bacteria,1N858@1224|Proteobacteria,42VD7@68525|delta/epsilon subdivisions,2WSFR@28221|Deltaproteobacteria,2MPDE@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1586454_2	589865.DaAHT2_0922	4.47e-146	473.0	COG4591@1|root,COG4591@2|Bacteria,1QVSQ@1224|Proteobacteria,43BSZ@68525|delta/epsilon subdivisions,2WME9@28221|Deltaproteobacteria,2MMBK@213118|Desulfobacterales	28221|Deltaproteobacteria	M	FtsX-like permease family	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HKD2_k127_1586454_6	589865.DaAHT2_0921	7.006e-96	318.0	COG1136@1|root,COG1136@2|Bacteria,1PFRW@1224|Proteobacteria,42P38@68525|delta/epsilon subdivisions,2WMS9@28221|Deltaproteobacteria,2MNF2@213118|Desulfobacterales	28221|Deltaproteobacteria	V	PFAM ABC transporter related	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD2_k127_1586454_5	589865.DaAHT2_0920	4.969e-99	333.0	28K4S@1|root,2Z9TM@2|Bacteria,1N4AQ@1224|Proteobacteria,42PSN@68525|delta/epsilon subdivisions,2WNF4@28221|Deltaproteobacteria,2MM7R@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1586454_9	589865.DaAHT2_1518	6.691e-66	229.0	COG4567@1|root,COG4567@2|Bacteria,1RD7J@1224|Proteobacteria,42ZS1@68525|delta/epsilon subdivisions,2WV25@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	response regulator	-	-	-	ko:K15012	ko02020,map02020	M00523	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg
HKD2_k127_1586454_14	1297742.A176_06257	1.871e-19	89.0	COG4191@1|root,COG4191@2|Bacteria,1MWR3@1224|Proteobacteria,42WNA@68525|delta/epsilon subdivisions,2WRKM@28221|Deltaproteobacteria,2YUJ7@29|Myxococcales	28221|Deltaproteobacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K15011	ko02020,map02020	M00523	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA
HKD2_k127_1590340_1	237609.PSAKL28_25280	2.018e-117	382.0	COG4623@1|root,COG4623@2|Bacteria,1MWDS@1224|Proteobacteria,1RM8W@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella	mltF2	GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944	-	ko:K18691	-	-	-	-	ko00000,ko01000,ko01011	-	-	-	SBP_bac_3,SLT
HKD2_k127_1590340_2	1304885.AUEY01000011_gene1728	1.854e-91	325.0	COG3437@1|root,COG3437@2|Bacteria,1MUB8@1224|Proteobacteria,42QYY@68525|delta/epsilon subdivisions,2WNXG@28221|Deltaproteobacteria,2MNAV@213118|Desulfobacterales	28221|Deltaproteobacteria	KT	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	HD
HKD2_k127_1590340_3	1234595.C725_2212	1.368e-19	98.0	COG2885@1|root,COG3637@1|root,COG2885@2|Bacteria,COG3637@2|Bacteria,1N6EM@1224|Proteobacteria,2U17R@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Belongs to the ompA family	-	-	-	-	-	-	-	-	-	-	-	-	Autotransporter,OMP_b-brl,OmpA
HKD2_k127_1590340_0	1232410.KI421426_gene1472	0.0	1088.0	COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,42N22@68525|delta/epsilon subdivisions,2WIMH@28221|Deltaproteobacteria,43U0M@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties	glgP	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	Phosphorylase
HKD2_k127_1595034_3	589865.DaAHT2_2481	5.645e-198	632.0	COG0646@1|root,COG0685@1|root,COG0646@2|Bacteria,COG0685@2|Bacteria,1NPFY@1224|Proteobacteria,43BU7@68525|delta/epsilon subdivisions,2X757@28221|Deltaproteobacteria,2MJ6M@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Homocysteine S-methyltransferase	-	-	1.5.1.20,2.1.1.10,2.1.1.13	ko:K00297,ko:K00547,ko:K00548	ko00270,ko00450,ko00670,ko00720,ko01100,ko01110,ko01120,ko01200,ko01230,ko01523,map00270,map00450,map00670,map00720,map01100,map01110,map01120,map01200,map01230,map01523	M00017,M00377	R00650,R00946,R01224,R07168,R09365	RC00003,RC00035,RC00081,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	S-methyl_trans
HKD2_k127_1595034_1	589865.DaAHT2_2480	2.5e-217	678.0	COG0192@1|root,COG0192@2|Bacteria,1MUFQ@1224|Proteobacteria,42MFM@68525|delta/epsilon subdivisions,2WIQ3@28221|Deltaproteobacteria,2MHVQ@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme	metK	GO:0003674,GO:0003824,GO:0004478,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016740,GO:0016765,GO:0044424,GO:0044444,GO:0044464	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
HKD2_k127_1595034_0	1121403.AUCV01000012_gene4116	7.951e-244	757.0	COG0499@1|root,COG0499@2|Bacteria,1MUQ2@1224|Proteobacteria,42M83@68525|delta/epsilon subdivisions,2WIZE@28221|Deltaproteobacteria,2MI5G@213118|Desulfobacterales	28221|Deltaproteobacteria	H	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine	ahcY	GO:0000096,GO:0003674,GO:0003824,GO:0004013,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009069,GO:0009116,GO:0009119,GO:0009987,GO:0016787,GO:0016801,GO:0016802,GO:0017144,GO:0019752,GO:0033353,GO:0034641,GO:0042278,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901605,GO:1901657	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
HKD2_k127_1595034_6	1121403.AUCV01000012_gene4117	1.835e-77	262.0	COG3584@1|root,COG3584@2|Bacteria	2|Bacteria	T	3D domain protein	DR0488	-	-	ko:K21471	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	3D,NLPC_P60,Peptidase_M23
HKD2_k127_1595034_4	1121403.AUCV01000012_gene4118	3.792e-179	584.0	COG1206@1|root,COG1206@2|Bacteria,1MWNQ@1224|Proteobacteria,42MTS@68525|delta/epsilon subdivisions,2WJ50@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs	trmFO	GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363	2.1.1.74	ko:K04094	-	-	-	-	ko00000,ko01000,ko03016,ko03036	-	-	-	GIDA
HKD2_k127_1595034_5	1167006.UWK_01809	9.145e-158	525.0	COG0457@1|root,COG3307@1|root,COG0457@2|Bacteria,COG3307@2|Bacteria,1N225@1224|Proteobacteria,42QDQ@68525|delta/epsilon subdivisions,2WM6B@28221|Deltaproteobacteria,2MIM4@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Lipid A core-O-antigen ligase-like enyme	-	-	-	ko:K18814	-	-	-	-	ko00000,ko02000	9.B.67.1	-	-	TPR_14,TPR_16,TPR_8,Wzy_C
HKD2_k127_1595034_8	338963.Pcar_1540	1.559e-47	193.0	COG4464@1|root,COG4464@2|Bacteria,1R5E2@1224|Proteobacteria,42UBJ@68525|delta/epsilon subdivisions,2WQ5M@28221|Deltaproteobacteria,43UH1@69541|Desulfuromonadales	28221|Deltaproteobacteria	GM	PFAM PHP domain protein	-	-	3.1.3.48	ko:K01104	-	-	-	-	ko00000,ko01000	-	-	-	-
HKD2_k127_1595034_2	1167006.UWK_01814	3.368e-201	650.0	COG0489@1|root,COG3206@1|root,COG0489@2|Bacteria,COG3206@2|Bacteria,1MVI9@1224|Proteobacteria,42NB4@68525|delta/epsilon subdivisions,2WK9E@28221|Deltaproteobacteria,2MHUB@213118|Desulfobacterales	28221|Deltaproteobacteria	D	G-rich domain on putative tyrosine kinase	wzc2	-	-	ko:K16554	ko05111,map05111	-	-	-	ko00000,ko00001,ko02000	8.A.3.1	-	-	AAA_31,CbiA,GNVR,ParA,Wzz
HKD2_k127_1595034_7	1167006.UWK_01815	5.323e-75	257.0	COG1596@1|root,COG1596@2|Bacteria,1N7GP@1224|Proteobacteria,42MNP@68525|delta/epsilon subdivisions,2WMJZ@28221|Deltaproteobacteria,2MJAM@213118|Desulfobacterales	28221|Deltaproteobacteria	M	export protein	wza2	-	-	ko:K01991	ko02026,map02026	-	-	-	ko00000,ko00001,ko02000	1.B.18	-	-	Poly_export,SLBB
HKD2_k127_1602305_10	1121403.AUCV01000034_gene3850	1.452e-63	228.0	COG1381@1|root,COG1381@2|Bacteria,1RIBW@1224|Proteobacteria,42PUE@68525|delta/epsilon subdivisions,2WK4W@28221|Deltaproteobacteria,2MJFE@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Involved in DNA repair and RecF pathway recombination	recO	-	-	ko:K03584	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecO_C,RecO_N
HKD2_k127_1602305_8	589865.DaAHT2_0465	1.126e-74	261.0	COG0340@1|root,COG0340@2|Bacteria	2|Bacteria	H	biotin-[acetyl-CoA-carboxylase] ligase activity	birA	-	6.3.4.15	ko:K03524	ko00780,ko01100,map00780,map01100	-	R01074,R05145	RC00043,RC00070,RC00096,RC02896	ko00000,ko00001,ko01000,ko03000	-	-	iLJ478.TM0224	BPL_C,BPL_LplA_LipB
HKD2_k127_1602305_4	1167006.UWK_00437	1.77e-99	328.0	COG0511@1|root,COG0511@2|Bacteria,1MXJ4@1224|Proteobacteria,42QIZ@68525|delta/epsilon subdivisions,2WKQ2@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	ligase activity, forming carbon-carbon bonds	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1602305_6	1121403.AUCV01000034_gene3864	1.024e-85	290.0	COG0500@1|root,COG2226@2|Bacteria,1MV4M@1224|Proteobacteria,42NNI@68525|delta/epsilon subdivisions,2WKND@28221|Deltaproteobacteria,2MIX4@213118|Desulfobacterales	28221|Deltaproteobacteria	Q	Catalyzes the conversion of S-adenosyl-L-methionine (SAM) to carboxy-S-adenosyl-L-methionine (Cx-SAM)	cmoA	-	-	ko:K15256	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltransf_25,Methyltransf_31
HKD2_k127_1602305_3	1121403.AUCV01000034_gene3865	2.141e-132	428.0	COG0500@1|root,COG0500@2|Bacteria,1MVSK@1224|Proteobacteria,42N9H@68525|delta/epsilon subdivisions,2WJMK@28221|Deltaproteobacteria,2MIEP@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Catalyzes carboxymethyl transfer from carboxy-S- adenosyl-L-methionine (Cx-SAM) to 5-hydroxyuridine (ho5U) to form 5-carboxymethoxyuridine (cmo5U) at position 34 in tRNAs	cmoB	-	-	ko:K15257	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltransf_9
HKD2_k127_1602305_5	1121403.AUCV01000034_gene3866	4.543e-95	314.0	COG0467@1|root,COG0467@2|Bacteria,1RFBT@1224|Proteobacteria,42QWP@68525|delta/epsilon subdivisions,2WMB2@28221|Deltaproteobacteria,2MISH@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1602305_9	1121403.AUCV01000034_gene3867	2.781e-69	245.0	COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,42P5W@68525|delta/epsilon subdivisions,2WMA6@28221|Deltaproteobacteria,2MHP7@213118|Desulfobacterales	28221|Deltaproteobacteria	M	PFAM peptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
HKD2_k127_1602305_12	1121403.AUCV01000034_gene3868	1.213e-31	128.0	COG1664@1|root,COG1664@2|Bacteria,1MZG6@1224|Proteobacteria	1224|Proteobacteria	M	Integral membrane protein CcmA involved in cell shape determination	WS1240	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
HKD2_k127_1602305_2	1121403.AUCV01000034_gene3869	4.074e-157	510.0	COG0486@1|root,COG0486@2|Bacteria,1MUCQ@1224|Proteobacteria,42M6T@68525|delta/epsilon subdivisions,2WIWY@28221|Deltaproteobacteria,2MHR1@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34	mnmE	-	-	ko:K03650	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko01000,ko03016	-	-	-	MMR_HSR1,MnmE_helical,TrmE_N
HKD2_k127_1602305_7	1121403.AUCV01000034_gene3870	3.12e-77	270.0	COG1847@1|root,COG1847@2|Bacteria,1RB1P@1224|Proteobacteria,42QPK@68525|delta/epsilon subdivisions,2WN58@28221|Deltaproteobacteria,2MJJC@213118|Desulfobacterales	28221|Deltaproteobacteria	S	PFAM single-stranded nucleic acid binding R3H	-	-	-	ko:K06346	-	-	-	-	ko00000	-	-	-	Jag_N,KH_4,R3H
HKD2_k127_1602305_1	1121403.AUCV01000034_gene3871	3.781e-205	651.0	COG0706@1|root,COG0706@2|Bacteria,1MV5M@1224|Proteobacteria,42MS8@68525|delta/epsilon subdivisions,2WJB6@28221|Deltaproteobacteria,2MJ96@213118|Desulfobacterales	28221|Deltaproteobacteria	U	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins	yidC	-	-	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03029	2.A.9	-	-	60KD_IMP,YidC_periplas
HKD2_k127_1602305_14	266117.Rxyl_3214	1.584e-25	109.0	COG0759@1|root,COG0759@2|Bacteria,2GQZG@201174|Actinobacteria,4CQSS@84995|Rubrobacteria	84995|Rubrobacteria	S	Could be involved in insertion of integral membrane proteins into the membrane	-	-	-	ko:K08998	-	-	-	-	ko00000	-	-	-	Haemolytic
HKD2_k127_1602305_13	177439.DP0854	9.699e-27	113.0	COG0594@1|root,COG0594@2|Bacteria	2|Bacteria	J	ribonuclease P activity	rnpA	GO:0000966,GO:0001682,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005655,GO:0005730,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0030677,GO:0030681,GO:0031123,GO:0031404,GO:0031974,GO:0031981,GO:0032991,GO:0033204,GO:0034414,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0040007,GO:0042301,GO:0042779,GO:0042780,GO:0042781,GO:0043167,GO:0043168,GO:0043170,GO:0043199,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043628,GO:0044237,GO:0044238,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044452,GO:0044464,GO:0046483,GO:0070013,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0099116,GO:0140098,GO:0140101,GO:1901360,GO:1901363,GO:1901681,GO:1902494,GO:1902555,GO:1905267,GO:1905348,GO:1990904	3.1.26.5	ko:K03536,ko:K08998	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Ribonuclease_P
HKD2_k127_1602305_15	335543.Sfum_2594	5.47e-15	75.0	COG0230@1|root,COG0230@2|Bacteria,1NGGS@1224|Proteobacteria,42WSU@68525|delta/epsilon subdivisions,2WSI8@28221|Deltaproteobacteria,2MSEK@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	Belongs to the bacterial ribosomal protein bL34 family	rpmH	-	-	ko:K02914	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L34
HKD2_k127_1602305_0	1121403.AUCV01000034_gene3873	2.537e-287	897.0	COG0445@1|root,COG0445@2|Bacteria,1MU6F@1224|Proteobacteria,42KZC@68525|delta/epsilon subdivisions,2WJ31@28221|Deltaproteobacteria,2MJBM@213118|Desulfobacterales	28221|Deltaproteobacteria	D	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34	gidA	GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363	-	ko:K03495	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko03016,ko03036	-	-	-	GIDA,GIDA_assoc
HKD2_k127_1602305_11	589865.DaAHT2_1973	4.817e-38	145.0	COG0682@1|root,COG0682@2|Bacteria,1MVE3@1224|Proteobacteria,42M2I@68525|delta/epsilon subdivisions,2WMSH@28221|Deltaproteobacteria,2MPU8@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	lgt	-	-	ko:K13292	-	-	-	-	ko00000,ko01000	-	-	-	LGT
HKD2_k127_1606267_6	1121403.AUCV01000020_gene3084	1.024e-81	286.0	COG1572@1|root,COG2165@1|root,COG1572@2|Bacteria,COG2165@2|Bacteria	2|Bacteria	NU	general secretion pathway protein	pilV	GO:0003674,GO:0005198,GO:0005575,GO:0005623,GO:0008150,GO:0009289,GO:0009405,GO:0009987,GO:0016043,GO:0030030,GO:0042995,GO:0044419,GO:0044464,GO:0051704,GO:0071840	-	ko:K02457,ko:K02458,ko:K10926,ko:K10930,ko:K10931	ko03070,ko05110,ko05111,map03070,map05110,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl,Shufflon_N,TcpA
HKD2_k127_1606267_4	1123393.KB891332_gene2681	4.468e-102	354.0	COG0457@1|root,COG0457@2|Bacteria,1MXK4@1224|Proteobacteria	1224|Proteobacteria	S	Oxygen tolerance	batD	-	-	-	-	-	-	-	-	-	-	-	BatD
HKD2_k127_1606267_2	765911.Thivi_0874	1.301e-123	420.0	COG0457@1|root,COG2304@1|root,COG0457@2|Bacteria,COG2304@2|Bacteria,1MW51@1224|Proteobacteria,1RMD3@1236|Gammaproteobacteria,1WWHI@135613|Chromatiales	135613|Chromatiales	S	von Willebrand factor, type A	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	TPR_1,TPR_16,VWA_2
HKD2_k127_1606267_5	1056820.KB900632_gene2175	1.376e-97	331.0	COG2304@1|root,COG2304@2|Bacteria,1MXQ7@1224|Proteobacteria,1RMDX@1236|Gammaproteobacteria,2PMK4@256005|Alteromonadales genera incertae sedis	1236|Gammaproteobacteria	S	von Willebrand factor (vWF) type A domain	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VWA,VWA_2
HKD2_k127_1606267_8	768671.ThimaDRAFT_4342	1.361e-28	123.0	COG2304@1|root,COG2304@2|Bacteria,1QVQA@1224|Proteobacteria,1S9W8@1236|Gammaproteobacteria,1WYQH@135613|Chromatiales	135613|Chromatiales	S	Domain of unknown function (DUF4381)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4381
HKD2_k127_1606267_7	686340.Metal_0117	1.273e-65	235.0	COG1721@1|root,COG1721@2|Bacteria,1Q7RR@1224|Proteobacteria,1RNNP@1236|Gammaproteobacteria,1XEJ0@135618|Methylococcales	135618|Methylococcales	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
HKD2_k127_1606267_1	1123393.KB891332_gene2687	2.517e-133	436.0	COG0714@1|root,COG0714@2|Bacteria,1MUFN@1224|Proteobacteria,2VKJJ@28216|Betaproteobacteria,1KT36@119069|Hydrogenophilales	119069|Hydrogenophilales	S	ATPase family associated with various cellular activities (AAA)	-	-	-	-	-	-	-	-	-	-	-	-	AAA_3
HKD2_k127_1606267_10	1121405.dsmv_0169	6.408e-21	94.0	COG2835@1|root,COG2835@2|Bacteria,1Q1BG@1224|Proteobacteria,42WTN@68525|delta/epsilon subdivisions,2WSI9@28221|Deltaproteobacteria,2MM3G@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Belongs to the UPF0434 family	-	-	-	ko:K09791	-	-	-	-	ko00000	-	-	-	Trm112p
HKD2_k127_1606267_3	1288494.EBAPG3_2370	2.225e-108	373.0	28H91@1|root,2Z7KU@2|Bacteria,1R4NB@1224|Proteobacteria,2VS45@28216|Betaproteobacteria,373Z4@32003|Nitrosomonadales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1606267_0	1167006.UWK_02355	0.0	1401.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,42MW3@68525|delta/epsilon subdivisions,2WJRZ@28221|Deltaproteobacteria,2MJ97@213118|Desulfobacterales	28221|Deltaproteobacteria	G	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate	ppsA	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
HKD2_k127_1606267_9	1121403.AUCV01000001_gene968	1.493e-28	121.0	COG1109@1|root,COG1109@2|Bacteria,1QUGD@1224|Proteobacteria,43BUU@68525|delta/epsilon subdivisions,2WKYP@28221|Deltaproteobacteria,2MPVX@213118|Desulfobacterales	28221|Deltaproteobacteria	G	Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III	-	-	5.4.2.2,5.4.2.8	ko:K01835,ko:K01840	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114,M00549	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
HKD2_k127_1631078_8	118168.MC7420_4781	0.0001125	48.0	COG2929@1|root,COG2929@2|Bacteria	2|Bacteria	S	Ribonuclease toxin, BrnT, of type II toxin-antitoxin system	-	-	-	ko:K09803	-	-	-	-	ko00000	-	-	-	BrnT_toxin
HKD2_k127_1631078_6	338966.Ppro_1845	2.096e-46	168.0	COG3514@1|root,COG3514@2|Bacteria	2|Bacteria	S	BrnA antitoxin of type II toxin-antitoxin system	-	-	-	-	-	-	-	-	-	-	-	-	BrnA_antitoxin
HKD2_k127_1631078_5	177439.DP0917	2.653e-54	201.0	COG0655@1|root,COG0655@2|Bacteria,1NANP@1224|Proteobacteria,42Q16@68525|delta/epsilon subdivisions,2WIJ7@28221|Deltaproteobacteria,2MIC1@213118|Desulfobacterales	28221|Deltaproteobacteria	T	PFAM NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red,LMWPc
HKD2_k127_1631078_2	1167006.UWK_02733	1.415e-179	576.0	COG1640@1|root,COG1640@2|Bacteria,1QTVJ@1224|Proteobacteria,42PZB@68525|delta/epsilon subdivisions,2WK77@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	PFAM glycoside hydrolase, family 77	malQ	-	2.4.1.25	ko:K00705	ko00500,ko01100,map00500,map01100	-	R05196	RC00049	ko00000,ko00001,ko01000	-	GH77	-	Glyco_hydro_77
HKD2_k127_1631078_0	1121403.AUCV01000010_gene1330	2.21e-236	737.0	COG0568@1|root,COG0568@2|Bacteria,1MXGX@1224|Proteobacteria,42PIS@68525|delta/epsilon subdivisions,2WKSS@28221|Deltaproteobacteria,2MPU3@213118|Desulfobacterales	28221|Deltaproteobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	-	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
HKD2_k127_1631078_1	1121403.AUCV01000010_gene1331	1.805e-190	599.0	COG1060@1|root,COG1060@2|Bacteria,1QN23@1224|Proteobacteria,42M6Z@68525|delta/epsilon subdivisions,2WJ4C@28221|Deltaproteobacteria,2MIGE@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate	mqnE	-	1.21.98.1,2.5.1.120,2.5.1.77	ko:K11779,ko:K11784,ko:K18285	ko00130,ko00680,ko01110,ko01120,map00130,map00680,map01110,map01120	M00378	R08588,R09396,R10667	RC00021,RC01381,RC02329,RC03002,RC03007,RC03234	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_3391	Radical_SAM
HKD2_k127_1631078_3	589865.DaAHT2_0567	2.421e-172	546.0	COG1060@1|root,COG1060@2|Bacteria,1MX50@1224|Proteobacteria,42M6U@68525|delta/epsilon subdivisions,2WJ6Y@28221|Deltaproteobacteria,2MJ4P@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2)	mqnC	-	1.21.98.1	ko:K11784	ko00130,ko01110,map00130,map01110	-	R08588	RC02329	ko00000,ko00001,ko01000	-	-	-	Radical_SAM
HKD2_k127_1631078_4	1121403.AUCV01000010_gene1333	1.24e-98	336.0	COG0402@1|root,COG0402@2|Bacteria,1MVPA@1224|Proteobacteria,42MJ7@68525|delta/epsilon subdivisions,2WIRS@28221|Deltaproteobacteria,2MJ0J@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Amidohydrolase family	-	-	3.5.4.40	ko:K20810	ko00130,ko01110,map00130,map01110	-	R10695	RC00477	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
HKD2_k127_1631078_7	1167006.UWK_02738	2.216e-41	162.0	COG1427@1|root,COG1427@2|Bacteria,1RCS0@1224|Proteobacteria,42SPW@68525|delta/epsilon subdivisions,2WP7F@28221|Deltaproteobacteria,2MIFZ@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)	mqnA	-	4.2.1.151	ko:K11782	ko00130,ko01110,map00130,map01110	-	R10666	RC03232	ko00000,ko00001,ko01000	-	-	-	VitK2_biosynth
HKD2_k127_1668799_3	1121403.AUCV01000034_gene3838	4.701e-73	254.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
HKD2_k127_1668799_4	1167006.UWK_01889	2.627e-65	238.0	COG2861@1|root,COG2861@2|Bacteria,1N3JP@1224|Proteobacteria,42RJN@68525|delta/epsilon subdivisions,2WNEI@28221|Deltaproteobacteria,2MJKY@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Divergent polysaccharide deacetylase	yibQ	-	-	ko:K09798	-	-	-	-	ko00000	-	-	-	Polysacc_deac_2
HKD2_k127_1668799_2	1167006.UWK_01888	9.781e-87	298.0	COG0142@1|root,COG0142@2|Bacteria,1MUK6@1224|Proteobacteria,42M1B@68525|delta/epsilon subdivisions,2WK2M@28221|Deltaproteobacteria,2MJ27@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Belongs to the FPP GGPP synthase family	ispB	-	2.5.1.1,2.5.1.10,2.5.1.29,2.5.1.90	ko:K02523,ko:K13789	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00366	R01658,R02003,R02061,R09248	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
HKD2_k127_1668799_0	1121403.AUCV01000020_gene3129	8.114e-248	782.0	COG1199@1|root,COG1199@2|Bacteria,1MVCU@1224|Proteobacteria,42N57@68525|delta/epsilon subdivisions,2WJ82@28221|Deltaproteobacteria,2MNKS@213118|Desulfobacterales	28221|Deltaproteobacteria	KL	HELICc2	yoaA	-	3.6.4.12	ko:K03722	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_2,Helicase_C_2,ResIII
HKD2_k127_1668799_1	1121403.AUCV01000020_gene3127	7.38e-91	306.0	COG0745@1|root,COG4191@1|root,COG0745@2|Bacteria,COG4191@2|Bacteria,1R13R@1224|Proteobacteria,43D5Z@68525|delta/epsilon subdivisions,2X8CS@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HATPase_c,HisKA,Response_reg
HKD2_k127_1671110_2	177439.DP0975	2.255e-47	179.0	2E00X@1|root,32VQ9@2|Bacteria,1NZY3@1224|Proteobacteria,431M9@68525|delta/epsilon subdivisions,2WWPN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1671110_1	1121403.AUCV01000002_gene546	1.43e-94	314.0	COG0569@1|root,COG0569@2|Bacteria,1R7KM@1224|Proteobacteria,42PJH@68525|delta/epsilon subdivisions,2WMZT@28221|Deltaproteobacteria,2MJ9H@213118|Desulfobacterales	28221|Deltaproteobacteria	P	PFAM TrkA-N domain	ktrA	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
HKD2_k127_1671110_0	177439.DP0973	1.356e-175	573.0	COG0168@1|root,COG0168@2|Bacteria,1N412@1224|Proteobacteria,42MBI@68525|delta/epsilon subdivisions,2WIZ9@28221|Deltaproteobacteria,2MI8M@213118|Desulfobacterales	28221|Deltaproteobacteria	P	TIGRFAM potassium uptake protein, TrkH family	ktrB	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
HKD2_k127_1682125_3	1121403.AUCV01000001_gene852	7.099e-103	341.0	COG1253@1|root,COG1253@2|Bacteria,1MV3P@1224|Proteobacteria,42QX1@68525|delta/epsilon subdivisions,2WMNH@28221|Deltaproteobacteria,2MPSY@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Transporter associated domain	corC	-	-	ko:K06189	-	-	-	-	ko00000,ko02000	9.A.40.1.2	-	-	CBS,CorC_HlyC,DUF21
HKD2_k127_1682125_0	1121403.AUCV01000001_gene853	1.718e-147	490.0	COG0815@1|root,COG0815@2|Bacteria,1MUBU@1224|Proteobacteria,42MPS@68525|delta/epsilon subdivisions,2WIUD@28221|Deltaproteobacteria,2MHWP@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Transfers the fatty acyl group on membrane lipoproteins	lnt	-	-	ko:K03820	-	-	-	-	ko00000,ko01000	-	GT2	-	CN_hydrolase
HKD2_k127_1682125_1	1121403.AUCV01000032_gene2880	2.205e-145	471.0	COG2195@1|root,COG2195@2|Bacteria,1MV7D@1224|Proteobacteria,42MBD@68525|delta/epsilon subdivisions,2WJT1@28221|Deltaproteobacteria,2MI62@213118|Desulfobacterales	28221|Deltaproteobacteria	E	TIGRFAM peptidase T-like protein	-	-	3.4.11.4	ko:K01258	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
HKD2_k127_1682125_2	177439.DP0257	1.516e-114	385.0	COG0245@1|root,COG1211@1|root,COG0245@2|Bacteria,COG1211@2|Bacteria,1MVHA@1224|Proteobacteria,42MJ6@68525|delta/epsilon subdivisions,2WJ67@28221|Deltaproteobacteria,2MJZP@213118|Desulfobacterales	28221|Deltaproteobacteria	I	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP)	ispF	-	2.7.7.60,4.6.1.12	ko:K01770,ko:K12506	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633,R05637	RC00002,RC01440	ko00000,ko00001,ko00002,ko01000	-	-	-	IspD,YgbB
HKD2_k127_1682125_4	1150626.PHAMO_10077	2.482e-08	61.0	2DI18@1|root,301P8@2|Bacteria,1PTHJ@1224|Proteobacteria,2V5D3@28211|Alphaproteobacteria,2JYAW@204441|Rhodospirillales	204441|Rhodospirillales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1682125_5	1121403.AUCV01000032_gene2883	0.0001499	45.0	COG0328@1|root,COG0328@2|Bacteria,1MZD1@1224|Proteobacteria,42UI6@68525|delta/epsilon subdivisions,2WQSU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	Ribonuclease H	rnhA	-	3.1.26.4	ko:K03469	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RVT_3
HKD2_k127_1709756_10	1232410.KI421418_gene2168	1.176e-15	78.0	2DG4U@1|root,2ZUHZ@2|Bacteria,1P7P1@1224|Proteobacteria,432VB@68525|delta/epsilon subdivisions,2WXHT@28221|Deltaproteobacteria,43VWC@69541|Desulfuromonadales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1709756_2	1167006.UWK_02308	1.32e-112	373.0	COG0348@1|root,COG0348@2|Bacteria,1MY5M@1224|Proteobacteria,42QNC@68525|delta/epsilon subdivisions,2WMUV@28221|Deltaproteobacteria,2MN64@213118|Desulfobacterales	28221|Deltaproteobacteria	C	4Fe-4S binding domain	yccM-1	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_10,Fer4_5
HKD2_k127_1709756_5	459349.CLOAM1515	3.707e-84	289.0	COG1313@1|root,COG1313@2|Bacteria,2NP6I@2323|unclassified Bacteria	2|Bacteria	C	Radical SAM superfamily	pflX	-	1.97.1.4	ko:K04070	-	-	-	-	ko00000,ko01000	-	-	-	Fer4_12,Fer4_14,Radical_SAM
HKD2_k127_1709756_8	1167006.UWK_01772	6.509e-47	172.0	COG0347@1|root,COG0347@2|Bacteria,1RGWK@1224|Proteobacteria,42SJJ@68525|delta/epsilon subdivisions,2WP4E@28221|Deltaproteobacteria,2MK8A@213118|Desulfobacterales	28221|Deltaproteobacteria	K	Belongs to the P(II) protein family	-	-	-	ko:K04751	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	P-II
HKD2_k127_1709756_3	338966.Ppro_2228	2.408e-96	331.0	COG0745@1|root,COG0745@2|Bacteria,1MVCB@1224|Proteobacteria,42QPB@68525|delta/epsilon subdivisions,2WMP0@28221|Deltaproteobacteria,43T71@69541|Desulfuromonadales	28221|Deltaproteobacteria	K	response regulator	-	-	-	ko:K07664	ko02020,map02020	M00450,M00645,M00646,M00648	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
HKD2_k127_1709756_1	1232410.KI421418_gene2172	2.593e-156	508.0	COG0642@1|root,COG2205@2|Bacteria,1N17V@1224|Proteobacteria,42ND1@68525|delta/epsilon subdivisions,2X753@28221|Deltaproteobacteria,43VYU@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	2.7.13.3	ko:K07642	ko02020,map02020	M00450,M00645,M00646,M00648	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
HKD2_k127_1709756_4	589865.DaAHT2_0189	4.93e-91	309.0	COG0457@1|root,COG3271@1|root,COG0457@2|Bacteria,COG3271@2|Bacteria,1RA3D@1224|Proteobacteria,43D5Q@68525|delta/epsilon subdivisions	1224|Proteobacteria	S	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C39_2,TPR_16
HKD2_k127_1709756_9	1123368.AUIS01000005_gene396	2.747e-29	123.0	2E445@1|root,32Z0E@2|Bacteria,1N7FY@1224|Proteobacteria,1SDJE@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1709756_0	1121403.AUCV01000005_gene341	6.559e-179	564.0	COG0057@1|root,COG0057@2|Bacteria,1MU93@1224|Proteobacteria,42N9Q@68525|delta/epsilon subdivisions,2WIK1@28221|Deltaproteobacteria,2MIIT@213118|Desulfobacterales	28221|Deltaproteobacteria	G	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family	gap	-	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Gp_dh_C,Gp_dh_N
HKD2_k127_1709756_6	1121403.AUCV01000005_gene340	2.239e-65	234.0	2C469@1|root,33HZ0@2|Bacteria,1NNDA@1224|Proteobacteria,42R4S@68525|delta/epsilon subdivisions,2WMQQ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1709756_7	1121403.AUCV01000005_gene339	8.131e-49	179.0	COG0297@1|root,COG0297@2|Bacteria,1MUGM@1224|Proteobacteria,42MT8@68525|delta/epsilon subdivisions,2WITI@28221|Deltaproteobacteria,2MKJ1@213118|Desulfobacterales	28221|Deltaproteobacteria	G	synthase	glgA	GO:0000271,GO:0003674,GO:0003824,GO:0004373,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0008194,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0035251,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046527,GO:0055114,GO:0071704,GO:1901576	2.4.1.21	ko:K00703	ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026	M00565	R02421	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT5	-	Glyco_transf_5,Glycos_transf_1
HKD2_k127_1725144_9	234267.Acid_3697	9.899e-22	103.0	COG1287@1|root,COG1287@2|Bacteria,3Y5FJ@57723|Acidobacteria	57723|Acidobacteria	S	oligosaccharyl transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1725144_6	1121406.JAEX01000005_gene3143	4.711e-71	249.0	COG0483@1|root,COG0483@2|Bacteria,1MUQT@1224|Proteobacteria,42R1W@68525|delta/epsilon subdivisions,2WMQ4@28221|Deltaproteobacteria,2M97T@213115|Desulfovibrionales	28221|Deltaproteobacteria	G	PFAM inositol monophosphatase	suhB	-	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
HKD2_k127_1725144_5	1121403.AUCV01000069_gene2307	8.3e-102	345.0	COG0697@1|root,COG0697@2|Bacteria,1P3V0@1224|Proteobacteria,42ST9@68525|delta/epsilon subdivisions,2WN9H@28221|Deltaproteobacteria,2MJVX@213118|Desulfobacterales	28221|Deltaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HKD2_k127_1725144_4	933262.AXAM01000001_gene374	6.207e-111	362.0	COG0284@1|root,COG0284@2|Bacteria,1MW2C@1224|Proteobacteria,42N5N@68525|delta/epsilon subdivisions,2WMJ5@28221|Deltaproteobacteria,2MHNM@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)	pyrF	GO:0003674,GO:0003824,GO:0004590,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006207,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019856,GO:0034641,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.1.23	ko:K01591	ko00240,ko01100,map00240,map01100	M00051	R00965	RC00409	ko00000,ko00001,ko00002,ko01000	-	-	-	OMPdecase
HKD2_k127_1725144_10	221288.JH992901_gene4704	1.082e-10	65.0	COG2104@1|root,COG2104@2|Bacteria,1G986@1117|Cyanobacteria,1JIYV@1189|Stigonemataceae	1117|Cyanobacteria	H	ThiS family	thiS	-	-	ko:K03154	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	iJN678.ycf40	ThiS
HKD2_k127_1725144_3	1167006.UWK_01893	2.893e-117	382.0	COG2022@1|root,COG2022@2|Bacteria,1N0N5@1224|Proteobacteria,42MNC@68525|delta/epsilon subdivisions,2WIUI@28221|Deltaproteobacteria,2MIPN@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S	thiG	GO:0003674,GO:0003824,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.8.1.10	ko:K03149	ko00730,ko01100,map00730,map01100	-	R10247	RC03096,RC03097,RC03461	ko00000,ko00001,ko01000	-	-	-	ThiG
HKD2_k127_1725144_2	1167006.UWK_01892	1.796e-160	512.0	COG0502@1|root,COG0502@2|Bacteria,1MXK0@1224|Proteobacteria,42M3U@68525|delta/epsilon subdivisions,2WJQ6@28221|Deltaproteobacteria,2MHKZ@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Biotin and Thiamin Synthesis associated	thiH	-	4.1.99.19	ko:K03150	ko00730,ko01100,map00730,map01100	-	R10246	RC01434,RC03095	ko00000,ko00001,ko01000	-	-	-	BATS,Radical_SAM
HKD2_k127_1725144_8	1121129.KB903360_gene3560	2.466e-35	137.0	COG0399@1|root,COG0399@2|Bacteria,4NVFZ@976|Bacteroidetes,2FV56@200643|Bacteroidia,22YVB@171551|Porphyromonadaceae	976|Bacteroidetes	J	23S rRNA-intervening sequence protein	-	-	-	-	-	-	-	-	-	-	-	-	23S_rRNA_IVP
HKD2_k127_1725144_0	589865.DaAHT2_1420	3.368e-233	727.0	COG0138@1|root,COG0138@2|Bacteria,1MUDQ@1224|Proteobacteria,42MV4@68525|delta/epsilon subdivisions,2WKHZ@28221|Deltaproteobacteria,2MI2I@213118|Desulfobacterales	28221|Deltaproteobacteria	F	PFAM AICARFT IMPCHase bienzyme	purH	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AICARFT_IMPCHas,MGS
HKD2_k127_1725144_7	635013.TherJR_2300	3.3e-63	222.0	COG0840@1|root,COG0840@2|Bacteria	2|Bacteria	NT	transmembrane signaling receptor activity	-	-	-	ko:K02660,ko:K03406,ko:K03776,ko:K11525	ko02020,ko02025,ko02030,map02020,map02025,map02030	-	-	-	ko00000,ko00001,ko02035,ko02044	-	-	-	GAF,HAMP,MCPsignal,PAS_3,PilZ,dCache_1
HKD2_k127_1725144_1	273068.TTE1708	1.249e-203	647.0	COG0369@1|root,COG1151@2|Bacteria,1TRSC@1239|Firmicutes,248HQ@186801|Clostridia,42EP3@68295|Thermoanaerobacterales	186801|Clostridia	C	TIGRFAM Carbon-monoxide dehydrogenase, catalytic subunit	-	-	1.2.7.4	ko:K00198	ko00633,ko00680,ko00720,ko01120,ko01200,map00633,map00680,map00720,map01120,map01200	M00377	R07157,R08034	RC00250,RC02800	ko00000,ko00001,ko00002,ko01000	-	-	-	Prismane
HKD2_k127_1739113_1	880072.Desac_2637	1.249e-126	419.0	COG5002@1|root,COG5002@2|Bacteria,1MWF3@1224|Proteobacteria,42NB5@68525|delta/epsilon subdivisions,2WJGX@28221|Deltaproteobacteria,2MQCA@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	Signal transduction histidine kinase	phoR	-	2.7.13.3	ko:K07636	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_8,sCache_like
HKD2_k127_1739113_0	572477.Alvin_0381	3.483e-139	444.0	COG1117@1|root,COG1117@2|Bacteria,1MU16@1224|Proteobacteria,1RNUF@1236|Gammaproteobacteria,1WWM1@135613|Chromatiales	135613|Chromatiales	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	pstB	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
HKD2_k127_1745512_0	1167006.UWK_02541	2.039e-202	650.0	COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,1MV1V@1224|Proteobacteria,42N5S@68525|delta/epsilon subdivisions,2WIUS@28221|Deltaproteobacteria,2MMGR@213118|Desulfobacterales	28221|Deltaproteobacteria	T	CHASE2	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	CHASE2,Guanylate_cyc
HKD2_k127_1745512_1	1167006.UWK_02542	2.471e-100	336.0	COG4783@1|root,COG4783@2|Bacteria,1R84W@1224|Proteobacteria,42QAH@68525|delta/epsilon subdivisions,2WKH8@28221|Deltaproteobacteria,2MMU5@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Peptidase family M48	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
HKD2_k127_1745512_3	1499967.BAYZ01000131_gene366	3.465e-33	132.0	COG3807@1|root,COG3807@2|Bacteria,2NRZY@2323|unclassified Bacteria	2|Bacteria	S	Src homology 3 domains	yrvJ	-	3.2.1.96,3.4.17.14,3.5.1.28	ko:K01227,ko:K01447,ko:K01448,ko:K06385,ko:K07260,ko:K11060,ko:K11062,ko:K21472	ko00511,ko00550,ko01100,ko01502,ko01503,ko02020,map00511,map00550,map01100,map01502,map01503,map02020	M00651,M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504,ko02042,ko03036	-	-	-	Amidase_3,Glucosaminidase,NLPC_P60,SH3_3,SH3_4
HKD2_k127_1745512_2	439235.Dalk_0216	9.83e-63	228.0	2CIBN@1|root,2Z8JT@2|Bacteria,1QGIJ@1224|Proteobacteria,42S2V@68525|delta/epsilon subdivisions,2WNZ1@28221|Deltaproteobacteria,2MNS8@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_179165_4	1121403.AUCV01000025_gene2226	8.019e-13	68.0	COG1674@1|root,COG1674@2|Bacteria,1MVPI@1224|Proteobacteria,42N4X@68525|delta/epsilon subdivisions,2WIPR@28221|Deltaproteobacteria,2MI69@213118|Desulfobacterales	28221|Deltaproteobacteria	D	DNA segregation ATPase, FtsK SpoIIIE family	ftsK	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
HKD2_k127_179165_3	1121403.AUCV01000025_gene2228	9.856e-87	287.0	COG1146@1|root,COG1146@2|Bacteria,1RC9N@1224|Proteobacteria,42QXF@68525|delta/epsilon subdivisions,2WMRJ@28221|Deltaproteobacteria,2MJFT@213118|Desulfobacterales	28221|Deltaproteobacteria	C	reductase, beta subunit	aprB	-	1.8.99.2	ko:K00395	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00596	R00860,R04927,R08553	RC00007,RC01239,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	-	APS-reductase_C,Fer4,Fer4_9
HKD2_k127_179165_0	1121403.AUCV01000025_gene2229	0.0	1295.0	COG1053@1|root,COG1053@2|Bacteria,1NZBR@1224|Proteobacteria,42PSJ@68525|delta/epsilon subdivisions,2WJDD@28221|Deltaproteobacteria,2MHWQ@213118|Desulfobacterales	28221|Deltaproteobacteria	C	reductase, alpha subunit	aprA	-	1.8.99.2	ko:K00394	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00596	R00860,R04927,R08553	RC00007,RC01239,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2
HKD2_k127_179165_2	1121403.AUCV01000025_gene2230	7.548e-219	686.0	COG1148@1|root,COG1148@2|Bacteria,1Q0ZF@1224|Proteobacteria,42NHH@68525|delta/epsilon subdivisions,2WJ6M@28221|Deltaproteobacteria,2MIS1@213118|Desulfobacterales	28221|Deltaproteobacteria	C	FAD dependent oxidoreductase	qmoA	-	-	ko:K16885	-	-	-	-	ko00000	-	-	-	FAD_oxidored,NAD_binding_8,Pyr_redox_2
HKD2_k127_179165_1	1121403.AUCV01000025_gene2231	2.084e-272	849.0	COG1148@1|root,COG1908@1|root,COG1148@2|Bacteria,COG1908@2|Bacteria,1MWAG@1224|Proteobacteria,42NNE@68525|delta/epsilon subdivisions,2WJZX@28221|Deltaproteobacteria,2MI6X@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Methyl-viologen-reducing hydrogenase, delta subunit	qmoB	-	-	ko:K16886	-	-	-	-	ko00000	-	-	-	Fer4,Fer4_9,FlpD,Pyr_redox_2
HKD2_k127_183959_4	335543.Sfum_3654	3.59e-47	178.0	COG0193@1|root,COG0193@2|Bacteria,1MX1P@1224|Proteobacteria,42RGU@68525|delta/epsilon subdivisions,2WPHH@28221|Deltaproteobacteria,2MQJP@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis	pth	GO:0003674,GO:0003824,GO:0004045,GO:0016787,GO:0016788,GO:0052689,GO:0140098,GO:0140101	3.1.1.29	ko:K01056	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	Pept_tRNA_hydro
HKD2_k127_183959_1	96561.Dole_2417	5.515e-128	431.0	COG0457@1|root,COG1807@1|root,COG0457@2|Bacteria,COG1807@2|Bacteria,1NFQW@1224|Proteobacteria,42MT2@68525|delta/epsilon subdivisions,2WKWA@28221|Deltaproteobacteria,2MJFK@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Tetratricopeptide TPR_2 repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_11,TPR_16,TPR_2,TPR_4,TPR_8
HKD2_k127_183959_3	1121403.AUCV01000008_gene1588	4.532e-67	239.0	COG1329@1|root,COG1329@2|Bacteria,1MWI2@1224|Proteobacteria,42RXS@68525|delta/epsilon subdivisions,2WNA0@28221|Deltaproteobacteria,2MJTK@213118|Desulfobacterales	28221|Deltaproteobacteria	K	PFAM transcription factor CarD	-	-	-	ko:K07736	-	-	-	-	ko00000,ko03000	-	-	-	CarD_CdnL_TRCF
HKD2_k127_183959_2	589865.DaAHT2_0604	4.236e-91	310.0	COG0564@1|root,COG0564@2|Bacteria,1MUBN@1224|Proteobacteria,42MBA@68525|delta/epsilon subdivisions,2WKX9@28221|Deltaproteobacteria,2MI4G@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Responsible for synthesis of pseudouridine from uracil	rluD	-	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
HKD2_k127_183959_5	589865.DaAHT2_0605	1.133e-41	166.0	COG0237@1|root,COG0237@2|Bacteria,1RCXT@1224|Proteobacteria,42RI5@68525|delta/epsilon subdivisions,2WPDF@28221|Deltaproteobacteria,2MK2V@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A	coaE	GO:0003674,GO:0003824,GO:0004140,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.1.24	ko:K00859	ko00770,ko01100,map00770,map01100	M00120	R00130	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	CoaE
HKD2_k127_183959_0	1121403.AUCV01000008_gene1591	8.714e-235	730.0	COG1158@1|root,COG1158@2|Bacteria,1MUCF@1224|Proteobacteria,42M15@68525|delta/epsilon subdivisions,2WIQN@28221|Deltaproteobacteria,2MI44@213118|Desulfobacterales	28221|Deltaproteobacteria	K	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template	rho	-	-	ko:K03628	ko03018,map03018	-	-	-	ko00000,ko00001,ko03019,ko03021	-	-	-	ATP-synt_ab,Rho_N,Rho_RNA_bind
HKD2_k127_183959_6	177439.DP2727	1.822e-29	118.0	COG0254@1|root,COG0254@2|Bacteria,1PT0H@1224|Proteobacteria,42V2Z@68525|delta/epsilon subdivisions,2WRGA@28221|Deltaproteobacteria,2MM5X@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Binds the 23S rRNA	rpmE	-	-	ko:K02909	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L31
HKD2_k127_1872027_0	1266908.AQPB01000059_gene2665	1.72e-163	534.0	COG0642@1|root,COG2206@1|root,COG2205@2|Bacteria,COG2206@2|Bacteria,1RAQS@1224|Proteobacteria,1S4K4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CBS,GAF_2,HD,HD_5,PAS_4,PAS_9
HKD2_k127_1872027_1	1163617.SCD_n01899	2.978e-37	141.0	COG0324@1|root,COG0324@2|Bacteria,1MUB2@1224|Proteobacteria,2VHEP@28216|Betaproteobacteria	28216|Betaproteobacteria	J	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)	miaA	-	2.5.1.75	ko:K00791	ko00908,ko01100,ko01110,map00908,map01100,map01110	-	R01122	RC02820	ko00000,ko00001,ko01000,ko01006,ko03016	-	-	-	IPPT
HKD2_k127_191085_1	1121403.AUCV01000020_gene3075	4.522e-24	111.0	COG3031@1|root,COG3031@2|Bacteria,1PUWN@1224|Proteobacteria,42T73@68525|delta/epsilon subdivisions,2WPQU@28221|Deltaproteobacteria,2MK5Q@213118|Desulfobacterales	28221|Deltaproteobacteria	U	General secretion pathway protein C	gspC	-	-	ko:K02452	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	PDZ_2,T2SSC
HKD2_k127_191085_0	1121403.AUCV01000020_gene3074	1.135e-94	327.0	COG0457@1|root,COG1450@1|root,COG0457@2|Bacteria,COG1450@2|Bacteria,1MUUA@1224|Proteobacteria,42M9I@68525|delta/epsilon subdivisions,2WK1H@28221|Deltaproteobacteria,2MIEH@213118|Desulfobacterales	28221|Deltaproteobacteria	NU	type II and III secretion system protein	gspD	-	-	ko:K02453	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	Secretin,Secretin_N
HKD2_k127_1920365_0	1167006.UWK_02898	5.041e-312	964.0	COG1038@1|root,COG1038@2|Bacteria,1R7P1@1224|Proteobacteria,42PQ3@68525|delta/epsilon subdivisions,2WJK5@28221|Deltaproteobacteria,2MJRR@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Conserved carboxylase domain	-	-	6.4.1.1	ko:K01958	ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230	M00173	R00344	RC00040,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_lipoyl,HMGL-like,PYC_OADA
HKD2_k127_1920365_1	1167006.UWK_02897	5.13e-235	734.0	COG0439@1|root,COG0439@2|Bacteria,1MU4H@1224|Proteobacteria,42M14@68525|delta/epsilon subdivisions,2WIN7@28221|Deltaproteobacteria,2MHYZ@213118|Desulfobacterales	28221|Deltaproteobacteria	I	PFAM Carbamoyl-phosphate synthase L chain	accC	-	6.3.4.14,6.4.1.1,6.4.1.2	ko:K01959,ko:K01961	ko00020,ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko01230,map00020,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212,map01230	M00082,M00173,M00376,M00620	R00344,R00742,R04385	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
HKD2_k127_1978161_6	1121403.AUCV01000034_gene3844	4.953e-46	169.0	COG1968@1|root,COG1968@2|Bacteria,1MX02@1224|Proteobacteria,42N67@68525|delta/epsilon subdivisions,2WPKC@28221|Deltaproteobacteria,2MJE6@213118|Desulfobacterales	28221|Deltaproteobacteria	V	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin	uppP	-	3.6.1.27	ko:K06153	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	BacA
HKD2_k127_1978161_4	1121403.AUCV01000034_gene3843	1.133e-77	269.0	COG2230@1|root,COG2230@2|Bacteria,1R13U@1224|Proteobacteria,43D61@68525|delta/epsilon subdivisions,2X8CU@28221|Deltaproteobacteria,2MPN9@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Lysine methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_16
HKD2_k127_1978161_5	589865.DaAHT2_2550	1.499e-52	193.0	COG1648@1|root,COG1648@2|Bacteria,1RB3H@1224|Proteobacteria,42QT2@68525|delta/epsilon subdivisions,2WN1F@28221|Deltaproteobacteria,2MJPS@213118|Desulfobacterales	28221|Deltaproteobacteria	H	TIGRFAM siroheme synthase	cysG	-	1.3.1.76,4.99.1.4	ko:K02304	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02864,R03947	RC01012,RC01034	ko00000,ko00001,ko00002,ko01000	-	-	-	NAD_binding_7,Sirohm_synth_M
HKD2_k127_1978161_3	1125863.JAFN01000001_gene1124	3.045e-83	286.0	COG0755@1|root,COG0755@2|Bacteria,1RCCI@1224|Proteobacteria,42PVM@68525|delta/epsilon subdivisions,2WJ7I@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	PFAM Cytochrome c assembly protein	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C_asm
HKD2_k127_1978161_1	1121403.AUCV01000034_gene3840	2.639e-171	548.0	COG0373@1|root,COG0373@2|Bacteria,1MU41@1224|Proteobacteria,42MUG@68525|delta/epsilon subdivisions,2WISB@28221|Deltaproteobacteria,2MIIU@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)	hemA	-	1.2.1.70	ko:K02492	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R04109	RC00055,RC00149	ko00000,ko00001,ko00002,ko01000	-	-	-	GlutR_N,GlutR_dimer,Shikimate_DH
HKD2_k127_1978161_0	572477.Alvin_1133	1.753e-230	734.0	COG1866@1|root,COG1866@2|Bacteria,1MWXN@1224|Proteobacteria,1RPM0@1236|Gammaproteobacteria,1WWJT@135613|Chromatiales	135613|Chromatiales	H	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA	pckA	-	4.1.1.49	ko:K01610	ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200	M00003,M00170	R00341	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPCK_ATP
HKD2_k127_1978161_2	485915.Dret_1495	5.678e-114	378.0	COG1251@1|root,COG1251@2|Bacteria,1MW58@1224|Proteobacteria,42PSQ@68525|delta/epsilon subdivisions,2WKDY@28221|Deltaproteobacteria,2M8IA@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	1.7.1.15	ko:K00362	ko00910,ko01120,map00910,map01120	M00530	R00787	RC00176	ko00000,ko00001,ko00002,ko01000	-	-	-	Pyr_redox_2
HKD2_k127_1983347_0	1121472.AQWN01000003_gene1589	4.246e-320	1035.0	COG0745@1|root,COG3437@1|root,COG5002@1|root,COG0745@2|Bacteria,COG3437@2|Bacteria,COG5002@2|Bacteria,1VRP7@1239|Firmicutes,24YHW@186801|Clostridia,267E7@186807|Peptococcaceae	186801|Clostridia	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,Hpt,PAS_9,Response_reg
HKD2_k127_1983347_1	485916.Dtox_3785	4.883e-100	336.0	COG1352@1|root,COG1352@2|Bacteria,1TRTF@1239|Firmicutes,24D04@186801|Clostridia,261HW@186807|Peptococcaceae	186801|Clostridia	NT	PFAM CheR methyltransferase, SAM binding domain	-	-	2.1.1.80	ko:K00575	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko01000,ko02035	-	-	-	CheR,CheR_N
HKD2_k127_1983347_6	357804.Ping_3722	3.386e-31	141.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS,PAS_4,PAS_9,Response_reg
HKD2_k127_1983347_2	706587.Desti_5047	1.003e-93	329.0	COG0745@1|root,COG0784@1|root,COG5002@1|root,COG0745@2|Bacteria,COG0784@2|Bacteria,COG5002@2|Bacteria,1NC9X@1224|Proteobacteria,43BSJ@68525|delta/epsilon subdivisions,2X73B@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_9,Response_reg
HKD2_k127_1983347_3	1121472.AQWN01000003_gene1591	6.065e-54	198.0	COG2201@1|root,COG2201@2|Bacteria,1VUR7@1239|Firmicutes,2505U@186801|Clostridia,2650Y@186807|Peptococcaceae	186801|Clostridia	NT	CheB methylesterase	-	-	3.1.1.61,3.5.1.44	ko:K03412	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest
HKD2_k127_1983347_9	1265505.ATUG01000001_gene4219	2.258e-18	90.0	COG2202@1|root,COG3829@1|root,COG2202@2|Bacteria,COG3829@2|Bacteria,1NWNJ@1224|Proteobacteria,42T0I@68525|delta/epsilon subdivisions,2WPGZ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)	-	-	-	-	-	-	-	-	-	-	-	-	PAS_3,PAS_4
HKD2_k127_1983347_7	1120959.ATXF01000004_gene3146	5.473e-30	136.0	COG0584@1|root,COG0584@2|Bacteria,2GNM5@201174|Actinobacteria,4FQIE@85023|Microbacteriaceae	201174|Actinobacteria	C	Glycerophosphoryl diester phosphodiesterase family	-	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD
HKD2_k127_1983347_5	525897.Dbac_2950	8.313e-38	152.0	COG2020@1|root,COG2020@2|Bacteria,1MWU6@1224|Proteobacteria,42X7G@68525|delta/epsilon subdivisions,2WSX9@28221|Deltaproteobacteria,2MDSS@213115|Desulfovibrionales	28221|Deltaproteobacteria	O	methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	NnrU,PEMT
HKD2_k127_1983347_8	1232437.KL661961_gene2948	1.826e-22	103.0	2EG6A@1|root,339Y4@2|Bacteria,1NIH0@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF2007
HKD2_k127_1983347_4	192952.MM_1902	4.889e-51	187.0	COG1247@1|root,arCOG00830@2157|Archaea,2XXA1@28890|Euryarchaeota,2NAY3@224756|Methanomicrobia	224756|Methanomicrobia	K	Acetyltransferase (GNAT) domain	-	-	2.3.1.183	ko:K03823	ko00440,ko01130,map00440,map01130	-	R08871,R08938	RC00004,RC00064	ko00000,ko00001,ko01000	-	-	-	Acetyltransf_4
HKD2_k127_2061749_2	630626.EBL_c08110	1.635e-78	278.0	COG0507@1|root,COG0507@2|Bacteria,1MW43@1224|Proteobacteria,1RPA0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD	recD	GO:0000166,GO:0000724,GO:0000725,GO:0003674,GO:0003824,GO:0004386,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0008854,GO:0009338,GO:0009987,GO:0016462,GO:0016787,GO:0016788,GO:0016796,GO:0016817,GO:0016818,GO:0016887,GO:0016895,GO:0017076,GO:0017111,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0034641,GO:0035639,GO:0036094,GO:0042623,GO:0043142,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363,GO:1902494	3.1.11.5	ko:K03581	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AAA_19,AAA_30,UvrD_C_2
HKD2_k127_2061749_0	1049564.TevJSym_am00280	3.723e-242	789.0	COG1074@1|root,COG1074@2|Bacteria,1MUTF@1224|Proteobacteria,1RPC6@1236|Gammaproteobacteria,1J5BI@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	L	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA	recB	GO:0000166,GO:0000724,GO:0000725,GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0004518,GO:0004519,GO:0004520,GO:0004527,GO:0004529,GO:0004536,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006952,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0008854,GO:0009314,GO:0009338,GO:0009628,GO:0009987,GO:0015616,GO:0016043,GO:0016462,GO:0016787,GO:0016788,GO:0016796,GO:0016817,GO:0016818,GO:0016887,GO:0016895,GO:0017076,GO:0017111,GO:0030554,GO:0032392,GO:0032508,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0034641,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044355,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0097159,GO:0097367,GO:0099046,GO:0140097,GO:1901265,GO:1901360,GO:1901363,GO:1902494	3.1.11.5	ko:K03582	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
HKD2_k127_2061749_1	1286106.MPL1_02678	7.653e-210	690.0	COG1330@1|root,COG1330@2|Bacteria,1MWTI@1224|Proteobacteria,1RNT0@1236|Gammaproteobacteria,45ZUY@72273|Thiotrichales	72273|Thiotrichales	L	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity	recC	-	3.1.11.5	ko:K03583	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_V_gamma
HKD2_k127_2061749_3	224325.AF_2420	4.615e-08	65.0	COG0642@1|root,arCOG06536@1|root,arCOG06192@2157|Archaea,arCOG06536@2157|Archaea,2Y4QT@28890|Euryarchaeota	28890|Euryarchaeota	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	PAS
HKD2_k127_2093469_0	1232410.KI421428_gene968	3.553e-124	407.0	COG0535@1|root,COG0535@2|Bacteria,1R58E@1224|Proteobacteria,42NSA@68525|delta/epsilon subdivisions,2WPAQ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Iron-sulfur cluster-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM,SPASM
HKD2_k127_2093469_3	909663.KI867150_gene475	3.939e-46	173.0	COG2353@1|root,COG2353@2|Bacteria,1R9XD@1224|Proteobacteria,42T4I@68525|delta/epsilon subdivisions,2WPAC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Belongs to the UPF0312 family	-	-	-	-	-	-	-	-	-	-	-	-	YceI
HKD2_k127_2093469_1	1121403.AUCV01000013_gene3919	2.825e-107	363.0	COG3868@1|root,COG3868@2|Bacteria,1PIK8@1224|Proteobacteria,42QZ4@68525|delta/epsilon subdivisions,2WUIV@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Glycoside-hydrolase family GH114	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_114
HKD2_k127_2093469_8	1121456.ATVA01000003_gene3039	8.667e-18	93.0	COG0745@1|root,COG5002@1|root,COG0745@2|Bacteria,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,42NK9@68525|delta/epsilon subdivisions,2X7E0@28221|Deltaproteobacteria,2MHE4@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	PFAM ATP-binding region ATPase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,Hpt,PAS,PAS_4,PAS_9,Response_reg,SBP_bac_3
HKD2_k127_2093469_6	1121396.KB893007_gene4127	6.65e-23	106.0	COG2203@1|root,COG3221@1|root,COG2203@2|Bacteria,COG3221@2|Bacteria	2|Bacteria	P	organic phosphonate transport	-	-	-	ko:K02044	ko02010,map02010	M00223	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.9	-	-	GAF_2,HATPase_c,HTH_41,PAS,PAS_4,Phosphonate-bd,YhfZ_C
HKD2_k127_2093469_7	886293.Sinac_2108	1.364e-18	93.0	COG5485@1|root,COG5485@2|Bacteria,2J0V1@203682|Planctomycetes	203682|Planctomycetes	S	SnoaL-like polyketide cyclase	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL
HKD2_k127_2093469_2	1121405.dsmv_1235	5.027e-99	330.0	COG0412@1|root,COG0412@2|Bacteria,1NKIB@1224|Proteobacteria,43B7J@68525|delta/epsilon subdivisions,2X6KZ@28221|Deltaproteobacteria,2MMAU@213118|Desulfobacterales	28221|Deltaproteobacteria	Q	Dienelactone hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	DLH
HKD2_k127_2093469_5	420324.KI912020_gene7506	2.136e-41	158.0	COG2761@1|root,COG2761@2|Bacteria,1NXUB@1224|Proteobacteria,2TRJ6@28211|Alphaproteobacteria,1JWGR@119045|Methylobacteriaceae	28211|Alphaproteobacteria	Q	DSBA-like thioredoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	DSBA
HKD2_k127_2098106_1	177439.DP1626	1.197e-65	229.0	28NS9@1|root,2ZBRA@2|Bacteria,1RB6V@1224|Proteobacteria,42QVJ@68525|delta/epsilon subdivisions,2WMXS@28221|Deltaproteobacteria,2MNDY@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2098106_0	1121403.AUCV01000033_gene3650	1.192e-126	413.0	COG0714@1|root,COG0714@2|Bacteria,1MUFN@1224|Proteobacteria,42NCX@68525|delta/epsilon subdivisions,2WIYY@28221|Deltaproteobacteria,2MHTK@213118|Desulfobacterales	28221|Deltaproteobacteria	S	ATPase family associated with various cellular activities (AAA)	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
HKD2_k127_2098106_2	1265505.ATUG01000001_gene3745	2.894e-58	219.0	COG1721@1|root,COG1721@2|Bacteria,1R3QD@1224|Proteobacteria,42U4E@68525|delta/epsilon subdivisions,2WQDU@28221|Deltaproteobacteria,2MKSA@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
HKD2_k127_2098106_3	1121403.AUCV01000033_gene3648	3.805e-50	186.0	COG1305@1|root,COG1305@2|Bacteria,1MWCE@1224|Proteobacteria,42NIZ@68525|delta/epsilon subdivisions,2WM5U@28221|Deltaproteobacteria,2MIWN@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Domain of unknown function (DUF3488)	-	-	2.3.2.13	ko:K22452	-	-	-	-	ko00000,ko01000	-	-	-	DUF3488,DUF4129,Transglut_core
HKD2_k127_2125488_1	1167006.UWK_01696	7.914e-292	906.0	COG2905@1|root,COG2905@2|Bacteria,1MW8U@1224|Proteobacteria,42NAX@68525|delta/epsilon subdivisions,2WJF5@28221|Deltaproteobacteria,2MIA9@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Putative nucleotidyltransferase substrate binding domain	-	-	-	ko:K07182	-	-	-	-	ko00000	-	-	-	CBS,DUF294,DUF294_C,PAS_8,cNMP_binding,sCache_2
HKD2_k127_2125488_7	1167006.UWK_01697	7.554e-72	250.0	COG0847@1|root,COG0847@2|Bacteria,1P0GY@1224|Proteobacteria,42R9R@68525|delta/epsilon subdivisions,2WMVH@28221|Deltaproteobacteria,2MPYU@213118|Desulfobacterales	28221|Deltaproteobacteria	L	DNA polymerase III, epsilon subunit	-	-	2.7.7.7	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	RNase_T
HKD2_k127_2125488_8	1167006.UWK_01700	2.217e-55	199.0	COG1335@1|root,COG1335@2|Bacteria,1MU5N@1224|Proteobacteria,42RN4@68525|delta/epsilon subdivisions,2WP37@28221|Deltaproteobacteria,2MK0T@213118|Desulfobacterales	28221|Deltaproteobacteria	Q	PFAM Isochorismatase	-	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
HKD2_k127_2125488_0	1121403.AUCV01000019_gene3250	0.0	1189.0	COG0013@1|root,COG0013@2|Bacteria,1MU9A@1224|Proteobacteria,42M70@68525|delta/epsilon subdivisions,2WJA8@28221|Deltaproteobacteria,2MHQW@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
HKD2_k127_2125488_3	1121403.AUCV01000019_gene3249	4.418e-209	656.0	COG0304@1|root,COG0304@2|Bacteria,1NT86@1224|Proteobacteria,42YK6@68525|delta/epsilon subdivisions,2WUMA@28221|Deltaproteobacteria,2MPTY@213118|Desulfobacterales	28221|Deltaproteobacteria	IQ	Beta-ketoacyl synthase, C-terminal domain	-	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
HKD2_k127_2125488_10	1121403.AUCV01000019_gene3248	2.394e-39	148.0	COG0236@1|root,COG0236@2|Bacteria,1NHIC@1224|Proteobacteria,42X69@68525|delta/epsilon subdivisions,2WSMW@28221|Deltaproteobacteria,2MMFN@213118|Desulfobacterales	28221|Deltaproteobacteria	IQ	Phosphopantetheine attachment site	-	-	-	-	-	-	-	-	-	-	-	-	PP-binding
HKD2_k127_2125488_4	1121403.AUCV01000019_gene3247	1.699e-158	513.0	COG1233@1|root,COG1233@2|Bacteria,1MV2R@1224|Proteobacteria,42NXM@68525|delta/epsilon subdivisions,2WJ2I@28221|Deltaproteobacteria,2MKRK@213118|Desulfobacterales	28221|Deltaproteobacteria	Q	Flavin containing amine oxidoreductase	-	-	1.3.99.26,1.3.99.28,1.3.99.29,1.3.99.31,5.2.1.13	ko:K09835,ko:K10027	ko00906,ko01100,ko01110,map00906,map01100,map01110	M00097	R04787,R04798,R04800,R07512,R09691,R09692	RC01214,RC01960,RC02088,RC02605	ko00000,ko00001,ko00002,ko01000	-	-	-	Amino_oxidase
HKD2_k127_2125488_2	177439.DP2406	2.147e-231	727.0	COG1233@1|root,COG1233@2|Bacteria,1MV2R@1224|Proteobacteria,42NXM@68525|delta/epsilon subdivisions,2WU8Z@28221|Deltaproteobacteria,2MPYB@213118|Desulfobacterales	28221|Deltaproteobacteria	Q	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase,FAD_binding_2
HKD2_k127_2125488_5	1121403.AUCV01000019_gene3245	1.826e-99	330.0	COG1028@1|root,COG1028@2|Bacteria,1MU6X@1224|Proteobacteria,42MB9@68525|delta/epsilon subdivisions,2WJ64@28221|Deltaproteobacteria,2MJ4H@213118|Desulfobacterales	28221|Deltaproteobacteria	IQ	Short-chain dehydrogenase reductase SDR	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HKD2_k127_2125488_9	1121403.AUCV01000019_gene3244	6.525e-46	179.0	COG0764@1|root,COG0764@2|Bacteria,1RH2T@1224|Proteobacteria,42SCN@68525|delta/epsilon subdivisions,2WP3E@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs	fabZ	-	4.2.1.59	ko:K02372	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07764,R10117,R10121	RC00831,RC01095	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FabA
HKD2_k127_2125488_6	1121403.AUCV01000019_gene3243	1.03e-93	310.0	COG0623@1|root,COG0623@2|Bacteria,1NT6W@1224|Proteobacteria,42Z0N@68525|delta/epsilon subdivisions,2WTQ4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	Enoyl-(Acyl carrier protein) reductase	-	-	1.3.1.10,1.3.1.9	ko:K00208	ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212	M00083,M00572	R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671	RC00052,RC00076,RC00120	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HKD2_k127_216905_0	269799.Gmet_0570	4.938e-94	318.0	COG2391@1|root,COG2391@2|Bacteria,1NCH7@1224|Proteobacteria,42NKG@68525|delta/epsilon subdivisions,2WJFC@28221|Deltaproteobacteria,43TGF@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Sulphur transport	-	-	-	ko:K07112	-	-	-	-	ko00000	-	-	-	Sulf_transp
HKD2_k127_216905_4	269799.Gmet_0591	1.526e-31	136.0	COG3420@1|root,COG3420@2|Bacteria	2|Bacteria	P	alginic acid biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,CBM_35,CBM_6,He_PIG,Malectin
HKD2_k127_216905_2	756883.Halar_1087	3.145e-40	167.0	COG0477@1|root,arCOG00130@2157|Archaea	2157|Archaea	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD2_k127_216905_3	1125863.JAFN01000001_gene10	4.25e-32	133.0	COG1732@1|root,COG1732@2|Bacteria,1Q5JK@1224|Proteobacteria,431D7@68525|delta/epsilon subdivisions,2WX5G@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Substrate binding domain of ABC-type glycine betaine transport system	-	-	-	-	-	-	-	-	-	-	-	-	OpuAC
HKD2_k127_2174050_1	639282.DEFDS_2137	7.09e-95	313.0	COG0069@1|root,COG1145@1|root,COG0069@2|Bacteria,COG1145@2|Bacteria,2GEVC@200930|Deferribacteres	200930|Deferribacteres	C	Conserved region in glutamate synthase	-	-	1.4.1.13,1.4.1.14	ko:K00265	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4,GATase_2,GXGXG,Glu_syn_central,Glu_synthase
HKD2_k127_2174050_0	338963.Pcar_2600	2.004e-118	399.0	COG0070@1|root,COG0493@1|root,COG1145@1|root,COG0070@2|Bacteria,COG0493@2|Bacteria,COG1145@2|Bacteria,1PBEZ@1224|Proteobacteria,42NFW@68525|delta/epsilon subdivisions,2WIQE@28221|Deltaproteobacteria,43TK8@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	GXGXG motif	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_20,Fer4_7,GXGXG,Pyr_redox_2,Pyr_redox_3,ThiF
HKD2_k127_2214296_6	1121403.AUCV01000036_gene2938	5.008e-18	85.0	COG2770@1|root,COG2770@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	DUF3365,HAMP,dCache_1
HKD2_k127_2214296_5	177439.DP2509	1.813e-23	106.0	COG0607@1|root,COG0607@2|Bacteria,1RM5B@1224|Proteobacteria,42TBJ@68525|delta/epsilon subdivisions,2WPIJ@28221|Deltaproteobacteria,2MKC8@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Rhodanese-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
HKD2_k127_2214296_3	1121403.AUCV01000018_gene3199	5.625e-50	186.0	COG0745@1|root,COG0745@2|Bacteria	1121403.AUCV01000018_gene3199|-	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2214296_4	1232410.KI421421_gene3305	6.235e-45	174.0	COG2062@1|root,COG2062@2|Bacteria,1N0FX@1224|Proteobacteria,42TJ0@68525|delta/epsilon subdivisions,2WSKD@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Histidine phosphatase superfamily (branch 1)	-	-	-	ko:K08296	-	-	-	-	ko00000,ko01000	-	-	-	His_Phos_1
HKD2_k127_2214296_0	1121403.AUCV01000003_gene1785	2.958e-114	372.0	COG1192@1|root,COG1192@2|Bacteria,1R62T@1224|Proteobacteria	1224|Proteobacteria	D	involved in chromosome partitioning	soj	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
HKD2_k127_2214296_1	1121403.AUCV01000003_gene1784	1.24e-87	305.0	COG5607@1|root,COG5607@2|Bacteria,1NGVB@1224|Proteobacteria,42X7Z@68525|delta/epsilon subdivisions,2WSMB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	CHAD domain	-	-	-	-	-	-	-	-	-	-	-	-	CHAD
HKD2_k127_2217770_0	1265505.ATUG01000002_gene1616	9.8e-213	675.0	COG0493@1|root,COG1148@1|root,COG0493@2|Bacteria,COG1148@2|Bacteria,1MU2H@1224|Proteobacteria,42M6X@68525|delta/epsilon subdivisions,2X6YD@28221|Deltaproteobacteria,2MIN8@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_20,Pyr_redox_2
HKD2_k127_2218851_5	1122931.AUAE01000005_gene3560	6.608e-05	51.0	COG3119@1|root,COG3119@2|Bacteria,4NEFN@976|Bacteroidetes,2FQ6F@200643|Bacteroidia	976|Bacteroidetes	P	Sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	DUF4994,Sulfatase
HKD2_k127_2218851_4	1125863.JAFN01000001_gene1893	2.533e-08	65.0	COG4932@1|root,COG4932@2|Bacteria,1NXZ5@1224|Proteobacteria,430QX@68525|delta/epsilon subdivisions,2WW4R@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2218851_1	269799.Gmet_0591	1.703e-68	247.0	COG3420@1|root,COG3420@2|Bacteria	2|Bacteria	P	alginic acid biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,CBM_35,CBM_6,He_PIG,Malectin
HKD2_k127_2218851_0	269799.Gmet_0591	1.088e-78	273.0	COG3420@1|root,COG3420@2|Bacteria	2|Bacteria	P	alginic acid biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,CBM_35,CBM_6,He_PIG,Malectin
HKD2_k127_2218851_3	768704.Desmer_1347	1.209e-22	115.0	COG2247@1|root,COG3391@1|root,COG2247@2|Bacteria,COG3391@2|Bacteria,1V2E4@1239|Firmicutes,24TKC@186801|Clostridia	186801|Clostridia	M	NHL repeat	-	-	-	-	-	-	-	-	-	-	-	-	NHL
HKD2_k127_2218851_2	448385.sce3387	4.863e-59	232.0	COG4447@1|root,COG4447@2|Bacteria,1R42J@1224|Proteobacteria,42WGC@68525|delta/epsilon subdivisions,2WRHI@28221|Deltaproteobacteria,2YVIP@29|Myxococcales	28221|Deltaproteobacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2239467_3	335543.Sfum_2250	6.125e-05	48.0	COG0726@1|root,COG0726@2|Bacteria,1MX6K@1224|Proteobacteria,42Z2Y@68525|delta/epsilon subdivisions,2WUQF@28221|Deltaproteobacteria,2MRJ7@213462|Syntrophobacterales	28221|Deltaproteobacteria	G	lipopolysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2239467_0	880072.Desac_1400	8.285e-102	340.0	COG0517@1|root,COG2905@1|root,COG0517@2|Bacteria,COG2905@2|Bacteria,1RCSS@1224|Proteobacteria,42QNK@68525|delta/epsilon subdivisions,2WN45@28221|Deltaproteobacteria,2MQUE@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	signal-transduction protein with CBS domains	-	-	-	-	-	-	-	-	-	-	-	-	CBS
HKD2_k127_2239467_1	335543.Sfum_2661	4.191e-52	190.0	COG0517@1|root,COG0517@2|Bacteria,1RI78@1224|Proteobacteria,42SX7@68525|delta/epsilon subdivisions,2WPK5@28221|Deltaproteobacteria,2MRTW@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
HKD2_k127_2239467_2	335543.Sfum_2251	5.323e-34	134.0	COG1063@1|root,COG1063@2|Bacteria,1RB1A@1224|Proteobacteria,42QVR@68525|delta/epsilon subdivisions,2WMTW@28221|Deltaproteobacteria,2MRZ6@213462|Syntrophobacterales	28221|Deltaproteobacteria	E	Alcohol dehydrogenase GroES-like domain	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
HKD2_k127_2240832_2	1121104.AQXH01000004_gene41	4.315e-56	207.0	2C20F@1|root,32R9J@2|Bacteria,4P0SP@976|Bacteroidetes	976|Bacteroidetes	S	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C92
HKD2_k127_2240832_5	196367.JNFG01000037_gene7585	4.134e-30	126.0	2ERVI@1|root,32PBH@2|Bacteria,1PIRW@1224|Proteobacteria,2W7B6@28216|Betaproteobacteria,1KE93@119060|Burkholderiaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2240832_4	1121127.JAFA01000043_gene4187	2.953e-40	155.0	2E5SP@1|root,330H2@2|Bacteria,1NDBY@1224|Proteobacteria,2VXDV@28216|Betaproteobacteria,1K76Z@119060|Burkholderiaceae	28216|Betaproteobacteria	S	YMGG-like Gly-zipper	-	-	-	-	-	-	-	-	-	-	-	-	Gly-zipper_YMGG
HKD2_k127_2240832_0	1167006.UWK_01606	4.382e-167	533.0	COG1091@1|root,COG1091@2|Bacteria	2|Bacteria	M	dTDP-4-dehydrorhamnose reductase activity	rfbD	-	1.1.1.133,5.1.3.26	ko:K00067,ko:K19997	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R02777	RC00182	ko00000,ko00001,ko00002,ko01000	-	-	-	RmlD_sub_bind
HKD2_k127_2240832_3	1121403.AUCV01000032_gene2900	6.436e-52	192.0	COG0149@1|root,COG0149@2|Bacteria	2|Bacteria	G	triose-phosphate isomerase activity	tpiA	GO:0003674,GO:0003824,GO:0004807,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616	5.3.1.1	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01015	RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	TIM
HKD2_k127_2240832_1	589865.DaAHT2_0870	1.44e-105	353.0	COG0476@1|root,COG0476@2|Bacteria,1MW7H@1224|Proteobacteria,42NEC@68525|delta/epsilon subdivisions,2WK08@28221|Deltaproteobacteria,2MK1G@213118|Desulfobacterales	28221|Deltaproteobacteria	H	ThiF family	moeB1	-	2.7.7.80,2.8.1.11	ko:K21147	ko04122,map04122	-	R07459,R07461	RC00043	ko00000,ko00001,ko01000	-	-	-	Rhodanese,ThiF
HKD2_k127_2248673_1	926569.ANT_03460	1.226e-118	384.0	COG1164@1|root,COG1164@2|Bacteria,2G5JB@200795|Chloroflexi	200795|Chloroflexi	E	PFAM peptidase M3A and M3B, thimet oligopeptidase F	-	-	-	ko:K08602	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3,Peptidase_M3_N
HKD2_k127_2248673_6	316274.Haur_4963	4.388e-34	135.0	COG0629@1|root,COG0629@2|Bacteria,2G6YE@200795|Chloroflexi,375QY@32061|Chloroflexia	32061|Chloroflexia	L	Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism	-	-	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
HKD2_k127_2248673_3	452637.Oter_3829	6.218e-47	182.0	COG1524@1|root,COG1524@2|Bacteria,46VXF@74201|Verrucomicrobia,3K93S@414999|Opitutae	414999|Opitutae	S	Metalloenzyme superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
HKD2_k127_2248673_2	1128421.JAGA01000002_gene351	6.847e-107	354.0	COG0414@1|root,COG0414@2|Bacteria,2NP0J@2323|unclassified Bacteria	2|Bacteria	H	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate	panC	GO:0003674,GO:0003824,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006573,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605	6.3.2.1	ko:K01918	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R02473	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_ligase
HKD2_k127_2248673_5	697303.Thewi_1770	2.844e-40	154.0	COG0778@1|root,COG0778@2|Bacteria,1V4DP@1239|Firmicutes,24HBZ@186801|Clostridia,42G3X@68295|Thermoanaerobacterales	186801|Clostridia	C	Putative TM nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	DUF1905,Nitroreductase
HKD2_k127_2248673_4	479434.Sthe_1827	2.336e-43	163.0	COG5483@1|root,COG5483@2|Bacteria	2|Bacteria	S	Protein of unknown function, DUF488	-	-	-	-	-	-	-	-	-	-	-	-	DUF488
HKD2_k127_2248673_8	926569.ANT_04430	3.863e-25	106.0	COG3870@1|root,COG3870@2|Bacteria,2G736@200795|Chloroflexi	200795|Chloroflexi	S	Cyclic-di-AMP receptor	-	-	-	-	-	-	-	-	-	-	-	-	CdAMP_rec
HKD2_k127_2248673_7	926569.ANT_04420	3.097e-31	125.0	COG3870@1|root,COG3870@2|Bacteria	2|Bacteria	S	Cyclic-di-AMP receptor	-	-	-	-	-	-	-	-	-	-	-	-	CdAMP_rec
HKD2_k127_2249821_5	941449.dsx2_2180	4.133e-123	400.0	COG1005@1|root,COG1005@2|Bacteria,1MU2R@1224|Proteobacteria,42MMX@68525|delta/epsilon subdivisions,2WIX8@28221|Deltaproteobacteria,2M82J@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	nuoH	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
HKD2_k127_2249821_2	335543.Sfum_1954	1.537e-234	760.0	COG1034@1|root,COG1034@2|Bacteria,1P8MN@1224|Proteobacteria,42PT5@68525|delta/epsilon subdivisions,2WIPN@28221|Deltaproteobacteria,2MR73@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	TIGRFAM NADH-quinone oxidoreductase, chain G	nuoG-2	-	1.6.5.3	ko:K00336	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer2_4,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
HKD2_k127_2249821_3	941449.dsx2_2178	5.776e-193	611.0	COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,42N6N@68525|delta/epsilon subdivisions,2WJ1W@28221|Deltaproteobacteria,2M833@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	PFAM Respiratory-chain NADH dehydrogenase domain 51 kDa subunit	nuoF-2	-	1.12.1.3,1.6.5.3	ko:K00334,ko:K00335,ko:K18331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx,Complex1_51K,Fer4,NADH_4Fe-4S,SLBB
HKD2_k127_2249821_8	1304872.JAGC01000009_gene324	3.27e-67	232.0	COG1905@1|root,COG1905@2|Bacteria,1MWS2@1224|Proteobacteria,42SED@68525|delta/epsilon subdivisions,2WPP9@28221|Deltaproteobacteria,2M7XW@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit	nuoE-2	-	1.6.5.3	ko:K00334	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
HKD2_k127_2249821_0	941449.dsx2_2176	0.0	1114.0	COG0377@1|root,COG0649@1|root,COG0377@2|Bacteria,COG0649@2|Bacteria,1MVIN@1224|Proteobacteria,42M9G@68525|delta/epsilon subdivisions,2WIS7@28221|Deltaproteobacteria,2M9PP@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoBCD	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044464,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072521,GO:1901135,GO:1901360,GO:1901564	1.6.5.3	ko:K00333,ko:K13378,ko:K13380	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa,Complex1_49kDa,Oxidored_q6
HKD2_k127_2249821_9	1121405.dsmv_1994	2.672e-50	185.0	COG0838@1|root,COG0838@2|Bacteria,1RGUT@1224|Proteobacteria,42U92@68525|delta/epsilon subdivisions,2WQCK@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoA	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0044425,GO:0050136,GO:0055114,GO:0098796,GO:1902494	1.6.5.3	ko:K00330	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q4
HKD2_k127_2249821_1	690850.Desaf_0090	4.646e-255	803.0	COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,42M80@68525|delta/epsilon subdivisions,2WINJ@28221|Deltaproteobacteria,2M9FP@213115|Desulfovibrionales	28221|Deltaproteobacteria	G	PFAM Transketolase	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
HKD2_k127_2249821_10	1443113.LC20_00064	1.032e-15	83.0	COG0582@1|root,COG0582@2|Bacteria,1MU23@1224|Proteobacteria,1RMJ1@1236|Gammaproteobacteria,41ENB@629|Yersinia	1236|Gammaproteobacteria	L	Belongs to the 'phage' integrase family	intS	-	-	-	-	-	-	-	-	-	-	-	Arm-DNA-bind_3,Phage_integrase
HKD2_k127_2249821_6	1121403.AUCV01000004_gene2014	3.152e-104	346.0	COG0106@1|root,COG0106@2|Bacteria,1R6J2@1224|Proteobacteria,43B0N@68525|delta/epsilon subdivisions,2X6EQ@28221|Deltaproteobacteria,2MICV@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Belongs to the HisA HisF family	-	-	5.3.1.16	ko:K01814	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04640	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
HKD2_k127_2249821_7	1121403.AUCV01000004_gene2013	2.74e-97	322.0	COG0467@1|root,COG0467@2|Bacteria,1R49F@1224|Proteobacteria,42P9V@68525|delta/epsilon subdivisions,2WPCD@28221|Deltaproteobacteria,2MIE8@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction	-	-	-	-	-	-	-	-	-	-	-	-	AAA_25
HKD2_k127_2249821_4	1121403.AUCV01000004_gene2012	4.381e-166	524.0	COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,42NDG@68525|delta/epsilon subdivisions,2WKYU@28221|Deltaproteobacteria,2MISU@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA1	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
HKD2_k127_2258203_1	589865.DaAHT2_0391	2.716e-72	263.0	COG3391@1|root,COG3391@2|Bacteria,1NW4P@1224|Proteobacteria,42Z3T@68525|delta/epsilon subdivisions	1224|Proteobacteria	S	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	NHL
HKD2_k127_2258203_0	589865.DaAHT2_0763	3.459e-74	264.0	COG3005@1|root,COG3005@2|Bacteria,1NYQE@1224|Proteobacteria,430WB@68525|delta/epsilon subdivisions,2WVN1@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Doubled CXXCH motif (Paired_CXXCH_1)	-	-	-	-	-	-	-	-	-	-	-	-	Paired_CXXCH_1
HKD2_k127_2258203_2	1123371.ATXH01000001_gene1285	4.655e-53	201.0	COG1729@1|root,COG1729@2|Bacteria	2|Bacteria	S	protein trimerization	slt	-	-	ko:K07114,ko:K08309	-	-	-	-	ko00000,ko01000,ko01011,ko02000	1.A.13.2.2,1.A.13.2.3	GH23	-	SLT,TPR_16,TPR_6
HKD2_k127_2258203_3	1121403.AUCV01000006_gene405	4.298e-39	147.0	COG0158@1|root,COG0158@2|Bacteria,1MW0E@1224|Proteobacteria,42NRA@68525|delta/epsilon subdivisions,2WJ62@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1	fbp	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005984,GO:0005985,GO:0005986,GO:0005996,GO:0006000,GO:0006002,GO:0006006,GO:0006094,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0019318,GO:0019319,GO:0019637,GO:0030388,GO:0034637,GO:0042132,GO:0042578,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0046364,GO:0050308,GO:0071704,GO:1901135,GO:1901576	3.1.3.11	ko:K03841	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko04152,ko04910,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map04152,map04910	M00003,M00165,M00167,M00344	R00762,R04780	RC00017	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	FBPase
HKD2_k127_2265456_2	1121405.dsmv_0756	1.079e-61	216.0	COG0411@1|root,COG0411@2|Bacteria,1MUTY@1224|Proteobacteria,42NMG@68525|delta/epsilon subdivisions,2WJ48@28221|Deltaproteobacteria,2MITM@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Branched-chain amino acid ATP-binding cassette transporter	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
HKD2_k127_2265456_0	1121405.dsmv_0755	7.626e-166	546.0	COG4177@1|root,COG4177@2|Bacteria,1MV66@1224|Proteobacteria,42M11@68525|delta/epsilon subdivisions,2WK66@28221|Deltaproteobacteria,2MI46@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HKD2_k127_2265456_1	1121403.AUCV01000002_gene643	1.034e-139	457.0	COG0559@1|root,COG0559@2|Bacteria,1MU25@1224|Proteobacteria,42NUE@68525|delta/epsilon subdivisions,2WJYH@28221|Deltaproteobacteria,2MI0A@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HKD2_k127_2265456_3	1121456.ATVA01000015_gene2383	1.252e-54	194.0	COG0683@1|root,COG0683@2|Bacteria,1MWJ1@1224|Proteobacteria,42PEN@68525|delta/epsilon subdivisions,2WJ9F@28221|Deltaproteobacteria,2M9B5@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	Extracellular ligand-binding receptor	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
HKD2_k127_2287074_2	1167006.UWK_03409	1.804e-29	120.0	COG0597@1|root,COG0597@2|Bacteria,1RGV9@1224|Proteobacteria,42UAT@68525|delta/epsilon subdivisions,2WQ31@28221|Deltaproteobacteria,2MK4S@213118|Desulfobacterales	28221|Deltaproteobacteria	MU	This protein specifically catalyzes the removal of signal peptides from prolipoproteins	lspA	-	3.4.23.36	ko:K03101	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_A8
HKD2_k127_2287074_0	1121403.AUCV01000008_gene1633	0.0	1373.0	COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,42MKB@68525|delta/epsilon subdivisions,2WJ4W@28221|Deltaproteobacteria,2MI4Z@213118|Desulfobacterales	28221|Deltaproteobacteria	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1,zf-FPG_IleRS
HKD2_k127_2287074_1	1167006.UWK_03252	7.703e-61	215.0	COG2109@1|root,COG2109@2|Bacteria,1MUN6@1224|Proteobacteria,42TG3@68525|delta/epsilon subdivisions,2WQIJ@28221|Deltaproteobacteria,2MPT6@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids	-	-	2.5.1.17	ko:K19221	ko00860,ko01100,map00860,map01100	M00122	R01492,R05220,R07268	RC00533	ko00000,ko00001,ko00002,ko01000	-	-	-	CobA_CobO_BtuR
HKD2_k127_2287074_3	1121403.AUCV01000008_gene1631	7.507e-14	79.0	COG0209@1|root,COG0209@2|Bacteria	2|Bacteria	F	ribonucleoside-diphosphate reductase activity	-	-	1.17.4.1	ko:K00525,ko:K00526	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	ATP-cone,Ribonuc_red_lgC,Ribonuc_red_lgN
HKD2_k127_2288576_2	243231.GSU1725	3.942e-163	525.0	COG0419@1|root,COG0419@2|Bacteria,1QKWB@1224|Proteobacteria,4377R@68525|delta/epsilon subdivisions,2WT00@28221|Deltaproteobacteria,43TVX@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	AAA domain	sbcC-2	-	-	ko:K03546	-	-	-	-	ko00000,ko03400	-	-	-	AAA_23
HKD2_k127_2288576_1	243231.GSU1724	2.742e-191	608.0	COG0420@1|root,COG0420@2|Bacteria,1PSRM@1224|Proteobacteria,42QIY@68525|delta/epsilon subdivisions,2WJNU@28221|Deltaproteobacteria,43S63@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	Calcineurin-like phosphoesterase	sbcD-2	-	-	ko:K03547	-	-	-	-	ko00000,ko03400	-	-	-	Metallophos
HKD2_k127_2288576_5	443144.GM21_2638	1.41e-78	267.0	COG0243@1|root,COG3383@1|root,COG0243@2|Bacteria,COG3383@2|Bacteria,1MW3N@1224|Proteobacteria,43BJY@68525|delta/epsilon subdivisions,2WIWD@28221|Deltaproteobacteria,43TK1@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Molybdopterin oxidoreductase Fe4S4 domain	fdnG-2	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding,TAT_signal
HKD2_k127_2288576_0	1123376.AUIU01000014_gene673	0.0	1264.0	COG0243@1|root,COG3383@1|root,COG0243@2|Bacteria,COG3383@2|Bacteria,3J0UR@40117|Nitrospirae	40117|Nitrospirae	C	Molydopterin dinucleotide binding domain	-	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
HKD2_k127_2288576_4	1121918.ARWE01000001_gene41	3.956e-94	314.0	COG0437@1|root,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,42R3B@68525|delta/epsilon subdivisions,2WN0N@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	-	-	-	ko:K00124	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001	-	-	-	Fer4_11
HKD2_k127_2288576_7	56780.SYN_00605	2.155e-33	137.0	COG2864@1|root,COG2864@2|Bacteria,1MXFQ@1224|Proteobacteria,42MVF@68525|delta/epsilon subdivisions,2WN3G@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Prokaryotic cytochrome b561	-	-	-	ko:K00127	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001	-	-	-	Ni_hydr_CYTB
HKD2_k127_2288576_6	289376.THEYE_A1305	3.582e-43	161.0	COG1651@1|root,COG1651@2|Bacteria,3J19Z@40117|Nitrospirae	40117|Nitrospirae	O	DSBA-like thioredoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2288576_3	289376.THEYE_A1303	4.977e-124	407.0	COG1858@1|root,COG1858@2|Bacteria,3J0GH@40117|Nitrospirae	40117|Nitrospirae	C	Di-haem cytochrome c peroxidase	-	-	1.11.1.5	ko:K00428	-	-	-	-	ko00000,ko01000	-	-	-	CCP_MauG,Cytochrom_C
HKD2_k127_2288576_8	289376.THEYE_A1302	1.267e-26	122.0	COG3058@1|root,COG3058@2|Bacteria	2|Bacteria	O	ferric iron binding	fdhE	GO:0003674,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006091,GO:0006807,GO:0008150,GO:0008152,GO:0008199,GO:0009061,GO:0009987,GO:0010467,GO:0015980,GO:0019538,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046872,GO:0046914,GO:0051604,GO:0055114,GO:0071704,GO:1901564	-	ko:K02380	-	-	-	-	ko00000	-	-	-	FdhE
HKD2_k127_2309731_0	929558.SMGD1_2206	3.486e-206	659.0	2EPTW@1|root,33HED@2|Bacteria,1NK6N@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2309731_3	357804.Ping_1732	1.272e-125	411.0	COG0598@1|root,COG0598@2|Bacteria,1MX09@1224|Proteobacteria,1T05M@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Magnesium transport protein CorA	corA	-	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
HKD2_k127_2309731_8	1121918.ARWE01000001_gene191	1.201e-39	151.0	COG0748@1|root,COG0748@2|Bacteria,1N2JV@1224|Proteobacteria,42TYW@68525|delta/epsilon subdivisions,2WQEM@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	PFAM pyridoxamine 5-phosphate	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
HKD2_k127_2309731_2	247490.KSU1_C0538	1.392e-144	464.0	COG1741@1|root,COG1741@2|Bacteria,2IXVU@203682|Planctomycetes	203682|Planctomycetes	S	Belongs to the pirin family	-	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin,Pirin_C
HKD2_k127_2309731_4	1167006.UWK_01462	3.527e-120	391.0	COG2084@1|root,COG2084@2|Bacteria,1PHRJ@1224|Proteobacteria,4348T@68525|delta/epsilon subdivisions,2X9TJ@28221|Deltaproteobacteria,2MNX7@213118|Desulfobacterales	28221|Deltaproteobacteria	I	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase	-	-	1.1.1.31	ko:K00020	ko00280,ko01100,map00280,map01100	-	R05066	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
HKD2_k127_2309731_1	589865.DaAHT2_2430	1.055e-154	499.0	COG1902@1|root,COG1902@2|Bacteria,1MVE0@1224|Proteobacteria,42NA7@68525|delta/epsilon subdivisions,2WIN5@28221|Deltaproteobacteria,2MJ30@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM NADH flavin oxidoreductase NADH oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_FMN
HKD2_k127_2309731_7	314345.SPV1_04338	1.29e-50	184.0	2DM91@1|root,327BS@2|Bacteria,1R3C3@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2309731_6	247490.KSU1_C1131	1.96e-72	248.0	COG1881@1|root,COG1881@2|Bacteria,2J1MM@203682|Planctomycetes	203682|Planctomycetes	G	Phosphatidylethanolamine-binding protein	-	-	-	ko:K06910	-	-	-	-	ko00000	-	-	-	PBP,YHYH
HKD2_k127_2309731_5	631362.Thi970DRAFT_01102	7.092e-78	272.0	2CFYY@1|root,3255I@2|Bacteria,1NVZK@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2329632_3	1049564.TevJSym_bf00090	1.487e-19	99.0	COG3437@1|root,COG3437@2|Bacteria,1MUB8@1224|Proteobacteria,1RPH3@1236|Gammaproteobacteria,1J4VQ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	T	a CheY-like receiver domain and an HD-GYP domain	rpfG	-	-	ko:K07814,ko:K13815	ko02020,ko02024,map02020,map02024	M00517	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HD,HD_5,Response_reg
HKD2_k127_2329632_0	1123392.AQWL01000009_gene1057	2.367e-191	604.0	COG1089@1|root,COG1089@2|Bacteria,1MUX0@1224|Proteobacteria,2VIBX@28216|Betaproteobacteria,1KSMX@119069|Hydrogenophilales	119069|Hydrogenophilales	M	GDP-mannose 4,6 dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	GDP_Man_Dehyd
HKD2_k127_2329632_2	395494.Galf_1274	5.108e-43	160.0	COG0399@1|root,COG0399@2|Bacteria,1N0QW@1224|Proteobacteria,2W39J@28216|Betaproteobacteria,44WJC@713636|Nitrosomonadales	28216|Betaproteobacteria	M	23S rRNA-intervening sequence protein	-	-	-	-	-	-	-	-	-	-	-	-	23S_rRNA_IVP
HKD2_k127_2329632_1	1485544.JQKP01000002_gene1481	5.838e-61	212.0	COG0451@1|root,COG0451@2|Bacteria,1MUGT@1224|Proteobacteria,2VK2N@28216|Betaproteobacteria,44VXT@713636|Nitrosomonadales	28216|Betaproteobacteria	GM	Catalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction	fcl	-	1.1.1.271	ko:K02377	ko00051,ko00520,ko01100,map00051,map00520,map01100	-	R05692	RC01014	ko00000,ko00001,ko01000	-	-	-	Epimerase
HKD2_k127_2341675_7	491952.Mar181_1241	2.735e-46	172.0	COG3672@1|root,COG3672@2|Bacteria,1RDQS@1224|Proteobacteria,1S3Y1@1236|Gammaproteobacteria,1XJ4Z@135619|Oceanospirillales	135619|Oceanospirillales	S	Bacterial transglutaminase-like cysteine proteinase BTLCP	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C93
HKD2_k127_2341675_3	316067.Geob_0567	5.194e-116	382.0	COG0500@1|root,COG0500@2|Bacteria,1QW86@1224|Proteobacteria,42N1Q@68525|delta/epsilon subdivisions,2WJJS@28221|Deltaproteobacteria,43TSG@69541|Desulfuromonadales	28221|Deltaproteobacteria	Q	Dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	Dimerisation2,Methyltransf_2
HKD2_k127_2341675_0	1121448.DGI_3104	1.967e-156	515.0	COG4907@1|root,COG4907@2|Bacteria,1MXPY@1224|Proteobacteria,42MA5@68525|delta/epsilon subdivisions,2WJGZ@28221|Deltaproteobacteria,2M9Y5@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Predicted membrane protein (DUF2207)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2207
HKD2_k127_2341675_6	525897.Dbac_2637	2.09e-60	216.0	COG1704@1|root,COG1704@2|Bacteria,1MVH0@1224|Proteobacteria,42S15@68525|delta/epsilon subdivisions,2WNI1@28221|Deltaproteobacteria,2MBH5@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	LemA family	-	-	-	ko:K03744	-	-	-	-	ko00000	-	-	-	LemA
HKD2_k127_2341675_5	316067.Geob_2236	1.938e-62	224.0	COG2191@1|root,COG2191@2|Bacteria,1RBNI@1224|Proteobacteria,42QZP@68525|delta/epsilon subdivisions,2WMY0@28221|Deltaproteobacteria,43VP7@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	FmdE, Molybdenum formylmethanofuran dehydrogenase operon	-	-	1.2.7.12	ko:K11261	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03015,R08060,R11743	RC00197,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	FmdE,zf-dskA_traR
HKD2_k127_2341675_11	644107.SL1157_0963	1.941e-08	61.0	COG0727@1|root,COG0727@2|Bacteria,1N5PC@1224|Proteobacteria,2UFEE@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Putative zinc- or iron-chelating domain	-	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
HKD2_k127_2341675_2	580332.Slit_0577	2.77e-116	383.0	COG0842@1|root,COG0842@2|Bacteria,1MVUG@1224|Proteobacteria,2VJWU@28216|Betaproteobacteria	28216|Betaproteobacteria	V	Transport permease protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
HKD2_k127_2341675_1	580332.Slit_0578	5.302e-117	383.0	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,2VI3G@28216|Betaproteobacteria,44VG9@713636|Nitrosomonadales	28216|Betaproteobacteria	V	PFAM ABC transporter related	-	-	-	ko:K01990,ko:K09695	ko02010,map02010	M00252,M00254	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.102	-	-	ABC_tran
HKD2_k127_2341675_10	933262.AXAM01000008_gene1966	9.449e-14	76.0	2CIGB@1|root,32TRQ@2|Bacteria,1N6CT@1224|Proteobacteria,42UF7@68525|delta/epsilon subdivisions,2WR4N@28221|Deltaproteobacteria,2MKHP@213118|Desulfobacterales	28221|Deltaproteobacteria	S	PilZ domain	-	-	-	-	-	-	-	-	-	-	-	-	PilZ
HKD2_k127_2341675_4	396588.Tgr7_1944	2.172e-90	301.0	COG1853@1|root,COG1853@2|Bacteria,1NB1B@1224|Proteobacteria,1S55P@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Flavin reductase	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
HKD2_k127_2341675_8	396588.Tgr7_1944	3.868e-33	133.0	COG1853@1|root,COG1853@2|Bacteria,1NB1B@1224|Proteobacteria,1S55P@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Flavin reductase	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
HKD2_k127_2341755_3	909663.KI867150_gene379	1.01e-36	145.0	COG0071@1|root,COG0071@2|Bacteria,1N7C7@1224|Proteobacteria,42U0T@68525|delta/epsilon subdivisions,2WQ7I@28221|Deltaproteobacteria,2MS9G@213462|Syntrophobacterales	28221|Deltaproteobacteria	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
HKD2_k127_2341755_4	1232410.KI421426_gene1514	7.899e-35	141.0	COG2020@1|root,COG2020@2|Bacteria,1RBJE@1224|Proteobacteria,42XPQ@68525|delta/epsilon subdivisions,2WT34@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	Phospholipid methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
HKD2_k127_2341755_0	1232410.KI421426_gene1513	2.717e-96	329.0	2C4IE@1|root,30ERP@2|Bacteria,1RG2Q@1224|Proteobacteria,42S4W@68525|delta/epsilon subdivisions,2WND7@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2341755_2	323261.Noc_2926	5.155e-43	166.0	COG0500@1|root,COG2226@2|Bacteria,1RB5H@1224|Proteobacteria,1SYTI@1236|Gammaproteobacteria,1X2IR@135613|Chromatiales	135613|Chromatiales	Q	Ribosomal protein L11 methyltransferase (PrmA)	-	-	2.1.1.103	ko:K05929	ko00564,map00564	-	R02037,R06868,R06869	RC00003,RC00060,RC00181,RC00496	ko00000,ko00001,ko01000	-	-	-	Methyltransf_25
HKD2_k127_2341755_1	1232410.KI421426_gene1512	1.015e-56	206.0	COG4591@1|root,COG4591@2|Bacteria,1R4Q2@1224|Proteobacteria,42N3Y@68525|delta/epsilon subdivisions,2WJFS@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HKD2_k127_2360312_5	404380.Gbem_1816	2.909e-131	430.0	COG0337@1|root,COG0337@2|Bacteria,1MUBK@1224|Proteobacteria,42MW5@68525|delta/epsilon subdivisions,2WK58@28221|Deltaproteobacteria,43W1D@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	3-dehydroquinate synthase	aroB	-	4.2.3.152,4.2.3.4	ko:K01735,ko:K19969	ko00400,ko00525,ko01100,ko01110,ko01130,ko01230,map00400,map00525,map01100,map01110,map01130,map01230	M00022,M00814,M00815	R03083,R10937	RC00847,RC03308	ko00000,ko00001,ko00002,ko01000	-	-	-	DHQ_synthase
HKD2_k127_2360312_4	589865.DaAHT2_1782	3.689e-140	484.0	COG5002@1|root,COG5278@1|root,COG5002@2|Bacteria,COG5278@2|Bacteria,1R5EN@1224|Proteobacteria,43D5Y@68525|delta/epsilon subdivisions,2X8CR@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
HKD2_k127_2360312_1	589865.DaAHT2_1780	1.632e-191	610.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2MIX8@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Sigma-54 interaction domain	-	-	-	ko:K07714,ko:K07715	ko02020,ko02024,map02020,map02024	M00500,M00502	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD2_k127_2360312_10	1121904.ARBP01000006_gene3681	2.774e-30	136.0	COG3419@1|root,COG4447@1|root,COG4932@1|root,COG5184@1|root,COG3419@2|Bacteria,COG4447@2|Bacteria,COG4932@2|Bacteria,COG5184@2|Bacteria,4NNEI@976|Bacteroidetes	976|Bacteroidetes	DZ	Putative metal-binding motif	-	-	-	-	-	-	-	-	-	-	-	-	Cu-binding_MopE,DUF1566
HKD2_k127_2360312_2	1131269.AQVV01000004_gene558	3.535e-175	579.0	COG4953@1|root,COG4953@2|Bacteria	2|Bacteria	M	penicillin binding	pbpC	-	2.4.1.129	ko:K05367	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	BiPBP_C,Transgly,Transpeptidase
HKD2_k127_2360312_0	1131269.AQVV01000004_gene557	1.467e-247	825.0	COG2373@1|root,COG2373@2|Bacteria	2|Bacteria	U	Large extracellular alpha-helical protein	-	-	-	ko:K06894	-	-	-	-	ko00000	-	-	-	A2M,A2M_N,A2M_N_2,Big_5,MG1,Thiol-ester_cl
HKD2_k127_2360312_8	1462526.BN990_02598	1.754e-81	283.0	COG1230@1|root,COG1230@2|Bacteria,1TR92@1239|Firmicutes,4HBCQ@91061|Bacilli,4C4KD@84406|Virgibacillus	91061|Bacilli	P	Cation efflux family	czcD	-	-	ko:K16264	-	-	-	-	ko00000,ko02000	2.A.4.1	-	-	Cation_efflux
HKD2_k127_2360312_3	580332.Slit_0125	2.631e-156	499.0	COG0667@1|root,COG0667@2|Bacteria,1MV2Y@1224|Proteobacteria,2VI7D@28216|Betaproteobacteria,44V9C@713636|Nitrosomonadales	28216|Betaproteobacteria	C	PFAM aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
HKD2_k127_2360312_7	891968.Anamo_1150	3.234e-88	295.0	COG0655@1|root,COG0655@2|Bacteria,3TBAN@508458|Synergistetes	508458|Synergistetes	S	NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
HKD2_k127_2360312_6	706587.Desti_1922	1.167e-93	317.0	COG0109@1|root,COG0109@2|Bacteria,1MW3S@1224|Proteobacteria,42UME@68525|delta/epsilon subdivisions,2WR3J@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group	ctaB	-	2.5.1.141	ko:K02257	ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714	M00154	R07411	RC01786	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029	-	-	-	UbiA
HKD2_k127_2360312_11	644968.DFW101_1569	1.456e-23	103.0	COG3125@1|root,COG3125@2|Bacteria,1RHE5@1224|Proteobacteria,43136@68525|delta/epsilon subdivisions,2WWGM@28221|Deltaproteobacteria,2MCRA@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	TIGRFAM Cytochrome o ubiquinol oxidase subunit IV	-	-	-	ko:K02300	ko00190,ko01100,map00190,map01100	M00417	-	-	ko00000,ko00001,ko00002	3.D.4.5	-	-	COX4_pro
HKD2_k127_2360312_12	706587.Desti_1924	3.085e-13	69.0	COG1845@1|root,COG1845@2|Bacteria,1MUCK@1224|Proteobacteria,42RCU@68525|delta/epsilon subdivisions,2WN7W@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	cytochrome c oxidase subunit III	-	-	1.9.3.1	ko:K02276,ko:K02299	ko00190,ko01100,map00190,map01100	M00155,M00417	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.4,3.D.4.5,3.D.4.6	-	-	COX3
HKD2_k127_2362911_0	880073.Calab_3450	6.541e-117	397.0	COG0587@1|root,COG0587@2|Bacteria,2NNVY@2323|unclassified Bacteria	2|Bacteria	L	DNA polymerase	dnaE-2	-	2.7.7.7	ko:K02337,ko:K14162	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP
HKD2_k127_237361_2	933262.AXAM01000017_gene3135	9.811e-33	128.0	COG1838@1|root,COG1951@1|root,COG1838@2|Bacteria,COG1951@2|Bacteria,1MUV9@1224|Proteobacteria,43DIW@68525|delta/epsilon subdivisions,2X8Q7@28221|Deltaproteobacteria,2MI8D@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Catalyzes the reversible hydration of fumarate to (S)- malate	fumB	-	4.2.1.2	ko:K01676	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumerase,Fumerase_C
HKD2_k127_237361_1	933262.AXAM01000017_gene3135	5.013e-213	667.0	COG1838@1|root,COG1951@1|root,COG1838@2|Bacteria,COG1951@2|Bacteria,1MUV9@1224|Proteobacteria,43DIW@68525|delta/epsilon subdivisions,2X8Q7@28221|Deltaproteobacteria,2MI8D@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Catalyzes the reversible hydration of fumarate to (S)- malate	fumB	-	4.2.1.2	ko:K01676	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumerase,Fumerase_C
HKD2_k127_237361_0	1121405.dsmv_1974	0.0	1620.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,1MVM0@1224|Proteobacteria,42MZ0@68525|delta/epsilon subdivisions,2WJ96@28221|Deltaproteobacteria,2MHRJ@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	poR	-	1.2.7.1	ko:K03737	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00173,M00307	R01196,R10866	RC00004,RC02742	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	EKR,Fer4_16,PFOR_II,POR,POR_N,TPP_enzyme_C
HKD2_k127_2390156_2	404380.Gbem_3593	1.585e-48	183.0	2ADWP@1|root,313NS@2|Bacteria,1N8BT@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2390156_0	234267.Acid_5309	4.522e-129	421.0	COG0686@1|root,COG0686@2|Bacteria,3Y3Y9@57723|Acidobacteria	57723|Acidobacteria	C	Belongs to the AlaDH PNT family	-	-	1.4.1.1	ko:K00259	ko00250,ko00430,ko01100,map00250,map00430,map01100	-	R00396	RC00008	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
HKD2_k127_2390156_3	1121403.AUCV01000008_gene1523	1.664e-34	138.0	COG1522@1|root,COG1522@2|Bacteria,1NC1H@1224|Proteobacteria,42XZS@68525|delta/epsilon subdivisions,2WSXJ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	Lrp/AsnC ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg
HKD2_k127_2390156_1	330214.NIDE2578	2.727e-53	200.0	2F9RH@1|root,3421I@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2427556_8	1121403.AUCV01000034_gene3844	8.089e-51	186.0	COG1968@1|root,COG1968@2|Bacteria,1MX02@1224|Proteobacteria,42N67@68525|delta/epsilon subdivisions,2WPKC@28221|Deltaproteobacteria,2MJE6@213118|Desulfobacterales	28221|Deltaproteobacteria	V	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin	uppP	-	3.6.1.27	ko:K06153	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	BacA
HKD2_k127_2427556_6	1167006.UWK_00432	5.28e-56	200.0	COG0526@1|root,COG0526@2|Bacteria,1N726@1224|Proteobacteria,42U61@68525|delta/epsilon subdivisions,2WQRF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	CO	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,Redoxin,Thioredoxin_8
HKD2_k127_2427556_5	1121403.AUCV01000001_gene929	4.906e-57	206.0	COG0746@1|root,COG0746@2|Bacteria	2|Bacteria	H	molybdenum cofactor guanylyltransferase activity	mobA	-	2.7.7.77,4.6.1.17	ko:K03637,ko:K03752,ko:K13818	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R11372,R11581	RC03425	ko00000,ko00001,ko01000	-	-	-	MobB,NTP_transf_3
HKD2_k127_2427556_2	1167006.UWK_02145	1.71e-96	330.0	COG2107@1|root,COG2107@2|Bacteria,1NYEA@1224|Proteobacteria,42MXB@68525|delta/epsilon subdivisions,2WIMS@28221|Deltaproteobacteria,2MJP9@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)	mqnD	-	-	ko:K11785	ko00130,ko01110,map00130,map01110	-	R08589	RC02330	ko00000,ko00001,ko01000	-	-	-	VitK2_biosynth
HKD2_k127_2427556_7	1121403.AUCV01000001_gene927	5.298e-55	200.0	COG0775@1|root,COG0775@2|Bacteria,1NDXU@1224|Proteobacteria,42TU4@68525|delta/epsilon subdivisions,2WQX3@28221|Deltaproteobacteria,2MK3J@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Catalyzes the hydrolysis of futalosine (FL) to dehypoxanthine futalosine (DHFL) and hypoxanthine, a step in the biosynthesis of menaquinone (MK, vitamin K2)	mqnB	-	3.2.2.26	ko:K11783	ko00130,ko01110,map00130,map01110	-	R08587	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	PNP_UDP_1
HKD2_k127_2427556_1	1121403.AUCV01000001_gene926	1.606e-123	406.0	COG0809@1|root,COG0809@2|Bacteria,1MUH3@1224|Proteobacteria,42MMG@68525|delta/epsilon subdivisions,2WJ9W@28221|Deltaproteobacteria,2MHXV@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)	queA	GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016853,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0051075,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.4.99.17	ko:K07568	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Queuosine_synth
HKD2_k127_2427556_10	1121439.dsat_2664	4.242e-34	134.0	COG0296@1|root,COG0296@2|Bacteria,1N8WX@1224|Proteobacteria,42VNQ@68525|delta/epsilon subdivisions,2WQ7J@28221|Deltaproteobacteria,2MC6I@213115|Desulfovibrionales	28221|Deltaproteobacteria	G	PFAM Glycoside hydrolase, family 13	-	-	-	-	-	-	-	-	-	-	-	-	AMPK1_CBM,CBM_48
HKD2_k127_2427556_11	1167006.UWK_02142	1.887e-25	108.0	COG2331@1|root,COG2331@2|Bacteria,1N6Q9@1224|Proteobacteria,42V24@68525|delta/epsilon subdivisions,2WR87@28221|Deltaproteobacteria,2MKWE@213118|Desulfobacterales	28221|Deltaproteobacteria	S	regulatory protein, FmdB family	-	-	-	-	-	-	-	-	-	-	-	-	Zn-ribbon_8
HKD2_k127_2427556_13	700598.Niako_4603	4.25e-06	60.0	COG3866@1|root,COG3866@2|Bacteria,4NH4E@976|Bacteroidetes,1J191@117747|Sphingobacteriia	976|Bacteroidetes	G	Amb_all	-	-	4.2.2.2	ko:K01728	ko00040,ko02024,map00040,map02024	-	R02361,R06240	RC00049,RC00705	ko00000,ko00001,ko01000	-	-	-	Pec_lyase_C
HKD2_k127_2427556_3	2045.KR76_06805	2.453e-85	312.0	COG4447@1|root,COG5492@1|root,COG4447@2|Bacteria,COG5492@2|Bacteria	2|Bacteria	N	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2427556_9	762903.Pedsa_2409	3.247e-47	194.0	COG2911@1|root,COG3210@1|root,COG4625@1|root,COG5492@1|root,COG2911@2|Bacteria,COG3210@2|Bacteria,COG4625@2|Bacteria,COG5492@2|Bacteria,4NHHA@976|Bacteroidetes	976|Bacteroidetes	E	domain protein	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Big_4,CHU_C,Calx-beta,He_PIG,NHL,TIG,fn3
HKD2_k127_2427556_0	335543.Sfum_2246	0.0	1564.0	COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,42NCZ@68525|delta/epsilon subdivisions,2WK3X@28221|Deltaproteobacteria,2MRHY@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K07787	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4	-	iAF987.Gmet_1547	ACR_tran
HKD2_k127_2427556_4	335543.Sfum_2247	1.171e-84	300.0	COG0845@1|root,COG3350@1|root,COG0845@2|Bacteria,COG3350@2|Bacteria,1MVAS@1224|Proteobacteria,42PKU@68525|delta/epsilon subdivisions,2WM5K@28221|Deltaproteobacteria,2MRTA@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K07798	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4,8.A.1	-	-	DUF3347,HlyD_D23
HKD2_k127_2431653_1	99598.Cal7507_3395	3.554e-114	385.0	COG1520@1|root,COG1520@2|Bacteria,1GHEB@1117|Cyanobacteria,1HKIG@1161|Nostocales	1117|Cyanobacteria	C	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	-	-	-	-	-	-	-	-	-	PPC
HKD2_k127_2431653_4	1121403.AUCV01000071_gene1280	8.956e-38	143.0	COG0776@1|root,COG0776@2|Bacteria,1MZ5B@1224|Proteobacteria,42VDU@68525|delta/epsilon subdivisions,2WRAI@28221|Deltaproteobacteria,2MPVM@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions	hupA	-	-	ko:K03530	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
HKD2_k127_2431653_3	1121403.AUCV01000071_gene1281	2.517e-66	239.0	COG1606@1|root,COG1606@2|Bacteria,1R7UZ@1224|Proteobacteria,42Q6V@68525|delta/epsilon subdivisions,2WKIM@28221|Deltaproteobacteria,2MJIS@213118|Desulfobacterales	28221|Deltaproteobacteria	S	PFAM asparagine synthase	-	-	-	ko:K06864	-	-	-	-	ko00000	-	-	-	Asn_synthase,NAD_synthase
HKD2_k127_2431653_0	1167006.UWK_02633	3.076e-193	617.0	COG1900@1|root,COG1900@2|Bacteria,1P1MT@1224|Proteobacteria,42M1I@68525|delta/epsilon subdivisions,2WIQ2@28221|Deltaproteobacteria,2MJ1R@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Homocysteine biosynthesis enzyme, sulfur-incorporation	-	-	-	-	-	-	-	-	-	-	-	-	HcyBio
HKD2_k127_2431653_2	177439.DP2171	2.901e-82	279.0	COG0077@1|root,COG1605@1|root,COG0077@2|Bacteria,COG1605@2|Bacteria,1MU60@1224|Proteobacteria,42MGN@68525|delta/epsilon subdivisions,2WJET@28221|Deltaproteobacteria,2MIFU@213118|Desulfobacterales	28221|Deltaproteobacteria	E	PFAM Prephenate dehydratase	pheA	-	4.2.1.51,5.4.99.5	ko:K14170	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024,M00025	R00691,R01373,R01715	RC00360,RC03116	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,CM_2,PDT
HKD2_k127_247194_3	1259795.ARJK01000002_gene409	8.843e-15	80.0	COG0834@1|root,COG0834@2|Bacteria,1TQUG@1239|Firmicutes,25C2V@186801|Clostridia,42J43@68295|Thermoanaerobacterales	186801|Clostridia	ET	Ligated ion channel L-glutamate- and glycine-binding site	glnH	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	SBP_bac_3
HKD2_k127_247194_1	1121403.AUCV01000017_gene4462	8.485e-65	227.0	COG2885@1|root,COG2885@2|Bacteria,1MZTV@1224|Proteobacteria,42R5H@68525|delta/epsilon subdivisions,2WNZS@28221|Deltaproteobacteria,2MJUT@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Belongs to the ompA family	pal	-	-	ko:K03640	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	OmpA
HKD2_k127_247194_0	1121403.AUCV01000017_gene4461	2.26e-70	244.0	COG0735@1|root,COG0735@2|Bacteria,1N0HW@1224|Proteobacteria,42TU6@68525|delta/epsilon subdivisions,2WPZ1@28221|Deltaproteobacteria,2MKMK@213118|Desulfobacterales	28221|Deltaproteobacteria	K	Belongs to the Fur family	-	-	-	ko:K03711,ko:K09825	-	-	-	-	ko00000,ko03000	-	-	-	FUR
HKD2_k127_247194_2	1379281.AVAG01000023_gene1915	8.576e-55	194.0	COG1592@1|root,COG1592@2|Bacteria,1R9WG@1224|Proteobacteria,42N9V@68525|delta/epsilon subdivisions,2WJWQ@28221|Deltaproteobacteria,2M9B4@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	PFAM Rubrerythrin	rbr	GO:0003674,GO:0005488,GO:0005506,GO:0043167,GO:0043169,GO:0046872,GO:0046914	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
HKD2_k127_2504638_2	314345.SPV1_00757	2.314e-24	104.0	COG4591@1|root,COG4591@2|Bacteria,1R4Q2@1224|Proteobacteria	1224|Proteobacteria	M	ABC-type transport system involved in lipoprotein release permease component	VPA0558	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HKD2_k127_2504638_0	314345.SPV1_00762	5.027e-82	280.0	COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria	1224|Proteobacteria	V	non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD2_k127_2512502_0	880072.Desac_1923	5.313e-118	380.0	COG2519@1|root,COG2519@2|Bacteria,1MXAK@1224|Proteobacteria,42NCI@68525|delta/epsilon subdivisions,2WJUH@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	Mycolic acid cyclopropane synthetase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
HKD2_k127_2512502_1	580332.Slit_2328	3.282e-107	349.0	COG0262@1|root,COG0262@2|Bacteria	2|Bacteria	H	dihydrofolate reductase activity	-	-	-	-	-	-	-	-	-	-	-	-	RibD_C
HKD2_k127_2512502_4	243233.MCA2780	2.47e-38	147.0	COG0666@1|root,COG0666@2|Bacteria	2|Bacteria	G	response to abiotic stimulus	-	GO:0003674,GO:0003779,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0006996,GO:0007010,GO:0007015,GO:0008092,GO:0008150,GO:0009987,GO:0016043,GO:0022607,GO:0030029,GO:0030036,GO:0042802,GO:0042803,GO:0043933,GO:0044085,GO:0044877,GO:0046983,GO:0051015,GO:0051259,GO:0065003,GO:0071840,GO:0097435	6.5.1.1	ko:K01971,ko:K03086,ko:K06867,ko:K06886	ko03450,map03450	-	R00381	RC00005	ko00000,ko00001,ko01000,ko03021,ko03400	-	-	-	Ank,Ank_2,Ank_4,Ank_5
HKD2_k127_2512502_3	1254432.SCE1572_28790	5.205e-67	236.0	2C3WA@1|root,2Z8P1@2|Bacteria,1R8VC@1224|Proteobacteria,43E08@68525|delta/epsilon subdivisions,2WZBV@28221|Deltaproteobacteria,2Z1SW@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2512502_2	933262.AXAM01000017_gene3113	1.225e-95	338.0	COG4206@1|root,COG4206@2|Bacteria,1MW63@1224|Proteobacteria,42PQU@68525|delta/epsilon subdivisions,2WM3U@28221|Deltaproteobacteria,2MMU8@213118|Desulfobacterales	28221|Deltaproteobacteria	H	TonB dependent receptor	-	-	-	ko:K16092	-	-	-	-	ko00000,ko02000	1.B.14.3	-	-	Plug,TonB_dep_Rec
HKD2_k127_251704_0	1167006.UWK_01341	3.272e-178	568.0	COG3259@1|root,COG3259@2|Bacteria,1QUQ7@1224|Proteobacteria,42N63@68525|delta/epsilon subdivisions,2WJPA@28221|Deltaproteobacteria,2MHPB@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM nickel-dependent hydrogenase large subunit	mvhL	-	1.12.1.2,1.8.98.5	ko:K00436,ko:K14126	ko00680,map00680	-	R00019,R00700,R11943	RC00011	ko00000,ko00001,ko01000	-	-	-	NiFeSe_Hases
HKD2_k127_251704_2	1167006.UWK_01340	2.068e-118	391.0	COG1941@1|root,COG1941@2|Bacteria,1NS0E@1224|Proteobacteria,42U69@68525|delta/epsilon subdivisions,2WQJZ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	NADH ubiquinone oxidoreductase 20 kDa subunit	hyhS	-	1.8.98.5	ko:K14128	ko00680,map00680	-	R00019,R11943	RC00011	ko00000,ko00001,ko01000	-	-	-	Oxidored_q6
HKD2_k127_251704_1	1167006.UWK_01339	1.337e-139	449.0	COG0543@1|root,COG0543@2|Bacteria,1R6QZ@1224|Proteobacteria,42MVW@68525|delta/epsilon subdivisions,2WKKC@28221|Deltaproteobacteria,2MJAK@213118|Desulfobacterales	28221|Deltaproteobacteria	CH	Oxidoreductase FAD-binding domain	hyhG	-	-	-	-	-	-	-	-	-	-	-	DHODB_Fe-S_bind,FAD_binding_6,NAD_binding_1
HKD2_k127_251704_3	1167006.UWK_01338	5.644e-73	248.0	COG1150@1|root,COG1150@2|Bacteria,1QWNB@1224|Proteobacteria,43BTA@68525|delta/epsilon subdivisions,2X741@28221|Deltaproteobacteria,2MI1V@213118|Desulfobacterales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_22
HKD2_k127_2519355_6	1121403.AUCV01000020_gene3114	6.754e-44	163.0	COG3635@1|root,COG3635@2|Bacteria,1R4TM@1224|Proteobacteria,43DQP@68525|delta/epsilon subdivisions,2X6VW@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	2,3-bisphosphoglycerate-independent phosphoglycerate mutase	-	-	5.4.2.12	ko:K15635	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,PhosphMutase
HKD2_k127_2519355_5	1121403.AUCV01000020_gene3113	2.674e-51	185.0	COG0824@1|root,COG0824@2|Bacteria,1PEBE@1224|Proteobacteria,42TIA@68525|delta/epsilon subdivisions,2WQ9X@28221|Deltaproteobacteria,2MMDF@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Thioesterase-like superfamily	-	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT,4HBT_2
HKD2_k127_2519355_7	768671.ThimaDRAFT_2415	2.05e-18	91.0	COG1708@1|root,COG1708@2|Bacteria,1NBM4@1224|Proteobacteria,1SCHR@1236|Gammaproteobacteria,1WZDS@135613|Chromatiales	135613|Chromatiales	S	DNA polymerase beta domain protein region	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_2
HKD2_k127_2519355_0	1158292.JPOE01000005_gene1179	6.259e-181	579.0	COG0038@1|root,COG0038@2|Bacteria,1MV4K@1224|Proteobacteria,2VGZT@28216|Betaproteobacteria	28216|Betaproteobacteria	P	chloride channel	clcB	-	-	ko:K03281	-	-	-	-	ko00000	2.A.49	-	-	CBS,Voltage_CLC
HKD2_k127_2519355_2	747365.Thena_1010	8.491e-135	452.0	COG0477@1|root,COG0477@2|Bacteria,1UNMW@1239|Firmicutes,25ECT@186801|Clostridia,42JGI@68295|Thermoanaerobacterales	186801|Clostridia	P	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
HKD2_k127_2519355_4	382464.ABSI01000007_gene4118	4.376e-87	293.0	COG0745@1|root,COG0745@2|Bacteria,46TFB@74201|Verrucomicrobia,2IUEX@203494|Verrucomicrobiae	203494|Verrucomicrobiae	T	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
