## Sat Nov 16 16:04:11 2024
## emapper-2.1.12
## /data/home/zkh/miniconda3/envs/eggnog-mapper/bin/emapper.py -i /data/home/zkh/binning/bin_4635/bin/bin8/HKD_2_bin.49.fa -m mmseqs --itype genome -o HKD_2_bin.49 --output_dir /data/home/zkh/meta_analysis/eggnog-mapper/4635/HKD_2_bin.49 --cpu 28
##
#query	seed_ortholog	evalue	score	eggNOG_OGs	max_annot_lvl	COG_category	Description	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	PFAMs
HKD2_k127_10118740_5	370438.PTH_2214	1.407e-103	353.0	COG0469@1|root,COG0469@2|Bacteria,1TPGG@1239|Firmicutes,2489V@186801|Clostridia,260WY@186807|Peptococcaceae	186801|Clostridia	G	Belongs to the pyruvate kinase family	pyk	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PEP-utilizers,PK,PK_C
HKD2_k127_10118740_1	742818.HMPREF9451_00114	1.791e-204	643.0	COG0148@1|root,COG0148@2|Bacteria,2GJAY@201174|Actinobacteria,4CU81@84998|Coriobacteriia	84998|Coriobacteriia	H	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
HKD2_k127_10118740_7	264732.Moth_0084	4.384e-83	305.0	COG1694@1|root,COG3956@2|Bacteria,1TPK1@1239|Firmicutes,247XM@186801|Clostridia,42FE4@68295|Thermoanaerobacterales	186801|Clostridia	S	TIGRFAM MazG family protein	mazG	-	3.6.1.66	ko:K02428,ko:K02499	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000,ko03036	-	-	-	MazG,TP_methylase
HKD2_k127_10118740_13	641107.CDLVIII_0328	1.864e-33	142.0	COG0760@1|root,COG0760@2|Bacteria,1V4R1@1239|Firmicutes,25C35@186801|Clostridia,36WNP@31979|Clostridiaceae	186801|Clostridia	M	peptidyl-prolyl isomerase	prsA	-	5.2.1.8	ko:K07533	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_2,Rotamase_3,SurA_N_3
HKD2_k127_10118740_0	1235794.C811_00761	0.0	1115.0	COG1197@1|root,COG1197@2|Bacteria,2GJ42@201174|Actinobacteria,4CV3I@84998|Coriobacteriia	84998|Coriobacteriia	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
HKD2_k127_10118740_10	1173028.ANKO01000065_gene5587	7.497e-70	253.0	COG0177@1|root,COG0177@2|Bacteria,1G1VI@1117|Cyanobacteria,1H8MW@1150|Oscillatoriales	1117|Cyanobacteria	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD
HKD2_k127_10118740_11	243231.GSU0758	4.732e-59	213.0	COG1811@1|root,COG1811@2|Bacteria,1MX1D@1224|Proteobacteria,42S9G@68525|delta/epsilon subdivisions,2WNUQ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Protein of unknown function (DUF554)	-	-	-	ko:K07150	-	-	-	-	ko00000	-	-	-	DUF554
HKD2_k127_10118740_19	1352941.M877_08150	0.0001997	51.0	COG1051@1|root,COG1051@2|Bacteria,2I2YK@201174|Actinobacteria	201174|Actinobacteria	F	belongs to the nudix hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
HKD2_k127_10118740_14	1200792.AKYF01000020_gene5058	8.172e-30	138.0	COG0726@1|root,COG0726@2|Bacteria,1V6DN@1239|Firmicutes,4HF93@91061|Bacilli,26R68@186822|Paenibacillaceae	91061|Bacilli	G	deacetylase	pdaC	-	3.5.1.104	ko:K22278	-	-	-	-	ko00000,ko01000	-	-	-	Polysacc_deac_1
HKD2_k127_10118740_17	1476583.DEIPH_ctg024orf0018	7.512e-08	55.0	COG1225@1|root,COG1225@2|Bacteria,1WJBQ@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	O	Alkyl hydroperoxide reductase	-	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
HKD2_k127_10118740_15	1297742.A176_01698	3.962e-21	96.0	COG1225@1|root,COG1225@2|Bacteria,1RD4R@1224|Proteobacteria,42RHG@68525|delta/epsilon subdivisions,2WQ59@28221|Deltaproteobacteria,2YV5F@29|Myxococcales	28221|Deltaproteobacteria	O	Redoxin	prx-4	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
HKD2_k127_10118740_16	388399.SSE37_13778	4.537e-16	87.0	COG3794@1|root,COG3794@2|Bacteria,1RI9G@1224|Proteobacteria,2U7KA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	PFAM blue (type 1) copper domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Copper-bind,Cupredoxin_1
HKD2_k127_10118740_2	101510.RHA1_ro05854	6.211e-117	401.0	COG1331@1|root,COG1331@2|Bacteria,2GJ88@201174|Actinobacteria,4FTX0@85025|Nocardiaceae	201174|Actinobacteria	O	Protein of unknown function, DUF255	-	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	GlcNAc_2-epim,Thioredox_DsbH
HKD2_k127_10118740_4	1242864.D187_003909	1.037e-103	359.0	COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,42MGZ@68525|delta/epsilon subdivisions,2WIY6@28221|Deltaproteobacteria,2YU80@29|Myxococcales	28221|Deltaproteobacteria	JKL	Belongs to the DEAD box helicase family	-	-	3.6.4.13	ko:K11927	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DEAD,Helicase_C
HKD2_k127_10118740_6	1118054.CAGW01000015_gene4585	1.195e-102	361.0	COG2008@1|root,COG2008@2|Bacteria,1TPZI@1239|Firmicutes,4HA1R@91061|Bacilli,26UBS@186822|Paenibacillaceae	91061|Bacilli	E	Threonine aldolase	ltaE	-	4.1.2.48	ko:K01620	ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230	-	R00751,R06171	RC00312,RC00372	ko00000,ko00001,ko01000	-	-	-	Beta_elim_lyase
HKD2_k127_10118740_12	383372.Rcas_2595	2.218e-50	183.0	COG4420@1|root,COG4420@2|Bacteria,2GAPG@200795|Chloroflexi,376QD@32061|Chloroflexia	32061|Chloroflexia	S	Protein of unknown function (DUF1003)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1003
HKD2_k127_10118740_9	56780.SYN_02059	8.904e-72	254.0	COG2006@1|root,COG2006@2|Bacteria,1QMGX@1224|Proteobacteria,42PRJ@68525|delta/epsilon subdivisions,2WMFN@28221|Deltaproteobacteria,2MQHV@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
HKD2_k127_10118740_8	706587.Desti_2549	5.557e-81	291.0	COG0348@1|root,COG1143@1|root,COG1149@1|root,COG0348@2|Bacteria,COG1143@2|Bacteria,COG1149@2|Bacteria,1QUNB@1224|Proteobacteria,43BMZ@68525|delta/epsilon subdivisions,2X701@28221|Deltaproteobacteria,2MQGZ@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	PFAM 4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_4,Fer4_5
HKD2_k127_10118740_18	525904.Tter_0062	0.0001167	48.0	COG0355@1|root,COG0355@2|Bacteria,2NPSQ@2323|unclassified Bacteria	2|Bacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpC	GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016469,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0045259,GO:0045261,GO:0046034,GO:0046390,GO:0046483,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02114	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_DE,ATP-synt_DE_N
HKD2_k127_10118740_3	910314.HMPREF9220_1310	5.695e-113	370.0	COG0055@1|root,COG0055@2|Bacteria,1TPGF@1239|Firmicutes,4H2IA@909932|Negativicutes	909932|Negativicutes	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits	atpD	-	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_N
HKD2_k127_140563_2	1500257.JQNM01000006_gene1727	9.833e-15	81.0	COG2020@1|root,COG2020@2|Bacteria,1RBFX@1224|Proteobacteria,2U68D@28211|Alphaproteobacteria,4BFU7@82115|Rhizobiaceae	28211|Alphaproteobacteria	O	Isoprenylcysteine carboxyl methyltransferase (ICMT) family	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
HKD2_k127_140563_1	1095772.CAHH01000058_gene1449	2.29e-32	127.0	COG0184@1|root,COG0184@2|Bacteria,2IQA0@201174|Actinobacteria	201174|Actinobacteria	J	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome	rpsO	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0015935,GO:0016020,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071944,GO:1990904	-	ko:K02956	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S15
HKD2_k127_140563_0	491915.Aflv_1689	2.923e-236	749.0	COG1185@1|root,COG1185@2|Bacteria,1TQDW@1239|Firmicutes,4H9Z3@91061|Bacilli,21V27@150247|Anoxybacillus	91061|Bacilli	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004654,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0019222,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901575	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
HKD2_k127_1408760_15	330214.NIDE3962	8.05e-67	236.0	COG0705@1|root,COG0705@2|Bacteria,3J16E@40117|Nitrospirae	40117|Nitrospirae	S	Rhomboid family	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
HKD2_k127_1408760_13	1047013.AQSP01000139_gene2393	2.866e-70	243.0	COG1704@1|root,COG1704@2|Bacteria,2NPIW@2323|unclassified Bacteria	2|Bacteria	S	LemA family	lemA2	-	-	ko:K03744	-	-	-	-	ko00000	-	-	-	LemA
HKD2_k127_1408760_9	1121918.ARWE01000001_gene1102	1.772e-85	292.0	COG0682@1|root,COG0682@2|Bacteria,1MVE3@1224|Proteobacteria,42M2I@68525|delta/epsilon subdivisions,2WMSH@28221|Deltaproteobacteria,43SDM@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Prolipoprotein diacylglyceryl transferase	lgt	-	-	ko:K13292	-	-	-	-	ko00000,ko01000	-	-	-	LGT
HKD2_k127_1408760_16	635013.TherJR_2420	2.308e-56	212.0	COG1470@1|root,COG1470@2|Bacteria,1TRGE@1239|Firmicutes,24EHG@186801|Clostridia	186801|Clostridia	D	Protein of unknown function (DUF3048) C-terminal domain	yerB	-	-	-	-	-	-	-	-	-	-	-	DUF3048,DUF3048_C
HKD2_k127_1408760_2	479437.Elen_1109	3.135e-156	496.0	COG0214@1|root,COG0214@2|Bacteria,2GK1T@201174|Actinobacteria,4CUJ0@84998|Coriobacteriia	84998|Coriobacteriia	H	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively	pdxS	-	4.3.3.6	ko:K06215	ko00750,map00750	-	R07456	RC00010,RC01783,RC03043	ko00000,ko00001,ko01000	-	-	-	SOR_SNZ
HKD2_k127_1408760_14	1123023.JIAI01000029_gene4439	1.746e-68	237.0	COG0311@1|root,COG0311@2|Bacteria,2GNYG@201174|Actinobacteria,4DXHN@85010|Pseudonocardiales	201174|Actinobacteria	H	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS	pdxT	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0008614,GO:0009058,GO:0009108,GO:0009110,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016829,GO:0016840,GO:0016843,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0031668,GO:0032991,GO:0033554,GO:0034641,GO:0040007,GO:0042364,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046184,GO:0046483,GO:0050896,GO:0051186,GO:0051188,GO:0051716,GO:0071496,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617,GO:1902494,GO:1903600	4.3.3.6	ko:K08681	ko00750,map00750	-	R07456	RC00010,RC01783,RC03043	ko00000,ko00001,ko01000	-	-	-	SNO
HKD2_k127_1408760_8	479437.Elen_0967	1.659e-96	326.0	COG0217@1|root,COG0217@2|Bacteria,2GJ4G@201174|Actinobacteria,4CUS6@84998|Coriobacteriia	84998|Coriobacteriia	K	transcriptional regulatory protein	-	-	-	-	-	-	-	-	-	-	-	-	Transcrip_reg
HKD2_k127_1408760_18	521003.COLINT_01977	3.859e-47	176.0	COG0817@1|root,COG0817@2|Bacteria,2GJI5@201174|Actinobacteria,4CVR2@84998|Coriobacteriia	84998|Coriobacteriia	L	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group	ruvC	-	3.1.22.4	ko:K01159	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvC
HKD2_k127_1408760_20	742818.HMPREF9451_00191	1.307e-44	169.0	COG0632@1|root,COG0632@2|Bacteria,2GN17@201174|Actinobacteria,4CVUX@84998|Coriobacteriia	84998|Coriobacteriia	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB	ruvA	-	3.6.4.12	ko:K03550	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HHH_5,RuvA_C,RuvA_N
HKD2_k127_1408760_3	1384484.AEQU_1384	2.679e-154	496.0	COG2255@1|root,COG2255@2|Bacteria,2GJZF@201174|Actinobacteria,4CUPG@84998|Coriobacteriia	84998|Coriobacteriia	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing	ruvB	-	3.6.4.12	ko:K03551	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvB_C,RuvB_N
HKD2_k127_1408760_28	305700.B447_20815	0.0009024	51.0	COG0501@1|root,COG0501@2|Bacteria,1MVU4@1224|Proteobacteria,2VKBX@28216|Betaproteobacteria	28216|Betaproteobacteria	O	peptidase M48, Ste24p	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
HKD2_k127_1408760_26	237368.SCABRO_02453	7.971e-17	87.0	COG2033@1|root,COG2033@2|Bacteria	2|Bacteria	C	superoxide reductase activity	sorA	-	1.15.1.2	ko:K05919	-	-	-	-	ko00000,ko01000	-	-	-	Desulfoferrodox
HKD2_k127_1408760_21	608538.HTH_0124	1.93e-38	155.0	COG1335@1|root,COG1335@2|Bacteria	2|Bacteria	Q	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	pncA	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
HKD2_k127_1408760_7	700015.Corgl_1158	1.06e-102	341.0	COG0190@1|root,COG0190@2|Bacteria,2GJZS@201174|Actinobacteria,4CV1K@84998|Coriobacteriia	84998|Coriobacteriia	F	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate	folD	-	1.5.1.5,3.5.4.9	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R01220,R01655	RC00202,RC00578	ko00000,ko00001,ko00002,ko01000	-	-	-	THF_DHG_CYH,THF_DHG_CYH_C
HKD2_k127_1408760_23	633147.Olsu_0708	1.503e-34	132.0	COG1278@1|root,COG1278@2|Bacteria,2GQRU@201174|Actinobacteria,4CWAW@84998|Coriobacteriia	84998|Coriobacteriia	K	'Cold-shock' DNA-binding domain	-	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
HKD2_k127_1408760_22	1280706.AUJE01000043_gene1630	1.077e-35	145.0	COG2119@1|root,COG2119@2|Bacteria,1UFX2@1239|Firmicutes,4H3Y3@909932|Negativicutes	909932|Negativicutes	S	Uncharacterized protein family UPF0016	-	-	-	-	-	-	-	-	-	-	-	-	UPF0016
HKD2_k127_1408760_19	471855.Shel_07150	2.568e-45	170.0	COG1636@1|root,COG1636@2|Bacteria,2HUPA@201174|Actinobacteria,4CVA0@84998|Coriobacteriia	84998|Coriobacteriia	C	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)	queH	-	1.17.99.6	ko:K09765	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DUF208
HKD2_k127_1408760_24	324602.Caur_3001	1.775e-31	134.0	COG0613@1|root,COG0613@2|Bacteria,2G74N@200795|Chloroflexi,37789@32061|Chloroflexia	32061|Chloroflexia	S	SMART phosphoesterase PHP domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PHP,PHP_C
HKD2_k127_1408760_6	292459.STH1165	1.083e-114	383.0	COG0809@1|root,COG0809@2|Bacteria,1TPKD@1239|Firmicutes,247NT@186801|Clostridia	186801|Clostridia	J	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)	queA	-	2.4.99.17	ko:K07568	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Queuosine_synth
HKD2_k127_1408760_25	552398.HMPREF0866_02379	1.026e-27	120.0	COG1595@1|root,COG1595@2|Bacteria,1TS3M@1239|Firmicutes,24IW2@186801|Clostridia,3WIW4@541000|Ruminococcaceae	186801|Clostridia	K	TIGRFAM RNA polymerase sigma factor, sigma-70 family	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD2_k127_1408760_4	443143.GM18_2293	8.139e-126	416.0	COG0343@1|root,COG0343@2|Bacteria,1MUCA@1224|Proteobacteria,42M5Y@68525|delta/epsilon subdivisions,2WIMT@28221|Deltaproteobacteria,43TNC@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)	tgt	-	2.4.2.29	ko:K00773	-	-	R03789,R10209	RC00063	ko00000,ko01000,ko03016	-	-	-	TGT
HKD2_k127_1408760_27	1869.MB27_26085	2.244e-15	79.0	COG1862@1|root,COG1862@2|Bacteria,2IQSP@201174|Actinobacteria,4DF8H@85008|Micromonosporales	201174|Actinobacteria	U	Preprotein translocase	yajC	-	-	ko:K03210	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	YajC
HKD2_k127_1408760_12	246194.CHY_1513	4.526e-71	249.0	COG3294@1|root,COG3294@2|Bacteria,1UXSS@1239|Firmicutes,24A8Y@186801|Clostridia,42FRF@68295|Thermoanaerobacterales	186801|Clostridia	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	ko:K09163	-	-	-	-	ko00000	-	-	-	HD
HKD2_k127_1408760_5	1111121.HMPREF1247_0185	5.037e-117	392.0	COG0342@1|root,COG0342@2|Bacteria,2GJTT@201174|Actinobacteria,4CUSY@84998|Coriobacteriia	84998|Coriobacteriia	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	-	-	ko:K03072,ko:K12257	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
HKD2_k127_1408760_11	479437.Elen_0984	1.505e-81	282.0	COG0341@1|root,COG0342@1|root,COG0341@2|Bacteria,COG0342@2|Bacteria,2GJTT@201174|Actinobacteria,4CUSY@84998|Coriobacteriia	84998|Coriobacteriia	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	-	-	ko:K03072,ko:K12257	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