HKD2_k127_2519355_3	402777.KB235903_gene1701	6.772e-91	320.0	COG0642@1|root,COG2205@2|Bacteria,1G06M@1117|Cyanobacteria,1H95E@1150|Oscillatoriales	1117|Cyanobacteria	T	Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
HKD2_k127_2519355_8	177437.HRM2_40870	6.331e-10	68.0	2EKF0@1|root,33E57@2|Bacteria,1NHTV@1224|Proteobacteria,42XCG@68525|delta/epsilon subdivisions,2WT8D@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2519355_10	338963.Pcar_0362	0.0003183	51.0	2EKF0@1|root,33E57@2|Bacteria,1NHTV@1224|Proteobacteria,42XCG@68525|delta/epsilon subdivisions,2WT8D@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2519355_1	1278307.KB907039_gene1114	4.038e-157	508.0	COG3678@1|root,COG3678@2|Bacteria	2|Bacteria	NPTU	ATP-independent chaperone mediated protein folding	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	HlyD_D23,LTXXQ
HKD2_k127_2519355_9	713587.THITH_11340	1.946e-07	61.0	28N9P@1|root,2ZBDN@2|Bacteria,1R70P@1224|Proteobacteria,1RQ5R@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function (DUF3592)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3592
HKD2_k127_2542144_1	243233.MCA2832	5.673e-84	288.0	COG2982@1|root,COG3164@1|root,COG2982@2|Bacteria,COG3164@2|Bacteria,1MUME@1224|Proteobacteria,1RNPC@1236|Gammaproteobacteria,1XE60@135618|Methylococcales	135618|Methylococcales	M	Domain of Unknown Function (DUF748)	-	-	-	-	-	-	-	-	-	-	-	-	DUF748
HKD2_k127_2542144_3	1232410.KI421420_gene3145	6.335e-27	117.0	COG0640@1|root,COG0640@2|Bacteria,1MZT1@1224|Proteobacteria,42VSP@68525|delta/epsilon subdivisions,2WRGT@28221|Deltaproteobacteria,43VD5@69541|Desulfuromonadales	28221|Deltaproteobacteria	K	PFAM regulatory protein, ArsR	-	-	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	HTH_5
HKD2_k127_2542144_0	1210884.HG799462_gene9129	2.248e-141	456.0	COG0798@1|root,COG0798@2|Bacteria,2IY8H@203682|Planctomycetes	203682|Planctomycetes	P	COG0798 Arsenite efflux pump ACR3 and related	-	-	-	ko:K03325	-	-	-	-	ko00000,ko02000	2.A.59	-	-	SBF
HKD2_k127_2542144_2	335543.Sfum_3600	1.063e-63	226.0	COG4871@1|root,COG4871@2|Bacteria,1RF0E@1224|Proteobacteria,42RKU@68525|delta/epsilon subdivisions,2WNHT@28221|Deltaproteobacteria,2MRPZ@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Putative Fe-S cluster	-	-	-	-	-	-	-	-	-	-	-	-	FeS
HKD2_k127_2542707_4	1232410.KI421424_gene1761	1.048e-61	229.0	2EXQK@1|root,33R03@2|Bacteria,1NQU4@1224|Proteobacteria,42Y7S@68525|delta/epsilon subdivisions,2WTT3@28221|Deltaproteobacteria,43UGY@69541|Desulfuromonadales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2542707_5	269799.Gmet_0325	3.133e-48	177.0	2EE9W@1|root,3384B@2|Bacteria,1NCE1@1224|Proteobacteria,42VUH@68525|delta/epsilon subdivisions,2WSA1@28221|Deltaproteobacteria,43V30@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Menaquinol oxidoreductase complex Cbc4, cytochrome c subunit	cbcS	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_c3_2,Cytochrome_C554,Paired_CXXCH_1
HKD2_k127_2542707_2	316067.Geob_1016	3.184e-124	402.0	COG0437@1|root,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,42QZ2@68525|delta/epsilon subdivisions,2WMS4@28221|Deltaproteobacteria,43T2N@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	cbcT	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_11,Fer4_2,Fer4_3,Fer4_7
HKD2_k127_2542707_1	1232410.KI421424_gene1755	2.58e-177	563.0	COG4881@1|root,COG4881@2|Bacteria,1QXMX@1224|Proteobacteria,43C41@68525|delta/epsilon subdivisions,2WKYD@28221|Deltaproteobacteria,43TBN@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Polysulphide reductase, NrfD	cbcU	-	-	-	-	-	-	-	-	-	-	-	NrfD
HKD2_k127_2542707_3	767817.Desgi_4249	1.049e-70	247.0	COG1456@1|root,COG1456@2|Bacteria,1VTSK@1239|Firmicutes,24XXV@186801|Clostridia,263UF@186807|Peptococcaceae	186801|Clostridia	C	CO dehydrogenase acetyl-CoA synthase gamma subunit (Corrinoid Fe-S protein)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3786,FeS
HKD2_k127_2542707_0	1121405.dsmv_1239	6.716e-227	720.0	COG1283@1|root,COG1283@2|Bacteria,1MUDE@1224|Proteobacteria,42PW9@68525|delta/epsilon subdivisions,2WJTI@28221|Deltaproteobacteria,2MJ12@213118|Desulfobacterales	28221|Deltaproteobacteria	P	PFAM Na Pi-cotransporter	-	-	-	ko:K03324	-	-	-	-	ko00000,ko02000	2.A.58.2	-	-	Na_Pi_cotrans
HKD2_k127_2542707_6	290315.Clim_0826	2.075e-42	158.0	COG1607@1|root,COG1607@2|Bacteria,1FEAZ@1090|Chlorobi	1090|Chlorobi	I	PFAM thioesterase superfamily protein	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
HKD2_k127_2542707_8	555778.Hneap_0011	8.739e-34	133.0	COG2852@1|root,COG2852@2|Bacteria,1N0QU@1224|Proteobacteria,1SAT7@1236|Gammaproteobacteria,1WZ6X@135613|Chromatiales	135613|Chromatiales	V	Protein of unknown function (DUF559)	-	-	2.1.1.72	ko:K03427	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	DUF559
HKD2_k127_2542707_7	316067.Geob_2992	3.278e-42	164.0	COG3123@1|root,COG3123@2|Bacteria,1MZ8N@1224|Proteobacteria,42TQH@68525|delta/epsilon subdivisions,2WQ2M@28221|Deltaproteobacteria,43V3M@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions	ppnP	-	2.4.2.1,2.4.2.2	ko:K09913	ko00230,ko00240,map00230,map00240	-	R01561,R01570,R01863,R01876,R02147,R02296,R02297	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	DUF1255
HKD2_k127_2542707_9	443144.GM21_3644	9.008e-07	53.0	2ADWP@1|root,313NS@2|Bacteria,1RHEN@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2553575_9	589865.DaAHT2_1951	2.122e-73	257.0	COG0477@1|root,COG2814@2|Bacteria,1MVSH@1224|Proteobacteria,42NA4@68525|delta/epsilon subdivisions,2WIJM@28221|Deltaproteobacteria	28221|Deltaproteobacteria	EGP	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD2_k127_2553575_17	1121445.ATUZ01000011_gene637	1.887e-28	117.0	COG0607@1|root,COG0607@2|Bacteria,1NBYS@1224|Proteobacteria,42VJA@68525|delta/epsilon subdivisions,2WS01@28221|Deltaproteobacteria,2MF95@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
HKD2_k127_2553575_14	243231.GSU1313	1.168e-48	179.0	COG0599@1|root,COG0599@2|Bacteria,1NBJR@1224|Proteobacteria,42SYS@68525|delta/epsilon subdivisions,2WPQD@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity	-	-	4.1.1.44	ko:K01607	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	-	R03470	RC00938	ko00000,ko00001,ko01000	-	-	-	CMD
HKD2_k127_2553575_6	1125863.JAFN01000001_gene2080	1.566e-110	367.0	COG0535@1|root,COG0535@2|Bacteria,1MU07@1224|Proteobacteria,42QKH@68525|delta/epsilon subdivisions,2WMW7@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM Radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF3641,Fer4_12,Radical_SAM
HKD2_k127_2553575_2	1121403.AUCV01000028_gene2456	3.453e-217	678.0	COG0436@1|root,COG0436@2|Bacteria,1MWS8@1224|Proteobacteria,42NH6@68525|delta/epsilon subdivisions,2WJCV@28221|Deltaproteobacteria,2MHTU@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate	dapL	GO:0003674,GO:0003824,GO:0008483,GO:0016740,GO:0016769	2.6.1.83	ko:K10206	ko00300,ko01100,ko01110,ko01130,ko01230,map00300,map01100,map01110,map01130,map01230	M00527	R07613	RC00006,RC01847	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
HKD2_k127_2553575_12	1121403.AUCV01000028_gene2457	9.794e-53	196.0	COG3117@1|root,COG3117@2|Bacteria	2|Bacteria	P	lipopolysaccharide transmembrane transporter activity	lptC	-	-	ko:K09774,ko:K11719	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	LptC
HKD2_k127_2553575_10	589865.DaAHT2_1325	2.766e-69	247.0	COG1778@1|root,COG1778@2|Bacteria,1RH85@1224|Proteobacteria,42SN2@68525|delta/epsilon subdivisions,2WP0X@28221|Deltaproteobacteria,2MPUR@213118|Desulfobacterales	28221|Deltaproteobacteria	S	haloacid dehalogenase-like hydrolase	kdsC	-	3.1.3.45	ko:K03270	ko00540,ko01100,map00540,map01100	M00063	R03350	RC00017	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hydrolase_3
HKD2_k127_2553575_5	1167006.UWK_00898	5.193e-123	399.0	COG2877@1|root,COG2877@2|Bacteria,1MV91@1224|Proteobacteria,42M61@68525|delta/epsilon subdivisions,2WIXU@28221|Deltaproteobacteria,2MHNJ@213118|Desulfobacterales	28221|Deltaproteobacteria	M	3-deoxy-D-manno-octulosonic acid 8-phosphate synthase	kdsA	-	2.5.1.55	ko:K01627	ko00540,ko01100,map00540,map01100	M00063	R03254	RC00435	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	DAHP_synth_1
HKD2_k127_2553575_1	1121403.AUCV01000028_gene2460	3.202e-294	912.0	COG0504@1|root,COG0504@2|Bacteria,1MUIT@1224|Proteobacteria,42MEU@68525|delta/epsilon subdivisions,2WJ0F@28221|Deltaproteobacteria,2MHTP@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_1276	CTP_synth_N,GATase
HKD2_k127_2553575_8	240015.ACP_0738	2.229e-81	281.0	COG3823@1|root,COG3823@2|Bacteria,3Y4G6@57723|Acidobacteria,2JMG7@204432|Acidobacteriia	204432|Acidobacteriia	M	Glutamine cyclotransferase	-	-	-	-	-	-	-	-	-	-	-	-	Glu_cyclase_2
HKD2_k127_2553575_16	1232410.KI421421_gene3619	2.201e-40	156.0	COG0500@1|root,COG0500@2|Bacteria,1RGJU@1224|Proteobacteria,42RZT@68525|delta/epsilon subdivisions,2WNDA@28221|Deltaproteobacteria,43V8H@69541|Desulfuromonadales	28221|Deltaproteobacteria	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31,Ubie_methyltran
HKD2_k127_2553575_7	1121033.AUCF01000008_gene5722	2.157e-106	365.0	29RC6@1|root,30CE8@2|Bacteria,1R3PV@1224|Proteobacteria,2TYW8@28211|Alphaproteobacteria,2JUY8@204441|Rhodospirillales	204441|Rhodospirillales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2553575_18	1530186.JQEY01000001_gene893	9.381e-07	53.0	COG1961@1|root,COG1961@2|Bacteria,1MWCZ@1224|Proteobacteria,2TRIY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Resolvase	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
HKD2_k127_2553575_4	717606.PaecuDRAFT_2755	3.555e-186	595.0	COG0114@1|root,COG0114@2|Bacteria,1UHPH@1239|Firmicutes,4HA6P@91061|Bacilli,2771G@186822|Paenibacillaceae	91061|Bacilli	C	Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate	fumC	GO:0003674,GO:0003824,GO:0004333,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006106,GO:0006108,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0055114,GO:0071704,GO:0072350	4.2.1.2	ko:K01679	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211	M00009,M00011,M00173,M00376	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	iSB619.SA_RS09430	FumaraseC_C,Lyase_1
HKD2_k127_2553575_13	96561.Dole_1521	2.428e-50	192.0	COG0642@1|root,COG2205@2|Bacteria	96561.Dole_1521|-	T	PhoQ Sensor	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2553575_0	1121403.AUCV01000015_gene4703	9.232e-307	950.0	COG0129@1|root,COG0129@2|Bacteria,1MUTQ@1224|Proteobacteria,42N3P@68525|delta/epsilon subdivisions,2WUCC@28221|Deltaproteobacteria,2MPYM@213118|Desulfobacterales	28221|Deltaproteobacteria	EG	Dehydratase family	-	-	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
HKD2_k127_2553575_3	1121403.AUCV01000015_gene4702	1.187e-198	625.0	COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,42M7F@68525|delta/epsilon subdivisions,2WJ4Z@28221|Deltaproteobacteria,2MHXJ@213118|Desulfobacterales	28221|Deltaproteobacteria	NU	PFAM type II secretion system protein E	pilT1	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
HKD2_k127_2553575_11	1121403.AUCV01000015_gene4701	6.722e-63	223.0	COG2204@1|root,COG2204@2|Bacteria,1R13N@1224|Proteobacteria,43D5X@68525|delta/epsilon subdivisions,2X8CQ@28221|Deltaproteobacteria,2MPN5@213118|Desulfobacterales	28221|Deltaproteobacteria	T	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2553575_15	1121403.AUCV01000015_gene4700	1.32e-41	156.0	COG0539@1|root,COG0539@2|Bacteria,1MVAV@1224|Proteobacteria,42M29@68525|delta/epsilon subdivisions,2WJ0X@28221|Deltaproteobacteria,2MI6Q@213118|Desulfobacterales	28221|Deltaproteobacteria	J	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence	rpsA	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
HKD2_k127_2559539_2	1304885.AUEY01000039_gene1521	3.921e-52	191.0	2C0RW@1|root,2ZBA6@2|Bacteria,1RJAD@1224|Proteobacteria,42SJV@68525|delta/epsilon subdivisions,2WP2Y@28221|Deltaproteobacteria,2MK50@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2559539_1	1283300.ATXB01000001_gene1159	1.638e-87	302.0	COG2102@1|root,COG2102@2|Bacteria,1MUU2@1224|Proteobacteria,1S3D2@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	ATPases of PP-loop superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Diphthami_syn_2
HKD2_k127_2559539_0	251229.Chro_2394	1.864e-134	440.0	COG0737@1|root,COG0737@2|Bacteria,1G262@1117|Cyanobacteria,3VKV4@52604|Pleurocapsales	1117|Cyanobacteria	F	5'-nucleotidase, C-terminal domain	-	-	3.1.3.5	ko:K01081	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	5_nucleotid_C,EF-hand_5,Metallophos
HKD2_k127_256512_1	323261.Noc_2530	3.15e-84	303.0	COG0741@1|root,COG0741@2|Bacteria,1MWRW@1224|Proteobacteria,1S084@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	lytic transglycosylase activity	-	-	-	-	-	-	-	-	-	-	-	-	SLT,SPOR
HKD2_k127_256512_0	1167006.UWK_00758	0.0	1161.0	COG1215@1|root,COG5309@1|root,COG1215@2|Bacteria,COG5309@2|Bacteria,1MX08@1224|Proteobacteria,42MS6@68525|delta/epsilon subdivisions,2WIYE@28221|Deltaproteobacteria,2MJNV@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Glycosyl transferase family 21	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3
HKD2_k127_2577398_4	765911.Thivi_2067	3.92e-44	163.0	COG1943@1|root,COG1943@2|Bacteria,1RCWW@1224|Proteobacteria,1S3ZJ@1236|Gammaproteobacteria,1WY9M@135613|Chromatiales	135613|Chromatiales	L	PFAM Transposase IS200 like	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
HKD2_k127_2577398_0	335543.Sfum_2149	0.0	1151.0	COG1148@1|root,COG1148@2|Bacteria,1QUM4@1224|Proteobacteria,42MPP@68525|delta/epsilon subdivisions,2WJ3U@28221|Deltaproteobacteria	2|Bacteria	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388,ko:K16885,ko:K16886	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_oxidored,Fer4,Fer4_20,Fer4_4,Fer4_7,FlpD,NAD_binding_8,Pyr_redox_2
HKD2_k127_2577398_3	1265505.ATUG01000003_gene614	2.879e-69	238.0	COG0247@1|root,COG0247@2|Bacteria,1N5Q2@1224|Proteobacteria,42P5D@68525|delta/epsilon subdivisions,2WJ9I@28221|Deltaproteobacteria,2MI9D@213118|Desulfobacterales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_17,Fer4_8
HKD2_k127_2577398_2	1121396.KB893051_gene3445	1.337e-76	264.0	COG0247@1|root,COG0247@2|Bacteria,1N5Q2@1224|Proteobacteria,42P5D@68525|delta/epsilon subdivisions,2WJ9I@28221|Deltaproteobacteria,2MI9D@213118|Desulfobacterales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_17,Fer4_8,Fer4_9
HKD2_k127_2577398_5	1249627.D779_1867	1.068e-10	71.0	2ATWF@1|root,31JFP@2|Bacteria,1RK55@1224|Proteobacteria,1S6Q1@1236|Gammaproteobacteria,1WYHR@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2577398_1	335543.Sfum_2943	5.877e-134	451.0	COG0784@1|root,COG2202@1|root,COG4191@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MC4@68525|delta/epsilon subdivisions,2WIZU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_4,PAS_9,Response_reg,dCache_1
HKD2_k127_2580114_5	1380387.JADM01000018_gene3365	4.162e-42	159.0	COG0791@1|root,COG0791@2|Bacteria,1N0EE@1224|Proteobacteria,1RR2X@1236|Gammaproteobacteria,1XKHX@135619|Oceanospirillales	135619|Oceanospirillales	M	COG0791 Cell wall-associated hydrolases (invasion-associated proteins)	-	-	3.4.17.13	ko:K13694,ko:K13695	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	NLPC_P60
HKD2_k127_2580114_4	1304885.AUEY01000004_gene925	3.333e-48	179.0	2BC31@1|root,325MS@2|Bacteria,1NBYV@1224|Proteobacteria,431MW@68525|delta/epsilon subdivisions,2WWTC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2580114_3	243231.GSU3155	2.91e-61	214.0	COG3005@1|root,COG3005@2|Bacteria,1PME8@1224|Proteobacteria,43A6A@68525|delta/epsilon subdivisions,2X2DB@28221|Deltaproteobacteria,43URH@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	NapC/NirT cytochrome c family, N-terminal region	-	-	-	ko:K15876	ko00910,ko01120,map00910,map01120	M00530	R05712	RC00176	ko00000,ko00001,ko00002	-	-	-	Cytochrom_NNT
HKD2_k127_2580114_0	269799.Gmet_0294	2.608e-249	777.0	COG3303@1|root,COG3303@2|Bacteria,1MVJT@1224|Proteobacteria,42MPU@68525|delta/epsilon subdivisions,2WIJ1@28221|Deltaproteobacteria,43TBA@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process	nrfA	-	1.7.2.2	ko:K03385	ko00910,ko01120,ko05132,map00910,map01120,map05132	M00530	R05712	RC00176	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytochrom_C552
HKD2_k127_2580114_6	1037409.BJ6T_63280	6.514e-11	75.0	2DBMS@1|root,2ZA09@2|Bacteria,1R5JC@1224|Proteobacteria,2U20F@28211|Alphaproteobacteria,3K6Z9@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2580114_1	1322246.BN4_10640	2.155e-192	614.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2M7UM@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	Two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	ko:K02481,ko:K07713	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD2_k127_2580114_2	1322246.BN4_10639	2.06e-96	324.0	COG3852@1|root,COG3852@2|Bacteria,1QUKH@1224|Proteobacteria,43BKB@68525|delta/epsilon subdivisions,2X6Y7@28221|Deltaproteobacteria,2MGVM@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	PFAM ATP-binding region ATPase domain protein	-	-	2.7.13.3	ko:K07709	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS_4,PAS_8,sCache_3_2
HKD2_k127_2592922_0	926569.ANT_25100	1.662e-179	576.0	COG3276@1|root,COG3276@2|Bacteria,2G5JX@200795|Chloroflexi	200795|Chloroflexi	J	Selenocysteine-specific translation elongation factor	selB	-	-	ko:K03833	-	-	-	-	ko00000,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,SelB-wing_2,SelB-wing_3
HKD2_k127_2598732_3	404380.Gbem_0272	2.44e-51	187.0	COG2770@1|root,COG4191@1|root,COG2770@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MC4@68525|delta/epsilon subdivisions,2WIZU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,Response_reg,dCache_1
HKD2_k127_2598732_2	1167006.UWK_02827	2.36e-73	251.0	COG0066@1|root,COG0066@2|Bacteria,1MVXB@1224|Proteobacteria,42R6H@68525|delta/epsilon subdivisions,2X5ND@28221|Deltaproteobacteria,2MK6S@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuD	-	4.2.1.33,4.2.1.35	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R10170	RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase_C
HKD2_k127_2598732_0	1167006.UWK_02828	7.091e-236	734.0	COG0065@1|root,COG0065@2|Bacteria,1MVYR@1224|Proteobacteria,42M5D@68525|delta/epsilon subdivisions,2WJ59@28221|Deltaproteobacteria,2MHP1@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuC	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
HKD2_k127_2598732_1	1167006.UWK_02829	1.549e-180	607.0	COG4166@1|root,COG4166@2|Bacteria,1MUVU@1224|Proteobacteria,42PKT@68525|delta/epsilon subdivisions,2WK85@28221|Deltaproteobacteria,2MPTE@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K13893	ko02010,map02010	M00349	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.21,3.A.1.5.24	-	-	SBP_bac_5
HKD2_k127_2610734_1	589865.DaAHT2_1931	9.26e-76	258.0	COG0773@1|root,COG0773@2|Bacteria,1MUC5@1224|Proteobacteria,42NMY@68525|delta/epsilon subdivisions,2WJ8S@28221|Deltaproteobacteria,2MHS5@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Belongs to the MurCDEF family	mpl	-	6.3.2.45	ko:K02558	-	-	-	-	ko00000,ko01000	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
HKD2_k127_2610734_3	1121403.AUCV01000007_gene1234	2.002e-18	89.0	COG2198@1|root,COG2198@2|Bacteria	2|Bacteria	T	Histidine kinase	evgS	GO:0000155,GO:0000160,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009268,GO:0009628,GO:0009927,GO:0009987,GO:0010447,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0035556,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0060089,GO:0065007,GO:0071704,GO:0140096,GO:1901564	2.7.13.3	ko:K02486,ko:K07677,ko:K07679	ko02020,ko02026,ko05133,map02020,map02026,map05133	M00474,M00477	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	7TMR-DISM_7TM,HATPase_c,HisKA,Hpt,Response_reg,SBP_bac_3
HKD2_k127_2610734_0	1121403.AUCV01000007_gene1235	3.433e-81	283.0	COG0037@1|root,COG0037@2|Bacteria,1MU85@1224|Proteobacteria,42NF0@68525|delta/epsilon subdivisions,2WIJK@28221|Deltaproteobacteria,2MHPA@213118|Desulfobacterales	28221|Deltaproteobacteria	D	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine	tilS	-	6.3.4.19	ko:K04075	-	-	R09597	RC02633,RC02634	ko00000,ko01000,ko03016	-	-	-	ATP_bind_3,TilS,TilS_C
HKD2_k127_2610734_4	1123368.AUIS01000015_gene2659	3.016e-10	65.0	2DG64@1|root,2ZUNW@2|Bacteria,1P9G9@1224|Proteobacteria	1224|Proteobacteria	S	Protein of unknown function (DUF1104)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1104
HKD2_k127_2610734_2	56780.SYN_01916	1.303e-37	143.0	COG0582@1|root,COG0582@2|Bacteria,1MU23@1224|Proteobacteria,42N7I@68525|delta/epsilon subdivisions,2WKY2@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Arm-DNA-bind_3,Phage_int_SAM_3,Phage_integrase
HKD2_k127_2615144_4	706587.Desti_0857	7.562e-06	48.0	2EFUW@1|root,339M2@2|Bacteria	2|Bacteria	S	Tripartite tricarboxylate transporter TctB family	-	-	-	ko:K07794	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctB
HKD2_k127_2615144_0	706587.Desti_0856	5.324e-221	696.0	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,42M32@68525|delta/epsilon subdivisions,2WJA4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Tripartite tricarboxylate transporter TctA family	-	-	-	ko:K07793	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctA
HKD2_k127_2615144_3	1031288.AXAA01000003_gene1611	2.969e-51	189.0	COG2185@1|root,COG2185@2|Bacteria,1V45Q@1239|Firmicutes,24HGC@186801|Clostridia,36IVB@31979|Clostridiaceae	186801|Clostridia	I	Catalyzes the carbon skeleton rearrangement of L- glutamate to L-threo-3-methylaspartate ((2S,3S)-3- methylaspartate)	mamA	-	5.4.99.1	ko:K01846	ko00630,ko00660,ko01100,ko01200,map00630,map00660,map01100,map01200	M00740	R00262	RC01221	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding
HKD2_k127_2615144_1	349161.Dred_2691	9.243e-147	478.0	COG0849@1|root,COG0849@2|Bacteria,1TQC5@1239|Firmicutes,24BFJ@186801|Clostridia,2605E@186807|Peptococcaceae	186801|Clostridia	D	TIGRFAM conserved	mutL2	-	-	-	-	-	-	-	-	-	-	-	MutL
HKD2_k127_2615144_2	1284708.HMPREF1634_04155	1.549e-51	186.0	COG4865@1|root,COG4865@2|Bacteria,1TS6B@1239|Firmicutes,24AYE@186801|Clostridia,3WD0D@538999|Clostridiales incertae sedis	186801|Clostridia	E	Catalyzes the carbon skeleton rearrangement of L- glutamate to L-threo-3-methylaspartate ((2S,3S)-3- methylaspartate)	glmE	-	5.4.99.1	ko:K19268	ko00630,ko00660,ko01100,ko01200,map00630,map00660,map01100,map01200	M00740	R00262	RC01221	ko00000,ko00001,ko00002,ko01000	-	-	-	Met_asp_mut_E
HKD2_k127_2617896_3	1121403.AUCV01000006_gene404	1.442e-45	173.0	COG0260@1|root,COG0260@2|Bacteria,1MUF9@1224|Proteobacteria,42M2G@68525|delta/epsilon subdivisions,2WJ80@28221|Deltaproteobacteria,2MIFW@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	pepA	-	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17,Peptidase_M17_N
HKD2_k127_2617896_1	1121403.AUCV01000006_gene403	7.889e-122	400.0	COG1253@1|root,COG1253@2|Bacteria,1MWT3@1224|Proteobacteria,42N45@68525|delta/epsilon subdivisions,2WKUD@28221|Deltaproteobacteria,2MHZA@213118|Desulfobacterales	28221|Deltaproteobacteria	S	CBS domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS,DUF21
HKD2_k127_2617896_2	96561.Dole_2417	2.032e-119	414.0	COG0457@1|root,COG1807@1|root,COG0457@2|Bacteria,COG1807@2|Bacteria,1NFQW@1224|Proteobacteria,42MT2@68525|delta/epsilon subdivisions,2WKWA@28221|Deltaproteobacteria,2MJFK@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Tetratricopeptide TPR_2 repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_11,TPR_16,TPR_2,TPR_4,TPR_8
HKD2_k127_2617896_0	1121403.AUCV01000006_gene401	2.732e-161	514.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,42NB6@68525|delta/epsilon subdivisions,2WIWE@28221|Deltaproteobacteria,2MN5K@213118|Desulfobacterales	28221|Deltaproteobacteria	O	PFAM peptidase S1 and S6 chymotrypsin Hap	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
HKD2_k127_2619615_1	1167006.UWK_01420	2.596e-134	434.0	COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,42M4Z@68525|delta/epsilon subdivisions,2WJZ3@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	-	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
HKD2_k127_2619615_0	909663.KI867150_gene268	1.037e-240	761.0	COG3158@1|root,COG3158@2|Bacteria,1MUVH@1224|Proteobacteria,42P5Y@68525|delta/epsilon subdivisions,2WJEH@28221|Deltaproteobacteria,2MQ9X@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	Transport of potassium into the cell	kup2	GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015672,GO:0016020,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0098655,GO:0098660,GO:0098662	-	ko:K03549	-	-	-	-	ko00000,ko02000	2.A.72	-	-	K_trans
HKD2_k127_2619615_2	697282.Mettu_3761	1.012e-100	348.0	COG1807@1|root,COG1807@2|Bacteria,1NMIZ@1224|Proteobacteria,1S48Z@1236|Gammaproteobacteria,1XEJQ@135618|Methylococcales	135618|Methylococcales	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HKD2_k127_2619615_5	697282.Mettu_3762	5.185e-37	141.0	COG3952@1|root,COG3952@2|Bacteria,1MZ60@1224|Proteobacteria,1S8XM@1236|Gammaproteobacteria,1XFI5@135618|Methylococcales	135618|Methylococcales	S	PFAM Lipid A Biosynthesis N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	LAB_N
HKD2_k127_2619615_4	243233.MCA0374	1.614e-76	263.0	COG0463@1|root,COG0463@2|Bacteria,1MW2G@1224|Proteobacteria,1S22P@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	COG0463 Glycosyltransferases involved in cell wall biogenesis	dpm1	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2
HKD2_k127_2619615_3	1121403.AUCV01000015_gene4714	1.172e-92	309.0	COG0745@1|root,COG0745@2|Bacteria,1N0YI@1224|Proteobacteria,43ADP@68525|delta/epsilon subdivisions,2WKI7@28221|Deltaproteobacteria,2MJ7M@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
HKD2_k127_2619615_6	1121403.AUCV01000016_gene4403	1.308e-14	78.0	COG3850@1|root,COG5002@1|root,COG3850@2|Bacteria,COG5002@2|Bacteria,1QTV1@1224|Proteobacteria,43BSP@68525|delta/epsilon subdivisions,2X7EK@28221|Deltaproteobacteria,2MPSB@213118|Desulfobacterales	28221|Deltaproteobacteria	T	GHKL domain	-	-	2.7.13.3	ko:K07642	ko02020,map02020	M00450,M00645,M00646,M00648	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
HKD2_k127_2641917_0	1254432.SCE1572_07790	4.03e-146	480.0	COG0348@1|root,COG1143@1|root,COG0348@2|Bacteria,COG1143@2|Bacteria,1MY5M@1224|Proteobacteria,43BPV@68525|delta/epsilon subdivisions,2WJVS@28221|Deltaproteobacteria,2YW51@29|Myxococcales	28221|Deltaproteobacteria	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_5,Fer4_7
HKD2_k127_2641917_1	56780.SYN_02059	2.083e-24	105.0	COG2006@1|root,COG2006@2|Bacteria,1QMGX@1224|Proteobacteria,42PRJ@68525|delta/epsilon subdivisions,2WMFN@28221|Deltaproteobacteria,2MQHV@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
HKD2_k127_2654385_1	1121403.AUCV01000050_gene2116	7.629e-175	564.0	COG1085@1|root,COG1085@2|Bacteria,1R6SM@1224|Proteobacteria,42QFF@68525|delta/epsilon subdivisions,2WKFN@28221|Deltaproteobacteria,2MIE7@213118|Desulfobacterales	28221|Deltaproteobacteria	C	galactose-1-phosphate uridylyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2654385_2	1121403.AUCV01000050_gene2115	3.282e-121	399.0	COG2905@1|root,COG2905@2|Bacteria	2|Bacteria	T	signal-transduction protein containing cAMP-binding and CBS domains	-	-	-	-	-	-	-	-	-	-	-	-	DUF4388,cNMP_binding
HKD2_k127_2654385_5	589865.DaAHT2_2196	7.346e-19	94.0	2E6WH@1|root,331G1@2|Bacteria,1NCI3@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2654385_3	1167006.UWK_01657	1.988e-94	320.0	COG1924@1|root,COG1924@2|Bacteria,1R6HU@1224|Proteobacteria,42PM0@68525|delta/epsilon subdivisions,2WJRP@28221|Deltaproteobacteria,2MHRM@213118|Desulfobacterales	28221|Deltaproteobacteria	I	PFAM BadF BadG BcrA BcrD ATPase family	-	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG
HKD2_k127_2654385_0	1167006.UWK_01656	8.759e-212	666.0	COG1775@1|root,COG1775@2|Bacteria,1NNW9@1224|Proteobacteria,42PEQ@68525|delta/epsilon subdivisions,2WKWX@28221|Deltaproteobacteria,2MHQR@213118|Desulfobacterales	28221|Deltaproteobacteria	E	PFAM 2-hydroxyglutaryl-CoA dehydratase, D-component	-	-	-	-	-	-	-	-	-	-	-	-	HGD-D
HKD2_k127_2654385_4	243231.GSU2516	1.868e-81	276.0	COG2897@1|root,COG2897@2|Bacteria,1MU3V@1224|Proteobacteria,42NRF@68525|delta/epsilon subdivisions,2WJZ6@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	PFAM Rhodanese domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
HKD2_k127_2667215_1	1121403.AUCV01000034_gene3853	2.706e-89	311.0	COG0760@1|root,COG0760@2|Bacteria,1MWV0@1224|Proteobacteria,42MPK@68525|delta/epsilon subdivisions,2WJM1@28221|Deltaproteobacteria,2MHM6@213118|Desulfobacterales	28221|Deltaproteobacteria	O	PFAM PpiC-type peptidyl-prolyl cis-trans isomerase	nifM	-	5.2.1.8	ko:K03770	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_2,Rotamase_3,SurA_N_3
HKD2_k127_2667215_0	1121403.AUCV01000034_gene3852	0.0	1097.0	COG0553@1|root,COG0553@2|Bacteria,1MV6M@1224|Proteobacteria,42M5P@68525|delta/epsilon subdivisions,2WIW8@28221|Deltaproteobacteria,2MIH9@213118|Desulfobacterales	28221|Deltaproteobacteria	L	SNF2 family N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Helicase_C,SNF2_N,SNF2_assoc
HKD2_k127_2683729_0	290318.Cvib_0980	3.201e-68	247.0	COG1092@1|root,COG1092@2|Bacteria,1FDS5@1090|Chlorobi	1090|Chlorobi	J	SMART PUA domain containing protein	-	-	2.1.1.191	ko:K06969	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_SAM
HKD2_k127_2687230_1	1121403.AUCV01000039_gene4371	8.677e-224	710.0	COG0077@1|root,COG0287@1|root,COG0077@2|Bacteria,COG0287@2|Bacteria,1MVUT@1224|Proteobacteria,42Q2P@68525|delta/epsilon subdivisions,2WMC9@28221|Deltaproteobacteria,2MJU2@213118|Desulfobacterales	28221|Deltaproteobacteria	E	prephenate dehydrogenase	tyrA	-	1.3.1.12,5.4.99.5	ko:K04517,ko:K14187	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	M00024,M00025	R01715,R01728	RC00125,RC03116	ko00000,ko00001,ko00002,ko01000	-	-	-	CM_2,PDH,PDT
HKD2_k127_2687230_0	1121403.AUCV01000039_gene4370	0.0	1092.0	COG1061@1|root,COG1205@1|root,COG1061@2|Bacteria,COG1205@2|Bacteria,1QU0I@1224|Proteobacteria,42M4R@68525|delta/epsilon subdivisions,2WK1V@28221|Deltaproteobacteria,2MI86@213118|Desulfobacterales	28221|Deltaproteobacteria	L	DEAD DEAH box helicase	yprA	-	-	ko:K06877	-	-	-	-	ko00000	-	-	-	DEAD,DUF1998,Helicase_C,RNase_H_2
HKD2_k127_2687230_2	1121403.AUCV01000039_gene4369	3.579e-26	109.0	COG3807@1|root,COG3807@2|Bacteria,1RIYJ@1224|Proteobacteria,42SNK@68525|delta/epsilon subdivisions,2WPNS@28221|Deltaproteobacteria,2MK8E@213118|Desulfobacterales	28221|Deltaproteobacteria	S	SH3 domain	-	-	-	-	-	-	-	-	-	-	-	-	SH3_4
HKD2_k127_2778773_4	589865.DaAHT2_2490	1.145e-09	64.0	COG1893@1|root,COG1893@2|Bacteria,1P0AW@1224|Proteobacteria,42QZK@68525|delta/epsilon subdivisions,2WPP6@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid	-	-	1.1.1.169	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R02472	RC00726	ko00000,ko00001,ko00002,ko01000	-	-	-	ApbA,ApbA_C
HKD2_k127_2778773_2	1167006.UWK_01831	6.043e-55	204.0	28PU4@1|root,2ZCF6@2|Bacteria,1N6FV@1224|Proteobacteria,43B3C@68525|delta/epsilon subdivisions,2X6H3@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2778773_3	1121403.AUCV01000005_gene248	2.158e-33	138.0	COG2755@1|root,COG2755@2|Bacteria,1NIYF@1224|Proteobacteria,42XYT@68525|delta/epsilon subdivisions,2WTHB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	lipolytic protein G-D-S-L family	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
HKD2_k127_2778773_0	1121403.AUCV01000005_gene249	2.407e-320	993.0	COG1523@1|root,COG1523@2|Bacteria,1MU19@1224|Proteobacteria,42P3J@68525|delta/epsilon subdivisions,2WKFS@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	Belongs to the glycosyl hydrolase 13 family	-	-	3.2.1.68	ko:K01214	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
HKD2_k127_2778773_1	1121403.AUCV01000005_gene250	5.949e-130	421.0	2AB4Z@1|root,310J3@2|Bacteria,1REKE@1224|Proteobacteria,42RRY@68525|delta/epsilon subdivisions,2WQFU@28221|Deltaproteobacteria,2MKTA@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF1566
HKD2_k127_2789307_7	439235.Dalk_0957	1.241e-62	226.0	COG2203@1|root,COG2804@1|root,COG2203@2|Bacteria,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,42P9Y@68525|delta/epsilon subdivisions,2WM6A@28221|Deltaproteobacteria,2MJCC@213118|Desulfobacterales	28221|Deltaproteobacteria	NTU	General secretory system II protein E domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,T2SSE,T2SSE_N
HKD2_k127_2789307_9	1167006.UWK_01655	2.829e-33	135.0	COG2005@1|root,COG2005@2|Bacteria,1MZ31@1224|Proteobacteria,42U1G@68525|delta/epsilon subdivisions,2WQEJ@28221|Deltaproteobacteria,2MKKW@213118|Desulfobacterales	28221|Deltaproteobacteria	K	PFAM Bacterial regulatory helix-turn-helix protein, lysR family	-	-	-	ko:K02019	-	-	-	-	ko00000,ko03000	-	-	-	HTH_1
HKD2_k127_2789307_8	1121403.AUCV01000020_gene3101	1.093e-45	186.0	COG0457@1|root,COG0457@2|Bacteria,1RIYN@1224|Proteobacteria,42T31@68525|delta/epsilon subdivisions,2WPYY@28221|Deltaproteobacteria,2MKKV@213118|Desulfobacterales	28221|Deltaproteobacteria	S	SGNH hydrolase-like domain, acetyltransferase AlgX	-	-	-	-	-	-	-	-	-	-	-	-	ALGX
HKD2_k127_2789307_0	1434929.X946_2903	2.127e-156	507.0	COG1696@1|root,COG1696@2|Bacteria,1MUXN@1224|Proteobacteria,2VISD@28216|Betaproteobacteria,1K5Z8@119060|Burkholderiaceae	28216|Betaproteobacteria	M	MBOAT, membrane-bound O-acyltransferase family	pacA	-	-	ko:K19294	-	-	-	-	ko00000	-	-	-	MBOAT
HKD2_k127_2789307_2	1121439.dsat_1396	6.526e-107	355.0	COG2998@1|root,COG2998@2|Bacteria,1MVSF@1224|Proteobacteria,42NK5@68525|delta/epsilon subdivisions,2WJ49@28221|Deltaproteobacteria,2M8YT@213115|Desulfovibrionales	28221|Deltaproteobacteria	H	PBP superfamily domain	tupA	-	-	ko:K05772	ko02010,map02010	M00186	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.2,3.A.1.6.4	-	-	PBP_like_2
HKD2_k127_2789307_3	1121405.dsmv_1069	6.988e-92	311.0	COG4662@1|root,COG4662@2|Bacteria,1MZVS@1224|Proteobacteria,42N6T@68525|delta/epsilon subdivisions,2WMKR@28221|Deltaproteobacteria,2MIW9@213118|Desulfobacterales	28221|Deltaproteobacteria	P	PFAM binding-protein-dependent transport systems inner membrane component	tupB	-	-	ko:K05773	ko02010,map02010	M00186	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.2,3.A.1.6.4	-	-	BPD_transp_1
HKD2_k127_2789307_4	177437.HRM2_17600	3.427e-76	267.0	COG3839@1|root,COG3839@2|Bacteria,1PA89@1224|Proteobacteria,42PEJ@68525|delta/epsilon subdivisions,2WJ1D@28221|Deltaproteobacteria,2MIHS@213118|Desulfobacterales	28221|Deltaproteobacteria	G	ABC transporter	-	-	3.6.3.55	ko:K06857	ko02010,map02010	M00186	R10531	RC00002	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.6.2,3.A.1.6.4	-	-	ABC_tran
HKD2_k127_2789307_12	909663.KI867150_gene1536	2.814e-06	55.0	COG2998@1|root,COG2998@2|Bacteria,1MVSF@1224|Proteobacteria,42NK5@68525|delta/epsilon subdivisions,2WM49@28221|Deltaproteobacteria,2MQA9@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	Bacterial extracellular solute-binding protein	-	-	-	ko:K05772	ko02010,map02010	M00186	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.2,3.A.1.6.4	-	-	PBP_like_2
HKD2_k127_2789307_11	545276.KB898743_gene2561	5.522e-27	128.0	COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1RMH0@1236|Gammaproteobacteria,1WWT2@135613|Chromatiales	135613|Chromatiales	NT	chemotaxis	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	HAMP,MCPsignal,dCache_3
HKD2_k127_2789307_5	335543.Sfum_2307	2.863e-67	256.0	COG3829@1|root,COG4191@1|root,COG3829@2|Bacteria,COG4191@2|Bacteria,1PFBE@1224|Proteobacteria,42YSB@68525|delta/epsilon subdivisions,2WU00@28221|Deltaproteobacteria,2MR36@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HisKA
HKD2_k127_2789307_1	767817.Desgi_4248	2.646e-131	436.0	COG3829@1|root,COG3829@2|Bacteria	2|Bacteria	T	transcription factor binding	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,PAS_4,PAS_9,Sigma54_activat
HKD2_k127_2789307_6	338969.Rfer_2740	2.735e-63	224.0	COG4117@1|root,COG4117@2|Bacteria,1R5GN@1224|Proteobacteria,2VP9C@28216|Betaproteobacteria	1224|Proteobacteria	C	cytochrome	cbcB	-	-	-	-	-	-	-	-	-	-	-	Ni_hydr_CYTB
HKD2_k127_2789307_10	289376.THEYE_A1058	4.367e-31	136.0	COG3005@1|root,COG3005@2|Bacteria	2|Bacteria	C	denitrification pathway	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_c3_2,Cytochrome_C554,Ni_hydr_CYTB,Paired_CXXCH_1
HKD2_k127_2815907_2	1121403.AUCV01000008_gene1610	1.683e-189	595.0	COG0451@1|root,COG0451@2|Bacteria,1MU7J@1224|Proteobacteria,42MWH@68525|delta/epsilon subdivisions,2WJMZ@28221|Deltaproteobacteria,2MI1B@213118|Desulfobacterales	28221|Deltaproteobacteria	M	PFAM NAD dependent epimerase dehydratase family	uge	-	5.1.3.6	ko:K08679	ko00520,ko01100,map00520,map01100	-	R01385	RC00289	ko00000,ko00001,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
HKD2_k127_2815907_0	1121403.AUCV01000008_gene1609	3.935e-204	646.0	COG0191@1|root,COG0191@2|Bacteria,1NMAK@1224|Proteobacteria,42NPW@68525|delta/epsilon subdivisions,2WIMN@28221|Deltaproteobacteria,2MHU7@213118|Desulfobacterales	28221|Deltaproteobacteria	G	aldolase class-II	-	-	4.1.2.13	ko:K01624	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167,M00344,M00345	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	F_bP_aldolase
HKD2_k127_2815907_6	177439.DP2718	3.758e-80	274.0	COG0805@1|root,COG0805@2|Bacteria,1MVAY@1224|Proteobacteria,42MM7@68525|delta/epsilon subdivisions,2WKJW@28221|Deltaproteobacteria,2MI7G@213118|Desulfobacterales	28221|Deltaproteobacteria	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides	tatC	-	-	ko:K03118	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	TatC
HKD2_k127_2815907_1	1121403.AUCV01000008_gene1607	2.883e-201	640.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2MI1N@213118|Desulfobacterales	28221|Deltaproteobacteria	T	sigma-54 factor interaction domain-containing protein	pilR	-	-	ko:K02667	ko02020,map02020	M00501	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD2_k127_2815907_5	1121403.AUCV01000008_gene1606	2.767e-149	490.0	COG3852@1|root,COG3852@2|Bacteria,1QVPN@1224|Proteobacteria,42PS3@68525|delta/epsilon subdivisions,2X7MQ@28221|Deltaproteobacteria,2MHPZ@213118|Desulfobacterales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	2.7.13.3	ko:K02668	ko02020,map02020	M00501	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	HATPase_c,HisKA,PAS,PAS_8
HKD2_k127_2815907_3	1121403.AUCV01000008_gene1595	4.7e-187	594.0	COG0766@1|root,COG0766@2|Bacteria,1MUH7@1224|Proteobacteria,42MJT@68525|delta/epsilon subdivisions,2WJ7W@28221|Deltaproteobacteria,2MHNI@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine	murA	-	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase
HKD2_k127_2815907_7	589865.DaAHT2_0609	5.767e-66	235.0	COG2890@1|root,COG2890@2|Bacteria,1MXCQ@1224|Proteobacteria,42PKA@68525|delta/epsilon subdivisions,2WNH0@28221|Deltaproteobacteria,2MHVH@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif	prmC	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0016740,GO:0016741,GO:0018364,GO:0019538,GO:0032259,GO:0036009,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0140096,GO:1901564	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS,Methyltransf_31
HKD2_k127_2815907_4	1121403.AUCV01000008_gene1593	2.943e-165	527.0	COG0216@1|root,COG0216@2|Bacteria,1MV28@1224|Proteobacteria,42NA3@68525|delta/epsilon subdivisions,2WIQU@28221|Deltaproteobacteria,2MHQM@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA	prfA	-	-	ko:K02835	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
HKD2_k127_2821107_2	1121403.AUCV01000001_gene938	8.02e-22	106.0	COG1216@1|root,COG1216@2|Bacteria,1MX5Z@1224|Proteobacteria,42QBQ@68525|delta/epsilon subdivisions,2WNMH@28221|Deltaproteobacteria,2MK4P@213118|Desulfobacterales	28221|Deltaproteobacteria	M	glycosyl transferase family 2	-	-	-	ko:K20444	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.1.3	GT2,GT4	-	Glyco_trans_1_2,Glycos_transf_2
HKD2_k127_2821107_0	1173024.KI912149_gene5486	9.736e-57	209.0	COG4122@1|root,COG4122@2|Bacteria,1GFDQ@1117|Cyanobacteria	1117|Cyanobacteria	S	Macrocin-O-methyltransferase (TylF)	-	-	-	-	-	-	-	-	-	-	-	-	TylF
HKD2_k127_2821107_1	1167006.UWK_02461	1.334e-50	182.0	COG1216@1|root,COG1216@2|Bacteria,1QX2S@1224|Proteobacteria,43BW7@68525|delta/epsilon subdivisions,2X76X@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HKD2_k127_28268_1	589865.DaAHT2_2152	6.702e-60	230.0	COG0784@1|root,COG4191@1|root,COG0784@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria	1224|Proteobacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K13587	ko02020,ko04112,map02020,map04112	M00512	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	GAF_2,HAMP,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_7,PAS_8,PAS_9,Response_reg,dCache_1
HKD2_k127_28268_0	1402135.SUH3_02490	1.865e-69	244.0	COG2304@1|root,COG2304@2|Bacteria,1PBVT@1224|Proteobacteria,2U3NK@28211|Alphaproteobacteria,3ZVJC@60136|Sulfitobacter	28211|Alphaproteobacteria	S	von Willebrand factor type A domain	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VWA,VWA_2
HKD2_k127_2829109_2	1121918.ARWE01000001_gene3120	5.087e-31	124.0	COG3946@1|root,COG3946@2|Bacteria,1R7R5@1224|Proteobacteria,42SDF@68525|delta/epsilon subdivisions,2WP3V@28221|Deltaproteobacteria	28221|Deltaproteobacteria	U	Bacterial virulence protein (VirJ)	-	-	-	-	-	-	-	-	-	-	-	-	VirJ
HKD2_k127_2829109_0	1121918.ARWE01000001_gene3106	1.096e-303	952.0	COG0392@1|root,COG2898@1|root,COG0392@2|Bacteria,COG2898@2|Bacteria,1MXH9@1224|Proteobacteria,42N7P@68525|delta/epsilon subdivisions,2WMCJ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Lysylphosphatidylglycerol synthase TM region	-	-	2.3.2.3	ko:K07027,ko:K14205	ko01503,ko02020,ko05150,map01503,map02020,map05150	M00726	-	-	ko00000,ko00001,ko00002,ko01000,ko01504,ko02000	2.A.1.3.37,4.D.2	-	-	DUF2156,LPG_synthase_TM
HKD2_k127_2829109_1	522772.Dacet_0904	1.766e-35	149.0	COG2984@1|root,COG2984@2|Bacteria	2|Bacteria	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
HKD2_k127_2838679_8	1167006.UWK_02363	3.388e-32	128.0	COG0859@1|root,COG0859@2|Bacteria,1MYZA@1224|Proteobacteria,43AFG@68525|delta/epsilon subdivisions,2WKA9@28221|Deltaproteobacteria,2MI8V@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Glycosyltransferase family 9 (heptosyltransferase)	-	-	-	ko:K02841	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9
HKD2_k127_2838679_6	1121403.AUCV01000001_gene962	1.455e-100	340.0	COG1215@1|root,COG1215@2|Bacteria,1R6YR@1224|Proteobacteria,43CDN@68525|delta/epsilon subdivisions,2WK5K@28221|Deltaproteobacteria,2MHYW@213118|Desulfobacterales	28221|Deltaproteobacteria	M	N-terminal domain of galactosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_7C,Glycos_transf_2
HKD2_k127_2838679_3	1121403.AUCV01000001_gene963	3.467e-130	426.0	COG0463@1|root,COG0463@2|Bacteria,1PVP4@1224|Proteobacteria,42M23@68525|delta/epsilon subdivisions,2WNU9@28221|Deltaproteobacteria,2MJ8C@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HKD2_k127_2838679_1	1121403.AUCV01000001_gene964	0.0	1072.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,42M51@68525|delta/epsilon subdivisions,2WIPP@28221|Deltaproteobacteria,2MI4H@213118|Desulfobacterales	28221|Deltaproteobacteria	NU	TIGRFAM type IV-A pilus assembly ATPase PilB	pilB	-	-	ko:K02652	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE,T2SSE_N,cNMP_binding
HKD2_k127_2838679_0	439235.Dalk_3639	0.0	1100.0	COG2759@1|root,COG2759@2|Bacteria,1MUR8@1224|Proteobacteria,42MKE@68525|delta/epsilon subdivisions,2WJF1@28221|Deltaproteobacteria,2MJ0Z@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Belongs to the formate--tetrahydrofolate ligase family	fhs	-	6.3.4.3	ko:K01938	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R00943	RC00026,RC00111	ko00000,ko00001,ko00002,ko01000	-	-	-	FTHFS
HKD2_k127_2838679_5	1499967.BAYZ01000033_gene1076	1.251e-107	365.0	COG0628@1|root,COG0628@2|Bacteria	2|Bacteria	D	permease	VP2476	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
HKD2_k127_2838679_4	1121403.AUCV01000001_gene965	1.264e-117	386.0	COG1351@1|root,COG1351@2|Bacteria,1R6TS@1224|Proteobacteria,43BGP@68525|delta/epsilon subdivisions,2WJ84@28221|Deltaproteobacteria,2MHVN@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant	thyX	-	2.1.1.148	ko:K03465	ko00240,ko00670,ko01100,map00240,map00670,map01100	-	R06613	RC00022,RC00332	ko00000,ko00001,ko01000	-	-	-	Thy1
HKD2_k127_2838679_2	1167006.UWK_02358	6.198e-216	683.0	COG1104@1|root,COG1104@2|Bacteria,1MU1C@1224|Proteobacteria,42M5V@68525|delta/epsilon subdivisions,2WIR6@28221|Deltaproteobacteria,2MHW4@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine	nifS-1	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
HKD2_k127_2838679_7	1167006.UWK_02357	2.866e-71	243.0	COG0694@1|root,COG0822@1|root,COG1251@1|root,COG0694@2|Bacteria,COG0822@2|Bacteria,COG1251@2|Bacteria,1RD5K@1224|Proteobacteria,42MT6@68525|delta/epsilon subdivisions,2WJBU@28221|Deltaproteobacteria,2MIAE@213118|Desulfobacterales	28221|Deltaproteobacteria	C	May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins	nifU	-	-	ko:K04488,ko:K13819	-	-	-	-	ko00000	-	-	-	Fer2_BFD,NifU,NifU_N
HKD2_k127_2844045_1	1304885.AUEY01000013_gene3126	5.504e-76	265.0	COG0589@1|root,COG0589@2|Bacteria,1QR0W@1224|Proteobacteria,42SGI@68525|delta/epsilon subdivisions,2WPQY@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD2_k127_2844045_0	1382306.JNIM01000001_gene1470	3.515e-94	312.0	COG1914@1|root,COG1914@2|Bacteria,2G67K@200795|Chloroflexi	200795|Chloroflexi	P	H( )-stimulated, divalent metal cation uptake system	mntH	-	-	ko:K03322	-	-	-	-	ko00000,ko02000	2.A.55.2.6,2.A.55.3	-	-	Nramp
HKD2_k127_2902337_1	1300345.LF41_1119	1.103e-69	241.0	COG0288@1|root,COG0288@2|Bacteria,1NGFN@1224|Proteobacteria,1S237@1236|Gammaproteobacteria,1X7P7@135614|Xanthomonadales	135614|Xanthomonadales	P	Reversible hydration of carbon dioxide	cynT1	-	4.2.1.1	ko:K01673	ko00910,map00910	-	R00132,R10092	RC02807	ko00000,ko00001,ko01000	-	-	-	Pro_CA
HKD2_k127_2902337_0	1454004.AW11_01979	2.551e-147	479.0	COG0628@1|root,COG0628@2|Bacteria,1MVX7@1224|Proteobacteria,2VJI5@28216|Betaproteobacteria	28216|Betaproteobacteria	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
HKD2_k127_2902337_2	312153.Pnuc_2048	8.882e-30	124.0	2E560@1|root,32ZYT@2|Bacteria,1N9G1@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2908025_6	713586.KB900536_gene100	2.388e-52	194.0	COG0742@1|root,COG0742@2|Bacteria,1MX8Z@1224|Proteobacteria,1RMIB@1236|Gammaproteobacteria,1WYUS@135613|Chromatiales	135613|Chromatiales	J	Specifically methylates the guanosine in position 1516 of 16S rRNA	rsmJ	-	2.1.1.242	ko:K15984	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SAM_MT
HKD2_k127_2908025_0	1121403.AUCV01000010_gene1357	3.5e-222	702.0	COG1578@1|root,COG1578@2|Bacteria,1R50K@1224|Proteobacteria,42Q0S@68525|delta/epsilon subdivisions,2WJ5M@28221|Deltaproteobacteria,2MIQ5@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Protein of unknown function DUF89	-	-	-	-	-	-	-	-	-	-	-	-	DUF89
HKD2_k127_2908025_1	1121403.AUCV01000010_gene1363	1.37e-199	627.0	COG0399@1|root,COG0399@2|Bacteria,1MUPN@1224|Proteobacteria,42MDC@68525|delta/epsilon subdivisions,2WJM7@28221|Deltaproteobacteria,2MHWR@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Belongs to the DegT DnrJ EryC1 family	-	-	2.6.1.102,2.6.1.109	ko:K13010,ko:K19715	ko00520,map00520	-	R10460,R11395	RC00006,RC00160,RC00781	ko00000,ko00001,ko01000,ko01005,ko01007	-	-	-	DegT_DnrJ_EryC1
HKD2_k127_2908025_7	1167006.UWK_02932	6.727e-42	157.0	COG0853@1|root,COG0853@2|Bacteria,1RI1B@1224|Proteobacteria,42SBM@68525|delta/epsilon subdivisions,2WQ24@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine	panD	-	4.1.1.11	ko:K01579	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R00489	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Asp_decarbox
HKD2_k127_2908025_4	243231.GSU1706	2.754e-88	299.0	COG0414@1|root,COG0414@2|Bacteria,1MV1S@1224|Proteobacteria,42N3J@68525|delta/epsilon subdivisions,2WJ19@28221|Deltaproteobacteria,43UFX@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate	panC	GO:0003674,GO:0003824,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006573,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605	6.3.2.1	ko:K01918	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R02473	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_ligase
HKD2_k127_2908025_9	1121403.AUCV01000010_gene1361	6.867e-36	145.0	COG2976@1|root,COG2976@2|Bacteria,1QVA2@1224|Proteobacteria,42S27@68525|delta/epsilon subdivisions,2X70J@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Tetratricopeptide repeat-like domain	-	-	-	-	-	-	-	-	-	-	-	-	TPR_21,TPR_6
HKD2_k127_2908025_3	1121403.AUCV01000010_gene1360	2.975e-132	436.0	COG1570@1|root,COG1570@2|Bacteria,1MUA4@1224|Proteobacteria,42MSB@68525|delta/epsilon subdivisions,2WJI6@28221|Deltaproteobacteria,2MHYI@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseA	-	3.1.11.6	ko:K03601	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_L,tRNA_anti_2
HKD2_k127_2908025_8	338963.Pcar_0485	1.026e-39	156.0	COG0368@1|root,COG0368@2|Bacteria,1RHCC@1224|Proteobacteria,42TXY@68525|delta/epsilon subdivisions,2WQ4J@28221|Deltaproteobacteria,43V8P@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate	cobS	-	2.7.8.26	ko:K02233	ko00860,ko01100,map00860,map01100	M00122	R05223,R11174	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	CobS
HKD2_k127_2908025_2	1167006.UWK_02956	3.671e-154	494.0	COG2038@1|root,COG2038@2|Bacteria,1MVAM@1224|Proteobacteria,42M3Z@68525|delta/epsilon subdivisions,2WJIR@28221|Deltaproteobacteria,2MI4Y@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB)	cobT	GO:0003674,GO:0003824,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008939,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0017144,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042364,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.4.2.21	ko:K00768	ko00860,ko01100,map00860,map01100	M00122	R04148	RC00033,RC00063	ko00000,ko00001,ko00002,ko01000	-	-	-	DBI_PRT
HKD2_k127_2908025_5	338963.Pcar_0487	3.412e-60	213.0	COG2087@1|root,COG2087@2|Bacteria,1RH0A@1224|Proteobacteria,42TMF@68525|delta/epsilon subdivisions,2WQNM@28221|Deltaproteobacteria,43VBA@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate	cobU	-	2.7.1.156,2.7.7.62	ko:K02231	ko00860,ko01100,map00860,map01100	M00122	R05221,R05222,R06558	RC00002,RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	CobU
HKD2_k127_2908025_10	1167006.UWK_02958	6.371e-34	140.0	COG0406@1|root,COG0406@2|Bacteria,1NPC4@1224|Proteobacteria,42SM1@68525|delta/epsilon subdivisions,2WP4T@28221|Deltaproteobacteria,2MKCV@213118|Desulfobacterales	1224|Proteobacteria	G	Phosphoglycerate mutase family	pgmA	-	3.1.3.73,3.1.3.85	ko:K02226,ko:K22306	ko00860,ko01100,map00860,map01100	M00122	R04594,R11173	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	His_Phos_1
HKD2_k127_2911464_3	1121456.ATVA01000018_gene381	7.471e-45	181.0	2AIHM@1|root,318ZH@2|Bacteria,1Q18U@1224|Proteobacteria,435X0@68525|delta/epsilon subdivisions,2X0DE@28221|Deltaproteobacteria,2MBWW@213115|Desulfovibrionales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2911464_0	1121403.AUCV01000014_gene4570	9.944e-144	468.0	COG0330@1|root,COG0330@2|Bacteria,1MUM2@1224|Proteobacteria,42NUT@68525|delta/epsilon subdivisions,2WKQX@28221|Deltaproteobacteria,2MI5I@213118|Desulfobacterales	28221|Deltaproteobacteria	O	HflC and HflK could encode or regulate a protease	hflK	-	-	ko:K04088	-	M00742	-	-	ko00000,ko00002,ko01000	-	-	-	Band_7
HKD2_k127_2911464_1	1121403.AUCV01000014_gene4571	2.594e-65	237.0	COG0705@1|root,COG0705@2|Bacteria,1N258@1224|Proteobacteria,42UB4@68525|delta/epsilon subdivisions,2WQJ3@28221|Deltaproteobacteria,2MKBC@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Rhomboid family	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
HKD2_k127_2911464_2	589865.DaAHT2_0098	2.248e-51	188.0	COG2271@1|root,COG2271@2|Bacteria,1QX38@1224|Proteobacteria,42NSX@68525|delta/epsilon subdivisions,2WK8G@28221|Deltaproteobacteria,2MJE8@213118|Desulfobacterales	28221|Deltaproteobacteria	G	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_4,Sugar_tr
HKD2_k127_291320_1	1173028.ANKO01000044_gene729	5.078e-33	129.0	COG1028@1|root,COG1028@2|Bacteria,1G4JP@1117|Cyanobacteria,1HBAW@1150|Oscillatoriales	1117|Cyanobacteria	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HKD2_k127_291320_0	926569.ANT_11990	2.773e-105	349.0	COG1921@1|root,COG1921@2|Bacteria,2G5VV@200795|Chloroflexi	200795|Chloroflexi	H	Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis	selA	-	2.9.1.1	ko:K01042	ko00450,ko00970,map00450,map00970	-	R08219	RC01246	ko00000,ko00001,ko01000	-	-	-	Se-cys_synth_N,SelA
HKD2_k127_2921747_5	1121403.AUCV01000025_gene2226	1.613e-48	183.0	COG1674@1|root,COG1674@2|Bacteria,1MVPI@1224|Proteobacteria,42N4X@68525|delta/epsilon subdivisions,2WIPR@28221|Deltaproteobacteria,2MI69@213118|Desulfobacterales	28221|Deltaproteobacteria	D	DNA segregation ATPase, FtsK SpoIIIE family	ftsK	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
HKD2_k127_2921747_6	1121403.AUCV01000025_gene2225	3.827e-46	172.0	COG0781@1|root,COG0781@2|Bacteria,1N94P@1224|Proteobacteria,42SEA@68525|delta/epsilon subdivisions,2WQP9@28221|Deltaproteobacteria,2MK59@213118|Desulfobacterales	28221|Deltaproteobacteria	K	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons	nusB	-	-	ko:K03625	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	NusB
HKD2_k127_2921747_3	1121403.AUCV01000025_gene2224	1.773e-76	258.0	COG0054@1|root,COG0054@2|Bacteria,1RD9J@1224|Proteobacteria,42RQ6@68525|delta/epsilon subdivisions,2WNCZ@28221|Deltaproteobacteria,2MJXP@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin	ribH	GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.78	ko:K00794	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R04457	RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	DMRL_synthase
HKD2_k127_2921747_0	1121403.AUCV01000025_gene2223	4.732e-217	681.0	COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,1MU8P@1224|Proteobacteria,42N1C@68525|delta/epsilon subdivisions,2WIP5@28221|Deltaproteobacteria,2MIF1@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate	ribBA	-	3.5.4.25,4.1.99.12	ko:K14652	ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110	M00125,M00840	R00425,R07281	RC00293,RC01792,RC01815,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	-	DHBP_synthase,GTP_cyclohydro2
HKD2_k127_2921747_2	1121403.AUCV01000025_gene2222	2.825e-88	295.0	COG0307@1|root,COG0307@2|Bacteria,1MUMB@1224|Proteobacteria,42QT1@68525|delta/epsilon subdivisions,2WNK6@28221|Deltaproteobacteria,2MJM4@213118|Desulfobacterales	28221|Deltaproteobacteria	H	TIGRFAM riboflavin synthase, alpha subunit	ribE	-	2.5.1.9	ko:K00793	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00066	RC00958,RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	Lum_binding
HKD2_k127_2921747_4	1121403.AUCV01000025_gene2221	8.542e-52	190.0	COG0457@1|root,COG0457@2|Bacteria	1121403.AUCV01000025_gene2221|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2921747_1	1121403.AUCV01000025_gene2220	2.56e-98	327.0	COG1413@1|root,COG1413@2|Bacteria,1P6NU@1224|Proteobacteria,4332R@68525|delta/epsilon subdivisions,2WXCP@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2938556_0	1283300.ATXB01000001_gene2242	3.319e-99	332.0	COG1073@1|root,COG1073@2|Bacteria,1RIWI@1224|Proteobacteria,1S6JM@1236|Gammaproteobacteria,1XE76@135618|Methylococcales	135618|Methylococcales	S	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4
HKD2_k127_2938556_3	1121448.DGI_0164	6.866e-24	106.0	2C46F@1|root,32SRD@2|Bacteria,1N540@1224|Proteobacteria,42UJ6@68525|delta/epsilon subdivisions,2WQUS@28221|Deltaproteobacteria,2MDCZ@213115|Desulfovibrionales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2938556_2	1265505.ATUG01000003_gene609	1.141e-32	136.0	COG4103@1|root,COG4103@2|Bacteria,1N6YZ@1224|Proteobacteria,42WGY@68525|delta/epsilon subdivisions,2WS4W@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Tellurite resistance protein TerB	-	-	-	-	-	-	-	-	-	-	-	-	TerB
HKD2_k127_2938556_1	589865.DaAHT2_1963	1.049e-48	189.0	COG2203@1|root,COG2204@1|root,COG4191@1|root,COG2203@2|Bacteria,COG2204@2|Bacteria,COG4191@2|Bacteria,1R13R@1224|Proteobacteria,43D5Z@68525|delta/epsilon subdivisions,2X8CS@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HATPase_c,HisKA,Response_reg
HKD2_k127_2947_7	335543.Sfum_0949	6.261e-29	129.0	COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,42PPF@68525|delta/epsilon subdivisions,2WM3K@28221|Deltaproteobacteria	28221|Deltaproteobacteria	Q	COG2931, RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2947_4	1121403.AUCV01000032_gene2904	2.994e-84	286.0	COG1596@1|root,COG1596@2|Bacteria	2|Bacteria	M	polysaccharide export	wza	-	-	ko:K01991,ko:K20988	ko02026,ko05111,map02026,map05111	-	-	-	ko00000,ko00001,ko02000	1.B.18	-	-	Poly_export,SLBB
HKD2_k127_2947_9	926562.Oweho_2161	2.478e-09	64.0	COG5295@1|root,COG5295@2|Bacteria,4NV9S@976|Bacteroidetes,1ICR8@117743|Flavobacteriia,2PBVB@246874|Cryomorphaceae	976|Bacteroidetes	UW	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2947_5	589865.DaAHT2_0821	1.393e-46	170.0	COG1908@1|root,COG1908@2|Bacteria,1RCZY@1224|Proteobacteria,42RJZ@68525|delta/epsilon subdivisions,2WND6@28221|Deltaproteobacteria,2MK4Q@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Methyl-viologen-reducing hydrogenase, delta subunit	-	-	1.8.98.5,1.8.98.6	ko:K14127	ko00680,map00680	-	R00019,R11943,R11944	RC00011	ko00000,ko00001,ko01000	-	-	-	FlpD
HKD2_k127_2947_6	589865.DaAHT2_0821	2.803e-37	140.0	COG1908@1|root,COG1908@2|Bacteria,1RCZY@1224|Proteobacteria,42RJZ@68525|delta/epsilon subdivisions,2WND6@28221|Deltaproteobacteria,2MK4Q@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Methyl-viologen-reducing hydrogenase, delta subunit	-	-	1.8.98.5,1.8.98.6	ko:K14127	ko00680,map00680	-	R00019,R11943,R11944	RC00011	ko00000,ko00001,ko01000	-	-	-	FlpD
HKD2_k127_2947_0	1167006.UWK_03157	0.0	1423.0	COG1148@1|root,COG1148@2|Bacteria,1QUM4@1224|Proteobacteria,42MPP@68525|delta/epsilon subdivisions,2WJ3U@28221|Deltaproteobacteria,2MIJ3@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM Pyridine nucleotide-disulphide oxidoreductase	bamE	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_7,NAD_binding_8,Pyr_redox_2
HKD2_k127_2947_8	1167006.UWK_03158	1.988e-24	103.0	COG1148@1|root,COG1148@2|Bacteria,1NA53@1224|Proteobacteria,42V92@68525|delta/epsilon subdivisions,2WS6E@28221|Deltaproteobacteria,2MM0X@213118|Desulfobacterales	28221|Deltaproteobacteria	C	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_8,Pyr_redox_2
HKD2_k127_2947_2	589865.DaAHT2_0823	1.458e-246	772.0	COG0493@1|root,COG3383@1|root,COG0493@2|Bacteria,COG3383@2|Bacteria,1MU2H@1224|Proteobacteria,43D5V@68525|delta/epsilon subdivisions,2X8CM@28221|Deltaproteobacteria,2MPN0@213118|Desulfobacterales	1224|Proteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	FeS,Fer2_4,Fer4,Fer4_20,Fer4_7,Fer4_9,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,Pyr_redox_2
HKD2_k127_2947_1	589865.DaAHT2_0823	0.0	1269.0	COG0493@1|root,COG3383@1|root,COG0493@2|Bacteria,COG3383@2|Bacteria,1MU2H@1224|Proteobacteria,43D5V@68525|delta/epsilon subdivisions,2X8CM@28221|Deltaproteobacteria,2MPN0@213118|Desulfobacterales	1224|Proteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	FeS,Fer2_4,Fer4,Fer4_20,Fer4_7,Fer4_9,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,Pyr_redox_2
HKD2_k127_2951204_2	706587.Desti_1925	1.236e-71	246.0	COG0843@1|root,COG0843@2|Bacteria,1MU7S@1224|Proteobacteria,42M18@68525|delta/epsilon subdivisions,2WJUK@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	coxA	-	1.10.3.10,1.9.3.1	ko:K02274,ko:K02298	ko00190,ko01100,map00190,map01100	M00155,M00417	R00081,R11335	RC00016,RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.5,3.D.4.6	-	-	COX1
HKD2_k127_2951204_0	596151.DesfrDRAFT_1678	1.432e-103	347.0	COG1622@1|root,COG1622@2|Bacteria,1MWHZ@1224|Proteobacteria,42M7N@68525|delta/epsilon subdivisions,2WM4F@28221|Deltaproteobacteria,2MAN1@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)	coxB	-	1.10.3.10,1.9.3.1	ko:K02275,ko:K02297	ko00190,ko01100,map00190,map01100	M00155,M00417	R00081,R11335	RC00016,RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.5,3.D.4.6	-	-	COX2,COX2_TM,COX_ARM,Cytochrom_C,Cytochrome_CBB3
HKD2_k127_2951204_1	269799.Gmet_1512	1.969e-86	296.0	COG0491@1|root,COG0491@2|Bacteria,1MX4H@1224|Proteobacteria,42PY0@68525|delta/epsilon subdivisions,2WJ2Y@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HKD2_k127_2951204_5	671143.DAMO_1960	8.783e-14	79.0	COG4314@1|root,COG4314@2|Bacteria	2|Bacteria	C	lipoprotein involved in nitrous oxide reduction	-	-	-	ko:K21601	-	-	-	-	ko00000,ko03000	-	-	-	HTH_DeoR,NosL
HKD2_k127_2951204_4	932678.THERU_04600	4.766e-16	84.0	COG1349@1|root,COG1349@2|Bacteria,2G501@200783|Aquificae	200783|Aquificae	K	Transcriptional regulator, DeoR family	-	-	-	ko:K21601	-	-	-	-	ko00000,ko03000	-	-	-	HTH_DeoR,NosL
HKD2_k127_2951204_3	717774.Marme_2492	1.794e-66	231.0	COG0288@1|root,COG0288@2|Bacteria,1NGFN@1224|Proteobacteria,1RSY6@1236|Gammaproteobacteria,1XJD9@135619|Oceanospirillales	135619|Oceanospirillales	P	Reversible hydration of carbon dioxide	yadF	-	4.2.1.1	ko:K01673	ko00910,map00910	-	R00132,R10092	RC02807	ko00000,ko00001,ko01000	-	-	-	Pro_CA
HKD2_k127_301444_0	766499.C357_23020	7.686e-99	341.0	COG0438@1|root,COG0438@2|Bacteria,1RBYC@1224|Proteobacteria,2U6QI@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
HKD2_k127_301444_2	702113.PP1Y_AT8050	1.094e-57	222.0	COG0500@1|root,COG2226@2|Bacteria,1RKCG@1224|Proteobacteria,2UA8V@28211|Alphaproteobacteria,2KA5C@204457|Sphingomonadales	204457|Sphingomonadales	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
HKD2_k127_301444_1	329726.AM1_2702	2.165e-98	342.0	COG0578@1|root,COG0578@2|Bacteria,1G1T3@1117|Cyanobacteria	1117|Cyanobacteria	C	Glycerol-3-phosphate dehydrogenase	-	-	1.1.5.3	ko:K00111	ko00564,ko01110,map00564,map01110	-	R00848	RC00029	ko00000,ko00001,ko01000	-	-	-	DAO,DAO_C
HKD2_k127_301444_4	203124.Tery_1676	5.413e-47	188.0	28KEP@1|root,2ZA0W@2|Bacteria,1G2EV@1117|Cyanobacteria,1H8V1@1150|Oscillatoriales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_301444_5	1167006.UWK_02474	5.736e-40	158.0	COG0110@1|root,COG0110@2|Bacteria	2|Bacteria	S	O-acyltransferase activity	-	-	2.3.1.79	ko:K00661	-	-	-	-	ko00000,ko01000	-	-	-	Hexapep,Hexapep_2
HKD2_k127_301444_3	1121468.AUBR01000005_gene69	2.138e-47	181.0	COG1035@1|root,COG1145@1|root,COG1035@2|Bacteria,COG1145@2|Bacteria,1TQGA@1239|Firmicutes,249BE@186801|Clostridia,42HGQ@68295|Thermoanaerobacterales	186801|Clostridia	C	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_7,FrhB_FdhB_C,FrhB_FdhB_N,PS_pyruv_trans
HKD2_k127_3021172_3	589865.DaAHT2_0404	1.341e-62	229.0	28WYN@1|root,33S49@2|Bacteria,1NRND@1224|Proteobacteria,42YS2@68525|delta/epsilon subdivisions,2WUFX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Paired_CXXCH_1
HKD2_k127_3021172_0	1232437.KL662036_gene2688	0.0	1477.0	28HYC@1|root,2Z83T@2|Bacteria,1QEBM@1224|Proteobacteria,42NM2@68525|delta/epsilon subdivisions,2WM1N@28221|Deltaproteobacteria,2MIIE@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3021172_4	861299.J421_0649	1.612e-58	216.0	COG0596@1|root,COG0596@2|Bacteria	861299.J421_0649|-	S	hydrolase activity, acting on ester bonds	-	-	3.4.11.5	ko:K01259	ko00330,map00330	-	R00135	-	ko00000,ko00001,ko01000,ko01002	-	-	-	-
HKD2_k127_3021172_1	357804.Ping_1553	5.236e-77	264.0	COG2095@1|root,COG2095@2|Bacteria,1MX5T@1224|Proteobacteria,1RPZ3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	U	UPF0056 membrane protein	-	-	-	ko:K05595	-	-	-	-	ko00000,ko02000	2.A.95.1	-	-	MarC
HKD2_k127_3021172_2	690850.Desaf_1667	8.964e-65	227.0	COG1032@1|root,COG1032@2|Bacteria,1MY2Y@1224|Proteobacteria,42NG3@68525|delta/epsilon subdivisions,2WJ95@28221|Deltaproteobacteria,2M84C@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,DUF4070,Radical_SAM
HKD2_k127_3032888_2	1121403.AUCV01000003_gene1771	3.808e-83	283.0	COG0787@1|root,COG0787@2|Bacteria,1MV0Q@1224|Proteobacteria,42MGU@68525|delta/epsilon subdivisions,2WIVG@28221|Deltaproteobacteria,2MHTA@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids	alr	-	5.1.1.1	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	-	R00401	RC00285	ko00000,ko00001,ko01000,ko01011	-	-	-	Ala_racemase_C,Ala_racemase_N
HKD2_k127_3032888_1	1121403.AUCV01000003_gene1772	4.957e-254	794.0	COG0018@1|root,COG0018@2|Bacteria,1MU4J@1224|Proteobacteria,42MTY@68525|delta/epsilon subdivisions,2WKII@28221|Deltaproteobacteria,2MI2W@213118|Desulfobacterales	28221|Deltaproteobacteria	J	TIGRFAM arginyl-tRNA synthetase	argS	GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	iAF987.Gmet_1434	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
HKD2_k127_3032888_3	589865.DaAHT2_1663	7.189e-62	216.0	COG1246@1|root,COG1246@2|Bacteria,1RHT7@1224|Proteobacteria,42SGE@68525|delta/epsilon subdivisions,2WP91@28221|Deltaproteobacteria,2MK41@213118|Desulfobacterales	28221|Deltaproteobacteria	E	PFAM GCN5-related N-acetyltransferase	argA	-	2.3.1.1	ko:K00619	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_0946	Acetyltransf_1,Acetyltransf_7
HKD2_k127_3032888_0	1121403.AUCV01000003_gene1775	0.0	1268.0	COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,42MMV@68525|delta/epsilon subdivisions,2WIZ4@28221|Deltaproteobacteria,2MIJD@213118|Desulfobacterales	28221|Deltaproteobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	Helicase_C,SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
HKD2_k127_3032888_4	1167006.UWK_02363	2.837e-60	213.0	COG0859@1|root,COG0859@2|Bacteria,1MYZA@1224|Proteobacteria,43AFG@68525|delta/epsilon subdivisions,2WKA9@28221|Deltaproteobacteria,2MI8V@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Glycosyltransferase family 9 (heptosyltransferase)	-	-	-	ko:K02841	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9
HKD2_k127_3054102_2	1121403.AUCV01000003_gene1791	1.05e-169	538.0	COG4174@1|root,COG4174@2|Bacteria,1MVKE@1224|Proteobacteria,43BKS@68525|delta/epsilon subdivisions,2X6YW@28221|Deltaproteobacteria,2MIBW@213118|Desulfobacterales	28221|Deltaproteobacteria	P	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K13894	ko02010,map02010	M00349	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.21,3.A.1.5.24	-	-	BPD_transp_1
HKD2_k127_3054102_1	1167006.UWK_02555	9.679e-172	546.0	COG4239@1|root,COG4239@2|Bacteria,1MUM5@1224|Proteobacteria,42P23@68525|delta/epsilon subdivisions,2WK75@28221|Deltaproteobacteria,2MIZ4@213118|Desulfobacterales	28221|Deltaproteobacteria	P	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K13895	ko02010,map02010	M00349	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.21,3.A.1.5.24	-	-	BPD_transp_1,OppC_N
HKD2_k127_3054102_5	1121403.AUCV01000003_gene1793	5.367e-91	327.0	2CFWZ@1|root,32ZKU@2|Bacteria,1NDUW@1224|Proteobacteria,42W37@68525|delta/epsilon subdivisions,2WRCI@28221|Deltaproteobacteria,2MKYY@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	ko:K08086	-	-	-	-	ko00000	-	-	-	-
HKD2_k127_3054102_4	1121403.AUCV01000003_gene1794	1.456e-112	366.0	COG1100@1|root,COG1100@2|Bacteria,1R6NS@1224|Proteobacteria,42NIX@68525|delta/epsilon subdivisions,2WJ44@28221|Deltaproteobacteria,2MI9K@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Gtr1/RagA G protein conserved region	mglA	GO:0008150,GO:0032879,GO:0032880,GO:0050789,GO:0065007	-	ko:K06883	-	-	-	-	ko00000	-	-	-	Arf,Ras
HKD2_k127_3054102_7	1121403.AUCV01000003_gene1795	2.613e-72	244.0	COG2018@1|root,COG2018@2|Bacteria,1RDN5@1224|Proteobacteria,42S13@68525|delta/epsilon subdivisions,2WNKB@28221|Deltaproteobacteria,2MKA4@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Roadblock/LC7 domain	mglB	-	-	-	-	-	-	-	-	-	-	-	Robl_LC7
HKD2_k127_3054102_9	335543.Sfum_1763	4.173e-34	141.0	2AB4Z@1|root,310J3@2|Bacteria,1N492@1224|Proteobacteria,42UZE@68525|delta/epsilon subdivisions,2X9RE@28221|Deltaproteobacteria,2MSAN@213462|Syntrophobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3054102_6	96561.Dole_2480	6.639e-73	253.0	COG2360@1|root,COG2360@2|Bacteria,1R9W8@1224|Proteobacteria,42QRC@68525|delta/epsilon subdivisions,2WMP7@28221|Deltaproteobacteria,2MHMA@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine	aat	-	2.3.2.6	ko:K00684	-	-	R03813,R11443,R11444	RC00055,RC00064	ko00000,ko01000	-	-	-	Leu_Phe_trans
HKD2_k127_3054102_0	589865.DaAHT2_0039	5.08e-185	592.0	COG0364@1|root,COG0364@2|Bacteria,1MUN0@1224|Proteobacteria,42M0J@68525|delta/epsilon subdivisions,2WK1D@28221|Deltaproteobacteria,2MMYN@213118|Desulfobacterales	28221|Deltaproteobacteria	G	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone	zwf	-	1.1.1.363,1.1.1.49	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	M00004,M00006,M00008	R00835,R02736,R10907	RC00001,RC00066	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	G6PD_C,G6PD_N
HKD2_k127_3054102_3	941449.dsx2_1835	1.737e-121	397.0	COG1023@1|root,COG1023@2|Bacteria,1QU14@1224|Proteobacteria,42MJI@68525|delta/epsilon subdivisions,2WJQP@28221|Deltaproteobacteria,2M88E@213115|Desulfovibrionales	28221|Deltaproteobacteria	G	PFAM 6-phosphogluconate dehydrogenase NAD-binding	gnd	-	1.1.1.343,1.1.1.44	ko:K00033	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200	M00004,M00006	R01528,R10221	RC00001,RC00539	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2620	6PGD,NAD_binding_2
HKD2_k127_3054102_8	1121403.AUCV01000020_gene3143	1.051e-55	213.0	COG3266@1|root,COG3267@1|root,COG3266@2|Bacteria,COG3267@2|Bacteria,1MU3G@1224|Proteobacteria	1224|Proteobacteria	U	Type II secretory pathway component ExeA	exeA1	-	-	ko:K12283	-	-	-	-	ko00000,ko02044	-	-	-	AAA_22,SPOR
HKD2_k127_3055839_2	1121918.ARWE01000001_gene402	4.213e-65	224.0	COG3260@1|root,COG3260@2|Bacteria,1QUBE@1224|Proteobacteria,42NH3@68525|delta/epsilon subdivisions,2WJX8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	NADH ubiquinone oxidoreductase 20 kDa subunit	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_q6
HKD2_k127_3055839_0	1121403.AUCV01000032_gene2878	1.222e-246	770.0	COG0034@1|root,COG0034@2|Bacteria,1MU0V@1224|Proteobacteria,42MDB@68525|delta/epsilon subdivisions,2WITV@28221|Deltaproteobacteria,2MI1E@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	-	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_6,GATase_7,Pribosyltran
HKD2_k127_3055839_4	1121403.AUCV01000032_gene2877	4.175e-14	73.0	COG1141@1|root,COG1141@2|Bacteria	2|Bacteria	C	electron transfer activity	-	-	-	ko:K05337	-	-	-	-	ko00000	-	-	-	Fer4_13,Fer4_15
HKD2_k127_3055839_1	1121403.AUCV01000032_gene2876	2.728e-99	335.0	COG1271@1|root,COG1271@2|Bacteria,1QXQF@1224|Proteobacteria,42NKJ@68525|delta/epsilon subdivisions,2WKHM@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Cytochrome c	-	-	-	ko:K08738	ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	3.D.4.6	-	-	-
HKD2_k127_3055839_3	1121403.AUCV01000032_gene2875	2.273e-43	165.0	COG1271@1|root,COG2010@1|root,COG1271@2|Bacteria,COG2010@2|Bacteria,1NTJT@1224|Proteobacteria,42NK8@68525|delta/epsilon subdivisions,2WIM0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM Cytochrome c, class I	-	-	-	-	-	-	-	-	-	-	-	-	Cyt_bd_oxida_I,Cytochrome_CBB3
HKD2_k127_3062098_4	580332.Slit_2907	6.814e-151	482.0	COG1088@1|root,COG1088@2|Bacteria,1MU5E@1224|Proteobacteria,2VJAD@28216|Betaproteobacteria,44V4M@713636|Nitrosomonadales	28216|Betaproteobacteria	M	Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily	rfbB	-	4.2.1.46	ko:K01710	ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130	M00793	R06513	RC00402	ko00000,ko00001,ko00002,ko01000	-	-	-	GDP_Man_Dehyd,dTDP_sugar_isom
HKD2_k127_3062098_13	338966.Ppro_2118	4.101e-82	279.0	COG1898@1|root,COG1898@2|Bacteria,1RDAB@1224|Proteobacteria,42SIT@68525|delta/epsilon subdivisions,2WP2W@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose	-	-	5.1.3.13	ko:K01790	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R06514	RC01531	ko00000,ko00001,ko00002,ko01000	-	-	-	dTDP_sugar_isom
HKD2_k127_3062098_2	1121403.AUCV01000035_gene3791	1.099e-200	634.0	COG1055@1|root,COG1055@2|Bacteria,1MUH8@1224|Proteobacteria,42KZP@68525|delta/epsilon subdivisions,2WKSV@28221|Deltaproteobacteria,2MHUQ@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Na H antiporter	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS,PAS
HKD2_k127_3062098_1	1121403.AUCV01000024_gene3401	2.126e-224	714.0	COG0557@1|root,COG0557@2|Bacteria,1MUS6@1224|Proteobacteria,42NHP@68525|delta/epsilon subdivisions,2X6U1@28221|Deltaproteobacteria,2MHMI@213118|Desulfobacterales	28221|Deltaproteobacteria	K	PFAM ribonuclease II	-	-	3.1.13.1	ko:K01147,ko:K12573	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	OB_RNB,RNB,S1
HKD2_k127_3062098_7	1121403.AUCV01000024_gene3399	6.29e-119	395.0	COG1159@1|root,COG1159@2|Bacteria,1MUKT@1224|Proteobacteria,42MUR@68525|delta/epsilon subdivisions,2WJC8@28221|Deltaproteobacteria,2MI0E@213118|Desulfobacterales	28221|Deltaproteobacteria	S	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism	era	-	-	ko:K03595	-	-	-	-	ko00000,ko03009,ko03029	-	-	-	KH_2,MMR_HSR1
HKD2_k127_3062098_5	1121403.AUCV01000024_gene3398	9.513e-146	475.0	COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,42MHD@68525|delta/epsilon subdivisions,2WJKC@28221|Deltaproteobacteria,2MJ79@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Belongs to the peptidase S41A family	ctpA	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_S41
HKD2_k127_3062098_15	1167006.UWK_03414	1.713e-71	262.0	COG4942@1|root,COG4942@2|Bacteria,1MY3E@1224|Proteobacteria,42N32@68525|delta/epsilon subdivisions,2WKBN@28221|Deltaproteobacteria,2MI0S@213118|Desulfobacterales	28221|Deltaproteobacteria	D	PFAM peptidase	-	-	-	ko:K21471	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_M23,SH3_3
HKD2_k127_3062098_8	1121403.AUCV01000024_gene3396	4.192e-115	377.0	COG2177@1|root,COG2177@2|Bacteria,1MU65@1224|Proteobacteria,43BBA@68525|delta/epsilon subdivisions,2X6QG@28221|Deltaproteobacteria,2MPIA@213118|Desulfobacterales	28221|Deltaproteobacteria	D	Part of the ABC transporter FtsEX involved in cellular division	ftsX	-	-	ko:K09811	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	FtsX
HKD2_k127_3062098_14	1121403.AUCV01000024_gene3395	6.323e-81	279.0	COG2884@1|root,COG2884@2|Bacteria,1MVQ4@1224|Proteobacteria,42MAM@68525|delta/epsilon subdivisions,2WK4Y@28221|Deltaproteobacteria,2MJCE@213118|Desulfobacterales	28221|Deltaproteobacteria	D	PFAM ABC transporter	ftsE	-	-	ko:K09812	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	ABC_tran
HKD2_k127_3062098_9	1167006.UWK_03411	1.777e-112	368.0	COG3640@1|root,COG3640@2|Bacteria,1R819@1224|Proteobacteria,42PQR@68525|delta/epsilon subdivisions,2WKE4@28221|Deltaproteobacteria,2MIKC@213118|Desulfobacterales	28221|Deltaproteobacteria	D	PFAM Cobyrinic acid ac-diamide synthase	-	-	-	ko:K07321	-	-	-	-	ko00000	-	-	-	CbiA
HKD2_k127_3062098_16	247490.KSU1_B0710	2.165e-69	242.0	COG0546@1|root,COG0546@2|Bacteria,2J0GC@203682|Planctomycetes	203682|Planctomycetes	S	haloacid dehalogenase-like hydrolase	-	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
HKD2_k127_3062098_10	1167006.UWK_03263	1.158e-110	379.0	COG4399@1|root,COG4399@2|Bacteria,1R42C@1224|Proteobacteria,42Q2W@68525|delta/epsilon subdivisions,2WJIA@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Protein of unknown function (DUF445)	-	-	-	-	-	-	-	-	-	-	-	-	DUF445
HKD2_k127_3062098_19	1121403.AUCV01000023_gene3382	0.0004492	51.0	COG1196@1|root,COG1196@2|Bacteria	2|Bacteria	D	nuclear chromosome segregation	CP_0769	-	-	-	-	-	-	-	-	-	-	-	DUF1978,Guanylate_cyc,HAMP,IncA
HKD2_k127_3062098_0	1121403.AUCV01000023_gene3381	0.0	1035.0	COG0296@1|root,COG0296@2|Bacteria,1MVM7@1224|Proteobacteria,43AEI@68525|delta/epsilon subdivisions,2X5UC@28221|Deltaproteobacteria,2MPH6@213118|Desulfobacterales	28221|Deltaproteobacteria	G	Alpha amylase, C-terminal all-beta domain	-	-	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48
HKD2_k127_3062098_3	1167006.UWK_02626	8.837e-163	523.0	COG1979@1|root,COG1979@2|Bacteria,1QUBJ@1224|Proteobacteria,42MPI@68525|delta/epsilon subdivisions,2WJGY@28221|Deltaproteobacteria,2MMPE@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Iron-containing alcohol dehydrogenase	-	-	1.1.1.1	ko:K00001,ko:K08325	ko00010,ko00071,ko00350,ko00625,ko00626,ko00640,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00640,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R02528,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC00739,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	Fe-ADH
HKD2_k127_3062098_11	1121403.AUCV01000071_gene1292	1.605e-92	321.0	COG0030@1|root,COG0030@2|Bacteria,1MVNU@1224|Proteobacteria,42QAC@68525|delta/epsilon subdivisions,2WN8H@28221|Deltaproteobacteria,2MIAF@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
HKD2_k127_3062098_17	1121403.AUCV01000071_gene1293	7.588e-41	157.0	COG3216@1|root,COG3216@2|Bacteria,1QEG2@1224|Proteobacteria,42VUY@68525|delta/epsilon subdivisions,2WRD1@28221|Deltaproteobacteria,2MM28@213118|Desulfobacterales	28221|Deltaproteobacteria	S	protein conserved in bacteria (DUF2062)	-	-	-	ko:K09928	-	-	-	-	ko00000	-	-	-	DUF2062
HKD2_k127_3062098_6	1121403.AUCV01000071_gene1291	8.577e-133	430.0	COG0533@1|root,COG0533@2|Bacteria,1MU6S@1224|Proteobacteria,42MHX@68525|delta/epsilon subdivisions,2WIKS@28221|Deltaproteobacteria,2MI6H@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction	tsaD	GO:0000408,GO:0002949,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
HKD2_k127_3062098_12	1121403.AUCV01000071_gene1282	2.935e-86	287.0	COG0077@1|root,COG1605@1|root,COG0077@2|Bacteria,COG1605@2|Bacteria,1MU60@1224|Proteobacteria,42MGN@68525|delta/epsilon subdivisions,2WJET@28221|Deltaproteobacteria,2MIFU@213118|Desulfobacterales	28221|Deltaproteobacteria	E	PFAM Prephenate dehydratase	pheA	-	4.2.1.51,5.4.99.5	ko:K14170	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024,M00025	R00691,R01373,R01715	RC00360,RC03116	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,CM_2,PDT
HKD2_k127_3072299_1	404380.Gbem_0478	6.157e-08	55.0	COG0327@1|root,COG0327@2|Bacteria,1R34P@1224|Proteobacteria,42P4V@68525|delta/epsilon subdivisions,2X6FS@28221|Deltaproteobacteria,43U23@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Belongs to the GTP cyclohydrolase I type 2 NIF3 family	yqfO	-	-	-	-	-	-	-	-	-	-	-	NIF3
HKD2_k127_3072299_2	509191.AEDB02000003_gene1019	1.094e-05	49.0	2DPV4@1|root,333HA@2|Bacteria,1VH7Z@1239|Firmicutes,24SC2@186801|Clostridia,3WQ8C@541000|Ruminococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3072299_0	1121403.AUCV01000032_gene2886	2.474e-173	565.0	COG0501@1|root,COG3063@1|root,COG0501@2|Bacteria,COG3063@2|Bacteria,1R5A7@1224|Proteobacteria,42MP6@68525|delta/epsilon subdivisions,2WK92@28221|Deltaproteobacteria,2MIHI@213118|Desulfobacterales	28221|Deltaproteobacteria	O	PFAM peptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48,TPR_11,TPR_17
HKD2_k127_3079277_2	314345.SPV1_00747	5.023e-81	278.0	COG2834@1|root,COG2834@2|Bacteria,1R5U8@1224|Proteobacteria	1224|Proteobacteria	M	Outer membrane lipoprotein-sorting protein	-	-	-	-	-	-	-	-	-	-	-	-	LolA_like
HKD2_k127_3079277_0	314345.SPV1_00752	6.611e-102	345.0	COG4591@1|root,COG4591@2|Bacteria,1RD9H@1224|Proteobacteria	1224|Proteobacteria	M	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HKD2_k127_3079277_1	314345.SPV1_00757	2.027e-98	331.0	COG4591@1|root,COG4591@2|Bacteria,1R4Q2@1224|Proteobacteria	1224|Proteobacteria	M	ABC-type transport system involved in lipoprotein release permease component	VPA0558	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HKD2_k127_3090295_3	1121403.AUCV01000026_gene2328	3.457e-29	121.0	COG0789@1|root,COG0789@2|Bacteria,1RGYB@1224|Proteobacteria,42V1F@68525|delta/epsilon subdivisions,2WR79@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	PFAM regulatory protein, MerR	-	-	-	-	-	-	-	-	-	-	-	-	MerR_1
HKD2_k127_3090295_1	1121403.AUCV01000026_gene2327	1.194e-41	155.0	COG0776@1|root,COG0776@2|Bacteria,1MZ5B@1224|Proteobacteria,42VDU@68525|delta/epsilon subdivisions,2WQZ5@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions	-	-	-	ko:K03530,ko:K04764	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
HKD2_k127_3090295_0	1121403.AUCV01000026_gene2326	4.717e-285	897.0	COG0072@1|root,COG0072@2|Bacteria,1MWKS@1224|Proteobacteria,42M1G@68525|delta/epsilon subdivisions,2WJ7V@28221|Deltaproteobacteria,2MI13@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily	pheT	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,tRNA_bind
HKD2_k127_3090295_2	1121403.AUCV01000026_gene2325	2.787e-35	134.0	COG0016@1|root,COG0016@2|Bacteria,1MVD7@1224|Proteobacteria,42MB0@68525|delta/epsilon subdivisions,2WJ42@28221|Deltaproteobacteria,2MI3B@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily	pheS	GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iAF987.Gmet_1415	Phe_tRNA-synt_N,tRNA-synt_2d
HKD2_k127_3115832_3	1121403.AUCV01000046_gene1097	4.214e-45	165.0	COG0131@1|root,COG0131@2|Bacteria,1MWBS@1224|Proteobacteria,42NIV@68525|delta/epsilon subdivisions,2WNA4@28221|Deltaproteobacteria,2MJMY@213118|Desulfobacterales	28221|Deltaproteobacteria	E	PFAM Imidazoleglycerol-phosphate dehydratase	hisB	GO:0000105,GO:0003674,GO:0003824,GO:0004424,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.2.1.19	ko:K01693	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R03457	RC00932	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPD
HKD2_k127_3115832_4	1167006.UWK_03550	5.348e-29	124.0	2E6CS@1|root,32UMD@2|Bacteria,1R3K9@1224|Proteobacteria,43DKK@68525|delta/epsilon subdivisions,2WQYY@28221|Deltaproteobacteria,2MKMG@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3115832_1	1121403.AUCV01000046_gene1099	1.643e-77	267.0	COG0037@1|root,COG0037@2|Bacteria,1MW5Q@1224|Proteobacteria,42MMC@68525|delta/epsilon subdivisions,2WN12@28221|Deltaproteobacteria,2MI8G@213118|Desulfobacterales	28221|Deltaproteobacteria	D	Belongs to the TtcA family	ttcA	-	-	ko:K14058	-	-	-	-	ko00000,ko03016	-	-	-	ATP_bind_3
HKD2_k127_3115832_2	1167006.UWK_03548	3.871e-75	261.0	COG1578@1|root,COG1578@2|Bacteria,1RI11@1224|Proteobacteria,42RA1@68525|delta/epsilon subdivisions,2WMCD@28221|Deltaproteobacteria,2MIHD@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Protein of unknown function DUF89	-	-	-	ko:K09116	-	-	-	-	ko00000	-	-	-	DUF89
HKD2_k127_3115832_0	1121403.AUCV01000046_gene1104	4.038e-101	334.0	COG0017@1|root,COG0017@2|Bacteria,1MWFV@1224|Proteobacteria,42MJX@68525|delta/epsilon subdivisions,2WJDM@28221|Deltaproteobacteria,2MIBQ@213118|Desulfobacterales	28221|Deltaproteobacteria	J	class II (D K and N)	asnS	-	6.1.1.22	ko:K01893	ko00970,map00970	M00359,M00360	R03648	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
HKD2_k127_3143765_6	247490.KSU1_B0383	2.743e-44	174.0	2E4WW@1|root,32ZQY@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3143765_8	1167006.UWK_02684	7.086e-30	134.0	COG0457@1|root,COG1225@1|root,COG1462@1|root,COG0457@2|Bacteria,COG1225@2|Bacteria,COG1462@2|Bacteria,1NK5T@1224|Proteobacteria	1224|Proteobacteria	M	Curli production assembly/transport component CsgG	-	-	-	-	-	-	-	-	-	-	-	-	CsgG
HKD2_k127_3143765_9	642492.Clole_2515	1.28e-29	134.0	COG2815@1|root,COG2815@2|Bacteria	2|Bacteria	G	serine threonine protein kinase	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,TIR_2
HKD2_k127_3143765_5	1121438.JNJA01000008_gene3867	6.725e-88	318.0	COG1226@1|root,COG2114@1|root,COG1226@2|Bacteria,COG2114@2|Bacteria,1R86S@1224|Proteobacteria,4317C@68525|delta/epsilon subdivisions,2WWWJ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3143765_11	765420.OSCT_0638	6.813e-10	70.0	COG1572@1|root,COG1572@2|Bacteria,2G86R@200795|Chloroflexi,3757A@32061|Chloroflexia	32061|Chloroflexia	G	PFAM peptidase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	NPCBM_assoc,PPC
HKD2_k127_3143765_12	700508.D174_26925	2.097e-08	66.0	COG2931@1|root,COG3391@1|root,COG2931@2|Bacteria,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	3.2.1.4,3.4.24.40	ko:K01179,ko:K01406,ko:K07004	ko00500,ko01100,ko01503,map00500,map01100,map01503	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000,ko01002	-	GH5,GH9	-	Calx-beta,Exo_endo_phos,HemolysinCabind,LTD,Lactonase,Laminin_G_3
HKD2_k127_3143765_4	926550.CLDAP_17040	1.632e-90	334.0	COG5276@1|root,COG5276@2|Bacteria,2G8F2@200795|Chloroflexi	200795|Chloroflexi	S	LVIVD repeat	-	-	-	-	-	-	-	-	-	-	-	-	LVIVD
HKD2_k127_3143765_7	1535422.ND16A_0391	8.716e-42	178.0	COG3292@1|root,COG3637@1|root,COG5492@1|root,COG3292@2|Bacteria,COG3637@2|Bacteria,COG5492@2|Bacteria,1QVUE@1224|Proteobacteria,1T2J5@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	regulator of chromosome condensation, RCC1	-	-	-	-	-	-	-	-	-	-	-	-	OMP_b-brl,fn3
HKD2_k127_3143765_1	1121403.AUCV01000007_gene1247	9.685e-182	575.0	COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,42MXG@68525|delta/epsilon subdivisions,2WJ6G@28221|Deltaproteobacteria,2MJ69@213118|Desulfobacterales	28221|Deltaproteobacteria	E	PFAM aminotransferase class I and II	-	-	2.6.1.1	ko:K11358	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
HKD2_k127_3143765_3	1121403.AUCV01000007_gene1246	1.205e-126	409.0	COG0484@1|root,COG0484@2|Bacteria,1QWQ7@1224|Proteobacteria,43BV3@68525|delta/epsilon subdivisions,2X762@28221|Deltaproteobacteria,2MPKT@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Tellurite resistance protein TerB	-	-	-	ko:K05801	-	-	-	-	ko00000,ko03110	-	-	-	DnaJ,TerB
HKD2_k127_3143765_2	1121403.AUCV01000007_gene1245	2.78e-137	450.0	COG0552@1|root,COG0552@2|Bacteria,1MUDU@1224|Proteobacteria,42N3Z@68525|delta/epsilon subdivisions,2WIPM@28221|Deltaproteobacteria,2MITD@213118|Desulfobacterales	28221|Deltaproteobacteria	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components	ftsY	-	-	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2,3.A.5.7	-	-	SRP54,SRP54_N
HKD2_k127_3143765_0	1121403.AUCV01000007_gene1244	0.0	1176.0	COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,42M9W@68525|delta/epsilon subdivisions,2WJ29@28221|Deltaproteobacteria,2MHRD@213118|Desulfobacterales	28221|Deltaproteobacteria	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	-	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
HKD2_k127_3143765_10	1121403.AUCV01000007_gene1243	4.165e-25	109.0	COG0071@1|root,COG0071@2|Bacteria,1RE2H@1224|Proteobacteria,42RP0@68525|delta/epsilon subdivisions,2WNC4@28221|Deltaproteobacteria,2MK0Y@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
HKD2_k127_3143765_13	1191523.MROS_1025	0.0001823	50.0	COG0446@1|root,COG0446@2|Bacteria	2|Bacteria	Q	pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.5.4	ko:K17218	ko00920,map00920	-	R10152	RC03155	ko00000,ko00001,ko01000	-	-	-	DsrC,Pyr_redox_2
HKD2_k127_3154432_1	1121403.AUCV01000002_gene615	6.665e-143	458.0	COG0481@1|root,COG0481@2|Bacteria,1MVZA@1224|Proteobacteria,42M3D@68525|delta/epsilon subdivisions,2WJEA@28221|Deltaproteobacteria,2MI7F@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner	lepA	-	-	ko:K03596	ko05134,map05134	-	-	-	ko00000,ko00001	-	-	-	EFG_C,EFG_II,GTP_EFTU,GTP_EFTU_D2,LepA_C
HKD2_k127_3154432_0	926550.CLDAP_27190	1.03e-209	689.0	COG1404@1|root,COG5640@1|root,COG1404@2|Bacteria,COG5640@2|Bacteria	2|Bacteria	O	serine-type endopeptidase activity	vpr	GO:0005575,GO:0005576	3.4.21.4	ko:K01312,ko:K14647	ko02024,ko04080,ko04972,ko04974,ko05164,map02024,map04080,map04972,map04974,map05164	-	-	-	ko00000,ko00001,ko01000,ko01002,ko03110,ko04147	-	-	-	FlgD_ig,Inhibitor_I9,PA,Peptidase_S8,SLH,Trypsin,VCBS
HKD2_k127_3170625_1	472759.Nhal_1622	9.545e-84	302.0	COG1145@1|root,COG1148@1|root,COG1145@2|Bacteria,COG1148@2|Bacteria,1MWHY@1224|Proteobacteria,1RZ4B@1236|Gammaproteobacteria,1X06U@135613|Chromatiales	135613|Chromatiales	C	PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
HKD2_k127_3170625_2	1415780.JPOG01000001_gene2738	1.93e-37	151.0	COG3381@1|root,COG3381@2|Bacteria,1MWWM@1224|Proteobacteria,1S449@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	PFAM cytoplasmic chaperone TorD family protein	-	-	-	-	-	-	-	-	-	-	-	-	Nitrate_red_del
HKD2_k127_3170625_0	1415780.JPOG01000001_gene2740	7.708e-97	320.0	COG0243@1|root,COG3383@1|root,COG0243@2|Bacteria,COG3383@2|Bacteria,1MW3N@1224|Proteobacteria,1RN6N@1236|Gammaproteobacteria,1XCEY@135614|Xanthomonadales	135614|Xanthomonadales	C	Molydopterin dinucleotide binding domain	-	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
HKD2_k127_3177876_0	1121403.AUCV01000019_gene3251	0.0	1086.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,42MHP@68525|delta/epsilon subdivisions,2WIQG@28221|Deltaproteobacteria,2MHMH@213118|Desulfobacterales	28221|Deltaproteobacteria	I	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	acsA	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
HKD2_k127_3198738_3	1167006.UWK_01176	9.732e-87	292.0	COG2334@1|root,COG2334@2|Bacteria,1MU2Q@1224|Proteobacteria,42QEX@68525|delta/epsilon subdivisions,2WMFU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	F	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response	srkA	-	-	-	-	-	-	-	-	-	-	-	APH
HKD2_k127_3198738_5	1125863.JAFN01000001_gene381	2.082e-42	170.0	COG2199@1|root,COG3706@2|Bacteria,1REEI@1224|Proteobacteria,42RTM@68525|delta/epsilon subdivisions	1224|Proteobacteria	T	PFAM GGDEF domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,GGDEF,HAMP
HKD2_k127_3198738_4	203122.Sde_0757	2.693e-53	198.0	COG1723@1|root,COG1723@2|Bacteria,1MWYM@1224|Proteobacteria,1S0KZ@1236|Gammaproteobacteria,46B0U@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Uncharacterised ACR, YagE family COG1723	-	-	-	-	-	-	-	-	-	-	-	-	DUF155
HKD2_k127_3198738_1	1121403.AUCV01000027_gene2524	2.057e-131	437.0	COG0642@1|root,COG2205@2|Bacteria,1N58A@1224|Proteobacteria,43D6V@68525|delta/epsilon subdivisions,2X62P@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	2.7.13.3	ko:K07711	ko02020,ko02024,map02020,map02024	M00502	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
HKD2_k127_3198738_0	1268622.AVS7_03545	3.071e-161	519.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VHSB@28216|Betaproteobacteria,4A9V8@80864|Comamonadaceae	28216|Betaproteobacteria	T	response regulator	yfhA	-	-	ko:K07715	ko02020,ko02024,map02020,map02024	M00502	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD2_k127_3198738_2	1123508.JH636439_gene1391	3.671e-116	404.0	COG4191@1|root,COG4191@2|Bacteria,2IWUM@203682|Planctomycetes	203682|Planctomycetes	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
HKD2_k127_3206009_3	335543.Sfum_1939	2.072e-05	49.0	COG0839@1|root,COG0839@2|Bacteria,1MWJV@1224|Proteobacteria,42SDZ@68525|delta/epsilon subdivisions,2WPXS@28221|Deltaproteobacteria,2MSFK@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	PFAM NADH-ubiquinone plastoquinone oxidoreductase chain 6	nuoJ-2	-	1.6.5.3	ko:K00339	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q3
HKD2_k127_3206009_2	335543.Sfum_1938	4.534e-27	117.0	COG0713@1|root,COG0713@2|Bacteria,1RH0S@1224|Proteobacteria,42VAT@68525|delta/epsilon subdivisions,2WRE5@28221|Deltaproteobacteria,2MSHN@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoK-2	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0050136,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204	1.6.5.3	ko:K00340	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q2
HKD2_k127_3206009_0	644968.DFW101_0266	1.281e-158	521.0	COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,42KZE@68525|delta/epsilon subdivisions,2WKU7@28221|Deltaproteobacteria,2MADD@213115|Desulfovibrionales	28221|Deltaproteobacteria	CP	NADH-Ubiquinone oxidoreductase (complex I), chain 5	nuoL	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M,Proton_antipo_N
HKD2_k127_3206009_1	941449.dsx2_2185	1.824e-36	145.0	COG1008@1|root,COG1008@2|Bacteria,1MV7V@1224|Proteobacteria,42MBQ@68525|delta/epsilon subdivisions,2X5HD@28221|Deltaproteobacteria,2M90X@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	NADH-quinone oxidoreductase, chain M	nuoM-2	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
HKD2_k127_3226555_4	401053.AciPR4_3897	1.089e-82	282.0	COG1028@1|root,COG1028@2|Bacteria,3Y35J@57723|Acidobacteria,2JHVV@204432|Acidobacteriia	204432|Acidobacteriia	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HKD2_k127_3226555_2	1232410.KI421412_gene179	1.061e-133	435.0	COG0845@1|root,COG0845@2|Bacteria,1MUFW@1224|Proteobacteria,42N4G@68525|delta/epsilon subdivisions,2WJ8A@28221|Deltaproteobacteria,43TCG@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	HlyD family secretion protein	-	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	HlyD_D23
HKD2_k127_3226555_0	1232410.KI421412_gene178	0.0	1629.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJ8D@28221|Deltaproteobacteria,43S5E@69541|Desulfuromonadales	28221|Deltaproteobacteria	V	AcrB/AcrD/AcrF family	-	-	-	ko:K03296,ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
HKD2_k127_3226555_6	448385.sce0292	1.144e-56	206.0	COG4122@1|root,COG4122@2|Bacteria,1N62B@1224|Proteobacteria,43BAH@68525|delta/epsilon subdivisions,2X6PQ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	O-methyltransferase	-	-	2.1.1.104	ko:K00588	ko00360,ko00940,ko00941,ko00945,ko01100,ko01110,map00360,map00940,map00941,map00945,map01100,map01110	M00039,M00350	R01942,R06578	RC00003,RC00392	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_3
HKD2_k127_3226555_8	243231.GSU0707	4.284e-47	171.0	COG2076@1|root,COG2076@2|Bacteria,1MZ6P@1224|Proteobacteria,42TM1@68525|delta/epsilon subdivisions,2WQK6@28221|Deltaproteobacteria,43VKK@69541|Desulfuromonadales	28221|Deltaproteobacteria	P	Small Multidrug Resistance protein	-	-	-	ko:K11741	-	-	-	-	ko00000,ko02000	2.A.7.1	-	-	Multi_Drug_Res
HKD2_k127_3226555_7	102129.Lepto7375DRAFT_1869	5.774e-55	199.0	COG2860@1|root,COG2860@2|Bacteria,1GD1U@1117|Cyanobacteria	1117|Cyanobacteria	S	UPF0126 domain	-	-	-	-	-	-	-	-	-	-	-	-	UPF0126
HKD2_k127_3226555_13	883126.HMPREF9710_04835	1.372e-23	104.0	COG5569@1|root,COG5569@2|Bacteria,1N8CJ@1224|Proteobacteria,2VVSU@28216|Betaproteobacteria,47524@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Copper binding periplasmic protein CusF	-	-	-	-	-	-	-	-	-	-	-	-	CusF_Ec
HKD2_k127_3226555_16	370438.PTH_0499	6.788e-11	66.0	COG1848@1|root,COG1848@2|Bacteria,1VKNI@1239|Firmicutes,24VDB@186801|Clostridia,266AG@186807|Peptococcaceae	186801|Clostridia	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
HKD2_k127_3226555_14	1121459.AQXE01000001_gene2779	4.066e-20	94.0	2A740@1|root,30VZN@2|Bacteria,1QAMB@1224|Proteobacteria,43691@68525|delta/epsilon subdivisions,2X0TK@28221|Deltaproteobacteria,2MDDC@213115|Desulfovibrionales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3226555_3	251229.Chro_0301	5.108e-99	334.0	COG0604@1|root,COG0604@2|Bacteria,1G0N4@1117|Cyanobacteria	1117|Cyanobacteria	C	NADPH quinone reductase	-	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N_2
HKD2_k127_3226555_10	1168065.DOK_02166	3.62e-41	160.0	COG1285@1|root,COG1285@2|Bacteria,1MURJ@1224|Proteobacteria,1RQUD@1236|Gammaproteobacteria,1J6CI@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	MgtC family	mgtC	GO:0008150,GO:0009405,GO:0044419,GO:0051704	-	ko:K07507	-	-	-	-	ko00000,ko02000	9.B.20	-	-	MgtC
HKD2_k127_3226555_5	1167006.UWK_03474	1.965e-75	262.0	COG1387@1|root,COG1387@2|Bacteria,1RCEG@1224|Proteobacteria,42MIM@68525|delta/epsilon subdivisions,2WNXK@28221|Deltaproteobacteria,2MJV3@213118|Desulfobacterales	28221|Deltaproteobacteria	E	TIGRFAM histidinol phosphate phosphatase HisJ family	-	-	3.1.3.15	ko:K04486	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R03013	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PHP,PHP_C
HKD2_k127_3226555_1	1121403.AUCV01000008_gene1521	6.404e-269	844.0	COG0446@1|root,COG0607@1|root,COG0446@2|Bacteria,COG0607@2|Bacteria,1NR3M@1224|Proteobacteria,42N3G@68525|delta/epsilon subdivisions,2WIS9@28221|Deltaproteobacteria,2MIFG@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Pyridine nucleotide-disulphide oxidoreductase, dimerisation	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,Pyr_redox_dim,Rhodanese
HKD2_k127_3226555_11	671143.DAMO_2925	1.438e-38	153.0	COG1993@1|root,COG1993@2|Bacteria,2NPXF@2323|unclassified Bacteria	2|Bacteria	T	Uncharacterized ACR, COG1993	-	-	-	ko:K06199,ko:K09137	-	-	-	-	ko00000,ko02000	1.A.43.1,1.A.43.2,1.A.43.3	-	-	CBS,DUF190
HKD2_k127_3226555_9	1121403.AUCV01000008_gene1519	8.231e-45	173.0	COG0239@1|root,COG0239@2|Bacteria,1MZNH@1224|Proteobacteria,42V4I@68525|delta/epsilon subdivisions,2WRJJ@28221|Deltaproteobacteria,2MKW0@213118|Desulfobacterales	28221|Deltaproteobacteria	D	Important for reducing fluoride concentration in the cell, thus reducing its toxicity	crcB	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661,GO:1903424,GO:1903425	-	ko:K06199	-	-	-	-	ko00000,ko02000	1.A.43.1,1.A.43.2,1.A.43.3	-	-	CRCB
HKD2_k127_3226555_15	1121403.AUCV01000008_gene1518	9.414e-19	90.0	COG2982@1|root,COG2982@2|Bacteria	2|Bacteria	M	Protein involved in outer membrane biogenesis	CP_0578	-	-	-	-	-	-	-	-	-	-	-	AsmA_2
HKD2_k127_3257759_2	1284680.HMPREF1627_07830	7.626e-15	78.0	COG0586@1|root,COG0586@2|Bacteria,2GN43@201174|Actinobacteria,4D83T@85005|Actinomycetales	201174|Actinobacteria	S	SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
HKD2_k127_3257759_0	234267.Acid_5448	1.187e-120	400.0	COG0156@1|root,COG0156@2|Bacteria	2|Bacteria	E	8-amino-7-oxononanoate synthase activity	bioF	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	2.3.1.29,2.3.1.47	ko:K00639,ko:K00652	ko00260,ko00780,ko01100,map00260,map00780,map01100	M00123,M00573,M00577	R00371,R03210,R10124	RC00004,RC00039,RC00394,RC02725	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
HKD2_k127_3257759_1	1123376.AUIU01000012_gene1445	4.673e-16	89.0	COG0451@1|root,COG0451@2|Bacteria,3J0T9@40117|Nitrospirae	40117|Nitrospirae	M	NmrA-like family	-	-	1.1.1.219	ko:K00091	-	-	-	-	ko00000,ko01000	-	-	-	Epimerase
HKD2_k127_3273902_19	1472716.KBK24_0134390	5.432e-11	64.0	COG2929@1|root,COG2929@2|Bacteria,1N83Z@1224|Proteobacteria,2VVVC@28216|Betaproteobacteria,1KAFW@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Ribonuclease toxin, BrnT, of type II toxin-antitoxin system	-	-	-	ko:K09803	-	-	-	-	ko00000	-	-	-	BrnT_toxin
HKD2_k127_3273902_17	1162668.LFE_2214	6.78e-22	98.0	COG3514@1|root,COG3514@2|Bacteria	2|Bacteria	S	BrnA antitoxin of type II toxin-antitoxin system	-	-	2.5.1.39	ko:K03179	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R05000,R05615	RC00209,RC02895	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	BrnA_antitoxin
HKD2_k127_3273902_14	472759.Nhal_3066	1.229e-37	143.0	COG3636@1|root,COG3636@2|Bacteria,1N75D@1224|Proteobacteria,1SC8G@1236|Gammaproteobacteria,1WYIJ@135613|Chromatiales	1236|Gammaproteobacteria	K	addiction module antidote protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
HKD2_k127_3273902_16	177439.DP0879	7.635e-35	139.0	COG1610@1|root,COG1610@2|Bacteria,1RCQA@1224|Proteobacteria,42R4Q@68525|delta/epsilon subdivisions,2WN2Z@28221|Deltaproteobacteria,2MJMD@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Yqey-like protein	-	-	-	ko:K09117	-	-	-	-	ko00000	-	-	-	YqeY
HKD2_k127_3273902_13	883.DvMF_1051	9.548e-45	169.0	COG0457@1|root,COG0457@2|Bacteria,1N0Q1@1224|Proteobacteria,42TBT@68525|delta/epsilon subdivisions,2WQ96@28221|Deltaproteobacteria,2MCPE@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	SMART Tetratricopeptide	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_16,TPR_2,TPR_6,TPR_8
HKD2_k127_3273902_0	1121403.AUCV01000008_gene1553	7.165e-302	932.0	COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,42M1X@68525|delta/epsilon subdivisions,2WJA2@28221|Deltaproteobacteria,2MHZK@213118|Desulfobacterales	28221|Deltaproteobacteria	EH	TIGRFAM acetolactate synthase, large subunit, biosynthetic type	ilvB	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
HKD2_k127_3273902_8	1121403.AUCV01000008_gene1552	6.807e-78	263.0	COG0440@1|root,COG0440@2|Bacteria,1RAGN@1224|Proteobacteria,42RRU@68525|delta/epsilon subdivisions,2WNBY@28221|Deltaproteobacteria,2MJMK@213118|Desulfobacterales	28221|Deltaproteobacteria	E	TIGRFAM acetolactate synthase, small subunit	ilvN	-	2.2.1.6	ko:K01653	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,ACT_5,ALS_ss_C
HKD2_k127_3273902_9	589865.DaAHT2_0727	7.417e-78	271.0	COG0688@1|root,COG0688@2|Bacteria,1MW45@1224|Proteobacteria,42QDS@68525|delta/epsilon subdivisions,2WMQ3@28221|Deltaproteobacteria,2MJQ8@213118|Desulfobacterales	28221|Deltaproteobacteria	I	Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer)	psd	-	4.1.1.65	ko:K01613	ko00564,ko01100,ko01110,map00564,map01100,map01110	M00093	R02055	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	PS_Dcarbxylase
HKD2_k127_3273902_6	1121403.AUCV01000008_gene1550	1.053e-103	342.0	COG1183@1|root,COG1183@2|Bacteria,1MWD9@1224|Proteobacteria,42QV4@68525|delta/epsilon subdivisions,2WMR6@28221|Deltaproteobacteria,2MJGV@213118|Desulfobacterales	28221|Deltaproteobacteria	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pssA	-	2.7.8.8	ko:K17103	ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110	M00093	R01800	RC00002,RC00017,RC02795	ko00000,ko00001,ko00002,ko01000	-	-	-	CDP-OH_P_transf
HKD2_k127_3273902_12	1121403.AUCV01000008_gene1549	7.716e-49	181.0	COG0742@1|root,COG0742@2|Bacteria,1MXKW@1224|Proteobacteria,42U1F@68525|delta/epsilon subdivisions,2WQQM@28221|Deltaproteobacteria,2MK2T@213118|Desulfobacterales	28221|Deltaproteobacteria	L	PFAM conserved	-	-	2.1.1.171	ko:K08316	-	-	R07234	RC00003	ko00000,ko01000,ko03009	-	-	-	Cons_hypoth95
HKD2_k127_3273902_10	589865.DaAHT2_0546	3.091e-64	227.0	COG0669@1|root,COG0669@2|Bacteria,1RD9F@1224|Proteobacteria,42RJQ@68525|delta/epsilon subdivisions,2WNDS@28221|Deltaproteobacteria,2MJTB@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate	coaD	GO:0003674,GO:0003824,GO:0004595,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.7.3	ko:K00954	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
HKD2_k127_3273902_15	1121403.AUCV01000008_gene1547	1.357e-35	142.0	COG0723@1|root,COG0723@2|Bacteria,1NINP@1224|Proteobacteria,42X9Z@68525|delta/epsilon subdivisions,2WSPW@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM Rieske 2Fe-2S	cbcV	-	1.10.9.1	ko:K02636	ko00195,ko01100,map00195,map01100	M00162	R03817,R08409	RC01002	ko00000,ko00001,ko00002,ko00194,ko01000	-	-	iAF987.Gmet_1922	CytB6-F_Fe-S,Rieske
HKD2_k127_3273902_7	1121403.AUCV01000008_gene1546	8.109e-102	341.0	COG1290@1|root,COG1290@2|Bacteria	2|Bacteria	C	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis	-	-	-	ko:K00412	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002,ko03029	-	-	-	Cytochrom_B_C,Cytochrom_B_N_2,Cytochrome_B
HKD2_k127_3273902_4	1121403.AUCV01000007_gene1219	2.361e-120	391.0	COG3494@1|root,COG3494@2|Bacteria,1MWTH@1224|Proteobacteria,42P40@68525|delta/epsilon subdivisions,2WK7K@28221|Deltaproteobacteria,2MHT1@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF1009)	-	-	-	ko:K09949	-	-	-	-	ko00000	-	-	-	DUF1009
HKD2_k127_3273902_3	1121403.AUCV01000007_gene1218	5.847e-121	393.0	COG1043@1|root,COG1043@2|Bacteria,1MUHQ@1224|Proteobacteria,42NPG@68525|delta/epsilon subdivisions,2WJVP@28221|Deltaproteobacteria,2MI18@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxA	-	2.3.1.129	ko:K00677	ko00540,ko01100,ko01503,map00540,map01100,map01503	M00060	R04567	RC00039,RC00055	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Acetyltransf_11,Hexapep
HKD2_k127_3273902_11	1121403.AUCV01000007_gene1217	2.382e-58	214.0	COG0764@1|root,COG0764@2|Bacteria,1RH2T@1224|Proteobacteria,42SCN@68525|delta/epsilon subdivisions,2WP3E@28221|Deltaproteobacteria,2MK6G@213118|Desulfobacterales	28221|Deltaproteobacteria	I	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs	fabZ	-	4.2.1.59	ko:K02372	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07764,R10117,R10121	RC00831,RC01095	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FabA
HKD2_k127_3273902_5	1121403.AUCV01000007_gene1216	2.834e-114	379.0	COG1044@1|root,COG1044@2|Bacteria,1MUX6@1224|Proteobacteria,42M4X@68525|delta/epsilon subdivisions,2WJJY@28221|Deltaproteobacteria,2MI3C@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxD	GO:0003674,GO:0003824,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016740,GO:0016746,GO:0016747,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	2.3.1.191	ko:K02536	ko00540,ko01100,map00540,map01100	M00060	R04550	RC00039,RC00166	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hexapep,Hexapep_2,LpxD
HKD2_k127_3273902_2	1121403.AUCV01000007_gene1215	4.533e-156	522.0	COG3876@1|root,COG3876@2|Bacteria,1MX3S@1224|Proteobacteria,42N6K@68525|delta/epsilon subdivisions,2WKFH@28221|Deltaproteobacteria,2MI37@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF1343)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1343
HKD2_k127_3273902_1	1121403.AUCV01000046_gene1109	1.289e-212	666.0	COG0449@1|root,COG0449@2|Bacteria,1MW4K@1224|Proteobacteria,42KZ7@68525|delta/epsilon subdivisions,2WJP6@28221|Deltaproteobacteria,2MIWZ@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	iAF987.Gmet_1487	GATase_6,SIS
HKD2_k127_3285161_5	1121403.AUCV01000017_gene4477	6.982e-27	112.0	2D7FD@1|root,32TNY@2|Bacteria,1NAHU@1224|Proteobacteria,42VAC@68525|delta/epsilon subdivisions,2WR6Q@28221|Deltaproteobacteria,2MKKP@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF1992)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1992
HKD2_k127_3285161_4	589865.DaAHT2_2513	3.059e-30	123.0	COG0745@1|root,COG0745@2|Bacteria	589865.DaAHT2_2513|-	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3285161_0	589865.DaAHT2_2512	1.872e-285	902.0	COG0574@1|root,COG3848@1|root,COG0574@2|Bacteria,COG3848@2|Bacteria,1MU0R@1224|Proteobacteria,42MW3@68525|delta/epsilon subdivisions,2WIXV@28221|Deltaproteobacteria,2MIEG@213118|Desulfobacterales	28221|Deltaproteobacteria	GT	pyruvate phosphate dikinase	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PPDK_N
HKD2_k127_3285161_3	589865.DaAHT2_2511	1.443e-66	243.0	2C5J8@1|root,30F9Z@2|Bacteria,1RE16@1224|Proteobacteria,42RYB@68525|delta/epsilon subdivisions,2WNIF@28221|Deltaproteobacteria,2MJSR@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3285161_1	589865.DaAHT2_2510	3.07e-189	600.0	COG0730@1|root,COG0730@2|Bacteria,1MWX2@1224|Proteobacteria,42MRE@68525|delta/epsilon subdivisions,2WIP0@28221|Deltaproteobacteria,2MIDJ@213118|Desulfobacterales	28221|Deltaproteobacteria	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