HKD2_k127_1408760_0	661087.HMPREF1008_01721	0.0	1062.0	COG0514@1|root,COG0608@1|root,COG0514@2|Bacteria,COG0608@2|Bacteria,2IK2U@201174|Actinobacteria,4CUF5@84998|Coriobacteriia	84998|Coriobacteriia	L	single-stranded-DNA-specific exonuclease RecJ	recJ	-	-	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,DHH,DHHA1,Helicase_C
HKD2_k127_1408760_1	502558.EGYY_25940	7.066e-277	874.0	COG0317@1|root,COG0317@2|Bacteria,2GJYQ@201174|Actinobacteria,4CUQT@84998|Coriobacteriia	84998|Coriobacteriia	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	relA	-	2.7.6.5	ko:K00951	ko00230,map00230	-	R00429	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
HKD2_k127_1408760_17	868595.Desca_2265	2.712e-48	180.0	COG0491@1|root,COG0491@2|Bacteria,1V6FA@1239|Firmicutes,24JGV@186801|Clostridia,261Y2@186807|Peptococcaceae	186801|Clostridia	P	PFAM Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HKD2_k127_1408760_10	748247.AZKH_0382	1.521e-82	282.0	COG0318@1|root,COG0318@2|Bacteria	2|Bacteria	IQ	PFAM AMP-dependent synthetase and ligase	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	LuxE
HKD2_k127_1433654_6	383372.Rcas_2492	2.759e-43	167.0	COG4635@1|root,COG4635@2|Bacteria,2G739@200795|Chloroflexi,377J0@32061|Chloroflexia	32061|Chloroflexia	CH	Flavodoxin domain	-	-	1.3.5.3	ko:K00230	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R09489	RC00885	ko00000,ko00001,ko00002,ko01000	-	-	-	Flavodoxin_5
HKD2_k127_1433654_12	446470.Snas_3927	6.975e-21	100.0	COG1309@1|root,COG1309@2|Bacteria,2GQRD@201174|Actinobacteria,4EZTI@85014|Glycomycetales	201174|Actinobacteria	K	Tetracyclin repressor, C-terminal all-alpha domain	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C,TetR_N
HKD2_k127_1433654_11	512565.AMIS_43080	1.035e-22	103.0	2DRM1@1|root,33C8J@2|Bacteria,2IJ2W@201174|Actinobacteria,4DEIM@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1433654_8	1150864.MILUP08_43252	5.045e-37	143.0	COG3877@1|root,COG3877@2|Bacteria,2IJTS@201174|Actinobacteria,4DDM4@85008|Micromonosporales	201174|Actinobacteria	S	Protein of unknown function (DUF2089)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2089
HKD2_k127_1433654_13	497964.CfE428DRAFT_3646	6.039e-20	99.0	2EEXI@1|root,338QW@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1433654_5	994573.T472_0215410	2.992e-55	210.0	COG0860@1|root,COG0860@2|Bacteria,1UY5Q@1239|Firmicutes,247Y6@186801|Clostridia,36HS7@31979|Clostridiaceae	186801|Clostridia	M	N-acetylmuramoyl-L-alanine amidase	lytC_3	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	Amidase_3,SH3_3
HKD2_k127_1433654_10	1121106.JQKB01000012_gene4682	5.484e-30	134.0	COG0265@1|root,COG0823@1|root,COG2931@1|root,COG0265@2|Bacteria,COG0823@2|Bacteria,COG2931@2|Bacteria	2|Bacteria	Q	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	ko:K08372	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	HemolysinCabind,NACHT,PDZ_2,Trypsin_2,VCBS
HKD2_k127_1433654_9	756499.Desde_3375	1.485e-34	138.0	COG4832@1|root,COG4832@2|Bacteria	2|Bacteria	S	GyrI-like small molecule binding domain	-	-	-	-	-	-	-	-	-	-	-	-	GyrI-like
HKD2_k127_1433654_3	1461580.CCAS010000084_gene4320	1.227e-64	228.0	COG2013@1|root,COG2013@2|Bacteria,1TSVH@1239|Firmicutes,4HD5V@91061|Bacilli,1ZCFB@1386|Bacillus	91061|Bacilli	S	Mitochondrial biogenesis AIM24	-	-	-	-	-	-	-	-	-	-	-	-	AIM24
HKD2_k127_1433654_14	1123393.KB891316_gene2034	2.303e-11	74.0	COG1430@1|root,COG1430@2|Bacteria,1MZBJ@1224|Proteobacteria,2VSCK@28216|Betaproteobacteria,1KRUS@119069|Hydrogenophilales	119069|Hydrogenophilales	S	Uncharacterized ACR, COG1430	-	-	-	ko:K09005	-	-	-	-	ko00000	-	-	-	DUF192
HKD2_k127_1433654_1	56780.SYN_01213	2.9e-86	295.0	COG0549@1|root,COG0549@2|Bacteria,1MWXC@1224|Proteobacteria,42M16@68525|delta/epsilon subdivisions,2WM0V@28221|Deltaproteobacteria,2MRCH@213462|Syntrophobacterales	28221|Deltaproteobacteria	E	Amino acid kinase family	cpkA	-	2.7.2.2	ko:K00926	ko00220,ko00230,ko00910,ko01100,ko01120,ko01200,map00220,map00230,map00910,map01100,map01120,map01200	-	R00150,R01395	RC00002,RC00043,RC02803,RC02804	ko00000,ko00001,ko01000	-	-	-	AA_kinase
HKD2_k127_1433654_0	439481.Aboo_0152	7.192e-154	499.0	COG2403@1|root,arCOG01229@2157|Archaea,2XVYH@28890|Euryarchaeota,3F32N@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	cyclic 2,3-diphosphoglycerate synthetase activity	-	-	-	-	-	-	-	-	-	-	-	-	cobW
HKD2_k127_1433654_2	1499684.CCNP01000023_gene3297	5.384e-73	258.0	COG1307@1|root,COG1307@2|Bacteria,1TRM7@1239|Firmicutes,24A46@186801|Clostridia,36DY9@31979|Clostridiaceae	186801|Clostridia	S	DegV family	-	-	-	-	-	-	-	-	-	-	-	-	DegV
HKD2_k127_1433654_4	1034345.CAEM01000023_gene860	4.792e-59	218.0	COG1307@1|root,COG1307@2|Bacteria,2HG5U@201174|Actinobacteria,4CUCC@84998|Coriobacteriia	84998|Coriobacteriia	S	TIGRFAM degV family protein	-	-	-	-	-	-	-	-	-	-	-	-	DegV
HKD2_k127_1433654_7	1121106.JQKB01000012_gene4682	1.961e-39	158.0	COG0265@1|root,COG0823@1|root,COG2931@1|root,COG0265@2|Bacteria,COG0823@2|Bacteria,COG2931@2|Bacteria	2|Bacteria	Q	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	ko:K08372	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	HemolysinCabind,NACHT,PDZ_2,Trypsin_2,VCBS
HKD2_k127_1437130_0	742818.HMPREF9451_00832	6.194e-154	499.0	COG0488@1|root,COG0488@2|Bacteria,2GKQ4@201174|Actinobacteria,4CU9B@84998|Coriobacteriia	84998|Coriobacteriia	S	ABC transporter	-	-	-	ko:K06158	-	-	-	-	ko00000,ko03012	-	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
HKD2_k127_1437130_4	500153.JOEK01000005_gene2177	5.566e-17	87.0	COG0838@1|root,COG0838@2|Bacteria,2IFDT@201174|Actinobacteria	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain	nuoA2	-	1.6.5.3	ko:K00330	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q4
HKD2_k127_1437130_2	1128427.KB904821_gene3290	1.917e-50	189.0	COG0377@1|root,COG0377@2|Bacteria,1G04A@1117|Cyanobacteria,1H8J8@1150|Oscillatoriales	1117|Cyanobacteria	C	electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and or the photosynthetic chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient. Cyanobacterial NDH-1 also plays a role in inorganic carbon- concentration	ndhK	-	1.6.5.3	ko:K05582	ko00190,ko01100,map00190,map01100	M00145	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	-	-	iJN678.ndhK	Oxidored_q6
HKD2_k127_1437130_3	671143.DAMO_2711	1.698e-31	128.0	COG0852@1|root,COG0852@2|Bacteria,2NPN6@2323|unclassified Bacteria	2|Bacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoC	GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564	1.6.5.3	ko:K00332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa
HKD2_k127_1437130_1	498761.HM1_2199	1.45e-120	403.0	COG0649@1|root,COG0649@2|Bacteria,1TQAR@1239|Firmicutes,24EDV@186801|Clostridia	186801|Clostridia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoD	-	1.6.5.3	ko:K00333	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa
HKD2_k127_1437130_5	469371.Tbis_0288	1.182e-15	82.0	COG1005@1|root,COG1005@2|Bacteria,2GIVY@201174|Actinobacteria,4DYNI@85010|Pseudonocardiales	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	nuoH	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	iNJ661.Rv3152	Fer4,NADHdh
HKD2_k127_1769284_7	926564.KI911641_gene2381	2.916e-11	77.0	COG3437@1|root,COG5002@1|root,COG3437@2|Bacteria,COG5002@2|Bacteria,2GIX7@201174|Actinobacteria,4F38U@85017|Promicromonosporaceae	201174|Actinobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
HKD2_k127_1769284_3	580332.Slit_1455	3.278e-75	277.0	COG0834@1|root,COG2203@1|root,COG5001@1|root,COG0834@2|Bacteria,COG2203@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,44WBU@713636|Nitrosomonadales	28216|Betaproteobacteria	T	Diguanylate cyclase phosphodiesterase with PAS PAC and GAF sensor(S)	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GAF_2,GGDEF,PAS,PAS_4,PAS_9,SBP_bac_3
HKD2_k127_1769284_1	926692.AZYG01000011_gene1122	2.217e-186	601.0	COG0119@1|root,COG0119@2|Bacteria,1TRIK@1239|Firmicutes,249Q4@186801|Clostridia,3WACK@53433|Halanaerobiales	186801|Clostridia	E	Belongs to the alpha-IPM synthase homocitrate synthase family	leuA3	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
HKD2_k127_1769284_2	340099.Teth39_2012	2.22e-82	287.0	COG0179@1|root,COG0179@2|Bacteria,1TQDQ@1239|Firmicutes,248AJ@186801|Clostridia,42F3V@68295|Thermoanaerobacterales	186801|Clostridia	Q	PFAM fumarylacetoacetate (FAA) hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	DUF2437,FAA_hydrolase
HKD2_k127_1769284_4	1229780.BN381_80314	8.712e-48	190.0	COG0477@1|root,COG2814@2|Bacteria,2I2EY@201174|Actinobacteria,3UXSW@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
HKD2_k127_1769284_6	883156.HMPREF9282_01376	5.795e-27	113.0	COG4496@1|root,COG4496@2|Bacteria,1VA04@1239|Firmicutes,4H53N@909932|Negativicutes	909932|Negativicutes	S	TrpR family protein YerC YecD	-	-	-	-	-	-	-	-	-	-	-	-	Trp_repressor
HKD2_k127_1769284_0	469378.Ccur_12030	4.924e-308	970.0	COG0587@1|root,COG0587@2|Bacteria,2GJ1P@201174|Actinobacteria,4CV21@84998|Coriobacteriia	84998|Coriobacteriia	L	DNA polymerase III alpha subunit	-	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
HKD2_k127_1769284_5	742818.HMPREF9451_01298	1.303e-44	170.0	COG0587@1|root,COG0587@2|Bacteria,2GJ1P@201174|Actinobacteria,4CV21@84998|Coriobacteriia	84998|Coriobacteriia	L	DNA polymerase III alpha subunit	-	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
HKD2_k127_1849564_14	1206737.BAGF01000081_gene5197	1.041e-13	78.0	COG0702@1|root,COG0702@2|Bacteria,2IGGT@201174|Actinobacteria,4G935@85025|Nocardiaceae	201174|Actinobacteria	GM	RmlD substrate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_10
HKD2_k127_1849564_6	445975.COLSTE_02228	1.656e-69	238.0	COG0041@1|root,COG0041@2|Bacteria,2IFFD@201174|Actinobacteria,4CVVV@84998|Coriobacteriia	84998|Coriobacteriia	F	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)	purE	-	5.4.99.18	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07405	RC01947	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRC
HKD2_k127_1849564_1	479437.Elen_0037	4.903e-178	572.0	COG0635@1|root,COG0635@2|Bacteria,2GJ2W@201174|Actinobacteria,4CVEC@84998|Coriobacteriia	84998|Coriobacteriia	H	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
HKD2_k127_1849564_2	1203602.HMPREF1527_01133	1.511e-149	484.0	COG0151@1|root,COG0151@2|Bacteria,2I2F5@201174|Actinobacteria,4CU8J@84998|Coriobacteriia	84998|Coriobacteriia	F	Belongs to the GARS family	purD	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	DegV,GARS_A,GARS_C,GARS_N
HKD2_k127_1849564_0	469378.Ccur_11510	7.656e-190	602.0	COG0104@1|root,COG0104@2|Bacteria,2GMP4@201174|Actinobacteria,4CUX7@84998|Coriobacteriia	84998|Coriobacteriia	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	-	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
HKD2_k127_1849564_13	1121019.AUMN01000038_gene23	2.96e-14	78.0	COG1359@1|root,COG1359@2|Bacteria	2|Bacteria	S	Antibiotic biosynthesis monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	ABM
HKD2_k127_1849564_9	192952.MM_3140	5.839e-36	142.0	COG4635@1|root,arCOG00524@2157|Archaea,2Y1YN@28890|Euryarchaeota,2NB42@224756|Methanomicrobia	224756|Methanomicrobia	C	Flavodoxin domain	-	-	1.3.5.3	ko:K00230	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R09489	RC00885	ko00000,ko00001,ko00002,ko01000	-	-	-	Flavodoxin_5
HKD2_k127_1849564_8	679926.Mpet_1639	4.833e-53	196.0	COG2020@1|root,arCOG03580@2157|Archaea,2Y4MT@28890|Euryarchaeota	28890|Euryarchaeota	O	PFAM Isoprenylcysteine carboxyl methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	ICMT
HKD2_k127_1849564_11	869210.Marky_1116	2.698e-27	118.0	COG1510@1|root,COG1510@2|Bacteria,1WKHD@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	K	regulation of RNA biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
HKD2_k127_1849564_5	1278078.G419_20940	1.878e-81	276.0	2DBX9@1|root,2ZBN9@2|Bacteria,2I98J@201174|Actinobacteria,4G1XB@85025|Nocardiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1849564_10	1111121.HMPREF1247_0208	1.116e-29	119.0	COG1278@1|root,COG1278@2|Bacteria,2GQRU@201174|Actinobacteria,4CWDJ@84998|Coriobacteriia	84998|Coriobacteriia	K	'Cold-shock' DNA-binding domain	-	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
HKD2_k127_1849564_3	177439.DP1382	3.492e-113	376.0	COG1162@1|root,COG1162@2|Bacteria,1MUEF@1224|Proteobacteria,42MQV@68525|delta/epsilon subdivisions,2WIZC@28221|Deltaproteobacteria,2MIQG@213118|Desulfobacterales	28221|Deltaproteobacteria	S	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit	rsgA	-	3.1.3.100	ko:K06949	ko00730,ko01100,map00730,map01100	-	R00615,R02135	RC00002,RC00017	ko00000,ko00001,ko01000,ko03009	-	-	-	RsgA_GTPase
HKD2_k127_1849564_7	754476.Q7A_2685	5.375e-54	191.0	COG4898@1|root,COG4898@2|Bacteria,1RHGW@1224|Proteobacteria,1S7UZ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF2200
HKD2_k127_1849564_4	255470.cbdbA1152	1.845e-97	329.0	COG2267@1|root,COG2267@2|Bacteria	2|Bacteria	I	carboxylic ester hydrolase activity	-	-	3.5.1.106	ko:K15357	ko00760,ko01120,map00760,map01120	M00622	R09126	RC00323,RC02431	ko00000,ko00001,ko00002,ko01000	-	-	-	Abhydrolase_1,Abhydrolase_3,Abhydrolase_6,Hydrolase_4
HKD2_k127_1849564_12	368407.Memar_1122	6.061e-18	88.0	COG0454@1|root,arCOG00844@2157|Archaea,2Y70V@28890|Euryarchaeota,2NB0F@224756|Methanomicrobia	224756|Methanomicrobia	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_10
HKD2_k127_192098_21	635013.TherJR_0705	6.828e-26	114.0	COG0004@1|root,COG0004@2|Bacteria,1TQYG@1239|Firmicutes,247W1@186801|Clostridia,2615C@186807|Peptococcaceae	186801|Clostridia	P	TIGRFAM Ammonium transporter	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
HKD2_k127_192098_0	383372.Rcas_0561	3.036e-172	561.0	COG0531@1|root,COG0531@2|Bacteria,2G5ZF@200795|Chloroflexi,37597@32061|Chloroflexia	32061|Chloroflexia	E	Amino acid permease	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
HKD2_k127_192098_13	742742.HMPREF9452_01920	5.754e-42	172.0	COG0477@1|root,COG2814@2|Bacteria	2|Bacteria	EGP	Major facilitator Superfamily	-	-	-	ko:K03291	-	-	-	-	ko00000,ko02000	2.A.1.20	-	-	MFS_1
HKD2_k127_192098_9	644968.DFW101_1721	2.504e-56	205.0	COG0518@1|root,COG0518@2|Bacteria,1MUDH@1224|Proteobacteria,42RU1@68525|delta/epsilon subdivisions,2WNHA@28221|Deltaproteobacteria,2MAGU@213115|Desulfovibrionales	28221|Deltaproteobacteria	F	PFAM Glutamine amidotransferase class-I	-	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase
HKD2_k127_192098_3	697281.Mahau_1271	2.659e-105	353.0	COG1131@1|root,COG1131@2|Bacteria,1TPMQ@1239|Firmicutes,248QD@186801|Clostridia,42FQ5@68295|Thermoanaerobacterales	186801|Clostridia	V	pfam abc	-	-	-	ko:K01990,ko:K09695	ko02010,map02010	M00252,M00254	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.102	-	-	ABC_tran
HKD2_k127_192098_12	926569.ANT_08160	2.313e-44	176.0	COG0842@1|root,COG0842@2|Bacteria,2G774@200795|Chloroflexi	200795|Chloroflexi	V	PFAM ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
HKD2_k127_192098_15	697281.Mahau_1273	8.955e-38	165.0	COG0842@1|root,COG1511@1|root,COG0842@2|Bacteria,COG1511@2|Bacteria,1UZU6@1239|Firmicutes,24BPW@186801|Clostridia,42FHA@68295|Thermoanaerobacterales	186801|Clostridia	V	PFAM ABC-2 type transporter	sagI	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
HKD2_k127_192098_5	706587.Desti_2480	2.497e-70	244.0	COG4912@1|root,COG4912@2|Bacteria,1RGVM@1224|Proteobacteria,42ZZV@68525|delta/epsilon subdivisions,2WVCM@28221|Deltaproteobacteria,2MRS8@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	DNA alkylation repair enzyme	-	-	-	-	-	-	-	-	-	-	-	-	DNA_alkylation