HKD2_k127_3285161_2	1121403.AUCV01000016_gene4409	2.669e-114	389.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MIZ@68525|delta/epsilon subdivisions,2WIUX@28221|Deltaproteobacteria,2MHR5@213118|Desulfobacterales	28221|Deltaproteobacteria	T	PFAM ATP-binding region ATPase domain protein	-	-	2.7.13.3	ko:K02482	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	CHASE5,HAMP,HATPase_c,HisKA,dCache_1,dCache_2
HKD2_k127_3304729_7	1121403.AUCV01000018_gene3160	8.918e-118	390.0	COG0628@1|root,COG0628@2|Bacteria,1MVX7@1224|Proteobacteria,42P90@68525|delta/epsilon subdivisions,2WK8R@28221|Deltaproteobacteria,2MI3H@213118|Desulfobacterales	28221|Deltaproteobacteria	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
HKD2_k127_3304729_5	1167006.UWK_01376	2.206e-153	492.0	COG0115@1|root,COG0115@2|Bacteria,1MVB0@1224|Proteobacteria,42MKX@68525|delta/epsilon subdivisions,2WJ7X@28221|Deltaproteobacteria,2MIWF@213118|Desulfobacterales	28221|Deltaproteobacteria	E	TIGRFAM branched-chain amino acid aminotransferase	ilvE	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	iAF987.Gmet_2853	Aminotran_4
HKD2_k127_3304729_19	589865.DaAHT2_2176	7.324e-42	158.0	COG0234@1|root,COG0234@2|Bacteria,1MZ2X@1224|Proteobacteria,42U7E@68525|delta/epsilon subdivisions,2WPZP@28221|Deltaproteobacteria,2MKH2@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter	groS	-	-	ko:K04078	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Cpn10
HKD2_k127_3304729_1	1121403.AUCV01000018_gene3157	8.096e-311	957.0	COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,42M52@68525|delta/epsilon subdivisions,2WIRK@28221|Deltaproteobacteria,2MHPV@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	-	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
HKD2_k127_3304729_13	1121448.DGI_1014	2.048e-72	255.0	2CIBN@1|root,2Z8JT@2|Bacteria,1QGIJ@1224|Proteobacteria,42S2V@68525|delta/epsilon subdivisions,2WNZ1@28221|Deltaproteobacteria,2MA36@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3304729_9	335543.Sfum_0688	8.568e-96	331.0	COG2206@1|root,COG2206@2|Bacteria,1N5T4@1224|Proteobacteria,43AMJ@68525|delta/epsilon subdivisions,2X61J@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	SMART Metal-dependent phosphohydrolase, HD region	-	-	-	-	-	-	-	-	-	-	-	-	DUF3391,HD,HD_5
HKD2_k127_3304729_17	335543.Sfum_0687	6.361e-51	202.0	COG1413@1|root,COG1413@2|Bacteria,1P1H4@1224|Proteobacteria,431VX@68525|delta/epsilon subdivisions,2WWU3@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3304729_8	335543.Sfum_2869	5.528e-98	331.0	COG3108@1|root,COG3108@2|Bacteria,1MWW2@1224|Proteobacteria,42U9S@68525|delta/epsilon subdivisions,2WQ1X@28221|Deltaproteobacteria,2MR6T@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Bacterial protein of unknown function (DUF882)	ycbK	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M15_2
HKD2_k127_3304729_4	1304885.AUEY01000018_gene1094	8.753e-165	522.0	COG0306@1|root,COG0306@2|Bacteria,1MVXK@1224|Proteobacteria,42Q5K@68525|delta/epsilon subdivisions,2X5HI@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	PFAM phosphate transporter	pit	-	-	ko:K03306	-	-	-	-	ko00000	2.A.20	-	-	PHO4
HKD2_k127_3304729_11	1304885.AUEY01000018_gene1093	3.575e-77	263.0	COG1392@1|root,COG1392@2|Bacteria,1PKQW@1224|Proteobacteria,4374X@68525|delta/epsilon subdivisions,2X25A@28221|Deltaproteobacteria,2MP8C@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Protein of unknown function DUF47	-	-	-	-	-	-	-	-	-	-	-	-	PhoU_div
HKD2_k127_3304729_16	1121403.AUCV01000004_gene1983	1.108e-51	195.0	COG1539@1|root,COG1539@2|Bacteria,1QVAP@1224|Proteobacteria,43BPU@68525|delta/epsilon subdivisions,2X712@28221|Deltaproteobacteria,2MPJW@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Putative molybdenum carrier	-	-	-	-	-	-	-	-	-	-	-	-	MoCo_carrier
HKD2_k127_3304729_12	706587.Desti_3519	1.117e-75	264.0	COG0803@1|root,COG0803@2|Bacteria,1MVW9@1224|Proteobacteria,42MBX@68525|delta/epsilon subdivisions,2WJYG@28221|Deltaproteobacteria,2MRPD@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	Belongs to the bacterial solute-binding protein 9 family	-	-	-	ko:K09815	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	ZnuA
HKD2_k127_3304729_6	667014.Thein_0239	9.229e-125	406.0	COG2863@1|root,COG2863@2|Bacteria,2GIKT@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	C	Cytochrome c554 and c-prime	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554
HKD2_k127_3304729_18	667014.Thein_0238	1.905e-48	175.0	2C5I4@1|root,33FNH@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3304729_15	1121403.AUCV01000004_gene1976	1.75e-58	207.0	COG1959@1|root,COG1959@2|Bacteria,1MZ1C@1224|Proteobacteria,42SPF@68525|delta/epsilon subdivisions,2WPVC@28221|Deltaproteobacteria,2MM91@213118|Desulfobacterales	28221|Deltaproteobacteria	K	TIGRFAM transcriptional regulator, Rrf2 family	-	-	-	-	-	-	-	-	-	-	-	-	Rrf2
HKD2_k127_3304729_22	1167006.UWK_01592	2.298e-20	94.0	2E3BY@1|root,32YBB@2|Bacteria,1NDZS@1224|Proteobacteria,42X6C@68525|delta/epsilon subdivisions,2WSF7@28221|Deltaproteobacteria,2MPAM@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF4492)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4492
HKD2_k127_3304729_2	1121403.AUCV01000004_gene1975	1.608e-233	731.0	COG1271@1|root,COG1271@2|Bacteria,1MV60@1224|Proteobacteria,42MB8@68525|delta/epsilon subdivisions,2WIW7@28221|Deltaproteobacteria,2MID8@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM cytochrome bd ubiquinol oxidase subunit I	cydA	-	1.10.3.14	ko:K00425	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	Cyt_bd_oxida_I
HKD2_k127_3304729_3	1121403.AUCV01000004_gene1974	5.98e-169	538.0	COG1294@1|root,COG1294@2|Bacteria,1MURP@1224|Proteobacteria,42NHN@68525|delta/epsilon subdivisions	1224|Proteobacteria	C	Cytochrome d ubiquinol oxidase, subunit II	cydB	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0016679,GO:0016682,GO:0019646,GO:0020037,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0046906,GO:0048037,GO:0055114,GO:0070069,GO:0071944,GO:0097159,GO:1901363	1.10.3.14	ko:K00426	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	iECABU_c1320.ECABU_c10120,iLF82_1304.LF82_0101,iNRG857_1313.NRG857_04455,iPC815.YPO1118,ic_1306.c1120	Cyt_bd_oxida_II
HKD2_k127_3304729_0	1167006.UWK_01596	0.0	1079.0	COG0714@1|root,COG0714@2|Bacteria	2|Bacteria	KLT	Associated with various cellular activities	-	-	-	ko:K04748	-	-	R00294	RC02794	ko00000	3.D.4.10	-	-	AAA,AAA_5,DUF3987,Prim-Pol
HKD2_k127_3304729_10	246197.MXAN_7103	5.468e-78	269.0	COG1352@1|root,COG1352@2|Bacteria,1RDBE@1224|Proteobacteria,42RSH@68525|delta/epsilon subdivisions,2WNHY@28221|Deltaproteobacteria,2YXP4@29|Myxococcales	28221|Deltaproteobacteria	NT	Methyltransferase, chemotaxis proteins	-	-	2.1.1.80	ko:K00575	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko01000,ko02035	-	-	-	CheR,CheR_N
HKD2_k127_3304729_14	1232410.KI421421_gene3477	4.155e-59	213.0	2CHSG@1|root,316CZ@2|Bacteria,1PXCU@1224|Proteobacteria,4308W@68525|delta/epsilon subdivisions,2WVAX@28221|Deltaproteobacteria,43V1W@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF4149)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4149
HKD2_k127_3304729_21	638303.Thal_1145	1.464e-24	111.0	COG4085@1|root,COG4085@2|Bacteria	2|Bacteria	S	PFAM nucleic acid binding, OB-fold, tRNA	yhcR	-	3.1.31.1	ko:K01174	-	-	-	-	ko00000,ko01000	-	-	-	5_nucleotid_C,Gram_pos_anchor,Metallophos,PLDc_2,SNase
HKD2_k127_3321906_2	1167006.UWK_02481	5.25e-06	50.0	COG1216@1|root,COG1216@2|Bacteria,1QXPI@1224|Proteobacteria,43C5D@68525|delta/epsilon subdivisions,2X7YV@28221|Deltaproteobacteria,2MPKW@213118|Desulfobacterales	28221|Deltaproteobacteria	S	PFAM Glycosyl transferase family 2	-	-	-	ko:K07011	-	-	-	-	ko00000	-	-	-	Glycos_transf_2
HKD2_k127_3321906_0	1121403.AUCV01000001_gene941	1.356e-81	280.0	COG1216@1|root,COG1216@2|Bacteria,1R9NA@1224|Proteobacteria	1224|Proteobacteria	S	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HKD2_k127_3321906_1	1121403.AUCV01000001_gene942	1.242e-78	275.0	COG1216@1|root,COG1216@2|Bacteria,1N1TF@1224|Proteobacteria	1224|Proteobacteria	M	PFAM Glycosyl transferase family 2	rfbN	-	-	ko:K12992	ko02025,map02025	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01005	-	GT2	-	Glyco_tranf_2_3,Glycos_transf_2
HKD2_k127_3340403_1	1049564.TevJSym_ab01020	3.059e-59	211.0	2A20V@1|root,30QAU@2|Bacteria,1RDQH@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3340403_2	1121287.AUMU01000011_gene676	5.972e-14	77.0	COG5563@1|root,COG5563@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	FG-GAP_2,Metallophos,Pur_ac_phosph_N
HKD2_k127_3340403_0	589865.DaAHT2_0986	5.858e-169	544.0	COG1643@1|root,COG1643@2|Bacteria,1MUEQ@1224|Proteobacteria,42MD4@68525|delta/epsilon subdivisions,2WJ7Z@28221|Deltaproteobacteria,2MHYR@213118|Desulfobacterales	28221|Deltaproteobacteria	L	ATP-dependent helicase HrpB	hrpB	-	3.6.4.13	ko:K03579	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,HA2,Helicase_C,HrpB_C
HKD2_k127_3352545_0	690850.Desaf_2558	3.743e-222	709.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,42M2R@68525|delta/epsilon subdivisions,2WJ4J@28221|Deltaproteobacteria,2M829@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	Heavy metal transport detoxification protein	copA	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
HKD2_k127_3379511_1	1408473.JHXO01000008_gene2833	4.44e-159	506.0	COG4870@1|root,COG4870@2|Bacteria,4NQK4@976|Bacteroidetes	976|Bacteroidetes	O	Papain family cysteine protease	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C1
HKD2_k127_3379511_3	1121403.AUCV01000041_gene189	1.105e-41	156.0	COG2033@1|root,COG2033@2|Bacteria,1N615@1224|Proteobacteria	1224|Proteobacteria	C	Desulfoferrodoxin	-	-	1.15.1.2	ko:K05919	-	-	-	-	ko00000,ko01000	-	-	-	Desulfoferrodox
HKD2_k127_3379511_4	485915.Dret_2515	5.871e-30	126.0	COG1525@1|root,COG1525@2|Bacteria,1N145@1224|Proteobacteria,42SG5@68525|delta/epsilon subdivisions,2WNPI@28221|Deltaproteobacteria,2MCRU@213115|Desulfovibrionales	28221|Deltaproteobacteria	L	PFAM nuclease (SNase domain protein)	-	-	-	-	-	-	-	-	-	-	-	-	Ada_Zn_binding,Excalibur,SNase
HKD2_k127_3379511_0	1167006.UWK_00208	1.25e-194	621.0	2EZKA@1|root,33SRC@2|Bacteria,1NSR5@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3379511_2	1121403.AUCV01000033_gene3654	2.401e-79	270.0	COG1280@1|root,COG1280@2|Bacteria,1RJBR@1224|Proteobacteria,42T9G@68525|delta/epsilon subdivisions,2WP76@28221|Deltaproteobacteria,2MKPW@213118|Desulfobacterales	28221|Deltaproteobacteria	E	LysE type translocator	-	-	-	-	-	-	-	-	-	-	-	-	LysE
HKD2_k127_3379511_5	1121451.DESAM_22152	9.996e-11	62.0	COG0778@1|root,COG1145@1|root,COG0778@2|Bacteria,COG1145@2|Bacteria,1R42D@1224|Proteobacteria,42Q57@68525|delta/epsilon subdivisions,2WNIW@28221|Deltaproteobacteria,2MB6I@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	PFAM Nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_4,Fer4_9,Nitroreductase
HKD2_k127_3443995_1	1121403.AUCV01000006_gene399	9.464e-13	71.0	COG3242@1|root,COG3242@2|Bacteria	2|Bacteria	S	Uncharacterized protein conserved in bacteria (DUF2065)	yjeT	-	-	ko:K09937	-	-	-	-	ko00000	-	-	-	DUF2065
HKD2_k127_3443995_0	1121403.AUCV01000006_gene400	4.247e-160	511.0	COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,42MA7@68525|delta/epsilon subdivisions,2WIPC@28221|Deltaproteobacteria,2MI8B@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Acts as a magnesium transporter	-	-	-	ko:K06213	-	-	-	-	ko00000,ko02000	1.A.26.1	-	-	CBS,MgtE,MgtE_N
HKD2_k127_3451709_0	1121456.ATVA01000001_gene3073	1.52e-111	379.0	COG0574@1|root,COG3848@1|root,COG0574@2|Bacteria,COG3848@2|Bacteria,1QFX3@1224|Proteobacteria,42PIP@68525|delta/epsilon subdivisions,2WKWI@28221|Deltaproteobacteria,2MG9J@213115|Desulfovibrionales	28221|Deltaproteobacteria	G	PFAM Pyruvate phosphate dikinase, PEP pyruvate-binding	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PPDK_N
HKD2_k127_34894_0	1121403.AUCV01000031_gene2839	3.584e-140	462.0	2DKWY@1|root,30NX3@2|Bacteria,1RBMB@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S74
HKD2_k127_34894_1	1232410.KI421413_gene780	6.06e-42	162.0	COG1309@1|root,COG1309@2|Bacteria,1QENQ@1224|Proteobacteria,42TNJ@68525|delta/epsilon subdivisions,2WR2U@28221|Deltaproteobacteria,43UW9@69541|Desulfuromonadales	28221|Deltaproteobacteria	K	Bacterial transcriptional repressor C-terminal	-	-	-	ko:K16137	-	-	-	-	ko00000,ko03000	-	-	-	TetR_C_13,TetR_N
HKD2_k127_3498277_0	1304885.AUEY01000002_gene358	4.833e-184	586.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJVV@28221|Deltaproteobacteria,2MI2Z@213118|Desulfobacterales	28221|Deltaproteobacteria	V	Hydrophobe Amphiphile Efflux-1 (HAE1) Family	bepE	-	-	ko:K03296,ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
HKD2_k127_3498277_1	1267535.KB906767_gene1084	2.497e-31	131.0	COG1538@1|root,COG1538@2|Bacteria,3Y2NR@57723|Acidobacteria,2JHZY@204432|Acidobacteriia	204432|Acidobacteriia	MU	TIGRFAM RND efflux system, outer membrane lipoprotein, NodT	-	-	-	ko:K18139	ko01501,ko02024,map01501,map02024	M00642,M00643,M00647,M00718,M00768,M00822	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	1.B.17,2.A.6.2	-	-	OEP
HKD2_k127_35593_2	589865.DaAHT2_1393	1.407e-104	358.0	28M0D@1|root,2ZAFE@2|Bacteria,1R6YH@1224|Proteobacteria,42NPF@68525|delta/epsilon subdivisions,2WM7K@28221|Deltaproteobacteria,2MIG7@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Putative ATP-binding cassette	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran_2
HKD2_k127_35593_3	589865.DaAHT2_1392	4.842e-102	337.0	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,42QN5@68525|delta/epsilon subdivisions,2WMD7@28221|Deltaproteobacteria,2MJC9@213118|Desulfobacterales	28221|Deltaproteobacteria	V	PFAM ABC transporter related	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD2_k127_35593_1	589865.DaAHT2_1391	1.235e-121	406.0	COG1305@1|root,COG1305@2|Bacteria,1RARF@1224|Proteobacteria,42R14@68525|delta/epsilon subdivisions,2WN3R@28221|Deltaproteobacteria,2MJNR@213118|Desulfobacterales	28221|Deltaproteobacteria	E	PFAM transglutaminase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Transglut_core
HKD2_k127_35593_0	589865.DaAHT2_1105	4.056e-132	427.0	COG0059@1|root,COG0059@2|Bacteria,1MV7M@1224|Proteobacteria,42MRS@68525|delta/epsilon subdivisions,2WJW8@28221|Deltaproteobacteria,2MIRN@213118|Desulfobacterales	28221|Deltaproteobacteria	EH	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by	ilvC	-	1.1.1.86	ko:K00053	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R03051,R04439,R04440,R05068,R05069,R05071	RC00726,RC00836,RC00837,RC01726	ko00000,ko00001,ko00002,ko01000	-	-	-	IlvC,IlvN
HKD2_k127_3568920_6	1209072.ALBT01000046_gene2566	2.067e-45	171.0	COG1629@1|root,COG4771@2|Bacteria,1MUC1@1224|Proteobacteria,1RNHR@1236|Gammaproteobacteria,1FI87@10|Cellvibrio	1236|Gammaproteobacteria	P	Outer membrane protein beta-barrel family	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
HKD2_k127_3568920_0	1167006.UWK_01245	1.279e-117	384.0	COG0648@1|root,COG0648@2|Bacteria,1MX4Y@1224|Proteobacteria,42MYE@68525|delta/epsilon subdivisions,2WJC7@28221|Deltaproteobacteria,2MIWS@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin	nfo	GO:0003674,GO:0003824,GO:0003906,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008081,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0033554,GO:0034641,GO:0042578,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360	3.1.21.2	ko:K01151	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AP_endonuc_2
HKD2_k127_3568920_1	1121403.AUCV01000032_gene2889	3.501e-114	374.0	COG0496@1|root,COG0496@2|Bacteria,1MVHE@1224|Proteobacteria,42N0I@68525|delta/epsilon subdivisions,2WMUX@28221|Deltaproteobacteria,2MJHY@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates	surE	-	3.1.3.5	ko:K03787	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	SurE
HKD2_k127_3568920_5	644282.Deba_2464	6.184e-58	216.0	COG4822@1|root,COG4822@2|Bacteria,1P36Y@1224|Proteobacteria,42P9C@68525|delta/epsilon subdivisions,2WK8C@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	Catalyzes the insertion of Co(2 ) into sirohydrochlorin	cbiKp	GO:0003674,GO:0003824,GO:0004325,GO:0005488,GO:0005575,GO:0005623,GO:0008150,GO:0009987,GO:0016043,GO:0016829,GO:0016852,GO:0020037,GO:0022607,GO:0042597,GO:0043167,GO:0043169,GO:0043933,GO:0044085,GO:0044464,GO:0046872,GO:0046906,GO:0046914,GO:0048037,GO:0050897,GO:0051259,GO:0051262,GO:0051266,GO:0065003,GO:0071840,GO:0097159,GO:1901363	4.99.1.3	ko:K02190	ko00860,ko01100,map00860,map01100	-	R05807	RC01012	ko00000,ko00001,ko01000	-	-	-	CbiK
HKD2_k127_3568920_4	555779.Dthio_PD2854	1.781e-75	276.0	COG1120@1|root,COG1120@2|Bacteria,1MUNG@1224|Proteobacteria,42P8N@68525|delta/epsilon subdivisions,2WIWA@28221|Deltaproteobacteria,2M9KN@213115|Desulfovibrionales	28221|Deltaproteobacteria	HP	PFAM ABC transporter related	-	-	3.6.3.34	ko:K02013	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14	-	-	ABC_tran
HKD2_k127_3568920_2	589865.DaAHT2_1559	1.629e-105	353.0	COG0609@1|root,COG0609@2|Bacteria,1MV9W@1224|Proteobacteria,42PIH@68525|delta/epsilon subdivisions,2WJH2@28221|Deltaproteobacteria,2MIKZ@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily	-	-	-	ko:K02015	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	FecCD
HKD2_k127_3568920_3	589865.DaAHT2_1558	4.947e-87	296.0	COG0614@1|root,COG0614@2|Bacteria,1MWVF@1224|Proteobacteria,42PQA@68525|delta/epsilon subdivisions,2WKNZ@28221|Deltaproteobacteria,2MIYZ@213118|Desulfobacterales	28221|Deltaproteobacteria	P	PFAM periplasmic binding protein	-	-	-	ko:K02016	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	Peripla_BP_2
HKD2_k127_3568920_7	1125863.JAFN01000001_gene2853	2.228e-21	98.0	COG0810@1|root,COG0810@2|Bacteria,1MZPX@1224|Proteobacteria,42VSU@68525|delta/epsilon subdivisions,2WR9P@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Gram-negative bacterial TonB protein C-terminal	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	TonB_C
HKD2_k127_3599454_2	556269.ACDQ01000002_gene984	6.133e-09	69.0	COG2885@1|root,COG2982@1|root,COG2885@2|Bacteria,COG2982@2|Bacteria,1MUME@1224|Proteobacteria,2VIKY@28216|Betaproteobacteria,4738B@75682|Oxalobacteraceae	28216|Betaproteobacteria	M	Domain of Unknown Function (DUF748)	-	-	-	-	-	-	-	-	-	-	-	-	DUF748
HKD2_k127_3599454_3	589865.DaAHT2_0300	0.0006847	53.0	COG3164@1|root,COG3164@2|Bacteria	2|Bacteria	D	Protein of unknown function	-	-	-	-	-	-	-	-	-	-	-	-	AsmA_2,DUF3971,DUF748,Glyco_hydro_106,TamB
HKD2_k127_3599454_0	1121403.AUCV01000007_gene1250	1.1e-99	331.0	COG1624@1|root,COG1624@2|Bacteria,1PEQT@1224|Proteobacteria,42P5A@68525|delta/epsilon subdivisions,2WKPP@28221|Deltaproteobacteria,2MIQR@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria	dacA	-	2.7.7.85	ko:K18672	-	-	-	-	ko00000,ko01000	-	-	-	DisA_N,YbbR
HKD2_k127_3599454_1	1121403.AUCV01000007_gene1249	1.884e-73	257.0	COG4856@1|root,COG4856@2|Bacteria,1REEU@1224|Proteobacteria,42RY2@68525|delta/epsilon subdivisions,2WNZH@28221|Deltaproteobacteria,2MIQJ@213118|Desulfobacterales	28221|Deltaproteobacteria	S	YbbR-like protein	-	-	-	-	-	-	-	-	-	-	-	-	YbbR
HKD2_k127_3623967_5	338966.Ppro_1409	6.808e-70	243.0	COG2518@1|root,COG2518@2|Bacteria,1RC4G@1224|Proteobacteria,43E9Z@68525|delta/epsilon subdivisions,2X7S5@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	PFAM Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
HKD2_k127_3623967_7	338966.Ppro_1409	5.709e-12	66.0	COG2518@1|root,COG2518@2|Bacteria,1RC4G@1224|Proteobacteria,43E9Z@68525|delta/epsilon subdivisions,2X7S5@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	PFAM Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
HKD2_k127_3623967_2	1121405.dsmv_0093	1.402e-122	407.0	COG2067@1|root,COG2067@2|Bacteria,1MUU4@1224|Proteobacteria,42N9J@68525|delta/epsilon subdivisions,2WK7H@28221|Deltaproteobacteria,2MKSB@213118|Desulfobacterales	28221|Deltaproteobacteria	I	PFAM Outer membrane protein transport protein (OMPP1 FadL TodX)	-	-	-	ko:K06076	-	-	-	-	ko00000,ko02000	1.B.9	-	-	Toluene_X
HKD2_k127_3623967_3	1123508.JH636445_gene6557	6.551e-112	392.0	COG4191@1|root,COG4191@2|Bacteria,2IWUM@203682|Planctomycetes	203682|Planctomycetes	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
HKD2_k127_3623967_1	443143.GM18_2161	5.265e-163	537.0	COG0515@1|root,COG0515@2|Bacteria,1N9V2@1224|Proteobacteria,42Q0B@68525|delta/epsilon subdivisions,2WJXJ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	KLT	type IV pilus assembly PilZ	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3623967_6	1167006.UWK_01267	6.113e-54	202.0	COG1763@1|root,COG1763@2|Bacteria,1RD3Q@1224|Proteobacteria	1224|Proteobacteria	H	molybdopterin-guanine dinucleotide biosynthesis protein	mobB	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0005488,GO:0005525,GO:0017076,GO:0019001,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363	2.7.7.77	ko:K03753,ko:K13818	ko00790,ko01100,map00790,map01100	-	R11581	-	ko00000,ko00001,ko01000	-	-	iB21_1397.B21_03691,iBWG_1329.BWG_3527,iECBD_1354.ECBD_4174,iECDH1ME8569_1439.ECDH1ME8569_3728,iEcDH1_1363.EcDH1_4130,iJO1366.b3856,iSbBS512_1146.SbBS512_E4328,iY75_1357.Y75_RS17805	MobB
HKD2_k127_3623967_4	1167006.UWK_01295	9.339e-109	359.0	COG1526@1|root,COG1526@2|Bacteria,1NRU0@1224|Proteobacteria,42PRH@68525|delta/epsilon subdivisions,2WS7D@28221|Deltaproteobacteria,2MPZ2@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH	fdhD	-	-	ko:K02379	-	-	-	-	ko00000	-	-	-	FdhD-NarQ
HKD2_k127_3623967_0	1121403.AUCV01000007_gene1248	3.077e-233	728.0	COG1109@1|root,COG1109@2|Bacteria,1MU24@1224|Proteobacteria,42M6I@68525|delta/epsilon subdivisions,2WJTV@28221|Deltaproteobacteria,2MI6W@213118|Desulfobacterales	28221|Deltaproteobacteria	G	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate	glmM	-	5.4.2.10	ko:K03431	ko00520,ko01100,ko01130,map00520,map01100,map01130	-	R02060	RC00408	ko00000,ko00001,ko01000	-	-	iAF987.Gmet_1886	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
HKD2_k127_3663947_0	1167006.UWK_00303	2.342e-268	841.0	COG0633@1|root,COG3894@1|root,COG0633@2|Bacteria,COG3894@2|Bacteria,1MV6C@1224|Proteobacteria,42MF5@68525|delta/epsilon subdivisions,2WKC6@28221|Deltaproteobacteria,2MI52@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM ferredoxin	-	-	-	-	-	-	-	-	-	-	-	-	DUF4445,Fer2
HKD2_k127_3663947_1	1167006.UWK_00302	1.11e-58	208.0	COG0543@1|root,COG0543@2|Bacteria,1R6QZ@1224|Proteobacteria,42MVW@68525|delta/epsilon subdivisions,2WNRN@28221|Deltaproteobacteria,2MPYR@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B	-	-	-	-	-	-	-	-	-	-	-	-	DHODB_Fe-S_bind,FAD_binding_6,NAD_binding_1
HKD2_k127_3677139_0	96561.Dole_0362	5.308e-155	501.0	COG2211@1|root,COG2211@2|Bacteria,1QVH9@1224|Proteobacteria,43BQR@68525|delta/epsilon subdivisions,2X71T@28221|Deltaproteobacteria,2MKDF@213118|Desulfobacterales	28221|Deltaproteobacteria	G	Sugar (and other) transporter	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD2_k127_3677139_1	156889.Mmc1_2859	1.227e-33	139.0	COG3012@1|root,COG3318@1|root,COG3012@2|Bacteria,COG3318@2|Bacteria,1R4KR@1224|Proteobacteria,2U3DY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	U	SEC-C motif	-	-	-	ko:K07039	-	-	-	-	ko00000	-	-	-	SEC-C,UPF0149
HKD2_k127_3684548_21	266117.Rxyl_3103	2.408e-06	53.0	COG3551@1|root,COG3551@2|Bacteria	2|Bacteria	J	Protein conserved in bacteria	-	-	-	ko:K20444	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.1.3	GT2,GT4	-	Glyco_transf_4,Glycos_transf_1,Glycos_transf_2,Sulfotransfer_3
HKD2_k127_3684548_4	483218.BACPEC_02344	1.854e-115	387.0	COG1134@1|root,COG1134@2|Bacteria,1TQKK@1239|Firmicutes,24A5V@186801|Clostridia,26AUP@186813|unclassified Clostridiales	186801|Clostridia	GM	Wzt C-terminal domain	-	-	3.6.3.40	ko:K01990,ko:K09691,ko:K09693	ko02010,map02010	M00250,M00251,M00254	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.103,3.A.1.104	-	-	ABC_tran,Wzt_C
HKD2_k127_3684548_6	1499967.BAYZ01000049_gene2758	4.254e-104	344.0	COG1682@1|root,COG1682@2|Bacteria,2NQ2H@2323|unclassified Bacteria	2|Bacteria	U	ABC-2 type transporter	rfbA5	-	-	ko:K09690,ko:K09692	ko02010,map02010	M00250,M00251	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.103,3.A.1.104	-	-	ABC2_membrane
HKD2_k127_3684548_0	314345.SPV1_00210	3.856e-218	694.0	COG1086@1|root,COG1086@2|Bacteria,1MWKY@1224|Proteobacteria	1224|Proteobacteria	GM	Polysaccharide biosynthesis protein	pglF	-	4.2.1.135	ko:K15912	ko00520,map00520	-	-	-	ko00000,ko00001,ko01000	-	-	-	CoA_binding_3,Polysacc_synt_2
HKD2_k127_3684548_12	1292035.H476_0597	2.365e-52	192.0	COG2148@1|root,COG2148@2|Bacteria,1TP7V@1239|Firmicutes,25AZD@186801|Clostridia,25TS0@186804|Peptostreptococcaceae	186801|Clostridia	M	Bacterial sugar transferase	pglB	-	-	-	-	-	-	-	-	-	-	-	Bac_transf
HKD2_k127_3684548_1	926550.CLDAP_40290	2.48e-157	505.0	COG0399@1|root,COG0399@2|Bacteria,2G7XI@200795|Chloroflexi	200795|Chloroflexi	E	DegT/DnrJ/EryC1/StrS aminotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
HKD2_k127_3684548_15	398767.Glov_1492	3.019e-41	162.0	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_7
HKD2_k127_3684548_11	234267.Acid_4857	7.252e-56	210.0	COG0438@1|root,COG0438@2|Bacteria,3Y5Q4@57723|Acidobacteria	57723|Acidobacteria	M	Glycosyl transferase 4-like	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
HKD2_k127_3684548_19	886379.AEWI01000052_gene2670	3.984e-11	75.0	COG0438@1|root,COG0438@2|Bacteria,4NZMT@976|Bacteroidetes,2G1JS@200643|Bacteroidia,3XKI2@558415|Marinilabiliaceae	976|Bacteroidetes	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4
HKD2_k127_3684548_3	1121403.AUCV01000032_gene2909	1.82e-139	452.0	COG0381@1|root,COG0381@2|Bacteria,1QUYI@1224|Proteobacteria,42MSY@68525|delta/epsilon subdivisions,2WJXR@28221|Deltaproteobacteria,2MIGG@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Belongs to the UDP-N-acetylglucosamine 2-epimerase family	wecB	-	5.1.3.14	ko:K01791	ko00520,ko01100,ko05111,map00520,map01100,map05111	M00362	R00420	RC00290	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Epimerase_2
HKD2_k127_3684548_10	56110.Oscil6304_1708	1.628e-95	326.0	COG0438@1|root,COG0438@2|Bacteria,1G2DD@1117|Cyanobacteria	1117|Cyanobacteria	M	PFAM Glycosyl transferases group 1	-	-	-	ko:K16703	-	-	-	-	ko00000,ko01000,ko01003	-	GT4	-	Glyco_transf_4,Glycos_transf_1
HKD2_k127_3684548_13	768671.ThimaDRAFT_1491	3.652e-45	173.0	COG0500@1|root,COG2226@2|Bacteria,1RJDW@1224|Proteobacteria,1SP0A@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	Mycolic acid cyclopropane synthetase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3684548_7	941449.dsx2_1094	7.961e-101	335.0	COG0500@1|root,COG2226@2|Bacteria,1N867@1224|Proteobacteria,4310U@68525|delta/epsilon subdivisions	1224|Proteobacteria	Q	Nodulation protein S (NodS)	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
HKD2_k127_3684548_5	926569.ANT_20140	1.167e-110	369.0	COG0463@1|root,COG0463@2|Bacteria,2G5JH@200795|Chloroflexi	2|Bacteria	M	PFAM Glycosyl transferase family 2	wcqE	-	2.4.2.53	ko:K10012	ko00520,ko01503,map00520,map01503	M00721,M00761	R07661	RC00005,RC02954	ko00000,ko00001,ko00002,ko01000,ko01005,ko02000	4.D.2.1.8	GT2	-	Glycos_transf_2
HKD2_k127_3684548_18	344747.PM8797T_02679	5.198e-12	79.0	2E706@1|root,331J5@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3684548_14	1340434.AXVA01000005_gene4869	2.655e-44	177.0	COG5434@1|root,COG5434@2|Bacteria,1TSQD@1239|Firmicutes,4IQIP@91061|Bacilli,1ZRK9@1386|Bacillus	91061|Bacilli	M	Periplasmic copper-binding protein (NosD)	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix
HKD2_k127_3684548_8	1112274.KI911560_gene2578	1.063e-97	324.0	COG0500@1|root,COG0500@2|Bacteria	2|Bacteria	Q	methyltransferase activity	bioC	-	2.1.1.187,2.1.1.197	ko:K00563,ko:K02169	ko00780,ko01100,map00780,map01100	M00572	R07233,R09543	RC00003,RC00460	ko00000,ko00001,ko00002,ko01000,ko03009	-	-	-	Methyltransf_11,Methyltransf_23,Methyltransf_25,Methyltransf_31
HKD2_k127_3684548_23	1540221.JQNI01000002_gene763	0.0005702	51.0	COG2801@1|root,COG2801@2|Bacteria	2|Bacteria	L	transposition	-	-	-	-	-	-	-	-	-	-	-	-	HTH_21,rve
HKD2_k127_3684548_9	1385510.N781_08765	8.568e-96	331.0	COG2244@1|root,COG2244@2|Bacteria,1TPSH@1239|Firmicutes,4HAGX@91061|Bacilli	91061|Bacilli	S	COG2244 Membrane protein involved in the export of O-antigen and teichoic acid	tuaB	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03328,ko:K16694,ko:K16695	-	-	-	-	ko00000,ko02000	2.A.66.2,2.A.66.2.6,2.A.66.2.7	-	iYO844.BSU35600	Polysacc_synt_3,Polysacc_synt_C
HKD2_k127_3684548_17	867845.KI911784_gene1651	6.628e-17	90.0	COG0110@1|root,COG0110@2|Bacteria,2G6D2@200795|Chloroflexi,376J8@32061|Chloroflexia	32061|Chloroflexia	S	PFAM transferase hexapeptide repeat containing protein	-	-	2.3.1.79	ko:K00661	-	-	-	-	ko00000,ko01000	-	-	-	Hexapep
HKD2_k127_3684548_2	1173024.KI912151_gene2204	1.867e-153	493.0	COG0399@1|root,COG0399@2|Bacteria,1G4PM@1117|Cyanobacteria	1117|Cyanobacteria	E	Belongs to the DegT DnrJ EryC1 family	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
HKD2_k127_3684548_22	391596.PBAL39_00185	6.736e-05	54.0	COG1629@1|root,COG1629@2|Bacteria,4NGTE@976|Bacteroidetes,1IVCV@117747|Sphingobacteriia	976|Bacteroidetes	P	CarboxypepD_reg-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarbopepD_reg_2,Plug,STN,TonB_dep_Rec
HKD2_k127_3684548_16	1419583.V466_07790	4.022e-28	128.0	COG3765@1|root,COG3765@2|Bacteria,1PH7X@1224|Proteobacteria,1SXKH@1236|Gammaproteobacteria,1YSJT@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	M	G-rich domain on putative tyrosine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GNVR,Wzz
HKD2_k127_3684548_20	1120934.KB894404_gene549	5.365e-08	56.0	COG1361@1|root,COG4935@1|root,COG1361@2|Bacteria,COG4935@2|Bacteria,2I2W6@201174|Actinobacteria,4EDRS@85010|Pseudonocardiales	201174|Actinobacteria	MO	Proprotein convertase P-domain	-	-	-	-	-	-	-	-	-	-	-	-	P_proprotein,Peptidase_S8
HKD2_k127_3700774_10	526222.Desal_2458	4.278e-08	58.0	COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,42MBP@68525|delta/epsilon subdivisions,2WJAJ@28221|Deltaproteobacteria,2M9MS@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,Pyr_redox_dim
HKD2_k127_3700774_4	1121403.AUCV01000017_gene4551	3.049e-80	279.0	COG0398@1|root,COG0398@2|Bacteria,1MVF3@1224|Proteobacteria,42PFC@68525|delta/epsilon subdivisions,2WKDP@28221|Deltaproteobacteria,2MIRM@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
HKD2_k127_3700774_5	926550.CLDAP_04910	2.865e-77	271.0	COG0837@1|root,COG0837@2|Bacteria,2G7R9@200795|Chloroflexi	200795|Chloroflexi	H	Belongs to the bacterial glucokinase family	glk	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Glucokinase
HKD2_k127_3700774_2	589865.DaAHT2_0048	3.414e-124	408.0	COG0755@1|root,COG0755@2|Bacteria	2|Bacteria	O	cytochrome complex assembly	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C_asm
HKD2_k127_3700774_7	1121937.AUHJ01000009_gene1566	8.025e-70	239.0	COG1970@1|root,COG1970@2|Bacteria,1RHG8@1224|Proteobacteria,1S3PD@1236|Gammaproteobacteria,468KZ@72275|Alteromonadaceae	1236|Gammaproteobacteria	M	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell	mscL	GO:0003674,GO:0005215,GO:0005216,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006884,GO:0008150,GO:0008361,GO:0008381,GO:0009987,GO:0009992,GO:0015075,GO:0015267,GO:0015318,GO:0016020,GO:0016021,GO:0016043,GO:0019725,GO:0022803,GO:0022836,GO:0022838,GO:0022857,GO:0030104,GO:0031224,GO:0031226,GO:0032535,GO:0034220,GO:0042592,GO:0042802,GO:0044425,GO:0044459,GO:0044464,GO:0048878,GO:0051179,GO:0051234,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071840,GO:0071944,GO:0090066	-	ko:K03282	-	-	-	-	ko00000,ko02000	1.A.22.1	-	-	MscL
HKD2_k127_3700774_8	1167006.UWK_03494	4.391e-51	186.0	COG1704@1|root,COG1704@2|Bacteria,1MVH0@1224|Proteobacteria,42S15@68525|delta/epsilon subdivisions,2WNI1@28221|Deltaproteobacteria,2MNGZ@213118|Desulfobacterales	28221|Deltaproteobacteria	S	LemA family	-	-	-	ko:K03744	-	-	-	-	ko00000	-	-	-	LemA
HKD2_k127_3700774_1	1167006.UWK_03126	2.899e-129	421.0	COG2321@1|root,COG2321@2|Bacteria,1MU4U@1224|Proteobacteria,42N0U@68525|delta/epsilon subdivisions,2WJH3@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Putative neutral zinc metallopeptidase	-	-	-	ko:K07054	-	-	-	-	ko00000	-	-	-	Zn_peptidase
HKD2_k127_3700774_0	1121403.AUCV01000035_gene3778	2.463e-165	536.0	COG0826@1|root,COG0826@2|Bacteria,1MUQG@1224|Proteobacteria,42M8P@68525|delta/epsilon subdivisions,2WJZR@28221|Deltaproteobacteria,2MIY9@213118|Desulfobacterales	28221|Deltaproteobacteria	O	PFAM peptidase	-	-	-	ko:K08303	ko05120,map05120	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_U32,Peptidase_U32_C
HKD2_k127_3700774_6	867845.KI911784_gene1503	2.486e-72	263.0	COG1520@1|root,COG1520@2|Bacteria	2|Bacteria	S	amino acid activation for nonribosomal peptide biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	SBBP
HKD2_k127_3700774_3	243231.GSU1725	2.398e-84	283.0	COG0419@1|root,COG0419@2|Bacteria,1QKWB@1224|Proteobacteria,4377R@68525|delta/epsilon subdivisions,2WT00@28221|Deltaproteobacteria,43TVX@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	AAA domain	sbcC-2	-	-	ko:K03546	-	-	-	-	ko00000,ko03400	-	-	-	AAA_23
HKD2_k127_3730450_1	1121403.AUCV01000012_gene4065	3.224e-37	150.0	COG0457@1|root,COG0457@2|Bacteria	1121403.AUCV01000012_gene4065|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3730450_0	879212.DespoDRAFT_00856	1.532e-55	208.0	COG2304@1|root,COG2885@1|root,COG2304@2|Bacteria,COG2885@2|Bacteria,1R7WJ@1224|Proteobacteria,42QJK@68525|delta/epsilon subdivisions,2WJX0@28221|Deltaproteobacteria,2MIS0@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Belongs to the ompA family	-	-	-	ko:K03286	-	-	-	-	ko00000,ko02000	1.B.6	-	-	OmpA,TSP_3,VWA,VWA_2
HKD2_k127_3734503_1	589865.DaAHT2_0762	6.955e-154	498.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42PH1@68525|delta/epsilon subdivisions,2WKMX@28221|Deltaproteobacteria,2MJE1@213118|Desulfobacterales	28221|Deltaproteobacteria	T	PFAM sigma-54 factor interaction domain-containing protein	-	-	-	ko:K07714	ko02020,map02020	M00500	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD2_k127_3734503_2	589865.DaAHT2_0765	1.092e-41	174.0	COG5000@1|root,COG5000@2|Bacteria,1R13J@1224|Proteobacteria,43D5T@68525|delta/epsilon subdivisions,2X8CI@28221|Deltaproteobacteria,2MPMY@213118|Desulfobacterales	2|Bacteria	T	SMART ATP-binding region ATPase domain protein	-	-	2.7.13.3	ko:K07710	ko02020,map02020	M00500	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
HKD2_k127_3734503_0	635013.TherJR_2223	5.063e-308	972.0	COG1470@1|root,COG5276@1|root,COG1470@2|Bacteria,COG5276@2|Bacteria	2|Bacteria	S	cell adhesion involved in biofilm formation	-	-	-	ko:K12287	-	-	-	-	ko00000,ko02044	-	-	-	Big_5,CarboxypepD_reg,DUF1566,He_PIG,LVIVD,SLH
HKD2_k127_3735453_3	1121403.AUCV01000005_gene263	2.284e-58	205.0	COG1994@1|root,COG1994@2|Bacteria,1NSFF@1224|Proteobacteria,42STM@68525|delta/epsilon subdivisions,2WPAD@28221|Deltaproteobacteria,2MKSG@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Peptidase family M50	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M50
HKD2_k127_3735453_1	96561.Dole_1611	7.611e-74	255.0	292MF@1|root,2ZQ5C@2|Bacteria,1RCYR@1224|Proteobacteria,42RFG@68525|delta/epsilon subdivisions,2WPKN@28221|Deltaproteobacteria,2MK0P@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF3047)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3047
HKD2_k127_3735453_0	1121403.AUCV01000005_gene264	0.0	1233.0	COG0517@1|root,COG0617@1|root,COG0618@1|root,COG0517@2|Bacteria,COG0617@2|Bacteria,COG0618@2|Bacteria,1MU2X@1224|Proteobacteria,42MJJ@68525|delta/epsilon subdivisions,2WJBN@28221|Deltaproteobacteria,2MI4C@213118|Desulfobacterales	28221|Deltaproteobacteria	J	CBS domain	ccaA	-	2.7.7.72	ko:K00974	ko03013,map03013	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko00001,ko01000,ko03016	-	-	-	CBS,DHH,DHHA1,PolyA_pol,PolyA_pol_RNAbd
HKD2_k127_3735453_2	667014.Thein_0602	1.23e-72	250.0	COG0679@1|root,COG0679@2|Bacteria	2|Bacteria	S	auxin-activated signaling pathway	-	-	-	ko:K07088	-	-	-	-	ko00000	-	-	-	Mem_trans
HKD2_k127_3741551_1	1121403.AUCV01000010_gene1367	8.179e-92	327.0	COG2204@1|root,COG3852@1|root,COG2204@2|Bacteria,COG3852@2|Bacteria,1NTTH@1224|Proteobacteria,43BN0@68525|delta/epsilon subdivisions,2X702@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	ABC_sub_bind,HATPase_c,HisKA,PAS_4,PAS_9,Response_reg
HKD2_k127_3741551_0	1121403.AUCV01000010_gene1366	3.045e-149	485.0	COG0391@1|root,COG0391@2|Bacteria,1NW3K@1224|Proteobacteria,42NWF@68525|delta/epsilon subdivisions,2WJHB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Required for morphogenesis under gluconeogenic growth conditions	-	-	-	-	-	-	-	-	-	-	-	-	UPF0052
HKD2_k127_3789151_2	1163617.SCD_n01221	3.188e-06	52.0	COG0745@1|root,COG0745@2|Bacteria,1RDNP@1224|Proteobacteria,2VR8X@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Response regulator receiver	cheY	-	-	ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	Response_reg
HKD2_k127_3789151_1	1163617.SCD_n01222	2.915e-137	448.0	COG0784@1|root,COG0835@1|root,COG0784@2|Bacteria,COG0835@2|Bacteria,1N81M@1224|Proteobacteria,2VI4E@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Response regulator receiver	cheV1-2	-	-	ko:K03415	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	CheW,Response_reg
HKD2_k127_3789151_0	1163617.SCD_n01223	2.087e-142	459.0	COG0784@1|root,COG0835@1|root,COG0784@2|Bacteria,COG0835@2|Bacteria,1N81M@1224|Proteobacteria,2VI4E@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Response regulator receiver	cheV	-	-	ko:K03415	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	CheW,Response_reg
HKD2_k127_378934_0	1121403.AUCV01000010_gene1336	3.583e-68	236.0	COG0163@1|root,COG0163@2|Bacteria,1RA0P@1224|Proteobacteria,42QXP@68525|delta/epsilon subdivisions,2WP9I@28221|Deltaproteobacteria,2MJY8@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN	ubiX	-	2.5.1.129	ko:K03186	ko00130,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00627,map00940,map01100,map01110,map01120,map01220	M00117	R01238,R02952,R03367,R04985,R04986,R11225	RC00391,RC00814,RC03392	ko00000,ko00001,ko00002,ko01000	-	-	-	Flavoprotein
HKD2_k127_378934_1	1499967.BAYZ01000158_gene450	2.562e-29	124.0	COG1352@1|root,COG1871@1|root,COG1352@2|Bacteria,COG1871@2|Bacteria,2NQU2@2323|unclassified Bacteria	2|Bacteria	NT	Methyltransferase, chemotaxis proteins	cheD	-	2.1.1.80,3.1.1.61,3.5.1.44	ko:K00575,ko:K03411,ko:K03412	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheD,CheR,CheR_N
HKD2_k127_378934_2	1121403.AUCV01000025_gene2296	0.0005125	48.0	2ESCT@1|root,33JXK@2|Bacteria,1NK92@1224|Proteobacteria,42Y2H@68525|delta/epsilon subdivisions,2WSPA@28221|Deltaproteobacteria,2MM9Z@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3804232_0	1167006.UWK_02869	1.45e-150	501.0	COG0784@1|root,COG3852@1|root,COG0784@2|Bacteria,COG3852@2|Bacteria,1NC9X@1224|Proteobacteria,43BSJ@68525|delta/epsilon subdivisions,2X73B@28221|Deltaproteobacteria,2MI6A@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_9,Response_reg
HKD2_k127_3804232_3	269799.Gmet_3455	1.316e-17	98.0	COG4251@1|root,COG4251@2|Bacteria,1NSQ1@1224|Proteobacteria	1224|Proteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_9,Response_reg,dCache_1
HKD2_k127_3804232_2	243231.GSU1054	8.983e-18	88.0	COG0425@1|root,COG0425@2|Bacteria	2|Bacteria	O	sulfur carrier activity	tusA-2	GO:0008150,GO:0009987,GO:0019725,GO:0042592,GO:0048878,GO:0055082,GO:0065007,GO:0065008	-	ko:K07112	-	-	-	-	ko00000	-	-	-	HTH_20,HTH_5,TusA
HKD2_k127_3804232_1	589865.DaAHT2_2625	1.104e-122	403.0	COG2391@1|root,COG2391@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K07112	-	-	-	-	ko00000	-	-	-	Sulf_transp
HKD2_k127_3817864_6	1121403.AUCV01000008_gene1504	6.305e-113	366.0	COG0472@1|root,COG0472@2|Bacteria,1MUTK@1224|Proteobacteria,42MCP@68525|delta/epsilon subdivisions,2WJDS@28221|Deltaproteobacteria,2MHYY@213118|Desulfobacterales	28221|Deltaproteobacteria	M	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan	mraY	-	2.7.8.13	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	-	R05629,R05630	RC00002,RC02753	ko00000,ko00001,ko01000,ko01011	9.B.146	-	iAF987.Gmet_0409	Glycos_transf_4,MraY_sig1
HKD2_k127_3817864_5	1121403.AUCV01000008_gene1505	3.977e-129	426.0	COG0771@1|root,COG0771@2|Bacteria,1MVYD@1224|Proteobacteria,42MJY@68525|delta/epsilon subdivisions,2WJAQ@28221|Deltaproteobacteria,2MHTV@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)	murD	-	6.3.2.9	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R02783	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	AlaDh_PNT_C,FAD_binding_3,Mur_ligase_C,Mur_ligase_M,NAD_binding_8
HKD2_k127_3817864_7	1167006.UWK_03486	4.782e-105	352.0	COG0707@1|root,COG0707@2|Bacteria,1MVIB@1224|Proteobacteria,42ME1@68525|delta/epsilon subdivisions,2WJNY@28221|Deltaproteobacteria,2MHZT@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)	murG	-	2.4.1.227	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	-	R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011	-	GT28	-	Glyco_tran_28_C,Glyco_transf_28
HKD2_k127_3817864_2	1121403.AUCV01000008_gene1508	1.118e-205	649.0	COG0773@1|root,COG0773@2|Bacteria,1MV68@1224|Proteobacteria,42MMP@68525|delta/epsilon subdivisions,2WK50@28221|Deltaproteobacteria,2MIR1@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Belongs to the MurCDEF family	murC	-	6.3.2.8	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R03193	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
HKD2_k127_3817864_8	1167006.UWK_03484	4.134e-73	274.0	COG0812@1|root,COG0812@2|Bacteria,1MXDH@1224|Proteobacteria,42P86@68525|delta/epsilon subdivisions,2WN8T@28221|Deltaproteobacteria,2MJWP@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Cell wall formation	murB	-	1.3.1.98	ko:K00075	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R03191,R03192	RC02639	ko00000,ko00001,ko01000,ko01011	-	-	-	FAD_binding_4,MurB_C
HKD2_k127_3817864_10	1121403.AUCV01000008_gene1510	1.372e-49	189.0	COG1589@1|root,COG1589@2|Bacteria,1RDX7@1224|Proteobacteria,42VCZ@68525|delta/epsilon subdivisions,2WRVM@28221|Deltaproteobacteria	28221|Deltaproteobacteria	D	Essential cell division protein	ftsQ	-	-	ko:K03589	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036	-	-	-	FtsQ,POTRA_1
HKD2_k127_3817864_1	1121403.AUCV01000008_gene1511	6.054e-209	655.0	COG0849@1|root,COG0849@2|Bacteria,1MUSR@1224|Proteobacteria,42MS2@68525|delta/epsilon subdivisions,2WIQ0@28221|Deltaproteobacteria,2MHV9@213118|Desulfobacterales	28221|Deltaproteobacteria	D	Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring	ftsA	-	-	ko:K03590	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036,ko04812	-	-	-	FtsA,SHS2_FTSA
HKD2_k127_3817864_3	1121403.AUCV01000008_gene1512	6.165e-182	576.0	COG0206@1|root,COG0206@2|Bacteria,1MV2X@1224|Proteobacteria,42MHK@68525|delta/epsilon subdivisions,2WJAZ@28221|Deltaproteobacteria,2MHTR@213118|Desulfobacterales	28221|Deltaproteobacteria	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
HKD2_k127_3817864_0	1121403.AUCV01000008_gene1513	4.339e-217	688.0	COG1032@1|root,COG1032@2|Bacteria,1MU15@1224|Proteobacteria,42N12@68525|delta/epsilon subdivisions,2WK0X@28221|Deltaproteobacteria,2MI8S@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
HKD2_k127_3817864_4	1121403.AUCV01000008_gene1514	7.293e-167	541.0	COG3852@1|root,COG3852@2|Bacteria,1MVN6@1224|Proteobacteria,43BPS@68525|delta/epsilon subdivisions,2X710@28221|Deltaproteobacteria,2MPN4@213118|Desulfobacterales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
HKD2_k127_3817864_9	1121403.AUCV01000008_gene1518	8.563e-60	236.0	COG2982@1|root,COG2982@2|Bacteria	2|Bacteria	M	Protein involved in outer membrane biogenesis	CP_0578	-	-	-	-	-	-	-	-	-	-	-	AsmA_2
HKD2_k127_3841165_16	1167006.UWK_02846	3.107e-34	136.0	2E8HY@1|root,332W0@2|Bacteria,1N9SS@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3841165_5	357808.RoseRS_3371	5.611e-125	421.0	COG3437@1|root,COG5002@1|root,COG3437@2|Bacteria,COG5002@2|Bacteria,2GBI7@200795|Chloroflexi,376P2@32061|Chloroflexia	32061|Chloroflexia	T	metal-dependent phosphohydrolase, HD sub domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HD,HD_5,PAS,Response_reg
HKD2_k127_3841165_7	1121403.AUCV01000004_gene2026	4.496e-101	337.0	COG1989@1|root,COG1989@2|Bacteria,1MUZF@1224|Proteobacteria,42S2A@68525|delta/epsilon subdivisions,2WMQ8@28221|Deltaproteobacteria,2MJAD@213118|Desulfobacterales	28221|Deltaproteobacteria	NOU	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue	pilD	-	3.4.23.43	ko:K02654	-	M00331	-	-	ko00000,ko00002,ko01000,ko01002,ko02035,ko02044	3.A.15.2	-	-	DiS_P_DiS,Peptidase_A24
HKD2_k127_3841165_8	1121403.AUCV01000004_gene2027	1.588e-90	306.0	COG0543@1|root,COG0543@2|Bacteria,1RF43@1224|Proteobacteria,42RQK@68525|delta/epsilon subdivisions,2WNJU@28221|Deltaproteobacteria,2MKD4@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(	pyrK	-	-	ko:K02823	ko00240,ko01100,map00240,map01100	-	-	-	ko00000,ko00001	-	-	-	DHODB_Fe-S_bind,FAD_binding_6,NAD_binding_1
HKD2_k127_3841165_4	1167006.UWK_00234	2.097e-129	424.0	COG0167@1|root,COG0167@2|Bacteria,1MU7C@1224|Proteobacteria,42M46@68525|delta/epsilon subdivisions,2WJ7G@28221|Deltaproteobacteria,2MIHH@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily	pyrD	GO:0003674,GO:0003824,GO:0004152,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016627,GO:0016635,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019856,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046112,GO:0046390,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	1.3.1.14,1.3.5.2	ko:K00254,ko:K02823,ko:K17828	ko00240,ko01100,map00240,map01100	M00051	R01868,R01869	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
HKD2_k127_3841165_14	1121403.AUCV01000004_gene2029	1.571e-52	194.0	COG0710@1|root,COG0710@2|Bacteria,1NG0G@1224|Proteobacteria,42W3S@68525|delta/epsilon subdivisions,2WRJE@28221|Deltaproteobacteria,2MP55@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3- dehydroshikimate	aroD	-	4.2.1.10	ko:K03785	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03084	RC00848	ko00000,ko00001,ko00002,ko01000	-	-	-	DHquinase_I
HKD2_k127_3841165_11	331678.Cphamn1_1620	5.637e-68	235.0	COG2077@1|root,COG2077@2|Bacteria,1FDXA@1090|Chlorobi	1090|Chlorobi	O	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides	tpx	-	1.11.1.15	ko:K11065	-	-	-	-	ko00000,ko01000	-	-	-	Redoxin
HKD2_k127_3841165_13	1304885.AUEY01000007_gene1357	5.866e-55	204.0	COG2202@1|root,COG2905@1|root,COG4564@1|root,COG2202@2|Bacteria,COG2905@2|Bacteria,COG4564@2|Bacteria,1MW8U@1224|Proteobacteria,42NAX@68525|delta/epsilon subdivisions,2WJF5@28221|Deltaproteobacteria,2MIA9@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Putative nucleotidyltransferase substrate binding domain	-	-	-	ko:K07182	-	-	-	-	ko00000	-	-	-	CBS,DUF294,DUF294_C,PAS_8,cNMP_binding,sCache_2
HKD2_k127_3841165_17	1121403.AUCV01000003_gene1738	2.103e-24	114.0	COG4191@1|root,COG5000@1|root,COG4191@2|Bacteria,COG5000@2|Bacteria,1R2HC@1224|Proteobacteria,42VJW@68525|delta/epsilon subdivisions,2WR7V@28221|Deltaproteobacteria,2MPPK@213118|Desulfobacterales	28221|Deltaproteobacteria	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3841165_10	1499967.BAYZ01000038_gene2272	9.33e-74	258.0	COG2981@1|root,COG2981@2|Bacteria	2|Bacteria	E	high-affinity sulfate:proton symporter activity	cysZ	GO:0000096,GO:0000097,GO:0000103,GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006082,GO:0006520,GO:0006534,GO:0006790,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0008150,GO:0008152,GO:0008271,GO:0008272,GO:0008324,GO:0008509,GO:0008512,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009675,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015103,GO:0015116,GO:0015291,GO:0015293,GO:0015294,GO:0015295,GO:0015296,GO:0015318,GO:0015672,GO:0015698,GO:0016020,GO:0016021,GO:0016053,GO:0019344,GO:0019752,GO:0022804,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0034220,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044425,GO:0044459,GO:0044464,GO:0046394,GO:0051179,GO:0051234,GO:0055085,GO:0071704,GO:0071944,GO:0072348,GO:0098655,GO:0098656,GO:0098660,GO:0098661,GO:0098662,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901682,GO:1902358,GO:1902600	-	ko:K06203	-	-	-	-	ko00000	-	-	iJR904.b2413,iYL1228.KPN_02760	EI24
HKD2_k127_3841165_12	1167006.UWK_03296	1.233e-61	216.0	COG1499@1|root,COG1499@2|Bacteria,1N5GB@1224|Proteobacteria,42THG@68525|delta/epsilon subdivisions,2WQ5E@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	ribosomal large subunit export from nucleus	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3841165_15	935863.AWZR01000013_gene1473	4.855e-36	141.0	COG0818@1|root,COG0818@2|Bacteria,1MZ3Q@1224|Proteobacteria,1S92I@1236|Gammaproteobacteria,1X70R@135614|Xanthomonadales	135614|Xanthomonadales	M	Recycling of diacylglycerol produced during the turnover of membrane phospholipid	dgkA	-	2.7.1.107	ko:K00901	ko00561,ko00564,ko01100,ko01110,ko04070,ko04072,ko05231,map00561,map00564,map01100,map01110,map04070,map04072,map05231	-	R02240	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	DAGK_prokar
HKD2_k127_3841165_1	384676.PSEEN2945	2.156e-164	541.0	COG1368@1|root,COG1368@2|Bacteria,1MVCM@1224|Proteobacteria,1RNJ3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily	mdoB	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006490,GO:0006629,GO:0008150,GO:0008152,GO:0008960,GO:0009058,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016780,GO:0042597,GO:0044237,GO:0044238,GO:0044255,GO:0044464,GO:0071704,GO:0071944,GO:1901135,GO:1901137,GO:1901576	2.7.8.20	ko:K01002	ko01100,map01100	-	-	-	ko00000,ko01000	-	-	-	Sulfatase
HKD2_k127_3841165_0	1121403.AUCV01000021_gene3579	3.751e-191	602.0	COG2021@1|root,COG2021@2|Bacteria,1MVJV@1224|Proteobacteria,42N1M@68525|delta/epsilon subdivisions,2WJRJ@28221|Deltaproteobacteria,2MIEA@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine	metXA	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004414,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008374,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009092,GO:0009987,GO:0016053,GO:0016407,GO:0016413,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.3.1.31	ko:K00641	ko00270,ko01100,ko01130,map00270,map01100,map01130	-	R01776	RC00004,RC00041	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1,Homoserine_dh,NAD_binding_3
HKD2_k127_3841165_9	1121403.AUCV01000021_gene3578	2.76e-83	288.0	COG0500@1|root,COG2226@2|Bacteria,1MVSY@1224|Proteobacteria,42QRQ@68525|delta/epsilon subdivisions,2WMRU@28221|Deltaproteobacteria,2MJP2@213118|Desulfobacterales	28221|Deltaproteobacteria	Q	TIGRFAM methionine biosynthesis protein MetW	-	-	-	-	-	-	-	-	-	-	-	-	MetW
HKD2_k127_3841165_3	1121403.AUCV01000021_gene3577	6.181e-132	428.0	COG1045@1|root,COG1045@2|Bacteria,1MVFX@1224|Proteobacteria,42MND@68525|delta/epsilon subdivisions,2WJC3@28221|Deltaproteobacteria,2MIG5@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Bacterial transferase hexapeptide (six repeats)	cysE	-	2.3.1.30	ko:K00640	ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111	M00021	R00586	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,SATase_N
HKD2_k127_3841165_6	247490.KSU1_C0520	4.044e-121	396.0	COG0031@1|root,COG0031@2|Bacteria,2IXCX@203682|Planctomycetes	203682|Planctomycetes	E	cysteine synthase	-	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HKD2_k127_3841165_2	589865.DaAHT2_2377	5.8e-137	440.0	COG2873@1|root,COG2873@2|Bacteria,1NQME@1224|Proteobacteria,43DRR@68525|delta/epsilon subdivisions,2X70U@28221|Deltaproteobacteria,2MJ6E@213118|Desulfobacterales	28221|Deltaproteobacteria	E	PFAM Cys Met metabolism	metY-1	-	2.5.1.49	ko:K01740	ko00270,ko01100,map00270,map01100	-	R01287,R04859	RC00020,RC02821,RC02848	ko00000,ko00001,ko01000	-	-	-	Cys_Met_Meta_PP
HKD2_k127_3841165_21	432096.XP_003958038.1	0.0002392	48.0	COG0626@1|root,KOG0053@2759|Eukaryota,38F3Q@33154|Opisthokonta,3NVTU@4751|Fungi,3QPPV@4890|Ascomycota,3RSN8@4891|Saccharomycetes,3S0V2@4893|Saccharomycetaceae	4751|Fungi	E	to Saccharomyces cerevisiae MET17 (YLR303W)	MET15	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0003961,GO:0004124,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006555,GO:0006563,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009070,GO:0009086,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016765,GO:0017144,GO:0019344,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0050667,GO:0071265,GO:0071266,GO:0071268,GO:0071269,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.5.1.47,2.5.1.49	ko:K17069	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	Cys_Met_Meta_PP
HKD2_k127_3868416_1	1121403.AUCV01000020_gene3143	3.231e-25	113.0	COG3266@1|root,COG3267@1|root,COG3266@2|Bacteria,COG3267@2|Bacteria,1MU3G@1224|Proteobacteria	1224|Proteobacteria	U	Type II secretory pathway component ExeA	exeA1	-	-	ko:K12283	-	-	-	-	ko00000,ko02044	-	-	-	AAA_22,SPOR
HKD2_k127_3868416_0	1167006.UWK_00962	1.729e-92	310.0	COG0778@1|root,COG1146@1|root,COG0778@2|Bacteria,COG1146@2|Bacteria,1MY8Z@1224|Proteobacteria,42Q5E@68525|delta/epsilon subdivisions,2WJES@28221|Deltaproteobacteria,2MPXK@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_4,Fer4_9,Nitroreductase
HKD2_k127_3886418_7	1444309.JAQG01000106_gene1049	2.863e-09	58.0	COG0147@1|root,COG0147@2|Bacteria,1TQAP@1239|Firmicutes,4HB31@91061|Bacilli,26QK1@186822|Paenibacillaceae	91061|Bacilli	E	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia	trpE	GO:0000162,GO:0003674,GO:0003824,GO:0004049,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005950,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016829,GO:0016830,GO:0016833,GO:0018130,GO:0019438,GO:0019752,GO:0032991,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494	4.1.3.27	ko:K01657	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
HKD2_k127_3886418_2	926569.ANT_05940	1.916e-73	268.0	COG0512@1|root,COG0512@2|Bacteria,2G69G@200795|Chloroflexi	200795|Chloroflexi	EH	TIGRFAM glutamine amidotransferase of anthranilate synthase	trpG	-	4.1.3.27	ko:K01658	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
HKD2_k127_3886418_0	926569.ANT_05930	3.051e-137	454.0	COG0547@1|root,COG0547@2|Bacteria,2G5YV@200795|Chloroflexi	200795|Chloroflexi	F	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)	trpD	GO:0000162,GO:0003674,GO:0003824,GO:0004048,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.4.2.18	ko:K00766	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R01073	RC00440	ko00000,ko00001,ko00002,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3
HKD2_k127_3886418_3	72664.XP_006418574.1	4.34e-62	224.0	COG0134@1|root,KOG4201@2759|Eukaryota,37PA6@33090|Viridiplantae,3GDJN@35493|Streptophyta,3HZ10@3699|Brassicales	35493|Streptophyta	E	Indole-3-glycerol phosphate synthase	-	GO:0000162,GO:0003674,GO:0003824,GO:0004425,GO:0005488,GO:0005507,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0009987,GO:0016053,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.1.1.48	ko:K01609	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03508	RC00944	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPS
HKD2_k127_3886418_1	96561.Dole_1380	7.706e-92	309.0	COG3910@1|root,COG3910@2|Bacteria,1MZSY@1224|Proteobacteria,42R25@68525|delta/epsilon subdivisions,2WN2C@28221|Deltaproteobacteria,2MJIF@213118|Desulfobacterales	28221|Deltaproteobacteria	S	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	-	-	-	-	-	-	-	-	-	AAA_21,AAA_23
HKD2_k127_3886418_4	926569.ANT_05910	3.837e-43	174.0	COG0135@1|root,COG0135@2|Bacteria,2G6QB@200795|Chloroflexi	200795|Chloroflexi	E	Belongs to the TrpF family	trpF	-	5.3.1.24	ko:K01817	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03509	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	PRAI
HKD2_k127_3886418_6	1122918.KB907291_gene4261	5.15e-17	82.0	COG0454@1|root,COG2318@1|root,COG0456@2|Bacteria,COG2318@2|Bacteria,1V4QC@1239|Firmicutes,4HN2T@91061|Bacilli,26Z4F@186822|Paenibacillaceae	91061|Bacilli	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_10
HKD2_k127_3886418_5	1121468.AUBR01000014_gene2228	2.549e-27	113.0	COG0133@1|root,COG0133@2|Bacteria,1TPI3@1239|Firmicutes,24881@186801|Clostridia,42EWK@68295|Thermoanaerobacterales	186801|Clostridia	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB	-	4.2.1.20	ko:K01696	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HKD2_k127_3891705_0	1121403.AUCV01000002_gene576	9.336e-279	868.0	COG0188@1|root,COG0188@2|Bacteria,1MUGG@1224|Proteobacteria,42KZ9@68525|delta/epsilon subdivisions,2WJBC@28221|Deltaproteobacteria,2MIKT@213118|Desulfobacterales	28221|Deltaproteobacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	-	-	-	ko:K02621	-	-	-	-	ko00000,ko01000,ko02048,ko03032,ko03036	-	-	-	DNA_topoisoIV
HKD2_k127_3891705_1	589865.DaAHT2_0804	2.014e-92	308.0	COG1387@1|root,COG1387@2|Bacteria,1R9W5@1224|Proteobacteria,42QNF@68525|delta/epsilon subdivisions,2WMV0@28221|Deltaproteobacteria,2MJIA@213118|Desulfobacterales	28221|Deltaproteobacteria	E	SMART phosphoesterase PHP domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PHP
HKD2_k127_3891705_2	1121403.AUCV01000002_gene521	8.097e-59	208.0	COG0621@1|root,COG0621@2|Bacteria,1MURS@1224|Proteobacteria,42MQ3@68525|delta/epsilon subdivisions,2WJEE@28221|Deltaproteobacteria,2MHM5@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine	miaB	-	2.8.4.3	ko:K06168	-	-	R10645,R10646,R10647	RC00003,RC00980,RC03221,RC03222	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
HKD2_k127_3902745_7	1182590.BN5_01341	1.818e-76	263.0	COG0604@1|root,COG0604@2|Bacteria,1MV3W@1224|Proteobacteria,1RMHG@1236|Gammaproteobacteria,1YE3R@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	C	Alcohol dehydrogenase GroES-like domain	yhfP	-	1.1.1.1	ko:K00001,ko:K19745	ko00010,ko00071,ko00350,ko00625,ko00626,ko00640,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00640,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R00919,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00095,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
HKD2_k127_3902745_8	1121403.AUCV01000005_gene304	4.339e-40	159.0	COG0340@1|root,COG0340@2|Bacteria	2|Bacteria	H	biotin-[acetyl-CoA-carboxylase] ligase activity	birA	-	6.3.4.15	ko:K03524	ko00780,ko01100,map00780,map01100	-	R01074,R05145	RC00043,RC00070,RC00096,RC02896	ko00000,ko00001,ko01000,ko03000	-	-	-	BPL_C,BPL_LplA_LipB,HTH_11
HKD2_k127_3902745_9	1167006.UWK_01635	6.072e-30	121.0	2DS67@1|root,33ER5@2|Bacteria,1R3JK@1224|Proteobacteria,43DKG@68525|delta/epsilon subdivisions,2X8RN@28221|Deltaproteobacteria,2MPQK@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Dissimilatory sulfite reductase D (DsrD)	-	-	-	-	-	-	-	-	-	-	-	-	DsrD
HKD2_k127_3902745_2	177439.DP0798	1.685e-218	681.0	COG2221@1|root,COG2221@2|Bacteria,1MVZQ@1224|Proteobacteria,42N7B@68525|delta/epsilon subdivisions,2WJYE@28221|Deltaproteobacteria,2MI4D@213118|Desulfobacterales	28221|Deltaproteobacteria	C	TIGRFAM sulfite reductase, dissimilatory-type beta subunit	dsrB	-	1.8.99.5	ko:K11181	ko00633,ko00920,ko01100,ko01120,map00633,map00920,map01100,map01120	M00596	R00295,R00861,R08035	RC00065,RC01760	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_7,NIR_SIR,NIR_SIR_ferr
HKD2_k127_3902745_0	1121403.AUCV01000005_gene301	4.972e-260	803.0	COG2221@1|root,COG2221@2|Bacteria,1MWY5@1224|Proteobacteria,42MRB@68525|delta/epsilon subdivisions,2WIZD@28221|Deltaproteobacteria,2MIFB@213118|Desulfobacterales	28221|Deltaproteobacteria	C	TIGRFAM sulfite reductase, dissimilatory-type alpha subunit	dsrA	-	1.8.99.5	ko:K11180	ko00633,ko00920,ko01100,ko01120,map00633,map00920,map01100,map01120	M00596	R00295,R00861,R08035	RC00065,RC01760	ko00000,ko00001,ko00002,ko01000	-	-	-	NIR_SIR,NIR_SIR_ferr
HKD2_k127_3902745_1	1121403.AUCV01000005_gene300	1.254e-225	709.0	COG0166@1|root,COG0166@2|Bacteria,1MUFP@1224|Proteobacteria,42MNB@68525|delta/epsilon subdivisions,2WJ0I@28221|Deltaproteobacteria,2MIAG@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Belongs to the GPI family	pgi	-	5.3.1.9	ko:K01810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114	R02739,R02740,R03321	RC00376,RC00563	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGI
HKD2_k127_3902745_5	1121403.AUCV01000005_gene299	2.145e-97	324.0	COG0036@1|root,COG0036@2|Bacteria,1MUZM@1224|Proteobacteria,42NC0@68525|delta/epsilon subdivisions,2WJK9@28221|Deltaproteobacteria,2MHRY@213118|Desulfobacterales	28221|Deltaproteobacteria	G	Belongs to the ribulose-phosphate 3-epimerase family	rpe	-	5.1.3.1	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
HKD2_k127_3902745_6	1167006.UWK_01630	2.655e-93	319.0	COG0758@1|root,COG0758@2|Bacteria,1MVF6@1224|Proteobacteria,42N10@68525|delta/epsilon subdivisions,2WJI9@28221|Deltaproteobacteria,2MHSD@213118|Desulfobacterales	28221|Deltaproteobacteria	LU	TIGRFAM DNA protecting protein DprA	dprA	-	-	ko:K04096	-	-	-	-	ko00000	-	-	-	DNA_processg_A,HHH_5
HKD2_k127_3902745_4	1167006.UWK_01629	4.562e-158	516.0	COG0568@1|root,COG0568@2|Bacteria,1MVNJ@1224|Proteobacteria,42N2S@68525|delta/epsilon subdivisions,2WJ0E@28221|Deltaproteobacteria,2MHX2@213118|Desulfobacterales	28221|Deltaproteobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	rpoD	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_ner,Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
HKD2_k127_3902745_3	1121403.AUCV01000005_gene296	2.994e-186	600.0	COG0358@1|root,COG0358@2|Bacteria,1MUHC@1224|Proteobacteria,42MDZ@68525|delta/epsilon subdivisions,2WJ9Y@28221|Deltaproteobacteria,2MHRW@213118|Desulfobacterales	28221|Deltaproteobacteria	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2
HKD2_k127_3902745_10	1121403.AUCV01000005_gene295	3.597e-07	53.0	2EB4X@1|root,3355K@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3904661_0	941449.dsx2_2185	4.401e-129	421.0	COG1008@1|root,COG1008@2|Bacteria,1MV7V@1224|Proteobacteria,42MBQ@68525|delta/epsilon subdivisions,2X5HD@28221|Deltaproteobacteria,2M90X@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	NADH-quinone oxidoreductase, chain M	nuoM-2	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
HKD2_k127_3904661_1	941449.dsx2_2186	2.427e-33	140.0	COG1007@1|root,COG1007@2|Bacteria,1MV56@1224|Proteobacteria,42QMR@68525|delta/epsilon subdivisions,2WJSY@28221|Deltaproteobacteria,2M9EA@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoN-2	-	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	iAF987.Gmet_0172	Proton_antipo_M
HKD2_k127_3944444_5	1210884.HG799468_gene13578	2.319e-38	149.0	COG2201@1|root,COG2201@2|Bacteria,2IX6F@203682|Planctomycetes	203682|Planctomycetes	NT	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR	cheB	-	3.1.1.61,3.5.1.44	ko:K03412	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest,Response_reg
HKD2_k127_3944444_6	1123242.JH636434_gene5115	1.245e-30	127.0	COG0835@1|root,COG0835@2|Bacteria,2J3QK@203682|Planctomycetes	203682|Planctomycetes	NT	Two component signalling adaptor domain	-	-	-	-	-	-	-	-	-	-	-	-	CheW
HKD2_k127_3944444_0	1210884.HG799468_gene13575	3.54e-207	674.0	COG0643@1|root,COG0643@2|Bacteria,2IWWG@203682|Planctomycetes	203682|Planctomycetes	T	Signal transducing histidine kinase, homodimeric	-	-	-	ko:K02487,ko:K06596	ko02020,ko02025,map02020,map02025	M00507	-	-	ko00000,ko00001,ko00002,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg
HKD2_k127_3944444_2	439235.Dalk_2490	1.921e-49	187.0	COG0745@1|root,COG2018@1|root,COG0745@2|Bacteria,COG2018@2|Bacteria,1RIGT@1224|Proteobacteria,42SWP@68525|delta/epsilon subdivisions,2WPJ3@28221|Deltaproteobacteria,2MK4B@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Domain of unknown function (DUF4388)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4388,Response_reg
HKD2_k127_3944444_4	96561.Dole_0049	6.931e-42	162.0	COG2204@1|root,COG2204@2|Bacteria	2|Bacteria	T	phosphorelay signal transduction system	-	-	-	ko:K13599	ko02020,map02020	M00498	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	DUF4388,HATPase_c,HTH_8,HisKA,Response_reg,SSF,Sigma54_activat
HKD2_k127_3944444_8	425400.LS65_06465	2.006e-19	103.0	COG0643@1|root,COG0643@2|Bacteria,1MUAG@1224|Proteobacteria,42M6Q@68525|delta/epsilon subdivisions,2YMB9@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	T	chemotaxis protein	cheA	-	2.7.13.3	ko:K03407	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg
HKD2_k127_3944444_7	1298593.TOL_2511	1.875e-28	118.0	COG0745@1|root,COG0745@2|Bacteria,1RHDD@1224|Proteobacteria,1S67R@1236|Gammaproteobacteria,1XK82@135619|Oceanospirillales	135619|Oceanospirillales	T	cheY-homologous receiver domain	-	-	-	ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	Response_reg
HKD2_k127_3944444_3	196162.Noca_2984	1.344e-45	186.0	COG0840@1|root,COG0840@2|Bacteria,2GP45@201174|Actinobacteria	201174|Actinobacteria	NT	methyl-accepting chemotaxis protein	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	4HB_MCP_1,HAMP,MCPsignal
HKD2_k127_3944444_1	156889.Mmc1_1584	1.073e-75	265.0	COG0226@1|root,COG0226@2|Bacteria	2|Bacteria	P	phosphate ion binding	sphX	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
HKD2_k127_3945087_8	1121403.AUCV01000008_gene1652	2.94e-85	297.0	COG2027@1|root,COG2027@2|Bacteria,1MW40@1224|Proteobacteria,42R96@68525|delta/epsilon subdivisions,2WMVV@28221|Deltaproteobacteria,2MHT9@213118|Desulfobacterales	28221|Deltaproteobacteria	M	PFAM peptidase S13 D-Ala-D-Ala carboxypeptidase C	dacB	-	3.4.16.4	ko:K07259	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	Peptidase_S13
HKD2_k127_3945087_1	1167006.UWK_03366	1.511e-234	732.0	COG1350@1|root,COG1350@2|Bacteria,1N07Y@1224|Proteobacteria,42MPB@68525|delta/epsilon subdivisions,2WJUV@28221|Deltaproteobacteria,2MJ5P@213118|Desulfobacterales	28221|Deltaproteobacteria	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB2	-	4.2.1.20	ko:K06001	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HKD2_k127_3945087_0	1121403.AUCV01000008_gene1651	1.015e-308	967.0	COG1032@1|root,COG5011@1|root,COG1032@2|Bacteria,COG5011@2|Bacteria,1MV5G@1224|Proteobacteria,42MPT@68525|delta/epsilon subdivisions,2WJG9@28221|Deltaproteobacteria,2MHW1@213118|Desulfobacterales	28221|Deltaproteobacteria	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	DUF2344,Radical_SAM
HKD2_k127_3945087_12	1121403.AUCV01000008_gene1650	9.069e-49	189.0	COG3170@1|root,COG3170@2|Bacteria	2|Bacteria	NU	translation initiation factor activity	-	-	-	ko:K02237,ko:K03497,ko:K12065	-	M00429	-	-	ko00000,ko00002,ko02044,ko03000,ko03036,ko04812	3.A.11.1,3.A.11.2,3.A.7.11.1	-	-	-
HKD2_k127_3945087_10	1121403.AUCV01000003_gene1864	6.816e-58	203.0	COG0789@1|root,COG0789@2|Bacteria,1N948@1224|Proteobacteria,42SGY@68525|delta/epsilon subdivisions,2WSXW@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	helix_turn_helix, mercury resistance	-	-	-	ko:K13640	-	-	-	-	ko00000,ko03000	-	-	-	MerR_1
HKD2_k127_3945087_5	1121403.AUCV01000003_gene1863	2.446e-157	506.0	COG5557@1|root,COG5557@2|Bacteria,1R54P@1224|Proteobacteria,42N9S@68525|delta/epsilon subdivisions,2WNKD@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM Polysulphide reductase, NrfD	-	-	-	ko:K00185	-	-	-	-	ko00000	5.A.3	-	-	NrfD
HKD2_k127_3945087_9	1121403.AUCV01000003_gene1862	4.379e-64	227.0	COG3005@1|root,COG3005@2|Bacteria	2|Bacteria	C	denitrification pathway	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C7,Paired_CXXCH_1
HKD2_k127_3945087_6	1121403.AUCV01000003_gene1861	7.577e-131	422.0	COG0437@1|root,COG0437@2|Bacteria,1NBNQ@1224|Proteobacteria,43AQ8@68525|delta/epsilon subdivisions,2X642@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM 4Fe-4S dicluster domain	-	-	-	ko:K04014	-	-	-	-	ko00000	-	-	-	Fer4_11,Fer4_3
HKD2_k127_3945087_4	1121403.AUCV01000003_gene1860	7.512e-195	623.0	COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,42MFH@68525|delta/epsilon subdivisions,2WIRW@28221|Deltaproteobacteria,2MIJ9@213118|Desulfobacterales	28221|Deltaproteobacteria	KT	Bacterial regulatory protein, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,PAS,PAS_4,PAS_9,Sigma54_activat
HKD2_k127_3945087_11	1121403.AUCV01000003_gene1859	1.308e-54	197.0	COG0789@1|root,COG0789@2|Bacteria,1N948@1224|Proteobacteria,42SGY@68525|delta/epsilon subdivisions,2WSXW@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	helix_turn_helix, mercury resistance	-	-	-	ko:K13640	-	-	-	-	ko00000,ko03000	-	-	-	MerR_1
HKD2_k127_3945087_3	1121403.AUCV01000003_gene1858	7.777e-212	663.0	COG5557@1|root,COG5557@2|Bacteria,1R54P@1224|Proteobacteria,42N9S@68525|delta/epsilon subdivisions,2WNKD@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM Polysulphide reductase, NrfD	-	-	-	ko:K00185	-	-	-	-	ko00000	5.A.3	-	-	NrfD
HKD2_k127_3945087_2	589865.DaAHT2_0902	4.004e-229	728.0	COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,42M4Z@68525|delta/epsilon subdivisions,2WJ0D@28221|Deltaproteobacteria,2MIPH@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
HKD2_k127_3945087_7	1121403.AUCV01000003_gene1856	2.244e-116	392.0	28I8B@1|root,2Z8B5@2|Bacteria,1MUNM@1224|Proteobacteria,42NZH@68525|delta/epsilon subdivisions,2WKHB@28221|Deltaproteobacteria,2MISZ@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM Cytochrome c, bacterial	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_CIII,Cytochrome_C554,Cytochrome_C7,Cytochrome_cB
HKD2_k127_3952699_0	398767.Glov_1114	1.98e-163	529.0	COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,42M1X@68525|delta/epsilon subdivisions,2WJA2@28221|Deltaproteobacteria,43SU0@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	thiamine pyrophosphate protein TPP binding domain protein	-	-	1.2.5.1,2.2.1.6	ko:K00156,ko:K01652	ko00290,ko00620,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00620,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R03145,R04672,R04673,R08648	RC00027,RC00106,RC00860,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
HKD2_k127_3952699_5	867845.KI911784_gene3486	3.899e-22	110.0	2E5VC@1|root,330JE@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3952699_4	398767.Glov_1113	2.885e-26	119.0	COG0372@1|root,COG0372@2|Bacteria,1R5N1@1224|Proteobacteria	1224|Proteobacteria	C	Belongs to the citrate synthase family	-	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
HKD2_k127_3952699_1	237368.SCABRO_01017	1.152e-136	460.0	COG1629@1|root,COG4771@2|Bacteria,2J2B7@203682|Planctomycetes	203682|Planctomycetes	P	TonB-dependent Receptor Plug Domain	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
HKD2_k127_3952699_3	671143.DAMO_2592	1.818e-26	120.0	COG2984@1|root,COG2984@2|Bacteria,2NPCT@2323|unclassified Bacteria	2|Bacteria	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
HKD2_k127_3952699_6	1499967.BAYZ01000122_gene3398	3.137e-14	83.0	COG3221@1|root,COG3221@2|Bacteria	2|Bacteria	P	organic phosphonate transport	-	-	-	ko:K02044	ko02010,map02010	M00223	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.9	-	-	Phosphonate-bd,STAS_2
HKD2_k127_3952699_2	1294142.CINTURNW_3524	1.431e-27	127.0	COG2020@1|root,COG2020@2|Bacteria,1UXZ3@1239|Firmicutes,24T5J@186801|Clostridia,36N3W@31979|Clostridiaceae	186801|Clostridia	O	Isoprenylcysteine carboxyl methyltransferase (ICMT) family	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
HKD2_k127_3977392_5	177437.HRM2_32660	2.189e-47	174.0	COG0071@1|root,COG0071@2|Bacteria,1NA27@1224|Proteobacteria,42VE3@68525|delta/epsilon subdivisions,2WR9Q@28221|Deltaproteobacteria,2MKAV@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	-	-	-	-	-	-	-	-	-	HSP20
HKD2_k127_3977392_6	1167006.UWK_01212	2.513e-46	171.0	COG0071@1|root,COG0071@2|Bacteria,1N4NW@1224|Proteobacteria,42UNZ@68525|delta/epsilon subdivisions,2WR41@28221|Deltaproteobacteria,2MKGX@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Hsp20/alpha crystallin family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
HKD2_k127_3977392_7	1121403.AUCV01000021_gene3596	7.257e-45	170.0	28PNF@1|root,2ZCB7@2|Bacteria,1RA6N@1224|Proteobacteria,42RBI@68525|delta/epsilon subdivisions,2WN4P@28221|Deltaproteobacteria,2MJHU@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3977392_2	1121405.dsmv_3250	6.463e-115	379.0	COG0730@1|root,COG0730@2|Bacteria,1R3V4@1224|Proteobacteria,42NFH@68525|delta/epsilon subdivisions,2WITT@28221|Deltaproteobacteria,2MHQE@213118|Desulfobacterales	28221|Deltaproteobacteria	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
HKD2_k127_3977392_1	1121403.AUCV01000034_gene3877	5.805e-204	646.0	COG0177@1|root,COG0708@1|root,COG0177@2|Bacteria,COG0708@2|Bacteria,1MUYQ@1224|Proteobacteria,42R18@68525|delta/epsilon subdivisions,2WN0H@28221|Deltaproteobacteria,2MIQV@213118|Desulfobacterales	28221|Deltaproteobacteria	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	-	3.1.11.2,4.2.99.18	ko:K01142,ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,Exo_endo_phos,HhH-GPD
HKD2_k127_3977392_3	1121403.AUCV01000034_gene3882	4.307e-104	346.0	COG2269@1|root,COG2269@2|Bacteria,1MU97@1224|Proteobacteria,42MAN@68525|delta/epsilon subdivisions,2WJBB@28221|Deltaproteobacteria,2MI3I@213118|Desulfobacterales	28221|Deltaproteobacteria	J	class II (D K and N)	genX	-	-	ko:K04568	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	tRNA-synt_2
HKD2_k127_3977392_4	1121403.AUCV01000034_gene3883	1.051e-101	332.0	COG0231@1|root,COG0231@2|Bacteria,1MW2J@1224|Proteobacteria,42N6H@68525|delta/epsilon subdivisions,2WNG7@28221|Deltaproteobacteria,2MHWW@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase	efp	GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K02356	-	-	-	-	ko00000,ko03012	-	-	-	EFP,EFP_N,Elong-fact-P_C
HKD2_k127_3977392_0	1167006.UWK_02855	2.963e-218	707.0	COG0784@1|root,COG4191@1|root,COG0784@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42N46@68525|delta/epsilon subdivisions,2WJT4@28221|Deltaproteobacteria,2MPMZ@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,PocR,Response_reg
HKD2_k127_3977392_9	580332.Slit_2517	1.196e-27	131.0	COG4191@1|root,COG5001@1|root,COG4191@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GAF_2,GGDEF,PAS_3,PAS_9,Response_reg
HKD2_k127_3977392_8	1121403.AUCV01000034_gene3884	1.574e-40	156.0	COG0622@1|root,COG0622@2|Bacteria,1N8BH@1224|Proteobacteria	1224|Proteobacteria	S	Phosphoesterase	-	-	-	ko:K07095	-	-	-	-	ko00000	-	-	-	Metallophos_2
HKD2_k127_3981205_3	1167006.UWK_01951	3.27e-86	295.0	COG4191@1|root,COG4191@2|Bacteria,1R7KQ@1224|Proteobacteria,42PAP@68525|delta/epsilon subdivisions,2WITB@28221|Deltaproteobacteria,2MHP3@213118|Desulfobacterales	28221|Deltaproteobacteria	T	PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	2.7.13.3	ko:K02482	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,dCache_1
HKD2_k127_3981205_7	706587.Desti_4446	7.671e-31	126.0	COG0745@1|root,COG0745@2|Bacteria,1MZGI@1224|Proteobacteria,42UM3@68525|delta/epsilon subdivisions,2WR2K@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
HKD2_k127_3981205_0	555779.Dthio_PD1786	7.396e-178	570.0	COG0451@1|root,COG0664@1|root,COG0451@2|Bacteria,COG0664@2|Bacteria,1R0WU@1224|Proteobacteria,42ZB4@68525|delta/epsilon subdivisions,2WTRM@28221|Deltaproteobacteria	28221|Deltaproteobacteria	GM	epimerase dehydratase	-	-	5.1.3.26	ko:K19997	-	-	-	-	ko00000,ko01000	-	-	-	Epimerase
HKD2_k127_3981205_6	243231.GSU1321	1.11e-39	156.0	COG0526@1|root,COG0526@2|Bacteria,1N726@1224|Proteobacteria,42U61@68525|delta/epsilon subdivisions,2WQRF@28221|Deltaproteobacteria,43UYU@69541|Desulfuromonadales	28221|Deltaproteobacteria	CO	Thioredoxin-like	resA	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
HKD2_k127_3981205_4	1167006.UWK_00350	1.722e-73	251.0	COG1971@1|root,COG1971@2|Bacteria,1NWBY@1224|Proteobacteria,42RE2@68525|delta/epsilon subdivisions,2WNEN@28221|Deltaproteobacteria,2MK2I@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Probably functions as a manganese efflux pump	mntP	-	-	-	-	-	-	-	-	-	-	-	Mntp
HKD2_k127_3981205_5	1121448.DGI_0750	7.033e-68	235.0	COG1592@1|root,COG1592@2|Bacteria,1R9WG@1224|Proteobacteria,42RFX@68525|delta/epsilon subdivisions,2WN92@28221|Deltaproteobacteria,2M9VS@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	PFAM Rubrerythrin	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
HKD2_k127_3981205_1	1121405.dsmv_2703	2.95e-129	421.0	COG0842@1|root,COG0842@2|Bacteria,1Q99P@1224|Proteobacteria,42M53@68525|delta/epsilon subdivisions,2WMEY@28221|Deltaproteobacteria,2MIY1@213118|Desulfobacterales	28221|Deltaproteobacteria	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane,ABC2_membrane_3
HKD2_k127_3981205_2	1121405.dsmv_2702	5.875e-111	366.0	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,42MV1@68525|delta/epsilon subdivisions,2WM7T@28221|Deltaproteobacteria,2MI94@213118|Desulfobacterales	28221|Deltaproteobacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990,ko:K09695	ko02010,map02010	M00252,M00254	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.102	-	-	ABC_tran,DUF4162
HKD2_k127_3987609_7	1121403.AUCV01000060_gene3703	3.637e-30	123.0	2EQFP@1|root,33I1P@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3987609_5	1121405.dsmv_3191	1.316e-52	191.0	COG3108@1|root,COG3108@2|Bacteria,1MWW2@1224|Proteobacteria,42U9S@68525|delta/epsilon subdivisions,2WQ1X@28221|Deltaproteobacteria,2MK54@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Bacterial protein of unknown function (DUF882)	ycbK	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M15_2
HKD2_k127_3987609_1	589865.DaAHT2_1232	1.099e-157	505.0	COG1180@1|root,COG1180@2|Bacteria,1NQC1@1224|Proteobacteria,42N7U@68525|delta/epsilon subdivisions,2WJ81@28221|Deltaproteobacteria,2MI27@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM Radical SAM	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
HKD2_k127_3987609_0	1121403.AUCV01000051_gene2137	4.98e-188	597.0	COG1066@1|root,COG1066@2|Bacteria,1MUJQ@1224|Proteobacteria,42MG8@68525|delta/epsilon subdivisions,2WJWP@28221|Deltaproteobacteria,2MHZV@213118|Desulfobacterales	28221|Deltaproteobacteria	O	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function	radA	-	-	ko:K04485	-	-	-	-	ko00000,ko03400	-	-	-	AAA_25,ATPase,ChlI,Lon_C
HKD2_k127_3987609_6	1121405.dsmv_2893	1.479e-48	185.0	2D8KS@1|root,32TRI@2|Bacteria,1N3IA@1224|Proteobacteria,42USM@68525|delta/epsilon subdivisions,2WQKG@28221|Deltaproteobacteria,2MKFW@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3987609_3	1123277.KB893195_gene5530	2.823e-72	254.0	COG0564@1|root,COG0564@2|Bacteria,4NHCT@976|Bacteroidetes,47N1U@768503|Cytophagia	976|Bacteroidetes	J	Responsible for synthesis of pseudouridine from uracil	rluD	-	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
HKD2_k127_3987609_2	1121918.ARWE01000001_gene199	1.481e-98	332.0	COG2826@1|root,COG2826@2|Bacteria,1MWI0@1224|Proteobacteria	1224|Proteobacteria	L	IS30 family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_38,rve
HKD2_k127_3987609_4	1197477.IA57_05815	2.982e-57	203.0	COG5563@1|root,COG5563@2|Bacteria,4NI94@976|Bacteroidetes,1HZ68@117743|Flavobacteriia	976|Bacteroidetes	M	COG3210 Large exoproteins involved in heme utilization or adhesion	-	-	-	-	-	-	-	-	-	-	-	-	FG-GAP_2
HKD2_k127_4005883_6	754476.Q7A_2839	1.414e-167	537.0	COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,1RR00@1236|Gammaproteobacteria,4601B@72273|Thiotrichales	72273|Thiotrichales	EH	Belongs to the TPP enzyme family	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
HKD2_k127_4005883_4	1121403.AUCV01000002_gene495	6.524e-188	617.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,43BKN@68525|delta/epsilon subdivisions,2X8D5@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_9,Response_reg
HKD2_k127_4005883_31	1122139.KB907874_gene2688	2.485e-07	59.0	COG1925@1|root,COG1925@2|Bacteria,1N6RM@1224|Proteobacteria,1SCXX@1236|Gammaproteobacteria,1XKZ0@135619|Oceanospirillales	135619|Oceanospirillales	G	Phosphocarrier protein HPr	ptsO	-	-	ko:K08485,ko:K11189	ko02060,map02060	-	-	-	ko00000,ko00001,ko02000	4.A.2.1	-	-	PTS-HPr
HKD2_k127_4005883_2	1121403.AUCV01000002_gene499	8.403e-206	656.0	COG1080@1|root,COG1080@2|Bacteria,1MUT8@1224|Proteobacteria,42P77@68525|delta/epsilon subdivisions,2WK7E@28221|Deltaproteobacteria,2MIQB@213118|Desulfobacterales	28221|Deltaproteobacteria	G	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)	ptsI	-	2.7.3.9	ko:K08483	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	8.A.7	-	-	PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C
HKD2_k127_4005883_16	589865.DaAHT2_1499	1.119e-91	315.0	COG0611@1|root,COG0611@2|Bacteria,1MU9X@1224|Proteobacteria,42MYJ@68525|delta/epsilon subdivisions,2WNGE@28221|Deltaproteobacteria,2MK6X@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1	thiL	-	2.7.4.16	ko:K00946	ko00730,ko01100,map00730,map01100	M00127	R00617	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
HKD2_k127_4005883_11	1167006.UWK_02556	3.998e-124	402.0	COG0767@1|root,COG0767@2|Bacteria,1MVPN@1224|Proteobacteria,42MR1@68525|delta/epsilon subdivisions,2WKC9@28221|Deltaproteobacteria,2MJIH@213118|Desulfobacterales	28221|Deltaproteobacteria	Q	Permease MlaE	-	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE
HKD2_k127_4005883_15	1121403.AUCV01000002_gene504	1.821e-101	337.0	COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,42NI4@68525|delta/epsilon subdivisions,2WKRT@28221|Deltaproteobacteria,2MIVB@213118|Desulfobacterales	28221|Deltaproteobacteria	Q	PFAM ABC transporter	-	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran,GGDEF
HKD2_k127_4005883_22	1121403.AUCV01000002_gene505	1.585e-56	200.0	COG1463@1|root,COG1463@2|Bacteria,1NCUG@1224|Proteobacteria,42SCT@68525|delta/epsilon subdivisions,2WPA7@28221|Deltaproteobacteria,2MK72@213118|Desulfobacterales	28221|Deltaproteobacteria	Q	PFAM Mammalian cell entry related domain protein	-	-	-	ko:K02067	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaD
HKD2_k127_4005883_18	1121403.AUCV01000003_gene1665	4.798e-76	263.0	COG2853@1|root,COG2853@2|Bacteria,1MVX0@1224|Proteobacteria,42RII@68525|delta/epsilon subdivisions,2WNS9@28221|Deltaproteobacteria,2MJZ8@213118|Desulfobacterales	28221|Deltaproteobacteria	M	PFAM VacJ family lipoprotein	-	-	-	ko:K04754	-	-	-	-	ko00000	-	-	-	MlaA
HKD2_k127_4005883_24	1121403.AUCV01000019_gene3267	1.233e-50	189.0	COG2854@1|root,COG2854@2|Bacteria,1NKFA@1224|Proteobacteria,42U8G@68525|delta/epsilon subdivisions,2WQPS@28221|Deltaproteobacteria,2MKRJ@213118|Desulfobacterales	28221|Deltaproteobacteria	Q	PFAM toluene tolerance family protein	-	-	-	ko:K07323	ko02010,map02010	M00210	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27.3	-	-	MlaC
HKD2_k127_4005883_26	589865.DaAHT2_1293	2.124e-33	136.0	COG1399@1|root,COG1399@2|Bacteria,1N7GQ@1224|Proteobacteria,42U2P@68525|delta/epsilon subdivisions,2WRMV@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Uncharacterized ACR, COG1399	-	-	-	ko:K07040	-	-	-	-	ko00000	-	-	-	DUF177
HKD2_k127_4005883_30	1167006.UWK_02563	1.926e-23	100.0	COG0333@1|root,COG0333@2|Bacteria,1NGM1@1224|Proteobacteria,42XHF@68525|delta/epsilon subdivisions,2WSX6@28221|Deltaproteobacteria,2MMB1@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Belongs to the bacterial ribosomal protein bL32 family	rpmF	GO:0003674,GO:0003735,GO:0005198	-	ko:K02911	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_L32p
HKD2_k127_4005883_9	1121403.AUCV01000002_gene508	2.015e-134	436.0	COG0416@1|root,COG0416@2|Bacteria,1MVM3@1224|Proteobacteria,42NRV@68525|delta/epsilon subdivisions,2WIXX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA	plsX	-	2.3.1.15	ko:K03621	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FA_synthesis
HKD2_k127_4005883_8	1121403.AUCV01000002_gene509	3.513e-135	438.0	COG0332@1|root,COG0332@2|Bacteria,1MU9N@1224|Proteobacteria,42MU6@68525|delta/epsilon subdivisions,2WIJN@28221|Deltaproteobacteria,2MJ0P@213118|Desulfobacterales	28221|Deltaproteobacteria	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	fabH-2	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
HKD2_k127_4005883_0	1121403.AUCV01000002_gene510	5.273e-210	656.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,42MK5@68525|delta/epsilon subdivisions,2WJ3Z@28221|Deltaproteobacteria,2MI0N@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM Acyl-CoA dehydrogenase	-	-	1.3.8.1	ko:K00248	ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212	-	R01175,R01178,R02661,R03172,R04751	RC00052,RC00068,RC00076,RC00120,RC00148	ko00000,ko00001,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HKD2_k127_4005883_12	1121403.AUCV01000002_gene511	3.906e-121	393.0	COG2086@1|root,COG2086@2|Bacteria,1MVH6@1224|Proteobacteria,42RCI@68525|delta/epsilon subdivisions,2WM55@28221|Deltaproteobacteria,2MPY6@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM Electron transfer flavoprotein	-	-	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
HKD2_k127_4005883_5	1121403.AUCV01000002_gene512	1.671e-170	544.0	COG2025@1|root,COG2025@2|Bacteria,1MUFI@1224|Proteobacteria,42M3T@68525|delta/epsilon subdivisions,2WIV8@28221|Deltaproteobacteria,2MIMG@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Electron transfer flavoprotein, alpha subunit	-	-	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	-	ETF,ETF_alpha,Fer4
HKD2_k127_4005883_14	1121403.AUCV01000002_gene513	2.421e-112	368.0	COG1028@1|root,COG1028@2|Bacteria,1MU6X@1224|Proteobacteria,42MB9@68525|delta/epsilon subdivisions,2WJ64@28221|Deltaproteobacteria,2MJ4H@213118|Desulfobacterales	28221|Deltaproteobacteria	IQ	Short-chain dehydrogenase reductase SDR	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HKD2_k127_4005883_25	1121403.AUCV01000002_gene514	9.691e-34	130.0	COG0236@1|root,COG0236@2|Bacteria,1MZ4P@1224|Proteobacteria,42V9M@68525|delta/epsilon subdivisions,2WRDW@28221|Deltaproteobacteria,2MKUS@213118|Desulfobacterales	28221|Deltaproteobacteria	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	acpP	GO:0000035,GO:0000036,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016053,GO:0019637,GO:0019752,GO:0019842,GO:0031177,GO:0032787,GO:0033218,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044620,GO:0046394,GO:0046467,GO:0046493,GO:0048037,GO:0051192,GO:0071704,GO:0072330,GO:0072341,GO:0090407,GO:0140104,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
HKD2_k127_4005883_1	1121403.AUCV01000002_gene515	7.618e-206	648.0	COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,42MUZ@68525|delta/epsilon subdivisions,2WJT6@28221|Deltaproteobacteria,2MHUV@213118|Desulfobacterales	28221|Deltaproteobacteria	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	fabF	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
HKD2_k127_4005883_23	1167006.UWK_02572	3.863e-53	190.0	COG0698@1|root,COG0698@2|Bacteria,1RHBF@1224|Proteobacteria,42SAN@68525|delta/epsilon subdivisions,2WP1V@28221|Deltaproteobacteria,2MJX4@213118|Desulfobacterales	28221|Deltaproteobacteria	G	ribose 5-phosphate isomerase B	rpiB	-	5.3.1.6	ko:K01808	ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01056,R09030	RC00376,RC00434	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_1604	LacAB_rpiB
HKD2_k127_4005883_3	1167006.UWK_02573	3.4e-205	644.0	COG0112@1|root,COG0112@2|Bacteria,1MUIS@1224|Proteobacteria,42M0T@68525|delta/epsilon subdivisions,2WJ3C@28221|Deltaproteobacteria,2MHY8@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
HKD2_k127_4005883_19	1167006.UWK_02574	2.155e-75	256.0	COG1327@1|root,COG1327@2|Bacteria,1RE7V@1224|Proteobacteria,42SJP@68525|delta/epsilon subdivisions,2WPK0@28221|Deltaproteobacteria,2MJT3@213118|Desulfobacterales	28221|Deltaproteobacteria	K	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes	nrdR	-	-	ko:K07738	-	-	-	-	ko00000,ko03000	-	-	-	ATP-cone
HKD2_k127_4005883_13	1121403.AUCV01000002_gene518	5.755e-113	376.0	COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,1MUWT@1224|Proteobacteria,42NBS@68525|delta/epsilon subdivisions,2WIP2@28221|Deltaproteobacteria,2MIE9@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate	ribD	-	1.1.1.193,3.5.4.26	ko:K11752	ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024	M00125	R03458,R03459	RC00204,RC00933	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_1624	RibD_C,dCMP_cyt_deam_1
HKD2_k127_4005883_17	1121403.AUCV01000002_gene593	4.549e-85	286.0	COG1678@1|root,COG1678@2|Bacteria,1RCXM@1224|Proteobacteria,42SD7@68525|delta/epsilon subdivisions,2WPI5@28221|Deltaproteobacteria,2MIP3@213118|Desulfobacterales	28221|Deltaproteobacteria	K	Belongs to the UPF0301 (AlgH) family	-	-	-	ko:K07735	-	-	-	-	ko00000,ko03000	-	-	-	DUF179
HKD2_k127_4005883_21	1167006.UWK_03178	2.268e-57	202.0	COG0727@1|root,COG0727@2|Bacteria,1N3F5@1224|Proteobacteria,42T7I@68525|delta/epsilon subdivisions,2WQMI@28221|Deltaproteobacteria,2MQ1X@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Putative zinc- or iron-chelating domain	-	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
HKD2_k127_4005883_27	1121403.AUCV01000002_gene591	9.333e-33	132.0	COG1576@1|root,COG1576@2|Bacteria,1N7WB@1224|Proteobacteria,42V41@68525|delta/epsilon subdivisions,2X6IT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA	rlmH	-	2.1.1.177	ko:K00783	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SPOUT_MTase
HKD2_k127_4005883_7	1121403.AUCV01000010_gene1411	1.523e-162	519.0	COG1533@1|root,COG1533@2|Bacteria,1NWJ9@1224|Proteobacteria,42P30@68525|delta/epsilon subdivisions,2WIPV@28221|Deltaproteobacteria,2MHKC@213118|Desulfobacterales	28221|Deltaproteobacteria	L	radical SAM domain protein	-	-	4.1.99.14	ko:K03716	-	-	-	-	ko00000,ko01000	-	-	-	-
HKD2_k127_4005883_20	1121403.AUCV01000010_gene1412	3.597e-59	214.0	COG0629@1|root,COG0629@2|Bacteria,1RCWT@1224|Proteobacteria,42TV9@68525|delta/epsilon subdivisions,2WNAN@28221|Deltaproteobacteria,2MKNW@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Single-stranded DNA-binding protein	ssb	-	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
HKD2_k127_4005883_10	1121403.AUCV01000050_gene2092	4.6e-128	416.0	COG0484@1|root,COG0484@2|Bacteria,1MUZ4@1224|Proteobacteria,42NBY@68525|delta/epsilon subdivisions,2WJV2@28221|Deltaproteobacteria,2MIIH@213118|Desulfobacterales	28221|Deltaproteobacteria	O	heat shock protein DnaJ domain protein	-	-	-	ko:K03686,ko:K05516	-	-	-	-	ko00000,ko03029,ko03036,ko03110	-	-	-	DnaJ,DnaJ_C
HKD2_k127_4053004_1	335543.Sfum_0822	1.314e-98	334.0	COG1035@1|root,COG1152@1|root,COG1035@2|Bacteria,COG1152@2|Bacteria,1R4GN@1224|Proteobacteria,42P9J@68525|delta/epsilon subdivisions,2WJ9S@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	1.17.1.9	ko:K00125	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Fer4,Fer4_17,FrhB_FdhB_C
HKD2_k127_4053004_2	1265505.ATUG01000002_gene1617	1.807e-55	197.0	COG1908@1|root,COG1908@2|Bacteria,1RCZY@1224|Proteobacteria,42RK0@68525|delta/epsilon subdivisions,2WNZZ@28221|Deltaproteobacteria,2MK05@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Methyl-viologen-reducing hydrogenase, delta subunit	-	-	1.8.98.5,1.8.98.6	ko:K14127	ko00680,map00680	-	R00019,R11943,R11944	RC00011	ko00000,ko00001,ko01000	-	-	-	FlpD
HKD2_k127_4053004_0	1265505.ATUG01000002_gene1616	1.497e-221	696.0	COG0493@1|root,COG1148@1|root,COG0493@2|Bacteria,COG1148@2|Bacteria,1MU2H@1224|Proteobacteria,42M6X@68525|delta/epsilon subdivisions,2X6YD@28221|Deltaproteobacteria,2MIN8@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_20,Pyr_redox_2
HKD2_k127_4078108_25	697282.Mettu_2218	8.274e-28	114.0	COG1531@1|root,COG1531@2|Bacteria,1N7PM@1224|Proteobacteria,1SRSR@1236|Gammaproteobacteria	1236|Gammaproteobacteria	AJ	Protein of unknown function (DUF504)	-	-	-	-	-	-	-	-	-	-	-	-	DUF504
HKD2_k127_4078108_21	472759.Nhal_0673	1.036e-42	161.0	COG0517@1|root,COG0517@2|Bacteria,1QYTE@1224|Proteobacteria,1T3TX@1236|Gammaproteobacteria,1WXSV@135613|Chromatiales	135613|Chromatiales	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
HKD2_k127_4078108_2	56780.SYN_01978	1.42e-311	961.0	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,42MMK@68525|delta/epsilon subdivisions,2WJC1@28221|Deltaproteobacteria,2MSIG@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	ABC transporter	yjjK	-	3.6.3.25	ko:K06020	-	-	-	-	ko00000,ko01000	-	-	-	ABC_tran,ABC_tran_Xtn
HKD2_k127_4078108_11	1167006.UWK_00124	5.043e-113	376.0	COG3852@1|root,COG3852@2|Bacteria	2|Bacteria	T	phosphorelay sensor kinase activity	-	-	2.7.13.3	ko:K02668,ko:K07709	ko02020,map02020	M00499,M00501	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	HATPase_c,HisKA,PAS_9,Response_reg,cNMP_binding
HKD2_k127_4078108_24	768670.Calni_0520	3.354e-32	131.0	COG0517@1|root,COG0517@2|Bacteria	2|Bacteria	S	IMP dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	CBS,HATPase_c,HATPase_c_2
HKD2_k127_4078108_6	768670.Calni_0521	7.878e-194	614.0	COG1055@1|root,COG1055@2|Bacteria	2|Bacteria	P	arsenite transmembrane transporter activity	arsB	-	-	-	-	-	-	-	-	-	-	-	CitMHS
HKD2_k127_4078108_17	1121912.AUHD01000003_gene3099	3.357e-58	211.0	COG0744@1|root,COG0744@2|Bacteria,4NF90@976|Bacteroidetes,1HXMN@117743|Flavobacteriia	976|Bacteroidetes	M	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors	mtgA	-	2.4.1.129	ko:K03814	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly
HKD2_k127_4078108_28	404589.Anae109_0772	7.5e-09	64.0	28I8B@1|root,2Z8B5@2|Bacteria,1R013@1224|Proteobacteria,42ZRI@68525|delta/epsilon subdivisions,2WUWF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Cytochrome c bacterial	-	-	-	-	-	-	-	-	-	-	-	-	Cu-binding_MopE,Cytochrome_cB
HKD2_k127_4078108_12	1121403.AUCV01000033_gene3635	1.061e-112	370.0	COG0491@1|root,COG0491@2|Bacteria,1R4FA@1224|Proteobacteria,42TD1@68525|delta/epsilon subdivisions,2WPPD@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HKD2_k127_4078108_4	1121033.AUCF01000013_gene1599	1.187e-274	859.0	COG4770@1|root,COG4770@2|Bacteria,1P6RE@1224|Proteobacteria,2TRC2@28211|Alphaproteobacteria,2JPYX@204441|Rhodospirillales	204441|Rhodospirillales	I	COG4770 Acetyl propionyl-CoA carboxylase, alpha subunit	-	-	6.4.1.3	ko:K01965	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R01859	RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2
HKD2_k127_4078108_23	1121887.AUDK01000011_gene219	3.207e-36	141.0	COG0399@1|root,COG0399@2|Bacteria,4PKRF@976|Bacteroidetes,1IMU3@117743|Flavobacteriia,2P0M0@237|Flavobacterium	976|Bacteroidetes	M	23S rRNA-intervening sequence protein	-	-	-	-	-	-	-	-	-	-	-	-	23S_rRNA_IVP
HKD2_k127_4078108_3	1123354.AUDR01000013_gene618	2.141e-280	870.0	COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,2VIYF@28216|Betaproteobacteria	28216|Betaproteobacteria	I	PFAM carboxyl transferase	pccB	-	2.1.3.15,6.4.1.3	ko:K01966	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R01859	RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
HKD2_k127_4078108_18	1167006.UWK_01577	2.704e-55	196.0	COG0346@1|root,COG0346@2|Bacteria,1RCYU@1224|Proteobacteria,42URG@68525|delta/epsilon subdivisions,2WNDG@28221|Deltaproteobacteria,2MJUI@213118|Desulfobacterales	28221|Deltaproteobacteria	E	PFAM Glyoxalase bleomycin resistance protein dioxygenase	mceE	-	5.1.99.1	ko:K05606	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00375,M00376,M00741	R02765,R09979	RC00780,RC02739	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyoxalase_4
HKD2_k127_4078108_5	1167006.UWK_01578	2.847e-250	783.0	COG1884@1|root,COG1884@2|Bacteria,1MUXX@1224|Proteobacteria,42P03@68525|delta/epsilon subdivisions,2WIPY@28221|Deltaproteobacteria,2MMQV@213118|Desulfobacterales	28221|Deltaproteobacteria	I	Methylmalonyl-CoA mutase	-	-	5.4.99.2	ko:K01848	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	MM_CoA_mutase
HKD2_k127_4078108_13	1167006.UWK_01579	3.319e-96	329.0	COG1703@1|root,COG1703@2|Bacteria,1MVI0@1224|Proteobacteria,42NBN@68525|delta/epsilon subdivisions,2WK8A@28221|Deltaproteobacteria,2MJVA@213118|Desulfobacterales	28221|Deltaproteobacteria	E	ArgK protein	-	-	-	ko:K07588	-	-	-	-	ko00000,ko01000	-	-	-	ArgK
HKD2_k127_4078108_19	1167006.UWK_01580	1.949e-53	197.0	COG2185@1|root,COG2185@2|Bacteria,1RKGS@1224|Proteobacteria,42SKV@68525|delta/epsilon subdivisions,2WP2X@28221|Deltaproteobacteria,2MKRQ@213118|Desulfobacterales	28221|Deltaproteobacteria	I	B12 binding domain	-	-	5.4.99.2	ko:K01849	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding
HKD2_k127_4078108_10	1191523.MROS_2713	5.694e-115	377.0	COG0074@1|root,COG0074@2|Bacteria	2|Bacteria	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit	sucD	-	6.2.1.5	ko:K01902	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_binding,Ligase_CoA
HKD2_k127_4078108_27	485915.Dret_1824	3.289e-14	79.0	2E8QS@1|root,3331S@2|Bacteria,1NN4J@1224|Proteobacteria,4327H@68525|delta/epsilon subdivisions,2WYB5@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4078108_16	96561.Dole_0765	1.56e-67	236.0	2CARY@1|root,32RRX@2|Bacteria,1NGAU@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4078108_26	1121405.dsmv_2416	1.444e-23	101.0	COG1848@1|root,COG1848@2|Bacteria,1NG6D@1224|Proteobacteria,42UHE@68525|delta/epsilon subdivisions,2WR4Q@28221|Deltaproteobacteria,2MNVQ@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	-	-	-	-	-	-	-	-	-	PIN
HKD2_k127_4078108_15	1283300.ATXB01000002_gene3128	9.381e-73	250.0	COG2917@1|root,COG2917@2|Bacteria,1NWIZ@1224|Proteobacteria,1RQAB@1236|Gammaproteobacteria,1XF33@135618|Methylococcales	135618|Methylococcales	D	probably involved in intracellular septation	-	-	-	ko:K06190	-	-	-	-	ko00000	-	-	-	IspA
HKD2_k127_4078108_7	177437.HRM2_32450	4.598e-140	455.0	COG0045@1|root,COG0045@2|Bacteria,1MVCE@1224|Proteobacteria,42M5K@68525|delta/epsilon subdivisions,2WJTS@28221|Deltaproteobacteria,2MHZ2@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit	sucC	-	6.2.1.5	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2261	ATP-grasp_2,Ligase_CoA
HKD2_k127_4078108_1	1167006.UWK_01585	8.05e-322	1001.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,42MHP@68525|delta/epsilon subdivisions,2WJY2@28221|Deltaproteobacteria,2MHX0@213118|Desulfobacterales	28221|Deltaproteobacteria	I	PFAM AMP-dependent synthetase and ligase	-	-	6.2.1.17	ko:K01908	ko00640,ko01100,map00640,map01100	-	R00926,R01354	RC00004,RC00043,RC00070,RC02816	ko00000,ko00001,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
HKD2_k127_4078108_14	1121403.AUCV01000004_gene1954	1.012e-75	266.0	COG2264@1|root,COG2264@2|Bacteria,1MUPC@1224|Proteobacteria,42NSS@68525|delta/epsilon subdivisions,2WIVV@28221|Deltaproteobacteria,2MHQ2@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Methylates ribosomal protein L11	prmA	-	-	ko:K02687	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PrmA
HKD2_k127_4078108_0	1167006.UWK_01139	2.5e-323	1004.0	COG0633@1|root,COG3894@1|root,COG0633@2|Bacteria,COG3894@2|Bacteria,1MV6C@1224|Proteobacteria,42MF5@68525|delta/epsilon subdivisions,2WKC6@28221|Deltaproteobacteria,2MI52@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM ferredoxin	-	-	-	-	-	-	-	-	-	-	-	-	DUF4445,Fer2
HKD2_k127_4078108_20	1396141.BATP01000002_gene4799	2.673e-50	187.0	2DHJ6@1|root,3000S@2|Bacteria,46VCS@74201|Verrucomicrobia,2IVUB@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Protein of unknown function (DUF3302)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3302
HKD2_k127_4078108_8	1396418.BATQ01000120_gene3059	1.408e-131	430.0	COG1566@1|root,COG1566@2|Bacteria,46TG9@74201|Verrucomicrobia	74201|Verrucomicrobia	V	Biotin-lipoyl like	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2
HKD2_k127_4078108_9	1242864.D187_000213	7.28e-124	413.0	COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,42NKZ@68525|delta/epsilon subdivisions,2WK44@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	TIGRFAM RND efflux system, outer membrane lipoprotein, NodT family	-	-	-	ko:K18139	ko01501,ko02024,map01501,map02024	M00642,M00643,M00647,M00718,M00768,M00822	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	1.B.17,2.A.6.2	-	-	MFS_1,OEP
HKD2_k127_408859_1	690850.Desaf_2971	2.288e-129	427.0	COG2203@1|root,COG3437@1|root,COG2203@2|Bacteria,COG3437@2|Bacteria,1RGKE@1224|Proteobacteria,42QI9@68525|delta/epsilon subdivisions,2WIV3@28221|Deltaproteobacteria,2M9A9@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	metal-dependent phosphohydrolase HD region	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HD,Lactamase_B_2
HKD2_k127_408859_2	398767.Glov_2925	6.514e-92	306.0	COG0655@1|root,COG0655@2|Bacteria,1RAK6@1224|Proteobacteria,42QS5@68525|delta/epsilon subdivisions,2WN2M@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
HKD2_k127_408859_3	177439.DP0391	4.281e-73	257.0	COG1075@1|root,COG1075@2|Bacteria,1N2W0@1224|Proteobacteria,42UZK@68525|delta/epsilon subdivisions,2WQ78@28221|Deltaproteobacteria,2MKM7@213118|Desulfobacterales	28221|Deltaproteobacteria	S	acetyltransferases and hydrolases with the alpha beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_408859_0	111780.Sta7437_3364	0.0	1114.0	COG0058@1|root,COG0058@2|Bacteria,1FZUX@1117|Cyanobacteria,3VIE3@52604|Pleurocapsales	1117|Cyanobacteria	G	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties	-	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	Phosphorylase
HKD2_k127_408859_4	880072.Desac_2907	2.312e-48	177.0	COG0205@1|root,COG0205@2|Bacteria,1MVN3@1224|Proteobacteria,42NMZ@68525|delta/epsilon subdivisions,2WIZ0@28221|Deltaproteobacteria,2MRBW@213462|Syntrophobacterales	28221|Deltaproteobacteria	F	Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Atypical ATP- dependent clade X sub-subfamily	pfkA	-	2.7.1.11	ko:K00850	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230	M00001,M00345	R00756,R03236,R03237,R03238,R03239,R04779	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000,ko01009,ko03019	-	-	-	PFK
HKD2_k127_4097056_1	1121403.AUCV01000032_gene2862	3.736e-77	263.0	COG2974@1|root,COG2974@2|Bacteria,1N4GC@1224|Proteobacteria,42RPT@68525|delta/epsilon subdivisions,2WQUM@28221|Deltaproteobacteria,2MJSD@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Putative exonuclease, RdgC	-	-	-	-	-	-	-	-	-	-	-	-	RdgC
HKD2_k127_4097056_0	1121403.AUCV01000002_gene584	6.193e-82	285.0	COG0715@1|root,COG0715@2|Bacteria,1R43C@1224|Proteobacteria,42NY5@68525|delta/epsilon subdivisions,2WMKN@28221|Deltaproteobacteria,2MNID@213118|Desulfobacterales	28221|Deltaproteobacteria	P	NMT1-like family	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1_2
HKD2_k127_4149107_2	592015.HMPREF1705_02026	1.171e-47	174.0	COG0778@1|root,COG0778@2|Bacteria,3TCD8@508458|Synergistetes	508458|Synergistetes	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
HKD2_k127_4149107_5	1499967.BAYZ01000079_gene888	2.296e-28	118.0	COG0664@1|root,COG0664@2|Bacteria	2|Bacteria	T	cyclic nucleotide binding	-	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	cNMP_binding
HKD2_k127_4149107_1	694427.Palpr_1681	2.176e-131	426.0	COG0119@1|root,COG0119@2|Bacteria,4NHR2@976|Bacteroidetes,2FRGF@200643|Bacteroidia,22YPQ@171551|Porphyromonadaceae	976|Bacteroidetes	E	HMGL-like	-	-	4.1.3.39	ko:K01666	ko00360,ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00360,map00362,map00621,map00622,map01100,map01120,map01220	M00545,M00569	R00750	RC00307,RC00371	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	DmpG_comm,HMGL-like
HKD2_k127_4149107_3	324057.Pjdr2_5139	6.281e-44	167.0	COG0800@1|root,COG0800@2|Bacteria,1TS0F@1239|Firmicutes,4HG4G@91061|Bacilli,26WV5@186822|Paenibacillaceae	91061|Bacilli	G	Aldolase	kdgA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	4.1.2.14,4.1.3.42	ko:K01625	ko00030,ko00630,ko01100,ko01120,ko01200,map00030,map00630,map01100,map01120,map01200	M00008,M00061,M00308,M00631	R00470,R05605	RC00307,RC00308,RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldolase
HKD2_k127_4149107_0	269799.Gmet_2803	1.858e-170	548.0	COG4974@1|root,COG4974@2|Bacteria,1MVAN@1224|Proteobacteria,42N7M@68525|delta/epsilon subdivisions,2WIJ0@28221|Deltaproteobacteria,43TH6@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	Phage integrase, N-terminal SAM-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_4,Phage_integrase
HKD2_k127_415500_0	880072.Desac_1527	0.0	1142.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJVV@28221|Deltaproteobacteria,2MQ80@213462|Syntrophobacterales	28221|Deltaproteobacteria	V	TIGRFAM The (Largely Gram-negative Bacterial) Hydrophobe Amphiphile Efflux-1 (HAE1) Family	acrB	-	-	ko:K03296,ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
HKD2_k127_415500_1	880072.Desac_1233	3.773e-192	606.0	COG0845@1|root,COG0845@2|Bacteria,1MU78@1224|Proteobacteria,42NHV@68525|delta/epsilon subdivisions,2WJBA@28221|Deltaproteobacteria,2MR20@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	acrA	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	Biotin_lipoyl_2,HlyD,HlyD_3,HlyD_D23
HKD2_k127_415500_2	880072.Desac_1529	1.529e-106	348.0	COG1309@1|root,COG1309@2|Bacteria,1RCDH@1224|Proteobacteria,42VJ5@68525|delta/epsilon subdivisions,2WN7N@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	PFAM Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
HKD2_k127_4156960_2	368407.Memar_2020	4.014e-38	156.0	COG0642@1|root,arCOG02346@1|root,arCOG06516@1|root,arCOG02346@2157|Archaea,arCOG06192@2157|Archaea,arCOG06516@2157|Archaea	2157|Archaea	T	Histidine kinase-like ATPases	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,GAF_3,HATPase_c,PAS,PAS_3,PAS_4,PAS_9,Response_reg
HKD2_k127_4156960_1	1121035.AUCH01000013_gene3090	2.352e-141	459.0	COG2885@1|root,COG2885@2|Bacteria,1MYBP@1224|Proteobacteria,2VR0Y@28216|Betaproteobacteria,2KVJ4@206389|Rhodocyclales	206389|Rhodocyclales	M	Belongs to the ompA family	-	-	-	-	-	-	-	-	-	-	-	-	Gly-zipper_Omp,OmpA
HKD2_k127_4156960_3	983917.RGE_06520	1.031e-27	118.0	COG0607@1|root,COG0607@2|Bacteria,1RHQZ@1224|Proteobacteria,2VT6V@28216|Betaproteobacteria	28216|Betaproteobacteria	P	Rhodanese-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
HKD2_k127_4156960_0	269799.Gmet_3493	3.416e-153	493.0	COG3256@1|root,COG3256@2|Bacteria,1MVT1@1224|Proteobacteria,42NBM@68525|delta/epsilon subdivisions,2WKTG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	PFAM Cytochrome c oxidase, subunit I	norZ	-	1.7.2.5	ko:K04561	ko00910,ko01120,map00910,map01120	M00529	R00294	RC02794	ko00000,ko00001,ko00002,ko01000	3.D.4.10	-	-	COX1
HKD2_k127_4168154_1	335543.Sfum_0673	6.847e-157	500.0	COG3408@1|root,COG3408@2|Bacteria,1QUN2@1224|Proteobacteria,42PYS@68525|delta/epsilon subdivisions,2WMEG@28221|Deltaproteobacteria,2MRGX@213462|Syntrophobacterales	28221|Deltaproteobacteria	G	Glycogen debranching enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_63
HKD2_k127_4168154_2	251221.35211733	5.161e-106	355.0	COG0837@1|root,COG0837@2|Bacteria,1G1TJ@1117|Cyanobacteria	1117|Cyanobacteria	G	Belongs to the bacterial glucokinase family	glk	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Glucokinase
HKD2_k127_4168154_0	335543.Sfum_1479	1.212e-258	808.0	COG2414@1|root,COG2414@2|Bacteria,1NT3Z@1224|Proteobacteria,42MU9@68525|delta/epsilon subdivisions,2WKD2@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM Aldehyde ferredoxin oxidoreductase	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
HKD2_k127_4168154_3	1121456.ATVA01000017_gene168	1.519e-26	109.0	COG0437@1|root,COG0437@2|Bacteria,1RI8Y@1224|Proteobacteria,42SFX@68525|delta/epsilon subdivisions,2WPGI@28221|Deltaproteobacteria,2MBSP@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	PFAM 4Fe-4S ferredoxin iron-sulfur binding	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_4,Fer4_7
HKD2_k127_4168730_0	1415780.JPOG01000001_gene2740	0.0	1259.0	COG0243@1|root,COG3383@1|root,COG0243@2|Bacteria,COG3383@2|Bacteria,1MW3N@1224|Proteobacteria,1RN6N@1236|Gammaproteobacteria,1XCEY@135614|Xanthomonadales	135614|Xanthomonadales	C	Molydopterin dinucleotide binding domain	-	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
HKD2_k127_4168730_1	472759.Nhal_1618	2.268e-115	375.0	COG0437@1|root,COG0437@2|Bacteria,1MU5T@1224|Proteobacteria,1RRAN@1236|Gammaproteobacteria,1X04F@135613|Chromatiales	135613|Chromatiales	C	PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	-	ko:K00124	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001	-	-	-	Fer4_7
HKD2_k127_4169399_10	65093.PCC7418_1288	2.232e-55	196.0	COG1487@1|root,COG1487@2|Bacteria,1G66B@1117|Cyanobacteria	1117|Cyanobacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
HKD2_k127_4169399_14	1283299.AUKG01000004_gene1046	3.111e-10	64.0	COG2161@1|root,COG2161@2|Bacteria,2HRW6@201174|Actinobacteria,4CTZM@84995|Rubrobacteria	84995|Rubrobacteria	D	Antitoxin Phd_YefM, type II toxin-antitoxin system	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
HKD2_k127_4169399_17	555779.Dthio_PD0105	0.0003497	47.0	COG2026@1|root,COG2026@2|Bacteria,1N76D@1224|Proteobacteria,42VEA@68525|delta/epsilon subdivisions,2WRZP@28221|Deltaproteobacteria,2MFVD@213115|Desulfovibrionales	28221|Deltaproteobacteria	DJ	TIGRFAM addiction module toxin, RelE StbE family	-	-	-	ko:K06218	-	-	-	-	ko00000,ko02048	-	-	-	ParE_toxin
HKD2_k127_4169399_13	1121403.AUCV01000026_gene2369	1.538e-19	89.0	COG1797@1|root,COG1797@2|Bacteria,1MV7Z@1224|Proteobacteria,42M8T@68525|delta/epsilon subdivisions,2WIXE@28221|Deltaproteobacteria,2MHZW@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source	cbiA	-	6.3.5.11,6.3.5.9	ko:K02224	ko00860,ko01100,ko01120,map00860,map01100,map01120	-	R05224,R05815	RC00010,RC01301	ko00000,ko00001,ko01000	-	-	-	AAA_26,CbiA,GATase_3
HKD2_k127_4169399_15	589865.DaAHT2_1671	1.129e-09	63.0	COG1797@1|root,COG1797@2|Bacteria,1MV7Z@1224|Proteobacteria,42M8T@68525|delta/epsilon subdivisions,2WIXE@28221|Deltaproteobacteria,2MHZW@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source	cbiA	-	6.3.5.11,6.3.5.9	ko:K02224	ko00860,ko01100,ko01120,map00860,map01100,map01120	-	R05224,R05815	RC00010,RC01301	ko00000,ko00001,ko01000	-	-	-	AAA_26,CbiA,GATase_3
HKD2_k127_4169399_12	335543.Sfum_1406	3.08e-24	104.0	COG4118@1|root,COG4118@2|Bacteria,1Q43S@1224|Proteobacteria,42VPT@68525|delta/epsilon subdivisions,2WS3C@28221|Deltaproteobacteria	28221|Deltaproteobacteria	D	Antitoxin Phd_YefM, type II toxin-antitoxin system	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
HKD2_k127_4169399_11	335543.Sfum_1407	8.27e-53	189.0	COG4113@1|root,COG4113@2|Bacteria,1N96B@1224|Proteobacteria,42TZ7@68525|delta/epsilon subdivisions,2WR0Y@28221|Deltaproteobacteria,2MS1K@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
HKD2_k127_4169399_3	1167006.UWK_02639	8.912e-183	582.0	COG1797@1|root,COG1797@2|Bacteria,1MV7Z@1224|Proteobacteria,42M8T@68525|delta/epsilon subdivisions,2WIXE@28221|Deltaproteobacteria,2MHZW@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source	cbiA	-	6.3.5.11,6.3.5.9	ko:K02224	ko00860,ko01100,ko01120,map00860,map01100,map01120	-	R05224,R05815	RC00010,RC01301	ko00000,ko00001,ko01000	-	-	-	AAA_26,CbiA,GATase_3
HKD2_k127_4169399_8	1167006.UWK_02638	1.007e-63	226.0	COG2121@1|root,COG2121@2|Bacteria,1MZID@1224|Proteobacteria,42UW6@68525|delta/epsilon subdivisions,2WQ4A@28221|Deltaproteobacteria,2MJZD@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF374)	-	-	-	ko:K09778	-	-	-	-	ko00000	-	-	-	DUF374
HKD2_k127_4169399_0	1121403.AUCV01000026_gene2367	0.0	1030.0	COG0556@1|root,COG0556@2|Bacteria,1MUFK@1224|Proteobacteria,42MFA@68525|delta/epsilon subdivisions,2WJ20@28221|Deltaproteobacteria,2MI3V@213118|Desulfobacterales	28221|Deltaproteobacteria	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	-	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
HKD2_k127_4169399_9	589865.DaAHT2_1346	1.175e-55	201.0	COG0009@1|root,COG0009@2|Bacteria,1MVPM@1224|Proteobacteria,42UBZ@68525|delta/epsilon subdivisions,2WNB6@28221|Deltaproteobacteria,2MJXY@213118|Desulfobacterales	28221|Deltaproteobacteria	J	TIGRFAM Sua5 YciO YrdC YwlC family protein	-	-	2.7.7.87	ko:K07566	-	-	R10463	RC00745	ko00000,ko01000,ko03009,ko03016	-	-	-	Sua5_yciO_yrdC
HKD2_k127_4169399_1	1121403.AUCV01000002_gene609	5.022e-270	842.0	COG0151@1|root,COG0151@2|Bacteria,1MUAH@1224|Proteobacteria,42MCI@68525|delta/epsilon subdivisions,2WJ7H@28221|Deltaproteobacteria,2MIPF@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)	purD	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRC,GARS_A,GARS_C,GARS_N
HKD2_k127_4169399_6	1167006.UWK_03001	1.612e-85	287.0	COG1309@1|root,COG1309@2|Bacteria,1MV2V@1224|Proteobacteria,42NW6@68525|delta/epsilon subdivisions,2WPIG@28221|Deltaproteobacteria,2MI81@213118|Desulfobacterales	28221|Deltaproteobacteria	K	Tetracycline transcriptional regulator YsiA domain protein	-	-	-	ko:K13770	-	-	-	-	ko00000,ko03000	-	-	-	TetR_C_4,TetR_N
HKD2_k127_4169399_7	1121403.AUCV01000002_gene611	4.02e-72	248.0	COG0782@1|root,COG0782@2|Bacteria,1RCXW@1224|Proteobacteria,42SDX@68525|delta/epsilon subdivisions,2WP41@28221|Deltaproteobacteria,2MK62@213118|Desulfobacterales	28221|Deltaproteobacteria	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides	greA	-	-	ko:K03624	-	-	-	-	ko00000,ko03021	-	-	-	GreA_GreB,GreA_GreB_N
HKD2_k127_4169399_4	1121403.AUCV01000002_gene613	2.373e-157	507.0	COG0399@1|root,COG0399@2|Bacteria,1MUPN@1224|Proteobacteria,42M4C@68525|delta/epsilon subdivisions,2WJ1Q@28221|Deltaproteobacteria,2MI8P@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Belongs to the DegT DnrJ EryC1 family	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
HKD2_k127_4169399_5	1121403.AUCV01000002_gene614	3.691e-156	502.0	COG0568@1|root,COG0568@2|Bacteria,1MVWR@1224|Proteobacteria,42NRM@68525|delta/epsilon subdivisions,2WJ0S@28221|Deltaproteobacteria,2MHVP@213118|Desulfobacterales	28221|Deltaproteobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	rpoH	-	-	ko:K03086,ko:K03089	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
HKD2_k127_4169399_16	1123228.AUIH01000003_gene798	1.286e-05	54.0	COG1404@1|root,COG1404@2|Bacteria,1MVJE@1224|Proteobacteria,1RQ2M@1236|Gammaproteobacteria,1XNK7@135619|Oceanospirillales	135619|Oceanospirillales	O	PA domain	-	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_S8
HKD2_k127_4169399_2	926550.CLDAP_27190	6.204e-218	711.0	COG1404@1|root,COG5640@1|root,COG1404@2|Bacteria,COG5640@2|Bacteria	2|Bacteria	O	serine-type endopeptidase activity	vpr	GO:0005575,GO:0005576	3.4.21.4	ko:K01312,ko:K14647	ko02024,ko04080,ko04972,ko04974,ko05164,map02024,map04080,map04972,map04974,map05164	-	-	-	ko00000,ko00001,ko01000,ko01002,ko03110,ko04147	-	-	-	FlgD_ig,Inhibitor_I9,PA,Peptidase_S8,SLH,Trypsin,VCBS
HKD2_k127_4178340_6	1410665.JNKR01000008_gene1082	2.922e-23	100.0	COG1636@1|root,COG1636@2|Bacteria,1TT7H@1239|Firmicutes,4H4DN@909932|Negativicutes	909932|Negativicutes	C	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)	queH	-	1.17.99.6	ko:K09765	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DUF208
HKD2_k127_4178340_5	1121403.AUCV01000035_gene3826	3.62e-98	327.0	COG0127@1|root,COG0127@2|Bacteria,1MUK5@1224|Proteobacteria,42NGT@68525|delta/epsilon subdivisions,2WK3E@28221|Deltaproteobacteria,2MI23@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions	rdgB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576	3.6.1.66	ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000	-	-	iAF987.Gmet_1875	Ham1p_like
HKD2_k127_4178340_7	1265502.KB906012_gene107	7.105e-05	46.0	COG1487@1|root,COG1487@2|Bacteria,1RIB5@1224|Proteobacteria,2VSZV@28216|Betaproteobacteria,4AEWP@80864|Comamonadaceae	28216|Betaproteobacteria	E	Toxic component of a toxin-antitoxin (TA) module. An RNase	vapC	-	2.3.1.30	ko:K00640,ko:K07062	ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111	M00021	R00586	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000,ko02048	-	-	-	PIN
HKD2_k127_4178340_2	1167006.UWK_03209	5.25e-119	388.0	COG0491@1|root,COG0491@2|Bacteria,1MUT2@1224|Proteobacteria,42MVA@68525|delta/epsilon subdivisions,2WKBW@28221|Deltaproteobacteria,2MJ8X@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HKD2_k127_4178340_4	177439.DP0651	3.285e-111	370.0	COG0240@1|root,COG0240@2|Bacteria,1MUU3@1224|Proteobacteria,42NQB@68525|delta/epsilon subdivisions,2WIWW@28221|Deltaproteobacteria,2MIPA@213118|Desulfobacterales	28221|Deltaproteobacteria	I	PFAM NAD-dependent glycerol-3-phosphate dehydrogenase	gpsA	-	1.1.1.94	ko:K00057	ko00564,ko01110,map00564,map01110	-	R00842,R00844	RC00029	ko00000,ko00001,ko01000	-	-	-	NAD_Gly3P_dh_C,NAD_Gly3P_dh_N
HKD2_k127_4178340_3	1121403.AUCV01000017_gene4439	3.172e-111	368.0	COG0188@1|root,COG0188@2|Bacteria,1MUGG@1224|Proteobacteria,42KZ9@68525|delta/epsilon subdivisions,2WJBC@28221|Deltaproteobacteria,2MIKT@213118|Desulfobacterales	28221|Deltaproteobacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
HKD2_k127_4178340_1	880072.Desac_1519	8.494e-207	655.0	COG0188@1|root,COG0188@2|Bacteria,1MUGG@1224|Proteobacteria,42KZ9@68525|delta/epsilon subdivisions,2WJBC@28221|Deltaproteobacteria,2MR01@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
HKD2_k127_4178340_0	1121403.AUCV01000017_gene4440	0.0	1136.0	COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,42M7M@68525|delta/epsilon subdivisions,2WJ9X@28221|Deltaproteobacteria,2MHSK@213118|Desulfobacterales	28221|Deltaproteobacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
HKD2_k127_4193035_2	1304885.AUEY01000078_gene1056	7.99e-33	130.0	COG0604@1|root,COG0604@2|Bacteria,1MV3W@1224|Proteobacteria,42MXJ@68525|delta/epsilon subdivisions,2WKAC@28221|Deltaproteobacteria,2MJ1T@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Zinc-binding dehydrogenase	acuI	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
HKD2_k127_4193035_0	589865.DaAHT2_1635	1.555e-133	435.0	COG0517@1|root,COG0794@1|root,COG0517@2|Bacteria,COG0794@2|Bacteria,1MUXD@1224|Proteobacteria,42M0M@68525|delta/epsilon subdivisions,2WJ4Y@28221|Deltaproteobacteria,2MIJI@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Belongs to the SIS family. GutQ KpsF subfamily	kpsF	-	5.3.1.13	ko:K06041	ko00540,ko01100,map00540,map01100	M00063	R01530	RC00541	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CBS,SIS
HKD2_k127_4193035_4	589865.DaAHT2_2036	7.203e-13	71.0	COG1532@1|root,COG1532@2|Bacteria	2|Bacteria	S	Predicted RNA-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	RNA_bind_2
HKD2_k127_4193035_1	1121403.AUCV01000005_gene310	7.404e-90	325.0	COG0457@1|root,COG5078@1|root,COG0457@2|Bacteria,COG5078@2|Bacteria,1P62E@1224|Proteobacteria,432N1@68525|delta/epsilon subdivisions,2WY4Y@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	PFAM Ubiquitin-conjugating	-	-	-	-	-	-	-	-	-	-	-	-	UQ_con
HKD2_k127_4204574_3	1167006.UWK_03028	2.703e-38	157.0	COG0642@1|root,COG2205@2|Bacteria	1167006.UWK_03028|-	T	PhoQ Sensor	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4204574_1	1167006.UWK_02209	4.426e-199	631.0	COG3005@1|root,COG3005@2|Bacteria,1R956@1224|Proteobacteria,42Q0X@68525|delta/epsilon subdivisions,2WMHI@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	NapC/NirT cytochrome c family, N-terminal region	-	GO:0003674,GO:0003824,GO:0005575,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0022900,GO:0031224,GO:0044237,GO:0044425,GO:0045333,GO:0055114	-	-	-	-	-	-	-	-	-	-	Cytochrom_NNT
HKD2_k127_4204574_0	1121403.AUCV01000007_gene1223	2.175e-263	819.0	COG0107@1|root,COG0118@1|root,COG0107@2|Bacteria,COG0118@2|Bacteria,1MUS0@1224|Proteobacteria,42M44@68525|delta/epsilon subdivisions,2WJFW@28221|Deltaproteobacteria,2MIFH@213118|Desulfobacterales	28221|Deltaproteobacteria	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit	hisF	-	-	ko:K01663,ko:K02500	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase,His_biosynth
HKD2_k127_4204574_2	1121403.AUCV01000007_gene1224	4.107e-77	270.0	COG1208@1|root,COG1208@2|Bacteria,1R9ZD@1224|Proteobacteria,42SI2@68525|delta/epsilon subdivisions,2WPJB@28221|Deltaproteobacteria,2MPTK@213118|Desulfobacterales	28221|Deltaproteobacteria	JM	Nucleotidyl transferase	-	-	2.7.7.13	ko:K00966	ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110	M00114,M00361,M00362	R00885	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
HKD2_k127_4204574_4	267377.MMP0501	1.335e-14	84.0	COG3291@1|root,arCOG03396@2157|Archaea	2157|Archaea	S	amino acid activation for nonribosomal peptide biosynthetic process	-	-	4.2.1.129,5.4.99.17	ko:K06045	ko00909,ko01110,map00909,map01110	-	R07322,R07323	RC01850,RC01851	ko00000,ko00001,ko01000	-	-	-	A2M_comp,CARDB,Prenyltrans,SQHop_cyclase_C,Thiol-ester_cl
HKD2_k127_4209791_3	1121403.AUCV01000006_gene398	9.332e-157	501.0	COG0150@1|root,COG0150@2|Bacteria,1MURG@1224|Proteobacteria,42KZT@68525|delta/epsilon subdivisions,2WIXY@28221|Deltaproteobacteria,2MHNK@213118|Desulfobacterales	28221|Deltaproteobacteria	F	PFAM AIR synthase related protein	purM	-	6.3.3.1	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04208	RC01100	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_1844	AIRS,AIRS_C
HKD2_k127_4209791_7	1167006.UWK_03134	1.131e-62	220.0	COG0521@1|root,COG0521@2|Bacteria,1R9W2@1224|Proteobacteria,42PGH@68525|delta/epsilon subdivisions,2WN91@28221|Deltaproteobacteria,2MPUW@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Probable molybdopterin binding domain	-	-	-	-	-	-	-	-	-	-	-	-	MoCF_biosynth
HKD2_k127_4209791_0	1121403.AUCV01000006_gene396	0.0	1033.0	COG0480@1|root,COG0480@2|Bacteria,1R0V4@1224|Proteobacteria,42M1F@68525|delta/epsilon subdivisions,2WIYM@28221|Deltaproteobacteria,2MHPT@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Elongation factor Tu domain 2	fusA-1	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
HKD2_k127_4209791_1	1121403.AUCV01000006_gene395	8.224e-215	679.0	COG0728@1|root,COG0728@2|Bacteria,1MUH0@1224|Proteobacteria,42M28@68525|delta/epsilon subdivisions,2WJPF@28221|Deltaproteobacteria,2MIBD@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane	murJ	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
HKD2_k127_4209791_6	1121403.AUCV01000006_gene394	4.331e-68	239.0	COG1385@1|root,COG1385@2|Bacteria,1MZBG@1224|Proteobacteria,42UAY@68525|delta/epsilon subdivisions,2X5BX@28221|Deltaproteobacteria,2MQ2T@213118|Desulfobacterales	28221|Deltaproteobacteria	J	RNA methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltrans_RNA
HKD2_k127_4209791_5	177439.DP1705	2.904e-94	324.0	COG1519@1|root,COG1519@2|Bacteria,1MU9F@1224|Proteobacteria,42PCH@68525|delta/epsilon subdivisions,2WMQM@28221|Deltaproteobacteria,2MJDI@213118|Desulfobacterales	28221|Deltaproteobacteria	M	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase)	-	-	2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15	ko:K02527	ko00540,ko01100,map00540,map01100	M00060,M00080	R04658,R05074,R09763	RC00009,RC00077,RC00247	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT30	-	Glycos_transf_N
HKD2_k127_4209791_4	1121403.AUCV01000006_gene383	1.21e-147	497.0	COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,1MUKF@1224|Proteobacteria,42N3S@68525|delta/epsilon subdivisions,2WJ5P@28221|Deltaproteobacteria,2MI3T@213118|Desulfobacterales	28221|Deltaproteobacteria	S	DNA internalization-related competence protein ComEC Rec2	-	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Competence,DUF4131,Lactamase_B
HKD2_k127_4209791_2	1121403.AUCV01000006_gene381	2.346e-205	642.0	COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,42M7F@68525|delta/epsilon subdivisions,2WIMF@28221|Deltaproteobacteria,2MII7@213118|Desulfobacterales	28221|Deltaproteobacteria	NU	PFAM type II secretion system protein E	-	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
HKD2_k127_4209791_8	589865.DaAHT2_0217	3.546e-16	79.0	COG1611@1|root,COG1611@2|Bacteria,1MU6N@1224|Proteobacteria,42P56@68525|delta/epsilon subdivisions,2WK5J@28221|Deltaproteobacteria,2MHV0@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Belongs to the LOG family	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
HKD2_k127_4210677_2	926569.ANT_26880	2.467e-26	126.0	COG1287@1|root,COG1287@2|Bacteria,2G8T3@200795|Chloroflexi	200795|Chloroflexi	S	oligosaccharyl transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4210677_0	1121403.AUCV01000069_gene2305	2.608e-98	328.0	COG0313@1|root,COG0313@2|Bacteria,1MU0E@1224|Proteobacteria,42P3I@68525|delta/epsilon subdivisions,2WM37@28221|Deltaproteobacteria,2MI98@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA	rsmI	-	2.1.1.198	ko:K07056	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TP_methylase
HKD2_k127_4210677_1	118005.AWNK01000006_gene1377	1.277e-36	140.0	COG2199@1|root,COG3706@2|Bacteria	2|Bacteria	T	GGDEF domain	-	-	2.7.7.65	ko:K21088	ko02026,map02026	-	-	-	ko00000,ko00001,ko01000	-	-	-	GGDEF,dCache_2,dCache_3
HKD2_k127_4215397_1	335543.Sfum_2933	1.056e-23	102.0	COG1141@1|root,COG1141@2|Bacteria,1NFG0@1224|Proteobacteria,437Z2@68525|delta/epsilon subdivisions,2X38Y@28221|Deltaproteobacteria,2MSFM@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	-	ko:K05337	-	-	-	-	ko00000	-	-	-	Fer4_13
HKD2_k127_4234536_2	497965.Cyan7822_1606	2.136e-05	52.0	COG1404@1|root,COG2931@1|root,COG4932@1|root,COG1404@2|Bacteria,COG2931@2|Bacteria,COG4932@2|Bacteria,1G1I0@1117|Cyanobacteria,3KI0C@43988|Cyanothece	1117|Cyanobacteria	Q	Haemolysin-type calcium-binding repeat (2 copies)	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin_3,FG-GAP,HemolysinCabind,SdrD_B
HKD2_k127_4234536_0	161156.JQKW01000006_gene1262	5.295e-83	291.0	28JRB@1|root,2Z9H0@2|Bacteria,2GGWS@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	C	Doubled CXXCH motif (Paired_CXXCH_1)	-	-	-	-	-	-	-	-	-	-	-	-	Paired_CXXCH_1
HKD2_k127_4234536_1	1353531.AZNX01000016_gene4333	3.298e-59	219.0	COG0457@1|root,COG3712@1|root,COG4206@1|root,COG0457@2|Bacteria,COG3712@2|Bacteria,COG4206@2|Bacteria,1RJUD@1224|Proteobacteria,2U2AY@28211|Alphaproteobacteria,4BA1D@82115|Rhizobiaceae	28211|Alphaproteobacteria	PT	FecR protein	-	-	-	-	-	-	-	-	-	-	-	-	FecR,TPR_16,TPR_19,TPR_8,TonB_dep_Rec
HKD2_k127_4246914_4	765869.BDW_01710	1.677e-12	77.0	COG1404@1|root,COG1404@2|Bacteria,1R1SH@1224|Proteobacteria,43DB4@68525|delta/epsilon subdivisions,2MTZ1@213481|Bdellovibrionales,2X8H2@28221|Deltaproteobacteria	213481|Bdellovibrionales	O	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4246914_1	584708.Apau_2270	4.634e-67	241.0	COG4584@1|root,COG4584@2|Bacteria,3TBSA@508458|Synergistetes	508458|Synergistetes	L	PFAM Integrase catalytic	-	-	-	-	-	-	-	-	-	-	-	-	rve
HKD2_k127_4246914_0	886293.Sinac_3759	6.409e-106	352.0	COG0604@1|root,COG0604@2|Bacteria,2IYQ6@203682|Planctomycetes	203682|Planctomycetes	C	PFAM Alcohol dehydrogenase GroES-like domain	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N,ADH_zinc_N_2
HKD2_k127_4246914_2	886293.Sinac_3757	1.068e-50	182.0	COG3485@1|root,COG3485@2|Bacteria	2|Bacteria	Q	protocatechuate 3,4-dioxygenase activity	chqB	GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0006725,GO:0008150,GO:0008152,GO:0008199,GO:0009056,GO:0009712,GO:0009987,GO:0016491,GO:0016701,GO:0016702,GO:0018576,GO:0018958,GO:0019114,GO:0019336,GO:0019439,GO:0019614,GO:0019615,GO:0042952,GO:0043167,GO:0043169,GO:0044237,GO:0044248,GO:0046872,GO:0046914,GO:0051213,GO:0055114,GO:0071704,GO:1901360,GO:1901361,GO:1901575,GO:1901615,GO:1901616	1.13.11.1	ko:K03381	ko00361,ko00362,ko00364,ko00623,ko01100,ko01120,ko01220,map00361,map00362,map00364,map00623,map01100,map01120,map01220	M00568	R00817,R04258,R05299,R08114,R08115,R09134	RC00388,RC00535,RC01366	ko00000,ko00001,ko00002,ko01000	-	-	-	Dioxygenase_C,Dioxygenase_N
HKD2_k127_4291176_1	941449.dsx2_2186	9.781e-68	239.0	COG1007@1|root,COG1007@2|Bacteria,1MV56@1224|Proteobacteria,42QMR@68525|delta/epsilon subdivisions,2WJSY@28221|Deltaproteobacteria,2M9EA@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoN-2	-	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	iAF987.Gmet_0172	Proton_antipo_M
HKD2_k127_4291176_5	1123371.ATXH01000003_gene1913	1.607e-26	115.0	COG0589@1|root,COG0589@2|Bacteria,2GHNB@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD2_k127_4291176_4	420662.Mpe_A3241	6.284e-29	122.0	COG1226@1|root,31669@2|Bacteria,1RIW0@1224|Proteobacteria,2VWNP@28216|Betaproteobacteria	28216|Betaproteobacteria	P	COG1226 Kef-type K transport systems	-	-	-	-	-	-	-	-	-	-	-	-	Ion_trans_2
HKD2_k127_4291176_0	933262.AXAM01000019_gene1095	1.34e-119	410.0	COG2203@1|root,COG2204@1|root,COG3852@1|root,COG2203@2|Bacteria,COG2204@2|Bacteria,COG3852@2|Bacteria	2|Bacteria	T	phosphorelay sensor kinase activity	regM	-	-	-	-	-	-	-	-	-	-	-	GAF,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
HKD2_k127_4291176_3	452637.Oter_0822	1.102e-33	150.0	COG0642@1|root,COG3279@1|root,COG2205@2|Bacteria,COG3279@2|Bacteria,46TGZ@74201|Verrucomicrobia	74201|Verrucomicrobia	T	histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg
HKD2_k127_4291176_2	1286631.X805_37160	1.517e-38	164.0	COG4191@1|root,COG4191@2|Bacteria,1R3RN@1224|Proteobacteria,2VPMH@28216|Betaproteobacteria	28216|Betaproteobacteria	T	ATP-binding region ATPase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c
HKD2_k127_4291176_6	398767.Glov_1114	0.0001812	44.0	COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,42M1X@68525|delta/epsilon subdivisions,2WJA2@28221|Deltaproteobacteria,43SU0@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	thiamine pyrophosphate protein TPP binding domain protein	-	-	1.2.5.1,2.2.1.6	ko:K00156,ko:K01652	ko00290,ko00620,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00620,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R03145,R04672,R04673,R08648	RC00027,RC00106,RC00860,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
HKD2_k127_4339064_2	56780.SYN_01404	4.746e-151	490.0	COG2203@1|root,COG2804@1|root,COG2203@2|Bacteria,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,42P9Y@68525|delta/epsilon subdivisions,2WM6A@28221|Deltaproteobacteria	28221|Deltaproteobacteria	NU	General secretory system II protein E domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,T2SSE,T2SSE_N
HKD2_k127_4339064_3	697282.Mettu_1886	1.445e-44	167.0	COG5455@1|root,COG5455@2|Bacteria,1RJ9A@1224|Proteobacteria,1SAW9@1236|Gammaproteobacteria,1XFG9@135618|Methylococcales	135618|Methylococcales	S	response to cobalt ion	-	-	-	-	-	-	-	-	-	-	-	-	RcnB
HKD2_k127_4339064_0	243231.GSU0169	3.897e-286	887.0	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,42M2A@68525|delta/epsilon subdivisions,2WJ41@28221|Deltaproteobacteria,43T6U@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	PFAM ABC transporter related	ybiT	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,ABC_tran_Xtn
HKD2_k127_4339064_1	1167006.UWK_03137	2.318e-186	601.0	COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,42MGZ@68525|delta/epsilon subdivisions,2WIY6@28221|Deltaproteobacteria,2MI9C@213118|Desulfobacterales	28221|Deltaproteobacteria	L	DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation	deaD	-	3.6.4.13	ko:K05592	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019	-	-	-	DEAD,DbpA,Helicase_C
HKD2_k127_434042_1	1187851.A33M_3524	6.126e-83	278.0	COG4177@1|root,COG4177@2|Bacteria,1MWP3@1224|Proteobacteria,2VEXG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HKD2_k127_434042_0	1187851.A33M_3523	3.382e-137	441.0	COG0559@1|root,COG0559@2|Bacteria,1MY1E@1224|Proteobacteria,2TSIQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HKD2_k127_4340780_1	1121403.AUCV01000025_gene2283	5.878e-168	540.0	COG0821@1|root,COG0821@2|Bacteria,1MUAX@1224|Proteobacteria,42M3V@68525|delta/epsilon subdivisions,2WJJ4@28221|Deltaproteobacteria,2MHT5@213118|Desulfobacterales	28221|Deltaproteobacteria	I	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate	ispG	GO:0003674,GO:0003824,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016491,GO:0016725,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046429,GO:0046490,GO:0052592,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901576	1.17.7.1,1.17.7.3	ko:K03526	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R08689,R10859	RC01486	ko00000,ko00001,ko00002,ko01000	-	-	-	GcpE
HKD2_k127_4340780_15	177439.DP1162	1.099e-44	171.0	COG1214@1|root,COG1214@2|Bacteria,1MXPH@1224|Proteobacteria,42RIT@68525|delta/epsilon subdivisions,2WP64@28221|Deltaproteobacteria,2MJX0@213118|Desulfobacterales	28221|Deltaproteobacteria	O	PFAM peptidase M22 glycoprotease	yeaZ	-	2.3.1.234	ko:K01409,ko:K14742	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
HKD2_k127_4340780_3	1121403.AUCV01000025_gene2281	2.578e-143	463.0	COG0750@1|root,COG0750@2|Bacteria,1MU91@1224|Proteobacteria,42NJ0@68525|delta/epsilon subdivisions,2WJ7A@28221|Deltaproteobacteria,2MIEV@213118|Desulfobacterales	28221|Deltaproteobacteria	M	SMART PDZ DHR GLGF domain protein	rseP	-	-	ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_M50
HKD2_k127_4340780_2	1167006.UWK_02082	1.526e-150	500.0	COG0743@1|root,COG0743@2|Bacteria,1MU4G@1224|Proteobacteria,42NI1@68525|delta/epsilon subdivisions,2WK14@28221|Deltaproteobacteria,2MIFC@213118|Desulfobacterales	28221|Deltaproteobacteria	I	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)	dxr	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016114,GO:0016491,GO:0016614,GO:0016616,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030145,GO:0030604,GO:0032787,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046490,GO:0046872,GO:0046914,GO:0048037,GO:0050661,GO:0050662,GO:0051483,GO:0051484,GO:0055114,GO:0070402,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901265,GO:1901363,GO:1901576	1.1.1.267	ko:K00099	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05688	RC01452	ko00000,ko00001,ko00002,ko01000	-	-	-	DXPR_C,DXP_redisom_C,DXP_reductoisom
HKD2_k127_4340780_14	177439.DP1159	5.675e-50	187.0	COG4589@1|root,COG4589@2|Bacteria,1R34Q@1224|Proteobacteria,42QTH@68525|delta/epsilon subdivisions,2WQ6V@28221|Deltaproteobacteria,2MIDG@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Belongs to the CDS family	cdsA	-	2.7.7.41	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_1
HKD2_k127_4340780_7	1121403.AUCV01000025_gene2278	2.421e-97	334.0	COG0020@1|root,COG0020@2|Bacteria,1MVP1@1224|Proteobacteria,42PTV@68525|delta/epsilon subdivisions,2WMWK@28221|Deltaproteobacteria,2MIZD@213118|Desulfobacterales	28221|Deltaproteobacteria	I	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids	uppS	-	2.5.1.31	ko:K00806	ko00900,ko01110,map00900,map01110	-	R06447	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
HKD2_k127_4340780_10	1121403.AUCV01000025_gene2277	5.505e-80	270.0	COG0233@1|root,COG0233@2|Bacteria,1N66T@1224|Proteobacteria,42NAA@68525|delta/epsilon subdivisions,2WNMN@28221|Deltaproteobacteria,2MJ2A@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another	frr	GO:0002181,GO:0002184,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043021,GO:0043023,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576	-	ko:K02838	-	-	-	-	ko00000,ko03012	-	-	-	RRF
HKD2_k127_4340780_5	1121403.AUCV01000025_gene2276	1.295e-100	333.0	COG0528@1|root,COG0528@2|Bacteria,1MV3N@1224|Proteobacteria,42M3X@68525|delta/epsilon subdivisions,2WJDF@28221|Deltaproteobacteria,2MIR4@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Catalyzes the reversible phosphorylation of UMP to UDP	pyrH	GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901576	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
HKD2_k127_4340780_8	589865.DaAHT2_0968	3.341e-95	314.0	COG0264@1|root,COG0264@2|Bacteria,1MUS2@1224|Proteobacteria,42NNS@68525|delta/epsilon subdivisions,2WMS3@28221|Deltaproteobacteria,2MI7H@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome	tsf	GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K02357	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EF_TS
HKD2_k127_4340780_4	1121403.AUCV01000025_gene2274	8.969e-120	391.0	COG0052@1|root,COG0052@2|Bacteria,1MU33@1224|Proteobacteria,42M3Y@68525|delta/epsilon subdivisions,2WJH5@28221|Deltaproteobacteria,2MJCG@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Belongs to the universal ribosomal protein uS2 family	rpsB	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
HKD2_k127_4340780_9	1167006.UWK_02075	8.633e-82	280.0	COG0727@1|root,COG0727@2|Bacteria,1Q0JM@1224|Proteobacteria,42N6S@68525|delta/epsilon subdivisions,2WMTR@28221|Deltaproteobacteria,2MIXY@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Putative zinc- or iron-chelating domain	-	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
HKD2_k127_4340780_13	1121403.AUCV01000025_gene2272	2.417e-50	181.0	COG0203@1|root,COG0203@2|Bacteria,1RCWN@1224|Proteobacteria,42SBD@68525|delta/epsilon subdivisions,2WP9P@28221|Deltaproteobacteria,2MKCX@213118|Desulfobacterales	28221|Deltaproteobacteria	J	PFAM ribosomal protein L17	rplQ	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02879	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L17
HKD2_k127_4340780_0	1121403.AUCV01000025_gene2271	2.369e-175	554.0	COG0202@1|root,COG0202@2|Bacteria,1MU75@1224|Proteobacteria,42MIX@68525|delta/epsilon subdivisions,2WJ5K@28221|Deltaproteobacteria,2MI89@213118|Desulfobacterales	28221|Deltaproteobacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA	GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576	2.7.7.6	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L
HKD2_k127_4340780_6	1167006.UWK_02072	5.215e-100	331.0	COG0522@1|root,COG0522@2|Bacteria,1MW0U@1224|Proteobacteria,42M5X@68525|delta/epsilon subdivisions,2WJGN@28221|Deltaproteobacteria,2MIGC@213118|Desulfobacterales	28221|Deltaproteobacteria	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit	rpsD	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0019222,GO:0019843,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S4,S4
HKD2_k127_4340780_11	1121403.AUCV01000025_gene2269	2.085e-61	214.0	COG0100@1|root,COG0100@2|Bacteria,1RD0A@1224|Proteobacteria,42R43@68525|delta/epsilon subdivisions,2WPH1@28221|Deltaproteobacteria,2MJYB@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome	rpsK	GO:0000028,GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0048027,GO:0065003,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02948	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S11
HKD2_k127_4340780_12	1167006.UWK_02070	1.806e-55	198.0	COG0099@1|root,COG0099@2|Bacteria,1RD1G@1224|Proteobacteria,42RE3@68525|delta/epsilon subdivisions,2WPD5@28221|Deltaproteobacteria,2MK1T@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits	rpsM	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022613,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02952	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13
HKD2_k127_4340780_17	1167006.UWK_02069	2.084e-12	67.0	COG0257@1|root,COG0257@2|Bacteria	2|Bacteria	J	Belongs to the bacterial ribosomal protein bL36 family	rpmJ	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02919	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L36
HKD2_k127_4340780_16	1121403.AUCV01000025_gene2267	4.392e-21	92.0	COG0361@1|root,COG0361@2|Bacteria,1MZFU@1224|Proteobacteria,42TRU@68525|delta/epsilon subdivisions,2WPZK@28221|Deltaproteobacteria,2MKKE@213118|Desulfobacterales	28221|Deltaproteobacteria	J	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex	infA	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0043021,GO:0043022,GO:0044424,GO:0044444,GO:0044464,GO:0044877	-	ko:K02518	-	-	-	-	ko00000,ko03012	-	-	-	eIF-1a
HKD2_k127_4345574_3	1121403.AUCV01000017_gene4473	7.682e-56	199.0	COG1475@1|root,COG1475@2|Bacteria,1MW2E@1224|Proteobacteria,42M8S@68525|delta/epsilon subdivisions,2WNG8@28221|Deltaproteobacteria,2MIMS@213118|Desulfobacterales	28221|Deltaproteobacteria	K	Belongs to the ParB family	parB	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
HKD2_k127_4345574_5	667014.Thein_1694	5.605e-24	104.0	COG0011@1|root,COG0011@2|Bacteria	2|Bacteria	H	TIGRFAM Protein of	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	-	-	-	-	-	-	-	-	-	Thiamine_BP
HKD2_k127_4345574_1	589865.DaAHT2_2325	7.39e-123	400.0	COG0348@1|root,COG0348@2|Bacteria,1PQG0@1224|Proteobacteria,42PV1@68525|delta/epsilon subdivisions,2WK8H@28221|Deltaproteobacteria,2MNNX@213118|Desulfobacterales	28221|Deltaproteobacteria	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_5
HKD2_k127_4345574_4	1121403.AUCV01000017_gene4471	1.281e-48	178.0	COG3807@1|root,COG3807@2|Bacteria,1RIYJ@1224|Proteobacteria,42SNK@68525|delta/epsilon subdivisions,2WPNS@28221|Deltaproteobacteria,2MK8E@213118|Desulfobacterales	28221|Deltaproteobacteria	S	SH3 domain	-	-	-	-	-	-	-	-	-	-	-	-	SH3_4
HKD2_k127_4345574_0	1121403.AUCV01000035_gene3824	4.413e-263	819.0	COG3604@1|root,COG3604@2|Bacteria,1QTT3@1224|Proteobacteria,42Y69@68525|delta/epsilon subdivisions,2WJ5F@28221|Deltaproteobacteria,2MI66@213118|Desulfobacterales	28221|Deltaproteobacteria	KT	PFAM sigma-54 factor interaction domain-containing protein	-	-	-	ko:K02584	ko02020,map02020	-	-	-	ko00000,ko00001,ko03000	-	-	-	GAF,GAF_2,HTH_8,Sigma54_activat
HKD2_k127_4345574_2	1167006.UWK_01094	2.637e-71	256.0	COG1636@1|root,COG1636@2|Bacteria,1MUG5@1224|Proteobacteria,42M1E@68525|delta/epsilon subdivisions,2WMR5@28221|Deltaproteobacteria,2MJG7@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)	queH	-	1.17.99.6	ko:K09765	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DUF208
HKD2_k127_4382494_1	1121403.AUCV01000046_gene1104	7.109e-105	344.0	COG0017@1|root,COG0017@2|Bacteria,1MWFV@1224|Proteobacteria,42MJX@68525|delta/epsilon subdivisions,2WJDM@28221|Deltaproteobacteria,2MIBQ@213118|Desulfobacterales	28221|Deltaproteobacteria	J	class II (D K and N)	asnS	-	6.1.1.22	ko:K01893	ko00970,map00970	M00359,M00360	R03648	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
HKD2_k127_4382494_0	1121403.AUCV01000046_gene1105	9.888e-243	760.0	COG2262@1|root,COG2262@2|Bacteria,1MUA0@1224|Proteobacteria,42NA6@68525|delta/epsilon subdivisions,2WIMU@28221|Deltaproteobacteria,2MJ6H@213118|Desulfobacterales	28221|Deltaproteobacteria	S	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis	hflX	-	-	ko:K03665	-	-	-	-	ko00000,ko03009	-	-	-	GTP-bdg_M,GTP-bdg_N,MMR_HSR1
HKD2_k127_4382494_4	1167006.UWK_03513	5.501e-36	143.0	COG2199@1|root,COG2199@2|Bacteria,1QV9W@1224|Proteobacteria,43BP5@68525|delta/epsilon subdivisions,2X70F@28221|Deltaproteobacteria,2MPMP@213118|Desulfobacterales	28221|Deltaproteobacteria	T	PilZ domain	-	-	-	-	-	-	-	-	-	-	-	-	PilZ
HKD2_k127_4382494_2	1121403.AUCV01000046_gene1108	6.863e-86	288.0	COG0461@1|root,COG0461@2|Bacteria,1PI8N@1224|Proteobacteria,42QSR@68525|delta/epsilon subdivisions,2WMT5@28221|Deltaproteobacteria,2MJH0@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)	pyrE	-	2.4.2.10	ko:K00762	ko00240,ko01100,map00240,map01100	M00051	R01870	RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran
HKD2_k127_4382494_3	1121403.AUCV01000046_gene1109	6.812e-80	272.0	COG0449@1|root,COG0449@2|Bacteria,1MW4K@1224|Proteobacteria,42KZ7@68525|delta/epsilon subdivisions,2WJP6@28221|Deltaproteobacteria,2MIWZ@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	iAF987.Gmet_1487	GATase_6,SIS
HKD2_k127_4383857_7	439235.Dalk_2841	6.046e-05	46.0	COG1198@1|root,COG1198@2|Bacteria,1MUUZ@1224|Proteobacteria,42MNH@68525|delta/epsilon subdivisions,2WJ4G@28221|Deltaproteobacteria,2MINK@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	-	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,ResIII
HKD2_k127_4383857_1	1121403.AUCV01000002_gene599	5.653e-145	464.0	COG1210@1|root,COG1210@2|Bacteria,1MV5F@1224|Proteobacteria,42MJU@68525|delta/epsilon subdivisions,2WJS4@28221|Deltaproteobacteria,2MHTX@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Nucleotidyl transferase	galU	-	2.7.7.9	ko:K00963	ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130	M00129,M00361,M00362,M00549	R00289	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
HKD2_k127_4383857_0	1121403.AUCV01000002_gene600	0.0	1264.0	COG1643@1|root,COG1643@2|Bacteria,1MUEQ@1224|Proteobacteria,42MD4@68525|delta/epsilon subdivisions,2WJ7Z@28221|Deltaproteobacteria,2MIAK@213118|Desulfobacterales	28221|Deltaproteobacteria	L	TIGRFAM ATP-dependent helicase HrpA	hrpA	-	3.6.4.13	ko:K03578,ko:K03579	-	-	-	-	ko00000,ko01000	-	-	-	AAA_19,DEAD,DUF3418,HA2,Helicase_C,OB_NTP_bind
HKD2_k127_4383857_3	1167006.UWK_00927	4.45e-99	332.0	COG1090@1|root,COG1090@2|Bacteria,1MUB4@1224|Proteobacteria,42QUU@68525|delta/epsilon subdivisions,2WKRY@28221|Deltaproteobacteria,2MN9X@213118|Desulfobacterales	28221|Deltaproteobacteria	S	NAD dependent epimerase/dehydratase family	-	-	-	ko:K07071	-	-	-	-	ko00000	-	-	-	DUF1731,Epimerase
HKD2_k127_4383857_6	1167006.UWK_01186	3.696e-19	91.0	COG2010@1|root,COG2010@2|Bacteria,1NK3D@1224|Proteobacteria	1224|Proteobacteria	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
HKD2_k127_4383857_4	177437.HRM2_46820	1.354e-87	297.0	COG0607@1|root,COG1633@1|root,COG0607@2|Bacteria,COG1633@2|Bacteria,1MZPW@1224|Proteobacteria,42NX5@68525|delta/epsilon subdivisions,2WMJ4@28221|Deltaproteobacteria,2MJ8M@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Rubrerythrin	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese,Rubrerythrin
HKD2_k127_4383857_2	177437.HRM2_46810	1.019e-132	437.0	COG1252@1|root,COG1252@2|Bacteria,1QUKT@1224|Proteobacteria,42MAW@68525|delta/epsilon subdivisions,2WJCB@28221|Deltaproteobacteria,2MHYK@213118|Desulfobacterales	28221|Deltaproteobacteria	C	TIGRFAM Pyridine nucleotide-disulfide oxidoreductase family protein	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2
HKD2_k127_4383857_5	1266925.JHVX01000012_gene1688	3.896e-24	104.0	COG3360@1|root,COG3360@2|Bacteria,1PW6C@1224|Proteobacteria,2VXDE@28216|Betaproteobacteria,373H6@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Dodecin	-	-	-	ko:K09165	-	-	-	-	ko00000	-	-	-	Dodecin
HKD2_k127_4389535_1	1167006.UWK_03022	2.992e-93	318.0	COG2204@1|root,COG3829@1|root,COG2204@2|Bacteria,COG3829@2|Bacteria,1MU0N@1224|Proteobacteria,43BK2@68525|delta/epsilon subdivisions,2X6XX@28221|Deltaproteobacteria,2MPNK@213118|Desulfobacterales	28221|Deltaproteobacteria	T	PFAM Response regulator receiver domain	-	-	-	ko:K02481,ko:K07712,ko:K07713	ko02020,map02020	M00497,M00499	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,PAS_4,PAS_9,Response_reg,Sigma54_activat
HKD2_k127_4389535_2	452637.Oter_1554	5.996e-65	240.0	COG1538@1|root,COG1538@2|Bacteria,46WHQ@74201|Verrucomicrobia	74201|Verrucomicrobia	MU	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
HKD2_k127_4389535_0	452637.Oter_4431	2.372e-111	381.0	COG0845@1|root,COG0845@2|Bacteria,46SVD@74201|Verrucomicrobia,3K8NI@414999|Opitutae	414999|Opitutae	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K07798	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4,8.A.1	-	-	DUF3347,HlyD_D23
HKD2_k127_4389535_3	452637.Oter_4432	2.13e-61	213.0	COG3696@1|root,COG3696@2|Bacteria,46SJ1@74201|Verrucomicrobia,3K7EV@414999|Opitutae	414999|Opitutae	P	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K07787	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4	-	-	ACR_tran
HKD2_k127_4408203_2	1121403.AUCV01000012_gene4020	1.562e-94	314.0	COG0407@1|root,COG0407@2|Bacteria,1MUG1@1224|Proteobacteria,42MV9@68525|delta/epsilon subdivisions,2WJZK@28221|Deltaproteobacteria,2MP6C@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	hemE	GO:0003674,GO:0003824,GO:0004853,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_0016	URO-D
HKD2_k127_4408203_1	1121403.AUCV01000012_gene4021	1.059e-192	604.0	COG0535@1|root,COG0535@2|Bacteria,1MUQP@1224|Proteobacteria,42M55@68525|delta/epsilon subdivisions,2WIKM@28221|Deltaproteobacteria,2MJ60@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM Radical SAM domain protein	-	-	-	ko:K22227	-	-	-	-	ko00000	-	-	-	Fer4_12,Fer4_14,Radical_SAM,SPASM
HKD2_k127_4408203_4	1121403.AUCV01000012_gene4022	6.745e-59	209.0	COG0589@1|root,COG0589@2|Bacteria,1RA7K@1224|Proteobacteria,42V2P@68525|delta/epsilon subdivisions,2WRFB@28221|Deltaproteobacteria,2MM20@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Universal stress protein family	usp-2	-	-	ko:K06149	-	-	-	-	ko00000	-	-	-	Usp
HKD2_k127_4408203_3	1121403.AUCV01000012_gene4024	3.479e-93	317.0	COG1207@1|root,COG1207@2|Bacteria,1RD3B@1224|Proteobacteria,42ZXX@68525|delta/epsilon subdivisions,2WV9N@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Bacterial transferase hexapeptide (six repeats)	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep
HKD2_k127_4408203_0	1121403.AUCV01000012_gene4025	0.0	1137.0	COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,42M9W@68525|delta/epsilon subdivisions,2WJ29@28221|Deltaproteobacteria,2MIDR@213118|Desulfobacterales	28221|Deltaproteobacteria	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon-3	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
HKD2_k127_4438204_4	247490.KSU1_B0383	2.465e-44	183.0	2E4WW@1|root,32ZQY@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4438204_2	1167006.UWK_03269	5.889e-104	347.0	COG0644@1|root,COG0644@2|Bacteria,1MXQY@1224|Proteobacteria,42WD4@68525|delta/epsilon subdivisions,2WSEK@28221|Deltaproteobacteria,2MJCV@213118|Desulfobacterales	28221|Deltaproteobacteria	C	FAD binding domain	-	-	1.3.1.111,1.3.1.83,1.3.99.38	ko:K10960,ko:K21401	ko00860,ko00900,ko01100,ko01110,map00860,map00900,map01100,map01110	-	R02063,R08754,R08755,R08756,R11226,R11518	RC00212,RC00522,RC01823	ko00000,ko00001,ko01000	-	-	-	FAD_binding_3,Lycopene_cycl
HKD2_k127_4438204_3	269799.Gmet_1782	1.116e-85	290.0	COG0861@1|root,COG0861@2|Bacteria,1MWC9@1224|Proteobacteria,42MZB@68525|delta/epsilon subdivisions,2WKV4@28221|Deltaproteobacteria,43TDE@69541|Desulfuromonadales	28221|Deltaproteobacteria	P	Integral membrane protein TerC family	-	-	-	-	-	-	-	-	-	-	-	-	TerC
HKD2_k127_4438204_0	1121403.AUCV01000024_gene3436	4.333e-222	696.0	COG0104@1|root,COG0104@2|Bacteria,1MU5B@1224|Proteobacteria,42M9E@68525|delta/epsilon subdivisions,2WJ3F@28221|Deltaproteobacteria,2MI7I@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
HKD2_k127_4438204_5	1121403.AUCV01000024_gene3435	1.148e-30	124.0	COG1758@1|root,COG1758@2|Bacteria,1N6TX@1224|Proteobacteria,42V07@68525|delta/epsilon subdivisions,2WRQ6@28221|Deltaproteobacteria,2MKV2@213118|Desulfobacterales	28221|Deltaproteobacteria	K	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits	rpoZ	-	2.7.7.6	ko:K03060	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb6
HKD2_k127_4438204_1	1121403.AUCV01000024_gene3434	1.696e-163	518.0	COG0484@1|root,COG0484@2|Bacteria,1MVMS@1224|Proteobacteria,42KZM@68525|delta/epsilon subdivisions,2WJGP@28221|Deltaproteobacteria,2MIAD@213118|Desulfobacterales	28221|Deltaproteobacteria	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
HKD2_k127_4474164_4	1121403.AUCV01000046_gene1089	2.674e-62	222.0	COG0664@1|root,COG1413@1|root,COG0664@2|Bacteria,COG1413@2|Bacteria,1RJYT@1224|Proteobacteria,42T0W@68525|delta/epsilon subdivisions,2WP8U@28221|Deltaproteobacteria,2MK7T@213118|Desulfobacterales	28221|Deltaproteobacteria	T	cyclic nucleotide-binding	-	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	HEAT_2,PilZ,cNMP_binding
HKD2_k127_4474164_1	1121403.AUCV01000046_gene1088	6.336e-241	770.0	COG0433@1|root,COG0433@2|Bacteria,1R7B1@1224|Proteobacteria,42NW4@68525|delta/epsilon subdivisions	1224|Proteobacteria	L	Domain of unknown function DUF87	-	-	-	-	-	-	-	-	-	-	-	-	DUF853,DUF87
HKD2_k127_4474164_2	1121403.AUCV01000046_gene1087	2.134e-220	699.0	COG0305@1|root,COG0305@2|Bacteria,1Q6JX@1224|Proteobacteria,433AP@68525|delta/epsilon subdivisions,2WXA1@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	DnaB-like helicase C terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	DnaB_C
HKD2_k127_4474164_5	1121403.AUCV01000008_gene1614	1.53e-22	100.0	COG1722@1|root,COG1722@2|Bacteria,1Q1MM@1224|Proteobacteria,42X37@68525|delta/epsilon subdivisions,2WSNI@28221|Deltaproteobacteria,2MKWN@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseB	-	3.1.11.6	ko:K03602	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_S
HKD2_k127_4474164_3	1121403.AUCV01000008_gene1613	3.228e-115	380.0	COG0142@1|root,COG0142@2|Bacteria,1MWNG@1224|Proteobacteria,42NPN@68525|delta/epsilon subdivisions,2WIY4@28221|Deltaproteobacteria,2MI29@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Belongs to the FPP GGPP synthase family	ispA	-	2.5.1.1,2.5.1.10,2.5.1.29	ko:K00795,ko:K13789	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00366	R01658,R02003,R02061	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
HKD2_k127_4474164_0	1167006.UWK_02514	8.906e-268	840.0	COG1154@1|root,COG1154@2|Bacteria,1MUSJ@1224|Proteobacteria,42M35@68525|delta/epsilon subdivisions,2WIX5@28221|Deltaproteobacteria,2MI30@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)	dxs	-	2.2.1.7	ko:K01662	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	M00096	R05636	RC00032	ko00000,ko00001,ko00002,ko01000	-	-	-	DXP_synthase_N,Transket_pyr,Transketolase_C
HKD2_k127_4492516_1	589865.DaAHT2_0098	9.8e-83	283.0	COG2271@1|root,COG2271@2|Bacteria,1QX38@1224|Proteobacteria,42NSX@68525|delta/epsilon subdivisions,2WK8G@28221|Deltaproteobacteria,2MJE8@213118|Desulfobacterales	28221|Deltaproteobacteria	G	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_4,Sugar_tr
HKD2_k127_4492516_0	485915.Dret_0454	8.425e-179	576.0	COG1271@1|root,COG2010@1|root,COG1271@2|Bacteria,COG2010@2|Bacteria,1NTJT@1224|Proteobacteria,42NK8@68525|delta/epsilon subdivisions,2WIM0@28221|Deltaproteobacteria,2M8SV@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	PFAM Cytochrome c, class I	-	-	-	-	-	-	-	-	-	-	-	-	Cyt_bd_oxida_I,Cytochrome_CBB3
HKD2_k127_4493571_1	1121403.AUCV01000010_gene1344	2.248e-95	327.0	COG1073@1|root,COG1073@2|Bacteria,1RBV1@1224|Proteobacteria,42M9M@68525|delta/epsilon subdivisions,2WM64@28221|Deltaproteobacteria,2MJJ0@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Serine aminopeptidase, S33	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Hydrolase_4
HKD2_k127_4493571_4	1049564.TevJSym_ag00020	1.573e-17	90.0	2EIMJ@1|root,33CCU@2|Bacteria,1NMXZ@1224|Proteobacteria,1SHQA@1236|Gammaproteobacteria,1J797@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4493571_0	589865.DaAHT2_1038	2.626e-101	338.0	COG1806@1|root,COG1806@2|Bacteria,1MUHU@1224|Proteobacteria,42RV7@68525|delta/epsilon subdivisions,2WNZT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	F	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation	-	-	2.7.11.33,2.7.4.28	ko:K09773	-	-	-	-	ko00000,ko01000	-	-	-	Kinase-PPPase
HKD2_k127_4493571_2	316067.Geob_1673	3.042e-39	153.0	COG2852@1|root,COG2852@2|Bacteria	2|Bacteria	L	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF559
HKD2_k127_4525966_4	1121403.AUCV01000017_gene4442	1.37e-170	542.0	COG0592@1|root,COG0592@2|Bacteria,1MVD9@1224|Proteobacteria,42NQW@68525|delta/epsilon subdivisions,2WJZM@28221|Deltaproteobacteria,2MHS9@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria	dnaN	-	2.7.7.7	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3
HKD2_k127_4525966_7	589865.DaAHT2_2109	3.677e-77	272.0	COG1680@1|root,COG1680@2|Bacteria,1QUYZ@1224|Proteobacteria,42PUC@68525|delta/epsilon subdivisions,2WK0V@28221|Deltaproteobacteria,2MIWD@213118|Desulfobacterales	28221|Deltaproteobacteria	V	PFAM Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
HKD2_k127_4525966_11	589865.DaAHT2_2406	1.2e-39	150.0	COG2044@1|root,COG2044@2|Bacteria,1ND3U@1224|Proteobacteria,43D63@68525|delta/epsilon subdivisions,2WRC1@28221|Deltaproteobacteria,2MP7X@213118|Desulfobacterales	28221|Deltaproteobacteria	S	PFAM DsrE DsrF-like family	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4525966_12	1121403.AUCV01000017_gene4447	3.148e-39	147.0	COG0425@1|root,COG0425@2|Bacteria,1MZA5@1224|Proteobacteria,42VCF@68525|delta/epsilon subdivisions,2WRI6@28221|Deltaproteobacteria,2MNRQ@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Belongs to the sulfur carrier protein TusA family	-	-	-	ko:K04085	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	TusA
HKD2_k127_4525966_2	1121403.AUCV01000017_gene4448	6.144e-181	575.0	COG2391@1|root,COG2391@2|Bacteria,1PF9B@1224|Proteobacteria,42NQX@68525|delta/epsilon subdivisions,2WKDB@28221|Deltaproteobacteria,2MN9C@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Sulphur transport	-	-	-	ko:K07112	-	-	-	-	ko00000	-	-	-	Sulf_transp
HKD2_k127_4525966_10	589865.DaAHT2_1601	1.442e-45	173.0	COG0212@1|root,COG0212@2|Bacteria,1MZG0@1224|Proteobacteria,42U47@68525|delta/epsilon subdivisions,2WQXE@28221|Deltaproteobacteria,2MPZQ@213118|Desulfobacterales	28221|Deltaproteobacteria	H	PFAM 5-formyltetrahydrofolate cyclo-ligase	-	-	6.3.3.2	ko:K01934	ko00670,ko01100,map00670,map01100	-	R02301	RC00183	ko00000,ko00001,ko01000	-	-	-	5-FTHF_cyc-lig
HKD2_k127_4525966_6	1167006.UWK_01080	6.742e-129	421.0	COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,42NQP@68525|delta/epsilon subdivisions,2WIQD@28221|Deltaproteobacteria,2MJGP@213118|Desulfobacterales	28221|Deltaproteobacteria	BQ	PFAM Histone deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
HKD2_k127_4525966_5	1121403.AUCV01000017_gene4451	1.587e-156	501.0	COG3437@1|root,COG3437@2|Bacteria,1RGGM@1224|Proteobacteria,42RTT@68525|delta/epsilon subdivisions,2WNA8@28221|Deltaproteobacteria,2MPRV@213118|Desulfobacterales	28221|Deltaproteobacteria	T	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	HD,HD_5,Response_reg
HKD2_k127_4525966_16	1167006.UWK_01078	5.12e-25	110.0	COG0721@1|root,COG0721@2|Bacteria,1QE6H@1224|Proteobacteria,42VPR@68525|delta/epsilon subdivisions,2WRP0@28221|Deltaproteobacteria,2MM1S@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatC	-	6.3.5.6,6.3.5.7	ko:K02435	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	iAF987.Gmet_0076	Glu-tRNAGln
HKD2_k127_4525966_0	1121403.AUCV01000017_gene4453	2.67e-230	725.0	COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,42MAH@68525|delta/epsilon subdivisions,2WJT7@28221|Deltaproteobacteria,2MI5B@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
HKD2_k127_4525966_3	1121403.AUCV01000017_gene4454	4.002e-173	554.0	COG0079@1|root,COG0079@2|Bacteria,1MW7I@1224|Proteobacteria,42NCH@68525|delta/epsilon subdivisions,2WJDR@28221|Deltaproteobacteria,2MIX3@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily	hisC	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
HKD2_k127_4525966_8	1167006.UWK_01075	6.841e-67	236.0	COG0283@1|root,COG0283@2|Bacteria,1MUUD@1224|Proteobacteria,42STI@68525|delta/epsilon subdivisions,2WP1K@28221|Deltaproteobacteria,2MJJQ@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Belongs to the cytidylate kinase family. Type 1 subfamily	cmk	-	2.7.4.25	ko:K00945	ko00240,ko01100,map00240,map01100	M00052	R00158,R00512,R01665	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytidylate_kin
HKD2_k127_4525966_14	1167006.UWK_01505	3.861e-35	136.0	2ED51@1|root,3371S@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4525966_1	1121403.AUCV01000017_gene4456	4.658e-215	672.0	COG0426@1|root,COG0426@2|Bacteria,1NDXY@1224|Proteobacteria,42N11@68525|delta/epsilon subdivisions,2WJ8Z@28221|Deltaproteobacteria,2MI4R@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM Metallo-beta-lactamase superfamily	roo	-	1.6.3.4	ko:K22405	-	-	-	-	ko00000,ko01000	-	-	-	Flavodoxin_1,Lactamase_B
HKD2_k127_4525966_13	1121403.AUCV01000017_gene4457	3.801e-35	139.0	COG3370@1|root,COG3370@2|Bacteria,1N3DX@1224|Proteobacteria,42UA2@68525|delta/epsilon subdivisions,2WQ2I@28221|Deltaproteobacteria,2MKGA@213118|Desulfobacterales	28221|Deltaproteobacteria	O	peroxiredoxin activity	-	-	-	-	-	-	-	-	-	-	-	-	DrsE
HKD2_k127_4525966_17	563008.HMPREF0665_00469	9.304e-23	100.0	COG1773@1|root,COG1773@2|Bacteria,4NHF0@976|Bacteroidetes,2FUN6@200643|Bacteroidia	976|Bacteroidetes	C	rubredoxin	rubR	-	-	-	-	-	-	-	-	-	-	-	Rubredoxin
HKD2_k127_4525966_9	1121403.AUCV01000017_gene4459	1.746e-63	220.0	COG2033@1|root,COG2033@2|Bacteria,1RHE0@1224|Proteobacteria,42SB9@68525|delta/epsilon subdivisions,2WP2D@28221|Deltaproteobacteria,2MK9G@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Desulfoferrodoxin ferrous iron-binding	dfx	-	1.15.1.2	ko:K05919	-	-	-	-	ko00000,ko01000	-	-	-	Desulfoferrod_N,Desulfoferrodox
HKD2_k127_4525966_19	1167006.UWK_00323	1.001e-11	64.0	COG1592@1|root,COG1592@2|Bacteria,1R9WG@1224|Proteobacteria,42N9V@68525|delta/epsilon subdivisions,2WJWQ@28221|Deltaproteobacteria,2MHUF@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM Rubrerythrin	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
HKD2_k127_4556107_7	1167006.UWK_00423	7.84e-07	53.0	COG2982@1|root,COG2982@2|Bacteria,1NVUY@1224|Proteobacteria,42P4T@68525|delta/epsilon subdivisions,2WKBS@28221|Deltaproteobacteria,2MIDZ@213118|Desulfobacterales	28221|Deltaproteobacteria	M	AsmA-like C-terminal region	-	-	-	ko:K07289	-	-	-	-	ko00000	-	-	-	AsmA,AsmA_2
HKD2_k127_4556107_8	572477.Alvin_3120	0.0003231	53.0	COG2804@1|root,COG2804@2|Bacteria,1QTCB@1224|Proteobacteria,1RY2Z@1236|Gammaproteobacteria,1X2CN@135613|Chromatiales	135613|Chromatiales	NU	Type II secretion system (T2SS), protein E, N-terminal domain	-	-	-	ko:K02652	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE,T2SSE_N
HKD2_k127_4556107_0	1167006.UWK_01005	9.209e-159	514.0	COG0477@1|root,COG2814@2|Bacteria,1QUAS@1224|Proteobacteria,42PDB@68525|delta/epsilon subdivisions,2WJBQ@28221|Deltaproteobacteria,2MJDR@213118|Desulfobacterales	28221|Deltaproteobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_3
HKD2_k127_4556107_3	177439.DP2991	2.653e-99	334.0	COG2896@1|root,COG2896@2|Bacteria,1MW3W@1224|Proteobacteria,42NBV@68525|delta/epsilon subdivisions,2WK0F@28221|Deltaproteobacteria,2MI38@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	GO:0003674,GO:0003824,GO:0006732,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0018130,GO:0019538,GO:0019637,GO:0019720,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0071704,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Fer4_14,Mob_synth_C,Radical_SAM
HKD2_k127_4556107_5	589865.DaAHT2_2400	1.108e-58	206.0	COG2258@1|root,COG2258@2|Bacteria,1RIAF@1224|Proteobacteria,42RG1@68525|delta/epsilon subdivisions,2WNX7@28221|Deltaproteobacteria,2MK2J@213118|Desulfobacterales	28221|Deltaproteobacteria	S	PFAM MOSC domain	-	-	-	-	-	-	-	-	-	-	-	-	MOSC
HKD2_k127_4556107_2	177437.HRM2_03600	2.015e-121	417.0	COG2204@1|root,COG4191@1|root,COG2204@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MC4@68525|delta/epsilon subdivisions,2WIZU@28221|Deltaproteobacteria,2MI2B@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg
HKD2_k127_4556107_6	395493.BegalDRAFT_0732	6.669e-20	98.0	2E3CB@1|root,32YBM@2|Bacteria,1N6WD@1224|Proteobacteria,1SDBT@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Domain of unknown function (DUF4154)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4154
HKD2_k127_4556107_1	1209072.ALBT01000046_gene2566	5.342e-154	513.0	COG1629@1|root,COG4771@2|Bacteria,1MUC1@1224|Proteobacteria,1RNHR@1236|Gammaproteobacteria,1FI87@10|Cellvibrio	1236|Gammaproteobacteria	P	Outer membrane protein beta-barrel family	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
HKD2_k127_4556107_4	105559.Nwat_1158	1.045e-84	290.0	COG1629@1|root,COG4771@2|Bacteria,1MUC1@1224|Proteobacteria,1RNHR@1236|Gammaproteobacteria,1WWBJ@135613|Chromatiales	135613|Chromatiales	M	TonB-dependent Receptor Plug	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
HKD2_k127_456010_3	443144.GM21_0410	3.718e-63	217.0	COG0113@1|root,COG0113@2|Bacteria,1MWMW@1224|Proteobacteria,42N17@68525|delta/epsilon subdivisions,2WJE8@28221|Deltaproteobacteria,43SYT@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Belongs to the ALAD family	hemB	-	4.2.1.24	ko:K01698	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00036	RC00918,RC01781	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ALAD
HKD2_k127_456010_1	1232410.KI421428_gene1179	1.136e-140	461.0	COG1234@1|root,COG1234@2|Bacteria,1PPRD@1224|Proteobacteria,42YJB@68525|delta/epsilon subdivisions,2WTTA@28221|Deltaproteobacteria,43TIZ@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Beta-lactamase superfamily domain	-	-	3.1.26.11	ko:K00784	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Lactamase_B_2
HKD2_k127_456010_2	644968.DFW101_2405	1.044e-79	278.0	COG0034@1|root,COG0034@2|Bacteria,1R0RJ@1224|Proteobacteria,43CZU@68525|delta/epsilon subdivisions,2X883@28221|Deltaproteobacteria,2MHCY@213115|Desulfovibrionales	28221|Deltaproteobacteria	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_456010_0	338966.Ppro_2160	1.215e-295	909.0	COG0069@1|root,COG1145@1|root,COG0069@2|Bacteria,COG1145@2|Bacteria,1MU7B@1224|Proteobacteria,42MF7@68525|delta/epsilon subdivisions,2WJ17@28221|Deltaproteobacteria,43TDD@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Conserved region in glutamate synthase	-	-	1.4.1.13,1.4.1.14	ko:K00265	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4,Fer4_16,Glu_synthase
HKD2_k127_4597876_14	1121403.AUCV01000017_gene4483	6.11e-29	119.0	COG1058@1|root,COG1546@1|root,COG1058@2|Bacteria,COG1546@2|Bacteria,1RH2Y@1224|Proteobacteria,42MQ4@68525|delta/epsilon subdivisions,2WMDT@28221|Deltaproteobacteria,2MHNR@213118|Desulfobacterales	28221|Deltaproteobacteria	S	TIGRFAM competence damage-inducible protein CinA	cinA	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363	3.5.1.42	ko:K03742,ko:K03743	ko00760,map00760	-	R02322	RC00100	ko00000,ko00001,ko01000	-	-	-	CinA,MoCF_biosynth
HKD2_k127_4597876_2	1121403.AUCV01000017_gene4484	2.993e-155	503.0	COG0621@1|root,COG0621@2|Bacteria,1MUCS@1224|Proteobacteria,42MN1@68525|delta/epsilon subdivisions,2WJ1H@28221|Deltaproteobacteria,2MI7N@213118|Desulfobacterales	28221|Deltaproteobacteria	J	MiaB-like tRNA modifying enzyme	mtaB	-	2.8.4.5	ko:K18707	-	-	R10649	RC00003,RC03221	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,UPF0004
HKD2_k127_4597876_5	589865.DaAHT2_1911	2.026e-102	345.0	COG0482@1|root,COG0482@2|Bacteria,1MUT1@1224|Proteobacteria,42MZR@68525|delta/epsilon subdivisions,2WK6B@28221|Deltaproteobacteria,2MIRT@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34	mnmA	-	2.8.1.13	ko:K00566	ko04122,map04122	-	R08700	RC02313,RC02315	ko00000,ko00001,ko01000,ko03016	-	-	-	tRNA_Me_trans
HKD2_k127_4597876_11	1121403.AUCV01000017_gene4486	5.725e-58	203.0	COG2944@1|root,COG2944@2|Bacteria,1N66H@1224|Proteobacteria,42UQW@68525|delta/epsilon subdivisions,2WQQF@28221|Deltaproteobacteria,2MKNP@213118|Desulfobacterales	28221|Deltaproteobacteria	K	sequence-specific DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
HKD2_k127_4597876_13	316275.VSAL_II1093	1.906e-32	133.0	COG4067@1|root,COG4067@2|Bacteria,1N446@1224|Proteobacteria,1SBKS@1236|Gammaproteobacteria,1XXNP@135623|Vibrionales	135623|Vibrionales	O	Putative ATP-dependant zinc protease	-	-	-	-	-	-	-	-	-	-	-	-	Zn_protease
HKD2_k127_4597876_4	1232410.KI421428_gene1008	2.983e-108	357.0	COG1122@1|root,COG1122@2|Bacteria,1N5X0@1224|Proteobacteria,43ADF@68525|delta/epsilon subdivisions,2WMEV@28221|Deltaproteobacteria,43T54@69541|Desulfuromonadales	28221|Deltaproteobacteria	P	part of an ABC transporter complex. Responsible for energy coupling to the transport system	-	-	-	ko:K02006,ko:K16787	ko02010,map02010	M00245,M00246,M00582	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.18,3.A.1.22,3.A.1.23,3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	ABC_tran
HKD2_k127_4597876_9	335543.Sfum_1102	1.697e-88	301.0	COG0619@1|root,COG0619@2|Bacteria,1R2DN@1224|Proteobacteria,43B6A@68525|delta/epsilon subdivisions,2X6JT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	TIGRFAM cobalt ABC transporter, inner membrane subunit CbiQ	-	-	-	ko:K02008	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	CbiQ
HKD2_k127_4597876_3	522306.CAP2UW1_3076	9.172e-117	386.0	COG0310@1|root,COG0310@2|Bacteria,1R70A@1224|Proteobacteria,2VS85@28216|Betaproteobacteria	28216|Betaproteobacteria	P	Cobalamin (Vitamin B12) biosynthesis CbiM protein	cbiM	-	-	ko:K02007	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	CbiM,PDGLE
HKD2_k127_4597876_8	497964.CfE428DRAFT_2468	1.165e-89	302.0	COG0384@1|root,COG0384@2|Bacteria,46SN8@74201|Verrucomicrobia	74201|Verrucomicrobia	S	PFAM Phenazine biosynthesis PhzC PhzF protein	-	-	-	-	-	-	-	-	-	-	-	-	PhzC-PhzF
HKD2_k127_4597876_7	1121403.AUCV01000028_gene2464	1.238e-96	323.0	COG0668@1|root,COG0668@2|Bacteria,1N596@1224|Proteobacteria,42M0U@68525|delta/epsilon subdivisions,2WJR5@28221|Deltaproteobacteria,2MIAJ@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Mechanosensitive ion channel	-	-	-	ko:K03442	-	-	-	-	ko00000,ko02000	1.A.23.2	-	-	LysM,MS_channel,TM_helix
HKD2_k127_4597876_15	760568.Desku_3494	2.827e-15	76.0	COG1148@1|root,COG1148@2|Bacteria,1VMJ0@1239|Firmicutes,25EIC@186801|Clostridia,262UH@186807|Peptococcaceae	186801|Clostridia	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
HKD2_k127_4597876_0	1121403.AUCV01000062_gene3688	8.273e-295	909.0	COG0519@1|root,COG0519@2|Bacteria,1MU2A@1224|Proteobacteria,42M0I@68525|delta/epsilon subdivisions,2WJ6D@28221|Deltaproteobacteria,2MJ7G@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Catalyzes the synthesis of GMP from XMP	guaA	GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase,GMP_synt_C,NAD_synthase,tRNA_Me_trans
HKD2_k127_4597876_1	1121403.AUCV01000062_gene3689	1.274e-249	777.0	COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,1MUJM@1224|Proteobacteria,42M2M@68525|delta/epsilon subdivisions,2WJ5H@28221|Deltaproteobacteria,2MHSU@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth	guaB	-	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,IMPDH,NMO
HKD2_k127_4597876_6	1121403.AUCV01000062_gene3691	2.178e-97	321.0	COG0009@1|root,COG0009@2|Bacteria,1MVPM@1224|Proteobacteria,42QSV@68525|delta/epsilon subdivisions,2WMZ5@28221|Deltaproteobacteria,2MI25@213118|Desulfobacterales	28221|Deltaproteobacteria	J	TIGRFAM Sua5 YciO YrdC YwlC family protein	yrdC	-	2.7.7.87	ko:K07566	-	-	R10463	RC00745	ko00000,ko01000,ko03009,ko03016	-	-	-	Sua5_yciO_yrdC
HKD2_k127_4597876_12	1121403.AUCV01000015_gene4699	4.46e-38	144.0	COG0776@1|root,COG0776@2|Bacteria	2|Bacteria	L	regulation of translation	ihfB	-	3.6.1.11,3.6.1.40	ko:K01524,ko:K03530,ko:K04764,ko:K05788	ko00230,map00230	-	R03409	RC00002	ko00000,ko00001,ko01000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding,Ppx-GppA
HKD2_k127_4597876_10	1121403.AUCV01000015_gene4700	5.772e-76	257.0	COG0539@1|root,COG0539@2|Bacteria,1MVAV@1224|Proteobacteria,42M29@68525|delta/epsilon subdivisions,2WJ0X@28221|Deltaproteobacteria,2MI6Q@213118|Desulfobacterales	28221|Deltaproteobacteria	J	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence	rpsA	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
HKD2_k127_4602377_3	1232410.KI421420_gene3218	4.76e-74	261.0	COG3064@1|root,COG3064@2|Bacteria,1MXPS@1224|Proteobacteria,42PA3@68525|delta/epsilon subdivisions,2WM6X@28221|Deltaproteobacteria,43SGF@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Protein of unknown function (DUF3300)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3300
HKD2_k127_4602377_2	269799.Gmet_1198	2.2e-98	331.0	COG4786@1|root,COG4786@2|Bacteria,1MZXB@1224|Proteobacteria,42MTK@68525|delta/epsilon subdivisions,2WM8U@28221|Deltaproteobacteria,43T3T@69541|Desulfuromonadales	28221|Deltaproteobacteria	N	Protein of unknown function (DUF2950)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2950
HKD2_k127_4602377_1	1121403.AUCV01000012_gene4028	1.245e-219	693.0	COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,1MU9U@1224|Proteobacteria,42N86@68525|delta/epsilon subdivisions,2WIV4@28221|Deltaproteobacteria,2MI8Q@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source	nadE	-	6.3.5.1	ko:K01950	ko00760,ko01100,map00760,map01100	M00115	R00257	RC00010,RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase,NAD_synthase
HKD2_k127_4602377_0	1121403.AUCV01000012_gene4029	2.794e-296	919.0	COG3303@1|root,COG3303@2|Bacteria,1R732@1224|Proteobacteria,42PZ7@68525|delta/epsilon subdivisions,2WJP5@28221|Deltaproteobacteria,2MMBV@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process	cbcN	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_CIII
HKD2_k127_4602377_4	10090.ENSMUSP00000096877	0.0002592	54.0	28V1U@1|root,2R1T7@2759|Eukaryota,38XX8@33154|Opisthokonta,3BHEQ@33208|Metazoa,3CTC7@33213|Bilateria,481WJ@7711|Chordata,497JB@7742|Vertebrata,3J24N@40674|Mammalia,359XK@314146|Euarchontoglires,4Q12E@9989|Rodentia	33208|Metazoa	T	Thrombomodulin like fifth domain, EGF-like	THBD	GO:0000003,GO:0003674,GO:0005488,GO:0005509,GO:0005575,GO:0005576,GO:0005615,GO:0005622,GO:0005623,GO:0005737,GO:0005773,GO:0005774,GO:0005886,GO:0005887,GO:0006950,GO:0007154,GO:0007165,GO:0007565,GO:0007596,GO:0007599,GO:0008150,GO:0009611,GO:0009986,GO:0009987,GO:0010543,GO:0010544,GO:0016020,GO:0016021,GO:0016327,GO:0022414,GO:0023052,GO:0030193,GO:0030194,GO:0030195,GO:0031090,GO:0031224,GO:0031226,GO:0032101,GO:0032102,GO:0032103,GO:0032501,GO:0038023,GO:0042060,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044421,GO:0044422,GO:0044424,GO:0044425,GO:0044437,GO:0044444,GO:0044446,GO:0044459,GO:0044464,GO:0044703,GO:0044706,GO:0046872,GO:0048518,GO:0048519,GO:0048523,GO:0048583,GO:0048584,GO:0048585,GO:0050789,GO:0050794,GO:0050817,GO:0050818,GO:0050819,GO:0050820,GO:0050865,GO:0050866,GO:0050878,GO:0050896,GO:0051239,GO:0051240,GO:0051241,GO:0051704,GO:0051716,GO:0051917,GO:0051918,GO:0060089,GO:0061041,GO:0061045,GO:0065007,GO:0065008,GO:0071944,GO:0080134,GO:0090303,GO:0098588,GO:0098590,GO:0098805,GO:1900046,GO:1900047,GO:1900048,GO:1903034,GO:1903035,GO:1903036	-	ko:K03907	ko04610,ko04933,ko05418,map04610,map04933,map05418	-	-	-	ko00000,ko00001,ko00535,ko04090,ko04091	-	-	-	EGF_CA,FXa_inhibition,Lectin_C,Tme5_EGF_like,cEGF
HKD2_k127_461076_8	1121403.AUCV01000077_gene4330	5.729e-40	149.0	COG0056@1|root,COG0056@2|Bacteria,1MUG7@1224|Proteobacteria,42MVX@68525|delta/epsilon subdivisions,2WIK7@28221|Deltaproteobacteria,2MIHR@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	atpA	-	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
HKD2_k127_461076_4	1121403.AUCV01000077_gene4329	4.118e-128	415.0	COG0224@1|root,COG0224@2|Bacteria,1MU28@1224|Proteobacteria,42N8B@68525|delta/epsilon subdivisions,2WJ6I@28221|Deltaproteobacteria,2MIR3@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex	atpG	-	-	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt
HKD2_k127_461076_1	1121403.AUCV01000077_gene4328	4.408e-278	858.0	COG0055@1|root,COG0055@2|Bacteria,1MUFU@1224|Proteobacteria,42KZA@68525|delta/epsilon subdivisions,2WJ1V@28221|Deltaproteobacteria,2MI99@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits	atpD	-	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_N
HKD2_k127_461076_6	1121403.AUCV01000077_gene4327	4.712e-64	221.0	COG0355@1|root,COG0355@2|Bacteria,1RHE4@1224|Proteobacteria,42TII@68525|delta/epsilon subdivisions,2WPVK@28221|Deltaproteobacteria,2MK6Z@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpC	GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016469,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0045259,GO:0045261,GO:0046034,GO:0046390,GO:0046483,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02114	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_DE,ATP-synt_DE_N
HKD2_k127_461076_2	1167006.UWK_01709	6.871e-217	687.0	COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,42MGY@68525|delta/epsilon subdivisions,2WJHC@28221|Deltaproteobacteria,2MHYJ@213118|Desulfobacterales	28221|Deltaproteobacteria	E	TIGRFAM glutamate synthase (NADPH), homotetrameric	nfnA	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	DHODB_Fe-S_bind,Fer4_20,Pyr_redox_2
HKD2_k127_461076_3	1121403.AUCV01000034_gene3887	4.671e-173	563.0	COG0860@1|root,COG0860@2|Bacteria,1MUQK@1224|Proteobacteria,42MPH@68525|delta/epsilon subdivisions,2WJHW@28221|Deltaproteobacteria,2MHPG@213118|Desulfobacterales	28221|Deltaproteobacteria	M	N-acetylmuramoyl-L-alanine amidase	amiC	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	AMIN,Amidase_3,TPR_6
HKD2_k127_461076_5	382464.ABSI01000006_gene803	3.577e-107	354.0	COG0667@1|root,COG0667@2|Bacteria	2|Bacteria	C	Aldo Keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red,HEAT_2,TetR_C_7,TetR_N
HKD2_k127_461076_0	1121403.AUCV01000034_gene3886	0.0	1106.0	COG0249@1|root,COG0249@2|Bacteria,1MUGX@1224|Proteobacteria,42MRR@68525|delta/epsilon subdivisions,2WIQ7@28221|Deltaproteobacteria,2MIGW@213118|Desulfobacterales	28221|Deltaproteobacteria	L	that it carries out the mismatch recognition step. This protein has a weak ATPase activity	mutS	GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
HKD2_k127_461076_7	1167006.UWK_01712	6.307e-52	186.0	COG0537@1|root,COG0537@2|Bacteria,1RHYQ@1224|Proteobacteria,42SEG@68525|delta/epsilon subdivisions,2WPFW@28221|Deltaproteobacteria,2MNPP@213118|Desulfobacterales	28221|Deltaproteobacteria	FG	HIT domain	-	-	2.7.7.53	ko:K19710	ko00230,map00230	-	R00126,R01618	RC00002,RC02753,RC02795	ko00000,ko00001,ko01000	-	-	-	CwfJ_C_1,HIT
HKD2_k127_4620765_7	626522.GCWU000325_00425	1.754e-46	183.0	COG4642@1|root,COG4642@2|Bacteria,4NJPY@976|Bacteroidetes,2FMDX@200643|Bacteroidia,1WD3C@1283313|Alloprevotella	976|Bacteroidetes	S	Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases.	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	MORN
HKD2_k127_4620765_10	1123371.ATXH01000020_gene469	1.161e-24	114.0	COG1689@1|root,COG1689@2|Bacteria,2GI4V@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	S	Prenyltransferase and squalene oxidase repeat	-	-	-	-	-	-	-	-	-	-	-	-	Prenyltrans
HKD2_k127_4620765_2	1121403.AUCV01000001_gene700	7.735e-169	538.0	COG0205@1|root,COG0205@2|Bacteria,1MVN3@1224|Proteobacteria,42Q5V@68525|delta/epsilon subdivisions,2WJA1@28221|Deltaproteobacteria,2MJ9S@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis	pfk-1	-	2.7.1.11,2.7.1.90	ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
HKD2_k127_4620765_5	880072.Desac_2808	4.986e-88	302.0	COG1226@1|root,COG1226@2|Bacteria,1MU1R@1224|Proteobacteria,42MW6@68525|delta/epsilon subdivisions,2WIYU@28221|Deltaproteobacteria,2MRAG@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	Ion channel	-	-	-	ko:K10716	-	-	-	-	ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	Ion_trans_2,TrkA_C,TrkA_N
HKD2_k127_4620765_4	1121403.AUCV01000009_gene1436	1.302e-136	458.0	COG0319@1|root,COG0854@1|root,COG0319@2|Bacteria,COG0854@2|Bacteria,1MU9W@1224|Proteobacteria,42NZY@68525|delta/epsilon subdivisions,2WJDY@28221|Deltaproteobacteria,2MJ54@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate	pdxJ	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008614,GO:0008615,GO:0009058,GO:0009110,GO:0009987,GO:0016740,GO:0016769,GO:0017144,GO:0018130,GO:0019438,GO:0033856,GO:0034641,GO:0042364,GO:0042816,GO:0042819,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	2.6.99.2	ko:K03474	ko00750,ko01100,map00750,map01100	M00124	R05838	RC01476	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_1885	PdxJ
HKD2_k127_4620765_3	1121403.AUCV01000009_gene1437	1.454e-160	511.0	COG1702@1|root,COG1702@2|Bacteria,1MVDV@1224|Proteobacteria,42N58@68525|delta/epsilon subdivisions,2WIQS@28221|Deltaproteobacteria,2MID1@213118|Desulfobacterales	28221|Deltaproteobacteria	T	PFAM PhoH family protein	phoH2	-	-	ko:K06217	-	-	-	-	ko00000	-	-	-	PhoH
HKD2_k127_4620765_6	1121403.AUCV01000009_gene1438	5.214e-82	283.0	COG1651@1|root,COG1651@2|Bacteria,1MX2T@1224|Proteobacteria,42S4E@68525|delta/epsilon subdivisions,2WNJ8@28221|Deltaproteobacteria,2MQ1C@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Thioredoxin	-	-	-	-	-	-	-	-	-	-	-	-	SurA_N_3,Thioredoxin_4
HKD2_k127_4620765_9	589865.DaAHT2_0740	5.832e-25	116.0	COG1475@1|root,COG1475@2|Bacteria,1RISA@1224|Proteobacteria,42T1I@68525|delta/epsilon subdivisions,2WPDM@28221|Deltaproteobacteria,2MK3R@213118|Desulfobacterales	28221|Deltaproteobacteria	K	ParB domain protein nuclease	-	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
HKD2_k127_4620765_8	1167006.UWK_02577	4.629e-45	165.0	COG0776@1|root,COG0776@2|Bacteria,1RH5Z@1224|Proteobacteria,42W2F@68525|delta/epsilon subdivisions,2WRUM@28221|Deltaproteobacteria,2MKSW@213118|Desulfobacterales	28221|Deltaproteobacteria	K	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control	ihfA	-	-	ko:K04764	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
HKD2_k127_4620765_0	1121403.AUCV01000039_gene4353	1.597e-227	725.0	COG0148@1|root,COG0148@2|Bacteria,1MU1N@1224|Proteobacteria,42MS9@68525|delta/epsilon subdivisions,2WJMS@28221|Deltaproteobacteria,2MI3S@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
HKD2_k127_4620765_1	1121403.AUCV01000039_gene4354	2.307e-192	606.0	COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,42NES@68525|delta/epsilon subdivisions,2WJ0V@28221|Deltaproteobacteria,2MHWD@213118|Desulfobacterales	28221|Deltaproteobacteria	NU	type II secretion system	pilC	-	-	ko:K02653	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSF
HKD2_k127_4638863_0	383372.Rcas_2307	3.909e-86	291.0	COG4305@1|root,COG4305@2|Bacteria,2GADE@200795|Chloroflexi,375JZ@32061|Chloroflexia	32061|Chloroflexia	G	Rare lipoprotein A	-	-	-	ko:K20628	-	-	-	-	ko00000	-	-	-	DPBB_1
HKD2_k127_4638863_3	1470593.BW43_05219	2.203e-06	59.0	COG2303@1|root,COG2303@2|Bacteria,1MU3F@1224|Proteobacteria,1RPBQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	COG2303 Choline dehydrogenase and related flavoproteins	-	-	1.1.5.9	ko:K19813	ko00030,ko01100,ko01110,ko01130,map00030,map01100,map01110,map01130	-	R00305	RC00066	ko00000,ko00001,ko01000	-	-	-	FAD_binding_2,GMC_oxred_C,GMC_oxred_N,NAD_binding_8
HKD2_k127_4638863_1	179408.Osc7112_5196	1.182e-49	185.0	COG0515@1|root,COG0515@2|Bacteria,1G8NX@1117|Cyanobacteria,1HCBP@1150|Oscillatoriales	1117|Cyanobacteria	KLT	serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4675449_0	1121403.AUCV01000012_gene4062	1.166e-316	1000.0	COG0744@1|root,COG5009@1|root,COG0744@2|Bacteria,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,42MJB@68525|delta/epsilon subdivisions,2WIXF@28221|Deltaproteobacteria,2MI9W@213118|Desulfobacterales	28221|Deltaproteobacteria	M	TIGRFAM penicillin-binding protein, 1A family	mrcA	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	iAF987.Gmet_0354	PCB_OB,Transgly,Transpeptidase
HKD2_k127_4675449_1	443143.GM18_2824	1.65e-157	524.0	COG0834@1|root,COG4191@1|root,COG4936@1|root,COG0834@2|Bacteria,COG4191@2|Bacteria,COG4936@2|Bacteria,1RCM9@1224|Proteobacteria,42PH8@68525|delta/epsilon subdivisions,2WKUF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,PocR,Response_reg
HKD2_k127_468932_2	665571.STHERM_c14880	3.884e-35	139.0	COG0170@1|root,COG0344@1|root,COG0170@2|Bacteria,COG0344@2|Bacteria	2|Bacteria	I	acyl-phosphate glycerol-3-phosphate acyltransferase activity	plsY	-	2.3.1.15	ko:K08591	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	G3P_acyltransf
HKD2_k127_468932_0	309799.DICTH_1773	4.279e-100	332.0	COG1215@1|root,COG1215@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HKD2_k127_468932_1	1329516.JPST01000007_gene1542	1.584e-46	179.0	COG1307@1|root,COG1307@2|Bacteria,1TRM7@1239|Firmicutes,4HBIR@91061|Bacilli,27BEX@186824|Thermoactinomycetaceae	91061|Bacilli	S	Dihydroxyacetone kinase family	degV3	-	-	-	-	-	-	-	-	-	-	-	DegV
HKD2_k127_470184_3	1163617.SCD_n00707	1.159e-32	128.0	COG1361@1|root,COG1361@2|Bacteria,1R5HW@1224|Proteobacteria,2VZ99@28216|Betaproteobacteria	28216|Betaproteobacteria	M	Protein of unknown function (DUF1566)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1566
HKD2_k127_470184_1	1167006.UWK_00061	1.153e-236	769.0	COG0265@1|root,COG0308@1|root,COG3016@1|root,COG0265@2|Bacteria,COG0308@2|Bacteria,COG3016@2|Bacteria,1MX1I@1224|Proteobacteria,42U2R@68525|delta/epsilon subdivisions,2WQAR@28221|Deltaproteobacteria,2MPWA@213118|Desulfobacterales	28221|Deltaproteobacteria	EO	Haem-binding uptake, Tiki superfamily, ChaN	-	-	-	-	-	-	-	-	-	-	-	-	Cofac_haem_bdg,PDZ_2,Peptidase_M1
HKD2_k127_470184_2	1167006.UWK_00059	5.302e-147	476.0	COG0111@1|root,COG0111@2|Bacteria,1MU5Z@1224|Proteobacteria,42YAK@68525|delta/epsilon subdivisions,2WTYC@28221|Deltaproteobacteria,2MPRI@213118|Desulfobacterales	28221|Deltaproteobacteria	EH	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain	-	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
HKD2_k127_470184_0	589865.DaAHT2_1713	2.239e-312	965.0	COG1048@1|root,COG1048@2|Bacteria,1MU9T@1224|Proteobacteria,42N5M@68525|delta/epsilon subdivisions,2WIIV@28221|Deltaproteobacteria,2MJ3W@213118|Desulfobacterales	28221|Deltaproteobacteria	C	TIGRFAM aconitate hydratase	-	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2763	Aconitase,Aconitase_C
HKD2_k127_4725201_0	1265505.ATUG01000002_gene1616	2.573e-199	632.0	COG0493@1|root,COG1148@1|root,COG0493@2|Bacteria,COG1148@2|Bacteria,1MU2H@1224|Proteobacteria,42M6X@68525|delta/epsilon subdivisions,2X6YD@28221|Deltaproteobacteria,2MIN8@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_20,Pyr_redox_2
HKD2_k127_4725201_1	1265505.ATUG01000002_gene1616	2.166e-57	202.0	COG0493@1|root,COG1148@1|root,COG0493@2|Bacteria,COG1148@2|Bacteria,1MU2H@1224|Proteobacteria,42M6X@68525|delta/epsilon subdivisions,2X6YD@28221|Deltaproteobacteria,2MIN8@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_20,Pyr_redox_2
HKD2_k127_4725201_2	1265505.ATUG01000002_gene1615	1.422e-07	54.0	COG0247@1|root,COG1150@1|root,COG0247@2|Bacteria,COG1150@2|Bacteria,1MUMH@1224|Proteobacteria,42N5J@68525|delta/epsilon subdivisions,2WJ6B@28221|Deltaproteobacteria,2MJHX@213118|Desulfobacterales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8
HKD2_k127_4747488_9	1121403.AUCV01000020_gene3118	2.565e-48	173.0	COG1899@1|root,COG1899@2|Bacteria,1R3WQ@1224|Proteobacteria,42M57@68525|delta/epsilon subdivisions,2WJ6N@28221|Deltaproteobacteria,2MHW7@213118|Desulfobacterales	28221|Deltaproteobacteria	O	peptidyl-lysine modification to peptidyl-hypusine	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4747488_5	589865.DaAHT2_0535	1.074e-125	409.0	COG0181@1|root,COG0181@2|Bacteria,1MU56@1224|Proteobacteria,42M84@68525|delta/epsilon subdivisions,2WJ5V@28221|Deltaproteobacteria,2MISN@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps	hemC	GO:0003674,GO:0003824,GO:0004418,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.61	ko:K01749	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00084	RC02317	ko00000,ko00001,ko00002,ko01000	-	-	-	Porphobil_deam,Porphobil_deamC
HKD2_k127_4747488_1	1121403.AUCV01000020_gene3121	6.933e-235	749.0	COG0007@1|root,COG1587@1|root,COG0007@2|Bacteria,COG1587@2|Bacteria,1MUI0@1224|Proteobacteria,42MCB@68525|delta/epsilon subdivisions,2WIRJ@28221|Deltaproteobacteria,2MISA@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Belongs to the precorrin methyltransferase family	hemD	-	1.3.1.76,2.1.1.107,4.2.1.75,4.99.1.4	ko:K02302,ko:K02303,ko:K13542	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02864,R03165,R03194,R03947	RC00003,RC00871,RC01012,RC01034,RC01861	ko00000,ko00001,ko00002,ko01000	-	-	-	HEM4,TP_methylase
HKD2_k127_4747488_11	1121451.DESAM_10053	2.055e-28	121.0	2CGNA@1|root,3301B@2|Bacteria,1N74P@1224|Proteobacteria,42VID@68525|delta/epsilon subdivisions,2WRHN@28221|Deltaproteobacteria,2MD48@213115|Desulfovibrionales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Yippee-Mis18
HKD2_k127_4747488_7	269799.Gmet_2955	1.196e-76	262.0	COG0500@1|root,COG0500@2|Bacteria,1RDRV@1224|Proteobacteria,43C47@68525|delta/epsilon subdivisions,2WV4E@28221|Deltaproteobacteria	28221|Deltaproteobacteria	Q	Tellurite resistance protein TehB	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
HKD2_k127_4747488_0	1232437.KL662020_gene792	2.219e-247	772.0	COG0374@1|root,COG0374@2|Bacteria,1MWFJ@1224|Proteobacteria,42M4S@68525|delta/epsilon subdivisions,2WJQS@28221|Deltaproteobacteria,2MI12@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Belongs to the NiFe NiFeSe hydrogenase large subunit family	-	-	1.12.99.6	ko:K06281	ko00633,ko01120,map00633,map01120	-	R08034	RC00250	ko00000,ko00001,ko01000	-	-	-	NiFeSe_Hases
HKD2_k127_4747488_4	589865.DaAHT2_0519	8.136e-136	443.0	COG1740@1|root,COG1740@2|Bacteria,1MWAC@1224|Proteobacteria,42Q7T@68525|delta/epsilon subdivisions,2WJ26@28221|Deltaproteobacteria,2MJ52@213118|Desulfobacterales	28221|Deltaproteobacteria	C	NiFe/NiFeSe hydrogenase small subunit C-terminal	-	-	1.12.99.6	ko:K06282	ko00633,ko01120,map00633,map01120	-	R08034	RC00250	ko00000,ko00001,ko01000	-	-	-	NiFe_hyd_SSU_C,Oxidored_q6,UCR_Fe-S_N
HKD2_k127_4747488_8	1380394.JADL01000011_gene3850	1.388e-76	280.0	COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2TQR7@28211|Alphaproteobacteria,2JQ44@204441|Rhodospirillales	204441|Rhodospirillales	T	methyl-accepting chemotaxis protein	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	HAMP,MCPsignal,sCache_2
HKD2_k127_4747488_2	1121405.dsmv_1315	1.172e-166	536.0	COG1159@1|root,COG1159@2|Bacteria,1QW17@1224|Proteobacteria,42MZH@68525|delta/epsilon subdivisions,2WKAE@28221|Deltaproteobacteria,2MHS2@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF3482)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3482,MMR_HSR1
HKD2_k127_4747488_6	1121405.dsmv_1316	2.888e-102	354.0	2C6CZ@1|root,32R7W@2|Bacteria,1RH5F@1224|Proteobacteria,42NQC@68525|delta/epsilon subdivisions,2WMFH@28221|Deltaproteobacteria,2MIVU@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF2868)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2868
HKD2_k127_4747488_10	338966.Ppro_3114	6.141e-31	131.0	COG2979@1|root,COG2979@2|Bacteria,1R95E@1224|Proteobacteria,42WF3@68525|delta/epsilon subdivisions,2WS14@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Protein of unknown function (DUF533)	-	-	-	-	-	-	-	-	-	-	-	-	DUF533
HKD2_k127_4747488_3	631362.Thi970DRAFT_04876	4.84e-154	499.0	COG2013@1|root,COG2013@2|Bacteria,1NBBE@1224|Proteobacteria,1RZ6E@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	TIGRFAM TIGR00266 family protein	-	-	-	-	-	-	-	-	-	-	-	-	AIM24
HKD2_k127_4768933_9	1167006.UWK_02742	3.408e-74	251.0	COG0563@1|root,COG0563@2|Bacteria,1MXCZ@1224|Proteobacteria,42M8E@68525|delta/epsilon subdivisions,2WJH0@28221|Deltaproteobacteria,2MNE9@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism	adk	GO:0003674,GO:0003824,GO:0004017,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901576	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ADK,ADK_lid
HKD2_k127_4768933_3	1121403.AUCV01000010_gene1341	4.613e-148	475.0	COG0152@1|root,COG0152@2|Bacteria,1MUR9@1224|Proteobacteria,42M8A@68525|delta/epsilon subdivisions,2WJY0@28221|Deltaproteobacteria,2MI2P@213118|Desulfobacterales	28221|Deltaproteobacteria	F	PFAM SAICAR synthetase	purC	GO:0003674,GO:0003824,GO:0004639,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.2.6	ko:K01923	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04591	RC00064,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	SAICAR_synt
HKD2_k127_4768933_19	189426.PODO_27055	1.106e-05	55.0	COG0860@1|root,COG3103@1|root,COG0860@2|Bacteria,COG3103@2|Bacteria,1UYPW@1239|Firmicutes,4HBVT@91061|Bacilli,26UYQ@186822|Paenibacillaceae	91061|Bacilli	MT	Ami_3	-	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	Amidase_3,SH3_3
HKD2_k127_4768933_15	1167006.UWK_00724	6.933e-36	147.0	COG0457@1|root,COG0457@2|Bacteria	1167006.UWK_00724|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4768933_5	1167006.UWK_01486	1.645e-110	370.0	COG0701@1|root,COG0701@2|Bacteria,1MUN8@1224|Proteobacteria,42NHE@68525|delta/epsilon subdivisions,2WJPP@28221|Deltaproteobacteria,2MIY7@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Predicted permease	-	-	-	ko:K07089	-	-	-	-	ko00000	-	-	-	ArsP_1
HKD2_k127_4768933_4	1167006.UWK_03441	2.55e-145	482.0	COG2989@1|root,COG2989@2|Bacteria,1MV14@1224|Proteobacteria,42MA2@68525|delta/epsilon subdivisions,2WKBM@28221|Deltaproteobacteria,2MHN3@213118|Desulfobacterales	28221|Deltaproteobacteria	S	L,D-transpeptidase catalytic domain	-	-	-	ko:K21470	-	-	-	-	ko00000,ko01002,ko01011	-	-	-	PG_binding_1,YkuD
HKD2_k127_4768933_16	1121403.AUCV01000008_gene1580	1.635e-29	121.0	COG1918@1|root,COG1918@2|Bacteria,1P8DM@1224|Proteobacteria,42V0G@68525|delta/epsilon subdivisions,2WR9N@28221|Deltaproteobacteria,2MM15@213118|Desulfobacterales	28221|Deltaproteobacteria	P	PFAM FeoA	-	-	-	ko:K04758	-	-	-	-	ko00000,ko02000	-	-	-	FeoA
HKD2_k127_4768933_1	1121403.AUCV01000006_gene407	5.027e-269	838.0	COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,42MSP@68525|delta/epsilon subdivisions,2WUHZ@28221|Deltaproteobacteria,2MPSX@213118|Desulfobacterales	28221|Deltaproteobacteria	E	LeuA allosteric (dimerisation) domain	leuA	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
HKD2_k127_4768933_13	42256.RradSPS_0326	1.855e-57	218.0	COG2931@1|root,COG5492@1|root,COG2931@2|Bacteria,COG5492@2|Bacteria	2|Bacteria	N	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	AIDA,DUF11,HemolysinCabind,VCBS
HKD2_k127_4768933_7	1121403.AUCV01000024_gene3420	4.749e-99	328.0	COG1145@1|root,COG1145@2|Bacteria,1PW12@1224|Proteobacteria,42MZ9@68525|delta/epsilon subdivisions,2WN0W@28221|Deltaproteobacteria,2MHYH@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_6
HKD2_k127_4768933_6	177437.HRM2_40610	9.408e-101	334.0	COG1418@1|root,COG1418@2|Bacteria,1R60M@1224|Proteobacteria,42NFJ@68525|delta/epsilon subdivisions,2WIJT@28221|Deltaproteobacteria,2MJ3J@213118|Desulfobacterales	28221|Deltaproteobacteria	S	PFAM metal-dependent phosphohydrolase HD sub	-	-	-	-	-	-	-	-	-	-	-	-	HD
HKD2_k127_4768933_0	1121403.AUCV01000024_gene3419	3.053e-277	862.0	COG0369@1|root,COG1151@2|Bacteria,1N88B@1224|Proteobacteria,42M2C@68525|delta/epsilon subdivisions,2WIVE@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O	hcp	-	1.7.99.1	ko:K05601	ko00910,map00910	-	R00143	RC02797	ko00000,ko00001,ko01000	-	-	-	Prismane
HKD2_k127_4768933_8	1167006.UWK_02340	1.267e-87	297.0	COG0664@1|root,COG0664@2|Bacteria,1MZZD@1224|Proteobacteria,42QUX@68525|delta/epsilon subdivisions,2WMWV@28221|Deltaproteobacteria,2MJH7@213118|Desulfobacterales	28221|Deltaproteobacteria	K	cyclic nucleotide-binding	fnr-1	-	-	ko:K01420,ko:K21563	-	-	-	-	ko00000,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
HKD2_k127_4768933_10	1384056.N787_06870	3.354e-69	249.0	COG3034@1|root,COG3034@2|Bacteria,1MXY6@1224|Proteobacteria,1RPXT@1236|Gammaproteobacteria,1X6MF@135614|Xanthomonadales	135614|Xanthomonadales	S	ErfK YbiS YcfS YnhG family protein	-	-	-	-	-	-	-	-	-	-	-	-	YkuD
HKD2_k127_4768933_2	1121403.AUCV01000024_gene3416	5.783e-149	483.0	COG0491@1|root,COG0607@1|root,COG0491@2|Bacteria,COG0607@2|Bacteria,1MUDN@1224|Proteobacteria,42N3H@68525|delta/epsilon subdivisions,2WJSC@28221|Deltaproteobacteria,2MPAJ@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Rhodanese Homology Domain	-	-	3.1.2.6	ko:K01069	ko00620,map00620	-	R01736	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	Lactamase_B,Rhodanese
HKD2_k127_4768933_17	1283300.ATXB01000001_gene946	2.881e-19	94.0	COG2913@1|root,COG2913@2|Bacteria,1QXS7@1224|Proteobacteria	1224|Proteobacteria	J	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4768933_12	1167006.UWK_01338	6.415e-65	229.0	COG1150@1|root,COG1150@2|Bacteria,1QWNB@1224|Proteobacteria,43BTA@68525|delta/epsilon subdivisions,2X741@28221|Deltaproteobacteria,2MI1V@213118|Desulfobacterales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_22
HKD2_k127_4804012_1	1167006.UWK_00423	3.577e-85	307.0	COG2982@1|root,COG2982@2|Bacteria,1NVUY@1224|Proteobacteria,42P4T@68525|delta/epsilon subdivisions,2WKBS@28221|Deltaproteobacteria,2MIDZ@213118|Desulfobacterales	28221|Deltaproteobacteria	M	AsmA-like C-terminal region	-	-	-	ko:K07289	-	-	-	-	ko00000	-	-	-	AsmA,AsmA_2
HKD2_k127_4804012_0	1167006.UWK_02354	5.232e-182	581.0	COG1696@1|root,COG1696@2|Bacteria,1MUXN@1224|Proteobacteria,42MIR@68525|delta/epsilon subdivisions,2WMEK@28221|Deltaproteobacteria,2MJC8@213118|Desulfobacterales	28221|Deltaproteobacteria	M	MBOAT, membrane-bound O-acyltransferase family	algI	-	-	ko:K19294	-	-	-	-	ko00000	-	-	-	MBOAT
HKD2_k127_4804012_2	1167006.UWK_02353	2.488e-60	220.0	COG0457@1|root,COG0457@2|Bacteria,1RIYN@1224|Proteobacteria,42T31@68525|delta/epsilon subdivisions,2WPYY@28221|Deltaproteobacteria,2MKKV@213118|Desulfobacterales	28221|Deltaproteobacteria	S	SGNH hydrolase-like domain, acetyltransferase AlgX	-	-	-	-	-	-	-	-	-	-	-	-	ALGX
HKD2_k127_4819268_4	292459.STH1761	7.031e-27	109.0	COG0225@1|root,COG0229@1|root,COG0225@2|Bacteria,COG0229@2|Bacteria,1TQ3E@1239|Firmicutes,247UT@186801|Clostridia	186801|Clostridia	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	msrA	-	1.8.4.11,1.8.4.12	ko:K07304,ko:K12267	-	-	-	-	ko00000,ko01000	-	-	-	PMSR,SelR
HKD2_k127_4819268_2	1121920.AUAU01000025_gene2340	3.893e-53	194.0	COG0607@1|root,COG2897@1|root,COG0607@2|Bacteria,COG2897@2|Bacteria	2|Bacteria	P	thiosulfate sulfurtransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
HKD2_k127_4819268_1	443144.GM21_1861	4.43e-75	259.0	COG0607@1|root,COG2897@1|root,COG0607@2|Bacteria,COG2897@2|Bacteria,1MU3V@1224|Proteobacteria,42NRF@68525|delta/epsilon subdivisions,2WJZ6@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	PFAM Rhodanese domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
HKD2_k127_4819268_3	522772.Dacet_2355	1.534e-46	176.0	COG1762@1|root,COG3311@1|root,COG1762@2|Bacteria,COG3311@2|Bacteria	2|Bacteria	K	DNA excision	-	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006810,GO:0008150,GO:0008643,GO:0009401,GO:0015144,GO:0015791,GO:0015796,GO:0015850,GO:0016020,GO:0016740,GO:0016772,GO:0016773,GO:0022804,GO:0022857,GO:0034219,GO:0044424,GO:0044444,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0090563,GO:0090584	2.7.1.200,2.7.1.202	ko:K02768,ko:K02769,ko:K02770,ko:K02773,ko:K02806,ko:K03491	ko00051,ko00052,ko01100,ko01120,ko02060,map00051,map00052,map01100,map01120,map02060	M00273,M00279	R03232,R05570	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000,ko03000	4.A.2.1,4.A.5.1	-	-	HTH_11,HTH_17,Mga,PRD,PTS_EIIA_2,PTS_IIB
HKD2_k127_4819268_0	1121918.ARWE01000001_gene400	1.139e-160	529.0	COG0651@1|root,COG0651@2|Bacteria,1MXRW@1224|Proteobacteria,42NFV@68525|delta/epsilon subdivisions,2WJZ0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	CP	PFAM NADH Ubiquinone plastoquinone (complex I)	-	-	-	ko:K12137	-	-	-	-	ko00000,ko01000	-	-	-	Proton_antipo_M,Proton_antipo_N
HKD2_k127_4831668_2	1121396.KB893066_gene1579	5.981e-93	318.0	COG0845@1|root,COG0845@2|Bacteria,1MXGH@1224|Proteobacteria,42M4G@68525|delta/epsilon subdivisions,2WKAK@28221|Deltaproteobacteria,2MHPS@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
HKD2_k127_4831668_1	1167006.UWK_01070	1.15e-128	429.0	COG1538@1|root,COG1538@2|Bacteria,1R8XP@1224|Proteobacteria,42QGI@68525|delta/epsilon subdivisions,2WJH9@28221|Deltaproteobacteria,2MJD1@213118|Desulfobacterales	28221|Deltaproteobacteria	MU	PFAM Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
HKD2_k127_4831668_0	1121403.AUCV01000012_gene4044	9.707e-172	551.0	COG1007@1|root,COG1007@2|Bacteria,1MV56@1224|Proteobacteria,42P7Z@68525|delta/epsilon subdivisions,2WKS0@28221|Deltaproteobacteria,2MIJK@213118|Desulfobacterales	28221|Deltaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoN	-	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
HKD2_k127_4831668_3	1121403.AUCV01000012_gene4043	0.0008989	42.0	COG1008@1|root,COG1008@2|Bacteria,1MV7V@1224|Proteobacteria,42NGD@68525|delta/epsilon subdivisions,2WJDC@28221|Deltaproteobacteria,2MJG3@213118|Desulfobacterales	28221|Deltaproteobacteria	C	TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain M	nuoM	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q5_N,Proton_antipo_M
HKD2_k127_4838357_7	1121403.AUCV01000039_gene4368	1.103e-75	263.0	COG1189@1|root,COG1189@2|Bacteria,1MWP5@1224|Proteobacteria,42R2J@68525|delta/epsilon subdivisions,2WIJ6@28221|Deltaproteobacteria,2MIMF@213118|Desulfobacterales	28221|Deltaproteobacteria	J	PFAM ribosomal RNA methyltransferase RrmJ FtsJ	tlyA	-	2.1.1.226,2.1.1.227	ko:K06442	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ,S4
HKD2_k127_4838357_9	1121403.AUCV01000039_gene4367	1.121e-69	249.0	COG1729@1|root,COG1729@2|Bacteria,1MUSV@1224|Proteobacteria,42P32@68525|delta/epsilon subdivisions,2WM9Q@28221|Deltaproteobacteria,2MISR@213118|Desulfobacterales	28221|Deltaproteobacteria	D	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division	cpoB	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_6
HKD2_k127_4838357_3	1121403.AUCV01000039_gene4366	3.142e-151	489.0	COG0823@1|root,COG0823@2|Bacteria,1MV09@1224|Proteobacteria,42PHP@68525|delta/epsilon subdivisions,2WIXN@28221|Deltaproteobacteria,2MHR4@213118|Desulfobacterales	28221|Deltaproteobacteria	U	Involved in the TonB-independent uptake of proteins	tolB	GO:0003674,GO:0005215,GO:0006810,GO:0008150,GO:0019534,GO:0022857,GO:0051179,GO:0051234,GO:0055085,GO:1901998	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40,TolB_N
HKD2_k127_4838357_13	1121403.AUCV01000039_gene4365	8.701e-42	166.0	COG0810@1|root,COG0810@2|Bacteria,1MZ9F@1224|Proteobacteria,42XAV@68525|delta/epsilon subdivisions,2WSJJ@28221|Deltaproteobacteria,2MK1A@213118|Desulfobacterales	28221|Deltaproteobacteria	M	TonB C terminal	-	-	-	ko:K03646,ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1,2.C.1.2	-	-	TonB_2
HKD2_k127_4838357_10	1121403.AUCV01000039_gene4364	1.128e-49	180.0	COG0848@1|root,COG0848@2|Bacteria,1MZ6M@1224|Proteobacteria,42U00@68525|delta/epsilon subdivisions,2WQD4@28221|Deltaproteobacteria,2MKKC@213118|Desulfobacterales	28221|Deltaproteobacteria	U	PFAM Biopolymer transport protein ExbD TolR	tolR	-	-	ko:K03560	-	-	-	-	ko00000,ko02000	1.A.30.2.2	-	-	ExbD
HKD2_k127_4838357_6	1121403.AUCV01000039_gene4363	3.493e-83	282.0	COG0811@1|root,COG0811@2|Bacteria,1NCWW@1224|Proteobacteria,42PKF@68525|delta/epsilon subdivisions,2WNQ4@28221|Deltaproteobacteria,2MHWF@213118|Desulfobacterales	28221|Deltaproteobacteria	U	PFAM MotA TolQ ExbB proton channel	tolQ	-	-	ko:K03561,ko:K03562	ko01120,map01120	-	-	-	ko00000,ko02000	1.A.30.2.1,1.A.30.2.2	-	-	MotA_ExbB
HKD2_k127_4838357_8	1121403.AUCV01000039_gene4362	2.288e-74	256.0	COG0492@1|root,COG0492@2|Bacteria,1R82E@1224|Proteobacteria,42PSM@68525|delta/epsilon subdivisions,2WJYX@28221|Deltaproteobacteria,2MN1E@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_3
HKD2_k127_4838357_12	1121403.AUCV01000039_gene4362	9.485e-44	161.0	COG0492@1|root,COG0492@2|Bacteria,1R82E@1224|Proteobacteria,42PSM@68525|delta/epsilon subdivisions,2WJYX@28221|Deltaproteobacteria,2MN1E@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_3
HKD2_k127_4838357_1	177439.DP0577	3.209e-220	707.0	COG0068@1|root,COG0068@2|Bacteria,1MVP8@1224|Proteobacteria,42M3G@68525|delta/epsilon subdivisions,2WJ51@28221|Deltaproteobacteria,2MIT1@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide	hypF	-	-	ko:K04656	-	-	-	-	ko00000	-	-	iAF987.Gmet_0119	Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF
HKD2_k127_4838357_14	1255043.TVNIR_2039	7.591e-08	57.0	COG0298@1|root,COG0298@2|Bacteria,1N76Y@1224|Proteobacteria,1SCGX@1236|Gammaproteobacteria,1WZ96@135613|Chromatiales	135613|Chromatiales	O	TIGRFAM hydrogenase assembly chaperone hypC hupF	-	-	-	ko:K04653	-	-	-	-	ko00000	-	-	-	HupF_HypC
HKD2_k127_4838357_4	177439.DP0579	8.525e-131	428.0	COG0409@1|root,COG0409@2|Bacteria,1MU1F@1224|Proteobacteria,42M6R@68525|delta/epsilon subdivisions,2WJDQ@28221|Deltaproteobacteria,2MIT3@213118|Desulfobacterales	28221|Deltaproteobacteria	O	hydrogenase expression formation protein HypD	hypD	-	-	ko:K04654	-	-	-	-	ko00000	-	-	iAF987.Gmet_0117	HypD
HKD2_k127_4838357_5	1167006.UWK_01162	1.156e-121	402.0	COG0309@1|root,COG0309@2|Bacteria,1MVCC@1224|Proteobacteria,42M3M@68525|delta/epsilon subdivisions,2WJ8B@28221|Deltaproteobacteria,2MHUA@213118|Desulfobacterales	28221|Deltaproteobacteria	O	hydrogenase expression formation protein HypE	hypE	-	-	ko:K04655	-	-	-	-	ko00000	-	-	-	AIRS,AIRS_C
HKD2_k127_4838357_2	1167006.UWK_01156	1.451e-168	537.0	COG1740@1|root,COG1740@2|Bacteria,1MWAC@1224|Proteobacteria,42MI0@68525|delta/epsilon subdivisions,2WIW4@28221|Deltaproteobacteria,2MJ8Z@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Hydrogenase (NiFe) small subunit HydA	hynB	-	1.12.2.1,1.12.5.1,1.12.99.6	ko:K05927,ko:K06282,ko:K18008	ko00633,ko01120,map00633,map01120	-	R08034	RC00250	ko00000,ko00001,ko01000	-	-	-	NiFe_hyd_SSU_C,Oxidored_q6,TAT_signal
HKD2_k127_4838357_0	1167006.UWK_01157	8.382e-309	952.0	COG0374@1|root,COG0374@2|Bacteria,1MWFJ@1224|Proteobacteria,42M4S@68525|delta/epsilon subdivisions,2WJQS@28221|Deltaproteobacteria,2MI12@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Belongs to the NiFe NiFeSe hydrogenase large subunit family	hynA	-	1.12.2.1,1.12.5.1,1.12.99.6	ko:K00437,ko:K05922,ko:K06281	ko00633,ko01120,map00633,map01120	-	R08034	RC00250	ko00000,ko00001,ko01000	-	-	-	NiFeSe_Hases
HKD2_k127_4838357_11	648996.Theam_1123	3.427e-44	164.0	COG1969@1|root,COG1969@2|Bacteria,2G49X@200783|Aquificae	200783|Aquificae	C	Ni Fe-hydrogenase, b-type cytochrome subunit	-	-	-	ko:K03620	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	Ni_hydr_CYTB
HKD2_k127_4852203_1	589865.DaAHT2_0217	2.737e-87	294.0	COG1611@1|root,COG1611@2|Bacteria,1MU6N@1224|Proteobacteria,42P56@68525|delta/epsilon subdivisions,2WK5J@28221|Deltaproteobacteria,2MHV0@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Belongs to the LOG family	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
HKD2_k127_4852203_2	589865.DaAHT2_0216	2.916e-83	304.0	COG0457@1|root,COG2199@1|root,COG0457@2|Bacteria,COG2199@2|Bacteria,1RDNA@1224|Proteobacteria,42Q5I@68525|delta/epsilon subdivisions,2WIX0@28221|Deltaproteobacteria,2MJTP@213118|Desulfobacterales	28221|Deltaproteobacteria	T	TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,TPR_11,TPR_16,TPR_19,TPR_2,TPR_4,TPR_7,TPR_8
HKD2_k127_4852203_0	589865.DaAHT2_0215	2.884e-174	559.0	COG1921@1|root,COG1921@2|Bacteria,1MWXI@1224|Proteobacteria,42MU7@68525|delta/epsilon subdivisions,2WJFQ@28221|Deltaproteobacteria,2MIIC@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis	selA	GO:0003674,GO:0003824,GO:0004125,GO:0006139,GO:0006399,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016740,GO:0016785,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034654,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097056,GO:0140098,GO:0140101,GO:1901360,GO:1901362,GO:1901576	2.9.1.1	ko:K01042	ko00450,ko00970,map00450,map00970	-	R08219	RC01246	ko00000,ko00001,ko01000	-	-	-	Se-cys_synth_N,SelA
HKD2_k127_4852203_3	1123489.AUAN01000022_gene40	1.301e-06	51.0	2ERMT@1|root,33J79@2|Bacteria,1VKZE@1239|Firmicutes	1239|Firmicutes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4873761_1	1096546.WYO_3811	6.603e-113	374.0	COG0444@1|root,COG0444@2|Bacteria,1R4KB@1224|Proteobacteria,2TR0J@28211|Alphaproteobacteria,1JR8B@119045|Methylobacteriaceae	28211|Alphaproteobacteria	EP	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
HKD2_k127_4873761_0	215803.DB30_0768	1.392e-116	384.0	COG4608@1|root,COG4608@2|Bacteria,1NU4K@1224|Proteobacteria,42TDH@68525|delta/epsilon subdivisions,2WIQT@28221|Deltaproteobacteria,2YU5K@29|Myxococcales	28221|Deltaproteobacteria	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02032,ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
HKD2_k127_4873761_2	644282.Deba_1326	2.283e-24	105.0	COG0413@1|root,COG0413@2|Bacteria,1MU3B@1224|Proteobacteria,42MES@68525|delta/epsilon subdivisions,2WIQK@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate	panB	-	2.1.2.11	ko:K00606	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R01226	RC00022,RC00200	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_transf
HKD2_k127_487489_7	177439.DP0996	3.25e-39	151.0	COG0760@1|root,COG0760@2|Bacteria,1MWV0@1224|Proteobacteria,42MPK@68525|delta/epsilon subdivisions,2WJM1@28221|Deltaproteobacteria,2MHM6@213118|Desulfobacterales	28221|Deltaproteobacteria	O	PFAM PpiC-type peptidyl-prolyl cis-trans isomerase	nifM	-	5.2.1.8	ko:K03770	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_2,Rotamase_3,SurA_N_3
HKD2_k127_487489_5	1121403.AUCV01000034_gene3854	1.027e-57	202.0	COG2920@1|root,COG2920@2|Bacteria,1RGVG@1224|Proteobacteria,42SN5@68525|delta/epsilon subdivisions,2WP28@28221|Deltaproteobacteria,2MK45@213118|Desulfobacterales	28221|Deltaproteobacteria	P	TIGRFAM sulfur relay protein, TusE DsrC DsvC family	dsrC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K11179	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	DsrC
HKD2_k127_487489_3	589865.DaAHT2_2417	8.498e-76	267.0	COG0189@1|root,COG0189@2|Bacteria,1NWJ2@1224|Proteobacteria,4302E@68525|delta/epsilon subdivisions,2WVAQ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	HJ	ligase activity	-	-	-	ko:K05844	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	RimK
HKD2_k127_487489_9	266117.Rxyl_0794	7.891e-21	100.0	COG1254@1|root,COG1254@2|Bacteria,2IT6J@201174|Actinobacteria,4CTJ9@84995|Rubrobacteria	84995|Rubrobacteria	C	Acylphosphatase	-	-	3.6.1.7	ko:K01512	ko00620,ko00627,ko01120,map00620,map00627,map01120	-	R00317,R01421,R01515	RC00043	ko00000,ko00001,ko01000	-	-	-	Acylphosphatase
HKD2_k127_487489_0	420246.GTNG_0256	3.243e-197	635.0	COG0272@1|root,COG0272@2|Bacteria,1TPQ3@1239|Firmicutes,4HA1D@91061|Bacilli,1WEJD@129337|Geobacillus	91061|Bacilli	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5
HKD2_k127_487489_10	1121403.AUCV01000034_gene3858	4.637e-16	79.0	COG1942@1|root,COG1942@2|Bacteria,1NNJI@1224|Proteobacteria	1224|Proteobacteria	S	Tautomerase enzyme	-	-	5.3.2.6	ko:K01821	ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00362,map00621,map00622,map01100,map01120,map01220	M00569	R03966,R05389	RC01040,RC01355	ko00000,ko00001,ko00002,ko01000	-	-	-	Tautomerase
HKD2_k127_487489_2	338963.Pcar_1245	6.495e-94	319.0	COG0697@1|root,COG0697@2|Bacteria	2|Bacteria	EG	spore germination	CP_1064	-	-	-	-	-	-	-	-	-	-	-	EamA
HKD2_k127_487489_4	1304885.AUEY01000006_gene755	5.048e-62	220.0	COG0639@1|root,COG0639@2|Bacteria,1RD8M@1224|Proteobacteria,42RQP@68525|delta/epsilon subdivisions,2WNQ7@28221|Deltaproteobacteria,2MK7M@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Calcineurin-like phosphoesterase	-	-	3.1.3.16	ko:K07313	-	-	-	-	ko00000,ko01000	-	-	-	Metallophos,Metallophos_2
HKD2_k127_487489_1	289377.HL41_08205	9.942e-126	416.0	COG1032@1|root,COG1032@2|Bacteria,2GHII@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	C	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
HKD2_k127_487489_6	550540.Fbal_2989	5.323e-41	158.0	arCOG10218@1|root,320QR@2|Bacteria,1N5AN@1224|Proteobacteria	1224|Proteobacteria	C	Putative redox-active protein (C_GCAxxG_C_C)	-	-	-	-	-	-	-	-	-	-	-	-	C_GCAxxG_C_C
HKD2_k127_487489_12	635013.TherJR_0509	0.0008714	46.0	arCOG10218@1|root,320QR@2|Bacteria,1V2IY@1239|Firmicutes,24GEB@186801|Clostridia,2645G@186807|Peptococcaceae	186801|Clostridia	C	Putative redox-active protein (C_GCAxxG_C_C)	-	-	-	-	-	-	-	-	-	-	-	-	C_GCAxxG_C_C
HKD2_k127_4883813_2	927658.AJUM01000043_gene792	3.159e-37	157.0	COG5107@1|root,COG5107@2|Bacteria,4NEPG@976|Bacteroidetes,2FNHC@200643|Bacteroidia,3XIXI@558415|Marinilabiliaceae	976|Bacteroidetes	A	Domain of Unknown Function (DUF349)	-	-	-	-	-	-	-	-	-	-	-	-	DUF349
HKD2_k127_4883813_0	589865.DaAHT2_1025	6.411e-127	410.0	COG1148@1|root,COG1148@2|Bacteria,1RB0H@1224|Proteobacteria,42QQV@68525|delta/epsilon subdivisions,2WN7E@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
HKD2_k127_4883813_3	316067.Geob_2058	0.0002688	47.0	COG0500@1|root,COG2226@2|Bacteria,1MXP4@1224|Proteobacteria	1224|Proteobacteria	Q	Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25,Methyltransf_31,Ubie_methyltran
HKD2_k127_4883813_1	1232410.KI421428_gene1003	5.012e-75	259.0	COG2199@1|root,COG2199@2|Bacteria,1R80Z@1224|Proteobacteria,42RXX@68525|delta/epsilon subdivisions,2WNME@28221|Deltaproteobacteria,43TKF@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
HKD2_k127_488522_1	1167006.UWK_02365	1.949e-54	201.0	COG1216@1|root,COG1216@2|Bacteria,1QUMD@1224|Proteobacteria,42YHP@68525|delta/epsilon subdivisions,2X5FF@28221|Deltaproteobacteria,2MQ3A@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HKD2_k127_488522_0	1232437.KL662006_gene4462	2.193e-74	260.0	COG0438@1|root,COG0438@2|Bacteria,1Q3UV@1224|Proteobacteria,439NZ@68525|delta/epsilon subdivisions,2X50B@28221|Deltaproteobacteria,2MMJG@213118|Desulfobacterales	28221|Deltaproteobacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4927957_1	439235.Dalk_4733	4.852e-29	119.0	COG4273@1|root,COG4273@2|Bacteria,1MZN7@1224|Proteobacteria,42XSN@68525|delta/epsilon subdivisions,2WT4W@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Domain of unknown function (DUF2703)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2703
HKD2_k127_4927957_0	690850.Desaf_2160	2.477e-192	610.0	COG0701@1|root,COG0701@2|Bacteria,1MUN8@1224|Proteobacteria,42N6E@68525|delta/epsilon subdivisions,2WJXG@28221|Deltaproteobacteria,2M9VF@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Predicted permease	-	-	-	ko:K07089	-	-	-	-	ko00000	-	-	-	ArsP_1
HKD2_k127_4952354_4	1121918.ARWE01000001_gene404	7.573e-15	88.0	COG0651@1|root,COG0651@2|Bacteria,1MVBA@1224|Proteobacteria,42MG7@68525|delta/epsilon subdivisions,2WIRA@28221|Deltaproteobacteria	28221|Deltaproteobacteria	CP	PFAM NADH Ubiquinone plastoquinone (complex I)	-	-	-	ko:K12141	-	-	-	-	ko00000,ko01000	-	-	-	Proton_antipo_M