HKD2_k127_192098_4	1121920.AUAU01000008_gene1566	9.371e-86	301.0	COG0697@1|root,COG0697@2|Bacteria,3Y5RD@57723|Acidobacteria	57723|Acidobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HKD2_k127_192098_24	661478.OP10G_4113	6.262e-11	75.0	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	-	GO:0003674,GO:0003824,GO:0016740,GO:0016746,GO:0016747	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HKD2_k127_192098_22	1343739.PAP_01590	3.552e-21	96.0	COG1254@1|root,arCOG01674@2157|Archaea,2XYT5@28890|Euryarchaeota,2449Y@183968|Thermococci	183968|Thermococci	C	acylphosphatase activity	acyP	GO:0003674,GO:0003824,GO:0003998,GO:0016787,GO:0016817,GO:0016818	3.6.1.7	ko:K01512	ko00620,ko00627,ko01120,map00620,map00627,map01120	-	R00317,R01421,R01515	RC00043	ko00000,ko00001,ko01000	-	-	-	Acylphosphatase
HKD2_k127_192098_7	1384484.AEQU_1637	7.134e-65	231.0	COG1272@1|root,COG1272@2|Bacteria,2GJGQ@201174|Actinobacteria,4CV73@84998|Coriobacteriia	84998|Coriobacteriia	S	channel protein, hemolysin III family	-	-	-	ko:K11068	-	-	-	-	ko00000,ko02042	-	-	-	HlyIII
HKD2_k127_192098_11	555088.DealDRAFT_2075	4.774e-53	202.0	arCOG03165@1|root,30AIC@2|Bacteria,1V7NB@1239|Firmicutes,24M5X@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_192098_8	868131.MSWAN_1874	2.21e-63	239.0	COG2041@1|root,arCOG00266@2157|Archaea	2157|Archaea	P	COG2041 Sulfite oxidase and related enzymes	-	-	-	-	-	-	-	-	-	-	-	-	Ni_hydr_CYTB,Oxidored_molyb
HKD2_k127_192098_16	1336208.JADY01000006_gene591	1.441e-37	160.0	COG1018@1|root,COG1018@2|Bacteria,1RF85@1224|Proteobacteria,2UBB2@28211|Alphaproteobacteria,2JU9J@204441|Rhodospirillales	204441|Rhodospirillales	C	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_192098_14	1049564.TevJSym_aw00340	4.811e-40	154.0	COG1047@1|root,COG1047@2|Bacteria,1RD35@1224|Proteobacteria,1S3QR@1236|Gammaproteobacteria,1J67K@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	O	COG1047 FKBP-type peptidyl-prolyl cis-trans isomerases 2	slyD	-	5.2.1.8	ko:K03775	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	FKBP_C
HKD2_k127_192098_27	1267005.KB911257_gene810	0.0002306	49.0	COG3682@1|root,COG3682@2|Bacteria,1N6UP@1224|Proteobacteria,2UJ72@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_192098_18	1379270.AUXF01000006_gene169	1.369e-34	148.0	COG2206@1|root,COG2206@2|Bacteria,1ZUTT@142182|Gemmatimonadetes	142182|Gemmatimonadetes	T	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	-	-	-	-	-	-	-	-	-	HD
HKD2_k127_192098_2	742722.HMPREF9463_00109	1.025e-118	402.0	COG1253@1|root,COG1253@2|Bacteria,2GKN5@201174|Actinobacteria,4CUYP@84998|Coriobacteriia	84998|Coriobacteriia	S	Transporter associated domain	-	-	-	ko:K03699	-	-	-	-	ko00000,ko02042	-	-	-	CBS,CorC_HlyC,DUF21
HKD2_k127_192098_26	871963.Desdi_0983	2.312e-06	59.0	2DPQR@1|root,3330J@2|Bacteria,1VF83@1239|Firmicutes,25EKT@186801|Clostridia,2645C@186807|Peptococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_192098_25	1122918.KB907245_gene5259	6.881e-10	68.0	COG1983@1|root,COG1983@2|Bacteria,1VKBQ@1239|Firmicutes,4HRGW@91061|Bacilli,26ZXM@186822|Paenibacillaceae	91061|Bacilli	KT	Phage-shock protein	yvlC	-	-	ko:K03973	-	-	-	-	ko00000,ko02048,ko03000	-	-	-	DUF4097,PspC
HKD2_k127_192098_17	1122223.KB890700_gene1905	5.195e-36	149.0	COG2159@1|root,COG2159@2|Bacteria	2|Bacteria	E	amidohydrolase	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
HKD2_k127_192098_20	926569.ANT_00580	5.725e-28	131.0	COG2227@1|root,COG2227@2|Bacteria,2G9HD@200795|Chloroflexi	200795|Chloroflexi	H	PFAM Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
HKD2_k127_192098_19	298655.KI912266_gene5657	3.995e-30	128.0	COG0424@1|root,COG0424@2|Bacteria,2GNI0@201174|Actinobacteria	201174|Actinobacteria	D	Maf-like protein	maf	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	-	ko:K06287	-	-	-	-	ko00000	-	-	-	Maf,NUDIX
HKD2_k127_192098_23	269799.Gmet_2816	1.432e-17	98.0	COG1413@1|root,COG1413@2|Bacteria,1N5TU@1224|Proteobacteria,42UDF@68525|delta/epsilon subdivisions,2WQ3K@28221|Deltaproteobacteria,43TQ4@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2
HKD2_k127_192098_10	243231.GSU0287	2.459e-54	220.0	COG2206@1|root,COG2206@2|Bacteria,1MW7F@1224|Proteobacteria,42PHB@68525|delta/epsilon subdivisions,2WMJX@28221|Deltaproteobacteria,43S0A@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	PFAM metal-dependent phosphohydrolase HD sub domain	-	-	-	-	-	-	-	-	-	-	-	-	HD,HD_5,KOW
HKD2_k127_192098_1	298654.FraEuI1c_0777	7.24e-164	538.0	COG1615@1|root,COG1615@2|Bacteria,2GMP3@201174|Actinobacteria,4ERVJ@85013|Frankiales	201174|Actinobacteria	S	Uncharacterised protein family (UPF0182)	-	GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	ko:K09118	-	-	-	-	ko00000	-	-	-	UPF0182
HKD2_k127_192098_6	1541065.JRFE01000014_gene1779	8.442e-70	244.0	COG1615@1|root,COG1615@2|Bacteria,1G05D@1117|Cyanobacteria,3VIF0@52604|Pleurocapsales	1117|Cyanobacteria	S	Uncharacterised protein family (UPF0182)	-	-	-	ko:K09118	-	-	-	-	ko00000	-	-	-	UPF0182
HKD2_k127_1931731_20	379066.GAU_0964	6.028e-47	176.0	COG0514@1|root,COG0514@2|Bacteria,1ZUBS@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	RecQ zinc-binding	-	-	3.6.4.12	ko:K03654	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,HRDC,Helicase_C,RecQ_Zn_bind
HKD2_k127_1931731_6	1121866.AUGK01000004_gene218	6.084e-101	343.0	COG0349@1|root,COG0349@2|Bacteria,2GKNM@201174|Actinobacteria,4CV2Q@84998|Coriobacteriia	84998|Coriobacteriia	J	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides	rnd	-	3.1.13.5	ko:K03684	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DNA_pol_A_exo1,HRDC
HKD2_k127_1931731_15	502558.EGYY_13080	8.351e-68	244.0	COG1597@1|root,COG1597@2|Bacteria,2HH18@201174|Actinobacteria,4CUXW@84998|Coriobacteriia	84998|Coriobacteriia	I	diacylglycerol kinase catalytic	-	-	-	-	-	-	-	-	-	-	-	-	DAGK_cat
HKD2_k127_1931731_13	661087.HMPREF1008_01875	1.894e-76	281.0	COG4907@1|root,COG4907@2|Bacteria,2HUJ8@201174|Actinobacteria,4CUWT@84998|Coriobacteriia	84998|Coriobacteriia	S	Predicted membrane protein (DUF2207)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2207
HKD2_k127_1931731_25	661087.HMPREF1008_01229	6.967e-33	132.0	COG1278@1|root,COG1278@2|Bacteria,2GQRU@201174|Actinobacteria,4CWAW@84998|Coriobacteriia	84998|Coriobacteriia	K	'Cold-shock' DNA-binding domain	-	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
HKD2_k127_1931731_29	1123288.SOV_4c02030	7.511e-22	105.0	COG0810@1|root,COG5263@1|root,COG0810@2|Bacteria,COG5263@2|Bacteria,1V30N@1239|Firmicutes,4H8HT@909932|Negativicutes	909932|Negativicutes	M	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1931731_35	1304875.JAFZ01000004_gene476	2.473e-10	66.0	2DD8T@1|root,2ZH33@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1931731_21	1232410.KI421424_gene1824	8.073e-47	175.0	COG0163@1|root,COG0163@2|Bacteria,1RA0P@1224|Proteobacteria,42QXP@68525|delta/epsilon subdivisions,2WP9I@28221|Deltaproteobacteria,43SFU@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN	ubiX	-	2.5.1.129	ko:K03186	ko00130,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00627,map00940,map01100,map01110,map01120,map01220	M00117	R01238,R02952,R03367,R04985,R04986,R11225	RC00391,RC00814,RC03392	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_3392	Flavoprotein
HKD2_k127_1931731_31	109760.SPPG_05457T0	1.359e-16	94.0	COG1524@1|root,KOG2126@2759|Eukaryota	2759|Eukaryota	U	mannose-ethanolamine phosphotransferase activity	-	-	-	ko:K05288	ko00563,ko01100,map00563,map01100	-	R05923,R08107	RC00017	ko00000,ko00001	-	-	-	Phosphodiest
HKD2_k127_1931731_16	479437.Elen_1751	1.737e-50	187.0	COG1011@1|root,COG1011@2|Bacteria	2|Bacteria	S	phosphatase activity	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2,Hydrolase,Hydrolase_like
HKD2_k127_1931731_28	264732.Moth_1834	4.825e-26	115.0	COG0778@1|root,COG0778@2|Bacteria,1V4UA@1239|Firmicutes,24EVR@186801|Clostridia	186801|Clostridia	C	PFAM Nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase,TM1586_NiRdase
HKD2_k127_1931731_34	717606.PaecuDRAFT_2794	5.841e-11	75.0	COG0707@1|root,COG0707@2|Bacteria,1TR07@1239|Firmicutes,4HBKJ@91061|Bacilli,26SJR@186822|Paenibacillaceae	91061|Bacilli	M	UDP-N-acetylglucosamine LPS N-acetylglucosamine transferase	ugtP	GO:0003674,GO:0003824,GO:0008194,GO:0016740,GO:0016757,GO:0016758,GO:0035251,GO:0046527,GO:0047228	2.4.1.315	ko:K03429	ko00561,ko01100,map00561,map01100	-	R02689,R04377	RC00005,RC00059	ko00000,ko00001,ko01000,ko01003	-	GT28	-	Glyco_tran_28_C,Glycos_transf_1,MGDG_synth
HKD2_k127_1931731_26	742742.HMPREF9452_00050	1.672e-31	134.0	COG1366@1|root,COG2172@1|root,COG1366@2|Bacteria,COG2172@2|Bacteria,2HUNT@201174|Actinobacteria,4CV8A@84998|Coriobacteriia	84998|Coriobacteriia	T	Belongs to the anti-sigma-factor antagonist family	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c_2,STAS,STAS_2
HKD2_k127_1931731_23	1157635.KB892007_gene3161	4.344e-40	173.0	COG2172@1|root,COG2203@1|root,COG2208@1|root,COG2172@2|Bacteria,COG2203@2|Bacteria,COG2208@2|Bacteria,2GKN8@201174|Actinobacteria	201174|Actinobacteria	T	SMART protein phosphatase 2C domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,GAF_3,HATPase_c_2,PAS,PAS_4,SpoIIE
HKD2_k127_1931731_18	1207063.P24_18209	7.397e-49	183.0	COG0785@1|root,COG0785@2|Bacteria,1RCP7@1224|Proteobacteria,2TSAI@28211|Alphaproteobacteria,2JS3U@204441|Rhodospirillales	204441|Rhodospirillales	O	Cytochrome C biogenesis protein transmembrane region	-	-	-	ko:K06196	-	-	-	-	ko00000,ko02000	5.A.1.2	-	-	DsbD
HKD2_k127_1931731_36	634498.mru_0205	9.437e-08	57.0	arCOG02764@1|root,arCOG02764@2157|Archaea	2157|Archaea	S	Heavy-metal-associated domain	-	-	3.6.3.4,3.6.3.54	ko:K01533,ko:K07213,ko:K07496,ko:K17686	ko01524,ko04016,ko04978,map01524,map04016,map04978	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
HKD2_k127_1931731_24	545694.TREPR_0380	7.4e-37	155.0	COG2836@1|root,COG4633@1|root,COG2836@2|Bacteria,COG4633@2|Bacteria,2JA4J@203691|Spirochaetes	203691|Spirochaetes	P	Heavy metal transport detoxification protein	-	-	-	-	-	-	-	-	-	-	-	-	DsbD_2,HMA
HKD2_k127_1931731_3	1125863.JAFN01000001_gene1446	5.397e-133	437.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	ko:K02481	-	-	-	-	ko00000,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD2_k127_1931731_12	293826.Amet_3256	7.583e-79	287.0	COG3852@1|root,COG3852@2|Bacteria,1TRH0@1239|Firmicutes,25F1F@186801|Clostridia,36HP9@31979|Clostridiaceae	186801|Clostridia	T	PFAM ATP-binding region, ATPase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
HKD2_k127_1931731_8	1120973.AQXL01000123_gene3075	5.721e-87	305.0	COG1508@1|root,COG1508@2|Bacteria,1TQ0H@1239|Firmicutes,4HA8T@91061|Bacilli,2788U@186823|Alicyclobacillaceae	91061|Bacilli	K	Sigma-54 factor, Activator interacting domain (AID)	sigL	-	-	ko:K03092	ko02020,ko05111,map02020,map05111	-	-	-	ko00000,ko00001,ko03021	-	-	-	Sigma54_AID,Sigma54_CBD,Sigma54_DBD
HKD2_k127_1931731_27	1121468.AUBR01000002_gene640	5.781e-31	136.0	COG0697@1|root,COG0697@2|Bacteria,1TR6G@1239|Firmicutes,24AMC@186801|Clostridia,42GQW@68295|Thermoanaerobacterales	186801|Clostridia	EG	EamA-like transporter family	yicL	-	-	-	-	-	-	-	-	-	-	-	EamA
HKD2_k127_1931731_32	1265845.PWEIH_15053	1.432e-14	80.0	COG1937@1|root,COG1937@2|Bacteria,1VEF5@1239|Firmicutes,4HKJV@91061|Bacilli,26N3P@186820|Listeriaceae	91061|Bacilli	S	Metal-sensitive transcriptional repressor	csoR	-	-	ko:K21600	-	-	-	-	ko00000,ko03000	-	-	-	Trns_repr_metal
HKD2_k127_1931731_30	264732.Moth_1263	2.68e-18	90.0	COG3439@1|root,COG3439@2|Bacteria,1VA5R@1239|Firmicutes,24NQI@186801|Clostridia	186801|Clostridia	S	Domain of unknown function DUF302	-	-	-	-	-	-	-	-	-	-	-	-	DUF302
HKD2_k127_1931731_22	867845.KI911784_gene2954	8.119e-41	162.0	COG0613@1|root,COG0613@2|Bacteria,2G74N@200795|Chloroflexi,37789@32061|Chloroflexia	32061|Chloroflexia	S	SMART phosphoesterase PHP domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PHP,PHP_C
HKD2_k127_1931731_10	304371.MCP_2273	6.767e-81	298.0	arCOG00787@1|root,arCOG00787@2157|Archaea	2157|Archaea	L	UvrD REP helicase	-	-	3.6.4.12	ko:K03657,ko:K07465	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
HKD2_k127_1931731_4	879212.DespoDRAFT_00692	3.204e-131	431.0	COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,42MKR@68525|delta/epsilon subdivisions,2WJ0U@28221|Deltaproteobacteria,2MI24@213118|Desulfobacterales	28221|Deltaproteobacteria	E	aminotransferase class I and II	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
HKD2_k127_1931731_17	562970.Btus_0402	1.846e-49	200.0	COG1032@1|root,COG1032@2|Bacteria,1TPGT@1239|Firmicutes,4HA0Y@91061|Bacilli,2785E@186823|Alicyclobacillaceae	91061|Bacilli	C	Protein of unknown function (DUF4080)	bchE	-	1.21.98.3	ko:K04034	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R06268,R06269,R06270	RC00741,RC01491,RC01492	ko00000,ko00001,ko01000	-	-	-	B12-binding,DUF4080,Radical_SAM
HKD2_k127_1931731_37	1121861.KB899919_gene2720	5.695e-06	58.0	COG0535@1|root,COG0535@2|Bacteria,1MUQP@1224|Proteobacteria,2TTS5@28211|Alphaproteobacteria,2JRCB@204441|Rhodospirillales	204441|Rhodospirillales	S	Elongator protein 3, MiaB family, Radical SAM	pqqE	-	-	ko:K06139	-	-	-	-	ko00000	-	-	-	Fer4_12,Radical_SAM,SPASM
HKD2_k127_1931731_14	635013.TherJR_2108	1.059e-73	264.0	COG0438@1|root,COG0438@2|Bacteria,1TPY6@1239|Firmicutes,24834@186801|Clostridia,261PX@186807|Peptococcaceae	186801|Clostridia	M	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
HKD2_k127_1931731_1	1118060.CAGZ01000025_gene955	2.724e-141	456.0	COG4608@1|root,COG4608@2|Bacteria,2H4BW@201174|Actinobacteria,4CUUN@84998|Coriobacteriia	84998|Coriobacteriia	P	ABC transporter, ATP-binding protein	-	-	-	ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
HKD2_k127_1931731_5	521045.Kole_1547	4.693e-118	389.0	COG0444@1|root,COG0444@2|Bacteria,2GCKF@200918|Thermotogae	200918|Thermotogae	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
HKD2_k127_1931731_7	266117.Rxyl_0874	2.262e-91	310.0	COG1173@1|root,COG1173@2|Bacteria,2GJ9E@201174|Actinobacteria,4CR71@84995|Rubrobacteria	84995|Rubrobacteria	EP	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
HKD2_k127_1931731_9	266117.Rxyl_0873	4.92e-84	291.0	COG0601@1|root,COG0601@2|Bacteria,2GJ2C@201174|Actinobacteria	201174|Actinobacteria	EP	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
HKD2_k127_1931731_2	266117.Rxyl_0872	9.875e-138	460.0	COG0747@1|root,COG0747@2|Bacteria,2HEVB@201174|Actinobacteria,4CTBY@84995|Rubrobacteria	84995|Rubrobacteria	E	PFAM extracellular solute-binding protein, family 5	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
HKD2_k127_1931731_33	649764.HMPREF0762_00144	8.366e-14	75.0	COG1314@1|root,COG1314@2|Bacteria,2HTTU@201174|Actinobacteria,4CW9B@84998|Coriobacteriia	84998|Coriobacteriia	U	Preprotein translocase SecG subunit	secG	-	-	ko:K03075	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecG
HKD2_k127_1931731_0	742738.HMPREF9460_02020	6.787e-177	574.0	COG0696@1|root,COG0696@2|Bacteria,1TPM4@1239|Firmicutes,247JG@186801|Clostridia,267NF@186813|unclassified Clostridiales	186801|Clostridia	G	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate	gpmI	-	5.4.2.12	ko:K15633	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,Phosphodiest,iPGM_N
HKD2_k127_1931731_11	370438.PTH_2721	9.644e-81	277.0	COG0149@1|root,COG0149@2|Bacteria,1TP2F@1239|Firmicutes,248JN@186801|Clostridia,260CH@186807|Peptococcaceae	186801|Clostridia	G	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)	tpiA	-	5.3.1.1	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01015	RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	TIM
HKD2_k127_1931731_19	502558.EGYY_12910	9.317e-48	174.0	COG0126@1|root,COG0126@2|Bacteria,2GJC6@201174|Actinobacteria,4CUGT@84998|Coriobacteriia	84998|Coriobacteriia	F	Belongs to the phosphoglycerate kinase family	pgk	-	2.7.2.3	ko:K00927	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01512	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
HKD2_k127_2148941_22	768704.Desmer_0641	1.597e-13	79.0	COG4393@1|root,COG4393@2|Bacteria,1VUBT@1239|Firmicutes,2508J@186801|Clostridia,26549@186807|Peptococcaceae	186801|Clostridia	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF2318
HKD2_k127_2148941_19	589924.Ferp_0802	7.659e-20	97.0	COG2010@1|root,arCOG06111@2157|Archaea,2XXGW@28890|Euryarchaeota,2469C@183980|Archaeoglobi	183980|Archaeoglobi	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	Cytochrom_C,Cytochrome_CBB3
HKD2_k127_2148941_24	1185653.A1A1_13572	0.0002171	48.0	COG3462@1|root,COG3462@2|Bacteria,1VKBD@1239|Firmicutes,4HZMW@91061|Bacilli,26I1I@186818|Planococcaceae	91061|Bacilli	S	Short C-terminal domain	-	-	-	ko:K08982	-	-	-	-	ko00000	-	-	-	SHOCT
HKD2_k127_2148941_0	518766.Rmar_1535	8.614e-277	866.0	COG2217@1|root,COG2217@2|Bacteria,4NERS@976|Bacteroidetes,1FIZ6@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	P	heavy metal translocating P-type ATPase	copB	-	3.6.3.4,3.6.3.54	ko:K01533,ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
HKD2_k127_2148941_5	886293.Sinac_7195	9.429e-130	427.0	COG0031@1|root,COG3620@1|root,COG0031@2|Bacteria,COG3620@2|Bacteria,2IY6T@203682|Planctomycetes	203682|Planctomycetes	E	Pyridoxal-phosphate dependent enzyme	-	-	4.2.1.22	ko:K01697	ko00260,ko00270,ko01100,ko01130,ko01230,map00260,map00270,map01100,map01130,map01230	M00035,M00338	R00891,R01290,R04942	RC00056,RC00069,RC00256,RC00489,RC01246	ko00000,ko00001,ko00002,ko01000	-	-	-	CBS,PALP
HKD2_k127_2148941_3	240292.Ava_4155	8.34e-138	458.0	COG0626@1|root,COG0626@2|Bacteria,1G43Q@1117|Cyanobacteria,1HU8Q@1161|Nostocales	1117|Cyanobacteria	E	Cys/Met metabolism PLP-dependent enzyme	metB	-	2.5.1.48,4.4.1.1	ko:K01739,ko:K01758	ko00260,ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00260,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017,M00338	R00782,R00999,R01001,R01288,R02408,R02508,R03217,R03260,R04770,R04930,R04944,R04945,R04946,R09366	RC00020,RC00056,RC00069,RC00348,RC00382,RC00420,RC00710,RC01209,RC01210,RC01245,RC02303,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Cys_Met_Meta_PP
HKD2_k127_2148941_9	1121920.AUAU01000001_gene2168	3.912e-85	291.0	COG2519@1|root,COG2519@2|Bacteria,3Y5T2@57723|Acidobacteria	57723|Acidobacteria	J	Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
HKD2_k127_2148941_15	420324.KI911965_gene823	9.614e-62	222.0	COG2227@1|root,COG2227@2|Bacteria,1QYBJ@1224|Proteobacteria,2TXM3@28211|Alphaproteobacteria,1JR8P@119045|Methylobacteriaceae	28211|Alphaproteobacteria	H	TIGRFAM methionine biosynthesis protein MetW	metW	-	-	-	-	-	-	-	-	-	-	-	MetW
HKD2_k127_2148941_6	420247.Msm_0175	1.256e-125	422.0	COG2021@1|root,arCOG00627@2157|Archaea,2XTYY@28890|Euryarchaeota,23NK8@183925|Methanobacteria	183925|Methanobacteria	E	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine	metXA	-	2.3.1.31	ko:K00641	ko00270,ko01100,ko01130,map00270,map01100,map01130	-	R01776	RC00004,RC00041	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1,CBS
HKD2_k127_2148941_2	1125863.JAFN01000001_gene1046	8.083e-173	553.0	COG2873@1|root,COG2873@2|Bacteria,1NQME@1224|Proteobacteria,43DRR@68525|delta/epsilon subdivisions,2X70U@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	PFAM Cys Met metabolism	metY-2	-	2.5.1.49	ko:K01740	ko00270,ko01100,map00270,map01100	-	R01287,R04859	RC00020,RC02821,RC02848	ko00000,ko00001,ko01000	-	-	-	Cys_Met_Meta_PP
HKD2_k127_2148941_7	1313304.CALK_0073	3.837e-100	338.0	COG0031@1|root,COG0031@2|Bacteria	2|Bacteria	E	Belongs to the cysteine synthase cystathionine beta- synthase family	cysK	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004124,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009333,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0016829,GO:0016846,GO:0019344,GO:0019752,GO:0019842,GO:0030170,GO:0032991,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0080146,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494,GO:1990234	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	iAF1260.b2414,iAPECO1_1312.APECO1_4131,iB21_1397.B21_02275,iBWG_1329.BWG_2176,iE2348C_1286.E2348C_2600,iEC042_1314.EC042_2623,iEC55989_1330.EC55989_2704,iECABU_c1320.ECABU_c27350,iECBD_1354.ECBD_1267,iECB_1328.ECB_02314,iECDH10B_1368.ECDH10B_2579,iECDH1ME8569_1439.ECDH1ME8569_2348,iECD_1391.ECD_02314,iECED1_1282.ECED1_2858,iECH74115_1262.ECH74115_3645,iECIAI1_1343.ECIAI1_2472,iECNA114_1301.ECNA114_2491,iECO103_1326.ECO103_2933,iECO111_1330.ECO111_3144,iECO26_1355.ECO26_3467,iECOK1_1307.ECOK1_2731,iECP_1309.ECP_2438,iECS88_1305.ECS88_2604,iECSE_1348.ECSE_2705,iECSF_1327.ECSF_2278,iECSP_1301.ECSP_3362,iECUMN_1333.ECUMN_2736,iECW_1372.ECW_m2643,iECs_1301.ECs3286,iEKO11_1354.EKO11_1314,iETEC_1333.ETEC_2527,iEcDH1_1363.EcDH1_1247,iEcHS_1320.EcHS_A2549,iEcSMS35_1347.EcSMS35_2569,iEcolC_1368.EcolC_1264,iG2583_1286.G2583_2946,iJO1366.b2414,iJR904.b2414,iLF82_1304.LF82_0418,iNRG857_1313.NRG857_12105,iSSON_1240.SSON_2503,iSbBS512_1146.SbBS512_E2766,iUMN146_1321.UM146_04550,iUMNK88_1353.UMNK88_3016,iUTI89_1310.UTI89_C2747,iWFL_1372.ECW_m2643,iY75_1357.Y75_RS12650,iZ_1308.Z3680	PALP
HKD2_k127_2148941_20	1521187.JPIM01000071_gene2413	5.276e-15	80.0	COG1959@1|root,COG1959@2|Bacteria,2G8ZH@200795|Chloroflexi,375QF@32061|Chloroflexia	32061|Chloroflexia	K	transcriptional regulator, Rrf2 family	-	-	-	-	-	-	-	-	-	-	-	-	Rrf2
HKD2_k127_2148941_16	1125863.JAFN01000001_gene2762	2.372e-42	164.0	COG0235@1|root,COG0235@2|Bacteria,1N84G@1224|Proteobacteria,42RVW@68525|delta/epsilon subdivisions,2WSI5@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	PFAM Class II aldolase	-	-	4.1.2.17	ko:K01628	ko00051,ko01120,map00051,map01120	-	R02262	RC00603,RC00604	ko00000,ko00001,ko01000	-	-	-	Aldolase_II
HKD2_k127_2148941_12	1121272.KB903283_gene5274	5.086e-74	265.0	COG0477@1|root,COG2814@2|Bacteria,2I7XA@201174|Actinobacteria,4DCHW@85008|Micromonosporales	201174|Actinobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD2_k127_2148941_13	1380390.JIAT01000016_gene5527	2.644e-63	234.0	COG0477@1|root,COG2814@2|Bacteria,2I7XA@201174|Actinobacteria	201174|Actinobacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD2_k127_2148941_21	1499967.BAYZ01000017_gene6213	8.989e-15	85.0	COG1413@1|root,COG1413@2|Bacteria,2NRRZ@2323|unclassified Bacteria	2|Bacteria	C	PBS lyase HEAT-like repeat	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,HEAT_PBS,Metallophos,NACHT,Trypsin_2
HKD2_k127_2148941_17	383372.Rcas_0845	2.338e-36	154.0	COG2204@1|root,COG2206@1|root,COG2204@2|Bacteria,COG2206@2|Bacteria,2GBKK@200795|Chloroflexi,3781M@32061|Chloroflexia	32061|Chloroflexia	T	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	HD,Response_reg
HKD2_k127_2148941_11	234621.RER_21890	2.411e-74	270.0	COG3920@1|root,COG3920@2|Bacteria,2GKMP@201174|Actinobacteria,4FZDD@85025|Nocardiaceae	201174|Actinobacteria	T	Signal transduction histidine kinase	pdtaS	GO:0000155,GO:0000160,GO:0000166,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0005488,GO:0005524,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0017076,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035556,GO:0035639,GO:0036094,GO:0036211,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564	2.7.13.3	ko:K00936	-	M00839	-	-	ko00000,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,H_kinase_N,HisKA_2,PAS_4
HKD2_k127_2148941_14	1120948.KB903240_gene4076	1.539e-62	231.0	COG3707@1|root,COG3707@2|Bacteria,2GK7T@201174|Actinobacteria,4DYAM@85010|Pseudonocardiales	201174|Actinobacteria	T	Response regulator receiver	pdtaR	GO:0000160,GO:0003674,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0007154,GO:0007165,GO:0008150,GO:0009987,GO:0016020,GO:0023052,GO:0030312,GO:0035556,GO:0040007,GO:0043167,GO:0043168,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0071944	-	ko:K22010	-	M00839	-	-	ko00000,ko00002,ko02022	-	-	-	ANTAR,Response_reg
HKD2_k127_2148941_23	555088.DealDRAFT_2813	2.139e-06	60.0	28U8H@1|root,2ZGE4@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2148941_8	246194.CHY_0714	8.036e-97	333.0	COG1150@1|root,COG2048@1|root,COG1150@2|Bacteria,COG2048@2|Bacteria,1V67B@1239|Firmicutes,248DI@186801|Clostridia,42H12@68295|Thermoanaerobacterales	186801|Clostridia	C	Cysteine-rich domain	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03389	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG
HKD2_k127_2148941_4	373903.Hore_16310	1.317e-137	459.0	COG0067@1|root,COG0067@2|Bacteria,1TQX1@1239|Firmicutes,24AKF@186801|Clostridia,3WB3R@53433|Halanaerobiales	186801|Clostridia	C	Glutamate synthase (NADPH) GltB1 subunit	-	-	-	-	-	-	-	-	-	-	-	-	GATase_2,GATase_6
HKD2_k127_2148941_1	246194.CHY_0707	3.306e-219	711.0	COG0069@1|root,COG0069@2|Bacteria,1TQ0B@1239|Firmicutes,248IB@186801|Clostridia,42EK3@68295|Thermoanaerobacterales	186801|Clostridia	C	Belongs to the glutamate synthase family	gltB	-	1.4.1.13,1.4.1.14	ko:K00265	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4,Fer4_7,Fer4_9,Glu_syn_central,Glu_synthase
HKD2_k127_2148941_10	477974.Daud_2024	1.912e-83	286.0	COG0070@1|root,COG0070@2|Bacteria,1TQEB@1239|Firmicutes,24AQ1@186801|Clostridia,261IX@186807|Peptococcaceae	186801|Clostridia	E	PFAM glutamate synthase alpha subunit	-	-	-	-	-	-	-	-	-	-	-	-	GXGXG
HKD2_k127_2148941_18	431943.CKL_1095	5.431e-21	107.0	COG5017@1|root,COG5017@2|Bacteria,1V2RT@1239|Firmicutes,24NVB@186801|Clostridia,36MR2@31979|Clostridiaceae	186801|Clostridia	M	D-glucuronyl C5-epimerase C-terminus	-	-	-	-	-	-	-	-	-	-	-	-	C5-epim_C
HKD2_k127_2197221_10	401526.TcarDRAFT_1038	3.593e-30	129.0	COG1364@1|root,COG1364@2|Bacteria,1TPBP@1239|Firmicutes,4H2TK@909932|Negativicutes	909932|Negativicutes	E	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate	argJ	-	2.3.1.1,2.3.1.35	ko:K00620	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259,R02282	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	ArgJ
HKD2_k127_2197221_5	519989.ECTPHS_02369	1.026e-94	321.0	COG0002@1|root,COG0002@2|Bacteria,1MVJ6@1224|Proteobacteria,1RNMX@1236|Gammaproteobacteria,1WWVX@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde	argC	-	1.2.1.38	ko:K00145	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R03443	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
HKD2_k127_2197221_1	479437.Elen_2360	5.933e-246	784.0	COG0072@1|root,COG0073@1|root,COG0072@2|Bacteria,COG0073@2|Bacteria,2GMFD@201174|Actinobacteria,4CUQ6@84998|Coriobacteriia	84998|Coriobacteriia	J	Phenylalanyl-tRNA synthetase, beta subunit	pheT	-	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,tRNA_bind
HKD2_k127_2197221_3	742818.HMPREF9451_00260	1.014e-149	482.0	COG0016@1|root,COG0016@2|Bacteria,2GJGG@201174|Actinobacteria,4CUGV@84998|Coriobacteriia	84998|Coriobacteriia	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily	pheS	-	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Phe_tRNA-synt_N,tRNA-synt_2d
HKD2_k127_2197221_12	446462.Amir_4390	6.525e-06	57.0	COG0681@1|root,COG0681@2|Bacteria,2GQPQ@201174|Actinobacteria,4E7E2@85010|Pseudonocardiales	201174|Actinobacteria	U	Peptidase S24-like	-	-	3.4.21.89	ko:K13280	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	DUF3494,Laminin_G_3,Peptidase_S24
HKD2_k127_2197221_0	56780.SYN_02218	0.0	1023.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,42M8F@68525|delta/epsilon subdivisions,2WIU0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
HKD2_k127_2197221_2	1123392.AQWL01000010_gene2312	1.535e-161	523.0	COG2211@1|root,COG2211@2|Bacteria,1QVH9@1224|Proteobacteria,2WGR7@28216|Betaproteobacteria,1KSBE@119069|Hydrogenophilales	119069|Hydrogenophilales	G	Sugar (and other) transporter	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD2_k127_2197221_8	742818.HMPREF9451_00448	1.004e-51	184.0	COG0292@1|root,COG0292@2|Bacteria,2IHTN@201174|Actinobacteria,4CVXQ@84998|Coriobacteriia	84998|Coriobacteriia	J	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit	rplT	-	-	ko:K02887	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L20
HKD2_k127_2197221_11	502558.EGYY_11720	4.049e-17	83.0	COG0291@1|root,COG0291@2|Bacteria,2HV94@201174|Actinobacteria,4CWHW@84998|Coriobacteriia	84998|Coriobacteriia	J	Belongs to the bacterial ribosomal protein bL35 family	rpmI	-	-	ko:K02916	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L35p
HKD2_k127_2197221_6	445975.COLSTE_01352	5.336e-76	260.0	COG0290@1|root,COG0290@2|Bacteria,2GJGT@201174|Actinobacteria,4CUA6@84998|Coriobacteriia	84998|Coriobacteriia	J	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins	infC	-	-	ko:K02520	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	IF3_C,IF3_N
HKD2_k127_2197221_4	2325.TKV_c18800	6.564e-112	383.0	COG0642@1|root,COG2205@2|Bacteria,1TQHB@1239|Firmicutes,247S4@186801|Clostridia,42EMD@68295|Thermoanaerobacterales	186801|Clostridia	T	PFAM Signal transduction histidine kinase, osmosensitive K channel sensor, N-terminal	-	-	2.7.13.3	ko:K07646	ko02020,map02020	M00454	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	DUF4118,GAF_3,HATPase_c,HisKA,KdpD,Usp
HKD2_k127_2197221_9	1331060.RLDS_13070	9.422e-49	187.0	COG2156@1|root,COG2156@2|Bacteria,1RABG@1224|Proteobacteria,2TSQ7@28211|Alphaproteobacteria,2K2ZB@204457|Sphingomonadales	204457|Sphingomonadales	P	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex	kdpC	-	3.6.3.12	ko:K01548	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	3.A.3.7	-	-	KdpC
HKD2_k127_2197221_7	1247649.D560_0213	1.579e-59	208.0	COG2216@1|root,COG2216@2|Bacteria,1MU7D@1224|Proteobacteria,2VH26@28216|Betaproteobacteria,3T30H@506|Alcaligenaceae	28216|Betaproteobacteria	P	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system	kdpB	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0008556,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0015672,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0031004,GO:0031224,GO:0031226,GO:0032991,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0071944,GO:0090533,GO:0090662,GO:0098533,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1902494,GO:1902495,GO:1904949,GO:1990351	3.6.3.12	ko:K01547	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	3.A.3.7	-	-	E1-E2_ATPase,Hydrolase
HKD2_k127_221567_0	469378.Ccur_12330	2.807e-180	576.0	COG0535@1|root,COG0535@2|Bacteria,2GNSY@201174|Actinobacteria,4CUKZ@84998|Coriobacteriia	84998|Coriobacteriia	C	Iron-sulfur cluster-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM,SPASM