HKD2_k127_4952354_2	1121918.ARWE01000001_gene405	4.031e-101	333.0	COG4237@1|root,COG4237@2|Bacteria,1PKAY@1224|Proteobacteria,42PFV@68525|delta/epsilon subdivisions	1224|Proteobacteria	C	Ni-Fe hydrogenase, membrane subunit HyfE	-	-	-	ko:K12140	-	-	-	-	ko00000,ko01000	-	-	-	-
HKD2_k127_4952354_1	1121918.ARWE01000001_gene406	2.501e-131	440.0	COG0650@1|root,COG0650@2|Bacteria,1MXV5@1224|Proteobacteria,42NHI@68525|delta/epsilon subdivisions,2WJ3D@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	NADH dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	NADHdh
HKD2_k127_4952354_0	1121918.ARWE01000001_gene407	3.735e-297	924.0	COG0651@1|root,COG0651@2|Bacteria,1MV6V@1224|Proteobacteria,42MSA@68525|delta/epsilon subdivisions,2WIS1@28221|Deltaproteobacteria	28221|Deltaproteobacteria	CP	PFAM NADH Ubiquinone plastoquinone (complex I)	-	-	-	ko:K05568,ko:K12137	-	-	-	-	ko00000,ko01000,ko02000	2.A.63.1,2.A.63.2	-	-	Proton_antipo_M
HKD2_k127_4952354_3	1232410.KI421427_gene1299	9.44e-26	111.0	COG0651@1|root,COG0651@2|Bacteria,1MXRW@1224|Proteobacteria,42NFV@68525|delta/epsilon subdivisions,2WJZ0@28221|Deltaproteobacteria,43T2H@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	PFAM NADH Ubiquinone plastoquinone (complex I)	ehrA-2	-	-	ko:K12137	-	-	-	-	ko00000,ko01000	-	-	-	Proton_antipo_M,Proton_antipo_N
HKD2_k127_4998944_0	1167006.UWK_01068	0.0	1606.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MQ0@68525|delta/epsilon subdivisions,2WISW@28221|Deltaproteobacteria,2MIUG@213118|Desulfobacterales	28221|Deltaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
HKD2_k127_4998944_1	1123508.JH636439_gene1132	5.088e-100	336.0	COG1520@1|root,COG2373@1|root,COG2931@1|root,COG3386@1|root,COG4932@1|root,COG1520@2|Bacteria,COG2373@2|Bacteria,COG2931@2|Bacteria,COG3386@2|Bacteria,COG4932@2|Bacteria,2J4W7@203682|Planctomycetes	2|Bacteria	G	Pkd domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CHRD,CHU_C,DUF11,DUF4347,SdrD_B
HKD2_k127_5019874_3	471854.Dfer_2050	1.278e-28	130.0	COG2831@1|root,COG2931@1|root,COG2831@2|Bacteria,COG2931@2|Bacteria,4NKIR@976|Bacteroidetes,47S7V@768503|Cytophagia	976|Bacteroidetes	Q	SMART Integrin alpha beta-propellor repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,FG-GAP,HYR,VCBS
HKD2_k127_5019874_1	1265505.ATUG01000002_gene1615	4.253e-256	812.0	COG0247@1|root,COG1150@1|root,COG0247@2|Bacteria,COG1150@2|Bacteria,1MUMH@1224|Proteobacteria,42N5J@68525|delta/epsilon subdivisions,2WJ6B@28221|Deltaproteobacteria,2MJHX@213118|Desulfobacterales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8
HKD2_k127_5019874_0	1265505.ATUG01000002_gene1616	0.0	1538.0	COG0493@1|root,COG1148@1|root,COG0493@2|Bacteria,COG1148@2|Bacteria,1MU2H@1224|Proteobacteria,42M6X@68525|delta/epsilon subdivisions,2X6YD@28221|Deltaproteobacteria,2MIN8@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_20,Pyr_redox_2
HKD2_k127_5019874_2	1265505.ATUG01000002_gene1617	5.613e-57	201.0	COG1908@1|root,COG1908@2|Bacteria,1RCZY@1224|Proteobacteria,42RK0@68525|delta/epsilon subdivisions,2WNZZ@28221|Deltaproteobacteria,2MK05@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Methyl-viologen-reducing hydrogenase, delta subunit	-	-	1.8.98.5,1.8.98.6	ko:K14127	ko00680,map00680	-	R00019,R11943,R11944	RC00011	ko00000,ko00001,ko01000	-	-	-	FlpD
HKD2_k127_5040937_5	1121878.AUGL01000013_gene2943	5.449e-20	103.0	COG2067@1|root,COG3637@1|root,COG2067@2|Bacteria,COG3637@2|Bacteria,1PA8J@1224|Proteobacteria,1S0HC@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Putative outer membrane beta-barrel porin, MtrB/PioB	-	-	-	-	-	-	-	-	-	-	-	-	MtrB_PioB
HKD2_k127_5040937_4	709986.Deima_3294	4.508e-32	130.0	COG0784@1|root,COG0784@2|Bacteria,1WMM2@1297|Deinococcus-Thermus	2|Bacteria	T	PFAM response regulator receiver	rcp1	-	-	ko:K02485,ko:K11355	ko02020,map02020	M00510	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg
HKD2_k127_5040937_3	1121403.AUCV01000019_gene3312	1.672e-43	166.0	COG0745@1|root,COG0745@2|Bacteria	1121403.AUCV01000019_gene3312|-	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5040937_0	1121403.AUCV01000019_gene3311	9.826e-154	500.0	COG2204@1|root,COG2204@2|Bacteria,1MVWX@1224|Proteobacteria,42MIB@68525|delta/epsilon subdivisions,2WJQK@28221|Deltaproteobacteria,2MHU2@213118|Desulfobacterales	28221|Deltaproteobacteria	T	sigma54 specific, transcriptional regulator, Fis family	-	-	-	ko:K02481	-	-	-	-	ko00000,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD2_k127_5040937_2	1166018.FAES_5140	6.101e-55	196.0	COG0698@1|root,COG0698@2|Bacteria,4NNSU@976|Bacteroidetes,47PQK@768503|Cytophagia	976|Bacteroidetes	G	Ribose 5-phosphate isomerase	rpiB	-	5.3.1.6	ko:K01808	ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01056,R09030	RC00376,RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	LacAB_rpiB
HKD2_k127_5040937_1	589865.DaAHT2_0413	2.899e-92	307.0	COG0655@1|root,COG0655@2|Bacteria,1MW7N@1224|Proteobacteria,42PF5@68525|delta/epsilon subdivisions,2WMD8@28221|Deltaproteobacteria,2MIX9@213118|Desulfobacterales	28221|Deltaproteobacteria	C	NADPH-dependent FMN reductase	wrbA	GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0055114	1.6.5.2	ko:K03809	ko00130,ko01110,map00130,map01110	-	R02964,R03643,R03816	RC00819	ko00000,ko00001,ko01000	-	-	iAF987.Gmet_0771	FMN_red
HKD2_k127_5046697_5	1265505.ATUG01000002_gene1588	3.488e-112	366.0	COG0709@1|root,COG0709@2|Bacteria,1MWFG@1224|Proteobacteria,42MC3@68525|delta/epsilon subdivisions,2WK3M@28221|Deltaproteobacteria,2MN2H@213118|Desulfobacterales	28221|Deltaproteobacteria	E	AIR synthase related protein, N-terminal domain	selD	-	2.7.9.3	ko:K01008	ko00450,ko01100,map00450,map01100	-	R03595	RC00002,RC02878	ko00000,ko00001,ko01000,ko03016	-	-	-	AIRS,AIRS_C
HKD2_k127_5046697_0	1121403.AUCV01000008_gene1617	5.363e-201	637.0	COG1220@1|root,COG1220@2|Bacteria,1MVK9@1224|Proteobacteria,42M48@68525|delta/epsilon subdivisions,2WISV@28221|Deltaproteobacteria,2MIBH@213118|Desulfobacterales	28221|Deltaproteobacteria	O	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis	hslU	-	-	ko:K03667	-	-	-	-	ko00000,ko03110	-	-	-	AAA_2,ClpB_D2-small
HKD2_k127_5046697_6	1167006.UWK_02518	9.44e-80	269.0	COG5405@1|root,COG5405@2|Bacteria,1MVF2@1224|Proteobacteria,42MEH@68525|delta/epsilon subdivisions,2WMSC@28221|Deltaproteobacteria,2MJC6@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery	hslV	-	3.4.25.2	ko:K01419	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Proteasome
HKD2_k127_5046697_4	1167006.UWK_02517	1.579e-114	376.0	COG4974@1|root,COG4974@2|Bacteria,1QU6A@1224|Proteobacteria,42Q4U@68525|delta/epsilon subdivisions,2WJ08@28221|Deltaproteobacteria,2MI4K@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Belongs to the 'phage' integrase family. XerC subfamily	xerC	-	-	ko:K03733,ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
HKD2_k127_5046697_2	589865.DaAHT2_1047	9.683e-174	553.0	COG1690@1|root,COG1690@2|Bacteria,1MUHA@1224|Proteobacteria,42MZN@68525|delta/epsilon subdivisions,2WJGK@28221|Deltaproteobacteria,2MHPF@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Belongs to the RtcB family	rtcB	-	6.5.1.3	ko:K14415	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RtcB
HKD2_k127_5046697_8	1041138.KB890256_gene3668	5.103e-40	154.0	COG1595@1|root,COG1595@2|Bacteria,1RKMN@1224|Proteobacteria,2U9GS@28211|Alphaproteobacteria,4BDTH@82115|Rhizobiaceae	28211|Alphaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	algU	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD2_k127_5046697_1	1134912.AJTV01000053_gene3694	8.484e-188	610.0	COG2304@1|root,COG2304@2|Bacteria,1MUTS@1224|Proteobacteria,2TSQU@28211|Alphaproteobacteria,36ZIN@31993|Methylocystaceae	28211|Alphaproteobacteria	S	von Willebrand factor type A domain	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	DUF3520,VWA,vWF_A
HKD2_k127_5046697_3	177439.DP0081	8.247e-149	482.0	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,42N2U@68525|delta/epsilon subdivisions,2WJRR@28221|Deltaproteobacteria,2MI9B@213118|Desulfobacterales	28221|Deltaproteobacteria	V	ABC transporter transmembrane region	-	-	-	ko:K06147,ko:K18890	ko02010,map02010	M00707	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.106,3.A.1.106.13,3.A.1.106.5,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
HKD2_k127_5062551_2	1121403.AUCV01000020_gene3128	5.532e-25	120.0	COG1413@1|root,COG1413@2|Bacteria	2|Bacteria	C	deoxyhypusine monooxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,HEAT_PBS,Nfu_N
HKD2_k127_5062551_0	1167006.UWK_02891	5.241e-149	479.0	COG0820@1|root,COG0820@2|Bacteria,1MUYK@1224|Proteobacteria,42N69@68525|delta/epsilon subdivisions,2WIUJ@28221|Deltaproteobacteria,2MJ4T@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs	rlmN	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140101,GO:0140102,GO:1901360	2.1.1.192	ko:K06941	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Fer4_14,Radical_SAM
HKD2_k127_5062551_1	589865.DaAHT2_0796	7.619e-98	327.0	COG1032@1|root,COG1032@2|Bacteria,1P9J0@1224|Proteobacteria,42MWG@68525|delta/epsilon subdivisions,2WIV5@28221|Deltaproteobacteria,2MI1A@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM Radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
HKD2_k127_5073784_1	631362.Thi970DRAFT_01102	3.552e-54	202.0	2CFYY@1|root,3255I@2|Bacteria,1NVZK@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5073784_0	202954.BBNK01000011_gene989	2.457e-96	321.0	COG4420@1|root,COG4420@2|Bacteria,1RIDY@1224|Proteobacteria,1S3IM@1236|Gammaproteobacteria,3NST6@468|Moraxellaceae	1236|Gammaproteobacteria	S	Protein of unknown function (DUF1003)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1003
HKD2_k127_5073784_2	1123325.JHUV01000010_gene1181	7.929e-14	75.0	COG1566@1|root,COG1566@2|Bacteria,2G45H@200783|Aquificae	200783|Aquificae	V	secretion protein HlyD family	-	-	-	ko:K03543	-	M00701	-	-	ko00000,ko00002,ko02000	8.A.1.1	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
HKD2_k127_5081738_0	1167006.UWK_01905	1.799e-205	646.0	COG0542@1|root,COG0542@2|Bacteria,1MURH@1224|Proteobacteria,42M9S@68525|delta/epsilon subdivisions,2WJSZ@28221|Deltaproteobacteria,2MHW3@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpB	-	-	ko:K03695	ko04213,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
HKD2_k127_5081738_5	1121403.AUCV01000020_gene3151	4.554e-28	114.0	COG0316@1|root,COG0316@2|Bacteria,1R3FD@1224|Proteobacteria,43DK2@68525|delta/epsilon subdivisions,2X8RA@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Belongs to the HesB IscA family	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5081738_8	589865.DaAHT2_1264	1.098e-05	48.0	COG0316@1|root,COG0316@2|Bacteria,1N8FK@1224|Proteobacteria,42VBF@68525|delta/epsilon subdivisions,2WR7Y@28221|Deltaproteobacteria,2MKZ6@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Belongs to the HesB IscA family	-	-	-	-	-	-	-	-	-	-	-	-	Fe-S_biosyn
HKD2_k127_5081738_3	644282.Deba_2409	3.655e-80	272.0	COG2231@1|root,COG2231@2|Bacteria,1RDJ8@1224|Proteobacteria,42QYA@68525|delta/epsilon subdivisions,2WNGC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	PFAM HhH-GPD family protein	nth	-	-	ko:K07457	-	-	-	-	ko00000	-	-	-	HhH-GPD
HKD2_k127_5081738_1	941824.TCEL_01721	1.646e-128	429.0	COG1866@1|root,COG1866@2|Bacteria,1TPQV@1239|Firmicutes,248JE@186801|Clostridia,36DFD@31979|Clostridiaceae	186801|Clostridia	H	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA	pckA	-	4.1.1.49	ko:K01610	ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200	M00003,M00170	R00341	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPCK_ATP
HKD2_k127_5081738_7	589865.DaAHT2_2327	9.294e-07	58.0	COG0461@1|root,COG0461@2|Bacteria,1R13T@1224|Proteobacteria,43D60@68525|delta/epsilon subdivisions,2X8CT@28221|Deltaproteobacteria,2MPN8@213118|Desulfobacterales	28221|Deltaproteobacteria	F	PilZ domain	-	-	-	-	-	-	-	-	-	-	-	-	PilZ
HKD2_k127_5081738_2	1167006.UWK_00776	2.84e-92	305.0	COG3448@1|root,COG3448@2|Bacteria,1MXJG@1224|Proteobacteria,42RSQ@68525|delta/epsilon subdivisions,2WNED@28221|Deltaproteobacteria,2MJRX@213118|Desulfobacterales	28221|Deltaproteobacteria	T	PFAM HPP family	-	-	-	ko:K07168	-	-	-	-	ko00000	-	-	-	HPP
HKD2_k127_5081738_4	1167006.UWK_00777	1.484e-58	210.0	COG3448@1|root,COG3448@2|Bacteria,1Q1A8@1224|Proteobacteria,42SIQ@68525|delta/epsilon subdivisions,2WPF0@28221|Deltaproteobacteria,2MKBJ@213118|Desulfobacterales	28221|Deltaproteobacteria	T	PFAM CBS domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS
HKD2_k127_5081738_6	1121403.AUCV01000078_gene4202	2.064e-14	73.0	COG1141@1|root,COG1141@2|Bacteria,1NFMM@1224|Proteobacteria,42WKK@68525|delta/epsilon subdivisions,2WRFD@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Divergent 4Fe-4S mono-cluster	-	-	-	ko:K05337	-	-	-	-	ko00000	-	-	-	Fer4_13
HKD2_k127_508764_3	1121403.AUCV01000001_gene959	7.162e-38	158.0	COG3307@1|root,COG3307@2|Bacteria,1N25I@1224|Proteobacteria,42RSJ@68525|delta/epsilon subdivisions	1224|Proteobacteria	M	O-Antigen ligase	-	-	-	ko:K02847	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01005,ko02000	9.B.67.4,9.B.67.5	-	-	Wzy_C
HKD2_k127_508764_1	1121403.AUCV01000001_gene784	7.654e-135	440.0	COG0438@1|root,COG0438@2|Bacteria,1MU9C@1224|Proteobacteria,42Q7R@68525|delta/epsilon subdivisions,2WQJC@28221|Deltaproteobacteria,2MMM6@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
HKD2_k127_508764_0	1121403.AUCV01000001_gene958	9.981e-249	781.0	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,42M01@68525|delta/epsilon subdivisions,2WJ7M@28221|Deltaproteobacteria,2MHMW@213118|Desulfobacterales	28221|Deltaproteobacteria	V	Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation	msbA	-	-	ko:K06147,ko:K11085	ko02010,map02010	-	-	-	ko00000,ko00001,ko01000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
HKD2_k127_508764_6	941449.dsx2_2362	6.127e-06	58.0	COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,42MFH@68525|delta/epsilon subdivisions,2WIRW@28221|Deltaproteobacteria,2M7VS@213115|Desulfovibrionales	28221|Deltaproteobacteria	KT	PFAM sigma-54 factor interaction domain-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,PAS_4,PAS_9,Sigma54_activat
HKD2_k127_508764_4	335543.Sfum_3320	4.303e-25	115.0	2FHP5@1|root,349GT@2|Bacteria,1P2PF@1224|Proteobacteria,431EE@68525|delta/epsilon subdivisions,2WWX5@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_508764_2	525897.Dbac_1695	1.913e-62	231.0	COG1596@1|root,COG1596@2|Bacteria,1N7GP@1224|Proteobacteria,42MNP@68525|delta/epsilon subdivisions,2WMJZ@28221|Deltaproteobacteria,2MG5N@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	Polysaccharide biosynthesis/export protein	wza2	-	-	ko:K01991	ko02026,map02026	-	-	-	ko00000,ko00001,ko02000	1.B.18	-	-	Poly_export,SLBB
HKD2_k127_508764_5	525897.Dbac_1691	8.879e-16	88.0	COG3307@1|root,COG3307@2|Bacteria,1N225@1224|Proteobacteria,42QDQ@68525|delta/epsilon subdivisions,2WM6B@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	PFAM O-Antigen	-	-	-	ko:K18814	-	-	-	-	ko00000,ko02000	9.B.67.1	-	-	TPR_14,TPR_16,TPR_8,Wzy_C
HKD2_k127_5095766_4	1167006.UWK_00891	3.24e-96	320.0	COG0745@1|root,COG0745@2|Bacteria,1MY2Z@1224|Proteobacteria,42MP1@68525|delta/epsilon subdivisions,2WJPD@28221|Deltaproteobacteria,2MJ7C@213118|Desulfobacterales	28221|Deltaproteobacteria	T	PFAM response regulator receiver	-	-	-	ko:K07657	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
HKD2_k127_5095766_0	1121403.AUCV01000001_gene697	2.31e-160	524.0	COG5002@1|root,COG5002@2|Bacteria,1MWF3@1224|Proteobacteria,42NB5@68525|delta/epsilon subdivisions,2WJGX@28221|Deltaproteobacteria,2MI1J@213118|Desulfobacterales	28221|Deltaproteobacteria	T	histidine kinase HAMP region domain protein	phoR	-	2.7.13.3	ko:K07636	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_8,sCache_like
HKD2_k127_5095766_2	1265505.ATUG01000001_gene4811	5.415e-99	344.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,43E1J@68525|delta/epsilon subdivisions,2X76W@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Signal Transduction Histidine Kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
HKD2_k127_5095766_1	1499967.BAYZ01000177_gene5743	2.792e-112	377.0	COG2204@1|root,COG2204@2|Bacteria,2NQHI@2323|unclassified Bacteria	2|Bacteria	T	Sigma-54 interaction domain	-	-	-	ko:K07713	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD2_k127_5095766_3	679926.Mpet_1463	7.739e-99	351.0	COG1555@1|root,arCOG09405@2157|Archaea,2XXCV@28890|Euryarchaeota	28890|Euryarchaeota	L	PFAM Peptidoglycan-binding domain 1 protein	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_1
HKD2_k127_5096980_2	589865.DaAHT2_0752	6.109e-33	133.0	28WYN@1|root,2ZIXP@2|Bacteria,1NRMH@1224|Proteobacteria,42YM3@68525|delta/epsilon subdivisions	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Paired_CXXCH_1
HKD2_k127_5096980_0	589865.DaAHT2_0393	6.057e-82	291.0	COG3391@1|root,COG3391@2|Bacteria,1PZUI@1224|Proteobacteria,43EHS@68525|delta/epsilon subdivisions,2X9G8@28221|Deltaproteobacteria,2MPBM@213118|Desulfobacterales	2|Bacteria	S	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_D1,Lactonase
HKD2_k127_5096980_1	96561.Dole_2419	1.729e-65	246.0	COG0457@1|root,COG0457@2|Bacteria,1NFQW@1224|Proteobacteria,42MT2@68525|delta/epsilon subdivisions,2WKWA@28221|Deltaproteobacteria,2MJFK@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Tetratricopeptide TPR_2 repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_11,TPR_16,TPR_2,TPR_4,TPR_8
HKD2_k127_5096980_3	221359.RS9916_39376	4.855e-17	86.0	COG0457@1|root,COG0859@1|root,COG0457@2|Bacteria,COG0859@2|Bacteria,1G193@1117|Cyanobacteria,1H438@1129|Synechococcus	1117|Cyanobacteria	M	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_11,TPR_2,TPR_8
HKD2_k127_5110009_4	1121403.AUCV01000008_gene1586	8.574e-59	209.0	COG1825@1|root,COG1825@2|Bacteria,1NC57@1224|Proteobacteria,42TM3@68525|delta/epsilon subdivisions,2X6X4@28221|Deltaproteobacteria,2MPIS@213118|Desulfobacterales	28221|Deltaproteobacteria	J	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance	ctc	-	-	ko:K02897	ko03010,map03010	M00178	-	-	ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L25p,Ribosomal_TL5_C
HKD2_k127_5110009_3	1121403.AUCV01000008_gene1585	1.819e-160	511.0	COG0462@1|root,COG0462@2|Bacteria,1MW21@1224|Proteobacteria,42MI2@68525|delta/epsilon subdivisions,2WJ5W@28221|Deltaproteobacteria,2MIJR@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	prs	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2848	Pribosyl_synth,Pribosyltran_N
HKD2_k127_5110009_7	1151292.QEW_4200	9.485e-12	69.0	COG1947@1|root,COG1947@2|Bacteria,1TPXV@1239|Firmicutes,24898@186801|Clostridia,25QT8@186804|Peptostreptococcaceae	186801|Clostridia	F	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol	ispE	-	2.7.1.148	ko:K00919	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05634	RC00002,RC01439	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
HKD2_k127_5110009_5	589865.DaAHT2_0599	1.761e-53	195.0	COG1947@1|root,COG1947@2|Bacteria,1MVU3@1224|Proteobacteria,42RGS@68525|delta/epsilon subdivisions,2WNJR@28221|Deltaproteobacteria,2MJU3@213118|Desulfobacterales	28221|Deltaproteobacteria	I	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol	ispE	GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0044237,GO:0050515	2.7.1.148	ko:K00919	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05634	RC00002,RC01439	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
HKD2_k127_5110009_6	1167006.UWK_02493	1.373e-34	135.0	2EAFJ@1|root,334IY@2|Bacteria,1NA2Y@1224|Proteobacteria,42VJ1@68525|delta/epsilon subdivisions,2WRKE@28221|Deltaproteobacteria,2MKY4@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF1844)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1844
HKD2_k127_5110009_1	1167006.UWK_02492	4.07e-263	818.0	COG0111@1|root,COG0111@2|Bacteria,1MU5Z@1224|Proteobacteria,42M1C@68525|delta/epsilon subdivisions,2WIZQ@28221|Deltaproteobacteria,2MHQ6@213118|Desulfobacterales	28221|Deltaproteobacteria	E	D-isomer specific 2-hydroxyacid dehydrogenase catalytic	-	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C,ACT
HKD2_k127_5110009_2	1121403.AUCV01000008_gene1582	9.376e-242	754.0	COG0008@1|root,COG0008@2|Bacteria,1MUCR@1224|Proteobacteria,42MAI@68525|delta/epsilon subdivisions,2WJ8M@28221|Deltaproteobacteria,2MHXE@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
HKD2_k127_5110009_0	1121403.AUCV01000008_gene1581	1.053e-299	925.0	COG0008@1|root,COG0008@2|Bacteria,1MUC8@1224|Proteobacteria,42MAX@68525|delta/epsilon subdivisions,2WJ5B@28221|Deltaproteobacteria,2MHVD@213118|Desulfobacterales	28221|Deltaproteobacteria	J	TIGRFAM glutaminyl-tRNA synthetase	glnS	-	6.1.1.18	ko:K01886	ko00970,ko01100,map00970,map01100	M00359,M00360	R03652	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	GatB_Yqey,tRNA-synt_1c,tRNA-synt_1c_C
HKD2_k127_5113763_0	1123371.ATXH01000001_gene1284	1.863e-210	670.0	COG3005@1|root,COG3005@2|Bacteria,2GHZU@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	C	Doubled CXXCH motif (Paired_CXXCH_1)	-	-	-	-	-	-	-	-	-	-	-	-	Paired_CXXCH_1
HKD2_k127_5146567_13	1167006.UWK_00768	7.636e-74	253.0	COG1309@1|root,COG1309@2|Bacteria,1NPSF@1224|Proteobacteria,42T2M@68525|delta/epsilon subdivisions,2WPN6@28221|Deltaproteobacteria,2MKSN@213118|Desulfobacterales	28221|Deltaproteobacteria	K	PFAM YsiA-like protein, C-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_4,TetR_N
HKD2_k127_5146567_9	1121403.AUCV01000020_gene3149	4.498e-91	312.0	COG0565@1|root,COG0565@2|Bacteria,1N47Y@1224|Proteobacteria,42R3K@68525|delta/epsilon subdivisions,2WJNA@28221|Deltaproteobacteria,2MJFV@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA	trmJ	-	2.1.1.200	ko:K02533,ko:K15396	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	SpoU_methylase
HKD2_k127_5146567_15	1121403.AUCV01000020_gene3148	9.314e-60	211.0	2CBBS@1|root,33312@2|Bacteria,1P92W@1224|Proteobacteria,43328@68525|delta/epsilon subdivisions	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5146567_12	338963.Pcar_3024	1.212e-74	260.0	COG1108@1|root,COG1108@2|Bacteria,1MVC2@1224|Proteobacteria,42MYM@68525|delta/epsilon subdivisions,2WJAM@28221|Deltaproteobacteria,43UC9@69541|Desulfuromonadales	28221|Deltaproteobacteria	P	ABC 3 transport family	-	-	-	ko:K09816,ko:K09819	ko02010,map02010	M00242,M00243	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15,3.A.1.15.3,3.A.1.15.5	-	-	ABC-3
HKD2_k127_5146567_11	933262.AXAM01000001_gene416	4.511e-83	283.0	COG1121@1|root,COG1121@2|Bacteria,1MUDW@1224|Proteobacteria,42NI8@68525|delta/epsilon subdivisions,2WKMZ@28221|Deltaproteobacteria,2MHMM@213118|Desulfobacterales	28221|Deltaproteobacteria	P	PFAM ABC transporter	-	-	-	ko:K09817	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	ABC_tran
HKD2_k127_5146567_3	1121403.AUCV01000020_gene3147	1.519e-228	730.0	COG0557@1|root,COG0557@2|Bacteria,1MUS6@1224|Proteobacteria,42NGS@68525|delta/epsilon subdivisions,2WIWF@28221|Deltaproteobacteria,2MPF7@213118|Desulfobacterales	28221|Deltaproteobacteria	J	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs	rnr	-	-	ko:K12573	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	OB_RNB,RNB,S1
HKD2_k127_5146567_1	1121403.AUCV01000020_gene3146	8.35e-322	997.0	COG0317@1|root,COG0317@2|Bacteria,1NTNN@1224|Proteobacteria,42YMH@68525|delta/epsilon subdivisions,2WTI7@28221|Deltaproteobacteria,2MPWI@213118|Desulfobacterales	28221|Deltaproteobacteria	KT	Region found in RelA / SpoT proteins	-	-	2.7.6.5	ko:K00951	ko00230,map00230	-	R00429	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	HD_4,RelA_SpoT,TGS
HKD2_k127_5146567_18	1121403.AUCV01000024_gene3437	7.518e-21	97.0	COG1826@1|root,COG1826@2|Bacteria,1NI3F@1224|Proteobacteria,42VIZ@68525|delta/epsilon subdivisions,2WRC5@28221|Deltaproteobacteria,2MM5W@213118|Desulfobacterales	28221|Deltaproteobacteria	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system	tatB	-	-	ko:K03116,ko:K03117	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
HKD2_k127_5146567_8	1121403.AUCV01000024_gene3438	4.094e-94	315.0	COG0805@1|root,COG0805@2|Bacteria,1MVAY@1224|Proteobacteria,42MM7@68525|delta/epsilon subdivisions,2WKJW@28221|Deltaproteobacteria,2MI7G@213118|Desulfobacterales	28221|Deltaproteobacteria	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides	tatC	-	-	ko:K03118	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	TatC
HKD2_k127_5146567_17	1205753.A989_06783	4.059e-44	165.0	COG2839@1|root,COG2839@2|Bacteria,1MZEV@1224|Proteobacteria,1SAFY@1236|Gammaproteobacteria,1X6YB@135614|Xanthomonadales	135614|Xanthomonadales	S	protein conserved in bacteria	-	-	-	ko:K09793	-	-	-	-	ko00000	-	-	-	DUF456
HKD2_k127_5146567_4	1387312.BAUS01000002_gene827	5.449e-167	533.0	COG0475@1|root,COG0475@2|Bacteria,1MVGV@1224|Proteobacteria,2VJ0E@28216|Betaproteobacteria	28216|Betaproteobacteria	P	Sodium hydrogen exchanger	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
HKD2_k127_5146567_0	1167006.UWK_03045	0.0	1041.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,42M8F@68525|delta/epsilon subdivisions,2WIU0@28221|Deltaproteobacteria,2MIS4@213118|Desulfobacterales	28221|Deltaproteobacteria	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	ctpF	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
HKD2_k127_5146567_5	1121403.AUCV01000024_gene3441	1.791e-158	505.0	COG0535@1|root,COG0535@2|Bacteria,1R4SH@1224|Proteobacteria,42NZR@68525|delta/epsilon subdivisions,2WKQA@28221|Deltaproteobacteria,2MHSP@213118|Desulfobacterales	28221|Deltaproteobacteria	S	PFAM Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM
HKD2_k127_5146567_14	1121403.AUCV01000024_gene3442	2.065e-60	215.0	COG0590@1|root,COG0590@2|Bacteria,1RIK5@1224|Proteobacteria,42T2I@68525|delta/epsilon subdivisions,2WPRC@28221|Deltaproteobacteria,2MJWC@213118|Desulfobacterales	28221|Deltaproteobacteria	FJ	PFAM CMP dCMP deaminase zinc-binding	-	-	3.5.4.33	ko:K11991	-	-	R10223	RC00477	ko00000,ko01000,ko03016	-	-	-	dCMP_cyt_deam_1
HKD2_k127_5146567_7	880073.Calab_1764	2.733e-123	419.0	COG4191@1|root,COG4191@2|Bacteria,2NP93@2323|unclassified Bacteria	2|Bacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
HKD2_k127_5146567_16	1167006.UWK_02286	4.863e-55	197.0	COG2331@1|root,COG2331@2|Bacteria,1R35D@1224|Proteobacteria,43DJ8@68525|delta/epsilon subdivisions,2X8QH@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Regulatory protein, FmdB family	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5146567_6	589865.DaAHT2_0294	1.848e-142	465.0	COG0337@1|root,COG0337@2|Bacteria,1MUBK@1224|Proteobacteria,42MW5@68525|delta/epsilon subdivisions,2WJKR@28221|Deltaproteobacteria,2MIGY@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)	aroB	-	2.7.1.71,4.2.3.4	ko:K01735,ko:K13829	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412,R03083	RC00002,RC00078,RC00847	ko00000,ko00001,ko00002,ko01000	-	-	-	DHQ_synthase,SKI
HKD2_k127_5146567_2	1121403.AUCV01000024_gene3449	1.574e-239	745.0	COG2046@1|root,COG2046@2|Bacteria,1MUQB@1224|Proteobacteria,42NAI@68525|delta/epsilon subdivisions,2WJYY@28221|Deltaproteobacteria,2MIP2@213118|Desulfobacterales	28221|Deltaproteobacteria	P	sulfate adenylyltransferase	sat	-	2.7.1.25,2.7.7.4	ko:K00958,ko:K13811	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00509,R00529,R04928,R04929	RC00002,RC00078,RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	APS_kinase,ATP-sulfurylase,PUA_2
HKD2_k127_5146567_10	1167006.UWK_02283	3.629e-85	286.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,42M2R@68525|delta/epsilon subdivisions,2WJ4J@28221|Deltaproteobacteria,2MHN2@213118|Desulfobacterales	28221|Deltaproteobacteria	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	copA	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
HKD2_k127_5167802_0	765420.OSCT_3068	4.013e-81	281.0	COG2339@1|root,COG2339@2|Bacteria,2G946@200795|Chloroflexi,375Y0@32061|Chloroflexia	32061|Chloroflexia	S	Protease prsW family	-	-	-	-	-	-	-	-	-	-	-	-	PrsW-protease
HKD2_k127_5167802_1	926569.ANT_22530	1.549e-21	101.0	COG5011@1|root,COG5011@2|Bacteria,2G71I@200795|Chloroflexi	200795|Chloroflexi	S	Uncharacterized protein conserved in bacteria (DUF2344)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2344
HKD2_k127_5170890_1	589865.DaAHT2_1164	1.526e-61	217.0	COG0125@1|root,COG0125@2|Bacteria,1MV9C@1224|Proteobacteria,42RK3@68525|delta/epsilon subdivisions,2WNES@28221|Deltaproteobacteria,2MJNS@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis	tmk	GO:0003674,GO:0003824,GO:0004798,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009165,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylate_kin
HKD2_k127_5170890_0	1121403.AUCV01000008_gene1648	3.227e-117	400.0	COG0457@1|root,COG0457@2|Bacteria,1MYB8@1224|Proteobacteria,42P5H@68525|delta/epsilon subdivisions,2WKAU@28221|Deltaproteobacteria,2MIEU@213118|Desulfobacterales	28221|Deltaproteobacteria	G	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_14,TPR_16,TPR_19,TPR_2,TPR_4,TPR_6,TPR_7,TPR_8
HKD2_k127_5223769_2	1121403.AUCV01000005_gene336	6.594e-32	126.0	COG0789@1|root,COG0789@2|Bacteria,1N9MT@1224|Proteobacteria	1224|Proteobacteria	K	MerR HTH family regulatory protein	cbpM	-	-	ko:K18997	-	-	-	-	ko00000,ko03036	-	-	-	MerR_2
HKD2_k127_5223769_0	1121403.AUCV01000005_gene337	8.794e-139	447.0	COG0484@1|root,COG0484@2|Bacteria,1MUZ4@1224|Proteobacteria,42NBY@68525|delta/epsilon subdivisions,2WJV2@28221|Deltaproteobacteria,2MMS5@213118|Desulfobacterales	28221|Deltaproteobacteria	O	DnaJ molecular chaperone homology domain	cbpA	-	-	ko:K05516	-	-	-	-	ko00000,ko03036,ko03110	-	-	-	DnaJ,DnaJ_C
HKD2_k127_5223769_1	1167006.UWK_01684	1.914e-37	149.0	COG0703@1|root,COG0703@2|Bacteria,1MUFJ@1224|Proteobacteria,42TW3@68525|delta/epsilon subdivisions,2WPZS@28221|Deltaproteobacteria,2MKHQ@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate	aroK	-	2.7.1.71	ko:K00891	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	SKI
HKD2_k127_5259847_4	1121403.AUCV01000021_gene3602	3.085e-28	121.0	COG0144@1|root,COG0781@1|root,COG0144@2|Bacteria,COG0781@2|Bacteria,1MWPE@1224|Proteobacteria,42P2T@68525|delta/epsilon subdivisions,2WJ9B@28221|Deltaproteobacteria,2MI5Y@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA	rsmB	-	2.1.1.176	ko:K03500	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltr_RsmB-F,Methyltr_RsmF_N,NusB
HKD2_k127_5259847_2	1121403.AUCV01000002_gene480	5.795e-158	526.0	COG0729@1|root,COG0729@2|Bacteria,1MUKM@1224|Proteobacteria,42MB2@68525|delta/epsilon subdivisions,2WJAF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	PFAM surface antigen (D15)	-	-	-	ko:K07277,ko:K07278	-	-	-	-	ko00000,ko02000,ko03029	1.B.33,1.B.33.2.4	-	-	Bac_surface_Ag,POTRA,POTRA_TamA_1
HKD2_k127_5259847_3	472759.Nhal_0217	1.087e-118	424.0	COG2911@1|root,COG2911@2|Bacteria,1MUVD@1224|Proteobacteria,1RMMF@1236|Gammaproteobacteria,1WWU1@135613|Chromatiales	135613|Chromatiales	S	TamB, inner membrane protein subunit of TAM complex	-	-	-	ko:K09800	-	-	-	-	ko00000,ko02000	-	-	-	TamB
HKD2_k127_5259847_1	1121403.AUCV01000016_gene4398	6.677e-229	729.0	COG0586@1|root,COG0671@1|root,COG0586@2|Bacteria,COG0671@2|Bacteria,1R0F3@1224|Proteobacteria,42SXG@68525|delta/epsilon subdivisions,2WP6Y@28221|Deltaproteobacteria,2MNMK@213118|Desulfobacterales	28221|Deltaproteobacteria	I	LssY C-terminus	-	-	-	-	-	-	-	-	-	-	-	-	LssY_C,PAP2,SNARE_assoc
HKD2_k127_5259847_0	589865.DaAHT2_0173	0.0	1112.0	COG3968@1|root,COG3968@2|Bacteria,1QUKF@1224|Proteobacteria,42PBH@68525|delta/epsilon subdivisions,2WJZG@28221|Deltaproteobacteria,2MMWW@213118|Desulfobacterales	28221|Deltaproteobacteria	S	PFAM glutamine synthetase catalytic region	glnN	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	GSIII_N,Gln-synt_C
HKD2_k127_5259847_5	1121403.AUCV01000034_gene3838	1.166e-22	100.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
HKD2_k127_5301958_2	1121403.AUCV01000020_gene3114	8.187e-107	365.0	COG3635@1|root,COG3635@2|Bacteria,1R4TM@1224|Proteobacteria,43DQP@68525|delta/epsilon subdivisions,2X6VW@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	2,3-bisphosphoglycerate-independent phosphoglycerate mutase	-	-	5.4.2.12	ko:K15635	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,PhosphMutase
HKD2_k127_5301958_0	1121403.AUCV01000020_gene3115	8.705e-197	623.0	COG0460@1|root,COG0460@2|Bacteria,1MUDC@1224|Proteobacteria,42MGS@68525|delta/epsilon subdivisions,2WJ1K@28221|Deltaproteobacteria,2MINV@213118|Desulfobacterales	28221|Deltaproteobacteria	E	PFAM homoserine dehydrogenase	hom	-	1.1.1.3	ko:K00003	ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00017,M00018	R01773,R01775	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,Homoserine_dh,NAD_binding_3
HKD2_k127_5301958_1	1121403.AUCV01000020_gene3116	2.887e-121	391.0	COG0563@1|root,COG0563@2|Bacteria,1MXCZ@1224|Proteobacteria,42M8E@68525|delta/epsilon subdivisions,2WJH0@28221|Deltaproteobacteria,2MIFR@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism	adk	-	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ADK,ATP_bind_3
HKD2_k127_5326056_3	1121403.AUCV01000020_gene3076	5.007e-10	70.0	2DRH1@1|root,33BQ8@2|Bacteria,1NM8D@1224|Proteobacteria,42XND@68525|delta/epsilon subdivisions,2WSKN@28221|Deltaproteobacteria,2MM85@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	gspN	-	-	-	-	-	-	-	-	-	-	-	AsmA_2
HKD2_k127_5326056_2	1121405.dsmv_0461	5.154e-28	125.0	COG3149@1|root,COG3149@2|Bacteria,1NEZ3@1224|Proteobacteria,42WMP@68525|delta/epsilon subdivisions,2WR67@28221|Deltaproteobacteria,2MKKX@213118|Desulfobacterales	28221|Deltaproteobacteria	U	Type II secretion system (T2SS), protein M	-	-	-	ko:K02462	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSM
HKD2_k127_5326056_0	1121403.AUCV01000020_gene3078	6.29e-77	276.0	COG3166@1|root,COG4972@1|root,COG3166@2|Bacteria,COG4972@2|Bacteria,1MYIB@1224|Proteobacteria,42SIX@68525|delta/epsilon subdivisions,2WP1G@28221|Deltaproteobacteria,2MKAU@213118|Desulfobacterales	28221|Deltaproteobacteria	NU	Fimbrial assembly family protein	gspL	-	-	ko:K02461	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	GspL_C,PilM_2,PilN,T2SSL
HKD2_k127_5326056_1	1121403.AUCV01000020_gene3079	1.392e-68	244.0	COG3156@1|root,COG3156@2|Bacteria,1PZ6I@1224|Proteobacteria,42Q46@68525|delta/epsilon subdivisions,2WM8B@28221|Deltaproteobacteria,2MI8C@213118|Desulfobacterales	28221|Deltaproteobacteria	U	General secretion pathway protein K	-	-	-	ko:K02460	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSK
HKD2_k127_5382257_0	290397.Adeh_1565	2.226e-110	379.0	COG0370@1|root,COG0370@2|Bacteria,1MUZC@1224|Proteobacteria,42MCY@68525|delta/epsilon subdivisions,2WIWJ@28221|Deltaproteobacteria,2YYYV@29|Myxococcales	28221|Deltaproteobacteria	P	transporter of a GTP-driven Fe(2 ) uptake system	-	-	-	ko:K04759	-	-	-	-	ko00000,ko02000	9.A.8.1	-	-	FeoB_C,FeoB_N,Gate
HKD2_k127_5382257_1	247490.KSU1_C1550	1.135e-46	175.0	COG1321@1|root,COG1918@1|root,COG1321@2|Bacteria,COG1918@2|Bacteria	2|Bacteria	P	iron ion homeostasis	ideR	-	-	ko:K03709,ko:K04758	-	-	-	-	ko00000,ko02000,ko03000	-	-	-	Fe_dep_repr_C,FeoA
HKD2_k127_5389485_0	1121403.AUCV01000020_gene3152	4.219e-174	550.0	COG0542@1|root,COG0542@2|Bacteria,1MURH@1224|Proteobacteria,42M9S@68525|delta/epsilon subdivisions,2WJSZ@28221|Deltaproteobacteria,2MHW3@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpB	-	-	ko:K03695	ko04213,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
HKD2_k127_5389485_3	1121403.AUCV01000020_gene3153	5.651e-36	138.0	2CDMX@1|root,32S1K@2|Bacteria,1N1I8@1224|Proteobacteria,42U31@68525|delta/epsilon subdivisions,2WQJE@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5389485_2	631362.Thi970DRAFT_00801	1.057e-97	346.0	COG1287@1|root,COG1287@2|Bacteria,1QR7W@1224|Proteobacteria,1SN01@1236|Gammaproteobacteria,1X072@135613|Chromatiales	135613|Chromatiales	S	Oligosaccharyl transferase STT3 subunit	-	-	2.4.99.18	ko:K07151	ko00510,ko00513,ko01100,ko04141,map00510,map00513,map01100,map04141	M00072	R04216,R05976	RC00005,RC00482	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT66	-	STT3
HKD2_k127_5389485_1	1121439.dsat_2433	2.203e-116	383.0	COG0730@1|root,COG0730@2|Bacteria,1PYDH@1224|Proteobacteria,42P28@68525|delta/epsilon subdivisions,2WK6D@28221|Deltaproteobacteria,2M87J@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
HKD2_k127_5389485_4	1123489.AUAN01000022_gene40	1.052e-06	51.0	2ERMT@1|root,33J79@2|Bacteria,1VKZE@1239|Firmicutes	1239|Firmicutes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5390361_0	1121403.AUCV01000002_gene525	4.298e-94	319.0	COG0324@1|root,COG0324@2|Bacteria,1MUB2@1224|Proteobacteria,42M7V@68525|delta/epsilon subdivisions,2WIUB@28221|Deltaproteobacteria,2MIV4@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)	miaA	GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016765,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0052381,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.5.1.75	ko:K00791	ko00908,ko01100,ko01110,map00908,map01100,map01110	-	R01122	RC02820	ko00000,ko00001,ko01000,ko01006,ko03016	-	-	-	IPPT
HKD2_k127_5390361_1	1089548.KI783301_gene1504	4.898e-09	63.0	COG1555@1|root,COG1555@2|Bacteria,1VA3W@1239|Firmicutes,4HKJ1@91061|Bacilli,3WEMS@539002|Bacillales incertae sedis	91061|Bacilli	L	SLBB domain	comEA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K02237	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	HHH_3,SLBB
HKD2_k127_5397962_4	879212.DespoDRAFT_01336	5.085e-14	72.0	COG1917@1|root,COG1917@2|Bacteria,1RJPB@1224|Proteobacteria,42T5Q@68525|delta/epsilon subdivisions,2WPWB@28221|Deltaproteobacteria,2MNKI@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5397962_0	1322246.BN4_12307	1.309e-152	492.0	COG2203@1|root,COG3437@1|root,COG2203@2|Bacteria,COG3437@2|Bacteria,1RGKE@1224|Proteobacteria,42QI9@68525|delta/epsilon subdivisions,2WIV3@28221|Deltaproteobacteria,2M9A9@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	metal-dependent phosphohydrolase HD region	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HD,Lactamase_B_2
HKD2_k127_5397962_3	331678.Cphamn1_0106	3.002e-27	118.0	COG0724@1|root,COG0724@2|Bacteria,1FE64@1090|Chlorobi	1090|Chlorobi	S	PFAM RNP-1 like RNA-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	RRM_1
HKD2_k127_5397962_1	1167006.UWK_00944	7.545e-105	348.0	COG0583@1|root,COG0583@2|Bacteria,1MWVU@1224|Proteobacteria,42PMQ@68525|delta/epsilon subdivisions,2WKB8@28221|Deltaproteobacteria,2MIF9@213118|Desulfobacterales	28221|Deltaproteobacteria	K	Transcriptional regulator, LysR	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HKD2_k127_5397962_2	338966.Ppro_2150	4.767e-56	202.0	COG0507@1|root,COG0507@2|Bacteria,1MW43@1224|Proteobacteria,42NRK@68525|delta/epsilon subdivisions,2WIM6@28221|Deltaproteobacteria,43TAV@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD	recD	-	3.1.11.5	ko:K03581	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AAA_30,UvrD_C_2
HKD2_k127_5436287_0	1121403.AUCV01000027_gene2526	2.002e-283	882.0	COG0529@1|root,COG2046@1|root,COG0529@2|Bacteria,COG2046@2|Bacteria,1MUQB@1224|Proteobacteria,43BR1@68525|delta/epsilon subdivisions,2WIIS@28221|Deltaproteobacteria,2MIQ9@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Catalyzes the synthesis of activated sulfate	cysC	-	2.7.7.4	ko:K00958	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00529,R04929	RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	APS_kinase,ATP-sulfurylase,PUA_2
HKD2_k127_5436287_5	338963.Pcar_3033	1.226e-45	171.0	2CA8B@1|root,33XH7@2|Bacteria,1NVUZ@1224|Proteobacteria,4300U@68525|delta/epsilon subdivisions,2WV6E@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5436287_8	335543.Sfum_0336	2.071e-07	58.0	COG0461@1|root,COG0461@2|Bacteria	2|Bacteria	F	orotate phosphoribosyltransferase activity	pyrE	-	2.4.2.10	ko:K00762	ko00240,ko01100,map00240,map01100	M00051	R01870	RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	PilZ,Pribosyltran
HKD2_k127_5436287_7	215803.DB30_5463	1.685e-11	72.0	COG0457@1|root,COG0664@1|root,COG0457@2|Bacteria,COG0664@2|Bacteria,1N1ZG@1224|Proteobacteria,4336W@68525|delta/epsilon subdivisions,2WYCK@28221|Deltaproteobacteria,2YXD4@29|Myxococcales	28221|Deltaproteobacteria	T	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
HKD2_k127_5436287_6	1408823.AXUS01000073_gene990	1.141e-14	75.0	2DR59@1|root,33A7S@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5436287_1	883.DvMF_0112	3.204e-280	882.0	COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,42M9W@68525|delta/epsilon subdivisions,2WJ29@28221|Deltaproteobacteria,2M8M4@213115|Desulfovibrionales	28221|Deltaproteobacteria	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon-2	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
HKD2_k127_5436287_2	1121403.AUCV01000013_gene3949	2.359e-219	686.0	COG1219@1|root,COG1219@2|Bacteria,1MVQK@1224|Proteobacteria,42MWJ@68525|delta/epsilon subdivisions,2WJ8Q@28221|Deltaproteobacteria,2MHKY@213118|Desulfobacterales	28221|Deltaproteobacteria	O	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP	clpX	GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030163,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044238,GO:0051301,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575	-	ko:K03544	ko04112,map04112	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA_2,ClpB_D2-small,zf-C4_ClpX
HKD2_k127_5436287_4	1121403.AUCV01000013_gene3950	7.341e-104	340.0	COG0740@1|root,COG0740@2|Bacteria,1MV46@1224|Proteobacteria,42MFU@68525|delta/epsilon subdivisions,2WK74@28221|Deltaproteobacteria,2MJ0K@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins	clpP	-	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	CLP_protease
HKD2_k127_5436287_3	1121403.AUCV01000013_gene3951	2.106e-172	551.0	COG0544@1|root,COG0544@2|Bacteria,1MUJP@1224|Proteobacteria,42MBB@68525|delta/epsilon subdivisions,2WIU1@28221|Deltaproteobacteria,2MHZ5@213118|Desulfobacterales	28221|Deltaproteobacteria	D	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase	tig	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03545	-	-	-	-	ko00000	-	-	-	FKBP_C,Trigger_C,Trigger_N
HKD2_k127_5436287_9	1121403.AUCV01000024_gene3428	3.682e-06	48.0	COG0751@1|root,COG0751@2|Bacteria,1MV2F@1224|Proteobacteria,42M6A@68525|delta/epsilon subdivisions,2WJIT@28221|Deltaproteobacteria,2MHVB@213118|Desulfobacterales	28221|Deltaproteobacteria	J	glycyl-tRNA synthetase, beta	glyS	-	6.1.1.14	ko:K01879	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_1,tRNA_synt_2f
HKD2_k127_547232_5	1121403.AUCV01000012_gene4062	3.725e-11	65.0	COG0744@1|root,COG5009@1|root,COG0744@2|Bacteria,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,42MJB@68525|delta/epsilon subdivisions,2WIXF@28221|Deltaproteobacteria,2MI9W@213118|Desulfobacterales	28221|Deltaproteobacteria	M	TIGRFAM penicillin-binding protein, 1A family	mrcA	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	iAF987.Gmet_0354	PCB_OB,Transgly,Transpeptidase
HKD2_k127_547232_0	1121403.AUCV01000012_gene4061	6.281e-170	552.0	COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,1MWKE@1224|Proteobacteria,42M5C@68525|delta/epsilon subdivisions,2WJ54@28221|Deltaproteobacteria,2MJ3U@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Lytic transglycosylase catalytic	mltD2	-	-	ko:K08307	-	-	-	-	ko00000,ko01000,ko01011	-	-	-	LysM,SLT
HKD2_k127_547232_2	1121403.AUCV01000012_gene4060	2.897e-156	503.0	COG1916@1|root,COG1916@2|Bacteria,1MWJ0@1224|Proteobacteria,42P2H@68525|delta/epsilon subdivisions,2WJQM@28221|Deltaproteobacteria,2MI76@213118|Desulfobacterales	28221|Deltaproteobacteria	S	TIGRFAM TraB family protein	-	-	-	-	-	-	-	-	-	-	-	-	TraB
HKD2_k127_547232_4	1121403.AUCV01000012_gene4059	2.168e-27	114.0	COG1534@1|root,COG1534@2|Bacteria,1Q1JA@1224|Proteobacteria,42W6U@68525|delta/epsilon subdivisions,2WQS8@28221|Deltaproteobacteria,2MKUI@213118|Desulfobacterales	28221|Deltaproteobacteria	J	CRS1_YhbY	-	-	-	ko:K07574	-	-	-	-	ko00000,ko03009	-	-	-	CRS1_YhbY
HKD2_k127_547232_3	1123371.ATXH01000001_gene1285	3.24e-46	181.0	COG1729@1|root,COG1729@2|Bacteria	2|Bacteria	S	protein trimerization	slt	-	-	ko:K07114,ko:K08309	-	-	-	-	ko00000,ko01000,ko01011,ko02000	1.A.13.2.2,1.A.13.2.3	GH23	-	SLT,TPR_16,TPR_6
HKD2_k127_547232_1	1121403.AUCV01000002_gene595	4.231e-163	533.0	COG5000@1|root,COG5000@2|Bacteria,1NU7E@1224|Proteobacteria,42YZ2@68525|delta/epsilon subdivisions,2WTQ1@28221|Deltaproteobacteria,2MPM0@213118|Desulfobacterales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	2.7.13.3	ko:K02668,ko:K07709	ko02020,map02020	M00499,M00501	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_10,PAS_4,PAS_9,sCache_3_2
HKD2_k127_5486243_5	1461693.ATO10_10720	1.289e-05	53.0	COG0425@1|root,COG0425@2|Bacteria,1MZA5@1224|Proteobacteria,2UF3C@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Belongs to the sulfur carrier protein TusA family	tusA	-	-	ko:K04085	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	TusA
HKD2_k127_5486243_4	926550.CLDAP_30490	2.66e-28	121.0	COG2210@1|root,COG2210@2|Bacteria,2G77F@200795|Chloroflexi	200795|Chloroflexi	S	DsrE/DsrF/DrsH-like family	-	-	-	-	-	-	-	-	-	-	-	-	DrsE_2
HKD2_k127_5486243_1	1167006.UWK_02855	2.242e-110	389.0	COG0784@1|root,COG4191@1|root,COG0784@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42N46@68525|delta/epsilon subdivisions,2WJT4@28221|Deltaproteobacteria,2MPMZ@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,PocR,Response_reg
HKD2_k127_5486243_3	589865.DaAHT2_0082	7.865e-69	239.0	296ZZ@1|root,2ZU8H@2|Bacteria,1RED2@1224|Proteobacteria,42RDU@68525|delta/epsilon subdivisions,2WPHV@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5486243_0	754476.Q7A_1032	1.236e-147	483.0	COG0700@1|root,COG2715@1|root,COG0700@2|Bacteria,COG2715@2|Bacteria,1MVZ0@1224|Proteobacteria,1RRBY@1236|Gammaproteobacteria,46226@72273|Thiotrichales	72273|Thiotrichales	S	Nucleoside recognition	-	-	-	-	-	-	-	-	-	-	-	-	Gate
HKD2_k127_5486243_2	1232410.KI421422_gene2074	8.482e-96	340.0	COG0642@1|root,COG0834@1|root,COG0834@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,42RWK@68525|delta/epsilon subdivisions,2WNCS@28221|Deltaproteobacteria,43SHW@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	Domains REC, HisKA, HATPase_c	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HATPase_c,HisKA,PAS_4,PAS_9,Response_reg
HKD2_k127_5506241_0	1121403.AUCV01000032_gene2901	1.717e-126	410.0	COG0501@1|root,COG0501@2|Bacteria,1MUV4@1224|Proteobacteria,42MEE@68525|delta/epsilon subdivisions,2WJYV@28221|Deltaproteobacteria,2MJ0G@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Belongs to the peptidase M48B family	htpX	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
HKD2_k127_5506241_2	195250.CM001776_gene2903	5.47e-29	128.0	COG0729@1|root,COG0729@2|Bacteria,1GDRV@1117|Cyanobacteria	1117|Cyanobacteria	M	surface antigen	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5528011_1	1121403.AUCV01000012_gene4087	1.076e-177	562.0	COG0136@1|root,COG0136@2|Bacteria,1MUHG@1224|Proteobacteria,42MDM@68525|delta/epsilon subdivisions,2WJ5Y@28221|Deltaproteobacteria,2MI40@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate	asd	-	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
HKD2_k127_5528011_3	1121403.AUCV01000012_gene4086	1.203e-143	461.0	COG0462@1|root,COG0462@2|Bacteria	2|Bacteria	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	-	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyl_synth,Pribosyltran,Pribosyltran_N
HKD2_k127_5528011_0	1121403.AUCV01000012_gene4085	4.871e-185	584.0	COG0473@1|root,COG0473@2|Bacteria,1MUH4@1224|Proteobacteria,42M8G@68525|delta/epsilon subdivisions,2WIYB@28221|Deltaproteobacteria,2MIG1@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate	leuB	GO:0003674,GO:0003824,GO:0003862,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
HKD2_k127_5528011_2	338966.Ppro_2089	1.05e-159	529.0	COG0784@1|root,COG2202@1|root,COG4936@1|root,COG5002@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG4936@2|Bacteria,COG5002@2|Bacteria,1NC9X@1224|Proteobacteria,43BSJ@68525|delta/epsilon subdivisions,2X73B@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_9,Response_reg
HKD2_k127_5541322_1	439235.Dalk_0736	7.523e-145	474.0	COG2204@1|root,COG2204@2|Bacteria,1MVWX@1224|Proteobacteria,42MIB@68525|delta/epsilon subdivisions,2WJQK@28221|Deltaproteobacteria,2MHU2@213118|Desulfobacterales	28221|Deltaproteobacteria	T	sigma54 specific, transcriptional regulator, Fis family	-	-	-	ko:K02481	-	-	-	-	ko00000,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD2_k127_5541322_0	1121405.dsmv_1129	6.749e-179	601.0	COG3852@1|root,COG4191@1|root,COG3852@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42M1R@68525|delta/epsilon subdivisions,2X734@28221|Deltaproteobacteria,2MIC0@213118|Desulfobacterales	28221|Deltaproteobacteria	T	histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg
HKD2_k127_5546902_5	1121403.AUCV01000034_gene3849	3.254e-35	148.0	COG1426@1|root,COG1426@2|Bacteria,1NIQS@1224|Proteobacteria	1224|Proteobacteria	S	Protein conserved in bacteria	-	-	-	ko:K15539	-	-	-	-	ko00000	-	-	-	DUF4115,HTH_25
HKD2_k127_5546902_2	1121403.AUCV01000034_gene3848	7.885e-96	324.0	COG0760@1|root,COG0760@2|Bacteria,1MVB3@1224|Proteobacteria,42QXH@68525|delta/epsilon subdivisions,2WMN3@28221|Deltaproteobacteria,2MJIP@213118|Desulfobacterales	28221|Deltaproteobacteria	O	peptidyl-prolyl cis-trans isomerase	surA	-	5.2.1.8	ko:K03771	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_2,Rotamase_3,SurA_N,SurA_N_3
HKD2_k127_5546902_3	1121403.AUCV01000021_gene3560	4.066e-84	289.0	COG1011@1|root,COG1011@2|Bacteria,1NH15@1224|Proteobacteria,43CH0@68525|delta/epsilon subdivisions,2X7S8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	TIGRFAM HAD-superfamily hydrolase, subfamily IA, variant 3	-	-	3.1.3.5	ko:K20881	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
HKD2_k127_5546902_0	1121403.AUCV01000021_gene3559	0.0	1433.0	COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,42N8X@68525|delta/epsilon subdivisions,2WIVR@28221|Deltaproteobacteria,2MI3P@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
HKD2_k127_5546902_1	1121403.AUCV01000021_gene3558	0.0	1091.0	COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,42MMA@68525|delta/epsilon subdivisions,2WIZB@28221|Deltaproteobacteria,2MIBK@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamA	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
HKD2_k127_5546902_4	1121403.AUCV01000021_gene3557	2.787e-75	259.0	COG0204@1|root,COG0204@2|Bacteria,1MY51@1224|Proteobacteria,42S1J@68525|delta/epsilon subdivisions,2WP2S@28221|Deltaproteobacteria,2MJG9@213118|Desulfobacterales	28221|Deltaproteobacteria	I	Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family	plsC	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
HKD2_k127_5565908_2	589865.DaAHT2_1929	1.656e-18	90.0	COG0377@1|root,COG0377@2|Bacteria,1MUI2@1224|Proteobacteria,42MDJ@68525|delta/epsilon subdivisions,2WNNV@28221|Deltaproteobacteria,2MNCS@213118|Desulfobacterales	28221|Deltaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoB	-	1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q6
HKD2_k127_5565908_1	1121403.AUCV01000012_gene4032	1.464e-60	212.0	COG0838@1|root,COG0838@2|Bacteria,1PPP3@1224|Proteobacteria,42VF4@68525|delta/epsilon subdivisions,2WRIV@28221|Deltaproteobacteria,2MMCP@213118|Desulfobacterales	28221|Deltaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain	nuoA	-	1.6.5.3	ko:K00330	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q4
HKD2_k127_5565908_0	1121403.AUCV01000012_gene4030	1.014e-191	605.0	COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,42MKR@68525|delta/epsilon subdivisions,2WIS3@28221|Deltaproteobacteria,2MJK2@213118|Desulfobacterales	28221|Deltaproteobacteria	E	PFAM aminotransferase class I and II	aspB	-	2.6.1.1	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
HKD2_k127_5589917_0	1121403.AUCV01000012_gene4068	0.0	1177.0	COG0550@1|root,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,42NQG@68525|delta/epsilon subdivisions,2WJXC@28221|Deltaproteobacteria,2MJBJ@213118|Desulfobacterales	28221|Deltaproteobacteria	L	TIGRFAM DNA topoisomerase III, bacteria and conjugative plasmid	-	-	5.99.1.2	ko:K03169	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	Topoisom_bac,Toprim,Toprim_Crpt,zf-C4_Topoisom
HKD2_k127_5589917_5	1121403.AUCV01000012_gene4069	3.87e-54	194.0	COG0799@1|root,COG0799@2|Bacteria,1MZEF@1224|Proteobacteria,42VN5@68525|delta/epsilon subdivisions,2WRGG@28221|Deltaproteobacteria,2MKMJ@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation	rsfS	-	-	ko:K09710	-	-	-	-	ko00000,ko03009	-	-	-	RsfS
HKD2_k127_5589917_2	1125863.JAFN01000001_gene3088	1.773e-194	622.0	COG0696@1|root,COG0696@2|Bacteria,1MUQ1@1224|Proteobacteria,42N6C@68525|delta/epsilon subdivisions,2WJ66@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate	gpmI	-	5.4.2.12	ko:K15633	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,Phosphodiest,iPGM_N
HKD2_k127_5589917_1	1121403.AUCV01000012_gene4070	1.852e-205	647.0	COG0498@1|root,COG0498@2|Bacteria,1MUWQ@1224|Proteobacteria,42MXQ@68525|delta/epsilon subdivisions,2WK2D@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	TIGRFAM Threonine synthase	thrC	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP,Thr_synth_N
HKD2_k127_5589917_4	1167006.UWK_00024	6.215e-103	346.0	COG0005@1|root,COG0005@2|Bacteria,1R7BS@1224|Proteobacteria,42ZMM@68525|delta/epsilon subdivisions,2WUWV@28221|Deltaproteobacteria,2MPH3@213118|Desulfobacterales	28221|Deltaproteobacteria	F	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate	deoD	-	2.4.2.1	ko:K03783	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R01561,R01863,R01969,R02147,R02294,R02295,R02297,R02484,R02557,R02748,R08368,R10244	RC00033,RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	PNP_UDP_1
HKD2_k127_5589917_3	1121403.AUCV01000012_gene4072	9.629e-194	613.0	COG0402@1|root,COG0402@2|Bacteria,1MVPA@1224|Proteobacteria,42NI6@68525|delta/epsilon subdivisions,2WKI1@28221|Deltaproteobacteria,2MJDX@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine	mtaD	-	3.5.4.28,3.5.4.31	ko:K12960	ko00270,ko01100,map00270,map01100	-	R09660	RC00477	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
HKD2_k127_5624882_0	1123242.JH636435_gene2937	1.48e-84	287.0	COG2227@1|root,COG2227@2|Bacteria	2|Bacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25,Methyltransf_31
HKD2_k127_5624882_1	234267.Acid_7801	4.314e-42	162.0	COG4430@1|root,COG4430@2|Bacteria,3Y5HF@57723|Acidobacteria	57723|Acidobacteria	S	Bacteriocin-protection, YdeI or OmpD-Associated	-	-	-	-	-	-	-	-	-	-	-	-	OmdA
HKD2_k127_5644255_3	398767.Glov_1392	4.901e-60	210.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJVV@28221|Deltaproteobacteria,43U04@69541|Desulfuromonadales	28221|Deltaproteobacteria	V	TIGRFAM transporter, hydrophobe amphiphile efflux-1 (HAE1) family	-	-	-	ko:K03296,ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
HKD2_k127_5644255_1	398767.Glov_1393	2.71e-155	505.0	COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,42NKZ@68525|delta/epsilon subdivisions,2WK44@28221|Deltaproteobacteria,43THY@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	TIGRFAM RND efflux system, outer membrane lipoprotein, NodT family	-	-	-	ko:K18139	ko01501,ko02024,map01501,map02024	M00642,M00643,M00647,M00718,M00768,M00822	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	1.B.17,2.A.6.2	-	-	MFS_1,OEP
HKD2_k127_5644255_0	1265505.ATUG01000002_gene1059	3.977e-164	543.0	COG0784@1|root,COG4191@1|root,COG0784@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42M1R@68525|delta/epsilon subdivisions,2WK3J@28221|Deltaproteobacteria,2MI5F@213118|Desulfobacterales	28221|Deltaproteobacteria	T	histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg,SBP_bac_3
HKD2_k127_5644255_2	1265505.ATUG01000002_gene1661	4.647e-88	299.0	COG2145@1|root,COG2145@2|Bacteria,1MVES@1224|Proteobacteria,42PAR@68525|delta/epsilon subdivisions,2WMWU@28221|Deltaproteobacteria,2MJHN@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)	thiM	-	2.7.1.50	ko:K00878	ko00730,ko01100,map00730,map01100	M00127	R04448	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	HK
HKD2_k127_56498_14	1121878.AUGL01000008_gene1411	2.231e-15	87.0	COG4676@1|root,COG4676@2|Bacteria,1R84A@1224|Proteobacteria,1S1CN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF2135
HKD2_k127_56498_17	321332.CYB_2053	2.178e-08	64.0	2BZXA@1|root,33P5U@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_56498_7	1121403.AUCV01000005_gene276	4.021e-94	318.0	COG4974@1|root,COG4974@2|Bacteria,1MVNF@1224|Proteobacteria,42N0M@68525|delta/epsilon subdivisions,2WJ7D@28221|Deltaproteobacteria,2MHZH@213118|Desulfobacterales	28221|Deltaproteobacteria	L	TIGRFAM tyrosine recombinase XerD	xerD	-	-	ko:K03733,ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
HKD2_k127_56498_13	1121403.AUCV01000005_gene277	4.071e-25	105.0	COG0828@1|root,COG0828@2|Bacteria	2|Bacteria	J	Belongs to the bacterial ribosomal protein bS21 family	rpsU	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:1990904	-	ko:K02970	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S21
HKD2_k127_56498_1	177439.DP0059	1.323e-171	550.0	COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,42M0V@68525|delta/epsilon subdivisions,2WIQ1@28221|Deltaproteobacteria,2MI3F@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM FAD linked oxidase domain protein	larD	-	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	iAF987.Gmet_3245	FAD-oxidase_C,FAD_binding_4
HKD2_k127_56498_2	1121403.AUCV01000005_gene278	3.095e-136	441.0	COG1181@1|root,COG1181@2|Bacteria,1MUTB@1224|Proteobacteria,42NF2@68525|delta/epsilon subdivisions,2WJ7Q@28221|Deltaproteobacteria,2MI9U@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Belongs to the D-alanine--D-alanine ligase family	ddl	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C,Dala_Dala_lig_N
HKD2_k127_56498_12	1121403.AUCV01000004_gene2061	1.104e-30	127.0	COG5608@1|root,COG5608@2|Bacteria,1Q3JI@1224|Proteobacteria,42XEN@68525|delta/epsilon subdivisions,2WSWH@28221|Deltaproteobacteria,2MQ1I@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Late embryogenesis abundant protein	-	-	-	-	-	-	-	-	-	-	-	-	LEA_2
HKD2_k127_56498_4	517418.Ctha_1656	5.335e-133	427.0	COG0450@1|root,COG0450@2|Bacteria,1FDZ0@1090|Chlorobi	1090|Chlorobi	O	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides	-	-	1.11.1.15	ko:K03386	ko04214,map04214	-	-	-	ko00000,ko00001,ko01000,ko04147	-	-	-	1-cysPrx_C,AhpC-TSA
HKD2_k127_56498_0	1121403.AUCV01000005_gene279	3.285e-211	662.0	COG0172@1|root,COG0172@2|Bacteria,1MUJF@1224|Proteobacteria,42M7H@68525|delta/epsilon subdivisions,2WIT7@28221|Deltaproteobacteria,2MI2A@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iAF987.Gmet_3528	Seryl_tRNA_N,tRNA-synt_2b
HKD2_k127_56498_8	1167006.UWK_01857	2.804e-81	280.0	COG0805@1|root,COG0805@2|Bacteria,1NZ7P@1224|Proteobacteria,430II@68525|delta/epsilon subdivisions,2WVTS@28221|Deltaproteobacteria	28221|Deltaproteobacteria	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides	-	-	-	ko:K03118	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	TatC
HKD2_k127_56498_10	1121403.AUCV01000005_gene281	1.312e-39	153.0	COG1683@1|root,COG1683@2|Bacteria,1RHER@1224|Proteobacteria,42TQ2@68525|delta/epsilon subdivisions,2WRQB@28221|Deltaproteobacteria,2MPVF@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF523)	-	-	-	-	-	-	-	-	-	-	-	-	DUF523
HKD2_k127_56498_16	1121403.AUCV01000005_gene282	2.823e-11	68.0	COG2919@1|root,COG2919@2|Bacteria,1NM5U@1224|Proteobacteria,42X2K@68525|delta/epsilon subdivisions,2WSPM@28221|Deltaproteobacteria	28221|Deltaproteobacteria	D	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic	divIC	-	-	ko:K05589,ko:K13052	-	-	-	-	ko00000,ko03036	-	-	-	DivIC
HKD2_k127_56498_9	1167006.UWK_01861	1.502e-41	164.0	COG1573@1|root,COG1573@2|Bacteria,1MWX1@1224|Proteobacteria,42QXV@68525|delta/epsilon subdivisions,2WS71@28221|Deltaproteobacteria,2MKXZ@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Uracil DNA glycosylase superfamily	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
HKD2_k127_56498_3	1121403.AUCV01000020_gene3137	4.174e-136	439.0	COG0761@1|root,COG0761@2|Bacteria,1MU7G@1224|Proteobacteria,42MJK@68525|delta/epsilon subdivisions,2WJ8V@28221|Deltaproteobacteria,2MI49@213118|Desulfobacterales	28221|Deltaproteobacteria	IM	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis	ispH	-	1.17.7.4	ko:K02945,ko:K03527	ko00900,ko01100,ko01110,ko01130,ko03010,map00900,map01100,map01110,map01130,map03010	M00096,M00178	R05884,R08210	RC01137,RC01487	br01610,ko00000,ko00001,ko00002,ko01000,ko03011	-	-	-	LYTB,UbiA
HKD2_k127_56498_11	56780.SYN_03116	1.131e-32	143.0	2C1G6@1|root,32R8K@2|Bacteria,1MYA0@1224|Proteobacteria,42T91@68525|delta/epsilon subdivisions,2WPK6@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_56498_6	1167006.UWK_01884	4.163e-104	355.0	COG0477@1|root,COG2814@2|Bacteria,1QUAS@1224|Proteobacteria,42PDB@68525|delta/epsilon subdivisions,2WJBQ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	EGP	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD2_k127_56498_5	1121403.AUCV01000020_gene3127	4.547e-130	426.0	COG0745@1|root,COG4191@1|root,COG0745@2|Bacteria,COG4191@2|Bacteria,1R13R@1224|Proteobacteria,43D5Z@68525|delta/epsilon subdivisions,2X8CS@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HATPase_c,HisKA,Response_reg
HKD2_k127_5711522_1	706587.Desti_5047	2.774e-127	434.0	COG0745@1|root,COG0784@1|root,COG5002@1|root,COG0745@2|Bacteria,COG0784@2|Bacteria,COG5002@2|Bacteria,1NC9X@1224|Proteobacteria,43BSJ@68525|delta/epsilon subdivisions,2X73B@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_9,Response_reg
HKD2_k127_5711522_0	1123371.ATXH01000009_gene1091	3.824e-177	566.0	COG0004@1|root,COG0004@2|Bacteria,2GH8U@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	P	Ammonium Transporter Family	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
HKD2_k127_5731448_1	1121335.Clst_0802	1.25e-18	97.0	COG1266@1|root,COG1266@2|Bacteria,1V1B4@1239|Firmicutes,25CEY@186801|Clostridia	186801|Clostridia	S	PFAM Abortive infection protein	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
HKD2_k127_5731448_0	357808.RoseRS_0453	7.296e-47	174.0	COG0640@1|root,COG3860@1|root,COG0640@2|Bacteria,COG3860@2|Bacteria,2G8TH@200795|Chloroflexi,377X2@32061|Chloroflexia	32061|Chloroflexia	K	Uncharacterized protein conserved in bacteria (DUF2087)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2087,HTH_5
HKD2_k127_573976_1	589865.DaAHT2_2039	6.663e-35	136.0	COG0637@1|root,COG0637@2|Bacteria,1QW0J@1224|Proteobacteria,43BQD@68525|delta/epsilon subdivisions,2X71F@28221|Deltaproteobacteria,2MPIT@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
HKD2_k127_573976_0	1121403.AUCV01000005_gene311	1.067e-54	199.0	COG0664@1|root,COG0664@2|Bacteria	2|Bacteria	T	cyclic nucleotide binding	-	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	DUF4388,TPR_6,cNMP_binding
HKD2_k127_573976_3	1121403.AUCV01000005_gene310	1.048e-31	127.0	COG0457@1|root,COG5078@1|root,COG0457@2|Bacteria,COG5078@2|Bacteria,1P62E@1224|Proteobacteria,432N1@68525|delta/epsilon subdivisions,2WY4Y@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	PFAM Ubiquitin-conjugating	-	-	-	-	-	-	-	-	-	-	-	-	UQ_con
HKD2_k127_5742015_1	1121403.AUCV01000033_gene3648	6.257e-105	356.0	COG1305@1|root,COG1305@2|Bacteria,1MWCE@1224|Proteobacteria,42NIZ@68525|delta/epsilon subdivisions,2WM5U@28221|Deltaproteobacteria,2MIWN@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Domain of unknown function (DUF3488)	-	-	2.3.2.13	ko:K22452	-	-	-	-	ko00000,ko01000	-	-	-	DUF3488,DUF4129,Transglut_core
HKD2_k127_5742015_0	1041139.KB902679_gene1961	3.486e-111	375.0	COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,1MV1V@1224|Proteobacteria,2U6VS@28211|Alphaproteobacteria,4BM30@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	Adenylate cyclase	cyaK	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	CHASE2,Guanylate_cyc
HKD2_k127_5783407_7	1121403.AUCV01000001_gene956	5.335e-22	99.0	COG0642@1|root,COG2205@2|Bacteria,1QHXX@1224|Proteobacteria,42NW1@68525|delta/epsilon subdivisions,2WJUF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	PFAM ATP-binding region, ATPase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c
HKD2_k127_5783407_4	1121403.AUCV01000001_gene955	3.677e-72	248.0	COG2065@1|root,COG2065@2|Bacteria,1RI6U@1224|Proteobacteria,42S2E@68525|delta/epsilon subdivisions,2WMT9@28221|Deltaproteobacteria,2MITJ@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant	pyrR	-	2.4.2.9	ko:K02825	ko00240,ko01100,map00240,map01100	-	R00966	RC00063	ko00000,ko00001,ko01000,ko03000	-	-	-	Pribosyltran
HKD2_k127_5783407_3	177439.DP1615	9.837e-86	288.0	COG0299@1|root,COG0299@2|Bacteria,1MWN1@1224|Proteobacteria,42R30@68525|delta/epsilon subdivisions,2WJT0@28221|Deltaproteobacteria,2MJ3P@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate	purN	-	2.1.2.2	ko:K11175	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	M00048	R04325,R04326	RC00026,RC00197,RC01128	ko00000,ko00001,ko00002,ko01000	-	-	-	Formyl_trans_N
HKD2_k127_5783407_1	1167006.UWK_02924	1.035e-96	322.0	COG0138@1|root,COG0138@2|Bacteria,1MUDQ@1224|Proteobacteria,42MV4@68525|delta/epsilon subdivisions,2WMW3@28221|Deltaproteobacteria,2MPF8@213118|Desulfobacterales	28221|Deltaproteobacteria	F	MGS-like domain	-	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AICARFT_IMPCHas,MGS
HKD2_k127_5783407_5	1121403.AUCV01000001_gene952	1.277e-32	131.0	COG1188@1|root,COG1188@2|Bacteria,1MZR6@1224|Proteobacteria,4316A@68525|delta/epsilon subdivisions	1224|Proteobacteria	J	S4 RNA-binding domain	hslR	GO:0003674,GO:0003676,GO:0003677,GO:0003723,GO:0003727,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009266,GO:0009408,GO:0009451,GO:0009628,GO:0009987,GO:0016070,GO:0033554,GO:0034605,GO:0034641,GO:0043021,GO:0043023,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363	-	ko:K04762	-	-	-	-	ko00000,ko03110	-	-	-	S4
HKD2_k127_5783407_2	1121403.AUCV01000001_gene951	1.054e-94	317.0	COG1469@1|root,COG1469@2|Bacteria,1MV1B@1224|Proteobacteria,42N4U@68525|delta/epsilon subdivisions,2WJR7@28221|Deltaproteobacteria,2MHSN@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Converts GTP to 7,8-dihydroneopterin triphosphate	folE2	-	3.5.4.16	ko:K09007	ko00790,ko01100,map00790,map01100	M00126	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	-	GCHY-1
HKD2_k127_5783407_0	398767.Glov_1691	5.505e-221	694.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,42N0C@68525|delta/epsilon subdivisions,2WJQQ@28221|Deltaproteobacteria,43TF1@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	belongs to the aldehyde dehydrogenase family	gabD	-	1.2.1.16,1.2.1.20,1.2.1.79	ko:K00135	ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120	M00027	R00713,R00714,R02401	RC00080	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_3395	Aldedh
HKD2_k127_5804316_4	1121403.AUCV01000026_gene2366	1.312e-29	127.0	COG0427@1|root,COG1670@1|root,COG0427@2|Bacteria,COG1670@2|Bacteria,1MUGE@1224|Proteobacteria,42MHC@68525|delta/epsilon subdivisions,2WINZ@28221|Deltaproteobacteria,2MI87@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM Acetyl-CoA hydrolase transferase	-	-	-	-	-	-	-	-	-	-	-	-	AcetylCoA_hyd_C,AcetylCoA_hydro,Acetyltransf_1,Acetyltransf_3
HKD2_k127_5804316_0	589865.DaAHT2_1111	4.321e-292	911.0	COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,42KZW@68525|delta/epsilon subdivisions,2WIQB@28221|Deltaproteobacteria,2MIWX@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM CoA-binding domain protein	-	-	6.2.1.13	ko:K01905,ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
HKD2_k127_5804316_2	1121403.AUCV01000026_gene2364	3.815e-62	221.0	COG0517@1|root,COG0517@2|Bacteria,1PDG6@1224|Proteobacteria,42QQ0@68525|delta/epsilon subdivisions,2WMQ6@28221|Deltaproteobacteria,2MKN2@213118|Desulfobacterales	28221|Deltaproteobacteria	S	PFAM CBS domain	-	-	-	ko:K04767	-	-	-	-	ko00000	-	-	-	CBS
HKD2_k127_5804316_1	1167006.UWK_02598	1.807e-112	372.0	COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,42NQP@68525|delta/epsilon subdivisions,2WIQD@28221|Deltaproteobacteria,2MJIG@213118|Desulfobacterales	28221|Deltaproteobacteria	BQ	PFAM Histone deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
HKD2_k127_5804316_3	706587.Desti_0667	1.905e-60	225.0	COG4314@1|root,COG4314@2|Bacteria,1RID8@1224|Proteobacteria,42SYX@68525|delta/epsilon subdivisions,2WPEE@28221|Deltaproteobacteria,2MSFE@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	NosL	-	-	-	-	-	-	-	-	-	-	-	-	NosL
HKD2_k127_5804316_6	177439.DP2832	1.693e-11	70.0	COG0526@1|root,COG0526@2|Bacteria	2|Bacteria	CO	cell redox homeostasis	-	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
HKD2_k127_5817198_6	589865.DaAHT2_1160	1.42e-31	127.0	COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,42M5E@68525|delta/epsilon subdivisions,2WIV6@28221|Deltaproteobacteria,2MISJ@213118|Desulfobacterales	28221|Deltaproteobacteria	J	ribonuclease Rne Rng family	cafA	-	3.1.26.12	ko:K08300,ko:K08301	ko03018,map03018	M00394	-	-	ko00000,ko00001,ko00002,ko01000,ko03009,ko03019	-	-	-	RNase_E_G,S1
HKD2_k127_5817198_4	1121403.AUCV01000010_gene1410	2.393e-91	310.0	COG0463@1|root,COG0463@2|Bacteria,1N8QE@1224|Proteobacteria,43BJ3@68525|delta/epsilon subdivisions,2WRX6@28221|Deltaproteobacteria,2MPKP@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HKD2_k127_5817198_3	589865.DaAHT2_0828	6.948e-154	490.0	COG0190@1|root,COG0190@2|Bacteria,1MWU4@1224|Proteobacteria,42MW0@68525|delta/epsilon subdivisions,2WJ90@28221|Deltaproteobacteria,2MHRX@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate	folD	-	1.5.1.5,3.5.4.9	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R01220,R01655	RC00202,RC00578	ko00000,ko00001,ko00002,ko01000	-	-	-	THF_DHG_CYH,THF_DHG_CYH_C
HKD2_k127_5817198_1	1167006.UWK_03164	0.0	1116.0	COG0369@1|root,COG1151@2|Bacteria,1NYH2@1224|Proteobacteria,42NE1@68525|delta/epsilon subdivisions,2WIVX@28221|Deltaproteobacteria,2MHKH@213118|Desulfobacterales	28221|Deltaproteobacteria	C	TIGRFAM carbon-monoxide dehydrogenase, catalytic subunit	-	-	1.2.7.4	ko:K00198	ko00633,ko00680,ko00720,ko01120,ko01200,map00633,map00680,map00720,map01120,map01200	M00377	R07157,R08034	RC00250,RC02800	ko00000,ko00001,ko00002,ko01000	-	-	-	Prismane
HKD2_k127_5817198_2	589865.DaAHT2_0826	0.0	1116.0	COG0685@1|root,COG2069@1|root,COG0685@2|Bacteria,COG2069@2|Bacteria,1MXTZ@1224|Proteobacteria,42NTS@68525|delta/epsilon subdivisions,2WK04@28221|Deltaproteobacteria,2MIIA@213118|Desulfobacterales	28221|Deltaproteobacteria	E	PFAM Methylenetetrahydrofolate reductase	-	-	1.5.1.20,2.1.1.10	ko:K00297,ko:K00547	ko00270,ko00670,ko00720,ko01100,ko01110,ko01120,ko01200,ko01523,map00270,map00670,map00720,map01100,map01110,map01120,map01200,map01523	M00377	R00650,R01224,R07168	RC00003,RC00035,RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	CdhD,MTHFR
HKD2_k127_5817198_0	1167006.UWK_03162	0.0	1317.0	COG1614@1|root,COG1614@2|Bacteria,1MVI5@1224|Proteobacteria,42N9A@68525|delta/epsilon subdivisions,2WK4H@28221|Deltaproteobacteria,2MIRV@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM CO dehydrogenase acetyl-CoA synthase complex beta subunit	-	-	2.3.1.169	ko:K14138	ko00720,ko01120,ko01200,map00720,map01120,map01200	M00377	R08433,R10243	RC00004,RC00113,RC01144,RC02963,RC02964,RC02977	ko00000,ko00001,ko00002,ko01000	-	-	-	CdhC
HKD2_k127_5817198_5	589865.DaAHT2_0824	3.534e-84	285.0	COG1456@1|root,COG1456@2|Bacteria,1R4RE@1224|Proteobacteria,42M89@68525|delta/epsilon subdivisions,2WJVQ@28221|Deltaproteobacteria,2MI7W@213118|Desulfobacterales	28221|Deltaproteobacteria	C	CO dehydrogenase acetyl-CoA synthase delta subunit	-	-	2.1.1.245	ko:K00197	ko00680,ko00720,ko01120,ko01200,map00680,map00720,map01120,map01200	M00357,M00377,M00422	R09096,R10219,R10243	RC00004,RC00113,RC02977	ko00000,ko00001,ko00002,ko01000	-	-	-	CdhD,FeS
HKD2_k127_5817745_2	1167006.UWK_01419	6.491e-36	141.0	COG0599@1|root,COG0599@2|Bacteria,1N2ZQ@1224|Proteobacteria,42VDR@68525|delta/epsilon subdivisions,2WRKS@28221|Deltaproteobacteria,2MPA2@213118|Desulfobacterales	28221|Deltaproteobacteria	S	PFAM Carboxymuconolactone decarboxylase	-	-	-	-	-	-	-	-	-	-	-	-	CMD
HKD2_k127_5817745_4	1121403.AUCV01000012_gene4074	5.412e-15	77.0	COG1826@1|root,COG1826@2|Bacteria,1Q1PB@1224|Proteobacteria,437DB@68525|delta/epsilon subdivisions,2WX7X@28221|Deltaproteobacteria	28221|Deltaproteobacteria	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system	-	-	-	ko:K03116	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
HKD2_k127_5817745_1	589865.DaAHT2_0012	3.575e-50	188.0	arCOG10218@1|root,320QR@2|Bacteria,1N5AN@1224|Proteobacteria,42U1Q@68525|delta/epsilon subdivisions,2WQ6Y@28221|Deltaproteobacteria,2MPQS@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Putative redox-active protein (C_GCAxxG_C_C)	-	-	-	-	-	-	-	-	-	-	-	-	C_GCAxxG_C_C
HKD2_k127_5817745_0	1121403.AUCV01000044_gene40	3.508e-235	740.0	COG1032@1|root,COG1032@2|Bacteria,1MUG3@1224|Proteobacteria,42N0P@68525|delta/epsilon subdivisions,2WJCQ@28221|Deltaproteobacteria,2MI60@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	DUF3362,Radical_SAM,Radical_SAM_N
HKD2_k127_5817745_3	589865.DaAHT2_1972	9.459e-18	89.0	COG1032@1|root,COG1032@2|Bacteria,1Q5NG@1224|Proteobacteria,42N2D@68525|delta/epsilon subdivisions,2WUXJ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	radical SAM	-	-	1.21.98.3	ko:K04034	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R06268,R06269,R06270	RC00741,RC01491,RC01492	ko00000,ko00001,ko01000	-	-	-	DUF4080,Radical_SAM
HKD2_k127_5839447_7	1121403.AUCV01000017_gene4473	1.192e-64	224.0	COG1475@1|root,COG1475@2|Bacteria,1MW2E@1224|Proteobacteria,42M8S@68525|delta/epsilon subdivisions,2WNG8@28221|Deltaproteobacteria,2MIMS@213118|Desulfobacterales	28221|Deltaproteobacteria	K	Belongs to the ParB family	parB	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
HKD2_k127_5839447_5	1121403.AUCV01000017_gene4474	5.359e-105	347.0	COG1192@1|root,COG1192@2|Bacteria,1MV43@1224|Proteobacteria,42MTF@68525|delta/epsilon subdivisions,2WJ6X@28221|Deltaproteobacteria,2MHMY@213118|Desulfobacterales	28221|Deltaproteobacteria	D	PFAM CobQ CobB MinD ParA nucleotide binding domain	soj	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
HKD2_k127_5839447_1	96561.Dole_1490	5.084e-190	607.0	COG0029@1|root,COG0029@2|Bacteria,1RBQW@1224|Proteobacteria,43BKD@68525|delta/epsilon subdivisions,2WJNK@28221|Deltaproteobacteria,2MIMB@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Catalyzes the oxidation of L-aspartate to iminoaspartate	nadB	-	1.4.3.16	ko:K00278	ko00250,ko00760,ko01100,map00250,map00760,map01100	M00115	R00357,R00481	RC00006,RC02566	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
HKD2_k127_5839447_8	1167006.UWK_00812	1.095e-57	212.0	2E2FV@1|root,32XK0@2|Bacteria,1MZX8@1224|Proteobacteria,42U53@68525|delta/epsilon subdivisions,2WQRV@28221|Deltaproteobacteria,2MNHV@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5839447_0	1121403.AUCV01000017_gene4478	0.0	1176.0	COG1026@1|root,COG1026@2|Bacteria,1MVDJ@1224|Proteobacteria,42MRG@68525|delta/epsilon subdivisions,2WJ5Q@28221|Deltaproteobacteria,2MINB@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Peptidase M16C associated	PREP	-	-	ko:K06972	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M16C_assoc,Peptidase_M16,Peptidase_M16_C
HKD2_k127_5839447_9	1167006.UWK_01569	2.817e-53	191.0	COG1490@1|root,COG1490@2|Bacteria,1RGTV@1224|Proteobacteria,42SMU@68525|delta/epsilon subdivisions,2WP4P@28221|Deltaproteobacteria,2MK67@213118|Desulfobacterales	28221|Deltaproteobacteria	J	rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality	dtd	GO:0002161,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0051499,GO:0051500,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360	-	ko:K07560	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Tyr_Deacylase
HKD2_k127_5839447_10	1121403.AUCV01000017_gene4480	7.589e-52	195.0	COG1385@1|root,COG1385@2|Bacteria,1MXCU@1224|Proteobacteria,42R1A@68525|delta/epsilon subdivisions,2WMV6@28221|Deltaproteobacteria,2MJG5@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit	rsmE	-	2.1.1.193	ko:K09761	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_RNA
HKD2_k127_5839447_3	1121403.AUCV01000045_gene1137	2.208e-175	569.0	COG0535@1|root,COG0535@2|Bacteria,1R58E@1224|Proteobacteria,42NSA@68525|delta/epsilon subdivisions,2WJVH@28221|Deltaproteobacteria,2MJDY@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Fer4_14,Radical_SAM,SPASM
HKD2_k127_5839447_12	1562701.BBOF01000032_gene1142	1.36e-44	169.0	COG0262@1|root,COG0262@2|Bacteria,1RH0P@1224|Proteobacteria,2VSH8@28216|Betaproteobacteria,1K1KK@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis	folA	-	1.5.1.3	ko:K00287	ko00670,ko00790,ko01100,ko01523,map00670,map00790,map01100,map01523	M00126,M00840	R00936,R00937,R00939,R00940,R02235,R02236,R11765	RC00109,RC00110,RC00158	ko00000,ko00001,ko00002,ko01000	-	-	-	DHFR_1
HKD2_k127_5839447_11	1167006.UWK_00571	1.974e-45	171.0	COG0071@1|root,COG0071@2|Bacteria,1N7C7@1224|Proteobacteria,42U0T@68525|delta/epsilon subdivisions,2WQ7I@28221|Deltaproteobacteria,2MKG1@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
HKD2_k127_5839447_4	706587.Desti_3303	3.801e-146	473.0	COG0464@1|root,COG0464@2|Bacteria,1QFHD@1224|Proteobacteria,42QEP@68525|delta/epsilon subdivisions,2WIT4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	AAA ATPase, central domain protein	-	-	-	-	-	-	-	-	-	-	-	-	AAA,DUF4032
HKD2_k127_5839447_2	1121403.AUCV01000017_gene4482	6.552e-178	562.0	COG0468@1|root,COG0468@2|Bacteria,1MU3C@1224|Proteobacteria,42M69@68525|delta/epsilon subdivisions,2WIYC@28221|Deltaproteobacteria,2MI4Q@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage	recA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K03553	ko03440,map03440	M00729	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	RecA
HKD2_k127_5839447_6	589865.DaAHT2_1904	6.158e-100	336.0	COG1058@1|root,COG1546@1|root,COG1058@2|Bacteria,COG1546@2|Bacteria,1RH2Y@1224|Proteobacteria,42MQ4@68525|delta/epsilon subdivisions,2WMDT@28221|Deltaproteobacteria,2MHNR@213118|Desulfobacterales	28221|Deltaproteobacteria	S	TIGRFAM competence damage-inducible protein CinA	cinA	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363	3.5.1.42	ko:K03742,ko:K03743	ko00760,map00760	-	R02322	RC00100	ko00000,ko00001,ko01000	-	-	-	CinA,MoCF_biosynth
HKD2_k127_5862580_2	1167006.UWK_00224	2.658e-120	408.0	COG2951@1|root,COG2951@2|Bacteria,1MUZ3@1224|Proteobacteria,42MX3@68525|delta/epsilon subdivisions,2WKI4@28221|Deltaproteobacteria,2MI7Y@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Transglycosylase SLT domain	-	-	-	ko:K08305	-	-	-	-	ko00000,ko01000,ko01011	-	GH103	-	SLT_2
HKD2_k127_5862580_3	589865.DaAHT2_2252	2.129e-110	367.0	COG0618@1|root,COG0618@2|Bacteria,1R13S@1224|Proteobacteria	1224|Proteobacteria	S	3'(2'),5'-bisphosphate nucleotidase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5862580_0	1121403.AUCV01000004_gene2035	5.805e-264	834.0	COG1452@1|root,COG1452@2|Bacteria,1MUJC@1224|Proteobacteria,42N34@68525|delta/epsilon subdivisions,2WJUD@28221|Deltaproteobacteria,2MI31@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane	lptD	-	-	ko:K04744	-	-	-	-	ko00000,ko02000	1.B.42.1	-	iAF987.Gmet_2474	OstA,OstA_2,OstA_C
HKD2_k127_5862580_4	589865.DaAHT2_2249	5.17e-97	328.0	COG0731@1|root,COG0731@2|Bacteria,1QG36@1224|Proteobacteria,42M82@68525|delta/epsilon subdivisions,2WKGK@28221|Deltaproteobacteria,2MHYQ@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_14,Radical_SAM
HKD2_k127_5862580_1	1121403.AUCV01000004_gene2037	6.534e-240	759.0	COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,42M5E@68525|delta/epsilon subdivisions,2WIV6@28221|Deltaproteobacteria,2MIDU@213118|Desulfobacterales	28221|Deltaproteobacteria	J	TIGRFAM ribonuclease, Rne Rng family	rne	-	3.1.26.12	ko:K08300,ko:K08301	ko03018,map03018	M00394	-	-	ko00000,ko00001,ko00002,ko01000,ko03009,ko03019	-	-	-	RNase_E_G,S1
HKD2_k127_5862580_6	1087481.AGFX01000022_gene2243	5.736e-05	46.0	2BKI8@1|root,32EZF@2|Bacteria,1TZNM@1239|Firmicutes,4I8XU@91061|Bacilli,270PJ@186822|Paenibacillaceae	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5862580_5	290397.Adeh_3703	6.816e-19	87.0	COG4147@1|root,COG4147@2|Bacteria,1MVJ8@1224|Proteobacteria,42MJE@68525|delta/epsilon subdivisions,2WK5T@28221|Deltaproteobacteria,2YWIX@29|Myxococcales	28221|Deltaproteobacteria	S	Sodium:solute symporter family	aplA	-	-	ko:K14393	-	-	-	-	ko00000,ko02000	2.A.21.7	-	iAF987.Gmet_0739	SSF
HKD2_k127_5873156_1	1167006.UWK_02357	5.188e-93	308.0	COG0694@1|root,COG0822@1|root,COG1251@1|root,COG0694@2|Bacteria,COG0822@2|Bacteria,COG1251@2|Bacteria,1RD5K@1224|Proteobacteria,42MT6@68525|delta/epsilon subdivisions,2WJBU@28221|Deltaproteobacteria,2MIAE@213118|Desulfobacterales	28221|Deltaproteobacteria	C	May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins	nifU	-	-	ko:K04488,ko:K13819	-	-	-	-	ko00000	-	-	-	Fer2_BFD,NifU,NifU_N
HKD2_k127_5873156_0	1121403.AUCV01000001_gene968	4.662e-169	539.0	COG1109@1|root,COG1109@2|Bacteria,1QUGD@1224|Proteobacteria,43BUU@68525|delta/epsilon subdivisions,2WKYP@28221|Deltaproteobacteria,2MPVX@213118|Desulfobacterales	28221|Deltaproteobacteria	G	Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III	-	-	5.4.2.2,5.4.2.8	ko:K01835,ko:K01840	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114,M00549	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
HKD2_k127_5903132_4	1121403.AUCV01000001_gene949	4.632e-149	489.0	COG2114@1|root,COG2203@1|root,COG2114@2|Bacteria,COG2203@2|Bacteria,1RAHZ@1224|Proteobacteria,42UGY@68525|delta/epsilon subdivisions,2WQPI@28221|Deltaproteobacteria,2MNGQ@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	FHA,GAF,GAF_2,Guanylate_cyc
HKD2_k127_5903132_3	671143.DAMO_2552	5.312e-151	489.0	COG2256@1|root,COG2256@2|Bacteria,2NNTG@2323|unclassified Bacteria	2|Bacteria	L	MgsA AAA+ ATPase C terminal	rarA	-	-	ko:K07478	-	-	-	-	ko00000	-	-	-	AAA,AAA_assoc_2,MgsA_C,RuvB_N
HKD2_k127_5903132_8	215803.DB30_2297	5.803e-06	58.0	COG0737@1|root,COG0737@2|Bacteria,1NDBC@1224|Proteobacteria,42V2W@68525|delta/epsilon subdivisions,2WS9M@28221|Deltaproteobacteria,2YV8Z@29|Myxococcales	28221|Deltaproteobacteria	F	Cytochrome c554 and c-prime	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554
HKD2_k127_5903132_0	1232410.KI421421_gene3465	1.657e-281	872.0	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,42M2A@68525|delta/epsilon subdivisions,2WIJY@28221|Deltaproteobacteria,43S4H@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	ABC transporter	-	-	-	ko:K06158	-	-	-	-	ko00000,ko03012	-	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
HKD2_k127_5903132_2	1121403.AUCV01000001_gene946	1.827e-161	512.0	COG1227@1|root,COG1227@2|Bacteria,1P9JN@1224|Proteobacteria,42N0W@68525|delta/epsilon subdivisions,2WK0Q@28221|Deltaproteobacteria,2MI41@213118|Desulfobacterales	28221|Deltaproteobacteria	C	DHHA2	ppaC	-	3.6.1.1	ko:K15986	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	CBS,DHH,DHHA2,DRTGG
HKD2_k127_5903132_5	1167006.UWK_02486	7.353e-103	339.0	COG0670@1|root,COG0670@2|Bacteria,1MU69@1224|Proteobacteria,42MWD@68525|delta/epsilon subdivisions,2WMG9@28221|Deltaproteobacteria,2MJCA@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Belongs to the BI1 family	ybhL	-	-	ko:K06890,ko:K19416	-	M00742	-	-	ko00000,ko00002,ko02000	1.A.14.2.1	-	-	Bax1-I
HKD2_k127_5903132_6	1167006.UWK_02485	5.16e-93	325.0	COG3640@1|root,COG3640@2|Bacteria,1RB02@1224|Proteobacteria,42NBP@68525|delta/epsilon subdivisions,2WKS7@28221|Deltaproteobacteria,2MJA2@213118|Desulfobacterales	28221|Deltaproteobacteria	D	PFAM Cobyrinic acid ac-diamide synthase	cooC	-	-	ko:K07321	-	-	-	-	ko00000	-	-	-	CbiA
HKD2_k127_5903132_1	1167006.UWK_02484	1.071e-207	657.0	COG1086@1|root,COG2148@1|root,COG1086@2|Bacteria,COG2148@2|Bacteria,1MV6W@1224|Proteobacteria,42MZY@68525|delta/epsilon subdivisions,2WJWT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Sugar transferase	epsL	-	-	ko:K03606	ko05111,map05111	-	-	-	ko00000,ko00001	-	-	-	Bac_transf,CoA_binding_3
HKD2_k127_5925096_3	1121405.dsmv_1156	4.427e-25	108.0	COG0463@1|root,COG0463@2|Bacteria,1MXC1@1224|Proteobacteria,42PE4@68525|delta/epsilon subdivisions,2WK83@28221|Deltaproteobacteria,2MPWY@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Glycosyltransferase like family 2	-	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2
HKD2_k127_5925096_2	1121403.AUCV01000007_gene1253	6.443e-116	383.0	COG0494@1|root,COG1194@1|root,COG0494@2|Bacteria,COG1194@2|Bacteria,1MUD4@1224|Proteobacteria,42PDR@68525|delta/epsilon subdivisions,2WJ60@28221|Deltaproteobacteria,2MI2R@213118|Desulfobacterales	28221|Deltaproteobacteria	L	A G-specific adenine glycosylase	mutY	-	-	ko:K03575	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD,NUDIX_4
HKD2_k127_5925096_0	765912.Thimo_3101	5.616e-173	554.0	COG2807@1|root,COG2807@2|Bacteria,1QW3Y@1224|Proteobacteria,1T2RW@1236|Gammaproteobacteria,1X2P1@135613|Chromatiales	135613|Chromatiales	P	PFAM Major Facilitator Superfamily	-	-	-	ko:K08218	ko01501,map01501	M00628	-	-	ko00000,ko00001,ko00002,ko02000	2.A.1.25	-	-	MFS_1
HKD2_k127_5925096_1	1167006.UWK_02241	3.061e-120	389.0	COG0215@1|root,COG0215@2|Bacteria,1MV8H@1224|Proteobacteria,42M04@68525|delta/epsilon subdivisions,2WJJD@28221|Deltaproteobacteria,2MIN7@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e,tRNA-synt_1g
HKD2_k127_5958682_0	1121405.dsmv_1339	0.0	1543.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJVV@28221|Deltaproteobacteria,2MI7E@213118|Desulfobacterales	28221|Deltaproteobacteria	V	Hydrophobe Amphiphile Efflux-1 (HAE1) Family	acrB	-	-	ko:K03296,ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
HKD2_k127_5963455_1	177439.DP1795	5.062e-88	308.0	COG0157@1|root,COG0157@2|Bacteria,1MW0C@1224|Proteobacteria,42MY7@68525|delta/epsilon subdivisions,2WJH7@28221|Deltaproteobacteria,2MIBN@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Belongs to the NadC ModD family	nadC	-	2.4.2.19	ko:K00767	ko00760,ko01100,map00760,map01100	M00115	R03348	RC02877	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_1988	QRPTase_C,QRPTase_N
HKD2_k127_5963455_0	1121403.AUCV01000001_gene857	5.505e-267	831.0	COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,42MPZ@68525|delta/epsilon subdivisions,2WIR9@28221|Deltaproteobacteria,2MHQG@213118|Desulfobacterales	28221|Deltaproteobacteria	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
HKD2_k127_5980485_1	392500.Swoo_3530	2.129e-137	448.0	COG1404@1|root,COG1404@2|Bacteria,1MU3S@1224|Proteobacteria,1RQAA@1236|Gammaproteobacteria,2QEJZ@267890|Shewanellaceae	1236|Gammaproteobacteria	M	PFAM peptidase S8 and S53 subtilisin kexin sedolisin	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
HKD2_k127_5980485_4	563040.Saut_0751	1.911e-44	165.0	2B3E9@1|root,31W34@2|Bacteria,1MZ95@1224|Proteobacteria,42U85@68525|delta/epsilon subdivisions,2YQ41@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5980485_3	177439.DP2156	9.069e-98	329.0	COG4294@1|root,COG4294@2|Bacteria,1R4A5@1224|Proteobacteria,42PP4@68525|delta/epsilon subdivisions,2WKIU@28221|Deltaproteobacteria,2MK1U@213118|Desulfobacterales	28221|Deltaproteobacteria	L	UV-endonuclease UvdE	uvsE	-	-	ko:K13281	-	-	-	-	ko00000,ko01000	-	-	-	DUF1722,UvdE
HKD2_k127_5980485_2	1121403.AUCV01000059_gene3338	1.883e-126	416.0	COG0628@1|root,COG0628@2|Bacteria,1NG06@1224|Proteobacteria,42RH3@68525|delta/epsilon subdivisions,2WUIC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Transmembrane protein 43	-	-	-	-	-	-	-	-	-	-	-	-	TMEM43
HKD2_k127_5980485_0	1167006.UWK_02795	9.266e-161	520.0	COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,42M88@68525|delta/epsilon subdivisions,2WIZI@28221|Deltaproteobacteria,2MJ2S@213118|Desulfobacterales	28221|Deltaproteobacteria	T	PFAM sigma-54 factor interaction domain-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,PAS_9,Sigma54_activat
HKD2_k127_6009144_0	1167006.UWK_02849	1.81e-54	201.0	COG0351@1|root,COG0351@2|Bacteria,1MU9J@1224|Proteobacteria,42N1F@68525|delta/epsilon subdivisions,2WK2V@28221|Deltaproteobacteria,2MI0R@213118|Desulfobacterales	28221|Deltaproteobacteria	H	PFAM Phosphomethylpyrimidine kinase	thiD	-	2.5.1.3,2.7.1.49,2.7.4.7	ko:K00941,ko:K14153,ko:K21219	ko00730,ko01100,map00730,map01100	M00127	R03223,R03471,R04509,R10712	RC00002,RC00017,RC00224,RC03255,RC03397	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2909	Phos_pyr_kin,TMP-TENI,ThiP_synth
HKD2_k127_6009144_1	589865.DaAHT2_0236	6.868e-52	188.0	COG1047@1|root,COG1047@2|Bacteria,1RD35@1224|Proteobacteria,42MCS@68525|delta/epsilon subdivisions,2WQGI@28221|Deltaproteobacteria,2MK26@213118|Desulfobacterales	28221|Deltaproteobacteria	O	peptidyl-prolyl cis-trans isomerase	-	-	5.2.1.8	ko:K01802	-	-	-	-	ko00000,ko01000	-	-	-	FKBP_C
HKD2_k127_6011731_1	314230.DSM3645_13890	2.687e-69	241.0	COG3271@1|root,COG3271@2|Bacteria,2J35W@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6011731_2	1121403.AUCV01000027_gene2469	2.663e-16	87.0	2EJWV@1|root,33DMJ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6011731_0	1121403.AUCV01000004_gene2012	4.798e-248	769.0	COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,42NDG@68525|delta/epsilon subdivisions,2WKYU@28221|Deltaproteobacteria,2MISU@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA1	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
HKD2_k127_6030715_0	1121403.AUCV01000020_gene3088	1.152e-138	447.0	COG0463@1|root,COG0463@2|Bacteria,1MWE5@1224|Proteobacteria,42MCE@68525|delta/epsilon subdivisions,2WIYP@28221|Deltaproteobacteria,2MMID@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Glycosyltransferase like family 2	-	-	2.4.2.53	ko:K10012	ko00520,ko01503,map00520,map01503	M00721,M00761	R07661	RC00005,RC02954	ko00000,ko00001,ko00002,ko01000,ko01005,ko02000	4.D.2.1.8	GT2	-	Glycos_transf_2
HKD2_k127_6030715_1	1167006.UWK_02481	3.716e-116	380.0	COG1216@1|root,COG1216@2|Bacteria,1QXPI@1224|Proteobacteria,43C5D@68525|delta/epsilon subdivisions,2X7YV@28221|Deltaproteobacteria,2MPKW@213118|Desulfobacterales	28221|Deltaproteobacteria	S	PFAM Glycosyl transferase family 2	-	-	-	ko:K07011	-	-	-	-	ko00000	-	-	-	Glycos_transf_2
HKD2_k127_6070613_2	1167006.UWK_01771	2.761e-187	590.0	COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,42MFT@68525|delta/epsilon subdivisions,2WIXC@28221|Deltaproteobacteria,2MHRV@213118|Desulfobacterales	28221|Deltaproteobacteria	P	TIGRFAM ammonium transporter	amt	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
HKD2_k127_6070613_3	1123371.ATXH01000010_gene725	7.587e-51	182.0	COG0347@1|root,COG0347@2|Bacteria,2GHW8@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	K	nitrogen regulatory protein P-II	-	-	-	ko:K04751	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	P-II
HKD2_k127_6070613_0	1121403.AUCV01000027_gene2511	1.817e-313	984.0	COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,42MN5@68525|delta/epsilon subdivisions,2WINN@28221|Deltaproteobacteria,2MI1W@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen	glnD	-	2.7.7.59	ko:K00990	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	-	-	-	ACT,DUF294,GlnD_UR_UTase,GlnE,HD,NTP_transf_2
HKD2_k127_6070613_1	1121918.ARWE01000001_gene96	6.922e-229	713.0	COG0174@1|root,COG0174@2|Bacteria,1MUGQ@1224|Proteobacteria,42M7A@68525|delta/epsilon subdivisions,2WJ8P@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	PFAM Glutamine synthetase, catalytic	glnA2	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
HKD2_k127_6127440_3	1167006.UWK_01254	1.054e-63	229.0	COG1309@1|root,COG1309@2|Bacteria,1MYVR@1224|Proteobacteria,42SV2@68525|delta/epsilon subdivisions,2WPSA@28221|Deltaproteobacteria,2MPEM@213118|Desulfobacterales	28221|Deltaproteobacteria	K	PFAM Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
HKD2_k127_6127440_1	1121403.AUCV01000028_gene2442	1.346e-138	455.0	COG1538@1|root,COG1538@2|Bacteria,1QFYM@1224|Proteobacteria,42RBK@68525|delta/epsilon subdivisions,2WMSG@28221|Deltaproteobacteria,2MJM2@213118|Desulfobacterales	28221|Deltaproteobacteria	MU	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
HKD2_k127_6127440_2	243231.GSU2517	5.202e-101	345.0	COG0247@1|root,COG2897@1|root,COG0247@2|Bacteria,COG2897@2|Bacteria,1NKKI@1224|Proteobacteria,42NPC@68525|delta/epsilon subdivisions,2WJ4N@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Cysteine-rich domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_17,Fer4_8,SNARE_assoc
HKD2_k127_6127440_0	1121403.AUCV01000004_gene1985	4.283e-154	501.0	COG2204@1|root,COG3829@1|root,COG3852@1|root,COG2204@2|Bacteria,COG3829@2|Bacteria,COG3852@2|Bacteria,1QW3X@1224|Proteobacteria	1224|Proteobacteria	T	PAS domain containing protein	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg,SpoIIE
HKD2_k127_6142920_2	1249480.B649_06140	7.571e-45	179.0	COG2982@1|root,COG2982@2|Bacteria,1QA6E@1224|Proteobacteria,42NCN@68525|delta/epsilon subdivisions,2YM89@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	M	AsmA-like C-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	AsmA_1,DUF3971
HKD2_k127_6142920_3	1265505.ATUG01000002_gene2210	9.629e-07	57.0	COG0484@1|root,COG0484@2|Bacteria,1R09D@1224|Proteobacteria,43ED2@68525|delta/epsilon subdivisions,2X801@28221|Deltaproteobacteria,2MKCC@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Class III cytochrome C family	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_CIII
HKD2_k127_6142920_1	243231.GSU0366	1.901e-56	209.0	COG1396@1|root,COG1396@2|Bacteria,1NV5J@1224|Proteobacteria,42ZQW@68525|delta/epsilon subdivisions,2WUVD@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
HKD2_k127_6142920_0	1167006.UWK_02921	1.88e-81	290.0	COG0826@1|root,COG0826@2|Bacteria,1MUQG@1224|Proteobacteria,42NTQ@68525|delta/epsilon subdivisions,2WITY@28221|Deltaproteobacteria,2MIFP@213118|Desulfobacterales	28221|Deltaproteobacteria	O	PFAM peptidase	-	-	-	ko:K08303	ko05120,map05120	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_U32
HKD2_k127_6155697_4	644281.MFS40622_0822	2.5e-38	153.0	COG1941@1|root,arCOG02472@2157|Archaea,2XVJ0@28890|Euryarchaeota,23QEJ@183939|Methanococci	183939|Methanococci	C	PFAM NADH ubiquinone oxidoreductase 20 kDa subunit	vhuG	-	1.8.98.5	ko:K14128	ko00680,map00680	-	R00019,R11943	RC00011	ko00000,ko00001,ko01000	-	-	-	Oxidored_q6
HKD2_k127_6155697_3	1041930.Mtc_0109	7.372e-73	261.0	COG0374@1|root,arCOG01549@2157|Archaea,2XTHE@28890|Euryarchaeota,2NAHJ@224756|Methanomicrobia	224756|Methanomicrobia	C	Belongs to the NiFe NiFeSe hydrogenase large subunit family	mvhA-1	-	1.8.98.5	ko:K14126	ko00680,map00680	-	R00019,R11943	RC00011	ko00000,ko00001,ko01000	-	-	-	NiFeSe_Hases
HKD2_k127_6155697_1	1232410.KI421426_gene1478	4.163e-178	562.0	COG0191@1|root,COG0191@2|Bacteria,1MURX@1224|Proteobacteria,42MK7@68525|delta/epsilon subdivisions,2WJCJ@28221|Deltaproteobacteria,43SZB@69541|Desulfuromonadales	28221|Deltaproteobacteria	G	Fructose-bisphosphate aldolase class-II	fbaA	-	4.1.2.13	ko:K01624	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167,M00344,M00345	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	F_bP_aldolase
HKD2_k127_6155697_0	1232410.KI421426_gene1356	2.501e-197	622.0	COG0205@1|root,COG0205@2|Bacteria,1MVN3@1224|Proteobacteria,42NMZ@68525|delta/epsilon subdivisions,2WIZ0@28221|Deltaproteobacteria,43T6D@69541|Desulfuromonadales	28221|Deltaproteobacteria	G	Phosphofructokinase	pfkA	-	2.7.1.11	ko:K00850	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230	M00001,M00345	R00756,R03236,R03237,R03238,R03239,R04779	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000,ko01009,ko03019	-	-	-	PFK
HKD2_k127_6155697_2	1232410.KI421426_gene1487	3.417e-103	339.0	COG0469@1|root,COG0469@2|Bacteria,1MU21@1224|Proteobacteria,42N30@68525|delta/epsilon subdivisions,2WJSW@28221|Deltaproteobacteria,43T0A@69541|Desulfuromonadales	28221|Deltaproteobacteria	G	Pyruvate kinase, barrel domain	pyk	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PK,PK_C
HKD2_k127_6165509_0	472759.Nhal_1615	1.774e-94	319.0	COG2864@1|root,COG2864@2|Bacteria,1MXFQ@1224|Proteobacteria,1RP1B@1236|Gammaproteobacteria,1WZVK@135613|Chromatiales	135613|Chromatiales	C	Prokaryotic cytochrome b561	-	-	-	ko:K00127	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001	-	-	-	Ni_hydr_CYTB
HKD2_k127_6165509_1	338963.Pcar_2366	3.979e-14	85.0	COG2199@1|root,COG2984@1|root,COG4191@1|root,COG2199@2|Bacteria,COG2984@2|Bacteria,COG4191@2|Bacteria,1R609@1224|Proteobacteria,42MTJ@68525|delta/epsilon subdivisions,2WJYM@28221|Deltaproteobacteria,43UB8@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GAF,GAF_2,HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Pkinase
HKD2_k127_6200437_2	1121403.AUCV01000005_gene334	1.118e-50	182.0	COG4520@1|root,COG4520@2|Bacteria,1N0YF@1224|Proteobacteria,42W7B@68525|delta/epsilon subdivisions,2WS2B@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Glycine zipper 2TM domain	-	-	-	-	-	-	-	-	-	-	-	-	Gly-zipper_Omp
HKD2_k127_6200437_3	1121403.AUCV01000005_gene333	2.613e-48	181.0	COG0432@1|root,COG0432@2|Bacteria,1RH13@1224|Proteobacteria,42TJK@68525|delta/epsilon subdivisions,2WQ0Z@28221|Deltaproteobacteria,2MK0F@213118|Desulfobacterales	28221|Deltaproteobacteria	S	TIGRFAM secondary thiamine-phosphate synthase enzyme	-	-	-	-	-	-	-	-	-	-	-	-	UPF0047
HKD2_k127_6200437_4	1121403.AUCV01000005_gene332	1.479e-14	78.0	2EBS7@1|root,335S2@2|Bacteria,1NBWR@1224|Proteobacteria,42WCA@68525|delta/epsilon subdivisions,2WRUH@28221|Deltaproteobacteria,2MKKJ@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6200437_0	1121403.AUCV01000005_gene331	4.157e-306	945.0	COG0043@1|root,COG0043@2|Bacteria,1MU62@1224|Proteobacteria,42MGF@68525|delta/epsilon subdivisions,2WJMB@28221|Deltaproteobacteria,2MIRI@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Belongs to the UbiD family	-	-	4.1.1.98	ko:K03182	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04985,R04986	RC00391	ko00000,ko00001,ko00002,ko01000	-	-	-	UbiD
HKD2_k127_6200437_1	1121403.AUCV01000005_gene330	1.016e-90	316.0	COG1187@1|root,COG1187@2|Bacteria,1MUCE@1224|Proteobacteria,42NI7@68525|delta/epsilon subdivisions,2WNPX@28221|Deltaproteobacteria,2MJIB@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Belongs to the pseudouridine synthase RsuA family	rluB	-	5.4.99.21,5.4.99.22	ko:K06178,ko:K06182	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
HKD2_k127_620716_12	96561.Dole_0216	1.114e-11	69.0	COG2920@1|root,COG2920@2|Bacteria,1NPP9@1224|Proteobacteria,42XRZ@68525|delta/epsilon subdivisions,2WT1P@28221|Deltaproteobacteria,2MPQI@213118|Desulfobacterales	28221|Deltaproteobacteria	P	part of a sulfur-relay system	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_620716_2	690850.Desaf_1337	1.092e-111	381.0	COG0842@1|root,COG0842@2|Bacteria,1N55T@1224|Proteobacteria,42N8F@68525|delta/epsilon subdivisions,2WK3B@28221|Deltaproteobacteria,2MA60@213115|Desulfovibrionales	28221|Deltaproteobacteria	V	PFAM ABC-2 type transporter	-	-	-	ko:K09694	ko02010,map02010	M00252	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.102	-	-	ABC2_membrane
HKD2_k127_620716_1	690850.Desaf_1338	5.057e-119	390.0	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,42MV1@68525|delta/epsilon subdivisions,2WM7T@28221|Deltaproteobacteria,2M8AB@213115|Desulfovibrionales	28221|Deltaproteobacteria	V	pfam abc	-	-	-	ko:K01990,ko:K09695	ko02010,map02010	M00252,M00254	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.102	-	-	ABC_tran,DUF4162
HKD2_k127_620716_13	1463857.JOFZ01000015_gene764	2.609e-09	68.0	COG3209@1|root,COG3209@2|Bacteria,2GMBB@201174|Actinobacteria	201174|Actinobacteria	M	COG3209 Rhs family protein	-	-	-	-	-	-	-	-	-	-	-	-	PT-HINT,RHS_repeat,TGFb_propeptide,Tox-REase-5
HKD2_k127_620716_6	373994.Riv7116_1000	7.491e-36	140.0	COG1047@1|root,COG1047@2|Bacteria,1G5R4@1117|Cyanobacteria,1HSF7@1161|Nostocales	1117|Cyanobacteria	O	FKBP-type peptidyl-prolyl cis-trans isomerase	-	-	5.2.1.8	ko:K01802	-	-	-	-	ko00000,ko01000	-	-	-	FKBP_C
HKD2_k127_620716_8	56780.SYN_03642	2.564e-33	131.0	COG1225@1|root,COG1225@2|Bacteria,1P69S@1224|Proteobacteria,432W3@68525|delta/epsilon subdivisions,2WXMP@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	AhpC/TSA family	-	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
HKD2_k127_620716_14	994479.GL877878_gene2620	0.0001847	45.0	COG1225@1|root,COG1225@2|Bacteria,2GKME@201174|Actinobacteria,4E2X5@85010|Pseudonocardiales	201174|Actinobacteria	O	PFAM AhpC TSA family	ahpE	GO:0003674,GO:0003824,GO:0004601,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0008150,GO:0008152,GO:0009605,GO:0009607,GO:0009636,GO:0009987,GO:0016209,GO:0016491,GO:0016684,GO:0020012,GO:0030682,GO:0042221,GO:0043207,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051409,GO:0051701,GO:0051704,GO:0051707,GO:0051716,GO:0051805,GO:0051807,GO:0051832,GO:0051834,GO:0051920,GO:0052060,GO:0052173,GO:0052200,GO:0052376,GO:0052551,GO:0052564,GO:0052565,GO:0052572,GO:0055114,GO:0070887,GO:0075136,GO:0097237,GO:0098754,GO:0098869,GO:1990748	1.11.1.15	ko:K03386	ko04214,map04214	-	-	-	ko00000,ko00001,ko01000,ko04147	-	-	-	AhpC-TSA
HKD2_k127_620716_3	1167006.UWK_02625	5.21e-93	313.0	COG1456@1|root,COG1456@2|Bacteria,1R9BV@1224|Proteobacteria,42P65@68525|delta/epsilon subdivisions,2WMGX@28221|Deltaproteobacteria,2MI6I@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM Fe-S cluster domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF3786,FeS
HKD2_k127_620716_4	1167006.UWK_00604	3.436e-79	270.0	COG2129@1|root,COG2129@2|Bacteria,1RFU9@1224|Proteobacteria	1224|Proteobacteria	S	phosphoesterases, related to the Icc protein	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos,Metallophos_2
HKD2_k127_620716_0	177439.DP2415	2.891e-156	505.0	COG0006@1|root,COG0006@2|Bacteria,1N763@1224|Proteobacteria,42PVQ@68525|delta/epsilon subdivisions,2WK4N@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	PFAM peptidase M24	-	-	3.4.11.9,3.4.13.9	ko:K01262,ko:K01271	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Peptidase_M24
HKD2_k127_620716_5	1397284.AYMN01000030_gene3594	2.734e-57	203.0	COG1671@1|root,COG1671@2|Bacteria,1RCZA@1224|Proteobacteria,1S3QM@1236|Gammaproteobacteria,401EV@613|Serratia	1236|Gammaproteobacteria	S	Belongs to the UPF0178 family	yaiI	-	-	ko:K09768	-	-	-	-	ko00000	-	-	-	DUF188
HKD2_k127_620716_11	1124780.ANNU01000054_gene3509	1.5e-22	98.0	COG4895@1|root,COG4895@2|Bacteria,4NUT0@976|Bacteroidetes,47RYA@768503|Cytophagia	976|Bacteroidetes	S	Uncharacterized conserved protein (DUF2196)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2196
HKD2_k127_620716_7	521045.Kole_1745	1.281e-34	137.0	COG1047@1|root,COG1047@2|Bacteria,2GD8F@200918|Thermotogae	200918|Thermotogae	G	peptidyl-prolyl cis-trans isomerase	-	-	-	-	-	-	-	-	-	-	-	-	FKBP_C
HKD2_k127_620716_9	1304885.AUEY01000003_gene442	1.812e-26	118.0	COG1413@1|root,COG1413@2|Bacteria,1Q4WF@1224|Proteobacteria,4300V@68525|delta/epsilon subdivisions,2WV99@28221|Deltaproteobacteria,2MNIP@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Protein of unknown function (DUF1186)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1186
HKD2_k127_6223090_1	1167006.UWK_00353	4.965e-126	418.0	COG3127@1|root,COG3127@2|Bacteria,1MU9R@1224|Proteobacteria,42N9P@68525|delta/epsilon subdivisions,2WJ0G@28221|Deltaproteobacteria,2MJ0M@213118|Desulfobacterales	28221|Deltaproteobacteria	Q	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HKD2_k127_6223090_5	1167006.UWK_00354	5.761e-94	313.0	COG1136@1|root,COG1136@2|Bacteria,1QU8Q@1224|Proteobacteria,42S10@68525|delta/epsilon subdivisions,2WNEX@28221|Deltaproteobacteria,2MPTQ@213118|Desulfobacterales	28221|Deltaproteobacteria	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD2_k127_6223090_7	768670.Calni_0443	4.956e-67	246.0	COG0490@1|root,COG1226@1|root,COG0490@2|Bacteria,COG1226@2|Bacteria,2GENC@200930|Deferribacteres	200930|Deferribacteres	P	Ion channel	-	-	-	ko:K10716	-	-	-	-	ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	Ion_trans_2,TrkA_C,TrkA_N
HKD2_k127_6223090_4	1286093.C266_14977	4.233e-96	336.0	COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2VIZN@28216|Betaproteobacteria,1K1TM@119060|Burkholderiaceae	28216|Betaproteobacteria	NT	chemotaxis	wspA	-	-	ko:K13487	ko02020,ko02025,map02020,map02025	-	-	-	ko00000,ko00001	-	-	-	4HB_MCP_1,CHASE3,HAMP,MCPsignal
HKD2_k127_6223090_11	1122604.JONR01000003_gene1379	1.079e-30	126.0	COG0835@1|root,COG0835@2|Bacteria,1N0R3@1224|Proteobacteria,1SG9X@1236|Gammaproteobacteria,1X945@135614|Xanthomonadales	135614|Xanthomonadales	NT	Two component signalling adaptor domain	-	-	-	ko:K13488	ko02020,ko02025,map02020,map02025	-	-	-	ko00000,ko00001	-	-	-	CheW
HKD2_k127_6223090_6	685778.AORL01000010_gene2700	6.038e-83	291.0	COG1352@1|root,COG1352@2|Bacteria,1MVP3@1224|Proteobacteria,2U4ES@28211|Alphaproteobacteria	28211|Alphaproteobacteria	NT	Methyltransferase, chemotaxis proteins	-	-	2.1.1.80	ko:K00575,ko:K13486	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko01000,ko02035	-	-	-	CheR
HKD2_k127_6223090_9	1500894.JQNN01000001_gene439	4.936e-35	143.0	COG0835@1|root,COG0835@2|Bacteria,1RIUD@1224|Proteobacteria,2VSFU@28216|Betaproteobacteria,474PD@75682|Oxalobacteraceae	28216|Betaproteobacteria	NT	Two component signalling adaptor domain	wspD	-	-	ko:K13489	ko02020,ko02025,map02020,map02025	-	-	-	ko00000,ko00001	-	-	-	CheW
HKD2_k127_6223090_0	886293.Sinac_4831	4.435e-243	784.0	COG0643@1|root,COG0745@1|root,COG2198@1|root,COG0643@2|Bacteria,COG0745@2|Bacteria,COG2198@2|Bacteria,2IYFY@203682|Planctomycetes	203682|Planctomycetes	T	RESPONSE REGULATOR receiver	-	-	-	ko:K13490	ko02020,ko02025,map02020,map02025	M00509	-	-	ko00000,ko00001,ko00002,ko01001,ko02022	-	-	-	CheW,HATPase_c,Hpt,Response_reg
HKD2_k127_6223090_3	391038.Bphy_5390	2.564e-100	338.0	COG2201@1|root,COG2201@2|Bacteria,1QBTV@1224|Proteobacteria,2VPFD@28216|Betaproteobacteria,1K2NP@119060|Burkholderiaceae	28216|Betaproteobacteria	NT	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR	-	-	3.1.1.61	ko:K13491	ko02020,ko02025,map02020,map02025	M00509	-	-	ko00000,ko00001,ko00002,ko01000,ko02022	-	-	-	CheB_methylest,Response_reg
HKD2_k127_6223090_2	686578.AFFX01000002_gene713	3.394e-111	369.0	COG2199@1|root,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,1S1A7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain	wspR	-	2.7.7.65,3.1.3.3	ko:K07315,ko:K11444	ko02020,ko02025,map02020,map02025	M00509	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko03021	-	-	-	GGDEF,Response_reg