HKD2_k127_221567_1	471855.Shel_11640	2.382e-150	482.0	COG0113@1|root,COG0113@2|Bacteria,2GJJ0@201174|Actinobacteria,4CVAC@84998|Coriobacteriia	84998|Coriobacteriia	H	Belongs to the ALAD family	-	-	4.2.1.24	ko:K01698	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00036	RC00918,RC01781	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ALAD
HKD2_k127_221567_9	553184.ATORI0001_0607	4.849e-05	48.0	COG1313@1|root,COG1313@2|Bacteria,2HUFM@201174|Actinobacteria,4CUFC@84998|Coriobacteriia	84998|Coriobacteriia	C	Radical SAM domain protein	-	-	1.97.1.4	ko:K04070	-	-	-	-	ko00000,ko01000	-	-	-	Fer4_12,Fer4_14,Radical_SAM
HKD2_k127_221567_3	1173026.Glo7428_0430	7.374e-113	398.0	COG2202@1|root,COG5001@1|root,COG2202@2|Bacteria,COG5001@2|Bacteria,1G0SY@1117|Cyanobacteria	1117|Cyanobacteria	T	signal transduction protein containing a membrane domain an EAL and a GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GAF,GGDEF,PAS_3,PAS_9
HKD2_k127_221567_5	1121406.JAEX01000018_gene2832	5.587e-62	222.0	COG0007@1|root,COG1587@1|root,COG0007@2|Bacteria,COG1587@2|Bacteria,1MUI0@1224|Proteobacteria,42MCB@68525|delta/epsilon subdivisions,2WIRJ@28221|Deltaproteobacteria,2M9KC@213115|Desulfovibrionales	28221|Deltaproteobacteria	H	Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase	hemD	-	1.3.1.76,2.1.1.107,4.2.1.75,4.99.1.4	ko:K02302,ko:K02303,ko:K13542	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02864,R03165,R03194,R03947	RC00003,RC00871,RC01012,RC01034,RC01861	ko00000,ko00001,ko00002,ko01000	-	-	-	HEM4,TP_methylase
HKD2_k127_221567_4	1304885.AUEY01000013_gene3121	6.158e-96	326.0	COG0181@1|root,COG0181@2|Bacteria,1MU56@1224|Proteobacteria,42M84@68525|delta/epsilon subdivisions,2WJ5V@28221|Deltaproteobacteria,2MISN@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps	hemC	GO:0003674,GO:0003824,GO:0004418,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.61	ko:K01749	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00084	RC02317	ko00000,ko00001,ko00002,ko01000	-	-	-	Porphobil_deam,Porphobil_deamC
HKD2_k127_221567_2	1125863.JAFN01000001_gene1123	3.095e-127	433.0	COG0373@1|root,COG0373@2|Bacteria,1MU41@1224|Proteobacteria,42MUG@68525|delta/epsilon subdivisions,2WISB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)	hemA	-	1.2.1.70	ko:K02492	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R04109	RC00055,RC00149	ko00000,ko00001,ko00002,ko01000	-	-	-	GlutR_N,GlutR_dimer,Shikimate_DH
HKD2_k127_221567_6	1254432.SCE1572_27975	8.565e-55	207.0	COG0300@1|root,COG0300@2|Bacteria,1RGKZ@1224|Proteobacteria,43BQ7@68525|delta/epsilon subdivisions,2X7IJ@28221|Deltaproteobacteria,2Z3IA@29|Myxococcales	28221|Deltaproteobacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HKD2_k127_221567_7	643648.Slip_1429	4.673e-27	119.0	COG1648@1|root,COG1648@2|Bacteria,1VA2E@1239|Firmicutes,24N6M@186801|Clostridia,42K0D@68298|Syntrophomonadaceae	186801|Clostridia	H	Sirohaem synthase dimerisation region	cysG	-	1.3.1.76,4.99.1.4	ko:K02304	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02864,R03947	RC01012,RC01034	ko00000,ko00001,ko00002,ko01000	-	-	-	CysG_dimeriser,NAD_binding_7,Sirohm_synth_M
HKD2_k127_221567_8	40571.JOEA01000013_gene1172	4.127e-10	70.0	COG0755@1|root,COG0755@2|Bacteria,2GJR1@201174|Actinobacteria,4DXN9@85010|Pseudonocardiales	201174|Actinobacteria	O	Cytochrome c assembly protein	ccsB	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C_asm
HKD2_k127_2270203_20	717785.HYPMC_1707	4.127e-05	47.0	2DGHW@1|root,2ZW1T@2|Bacteria,1P867@1224|Proteobacteria,2UWAZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Evidence 5 No homology to any previously reported sequences	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2270203_15	926569.ANT_10990	1.094e-24	110.0	COG0664@1|root,COG0664@2|Bacteria,2G92E@200795|Chloroflexi	200795|Chloroflexi	T	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
HKD2_k127_2270203_18	1229276.DI53_3514	2.355e-10	71.0	COG5061@1|root,COG5061@2|Bacteria	2|Bacteria	OU	protein folding in endoplasmic reticulum	satE	-	-	ko:K19134	-	-	-	-	ko00000,ko02048	-	-	-	DUF3307
HKD2_k127_2270203_17	502025.Hoch_3346	4.961e-16	92.0	COG1262@1|root,COG2114@1|root,COG5635@1|root,COG1262@2|Bacteria,COG2114@2|Bacteria,COG5635@2|Bacteria,1R66C@1224|Proteobacteria	1224|Proteobacteria	T	NACHT domain	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase,NACHT
HKD2_k127_2270203_8	755731.Clo1100_3900	1.014e-62	223.0	COG1595@1|root,COG1595@2|Bacteria,1TP55@1239|Firmicutes,249VX@186801|Clostridia,36ETQ@31979|Clostridiaceae	186801|Clostridia	K	Belongs to the sigma-70 factor family	sigH	-	-	ko:K03091	-	-	-	-	ko00000,ko03021	-	-	-	GerE,Sigma70_r2,Sigma70_r4_2
HKD2_k127_2270203_9	700015.Corgl_1377	1.503e-59	233.0	COG0566@1|root,COG0566@2|Bacteria,2GJMR@201174|Actinobacteria,4CV66@84998|Coriobacteriia	84998|Coriobacteriia	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family	-	-	2.1.1.185	ko:K03218	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SpoU_methylase,SpoU_sub_bind
HKD2_k127_2270203_2	868595.Desca_0187	1.419e-152	497.0	COG0215@1|root,COG0215@2|Bacteria,1TP9D@1239|Firmicutes,247KS@186801|Clostridia,2609V@186807|Peptococcaceae	186801|Clostridia	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	-	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e,tRNA-synt_1g
HKD2_k127_2270203_7	401526.TcarDRAFT_0124	9.234e-74	256.0	COG1045@1|root,COG1045@2|Bacteria,1TR42@1239|Firmicutes,4H2RG@909932|Negativicutes	909932|Negativicutes	E	serine O-acetyltransferase	cysE	-	2.3.1.30	ko:K00640	ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111	M00021	R00586	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,SATase_N
HKD2_k127_2270203_10	521095.Apar_1183	1.663e-59	211.0	COG0245@1|root,COG0245@2|Bacteria,2II8H@201174|Actinobacteria,4CW0D@84998|Coriobacteriia	84998|Coriobacteriia	H	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP)	ispF	-	4.6.1.12	ko:K01770	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05637	RC00002,RC01440	ko00000,ko00001,ko00002,ko01000	-	-	-	YgbB
HKD2_k127_2270203_13	1232436.CAPF01000067_gene1531	7.615e-52	200.0	COG1211@1|root,COG1211@2|Bacteria,2GNHP@201174|Actinobacteria,4CV1H@84998|Coriobacteriia	84998|Coriobacteriia	I	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP)	ispD	-	2.7.7.60	ko:K00991	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	IspD
HKD2_k127_2270203_6	887929.HMP0721_1126	2.87e-74	263.0	COG4956@1|root,COG4956@2|Bacteria,1TP0P@1239|Firmicutes,248F4@186801|Clostridia,25VAI@186806|Eubacteriaceae	186801|Clostridia	S	Large family of predicted nucleotide-binding domains	yacL	-	-	-	-	-	-	-	-	-	-	-	PIN,PIN_4,TRAM
HKD2_k127_2270203_5	429009.Adeg_0397	2.796e-96	326.0	COG1623@1|root,COG1623@2|Bacteria,1TQD8@1239|Firmicutes,247J4@186801|Clostridia,42FW5@68295|Thermoanaerobacterales	186801|Clostridia	L	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation	disA	-	2.7.7.85	ko:K07067	-	-	-	-	ko00000,ko01000	-	-	-	DisA-linker,DisA_N,HHH,HHH_2
HKD2_k127_2270203_3	1232410.KI421412_gene157	2.79e-128	423.0	COG1066@1|root,COG1066@2|Bacteria,1MUJQ@1224|Proteobacteria,42MG8@68525|delta/epsilon subdivisions,2WJWP@28221|Deltaproteobacteria,43S0X@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function	radA	-	-	ko:K04485	-	-	-	-	ko00000,ko03400	-	-	-	AAA_25,ATPase,ChlI,Lon_C
HKD2_k127_2270203_0	1283283.ATXA01000006_gene1810	0.0	1138.0	COG0542@1|root,COG0542@2|Bacteria,2GJ77@201174|Actinobacteria,4ERE5@85013|Frankiales	201174|Actinobacteria	O	Clp domain protein	clpC	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006457,GO:0008150,GO:0009987,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030312,GO:0040007,GO:0042802,GO:0042803,GO:0044183,GO:0044424,GO:0044444,GO:0044464,GO:0046983,GO:0071944	-	ko:K03696	ko01100,map01100	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N,UVR
HKD2_k127_2270203_1	471855.Shel_19490	6.252e-188	600.0	COG1190@1|root,COG1190@2|Bacteria,2GKE0@201174|Actinobacteria,4CUAX@84998|Coriobacteriia	84998|Coriobacteriia	J	Belongs to the class-II aminoacyl-tRNA synthetase family	lysS	-	6.1.1.6	ko:K04567	ko00970,map00970	M00359,M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon,tRNA_bind
HKD2_k127_2270203_14	645991.Sgly_0226	4.58e-43	168.0	COG0782@1|root,COG0782@2|Bacteria,1V44S@1239|Firmicutes,24HP9@186801|Clostridia,261HN@186807|Peptococcaceae	186801|Clostridia	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides	greA	-	-	ko:K03624	-	-	-	-	ko00000,ko03021	-	-	-	GreA_GreB,GreA_GreB_N
HKD2_k127_2270203_19	1118060.CAGZ01000030_gene1234	1.718e-08	59.0	COG1826@1|root,COG1826@2|Bacteria,2HVCP@201174|Actinobacteria,4CWNP@84998|Coriobacteriia	84998|Coriobacteriia	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system	-	-	-	ko:K03116	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
HKD2_k127_2270203_12	266117.Rxyl_3182	9.216e-55	200.0	COG2344@1|root,COG2344@2|Bacteria,2GMV2@201174|Actinobacteria,4CPVR@84995|Rubrobacteria	84995|Rubrobacteria	K	Modulates transcription in response to changes in cellular NADH NAD( ) redox state	rex	-	-	ko:K01926	-	-	-	-	ko00000,ko03000	-	-	-	CoA_binding,DUF836,Put_DNA-bind_N
HKD2_k127_2270203_4	643648.Slip_0897	7.574e-110	368.0	COG0005@1|root,COG0005@2|Bacteria,1TQ37@1239|Firmicutes,247KQ@186801|Clostridia,42JJA@68298|Syntrophomonadaceae	186801|Clostridia	F	Purine nucleoside phosphorylase which is highly specific for 6-oxopurine nucleosides. Cleaves guanosine or inosine to respective bases and sugar-1-phosphate molecules. Involved in purine salvage	-	-	2.4.2.28	ko:K00772	ko00270,ko01100,map00270,map01100	M00034	R01402	RC00063,RC02819	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
HKD2_k127_2270203_11	485916.Dtox_1796	2.551e-55	206.0	COG3481@1|root,COG3481@2|Bacteria,1TPIU@1239|Firmicutes,248SS@186801|Clostridia,261MI@186807|Peptococcaceae	186801|Clostridia	S	PFAM HD domain	-	-	-	ko:K03698	-	-	-	-	ko00000,ko01000,ko03019	-	-	-	HD,tRNA_anti-codon
HKD2_k127_2270203_16	485913.Krac_6737	1.344e-16	88.0	2E3IJ@1|root,32YH0@2|Bacteria,2G7AM@200795|Chloroflexi	200795|Chloroflexi	S	Predicted membrane protein (DUF2085)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2085
HKD2_k127_2280367_9	1034345.CAEM01000022_gene10	2.565e-55	196.0	COG0440@1|root,COG0440@2|Bacteria,2GJCH@201174|Actinobacteria,4CUNX@84998|Coriobacteriia	84998|Coriobacteriia	E	ACT domain	ilvN	-	2.2.1.6	ko:K01653	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,ACT_5,ALS_ss_C
HKD2_k127_2280367_3	1262914.BN533_00421	1.723e-147	476.0	COG0059@1|root,COG0059@2|Bacteria,1TPI7@1239|Firmicutes,4H1XP@909932|Negativicutes	909932|Negativicutes	H	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate	ilvC	-	1.1.1.86	ko:K00053	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R03051,R04439,R04440,R05068,R05069,R05071	RC00726,RC00836,RC00837,RC01726	ko00000,ko00001,ko00002,ko01000	-	-	-	IlvC,IlvN
HKD2_k127_2280367_5	1231241.Mc24_04695	4.484e-122	402.0	COG0075@1|root,COG0075@2|Bacteria,2GCGI@200918|Thermotogae	200918|Thermotogae	E	PFAM aminotransferase class V	-	GO:0001505,GO:0003674,GO:0003824,GO:0004760,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0006082,GO:0006520,GO:0006544,GO:0006545,GO:0006807,GO:0008150,GO:0008152,GO:0008453,GO:0008483,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0017144,GO:0019265,GO:0019752,GO:0042133,GO:0042136,GO:0042579,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	-	-	-	-	-	-	-	-	-	-	Aminotran_5
HKD2_k127_2280367_2	1034345.CAEM01000022_gene8	9.295e-168	554.0	COG1052@1|root,COG1052@2|Bacteria,2I2RK@201174|Actinobacteria,4CUMA@84998|Coriobacteriia	84998|Coriobacteriia	E	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain	-	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C,ACT
HKD2_k127_2280367_0	1118060.CAGZ01000014_gene1526	4.273e-216	682.0	COG0119@1|root,COG0119@2|Bacteria,2GISX@201174|Actinobacteria,4CUG3@84998|Coriobacteriia	84998|Coriobacteriia	E	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)	leuA	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
HKD2_k127_2280367_1	502558.EGYY_22220	4.114e-211	662.0	COG0065@1|root,COG0065@2|Bacteria,2GKT7@201174|Actinobacteria,4CUFG@84998|Coriobacteriia	84998|Coriobacteriia	H	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuC	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
HKD2_k127_2280367_8	502558.EGYY_22210	4.899e-79	266.0	COG0066@1|root,COG0066@2|Bacteria,2GJ8Z@201174|Actinobacteria,4CVQ4@84998|Coriobacteriia	84998|Coriobacteriia	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuD	-	4.2.1.33,4.2.1.35	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R10170	RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase_C
HKD2_k127_2280367_4	498761.HM1_1518	2.14e-129	423.0	COG0473@1|root,COG0473@2|Bacteria,1TPEM@1239|Firmicutes,24A63@186801|Clostridia	186801|Clostridia	C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate	leuB	-	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
HKD2_k127_2280367_6	1384484.AEQU_1885	3.023e-118	391.0	COG0115@1|root,COG0115@2|Bacteria,2GKJ1@201174|Actinobacteria,4CV50@84998|Coriobacteriia	84998|Coriobacteriia	H	Branched-chain amino acid aminotransferase	ilvE	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
HKD2_k127_2280367_11	211114.JOEF01000023_gene5793	1.941e-26	117.0	COG1309@1|root,COG1309@2|Bacteria,2GQRD@201174|Actinobacteria,4E3KD@85010|Pseudonocardiales	201174|Actinobacteria	K	Tetracyclin repressor, C-terminal all-alpha domain	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C,TetR_N
HKD2_k127_2280367_12	383372.Rcas_2492	1.13e-22	104.0	COG4635@1|root,COG4635@2|Bacteria,2G739@200795|Chloroflexi,377J0@32061|Chloroflexia	32061|Chloroflexia	CH	Flavodoxin domain	-	-	1.3.5.3	ko:K00230	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R09489	RC00885	ko00000,ko00001,ko00002,ko01000	-	-	-	Flavodoxin_5
HKD2_k127_2280367_7	1385935.N836_01620	3.399e-99	330.0	COG0655@1|root,COG0655@2|Bacteria,1GB8R@1117|Cyanobacteria,1HDV7@1150|Oscillatoriales	1117|Cyanobacteria	S	Nadph-dependent fmn reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
HKD2_k127_2280367_10	1316936.K678_16685	1.396e-31	131.0	COG0642@1|root,COG2202@1|root,COG5002@1|root,COG2202@2|Bacteria,COG2205@2|Bacteria,COG5002@2|Bacteria,1NRP8@1224|Proteobacteria,2TXJ2@28211|Alphaproteobacteria,2JPEA@204441|Rhodospirillales	204441|Rhodospirillales	T	Histidine kinase	-	-	2.7.13.3	ko:K11527	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	GAF_2,HATPase_c,HisKA,Hpt,PAS_3,PAS_4,PAS_9,Response_reg,dCache_1
HKD2_k127_2526721_6	1034345.CAEM01000023_gene867	5.626e-57	202.0	COG1951@1|root,COG1951@2|Bacteria,2I7Z2@201174|Actinobacteria,4CUKE@84998|Coriobacteriia	84998|Coriobacteriia	C	Fumarate hydratase (Fumerase)	-	-	4.2.1.2	ko:K01677	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumerase
HKD2_k127_2526721_14	479437.Elen_1143	6.552e-06	54.0	COG1951@1|root,COG1951@2|Bacteria,2I7Z2@201174|Actinobacteria,4CUKE@84998|Coriobacteriia	84998|Coriobacteriia	C	Fumarate hydratase (Fumerase)	-	-	4.2.1.2	ko:K01677	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumerase
HKD2_k127_2526721_3	357808.RoseRS_0253	9.341e-94	316.0	COG0039@1|root,COG0039@2|Bacteria,2G61S@200795|Chloroflexi,374VR@32061|Chloroflexia	32061|Chloroflexia	C	Catalyzes the reversible oxidation of malate to oxaloacetate	mdh	-	1.1.1.37	ko:K00024	ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740	R00342,R07136	RC00031	ko00000,ko00001,ko00002,ko01000	-	-	-	Ldh_1_C,Ldh_1_N