HKD2_k127_6223090_10	1121403.AUCV01000002_gene486	5.154e-33	128.0	COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,42V0K@68525|delta/epsilon subdivisions,2WR92@28221|Deltaproteobacteria,2MKYU@213118|Desulfobacterales	28221|Deltaproteobacteria	K	PFAM Cold-shock	-	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
HKD2_k127_6223090_8	1121403.AUCV01000006_gene402	1.56e-39	156.0	COG3807@1|root,COG3807@2|Bacteria,1QW18@1224|Proteobacteria,43BR9@68525|delta/epsilon subdivisions,2X726@28221|Deltaproteobacteria,2MPJ1@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Bacterial SH3 domain homologues	-	-	-	ko:K07184	-	-	-	-	ko00000	-	-	-	SH3_3
HKD2_k127_6238655_0	589865.DaAHT2_1165	2.145e-117	386.0	COG1995@1|root,COG1995@2|Bacteria,1MX5W@1224|Proteobacteria,42NJJ@68525|delta/epsilon subdivisions,2WJGI@28221|Deltaproteobacteria,2MHYF@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)	pdxA	-	1.1.1.262,1.1.1.408,1.1.1.409	ko:K00097,ko:K22024	ko00750,ko01100,map00750,map01100	M00124	R05681,R05837,R07406	RC00089,RC00675,RC01475	ko00000,ko00001,ko00002,ko01000	-	-	-	PdxA
HKD2_k127_6238655_6	589865.DaAHT2_1166	2.675e-26	115.0	COG0792@1|root,COG0792@2|Bacteria,1N6VN@1224|Proteobacteria,42VES@68525|delta/epsilon subdivisions,2WRSC@28221|Deltaproteobacteria,2MM4E@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Belongs to the UPF0102 family	-	-	-	ko:K07460	-	-	-	-	ko00000	-	-	-	UPF0102
HKD2_k127_6238655_2	1121403.AUCV01000008_gene1643	3.537e-67	236.0	COG0164@1|root,COG0164@2|Bacteria,1RA65@1224|Proteobacteria,42REG@68525|delta/epsilon subdivisions,2WNK2@28221|Deltaproteobacteria,2MJIK@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhB	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576	3.1.26.4	ko:K03470	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DUF208,RNase_HII
HKD2_k127_6238655_4	1121403.AUCV01000008_gene1642	6.926e-56	198.0	COG0335@1|root,COG0335@2|Bacteria,1RH3A@1224|Proteobacteria,42TMU@68525|delta/epsilon subdivisions,2WQ67@28221|Deltaproteobacteria,2MK6N@213118|Desulfobacterales	28221|Deltaproteobacteria	J	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site	rplS	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02884	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L19
HKD2_k127_6238655_3	1121403.AUCV01000008_gene1641	2.987e-65	229.0	COG4752@1|root,COG4752@2|Bacteria,1RJ2G@1224|Proteobacteria,42SXX@68525|delta/epsilon subdivisions,2WP1I@28221|Deltaproteobacteria,2MJZA@213118|Desulfobacterales	28221|Deltaproteobacteria	S	SAM-dependent RNA methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltrn_RNA_4
HKD2_k127_6238655_1	1167006.UWK_03356	7.607e-95	321.0	COG0336@1|root,COG0336@2|Bacteria,1MUN1@1224|Proteobacteria,42P8R@68525|delta/epsilon subdivisions,2WKIR@28221|Deltaproteobacteria,2MIUI@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Belongs to the RNA methyltransferase TrmD family	trmD	GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050518,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.1.1.228	ko:K00554	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	Methyltrn_RNA_4,tRNA_m1G_MT
HKD2_k127_6238655_5	1121403.AUCV01000008_gene1639	1.1e-33	138.0	COG0806@1|root,COG0806@2|Bacteria,1MWQR@1224|Proteobacteria,42TGI@68525|delta/epsilon subdivisions,2WQJU@28221|Deltaproteobacteria,2MKM1@213118|Desulfobacterales	28221|Deltaproteobacteria	J	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes	rimM	-	-	ko:K02860	-	-	-	-	ko00000,ko03009	-	-	-	PRC,RimM
HKD2_k127_6238655_7	1121403.AUCV01000008_gene1638	1.237e-15	77.0	COG1837@1|root,COG1837@2|Bacteria,1N7IX@1224|Proteobacteria,42TXI@68525|delta/epsilon subdivisions,2WQBS@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Belongs to the UPF0109 family	-	-	-	ko:K06960	-	-	-	-	ko00000	-	-	-	KH_4
HKD2_k127_6250455_1	1167006.UWK_02461	6.772e-68	234.0	COG1216@1|root,COG1216@2|Bacteria,1QX2S@1224|Proteobacteria,43BW7@68525|delta/epsilon subdivisions,2X76X@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HKD2_k127_6250455_0	1167006.UWK_02462	2.92e-287	903.0	COG5610@1|root,COG5610@2|Bacteria,1Q4T5@1224|Proteobacteria,42V28@68525|delta/epsilon subdivisions,2WQSC@28221|Deltaproteobacteria,2MN8X@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6250455_2	1167006.UWK_02465	1.704e-12	75.0	COG1835@1|root,COG1835@2|Bacteria	2|Bacteria	I	transferase activity, transferring acyl groups other than amino-acyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
HKD2_k127_6256916_6	589865.DaAHT2_0948	4.45e-55	196.0	COG1661@1|root,COG1661@2|Bacteria,1RIUJ@1224|Proteobacteria,42SC0@68525|delta/epsilon subdivisions,2WPPG@28221|Deltaproteobacteria,2MKD3@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF296)	-	-	-	-	-	-	-	-	-	-	-	-	DUF296
HKD2_k127_6256916_8	1121403.AUCV01000039_gene4361	6.347e-40	155.0	COG3028@1|root,COG3028@2|Bacteria,1Q2IU@1224|Proteobacteria,42VT6@68525|delta/epsilon subdivisions,2WRIU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Protein of unknown function (DUF615)	-	-	-	ko:K09889	-	-	-	-	ko00000,ko03009	-	-	-	DUF615
HKD2_k127_6256916_1	1167006.UWK_03274	2.736e-173	551.0	COG1454@1|root,COG1454@2|Bacteria,1MVPH@1224|Proteobacteria,42MBY@68525|delta/epsilon subdivisions,2WIR5@28221|Deltaproteobacteria,2MISX@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM Iron-containing alcohol dehydrogenase	-	-	1.1.1.1	ko:K00001,ko:K19954	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	Fe-ADH
HKD2_k127_6256916_2	1121472.AQWN01000003_gene1427	4.066e-115	384.0	COG0452@1|root,COG0452@2|Bacteria,1TPP3@1239|Firmicutes,247J3@186801|Clostridia,25ZXR@186807|Peptococcaceae	186801|Clostridia	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	coaBC	-	4.1.1.36,6.3.2.5	ko:K01598,ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	DFP,Flavoprotein
HKD2_k127_6256916_5	589865.DaAHT2_0557	6.826e-63	221.0	COG0778@1|root,COG0778@2|Bacteria,1RECN@1224|Proteobacteria,42SPP@68525|delta/epsilon subdivisions,2WPPZ@28221|Deltaproteobacteria,2MMK2@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
HKD2_k127_6256916_3	589865.DaAHT2_0558	1.85e-88	300.0	COG0084@1|root,COG0084@2|Bacteria,1MUC0@1224|Proteobacteria,42MMS@68525|delta/epsilon subdivisions,2WMUI@28221|Deltaproteobacteria,2MIBY@213118|Desulfobacterales	28221|Deltaproteobacteria	L	TIGRFAM hydrolase, TatD family	tatD	-	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	Fer4_14,Radical_SAM,TatD_DNase
HKD2_k127_6256916_4	1121403.AUCV01000039_gene4357	4.289e-69	244.0	COG0325@1|root,COG0325@2|Bacteria,1MWN7@1224|Proteobacteria,42PSG@68525|delta/epsilon subdivisions,2WKYN@28221|Deltaproteobacteria,2MJ9P@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis	yggS	-	-	ko:K06997	-	-	-	-	ko00000	-	-	-	Ala_racemase_N
HKD2_k127_6256916_0	1121403.AUCV01000039_gene4356	1.506e-220	694.0	COG1004@1|root,COG1004@2|Bacteria,1MW5U@1224|Proteobacteria,42MDV@68525|delta/epsilon subdivisions,2WJ3T@28221|Deltaproteobacteria,2MHMX@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	ugd	-	1.1.1.22	ko:K00012	ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100	M00014,M00129,M00361,M00362	R00286	RC00291	ko00000,ko00001,ko00002,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
HKD2_k127_6256916_9	1121403.AUCV01000039_gene4355	1.097e-29	121.0	2E79S@1|root,331TB@2|Bacteria,1NABI@1224|Proteobacteria,42V7R@68525|delta/epsilon subdivisions,2WRM1@28221|Deltaproteobacteria,2MKFF@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6371917_3	366394.Smed_5067	3.44e-20	92.0	COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,2TR1D@28211|Alphaproteobacteria,4BE6T@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
HKD2_k127_6371917_0	1116369.KB890024_gene231	9.951e-122	397.0	COG0601@1|root,COG0601@2|Bacteria,1MW3U@1224|Proteobacteria,2TUR2@28211|Alphaproteobacteria,43P07@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	EP	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
HKD2_k127_6371917_1	1116369.KB890024_gene230	4.23e-119	392.0	COG1173@1|root,COG1173@2|Bacteria,1MXGS@1224|Proteobacteria,2TTQ7@28211|Alphaproteobacteria,43NEV@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	EP	N-terminal TM domain of oligopeptide transport permease C	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
HKD2_k127_6371917_2	1116369.KB890024_gene229	1.033e-50	184.0	COG0444@1|root,COG0444@2|Bacteria,1R4KB@1224|Proteobacteria,2TR0J@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031,ko:K15583	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
HKD2_k127_6384817_2	1121403.AUCV01000012_gene4020	7.077e-94	310.0	COG0407@1|root,COG0407@2|Bacteria,1MUG1@1224|Proteobacteria,42MV9@68525|delta/epsilon subdivisions,2WJZK@28221|Deltaproteobacteria,2MP6C@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	hemE	GO:0003674,GO:0003824,GO:0004853,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_0016	URO-D
HKD2_k127_6384817_5	1167006.UWK_00076	5.994e-46	178.0	COG2844@1|root,COG2844@2|Bacteria	2|Bacteria	O	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen	glnD	-	1.1.1.3,1.4.1.2,2.7.7.42,2.7.7.59,2.7.7.89	ko:K00003,ko:K00982,ko:K00990,ko:K06950,ko:K15371	ko00220,ko00250,ko00260,ko00270,ko00300,ko00430,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,ko02020,map00220,map00250,map00260,map00270,map00300,map00430,map00910,map01100,map01110,map01120,map01130,map01230,map02020	M00017,M00018	R00243,R01773,R01775	RC00006,RC00087,RC02799	ko00000,ko00001,ko00002,ko01000	-	-	-	AAA_33,ACT,DUF294,GlnD_UR_UTase,HD,NTP_transf_2
HKD2_k127_6384817_4	335543.Sfum_1656	7.742e-56	213.0	COG1234@1|root,COG1234@2|Bacteria,1PE64@1224|Proteobacteria,42RZR@68525|delta/epsilon subdivisions,2WNPZ@28221|Deltaproteobacteria,2MS6E@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
HKD2_k127_6384817_3	767817.Desgi_2411	8.355e-82	284.0	COG0491@1|root,COG0491@2|Bacteria,1V2XF@1239|Firmicutes,24JW4@186801|Clostridia	186801|Clostridia	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HKD2_k127_6384817_0	1121403.AUCV01000012_gene4017	3.7e-207	657.0	COG1236@1|root,COG1236@2|Bacteria,1MUDD@1224|Proteobacteria,42N91@68525|delta/epsilon subdivisions,2WIMM@28221|Deltaproteobacteria,2MIKE@213118|Desulfobacterales	28221|Deltaproteobacteria	J	RNA-metabolising metallo-beta-lactamase	-	-	-	ko:K07576	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B,Lactamase_B_6,RMMBL
HKD2_k127_6384817_1	643562.Daes_2034	6.732e-142	458.0	COG1032@1|root,COG1032@2|Bacteria,1MY2Y@1224|Proteobacteria,42NG3@68525|delta/epsilon subdivisions,2WJ95@28221|Deltaproteobacteria,2M84C@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,DUF4070,Radical_SAM
HKD2_k127_6394425_0	65393.PCC7424_1253	9.66e-107	367.0	COG1215@1|root,COG1216@1|root,COG1215@2|Bacteria,COG1216@2|Bacteria,1GQBE@1117|Cyanobacteria,3KGYF@43988|Cyanothece	1117|Cyanobacteria	M	PFAM glycosyl transferase family 2	-	-	-	ko:K20444	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.1.3	GT2,GT4	-	Glycos_transf_2
HKD2_k127_6394425_1	1121937.AUHJ01000011_gene2945	3.565e-100	338.0	COG0500@1|root,COG2226@2|Bacteria,1QYPC@1224|Proteobacteria,1SHPN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6404755_2	1131269.AQVV01000020_gene2195	2.311e-21	93.0	COG1173@1|root,COG1173@2|Bacteria	2|Bacteria	P	ABC-type dipeptide oligopeptide nickel transport systems, permease components	appC	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
HKD2_k127_6404755_0	867903.ThesuDRAFT_02282	1.218e-107	361.0	COG0444@1|root,COG0444@2|Bacteria,1TP6E@1239|Firmicutes,247NN@186801|Clostridia	186801|Clostridia	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031,ko:K15583	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
HKD2_k127_6404755_1	644966.Tmar_0296	2.259e-57	204.0	COG4608@1|root,COG4608@2|Bacteria,1V36J@1239|Firmicutes,24C3R@186801|Clostridia	186801|Clostridia	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02032,ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
HKD2_k127_6407668_6	237368.SCABRO_02097	5.975e-07	53.0	COG0748@1|root,COG0748@2|Bacteria	2|Bacteria	P	coenzyme F420 binding	-	-	1.4.3.5	ko:K00275	ko00750,ko01100,ko01120,map00750,map01100,map01120	M00124	R00277,R00278,R01710,R01711	RC00048,RC00116	ko00000,ko00001,ko00002,ko01000	-	-	-	Putative_PNPOx
HKD2_k127_6407668_1	589865.DaAHT2_2622	5.015e-212	671.0	COG0702@1|root,COG0702@2|Bacteria,1PDTN@1224|Proteobacteria,42M8X@68525|delta/epsilon subdivisions,2WJ5J@28221|Deltaproteobacteria,2MHQP@213118|Desulfobacterales	28221|Deltaproteobacteria	GM	Protein of unknown function (DUF2867)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2867,NAD_binding_10
HKD2_k127_6407668_5	1158165.KB898872_gene1099	8.116e-12	70.0	COG2044@1|root,COG2044@2|Bacteria,1N4KA@1224|Proteobacteria,1SC3W@1236|Gammaproteobacteria,1X1EH@135613|Chromatiales	135613|Chromatiales	S	DsrE/DsrF-like family	-	-	-	-	-	-	-	-	-	-	-	-	DrsE
HKD2_k127_6407668_4	518766.Rmar_2453	7.069e-28	119.0	COG0789@1|root,COG0789@2|Bacteria,4NW77@976|Bacteroidetes,1FK6E@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	K	MerR, DNA binding	-	-	-	ko:K19591	-	M00769	-	-	ko00000,ko00002,ko01504,ko03000	-	-	-	MerR_1
HKD2_k127_6407668_0	1121918.ARWE01000001_gene3296	0.0	1020.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,42M2R@68525|delta/epsilon subdivisions,2WJ4J@28221|Deltaproteobacteria,43S35@69541|Desulfuromonadales	28221|Deltaproteobacteria	P	E1-E2 ATPase	copF	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase,YHS
HKD2_k127_6407668_2	1121396.KB893001_gene3951	9.612e-115	384.0	COG2067@1|root,COG2067@2|Bacteria,1NHG3@1224|Proteobacteria	1224|Proteobacteria	I	Outer membrane protein transport protein (OMPP1/FadL/TodX)	-	-	-	ko:K06076	-	-	-	-	ko00000,ko02000	1.B.9	-	-	Toluene_X
HKD2_k127_6407668_3	880073.Calab_3761	4.739e-37	153.0	COG1462@1|root,COG1462@2|Bacteria,2NQ4P@2323|unclassified Bacteria	2|Bacteria	M	Curli production assembly transport component CsgG	csgG	-	-	-	-	-	-	-	-	-	-	-	CsgG,DUF4384,FlgT_C,PG_binding_1
HKD2_k127_6424785_2	1167006.UWK_02829	1.834e-54	193.0	COG4166@1|root,COG4166@2|Bacteria,1MUVU@1224|Proteobacteria,42PKT@68525|delta/epsilon subdivisions,2WK85@28221|Deltaproteobacteria,2MPTE@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K13893	ko02010,map02010	M00349	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.21,3.A.1.5.24	-	-	SBP_bac_5
HKD2_k127_6424785_3	1167006.UWK_02831	6.32e-40	154.0	COG0802@1|root,COG0802@2|Bacteria,1RGYU@1224|Proteobacteria,42VU4@68525|delta/epsilon subdivisions,2WQBA@28221|Deltaproteobacteria,2MKGC@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Threonylcarbamoyl adenosine biosynthesis protein TsaE	yjeE	-	-	ko:K06925	-	-	-	-	ko00000,ko03016	-	-	-	TsaE
HKD2_k127_6424785_0	1121403.AUCV01000002_gene589	1.129e-249	782.0	COG0457@1|root,COG1944@1|root,COG0457@2|Bacteria,COG1944@2|Bacteria,1MV7K@1224|Proteobacteria,42N4B@68525|delta/epsilon subdivisions,2WJ34@28221|Deltaproteobacteria,2MHRU@213118|Desulfobacterales	28221|Deltaproteobacteria	S	YcaO cyclodehydratase, ATP-ad Mg2+-binding	-	-	-	ko:K09136	-	-	-	-	ko00000,ko03009	-	-	-	TPR_1,TPR_16,TPR_2,TPR_8,YcaO
HKD2_k127_6424785_1	1121403.AUCV01000002_gene588	3.894e-121	400.0	COG0859@1|root,COG0859@2|Bacteria,1MXA2@1224|Proteobacteria,42NEW@68525|delta/epsilon subdivisions,2WJNJ@28221|Deltaproteobacteria,2MIGM@213118|Desulfobacterales	28221|Deltaproteobacteria	M	TIGRFAM lipopolysaccharide heptosyltransferase II	-	-	-	ko:K02843	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9
HKD2_k127_6443955_3	1121403.AUCV01000032_gene2894	2.495e-54	196.0	COG3481@1|root,COG3481@2|Bacteria,1NH0C@1224|Proteobacteria,42Q7X@68525|delta/epsilon subdivisions,2WJW2@28221|Deltaproteobacteria,2MICY@213118|Desulfobacterales	28221|Deltaproteobacteria	S	nucleic acid binding OB-fold tRNA helicase-type	yhaM	-	-	ko:K03698	-	-	-	-	ko00000,ko01000,ko03019	-	-	-	HD,tRNA_anti-codon
HKD2_k127_6443955_0	1121403.AUCV01000032_gene2893	6.567e-182	578.0	COG0012@1|root,COG0012@2|Bacteria,1MVM4@1224|Proteobacteria,42MNJ@68525|delta/epsilon subdivisions,2WIZZ@28221|Deltaproteobacteria,2MIHN@213118|Desulfobacterales	28221|Deltaproteobacteria	J	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner	ychF	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,YchF-GTPase_C
HKD2_k127_6443955_1	1121403.AUCV01000032_gene2892	4.535e-143	467.0	COG0402@1|root,COG0402@2|Bacteria,1MUFE@1224|Proteobacteria,43AI0@68525|delta/epsilon subdivisions,2X5Y7@28221|Deltaproteobacteria	28221|Deltaproteobacteria	F	Amidohydrolase family	hutF	-	3.5.3.13	ko:K05603	ko00340,map00340	-	R02286	RC00682	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
HKD2_k127_6443955_2	1121403.AUCV01000021_gene3550	1.958e-94	313.0	COG2518@1|root,COG2518@2|Bacteria,1MXQC@1224|Proteobacteria,42QSI@68525|delta/epsilon subdivisions,2WMNJ@28221|Deltaproteobacteria,2MHNG@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	pcm	-	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
HKD2_k127_6443955_4	1121403.AUCV01000021_gene3551	2.383e-34	138.0	COG2913@1|root,COG2913@2|Bacteria	2|Bacteria	J	Gram-negative-bacterium-type cell outer membrane assembly	-	-	-	-	-	-	-	-	-	-	-	-	SmpA_OmlA
HKD2_k127_6449324_5	1121403.AUCV01000002_gene632	7.101e-107	355.0	COG0042@1|root,COG0042@2|Bacteria,1MV5V@1224|Proteobacteria,42N3M@68525|delta/epsilon subdivisions,2WKM7@28221|Deltaproteobacteria,2MIXT@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines	nifR3	-	-	ko:K05540	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Dus
HKD2_k127_6449324_1	1167006.UWK_02797	1.787e-268	843.0	COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,42M80@68525|delta/epsilon subdivisions,2WINJ@28221|Deltaproteobacteria,2MPRH@213118|Desulfobacterales	28221|Deltaproteobacteria	G	Transketolase, thiamine diphosphate binding domain	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
HKD2_k127_6449324_11	1167006.UWK_02798	2.536e-48	179.0	COG2980@1|root,COG2980@2|Bacteria	2|Bacteria	M	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane	lptE	GO:0001530,GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006810,GO:0006869,GO:0008150,GO:0008289,GO:0009279,GO:0009987,GO:0010876,GO:0015920,GO:0016020,GO:0016043,GO:0019867,GO:0022607,GO:0030312,GO:0030313,GO:0031975,GO:0033036,GO:0043163,GO:0043165,GO:0044085,GO:0044091,GO:0044462,GO:0044464,GO:0045229,GO:0051179,GO:0051234,GO:0061024,GO:0071702,GO:0071709,GO:0071840,GO:0071944,GO:0097367,GO:1901264	-	ko:K03643	-	-	-	-	ko00000,ko02000	1.B.42.1	-	iECH74115_1262.ECH74115_0730,iECSP_1301.ECSP_0694,iECs_1301.ECs0679,iG2583_1286.G2583_0804,iZ_1308.Z0788	LptE
HKD2_k127_6449324_0	1121403.AUCV01000002_gene630	0.0	1250.0	COG0495@1|root,COG0495@2|Bacteria,1MV47@1224|Proteobacteria,42MRQ@68525|delta/epsilon subdivisions,2WJ3E@28221|Deltaproteobacteria,2MJ6A@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	iAF987.Gmet_2300	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
HKD2_k127_6449324_2	1121403.AUCV01000002_gene629	2.561e-208	662.0	COG0305@1|root,COG0305@2|Bacteria,1MUG9@1224|Proteobacteria,42M7X@68525|delta/epsilon subdivisions,2WJCA@28221|Deltaproteobacteria,2MHKJ@213118|Desulfobacterales	28221|Deltaproteobacteria	L	it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins	dnaB	-	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C
HKD2_k127_6449324_13	1121403.AUCV01000002_gene628	2.896e-43	163.0	COG0359@1|root,COG0359@2|Bacteria,1RD0R@1224|Proteobacteria,42SCQ@68525|delta/epsilon subdivisions,2WPZQ@28221|Deltaproteobacteria,2MJFS@213118|Desulfobacterales	28221|Deltaproteobacteria	J	binds to the 23S rRNA	rplI	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02939	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L9_C,Ribosomal_L9_N
HKD2_k127_6449324_14	177439.DP2597	2.189e-41	165.0	COG4241@1|root,COG4241@2|Bacteria,1N4XJ@1224|Proteobacteria,42QCS@68525|delta/epsilon subdivisions,2WKDT@28221|Deltaproteobacteria,2MIFQ@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Predicted membrane protein (DUF2232)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2232
HKD2_k127_6449324_16	589865.DaAHT2_1148	6.658e-27	111.0	COG0238@1|root,COG0238@2|Bacteria,1MZ8U@1224|Proteobacteria,42VJQ@68525|delta/epsilon subdivisions,2WR7Z@28221|Deltaproteobacteria,2MKM0@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit	rpsR	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02963	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S18
HKD2_k127_6449324_12	1121403.AUCV01000002_gene626	6.47e-45	166.0	COG0360@1|root,COG0360@2|Bacteria,1RH82@1224|Proteobacteria,42TJR@68525|delta/epsilon subdivisions,2WRDG@28221|Deltaproteobacteria,2MKEY@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Binds together with S18 to 16S ribosomal RNA	rpsF	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0019843,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070181,GO:0097159,GO:1901363,GO:1990904	-	ko:K02990	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S6
HKD2_k127_6449324_6	629265.PMA4326_10330	4.817e-97	330.0	COG1835@1|root,COG1835@2|Bacteria,1RICE@1224|Proteobacteria,1S7WK@1236|Gammaproteobacteria,1Z77H@136849|Pseudomonas syringae group	1236|Gammaproteobacteria	I	Exopolysaccharide production protein ExoZ	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
HKD2_k127_6449324_7	344747.PM8797T_04660	4.075e-85	287.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
HKD2_k127_6449324_8	1121405.dsmv_0900	2.097e-76	260.0	COG3945@1|root,COG3945@2|Bacteria,1N3AR@1224|Proteobacteria,42UWM@68525|delta/epsilon subdivisions,2WQEC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM Hemerythrin HHE cation binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
HKD2_k127_6449324_19	87626.PTD2_07624	1.698e-13	83.0	2DBGF@1|root,2Z94C@2|Bacteria,1R750@1224|Proteobacteria,1RZQE@1236|Gammaproteobacteria,2Q22U@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6449324_20	404589.Anae109_2051	1.262e-08	67.0	COG3055@1|root,COG4412@1|root,COG3055@2|Bacteria,COG4412@2|Bacteria,1MWWV@1224|Proteobacteria	1224|Proteobacteria	O	Zinc metalloprotease (Elastase)	-	-	-	ko:K09607	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M6
HKD2_k127_6449324_15	1121403.AUCV01000002_gene625	1.456e-34	137.0	COG1694@1|root,COG3956@2|Bacteria,1MVKM@1224|Proteobacteria,42R48@68525|delta/epsilon subdivisions,2WMAR@28221|Deltaproteobacteria,2MIAW@213118|Desulfobacterales	28221|Deltaproteobacteria	S	PFAM MazG nucleotide pyrophosphohydrolase	mazG	-	3.6.1.9	ko:K02499,ko:K04765	ko00230,ko00240,ko00760,ko00770,ko01100,map00230,map00240,map00760,map00770,map01100	-	R00086,R00087,R00103,R00287,R00426,R00515,R00662,R00720,R03004,R03036,R11323	RC00002	ko00000,ko00001,ko01000,ko03036	-	-	-	MazG
HKD2_k127_6449324_18	1121405.dsmv_3761	3.745e-22	98.0	2E496@1|root,32Z4Y@2|Bacteria,1NE0Q@1224|Proteobacteria,42VS6@68525|delta/epsilon subdivisions,2WRXJ@28221|Deltaproteobacteria,2MKUT@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6449324_10	1167006.UWK_03010	1.218e-55	201.0	COG0139@1|root,COG0139@2|Bacteria,1MW67@1224|Proteobacteria,42SGH@68525|delta/epsilon subdivisions,2WP2B@28221|Deltaproteobacteria,2MK4J@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP	hisI	-	3.5.4.19,3.6.1.31	ko:K01496,ko:K11755	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04035,R04037	RC00002,RC01055	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_1897	PRA-CH,PRA-PH
HKD2_k127_6449324_4	1121403.AUCV01000002_gene617	1.769e-152	485.0	COG0040@1|root,COG0040@2|Bacteria,1MUCY@1224|Proteobacteria,42N9N@68525|delta/epsilon subdivisions,2WIY9@28221|Deltaproteobacteria,2MHVV@213118|Desulfobacterales	28221|Deltaproteobacteria	E	ATP phosphoribosyltransferase	hisG	GO:0000105,GO:0003674,GO:0003824,GO:0003879,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.4.2.17	ko:K00765	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002,ko01000	-	-	-	HisG,HisG_C
HKD2_k127_6449324_9	1121403.AUCV01000002_gene616	1.178e-64	231.0	COG0218@1|root,COG0218@2|Bacteria,1MY3Z@1224|Proteobacteria,42RJR@68525|delta/epsilon subdivisions,2WMK3@28221|Deltaproteobacteria,2MJT8@213118|Desulfobacterales	28221|Deltaproteobacteria	D	Necessary for normal cell division and for the maintenance of normal septation	engB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K03978	-	-	-	-	ko00000,ko03036	-	-	-	MMR_HSR1
HKD2_k127_6449324_3	1121403.AUCV01000002_gene615	2.07e-192	603.0	COG0481@1|root,COG0481@2|Bacteria,1MVZA@1224|Proteobacteria,42M3D@68525|delta/epsilon subdivisions,2WJEA@28221|Deltaproteobacteria,2MI7F@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner	lepA	-	-	ko:K03596	ko05134,map05134	-	-	-	ko00000,ko00001	-	-	-	EFG_C,EFG_II,GTP_EFTU,GTP_EFTU_D2,LepA_C
HKD2_k127_6473713_2	1167006.UWK_00225	3.426e-85	292.0	COG2821@1|root,COG2821@2|Bacteria,1MXD4@1224|Proteobacteria,42P7C@68525|delta/epsilon subdivisions,2WKKF@28221|Deltaproteobacteria,2MIJE@213118|Desulfobacterales	28221|Deltaproteobacteria	M	PFAM MltA	-	-	-	ko:K08304	-	-	-	-	ko00000,ko01000,ko01011	-	GH102	-	3D,MltA
HKD2_k127_6473713_4	1167006.UWK_00226	7.179e-52	192.0	COG0500@1|root,COG2226@2|Bacteria,1RFJD@1224|Proteobacteria,42S09@68525|delta/epsilon subdivisions,2WPB6@28221|Deltaproteobacteria	28221|Deltaproteobacteria	Q	Methylase involved in ubiquinone menaquinone biosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Nitro_FeMo-Co
HKD2_k127_6473713_3	880072.Desac_0040	3.122e-52	202.0	COG1912@1|root,COG1912@2|Bacteria,1MV99@1224|Proteobacteria,42SHG@68525|delta/epsilon subdivisions,2WP1D@28221|Deltaproteobacteria,2MQGS@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	S-adenosyl-l-methionine hydroxide adenosyltransferase	-	-	-	ko:K22205	-	-	-	-	ko00000,ko01000	-	-	-	SAM_adeno_trans
HKD2_k127_6473713_6	926560.KE387023_gene1640	8.792e-21	106.0	COG4932@1|root,COG4932@2|Bacteria	2|Bacteria	M	domain protein	-	-	-	ko:K12516	-	-	-	-	ko00000,ko02000,ko02044	1.B.12.5.5	-	-	SdrD_B
HKD2_k127_6473713_7	1192034.CAP_3089	5.064e-14	84.0	COG0402@1|root,COG2374@1|root,COG0402@2|Bacteria,COG2374@2|Bacteria,1NFUA@1224|Proteobacteria,433MB@68525|delta/epsilon subdivisions,2WXJF@28221|Deltaproteobacteria,2YUGP@29|Myxococcales	28221|Deltaproteobacteria	F	Lamin Tail Domain	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1,DUF4215,LTD,TSP_3
HKD2_k127_6473713_8	446469.Sked_09240	0.0004258	52.0	COG1361@1|root,COG1361@2|Bacteria,2I3N5@201174|Actinobacteria	201174|Actinobacteria	M	Domain of unknown function DUF11	-	-	-	-	-	-	-	-	-	-	-	-	DUF11
HKD2_k127_6473713_0	1121403.AUCV01000004_gene2031	2.644e-207	651.0	COG0128@1|root,COG0128@2|Bacteria,1MWMK@1224|Proteobacteria,42N01@68525|delta/epsilon subdivisions,2WKJQ@28221|Deltaproteobacteria,2MI6K@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	-	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	EPSP_synthase
HKD2_k127_6473713_1	589865.DaAHT2_0009	1.111e-94	321.0	COG0169@1|root,COG0169@2|Bacteria,1MVH4@1224|Proteobacteria,42N54@68525|delta/epsilon subdivisions,2WMGU@28221|Deltaproteobacteria,2MI8K@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)	aroE	-	1.1.1.25	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413	RC00206	ko00000,ko00001,ko00002,ko01000	-	-	-	Shikimate_DH,Shikimate_dh_N
HKD2_k127_6473713_5	886293.Sinac_6785	6.194e-21	94.0	COG0157@1|root,COG0157@2|Bacteria,2IYVV@203682|Planctomycetes	203682|Planctomycetes	H	Belongs to the NadC ModD family	nadC	-	2.4.2.19	ko:K00767	ko00760,ko01100,map00760,map01100	M00115	R03348	RC02877	ko00000,ko00001,ko00002,ko01000	-	-	-	QRPTase_C,QRPTase_N
HKD2_k127_6517867_2	1121403.AUCV01000001_gene745	7.704e-72	249.0	COG0664@1|root,COG0664@2|Bacteria	2|Bacteria	T	cyclic nucleotide binding	-	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	TPR_6,cNMP_binding
HKD2_k127_6517867_4	1121920.AUAU01000004_gene839	1.303e-46	174.0	COG0590@1|root,COG0590@2|Bacteria,3Y4ZN@57723|Acidobacteria	57723|Acidobacteria	FJ	PFAM CMP dCMP deaminase zinc-binding	-	-	3.5.4.3	ko:K01487	ko00230,ko01100,map00230,map01100	-	R01676	RC00204	ko00000,ko00001,ko01000	-	-	-	dCMP_cyt_deam_1
HKD2_k127_6517867_0	1121403.AUCV01000001_gene746	7.685e-181	576.0	COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,42MY8@68525|delta/epsilon subdivisions,2WM3Q@28221|Deltaproteobacteria	28221|Deltaproteobacteria	IQ	Belongs to the beta-ketoacyl-ACP synthases family	fabB	-	2.3.1.41	ko:K00647	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
HKD2_k127_6517867_1	1167006.UWK_00813	3.281e-104	347.0	COG4221@1|root,COG4221@2|Bacteria,1MUF8@1224|Proteobacteria,42KZX@68525|delta/epsilon subdivisions,2WM2N@28221|Deltaproteobacteria,2MNYQ@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Enoyl-(Acyl carrier protein) reductase	-	-	1.1.1.381	ko:K16066	ko00240,ko00260,ko01100,map00240,map00260,map01100	-	R09289,R10851,R10852	RC00087,RC00525,RC03288	ko00000,ko00001,ko01000	-	-	-	adh_short
HKD2_k127_6517867_3	1167006.UWK_00388	1.255e-67	235.0	COG1528@1|root,COG1528@2|Bacteria,1R9ZC@1224|Proteobacteria,42S74@68525|delta/epsilon subdivisions,2WNFJ@28221|Deltaproteobacteria,2MK9C@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Iron-storage protein	ftn	-	1.16.3.2	ko:K02217	-	-	-	-	ko00000,ko01000	-	-	-	Ferritin
HKD2_k127_6517867_5	1121403.AUCV01000001_gene751	7.38e-45	168.0	COG1413@1|root,COG1413@2|Bacteria,1R6G4@1224|Proteobacteria,42T2X@68525|delta/epsilon subdivisions,2WPNC@28221|Deltaproteobacteria,2MKIT@213118|Desulfobacterales	28221|Deltaproteobacteria	C	lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,HEAT_EZ
HKD2_k127_653512_27	561231.Pecwa_0139	7.734e-21	92.0	COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,1RR4F@1236|Gammaproteobacteria,1MTZN@122277|Pectobacterium	1236|Gammaproteobacteria	L	PFAM Integrase catalytic region	insF	GO:0008150,GO:0009987,GO:0032196	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve
HKD2_k127_653512_22	661367.LLO_1974	1.617e-44	163.0	COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,1RR4F@1236|Gammaproteobacteria,1JDF5@118969|Legionellales	118969|Legionellales	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_653512_3	1121403.AUCV01000042_gene136	1.47e-174	550.0	COG0752@1|root,COG0752@2|Bacteria,1MVCJ@1224|Proteobacteria,42MNQ@68525|delta/epsilon subdivisions,2WJJW@28221|Deltaproteobacteria,2MI7B@213118|Desulfobacterales	28221|Deltaproteobacteria	J	PFAM glycyl-tRNA synthetase alpha subunit	glyQ	-	6.1.1.14	ko:K01878	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iAF987.Gmet_2942	tRNA-synt_2e
HKD2_k127_653512_24	1167006.UWK_00804	8.357e-42	158.0	COG1832@1|root,COG1832@2|Bacteria,1N03D@1224|Proteobacteria,42TZA@68525|delta/epsilon subdivisions,2WRHK@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	CoA-binding domain protein	-	-	-	ko:K06929	-	-	-	-	ko00000	-	-	-	CoA_binding_2
HKD2_k127_653512_0	1121403.AUCV01000042_gene135	0.0	1420.0	COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,42M4I@68525|delta/epsilon subdivisions,2WJHM@28221|Deltaproteobacteria,2MI09@213118|Desulfobacterales	28221|Deltaproteobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
HKD2_k127_653512_19	1121403.AUCV01000042_gene134	1.65e-66	229.0	COG1952@1|root,COG1952@2|Bacteria,1RI75@1224|Proteobacteria,42XGB@68525|delta/epsilon subdivisions,2WSSG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	U	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA	-	-	-	ko:K03071	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03110	3.A.5	-	-	SecB
HKD2_k127_653512_7	1121403.AUCV01000042_gene133	4.342e-139	455.0	2DZVP@1|root,32VK8@2|Bacteria,1P3DR@1224|Proteobacteria,43206@68525|delta/epsilon subdivisions,2WWWR@28221|Deltaproteobacteria,2MNXQ@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_653512_2	1121403.AUCV01000042_gene132	6.27e-183	589.0	COG4796@1|root,COG4796@2|Bacteria,1QUXY@1224|Proteobacteria,43D2W@68525|delta/epsilon subdivisions,2WNS3@28221|Deltaproteobacteria,2MNS9@213118|Desulfobacterales	28221|Deltaproteobacteria	U	Bacterial type II and III secretion system protein	-	-	-	ko:K12282	-	-	-	-	ko00000,ko02044	-	-	-	Secretin
HKD2_k127_653512_10	1121403.AUCV01000042_gene131	1.381e-115	390.0	COG0457@1|root,COG4796@1|root,COG0457@2|Bacteria,COG4796@2|Bacteria,1P75D@1224|Proteobacteria	1224|Proteobacteria	U	Secretin and TonB N terminus short domain	-	-	-	ko:K02666	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	AMIN,STN
HKD2_k127_653512_26	1121403.AUCV01000042_gene130	1.506e-32	135.0	COG3168@1|root,COG3168@2|Bacteria	2|Bacteria	NU	Pilus assembly protein, PilP	pilP	-	-	ko:K02664,ko:K02665	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilP
HKD2_k127_653512_18	1167006.UWK_00797	3.889e-70	243.0	COG3167@1|root,COG3167@2|Bacteria,1RBGW@1224|Proteobacteria,42S1V@68525|delta/epsilon subdivisions,2WNDR@28221|Deltaproteobacteria,2MJVB@213118|Desulfobacterales	28221|Deltaproteobacteria	NU	PFAM Pilus assembly protein PilO	pilO	-	-	ko:K02664	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilO
HKD2_k127_653512_23	1167006.UWK_00796	3.43e-42	162.0	COG3166@1|root,COG3166@2|Bacteria,1Q1I0@1224|Proteobacteria,42W65@68525|delta/epsilon subdivisions,2WS79@28221|Deltaproteobacteria,2MK8I@213118|Desulfobacterales	28221|Deltaproteobacteria	NU	PFAM Fimbrial assembly	pilN	-	-	ko:K02663	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilN
HKD2_k127_653512_8	1121403.AUCV01000042_gene127	1.534e-128	421.0	COG4972@1|root,COG4972@2|Bacteria,1MX8P@1224|Proteobacteria,42M36@68525|delta/epsilon subdivisions,2WJFJ@28221|Deltaproteobacteria,2MID0@213118|Desulfobacterales	28221|Deltaproteobacteria	NU	TIGRFAM type IV pilus assembly protein PilM	pilM	-	-	ko:K02662	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilM_2
HKD2_k127_653512_14	1121403.AUCV01000042_gene126	1.694e-93	312.0	COG0681@1|root,COG0681@2|Bacteria,1MXUF@1224|Proteobacteria,42NJE@68525|delta/epsilon subdivisions,2WKMA@28221|Deltaproteobacteria,2MIAI@213118|Desulfobacterales	28221|Deltaproteobacteria	U	Belongs to the peptidase S26 family	lepB	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24,Peptidase_S26
HKD2_k127_653512_6	1121403.AUCV01000042_gene125	8.685e-148	473.0	COG0540@1|root,COG0540@2|Bacteria,1MWAB@1224|Proteobacteria,42NMR@68525|delta/epsilon subdivisions,2WJQR@28221|Deltaproteobacteria,2MIUY@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Belongs to the ATCase OTCase family	pyrB	GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
HKD2_k127_653512_4	589865.DaAHT2_2316	1.031e-172	552.0	COG0044@1|root,COG0044@2|Bacteria,1MVXY@1224|Proteobacteria,42MJ9@68525|delta/epsilon subdivisions,2WJH8@28221|Deltaproteobacteria,2MI0K@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily	pyrC	GO:0003674,GO:0003824,GO:0004038,GO:0004151,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006144,GO:0006145,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016787,GO:0016810,GO:0016812,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046113,GO:0046390,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
HKD2_k127_653512_15	1167006.UWK_00791	8.158e-92	308.0	COG0603@1|root,COG0603@2|Bacteria,1MU5V@1224|Proteobacteria,42MKZ@68525|delta/epsilon subdivisions,2WING@28221|Deltaproteobacteria,2MIYB@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))	queC	-	6.3.4.20	ko:K06920	ko00790,ko01100,map00790,map01100	-	R09978	RC00959	ko00000,ko00001,ko01000,ko03016	-	-	iAF987.Gmet_3075	QueC
HKD2_k127_653512_17	1121403.AUCV01000042_gene123	3.021e-84	287.0	COG1489@1|root,COG1489@2|Bacteria,1MUC3@1224|Proteobacteria,42QXT@68525|delta/epsilon subdivisions,2WN0R@28221|Deltaproteobacteria,2MJ9Y@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Belongs to the SfsA family	sfsA	-	-	ko:K06206	-	-	-	-	ko00000	-	-	-	SfsA
HKD2_k127_653512_1	1121403.AUCV01000042_gene122	3.937e-216	676.0	COG0057@1|root,COG0057@2|Bacteria,1R8ZT@1224|Proteobacteria,42PY6@68525|delta/epsilon subdivisions,2WKEI@28221|Deltaproteobacteria,2MII4@213118|Desulfobacterales	28221|Deltaproteobacteria	G	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family	-	-	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Gp_dh_C,Gp_dh_N
HKD2_k127_653512_5	1167006.UWK_00787	9.762e-172	548.0	COG0126@1|root,COG0126@2|Bacteria,1MUNU@1224|Proteobacteria,42N4P@68525|delta/epsilon subdivisions,2WJ0B@28221|Deltaproteobacteria,2MJ55@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Belongs to the phosphoglycerate kinase family	pgk	-	2.7.2.3	ko:K00927	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01512	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
HKD2_k127_653512_12	1167006.UWK_00786	8.041e-98	325.0	COG0149@1|root,COG0149@2|Bacteria,1MWK5@1224|Proteobacteria,42MIF@68525|delta/epsilon subdivisions,2WIQF@28221|Deltaproteobacteria,2MHQ0@213118|Desulfobacterales	28221|Deltaproteobacteria	G	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)	tpiA	-	5.3.1.1	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01015	RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	TIM
HKD2_k127_653512_25	589865.DaAHT2_0038	1.051e-33	134.0	COG1314@1|root,COG1314@2|Bacteria,1NJ1D@1224|Proteobacteria,42TKW@68525|delta/epsilon subdivisions,2WRA3@28221|Deltaproteobacteria,2MKYR@213118|Desulfobacterales	28221|Deltaproteobacteria	U	PFAM Preprotein translocase SecG subunit	secG	-	-	ko:K03075	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecG
HKD2_k127_653512_28	1296415.JACC01000002_gene3188	3.562e-16	91.0	COG3250@1|root,COG3250@2|Bacteria	2|Bacteria	G	beta-galactosidase activity	lacM	-	3.2.1.23,3.2.1.35,3.2.1.51,3.2.1.97	ko:K01190,ko:K01197,ko:K01206,ko:K17624	ko00052,ko00511,ko00531,ko00600,ko01100,map00052,map00511,map00531,map00600,map01100	M00076,M00077	R01105,R01678,R03355,R04783,R06114,R07824,R07825,R10905	RC00049,RC00452	ko00000,ko00001,ko00002,ko00536,ko00537,ko01000,ko02042,ko04147	-	GH101,GH29	-	Bgal_small_N,DUF5011,F5_F8_type_C,Glyco_hydro_2_C,NPCBM,Peptidase_M60
HKD2_k127_653512_13	1167006.UWK_01753	7.965e-95	315.0	COG3155@1|root,COG3155@2|Bacteria,1MW2K@1224|Proteobacteria,42R54@68525|delta/epsilon subdivisions,2WMNZ@28221|Deltaproteobacteria,2MJJV@213118|Desulfobacterales	28221|Deltaproteobacteria	Q	PFAM ThiJ PfpI domain protein	elbB	-	-	-	-	-	-	-	-	-	-	-	DJ-1_PfpI
HKD2_k127_653512_21	1121403.AUCV01000032_gene2902	8.389e-57	202.0	COG0634@1|root,COG0634@2|Bacteria,1NRT8@1224|Proteobacteria,42SNI@68525|delta/epsilon subdivisions,2WPFN@28221|Deltaproteobacteria,2MKAJ@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Belongs to the purine pyrimidine phosphoribosyltransferase family	hpt	-	2.4.2.8	ko:K00760	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	-	R00190,R01132,R01229,R02142,R08237,R08238,R08245	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	Pribosyltran
HKD2_k127_653512_9	1167006.UWK_01757	8.054e-120	387.0	COG4656@1|root,COG4656@2|Bacteria,1MWAX@1224|Proteobacteria,42NJM@68525|delta/epsilon subdivisions,2WJJB@28221|Deltaproteobacteria,2MHNS@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Methylene-tetrahydrofolate reductase C terminal	-	-	-	-	-	-	-	-	-	-	-	-	MTHFR_C
HKD2_k127_653512_20	1167006.UWK_01756	3.781e-59	209.0	COG1908@1|root,COG1908@2|Bacteria,1MZ7V@1224|Proteobacteria,42UHS@68525|delta/epsilon subdivisions,2WQMX@28221|Deltaproteobacteria,2MQ23@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM methyl-viologen-reducing hydrogenase delta subunit	-	-	-	-	-	-	-	-	-	-	-	-	FlpD
HKD2_k127_653512_16	1167006.UWK_01755	1.383e-88	299.0	COG1149@1|root,COG1150@1|root,COG1149@2|Bacteria,COG1150@2|Bacteria,1N2IK@1224|Proteobacteria,42RP6@68525|delta/epsilon subdivisions,2WNP3@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03390	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4_17
HKD2_k127_653512_11	338963.Pcar_0428	2.743e-103	350.0	COG2067@1|root,COG2067@2|Bacteria,1MV7W@1224|Proteobacteria,42NZ4@68525|delta/epsilon subdivisions,2WQTT@28221|Deltaproteobacteria,43VJV@69541|Desulfuromonadales	28221|Deltaproteobacteria	I	Outer membrane protein transport protein (OMPP1/FadL/TodX)	-	-	-	ko:K06076	-	-	-	-	ko00000,ko02000	1.B.9	-	-	Toluene_X
HKD2_k127_6536483_1	1121403.AUCV01000010_gene1409	4.649e-195	617.0	COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,42M5E@68525|delta/epsilon subdivisions,2WIV6@28221|Deltaproteobacteria,2MISJ@213118|Desulfobacterales	28221|Deltaproteobacteria	J	ribonuclease Rne Rng family	cafA	-	-	ko:K08301	-	-	-	-	ko00000,ko01000,ko03009,ko03019	-	-	-	RNase_E_G,S1
HKD2_k127_6536483_3	1121403.AUCV01000010_gene1408	2.059e-158	514.0	COG0739@1|root,COG0739@2|Bacteria,1NESH@1224|Proteobacteria,42MGB@68525|delta/epsilon subdivisions,2WJ7F@28221|Deltaproteobacteria,2MI1U@213118|Desulfobacterales	28221|Deltaproteobacteria	M	PFAM peptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
HKD2_k127_6536483_2	1121403.AUCV01000010_gene1407	3.385e-170	550.0	COG0795@1|root,COG0795@2|Bacteria,1MUF2@1224|Proteobacteria,42NYD@68525|delta/epsilon subdivisions,2WKHT@28221|Deltaproteobacteria,2MHU9@213118|Desulfobacterales	28221|Deltaproteobacteria	S	permease YjgP YjgQ family	lptF	-	-	ko:K07091	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko02000	1.B.42.1	-	-	YjgP_YjgQ
HKD2_k127_6536483_6	1121403.AUCV01000010_gene1406	1.71e-80	279.0	COG0392@1|root,COG0392@2|Bacteria,1MVZ8@1224|Proteobacteria,42WVD@68525|delta/epsilon subdivisions	1224|Proteobacteria	S	Lysylphosphatidylglycerol synthase TM region	-	-	-	ko:K07027	-	-	-	-	ko00000,ko02000	4.D.2	-	-	LPG_synthase_TM
HKD2_k127_6536483_4	1121403.AUCV01000010_gene1405	2.744e-158	509.0	COG0859@1|root,COG0859@2|Bacteria,1PQIG@1224|Proteobacteria,42MUM@68525|delta/epsilon subdivisions,2WPZT@28221|Deltaproteobacteria,2MN6W@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Glycosyltransferase family 9 (heptosyltransferase)	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_9
HKD2_k127_6536483_5	269799.Gmet_1651	1.621e-107	368.0	COG0845@1|root,COG0845@2|Bacteria,1MW65@1224|Proteobacteria,42NJG@68525|delta/epsilon subdivisions,2WJ8R@28221|Deltaproteobacteria,43US6@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Biotin-lipoyl like	-	-	-	ko:K07799	ko02020,map02020	M00648	-	-	ko00000,ko00001,ko00002,ko02000	8.A.1	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
HKD2_k127_6536483_0	1304885.AUEY01000004_gene958	0.0	1347.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJ8D@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296,ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
HKD2_k127_6547582_3	1125863.JAFN01000001_gene1862	1.441e-50	180.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,42P18@68525|delta/epsilon subdivisions,2WKFV@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02033,ko:K12369,ko:K13890	ko02010,ko02024,map02010,map02024	M00239,M00324,M00348	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.11	-	-	BPD_transp_1
HKD2_k127_6547582_2	1125863.JAFN01000001_gene1863	3.458e-140	453.0	COG1173@1|root,COG1173@2|Bacteria,1MW3R@1224|Proteobacteria,43AQ5@68525|delta/epsilon subdivisions,2X63Y@28221|Deltaproteobacteria	28221|Deltaproteobacteria	EP	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
HKD2_k127_6547582_1	1125863.JAFN01000001_gene1864	1.817e-152	491.0	COG1748@1|root,COG1748@2|Bacteria,1MY1G@1224|Proteobacteria,43B3P@68525|delta/epsilon subdivisions,2WM2X@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Saccharopine dehydrogenase C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Sacchrp_dh_C,Sacchrp_dh_NADP
HKD2_k127_6547582_0	1121405.dsmv_1318	3.246e-163	524.0	COG0686@1|root,COG0686@2|Bacteria,1MXDG@1224|Proteobacteria,4318C@68525|delta/epsilon subdivisions,2WWVN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Alanine dehydrogenase/PNT, N-terminal domain	-	-	1.5.1.7,1.5.1.8,1.5.1.9	ko:K00290,ko:K14157	ko00300,ko00310,ko01100,ko01110,ko01130,ko01230,map00300,map00310,map01100,map01110,map01130,map01230	M00030,M00032	R00715,R00716,R02313	RC00215,RC00217,RC00225,RC01532	ko00000,ko00001,ko00002,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
HKD2_k127_6547582_4	1123013.AUIC01000005_gene1372	0.0009967	46.0	COG2203@1|root,COG3835@1|root,COG2203@2|Bacteria,COG3835@2|Bacteria,2I3S0@201174|Actinobacteria	201174|Actinobacteria	T	Pfam GAF	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HTH_30
HKD2_k127_6597323_2	443143.GM18_3125	8.842e-24	104.0	COG0835@1|root,COG0835@2|Bacteria,1RAH1@1224|Proteobacteria,42SH0@68525|delta/epsilon subdivisions,2WPFU@28221|Deltaproteobacteria,43UNN@69541|Desulfuromonadales	28221|Deltaproteobacteria	NT	Two component signalling adaptor domain	cheW34H-1	-	-	ko:K03408	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheW
HKD2_k127_6597323_0	1304885.AUEY01000005_gene859	2.747e-218	702.0	COG0643@1|root,COG0643@2|Bacteria,1MUAG@1224|Proteobacteria,42M6Q@68525|delta/epsilon subdivisions,2WJ5U@28221|Deltaproteobacteria,2MJ5N@213118|Desulfobacterales	28221|Deltaproteobacteria	NT	Signal transducing histidine kinase, homodimeric	cheA34H	-	2.7.13.3	ko:K03407	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt
HKD2_k127_6597323_1	243231.GSU1289	9.268e-46	168.0	COG0745@1|root,COG0745@2|Bacteria,1RHDD@1224|Proteobacteria,42SAC@68525|delta/epsilon subdivisions,2WP7J@28221|Deltaproteobacteria,43SMK@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	Response regulator receiver domain	cheY34H-1	-	-	ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	Response_reg
HKD2_k127_6610485_0	335543.Sfum_1830	2.344e-94	321.0	COG3581@1|root,COG3581@2|Bacteria,1N1N8@1224|Proteobacteria,42UB7@68525|delta/epsilon subdivisions,2WQ9V@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	4 iron, 4 sulfur cluster binding	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6610485_1	335543.Sfum_1829	1.535e-86	295.0	COG1924@1|root,COG3580@1|root,COG1924@2|Bacteria,COG3580@2|Bacteria,1PKG6@1224|Proteobacteria,42MY4@68525|delta/epsilon subdivisions,2WJFI@28221|Deltaproteobacteria,2MQ8R@213462|Syntrophobacterales	28221|Deltaproteobacteria	I	BadF BadG BcrA BcrD	-	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG,DUF2229
HKD2_k127_6620460_7	1337093.MBE-LCI_1696	4.261e-107	366.0	COG4642@1|root,COG4642@2|Bacteria,1P07C@1224|Proteobacteria,2TVGQ@28211|Alphaproteobacteria,2P7VD@245186|Loktanella	28211|Alphaproteobacteria	S	Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases.	-	-	-	-	-	-	-	-	-	-	-	-	MORN
HKD2_k127_6620460_12	1121403.AUCV01000001_gene859	2.84e-57	207.0	COG1514@1|root,COG1514@2|Bacteria,1RDB2@1224|Proteobacteria,42TMM@68525|delta/epsilon subdivisions,2WQ6S@28221|Deltaproteobacteria,2MKHV@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester	-	-	3.1.4.58	ko:K01975	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	LigT_PEase
HKD2_k127_6620460_11	1121403.AUCV01000004_gene1928	7.781e-69	238.0	COG0558@1|root,COG0558@2|Bacteria,1RCZ7@1224|Proteobacteria,42QQ4@68525|delta/epsilon subdivisions,2WQGH@28221|Deltaproteobacteria,2MJJ6@213118|Desulfobacterales	28221|Deltaproteobacteria	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pgsA	-	2.7.8.5	ko:K00995	ko00564,ko01100,map00564,map01100	-	R01801	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
HKD2_k127_6620460_13	1167006.UWK_00672	5.063e-44	169.0	COG0741@1|root,COG0741@2|Bacteria,1MZ4X@1224|Proteobacteria,42TVX@68525|delta/epsilon subdivisions,2WP4F@28221|Deltaproteobacteria,2MKAW@213118|Desulfobacterales	28221|Deltaproteobacteria	M	PFAM Transglycosylase SLT domain	-	-	-	ko:K08309	-	-	-	-	ko00000,ko01000,ko01011	-	GH23	-	DUF4124,SLT
HKD2_k127_6620460_9	1121403.AUCV01000004_gene1930	1.426e-102	342.0	COG0176@1|root,COG0176@2|Bacteria,1MWQ8@1224|Proteobacteria,42M39@68525|delta/epsilon subdivisions,2WJEZ@28221|Deltaproteobacteria,2MI50@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway	tal	-	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
HKD2_k127_6620460_15	1121403.AUCV01000004_gene1931	3.475e-19	90.0	COG3350@1|root,COG3350@2|Bacteria,1NGJJ@1224|Proteobacteria,42XCW@68525|delta/epsilon subdivisions,2WSVQ@28221|Deltaproteobacteria,2MMBE@213118|Desulfobacterales	28221|Deltaproteobacteria	S	monooxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	YHS
HKD2_k127_6620460_14	177439.DP0430	2.916e-37	150.0	COG0801@1|root,COG0801@2|Bacteria,1MZH8@1224|Proteobacteria,42TJ2@68525|delta/epsilon subdivisions,2WQ4P@28221|Deltaproteobacteria,2MKCE@213118|Desulfobacterales	28221|Deltaproteobacteria	H	TIGRFAM 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	-	2.7.6.3	ko:K00950	ko00790,ko01100,map00790,map01100	M00126,M00841	R03503	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	HPPK
HKD2_k127_6620460_5	1121403.AUCV01000004_gene1933	1.187e-130	421.0	COG0289@1|root,COG0289@2|Bacteria,1MUCT@1224|Proteobacteria,42N84@68525|delta/epsilon subdivisions,2WJKT@28221|Deltaproteobacteria,2MPW5@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Dihydrodipicolinate reductase, C-terminus	dapB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008839,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019752,GO:0019877,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576	1.17.1.8	ko:K00215	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R04198,R04199	RC00478	ko00000,ko00001,ko00002,ko01000	-	-	-	DapB_C,DapB_N
HKD2_k127_6620460_3	1167006.UWK_00677	1.337e-139	449.0	COG0329@1|root,COG0329@2|Bacteria,1MUCM@1224|Proteobacteria,42M0X@68525|delta/epsilon subdivisions,2WK4D@28221|Deltaproteobacteria,2MHXX@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	dapA	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
HKD2_k127_6620460_8	1121403.AUCV01000004_gene1935	6.577e-103	343.0	COG0253@1|root,COG0253@2|Bacteria,1MWDH@1224|Proteobacteria,42MRX@68525|delta/epsilon subdivisions,2WMP4@28221|Deltaproteobacteria,2MJMR@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan	dapF	-	5.1.1.7	ko:K01778	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00527	R02735	RC00302	ko00000,ko00001,ko00002,ko01000	-	-	-	DAP_epimerase
HKD2_k127_6620460_2	1167006.UWK_00679	5.903e-188	595.0	COG0019@1|root,COG0019@2|Bacteria,1MUA6@1224|Proteobacteria,42KZH@68525|delta/epsilon subdivisions,2WIRM@28221|Deltaproteobacteria,2MJBU@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine	lysA	-	4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
HKD2_k127_6620460_6	1121403.AUCV01000004_gene1937	1.449e-107	359.0	COG4733@1|root,COG4733@2|Bacteria,1NA5J@1224|Proteobacteria,42WEQ@68525|delta/epsilon subdivisions,2WSA0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Fibronectin, type III domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6620460_1	1121403.AUCV01000004_gene1938	3.361e-215	682.0	COG0165@1|root,COG0165@2|Bacteria,1MUTU@1224|Proteobacteria,42M7Y@68525|delta/epsilon subdivisions,2WIRN@28221|Deltaproteobacteria,2MHTS@213118|Desulfobacterales	28221|Deltaproteobacteria	E	TIGRFAM argininosuccinate lyase	argH	GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.3.2.1	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01086	RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ASL_C2,Lyase_1,NUDIX
HKD2_k127_6620460_0	1121403.AUCV01000004_gene1939	1.178e-223	697.0	COG0137@1|root,COG0137@2|Bacteria,1MV0Y@1224|Proteobacteria,42N81@68525|delta/epsilon subdivisions,2WJB0@28221|Deltaproteobacteria,2MIV2@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Belongs to the argininosuccinate synthase family. Type 1 subfamily	argG	GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Arginosuc_synth
HKD2_k127_6620460_4	1121403.AUCV01000004_gene1940	1.39e-135	438.0	COG0078@1|root,COG0078@2|Bacteria,1MUFM@1224|Proteobacteria,42M0Q@68525|delta/epsilon subdivisions,2WJ3G@28221|Deltaproteobacteria,2MHVW@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline	argF	GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.1.3.3,2.1.3.9	ko:K00611,ko:K09065	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01398,R07245	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
HKD2_k127_6620460_10	1121403.AUCV01000004_gene1942	6.355e-73	249.0	COG4992@1|root,COG4992@2|Bacteria,1MV3C@1224|Proteobacteria,42MHH@68525|delta/epsilon subdivisions,2WIMW@28221|Deltaproteobacteria,2MHRT@213118|Desulfobacterales	28221|Deltaproteobacteria	E	TIGRFAM acetylornithine and succinylornithine	argD	-	2.6.1.11,2.6.1.17	ko:K00821	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	iAF987.Gmet_0204	Aminotran_3
HKD2_k127_6627570_1	335543.Sfum_2247	4.199e-16	79.0	COG0845@1|root,COG3350@1|root,COG0845@2|Bacteria,COG3350@2|Bacteria,1MVAS@1224|Proteobacteria,42PKU@68525|delta/epsilon subdivisions,2WM5K@28221|Deltaproteobacteria,2MRTA@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K07798	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4,8.A.1	-	-	DUF3347,HlyD_D23
HKD2_k127_6627570_0	1035308.AQYY01000002_gene632	0.0	1665.0	COG2132@1|root,COG2132@2|Bacteria,1TQSU@1239|Firmicutes,24CJP@186801|Clostridia,260KE@186807|Peptococcaceae	186801|Clostridia	Q	Multicopper oxidase	-	-	1.16.3.3	ko:K06324	-	-	-	-	ko00000,ko01000	-	-	-	Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3
HKD2_k127_6627570_2	1232410.KI421421_gene3346	1.101e-09	64.0	COG1359@1|root,COG1359@2|Bacteria,1NGPW@1224|Proteobacteria,42XUS@68525|delta/epsilon subdivisions,2WT6T@28221|Deltaproteobacteria,43V3C@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Antibiotic biosynthesis monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	ABM
HKD2_k127_6635859_2	589865.DaAHT2_0242	4.354e-45	168.0	COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,1MU1Q@1224|Proteobacteria,42ND6@68525|delta/epsilon subdivisions,2WIJS@28221|Deltaproteobacteria,2MHY5@213118|Desulfobacterales	28221|Deltaproteobacteria	G	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	-	4.2.1.136,5.1.99.6	ko:K17758,ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	Carb_kinase,YjeF_N
HKD2_k127_6635859_1	589865.DaAHT2_0243	3.833e-51	185.0	COG0517@1|root,COG0517@2|Bacteria,1QUKQ@1224|Proteobacteria,42TPD@68525|delta/epsilon subdivisions,2WQQ5@28221|Deltaproteobacteria,2MK07@213118|Desulfobacterales	28221|Deltaproteobacteria	S	PFAM CBS domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS
HKD2_k127_6635859_3	880072.Desac_2882	5.042e-42	177.0	COG2203@1|root,COG3829@1|root,COG4191@1|root,COG2203@2|Bacteria,COG3829@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42PZ5@68525|delta/epsilon subdivisions,2WM5Q@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg
HKD2_k127_6635859_0	243231.GSU1444	6.041e-54	203.0	COG2984@1|root,COG2984@2|Bacteria,1Q1HH@1224|Proteobacteria,42UE1@68525|delta/epsilon subdivisions,2WR33@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
HKD2_k127_6647615_0	1121403.AUCV01000001_gene956	5.35e-138	450.0	COG0642@1|root,COG2205@2|Bacteria,1QHXX@1224|Proteobacteria,42NW1@68525|delta/epsilon subdivisions,2WJUF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	PFAM ATP-binding region, ATPase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c
HKD2_k127_6647615_1	1121403.AUCV01000001_gene957	2.518e-89	302.0	COG0826@1|root,COG0826@2|Bacteria,1MUQG@1224|Proteobacteria,42NTQ@68525|delta/epsilon subdivisions,2WITY@28221|Deltaproteobacteria,2MIFP@213118|Desulfobacterales	28221|Deltaproteobacteria	O	PFAM peptidase	-	-	-	ko:K08303	ko05120,map05120	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_U32
HKD2_k127_6663999_0	926569.ANT_16070	7e-116	383.0	COG0006@1|root,COG0006@2|Bacteria,2G6AH@200795|Chloroflexi	200795|Chloroflexi	E	peptidase M24	-	-	3.4.13.9	ko:K01271	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	AMP_N,Creatinase_N,Peptidase_M24
HKD2_k127_6720565_0	1167006.UWK_00752	1.859e-231	735.0	COG4206@1|root,COG4206@2|Bacteria,1MW63@1224|Proteobacteria,43C33@68525|delta/epsilon subdivisions,2X7DR@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	TonB dependent receptor	-	-	-	ko:K02014,ko:K16092	-	-	-	-	ko00000,ko02000	1.B.14,1.B.14.3	-	-	Plug,TonB_dep_Rec
HKD2_k127_6723470_1	1123372.AUIT01000006_gene1380	3.28e-170	556.0	COG0474@1|root,COG0474@2|Bacteria,2GGR5@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	P	Cation transporter/ATPase, N-terminus	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
HKD2_k127_6723470_2	880072.Desac_2740	3.537e-131	429.0	COG1364@1|root,COG1364@2|Bacteria,1MU0T@1224|Proteobacteria,42M6S@68525|delta/epsilon subdivisions,2WJU8@28221|Deltaproteobacteria,2MQD1@213462|Syntrophobacterales	28221|Deltaproteobacteria	E	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate	argJ	GO:0003674,GO:0003824,GO:0004042,GO:0004358,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006592,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.3.1.1,2.3.1.35	ko:K00620	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259,R02282	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	ArgJ
HKD2_k127_6723470_0	880072.Desac_2739	0.0	1190.0	COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,42MMV@68525|delta/epsilon subdivisions,2WIZ4@28221|Deltaproteobacteria,2MQB9@213462|Syntrophobacterales	28221|Deltaproteobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	Helicase_C,SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
HKD2_k127_6765622_4	765913.ThidrDRAFT_0339	3.899e-06	48.0	COG2519@1|root,COG2519@2|Bacteria,1MXAK@1224|Proteobacteria,1RSIH@1236|Gammaproteobacteria,1WWBV@135613|Chromatiales	135613|Chromatiales	J	Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
HKD2_k127_6765622_3	1121403.AUCV01000032_gene2870	3.299e-57	205.0	COG0778@1|root,COG0778@2|Bacteria,1PDTZ@1224|Proteobacteria,42SQ3@68525|delta/epsilon subdivisions,2WPC5@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM Nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
HKD2_k127_6765622_2	1232410.KI421428_gene1001	9.885e-69	239.0	COG3132@1|root,COG3132@2|Bacteria,1RA13@1224|Proteobacteria,42S8C@68525|delta/epsilon subdivisions,2WP10@28221|Deltaproteobacteria,43UDD@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Protein of unknown function, DUF480	-	-	-	ko:K09915	-	-	-	-	ko00000	-	-	-	DUF480
HKD2_k127_6765622_1	269799.Gmet_0258	1.465e-99	341.0	COG0042@1|root,COG0042@2|Bacteria,1MUSM@1224|Proteobacteria,43AZQ@68525|delta/epsilon subdivisions,2X6DX@28221|Deltaproteobacteria,43S9T@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines	-	-	-	-	-	-	-	-	-	-	-	-	Dus
HKD2_k127_6765622_0	589865.DaAHT2_0738	1.04e-130	426.0	COG0477@1|root,COG2814@2|Bacteria,1MVSH@1224|Proteobacteria,42NA4@68525|delta/epsilon subdivisions,2WKTU@28221|Deltaproteobacteria,2MHYA@213118|Desulfobacterales	28221|Deltaproteobacteria	EGP	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_1_like,MFS_3,Sugar_tr
HKD2_k127_6766460_0	497965.Cyan7822_5426	8.233e-99	335.0	COG1409@1|root,COG1409@2|Bacteria	2|Bacteria	S	acid phosphatase activity	phoA	-	3.1.3.1	ko:K01077	ko00730,ko00790,ko01100,ko02020,map00730,map00790,map01100,map02020	M00126	R02135,R04620	RC00017	ko00000,ko00001,ko00002,ko00537,ko01000,ko04147	-	-	-	F5_F8_type_C,Metallophos
HKD2_k127_6766460_1	449447.MAE_21550	1.937e-59	231.0	COG2931@1|root,COG2931@2|Bacteria	2|Bacteria	Q	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	-	-	-	-	-	-	-	-	-	Calx-beta,DUF11,HemolysinCabind,LTD,Peptidase_M10_C
HKD2_k127_6766460_4	471854.Dfer_0264	6.317e-34	151.0	COG4733@1|root,COG4733@2|Bacteria,4NK2V@976|Bacteroidetes,47P6C@768503|Cytophagia	976|Bacteroidetes	G	PFAM Fibronectin type III domain	-	-	-	-	-	-	-	-	-	-	-	-	fn3
HKD2_k127_6766460_5	492774.JQMB01000009_gene3395	6.682e-08	60.0	COG2020@1|root,COG2020@2|Bacteria,1RECR@1224|Proteobacteria,2U6MH@28211|Alphaproteobacteria,4BA0U@82115|Rhizobiaceae	28211|Alphaproteobacteria	O	Isoprenylcysteine carboxyl methyltransferase (ICMT) family	-	-	-	-	-	-	-	-	-	-	-	-	ICMT,PEMT
HKD2_k127_6766460_2	926569.ANT_08030	4.91e-46	181.0	COG1361@1|root,COG3764@1|root,COG1361@2|Bacteria,COG3764@2|Bacteria,2G854@200795|Chloroflexi	200795|Chloroflexi	M	Domain of unknown function DUF11	-	-	-	-	-	-	-	-	-	-	-	-	DUF11
HKD2_k127_6766460_3	509191.AEDB02000022_gene2925	1.448e-44	176.0	COG1404@1|root,COG1404@2|Bacteria,1TQ2M@1239|Firmicutes,24CD5@186801|Clostridia,3WIT1@541000|Ruminococcaceae	186801|Clostridia	O	Subtilase family	-	-	-	ko:K13274,ko:K14645	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002,ko03110	-	-	-	Big_2,Peptidase_S8,SLH
HKD2_k127_6767245_0	756499.Desde_3794	4.284e-47	171.0	COG3333@1|root,COG3333@2|Bacteria,1TPE7@1239|Firmicutes,247UH@186801|Clostridia,263JV@186807|Peptococcaceae	186801|Clostridia	S	PFAM Tripartite tricarboxylate transporter TctA family	-	-	-	ko:K07793	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctA
HKD2_k127_6767245_2	1353537.TP2_06625	3.487e-05	52.0	2CQ1K@1|root,32SKA@2|Bacteria,1N0TP@1224|Proteobacteria,2U7ZA@28211|Alphaproteobacteria,2XNF8@285107|Thioclava	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter TctB family	-	-	-	-	-	-	-	-	-	-	-	-	TctB
HKD2_k127_6767245_1	1009370.ALO_13519	1.318e-05	55.0	COG0471@1|root,COG0471@2|Bacteria,1TRFV@1239|Firmicutes,4H2V0@909932|Negativicutes	909932|Negativicutes	P	transporter	-	-	-	ko:K03319	-	-	-	-	ko00000	2.A.47	-	-	Na_sulph_symp
HKD2_k127_6770575_1	177439.DP1812	3.373e-243	758.0	COG0439@1|root,COG0439@2|Bacteria,1PJSC@1224|Proteobacteria,42PDE@68525|delta/epsilon subdivisions,2WMHH@28221|Deltaproteobacteria,2MPT1@213118|Desulfobacterales	28221|Deltaproteobacteria	I	Pfam:CPSase_L_chain	accC	-	-	-	-	-	-	-	-	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
HKD2_k127_6770575_0	177439.DP1813	0.0	1086.0	COG0777@1|root,COG0825@1|root,COG0777@2|Bacteria,COG0825@2|Bacteria,1MURN@1224|Proteobacteria,42NC2@68525|delta/epsilon subdivisions,2WKA3@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA	accA	-	2.1.3.15,6.4.1.2	ko:K01962,ko:K01963	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	ACCA
HKD2_k127_6803112_0	1121403.AUCV01000002_gene598	1.05e-222	711.0	COG1198@1|root,COG1198@2|Bacteria,1MUUZ@1224|Proteobacteria,42MNH@68525|delta/epsilon subdivisions,2WJ4G@28221|Deltaproteobacteria,2MINK@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	-	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,ResIII
HKD2_k127_6803112_1	439235.Dalk_0338	5.573e-13	74.0	COG3678@1|root,COG3678@2|Bacteria,1NIN7@1224|Proteobacteria,43776@68525|delta/epsilon subdivisions,2X27M@28221|Deltaproteobacteria,2MM9R@213118|Desulfobacterales	28221|Deltaproteobacteria	NPTU	ATP-independent chaperone mediated protein folding	-	-	-	ko:K07803	ko02020,map02020	-	-	-	ko00000,ko00001,ko03110	-	-	-	-
HKD2_k127_6808237_0	933262.AXAM01000126_gene962	3.84e-187	606.0	COG0784@1|root,COG5002@1|root,COG0784@2|Bacteria,COG5002@2|Bacteria,1NC9X@1224|Proteobacteria,43BSJ@68525|delta/epsilon subdivisions,2X73B@28221|Deltaproteobacteria,2MI6A@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_9,Response_reg
HKD2_k127_6876716_5	589865.DaAHT2_1951	1.086e-44	172.0	COG0477@1|root,COG2814@2|Bacteria,1MVSH@1224|Proteobacteria,42NA4@68525|delta/epsilon subdivisions,2WIJM@28221|Deltaproteobacteria	28221|Deltaproteobacteria	EGP	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD2_k127_6876716_9	1206733.BAGC01000010_gene5180	0.0001057	53.0	COG0477@1|root,COG0477@2|Bacteria,2GIUM@201174|Actinobacteria,4FWJ4@85025|Nocardiaceae	201174|Actinobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD2_k127_6876716_8	589865.DaAHT2_1951	2.119e-05	49.0	COG0477@1|root,COG2814@2|Bacteria,1MVSH@1224|Proteobacteria,42NA4@68525|delta/epsilon subdivisions,2WIJM@28221|Deltaproteobacteria	28221|Deltaproteobacteria	EGP	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD2_k127_6876716_6	1499967.BAYZ01000158_gene452	1.718e-40	154.0	COG0727@1|root,COG0727@2|Bacteria	2|Bacteria	S	metal cluster binding	ykgJ	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
HKD2_k127_6876716_7	637905.SVI_3853	9.059e-18	89.0	2E3SC@1|root,32YPX@2|Bacteria,1N7IU@1224|Proteobacteria	1224|Proteobacteria	S	Protein of unknown function (DUF1059)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1059
HKD2_k127_6876716_2	1121403.AUCV01000046_gene1102	1.789e-109	370.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,42NY2@68525|delta/epsilon subdivisions,2WJKQ@28221|Deltaproteobacteria,2MMVD@213118|Desulfobacterales	28221|Deltaproteobacteria	KLT	Protein tyrosine kinase	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	DUF1566,Pkinase
HKD2_k127_6876716_4	1121403.AUCV01000046_gene1101	1.303e-68	241.0	COG0639@1|root,COG0639@2|Bacteria,1MUV1@1224|Proteobacteria,42RNB@68525|delta/epsilon subdivisions,2WNEW@28221|Deltaproteobacteria,2MKAA@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Calcineurin-like phosphoesterase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos_2
HKD2_k127_6876716_3	247490.KSU1_C0048	2.844e-77	279.0	COG2211@1|root,COG2211@2|Bacteria,2IY9C@203682|Planctomycetes	203682|Planctomycetes	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD2_k127_6876716_1	1121033.AUCF01000008_gene5719	7.199e-125	409.0	COG0463@1|root,COG0463@2|Bacteria,1MXC1@1224|Proteobacteria,2TVY5@28211|Alphaproteobacteria,2JYTD@204441|Rhodospirillales	204441|Rhodospirillales	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HKD2_k127_6876716_0	589865.DaAHT2_0986	1.782e-175	563.0	COG1643@1|root,COG1643@2|Bacteria,1MUEQ@1224|Proteobacteria,42MD4@68525|delta/epsilon subdivisions,2WJ7Z@28221|Deltaproteobacteria,2MHYR@213118|Desulfobacterales	28221|Deltaproteobacteria	L	ATP-dependent helicase HrpB	hrpB	-	3.6.4.13	ko:K03579	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,HA2,Helicase_C,HrpB_C
HKD2_k127_6888934_1	1121403.AUCV01000012_gene4102	3.834e-100	331.0	COG0505@1|root,COG0505@2|Bacteria,1MUB9@1224|Proteobacteria,42KZG@68525|delta/epsilon subdivisions,2WIQ5@28221|Deltaproteobacteria,2MIKI@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Belongs to the CarA family	carA	-	6.3.5.5	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_sm_chain,GATase
HKD2_k127_6888934_2	1121403.AUCV01000012_gene4101	3.262e-87	306.0	COG1519@1|root,COG1519@2|Bacteria,1MU9F@1224|Proteobacteria,42PCH@68525|delta/epsilon subdivisions,2WMQM@28221|Deltaproteobacteria,2MJN5@213118|Desulfobacterales	28221|Deltaproteobacteria	M	PFAM Three-deoxy-D-manno-octulosonic-acid transferase domain protein	kdtA	-	2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15	ko:K02527	ko00540,ko01100,map00540,map01100	M00060,M00080	R04658,R05074,R09763	RC00009,RC00077,RC00247	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT30	-	Glycos_transf_N
HKD2_k127_6888934_0	1121403.AUCV01000012_gene4100	1.903e-132	431.0	COG0545@1|root,COG0652@1|root,COG0545@2|Bacteria,COG0652@2|Bacteria,1RDA1@1224|Proteobacteria,43BUM@68525|delta/epsilon subdivisions,2WMFR@28221|Deltaproteobacteria,2MIPP@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD	-	-	5.2.1.8	ko:K01802	-	-	-	-	ko00000,ko01000	-	-	-	FKBP_C,Pro_isomerase
HKD2_k127_6915014_6	1121403.AUCV01000007_gene1230	9.933e-53	189.0	COG0773@1|root,COG0773@2|Bacteria,1MUC5@1224|Proteobacteria,42NMY@68525|delta/epsilon subdivisions,2WJ8S@28221|Deltaproteobacteria,2MHS5@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Belongs to the MurCDEF family	mpl	-	6.3.2.45	ko:K02558	-	-	-	-	ko00000,ko01000	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
HKD2_k127_6915014_9	1121403.AUCV01000007_gene1229	1.191e-12	69.0	2EJAZ@1|root,33D23@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6915014_5	1121403.AUCV01000007_gene1228	1.402e-62	221.0	2C0RW@1|root,2ZBA6@2|Bacteria,1RJAD@1224|Proteobacteria,42SJV@68525|delta/epsilon subdivisions,2WP2Y@28221|Deltaproteobacteria,2MK50@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6915014_0	439235.Dalk_3411	1.271e-179	574.0	COG2200@1|root,COG2200@2|Bacteria,1MVJY@1224|Proteobacteria,42N7E@68525|delta/epsilon subdivisions,2WK3K@28221|Deltaproteobacteria,2MM49@213118|Desulfobacterales	28221|Deltaproteobacteria	T	PFAM EAL domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CBS,EAL,GGDEF
HKD2_k127_6915014_7	1121403.AUCV01000010_gene1356	8.932e-52	189.0	COG0703@1|root,COG0703@2|Bacteria,1MUFJ@1224|Proteobacteria,42RJW@68525|delta/epsilon subdivisions	1224|Proteobacteria	F	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate	aroK	-	2.7.1.71	ko:K00891	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	SKI
HKD2_k127_6915014_1	1122194.AUHU01000005_gene786	6.139e-150	486.0	COG1362@1|root,COG1362@2|Bacteria,1NT1D@1224|Proteobacteria,1RPHR@1236|Gammaproteobacteria,46614@72275|Alteromonadaceae	1236|Gammaproteobacteria	E	M18 family aminopeptidase	apeB	GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0008270,GO:0016787,GO:0019538,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0046872,GO:0046914,GO:0070011,GO:0071704,GO:0140096,GO:1901564	3.4.11.21	ko:K01267	-	-	-	-	ko00000,ko01000,ko01002,ko04131	-	-	-	Peptidase_M18
HKD2_k127_6915014_3	1167006.UWK_02529	1.495e-82	286.0	COG1082@1|root,COG1082@2|Bacteria,1N8KJ@1224|Proteobacteria,42SR1@68525|delta/epsilon subdivisions,2WP5P@28221|Deltaproteobacteria,2MNKD@213118|Desulfobacterales	28221|Deltaproteobacteria	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
HKD2_k127_6915014_4	1121403.AUCV01000008_gene1620	3.829e-68	243.0	COG1357@1|root,COG1357@2|Bacteria,1N7U9@1224|Proteobacteria,42X3G@68525|delta/epsilon subdivisions,2WUJY@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Pentapeptide repeats (9 copies)	-	-	-	-	-	-	-	-	-	-	-	-	Pentapeptide
HKD2_k127_6915014_2	177439.DP1663	2.299e-134	437.0	COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,42MGP@68525|delta/epsilon subdivisions,2WIZ2@28221|Deltaproteobacteria,2MI79@213118|Desulfobacterales	28221|Deltaproteobacteria	L	DNA polymerase III alpha subunit	dnaE	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
HKD2_k127_6915014_8	1121403.AUCV01000008_gene1619	5.351e-50	178.0	COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,42MGP@68525|delta/epsilon subdivisions,2WIZ2@28221|Deltaproteobacteria,2MI79@213118|Desulfobacterales	28221|Deltaproteobacteria	L	DNA polymerase III alpha subunit	dnaE	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
HKD2_k127_6944336_7	1123242.JH636434_gene4641	6.577e-05	52.0	2CK4A@1|root,2ZVBV@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6944336_1	472759.Nhal_0251	6.277e-94	316.0	COG1943@1|root,COG1943@2|Bacteria,1MX0E@1224|Proteobacteria,1RPJH@1236|Gammaproteobacteria,1WWU7@135613|Chromatiales	135613|Chromatiales	L	PFAM Transposase IS200 like	-	-	-	-	-	-	-	-	-	-	-	-	Y1_Tnp
HKD2_k127_6944336_2	941449.dsx2_2169	6.598e-91	310.0	COG0382@1|root,COG0382@2|Bacteria,1RA0E@1224|Proteobacteria,42QUB@68525|delta/epsilon subdivisions,2WMY2@28221|Deltaproteobacteria,2M7V5@213115|Desulfovibrionales	28221|Deltaproteobacteria	H	PFAM UbiA prenyltransferase	-	-	2.5.1.39	ko:K03179	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R05000,R05615	RC00209,RC02895	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
HKD2_k127_6944336_6	1331060.RLDS_21665	5.098e-25	112.0	COG2010@1|root,COG2010@2|Bacteria,1MW1W@1224|Proteobacteria	1224|Proteobacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,Cytochrome_CBB3
HKD2_k127_6944336_4	335543.Sfum_3227	1.271e-77	266.0	COG4244@1|root,COG4892@1|root,COG4244@2|Bacteria,COG4892@2|Bacteria,1N3DP@1224|Proteobacteria,42U1X@68525|delta/epsilon subdivisions,2WQFI@28221|Deltaproteobacteria,2MRX2@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Cytochrome b5-like Heme/Steroid binding domain	-	-	-	-	-	-	-	-	-	-	-	-	CopD,Cyt-b5
HKD2_k127_6944336_5	941449.dsx2_2172	2.615e-71	263.0	COG0500@1|root,COG2226@2|Bacteria,1RKJ7@1224|Proteobacteria,42T77@68525|delta/epsilon subdivisions,2WT2E@28221|Deltaproteobacteria,2M8S2@213115|Desulfovibrionales	28221|Deltaproteobacteria	Q	PFAM Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
HKD2_k127_6944336_3	941449.dsx2_2173	2.558e-86	292.0	COG0500@1|root,COG2226@2|Bacteria,1MX8I@1224|Proteobacteria,42P2Z@68525|delta/epsilon subdivisions,2WNJ6@28221|Deltaproteobacteria,2M9ZP@213115|Desulfovibrionales	28221|Deltaproteobacteria	H	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2)	ubiE	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Ubie_methyltran
HKD2_k127_6944336_0	644968.DFW101_0387	1.66e-135	442.0	COG1082@1|root,COG1082@2|Bacteria,1NHXC@1224|Proteobacteria,42Z1I@68525|delta/epsilon subdivisions,2WTPW@28221|Deltaproteobacteria,2M8FP@213115|Desulfovibrionales	28221|Deltaproteobacteria	G	TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
HKD2_k127_696260_4	1121438.JNJA01000002_gene3488	2.393e-21	95.0	2EHUE@1|root,33BK1@2|Bacteria,1QTGN@1224|Proteobacteria,4369K@68525|delta/epsilon subdivisions,2X0U9@28221|Deltaproteobacteria,2MDF0@213115|Desulfovibrionales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_696260_2	1167006.UWK_02839	1.809e-26	109.0	2EEQ0@1|root,338HQ@2|Bacteria,1NA9V@1224|Proteobacteria,42V4J@68525|delta/epsilon subdivisions,2WS88@28221|Deltaproteobacteria,2MM3P@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_696260_3	1121403.AUCV01000002_gene579	5.166e-25	108.0	COG1324@1|root,COG1324@2|Bacteria,1N6TN@1224|Proteobacteria,42VE1@68525|delta/epsilon subdivisions,2WR7D@28221|Deltaproteobacteria,2MKUG@213118|Desulfobacterales	28221|Deltaproteobacteria	P	PFAM CutA1 divalent ion tolerance protein	cutA	-	-	ko:K03926	-	-	-	-	ko00000	-	-	-	CutA1
HKD2_k127_696260_0	1167006.UWK_02837	1.252e-92	312.0	COG1521@1|root,COG1521@2|Bacteria,1MUYA@1224|Proteobacteria,42MVZ@68525|delta/epsilon subdivisions,2WJ3N@28221|Deltaproteobacteria,2MJ6S@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis	coaX	-	2.7.1.33	ko:K03525	ko00770,ko01100,map00770,map01100	M00120	R02971,R03018,R04391	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_1986	Pan_kinase
HKD2_k127_696260_1	1121403.AUCV01000002_gene581	5.797e-82	282.0	COG1619@1|root,COG1619@2|Bacteria,1MWIY@1224|Proteobacteria,42Q52@68525|delta/epsilon subdivisions,2WJ3S@28221|Deltaproteobacteria,2MICC@213118|Desulfobacterales	28221|Deltaproteobacteria	V	PFAM peptidase U61 LD-carboxypeptidase A	-	-	3.4.17.13	ko:K01297	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_S66
HKD2_k127_6979064_4	67257.JODR01000002_gene1269	7.273e-07	59.0	2DXPV@1|root,32V3V@2|Bacteria,2IDU1@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6979064_0	941449.dsx2_1906	2.468e-103	349.0	COG0515@1|root,COG0515@2|Bacteria,1MVPF@1224|Proteobacteria,42PCV@68525|delta/epsilon subdivisions,2WJHA@28221|Deltaproteobacteria,2M8MX@213115|Desulfovibrionales	28221|Deltaproteobacteria	KLT	serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6979064_2	690850.Desaf_0340	3.421e-17	87.0	COG0589@1|root,COG0589@2|Bacteria,1N2H4@1224|Proteobacteria,42UE7@68525|delta/epsilon subdivisions,2WQV7@28221|Deltaproteobacteria,2MBBS@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	Belongs to the universal stress protein A family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD2_k127_6979064_3	946235.CAER01000059_gene3367	4.42e-07	63.0	COG2804@1|root,COG2804@2|Bacteria,1TPGE@1239|Firmicutes,4HB0C@91061|Bacilli,23K6E@182709|Oceanobacillus	91061|Bacilli	NU	Type II secretion system (T2SS), protein E, N-terminal domain	pilB	-	-	ko:K02243,ko:K02652	-	M00429	-	-	ko00000,ko00002,ko02035,ko02044	3.A.14.1,3.A.15.2	-	-	T2SSE,T2SSE_N
HKD2_k127_6979064_1	1121403.AUCV01000002_gene587	2.789e-86	289.0	COG0241@1|root,COG0241@2|Bacteria,1RDGR@1224|Proteobacteria,42SCB@68525|delta/epsilon subdivisions,2WPEA@28221|Deltaproteobacteria,2MJSF@213118|Desulfobacterales	28221|Deltaproteobacteria	E	D,D-heptose 1,7-bisphosphate phosphatase	gmhB	-	3.1.3.82,3.1.3.83	ko:K03273	ko00540,ko01100,map00540,map01100	M00064	R05647,R09771	RC00017	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hydrolase_like
HKD2_k127_6979346_10	1121403.AUCV01000005_gene329	1.298e-23	100.0	COG0776@1|root,COG0776@2|Bacteria,1MZ7M@1224|Proteobacteria,42TVD@68525|delta/epsilon subdivisions,2WQPX@28221|Deltaproteobacteria,2MKA9@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Belongs to the bacterial histone-like protein family	ihfB	-	-	ko:K05788	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
HKD2_k127_6979346_1	1121403.AUCV01000005_gene328	1.302e-169	545.0	COG0621@1|root,COG0621@2|Bacteria,1MU7N@1224|Proteobacteria,42MRJ@68525|delta/epsilon subdivisions,2WITA@28221|Deltaproteobacteria,2MISV@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12	rimO	-	2.8.4.4	ko:K14441	-	-	R10652	RC00003,RC03217	ko00000,ko01000,ko03009	-	-	-	Radical_SAM,TRAM,UPF0004
HKD2_k127_6979346_7	1121403.AUCV01000005_gene326	5.184e-29	117.0	COG0636@1|root,COG0636@2|Bacteria,1NAIE@1224|Proteobacteria,42VAI@68525|delta/epsilon subdivisions,2WRI4@28221|Deltaproteobacteria,2MKRV@213118|Desulfobacterales	28221|Deltaproteobacteria	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpE	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02110	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_C
HKD2_k127_6979346_3	1121403.AUCV01000005_gene325	5.145e-110	359.0	COG0356@1|root,COG0356@2|Bacteria,1MV87@1224|Proteobacteria,42NR9@68525|delta/epsilon subdivisions,2WKX1@28221|Deltaproteobacteria,2MHZU@213118|Desulfobacterales	28221|Deltaproteobacteria	C	it plays a direct role in the translocation of protons across the membrane	atpB	-	-	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1	-	-	ATP-synt_A
HKD2_k127_6979346_8	1121403.AUCV01000005_gene323	3.212e-26	109.0	COG5336@1|root,COG5336@2|Bacteria,1NHIS@1224|Proteobacteria	1224|Proteobacteria	S	function for this protein is to guide the assembly of the membrane sector of the ATPase enzyme complex	atpI	-	-	ko:K02116	-	-	-	-	ko00000,ko00194	3.A.2.1	-	-	ATPase_gene1
HKD2_k127_6979346_0	1121403.AUCV01000005_gene322	3.632e-217	679.0	COG0001@1|root,COG0001@2|Bacteria,1MUY5@1224|Proteobacteria,42MBF@68525|delta/epsilon subdivisions,2WJQ2@28221|Deltaproteobacteria,2MIIV@213118|Desulfobacterales	28221|Deltaproteobacteria	H	PFAM aminotransferase class-III	hemL	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
HKD2_k127_6979346_6	1121403.AUCV01000005_gene321	1.042e-57	201.0	COG3118@1|root,COG3118@2|Bacteria,1MZBB@1224|Proteobacteria,42TPU@68525|delta/epsilon subdivisions,2WQ1M@28221|Deltaproteobacteria,2MKJV@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Belongs to the thioredoxin family	trxA	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
HKD2_k127_6979346_2	1167006.UWK_01660	1.123e-114	377.0	COG0492@1|root,COG0492@2|Bacteria,1MV15@1224|Proteobacteria,42MHR@68525|delta/epsilon subdivisions,2WIY8@28221|Deltaproteobacteria,2MJC5@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Pyridine nucleotide-disulphide oxidoreductase	trxB	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
HKD2_k127_6979346_4	1121403.AUCV01000005_gene320	1.087e-87	300.0	COG4105@1|root,COG4105@2|Bacteria,1MVS5@1224|Proteobacteria,42RV8@68525|delta/epsilon subdivisions,2WKU0@28221|Deltaproteobacteria,2MJ58@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamD	-	-	ko:K05807	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	YfiO
HKD2_k127_6979346_5	1167006.UWK_01650	1.403e-59	210.0	COG1143@1|root,COG1143@2|Bacteria,1QUMK@1224|Proteobacteria,43BM8@68525|delta/epsilon subdivisions,2X6ZE@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	NIL	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,NIL
HKD2_k127_6987287_1	269799.Gmet_1665	7.032e-150	484.0	COG0845@1|root,COG0845@2|Bacteria,1MU78@1224|Proteobacteria,42P19@68525|delta/epsilon subdivisions,2WK00@28221|Deltaproteobacteria,43UEG@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Biotin-lipoyl like	-	-	-	ko:K19595	-	M00768,M00769	-	-	ko00000,ko00002,ko01504,ko02000	2.A.6.2.25,2.A.6.2.34,8.A.1	-	-	Biotin_lipoyl_2,HlyD_D23
HKD2_k127_6987287_0	269799.Gmet_1664	9.293e-288	892.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJVV@28221|Deltaproteobacteria,43TFN@69541|Desulfuromonadales	28221|Deltaproteobacteria	V	AcrB/AcrD/AcrF family	-	-	-	ko:K03296,ko:K19594	-	M00768,M00769	-	-	ko00000,ko00002,ko01504,ko02000	2.A.6.2,2.A.6.2.25,2.A.6.2.34	-	-	ACR_tran
HKD2_k127_7016333_0	1322246.BN4_10639	6.403e-141	461.0	COG3852@1|root,COG3852@2|Bacteria,1QUKH@1224|Proteobacteria,43BKB@68525|delta/epsilon subdivisions,2X6Y7@28221|Deltaproteobacteria,2MGVM@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	PFAM ATP-binding region ATPase domain protein	-	-	2.7.13.3	ko:K07709	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS_4,PAS_8,sCache_3_2
HKD2_k127_7016333_1	1121441.AUCX01000010_gene103	8.37e-11	68.0	2DT2X@1|root,33IFY@2|Bacteria,1QGSB@1224|Proteobacteria,43661@68525|delta/epsilon subdivisions,2X9G9@28221|Deltaproteobacteria,2MDUJ@213115|Desulfovibrionales	28221|Deltaproteobacteria	-	-	-	-	-	ko:K07803	ko02020,map02020	-	-	-	ko00000,ko00001,ko03110	-	-	-	-
HKD2_k127_7016333_2	484770.UFO1_3776	2.806e-08	58.0	2DQ81@1|root,33577@2|Bacteria,1VJXX@1239|Firmicutes,4H5ZX@909932|Negativicutes	909932|Negativicutes	S	Short C-terminal domain	-	-	-	ko:K08982	-	-	-	-	ko00000	-	-	-	SHOCT
HKD2_k127_7018527_2	1442598.JABW01000020_gene1954	1.594e-07	65.0	COG0431@1|root,COG2202@1|root,COG0431@2|Bacteria,COG2202@2|Bacteria,1NWNJ@1224|Proteobacteria	1224|Proteobacteria	T	PAS domain containing protein	-	-	2.7.13.3,3.1.3.3	ko:K07315,ko:K07675	ko02020,map02020	M00473	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko03021	-	-	-	EAL,GAF_2,GGDEF,HATPase_c,HisKA_2,HisKA_3,PAS_3,PAS_4,PAS_8,PAS_9,SpoIIE,dCache_1
HKD2_k127_7018527_0	338966.Ppro_3572	3.813e-57	226.0	COG2203@1|root,COG3829@1|root,COG4191@1|root,COG4936@1|root,COG2203@2|Bacteria,COG3829@2|Bacteria,COG4191@2|Bacteria,COG4936@2|Bacteria,1RCM9@1224|Proteobacteria,42NFR@68525|delta/epsilon subdivisions,2X7KX@28221|Deltaproteobacteria,43T3C@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	PAS fold	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,PAS_4
HKD2_k127_7018527_1	686340.Metal_0396	1.52e-38	166.0	COG0642@1|root,COG2202@1|root,COG3920@1|root,COG2202@2|Bacteria,COG2205@2|Bacteria,COG3920@2|Bacteria,1MVPJ@1224|Proteobacteria	1224|Proteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	7TMR-DISMED2,7TMR-DISM_7TM,HATPase_c,HATPase_c_2,HisKA_2,PAS,PAS_4,PAS_9,dCache_2
HKD2_k127_7026695_0	1167006.UWK_02468	5.816e-296	917.0	COG2192@1|root,COG2192@2|Bacteria,1MWBA@1224|Proteobacteria,42N15@68525|delta/epsilon subdivisions,2WJ0Y@28221|Deltaproteobacteria,2MHMT@213118|Desulfobacterales	28221|Deltaproteobacteria	O	PFAM Carbamoyltransferase	-	-	-	ko:K00612	-	-	-	-	ko00000,ko01000	-	-	-	Carbam_trans_C,Carbam_trans_N
HKD2_k127_7026695_8	1047013.AQSP01000121_gene2692	9.641e-33	137.0	COG0110@1|root,COG0110@2|Bacteria,2NQ61@2323|unclassified Bacteria	2|Bacteria	S	Hexapeptide repeat of succinyl-transferase	-	-	2.3.1.18	ko:K00633	-	-	-	-	ko00000,ko01000	-	-	-	Hexapep,Hexapep_2
HKD2_k127_7026695_5	1167006.UWK_02472	5.46e-79	278.0	COG0392@1|root,COG0392@2|Bacteria	2|Bacteria	M	lysyltransferase activity	-	-	-	ko:K07027	-	-	-	-	ko00000,ko02000	4.D.2	-	-	LPG_synthase_TM
HKD2_k127_7026695_1	1167006.UWK_00473	2.808e-184	582.0	COG2327@1|root,COG2327@2|Bacteria,1PHRG@1224|Proteobacteria,43EKW@68525|delta/epsilon subdivisions,2X112@28221|Deltaproteobacteria,2MP48@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Polysaccharide pyruvyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	PS_pyruv_trans
HKD2_k127_7026695_2	1167006.UWK_00474	6.056e-174	550.0	COG0451@1|root,COG0451@2|Bacteria,1MX2J@1224|Proteobacteria,42PPG@68525|delta/epsilon subdivisions,2WJGF@28221|Deltaproteobacteria,2MJKB@213118|Desulfobacterales	28221|Deltaproteobacteria	M	epimerase dehydratase	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
HKD2_k127_7026695_4	1167006.UWK_00475	9.259e-87	294.0	29CTD@1|root,2ZZRI@2|Bacteria,1N28P@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7026695_3	1167006.UWK_02464	1.585e-163	534.0	2DW05@1|root,33XX1@2|Bacteria,1NHYZ@1224|Proteobacteria,4303M@68525|delta/epsilon subdivisions,2WVI8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7026695_6	1167006.UWK_02466	7.522e-62	233.0	COG2755@1|root,COG2755@2|Bacteria,1NHW6@1224|Proteobacteria	1224|Proteobacteria	E	lipolytic protein G-D-S-L family	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
HKD2_k127_7026695_7	1167006.UWK_02465	1.008e-46	182.0	COG1835@1|root,COG1835@2|Bacteria	2|Bacteria	I	transferase activity, transferring acyl groups other than amino-acyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
HKD2_k127_70455_4	1121403.AUCV01000008_gene1637	7.826e-29	117.0	COG0228@1|root,COG0228@2|Bacteria,1MZCT@1224|Proteobacteria,42V30@68525|delta/epsilon subdivisions,2WRH7@28221|Deltaproteobacteria,2MKIH@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Belongs to the bacterial ribosomal protein bS16 family	rpsP	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02959	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S16
HKD2_k127_70455_0	1121403.AUCV01000008_gene1636	1.381e-229	717.0	COG0541@1|root,COG0541@2|Bacteria,1MVIA@1224|Proteobacteria,42M94@68525|delta/epsilon subdivisions,2WINB@28221|Deltaproteobacteria,2MHWE@213118|Desulfobacterales	28221|Deltaproteobacteria	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components	ffh	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
HKD2_k127_70455_3	314278.NB231_14973	1.569e-43	161.0	COG1943@1|root,COG1943@2|Bacteria,1RCWW@1224|Proteobacteria,1S3ZJ@1236|Gammaproteobacteria,1X0VZ@135613|Chromatiales	135613|Chromatiales	L	Transposase IS200 like	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
HKD2_k127_70455_2	1116472.MGMO_1c00030	2.743e-67	249.0	COG1943@1|root,COG1943@2|Bacteria,1RCWW@1224|Proteobacteria,1S3ZJ@1236|Gammaproteobacteria,1XF3S@135618|Methylococcales	135618|Methylococcales	L	Transposase IS200 like	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
HKD2_k127_70455_1	1121403.AUCV01000008_gene1635	1.987e-113	374.0	COG0331@1|root,COG0331@2|Bacteria,1MV6N@1224|Proteobacteria,42MKH@68525|delta/epsilon subdivisions,2WIWQ@28221|Deltaproteobacteria,2MI91@213118|Desulfobacterales	28221|Deltaproteobacteria	I	TIGRFAM malonyl CoA-acyl carrier protein transacylase	fabD	-	2.3.1.39	ko:K00645	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	M00082	R01626,R11671	RC00004,RC00039,RC02727	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyl_transf_1
HKD2_k127_70455_5	1167006.UWK_03409	3.113e-08	55.0	COG0597@1|root,COG0597@2|Bacteria,1RGV9@1224|Proteobacteria,42UAT@68525|delta/epsilon subdivisions,2WQ31@28221|Deltaproteobacteria,2MK4S@213118|Desulfobacterales	28221|Deltaproteobacteria	MU	This protein specifically catalyzes the removal of signal peptides from prolipoproteins	lspA	-	3.4.23.36	ko:K03101	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_A8
HKD2_k127_7058359_2	941449.dsx2_1630	2.514e-27	117.0	COG0574@1|root,COG3848@1|root,COG0574@2|Bacteria,COG3848@2|Bacteria,1NSVJ@1224|Proteobacteria,42YMC@68525|delta/epsilon subdivisions,2WUAD@28221|Deltaproteobacteria,2MAPM@213115|Desulfovibrionales	28221|Deltaproteobacteria	GT	protein mobile region	-	-	-	-	-	-	-	-	-	-	-	-	PEP-utilizers
HKD2_k127_7058359_1	1121456.ATVA01000001_gene3075	2.825e-29	130.0	2AHDX@1|root,317QZ@2|Bacteria,1PZ3K@1224|Proteobacteria,435PH@68525|delta/epsilon subdivisions,2X9BN@28221|Deltaproteobacteria,2MA8H@213115|Desulfovibrionales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7058359_0	1322246.BN4_20025	6.163e-53	192.0	COG2204@1|root,COG2204@2|Bacteria,1MYSD@1224|Proteobacteria,42SVG@68525|delta/epsilon subdivisions,2WPRW@28221|Deltaproteobacteria,2MFZ3@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
HKD2_k127_7058359_3	883.DvMF_0705	9.057e-12	67.0	COG0574@1|root,COG3848@1|root,COG0574@2|Bacteria,COG3848@2|Bacteria,1QFX3@1224|Proteobacteria,42PIP@68525|delta/epsilon subdivisions,2WKWI@28221|Deltaproteobacteria,2MG9J@213115|Desulfovibrionales	28221|Deltaproteobacteria	G	PFAM Pyruvate phosphate dikinase, PEP pyruvate-binding	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PPDK_N
HKD2_k127_7063930_2	1504672.669785340	4.512e-53	201.0	COG3931@1|root,COG3931@2|Bacteria,1PWF0@1224|Proteobacteria,2VZYZ@28216|Betaproteobacteria	28216|Betaproteobacteria	E	N-formylglutamate amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	FGase
HKD2_k127_7063930_3	748247.AZKH_1541	7.611e-37	154.0	COG2170@1|root,COG2170@2|Bacteria,1MY35@1224|Proteobacteria,2VNEE@28216|Betaproteobacteria	28216|Betaproteobacteria	H	Glutamate-cysteine ligase family 2(GCS2)	-	-	-	-	-	-	-	-	-	-	-	-	GCS2
HKD2_k127_7063930_1	1123368.AUIS01000003_gene1812	6.296e-91	306.0	COG2170@1|root,COG2170@2|Bacteria,1MY35@1224|Proteobacteria,1SKSY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Glutamate-cysteine ligase family 2(GCS2)	-	-	-	-	-	-	-	-	-	-	-	-	GCS2
HKD2_k127_7063930_0	1232410.KI421415_gene2975	9.646e-202	640.0	COG0189@1|root,COG0189@2|Bacteria,1MX5X@1224|Proteobacteria,42MPG@68525|delta/epsilon subdivisions,2WKW8@28221|Deltaproteobacteria,43UK8@69541|Desulfuromonadales	28221|Deltaproteobacteria	HJ	RimK-like ATPgrasp N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Dala_Dala_lig_C,RLAN,RimK
HKD2_k127_7088096_1	690850.Desaf_0327	1.602e-91	311.0	COG1361@1|root,COG1361@2|Bacteria,1R5HW@1224|Proteobacteria,42R1Y@68525|delta/epsilon subdivisions,2WMXD@28221|Deltaproteobacteria,2M8MB@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	Protein of unknown function (DUF1566)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1566
HKD2_k127_7088096_0	1167006.UWK_00064	5.713e-94	315.0	COG0294@1|root,COG0294@2|Bacteria,1MUIR@1224|Proteobacteria,42MMY@68525|delta/epsilon subdivisions,2WIXA@28221|Deltaproteobacteria,2MITP@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives	folP	-	2.5.1.15,2.7.6.3	ko:K00796,ko:K13941	ko00790,ko01100,map00790,map01100	M00126,M00840,M00841	R03066,R03067,R03503	RC00002,RC00017,RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
HKD2_k127_7112437_1	631362.Thi970DRAFT_01104	1.184e-71	264.0	COG0457@1|root,COG4886@1|root,COG0457@2|Bacteria,COG4886@2|Bacteria,1QN1C@1224|Proteobacteria,1TKDQ@1236|Gammaproteobacteria,1X21G@135613|Chromatiales	135613|Chromatiales	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7112437_0	526222.Desal_1035	4.094e-101	354.0	COG0079@1|root,COG1213@1|root,COG0079@2|Bacteria,COG1213@2|Bacteria,1R0SC@1224|Proteobacteria,43D0X@68525|delta/epsilon subdivisions,2X88T@28221|Deltaproteobacteria,2MHDE@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	Aminotransferase class I and II	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
HKD2_k127_7112437_3	1185876.BN8_02109	6.526e-06	59.0	COG2374@1|root,COG2755@1|root,COG4886@1|root,COG2374@2|Bacteria,COG2755@2|Bacteria,COG4886@2|Bacteria,4NR6Y@976|Bacteroidetes,47SS8@768503|Cytophagia	976|Bacteroidetes	E	PFAM Receptor L domain	-	-	-	-	-	-	-	-	-	-	-	-	Recep_L_domain
HKD2_k127_7112437_2	595460.RRSWK_03790	1.628e-19	104.0	COG1821@1|root,COG1821@2|Bacteria	2|Bacteria	GM	Pfam ATP-grasp domain	-	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_3,ATP-grasp_4,Acetyltransf_10
HKD2_k127_7126233_1	1167006.UWK_00443	2.046e-114	378.0	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,42MMK@68525|delta/epsilon subdivisions,2WJC1@28221|Deltaproteobacteria,2MIZF@213118|Desulfobacterales	28221|Deltaproteobacteria	S	PFAM ABC transporter	-	-	-	ko:K15738	-	-	-	-	ko00000,ko02000	3.A.1.120.6	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
HKD2_k127_7126233_0	555779.Dthio_PD2435	1.11e-191	602.0	COG2873@1|root,COG2873@2|Bacteria,1NQME@1224|Proteobacteria,43DRR@68525|delta/epsilon subdivisions,2X70U@28221|Deltaproteobacteria,2M80T@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	PFAM Cys Met metabolism	metY-1	-	2.5.1.49	ko:K01740	ko00270,ko01100,map00270,map01100	-	R01287,R04859	RC00020,RC02821,RC02848	ko00000,ko00001,ko01000	-	-	-	Cys_Met_Meta_PP
HKD2_k127_7157856_1	1232410.KI421427_gene1299	2.967e-177	570.0	COG0651@1|root,COG0651@2|Bacteria,1MXRW@1224|Proteobacteria,42NFV@68525|delta/epsilon subdivisions,2WJZ0@28221|Deltaproteobacteria,43T2H@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	PFAM NADH Ubiquinone plastoquinone (complex I)	ehrA-2	-	-	ko:K12137	-	-	-	-	ko00000,ko01000	-	-	-	Proton_antipo_M,Proton_antipo_N
HKD2_k127_7157856_4	1232410.KI421427_gene1294	1.177e-111	365.0	COG1143@1|root,COG3260@1|root,COG1143@2|Bacteria,COG3260@2|Bacteria,1QUBE@1224|Proteobacteria,42NH3@68525|delta/epsilon subdivisions,2WJX8@28221|Deltaproteobacteria,43T9P@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	NADH ubiquinone oxidoreductase, 20 Kd subunit	ehrS	-	-	-	-	-	-	-	-	-	-	iAF987.Gmet_2596	Fer4,Fer4_7,Oxidored_q6
HKD2_k127_7157856_0	1232410.KI421427_gene1295	2.577e-188	617.0	COG3261@1|root,COG3261@2|Bacteria,1QUBF@1224|Proteobacteria,42NJH@68525|delta/epsilon subdivisions,2WJ6J@28221|Deltaproteobacteria,43SVB@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Respiratory-chain NADH dehydrogenase, 49 Kd subunit	ehrL	-	-	-	-	-	-	-	-	-	-	-	Complex1_30kDa,Complex1_49kDa
HKD2_k127_7157856_2	1232410.KI421427_gene1296	1.173e-164	530.0	COG0651@1|root,COG0651@2|Bacteria,1MVBA@1224|Proteobacteria,42MG7@68525|delta/epsilon subdivisions,2WIRA@28221|Deltaproteobacteria,43TR1@69541|Desulfuromonadales	28221|Deltaproteobacteria	CP	Proton-conducting membrane transporter	ehrD	-	-	ko:K12141	-	-	-	-	ko00000,ko01000	-	-	-	Proton_antipo_M
HKD2_k127_7157856_5	1232410.KI421427_gene1297	1.456e-83	282.0	COG4237@1|root,COG4237@2|Bacteria,1NAT8@1224|Proteobacteria,42NDW@68525|delta/epsilon subdivisions,2WMF0@28221|Deltaproteobacteria,43SZP@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	hydrogenase 4 membrane	ehrC	-	-	ko:K12140	-	-	-	-	ko00000,ko01000	-	-	-	Oxidored_q2
HKD2_k127_7157856_3	1232410.KI421427_gene1298	4.347e-114	377.0	COG0650@1|root,COG0650@2|Bacteria,1MXV5@1224|Proteobacteria,42NHI@68525|delta/epsilon subdivisions,2WJ3D@28221|Deltaproteobacteria,43T74@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	NADH dehydrogenase	ehrB	-	-	-	-	-	-	-	-	-	-	iAF987.Gmet_0374,iAF987.Gmet_2600	NADHdh
HKD2_k127_7325855_0	1167006.UWK_00106	2.356e-193	615.0	COG1509@1|root,COG1509@2|Bacteria,1MUPJ@1224|Proteobacteria,42MNR@68525|delta/epsilon subdivisions,2WJ70@28221|Deltaproteobacteria,2MICE@213118|Desulfobacterales	28221|Deltaproteobacteria	C	TIGRFAM lysine 2,3-aminomutase YodO family protein	kamA2	-	5.4.3.2	ko:K01843	ko00310,map00310	-	R00461	RC00303	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Fer4_14,LAM_C,Radical_SAM
HKD2_k127_7325855_2	1121405.dsmv_1836	5.591e-144	462.0	COG1181@1|root,COG1181@2|Bacteria,1MX3I@1224|Proteobacteria,42SA1@68525|delta/epsilon subdivisions,2WNIR@28221|Deltaproteobacteria,2MIAX@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Belongs to the D-alanine--D-alanine ligase family	-	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C
HKD2_k127_7325855_1	96561.Dole_1891	1.224e-153	509.0	COG0454@1|root,COG1181@1|root,COG0456@2|Bacteria,COG1181@2|Bacteria,1N4F5@1224|Proteobacteria,42NYM@68525|delta/epsilon subdivisions,2WKTX@28221|Deltaproteobacteria,2MHWK@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Belongs to the D-alanine--D-alanine ligase family	ddlB1	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C
HKD2_k127_7335068_0	388051.AUFE01000016_gene5813	3.585e-220	694.0	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2VHKU@28216|Betaproteobacteria	28216|Betaproteobacteria	S	protein conserved in bacteria	tctA4	-	-	-	-	-	-	-	-	-	-	-	TctA
HKD2_k127_7348381_1	631362.Thi970DRAFT_01104	1.374e-61	221.0	COG0457@1|root,COG4886@1|root,COG0457@2|Bacteria,COG4886@2|Bacteria,1QN1C@1224|Proteobacteria,1TKDQ@1236|Gammaproteobacteria,1X21G@135613|Chromatiales	135613|Chromatiales	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7348381_0	631362.Thi970DRAFT_01103	7.812e-257	815.0	COG0770@1|root,COG3177@1|root,COG0770@2|Bacteria,COG3177@2|Bacteria	2|Bacteria	D	Filamentation induced by cAMP protein fic	murF	GO:0003674,GO:0003824,GO:0005575,GO:0008150,GO:0009405,GO:0016740,GO:0016772,GO:0016773,GO:0018995,GO:0030430,GO:0033643,GO:0033646,GO:0043087,GO:0043656,GO:0043657,GO:0044215,GO:0044216,GO:0044217,GO:0044419,GO:0044605,GO:0050790,GO:0051336,GO:0051704,GO:0065007,GO:0065009	6.3.2.10	ko:K01929,ko:K08599	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	-	R04573,R04617	RC00064,RC00141	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	Ank_2,Fic,Mur_ligase,Mur_ligase_C,Mur_ligase_M
HKD2_k127_7348381_2	1167006.UWK_01728	9.284e-35	139.0	COG2197@1|root,COG2197@2|Bacteria,1N8MU@1224|Proteobacteria,42VM6@68525|delta/epsilon subdivisions,2WXFS@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE
HKD2_k127_7386347_4	596151.DesfrDRAFT_0878	2.037e-30	121.0	COG0526@1|root,COG0526@2|Bacteria,1N728@1224|Proteobacteria,42V0C@68525|delta/epsilon subdivisions,2WRJR@28221|Deltaproteobacteria,2MD57@213115|Desulfovibrionales	28221|Deltaproteobacteria	CO	TIGRFAM redox-active disulfide protein 2	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_3
HKD2_k127_7386347_0	338963.Pcar_0049	7.616e-147	474.0	COG0701@1|root,COG0701@2|Bacteria,1MUN8@1224|Proteobacteria,42MF8@68525|delta/epsilon subdivisions,2WJFH@28221|Deltaproteobacteria,43UJD@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Predicted permease	-	-	-	ko:K07089	-	-	-	-	ko00000	-	-	-	ArsP_1
HKD2_k127_7386347_3	1167006.UWK_01189	4.059e-35	137.0	COG0640@1|root,COG0640@2|Bacteria,1PDZQ@1224|Proteobacteria,42T8C@68525|delta/epsilon subdivisions,2WQWG@28221|Deltaproteobacteria,2MK61@213118|Desulfobacterales	28221|Deltaproteobacteria	K	regulatory protein, arsR	-	-	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	HTH_5
HKD2_k127_7386347_1	292415.Tbd_0367	2.635e-129	436.0	COG1392@1|root,COG1392@2|Bacteria,1MW5V@1224|Proteobacteria,2VM9A@28216|Betaproteobacteria,1KRYF@119069|Hydrogenophilales	119069|Hydrogenophilales	P	Phosphate transport regulator	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7386347_2	1089544.KB912942_gene1762	9.023e-124	421.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,2GK73@201174|Actinobacteria,4E0F3@85010|Pseudonocardiales	201174|Actinobacteria	G	PEP-utilising enzyme, mobile domain	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
HKD2_k127_7386347_5	1120977.JHUX01000003_gene2083	5.667e-09	58.0	2DRA2@1|root,33AVQ@2|Bacteria,1NKZA@1224|Proteobacteria,1SH2Z@1236|Gammaproteobacteria,3NQGN@468|Moraxellaceae	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7421649_2	644282.Deba_2255	1.04e-89	302.0	COG3437@1|root,COG4191@1|root,COG5002@1|root,COG3437@2|Bacteria,COG4191@2|Bacteria,COG5002@2|Bacteria,1RCM9@1224|Proteobacteria,42M1R@68525|delta/epsilon subdivisions,2WK3J@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
HKD2_k127_7421649_0	1121403.AUCV01000004_gene2065	3.209e-197	625.0	COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,42MFC@68525|delta/epsilon subdivisions,2WJ4H@28221|Deltaproteobacteria,2MICW@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor	bioA	-	2.6.1.62	ko:K00833	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03231	RC00006,RC00887	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	AAA_26,Aminotran_3
HKD2_k127_7421649_1	1121403.AUCV01000004_gene2064	1.423e-120	395.0	COG0502@1|root,COG0502@2|Bacteria,1MVFF@1224|Proteobacteria,42NGR@68525|delta/epsilon subdivisions,2WIMA@28221|Deltaproteobacteria,2MJ7W@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism	bioB	-	2.8.1.6,5.4.99.58	ko:K01012,ko:K16180	ko00300,ko00780,ko01100,ko01120,map00300,map00780,map01100,map01120	M00123,M00573,M00577	R01078,R10010	RC00441,RC02995	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_1582	BATS,Radical_SAM
HKD2_k127_7421649_3	1167006.UWK_00958	1.411e-70	245.0	COG0727@1|root,COG0727@2|Bacteria,1RF0Q@1224|Proteobacteria,42RDT@68525|delta/epsilon subdivisions,2WNA7@28221|Deltaproteobacteria,2MPR0@213118|Desulfobacterales	28221|Deltaproteobacteria	S	PFAM Uncharacterised protein family (UPF0153)	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7421649_4	1121403.AUCV01000004_gene2062	2.358e-60	214.0	COG2078@1|root,COG2078@2|Bacteria,1RJP4@1224|Proteobacteria,42SBG@68525|delta/epsilon subdivisions,2WP66@28221|Deltaproteobacteria,2MK8S@213118|Desulfobacterales	28221|Deltaproteobacteria	S	AMMECR1	-	-	-	ko:K09141	-	-	-	-	ko00000	-	-	-	AMMECR1
HKD2_k127_7459996_0	637389.Acaty_c2638	6.299e-74	258.0	2BH64@1|root,33QKM@2|Bacteria,1NR5U@1224|Proteobacteria,1T8UM@1236|Gammaproteobacteria,2NDG0@225057|Acidithiobacillales	225057|Acidithiobacillales	S	Type II secretion system (T2SS), protein E, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	T2SSE_N
HKD2_k127_7459996_1	637390.AFOH01000110_gene2870	1.245e-59	219.0	COG3071@1|root,COG3071@2|Bacteria,1NX21@1224|Proteobacteria,1TE02@1236|Gammaproteobacteria,2NDG3@225057|Acidithiobacillales	225057|Acidithiobacillales	H	Type II secretion system (T2SS), protein E, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	T2SSE_N
HKD2_k127_7497997_0	1265505.ATUG01000002_gene2235	4.876e-111	377.0	COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,42KZR@68525|delta/epsilon subdivisions,2WJ2T@28221|Deltaproteobacteria,2MIVQ@213118|Desulfobacterales	28221|Deltaproteobacteria	NT	histidine kinase HAMP region domain protein	mcp34H-6	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	4HB_MCP_1,HAMP,MCPsignal
HKD2_k127_7608588_0	1121403.AUCV01000025_gene2285	5.6e-199	629.0	COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,42M6W@68525|delta/epsilon subdivisions,2WIZF@28221|Deltaproteobacteria,2MIKW@213118|Desulfobacterales	28221|Deltaproteobacteria	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	relA	-	2.7.6.5	ko:K00951	ko00230,map00230	-	R00429	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
HKD2_k127_7608588_6	1121403.AUCV01000025_gene2286	1.37e-34	137.0	2ED8C@1|root,3374X@2|Bacteria,1NGKT@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Smr
HKD2_k127_7608588_1	1121403.AUCV01000001_gene875	1.072e-71	250.0	COG0545@1|root,COG0545@2|Bacteria,1RDA1@1224|Proteobacteria,42QU4@68525|delta/epsilon subdivisions,2WMRQ@28221|Deltaproteobacteria,2MKCF@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase	-	-	5.2.1.8	ko:K01802,ko:K03772,ko:K03773	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	FKBP_C,FKBP_N
HKD2_k127_7608588_5	944547.ABLL_2651	5.842e-35	143.0	COG2755@1|root,COG2755@2|Bacteria,1MZXI@1224|Proteobacteria,43ANQ@68525|delta/epsilon subdivisions	1224|Proteobacteria	E	OSK domain	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
HKD2_k127_7608588_2	1121430.JMLG01000001_gene2366	5.012e-69	252.0	COG1251@1|root,COG1251@2|Bacteria,1TQYX@1239|Firmicutes,24AD5@186801|Clostridia,2612C@186807|Peptococcaceae	186801|Clostridia	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.6.3.4	ko:K22405	-	-	-	-	ko00000,ko01000	-	-	-	Pyr_redox_2
HKD2_k127_7608588_4	485916.Dtox_2328	1.687e-46	173.0	COG1142@1|root,COG1142@2|Bacteria,1V809@1239|Firmicutes,25E9V@186801|Clostridia,262AX@186807|Peptococcaceae	186801|Clostridia	C	PFAM 4Fe-4S	-	-	-	ko:K00196	ko00633,ko00680,ko00720,ko01120,ko01200,map00633,map00680,map00720,map01120,map01200	-	R07157,R08034	RC00250,RC02800	ko00000,ko00001	-	-	-	Fer4_11,Fer4_4
HKD2_k127_7608588_3	1121422.AUMW01000028_gene3413	1.508e-58	205.0	COG0369@1|root,COG1151@2|Bacteria,1TRSC@1239|Firmicutes,248HQ@186801|Clostridia,25ZZF@186807|Peptococcaceae	186801|Clostridia	C	TIGRFAM Carbon-monoxide dehydrogenase, catalytic subunit	-	-	1.2.7.4	ko:K00198	ko00633,ko00680,ko00720,ko01120,ko01200,map00633,map00680,map00720,map01120,map01200	M00377	R07157,R08034	RC00250,RC02800	ko00000,ko00001,ko00002,ko01000	-	-	-	Prismane
HKD2_k127_7655971_0	1232410.KI421426_gene1458	0.0	1389.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJVV@28221|Deltaproteobacteria,43U04@69541|Desulfuromonadales	28221|Deltaproteobacteria	V	TIGRFAM transporter, hydrophobe amphiphile efflux-1 (HAE1) family	-	-	-	ko:K03296,ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
HKD2_k127_7655971_3	1232410.KI421426_gene1459	4.253e-131	430.0	COG0845@1|root,COG0845@2|Bacteria,1MU78@1224|Proteobacteria,42PGM@68525|delta/epsilon subdivisions,2X5J8@28221|Deltaproteobacteria,43SW4@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
HKD2_k127_7655971_2	1496688.ER33_02795	2.286e-141	456.0	COG2326@1|root,COG2326@2|Bacteria,1G159@1117|Cyanobacteria,22TKN@167375|Cyanobium	1117|Cyanobacteria	S	Polyphosphate kinase 2 (PPK2)	-	-	-	-	-	-	-	-	-	-	-	-	PPK2
HKD2_k127_7655971_6	1232410.KI421424_gene1752	8.47e-106	373.0	COG3264@1|root,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,42N78@68525|delta/epsilon subdivisions,2WM0M@28221|Deltaproteobacteria,43S51@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Mechanosensitive ion channel	mscS-2	-	-	ko:K05802	-	-	-	-	ko00000,ko02000	1.A.23.1.1	-	-	MS_channel
HKD2_k127_7655971_1	56780.SYN_01672	3.227e-282	882.0	COG0243@1|root,COG0243@2|Bacteria,1NR6J@1224|Proteobacteria,43BMM@68525|delta/epsilon subdivisions,2WJJV@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Molybdopterin,Molydop_binding
HKD2_k127_7655971_5	56780.SYN_01673	5.061e-107	355.0	COG0500@1|root,COG2835@1|root,COG2226@2|Bacteria,COG2835@2|Bacteria,1R5RG@1224|Proteobacteria,42NHW@68525|delta/epsilon subdivisions,2WKI8@28221|Deltaproteobacteria,2MR8W@213462|Syntrophobacterales	28221|Deltaproteobacteria	Q	Trm112p-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Trm112p
HKD2_k127_7655971_4	1121403.AUCV01000017_gene4526	5.755e-127	414.0	COG1683@1|root,COG3272@1|root,COG1683@2|Bacteria,COG3272@2|Bacteria,1MXYZ@1224|Proteobacteria,42M4E@68525|delta/epsilon subdivisions,2WKFT@28221|Deltaproteobacteria,2MIBF@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF1722)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1722,DUF523
HKD2_k127_7655971_9	1121918.ARWE01000001_gene191	1.672e-45	168.0	COG0748@1|root,COG0748@2|Bacteria,1N2JV@1224|Proteobacteria,42TYW@68525|delta/epsilon subdivisions,2WQEM@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	PFAM pyridoxamine 5-phosphate	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
HKD2_k127_7655971_7	1121403.AUCV01000052_gene2567	2.48e-86	294.0	COG2197@1|root,COG2197@2|Bacteria,1R3YQ@1224|Proteobacteria,42N0Q@68525|delta/epsilon subdivisions,2WM6W@28221|Deltaproteobacteria,2MIJG@213118|Desulfobacterales	28221|Deltaproteobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,PAS_4,PAS_9
HKD2_k127_7655971_8	96561.Dole_1202	3.993e-55	200.0	COG3040@1|root,COG3040@2|Bacteria,1RDAI@1224|Proteobacteria,42QR5@68525|delta/epsilon subdivisions,2WMSR@28221|Deltaproteobacteria,2MJFW@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Lipocalin-like domain	-	-	-	ko:K03098	-	-	-	-	ko00000,ko04147	-	-	-	Lipocalin_2
HKD2_k127_7655971_12	237368.SCABRO_02097	1.839e-12	70.0	COG0748@1|root,COG0748@2|Bacteria	2|Bacteria	P	coenzyme F420 binding	-	-	1.4.3.5	ko:K00275	ko00750,ko01100,ko01120,map00750,map01100,map01120	M00124	R00277,R00278,R01710,R01711	RC00048,RC00116	ko00000,ko00001,ko00002,ko01000	-	-	-	Putative_PNPOx
HKD2_k127_7659379_1	670292.JH26_05095	7.884e-41	158.0	COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,1MV1V@1224|Proteobacteria,2U6VS@28211|Alphaproteobacteria,1JYYX@119045|Methylobacteriaceae	28211|Alphaproteobacteria	T	CHASE2	cyaK	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	CHASE2,Guanylate_cyc
HKD2_k127_7659379_0	670292.JH26_05090	1.415e-101	361.0	COG0457@1|root,COG3712@1|root,COG4206@1|root,COG0457@2|Bacteria,COG3712@2|Bacteria,COG4206@2|Bacteria,1RJUD@1224|Proteobacteria,2U2AY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	PT	FecR protein	-	-	-	-	-	-	-	-	-	-	-	-	FecR,TPR_16,TPR_19,TPR_8
HKD2_k127_7659379_2	1336235.JAEG01000005_gene3586	7.018e-06	51.0	COG0457@1|root,COG1629@1|root,COG3712@1|root,COG0457@2|Bacteria,COG3712@2|Bacteria,COG4771@2|Bacteria,1RJUD@1224|Proteobacteria,2U2AY@28211|Alphaproteobacteria,4BA1D@82115|Rhizobiaceae	28211|Alphaproteobacteria	PT	FecR protein	-	-	-	-	-	-	-	-	-	-	-	-	FecR,TPR_16,TPR_19,TPR_8,TonB_dep_Rec
HKD2_k127_7693280_2	1121403.AUCV01000008_gene1493	3.45e-44	170.0	COG0617@1|root,COG0617@2|Bacteria,1MU2X@1224|Proteobacteria,42N0S@68525|delta/epsilon subdivisions,2WJR0@28221|Deltaproteobacteria,2MK1F@213118|Desulfobacterales	28221|Deltaproteobacteria	H	metal-dependent phosphohydrolase HD sub	ccaC	-	2.7.7.19	ko:K00970	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	HD,PolyA_pol,PolyA_pol_RNAbd,tRNA_NucTran2_2
HKD2_k127_7693280_1	1167006.UWK_03502	1.005e-45	171.0	COG0526@1|root,COG0526@2|Bacteria,1N3JE@1224|Proteobacteria,42TY7@68525|delta/epsilon subdivisions,2WPYZ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	CO	Thioredoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_3
HKD2_k127_7693280_3	706587.Desti_1336	6.15e-36	142.0	COG2771@1|root,COG2771@2|Bacteria,1NAK1@1224|Proteobacteria,42VEJ@68525|delta/epsilon subdivisions,2WS0Q@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	Protein of unknown function (DUF4019)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4019
HKD2_k127_7693280_0	96561.Dole_0348	1.209e-116	383.0	COG2006@1|root,COG2006@2|Bacteria,1QMGX@1224|Proteobacteria,42PRJ@68525|delta/epsilon subdivisions,2WMFN@28221|Deltaproteobacteria,2MIED@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
HKD2_k127_7739625_3	177439.DP0081	2.416e-54	200.0	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,42N2U@68525|delta/epsilon subdivisions,2WJRR@28221|Deltaproteobacteria,2MI9B@213118|Desulfobacterales	28221|Deltaproteobacteria	V	ABC transporter transmembrane region	-	-	-	ko:K06147,ko:K18890	ko02010,map02010	M00707	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.106,3.A.1.106.13,3.A.1.106.5,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
HKD2_k127_7739625_0	177439.DP0080	3.624e-178	586.0	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,42NCR@68525|delta/epsilon subdivisions,2WKMY@28221|Deltaproteobacteria,2MHTZ@213118|Desulfobacterales	28221|Deltaproteobacteria	V	ABC transporter transmembrane region	-	-	-	ko:K06147,ko:K18889	ko02010,map02010	M00707	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.106,3.A.1.106.13,3.A.1.106.5,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
HKD2_k127_7739625_1	1121405.dsmv_2821	5.521e-80	278.0	COG2214@1|root,COG2214@2|Bacteria,1RAR9@1224|Proteobacteria,42QSU@68525|delta/epsilon subdivisions,2WN19@28221|Deltaproteobacteria,2MI9S@213118|Desulfobacterales	28221|Deltaproteobacteria	O	DnaJ molecular chaperone homology domain	-	-	-	-	-	-	-	-	-	-	-	-	DnaJ
HKD2_k127_7739625_4	1121403.AUCV01000010_gene1368	3.184e-50	181.0	COG2204@1|root,COG2204@2|Bacteria,1QW8K@1224|Proteobacteria,42V8F@68525|delta/epsilon subdivisions,2WRMW@28221|Deltaproteobacteria,2MNUV@213118|Desulfobacterales	28221|Deltaproteobacteria	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
HKD2_k127_7739625_2	1121403.AUCV01000010_gene1367	9.793e-57	203.0	COG2204@1|root,COG3852@1|root,COG2204@2|Bacteria,COG3852@2|Bacteria,1NTTH@1224|Proteobacteria,43BN0@68525|delta/epsilon subdivisions,2X702@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	ABC_sub_bind,HATPase_c,HisKA,PAS_4,PAS_9,Response_reg
HKD2_k127_7780937_3	589865.DaAHT2_2153	1.994e-86	288.0	COG0582@1|root,COG0582@2|Bacteria,1MU23@1224|Proteobacteria,42N7I@68525|delta/epsilon subdivisions,2WJG8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Arm-DNA-bind_3,Phage_integrase
HKD2_k127_7780937_6	392499.Swit_1477	4.964e-44	184.0	COG2114@1|root,COG2203@1|root,COG5000@1|root,COG2114@2|Bacteria,COG2203@2|Bacteria,COG5000@2|Bacteria,1MV1V@1224|Proteobacteria,2TRTY@28211|Alphaproteobacteria,2KCKE@204457|Sphingomonadales	204457|Sphingomonadales	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc
HKD2_k127_7780937_1	1265505.ATUG01000001_gene4652	1.629e-120	420.0	COG3852@1|root,COG4564@1|root,COG3852@2|Bacteria,COG4564@2|Bacteria,1NTTH@1224|Proteobacteria,43BN0@68525|delta/epsilon subdivisions,2X702@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_9,Response_reg,dCache_2
HKD2_k127_7780937_7	1121403.AUCV01000013_gene3961	1.975e-40	153.0	COG1720@1|root,COG1720@2|Bacteria,1MUF0@1224|Proteobacteria,42T7R@68525|delta/epsilon subdivisions,2WPDU@28221|Deltaproteobacteria,2MK9K@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Uncharacterised protein family UPF0066	-	-	-	-	-	-	-	-	-	-	-	-	UPF0066
HKD2_k127_7780937_12	1535422.ND16A_1224	3.825e-08	67.0	COG0484@1|root,COG0484@2|Bacteria,1MXM9@1224|Proteobacteria,1T3FX@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	heat shock protein binding	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C7
HKD2_k127_7780937_8	335543.Sfum_0245	6.723e-26	109.0	COG3357@1|root,COG3357@2|Bacteria,1N7JG@1224|Proteobacteria,42VEP@68525|delta/epsilon subdivisions,2WRD7@28221|Deltaproteobacteria,2MQP0@213462|Syntrophobacterales	28221|Deltaproteobacteria	K	transcriptional regulator containing an HTH domain fused to a Zn-ribbon	-	-	-	ko:K07743	-	-	-	-	ko00000	-	-	-	HTH_5
HKD2_k127_7780937_9	1121405.dsmv_2347	1.98e-22	100.0	COG0515@1|root,COG0664@1|root,COG0515@2|Bacteria,COG0664@2|Bacteria,1MV1P@1224|Proteobacteria,42PPB@68525|delta/epsilon subdivisions,2WJPG@28221|Deltaproteobacteria,2MI4A@213118|Desulfobacterales	28221|Deltaproteobacteria	KLT	Protein tyrosine kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,cNMP_binding
HKD2_k127_7780937_4	439235.Dalk_3926	3.446e-63	243.0	COG0840@1|root,COG4564@1|root,COG0840@2|Bacteria,COG4564@2|Bacteria,1MU9B@1224|Proteobacteria,42KZR@68525|delta/epsilon subdivisions,2WJ2T@28221|Deltaproteobacteria,2MIVQ@213118|Desulfobacterales	28221|Deltaproteobacteria	NT	histidine kinase HAMP region domain protein	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	4HB_MCP_1,HAMP,MCPsignal,dCache_1,dCache_2,sCache_2
HKD2_k127_7780937_10	1220534.B655_1415	7.791e-21	104.0	arCOG02348@1|root,arCOG02348@2157|Archaea,2Y7T3@28890|Euryarchaeota	28890|Euryarchaeota	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c
HKD2_k127_7780937_11	706587.Desti_1768	8.486e-10	70.0	COG4191@1|root,COG4191@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	-	ko:K02660,ko:K11525	ko02020,ko02025,map02020,map02025	-	-	-	ko00000,ko00001,ko02035,ko02044	-	-	-	7TMR-DISMED2,7TMR-DISM_7TM,EAL,GAF,GGDEF,HAMP,MCPsignal,PAS_3,PAS_4,PAS_7,dCache_1
HKD2_k127_7780937_5	589865.DaAHT2_0160	4.088e-56	199.0	COG1974@1|root,COG1974@2|Bacteria,1MZFA@1224|Proteobacteria,42T6V@68525|delta/epsilon subdivisions,2WPNI@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	Belongs to the peptidase S24 family	umuD	-	-	ko:K03503	-	-	-	-	ko00000,ko01000,ko01002,ko03400	-	-	-	Peptidase_S24
HKD2_k127_7780937_0	589865.DaAHT2_0159	1.694e-130	445.0	COG0389@1|root,COG0389@2|Bacteria,1MUUH@1224|Proteobacteria,42NJ4@68525|delta/epsilon subdivisions,2WJXN@28221|Deltaproteobacteria,2MJNN@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Domain of unknown function (DUF4113)	umuC	-	2.7.7.7	ko:K02346,ko:K03502	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DUF4113,IMS,IMS_C,IMS_HHH
HKD2_k127_7780937_13	398512.JQKC01000006_gene619	9.842e-07	59.0	COG1404@1|root,COG1520@1|root,COG1404@2|Bacteria,COG1520@2|Bacteria,1TQ2M@1239|Firmicutes,24CD5@186801|Clostridia,3WRHM@541000|Ruminococcaceae	186801|Clostridia	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	Big_5,Cohesin,Peptidase_S8,SLH
HKD2_k127_778223_0	1203611.KB894548_gene2427	1.452e-90	310.0	COG1882@1|root,COG1882@2|Bacteria,4NDWW@976|Bacteroidetes,2FMC2@200643|Bacteroidia	976|Bacteroidetes	C	Psort location Cytoplasmic, score 9.97	-	-	2.3.1.54	ko:K00656	ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120	-	R00212,R06987	RC00004,RC01181,RC02742,RC02833	ko00000,ko00001,ko01000	-	-	-	Gly_radical,PFL-like
HKD2_k127_778223_1	457424.BFAG_04162	1.868e-64	228.0	COG1180@1|root,COG1180@2|Bacteria,4NIUZ@976|Bacteroidetes,2FP2R@200643|Bacteroidia,4AM94@815|Bacteroidaceae	976|Bacteroidetes	C	4Fe-4S single cluster domain	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4,Fer4_12,Radical_SAM
HKD2_k127_7786310_10	1121403.AUCV01000001_gene880	1.8e-15	76.0	COG0448@1|root,COG0448@2|Bacteria,1MVTC@1224|Proteobacteria,42NGK@68525|delta/epsilon subdivisions,2WM29@28221|Deltaproteobacteria,2MMM3@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Glucose-1-phosphate adenylyltransferase	glgC	-	2.7.7.27	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	M00565	R00948	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2768	NTP_transferase
HKD2_k127_7786310_3	1121403.AUCV01000001_gene879	3.61e-190	602.0	COG0448@1|root,COG0448@2|Bacteria,1MVTC@1224|Proteobacteria,42Y4X@68525|delta/epsilon subdivisions,2WUQC@28221|Deltaproteobacteria,2MPZ6@213118|Desulfobacterales	28221|Deltaproteobacteria	G	Belongs to the bacterial plant glucose-1-phosphate adenylyltransferase family	-	-	2.7.7.27,2.7.7.91	ko:K00975,ko:K20427	ko00500,ko00520,ko00525,ko01100,ko01110,ko01130,ko02026,map00500,map00520,map00525,map01100,map01110,map01130,map02026	M00565,M00814	R00948,R11237,R11246,R11402	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
HKD2_k127_7786310_9	641149.HMPREF9016_01884	3.056e-18	86.0	COG1555@1|root,COG1555@2|Bacteria,1N6Q3@1224|Proteobacteria,2VVT0@28216|Betaproteobacteria	28216|Betaproteobacteria	L	Competence protein	comEA	-	-	ko:K02237	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	HHH_3
HKD2_k127_7786310_0	1121403.AUCV01000009_gene1441	0.0	1230.0	COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,42N8M@68525|delta/epsilon subdivisions,2WJRT@28221|Deltaproteobacteria,2MHZG@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	-	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_lgC,Ribonuc_red_lgN,TSCPD
HKD2_k127_7786310_7	177439.DP2826	1.122e-51	187.0	COG3012@1|root,COG3012@2|Bacteria	2|Bacteria	-	-	CP_0501	-	-	ko:K07039	-	-	-	-	ko00000	-	-	-	HTH_psq,SEC-C
HKD2_k127_7786310_8	177439.DP2825	6.174e-22	106.0	COG5652@1|root,COG5652@2|Bacteria,1NB26@1224|Proteobacteria,42VNM@68525|delta/epsilon subdivisions,2WS4R@28221|Deltaproteobacteria,2MM1X@213118|Desulfobacterales	28221|Deltaproteobacteria	S	VanZ like family	-	-	-	-	-	-	-	-	-	-	-	-	VanZ
HKD2_k127_7786310_4	1167006.UWK_03430	1.282e-179	565.0	COG0113@1|root,COG0113@2|Bacteria,1MWMW@1224|Proteobacteria,42N17@68525|delta/epsilon subdivisions,2WJE8@28221|Deltaproteobacteria,2MI2X@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Belongs to the ALAD family	hemB	-	4.2.1.24	ko:K01698	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00036	RC00918,RC01781	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ALAD
HKD2_k127_7786310_2	1121403.AUCV01000024_gene3407	1.852e-200	632.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WJ88@28221|Deltaproteobacteria,2MI3G@213118|Desulfobacterales	28221|Deltaproteobacteria	T	response regulator receiver	ntrX	-	-	ko:K13599	ko02020,map02020	M00498	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD2_k127_7786310_1	1121403.AUCV01000024_gene3406	2.823e-288	902.0	COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,42MCN@68525|delta/epsilon subdivisions,2WIYA@28221|Deltaproteobacteria,2MHZN@213118|Desulfobacterales	28221|Deltaproteobacteria	T	histidine kinase HAMP region domain protein	ntrY	-	2.7.13.3	ko:K13598	ko02020,map02020	M00498	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4
HKD2_k127_7786310_6	1121403.AUCV01000024_gene3405	1.691e-52	196.0	29GM5@1|root,303IT@2|Bacteria,1RG3T@1224|Proteobacteria,42RUX@68525|delta/epsilon subdivisions,2WNMJ@28221|Deltaproteobacteria,2MJY1@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF4390)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4390
HKD2_k127_7786310_5	926569.ANT_29340	8.903e-105	345.0	COG1088@1|root,COG1088@2|Bacteria,2G5KR@200795|Chloroflexi	200795|Chloroflexi	M	Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily	rmlB	-	4.2.1.46	ko:K01710	ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130	M00793	R06513	RC00402	ko00000,ko00001,ko00002,ko01000	-	-	-	GDP_Man_Dehyd
HKD2_k127_7790974_2	1167006.UWK_03439	1.801e-101	356.0	COG4548@1|root,COG4548@2|Bacteria,1MVBZ@1224|Proteobacteria,42P8Y@68525|delta/epsilon subdivisions,2WJYW@28221|Deltaproteobacteria,2MIZ7@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Von Willebrand factor type A	-	-	-	ko:K02448	-	-	R00294	RC02794	ko00000	3.D.4.10	-	-	VWA
HKD2_k127_7790974_1	1121403.AUCV01000002_gene635	5.249e-130	420.0	COG0714@1|root,COG0714@2|Bacteria,1MXIW@1224|Proteobacteria,42MX4@68525|delta/epsilon subdivisions,2WKVB@28221|Deltaproteobacteria,2MHKN@213118|Desulfobacterales	28221|Deltaproteobacteria	S	ATPase associated with various cellular activities AAA_5	-	-	-	ko:K04748	-	-	R00294	RC02794	ko00000	3.D.4.10	-	-	AAA_5,CbbQ_C
HKD2_k127_7790974_3	1121403.AUCV01000002_gene636	2.57e-86	295.0	COG0613@1|root,COG0613@2|Bacteria,1MWIH@1224|Proteobacteria,42N9R@68525|delta/epsilon subdivisions,2WN5P@28221|Deltaproteobacteria,2MQ3N@213118|Desulfobacterales	28221|Deltaproteobacteria	S	DNA polymerase alpha chain like domain	-	-	3.1.3.97	ko:K07053	-	-	R00188,R11188	RC00078	ko00000,ko01000	-	-	-	PHP
HKD2_k127_7790974_0	1121403.AUCV01000002_gene637	1.325e-239	746.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2MIQF@213118|Desulfobacterales	28221|Deltaproteobacteria	T	response regulator receiver	-	-	-	ko:K02481	-	-	-	-	ko00000,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD2_k127_7792416_0	1232410.KI421426_gene1483	5.518e-52	187.0	29WX2@1|root,30IJ3@2|Bacteria,1Q0W8@1224|Proteobacteria,433PA@68525|delta/epsilon subdivisions,2WXEY@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Cysteine rich repeat	-	-	-	-	-	-	-	-	-	-	-	-	Cys_rich_FGFR
HKD2_k127_7792416_1	387093.SUN_2382	7.557e-48	182.0	COG2067@1|root,COG2067@2|Bacteria,1RJIQ@1224|Proteobacteria	1224|Proteobacteria	I	long-chain fatty acid transport protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7792416_2	237368.SCABRO_03843	1.667e-42	173.0	29D6U@1|root,3004T@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7807799_2	1121403.AUCV01000005_gene318	3.694e-31	126.0	COG2187@1|root,COG2187@2|Bacteria,1MU9M@1224|Proteobacteria,42NEZ@68525|delta/epsilon subdivisions,2WJ5R@28221|Deltaproteobacteria,2MHMS@213118|Desulfobacterales	28221|Deltaproteobacteria	S	AAA domain	-	-	-	ko:K07028	-	-	-	-	ko00000	-	-	-	AAA_33,APH
HKD2_k127_7807799_1	1121403.AUCV01000005_gene317	6.123e-86	295.0	COG1691@1|root,COG1691@2|Bacteria,1REQ7@1224|Proteobacteria,42MJG@68525|delta/epsilon subdivisions,2WN0G@28221|Deltaproteobacteria,2MJ1E@213118|Desulfobacterales	28221|Deltaproteobacteria	S	(AIR) carboxylase	-	-	-	ko:K06898	-	-	-	-	ko00000	-	-	-	AIRC
HKD2_k127_7807799_0	1121403.AUCV01000005_gene315	1e-323	1011.0	COG0341@1|root,COG0342@1|root,COG0341@2|Bacteria,COG0342@2|Bacteria,1MV5U@1224|Proteobacteria,42M6V@68525|delta/epsilon subdivisions,2WJCI@28221|Deltaproteobacteria,2MHS8@213118|Desulfobacterales	28221|Deltaproteobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	-	-	ko:K03072,ko:K12257	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
HKD2_k127_7808929_0	1121403.AUCV01000019_gene3283	0.0	1940.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MXBU@1224|Proteobacteria,42M59@68525|delta/epsilon subdivisions,2WIUK@28221|Deltaproteobacteria,2MICN@213118|Desulfobacterales	28221|Deltaproteobacteria	G	Pyruvate phosphate dikinase, PEP	-	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PPDK_N
HKD2_k127_7847629_2	1379270.AUXF01000001_gene1910	2.494e-67	233.0	COG0179@1|root,COG0179@2|Bacteria,1ZTIG@142182|Gemmatimonadetes	2|Bacteria	Q	Fumarylacetoacetate (FAA) hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	DUF2437,FAA_hydrolase
HKD2_k127_7847629_0	1265505.ATUG01000001_gene3898	8.527e-171	544.0	COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,42MMF@68525|delta/epsilon subdivisions,2WJ1F@28221|Deltaproteobacteria,2MHQX@213118|Desulfobacterales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	-	-	-	ko:K11473	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	CCG,Fer4_8
HKD2_k127_7847629_1	1265505.ATUG01000001_gene3897	2.969e-112	378.0	COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,42YJQ@68525|delta/epsilon subdivisions,2WTJP@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	FAD linked oxidases, C-terminal domain	-	-	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
HKD2_k127_7853058_1	452637.Oter_4432	0.0	1450.0	COG3696@1|root,COG3696@2|Bacteria,46SJ1@74201|Verrucomicrobia,3K7EV@414999|Opitutae	414999|Opitutae	P	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K07787	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4	-	-	ACR_tran
HKD2_k127_7853058_4	1123320.KB889585_gene1769	4.282e-15	81.0	COG1846@1|root,COG1846@2|Bacteria,2IHYF@201174|Actinobacteria	201174|Actinobacteria	K	MarR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_27,MarR,MarR_2
HKD2_k127_7853058_3	243231.GSU2697	2.494e-153	500.0	COG0845@1|root,COG0845@2|Bacteria,1MU78@1224|Proteobacteria,42NHV@68525|delta/epsilon subdivisions,2WJBA@28221|Deltaproteobacteria,43T2U@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	acrA	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	Biotin_lipoyl_2,HlyD,HlyD_3,HlyD_D23
HKD2_k127_7853058_0	316067.Geob_1226	0.0	1723.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJVV@28221|Deltaproteobacteria,43TUU@69541|Desulfuromonadales	28221|Deltaproteobacteria	V	TIGRFAM transporter, hydrophobe amphiphile efflux-1 (HAE1) family	acrB	-	-	ko:K03296,ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
HKD2_k127_7853058_2	269799.Gmet_0811	5.173e-181	580.0	COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,42NKZ@68525|delta/epsilon subdivisions,2WIRB@28221|Deltaproteobacteria,43U7T@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	TIGRFAM RND efflux system, outer membrane lipoprotein, NodT family	-	-	-	ko:K18139	ko01501,ko02024,map01501,map02024	M00642,M00643,M00647,M00718,M00768,M00822	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	1.B.17,2.A.6.2	-	-	OEP
HKD2_k127_7874231_3	926569.ANT_21070	2.249e-37	146.0	COG1695@1|root,COG1695@2|Bacteria,2G7I0@200795|Chloroflexi	200795|Chloroflexi	K	PFAM transcriptional regulator PadR family protein	-	-	-	-	-	-	-	-	-	-	-	-	PadR,Vir_act_alpha_C
HKD2_k127_7874231_1	926569.ANT_16690	2.411e-111	372.0	COG0303@1|root,COG0303@2|Bacteria,2G667@200795|Chloroflexi	200795|Chloroflexi	H	MoeA N-terminal region (domain I and II)	-	-	2.10.1.1	ko:K03750	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N
HKD2_k127_7874231_2	926569.ANT_22470	3.421e-64	227.0	COG0314@1|root,COG1977@1|root,COG0314@2|Bacteria,COG1977@2|Bacteria,2G6YQ@200795|Chloroflexi	200795|Chloroflexi	H	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin	moaD	-	2.8.1.12	ko:K03635,ko:K21142	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09395	RC02507	ko00000,ko00001,ko01000	-	-	-	MoaE,ThiS
HKD2_k127_7874231_0	926569.ANT_25450	5.502e-147	471.0	COG2896@1|root,COG2896@2|Bacteria,2G5JT@200795|Chloroflexi	200795|Chloroflexi	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	-	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Mob_synth_C,Radical_SAM
HKD2_k127_7881728_4	1167006.UWK_03244	3.53e-53	191.0	COG0683@1|root,COG0683@2|Bacteria,1MWJ1@1224|Proteobacteria,42PEN@68525|delta/epsilon subdivisions,2WJ9F@28221|Deltaproteobacteria,2MIQU@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Receptor family ligand binding region	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
HKD2_k127_7881728_2	1167006.UWK_03245	6.398e-91	310.0	COG1663@1|root,COG1663@2|Bacteria,1MU8G@1224|Proteobacteria,42PA2@68525|delta/epsilon subdivisions,2WNJ4@28221|Deltaproteobacteria,2MJ99@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)	lpxK	-	2.7.1.130	ko:K00912	ko00540,ko01100,map00540,map01100	M00060	R04657	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	LpxK
HKD2_k127_7881728_0	1121403.AUCV01000002_gene640	3.537e-137	444.0	COG0774@1|root,COG0774@2|Bacteria,1MV6T@1224|Proteobacteria,42MVM@68525|delta/epsilon subdivisions,2WJ4I@28221|Deltaproteobacteria,2MHWY@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis	lpxC	-	3.5.1.108	ko:K02535,ko:K13599	ko00540,ko01100,ko02020,map00540,map01100,map02020	M00060,M00498	R04587	RC00166,RC00300	ko00000,ko00001,ko00002,ko01000,ko01005,ko02022	-	-	-	LpxC
HKD2_k127_7881728_3	1121403.AUCV01000002_gene639	2.59e-79	273.0	COG0345@1|root,COG0345@2|Bacteria,1R5J1@1224|Proteobacteria,42P7F@68525|delta/epsilon subdivisions,2WJW9@28221|Deltaproteobacteria,2MIK9@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline	proC	-	1.5.1.2	ko:K00286	ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230	M00015	R01248,R01251,R03291,R03293	RC00054,RC00083	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_0899	F420_oxidored,P5CR_dimer
HKD2_k127_7881728_1	1121403.AUCV01000002_gene638	9.377e-107	353.0	COG0061@1|root,COG0061@2|Bacteria,1MUBC@1224|Proteobacteria,42MP8@68525|delta/epsilon subdivisions,2WKMR@28221|Deltaproteobacteria,2MIXA@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	nadK	-	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	NAD_kinase
HKD2_k127_7888376_3	247490.KSU1_C0682	3.355e-42	159.0	COG3189@1|root,COG3189@2|Bacteria,2J0VD@203682|Planctomycetes	203682|Planctomycetes	S	Protein of unknown function, DUF488	-	-	-	-	-	-	-	-	-	-	-	-	DUF488
HKD2_k127_7888376_5	589865.DaAHT2_0203	5.319e-33	131.0	2C492@1|root,346EH@2|Bacteria,1NPYN@1224|Proteobacteria,42XCJ@68525|delta/epsilon subdivisions,2WT7G@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7888376_2	177439.DP1864	5.649e-44	165.0	COG1633@1|root,COG1633@2|Bacteria,1RM4Q@1224|Proteobacteria,42SRM@68525|delta/epsilon subdivisions,2WP47@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Rubrerythrin	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
HKD2_k127_7888376_4	706587.Desti_2735	4.884e-39	153.0	COG1729@1|root,COG4232@1|root,COG1729@2|Bacteria,COG4232@2|Bacteria,1N0AW@1224|Proteobacteria,42TGH@68525|delta/epsilon subdivisions,2WQ33@28221|Deltaproteobacteria,2MRZ1@213462|Syntrophobacterales	28221|Deltaproteobacteria	CO	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_6,Thioredoxin_2,Thioredoxin_7
HKD2_k127_7888376_6	662479.C440_09252	2.845e-19	97.0	COG0589@1|root,arCOG02053@2157|Archaea,2XXYA@28890|Euryarchaeota,23W3S@183963|Halobacteria	183963|Halobacteria	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD2_k127_7888376_1	690850.Desaf_3320	2.704e-54	194.0	COG2033@1|root,COG2033@2|Bacteria,1QNA5@1224|Proteobacteria,435XP@68525|delta/epsilon subdivisions,2X0EC@28221|Deltaproteobacteria,2MC18@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Desulfoferrodoxin	-	-	1.15.1.2	ko:K05919	-	-	-	-	ko00000,ko01000	-	-	-	Desulfoferrodox
HKD2_k127_7888376_0	247490.KSU1_C1035	2.527e-122	401.0	COG0057@1|root,COG0057@2|Bacteria,2IX66@203682|Planctomycetes	2|Bacteria	C	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family	gap	-	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Gp_dh_C,Gp_dh_N
HKD2_k127_7896120_1	443143.GM18_2825	2.311e-09	61.0	COG1366@1|root,COG1366@2|Bacteria,1NK6S@1224|Proteobacteria,42X2N@68525|delta/epsilon subdivisions,2WSS9@28221|Deltaproteobacteria,43ST5@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	STAS domain	-	-	-	-	-	-	-	-	-	-	-	-	STAS_2
HKD2_k127_7896120_0	1265505.ATUG01000001_gene4039	2.364e-40	170.0	COG0840@1|root,COG0840@2|Bacteria,1R8MY@1224|Proteobacteria,42PTU@68525|delta/epsilon subdivisions,2WKCC@28221|Deltaproteobacteria,2MK9N@213118|Desulfobacterales	28221|Deltaproteobacteria	NT	Chemotaxis sensory transducer	mcp34H-1	-	-	-	-	-	-	-	-	-	-	-	MCPsignal,Mut7-C
HKD2_k127_7905750_1	177439.DP1283	1.129e-39	156.0	COG0357@1|root,COG0357@2|Bacteria,1MY0K@1224|Proteobacteria,42SB8@68525|delta/epsilon subdivisions,2WPKF@28221|Deltaproteobacteria,2MJSC@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Specifically methylates the N7 position of guanine in position 527 of 16S rRNA	rsmG	-	2.1.1.170	ko:K03501	-	-	-	-	ko00000,ko01000,ko03009,ko03036	-	-	-	GidB
HKD2_k127_7905750_0	1121403.AUCV01000012_gene4083	1.233e-151	484.0	COG0141@1|root,COG0141@2|Bacteria,1MUUF@1224|Proteobacteria,42M3R@68525|delta/epsilon subdivisions,2WJGT@28221|Deltaproteobacteria,2MICP@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine	hisD	GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.1.1.23	ko:K00013	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01158,R01163,R03012	RC00099,RC00242,RC00463	ko00000,ko00001,ko00002,ko01000	-	-	-	Histidinol_dh
HKD2_k127_7921973_14	1125863.JAFN01000001_gene2338	0.0001078	46.0	COG0602@1|root,COG0602@2|Bacteria,1MUJ2@1224|Proteobacteria,42RT9@68525|delta/epsilon subdivisions,2WNJ0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds	queE	-	4.3.99.3	ko:K10026	ko00790,ko01100,map00790,map01100	-	R10002	RC02989	ko00000,ko00001,ko01000,ko03016	-	-	iAF987.Gmet_1658	Fer4_14,Radical_SAM
HKD2_k127_7921973_1	1121403.AUCV01000002_gene491	1.739e-197	623.0	COG0677@1|root,COG0677@2|Bacteria,1MUC6@1224|Proteobacteria,42M4F@68525|delta/epsilon subdivisions,2WJEW@28221|Deltaproteobacteria,2MHRR@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	capL	-	1.1.1.136	ko:K02474,ko:K13015	ko00520,map00520	-	R00421,R06894	RC00291	ko00000,ko00001,ko01000,ko01005	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
HKD2_k127_7921973_6	1449126.JQKL01000002_gene1657	2.31e-76	269.0	COG2206@1|root,COG2206@2|Bacteria,1UJ0B@1239|Firmicutes,25ESZ@186801|Clostridia	186801|Clostridia	T	SMART Metal-dependent phosphohydrolase, HD region	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HD,HD_5,PAS,PAS_3,PAS_4
HKD2_k127_7921973_4	543913.D521_0650	1.163e-98	341.0	COG2114@1|root,COG2114@2|Bacteria,1PG87@1224|Proteobacteria,2W8ZT@28216|Betaproteobacteria,1KR50@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc
HKD2_k127_7921973_0	1167006.UWK_00491	1.089e-211	680.0	COG1331@1|root,COG1331@2|Bacteria,1MUUT@1224|Proteobacteria,42MP3@68525|delta/epsilon subdivisions,2WJ7Y@28221|Deltaproteobacteria,2MIHW@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Protein of unknown function, DUF255	yyaL	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	GlcNAc_2-epim,Thioredox_DsbH
HKD2_k127_7921973_5	1121403.AUCV01000002_gene488	1.111e-76	260.0	COG0432@1|root,COG0432@2|Bacteria,1RA5G@1224|Proteobacteria,42QZ8@68525|delta/epsilon subdivisions,2WMV9@28221|Deltaproteobacteria,2MJMB@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Uncharacterised protein family UPF0047	-	-	-	-	-	-	-	-	-	-	-	-	UPF0047
HKD2_k127_7921973_9	555779.Dthio_PD2898	7.394e-19	97.0	COG0642@1|root,COG2203@1|root,COG5002@1|root,COG0642@2|Bacteria,COG2203@2|Bacteria,COG2205@2|Bacteria,COG5002@2|Bacteria,1NRP8@1224|Proteobacteria,42M0Y@68525|delta/epsilon subdivisions,2WJCX@28221|Deltaproteobacteria,2MH92@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	PFAM ATP-binding region ATPase domain protein	-	-	2.7.13.3	ko:K07678	ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111	M00475	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	7TMR-DISMED2,7TMR-DISM_7TM,DUF3365,HAMP,HATPase_c,HisKA,Hpt,PAS_4,PAS_9,Response_reg
HKD2_k127_7921973_13	1379281.AVAG01000038_gene766	5.719e-07	61.0	COG2199@1|root,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria	1224|Proteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,HATPase_c,HWE_HK,HisKA,MASE1,PAS,PAS_3,PAS_4,PAS_9,Reg_prop,Response_reg,Y_Y_Y,dCache_1
HKD2_k127_7921973_8	903818.KI912268_gene1035	3.493e-28	118.0	COG0745@1|root,COG0745@2|Bacteria,3Y55U@57723|Acidobacteria	57723|Acidobacteria	T	cheY-homologous receiver domain	-	-	-	ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	Response_reg
HKD2_k127_7921973_10	323850.Shew_0601	2.951e-16	88.0	2E5DY@1|root,3305W@2|Bacteria,1NAMS@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7921973_12	472759.Nhal_2244	2.84e-12	74.0	COG1544@1|root,COG1544@2|Bacteria,1RJ55@1224|Proteobacteria,1S5AA@1236|Gammaproteobacteria,1X0WB@135613|Chromatiales	135613|Chromatiales	J	PFAM Cold-shock protein, DNA-binding	-	-	-	-	-	-	-	-	-	-	-	-	CSD,Ribosomal_S30AE
HKD2_k127_7921973_11	118161.KB235922_gene2388	3.305e-15	82.0	COG1278@1|root,COG1278@2|Bacteria,1G8TJ@1117|Cyanobacteria	1117|Cyanobacteria	K	Sigma 54 modulation protein / S30EA ribosomal protein	-	-	-	-	-	-	-	-	-	-	-	-	CSD,Ribosomal_S30AE
HKD2_k127_7921973_7	1151292.QEW_3813	1.725e-70	249.0	COG0655@1|root,COG0655@2|Bacteria,1V26K@1239|Firmicutes,24G79@186801|Clostridia,25UAP@186804|Peptostreptococcaceae	186801|Clostridia	S	NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
HKD2_k127_7921973_2	443143.GM18_1822	1.588e-196	617.0	COG1064@1|root,COG1064@2|Bacteria,1MUTT@1224|Proteobacteria,42MY6@68525|delta/epsilon subdivisions,2WME2@28221|Deltaproteobacteria,43VHY@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Alcohol dehydrogenase GroES-like domain	mtd	-	-	ko:K13979	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
HKD2_k127_7921973_3	443143.GM18_1819	5.631e-176	556.0	COG0667@1|root,COG0667@2|Bacteria,1MVEH@1224|Proteobacteria,42MDR@68525|delta/epsilon subdivisions,2WKUR@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
HKD2_k127_7953001_7	1121403.AUCV01000014_gene4569	7.743e-136	439.0	COG0330@1|root,COG0330@2|Bacteria,1MV7R@1224|Proteobacteria,42N2V@68525|delta/epsilon subdivisions,2WIPS@28221|Deltaproteobacteria,2MIPC@213118|Desulfobacterales	28221|Deltaproteobacteria	O	HflC and HflK could regulate a protease	hflC	-	-	ko:K04087	-	M00742	-	-	ko00000,ko00002,ko01000	-	-	-	Band_7
HKD2_k127_7953001_13	1167006.UWK_01939	1.818e-85	291.0	COG0352@1|root,COG0352@2|Bacteria,1RDSU@1224|Proteobacteria,42R5Z@68525|delta/epsilon subdivisions,2WMPN@28221|Deltaproteobacteria,2MKY9@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)	thiE	-	2.5.1.3	ko:K00788	ko00730,ko01100,map00730,map01100	M00127	R03223,R10712	RC00224,RC03255,RC03397	ko00000,ko00001,ko00002,ko01000	-	-	-	TMP-TENI
HKD2_k127_7953001_2	1121403.AUCV01000014_gene4567	8.466e-221	690.0	COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,42N8U@68525|delta/epsilon subdivisions,2WJAN@28221|Deltaproteobacteria,2MIT8@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Belongs to the citrate synthase family	gltA	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
HKD2_k127_7953001_11	1142394.PSMK_08370	2.249e-89	307.0	COG1077@1|root,COG1077@2|Bacteria	2|Bacteria	D	Cell shape determining protein MreB Mrl	mreB2	-	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
HKD2_k127_7953001_18	161156.JQKW01000011_gene1030	2.756e-43	173.0	COG0860@1|root,COG1388@1|root,COG0860@2|Bacteria,COG1388@2|Bacteria,2GH8K@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	M	Ami_3	-	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	AMIN,Amidase_3,LysM
HKD2_k127_7953001_22	1121403.AUCV01000014_gene4566	3.34e-15	81.0	COG5581@1|root,COG5581@2|Bacteria,1NK9Q@1224|Proteobacteria,42X4W@68525|delta/epsilon subdivisions,2WT5Y@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	PFAM Type IV pilus assembly PilZ	-	-	-	-	-	-	-	-	-	-	-	-	PilZ
HKD2_k127_7953001_0	1121403.AUCV01000014_gene4565	0.0	1130.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,42NAV@68525|delta/epsilon subdivisions,2WJ3W@28221|Deltaproteobacteria,2MIIB@213118|Desulfobacterales	28221|Deltaproteobacteria	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
HKD2_k127_7953001_16	1121403.AUCV01000014_gene4564	2.429e-70	242.0	COG1278@1|root,COG1278@2|Bacteria,1Q5JD@1224|Proteobacteria,431CZ@68525|delta/epsilon subdivisions,2WWC7@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	'Cold-shock' DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	CSD,Ribosomal_S30AE
HKD2_k127_7953001_8	589865.DaAHT2_1938	4.774e-117	387.0	COG0276@1|root,COG0276@2|Bacteria,1MVR1@1224|Proteobacteria,42M0C@68525|delta/epsilon subdivisions,2WMJ2@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	Catalyzes the ferrous insertion into protoporphyrin IX	hemH	GO:0003674,GO:0003824,GO:0004325,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.99.1.1,4.99.1.9	ko:K01772	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R00310,R11329	RC01012	ko00000,ko00001,ko00002,ko01000	-	-	-	Ferrochelatase
HKD2_k127_7953001_5	1121403.AUCV01000014_gene4562	1.331e-167	534.0	COG0772@1|root,COG0772@2|Bacteria,1MUK3@1224|Proteobacteria,42MQT@68525|delta/epsilon subdivisions,2WIP1@28221|Deltaproteobacteria,2MJ4R@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Peptidoglycan polymerase that is essential for cell wall elongation	mrdB	-	-	ko:K05837	-	-	-	-	ko00000,ko03036	-	-	-	FTSW_RODA_SPOVE
HKD2_k127_7953001_1	1121403.AUCV01000014_gene4561	2.512e-289	900.0	COG0768@1|root,COG0768@2|Bacteria,1MV8C@1224|Proteobacteria,42M1S@68525|delta/epsilon subdivisions,2WJ02@28221|Deltaproteobacteria,2MHV4@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Penicillin-binding Protein dimerisation domain	mrdA	-	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	iAF987.Gmet_0928	PBP_dimer,Transpeptidase
HKD2_k127_7953001_9	1121403.AUCV01000014_gene4559	4.25e-102	339.0	COG1792@1|root,COG1792@2|Bacteria,1N8ZS@1224|Proteobacteria,42S9I@68525|delta/epsilon subdivisions,2WNTW@28221|Deltaproteobacteria,2MJMG@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Involved in formation and maintenance of cell shape	mreC	-	-	ko:K03570	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreC
HKD2_k127_7953001_4	1167006.UWK_01924	1.723e-198	621.0	COG1077@1|root,COG1077@2|Bacteria,1MUMW@1224|Proteobacteria,42M1J@68525|delta/epsilon subdivisions,2WIQR@28221|Deltaproteobacteria,2MIWY@213118|Desulfobacterales	28221|Deltaproteobacteria	D	TIGRFAM cell shape determining protein, MreB Mrl family	mreB	-	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
HKD2_k127_7953001_19	706587.Desti_2074	4.133e-30	124.0	COG0640@1|root,COG0640@2|Bacteria,1NCBM@1224|Proteobacteria,42VFR@68525|delta/epsilon subdivisions,2WRM6@28221|Deltaproteobacteria,2MS6B@213462|Syntrophobacterales	28221|Deltaproteobacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	ko:K22043	-	-	-	-	ko00000,ko03000	-	-	-	HTH_5
HKD2_k127_7953001_21	1121405.dsmv_0260	1.449e-23	102.0	2E36S@1|root,32Y6G@2|Bacteria,1NBSD@1224|Proteobacteria,42VBN@68525|delta/epsilon subdivisions,2WS4J@28221|Deltaproteobacteria,2MPEP@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7953001_23	1121405.dsmv_0264	3.344e-13	72.0	2EBU9@1|root,335TV@2|Bacteria,1NEIU@1224|Proteobacteria,42V7Y@68525|delta/epsilon subdivisions,2WRJ1@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7953001_20	589865.DaAHT2_1610	3.261e-24	103.0	COG1553@1|root,COG1553@2|Bacteria,1NFRH@1224|Proteobacteria,42XP5@68525|delta/epsilon subdivisions,2WT3T@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	manually curated	-	-	-	ko:K06039	-	-	-	-	ko00000	-	-	-	DrsE
HKD2_k127_7953001_24	589865.DaAHT2_1610	1.301e-10	61.0	COG1553@1|root,COG1553@2|Bacteria,1NFRH@1224|Proteobacteria,42XP5@68525|delta/epsilon subdivisions,2WT3T@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	manually curated	-	-	-	ko:K06039	-	-	-	-	ko00000	-	-	-	DrsE
HKD2_k127_7953001_6	589865.DaAHT2_2661	2.037e-165	529.0	COG0446@1|root,COG0446@2|Bacteria,1QSGB@1224|Proteobacteria,43A36@68525|delta/epsilon subdivisions,2WZXC@28221|Deltaproteobacteria,2MP72@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.5.4	ko:K17218	ko00920,map00920	-	R10152	RC03155	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
HKD2_k127_7953001_14	644966.Tmar_0255	1.933e-79	273.0	COG0730@1|root,COG0730@2|Bacteria,1TRIE@1239|Firmicutes	1239|Firmicutes	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
HKD2_k127_7953001_10	1207063.P24_18112	4.458e-101	352.0	COG3000@1|root,COG3000@2|Bacteria,1MW5G@1224|Proteobacteria,2TU63@28211|Alphaproteobacteria,2JSD0@204441|Rhodospirillales	204441|Rhodospirillales	I	Fatty acid hydroxylase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	FA_hydroxylase
HKD2_k127_7953001_3	1123242.JH636435_gene2223	5.368e-220	716.0	COG1520@1|root,COG3391@1|root,COG1520@2|Bacteria,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF4114
HKD2_k127_7953001_12	1167006.UWK_00887	1.404e-86	291.0	COG0226@1|root,COG0226@2|Bacteria,1MUH9@1224|Proteobacteria,42MJ3@68525|delta/epsilon subdivisions,2WKD5@28221|Deltaproteobacteria,2MHQC@213118|Desulfobacterales	28221|Deltaproteobacteria	P	PBP superfamily domain	-	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
HKD2_k127_7984126_1	1167006.UWK_03173	8.291e-153	487.0	COG0039@1|root,COG0039@2|Bacteria,1MV57@1224|Proteobacteria,42KZJ@68525|delta/epsilon subdivisions,2WJ4U@28221|Deltaproteobacteria,2MJ7T@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Catalyzes the reversible oxidation of malate to oxaloacetate	mdh	GO:0003674,GO:0003824,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016491,GO:0016614,GO:0016615,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0055114,GO:0071704,GO:0072350	1.1.1.37	ko:K00024	ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740	R00342,R07136	RC00031	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_1360	Ldh_1_C,Ldh_1_N
HKD2_k127_7984126_3	161156.JQKW01000006_gene1384	1.297e-31	131.0	COG1212@1|root,COG1212@2|Bacteria,2GGVZ@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	M	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria	kdsB	-	2.7.7.38	ko:K00979	ko00540,ko01100,map00540,map01100	M00063	R03351,R11396	RC00152,RC00910	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CTP_transf_3
HKD2_k127_7984126_2	1167006.UWK_03174	1.28e-59	209.0	COG1212@1|root,COG1212@2|Bacteria,1MUUU@1224|Proteobacteria,42PTX@68525|delta/epsilon subdivisions,2WMQW@28221|Deltaproteobacteria,2MJFA@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria	kdsB	-	2.7.7.38	ko:K00979	ko00540,ko01100,map00540,map01100	M00063	R03351,R11396	RC00152,RC00910	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CTP_transf_3
HKD2_k127_7984126_0	335543.Sfum_0086	2.292e-191	615.0	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,42M01@68525|delta/epsilon subdivisions,2WJ7M@28221|Deltaproteobacteria,2MQ69@213462|Syntrophobacterales	28221|Deltaproteobacteria	V	Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran,Peptidase_C39
HKD2_k127_801415_13	1123392.AQWL01000001_gene1367	1.65e-36	148.0	COG0421@1|root,COG0421@2|Bacteria,1RBWW@1224|Proteobacteria,2VT0X@28216|Betaproteobacteria,1KSZ1@119069|Hydrogenophilales	119069|Hydrogenophilales	E	Spermine/spermidine synthase domain	-	-	-	-	-	-	-	-	-	-	-	-	Spermine_synth
HKD2_k127_801415_9	1265505.ATUG01000002_gene1466	2.638e-73	261.0	2CB8R@1|root,2Z90U@2|Bacteria,1R4DV@1224|Proteobacteria,42R2G@68525|delta/epsilon subdivisions,2WMQS@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_801415_6	522306.CAP2UW1_3649	1.229e-97	334.0	COG2199@1|root,COG3706@2|Bacteria	2|Bacteria	T	GGDEF domain	-	-	2.7.7.65	ko:K13069	-	-	R08057	-	ko00000,ko01000	-	-	-	GGDEF,HAMP
HKD2_k127_801415_2	243231.GSU0213	2.544e-186	596.0	COG1032@1|root,COG1032@2|Bacteria,1PDZR@1224|Proteobacteria,42M73@68525|delta/epsilon subdivisions,2WK6Y@28221|Deltaproteobacteria,43SAZ@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
HKD2_k127_801415_15	1232410.KI421420_gene3193	2.121e-16	80.0	2ES4N@1|root,31TTP@2|Bacteria,1QRKN@1224|Proteobacteria,437DZ@68525|delta/epsilon subdivisions,2X2K4@28221|Deltaproteobacteria,43VUC@69541|Desulfuromonadales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_801415_1	56780.SYN_02584	4.604e-295	915.0	COG0514@1|root,COG0514@2|Bacteria,1MVGG@1224|Proteobacteria,42MV3@68525|delta/epsilon subdivisions,2WJZB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	ATP-dependent DNA helicase RecQ	recQ	-	3.6.4.12	ko:K03654	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,HRDC,HTH_40,Helicase_C,RQC,RecQ_Zn_bind
HKD2_k127_801415_3	1121918.ARWE01000001_gene2821	3.33e-173	565.0	COG0842@1|root,COG0842@2|Bacteria,1MW5R@1224|Proteobacteria,42N83@68525|delta/epsilon subdivisions,2WJFF@28221|Deltaproteobacteria,43T0V@69541|Desulfuromonadales	28221|Deltaproteobacteria	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
HKD2_k127_801415_4	1121918.ARWE01000001_gene2820	5.628e-140	451.0	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,42MV1@68525|delta/epsilon subdivisions,2WK9W@28221|Deltaproteobacteria,43T91@69541|Desulfuromonadales	28221|Deltaproteobacteria	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD2_k127_801415_7	1121440.AUMA01000010_gene503	2.572e-92	314.0	COG1566@1|root,COG1566@2|Bacteria,1QUDS@1224|Proteobacteria,42QZG@68525|delta/epsilon subdivisions,2WN4C@28221|Deltaproteobacteria,2M8IJ@213115|Desulfovibrionales	28221|Deltaproteobacteria	V	HlyD family secretion protein	-	-	-	ko:K01993	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_3
HKD2_k127_801415_12	913865.DOT_6248	8.97e-38	151.0	COG5561@1|root,COG5561@2|Bacteria,1VJ0D@1239|Firmicutes,24RTC@186801|Clostridia,265JS@186807|Peptococcaceae	186801|Clostridia	S	CGGC	-	-	-	-	-	-	-	-	-	-	-	-	CGGC
HKD2_k127_801415_11	398512.JQKC01000016_gene2747	6.49e-46	179.0	COG2199@1|root,COG3706@2|Bacteria,1V9Y7@1239|Firmicutes,24A8B@186801|Clostridia	186801|Clostridia	T	TIGRFAM Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
HKD2_k127_801415_0	1121403.AUCV01000014_gene4579	0.0	1114.0	COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,42N22@68525|delta/epsilon subdivisions,2WIMH@28221|Deltaproteobacteria,2MJ0S@213118|Desulfobacterales	28221|Deltaproteobacteria	G	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties	glgP	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	Phosphorylase
HKD2_k127_801415_5	879212.DespoDRAFT_03506	7.597e-103	346.0	COG1858@1|root,COG1858@2|Bacteria,1MV70@1224|Proteobacteria,42N38@68525|delta/epsilon subdivisions,2WK56@28221|Deltaproteobacteria,2MHP9@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Di-haem cytochrome c peroxidase	-	-	-	-	-	-	-	-	-	-	-	-	CCP_MauG,Cytochrom_C
HKD2_k127_801415_8	1121035.AUCH01000005_gene1	2.192e-78	272.0	COG2234@1|root,COG2234@2|Bacteria,1MXZS@1224|Proteobacteria	1224|Proteobacteria	S	PFAM peptidase M28	yfbL	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
HKD2_k127_801415_10	402881.Plav_1288	4.83e-54	202.0	COG0457@1|root,COG0457@2|Bacteria,1NG0U@1224|Proteobacteria,2U0YA@28211|Alphaproteobacteria,1JNV7@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_11,TPR_2,TPR_8
HKD2_k127_803607_2	1121035.AUCH01000012_gene2935	2.23e-06	53.0	COG4987@1|root,COG4987@2|Bacteria,1QU1P@1224|Proteobacteria,2VM7V@28216|Betaproteobacteria	28216|Betaproteobacteria	CO	TIGRFAM ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC	cydC	-	-	ko:K16012	ko02010,map02010	-	-	-	ko00000,ko00001,ko02000	3.A.1.129	-	-	ABC_membrane,ABC_tran
HKD2_k127_803607_0	1121405.dsmv_2062	1.995e-198	634.0	COG4988@1|root,COG4988@2|Bacteria,1QU1N@1224|Proteobacteria,42MNK@68525|delta/epsilon subdivisions,2WM0W@28221|Deltaproteobacteria,2MN5X@213118|Desulfobacterales	28221|Deltaproteobacteria	CO	TIGRFAM ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydD	cydD	-	-	ko:K16013	ko02010,map02010	-	-	-	ko00000,ko00001,ko02000	3.A.1.129	-	-	ABC_membrane,ABC_tran
HKD2_k127_803607_1	572477.Alvin_2499	7.173e-25	104.0	COG1271@1|root,COG1271@2|Bacteria,1MV60@1224|Proteobacteria,1RN2U@1236|Gammaproteobacteria,1WXGE@135613|Chromatiales	135613|Chromatiales	C	PFAM Cytochrome bd ubiquinol oxidase, subunit I	-	-	1.10.3.14	ko:K00425	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	Cyt_bd_oxida_I
HKD2_k127_8066854_1	1121406.JAEX01000002_gene788	1.497e-61	213.0	COG2710@1|root,COG2710@2|Bacteria,1MWQ4@1224|Proteobacteria,42MNG@68525|delta/epsilon subdivisions,2WIWX@28221|Deltaproteobacteria,2M8N7@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation	nifK	-	1.18.6.1	ko:K02591	ko00625,ko00910,ko01100,ko01120,map00625,map00910,map01100,map01120	M00175	R05185,R05496	RC00002,RC01395,RC02891	ko00000,ko00001,ko00002,ko01000	-	-	-	Oxidored_nitro
HKD2_k127_8066854_0	643562.Daes_1026	9.057e-94	323.0	COG0535@1|root,COG0535@2|Bacteria,1RF7F@1224|Proteobacteria,42S6X@68525|delta/epsilon subdivisions,2WNPC@28221|Deltaproteobacteria,2M9RJ@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	PFAM Dinitrogenase iron-molybdenum cofactor biosynthesis	-	-	-	ko:K02585	-	-	-	-	ko00000	-	-	-	Nitro_FeMo-Co,Radical_SAM
HKD2_k127_8066854_2	589865.DaAHT2_2460	1.462e-51	183.0	COG3411@1|root,COG3411@2|Bacteria,1RM68@1224|Proteobacteria,42TUK@68525|delta/epsilon subdivisions,2WQGU@28221|Deltaproteobacteria,2MK49@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Ferredoxin	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8066854_3	1121456.ATVA01000015_gene2305	3.19e-43	167.0	COG0454@1|root,COG0456@2|Bacteria,1N2EC@1224|Proteobacteria,42TNE@68525|delta/epsilon subdivisions,2WQI7@28221|Deltaproteobacteria,2MCG3@213115|Desulfovibrionales	28221|Deltaproteobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HKD2_k127_8066854_4	290315.Clim_1649	2.829e-27	113.0	2DNFB@1|root,32X7Q@2|Bacteria,1FE3W@1090|Chlorobi	1090|Chlorobi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8066854_5	1167006.UWK_00343	2.415e-23	105.0	2EJZ1@1|root,33DPM@2|Bacteria,1QS6H@1224|Proteobacteria,42Y23@68525|delta/epsilon subdivisions,2WT02@28221|Deltaproteobacteria,2MMDU@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8081097_1	335543.Sfum_1614	8.933e-70	239.0	COG3825@1|root,COG3825@2|Bacteria,1MUAJ@1224|Proteobacteria,42N7R@68525|delta/epsilon subdivisions,2WJBI@28221|Deltaproteobacteria,2MR3A@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	VWA containing CoxE family protein	-	-	-	ko:K09989	-	-	-	-	ko00000	-	-	-	VWA_CoxE
HKD2_k127_8081097_0	335543.Sfum_1615	6.535e-157	501.0	COG0714@1|root,COG0714@2|Bacteria,1MV5I@1224|Proteobacteria,42MTW@68525|delta/epsilon subdivisions,2WJ0J@28221|Deltaproteobacteria,2MRC6@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	AAA domain (Cdc48 subfamily)	-	-	-	-	-	-	-	-	-	-	-	-	AAA,AAA_5
HKD2_k127_8083893_0	192952.MM_1377	1.542e-76	275.0	COG5607@1|root,arCOG05139@2157|Archaea,2Y7EP@28890|Euryarchaeota,2NA8G@224756|Methanomicrobia	224756|Methanomicrobia	F	CHAD	-	-	-	-	-	-	-	-	-	-	-	-	CHAD,CYTH
HKD2_k127_8103156_21	1121403.AUCV01000050_gene2116	8.03e-07	51.0	COG1085@1|root,COG1085@2|Bacteria,1R6SM@1224|Proteobacteria,42QFF@68525|delta/epsilon subdivisions,2WKFN@28221|Deltaproteobacteria,2MIE7@213118|Desulfobacterales	28221|Deltaproteobacteria	C	galactose-1-phosphate uridylyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8103156_1	1121403.AUCV01000050_gene2117	4.616e-221	694.0	COG0133@1|root,COG0133@2|Bacteria,1MUS8@1224|Proteobacteria,42MIA@68525|delta/epsilon subdivisions,2WJJA@28221|Deltaproteobacteria,2MHP8@213118|Desulfobacterales	28221|Deltaproteobacteria	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB	-	4.2.1.20	ko:K01696	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HKD2_k127_8103156_8	1121403.AUCV01000050_gene2118	1.275e-104	345.0	COG0159@1|root,COG0159@2|Bacteria,1MXJV@1224|Proteobacteria,42N5B@68525|delta/epsilon subdivisions,2WJX4@28221|Deltaproteobacteria,2MIHZ@213118|Desulfobacterales	28221|Deltaproteobacteria	E	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate	trpA	-	4.2.1.20	ko:K01695	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_syntA
HKD2_k127_8103156_19	1121403.AUCV01000008_gene1579	4.237e-19	91.0	COG1918@1|root,COG1918@2|Bacteria	2|Bacteria	P	iron ion homeostasis	-	-	-	ko:K04758	-	-	-	-	ko00000,ko02000	-	-	-	FeoA
HKD2_k127_8103156_0	1121403.AUCV01000008_gene1576	0.0	1031.0	COG0370@1|root,COG0370@2|Bacteria,1MUZC@1224|Proteobacteria,42MCY@68525|delta/epsilon subdivisions,2WIWJ@28221|Deltaproteobacteria,2MIW3@213118|Desulfobacterales	28221|Deltaproteobacteria	P	transporter of a GTP-driven Fe(2 ) uptake system	feoB	-	-	ko:K04759	-	-	-	-	ko00000,ko02000	9.A.8.1	-	-	FeoB_C,FeoB_N,Gate
HKD2_k127_8103156_3	1121033.AUCF01000011_gene1817	2.444e-160	512.0	COG0182@1|root,COG0182@2|Bacteria,1MUPM@1224|Proteobacteria,2TSPP@28211|Alphaproteobacteria,2JQQJ@204441|Rhodospirillales	204441|Rhodospirillales	E	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)	mtnA	-	5.3.1.23	ko:K08963	ko00270,ko01100,map00270,map01100	M00034	R04420	RC01151	ko00000,ko00001,ko00002,ko01000	-	-	-	IF-2B
HKD2_k127_8103156_11	589865.DaAHT2_0415	9.794e-79	275.0	COG2984@1|root,COG2984@2|Bacteria	2|Bacteria	S	ABC transporter substrate binding protein	CP_0258	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
HKD2_k127_8103156_2	589865.DaAHT2_2564	9.224e-202	663.0	COG0784@1|root,COG5000@1|root,COG5002@1|root,COG0784@2|Bacteria,COG5000@2|Bacteria,COG5002@2|Bacteria,1NC9X@1224|Proteobacteria,43BSJ@68525|delta/epsilon subdivisions,2X73B@28221|Deltaproteobacteria,2MI6A@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_9,Response_reg
HKD2_k127_8103156_5	1167006.UWK_02338	1.546e-155	511.0	COG0616@1|root,COG0616@2|Bacteria,1MUXE@1224|Proteobacteria,42R62@68525|delta/epsilon subdivisions,2WN5J@28221|Deltaproteobacteria,2MPT0@213118|Desulfobacterales	28221|Deltaproteobacteria	OU	Peptidase family S49	-	-	-	ko:K04773	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S49
HKD2_k127_8103156_4	1232437.KL661986_gene3681	1.36e-157	509.0	COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,42MGZ@68525|delta/epsilon subdivisions,2WIY6@28221|Deltaproteobacteria,2MHSV@213118|Desulfobacterales	28221|Deltaproteobacteria	L	DEAD DEAH box helicase	rhlE-2	-	3.6.4.13	ko:K11927	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DEAD,Helicase_C
HKD2_k127_8103156_17	765910.MARPU_14015	1.629e-29	119.0	COG0724@1|root,COG0724@2|Bacteria,1N6VR@1224|Proteobacteria,1SCKA@1236|Gammaproteobacteria,1WYKM@135613|Chromatiales	135613|Chromatiales	S	RNA-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	RRM_1
HKD2_k127_8103156_6	237368.SCABRO_01298	3.324e-116	388.0	COG0513@1|root,COG0513@2|Bacteria,2IX02@203682|Planctomycetes	2|Bacteria	JKL	DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation	dedA	-	3.6.4.13	ko:K05592	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019	-	-	-	DEAD,DbpA,Helicase_C
HKD2_k127_8103156_16	644968.DFW101_2755	1.837e-30	126.0	COG1186@1|root,COG1186@2|Bacteria,1RH75@1224|Proteobacteria,42VTR@68525|delta/epsilon subdivisions,2X5PP@28221|Deltaproteobacteria,2MGU1@213115|Desulfovibrionales	28221|Deltaproteobacteria	J	chain release factor	-	-	-	ko:K15034	-	-	-	-	ko00000,ko03012	-	-	-	RF-1
HKD2_k127_8103156_18	194439.CT0188	1.344e-20	94.0	COG1858@1|root,COG1858@2|Bacteria,1FFAV@1090|Chlorobi	1090|Chlorobi	C	cytochrome C peroxidase	-	-	-	-	-	-	-	-	-	-	-	-	CCP_MauG
HKD2_k127_8103156_14	1123326.JFBL01000006_gene928	9.808e-33	134.0	COG0727@1|root,COG0727@2|Bacteria,1N3F5@1224|Proteobacteria,42THI@68525|delta/epsilon subdivisions,2YPYY@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	S	Uncharacterised protein family (UPF0153)	-	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
HKD2_k127_8103156_9	768671.ThimaDRAFT_0187	8.697e-102	344.0	COG0767@1|root,COG0767@2|Bacteria,1MVPN@1224|Proteobacteria,1RYHN@1236|Gammaproteobacteria,1WXIV@135613|Chromatiales	135613|Chromatiales	Q	Permease MlaE	-	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE,STAS_2
HKD2_k127_8103156_7	335543.Sfum_2415	7.732e-110	359.0	COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,42NTG@68525|delta/epsilon subdivisions,2WKHW@28221|Deltaproteobacteria,2MQ9V@213462|Syntrophobacterales	28221|Deltaproteobacteria	Q	ABC-type transport system involved in resistance to organic solvents, ATPase component	-	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
HKD2_k127_8103156_13	1286631.X805_02180	2.764e-58	219.0	COG1463@1|root,COG1463@2|Bacteria,1QWAA@1224|Proteobacteria,2WHQ2@28216|Betaproteobacteria,1KJKU@119065|unclassified Burkholderiales	28216|Betaproteobacteria	Q	MlaD protein	-	-	-	ko:K06192	-	-	-	-	ko00000	-	-	-	MlaD
HKD2_k127_8103156_15	243233.MCA0364	1.013e-32	136.0	COG3009@1|root,COG3009@2|Bacteria,1N8BW@1224|Proteobacteria,1SHZZ@1236|Gammaproteobacteria,1XF9Y@135618|Methylococcales	135618|Methylococcales	S	ABC-type transport auxiliary lipoprotein component	-	-	-	ko:K09857	-	-	-	-	ko00000	-	-	-	ABC_trans_aux
HKD2_k127_8103156_12	1249627.D779_3710	2.448e-66	236.0	COG1451@1|root,COG1451@2|Bacteria,1MXZU@1224|Proteobacteria,1S9E4@1236|Gammaproteobacteria,1WZ4X@135613|Chromatiales	135613|Chromatiales	S	Protein of unknown function DUF45	-	-	-	ko:K07043	-	-	-	-	ko00000	-	-	-	DUF45
HKD2_k127_8103156_10	335543.Sfum_0688	1.555e-86	304.0	COG2206@1|root,COG2206@2|Bacteria,1N5T4@1224|Proteobacteria,43AMJ@68525|delta/epsilon subdivisions,2X61J@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	SMART Metal-dependent phosphohydrolase, HD region	-	-	-	-	-	-	-	-	-	-	-	-	DUF3391,HD,HD_5
HKD2_k127_8128646_3	331678.Cphamn1_0813	9.402e-75	258.0	28Z54@1|root,2ZKXF@2|Bacteria,1FF0Y@1090|Chlorobi	1090|Chlorobi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8128646_1	1121403.AUCV01000021_gene3571	6.401e-161	522.0	COG0501@1|root,COG0501@2|Bacteria,1MUXT@1224|Proteobacteria,42P1M@68525|delta/epsilon subdivisions,2WKJ2@28221|Deltaproteobacteria,2MJ05@213118|Desulfobacterales	28221|Deltaproteobacteria	O	CAAX prenyl protease N-terminal, five membrane helices	-	-	3.4.24.84	ko:K06013	ko00900,ko01130,map00900,map01130	-	R09845	RC00141	ko00000,ko00001,ko01000,ko01002,ko04147	-	-	-	Peptidase_M48,Peptidase_M48_N
HKD2_k127_8128646_2	1499967.BAYZ01000080_gene931	1.317e-146	491.0	COG3291@1|root,COG3291@2|Bacteria	2|Bacteria	S	metallopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	PKD,SBBP
HKD2_k127_8128646_4	1167006.UWK_02366	2.273e-57	207.0	COG0110@1|root,COG0110@2|Bacteria,1MUCJ@1224|Proteobacteria,42VP2@68525|delta/epsilon subdivisions,2WRZQ@28221|Deltaproteobacteria,2MKVA@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Bacterial transferase hexapeptide (six repeats)	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep
HKD2_k127_8128646_0	1167006.UWK_00907	3.467e-226	716.0	COG1835@1|root,COG1835@2|Bacteria,1MV2W@1224|Proteobacteria,42R7N@68525|delta/epsilon subdivisions,2WNTG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	PFAM Acyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
HKD2_k127_816566_2	1121033.AUCF01000017_gene3889	2.69e-35	157.0	COG1404@1|root,COG2931@1|root,COG4733@1|root,COG1404@2|Bacteria,COG2931@2|Bacteria,COG4733@2|Bacteria,1Q0R4@1224|Proteobacteria,2V8X6@28211|Alphaproteobacteria,2JWZH@204441|Rhodospirillales	204441|Rhodospirillales	Q	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_816566_3	166318.Syn8016DRAFT_2966	9.927e-30	130.0	2C96H@1|root,2Z7Q6@2|Bacteria,1G46E@1117|Cyanobacteria,1H2JU@1129|Synechococcus	1117|Cyanobacteria	S	Sulfotransferase domain	-	-	-	ko:K13472	ko04626,map04626	-	-	-	ko00000,ko00001	-	-	-	Sulfotransfer_3
HKD2_k127_816566_1	335543.Sfum_0687	1.141e-37	161.0	COG1413@1|root,COG1413@2|Bacteria,1P1H4@1224|Proteobacteria,431VX@68525|delta/epsilon subdivisions,2WWU3@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_816566_0	335543.Sfum_0688	1.295e-96	336.0	COG2206@1|root,COG2206@2|Bacteria,1N5T4@1224|Proteobacteria,43AMJ@68525|delta/epsilon subdivisions,2X61J@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	SMART Metal-dependent phosphohydrolase, HD region	-	-	-	-	-	-	-	-	-	-	-	-	DUF3391,HD,HD_5
HKD2_k127_816566_4	1209989.TepiRe1_0612	1.625e-07	61.0	COG1410@1|root,COG1410@2|Bacteria,1UXXG@1239|Firmicutes,24D45@186801|Clostridia,42FXQ@68295|Thermoanaerobacterales	186801|Clostridia	E	Pterin binding enzyme	acsE	-	2.1.1.258	ko:K15023	ko00720,ko01120,ko01200,map00720,map01120,map01200	M00377	R02289,R10243	RC00004,RC00113,RC01144,RC02871,RC02977	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
HKD2_k127_8175580_0	1121403.AUCV01000008_gene1534	1.925e-97	326.0	COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,42N87@68525|delta/epsilon subdivisions,2WK1B@28221|Deltaproteobacteria,2MHU5@213118|Desulfobacterales	28221|Deltaproteobacteria	S	pfam abc-1	-	-	-	ko:K03688	-	-	-	-	ko00000	-	-	-	ABC1,APH
HKD2_k127_8175580_5	1121403.AUCV01000008_gene1533	5.536e-21	96.0	COG3937@1|root,COG3937@2|Bacteria,1NM7V@1224|Proteobacteria,42WSS@68525|delta/epsilon subdivisions	1224|Proteobacteria	S	granule-associated protein	-	-	-	-	-	-	-	-	-	-	-	-	Phasin
HKD2_k127_8175580_3	1121403.AUCV01000008_gene1532	7.625e-36	139.0	COG1660@1|root,COG1660@2|Bacteria,1MVX6@1224|Proteobacteria,42MZM@68525|delta/epsilon subdivisions,2WJG6@28221|Deltaproteobacteria,2MJ01@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Displays ATPase and GTPase activities	-	-	-	ko:K06958	-	-	-	-	ko00000,ko03019	-	-	-	ATP_bind_2
HKD2_k127_8175580_2	1167006.UWK_02244	2.925e-52	192.0	COG0716@1|root,COG0716@2|Bacteria,1RJCS@1224|Proteobacteria,42RVT@68525|delta/epsilon subdivisions,2WPKG@28221|Deltaproteobacteria,2MKYP@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Flavodoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_3
HKD2_k127_8175580_4	511062.GU3_00430	2.152e-25	114.0	2E4SV@1|root,32ZM7@2|Bacteria,1N8VN@1224|Proteobacteria,1S6AW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Putative transmembrane protein (PGPGW)	-	-	-	-	-	-	-	-	-	-	-	-	PGPGW
HKD2_k127_8175580_1	1167006.UWK_02246	2.474e-91	311.0	COG2264@1|root,COG2264@2|Bacteria,1MUPC@1224|Proteobacteria,42QGK@68525|delta/epsilon subdivisions,2WMC7@28221|Deltaproteobacteria,2MHPR@213118|Desulfobacterales	28221|Deltaproteobacteria	J	L11 methyltransferase	-	-	-	ko:K02687	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PrmA
HKD2_k127_8175580_6	1415754.JQMK01000002_gene1967	0.0001963	53.0	COG2911@1|root,COG2911@2|Bacteria,1QWGG@1224|Proteobacteria,1T3BE@1236|Gammaproteobacteria,46D4Z@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Domain of Unknown Function (DUF748)	-	-	-	-	-	-	-	-	-	-	-	-	DUF748,OmpA
HKD2_k127_8177168_0	589865.DaAHT2_1972	1.146e-128	423.0	COG1032@1|root,COG1032@2|Bacteria,1Q5NG@1224|Proteobacteria,42N2D@68525|delta/epsilon subdivisions,2WUXJ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	radical SAM	-	-	1.21.98.3	ko:K04034	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R06268,R06269,R06270	RC00741,RC01491,RC01492	ko00000,ko00001,ko01000	-	-	-	DUF4080,Radical_SAM
HKD2_k127_8177168_1	1056512.D515_01893	8.496e-45	170.0	COG0517@1|root,COG0517@2|Bacteria,1RA25@1224|Proteobacteria,1SH2H@1236|Gammaproteobacteria,1XXXJ@135623|Vibrionales	135623|Vibrionales	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	ko:K04767	-	-	-	-	ko00000	-	-	-	CBS
HKD2_k127_8177168_2	1167006.UWK_01176	5.532e-09	59.0	COG2334@1|root,COG2334@2|Bacteria,1MU2Q@1224|Proteobacteria,42QEX@68525|delta/epsilon subdivisions,2WMFU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	F	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response	srkA	-	-	-	-	-	-	-	-	-	-	-	APH
HKD2_k127_8220983_0	1121403.AUCV01000005_gene315	6.902e-189	601.0	COG0341@1|root,COG0342@1|root,COG0341@2|Bacteria,COG0342@2|Bacteria,1MV5U@1224|Proteobacteria,42M6V@68525|delta/epsilon subdivisions,2WJCI@28221|Deltaproteobacteria,2MHS8@213118|Desulfobacterales	28221|Deltaproteobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	-	-	ko:K03072,ko:K12257	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
HKD2_k127_8220983_1	1121403.AUCV01000005_gene314	7.458e-105	345.0	COG0727@1|root,COG0727@2|Bacteria,1RCRP@1224|Proteobacteria,42QP5@68525|delta/epsilon subdivisions,2WMQD@28221|Deltaproteobacteria,2MJI3@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Putative zinc- or iron-chelating domain	-	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
HKD2_k127_8220983_2	1121403.AUCV01000005_gene313	1.501e-79	273.0	COG1418@1|root,COG1418@2|Bacteria,1RB2W@1224|Proteobacteria,42RBY@68525|delta/epsilon subdivisions,2WN17@28221|Deltaproteobacteria,2MJPD@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	ko:K06950	-	-	-	-	ko00000	-	-	-	HD
HKD2_k127_8220983_3	1121403.AUCV01000005_gene312	8.292e-37	141.0	COG0546@1|root,COG0546@2|Bacteria,1MY9Y@1224|Proteobacteria,42SSC@68525|delta/epsilon subdivisions,2WN7Q@28221|Deltaproteobacteria,2MKDC@213118|Desulfobacterales	28221|Deltaproteobacteria	S	haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E	-	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
HKD2_k127_8227114_1	1121472.AQWN01000006_gene1834	5.563e-69	241.0	COG1143@1|root,COG1143@2|Bacteria,1UJ43@1239|Firmicutes,25EVE@186801|Clostridia,2605I@186807|Peptococcaceae	186801|Clostridia	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	asrA	-	-	ko:K16950	ko00920,ko01120,map00920,map01120	-	R00858,R10146	RC00065	ko00000,ko00001	-	-	-	Fer4_22
HKD2_k127_8227114_0	644282.Deba_2136	3.989e-112	367.0	COG0543@1|root,COG0543@2|Bacteria,1R6QZ@1224|Proteobacteria,42MVW@68525|delta/epsilon subdivisions,2WKKC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM oxidoreductase FAD NAD(P)-binding domain protein	hdrF	-	-	-	-	-	-	-	-	-	-	-	DHODB_Fe-S_bind,FAD_binding_6,NAD_binding_1
HKD2_k127_8307074_1	1121403.AUCV01000006_gene404	2.985e-127	412.0	COG0260@1|root,COG0260@2|Bacteria,1MUF9@1224|Proteobacteria,42M2G@68525|delta/epsilon subdivisions,2WJ80@28221|Deltaproteobacteria,2MIFW@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	pepA	-	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17,Peptidase_M17_N
HKD2_k127_8307074_0	589865.DaAHT2_0468	1.188e-152	488.0	COG0158@1|root,COG0158@2|Bacteria,1MW0E@1224|Proteobacteria,42NRA@68525|delta/epsilon subdivisions,2WJ62@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1	fbp	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005984,GO:0005985,GO:0005986,GO:0005996,GO:0006000,GO:0006002,GO:0006006,GO:0006094,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0019318,GO:0019319,GO:0019637,GO:0030388,GO:0034637,GO:0042132,GO:0042578,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0046364,GO:0050308,GO:0071704,GO:1901135,GO:1901576	3.1.3.11	ko:K03841	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko04152,ko04910,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map04152,map04910	M00003,M00165,M00167,M00344	R00762,R04780	RC00017	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	FBPase
HKD2_k127_8348190_0	1121403.AUCV01000013_gene3907	7.579e-154	497.0	COG0322@1|root,COG0322@2|Bacteria,1MV38@1224|Proteobacteria,42MB1@68525|delta/epsilon subdivisions,2WJ76@28221|Deltaproteobacteria,2MIHC@213118|Desulfobacterales	28221|Deltaproteobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	GO:0005575,GO:0005622,GO:0005623,GO:0006950,GO:0006974,GO:0008150,GO:0009380,GO:0009987,GO:0032991,GO:0033554,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:1902494,GO:1905347,GO:1905348,GO:1990391	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N
HKD2_k127_8348190_7	1167006.UWK_02782	3.83e-17	85.0	COG2906@1|root,COG2906@2|Bacteria	2|Bacteria	P	2 iron, 2 sulfur cluster binding	MA20_04235	-	1.5.3.1	ko:K00303	ko00260,ko01100,map00260,map01100	-	R00610	RC00060,RC00557	ko00000,ko00001,ko01000	-	-	-	DAO,Fer2_BFD,Fer4,Pyr_redox_2
HKD2_k127_8348190_2	706587.Desti_1404	1.871e-111	388.0	COG0784@1|root,COG2202@1|root,COG4191@1|root,COG5000@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG4191@2|Bacteria,COG5000@2|Bacteria,1RCM9@1224|Proteobacteria,42M1R@68525|delta/epsilon subdivisions,2WK3J@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg,SBP_bac_3
HKD2_k127_8348190_1	1121403.AUCV01000033_gene3655	1.902e-123	406.0	COG0798@1|root,COG0798@2|Bacteria,1R33W@1224|Proteobacteria,42P1K@68525|delta/epsilon subdivisions,2WKET@28221|Deltaproteobacteria,2MIXR@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Sodium Bile acid symporter family	-	-	-	-	-	-	-	-	-	-	-	-	SBF,Usp
HKD2_k127_8348190_8	568076.XP_007824640.1	0.0002086	51.0	COG0666@1|root,KOG1477@1|root,KOG0504@2759|Eukaryota,KOG1477@2759|Eukaryota,KOG4177@2759|Eukaryota,38BVK@33154|Opisthokonta,3NXT8@4751|Fungi,3QTP3@4890|Ascomycota,2138J@147550|Sordariomycetes	4751|Fungi	M	ankyrin repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	Ank,Ank_2,Ank_4,Ank_5,F-box-like,SPRY
HKD2_k127_8348190_6	404380.Gbem_0378	7.098e-18	97.0	COG2199@1|root,COG3706@2|Bacteria,1QWNG@1224|Proteobacteria,42SDQ@68525|delta/epsilon subdivisions,2WP1N@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,Response_reg
HKD2_k127_8348190_3	357804.Ping_0484	3.044e-96	331.0	COG0642@1|root,COG0784@1|root,COG2198@1|root,COG2202@1|root,COG3614@1|root,COG0784@2|Bacteria,COG2198@2|Bacteria,COG2202@2|Bacteria,COG2205@2|Bacteria,COG3614@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria,2QIRM@267894|Psychromonadaceae	1236|Gammaproteobacteria	T	ATP-binding region, ATPase domain protein domain protein	rcsC	-	2.7.13.3	ko:K07677,ko:K20974	ko02020,ko02025,ko02026,map02020,map02025,map02026	M00474,M00820	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	CHASE,HATPase_c,HisKA,Hpt,MASE1,PAS,PAS_3,PAS_4,PAS_9,RcsC,Response_reg,SBP_bac_3
HKD2_k127_8420573_0	1121403.AUCV01000001_gene857	2.938e-252	785.0	COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,42MPZ@68525|delta/epsilon subdivisions,2WIR9@28221|Deltaproteobacteria,2MHQG@213118|Desulfobacterales	28221|Deltaproteobacteria	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
HKD2_k127_8420573_2	1121403.AUCV01000001_gene856	7.716e-159	509.0	COG0232@1|root,COG0232@2|Bacteria,1MVQ2@1224|Proteobacteria,42P1T@68525|delta/epsilon subdivisions,2WKZB@28221|Deltaproteobacteria,2MI0P@213118|Desulfobacterales	28221|Deltaproteobacteria	F	TIGRFAM deoxyguanosinetriphosphate triphosphohydrolase	-	-	3.1.5.1	ko:K01129	ko00230,map00230	-	R01856	RC00017	ko00000,ko00001,ko01000	-	-	-	HD,HD_assoc
HKD2_k127_8420573_3	589865.DaAHT2_0456	3.84e-78	278.0	COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,42MMF@68525|delta/epsilon subdivisions,2WJ1F@28221|Deltaproteobacteria,2MHQX@213118|Desulfobacterales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	-	-	-	ko:K11473	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	CCG,Fer4_8
HKD2_k127_8420573_1	1121403.AUCV01000001_gene855	4.046e-169	536.0	COG1186@1|root,COG1186@2|Bacteria,1MUAW@1224|Proteobacteria,42MKD@68525|delta/epsilon subdivisions,2WIZP@28221|Deltaproteobacteria,2MIG2@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA	prfB	-	-	ko:K02836	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
HKD2_k127_8420573_4	321332.CYB_2053	1.32e-07	62.0	2BZXA@1|root,33P5U@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_842409_7	572477.Alvin_1309	1.039e-67	238.0	2A5PE@1|root,30UE9@2|Bacteria,1PX3T@1224|Proteobacteria,1TA9Y@1236|Gammaproteobacteria,1WZSR@135613|Chromatiales	135613|Chromatiales	M	Protein of unknown function (DUF3313)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3313
HKD2_k127_842409_3	1403819.BATR01000067_gene2010	1.062e-140	450.0	COG2326@1|root,COG2326@2|Bacteria,46UWN@74201|Verrucomicrobia,2IVFJ@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Polyphosphate kinase 2 (PPK2)	-	-	-	-	-	-	-	-	-	-	-	-	PPK2
HKD2_k127_842409_1	768671.ThimaDRAFT_4559	4.344e-221	700.0	COG0659@1|root,COG0659@2|Bacteria,1MWDF@1224|Proteobacteria,1SYC8@1236|Gammaproteobacteria,1WXWA@135613|Chromatiales	135613|Chromatiales	U	sulphate transporter	-	-	-	-	-	-	-	-	-	-	-	-	STAS,Sulfate_transp
HKD2_k127_842409_5	335543.Sfum_1461	1.369e-98	334.0	COG4786@1|root,COG4786@2|Bacteria,1MZXB@1224|Proteobacteria,42MTK@68525|delta/epsilon subdivisions,2WM8U@28221|Deltaproteobacteria,2MQWV@213462|Syntrophobacterales	28221|Deltaproteobacteria	N	Protein of unknown function (DUF2950)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2950
HKD2_k127_842409_4	909663.KI867150_gene2890	1.786e-109	368.0	COG3064@1|root,COG3064@2|Bacteria,1MXPS@1224|Proteobacteria,42PA3@68525|delta/epsilon subdivisions,2WM6X@28221|Deltaproteobacteria,2MQSC@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	Protein of unknown function (DUF3300)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3300
HKD2_k127_842409_0	1304885.AUEY01000002_gene367	4.295e-294	924.0	COG5164@1|root,COG5164@2|Bacteria,1MX1Z@1224|Proteobacteria,42QIV@68525|delta/epsilon subdivisions,2WKX2@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	regulation of DNA-templated transcription, elongation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_842409_8	1396141.BATP01000001_gene5388	4.912e-37	149.0	COG1226@1|root,3171K@2|Bacteria,46WQS@74201|Verrucomicrobia	74201|Verrucomicrobia	P	Ion channel	-	-	-	-	-	-	-	-	-	-	-	-	Ion_trans_2
HKD2_k127_842409_6	1121403.AUCV01000067_gene2191	1.126e-73	259.0	2DS07@1|root,33DXS@2|Bacteria,1QWHF@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_842409_2	335543.Sfum_0673	6.591e-163	518.0	COG3408@1|root,COG3408@2|Bacteria,1QUN2@1224|Proteobacteria,42PYS@68525|delta/epsilon subdivisions,2WMEG@28221|Deltaproteobacteria,2MRGX@213462|Syntrophobacterales	28221|Deltaproteobacteria	G	Glycogen debranching enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_63
HKD2_k127_8432506_4	269799.Gmet_2437	1.089e-97	327.0	COG0745@1|root,COG0745@2|Bacteria,1MWZ5@1224|Proteobacteria,42QTM@68525|delta/epsilon subdivisions,2WN5R@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	Two component transcriptional regulator, winged helix family	kdpE	-	-	ko:K07667	ko02020,ko02024,map02020,map02024	M00454	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
HKD2_k127_8432506_0	243231.GSU2483	0.0	1219.0	COG0642@1|root,COG2205@2|Bacteria,1MUZQ@1224|Proteobacteria,42NZF@68525|delta/epsilon subdivisions,2WJNR@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Histidine kinase	kdpD	-	2.7.13.3	ko:K07646	ko02020,map02020	M00454	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	DUF4118,GAF_3,HATPase_c,HisKA,KdpD,Usp
HKD2_k127_8432506_5	243231.GSU2482	4.851e-73	250.0	COG2156@1|root,COG2156@2|Bacteria,1RABG@1224|Proteobacteria,42SC9@68525|delta/epsilon subdivisions,2WPDZ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex	kdpC	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0008556,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0015672,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044425,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132	3.6.3.12	ko:K01548	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	3.A.3.7	-	-	KdpC
HKD2_k127_8432506_1	269799.Gmet_2434	0.0	1085.0	COG2216@1|root,COG2216@2|Bacteria,1MU7D@1224|Proteobacteria,42NGX@68525|delta/epsilon subdivisions,2WJC0@28221|Deltaproteobacteria,43VZH@69541|Desulfuromonadales	28221|Deltaproteobacteria	P	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system	kdpB	-	3.6.3.12	ko:K01547	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	3.A.3.7	-	iAF987.Gmet_2434	E1-E2_ATPase,Hydrolase
HKD2_k127_8432506_2	269799.Gmet_2433	9.241e-289	897.0	COG2060@1|root,COG2060@2|Bacteria,1MV1K@1224|Proteobacteria,42NCD@68525|delta/epsilon subdivisions,2WJ03@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane	kdpA	GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0008556,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0015672,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0030955,GO:0031420,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043167,GO:0043169,GO:0043492,GO:0044464,GO:0046872,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0071944,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132	3.6.3.12	ko:K01546	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	3.A.3.7	-	-	KdpA
HKD2_k127_8432506_3	1220534.B655_0947	8.865e-101	365.0	arCOG02377@1|root,arCOG03931@1|root,arCOG07605@1|root,arCOG02377@2157|Archaea,arCOG03931@2157|Archaea,arCOG07605@2157|Archaea,2Y7PW@28890|Euryarchaeota	28890|Euryarchaeota	T	Histidine kinase-like ATPases	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_9
HKD2_k127_8432506_6	1167006.UWK_02548	1.273e-65	233.0	COG2930@1|root,COG2930@2|Bacteria,1RHV6@1224|Proteobacteria,42TN0@68525|delta/epsilon subdivisions,2WQ75@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Las17-binding protein actin regulator	-	-	-	-	-	-	-	-	-	-	-	-	Ysc84
HKD2_k127_8432506_7	1121403.AUCV01000010_gene1391	2.964e-25	105.0	COG1773@1|root,COG1773@2|Bacteria,1N99T@1224|Proteobacteria,42V8B@68525|delta/epsilon subdivisions,2WRUJ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM Rubredoxin-type Fe(Cys)4 protein	-	-	-	-	-	-	-	-	-	-	-	-	Rubredoxin
HKD2_k127_8456207_1	1121403.AUCV01000012_gene4113	8.126e-65	227.0	COG0623@1|root,COG0623@2|Bacteria,1R090@1224|Proteobacteria,43CRU@68525|delta/epsilon subdivisions,2X7ZF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HKD2_k127_8456207_0	1121403.AUCV01000012_gene4112	1.504e-79	274.0	COG2006@1|root,COG2006@2|Bacteria,1RABP@1224|Proteobacteria,42QQA@68525|delta/epsilon subdivisions,2WMRX@28221|Deltaproteobacteria,2MK55@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF362,Fer4
HKD2_k127_8462181_0	1121403.AUCV01000004_gene2019	2.787e-242	769.0	COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,42NID@68525|delta/epsilon subdivisions,2WJ4P@28221|Deltaproteobacteria,2MJ6G@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Belongs to the peptidase S41A family	prc	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	DUF3340,PDZ,Peptidase_S41
HKD2_k127_8462181_2	1121403.AUCV01000004_gene2020	6.454e-59	209.0	2CDHP@1|root,32RXU@2|Bacteria,1N1BP@1224|Proteobacteria,42TPT@68525|delta/epsilon subdivisions,2WQE6@28221|Deltaproteobacteria,2MJZK@213118|Desulfobacterales	28221|Deltaproteobacteria	S	RsbT co-antagonist protein rsbRD N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	RsbRD_N
HKD2_k127_8462181_1	1121403.AUCV01000004_gene2021	5.894e-139	446.0	COG2181@1|root,COG2181@2|Bacteria,1R48S@1224|Proteobacteria,42MZU@68525|delta/epsilon subdivisions,2WKKU@28221|Deltaproteobacteria,2MI6J@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM Nitrate reductase gamma subunit	dsrM	-	1.7.5.1	ko:K00374	ko00910,ko01120,ko02020,map00910,map01120,map02020	M00529,M00530	R00798,R01106,R09497	RC02812	ko00000,ko00001,ko00002,ko01000	5.A.3.1	-	-	Nitrate_red_gam
HKD2_k127_8471291_0	118173.KB235914_gene1738	6.752e-139	449.0	COG1899@1|root,COG1899@2|Bacteria,1G448@1117|Cyanobacteria,1H6YM@1150|Oscillatoriales	1117|Cyanobacteria	O	Belongs to the deoxyhypusine synthase family	-	-	2.5.1.46	ko:K00809	-	-	-	-	ko00000,ko01000	-	-	-	DS
HKD2_k127_8471291_1	1517681.HW45_28780	1.155e-28	123.0	2ESJC@1|root,33K41@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8471291_3	243090.RB12768	0.0001562	54.0	COG2804@1|root,COG2804@2|Bacteria,2IXSA@203682|Planctomycetes	203682|Planctomycetes	NU	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB	-	-	-	ko:K02652	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE,T2SSE_N
HKD2_k127_8471291_2	1460634.JCM19037_2771	2.824e-05	58.0	COG2373@1|root,COG4932@1|root,COG2373@2|Bacteria,COG4932@2|Bacteria	2|Bacteria	M	domain protein	-	-	-	ko:K06894	-	-	-	-	ko00000	-	-	-	A2M_N,CarboxypepD_reg
HKD2_k127_8475807_7	1267535.KB906767_gene5104	2.711e-15	80.0	COG1502@1|root,COG3266@1|root,COG1502@2|Bacteria,COG3266@2|Bacteria,3Y6X8@57723|Acidobacteria,2JKY1@204432|Acidobacteriia	204432|Acidobacteriia	I	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8475807_0	1337936.IJ00_19125	1.328e-100	357.0	COG0635@1|root,COG0635@2|Bacteria,1G0BZ@1117|Cyanobacteria,1HKQT@1161|Nostocales	1117|Cyanobacteria	H	Belongs to the anaerobic coproporphyrinogen-III oxidase family	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
HKD2_k127_8475807_2	1337936.IJ00_19120	5.933e-54	215.0	COG0697@1|root,COG0697@2|Bacteria,1G0QG@1117|Cyanobacteria,1HKH8@1161|Nostocales	1117|Cyanobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HKD2_k127_8475807_5	1123376.AUIU01000014_gene538	6.548e-20	103.0	COG0778@1|root,COG0778@2|Bacteria	2|Bacteria	C	coenzyme F420-1:gamma-L-glutamate ligase activity	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
HKD2_k127_8475807_8	317619.ANKN01000066_gene2803	1.422e-12	80.0	COG0498@1|root,COG0498@2|Bacteria,1G31E@1117|Cyanobacteria,1MKIG@1212|Prochloraceae	2|Bacteria	E	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine	thrC	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP,Response_reg
HKD2_k127_8475807_3	1538295.JY96_18505	2.787e-43	170.0	COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,2VIRD@28216|Betaproteobacteria,1KJ3D@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Belongs to the alpha-IPM synthase homocitrate synthase family	nifV	-	2.3.3.14	ko:K02594	ko00620,map00620	-	R00271	RC00004,RC00067,RC02754	ko00000,ko00001,ko01000	-	-	-	HMGL-like
HKD2_k127_8475807_4	768671.ThimaDRAFT_3623	4.58e-29	126.0	COG0500@1|root,COG2226@2|Bacteria,1PVPS@1224|Proteobacteria,1T2X1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	methyltransferase type	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25,Methyltransf_31
HKD2_k127_8475807_1	335543.Sfum_2535	1.665e-68	248.0	COG1361@1|root,COG4733@1|root,COG1361@2|Bacteria,COG4733@2|Bacteria,1R5HW@1224|Proteobacteria,42R1Y@68525|delta/epsilon subdivisions,2WMXD@28221|Deltaproteobacteria,2MS7R@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	Protein of unknown function (DUF1566)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1566
HKD2_k127_8475807_6	398767.Glov_2339	3.495e-18	89.0	COG1361@1|root,COG3055@1|root,COG4409@1|root,COG4932@1|root,COG1361@2|Bacteria,COG3055@2|Bacteria,COG4409@2|Bacteria,COG4932@2|Bacteria,1R5HW@1224|Proteobacteria,42R1Y@68525|delta/epsilon subdivisions,2WMXD@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Protein of unknown function (DUF1566)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1566
HKD2_k127_8478642_1	765420.OSCT_1950	2.225e-38	162.0	COG0457@1|root,COG0457@2|Bacteria,2G71Q@200795|Chloroflexi,376GZ@32061|Chloroflexia	32061|Chloroflexia	NU	SMART Tetratricopeptide domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CHAT,NB-ARC,TPR_10,TPR_12,TPR_16,TPR_7
HKD2_k127_8478642_0	880072.Desac_2171	7.346e-124	424.0	COG0417@1|root,COG0417@2|Bacteria	2|Bacteria	L	DNA replication proofreading	polB	-	2.7.7.7	ko:K02336,ko:K06877	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	CarbopepD_reg_2,DNA_pol_B,DNA_pol_B_exo1,RNase_H_2
HKD2_k127_8478642_2	880072.Desac_2172	1.467e-09	65.0	arCOG07300@1|root,2ZTGG@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8583639_2	1121403.AUCV01000027_gene2521	1.644e-74	262.0	COG0266@1|root,COG0266@2|Bacteria,1MVM5@1224|Proteobacteria,42R8W@68525|delta/epsilon subdivisions,2WMZU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates	fpg	-	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
HKD2_k127_8583639_3	247490.KSU1_B0518	5.282e-63	231.0	COG4275@1|root,COG4275@2|Bacteria	2|Bacteria	S	Chromate resistance exported protein	chrB	-	-	-	-	-	-	-	-	-	-	-	Chrome_Resist
HKD2_k127_8583639_0	1396141.BATP01000004_gene5882	2.62e-139	456.0	COG2059@1|root,COG2059@2|Bacteria,46V8S@74201|Verrucomicrobia,2IUYF@203494|Verrucomicrobiae	203494|Verrucomicrobiae	P	Chromate transporter	-	-	-	-	-	-	-	-	-	-	-	-	Chromate_transp
HKD2_k127_8583639_4	589865.DaAHT2_1950	1.703e-12	69.0	COG1418@1|root,COG1418@2|Bacteria,1RJ5Y@1224|Proteobacteria,42SYN@68525|delta/epsilon subdivisions,2WP8J@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	SMART metal-dependent phosphohydrolase, HD region	-	-	-	ko:K06950	-	-	-	-	ko00000	-	-	-	HD
HKD2_k127_8583639_1	589865.DaAHT2_1951	7.85e-90	308.0	COG0477@1|root,COG2814@2|Bacteria,1MVSH@1224|Proteobacteria,42NA4@68525|delta/epsilon subdivisions,2WIJM@28221|Deltaproteobacteria	28221|Deltaproteobacteria	EGP	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD2_k127_8654233_6	1167006.UWK_02742	8.248e-15	75.0	COG0563@1|root,COG0563@2|Bacteria,1MXCZ@1224|Proteobacteria,42M8E@68525|delta/epsilon subdivisions,2WJH0@28221|Deltaproteobacteria,2MNE9@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism	adk	GO:0003674,GO:0003824,GO:0004017,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901576	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ADK,ADK_lid
HKD2_k127_8654233_4	1121403.AUCV01000010_gene1340	3.762e-49	180.0	COG0071@1|root,COG0071@2|Bacteria,1N7C7@1224|Proteobacteria,42U0T@68525|delta/epsilon subdivisions,2WRBN@28221|Deltaproteobacteria,2MM12@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Hsp20/alpha crystallin family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
HKD2_k127_8654233_5	589865.DaAHT2_0432	7.351e-41	154.0	COG0071@1|root,COG0071@2|Bacteria,1NA27@1224|Proteobacteria,42VE3@68525|delta/epsilon subdivisions,2WR9Q@28221|Deltaproteobacteria,2MMAN@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
HKD2_k127_8654233_3	1121403.AUCV01000010_gene1338	6.265e-66	235.0	COG3170@1|root,COG3170@2|Bacteria,1REZ7@1224|Proteobacteria,42RFW@68525|delta/epsilon subdivisions,2WS8K@28221|Deltaproteobacteria	28221|Deltaproteobacteria	NU	Protein of unknown function (DUF3108)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3108
HKD2_k127_8654233_0	1121403.AUCV01000010_gene1337	2.382e-127	412.0	COG0382@1|root,COG0382@2|Bacteria,1MV4Q@1224|Proteobacteria,42MXH@68525|delta/epsilon subdivisions,2WK8E@28221|Deltaproteobacteria,2MITG@213118|Desulfobacterales	28221|Deltaproteobacteria	H	4-hydroxybenzoate polyprenyltransferase	ubiA	-	2.5.1.39	ko:K03179	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R05000,R05615	RC00209,RC02895	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
HKD2_k127_8654233_2	1167006.UWK_02240	1.862e-85	291.0	COG1355@1|root,COG1355@2|Bacteria,1MXK5@1224|Proteobacteria,42R55@68525|delta/epsilon subdivisions,2WN4E@28221|Deltaproteobacteria,2MPVZ@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Belongs to the MEMO1 family	-	-	-	ko:K06990	-	-	-	-	ko00000,ko04812	-	-	-	Memo
HKD2_k127_8654233_1	177439.DP2928	2.474e-98	327.0	COG0215@1|root,COG0215@2|Bacteria,1MV8H@1224|Proteobacteria,42M04@68525|delta/epsilon subdivisions,2WJJD@28221|Deltaproteobacteria,2MIN7@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e,tRNA-synt_1g
HKD2_k127_8688000_0	1121403.AUCV01000008_gene1503	5.731e-156	514.0	COG0769@1|root,COG0770@1|root,COG0769@2|Bacteria,COG0770@2|Bacteria,1QTSF@1224|Proteobacteria,43BV1@68525|delta/epsilon subdivisions,2X760@28221|Deltaproteobacteria,2MPKR@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan	murE	-	6.3.2.10,6.3.2.13	ko:K15792	ko00300,ko00550,map00300,map00550	-	R02788,R04617	RC00064,RC00090,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
HKD2_k127_8688000_2	1121403.AUCV01000008_gene1502	6.291e-87	311.0	COG0768@1|root,COG0768@2|Bacteria	2|Bacteria	M	penicillin binding	pbp2	-	3.4.16.4	ko:K03587	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011,ko03036	-	-	-	IAT_beta,PASTA,PBP_dimer,Transpeptidase
HKD2_k127_8688000_1	589865.DaAHT2_1488	2.096e-97	326.0	COG0275@1|root,COG0275@2|Bacteria,1MUT4@1224|Proteobacteria,42N5Q@68525|delta/epsilon subdivisions,2WJ8J@28221|Deltaproteobacteria,2MJ20@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA	rsmH	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.199	ko:K03438	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltransf_5
HKD2_k127_8688000_3	1121403.AUCV01000008_gene1499	9.789e-43	161.0	COG2001@1|root,COG2001@2|Bacteria,1RHCG@1224|Proteobacteria,42TRZ@68525|delta/epsilon subdivisions,2WQRI@28221|Deltaproteobacteria,2MKIW@213118|Desulfobacterales	28221|Deltaproteobacteria	K	Belongs to the MraZ family	mraZ	GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031333,GO:0043254,GO:0043565,GO:0044087,GO:0044212,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2000142,GO:2000143,GO:2001141	-	ko:K03925	-	-	-	-	ko00000	-	-	-	MraZ
HKD2_k127_875163_2	1167006.UWK_01018	4.802e-147	481.0	COG0348@1|root,COG1143@1|root,COG1245@1|root,COG0348@2|Bacteria,COG1143@2|Bacteria,COG1245@2|Bacteria,1MY5M@1224|Proteobacteria,43BPV@68525|delta/epsilon subdivisions,2WJVS@28221|Deltaproteobacteria,2MPI2@213118|Desulfobacterales	28221|Deltaproteobacteria	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_5,Fer4_7
HKD2_k127_875163_6	1121403.AUCV01000013_gene3972	1.134e-93	312.0	COG1251@1|root,COG1251@2|Bacteria,1MW58@1224|Proteobacteria,42R33@68525|delta/epsilon subdivisions,2WMY1@28221|Deltaproteobacteria,2MMXB@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Nitrite/Sulfite reductase ferredoxin-like half domain	-	-	-	-	-	-	-	-	-	-	-	-	NIR_SIR,NIR_SIR_ferr
HKD2_k127_875163_7	290512.Paes_0794	5.793e-51	189.0	COG1309@1|root,COG1309@2|Bacteria	2|Bacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	DUF1956,TetR_N
HKD2_k127_875163_1	644282.Deba_0020	1.43e-150	490.0	COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,42MRU@68525|delta/epsilon subdivisions,2WIQX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	MU	TIGRFAM RND efflux system, outer membrane lipoprotein, NodT	-	-	-	-	-	-	-	-	-	-	-	-	OEP
HKD2_k127_875163_4	56780.SYN_00852	6.327e-118	394.0	COG0845@1|root,COG0845@2|Bacteria,1MU8D@1224|Proteobacteria,42NVA@68525|delta/epsilon subdivisions,2WMQK@28221|Deltaproteobacteria,2MQ4F@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	HlyD family secretion protein	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	HlyD_D23
HKD2_k127_875163_5	56780.SYN_00853	6.218e-111	362.0	COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,42P96@68525|delta/epsilon subdivisions,2WJE9@28221|Deltaproteobacteria,2MQA4@213462|Syntrophobacterales	28221|Deltaproteobacteria	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD2_k127_875163_0	555778.Hneap_0780	5.803e-168	548.0	COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,1T1FT@1236|Gammaproteobacteria,1WXYB@135613|Chromatiales	135613|Chromatiales	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HKD2_k127_875163_3	1167006.UWK_00694	7.521e-126	436.0	COG2204@1|root,COG5000@1|root,COG2204@2|Bacteria,COG5000@2|Bacteria,1NU7E@1224|Proteobacteria	1224|Proteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_7,PAS_8,PAS_9,Response_reg,dCache_2
HKD2_k127_875163_8	768670.Calni_0197	1.991e-37	155.0	COG3221@1|root,COG3221@2|Bacteria,2GGP8@200930|Deferribacteres	200930|Deferribacteres	P	ABC transporter, phosphonate, periplasmic substrate-binding protein	-	-	-	ko:K02044	ko02010,map02010	M00223	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.9	-	-	Phosphonate-bd
HKD2_k127_875163_9	439235.Dalk_4014	3.945e-34	137.0	COG2259@1|root,COG2259@2|Bacteria,1N0SR@1224|Proteobacteria,42TTN@68525|delta/epsilon subdivisions,2WQQP@28221|Deltaproteobacteria,2MM0G@213118|Desulfobacterales	28221|Deltaproteobacteria	S	DoxX	-	-	-	-	-	-	-	-	-	-	-	-	MauE
HKD2_k127_875163_10	748247.AZKH_0625	2.862e-31	128.0	2CNK3@1|root,32SH9@2|Bacteria,1N02U@1224|Proteobacteria,2VUNW@28216|Betaproteobacteria,2KX0T@206389|Rhodocyclales	206389|Rhodocyclales	S	Protein of Unknown function (DUF2784)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2784
HKD2_k127_875163_11	211165.AJLN01000063_gene3762	1.092e-15	81.0	COG0737@1|root,COG0737@2|Bacteria,1GBZ0@1117|Cyanobacteria,1JMFB@1189|Stigonemataceae	1117|Cyanobacteria	F	5'-nucleotidase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	5_nucleotid_C,Metallophos
HKD2_k127_8753425_6	1121403.AUCV01000024_gene3434	5.317e-13	70.0	COG0484@1|root,COG0484@2|Bacteria,1MVMS@1224|Proteobacteria,42KZM@68525|delta/epsilon subdivisions,2WJGP@28221|Deltaproteobacteria,2MIAD@213118|Desulfobacterales	28221|Deltaproteobacteria	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
HKD2_k127_8753425_3	1121403.AUCV01000024_gene3433	5.117e-53	192.0	COG0315@1|root,COG0315@2|Bacteria,1RCYZ@1224|Proteobacteria,42SNY@68525|delta/epsilon subdivisions,2WP2P@28221|Deltaproteobacteria,2MJU1@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)	moaC	-	4.6.1.17	ko:K03637	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R11372	RC03425	ko00000,ko00001,ko01000	-	-	-	MoaC
HKD2_k127_8753425_4	1121403.AUCV01000024_gene3432	1.683e-49	179.0	COG1734@1|root,COG1734@2|Bacteria,1RD08@1224|Proteobacteria,42RVK@68525|delta/epsilon subdivisions,2WNNA@28221|Deltaproteobacteria,2MJSM@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters	dksA	-	-	ko:K06204	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000,ko03009,ko03021	-	-	-	zf-dskA_traR
HKD2_k127_8753425_1	1121403.AUCV01000024_gene3431	4.422e-181	570.0	COG1085@1|root,COG1085@2|Bacteria,1MU3E@1224|Proteobacteria,42MP4@68525|delta/epsilon subdivisions,2WKT8@28221|Deltaproteobacteria,2MKY0@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Galactose-1-phosphate uridyl transferase, N-terminal domain	galT	-	2.7.7.12	ko:K00965	ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917	M00362,M00554,M00632	R00955	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF4921,GalP_UDP_tr_C,GalP_UDP_transf
HKD2_k127_8753425_5	1167006.UWK_02315	5.576e-49	177.0	COG0745@1|root,COG0745@2|Bacteria,1N3R6@1224|Proteobacteria,42TU3@68525|delta/epsilon subdivisions,2WQ9W@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	PFAM response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
HKD2_k127_8753425_2	589865.DaAHT2_1707	8.975e-84	285.0	COG1469@1|root,COG1469@2|Bacteria,1MV1B@1224|Proteobacteria,42N4U@68525|delta/epsilon subdivisions,2WJR7@28221|Deltaproteobacteria,2MHSN@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Converts GTP to 7,8-dihydroneopterin triphosphate	folE2	-	3.5.4.16	ko:K09007	ko00790,ko01100,map00790,map01100	M00126	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	-	GCHY-1
HKD2_k127_8753425_0	1121403.AUCV01000024_gene3428	2.269e-250	790.0	COG0751@1|root,COG0751@2|Bacteria,1MV2F@1224|Proteobacteria,42M6A@68525|delta/epsilon subdivisions,2WJIT@28221|Deltaproteobacteria,2MHVB@213118|Desulfobacterales	28221|Deltaproteobacteria	J	glycyl-tRNA synthetase, beta	glyS	-	6.1.1.14	ko:K01879	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_1,tRNA_synt_2f
HKD2_k127_8771804_0	1232410.KI421426_gene1511	2.218e-73	255.0	COG1136@1|root,COG1136@2|Bacteria,1RE7J@1224|Proteobacteria,43AW8@68525|delta/epsilon subdivisions,2X6AH@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD2_k127_8771804_1	1232410.KI421426_gene1512	3.337e-56	202.0	COG4591@1|root,COG4591@2|Bacteria,1R4Q2@1224|Proteobacteria,42N3Y@68525|delta/epsilon subdivisions,2WJFS@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HKD2_k127_8787646_12	1121403.AUCV01000024_gene3425	1.374e-37	145.0	COG1333@1|root,COG1333@2|Bacteria,1N6XE@1224|Proteobacteria,42NBB@68525|delta/epsilon subdivisions,2WIMD@28221|Deltaproteobacteria,2MIEB@213118|Desulfobacterales	28221|Deltaproteobacteria	O	PFAM ResB family protein	-	-	-	ko:K07399	-	-	-	-	ko00000	-	-	-	ResB
HKD2_k127_8787646_13	1121403.AUCV01000008_gene1556	9.808e-29	116.0	COG0227@1|root,COG0227@2|Bacteria,1PTFN@1224|Proteobacteria,42V1S@68525|delta/epsilon subdivisions,2WR85@28221|Deltaproteobacteria,2MKZY@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Belongs to the bacterial ribosomal protein bL28 family	rpmB	GO:0003674,GO:0003735,GO:0005198	-	ko:K02902	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L28
HKD2_k127_8787646_7	1265505.ATUG01000001_gene4280	1.274e-87	300.0	COG1028@1|root,COG1028@2|Bacteria,1R7KW@1224|Proteobacteria,42NF5@68525|delta/epsilon subdivisions,2WM4D@28221|Deltaproteobacteria,2MIF5@213118|Desulfobacterales	28221|Deltaproteobacteria	IQ	PFAM short-chain dehydrogenase reductase SDR	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HKD2_k127_8787646_1	1121403.AUCV01000008_gene1566	4.465e-280	890.0	COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,42NYP@68525|delta/epsilon subdivisions,2WIPJ@28221|Deltaproteobacteria,2MIG6@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Belongs to the peptidase M16 family	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
HKD2_k127_8787646_6	1121403.AUCV01000008_gene1567	5.453e-108	357.0	COG0589@1|root,COG0589@2|Bacteria,1RF1N@1224|Proteobacteria,42S7A@68525|delta/epsilon subdivisions,2WNZK@28221|Deltaproteobacteria,2MKM5@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD2_k127_8787646_0	1123368.AUIS01000009_gene2455	0.0	1069.0	COG0308@1|root,COG0308@2|Bacteria,1MUCI@1224|Proteobacteria,1RMA7@1236|Gammaproteobacteria,2NC0P@225057|Acidithiobacillales	225057|Acidithiobacillales	E	Domain of unknown function (DUF3458_C) ARM repeats	pepN	-	3.4.11.2	ko:K01256	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	DUF3458,DUF3458_C,Peptidase_M1
HKD2_k127_8787646_15	279714.FuraDRAFT_3812	7.746e-23	100.0	2EGD6@1|root,33A4Z@2|Bacteria,1N733@1224|Proteobacteria,2VVS2@28216|Betaproteobacteria,2KS1I@206351|Neisseriales	206351|Neisseriales	S	Protein of unknown function (DUF2892)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2892
HKD2_k127_8787646_9	1121403.AUCV01000014_gene4617	1.444e-58	211.0	COG0155@1|root,COG0155@2|Bacteria	2|Bacteria	C	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family	cbiH	-	1.7.7.1,2.1.1.131,2.1.1.272	ko:K00366,ko:K05934,ko:K21479	ko00860,ko00910,ko01100,ko01120,map00860,map00910,map01100,map01120	M00531	R00790,R05180,R05809,R11580	RC00003,RC00176,RC01293,RC03471,RC03479	ko00000,ko00001,ko00002,ko01000	-	-	-	NIR_SIR,NIR_SIR_ferr,TP_methylase
HKD2_k127_8787646_17	1395571.TMS3_0121515	1.47e-21	98.0	2DNYP@1|root,32ZTI@2|Bacteria,1N747@1224|Proteobacteria,1SCCQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function (DUF2905)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2905
HKD2_k127_8787646_14	153948.NAL212_2068	2.495e-24	105.0	2CEDU@1|root,333S9@2|Bacteria,1NCM4@1224|Proteobacteria,2WE3J@28216|Betaproteobacteria,374B8@32003|Nitrosomonadales	28216|Betaproteobacteria	M	Domain of unknown function (DUF4156)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4156
HKD2_k127_8787646_5	439235.Dalk_2902	3.151e-112	375.0	COG0389@1|root,COG0389@2|Bacteria,1MUUH@1224|Proteobacteria,42NGG@68525|delta/epsilon subdivisions,2WIVT@28221|Deltaproteobacteria,2MHKT@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	dinB	-	2.7.7.7	ko:K02346	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C,IMS_HHH
HKD2_k127_8787646_8	1232437.KL662064_gene4057	9.745e-71	246.0	COG0491@1|root,COG0491@2|Bacteria,1MUDN@1224|Proteobacteria,42QWD@68525|delta/epsilon subdivisions,2WNNG@28221|Deltaproteobacteria,2MNHD@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HKD2_k127_8787646_10	1167006.UWK_01272	7.628e-55	202.0	COG0226@1|root,COG0226@2|Bacteria	2|Bacteria	P	phosphate ion binding	sphX	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
HKD2_k127_8787646_18	1047013.AQSP01000090_gene661	2.322e-06	53.0	COG1396@1|root,COG1396@2|Bacteria	2|Bacteria	K	sequence-specific DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3,HTH_31
HKD2_k127_8787646_4	1121403.AUCV01000018_gene3185	2.909e-144	482.0	COG2202@1|root,COG4191@1|root,COG2202@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MFW@68525|delta/epsilon subdivisions,2WKMP@28221|Deltaproteobacteria,2MI6S@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_9,Response_reg,dCache_1
HKD2_k127_8787646_2	1121403.AUCV01000007_gene1233	1.505e-222	701.0	COG1282@1|root,COG1282@2|Bacteria,1MUP4@1224|Proteobacteria,42NHS@68525|delta/epsilon subdivisions,2WJHI@28221|Deltaproteobacteria,2MIF6@213118|Desulfobacterales	28221|Deltaproteobacteria	C	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane	-	-	1.6.1.2	ko:K00325	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	PNTB
HKD2_k127_8787646_11	1121403.AUCV01000007_gene1232	3.421e-40	150.0	COG3288@1|root,COG3288@2|Bacteria,1MZ3E@1224|Proteobacteria,42WKN@68525|delta/epsilon subdivisions,2WRXH@28221|Deltaproteobacteria,2MPR6@213118|Desulfobacterales	28221|Deltaproteobacteria	C	4TM region of pyridine nucleotide transhydrogenase, mitoch	-	-	1.6.1.2	ko:K00324	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	PNTB_4TM
HKD2_k127_8787646_3	1121403.AUCV01000007_gene1231	8.662e-184	580.0	COG3288@1|root,COG3288@2|Bacteria,1MVXU@1224|Proteobacteria,42NHC@68525|delta/epsilon subdivisions,2WJQJ@28221|Deltaproteobacteria,2MJKV@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Alanine dehydrogenase/PNT, C-terminal domain	pntA	-	1.6.1.2	ko:K00324	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N,PNTB_4TM
HKD2_k127_8787646_19	264732.Moth_0147	3.002e-05	48.0	COG0042@1|root,COG0042@2|Bacteria,1TQ2R@1239|Firmicutes,248HD@186801|Clostridia,42EUC@68295|Thermoanaerobacterales	186801|Clostridia	H	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines	dus	-	-	ko:K05540	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Dus
HKD2_k127_8807540_1	1121403.AUCV01000008_gene1534	4.696e-131	425.0	COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,42N87@68525|delta/epsilon subdivisions,2WK1B@28221|Deltaproteobacteria,2MHU5@213118|Desulfobacterales	28221|Deltaproteobacteria	S	pfam abc-1	-	-	-	ko:K03688	-	-	-	-	ko00000	-	-	-	ABC1,APH
HKD2_k127_8807540_0	1121403.AUCV01000035_gene3804	7.466e-157	510.0	COG0575@1|root,COG1408@1|root,COG0575@2|Bacteria,COG1408@2|Bacteria,1MUH5@1224|Proteobacteria,42Q51@68525|delta/epsilon subdivisions,2WIMQ@28221|Deltaproteobacteria,2MHZJ@213118|Desulfobacterales	28221|Deltaproteobacteria	I	CDP-archaeol synthase	-	-	-	ko:K07098	-	-	-	-	ko00000	-	-	-	CarS-like,Metallophos
HKD2_k127_8817345_10	1122197.ATWI01000013_gene2281	3.727e-21	102.0	COG1520@1|root,COG1520@2|Bacteria,1QV8R@1224|Proteobacteria,1SAWZ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8817345_9	316067.Geob_3270	1.528e-45	170.0	COG1487@1|root,COG1487@2|Bacteria,1MZZ9@1224|Proteobacteria,42UZN@68525|delta/epsilon subdivisions,2WQ62@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	-	-	-	-	-	-	-	-	-	PIN
HKD2_k127_8817345_11	706587.Desti_0629	1.477e-20	92.0	COG5450@1|root,COG5450@2|Bacteria,1Q2TR@1224|Proteobacteria,42W8I@68525|delta/epsilon subdivisions,2WRTI@28221|Deltaproteobacteria,2MS5V@213462|Syntrophobacterales	28221|Deltaproteobacteria	K	Bacterial antitoxin of type II TA system, VapB	-	-	-	-	-	-	-	-	-	-	-	-	VapB_antitoxin
HKD2_k127_8817345_7	1121403.AUCV01000012_gene4090	1.046e-83	283.0	COG1136@1|root,COG1136@2|Bacteria,1MVSQ@1224|Proteobacteria,42QNS@68525|delta/epsilon subdivisions,2WMSN@28221|Deltaproteobacteria,2MNIE@213118|Desulfobacterales	28221|Deltaproteobacteria	V	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner	lolD	-	-	ko:K09810	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.125	-	-	ABC_tran
HKD2_k127_8817345_3	1121403.AUCV01000012_gene4091	1.499e-182	579.0	COG4591@1|root,COG4591@2|Bacteria,1MVV7@1224|Proteobacteria,42MV0@68525|delta/epsilon subdivisions,2WITK@28221|Deltaproteobacteria,2MHM1@213118|Desulfobacterales	28221|Deltaproteobacteria	M	TIGRFAM lipoprotein releasing system, transmembrane protein, LolC E family	lolC	-	-	ko:K09808	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.125	-	-	FtsX,MacB_PCD
HKD2_k127_8817345_1	1121403.AUCV01000012_gene4092	1.471e-259	812.0	COG1190@1|root,COG1190@2|Bacteria,1MX1V@1224|Proteobacteria,42M90@68525|delta/epsilon subdivisions,2WJ9G@28221|Deltaproteobacteria,2MHV2@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Belongs to the class-II aminoacyl-tRNA synthetase family	lysS	-	6.1.1.6	ko:K04567	ko00970,map00970	M00359,M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
HKD2_k127_8817345_5	589865.DaAHT2_1305	3.055e-112	374.0	COG0620@1|root,COG0620@2|Bacteria,1R6KI@1224|Proteobacteria,42PCN@68525|delta/epsilon subdivisions,2WKT3@28221|Deltaproteobacteria,2MID3@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8817345_6	1121403.AUCV01000012_gene4093	3.31e-96	331.0	COG2265@1|root,COG2265@2|Bacteria,1MV3A@1224|Proteobacteria,42ME9@68525|delta/epsilon subdivisions,2WKF0@28221|Deltaproteobacteria,2MHW2@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family	rumA	-	2.1.1.190	ko:K03215	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TRAM,tRNA_U5-meth_tr
HKD2_k127_8817345_4	1125863.JAFN01000001_gene2253	1.416e-155	505.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	ko:K02481,ko:K07713	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD2_k127_8817345_2	1121403.AUCV01000012_gene4096	2.808e-233	727.0	COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,42MQI@68525|delta/epsilon subdivisions,2WN1S@28221|Deltaproteobacteria,2MJMW@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Aminotransferase class I and II	-	-	2.6.1.2	ko:K00814	ko00220,ko00250,ko00710,ko01100,ko01120,ko01200,ko01210,ko01230,map00220,map00250,map00710,map01100,map01120,map01200,map01210,map01230	M00171	R00258	RC00006,RC00008	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
HKD2_k127_8817345_8	1121403.AUCV01000012_gene4097	3.99e-59	213.0	COG0576@1|root,COG0576@2|Bacteria,1RH8T@1224|Proteobacteria,42TM2@68525|delta/epsilon subdivisions,2WQ0U@28221|Deltaproteobacteria,2MJZ6@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	grpE	GO:0000166,GO:0000774,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0017076,GO:0030234,GO:0030554,GO:0036094,GO:0044424,GO:0044444,GO:0044464,GO:0050790,GO:0051082,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0097159,GO:0098772,GO:1901265,GO:1901363	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
HKD2_k127_8817345_0	1121403.AUCV01000012_gene4098	2.5e-323	994.0	COG0443@1|root,COG0443@2|Bacteria,1MVEN@1224|Proteobacteria,42M64@68525|delta/epsilon subdivisions,2WIWS@28221|Deltaproteobacteria,2MJ2X@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
HKD2_k127_8842153_0	323261.Noc_1387	2.104e-293	912.0	COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,1S0BH@1236|Gammaproteobacteria,1X076@135613|Chromatiales	135613|Chromatiales	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	-	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
HKD2_k127_8856326_2	177439.DP2100	7.554e-135	443.0	COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,42MKS@68525|delta/epsilon subdivisions,2WKIH@28221|Deltaproteobacteria,2MI42@213118|Desulfobacterales	28221|Deltaproteobacteria	Q	PFAM amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
HKD2_k127_8856326_21	633131.TR2A62_1584	8.491e-17	85.0	COG0790@1|root,COG0790@2|Bacteria,1MWPA@1224|Proteobacteria,2TR2B@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Sel1 domain protein repeat-containing protein	-	-	-	ko:K07126	-	-	-	-	ko00000	-	-	-	Sel1
HKD2_k127_8856326_13	349124.Hhal_0141	7.243e-48	182.0	COG4244@1|root,COG4244@2|Bacteria	2|Bacteria	E	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF2231,Fn3_assoc,PSCyt1,PSCyt2,PSD1
HKD2_k127_8856326_5	123214.PERMA_0022	3.113e-128	427.0	COG0469@1|root,COG0469@2|Bacteria,2G3TG@200783|Aquificae	200783|Aquificae	G	Belongs to the pyruvate kinase family	-	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PK,PK_C
HKD2_k127_8856326_8	314345.SPV1_12235	9.553e-89	297.0	COG2095@1|root,COG2095@2|Bacteria,1MX5T@1224|Proteobacteria	1224|Proteobacteria	U	UPF0056 membrane protein	ychE	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K05595	-	-	-	-	ko00000,ko02000	2.A.95.1	-	-	MarC
HKD2_k127_8856326_14	997829.HMPREF1121_00080	1.022e-47	183.0	COG1192@1|root,COG1192@2|Bacteria,4NFEX@976|Bacteroidetes,2FMX2@200643|Bacteroidia,22W77@171551|Porphyromonadaceae	976|Bacteroidetes	D	Chromosome partitioning protein ParA	soj	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
HKD2_k127_8856326_9	944481.JAFP01000001_gene480	3.939e-70	272.0	COG0643@1|root,COG0784@1|root,COG0643@2|Bacteria,COG0784@2|Bacteria,1MUAG@1224|Proteobacteria,42M6Q@68525|delta/epsilon subdivisions,2WJ5U@28221|Deltaproteobacteria,2M6JZ@213113|Desulfurellales	28221|Deltaproteobacteria	T	Histidine Phosphotransfer domain	cheA64H	-	2.7.13.3	ko:K03407	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg
HKD2_k127_8856326_22	526222.Desal_0213	1.702e-16	94.0	COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,42N03@68525|delta/epsilon subdivisions,2WIX4@28221|Deltaproteobacteria,2MG79@213115|Desulfovibrionales	28221|Deltaproteobacteria	NT	SMART chemotaxis sensory transducer	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	4HB_MCP_1,HAMP,HBM,MCPsignal
HKD2_k127_8856326_20	96561.Dole_0049	5.896e-22	105.0	COG2204@1|root,COG2204@2|Bacteria	2|Bacteria	T	phosphorelay signal transduction system	-	-	-	ko:K13599	ko02020,map02020	M00498	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	DUF4388,HATPase_c,HTH_8,HisKA,Response_reg,SSF,Sigma54_activat
HKD2_k127_8856326_18	335543.Sfum_1651	1.009e-34	150.0	COG2201@1|root,COG2201@2|Bacteria,1NYTV@1224|Proteobacteria,430RN@68525|delta/epsilon subdivisions,2WVYW@28221|Deltaproteobacteria,2MRZ3@213462|Syntrophobacterales	28221|Deltaproteobacteria	NT	Domain of unknown function (DUF4388)	-	-	3.1.1.61,3.5.1.44	ko:K03412	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	DUF4388,Response_reg
HKD2_k127_8856326_15	1121403.AUCV01000002_gene660	6.974e-45	167.0	COG1403@1|root,COG1403@2|Bacteria,1MWEQ@1224|Proteobacteria,42U6P@68525|delta/epsilon subdivisions,2WQ00@28221|Deltaproteobacteria,2MKG2@213118|Desulfobacterales	28221|Deltaproteobacteria	L	PFAM HNH endonuclease	-	-	-	ko:K07451	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	HNH_5
HKD2_k127_8856326_1	589865.DaAHT2_1269	1.957e-141	462.0	COG0285@1|root,COG0285@2|Bacteria,1MVCH@1224|Proteobacteria,42N08@68525|delta/epsilon subdivisions,2WIW9@28221|Deltaproteobacteria,2MHTY@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Mur ligase middle domain	folC	-	6.3.2.12,6.3.2.17	ko:K11754	ko00790,ko01100,map00790,map01100	M00126,M00841	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2475	Mur_ligase_C,Mur_ligase_M
HKD2_k127_8856326_0	1121403.AUCV01000002_gene658	1.874e-300	939.0	COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,42MKU@68525|delta/epsilon subdivisions,2WJR3@28221|Deltaproteobacteria,2MI3D@213118|Desulfobacterales	28221|Deltaproteobacteria	L	UvrD REP helicase	pcrA	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
HKD2_k127_8856326_16	1121403.AUCV01000002_gene657	1.161e-43	162.0	2CR0D@1|root,32SN5@2|Bacteria,1N181@1224|Proteobacteria,42U36@68525|delta/epsilon subdivisions,2WQW4@28221|Deltaproteobacteria,2MKEU@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8856326_11	1379281.AVAG01000021_gene1115	3.739e-55	210.0	COG1906@1|root,COG1906@2|Bacteria,1RAQQ@1224|Proteobacteria,42QZ0@68525|delta/epsilon subdivisions,2WMXK@28221|Deltaproteobacteria,2M7VJ@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF401)	-	-	-	ko:K09133	-	-	-	-	ko00000	-	-	-	DUF401
HKD2_k127_8856326_6	1121403.AUCV01000002_gene655	1.348e-101	341.0	COG1472@1|root,COG1472@2|Bacteria,1MVAJ@1224|Proteobacteria,42N8K@68525|delta/epsilon subdivisions,2WK5Q@28221|Deltaproteobacteria,2MPXG@213118|Desulfobacterales	28221|Deltaproteobacteria	G	Glycosyl hydrolase family 3 N terminal domain	-	-	3.2.1.52	ko:K01207	ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501	M00628	R00022,R05963,R07809,R07810,R10831	RC00049	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyco_hydro_3