HKD2_k127_2526721_0	742818.HMPREF9451_00220	2.989e-259	822.0	COG0550@1|root,COG0551@1|root,COG0550@2|Bacteria,COG0551@2|Bacteria,2GJU7@201174|Actinobacteria,4CU99@84998|Coriobacteriia	84998|Coriobacteriia	L	DNA topoisomerase	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,zf-C4_Topoisom
HKD2_k127_2526721_7	2423.NA23_0200355	9.204e-53	191.0	COG2316@1|root,COG2316@2|Bacteria,2GCT9@200918|Thermotogae	200918|Thermotogae	S	PFAM metal-dependent phosphohydrolase, HD sub domain	-	-	-	ko:K06951	-	-	-	-	ko00000	-	-	-	HD
HKD2_k127_2526721_4	742818.HMPREF9451_00090	5.082e-90	302.0	COG0378@1|root,COG0378@2|Bacteria,2HP34@201174|Actinobacteria,4CVE2@84998|Coriobacteriia	84998|Coriobacteriia	KO	Hydrogenase accessory protein HypB	-	-	-	ko:K04652	-	-	-	-	ko00000,ko03110	-	-	-	cobW
HKD2_k127_2526721_9	479437.Elen_2830	1.942e-35	140.0	COG0375@1|root,COG0375@2|Bacteria,2IMJK@201174|Actinobacteria,4CWCV@84998|Coriobacteriia	84998|Coriobacteriia	S	Probably plays a role in a hydrogenase nickel cofactor insertion step	hypA	-	-	ko:K04651	-	-	-	-	ko00000,ko03110	-	-	-	HypA
HKD2_k127_2526721_5	479437.Elen_2831	2.598e-71	248.0	COG0805@1|root,COG0805@2|Bacteria,2GJK8@201174|Actinobacteria,4CV6F@84998|Coriobacteriia	84998|Coriobacteriia	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides	tatC	-	-	ko:K03118	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	TatC
HKD2_k127_2526721_12	1118060.CAGZ01000030_gene1129	9.107e-08	60.0	COG1826@1|root,COG1826@2|Bacteria,2HV4G@201174|Actinobacteria,4CWA9@84998|Coriobacteriia	84998|Coriobacteriia	U	Twin arginine-targeting protein translocase, TatA E family	-	-	-	ko:K03117,ko:K03646	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02000,ko02044	2.A.64,2.C.1.2	-	-	MttA_Hcf106
HKD2_k127_2526721_10	996637.SGM_4246	3.68e-30	123.0	COG1366@1|root,COG1366@2|Bacteria,2IHQG@201174|Actinobacteria	201174|Actinobacteria	T	Belongs to the anti-sigma-factor antagonist family	rsbV	GO:0003674,GO:0005488,GO:0005515,GO:0042802	-	ko:K04749	-	-	-	-	ko00000,ko03021	-	-	-	STAS
HKD2_k127_2526721_13	1430440.MGMSRv2_4254	1.109e-06	56.0	COG1366@1|root,COG1366@2|Bacteria	2|Bacteria	T	antisigma factor binding	-	-	-	ko:K04749,ko:K17763,ko:K20978	ko02020,ko02025,map02020,map02025	-	-	-	ko00000,ko00001,ko03021	-	-	-	Protoglobin,STAS,STAS_2
HKD2_k127_2526721_15	1101195.Meth11DRAFT_0026	0.0003825	52.0	COG0457@1|root,COG3914@1|root,COG4421@1|root,COG0457@2|Bacteria,COG3914@2|Bacteria,COG4421@2|Bacteria,1MVMG@1224|Proteobacteria,2VH3M@28216|Betaproteobacteria,2KMDJ@206350|Nitrosomonadales	206350|Nitrosomonadales	O	Glycosyltransferase like family	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_5,Glyco_transf_41,Methyltransf_12,TPR_1,TPR_11,TPR_16,TPR_2,TPR_8
HKD2_k127_2526721_11	697281.Mahau_0937	3.086e-08	66.0	COG3086@1|root,COG3086@2|Bacteria,1VEYP@1239|Firmicutes,24R8Z@186801|Clostridia	186801|Clostridia	T	PFAM Positive regulator of sigma(E) RseC MucC	-	-	-	ko:K03803	-	-	-	-	ko00000,ko03021	-	-	-	RseC_MucC
HKD2_k127_2526721_2	502558.EGYY_26490	1.099e-129	429.0	COG0402@1|root,COG0402@2|Bacteria,2GM63@201174|Actinobacteria,4CV60@84998|Coriobacteriia	84998|Coriobacteriia	F	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
HKD2_k127_2526721_8	502558.EGYY_26510	7.512e-52	192.0	COG0500@1|root,COG2226@2|Bacteria,2GKFZ@201174|Actinobacteria,4CUXZ@84998|Coriobacteriia	84998|Coriobacteriia	H	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2)	menG	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Ubie_methyltran
HKD2_k127_2526721_1	635013.TherJR_0239	5.484e-147	482.0	COG1032@1|root,COG1032@2|Bacteria,1UZQC@1239|Firmicutes,24PDA@186801|Clostridia	186801|Clostridia	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
HKD2_k127_2579122_11	1384484.AEQU_1129	3.489e-57	224.0	COG0440@1|root,COG0440@2|Bacteria,2GJCH@201174|Actinobacteria,4CUNX@84998|Coriobacteriia	84998|Coriobacteriia	E	ACT domain	ilvN	-	2.2.1.6	ko:K01653	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,ACT_5,ALS_ss_C
HKD2_k127_2579122_1	479437.Elen_1877	1.579e-223	706.0	COG0028@1|root,COG0028@2|Bacteria,2GKU4@201174|Actinobacteria,4CUQ8@84998|Coriobacteriia	84998|Coriobacteriia	H	Thiamine pyrophosphate enzyme, central domain	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
HKD2_k127_2579122_0	1121430.JMLG01000011_gene345	1.345e-224	713.0	COG0129@1|root,COG0129@2|Bacteria,1TP1R@1239|Firmicutes,247UC@186801|Clostridia,260AW@186807|Peptococcaceae	186801|Clostridia	EG	Belongs to the IlvD Edd family	ilvD	-	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
HKD2_k127_2579122_12	1121106.JQKB01000012_gene4682	7.317e-35	148.0	COG0265@1|root,COG0823@1|root,COG2931@1|root,COG0265@2|Bacteria,COG0823@2|Bacteria,COG2931@2|Bacteria	2|Bacteria	Q	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	ko:K08372	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	HemolysinCabind,NACHT,PDZ_2,Trypsin_2,VCBS
HKD2_k127_2579122_13	1121106.JQKB01000012_gene4682	2.666e-30	134.0	COG0265@1|root,COG0823@1|root,COG2931@1|root,COG0265@2|Bacteria,COG0823@2|Bacteria,COG2931@2|Bacteria	2|Bacteria	Q	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	ko:K08372	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	HemolysinCabind,NACHT,PDZ_2,Trypsin_2,VCBS
HKD2_k127_2579122_8	196162.Noca_0483	2.035e-87	305.0	COG0123@1|root,COG0123@2|Bacteria,2GJUH@201174|Actinobacteria,4DN6Q@85009|Propionibacteriales	201174|Actinobacteria	BQ	Histone deacetylase domain	acuC	-	-	ko:K04768	-	-	-	-	ko00000	-	-	-	Hist_deacetyl
HKD2_k127_2579122_19	1211114.ALIP01000006_gene940	0.0001839	53.0	COG0823@1|root,COG3710@1|root,COG0823@2|Bacteria,COG3710@2|Bacteria,1PYUK@1224|Proteobacteria,1S0VV@1236|Gammaproteobacteria,1X5W9@135614|Xanthomonadales	135614|Xanthomonadales	KU	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Trans_reg_C
HKD2_k127_2579122_4	445975.COLSTE_00344	6.107e-152	490.0	COG0473@1|root,COG0473@2|Bacteria,2IAD3@201174|Actinobacteria,4CU7N@84998|Coriobacteriia	84998|Coriobacteriia	CE	Isocitrate/isopropylmalate dehydrogenase	-	-	1.1.1.41	ko:K00030	ko00020,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010	R00709	RC00114	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
HKD2_k127_2579122_6	477974.Daud_1728	5.017e-91	314.0	COG2202@1|root,COG2203@1|root,COG3437@1|root,COG3605@1|root,COG2202@2|Bacteria,COG2203@2|Bacteria,COG3437@2|Bacteria,COG3605@2|Bacteria,1UQJH@1239|Firmicutes,248UM@186801|Clostridia,261WQ@186807|Peptococcaceae	186801|Clostridia	T	HD domain	-	-	-	ko:K07814	-	-	-	-	ko00000,ko02022	-	-	-	GAF_2,HD,HD_5
HKD2_k127_2579122_7	215803.DB30_6887	2.066e-89	301.0	COG0789@1|root,COG0789@2|Bacteria,1REB7@1224|Proteobacteria,4347C@68525|delta/epsilon subdivisions,2X9UQ@28221|Deltaproteobacteria,2YWCK@29|Myxococcales	28221|Deltaproteobacteria	K	TipAS antibiotic-recognition domain	-	-	-	ko:K21744	-	-	-	-	ko00000,ko03000	-	-	-	MerR_1,TipAS
HKD2_k127_2579122_10	1336249.JADW01000001_gene2114	2.525e-63	227.0	COG0726@1|root,COG0726@2|Bacteria,1PJQG@1224|Proteobacteria,2TUBN@28211|Alphaproteobacteria,4BM9P@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	Polysaccharide deacetylase	-	-	3.5.1.104	ko:K22278	-	-	-	-	ko00000,ko01000	-	-	-	Polysacc_deac_1
HKD2_k127_2579122_9	429009.Adeg_1101	2.756e-70	241.0	COG0066@1|root,COG0066@2|Bacteria,1V1I6@1239|Firmicutes,24F1M@186801|Clostridia,42JF3@68295|Thermoanaerobacterales	186801|Clostridia	E	Aconitase C-terminal domain	-	-	4.2.1.33,4.2.1.35	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R10170	RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase_C
HKD2_k127_2579122_2	643648.Slip_0509	5.724e-181	597.0	COG0065@1|root,COG0065@2|Bacteria,1TPE5@1239|Firmicutes,2484F@186801|Clostridia,42KEK@68298|Syntrophomonadaceae	186801|Clostridia	H	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	-	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
HKD2_k127_2579122_3	935948.KE386495_gene2056	1.249e-163	525.0	COG0119@1|root,COG0119@2|Bacteria,1TP4Y@1239|Firmicutes,2495J@186801|Clostridia,42F5P@68295|Thermoanaerobacterales	186801|Clostridia	H	PFAM Pyruvate carboxyltransferase	nifV	-	2.3.3.14	ko:K02594	ko00620,map00620	-	R00271	RC00004,RC00067,RC02754	ko00000,ko00001,ko01000	-	-	-	HMGL-like
HKD2_k127_2579122_18	1283299.AUKG01000004_gene1153	3.688e-06	59.0	COG4726@1|root,COG4726@2|Bacteria,2ID24@201174|Actinobacteria	201174|Actinobacteria	NU	pilus assembly protein PilW	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2579122_17	1121428.DESHY_60063___1	9.576e-07	61.0	2DGJ9@1|root,2ZW7I@2|Bacteria,1W5TE@1239|Firmicutes,256WF@186801|Clostridia	186801|Clostridia	S	Pfam:N_methyl_2	-	-	-	-	-	-	-	-	-	-	-	-	N_methyl
HKD2_k127_2579122_16	218284.CCDN010000001_gene445	2.454e-08	66.0	COG4932@1|root,COG4932@2|Bacteria,1TQBI@1239|Firmicutes,4HBAT@91061|Bacilli,1ZD6Z@1386|Bacillus	91061|Bacilli	M	cell wall anchor domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Cna_B,Collagen_bind,Gram_pos_anchor,MucBP
HKD2_k127_2579122_14	511051.CSE_09390	5.291e-17	85.0	2C539@1|root,33HA4@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2579122_15	1348338.ADILRU_1125	1.66e-14	88.0	COG0791@1|root,COG2247@1|root,COG0791@2|Bacteria,COG2247@2|Bacteria,2IK12@201174|Actinobacteria	201174|Actinobacteria	M	cell wall binding repeat	-	-	-	-	-	-	-	-	-	-	-	-	CW_binding_2
HKD2_k127_2579122_5	13035.Dacsa_2785	7.737e-148	484.0	COG0064@1|root,COG0064@2|Bacteria,1G0H0@1117|Cyanobacteria	1117|Cyanobacteria	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatB	GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	GatB_N,GatB_Yqey
HKD2_k127_2579122_20	1121422.AUMW01000008_gene476	0.0009014	46.0	COG5001@1|root,COG5001@2|Bacteria	2|Bacteria	T	cyclic-guanylate-specific phosphodiesterase activity	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS,PAS_9,Response_reg
HKD2_k127_2679593_8	1380390.JIAT01000010_gene3578	3.749e-05	48.0	COG1573@1|root,COG1573@2|Bacteria,2GMPT@201174|Actinobacteria,4CSJB@84995|Rubrobacteria	84995|Rubrobacteria	L	Uracil DNA glycosylase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	UDG
HKD2_k127_2679593_7	1125712.HMPREF1316_0734	2.651e-34	139.0	COG0802@1|root,COG0802@2|Bacteria,2IKV2@201174|Actinobacteria,4CVWX@84998|Coriobacteriia	84998|Coriobacteriia	S	Hydrolase, P-loop family	-	-	-	ko:K06925	-	-	-	-	ko00000,ko03016	-	-	-	TsaE
HKD2_k127_2679593_5	502558.EGYY_26550	1.152e-41	171.0	COG0454@1|root,COG0533@1|root,COG1214@1|root,COG0456@2|Bacteria,COG0533@2|Bacteria,COG1214@2|Bacteria,2GJ98@201174|Actinobacteria,4CUKY@84998|Coriobacteriia	84998|Coriobacteriia	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction	tsaD	-	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Acetyltransf_1,Peptidase_M22
HKD2_k127_2679593_2	1504822.CCNO01000014_gene1631	1.702e-143	477.0	COG0454@1|root,COG0533@1|root,COG1214@1|root,COG0456@2|Bacteria,COG0533@2|Bacteria,COG1214@2|Bacteria,2NNXP@2323|unclassified Bacteria	2|Bacteria	O	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction	tsaD	GO:0000287,GO:0000408,GO:0002949,GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0004596,GO:0005488,GO:0005506,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006464,GO:0006473,GO:0006474,GO:0006508,GO:0006725,GO:0006807,GO:0008033,GO:0008080,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0008999,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0016787,GO:0017189,GO:0018193,GO:0018194,GO:0019538,GO:0030312,GO:0031365,GO:0032991,GO:0034212,GO:0034470,GO:0034641,GO:0034660,GO:0036211,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0051604,GO:0070011,GO:0070525,GO:0071704,GO:0071944,GO:0090304,GO:0140030,GO:0140032,GO:0140096,GO:1901360,GO:1901564	2.3.1.128,2.3.1.234	ko:K01409,ko:K03070,ko:K03789,ko:K14742	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	R10648	RC00070,RC00416	ko00000,ko00001,ko00002,ko01000,ko02044,ko03009,ko03016	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	Acetyltransf_1,Peptidase_M22
HKD2_k127_2679593_6	742722.HMPREF9463_01016	7.597e-35	137.0	COG0234@1|root,COG0234@2|Bacteria,2IKTH@201174|Actinobacteria,4CW90@84998|Coriobacteriia	84998|Coriobacteriia	O	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter	groS	-	-	ko:K04078	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Cpn10
HKD2_k127_2679593_0	401526.TcarDRAFT_0384	2.466e-233	734.0	COG0459@1|root,COG0459@2|Bacteria,1TP1T@1239|Firmicutes,4H29X@909932|Negativicutes	909932|Negativicutes	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	-	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
HKD2_k127_2679593_4	1121468.AUBR01000005_gene97	1.275e-45	180.0	COG0438@1|root,COG0438@2|Bacteria,1TPTA@1239|Firmicutes,24ANI@186801|Clostridia,42FW0@68295|Thermoanaerobacterales	186801|Clostridia	M	glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
HKD2_k127_2679593_1	661087.HMPREF1008_00305	1.598e-146	473.0	COG0012@1|root,COG0012@2|Bacteria,2GIXI@201174|Actinobacteria,4CUCP@84998|Coriobacteriia	84998|Coriobacteriia	J	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner	ychF	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,YchF-GTPase_C
HKD2_k127_2679593_3	525909.Afer_0459	1.28e-105	352.0	COG0516@1|root,COG0516@2|Bacteria,2GKVS@201174|Actinobacteria,4CNDM@84992|Acidimicrobiia	84992|Acidimicrobiia	F	IMP dehydrogenase / GMP reductase domain	-	-	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,IMPDH
HKD2_k127_2824665_0	502558.EGYY_14680	3.647e-204	645.0	COG0458@1|root,COG0458@2|Bacteria,2GK5N@201174|Actinobacteria,4CUHZ@84998|Coriobacteriia	84998|Coriobacteriia	F	Belongs to the CarB family	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
HKD2_k127_2824665_3	1034345.CAEM01000019_gene1717	1.465e-59	232.0	COG0543@1|root,COG0543@2|Bacteria,2HQ24@201174|Actinobacteria,4CV6M@84998|Coriobacteriia	84998|Coriobacteriia	C	Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( )	pyrK	-	-	ko:K02823	ko00240,ko01100,map00240,map01100	-	-	-	ko00000,ko00001	-	-	-	DHODB_Fe-S_bind,FAD_binding_6,NAD_binding_1
HKD2_k127_2824665_1	469378.Ccur_07830	1.149e-122	400.0	COG0167@1|root,COG0167@2|Bacteria,2GKC6@201174|Actinobacteria,4CUEZ@84998|Coriobacteriia	84998|Coriobacteriia	F	Catalyzes the conversion of dihydroorotate to orotate	pyrD	-	1.3.1.14	ko:K17828	ko00240,ko01100,map00240,map01100	M00051	R01869	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
HKD2_k127_2824665_2	1118060.CAGZ01000024_gene529	1.477e-71	249.0	COG0284@1|root,COG0284@2|Bacteria,2IPX2@201174|Actinobacteria,4CV9H@84998|Coriobacteriia	84998|Coriobacteriia	F	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)	pyrF	-	4.1.1.23	ko:K01591	ko00240,ko01100,map00240,map01100	M00051	R00965	RC00409	ko00000,ko00001,ko00002,ko01000	-	-	-	OMPdecase
HKD2_k127_2824665_4	1089553.Tph_c14410	1.161e-50	187.0	COG0461@1|root,COG0461@2|Bacteria,1V1BZ@1239|Firmicutes,25CGM@186801|Clostridia,42FJS@68295|Thermoanaerobacterales	186801|Clostridia	F	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)	pyrE	-	2.4.2.10	ko:K00762	ko00240,ko01100,map00240,map01100	M00051	R01870	RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran
HKD2_k127_2824665_5	471855.Shel_11900	5.965e-29	124.0	COG0099@1|root,COG0099@2|Bacteria,2IKPU@201174|Actinobacteria,4CW7U@84998|Coriobacteriia	84998|Coriobacteriia	J	integration host factor	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2824665_6	445975.COLSTE_01834	5.334e-28	115.0	COG0194@1|root,COG0194@2|Bacteria,2GK2M@201174|Actinobacteria,4CVKY@84998|Coriobacteriia	84998|Coriobacteriia	F	Essential for recycling GMP and indirectly, cGMP	gmk	-	2.7.4.8	ko:K00942	ko00230,ko01100,map00230,map01100	M00050	R00332,R02090	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_kin
HKD2_k127_2834980_0	671143.DAMO_1746	2.078e-41	169.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	rgpF	-	-	ko:K20444	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.1.3	GT2,GT4	-	Glyco_trans_1_2,Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1,Glycos_transf_2,RgpF
HKD2_k127_2967265_3	1094980.Mpsy_0336	1.005e-127	414.0	COG0040@1|root,arCOG02208@2157|Archaea,2Y2ZH@28890|Euryarchaeota,2NA8F@224756|Methanomicrobia	224756|Methanomicrobia	E	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity	-	-	2.4.2.17	ko:K00765	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002,ko01000	-	-	-	HisG,HisG_C
HKD2_k127_2967265_10	525368.HMPREF0591_3856	3.734e-11	74.0	COG3794@1|root,COG3794@2|Bacteria,2IQAI@201174|Actinobacteria,23AQX@1762|Mycobacteriaceae	201174|Actinobacteria	C	Copper binding proteins, plastocyanin/azurin family	-	-	-	-	-	-	-	-	-	-	-	-	Copper-bind,Cupredoxin_1
HKD2_k127_2967265_9	1086011.HJ01_00036	3.706e-31	130.0	COG4420@1|root,COG4420@2|Bacteria,4NH74@976|Bacteroidetes,1HYXZ@117743|Flavobacteriia,2NSRC@237|Flavobacterium	976|Bacteroidetes	S	Protein of unknown function (DUF1003)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1003
HKD2_k127_2967265_4	1035308.AQYY01000001_gene1905	2.108e-106	353.0	COG1136@1|root,COG1136@2|Bacteria,1TQC9@1239|Firmicutes,248Z6@186801|Clostridia,260NV@186807|Peptococcaceae	186801|Clostridia	V	ABC-type antimicrobial peptide transport system, ATPase component	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD2_k127_2967265_0	1035308.AQYY01000001_gene1906	9.529e-261	837.0	COG0577@1|root,COG4591@1|root,COG0577@2|Bacteria,COG4591@2|Bacteria,1TRE5@1239|Firmicutes,25GUR@186801|Clostridia,265C6@186807|Peptococcaceae	186801|Clostridia	MV	ABC-type transport system, involved in lipoprotein release, permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HKD2_k127_2967265_2	477641.MODMU_3515	1.714e-133	441.0	COG1915@1|root,COG1915@2|Bacteria,2GMEZ@201174|Actinobacteria,4EUTP@85013|Frankiales	201174|Actinobacteria	S	PFAM LOR SDH bifunctional	-	-	-	-	-	-	-	-	-	-	-	-	Saccharop_dh_N
HKD2_k127_2967265_7	690850.Desaf_0275	5.31e-50	183.0	COG0225@1|root,COG0225@2|Bacteria,1N2DQ@1224|Proteobacteria,42UC3@68525|delta/epsilon subdivisions,2WQBZ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	msrA	-	1.8.4.11	ko:K07304	-	-	-	-	ko00000,ko01000	-	-	-	PMSR
HKD2_k127_2967265_8	326424.FRAAL3773	1.618e-44	175.0	COG0229@1|root,COG0229@2|Bacteria,2IHV0@201174|Actinobacteria,4ESRX@85013|Frankiales	201174|Actinobacteria	O	PFAM Methionine sulfoxide reductase B	msrB	-	1.8.4.12	ko:K07305	-	-	-	-	ko00000,ko01000	-	-	-	SelR
HKD2_k127_2967265_6	926569.ANT_24880	7.001e-68	248.0	COG1028@1|root,COG1028@2|Bacteria,2G8EM@200795|Chloroflexi	200795|Chloroflexi	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HKD2_k127_2967265_5	747365.Thena_0451	1.381e-82	278.0	COG1592@1|root,COG1592@2|Bacteria,1V1FF@1239|Firmicutes,248V2@186801|Clostridia,42GAI@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM Rubrerythrin	rbr	GO:0003674,GO:0003824,GO:0004601,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009636,GO:0009987,GO:0016209,GO:0016491,GO:0016684,GO:0016692,GO:0022900,GO:0042221,GO:0044237,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
HKD2_k127_2967265_1	649764.HMPREF0762_01188	3.844e-168	550.0	COG1217@1|root,COG1217@2|Bacteria,2GJUJ@201174|Actinobacteria,4CUBE@84998|Coriobacteriia	84998|Coriobacteriia	T	GTP-binding protein TypA	typA	-	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2
HKD2_k127_3138750_8	742722.HMPREF9463_01649	2.149e-05	58.0	COG1674@1|root,COG1674@2|Bacteria,2GK3T@201174|Actinobacteria,4CU9F@84998|Coriobacteriia	84998|Coriobacteriia	D	FtsK SpoIIIE family	-	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
HKD2_k127_3138750_6	644282.Deba_2699	2.024e-42	165.0	COG1968@1|root,COG1968@2|Bacteria,1MX02@1224|Proteobacteria,42N67@68525|delta/epsilon subdivisions,2WPKC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin	uppP	-	3.6.1.27	ko:K06153	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	BacA
HKD2_k127_3138750_0	445975.COLSTE_01542	9.775e-207	658.0	COG0595@1|root,COG0595@2|Bacteria,2GIW7@201174|Actinobacteria,4CUDR@84998|Coriobacteriia	84998|Coriobacteriia	J	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay	rnj	-	-	ko:K12574	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	Lactamase_B,Lactamase_B_2,RMMBL
HKD2_k127_3138750_2	479437.Elen_1626	1.444e-107	358.0	COG0329@1|root,COG0329@2|Bacteria,2GJ34@201174|Actinobacteria,4CV9Z@84998|Coriobacteriia	84998|Coriobacteriia	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	dapA	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
HKD2_k127_3138750_5	338963.Pcar_2753	4.602e-61	226.0	COG3437@1|root,COG3437@2|Bacteria,1MUB8@1224|Proteobacteria,42T7G@68525|delta/epsilon subdivisions,2X75V@28221|Deltaproteobacteria,43UV8@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	HD_5
HKD2_k127_3138750_3	555079.Toce_0625	2.377e-92	335.0	COG0527@1|root,COG0527@2|Bacteria,1TPQJ@1239|Firmicutes,24811@186801|Clostridia,42F4C@68295|Thermoanaerobacterales	186801|Clostridia	E	Belongs to the aspartokinase family	dapG	-	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT_7
HKD2_k127_3138750_4	555088.DealDRAFT_1545	3.395e-75	261.0	COG0289@1|root,COG0289@2|Bacteria,1TR9D@1239|Firmicutes,248FY@186801|Clostridia,42JTN@68298|Syntrophomonadaceae	186801|Clostridia	H	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate	dapB	-	1.17.1.8	ko:K00215	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R04198,R04199	RC00478	ko00000,ko00001,ko00002,ko01000	-	-	-	DapB_C,DapB_N
HKD2_k127_3138750_1	696281.Desru_1911	3.155e-108	369.0	COG0612@1|root,COG0612@2|Bacteria,1TP5I@1239|Firmicutes,248HT@186801|Clostridia,260B8@186807|Peptococcaceae	186801|Clostridia	S	Belongs to the peptidase M16 family	ymxG	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
HKD2_k127_3138750_7	1125712.HMPREF1316_1322	8.904e-22	97.0	COG1185@1|root,COG1185@2|Bacteria,2GIT2@201174|Actinobacteria,4CUVK@84998|Coriobacteriia	84998|Coriobacteriia	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	-	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
HKD2_k127_3175879_5	502558.EGYY_19780	1.171e-124	410.0	COG0653@1|root,COG0653@2|Bacteria,2GIRT@201174|Actinobacteria,4CV09@84998|Coriobacteriia	84998|Coriobacteriia	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	-	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
HKD2_k127_3175879_30	1173264.KI913949_gene4023	5.791e-31	139.0	COG3657@1|root,COG3657@2|Bacteria,1G6YT@1117|Cyanobacteria,1HCJV@1150|Oscillatoriales	1117|Cyanobacteria	S	Phage derived protein Gp49-like (DUF891)	-	-	-	-	-	-	-	-	-	-	-	-	Gp49
HKD2_k127_3175879_27	1162668.LFE_0136	1.072e-35	140.0	COG3636@1|root,COG3636@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3175879_21	864702.OsccyDRAFT_2779	1.754e-48	184.0	COG0454@1|root,COG0456@2|Bacteria,1G5EH@1117|Cyanobacteria	1117|Cyanobacteria	K	PFAM Acetyltransferase (GNAT) family	-	-	2.3.1.57	ko:K00657	ko00330,ko01100,ko04216,map00330,map01100,map04216	M00135	R01154	RC00004,RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetyltransf_1
HKD2_k127_3175879_2	502558.EGYY_19770	2.022e-136	451.0	COG1186@1|root,COG1186@2|Bacteria,2GJ0F@201174|Actinobacteria,4CUA5@84998|Coriobacteriia	84998|Coriobacteriia	J	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA	prfB	-	-	ko:K02836	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
HKD2_k127_3175879_23	1120985.AUMI01000004_gene1354	2.953e-47	190.0	COG1387@1|root,COG1387@2|Bacteria,1TQ33@1239|Firmicutes,4H1V2@909932|Negativicutes	909932|Negativicutes	E	PHP domain protein	-	-	-	ko:K04477	-	-	-	-	ko00000	-	-	-	PHP
HKD2_k127_3175879_13	1121422.AUMW01000019_gene1808	1.383e-73	258.0	COG1284@1|root,COG1284@2|Bacteria,1TR9J@1239|Firmicutes,25CBM@186801|Clostridia,260G1@186807|Peptococcaceae	186801|Clostridia	S	protein conserved in bacteria (DUF2179)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2179,YitT_membrane
HKD2_k127_3175879_10	479437.Elen_1998	2.701e-89	323.0	COG3959@1|root,COG3959@2|Bacteria,2GJ6M@201174|Actinobacteria,4CU8W@84998|Coriobacteriia	84998|Coriobacteriia	G	Transketolase, thiamine diphosphate binding domain	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_N
HKD2_k127_3175879_7	742818.HMPREF9451_01083	1.614e-113	380.0	COG3958@1|root,COG3958@2|Bacteria,2I8VM@201174|Actinobacteria,4CUD8@84998|Coriobacteriia	84998|Coriobacteriia	G	Transketolase, pyridine binding domain protein	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
HKD2_k127_3175879_8	502558.EGYY_19740	8.082e-106	355.0	COG2884@1|root,COG2884@2|Bacteria,2GJE1@201174|Actinobacteria,4CUBJ@84998|Coriobacteriia	84998|Coriobacteriia	D	cell division ATP-binding protein FtsE	ftsE	-	-	ko:K09812	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	ABC_tran
HKD2_k127_3175879_15	521095.Apar_1278	1.926e-64	231.0	COG2177@1|root,COG2177@2|Bacteria,2GJMA@201174|Actinobacteria,4CU8U@84998|Coriobacteriia	84998|Coriobacteriia	D	Part of the ABC transporter FtsEX involved in cellular division	-	-	-	ko:K09811	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	FtsX
HKD2_k127_3175879_12	246194.CHY_0170	5.421e-86	298.0	COG0793@1|root,COG0793@2|Bacteria,1TPBI@1239|Firmicutes,248HZ@186801|Clostridia,42EZ3@68295|Thermoanaerobacterales	186801|Clostridia	M	Belongs to the peptidase S41A family	ctpA	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_S41
HKD2_k127_3175879_26	635013.TherJR_0120	1.312e-36	154.0	COG0484@1|root,COG0484@2|Bacteria	2|Bacteria	O	heat shock protein binding	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_c3_2,Cytochrome_C554,Cytochrome_C7,Paired_CXXCH_1
HKD2_k127_3175879_40	1173028.ANKO01000083_gene906	1.856e-13	85.0	2AY0A@1|root,31Q1V@2|Bacteria,1G5XA@1117|Cyanobacteria,1HB3B@1150|Oscillatoriales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3175879_1	867903.ThesuDRAFT_00619	4.314e-164	549.0	COG0557@1|root,COG0557@2|Bacteria,1TQ1G@1239|Firmicutes,247ZS@186801|Clostridia,3WCE2@538999|Clostridiales incertae sedis	186801|Clostridia	K	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs	rnr	-	-	ko:K12573	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	OB_RNB,RNB,S1
HKD2_k127_3175879_4	1384484.AEQU_1351	7.735e-133	432.0	COG1363@1|root,COG1363@2|Bacteria,2ID5X@201174|Actinobacteria,4CUPJ@84998|Coriobacteriia	84998|Coriobacteriia	G	M42 glutamyl aminopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M42
HKD2_k127_3175879_28	398512.JQKC01000005_gene5620	5.725e-35	152.0	COG4908@1|root,COG4908@2|Bacteria,1V0U5@1239|Firmicutes,25D3E@186801|Clostridia,3WK8S@541000|Ruminococcaceae	186801|Clostridia	S	Condensation domain	-	-	-	-	-	-	-	-	-	-	-	-	Condensation
HKD2_k127_3175879_19	316067.Geob_2042	6.53e-51	194.0	COG2267@1|root,COG2267@2|Bacteria,1PSR9@1224|Proteobacteria,42Z3Y@68525|delta/epsilon subdivisions,2WU6M@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
HKD2_k127_3175879_22	502558.EGYY_19120	2.828e-48	191.0	COG0691@1|root,COG0691@2|Bacteria,2GJX1@201174|Actinobacteria,4CVMU@84998|Coriobacteriia	84998|Coriobacteriia	J	the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA	smpB	-	-	ko:K03664	-	-	-	-	ko00000	-	-	-	SmpB
HKD2_k127_3175879_36	1307761.L21SP2_2771	1.71e-16	83.0	COG1695@1|root,COG1695@2|Bacteria,2J937@203691|Spirochaetes	203691|Spirochaetes	K	Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	PadR
HKD2_k127_3175879_33	1437425.CSEC_0393	1.96e-25	110.0	COG1186@1|root,COG1186@2|Bacteria,2JH72@204428|Chlamydiae	204428|Chlamydiae	J	RF-1 domain	-	-	-	-	-	-	-	-	-	-	-	-	RF-1
HKD2_k127_3175879_14	1197719.A464_2482	4.38e-72	250.0	COG0586@1|root,COG0586@2|Bacteria,1MX4M@1224|Proteobacteria,1RPB1@1236|Gammaproteobacteria,3ZJHQ@590|Salmonella	1236|Gammaproteobacteria	S	SNARE associated Golgi protein	dedA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03975	-	-	-	-	ko00000	-	-	-	SNARE_assoc
HKD2_k127_3175879_6	756067.MicvaDRAFT_2720	1.102e-113	387.0	COG1520@1|root,COG1520@2|Bacteria,1G3FV@1117|Cyanobacteria,1H71Z@1150|Oscillatoriales	1117|Cyanobacteria	S	beta-propeller repeat	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2
HKD2_k127_3175879_29	635013.TherJR_0120	6.562e-33	141.0	COG0484@1|root,COG0484@2|Bacteria	2|Bacteria	O	heat shock protein binding	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_c3_2,Cytochrome_C554,Cytochrome_C7,Paired_CXXCH_1
HKD2_k127_3175879_18	1227739.Hsw_0287	1.672e-52	208.0	COG2374@1|root,COG5184@1|root,COG2374@2|Bacteria,COG5184@2|Bacteria,4NIP4@976|Bacteroidetes,47T9H@768503|Cytophagia	976|Bacteroidetes	DZ	Regulator of chromosome condensation (RCC1) repeat	-	-	-	-	-	-	-	-	-	-	-	-	LRR_5,RCC1
HKD2_k127_3175879_9	944479.JQLX01000013_gene1442	5.595e-98	333.0	COG2203@1|root,COG2206@1|root,COG2203@2|Bacteria,COG2206@2|Bacteria,1RAQS@1224|Proteobacteria,42MEJ@68525|delta/epsilon subdivisions,2X71A@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	metal-dependent phosphohydrolase HD region	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,GAF_3,HAMP,HD,HD_5
HKD2_k127_3175879_11	1123508.JH636439_gene722	4.932e-88	298.0	COG1432@1|root,COG1432@2|Bacteria,2IY4C@203682|Planctomycetes	203682|Planctomycetes	S	OST-HTH/LOTUS domain	-	-	-	-	-	-	-	-	-	-	-	-	NYN,OST-HTH
HKD2_k127_3175879_20	469378.Ccur_06040	4.479e-49	180.0	COG0652@1|root,COG0652@2|Bacteria,2HUQ0@201174|Actinobacteria,4CVCH@84998|Coriobacteriia	84998|Coriobacteriia	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	-	-	5.2.1.8	ko:K03768	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Pro_isomerase
HKD2_k127_3175879_35	1379698.RBG1_1C00001G1780	2.438e-19	90.0	COG0826@1|root,COG0826@2|Bacteria,2NS1M@2323|unclassified Bacteria	2|Bacteria	O	peptidase U32	yegQ	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K08303	ko05120,map05120	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_U32,Peptidase_U32_C
HKD2_k127_3175879_39	224325.AF_0166	5.592e-14	73.0	COG1141@1|root,arCOG00349@2157|Archaea,2Y1VB@28890|Euryarchaeota,246J7@183980|Archaeoglobi	183980|Archaeoglobi	C	4Fe-4S single cluster domain of Ferredoxin I	-	-	-	ko:K05337	-	-	-	-	ko00000	-	-	-	Fer4_13
HKD2_k127_3175879_25	582515.KR51_00032820	4.831e-40	158.0	COG1451@1|root,COG1451@2|Bacteria,1G6GG@1117|Cyanobacteria	1117|Cyanobacteria	S	Metal-dependent hydrolase	-	-	-	ko:K07043	-	-	-	-	ko00000	-	-	-	DUF45
HKD2_k127_3175879_0	926550.CLDAP_21080	9.39e-291	927.0	COG0474@1|root,COG0474@2|Bacteria,2G60Z@200795|Chloroflexi	200795|Chloroflexi	P	Cation transporting ATPase, C-terminus	-	-	3.6.3.2	ko:K01531	-	-	-	-	ko00000,ko01000	3.A.3.4	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
HKD2_k127_3175879_38	1242864.D187_010060	5.817e-15	84.0	COG0484@1|root,COG0484@2|Bacteria	2|Bacteria	O	heat shock protein binding	-	-	-	ko:K05516	-	-	-	-	ko00000,ko03036,ko03110	-	-	-	DnaJ,DnaJ_C
HKD2_k127_3175879_16	1128421.JAGA01000002_gene1450	4.131e-61	231.0	COG0457@1|root,COG1352@1|root,COG0457@2|Bacteria,COG1352@2|Bacteria,2NR62@2323|unclassified Bacteria	2|Bacteria	NT	Methyltransferase, chemotaxis proteins	frzF	-	2.1.1.80	ko:K00575	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko01000,ko02035	-	-	-	CheR,CheR_N,TPR_16,TPR_19,TPR_8