HKD2_k127_8856326_10	1121940.AUDZ01000016_gene89	5.839e-57	204.0	COG2314@1|root,COG2314@2|Bacteria,1RHUU@1224|Proteobacteria,1S694@1236|Gammaproteobacteria,1XPBP@135619|Oceanospirillales	135619|Oceanospirillales	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	TM2
HKD2_k127_8856326_23	56780.SYN_01964	1.773e-14	77.0	COG2921@1|root,COG2921@2|Bacteria,1Q4UZ@1224|Proteobacteria,42X4T@68525|delta/epsilon subdivisions,2WXJS@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Protein of unknown function (DUF493)	-	-	-	ko:K09158	-	-	-	-	ko00000	-	-	-	DUF493
HKD2_k127_8856326_19	1232410.KI421415_gene3082	3.823e-31	126.0	COG1193@1|root,COG1193@2|Bacteria,1NCS6@1224|Proteobacteria,42VGJ@68525|delta/epsilon subdivisions,2WRA6@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	PFAM Smr protein MutS2	-	-	-	-	-	-	-	-	-	-	-	-	Smr
HKD2_k127_8856326_4	177439.DP1936	5.927e-129	430.0	COG0763@1|root,COG0763@2|Bacteria,1MVBI@1224|Proteobacteria,42P35@68525|delta/epsilon subdivisions,2WJFA@28221|Deltaproteobacteria,2MIFD@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxB	GO:0003674,GO:0005488,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008289,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0019637,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	2.4.1.182	ko:K00748	ko00540,ko01100,map00540,map01100	M00060	R04606	RC00005,RC00059	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT19	-	LpxB
HKD2_k127_8856326_3	1121403.AUCV01000002_gene647	2.09e-134	438.0	COG0673@1|root,COG0673@2|Bacteria,1MV7C@1224|Proteobacteria,42NV0@68525|delta/epsilon subdivisions,2WK1Y@28221|Deltaproteobacteria,2MHUD@213118|Desulfobacterales	28221|Deltaproteobacteria	S	PFAM oxidoreductase domain protein	gnnA	-	-	ko:K09949	-	-	-	-	ko00000	-	-	iAF987.Gmet_2352	GFO_IDH_MocA,GFO_IDH_MocA_C
HKD2_k127_8856326_7	1121403.AUCV01000002_gene646	5.387e-101	335.0	COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,42M9C@68525|delta/epsilon subdivisions,2WJ75@28221|Deltaproteobacteria,2MIWW@213118|Desulfobacterales	28221|Deltaproteobacteria	E	ABC transporter	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
HKD2_k127_8856326_12	1121403.AUCV01000002_gene645	1.714e-48	175.0	COG0411@1|root,COG0411@2|Bacteria,1MUTY@1224|Proteobacteria,42NMG@68525|delta/epsilon subdivisions,2WJ48@28221|Deltaproteobacteria,2MITM@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Branched-chain amino acid ATP-binding cassette transporter	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
HKD2_k127_8861295_0	1500893.JQNB01000001_gene3514	4.529e-272	912.0	COG3419@1|root,COG3419@2|Bacteria,1NUAV@1224|Proteobacteria,1RPV3@1236|Gammaproteobacteria,1X5NA@135614|Xanthomonadales	135614|Xanthomonadales	NU	Neisseria PilC beta-propeller domain	-	-	-	-	-	-	-	-	-	-	-	-	Neisseria_PilC
HKD2_k127_8861295_4	177437.HRM2_27660	3.971e-27	120.0	COG4726@1|root,COG4726@2|Bacteria,1NC4I@1224|Proteobacteria,42VGI@68525|delta/epsilon subdivisions,2WS7G@28221|Deltaproteobacteria,2MM9W@213118|Desulfobacterales	28221|Deltaproteobacteria	NU	PilX N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	PilX_N
HKD2_k127_8861295_5	1121403.AUCV01000024_gene3453	1.161e-18	93.0	COG4967@1|root,COG4967@2|Bacteria,1NI49@1224|Proteobacteria	1224|Proteobacteria	NU	type IV pilus modification protein PilV	pilV	-	-	ko:K02671	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	N_methyl
HKD2_k127_8861295_3	1121396.KB893057_gene2528	7.555e-44	171.0	COG4966@1|root,COG4966@2|Bacteria,1N2NR@1224|Proteobacteria,42TRJ@68525|delta/epsilon subdivisions,2WQQ2@28221|Deltaproteobacteria,2MKHU@213118|Desulfobacterales	28221|Deltaproteobacteria	NU	pilus assembly protein PilW	-	-	-	-	-	-	-	-	-	-	-	-	N_methyl,PilW
HKD2_k127_8861295_6	879212.DespoDRAFT_01134	1.225e-13	79.0	COG4970@1|root,COG4970@2|Bacteria,1N85U@1224|Proteobacteria,42WBU@68525|delta/epsilon subdivisions,2WSG1@28221|Deltaproteobacteria,2MMBS@213118|Desulfobacterales	28221|Deltaproteobacteria	NU	Prokaryotic N-terminal methylation motif	-	-	-	ko:K08084	-	-	-	-	ko00000,ko02044	3.A.15.2	-	-	GspH,N_methyl
HKD2_k127_8861295_1	96561.Dole_1777	1.387e-164	530.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2MPSH@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Sigma-54 interaction domain	-	-	-	ko:K07714	ko02020,map02020	M00500	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD2_k127_8861295_2	1167006.UWK_02375	4.362e-92	318.0	COG4191@1|root,COG4191@2|Bacteria,1R9AK@1224|Proteobacteria,42Q2G@68525|delta/epsilon subdivisions,2WM8Y@28221|Deltaproteobacteria,2MI84@213118|Desulfobacterales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
HKD2_k127_8866782_1	1121403.AUCV01000019_gene3307	8.768e-54	203.0	COG0574@1|root,COG3848@1|root,COG0574@2|Bacteria,COG3848@2|Bacteria,1Q33X@1224|Proteobacteria,42YME@68525|delta/epsilon subdivisions,2WTUH@28221|Deltaproteobacteria,2MN39@213118|Desulfobacterales	28221|Deltaproteobacteria	GT	PEP-utilising enzyme, mobile domain	-	-	-	-	-	-	-	-	-	-	-	-	PEP-utilizers,PPDK_N
HKD2_k127_8866782_0	1121456.ATVA01000001_gene3073	1.452e-123	419.0	COG0574@1|root,COG3848@1|root,COG0574@2|Bacteria,COG3848@2|Bacteria,1QFX3@1224|Proteobacteria,42PIP@68525|delta/epsilon subdivisions,2WKWI@28221|Deltaproteobacteria,2MG9J@213115|Desulfovibrionales	28221|Deltaproteobacteria	G	PFAM Pyruvate phosphate dikinase, PEP pyruvate-binding	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PPDK_N
HKD2_k127_8888341_0	926569.ANT_08920	8.521e-117	380.0	COG4974@1|root,COG4974@2|Bacteria,2G6QW@200795|Chloroflexi	200795|Chloroflexi	L	Belongs to the 'phage' integrase family	-	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
HKD2_k127_8888341_1	926569.ANT_08910	3.011e-30	127.0	COG0037@1|root,COG0037@2|Bacteria,2G6AD@200795|Chloroflexi	200795|Chloroflexi	D	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine	tilS	-	2.4.2.8,6.3.4.19	ko:K00760,ko:K04075,ko:K15780	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	-	R00190,R01132,R01229,R02142,R08237,R08238,R08245,R09597	RC00063,RC00122,RC02633,RC02634	ko00000,ko00001,ko01000,ko03016	-	-	-	ATP_bind_3,Pribosyltran,TilS,TilS_C
HKD2_k127_8890752_3	1167006.UWK_02016	7.444e-48	175.0	COG1413@1|root,COG1413@2|Bacteria,1P6NU@1224|Proteobacteria,4332R@68525|delta/epsilon subdivisions,2WXCP@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8890752_1	1121403.AUCV01000025_gene2219	5.54e-79	270.0	COG0457@1|root,COG0457@2|Bacteria,1R438@1224|Proteobacteria,42PQ9@68525|delta/epsilon subdivisions,2WJ0C@28221|Deltaproteobacteria,2MIBG@213118|Desulfobacterales	28221|Deltaproteobacteria	S	PFAM Tetratricopeptide	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_10,TPR_11,TPR_16,TPR_19,TPR_2,TPR_8
HKD2_k127_8890752_0	1167006.UWK_02014	8.4e-144	462.0	COG0196@1|root,COG0196@2|Bacteria,1MV9I@1224|Proteobacteria,42MV7@68525|delta/epsilon subdivisions,2WJTU@28221|Deltaproteobacteria,2MHYE@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Belongs to the ribF family	ribF	-	2.7.1.26,2.7.7.2	ko:K11753	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00161,R00549	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_syn,Flavokinase
HKD2_k127_8890752_2	349521.HCH_00128	1.378e-73	255.0	28NH4@1|root,2ZBJ2@2|Bacteria,1N1V3@1224|Proteobacteria,1SPNH@1236|Gammaproteobacteria,1XPED@135619|Oceanospirillales	135619|Oceanospirillales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8890752_4	177437.HRM2_13910	5.427e-22	98.0	COG0490@1|root,COG1226@1|root,COG4651@1|root,COG0490@2|Bacteria,COG1226@2|Bacteria,COG4651@2|Bacteria,1MV34@1224|Proteobacteria,42MEM@68525|delta/epsilon subdivisions,2WK23@28221|Deltaproteobacteria,2MHVK@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family	-	-	-	ko:K03455	-	-	-	-	ko00000	2.A.37	-	-	Na_H_Exchanger,TrkA_C,TrkA_N
HKD2_k127_8946475_2	1121403.AUCV01000046_gene1089	5.206e-59	218.0	COG0664@1|root,COG1413@1|root,COG0664@2|Bacteria,COG1413@2|Bacteria,1RJYT@1224|Proteobacteria,42T0W@68525|delta/epsilon subdivisions,2WP8U@28221|Deltaproteobacteria,2MK7T@213118|Desulfobacterales	28221|Deltaproteobacteria	T	cyclic nucleotide-binding	-	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	HEAT_2,PilZ,cNMP_binding
HKD2_k127_8946475_3	1210884.HG799462_gene8379	1.912e-18	99.0	COG3209@1|root,COG3209@2|Bacteria	2|Bacteria	M	self proteolysis	wapA	-	-	-	-	-	-	-	-	-	-	-	NHL,RHS_repeat
HKD2_k127_8946475_1	159087.Daro_0241	2.722e-78	271.0	COG3221@1|root,COG3221@2|Bacteria,1R4SK@1224|Proteobacteria,2VQN6@28216|Betaproteobacteria,2KW7Y@206389|Rhodocyclales	206389|Rhodocyclales	P	ABC transporter, phosphonate, periplasmic substrate-binding protein	-	-	-	ko:K02044	ko02010,map02010	M00223	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.9	-	-	Phosphonate-bd
HKD2_k127_8946475_0	404380.Gbem_2137	7.795e-89	313.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MC4@68525|delta/epsilon subdivisions,2WIZU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg,dCache_1
HKD2_k127_8958679_0	439235.Dalk_2217	2.225e-77	282.0	COG0457@1|root,COG0457@2|Bacteria,1NFQW@1224|Proteobacteria,42MT2@68525|delta/epsilon subdivisions,2WKWA@28221|Deltaproteobacteria,2MJFK@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Tetratricopeptide TPR_2 repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_11,TPR_16,TPR_2,TPR_4,TPR_8
HKD2_k127_8958679_1	1121403.AUCV01000006_gene400	7.893e-52	186.0	COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,42MA7@68525|delta/epsilon subdivisions,2WIPC@28221|Deltaproteobacteria,2MI8B@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Acts as a magnesium transporter	-	-	-	ko:K06213	-	-	-	-	ko00000,ko02000	1.A.26.1	-	-	CBS,MgtE,MgtE_N
HKD2_k127_8959060_6	1434325.AZQN01000001_gene270	1.876e-29	130.0	28JXC@1|root,2Z8EX@2|Bacteria,4NF7D@976|Bacteroidetes,47M9Z@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8959060_7	1121403.AUCV01000028_gene2446	2.148e-28	124.0	COG2214@1|root,COG2214@2|Bacteria	2|Bacteria	O	Heat shock protein DnaJ domain protein	cysZ	-	-	ko:K06203,ko:K07126	-	-	-	-	ko00000	-	-	-	DnaJ,Sel1
HKD2_k127_8959060_3	1121403.AUCV01000028_gene2447	1.068e-71	247.0	COG0344@1|root,COG0344@2|Bacteria,1RD4Z@1224|Proteobacteria,42QQP@68525|delta/epsilon subdivisions,2WMZE@28221|Deltaproteobacteria,2MK3Y@213118|Desulfobacterales	28221|Deltaproteobacteria	I	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP	plsY	-	2.3.1.15	ko:K08591	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	G3P_acyltransf
HKD2_k127_8959060_2	1121403.AUCV01000028_gene2448	1.413e-86	295.0	COG0727@1|root,COG0727@2|Bacteria	2|Bacteria	S	metal cluster binding	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8959060_4	1121403.AUCV01000028_gene2449	3.183e-70	241.0	COG0242@1|root,COG0242@2|Bacteria,1RA2P@1224|Proteobacteria,42RFN@68525|delta/epsilon subdivisions,2WP25@28221|Deltaproteobacteria,2MJU0@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions	def	-	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	Pep_deformylase
HKD2_k127_8959060_1	1121403.AUCV01000028_gene2450	2.677e-119	397.0	COG0223@1|root,COG0223@2|Bacteria,1MU4Q@1224|Proteobacteria,42M3E@68525|delta/epsilon subdivisions,2WKMK@28221|Deltaproteobacteria,2MI0Y@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus	fmt	-	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	-	Formyl_trans_C,Formyl_trans_N
HKD2_k127_8959060_0	589865.DaAHT2_0363	2.845e-122	418.0	COG1641@1|root,COG1641@2|Bacteria,1MUKU@1224|Proteobacteria,42MHQ@68525|delta/epsilon subdivisions,2WJAC@28221|Deltaproteobacteria,2MHXQ@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Belongs to the LarC family	-	-	4.99.1.12	ko:K09121	-	-	-	-	ko00000,ko01000	-	-	-	DUF111
HKD2_k127_8959060_5	1167006.UWK_00826	3.246e-55	196.0	COG1267@1|root,COG1267@2|Bacteria,1MZJA@1224|Proteobacteria,42U6G@68525|delta/epsilon subdivisions,2WQDR@28221|Deltaproteobacteria,2MKIR@213118|Desulfobacterales	28221|Deltaproteobacteria	I	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)	pgpA	-	3.1.3.27	ko:K01095	ko00564,ko01100,map00564,map01100	-	R02029	RC00017	ko00000,ko00001,ko01000	-	-	iAF987.Gmet_0195	PgpA
HKD2_k127_8975209_18	1121403.AUCV01000017_gene4463	1.797e-17	85.0	COG0834@1|root,COG0834@2|Bacteria,1MV3Q@1224|Proteobacteria,42PQN@68525|delta/epsilon subdivisions,2WKV7@28221|Deltaproteobacteria,2MJFP@213118|Desulfobacterales	28221|Deltaproteobacteria	ET	Bacterial periplasmic substrate-binding proteins	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	SBP_bac_3
HKD2_k127_8975209_11	1167006.UWK_00479	2.539e-49	179.0	2E978@1|root,333FR@2|Bacteria,1NKG1@1224|Proteobacteria,42WUU@68525|delta/epsilon subdivisions,2WTBV@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8975209_7	1485545.JQLW01000011_gene1310	4.717e-91	303.0	COG3647@1|root,COG3647@2|Bacteria,1N7NB@1224|Proteobacteria	1224|Proteobacteria	S	membrane	yjdF	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K08984	-	-	-	-	ko00000	-	-	-	DUF2238
HKD2_k127_8975209_9	1121403.AUCV01000017_gene4468	7.781e-66	233.0	COG0132@1|root,COG0132@2|Bacteria,1RDRK@1224|Proteobacteria,42SQE@68525|delta/epsilon subdivisions	1224|Proteobacteria	H	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring	bioD	GO:0003674,GO:0003824,GO:0004141,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016882,GO:0017144,GO:0018130,GO:0019752,GO:0032787,GO:0034641,GO:0042364,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.3.3	ko:K01935	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03182	RC00868	ko00000,ko00001,ko00002,ko01000	-	-	-	AAA_26
HKD2_k127_8975209_10	1121403.AUCV01000017_gene4470	1.587e-59	219.0	COG4106@1|root,COG4106@2|Bacteria,1NG56@1224|Proteobacteria,43DDZ@68525|delta/epsilon subdivisions,2X8JW@28221|Deltaproteobacteria,2MMEP@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
HKD2_k127_8975209_12	1121403.AUCV01000035_gene3822	5.176e-45	175.0	COG2830@1|root,COG2830@2|Bacteria,1N77V@1224|Proteobacteria,43BDM@68525|delta/epsilon subdivisions,2WY6Z@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Protein of unknown function (DUF452)	-	-	3.1.1.85	ko:K09789	ko00780,ko01100,map00780,map01100	M00572	R09725	RC00460,RC00461	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF452
HKD2_k127_8975209_5	1121403.AUCV01000035_gene3821	4.547e-130	426.0	COG0156@1|root,COG0156@2|Bacteria,1MVVH@1224|Proteobacteria,42MM1@68525|delta/epsilon subdivisions,2WMZK@28221|Deltaproteobacteria,2MPU5@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Aminotransferase class I and II	-	-	2.3.1.47	ko:K00652	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03210,R10124	RC00004,RC00039,RC02725	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
HKD2_k127_8975209_15	1121403.AUCV01000035_gene3820	1.206e-25	108.0	COG1393@1|root,COG1393@2|Bacteria,1NNVX@1224|Proteobacteria,42XJB@68525|delta/epsilon subdivisions,2WT31@28221|Deltaproteobacteria,2MMB9@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Belongs to the ArsC family	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8975209_17	880072.Desac_2767	1.68e-17	89.0	2AKAT@1|root,31B1G@2|Bacteria,1N656@1224|Proteobacteria,42T13@68525|delta/epsilon subdivisions,2WPIE@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8975209_3	589865.DaAHT2_0414	1.385e-172	565.0	COG0784@1|root,COG5002@1|root,COG0784@2|Bacteria,COG5002@2|Bacteria,1NC9X@1224|Proteobacteria,43BSJ@68525|delta/epsilon subdivisions,2X73B@28221|Deltaproteobacteria,2MI6A@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_9,Response_reg
HKD2_k127_8975209_6	765911.Thivi_4465	5.686e-93	323.0	COG0053@1|root,COG0053@2|Bacteria,1MUDS@1224|Proteobacteria,1RNS2@1236|Gammaproteobacteria,1WWQH@135613|Chromatiales	135613|Chromatiales	P	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family	-	-	-	ko:K13283	-	-	-	-	ko00000,ko02000	2.A.4.7.1	-	-	Cation_efflux,ZT_dimer
HKD2_k127_8975209_13	1121403.AUCV01000060_gene3721	1.416e-34	139.0	COG1862@1|root,COG1862@2|Bacteria,1MZT2@1224|Proteobacteria,42V1U@68525|delta/epsilon subdivisions,2WR76@28221|Deltaproteobacteria,2MKVW@213118|Desulfobacterales	28221|Deltaproteobacteria	U	TIGRFAM preprotein translocase, YajC subunit	yajC	-	-	ko:K03210	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	YajC
HKD2_k127_8975209_2	1121403.AUCV01000060_gene3720	1.504e-176	563.0	COG0343@1|root,COG0343@2|Bacteria,1MUCA@1224|Proteobacteria,42M5Y@68525|delta/epsilon subdivisions,2WIMT@28221|Deltaproteobacteria,2MIZI@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)	tgt	-	2.4.2.29	ko:K00773	-	-	R03789,R10209	RC00063	ko00000,ko01000,ko03016	-	-	-	TGT
HKD2_k127_8975209_8	1121403.AUCV01000060_gene3713	1.906e-80	288.0	COG2334@1|root,COG2334@2|Bacteria,1Q18Y@1224|Proteobacteria,42PIW@68525|delta/epsilon subdivisions,2WK5A@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM Aminoglycoside phosphotransferase	-	-	-	-	-	-	-	-	-	-	-	-	APH
HKD2_k127_8975209_14	543728.Vapar_4014	3.65e-31	132.0	COG1694@1|root,COG1694@2|Bacteria,1N02D@1224|Proteobacteria,2VU39@28216|Betaproteobacteria,4AF54@80864|Comamonadaceae	28216|Betaproteobacteria	S	PFAM MazG nucleotide pyrophosphohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	MazG-like
HKD2_k127_8975209_0	1121403.AUCV01000017_gene4541	2.839e-188	599.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,42NB6@68525|delta/epsilon subdivisions,2WIWE@28221|Deltaproteobacteria,2MHQQ@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Belongs to the peptidase S1C family	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
HKD2_k127_8975209_4	706587.Desti_0537	2.27e-136	469.0	COG0784@1|root,COG2202@1|root,COG3852@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG3852@2|Bacteria,1NC9X@1224|Proteobacteria,43BSJ@68525|delta/epsilon subdivisions,2X73B@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,Response_reg
HKD2_k127_8975209_16	65393.PCC7424_2738	4.594e-22	113.0	COG0515@1|root,COG1672@1|root,COG3899@1|root,COG0515@2|Bacteria,COG1672@2|Bacteria,COG3899@2|Bacteria,1G4QT@1117|Cyanobacteria,3KKPT@43988|Cyanothece	1117|Cyanobacteria	KLT	Serine Threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,AAA_35,GAF,GAF_2,HATPase_c,HisKA,PAS_4,Pkinase
HKD2_k127_8975209_1	1167006.UWK_01346	3.213e-187	595.0	COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,42MBP@68525|delta/epsilon subdivisions,2WJAJ@28221|Deltaproteobacteria,2MHTN@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,Pyr_redox_dim
HKD2_k127_898288_1	237609.PSAKL28_25280	3.053e-99	332.0	COG4623@1|root,COG4623@2|Bacteria,1MWDS@1224|Proteobacteria,1RM8W@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella	mltF2	GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944	-	ko:K18691	-	-	-	-	ko00000,ko01000,ko01011	-	-	-	SBP_bac_3,SLT
HKD2_k127_898288_3	1121403.AUCV01000005_gene265	5.151e-50	185.0	COG0779@1|root,COG0779@2|Bacteria,1RDP2@1224|Proteobacteria,42THF@68525|delta/epsilon subdivisions,2WQ0W@28221|Deltaproteobacteria,2MKTS@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Required for maturation of 30S ribosomal subunits	rimP	-	-	ko:K09748	-	-	-	-	ko00000,ko03009	-	-	-	DUF150,DUF150_C
HKD2_k127_898288_0	1121403.AUCV01000005_gene266	1.068e-207	653.0	COG0195@1|root,COG0195@2|Bacteria,1MWT7@1224|Proteobacteria,42MUW@68525|delta/epsilon subdivisions,2WIXI@28221|Deltaproteobacteria,2MHW6@213118|Desulfobacterales	28221|Deltaproteobacteria	K	Participates in both transcription termination and antitermination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	HHH_5,KH_5,NusA_N,S1
HKD2_k127_898288_4	1379281.AVAG01000112_gene243	3.161e-07	54.0	COG2740@1|root,COG2740@2|Bacteria	2|Bacteria	K	Nucleic-acid-binding protein implicated in transcription termination	ylxR	-	-	ko:K02600,ko:K07742	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	DUF448
HKD2_k127_898288_2	589865.DaAHT2_1880	1.183e-85	303.0	COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,42M5Q@68525|delta/epsilon subdivisions,2WIIX@28221|Deltaproteobacteria,2MIGT@213118|Desulfobacterales	28221|Deltaproteobacteria	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,IF-2,IF2_N
HKD2_k127_9018600_0	1163671.JAGI01000002_gene3195	5.474e-103	351.0	COG1134@1|root,COG1134@2|Bacteria,1TQKK@1239|Firmicutes,24A5V@186801|Clostridia,36DY5@31979|Clostridiaceae	186801|Clostridia	GM	ABC-type polysaccharide polyol phosphate transport system, ATPase component	tagH	-	3.6.3.40	ko:K01990,ko:K09691,ko:K09693	ko02010,map02010	M00250,M00251,M00254	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.103,3.A.1.104	-	-	ABC_tran,Wzt_C
HKD2_k127_9018600_1	118168.MC7420_3577	4.626e-08	58.0	COG1215@1|root,COG1216@1|root,COG2227@1|root,COG1215@2|Bacteria,COG1216@2|Bacteria,COG2227@2|Bacteria,1GQBE@1117|Cyanobacteria,1H7DT@1150|Oscillatoriales	1117|Cyanobacteria	M	glycosyl transferase family 2	-	-	-	ko:K20444	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.1.3	GT2,GT4	-	Glycos_transf_2,RgpF,TPR_1,TPR_11,TPR_16,TPR_2,TPR_7,TPR_8
HKD2_k127_9030918_3	1167006.UWK_01610	8.429e-160	521.0	COG1232@1|root,COG1232@2|Bacteria,1R0KQ@1224|Proteobacteria,42NBG@68525|delta/epsilon subdivisions,2WKMN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX	hemY	-	1.3.3.15,1.3.3.4	ko:K00231	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03222,R04178	RC00885	ko00000,ko00001,ko00002,ko01000	-	-	-	Amino_oxidase
HKD2_k127_9030918_1	1121403.AUCV01000021_gene3554	5.166e-171	547.0	COG0593@1|root,COG0593@2|Bacteria,1MU5H@1224|Proteobacteria,42MA0@68525|delta/epsilon subdivisions,2WJAT@28221|Deltaproteobacteria,2MHNX@213118|Desulfobacterales	28221|Deltaproteobacteria	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids	dnaA	-	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA,Bac_DnaA_C,DnaA_N
HKD2_k127_9030918_4	589865.DaAHT2_2000	6.783e-66	232.0	COG1040@1|root,COG1040@2|Bacteria,1RHAV@1224|Proteobacteria,42SV9@68525|delta/epsilon subdivisions,2WPXX@28221|Deltaproteobacteria,2MJUD@213118|Desulfobacterales	28221|Deltaproteobacteria	S	PFAM Phosphoribosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Pribosyltran
HKD2_k127_9030918_0	589865.DaAHT2_1237	0.0	1106.0	COG2838@1|root,COG2838@2|Bacteria,1MV6Q@1224|Proteobacteria,42MY0@68525|delta/epsilon subdivisions,2WM7X@28221|Deltaproteobacteria,2MIGK@213118|Desulfobacterales	28221|Deltaproteobacteria	C	isocitrate dehydrogenase, NADP-dependent, monomeric type	icd	-	1.1.1.42	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00740	R00267,R00268,R01899	RC00001,RC00084,RC00114,RC00626,RC02801	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	IDH
HKD2_k127_9030918_2	1217718.ALOU01000040_gene185	5.55e-164	542.0	COG1752@1|root,COG4775@1|root,COG1752@2|Bacteria,COG4775@2|Bacteria,1MUM9@1224|Proteobacteria,2VJRI@28216|Betaproteobacteria	28216|Betaproteobacteria	M	surface antigen variable number repeat protein	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Bac_surface_Ag,POTRA,Patatin
HKD2_k127_9040491_0	1121403.AUCV01000077_gene4330	3.064e-296	912.0	COG0056@1|root,COG0056@2|Bacteria,1MUG7@1224|Proteobacteria,42MVX@68525|delta/epsilon subdivisions,2WIK7@28221|Deltaproteobacteria,2MIHR@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	atpA	-	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
HKD2_k127_9040491_5	1121403.AUCV01000077_gene4331	5.259e-80	270.0	COG0712@1|root,COG0712@2|Bacteria,1MVRH@1224|Proteobacteria,42U68@68525|delta/epsilon subdivisions,2WQJS@28221|Deltaproteobacteria,2MJKI@213118|Desulfobacterales	28221|Deltaproteobacteria	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpH	-	-	ko:K02113	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	OSCP
HKD2_k127_9040491_6	1121403.AUCV01000077_gene4332	2.308e-56	206.0	COG0711@1|root,COG0711@2|Bacteria,1N97K@1224|Proteobacteria,42VYP@68525|delta/epsilon subdivisions,2WR6T@28221|Deltaproteobacteria,2MK1E@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)	atpF	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045263,GO:0045264,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_B
HKD2_k127_9040491_7	1121403.AUCV01000077_gene4333	1.141e-39	151.0	COG0711@1|root,COG0711@2|Bacteria,1NA9K@1224|Proteobacteria,42VN2@68525|delta/epsilon subdivisions,2WR8C@28221|Deltaproteobacteria,2MKBA@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)	atpX	-	-	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_B
HKD2_k127_9040491_3	1121403.AUCV01000077_gene4334	3.246e-110	366.0	COG0451@1|root,COG0451@2|Bacteria,1P603@1224|Proteobacteria,42NGH@68525|delta/epsilon subdivisions,2WKS6@28221|Deltaproteobacteria,2MI68@213118|Desulfobacterales	28221|Deltaproteobacteria	M	3-beta hydroxysteroid dehydrogenase isomerase	-	-	1.1.1.394,1.1.1.412	ko:K21271,ko:K22320	-	-	-	-	ko00000,ko01000	-	-	-	3Beta_HSD
HKD2_k127_9040491_1	1121403.AUCV01000019_gene3239	4.972e-193	617.0	COG0318@1|root,COG0318@2|Bacteria,1R5I6@1224|Proteobacteria,42MKC@68525|delta/epsilon subdivisions,2WK3U@28221|Deltaproteobacteria,2MI82@213118|Desulfobacterales	28221|Deltaproteobacteria	IQ	AMP-binding enzyme	-	-	6.1.3.1	ko:K22319	-	-	-	-	ko00000,ko01000	-	-	-	AMP-binding
HKD2_k127_9040491_4	1121403.AUCV01000019_gene3240	5.331e-91	322.0	COG0596@1|root,COG0596@2|Bacteria,1MUSF@1224|Proteobacteria,42NM4@68525|delta/epsilon subdivisions,2WJ8H@28221|Deltaproteobacteria,2MJ16@213118|Desulfobacterales	28221|Deltaproteobacteria	S	alpha/beta hydrolase fold	-	-	3.8.1.5	ko:K01563,ko:K22318	ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120	-	R05284,R05367,R05368,R05369,R05370,R07669,R07670	RC01317,RC01340,RC01341,RC02013	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1
HKD2_k127_9040491_2	1121403.AUCV01000019_gene3241	8.622e-163	518.0	COG0332@1|root,COG0332@2|Bacteria,1P9I2@1224|Proteobacteria,42PE7@68525|delta/epsilon subdivisions,2WJZZ@28221|Deltaproteobacteria,2MHMU@213118|Desulfobacterales	28221|Deltaproteobacteria	I	PFAM 3-Oxoacyl- acyl-carrier-protein (ACP) synthase III	fabH-3	-	-	ko:K22317	-	-	-	-	ko00000	-	-	-	ACP_syn_III,ACP_syn_III_C,Thiolase_N
HKD2_k127_9058963_0	1220534.B655_0740	5.911e-107	357.0	arCOG02499@1|root,arCOG10865@1|root,arCOG02499@2157|Archaea,arCOG10865@2157|Archaea	2157|Archaea	S	Periplasmic copper-binding protein (NosD)	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,DUF11,NosD
HKD2_k127_9058963_7	395961.Cyan7425_4227	1.183e-15	81.0	2AJK9@1|root,31A7A@2|Bacteria,1GF48@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9058963_4	1123393.KB891317_gene2209	2.108e-68	233.0	COG0662@1|root,COG0662@2|Bacteria,1QW6S@1224|Proteobacteria	1224|Proteobacteria	G	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HKD2_k127_9058963_1	1167006.UWK_00086	6.553e-90	302.0	COG0689@1|root,COG0689@2|Bacteria,1MVFZ@1224|Proteobacteria,42NEX@68525|delta/epsilon subdivisions,2WJ1Y@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates	rph	GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0019439,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:1901360,GO:1901361,GO:1901575	2.7.7.56	ko:K00989	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RNase_PH,RNase_PH_C
HKD2_k127_9058963_2	161156.JQKW01000006_gene1251	2.573e-84	289.0	2C2QQ@1|root,32RAW@2|Bacteria	2|Bacteria	-	-	omcX	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9058963_3	161156.JQKW01000006_gene1248	9.904e-71	250.0	2C2QQ@1|root,32RFJ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Paired_CXXCH_1
HKD2_k127_9058963_6	1254432.SCE1572_12560	5.029e-26	113.0	COG0346@1|root,COG0346@2|Bacteria,1PY3J@1224|Proteobacteria,4352G@68525|delta/epsilon subdivisions,2WZDE@28221|Deltaproteobacteria,2Z1W6@29|Myxococcales	28221|Deltaproteobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HKD2_k127_9058963_5	880073.Calab_0699	4.338e-64	231.0	COG0642@1|root,COG0642@2|Bacteria,COG2205@2|Bacteria,2NQMI@2323|unclassified Bacteria	2|Bacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF3365,HATPase_c,HisKA,Hpt,Reg_prop,Response_reg,Y_Y_Y
HKD2_k127_9062471_3	713587.THITH_13015	1.052e-17	84.0	COG0294@1|root,COG0294@2|Bacteria,1MUIR@1224|Proteobacteria,1RM8G@1236|Gammaproteobacteria,1WXND@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives	folP	-	2.5.1.15	ko:K00796	ko00790,ko01100,map00790,map01100	M00126,M00841	R03066,R03067	RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
HKD2_k127_9062471_1	1121403.AUCV01000012_gene4104	5.604e-319	986.0	COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,42M4Z@68525|delta/epsilon subdivisions,2WJ0D@28221|Deltaproteobacteria,2MIPH@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
HKD2_k127_9062471_0	1121403.AUCV01000012_gene4103	0.0	1778.0	COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,42MGK@68525|delta/epsilon subdivisions,2WJQH@28221|Deltaproteobacteria,2MHQD@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Carbamoyl-phosphate synthetase large chain oligomerisation	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
HKD2_k127_9062471_2	1121403.AUCV01000012_gene4102	3.982e-83	276.0	COG0505@1|root,COG0505@2|Bacteria,1MUB9@1224|Proteobacteria,42KZG@68525|delta/epsilon subdivisions,2WIQ5@28221|Deltaproteobacteria,2MIKI@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Belongs to the CarA family	carA	-	6.3.5.5	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_sm_chain,GATase
HKD2_k127_9110116_0	484770.UFO1_1587	4.058e-66	236.0	COG4927@1|root,COG4927@2|Bacteria	2|Bacteria	S	Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase	-	-	-	ko:K19200	ko00311,ko01100,ko01130,map00311,map01100,map01130	-	-	-	ko00000,ko00001,ko01002	-	-	-	AAT
HKD2_k127_9110116_1	1235797.C816_00187	4.913e-08	61.0	COG1661@1|root,COG1661@2|Bacteria,1V67W@1239|Firmicutes,24J3Y@186801|Clostridia	186801|Clostridia	S	Domain of unknown function (DUF296)	-	-	-	ko:K06934	-	-	-	-	ko00000	-	-	-	DUF296
HKD2_k127_9124675_12	1094980.Mpsy_1174	4.135e-07	61.0	COG0642@1|root,COG2203@1|root,arCOG02339@1|root,arCOG02376@1|root,arCOG03567@1|root,arCOG02339@2157|Archaea,arCOG02357@2157|Archaea,arCOG02376@2157|Archaea,arCOG03567@2157|Archaea,arCOG07619@2157|Archaea,2Y7TB@28890|Euryarchaeota,2NBNI@224756|Methanomicrobia	28890|Euryarchaeota	T	GAF domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HAMP,HATPase_c,HisKA,PAS_9,sCache_3_3
HKD2_k127_9124675_9	177439.DP0721	3.294e-37	156.0	COG0526@1|root,COG0526@2|Bacteria,1NJN4@1224|Proteobacteria,42WXI@68525|delta/epsilon subdivisions,2WTEY@28221|Deltaproteobacteria	28221|Deltaproteobacteria	CO	COG0526, thiol-disulfide isomerase and thioredoxins	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9124675_7	1121403.AUCV01000005_gene240	3.277e-51	183.0	COG0537@1|root,COG0537@2|Bacteria,1RDCJ@1224|Proteobacteria,42SEH@68525|delta/epsilon subdivisions,2WQWW@28221|Deltaproteobacteria,2MPV7@213118|Desulfobacterales	28221|Deltaproteobacteria	FG	Scavenger mRNA decapping enzyme C-term binding	hinT	-	-	ko:K02503	-	-	-	-	ko00000,ko04147	-	-	-	HIT
HKD2_k127_9124675_2	1121403.AUCV01000005_gene242	2.479e-171	549.0	COG1061@1|root,COG1061@2|Bacteria,1QWMJ@1224|Proteobacteria,42NXF@68525|delta/epsilon subdivisions,2WJWA@28221|Deltaproteobacteria,2MHPY@213118|Desulfobacterales	28221|Deltaproteobacteria	L	type III restriction protein res subunit	-	-	-	-	-	-	-	-	-	-	-	-	Helicase_C,ResIII
HKD2_k127_9124675_8	1121403.AUCV01000004_gene2070	4.11e-40	156.0	COG1547@1|root,COG1547@2|Bacteria,1NFSR@1224|Proteobacteria,42W5I@68525|delta/epsilon subdivisions,2WSD9@28221|Deltaproteobacteria,2MM1A@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF309)	-	-	-	-	-	-	-	-	-	-	-	-	DUF309
HKD2_k127_9124675_0	1121403.AUCV01000005_gene243	0.0	1022.0	COG1217@1|root,COG1217@2|Bacteria,1MV5Q@1224|Proteobacteria,42M3S@68525|delta/epsilon subdivisions,2WJVZ@28221|Deltaproteobacteria,2MIT4@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Elongation factor Tu domain 2	typA	-	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2
HKD2_k127_9124675_4	1121403.AUCV01000005_gene245	1.892e-56	201.0	COG1051@1|root,COG1051@2|Bacteria,1QUM0@1224|Proteobacteria,42SY6@68525|delta/epsilon subdivisions,2WP3N@28221|Deltaproteobacteria,2MNMX@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Belongs to the Nudix hydrolase family	-	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX
HKD2_k127_9124675_3	1121403.AUCV01000013_gene4008	1.192e-102	349.0	COG5492@1|root,COG5492@2|Bacteria,1QY8X@1224|Proteobacteria,43CAR@68525|delta/epsilon subdivisions,2X7M8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9124675_1	1121403.AUCV01000003_gene1860	6.741e-205	664.0	COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,42MFH@68525|delta/epsilon subdivisions,2WIRW@28221|Deltaproteobacteria,2MIJ9@213118|Desulfobacterales	28221|Deltaproteobacteria	KT	Bacterial regulatory protein, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,PAS,PAS_4,PAS_9,Sigma54_activat
HKD2_k127_9124675_5	555779.Dthio_PD3346	4.846e-56	203.0	COG0642@1|root,COG2202@1|root,COG5002@1|root,COG0642@2|Bacteria,COG2202@2|Bacteria,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,42NK9@68525|delta/epsilon subdivisions,2X7E0@28221|Deltaproteobacteria,2MHE4@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	PFAM ATP-binding region ATPase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF3365,HATPase_c,HisKA,Hpt,PAS_3,PAS_4,PAS_9,Response_reg
HKD2_k127_9140910_2	1500257.JQNM01000008_gene1335	1.334e-32	143.0	COG1670@1|root,COG1670@2|Bacteria,1RF8W@1224|Proteobacteria,2U707@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_3
HKD2_k127_9140910_1	335543.Sfum_1473	6.629e-156	501.0	COG0282@1|root,COG0282@2|Bacteria,1MW61@1224|Proteobacteria,42MJA@68525|delta/epsilon subdivisions,2WJBJ@28221|Deltaproteobacteria,2MR0D@213462|Syntrophobacterales	28221|Deltaproteobacteria	F	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction	ackA	-	2.7.2.1	ko:K00925	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00315,R01353	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetate_kinase
HKD2_k127_9140910_0	706587.Desti_4396	3.593e-230	724.0	COG0280@1|root,COG0857@1|root,COG0280@2|Bacteria,COG0857@2|Bacteria,1QTS5@1224|Proteobacteria,42MPY@68525|delta/epsilon subdivisions,2WJ2V@28221|Deltaproteobacteria,2MRI7@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	phosphate acetyltransferase	pta	-	2.3.1.8	ko:K00625,ko:K13788	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00230,R00921	RC00004,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_1035	AAA_26,DRTGG,PTA_PTB
HKD2_k127_9155519_3	1121403.AUCV01000046_gene1089	9.651e-24	112.0	COG0664@1|root,COG1413@1|root,COG0664@2|Bacteria,COG1413@2|Bacteria,1RJYT@1224|Proteobacteria,42T0W@68525|delta/epsilon subdivisions,2WP8U@28221|Deltaproteobacteria,2MK7T@213118|Desulfobacterales	28221|Deltaproteobacteria	T	cyclic nucleotide-binding	-	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	HEAT_2,PilZ,cNMP_binding
HKD2_k127_9155519_2	1121440.AUMA01000003_gene3004	7.628e-49	181.0	COG0424@1|root,COG0424@2|Bacteria,1RH6H@1224|Proteobacteria,42SR7@68525|delta/epsilon subdivisions,2WP65@28221|Deltaproteobacteria,2MBIV@213115|Desulfovibrionales	28221|Deltaproteobacteria	D	PFAM Maf family protein	maf	-	-	ko:K06287	-	-	-	-	ko00000	-	-	-	Maf
HKD2_k127_9155519_1	1167006.UWK_03556	4.734e-71	250.0	COG0101@1|root,COG0101@2|Bacteria,1MUYI@1224|Proteobacteria,42RTC@68525|delta/epsilon subdivisions,2WNQ6@28221|Deltaproteobacteria,2MJMQ@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs	truA	GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016853,GO:0016866,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360	5.4.99.12	ko:K06173	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PseudoU_synth_1
HKD2_k127_9155519_0	1121403.AUCV01000046_gene1094	2.089e-158	507.0	COG0002@1|root,COG0002@2|Bacteria,1MVJ6@1224|Proteobacteria,42MDN@68525|delta/epsilon subdivisions,2WINX@28221|Deltaproteobacteria,2MI9X@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde	argC	-	1.2.1.38	ko:K00145	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R03443	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
HKD2_k127_9197570_3	489825.LYNGBM3L_21370	3.502e-54	199.0	COG2954@1|root,COG2954@2|Bacteria,1G5NQ@1117|Cyanobacteria,1HB3Z@1150|Oscillatoriales	1117|Cyanobacteria	S	PFAM CYTH domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	CYTH
HKD2_k127_9197570_2	1167006.UWK_02178	2.664e-72	256.0	COG2935@1|root,COG2935@2|Bacteria,1MW62@1224|Proteobacteria,42N66@68525|delta/epsilon subdivisions,2WQ1W@28221|Deltaproteobacteria,2MNUF@213118|Desulfobacterales	28221|Deltaproteobacteria	O	May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate	ate	-	2.3.2.29	ko:K21420	-	-	R11547,R11548	RC00064	ko00000,ko01000	-	-	-	ATE_C,ATE_N
HKD2_k127_9197570_0	1249627.D779_0738	3.539e-165	546.0	COG1404@1|root,COG1404@2|Bacteria,1RC5K@1224|Proteobacteria,1S3I9@1236|Gammaproteobacteria,1WXY7@135613|Chromatiales	135613|Chromatiales	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
HKD2_k127_9197570_1	251221.35211841	1.282e-80	286.0	COG1404@1|root,COG1404@2|Bacteria,1G8UV@1117|Cyanobacteria	1117|Cyanobacteria	O	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8,VCBS
HKD2_k127_9209251_3	1121403.AUCV01000026_gene2325	6.567e-152	485.0	COG0016@1|root,COG0016@2|Bacteria,1MVD7@1224|Proteobacteria,42MB0@68525|delta/epsilon subdivisions,2WJ42@28221|Deltaproteobacteria,2MI3B@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily	pheS	GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iAF987.Gmet_1415	Phe_tRNA-synt_N,tRNA-synt_2d
HKD2_k127_9209251_7	1121403.AUCV01000026_gene2324	4.495e-51	183.0	COG0292@1|root,COG0292@2|Bacteria,1RGU2@1224|Proteobacteria,42REF@68525|delta/epsilon subdivisions,2WQ4F@28221|Deltaproteobacteria,2MK8U@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit	rplT	GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015934,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904	-	ko:K02887	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L20
HKD2_k127_9209251_10	338963.Pcar_1420	2.884e-20	92.0	COG0291@1|root,COG0291@2|Bacteria,1QDQ4@1224|Proteobacteria,42VSG@68525|delta/epsilon subdivisions,2WREY@28221|Deltaproteobacteria,43SRN@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Ribosomal protein L35	rpmI	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02916	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L35p
HKD2_k127_9209251_6	1121403.AUCV01000026_gene2323	2.178e-79	273.0	COG0290@1|root,COG0290@2|Bacteria,1RDD2@1224|Proteobacteria,42RHA@68525|delta/epsilon subdivisions,2WNQW@28221|Deltaproteobacteria,2MJW2@213118|Desulfobacterales	28221|Deltaproteobacteria	J	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins	infC	GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0006996,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022411,GO:0032790,GO:0032984,GO:0032988,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008	-	ko:K02520	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	IF3_C,IF3_N
HKD2_k127_9209251_0	1121403.AUCV01000026_gene2322	0.0	1065.0	COG0441@1|root,COG0441@2|Bacteria,1MUP2@1224|Proteobacteria,42M20@68525|delta/epsilon subdivisions,2WJ2N@28221|Deltaproteobacteria,2MI0Z@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD
HKD2_k127_9209251_12	1121403.AUCV01000026_gene2322	1.569e-05	47.0	COG0441@1|root,COG0441@2|Bacteria,1MUP2@1224|Proteobacteria,42M20@68525|delta/epsilon subdivisions,2WJ2N@28221|Deltaproteobacteria,2MI0Z@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD
HKD2_k127_9209251_5	1121403.AUCV01000026_gene2321	7.413e-84	282.0	COG0353@1|root,COG0353@2|Bacteria,1MV9Q@1224|Proteobacteria,42QZJ@68525|delta/epsilon subdivisions,2WNCH@28221|Deltaproteobacteria,2MIIY@213118|Desulfobacterales	28221|Deltaproteobacteria	L	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO	recR	-	-	ko:K06187	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecR,Toprim_4
HKD2_k127_9209251_9	1304885.AUEY01000073_gene1472	1.967e-30	123.0	COG0718@1|root,COG0718@2|Bacteria,1RGZD@1224|Proteobacteria,42TGQ@68525|delta/epsilon subdivisions,2WQ6R@28221|Deltaproteobacteria,2MK5K@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection	-	-	-	ko:K09747	-	-	-	-	ko00000	-	-	-	YbaB_DNA_bd
HKD2_k127_9209251_2	1121403.AUCV01000026_gene2319	5.013e-176	576.0	COG2812@1|root,COG2812@2|Bacteria,1MVCK@1224|Proteobacteria,42M09@68525|delta/epsilon subdivisions,2WJ1G@28221|Deltaproteobacteria,2MHZQ@213118|Desulfobacterales	28221|Deltaproteobacteria	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity	dnaX	-	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNA_pol3_gamma3
HKD2_k127_9209251_8	589865.DaAHT2_0309	8.845e-50	183.0	COG0590@1|root,COG0590@2|Bacteria,1RGU0@1224|Proteobacteria,42TVP@68525|delta/epsilon subdivisions,2WQ7U@28221|Deltaproteobacteria,2MK74@213118|Desulfobacterales	28221|Deltaproteobacteria	FJ	Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)	tadA	-	3.5.4.33	ko:K11991	-	-	R10223	RC00477	ko00000,ko01000,ko03016	-	-	-	MafB19-deam
HKD2_k127_9209251_1	1121403.AUCV01000013_gene3898	2.184e-177	567.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2MIB8@213118|Desulfobacterales	28221|Deltaproteobacteria	T	response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD2_k127_9209251_4	1121403.AUCV01000013_gene3900	1.723e-136	452.0	COG4783@1|root,COG4783@2|Bacteria,1MVFV@1224|Proteobacteria,42MBR@68525|delta/epsilon subdivisions,2WJ0Z@28221|Deltaproteobacteria,2MHRK@213118|Desulfobacterales	28221|Deltaproteobacteria	S	PFAM peptidase	-	-	-	-	-	-	-	-	-	-	-	iAF987.Gmet_1238	Peptidase_M48,TPR_14,TPR_16,TPR_19
HKD2_k127_9209251_11	1082705.JIBP01000017_gene848	2.886e-13	75.0	COG1123@1|root,COG4172@2|Bacteria,1MU09@1224|Proteobacteria,1RMEI@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Belongs to the ABC transporter superfamily	yejF	GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006857,GO:0008144,GO:0008150,GO:0015399,GO:0015405,GO:0015833,GO:0015893,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0035672,GO:0036094,GO:0042221,GO:0042493,GO:0042623,GO:0042626,GO:0042884,GO:0042886,GO:0042891,GO:0043167,GO:0043168,GO:0043492,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K13896	ko02010,map02010	M00349	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.21,3.A.1.5.24	-	-	ABC_tran,oligo_HPY
HKD2_k127_9230632_7	1121413.JMKT01000011_gene2376	1.357e-18	87.0	COG0835@1|root,COG0835@2|Bacteria,1RAH1@1224|Proteobacteria,42SH0@68525|delta/epsilon subdivisions,2WPFU@28221|Deltaproteobacteria,2MBI8@213115|Desulfovibrionales	28221|Deltaproteobacteria	NT	PFAM CheW domain protein	cheW34H-1	-	-	ko:K03408	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheW
HKD2_k127_9230632_6	1499967.BAYZ01000079_gene888	5.796e-24	108.0	COG0664@1|root,COG0664@2|Bacteria	2|Bacteria	T	cyclic nucleotide binding	-	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	cNMP_binding
HKD2_k127_9230632_4	1121035.AUCH01000006_gene711	3.653e-39	150.0	COG0818@1|root,COG0818@2|Bacteria,1N67A@1224|Proteobacteria,2W2TT@28216|Betaproteobacteria,2KYVA@206389|Rhodocyclales	206389|Rhodocyclales	M	Prokaryotic diacylglycerol kinase	-	-	-	-	-	-	-	-	-	-	-	-	DAGK_prokar
HKD2_k127_9230632_5	472759.Nhal_1586	1.189e-26	117.0	COG0671@1|root,COG0671@2|Bacteria,1RDK3@1224|Proteobacteria,1SG4A@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	Acid phosphatase homologues	-	-	3.1.3.27,3.1.3.4,3.1.3.81,3.6.1.27	ko:K01096,ko:K19302	ko00550,ko00564,ko01100,map00550,map00564,map01100	-	R02029,R05627	RC00002,RC00017	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2
HKD2_k127_9230632_0	1121403.AUCV01000007_gene1226	1.358e-205	651.0	COG1160@1|root,COG1160@2|Bacteria,1MU9S@1224|Proteobacteria,42M3N@68525|delta/epsilon subdivisions,2WISS@28221|Deltaproteobacteria,2MHQH@213118|Desulfobacterales	28221|Deltaproteobacteria	S	GTPase that plays an essential role in the late steps of ribosome biogenesis	der	-	-	ko:K03977	-	-	-	-	ko00000,ko03009	-	-	-	KH_dom-like,MMR_HSR1
HKD2_k127_9230632_2	589865.DaAHT2_0856	1.42e-80	285.0	COG3178@1|root,COG3178@2|Bacteria,1MXCH@1224|Proteobacteria,42N6V@68525|delta/epsilon subdivisions,2WIQC@28221|Deltaproteobacteria,2MI45@213118|Desulfobacterales	28221|Deltaproteobacteria	JM	PFAM aminoglycoside phosphotransferase	-	-	2.7.1.221	ko:K07102	ko00520,ko01100,map00520,map01100	-	R08968,R11024	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	APH,NTP_transferase
HKD2_k127_9230632_1	1167006.UWK_02376	2.392e-161	527.0	COG0685@1|root,COG0685@2|Bacteria,1NB3G@1224|Proteobacteria,42P1W@68525|delta/epsilon subdivisions,2WKDD@28221|Deltaproteobacteria,2MJ0X@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Methylene-tetrahydrofolate reductase C terminal	-	-	1.5.1.20	ko:K00297	ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523	M00377	R01224,R07168	RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	MTHFR,MTHFR_C
HKD2_k127_9230632_3	1167006.UWK_00712	1.974e-56	199.0	28NS9@1|root,2ZBRA@2|Bacteria,1RB6V@1224|Proteobacteria,42QVJ@68525|delta/epsilon subdivisions,2WMXS@28221|Deltaproteobacteria,2MNDY@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9233000_5	443143.GM18_4076	1.04e-31	136.0	COG4269@1|root,COG4269@2|Bacteria	2|Bacteria	T	membrane	yjgN	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DUF898
HKD2_k127_9233000_6	1167006.UWK_01622	3.155e-21	96.0	COG1872@1|root,COG1872@2|Bacteria,1MZ4E@1224|Proteobacteria,42VE5@68525|delta/epsilon subdivisions,2WR8T@28221|Deltaproteobacteria,2MM5T@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Belongs to the UPF0235 family	-	-	-	ko:K09131	-	-	-	-	ko00000	-	-	-	DUF167
HKD2_k127_9233000_4	1121403.AUCV01000032_gene2898	3.884e-37	143.0	COG0762@1|root,COG0762@2|Bacteria,1QDB9@1224|Proteobacteria,42VCU@68525|delta/epsilon subdivisions,2WRHX@28221|Deltaproteobacteria,2MKPA@213118|Desulfobacterales	28221|Deltaproteobacteria	S	YGGT family	-	-	-	ko:K02221	-	-	-	-	ko00000,ko02044	-	-	-	YGGT
HKD2_k127_9233000_0	1121403.AUCV01000032_gene2897	1.602e-291	917.0	COG0143@1|root,COG0143@2|Bacteria,1MUBY@1224|Proteobacteria,42N1K@68525|delta/epsilon subdivisions,2WIT6@28221|Deltaproteobacteria,2MHP4@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g,tRNA_bind
HKD2_k127_9233000_1	1121403.AUCV01000032_gene2896	6.638e-98	330.0	COG1774@1|root,COG1774@2|Bacteria,1MZBX@1224|Proteobacteria,42NE3@68525|delta/epsilon subdivisions,2WK98@28221|Deltaproteobacteria,2MHSJ@213118|Desulfobacterales	28221|Deltaproteobacteria	S	PFAM PSP1 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PSP1
HKD2_k127_9233000_2	1121403.AUCV01000032_gene2895	3.653e-83	287.0	COG2812@1|root,COG2812@2|Bacteria,1QVB3@1224|Proteobacteria,42SBC@68525|delta/epsilon subdivisions,2WPCK@28221|Deltaproteobacteria,2MKCG@213118|Desulfobacterales	28221|Deltaproteobacteria	L	TIGRFAM DNA polymerase III, delta	holB	-	2.7.7.7	ko:K02341	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNApol3-delta_C
HKD2_k127_9233000_3	1121403.AUCV01000032_gene2894	1.493e-53	192.0	COG3481@1|root,COG3481@2|Bacteria,1NH0C@1224|Proteobacteria,42Q7X@68525|delta/epsilon subdivisions,2WJW2@28221|Deltaproteobacteria,2MICY@213118|Desulfobacterales	28221|Deltaproteobacteria	S	nucleic acid binding OB-fold tRNA helicase-type	yhaM	-	-	ko:K03698	-	-	-	-	ko00000,ko01000,ko03019	-	-	-	HD,tRNA_anti-codon
HKD2_k127_9238220_1	1167006.UWK_00707	1.332e-106	355.0	arCOG10218@1|root,320QR@2|Bacteria,1N5AN@1224|Proteobacteria,42U1Q@68525|delta/epsilon subdivisions,2WQ6Y@28221|Deltaproteobacteria,2MPQS@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Putative redox-active protein (C_GCAxxG_C_C)	-	-	-	-	-	-	-	-	-	-	-	-	C_GCAxxG_C_C
HKD2_k127_9238220_3	1121403.AUCV01000036_gene2940	3.559e-41	157.0	COG1585@1|root,COG1585@2|Bacteria,1PJH9@1224|Proteobacteria,42WNG@68525|delta/epsilon subdivisions,2WRM8@28221|Deltaproteobacteria,2MKU2@213118|Desulfobacterales	28221|Deltaproteobacteria	OU	NfeD-like C-terminal, partner-binding	-	-	-	-	-	-	-	-	-	-	-	-	NfeD
HKD2_k127_9238220_0	1121403.AUCV01000036_gene2939	1.282e-145	467.0	COG0330@1|root,COG0330@2|Bacteria,1MUM8@1224|Proteobacteria,42NX0@68525|delta/epsilon subdivisions,2WKYT@28221|Deltaproteobacteria,2MHN9@213118|Desulfobacterales	28221|Deltaproteobacteria	O	C-terminal region of band_7	-	-	-	-	-	-	-	-	-	-	-	-	Band_7,Band_7_C
HKD2_k127_9254924_12	5911.EAS02719	0.0003772	48.0	COG3914@1|root,KOG4626@2759|Eukaryota,3ZB2N@5878|Ciliophora	5878|Ciliophora	GOT	Encoded by	-	-	-	ko:K17560	-	-	-	-	ko00000,ko01009	-	-	-	TPR_1,TPR_2,TPR_8
HKD2_k127_9254924_2	1121403.AUCV01000020_gene3073	8.287e-259	813.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,42M51@68525|delta/epsilon subdivisions,2WIPP@28221|Deltaproteobacteria,2MHPE@213118|Desulfobacterales	28221|Deltaproteobacteria	NU	type II secretion system protein E	gspE	-	-	ko:K02454	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSE,T2SSE_N
HKD2_k127_9254924_4	1121403.AUCV01000008_gene1489	1.541e-155	500.0	COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,42MH9@68525|delta/epsilon subdivisions,2WJE0@28221|Deltaproteobacteria,2MIF7@213118|Desulfobacterales	28221|Deltaproteobacteria	U	General secretion pathway protein F	gspF	-	-	ko:K02455,ko:K02653	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15,3.A.15.2	-	-	T2SSF
HKD2_k127_9254924_11	589865.DaAHT2_0560	3.546e-16	79.0	COG3526@1|root,COG3526@2|Bacteria,1PSK4@1224|Proteobacteria,433FM@68525|delta/epsilon subdivisions,2WX6C@28221|Deltaproteobacteria,2MP5Z@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Rdx family	-	-	-	ko:K07401	-	-	-	-	ko00000	-	-	-	Rdx
HKD2_k127_9254924_7	1121403.AUCV01000008_gene1490	1.035e-52	190.0	COG1321@1|root,COG1321@2|Bacteria,1RHIK@1224|Proteobacteria,42SAD@68525|delta/epsilon subdivisions,2WPIC@28221|Deltaproteobacteria,2MKI7@213118|Desulfobacterales	28221|Deltaproteobacteria	K	PFAM iron dependent repressor	-	-	-	ko:K03709	-	-	-	-	ko00000,ko03000	-	-	-	Fe_dep_repr_C,Fe_dep_repress
HKD2_k127_9254924_3	1121403.AUCV01000008_gene1491	9.754e-168	545.0	COG0497@1|root,COG0497@2|Bacteria,1MUNP@1224|Proteobacteria,42N50@68525|delta/epsilon subdivisions,2WJ23@28221|Deltaproteobacteria,2MHTD@213118|Desulfobacterales	28221|Deltaproteobacteria	L	May be involved in recombinational repair of damaged DNA	recN	-	-	ko:K03631	-	-	-	-	ko00000,ko03400	-	-	-	AAA_23,SMC_N
HKD2_k127_9254924_6	1167006.UWK_02401	2.48e-110	374.0	COG0301@1|root,COG1293@1|root,COG0301@2|Bacteria,COG1293@2|Bacteria,1N1R1@1224|Proteobacteria,42MQ9@68525|delta/epsilon subdivisions,2WJPN@28221|Deltaproteobacteria,2MICH@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Thiamine biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF814,ThiI
HKD2_k127_9254924_8	211114.JOEF01000008_gene1230	4.952e-40	169.0	COG2199@1|root,COG2206@1|root,COG2206@2|Bacteria,COG3706@2|Bacteria,2GJS8@201174|Actinobacteria,4EDZE@85010|Pseudonocardiales	201174|Actinobacteria	T	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,GGDEF,HD,HD_5
HKD2_k127_9254924_0	1121403.AUCV01000012_gene4077	0.0	1267.0	COG0070@1|root,COG0493@1|root,COG1143@1|root,COG0070@2|Bacteria,COG0493@2|Bacteria,COG1143@2|Bacteria,1PBEZ@1224|Proteobacteria,42NFW@68525|delta/epsilon subdivisions,2WIQE@28221|Deltaproteobacteria,2MJ3I@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM Pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_20,Fer4_7,GXGXG,Pyr_redox_2,Pyr_redox_3,ThiF
HKD2_k127_9254924_1	1121403.AUCV01000012_gene4076	0.0	1029.0	COG0069@1|root,COG1143@1|root,COG0069@2|Bacteria,COG1143@2|Bacteria,1MU7B@1224|Proteobacteria,42MF7@68525|delta/epsilon subdivisions,2WJ17@28221|Deltaproteobacteria,2MJ5Y@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Belongs to the glutamate synthase family	-	-	1.4.1.13,1.4.1.14	ko:K00265	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4,Fer4_16,Glu_synthase
HKD2_k127_9254924_5	1121413.JMKT01000008_gene1668	2.056e-117	391.0	COG0067@1|root,COG0067@2|Bacteria,1MW6C@1224|Proteobacteria,42MTE@68525|delta/epsilon subdivisions,2WJ9E@28221|Deltaproteobacteria,2MH95@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	glutamate synthase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9254924_9	1121403.AUCV01000012_gene4074	2.445e-31	124.0	COG1826@1|root,COG1826@2|Bacteria,1Q1PB@1224|Proteobacteria,437DB@68525|delta/epsilon subdivisions,2WX7X@28221|Deltaproteobacteria	28221|Deltaproteobacteria	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system	-	-	-	ko:K03116	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
HKD2_k127_9254924_10	1121403.AUCV01000012_gene4073	3.245e-21	94.0	COG1826@1|root,COG1826@2|Bacteria,1NGDP@1224|Proteobacteria,42V5P@68525|delta/epsilon subdivisions,2WRM0@28221|Deltaproteobacteria,2MKX6@213118|Desulfobacterales	28221|Deltaproteobacteria	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system	tatA	-	-	ko:K03116	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
HKD2_k127_9277785_0	1121403.AUCV01000025_gene2284	3.075e-262	819.0	COG0442@1|root,COG0442@2|Bacteria,1MU7E@1224|Proteobacteria,42ME5@68525|delta/epsilon subdivisions,2WKA2@28221|Deltaproteobacteria,2MPSQ@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Aminoacyl-tRNA editing domain	proS	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA_edit
HKD2_k127_9277785_1	1121403.AUCV01000025_gene2285	5.269e-114	373.0	COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,42M6W@68525|delta/epsilon subdivisions,2WIZF@28221|Deltaproteobacteria,2MIKW@213118|Desulfobacterales	28221|Deltaproteobacteria	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	relA	-	2.7.6.5	ko:K00951	ko00230,map00230	-	R00429	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
HKD2_k127_9287214_1	1288494.EBAPG3_3190	3.242e-05	49.0	COG0760@1|root,COG0760@2|Bacteria,1MVB3@1224|Proteobacteria,2VHHS@28216|Betaproteobacteria,372HQ@32003|Nitrosomonadales	28216|Betaproteobacteria	O	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation	surA	-	5.2.1.8	ko:K03771	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_3,SurA_N
HKD2_k127_9287214_0	880072.Desac_0972	6.317e-201	634.0	COG0017@1|root,COG0017@2|Bacteria,1MWFV@1224|Proteobacteria,42MJX@68525|delta/epsilon subdivisions,2WJDM@28221|Deltaproteobacteria,2MRCQ@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	class II (D, K and N)	asnS	-	6.1.1.22	ko:K01893	ko00970,map00970	M00359,M00360	R03648	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
HKD2_k127_9291451_2	589865.DaAHT2_1991	1.421e-164	521.0	COG1410@1|root,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,42Q13@68525|delta/epsilon subdivisions,2WIT3@28221|Deltaproteobacteria,2MJ08@213118|Desulfobacterales	28221|Deltaproteobacteria	E	PFAM dihydropteroate synthase DHPS	-	-	2.1.1.258	ko:K15023	ko00720,ko01120,ko01200,map00720,map01120,map01200	M00377	R02289,R10243	RC00004,RC00113,RC01144,RC02871,RC02977	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
HKD2_k127_9291451_6	1121403.AUCV01000004_gene1949	1.895e-68	237.0	2ARUS@1|root,31H6C@2|Bacteria,1RFAK@1224|Proteobacteria,42SPB@68525|delta/epsilon subdivisions,2WPJK@28221|Deltaproteobacteria,2MKD1@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Type I restriction enzyme R protein N terminus (HSDR_N)	-	-	-	-	-	-	-	-	-	-	-	-	HSDR_N_2
HKD2_k127_9291451_0	1121403.AUCV01000004_gene1948	1.766e-241	751.0	COG3200@1|root,COG3200@2|Bacteria,1MUWF@1224|Proteobacteria,42MB5@68525|delta/epsilon subdivisions,2WK7V@28221|Deltaproteobacteria,2MIDN@213118|Desulfobacterales	28221|Deltaproteobacteria	E	phospho-2-dehydro-3-deoxyheptonate aldolase	aroH	-	2.5.1.54	ko:K01626	ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_2
HKD2_k127_9291451_8	1121403.AUCV01000004_gene1947	2.597e-30	129.0	COG1762@1|root,COG1762@2|Bacteria,1RD0E@1224|Proteobacteria,42SD2@68525|delta/epsilon subdivisions,2WP7H@28221|Deltaproteobacteria,2MKBM@213118|Desulfobacterales	28221|Deltaproteobacteria	GT	PFAM phosphoenolpyruvate-dependent sugar phosphotransferase system EIIA 2	ptsN	-	-	ko:K02806	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	-	-	-	PTS_EIIA_2
HKD2_k127_9291451_1	1121403.AUCV01000004_gene1946	2.008e-202	641.0	COG1508@1|root,COG1508@2|Bacteria,1MW4V@1224|Proteobacteria,42M3C@68525|delta/epsilon subdivisions,2WJ21@28221|Deltaproteobacteria,2MHTM@213118|Desulfobacterales	28221|Deltaproteobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	rpoN	-	-	ko:K03092	ko02020,ko05111,map02020,map05111	-	-	-	ko00000,ko00001,ko03021	-	-	-	Sigma54_AID,Sigma54_CBD,Sigma54_DBD
HKD2_k127_9291451_4	1121403.AUCV01000004_gene1945	2.3e-119	392.0	COG1137@1|root,COG1137@2|Bacteria,1MU8M@1224|Proteobacteria,42M4J@68525|delta/epsilon subdivisions,2WJM8@28221|Deltaproteobacteria,2MI5W@213118|Desulfobacterales	28221|Deltaproteobacteria	S	PFAM ABC transporter	lptB	-	-	ko:K06861	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	1.B.42.1	-	-	ABC_tran,BCA_ABC_TP_C
HKD2_k127_9291451_7	1121403.AUCV01000004_gene1944	5.595e-52	190.0	COG1934@1|root,COG1934@2|Bacteria,1RM28@1224|Proteobacteria,42V9N@68525|delta/epsilon subdivisions,2WRB1@28221|Deltaproteobacteria,2MM6S@213118|Desulfobacterales	28221|Deltaproteobacteria	S	OstA-like protein	lptA	-	-	ko:K09774	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	OstA
HKD2_k127_9291451_3	1121403.AUCV01000004_gene1943	9.561e-149	477.0	COG0548@1|root,COG0548@2|Bacteria,1MU17@1224|Proteobacteria,42N8G@68525|delta/epsilon subdivisions,2WKBC@28221|Deltaproteobacteria,2MI9G@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Belongs to the acetylglutamate kinase family. ArgB subfamily	argB	GO:0003674,GO:0003824,GO:0003991,GO:0005488,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0019752,GO:0031406,GO:0034618,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.2.8	ko:K00930	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R02649	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase
HKD2_k127_9291451_5	1121403.AUCV01000004_gene1942	4.283e-110	363.0	COG4992@1|root,COG4992@2|Bacteria,1MV3C@1224|Proteobacteria,42MHH@68525|delta/epsilon subdivisions,2WIMW@28221|Deltaproteobacteria,2MHRT@213118|Desulfobacterales	28221|Deltaproteobacteria	E	TIGRFAM acetylornithine and succinylornithine	argD	-	2.6.1.11,2.6.1.17	ko:K00821	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	iAF987.Gmet_0204	Aminotran_3
HKD2_k127_9317935_2	941449.dsx2_0305	1.192e-24	107.0	COG0577@1|root,COG0577@2|Bacteria,1MWBK@1224|Proteobacteria,42PZC@68525|delta/epsilon subdivisions,2WK59@28221|Deltaproteobacteria,2M9AF@213115|Desulfovibrionales	28221|Deltaproteobacteria	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HKD2_k127_9317935_1	880072.Desac_0002	1.326e-69	246.0	COG2820@1|root,COG2820@2|Bacteria,1P0EC@1224|Proteobacteria,43CGE@68525|delta/epsilon subdivisions,2WPUN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	F	Phosphorylase superfamily	-	-	2.4.2.3	ko:K00757	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01876,R02484,R08229	RC00063	ko00000,ko00001,ko01000	-	-	-	PNP_UDP_1
HKD2_k127_9317935_0	690850.Desaf_3773	6.391e-94	316.0	COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,42QF5@68525|delta/epsilon subdivisions,2WK2K@28221|Deltaproteobacteria,2M96E@213115|Desulfovibrionales	28221|Deltaproteobacteria	V	pfam abc	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD2_k127_9317935_3	1031288.AXAA01000013_gene522	5.471e-07	52.0	COG0845@1|root,COG0845@2|Bacteria,1V158@1239|Firmicutes,25CIT@186801|Clostridia,36DSX@31979|Clostridiaceae	186801|Clostridia	M	HlyD family secretion protein	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
HKD2_k127_9342479_1	521011.Mpal_2277	6.064e-133	432.0	COG0614@1|root,arCOG03611@2157|Archaea	2157|Archaea	P	PFAM PKD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CBM_6,Lipase_GDSL_2,NHL,NosD,PKD,Peptidase_C1,Peptidase_S8
HKD2_k127_9342479_3	1167006.UWK_00957	8.696e-56	211.0	COG1443@1|root,COG1443@2|Bacteria,1P8AM@1224|Proteobacteria,42T9Z@68525|delta/epsilon subdivisions,2WP8K@28221|Deltaproteobacteria,2MM8R@213118|Desulfobacterales	28221|Deltaproteobacteria	I	NUDIX domain	-	-	5.3.3.2	ko:K01823	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00095,M00096,M00364,M00365,M00366,M00367	R01123	RC00455	ko00000,ko00001,ko00002,ko01000	-	-	-	NUDIX
HKD2_k127_9342479_2	667121.ET1_03_01130	3.944e-56	209.0	COG0363@1|root,COG0363@2|Bacteria,1R5K6@1224|Proteobacteria,1S11C@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	6-phosphogluconolactonase	pgl	-	3.1.1.31	ko:K01057	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200	M00004,M00006,M00008	R02035	RC00537	ko00000,ko00001,ko00002,ko01000	-	-	-	Glucosamine_iso
HKD2_k127_9342479_0	1121403.AUCV01000025_gene2293	1.124e-226	724.0	COG0116@1|root,COG1092@1|root,COG0116@2|Bacteria,COG1092@2|Bacteria,1MUQM@1224|Proteobacteria,42NJ1@68525|delta/epsilon subdivisions,2WJ5S@28221|Deltaproteobacteria,2MIZQ@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Belongs to the methyltransferase superfamily	rlmL	-	2.1.1.173,2.1.1.264	ko:K07444,ko:K12297	-	-	R07234	RC00003	ko00000,ko01000,ko03009	-	-	-	Methyltrans_SAM,THUMP,UPF0020
HKD2_k127_9352183_3	589865.DaAHT2_0939	1.297e-61	219.0	COG0602@1|root,COG0602@2|Bacteria,1MUJ2@1224|Proteobacteria,42RT9@68525|delta/epsilon subdivisions,2WNJ0@28221|Deltaproteobacteria,2MIGR@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds	queE	-	4.3.99.3	ko:K10026	ko00790,ko01100,map00790,map01100	-	R10002	RC02989	ko00000,ko00001,ko01000,ko03016	-	-	iAF987.Gmet_1658	Fer4_14,Radical_SAM
HKD2_k127_9352183_4	1121403.AUCV01000002_gene492	1.073e-53	191.0	COG0720@1|root,COG0720@2|Bacteria,1RI4P@1224|Proteobacteria,42TJ5@68525|delta/epsilon subdivisions,2WQ2Z@28221|Deltaproteobacteria,2MK6V@213118|Desulfobacterales	28221|Deltaproteobacteria	H	PFAM 6-pyruvoyl tetrahydropterin synthase	-	-	4.1.2.50,4.2.3.12	ko:K01737	ko00790,ko01100,map00790,map01100	M00842,M00843	R04286,R09959	RC01117,RC02846,RC02847	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	PTPS
HKD2_k127_9352183_0	1167006.UWK_03233	6.797e-144	470.0	COG4198@1|root,COG4198@2|Bacteria,1NPPY@1224|Proteobacteria,42NTB@68525|delta/epsilon subdivisions,2WKNX@28221|Deltaproteobacteria,2MIZG@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF1015)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1015
HKD2_k127_9352183_2	1121403.AUCV01000002_gene493	8.566e-62	221.0	COG4123@1|root,COG4123@2|Bacteria,1MXEQ@1224|Proteobacteria,42SAA@68525|delta/epsilon subdivisions,2WPCM@28221|Deltaproteobacteria,2MJTD@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Methyltransferase small domain	-	-	2.1.1.223	ko:K15460	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	MTS,Methyltransf_31
HKD2_k127_9352183_1	1232410.KI421424_gene1701	2.753e-140	454.0	COG0606@1|root,COG0606@2|Bacteria,1MU4R@1224|Proteobacteria,42NBJ@68525|delta/epsilon subdivisions,2WJ52@28221|Deltaproteobacteria,43SC2@69541|Desulfuromonadales	28221|Deltaproteobacteria	O	PFAM magnesium chelatase ChlI subunit	comM	-	-	ko:K07391	-	-	-	-	ko00000	-	-	-	ChlI,Mg_chelatase,Mg_chelatase_C
HKD2_k127_9355741_5	1167006.UWK_00890	1.724e-89	300.0	COG0704@1|root,COG0704@2|Bacteria,1MUMI@1224|Proteobacteria,42QWG@68525|delta/epsilon subdivisions,2WN1U@28221|Deltaproteobacteria,2MICR@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Plays a role in the regulation of phosphate uptake	phoU	-	-	ko:K02039	-	-	-	-	ko00000	-	-	-	PhoU
HKD2_k127_9355741_1	1167006.UWK_00889	1.059e-177	567.0	COG0573@1|root,COG0573@2|Bacteria,1MVKP@1224|Proteobacteria,42N2N@68525|delta/epsilon subdivisions,2WJJ1@28221|Deltaproteobacteria,2MHPU@213118|Desulfobacterales	28221|Deltaproteobacteria	P	probably responsible for the translocation of the substrate across the membrane	pstC	-	-	ko:K02037	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1,DUF3708
HKD2_k127_9355741_0	1121403.AUCV01000001_gene702	2.171e-181	577.0	COG0581@1|root,COG0581@2|Bacteria,1MUWB@1224|Proteobacteria,42MWK@68525|delta/epsilon subdivisions,2WJKH@28221|Deltaproteobacteria,2MJ8E@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Domain of unknown function (DUF3333)	pstA	-	-	ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1,DUF3333
HKD2_k127_9355741_2	1167006.UWK_00886	5.582e-145	462.0	COG1117@1|root,COG1117@2|Bacteria,1MU16@1224|Proteobacteria,42MWA@68525|delta/epsilon subdivisions,2WJEX@28221|Deltaproteobacteria,2MIMW@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	pstB	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
HKD2_k127_9355741_3	1167006.UWK_02319	1.122e-130	423.0	COG0755@1|root,COG0755@2|Bacteria,1RG6M@1224|Proteobacteria,43BH8@68525|delta/epsilon subdivisions,2X6VM@28221|Deltaproteobacteria,2MPIN@213118|Desulfobacterales	28221|Deltaproteobacteria	O	TIGRFAM cytochrome c-type biogenesis protein CcsB	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C_asm
HKD2_k127_9355741_4	1121403.AUCV01000024_gene3425	2.917e-94	316.0	COG1333@1|root,COG1333@2|Bacteria,1N6XE@1224|Proteobacteria,42NBB@68525|delta/epsilon subdivisions,2WIMD@28221|Deltaproteobacteria,2MIEB@213118|Desulfobacterales	28221|Deltaproteobacteria	O	PFAM ResB family protein	-	-	-	ko:K07399	-	-	-	-	ko00000	-	-	-	ResB
HKD2_k127_9391551_1	1167006.UWK_01406	4.64e-96	319.0	COG2414@1|root,COG2414@2|Bacteria,1MWBB@1224|Proteobacteria,42NR7@68525|delta/epsilon subdivisions,2WK49@28221|Deltaproteobacteria,2MHYC@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Aldehyde ferredoxin oxidoreductase	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
HKD2_k127_9391551_6	1121405.dsmv_2347	7.923e-06	49.0	COG0515@1|root,COG0664@1|root,COG0515@2|Bacteria,COG0664@2|Bacteria,1MV1P@1224|Proteobacteria,42PPB@68525|delta/epsilon subdivisions,2WJPG@28221|Deltaproteobacteria,2MI4A@213118|Desulfobacterales	28221|Deltaproteobacteria	KLT	Protein tyrosine kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,cNMP_binding
HKD2_k127_9391551_5	525897.Dbac_2312	2.592e-14	76.0	COG3350@1|root,COG3350@2|Bacteria,1NE2T@1224|Proteobacteria,42VZQ@68525|delta/epsilon subdivisions,2WSDU@28221|Deltaproteobacteria,2MD4Y@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	YHS domain	-	-	-	-	-	-	-	-	-	-	-	-	YHS
HKD2_k127_9391551_2	589865.DaAHT2_0132	4.98e-60	218.0	2BCS0@1|root,32VCH@2|Bacteria,1NC4G@1224|Proteobacteria,43BIY@68525|delta/epsilon subdivisions,2X6XE@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9391551_0	589865.DaAHT2_1551	8.099e-201	634.0	COG0422@1|root,COG0422@2|Bacteria,1MUVV@1224|Proteobacteria,42MMB@68525|delta/epsilon subdivisions,2WJEI@28221|Deltaproteobacteria,2MIFI@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction	thiC	-	4.1.99.17	ko:K03147	ko00730,ko01100,map00730,map01100	M00127	R03472	RC03251,RC03252	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2910	ThiC_Rad_SAM
HKD2_k127_9391551_3	1121403.AUCV01000001_gene745	1.021e-36	143.0	COG0664@1|root,COG0664@2|Bacteria	2|Bacteria	T	cyclic nucleotide binding	-	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	TPR_6,cNMP_binding
HKD2_k127_9392715_8	1167006.UWK_00302	2.853e-11	67.0	COG0543@1|root,COG0543@2|Bacteria,1R6QZ@1224|Proteobacteria,42MVW@68525|delta/epsilon subdivisions,2WNRN@28221|Deltaproteobacteria,2MPYR@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B	-	-	-	-	-	-	-	-	-	-	-	-	DHODB_Fe-S_bind,FAD_binding_6,NAD_binding_1
HKD2_k127_9392715_3	1167006.UWK_00301	1.977e-119	396.0	COG0479@1|root,COG0479@2|Bacteria,1QVWG@1224|Proteobacteria,43BWA@68525|delta/epsilon subdivisions,2X771@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_22
HKD2_k127_9392715_0	589865.DaAHT2_2012	7.131e-215	679.0	COG3383@1|root,COG3383@2|Bacteria,1QTZB@1224|Proteobacteria,42SPZ@68525|delta/epsilon subdivisions,2WIV9@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Fer2_4,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
HKD2_k127_9392715_5	1167006.UWK_00299	1.881e-54	194.0	COG3383@1|root,COG3383@2|Bacteria,1NW4J@1224|Proteobacteria,42RH9@68525|delta/epsilon subdivisions,2WNSH@28221|Deltaproteobacteria,2MKPE@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Molybdopterin oxidoreductase Fe4S4 domain	-	-	-	-	-	-	-	-	-	-	-	-	Molybdop_Fe4S4,Molybdopterin
HKD2_k127_9392715_4	1121403.AUCV01000002_gene474	1.548e-61	215.0	COG4747@1|root,COG4747@2|Bacteria	2|Bacteria	-	-	hom	-	1.1.1.3,1.1.1.399,1.1.1.95,4.3.1.19	ko:K00003,ko:K00058,ko:K01754,ko:K04767	ko00260,ko00270,ko00290,ko00300,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00260,map00270,map00290,map00300,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00017,M00018,M00020,M00570	R00220,R00996,R01513,R01773,R01775	RC00031,RC00087,RC00418,RC02600	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C,ACT,CBS,Homoserine_dh,Lactamase_B,NAD_binding_3
HKD2_k127_9392715_7	706587.Desti_4440	1.173e-31	129.0	2DDIC@1|root,32U1K@2|Bacteria,1NDK2@1224|Proteobacteria,42VX8@68525|delta/epsilon subdivisions,2WSEV@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9392715_2	706587.Desti_4441	1.031e-128	422.0	COG0730@1|root,COG0730@2|Bacteria,1NJ47@1224|Proteobacteria,42P2D@68525|delta/epsilon subdivisions,2WMG7@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
HKD2_k127_9392715_6	1123376.AUIU01000019_gene1273	8.329e-54	199.0	COG0589@1|root,COG0589@2|Bacteria,3J1A7@40117|Nitrospirae	40117|Nitrospirae	T	Belongs to the universal stress protein A family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD2_k127_9392715_1	1121403.AUCV01000030_gene2784	6.619e-153	488.0	COG0730@1|root,COG0730@2|Bacteria,1Q05R@1224|Proteobacteria,42NT9@68525|delta/epsilon subdivisions,2WJVB@28221|Deltaproteobacteria,2MJPE@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Sulfite exporter TauE/SafE	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
HKD2_k127_9404263_9	1121403.AUCV01000030_gene2784	1.161e-20	96.0	COG0730@1|root,COG0730@2|Bacteria,1Q05R@1224|Proteobacteria,42NT9@68525|delta/epsilon subdivisions,2WJVB@28221|Deltaproteobacteria,2MJPE@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Sulfite exporter TauE/SafE	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
HKD2_k127_9404263_10	1121403.AUCV01000030_gene2785	2.486e-19	92.0	2EGXE@1|root,33APK@2|Bacteria,1N7CV@1224|Proteobacteria,42WGR@68525|delta/epsilon subdivisions,2WRN7@28221|Deltaproteobacteria,2MPBV@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9404263_1	880072.Desac_1217	2.77e-240	760.0	COG0466@1|root,COG0466@2|Bacteria,1R6HF@1224|Proteobacteria,42QHZ@68525|delta/epsilon subdivisions,2WJNZ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	Response regulator receiver	-	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,Lon_C,Response_reg
HKD2_k127_9404263_7	1167006.UWK_00835	8.338e-99	339.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MR8@68525|delta/epsilon subdivisions,2WIUA@28221|Deltaproteobacteria,2MPS8@213118|Desulfobacterales	28221|Deltaproteobacteria	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	2.7.13.3	ko:K02482	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
HKD2_k127_9404263_2	1123392.AQWL01000006_gene639	1.441e-183	586.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VHSB@28216|Betaproteobacteria,1KSIU@119069|Hydrogenophilales	119069|Hydrogenophilales	T	Sigma-54 interaction domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD2_k127_9404263_3	1121403.AUCV01000010_gene1400	3.486e-183	582.0	COG0745@1|root,COG2199@1|root,COG3290@1|root,COG0745@2|Bacteria,COG2199@2|Bacteria,COG3290@2|Bacteria,1NWAF@1224|Proteobacteria,43DAI@68525|delta/epsilon subdivisions	1224|Proteobacteria	T	diguanylate cyclase	-	-	3.1.4.52	ko:K13246	ko05111,map05111	-	R08991	RC00296	ko00000,ko00001,ko01000	-	-	-	EAL,GGDEF,HTH_18,HWE_HK,HisKA_2,PAS,PAS_3,PAS_9,Response_reg,SpoIIE,Trans_reg_C
HKD2_k127_9404263_5	1121403.AUCV01000010_gene1399	1.499e-141	469.0	COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,42M0Y@68525|delta/epsilon subdivisions,2WIR4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HATPase_c,HisKA,Hpt,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg
HKD2_k127_9404263_0	1121403.AUCV01000010_gene1398	8.962e-314	994.0	COG0210@1|root,COG1379@1|root,COG0210@2|Bacteria,COG1379@2|Bacteria,1MU0G@1224|Proteobacteria,42MKU@68525|delta/epsilon subdivisions,2WJR3@28221|Deltaproteobacteria,2MIS3@213118|Desulfobacterales	28221|Deltaproteobacteria	L	PFAM UvrD REP helicase	-	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
HKD2_k127_9404263_8	429009.Adeg_0190	2.093e-39	163.0	COG1057@1|root,COG1057@2|Bacteria,1V3SK@1239|Firmicutes,24JFM@186801|Clostridia,42EM4@68295|Thermoanaerobacterales	186801|Clostridia	H	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)	nadD	-	2.7.7.18	ko:K00969	ko00760,ko01100,map00760,map01100	M00115	R00137,R03005	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
HKD2_k127_9404263_4	589865.DaAHT2_1155	1.571e-181	582.0	COG0014@1|root,COG0014@2|Bacteria,1MUGJ@1224|Proteobacteria,42ME0@68525|delta/epsilon subdivisions,2WJB8@28221|Deltaproteobacteria,2MHR6@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate	proA	GO:0003674,GO:0003824,GO:0004350,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0055114	1.2.1.41	ko:K00147	ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230	M00015	R03313	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
HKD2_k127_9404263_6	1121403.AUCV01000010_gene1395	1.118e-137	445.0	COG0263@1|root,COG0263@2|Bacteria,1MUBG@1224|Proteobacteria,42NEA@68525|delta/epsilon subdivisions,2WIVS@28221|Deltaproteobacteria,2MHN5@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate	proB	GO:0003674,GO:0003824,GO:0004349,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0018130,GO:0019202,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.2.11	ko:K00931	ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230	M00015	R00239	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_3198	AA_kinase,PUA
HKD2_k127_9405299_3	243090.RB11091	7.789e-47	186.0	COG4191@1|root,COG5000@1|root,COG4191@2|Bacteria,COG5000@2|Bacteria,2J04C@203682|Planctomycetes	203682|Planctomycetes	T	sensory box sensor histidine kinase VC1084 imported	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_4,PAS_9,Response_reg
HKD2_k127_9405299_5	1313301.AUGC01000004_gene2228	1.104e-25	121.0	COG0642@1|root,COG3437@1|root,COG2205@2|Bacteria,COG3437@2|Bacteria,4NGZ0@976|Bacteroidetes	976|Bacteroidetes	T	Response regulator receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,MASE3,Response_reg
HKD2_k127_9405299_6	589865.DaAHT2_0481	3.02e-19	94.0	COG0607@1|root,COG1633@1|root,COG0607@2|Bacteria,COG1633@2|Bacteria,1MZPW@1224|Proteobacteria,42NX5@68525|delta/epsilon subdivisions,2WMJ4@28221|Deltaproteobacteria,2MJ8M@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Rubrerythrin	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese,Rubrerythrin
HKD2_k127_9405299_2	177437.HRM2_23720	8.849e-109	359.0	COG4866@1|root,COG4866@2|Bacteria,1RIUZ@1224|Proteobacteria,42P4H@68525|delta/epsilon subdivisions,2WPMI@28221|Deltaproteobacteria,2MM47@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Uncharacterised conserved protein (DUF2156)	-	-	-	ko:K01163	-	-	-	-	ko00000	-	-	-	DUF2156
HKD2_k127_9405299_0	289376.THEYE_A0244	4.44e-219	695.0	COG2855@1|root,COG2855@2|Bacteria	2|Bacteria	P	membrane	-	-	-	-	-	-	-	-	-	-	-	-	Cons_hypoth698
HKD2_k127_9405299_7	883.DvMF_2093	2.646e-11	71.0	2EQ37@1|root,33HPJ@2|Bacteria,1P4VH@1224|Proteobacteria,43392@68525|delta/epsilon subdivisions,2WYJD@28221|Deltaproteobacteria,2MDXM@213115|Desulfovibrionales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9405299_1	880073.Calab_0517	8.843e-166	530.0	COG1092@1|root,COG1092@2|Bacteria,2NPFM@2323|unclassified Bacteria	2|Bacteria	J	S-adenosylmethionine-dependent methyltransferase	rlmI	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008173,GO:0008649,GO:0008757,GO:0009383,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.173,2.1.1.191,2.1.1.264	ko:K06969,ko:K12297	-	-	R07234	RC00003	ko00000,ko01000,ko03009	-	-	-	Methyltrans_SAM
HKD2_k127_9405299_4	1158292.JPOE01000002_gene3845	2.465e-26	108.0	COG3636@1|root,COG3636@2|Bacteria,1N75D@1224|Proteobacteria,2VUBY@28216|Betaproteobacteria,1KMGR@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	addiction module antidote protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
HKD2_k127_9405905_5	1121403.AUCV01000007_gene1243	5.166e-31	126.0	COG0071@1|root,COG0071@2|Bacteria,1RE2H@1224|Proteobacteria,42RP0@68525|delta/epsilon subdivisions,2WNC4@28221|Deltaproteobacteria,2MK0Y@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
HKD2_k127_9405905_4	1121403.AUCV01000021_gene3574	2.561e-60	216.0	COG0727@1|root,COG0727@2|Bacteria,1RIJV@1224|Proteobacteria,42U8U@68525|delta/epsilon subdivisions,2WPB4@28221|Deltaproteobacteria,2MKIE@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Putative zinc- or iron-chelating domain	-	-	-	-	-	-	-	-	-	-	-	-	CxxCxxCC
HKD2_k127_9405905_2	439235.Dalk_3513	5.284e-128	437.0	COG2204@1|root,COG5000@1|root,COG5002@1|root,COG2204@2|Bacteria,COG5000@2|Bacteria,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,43CS7@68525|delta/epsilon subdivisions,2X7ZW@28221|Deltaproteobacteria,2MPMK@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_7,PAS_8,PAS_9,Response_reg,SBP_bac_3,sCache_3_2
HKD2_k127_9405905_6	1322246.BN4_11095	4.077e-19	103.0	COG0642@1|root,COG5000@1|root,COG2205@2|Bacteria,COG5000@2|Bacteria,1Q0K1@1224|Proteobacteria,43EQ6@68525|delta/epsilon subdivisions,2X9KG@28221|Deltaproteobacteria,2MERK@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c
HKD2_k127_9405905_1	1121403.AUCV01000007_gene1242	6.578e-148	475.0	COG0489@1|root,COG0489@2|Bacteria,1MU7R@1224|Proteobacteria,42NR0@68525|delta/epsilon subdivisions,2WIPG@28221|Deltaproteobacteria,2MHV5@213118|Desulfobacterales	28221|Deltaproteobacteria	D	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP	-	-	-	-	-	-	-	-	-	-	-	-	ParA
HKD2_k127_9405905_3	589865.DaAHT2_0323	5.956e-92	306.0	COG0491@1|root,COG0491@2|Bacteria,1MUDN@1224|Proteobacteria,42QWD@68525|delta/epsilon subdivisions,2WNNG@28221|Deltaproteobacteria,2MPUM@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HKD2_k127_9405905_0	1121403.AUCV01000007_gene1240	1.636e-153	491.0	COG3276@1|root,COG3276@2|Bacteria,1MWXH@1224|Proteobacteria,42M49@68525|delta/epsilon subdivisions,2WJ5G@28221|Deltaproteobacteria,2MIIX@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Elongation factor SelB winged helix	selB	-	-	ko:K03833	-	-	-	-	ko00000,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,SelB-wing_2,SelB-wing_3
HKD2_k127_9437666_9	1167006.UWK_00175	6.026e-05	50.0	COG5607@1|root,COG5607@2|Bacteria,1NGVB@1224|Proteobacteria,42X7Z@68525|delta/epsilon subdivisions,2WSMB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	CHAD domain	-	-	-	-	-	-	-	-	-	-	-	-	CHAD
HKD2_k127_9437666_1	1121403.AUCV01000003_gene1783	1.149e-171	546.0	COG1364@1|root,COG1364@2|Bacteria,1MU0T@1224|Proteobacteria,42M6S@68525|delta/epsilon subdivisions,2WJU8@28221|Deltaproteobacteria,2MIPX@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate	argJ	GO:0003674,GO:0003824,GO:0004042,GO:0004358,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006592,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.3.1.1,2.3.1.35	ko:K00620	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259,R02282	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	ArgJ
HKD2_k127_9437666_6	909663.KI867149_gene3387	4.595e-76	262.0	COG0586@1|root,COG0586@2|Bacteria,1MX4M@1224|Proteobacteria,42RCV@68525|delta/epsilon subdivisions,2WN35@28221|Deltaproteobacteria,2MR44@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	SNARE associated Golgi protein	-	-	-	ko:K03975	-	-	-	-	ko00000	-	-	-	SNARE_assoc
HKD2_k127_9437666_0	1121403.AUCV01000003_gene1782	6.086e-186	593.0	COG1502@1|root,COG1502@2|Bacteria,1MWUW@1224|Proteobacteria,42PV9@68525|delta/epsilon subdivisions,2WKF2@28221|Deltaproteobacteria,2MJW6@213118|Desulfobacterales	28221|Deltaproteobacteria	I	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol	clsA	-	-	ko:K06131	ko00564,ko01100,map00564,map01100	-	R07390	RC00017	ko00000,ko00001,ko01000	-	-	-	PLDc_2,PLDc_N
HKD2_k127_9437666_7	1121403.AUCV01000003_gene1781	1.11e-75	261.0	COG0639@1|root,COG0639@2|Bacteria,1PXN4@1224|Proteobacteria,43ABG@68525|delta/epsilon subdivisions,2WS17@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Calcineurin-like phosphoesterase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos_2
HKD2_k127_9437666_3	1167006.UWK_02665	2.875e-128	421.0	COG2326@1|root,COG2326@2|Bacteria,1MVE2@1224|Proteobacteria,42M26@68525|delta/epsilon subdivisions,2WN8V@28221|Deltaproteobacteria	68525|delta/epsilon subdivisions	S	TIGRFAM polyphosphate kinase 2, PA0141 family	-	-	2.7.4.1	ko:K22468	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PPK2
HKD2_k127_9437666_2	1121403.AUCV01000003_gene1779	4.928e-135	436.0	COG2326@1|root,COG2326@2|Bacteria,1MVE2@1224|Proteobacteria,42M26@68525|delta/epsilon subdivisions,2WN8V@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	TIGRFAM polyphosphate kinase 2, PA0141 family	-	-	2.7.4.1	ko:K22468	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PPK2
HKD2_k127_9437666_8	765420.OSCT_0769	1.498e-37	157.0	COG5295@1|root,COG5295@2|Bacteria,2GB82@200795|Chloroflexi,377IZ@32061|Chloroflexia	32061|Chloroflexia	UW	Hep Hag repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	Pectinesterase
HKD2_k127_9437666_5	1121403.AUCV01000034_gene3835	1.228e-103	346.0	COG2378@1|root,COG2378@2|Bacteria,1P2ZE@1224|Proteobacteria,42QIS@68525|delta/epsilon subdivisions,2WMK0@28221|Deltaproteobacteria,2MKS9@213118|Desulfobacterales	28221|Deltaproteobacteria	K	WYL domain	-	-	-	ko:K13573	-	-	-	-	ko00000,ko03051	-	-	-	HTH_11,WYL
HKD2_k127_9437666_4	1121403.AUCV01000034_gene3836	5.762e-122	400.0	COG1207@1|root,COG1207@2|Bacteria,1MUPH@1224|Proteobacteria,42N3K@68525|delta/epsilon subdivisions,2WIMV@28221|Deltaproteobacteria,2MK32@213118|Desulfobacterales	28221|Deltaproteobacteria	M	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	glmU	-	2.3.1.157,2.7.7.23	ko:K04042,ko:K11528	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transf_3,NTP_transferase
HKD2_k127_9437666_10	1150469.RSPPHO_02782	0.0001689	46.0	COG3420@1|root,COG3420@2|Bacteria	2|Bacteria	P	alginic acid biosynthetic process	-	-	-	ko:K10297	-	-	-	-	ko00000,ko04121	-	-	-	Beta_helix,SLH,TIR_2
HKD2_k127_9440990_4	288000.BBta_4342	4.257e-91	315.0	COG0457@1|root,COG0457@2|Bacteria,1MVMG@1224|Proteobacteria,2TSGE@28211|Alphaproteobacteria,3JTGV@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_3,TPR_1,TPR_11,TPR_16,TPR_19,TPR_2,TPR_8
HKD2_k127_9440990_7	1167006.UWK_01407	4.763e-39	146.0	COG0235@1|root,COG0235@2|Bacteria,1N84G@1224|Proteobacteria,42RVW@68525|delta/epsilon subdivisions,2WSI5@28221|Deltaproteobacteria,2MMXM@213118|Desulfobacterales	28221|Deltaproteobacteria	G	Class II Aldolase and Adducin N-terminal domain	-	-	4.1.2.17	ko:K01628	ko00051,ko01120,map00051,map01120	-	R02262	RC00603,RC00604	ko00000,ko00001,ko01000	-	-	-	Aldolase_II
HKD2_k127_9440990_6	1121403.AUCV01000004_gene2058	1.005e-54	206.0	COG1738@1|root,COG2202@1|root,COG1738@2|Bacteria,COG2202@2|Bacteria,1NWNJ@1224|Proteobacteria	1224|Proteobacteria	T	PAS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CHASE,DUF3365,GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg,dCache_1
HKD2_k127_9440990_2	1121403.AUCV01000050_gene2112	1.059e-115	377.0	COG0479@1|root,COG0479@2|Bacteria,1MVHS@1224|Proteobacteria,42M2J@68525|delta/epsilon subdivisions,2WK9D@28221|Deltaproteobacteria,2MIY2@213118|Desulfobacterales	28221|Deltaproteobacteria	C	TIGRFAM succinate dehydrogenase and fumarate reductase iron-sulfur protein	frdB	-	1.3.5.1,1.3.5.4	ko:K00240,ko:K00245	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020	M00009,M00011,M00149,M00150,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2395	Fer2_3,Fer4_7,Fer4_8
HKD2_k127_9440990_8	1173025.GEI7407_3006	1.457e-35	145.0	COG4328@1|root,COG4328@2|Bacteria,1G1FQ@1117|Cyanobacteria,1H821@1150|Oscillatoriales	1117|Cyanobacteria	S	Protein of unknown function (DUF429)	-	-	-	-	-	-	-	-	-	-	-	-	DUF429
HKD2_k127_9440990_0	1121403.AUCV01000050_gene2113	5e-324	1000.0	COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,42M81@68525|delta/epsilon subdivisions,2WIJ5@28221|Deltaproteobacteria,2MHSR@213118|Desulfobacterales	28221|Deltaproteobacteria	C	TIGRFAM succinate dehydrogenase or fumarate reductase, flavoprotein subunit	frdA	-	1.3.5.1,1.3.5.4	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
HKD2_k127_9440990_5	1121403.AUCV01000050_gene2114	9.217e-65	229.0	2CAZH@1|root,2Z7RU@2|Bacteria,1RBDC@1224|Proteobacteria,42SC7@68525|delta/epsilon subdivisions,2WP8S@28221|Deltaproteobacteria,2MJFJ@213118|Desulfobacterales	28221|Deltaproteobacteria	C	TIGRFAM succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family	frdC	-	-	ko:K00241	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	Sdh_cyt
HKD2_k127_9440990_3	880072.Desac_1865	7.284e-101	353.0	COG1313@1|root,COG1313@2|Bacteria,1NZAK@1224|Proteobacteria,42NYF@68525|delta/epsilon subdivisions,2WIT2@28221|Deltaproteobacteria,2MQSH@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	PFAM Radical SAM	-	-	1.97.1.4	ko:K04070	-	-	-	-	ko00000,ko01000	-	-	-	Radical_SAM
HKD2_k127_9440990_1	338966.Ppro_1707	9.032e-163	521.0	COG0709@1|root,COG0709@2|Bacteria,1MWFG@1224|Proteobacteria,42MC3@68525|delta/epsilon subdivisions,2WK3M@28221|Deltaproteobacteria,43UBE@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	AIR synthase related protein, C-terminal domain	selD	-	2.7.9.3	ko:K01008	ko00450,ko01100,map00450,map01100	-	R03595	RC00002,RC02878	ko00000,ko00001,ko01000,ko03016	-	-	-	AIRS,AIRS_C
HKD2_k127_9440990_9	589865.DaAHT2_0136	7.932e-24	105.0	COG0425@1|root,COG0425@2|Bacteria,1N08X@1224|Proteobacteria,42RUG@68525|delta/epsilon subdivisions,2WNNK@28221|Deltaproteobacteria,2MJVC@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Belongs to the sulfur carrier protein TusA family	yedF	-	-	-	-	-	-	-	-	-	-	-	DrsE,TusA
HKD2_k127_9449190_1	1121403.AUCV01000019_gene3277	9.874e-196	627.0	COG3008@1|root,COG3008@2|Bacteria,1MU1T@1224|Proteobacteria,42PHS@68525|delta/epsilon subdivisions,2X5NU@28221|Deltaproteobacteria,2MMH1@213118|Desulfobacterales	28221|Deltaproteobacteria	Q	MlaD protein	-	-	-	-	-	-	-	-	-	-	-	-	MlaD
HKD2_k127_9449190_4	1121403.AUCV01000019_gene3276	2.763e-105	359.0	COG2995@1|root,COG2995@2|Bacteria,1MWG1@1224|Proteobacteria,42R11@68525|delta/epsilon subdivisions,2WMWN@28221|Deltaproteobacteria,2MMZB@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Paraquat-inducible protein A	-	-	-	ko:K03808	-	-	-	-	ko00000	-	-	-	PqiA
HKD2_k127_9449190_3	443143.GM18_2447	2.554e-130	441.0	COG1269@1|root,COG1269@2|Bacteria,1QGFB@1224|Proteobacteria,42UWC@68525|delta/epsilon subdivisions,2X5C3@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM V-type ATPase 116 kDa	-	-	-	ko:K02123	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	-
HKD2_k127_9449190_6	443143.GM18_2448	8.727e-23	99.0	COG0636@1|root,COG0636@2|Bacteria,1N5D3@1224|Proteobacteria,438SF@68525|delta/epsilon subdivisions,2WY87@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM H transporting two-sector ATPase C subunit	-	-	-	ko:K02124	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_C
HKD2_k127_9449190_7	443143.GM18_2449	1.609e-20	98.0	COG1390@1|root,COG1390@2|Bacteria	2|Bacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpE	-	-	ko:K02121	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	vATP-synt_E
HKD2_k127_9449190_9	443143.GM18_2451	3.112e-11	75.0	COG1436@1|root,COG1436@2|Bacteria	2|Bacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpF	-	-	ko:K02122	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_F
HKD2_k127_9449190_0	443143.GM18_2452	3.038e-220	697.0	COG1155@1|root,COG1155@2|Bacteria,1MWRR@1224|Proteobacteria,42NKK@68525|delta/epsilon subdivisions,2WIQQ@28221|Deltaproteobacteria,43UIJ@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	ATPsynthase alpha/beta subunit N-term extension	-	-	3.6.3.14,3.6.3.15	ko:K02117	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002,ko01000	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn
HKD2_k127_9449190_2	529709.PYCH_15750	3.045e-144	470.0	COG1156@1|root,arCOG00865@2157|Archaea,2XSYQ@28890|Euryarchaeota,2433N@183968|Thermococci	183968|Thermococci	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit	atpB	-	-	ko:K02118	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N
HKD2_k127_9449190_8	443143.GM18_2454	1.496e-15	78.0	COG1394@1|root,COG1394@2|Bacteria,1PA1A@1224|Proteobacteria,42VQ3@68525|delta/epsilon subdivisions,2WT1Q@28221|Deltaproteobacteria,43VWT@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	ATP synthase subunit D	-	-	-	ko:K02120	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_D
HKD2_k127_9499839_14	593750.Metfor_2191	1.023e-08	68.0	COG0784@1|root,arCOG02348@1|root,arCOG02367@1|root,arCOG04001@1|root,arCOG02348@2157|Archaea,arCOG02367@2157|Archaea,arCOG02386@2157|Archaea,arCOG04001@2157|Archaea	2157|Archaea	T	tigrfam pas	-	-	-	-	-	-	-	-	-	-	-	-	BAT,GAF_2,HATPase_c,HTH_10,HisKA,HisKA_2,MCPsignal,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg
HKD2_k127_9499839_5	760117.JN27_14130	1.817e-129	426.0	COG0683@1|root,COG0683@2|Bacteria,1MX94@1224|Proteobacteria,2VPP2@28216|Betaproteobacteria,478IT@75682|Oxalobacteraceae	28216|Betaproteobacteria	E	Receptor family ligand binding region	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
HKD2_k127_9499839_9	589865.DaAHT2_1361	1.505e-96	325.0	COG3221@1|root,COG3221@2|Bacteria,1NPBT@1224|Proteobacteria,42R8P@68525|delta/epsilon subdivisions	1224|Proteobacteria	P	TIGRFAM phosphonate ABC transporter, periplasmic phosphonate-binding protein	-	-	-	ko:K02044	ko02010,map02010	M00223	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.9	-	-	Phosphonate-bd
HKD2_k127_9499839_13	589865.DaAHT2_1362	1.7e-37	163.0	COG4251@1|root,COG4251@2|Bacteria,1NSQ1@1224|Proteobacteria,42RAK@68525|delta/epsilon subdivisions,2WJRA@28221|Deltaproteobacteria,2MKMD@213118|Desulfobacterales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF3365,HATPase_c,HisKA
HKD2_k127_9499839_2	1167006.UWK_00197	2.967e-169	559.0	COG0834@1|root,COG2204@1|root,COG5002@1|root,COG0834@2|Bacteria,COG2204@2|Bacteria,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,43CS7@68525|delta/epsilon subdivisions,2X7ZW@28221|Deltaproteobacteria,2MPMK@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_7,PAS_8,PAS_9,Response_reg,SBP_bac_3,sCache_3_2
HKD2_k127_9499839_12	1283300.ATXB01000001_gene1197	2.325e-52	193.0	COG2340@1|root,COG2340@2|Bacteria,1RI4E@1224|Proteobacteria,1SAPW@1236|Gammaproteobacteria,1XGH1@135618|Methylococcales	135618|Methylococcales	S	SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains.	-	-	-	-	-	-	-	-	-	-	-	-	CAP
HKD2_k127_9499839_0	335543.Sfum_3874	1.829e-201	644.0	COG0492@1|root,COG0526@1|root,COG0492@2|Bacteria,COG0526@2|Bacteria,1MV15@1224|Proteobacteria,42MHR@68525|delta/epsilon subdivisions,2WIY8@28221|Deltaproteobacteria,2MQBZ@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,cNMP_binding
HKD2_k127_9499839_10	439235.Dalk_1254	4.096e-83	287.0	COG0697@1|root,COG0697@2|Bacteria,1N024@1224|Proteobacteria,42NW9@68525|delta/epsilon subdivisions,2WJEJ@28221|Deltaproteobacteria,2MJ3K@213118|Desulfobacterales	28221|Deltaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HKD2_k127_9499839_7	1499967.BAYZ01000028_gene1309	8.483e-102	350.0	COG0410@1|root,COG0410@2|Bacteria,2NNXF@2323|unclassified Bacteria	2|Bacteria	E	ABC transporter	livF	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
HKD2_k127_9499839_8	1499967.BAYZ01000028_gene1308	3.051e-98	346.0	COG0411@1|root,COG0411@2|Bacteria,2NNYG@2323|unclassified Bacteria	2|Bacteria	E	Branched-chain amino acid ATP-binding cassette transporter	livG	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
HKD2_k127_9499839_3	1499967.BAYZ01000028_gene1307	1.326e-167	538.0	COG4177@1|root,COG4177@2|Bacteria,2NPMP@2323|unclassified Bacteria	2|Bacteria	U	Branched-chain amino acid transport system / permease component	livM	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HKD2_k127_9499839_4	1499967.BAYZ01000028_gene1306	2.542e-142	458.0	COG0559@1|root,COG0559@2|Bacteria,2NP7Z@2323|unclassified Bacteria	2|Bacteria	E	Branched-chain amino acid transport system / permease component	livH	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HKD2_k127_9499839_1	439235.Dalk_3669	3.478e-193	609.0	COG0683@1|root,COG0683@2|Bacteria,1MWJ1@1224|Proteobacteria,42MSJ@68525|delta/epsilon subdivisions,2WKHJ@28221|Deltaproteobacteria,2MITB@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Receptor family ligand binding region	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
HKD2_k127_9499839_11	1294142.CINTURNW_1218	1.031e-73	261.0	COG1013@1|root,COG1013@2|Bacteria,1TQJ2@1239|Firmicutes,25CAJ@186801|Clostridia,36WSB@31979|Clostridiaceae	186801|Clostridia	C	PFAM thiamine pyrophosphate protein domain protein TPP-binding	korB	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFO_beta_C,TPP_enzyme_C
HKD2_k127_9499839_6	1121406.JAEX01000002_gene1138	4.861e-124	417.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,1NBSJ@1224|Proteobacteria,42MXV@68525|delta/epsilon subdivisions,2WIIT@28221|Deltaproteobacteria,2M8B3@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	PFAM Pyruvate flavodoxin ferredoxin oxidoreductase	porA	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR,POR_N,Transketolase_C
HKD2_k127_9504671_1	1167006.UWK_03496	2.612e-112	365.0	COG2255@1|root,COG2255@2|Bacteria,1MU38@1224|Proteobacteria,42M99@68525|delta/epsilon subdivisions,2WJ2Q@28221|Deltaproteobacteria,2MHYU@213118|Desulfobacterales	28221|Deltaproteobacteria	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing	ruvB	-	3.6.4.12	ko:K03551	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvB_C,RuvB_N
HKD2_k127_9504671_2	177439.DP2907	1.472e-103	347.0	COG0413@1|root,COG0413@2|Bacteria,1MU3B@1224|Proteobacteria,42MES@68525|delta/epsilon subdivisions,2WIQK@28221|Deltaproteobacteria,2MIUS@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate	panB	-	2.1.2.11	ko:K00606	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R01226	RC00022,RC00200	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_transf
HKD2_k127_9504671_0	589865.DaAHT2_1201	1.586e-116	383.0	COG1951@1|root,COG1951@2|Bacteria,1MUV9@1224|Proteobacteria,42MC7@68525|delta/epsilon subdivisions,2WKIV@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	hydro-lyase, Fe-S type, tartrate fumarate subfamily, alpha subunit	fumA	-	4.2.1.2	ko:K01677	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumerase
HKD2_k127_9504671_3	589865.DaAHT2_1200	8.423e-75	255.0	COG1838@1|root,COG1838@2|Bacteria,1RCSV@1224|Proteobacteria,42NRW@68525|delta/epsilon subdivisions,2X5RX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Hydro-lyase, Fe-S type, tartrate fumarate subfamily, beta subunit	-	-	4.2.1.2	ko:K01678	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumerase_C
HKD2_k127_9504671_4	243231.GSU2528	2.133e-16	84.0	COG3712@1|root,COG3712@2|Bacteria,1N941@1224|Proteobacteria	1224|Proteobacteria	PT	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins	-	-	-	-	-	-	-	-	-	-	-	-	FecR
HKD2_k127_9579775_0	926569.ANT_24960	0.0	1059.0	COG1472@1|root,COG1472@2|Bacteria,2G5S5@200795|Chloroflexi	200795|Chloroflexi	G	Fibronectin type III-like domain	-	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C
HKD2_k127_9597698_0	1266909.AUAG01000063_gene1806	1.407e-34	149.0	COG3547@1|root,COG3547@2|Bacteria,1NGR7@1224|Proteobacteria,1RMF9@1236|Gammaproteobacteria,1WZPM@135613|Chromatiales	135613|Chromatiales	L	Transposase IS116/IS110/IS902 family	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
HKD2_k127_9624424_7	313606.M23134_05365	8.023e-27	118.0	COG3227@1|root,COG3291@1|root,COG3975@1|root,COG4733@1|root,COG3227@2|Bacteria,COG3291@2|Bacteria,COG3975@2|Bacteria,COG4733@2|Bacteria,4PKQC@976|Bacteroidetes,47SGA@768503|Cytophagia	976|Bacteroidetes	E	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	-	-	-	-	-	-	-	-	-	-	-	-	PKD,Peptidase_M9,Peptidase_M9_N
HKD2_k127_9624424_4	1121403.AUCV01000016_gene4396	1.664e-86	293.0	COG2197@1|root,COG2197@2|Bacteria,1MWGM@1224|Proteobacteria,42R03@68525|delta/epsilon subdivisions,2WMTZ@28221|Deltaproteobacteria,2MJ7X@213118|Desulfobacterales	28221|Deltaproteobacteria	T	PFAM response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HKD2_k127_9624424_2	1121403.AUCV01000016_gene4397	7.072e-158	518.0	COG3290@1|root,COG4585@1|root,COG3290@2|Bacteria,COG4585@2|Bacteria,1MWPN@1224|Proteobacteria,42RUN@68525|delta/epsilon subdivisions,2WNJZ@28221|Deltaproteobacteria,2MPS9@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE4,HAMP,HATPase_c,HisKA_3,PAS_3,PAS_4,PAS_9
HKD2_k127_9624424_6	642227.HA49_09340	1.189e-31	138.0	COG0350@1|root,COG0350@2|Bacteria,1N2YQ@1224|Proteobacteria,1S68H@1236|Gammaproteobacteria,4BV36@82986|Tatumella	1236|Gammaproteobacteria	L	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated	ogt	-	2.1.1.63	ko:K00567	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_binding_1,Methyltransf_1N
HKD2_k127_9624424_0	1121403.AUCV01000012_gene4081	3.117e-215	685.0	COG0744@1|root,COG0744@2|Bacteria,1QTST@1224|Proteobacteria,43BJ8@68525|delta/epsilon subdivisions,2X708@28221|Deltaproteobacteria,2MPMW@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Transglycosylase	-	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase
HKD2_k127_9624424_1	1121403.AUCV01000012_gene4082	1.135e-180	584.0	COG0323@1|root,COG0323@2|Bacteria,1MV61@1224|Proteobacteria,42MFX@68525|delta/epsilon subdivisions,2WJ91@28221|Deltaproteobacteria,2MIXG@213118|Desulfobacterales	28221|Deltaproteobacteria	L	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex	mutL	GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391	-	ko:K03572	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	DNA_mis_repair,HATPase_c_3,MutL_C
HKD2_k127_9624424_3	1121403.AUCV01000001_gene896	1.009e-124	413.0	COG1453@1|root,COG1453@2|Bacteria	2|Bacteria	S	Aldo/keto reductase family	-	-	-	ko:K07079	-	-	-	-	ko00000	-	-	-	Aldo_ket_red,Fer4_17
HKD2_k127_9624424_8	1033802.SSPSH_000514	1.803e-08	64.0	COG0790@1|root,COG0790@2|Bacteria,1MWPA@1224|Proteobacteria,1RPI3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	COG0790 FOG TPR repeat, SEL1 subfamily	-	-	-	ko:K07126	-	-	-	-	ko00000	-	-	-	SH3_3,Sel1
HKD2_k127_9624424_9	351016.RAZWK3B_13899	6.219e-05	55.0	COG5652@1|root,COG5652@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	VanZ
HKD2_k127_9624424_5	404589.Anae109_1579	2.155e-82	280.0	COG0705@1|root,COG0705@2|Bacteria,1MYFP@1224|Proteobacteria,42P0V@68525|delta/epsilon subdivisions,2WJGR@28221|Deltaproteobacteria,2YVSU@29|Myxococcales	28221|Deltaproteobacteria	S	Rhomboid family	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
HKD2_k127_9629768_1	1167006.UWK_01727	9.25e-165	529.0	COG0845@1|root,COG0845@2|Bacteria,1MUI8@1224|Proteobacteria,42MCZ@68525|delta/epsilon subdivisions,2WKBE@28221|Deltaproteobacteria,2MQ0M@213118|Desulfobacterales	28221|Deltaproteobacteria	M	TIGRFAM type I secretion membrane fusion protein, HlyD family	-	-	-	ko:K12542	-	M00330	-	-	ko00000,ko00002,ko02000,ko02044	3.A.1.109.4,8.A.1	-	-	HlyD_3
HKD2_k127_9629768_0	754477.Q7C_704	1.37e-235	750.0	COG2274@1|root,COG2274@2|Bacteria,1R2T0@1224|Proteobacteria,1SBE1@1236|Gammaproteobacteria,45ZQX@72273|Thiotrichales	72273|Thiotrichales	V	ABC transporter transmembrane region	-	-	-	ko:K12541	ko02010,map02010	M00330	-	-	ko00000,ko00001,ko00002,ko02000,ko02044	3.A.1.109.3,3.A.1.109.4	-	-	ABC_membrane,ABC_tran,Peptidase_C39
HKD2_k127_9629768_2	443143.GM18_1078	2.115e-53	190.0	COG5001@1|root,COG5001@2|Bacteria,1QV5H@1224|Proteobacteria,42PV8@68525|delta/epsilon subdivisions	1224|Proteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,HAMP,LapD_MoxY_N
HKD2_k127_9708707_1	933262.AXAM01000002_gene572	1.565e-13	72.0	COG0845@1|root,COG0845@2|Bacteria,1MU78@1224|Proteobacteria,42NHV@68525|delta/epsilon subdivisions,2WJBA@28221|Deltaproteobacteria,2MHST@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	acrA	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	Biotin_lipoyl_2,HlyD,HlyD_3,HlyD_D23
HKD2_k127_9708707_0	56780.SYN_02074	0.0	1226.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJVV@28221|Deltaproteobacteria,2MQ80@213462|Syntrophobacterales	28221|Deltaproteobacteria	V	TIGRFAM The (Largely Gram-negative Bacterial) Hydrophobe Amphiphile Efflux-1 (HAE1) Family	acrB	-	-	ko:K03296,ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
HKD2_k127_9709402_2	945713.IALB_0843	3.126e-12	79.0	COG4409@1|root,COG4409@2|Bacteria	2|Bacteria	G	exo-alpha-(2->6)-sialidase activity	-	-	-	-	-	-	-	-	-	-	-	-	CelD_N,Glyco_hydro_9,Laminin_G_3
HKD2_k127_9709402_0	292564.Cyagr_1908	1.591e-143	464.0	COG1064@1|root,COG1064@2|Bacteria,1G327@1117|Cyanobacteria	1117|Cyanobacteria	S	Zinc-binding alcohol dehydrogenase family protein	-	-	1.1.1.1	ko:K13953	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
HKD2_k127_9709402_1	1121403.AUCV01000007_gene1240	2.677e-101	338.0	COG3276@1|root,COG3276@2|Bacteria,1MWXH@1224|Proteobacteria,42M49@68525|delta/epsilon subdivisions,2WJ5G@28221|Deltaproteobacteria,2MIIX@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Elongation factor SelB winged helix	selB	-	-	ko:K03833	-	-	-	-	ko00000,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,SelB-wing_2,SelB-wing_3
HKD2_k127_9798879_0	443143.GM18_0613	1.748e-77	284.0	COG3656@1|root,COG3656@2|Bacteria	2|Bacteria	N	Periplasmic Protein	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,DUF2271,FGE-sulfatase,Kelch_3,TIG
HKD2_k127_9798879_2	1121897.AUGO01000003_gene2065	2.07e-26	126.0	COG1345@1|root,COG3210@1|root,COG3291@1|root,COG3656@1|root,COG1345@2|Bacteria,COG3210@2|Bacteria,COG3291@2|Bacteria,COG3656@2|Bacteria,4NFVP@976|Bacteroidetes,1HY1K@117743|Flavobacteriia,2NSFX@237|Flavobacterium	976|Bacteroidetes	N	PFAM SMP-30 Gluconolaconase	-	-	-	-	-	-	-	-	-	-	-	-	fn3
HKD2_k127_9798879_4	243231.GSU2902	4.543e-09	65.0	COG0457@1|root,COG0457@2|Bacteria	243231.GSU2902|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9798879_3	316067.Geob_3350	4.41e-20	94.0	COG2391@1|root,COG2391@2|Bacteria,1NCH7@1224|Proteobacteria,42NKG@68525|delta/epsilon subdivisions,2WJFC@28221|Deltaproteobacteria,43TGF@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Sulphur transport	-	-	-	ko:K07112	-	-	-	-	ko00000	-	-	-	Sulf_transp
HKD2_k127_9873807_4	497964.CfE428DRAFT_3540	2.116e-09	66.0	COG0484@1|root,COG0484@2|Bacteria,46S6P@74201|Verrucomicrobia	74201|Verrucomicrobia	O	DnaJ molecular chaperone homology domain	cbpA	-	-	ko:K05516	-	-	-	-	ko00000,ko03036,ko03110	-	-	-	DnaJ,DnaJ_C
HKD2_k127_9873807_1	335543.Sfum_3322	3.141e-37	158.0	COG0457@1|root,COG0457@2|Bacteria,1NJFX@1224|Proteobacteria,42ZX8@68525|delta/epsilon subdivisions,2WVHJ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9873807_0	335543.Sfum_3321	8.38e-172	568.0	COG0489@1|root,COG3206@1|root,COG0489@2|Bacteria,COG3206@2|Bacteria,1MVI9@1224|Proteobacteria,42NB4@68525|delta/epsilon subdivisions,2WK9E@28221|Deltaproteobacteria,2MRHP@213462|Syntrophobacterales	28221|Deltaproteobacteria	D	G-rich domain on putative tyrosine kinase	wzc2	-	-	ko:K16554	ko05111,map05111	-	-	-	ko00000,ko00001,ko02000	8.A.3.1	-	-	AAA_31,CbiA,GNVR,ParA,Wzz
HKD2_k127_9873807_2	929712.KI912613_gene2552	5.317e-34	146.0	COG4464@1|root,COG4464@2|Bacteria,2H0WF@201174|Actinobacteria,4CSZY@84995|Rubrobacteria	84995|Rubrobacteria	GM	protein tyrosine phosphatase activity	-	-	3.1.3.48	ko:K01104	-	-	-	-	ko00000,ko01000	-	-	-	-
HKD2_k127_9873807_3	525897.Dbac_1691	1.353e-28	124.0	COG3307@1|root,COG3307@2|Bacteria,1N225@1224|Proteobacteria,42QDQ@68525|delta/epsilon subdivisions,2WM6B@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	PFAM O-Antigen	-	-	-	ko:K18814	-	-	-	-	ko00000,ko02000	9.B.67.1	-	-	TPR_14,TPR_16,TPR_8,Wzy_C
HKD2_k127_9893785_2	1167006.UWK_01420	3.449e-149	480.0	COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,42M4Z@68525|delta/epsilon subdivisions,2WJZ3@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	-	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
HKD2_k127_9893785_4	1121403.AUCV01000001_gene898	1.325e-112	381.0	COG1295@1|root,COG1295@2|Bacteria,1QICW@1224|Proteobacteria,42MBW@68525|delta/epsilon subdivisions,2WK2Z@28221|Deltaproteobacteria,2MIKX@213118|Desulfobacterales	28221|Deltaproteobacteria	K	ribonuclease BN	-	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Rrf2,Virul_fac_BrkB
HKD2_k127_9893785_3	1121403.AUCV01000001_gene902	5.815e-137	452.0	COG0741@1|root,COG0741@2|Bacteria,1MWKE@1224|Proteobacteria,42QM3@68525|delta/epsilon subdivisions,2WKI2@28221|Deltaproteobacteria,2MI4S@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Lysin motif	-	-	-	ko:K08307	-	-	-	-	ko00000,ko01000,ko01011	-	-	-	LysM,SLT
HKD2_k127_9893785_5	340.xcc-b100_2018	8.582e-73	248.0	COG1051@1|root,COG1051@2|Bacteria,1NGJE@1224|Proteobacteria,1T1MC@1236|Gammaproteobacteria,1XD4K@135614|Xanthomonadales	135614|Xanthomonadales	F	NUDIX domain	-	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX
HKD2_k127_9893785_0	1121403.AUCV01000001_gene906	2.179e-249	780.0	COG1418@1|root,COG1418@2|Bacteria,1P7YA@1224|Proteobacteria,42KZ8@68525|delta/epsilon subdivisions,2WJG1@28221|Deltaproteobacteria,2MHS7@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Endoribonuclease that initiates mRNA decay	rny	-	-	ko:K18682	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DUF3552,HD,KH_1
HKD2_k127_9893785_1	589865.DaAHT2_0912	1.621e-187	595.0	COG0162@1|root,COG0162@2|Bacteria,1MVUQ@1224|Proteobacteria,42N2A@68525|delta/epsilon subdivisions,2WIP6@28221|Deltaproteobacteria,2MI9Q@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	GO:0003674,GO:0003824,GO:0004812,GO:0004831,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016875,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	S4,tRNA-synt_1b
HKD2_k127_9972937_3	1123376.AUIU01000015_gene472	1.221e-45	168.0	arCOG10385@1|root,32SEM@2|Bacteria	2|Bacteria	-	-	dsrJ	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9972937_1	1121403.AUCV01000004_gene2024	4.133e-123	400.0	COG0437@1|root,COG0437@2|Bacteria,1NBU3@1224|Proteobacteria,42MNU@68525|delta/epsilon subdivisions,2WJRG@28221|Deltaproteobacteria,2MIME@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein	dsrO	-	-	ko:K00184	-	-	-	-	ko00000	5.A.3	-	-	Fer4_11,Fer4_4
HKD2_k127_9972937_0	1121403.AUCV01000004_gene2025	4.26e-205	644.0	COG5557@1|root,COG5557@2|Bacteria,1PFX4@1224|Proteobacteria,42NUN@68525|delta/epsilon subdivisions,2WJHN@28221|Deltaproteobacteria,2MHX4@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM Polysulphide reductase, NrfD	dsrP	-	-	ko:K00185	-	-	-	-	ko00000	5.A.3	-	-	NrfD
HKD2_k127_9972937_2	1167006.UWK_00237	1.495e-73	258.0	COG0655@1|root,COG0655@2|Bacteria,1R13F@1224|Proteobacteria,43D5P@68525|delta/epsilon subdivisions,2X8CE@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	NAD(P)H dehydrogenase (quinone) activity	-	-	-	-	-	-	-	-	-	-	-	-	-
## 2969 queries scanned
## Total time (seconds): 106.01800727844238
## Rate: 28.00 q/s