HKD2_k127_3175879_31	575540.Isop_3677	3.286e-30	124.0	COG0745@1|root,COG0745@2|Bacteria,2J342@203682|Planctomycetes	203682|Planctomycetes	T	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	-	-	-	ko:K02658	ko02020,ko02025,map02020,map02025	M00507	-	-	ko00000,ko00001,ko00002,ko02022,ko02035,ko02044	-	-	-	Response_reg
HKD2_k127_3175879_42	926554.KI912633_gene3696	1.528e-05	57.0	COG2804@1|root,COG2804@2|Bacteria,1WIW9@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	NU	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB	pilF	-	-	ko:K02652	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE,T2SSE_N
HKD2_k127_3175879_24	584708.Apau_1054	3.365e-46	183.0	COG2804@1|root,COG2804@2|Bacteria,3T9ZP@508458|Synergistetes	508458|Synergistetes	NU	Type II/IV secretion system protein	-	-	-	-	-	-	-	-	-	-	-	-	T2SSE
HKD2_k127_3175879_34	555779.Dthio_PD3146	1.208e-19	97.0	COG0835@1|root,COG0835@2|Bacteria,1RG4A@1224|Proteobacteria,43AIK@68525|delta/epsilon subdivisions,2X5YT@28221|Deltaproteobacteria,2MGWV@213115|Desulfovibrionales	28221|Deltaproteobacteria	NT	Two component signalling adaptor domain	cheW64H-1	-	-	ko:K03408	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheW
HKD2_k127_3175879_37	439292.Bsel_1766	3.167e-16	90.0	COG0835@1|root,COG0835@2|Bacteria,1V4HH@1239|Firmicutes,4HHB5@91061|Bacilli,26NXR@186821|Sporolactobacillaceae	91061|Bacilli	NT	Two component signalling adaptor domain	cheW	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006935,GO:0008150,GO:0009453,GO:0009605,GO:0040011,GO:0042221,GO:0042330,GO:0042333,GO:0044424,GO:0044444,GO:0044464,GO:0050896	-	ko:K03408	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheW
HKD2_k127_3175879_17	351607.Acel_1872	3.451e-58	218.0	COG0840@1|root,COG0840@2|Bacteria,2IA80@201174|Actinobacteria	201174|Actinobacteria	NT	chemotaxis	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CHASE3,MCPsignal
HKD2_k127_3175879_3	1223521.BBJX01000002_gene2825	5.523e-135	458.0	COG0643@1|root,COG0745@1|root,COG0643@2|Bacteria,COG0745@2|Bacteria,1MUAG@1224|Proteobacteria,2VJSZ@28216|Betaproteobacteria,4ACMW@80864|Comamonadaceae	28216|Betaproteobacteria	T	Two component signalling adaptor domain	-	GO:0003674,GO:0005488,GO:0005515,GO:0019904	2.7.13.3	ko:K03407,ko:K13490	ko02020,ko02025,ko02030,map02020,map02025,map02030	M00506,M00509	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	CheW,HATPase_c,Hpt,Response_reg
HKD2_k127_3175879_32	316274.Haur_0727	7.85e-27	111.0	COG2201@1|root,COG2201@2|Bacteria,2G8K7@200795|Chloroflexi,374TC@32061|Chloroflexia	32061|Chloroflexia	NT	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR	cheB	-	3.1.1.61,3.5.1.44	ko:K03412	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest,Response_reg
HKD2_k127_318185_3	479437.Elen_1035	2.604e-75	256.0	COG0112@1|root,COG0112@2|Bacteria,2GK7U@201174|Actinobacteria,4CV8R@84998|Coriobacteriia	84998|Coriobacteriia	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
HKD2_k127_318185_0	580327.Tthe_2529	2.101e-91	305.0	COG0035@1|root,COG0035@2|Bacteria,1TPMT@1239|Firmicutes,248FV@186801|Clostridia,42FSE@68295|Thermoanaerobacterales	186801|Clostridia	F	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate	upp	-	2.4.2.9	ko:K00761	ko00240,ko01100,map00240,map01100	-	R00966	RC00063	ko00000,ko00001,ko01000	-	-	-	UPRTase
HKD2_k127_318185_4	696369.KI912183_gene2117	1.962e-64	224.0	COG2131@1|root,COG2131@2|Bacteria,1V3PU@1239|Firmicutes,24HF0@186801|Clostridia,261R0@186807|Peptococcaceae	186801|Clostridia	F	PFAM Cytidine and deoxycytidylate deaminase zinc-binding region	comEB	-	3.5.4.12	ko:K01493	ko00240,ko01100,map00240,map01100	M00429	R01663	RC00074	ko00000,ko00001,ko00002,ko01000,ko02044	-	-	-	dCMP_cyt_deam_1
HKD2_k127_318185_2	1504822.CCNO01000015_gene678	1.16e-80	285.0	COG0472@1|root,COG0472@2|Bacteria,2NPJ8@2323|unclassified Bacteria	2|Bacteria	M	Glycosyl transferase family 4	rfe	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016043,GO:0016740,GO:0016772,GO:0016780,GO:0030145,GO:0034645,GO:0042546,GO:0043167,GO:0043169,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044464,GO:0045229,GO:0046872,GO:0046914,GO:0070589,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0071944,GO:1901576	2.7.8.33,2.7.8.35	ko:K02851	-	-	R08856	RC00002	ko00000,ko01000,ko01003,ko01005	-	-	-	Glycos_transf_4
HKD2_k127_318185_5	521003.COLINT_03378	2.625e-53	203.0	COG0356@1|root,COG0356@2|Bacteria,2H3PR@201174|Actinobacteria,4CV2N@84998|Coriobacteriia	84998|Coriobacteriia	C	it plays a direct role in the translocation of protons across the membrane	atpB	-	-	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1	-	-	ATP-synt_A
HKD2_k127_318185_8	1229780.BN381_10043	8.304e-18	86.0	COG0636@1|root,COG0636@2|Bacteria,2HGDC@201174|Actinobacteria,3UWZI@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpE	-	-	-	-	-	-	-	-	-	-	-	ATP-synt_C
HKD2_k127_318185_6	1235794.C811_00234	6.949e-36	143.0	COG0711@1|root,COG0711@2|Bacteria,2HUVJ@201174|Actinobacteria,4CVSF@84998|Coriobacteriia	84998|Coriobacteriia	C	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)	atpF	-	-	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_B
HKD2_k127_318185_7	479434.Sthe_1424	7.316e-25	113.0	COG0712@1|root,COG0712@2|Bacteria,2G78B@200795|Chloroflexi,27YHC@189775|Thermomicrobia	189775|Thermomicrobia	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpH	-	-	ko:K02113	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	OSCP
HKD2_k127_318185_1	1384484.AEQU_0743	1.44e-82	277.0	COG0056@1|root,COG0056@2|Bacteria,2GJRJ@201174|Actinobacteria,4CU9G@84998|Coriobacteriia	84998|Coriobacteriia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	atpA	-	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
HKD2_k127_3263738_11	1192034.CAP_6400	9.838e-19	87.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,42MHP@68525|delta/epsilon subdivisions,2WIQG@28221|Deltaproteobacteria,2YWF0@29|Myxococcales	28221|Deltaproteobacteria	I	Acetyl-coenzyme A synthetase N-terminus	acsA	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
HKD2_k127_3263738_3	246194.CHY_0483	7.606e-132	430.0	COG0407@1|root,COG0407@2|Bacteria,1TR8Q@1239|Firmicutes	1239|Firmicutes	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	hemE	GO:0003674,GO:0003824,GO:0004853,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.1.246,4.1.1.37	ko:K01599,ko:K14080	ko00680,ko00860,ko01100,ko01110,ko01120,ko01200,map00680,map00860,map01100,map01110,map01120,map01200	M00121,M00356	R03197,R04972,R09098,R10000	RC00035,RC00872,RC01144,RC02440	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
HKD2_k127_3263738_8	521098.Aaci_2090	2.912e-35	147.0	COG0276@1|root,COG0276@2|Bacteria,1TPKF@1239|Firmicutes,4HAYG@91061|Bacilli	91061|Bacilli	H	Catalyzes the ferrous insertion into protoporphyrin IX	hemH	GO:0003674,GO:0003824,GO:0004325,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.99.1.1,4.99.1.9	ko:K01772	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R00310,R11329	RC01012	ko00000,ko00001,ko00002,ko01000	-	-	-	Ferrochelatase
HKD2_k127_3263738_10	1536773.R70331_11125	1.231e-19	93.0	COG1232@1|root,COG1232@2|Bacteria,1TQ6W@1239|Firmicutes,4HAUG@91061|Bacilli,26RYF@186822|Paenibacillaceae	91061|Bacilli	H	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX	hemY	-	1.3.3.15,1.3.3.4	ko:K00231	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03222,R04178	RC00885	ko00000,ko00001,ko00002,ko01000	-	-	iSB619.SA_RS09325	Amino_oxidase
HKD2_k127_3263738_5	246194.CHY_0481	5.934e-77	271.0	COG1232@1|root,COG1232@2|Bacteria,1TQ6W@1239|Firmicutes,24IHQ@186801|Clostridia	186801|Clostridia	H	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX	-	-	1.3.3.15,1.3.3.4	ko:K00231	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03222,R04178	RC00885	ko00000,ko00001,ko00002,ko01000	-	-	-	Amino_oxidase
HKD2_k127_3263738_7	696747.NIES39_E01670	1.208e-50	191.0	COG0483@1|root,COG0483@2|Bacteria,1G0GD@1117|Cyanobacteria,1H7BK@1150|Oscillatoriales	1117|Cyanobacteria	G	Inositol monophosphatase family	suhB	GO:0003674,GO:0003824,GO:0005975,GO:0006020,GO:0006066,GO:0006793,GO:0006796,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0008934,GO:0009056,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019637,GO:0019751,GO:0023052,GO:0042578,GO:0043647,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0046164,GO:0046174,GO:0046434,GO:0046838,GO:0046855,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0052745,GO:0052834,GO:0065007,GO:0071545,GO:0071704,GO:1901575,GO:1901615,GO:1901616	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
HKD2_k127_3263738_0	584708.Apau_1587	3.448e-196	630.0	COG0021@1|root,COG0021@2|Bacteria,3TAH4@508458|Synergistetes	508458|Synergistetes	H	Belongs to the transketolase family	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
HKD2_k127_3263738_9	1235794.C811_00765	1.285e-26	118.0	COG0680@1|root,COG0680@2|Bacteria,2GSEX@201174|Actinobacteria,4CW0K@84998|Coriobacteriia	84998|Coriobacteriia	C	hydrogenase maturation protease	-	-	-	ko:K03605	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	HycI
HKD2_k127_3263738_2	479437.Elen_0037	5.086e-153	496.0	COG0635@1|root,COG0635@2|Bacteria,2GJ2W@201174|Actinobacteria,4CVEC@84998|Coriobacteriia	84998|Coriobacteriia	H	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
HKD2_k127_3263738_6	742742.HMPREF9452_01182	7.342e-62	220.0	COG1969@1|root,COG1969@2|Bacteria,2GUTZ@201174|Actinobacteria,4CUB3@84998|Coriobacteriia	84998|Coriobacteriia	C	Cytochrome b/b6/petB	-	-	-	ko:K03620	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	Ni_hydr_CYTB
HKD2_k127_3263738_1	469378.Ccur_08540	3.202e-179	574.0	COG0374@1|root,COG0374@2|Bacteria,2GKQY@201174|Actinobacteria,4CVAH@84998|Coriobacteriia	84998|Coriobacteriia	C	Nickel-dependent hydrogenase	-	-	1.12.99.6	ko:K06281	ko00633,ko01120,map00633,map01120	-	R08034	RC00250	ko00000,ko00001,ko01000	-	-	-	NiFeSe_Hases
HKD2_k127_3263738_4	742818.HMPREF9451_00853	1.769e-119	396.0	COG1740@1|root,COG1740@2|Bacteria,2GKF2@201174|Actinobacteria,4CV4A@84998|Coriobacteriia	84998|Coriobacteriia	C	NiFe/NiFeSe hydrogenase small subunit C-terminal	-	-	1.12.99.6	ko:K06282	ko00633,ko01120,map00633,map01120	-	R08034	RC00250	ko00000,ko00001,ko01000	-	-	-	NiFe_hyd_SSU_C,Oxidored_q6
HKD2_k127_3325752_5	635013.TherJR_0839	1.11e-67	236.0	COG0118@1|root,COG0118@2|Bacteria,1TQT0@1239|Firmicutes,248SH@186801|Clostridia,260M0@186807|Peptococcaceae	186801|Clostridia	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR	hisH	-	-	ko:K02501	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
HKD2_k127_3325752_4	401526.TcarDRAFT_2694	7.043e-68	238.0	COG0106@1|root,COG0106@2|Bacteria,1V1IR@1239|Firmicutes,4H25R@909932|Negativicutes	909932|Negativicutes	E	1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase	hisA	-	5.3.1.16	ko:K01814	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04640	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
HKD2_k127_3325752_3	1125712.HMPREF1316_1600	2.841e-105	354.0	COG0107@1|root,COG0107@2|Bacteria,2GIRP@201174|Actinobacteria,4CUUE@84998|Coriobacteriia	84998|Coriobacteriia	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit	hisF	-	-	ko:K02500	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
HKD2_k127_3325752_7	246194.CHY_1091	1.493e-40	154.0	COG0139@1|root,COG0140@1|root,COG0139@2|Bacteria,COG0140@2|Bacteria,1UYNA@1239|Firmicutes,247RS@186801|Clostridia,42F6A@68295|Thermoanaerobacterales	186801|Clostridia	E	Histidine biosynthesis bifunctional protein hisIE	hisI	-	3.5.4.19,3.6.1.31	ko:K01496,ko:K11755	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04035,R04037	RC00002,RC01055	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS05760	His_biosynth,PRA-CH,PRA-PH
HKD2_k127_3325752_12	1118060.CAGZ01000033_gene1467	2.854e-20	94.0	COG0140@1|root,COG0140@2|Bacteria,2HV29@201174|Actinobacteria,4CW6R@84998|Coriobacteriia	84998|Coriobacteriia	E	Phosphoribosyl-ATP pyrophosphohydrolase	hisE	-	3.6.1.31	ko:K01523	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	PRA-PH
HKD2_k127_3325752_13	743720.Psefu_2946	9.713e-12	77.0	COG0501@1|root,COG0501@2|Bacteria,1MVU4@1224|Proteobacteria,1RPJ5@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	Zn-dependent protease with chaperone function	-	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
HKD2_k127_3325752_10	1304874.JAFY01000005_gene1320	2.476e-33	139.0	COG3467@1|root,COG3467@2|Bacteria,3TBB5@508458|Synergistetes	508458|Synergistetes	S	Pyridoxamine 5'-phosphate oxidase	-	-	-	ko:K07005	-	-	-	-	ko00000	-	-	-	Pyridox_ox_2
HKD2_k127_3325752_11	562970.Btus_0242	1.431e-27	116.0	COG0640@1|root,COG0640@2|Bacteria,1VA3M@1239|Firmicutes,4HKWM@91061|Bacilli,278KM@186823|Alicyclobacillaceae	91061|Bacilli	K	ArsR family transcriptional regulator	sdpR	GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0044212,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
HKD2_k127_3325752_9	697281.Mahau_2660	7.27e-38	154.0	COG5658@1|root,COG5658@2|Bacteria,1VBIT@1239|Firmicutes,24HIG@186801|Clostridia,42G4X@68295|Thermoanaerobacterales	186801|Clostridia	S	Protein of unknown function (DUF1648)	sdpI	-	-	-	-	-	-	-	-	-	-	-	DUF1648,SdpI
HKD2_k127_3325752_1	243231.GSU2383	1.568e-144	477.0	COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,42MXN@68525|delta/epsilon subdivisions,2WJN0@28221|Deltaproteobacteria,43TZF@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia	trpE	-	4.1.3.27	ko:K01657,ko:K13503	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
HKD2_k127_3325752_2	1069080.KB913028_gene1787	2.096e-134	449.0	COG0512@1|root,COG0547@1|root,COG0512@2|Bacteria,COG0547@2|Bacteria,1TP8U@1239|Firmicutes,4H1UK@909932|Negativicutes	909932|Negativicutes	E	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)	trpD	-	2.4.2.18	ko:K00766	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R01073	RC00440	ko00000,ko00001,ko00002,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3
HKD2_k127_3325752_8	345219.Bcoa_2095	1.597e-40	167.0	COG0134@1|root,COG0135@1|root,COG0134@2|Bacteria,COG0135@2|Bacteria,1TR94@1239|Firmicutes,4HDZQ@91061|Bacilli,1ZD63@1386|Bacillus	91061|Bacilli	E	Belongs to the TrpC family	trpC	GO:0003674,GO:0003824,GO:0004425,GO:0016829,GO:0016830,GO:0016831	4.1.1.48,5.3.1.24	ko:K01609,ko:K13498	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03508,R03509	RC00944,RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPS
HKD2_k127_3325752_6	1121430.JMLG01000010_gene187	7.984e-42	173.0	COG0135@1|root,COG0135@2|Bacteria,1V6Y0@1239|Firmicutes,24HBQ@186801|Clostridia,2623G@186807|Peptococcaceae	186801|Clostridia	E	Belongs to the TrpF family	trpF	-	5.3.1.24	ko:K01817	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03509	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	PRAI
HKD2_k127_3325752_0	1089553.Tph_c26500	2.182e-145	469.0	COG0133@1|root,COG0133@2|Bacteria,1TPI3@1239|Firmicutes,24881@186801|Clostridia,42EWK@68295|Thermoanaerobacterales	186801|Clostridia	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB	-	4.2.1.20	ko:K01696	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HKD2_k127_340133_2	469378.Ccur_00100	5.299e-120	391.0	COG1217@1|root,COG1217@2|Bacteria,2GJUJ@201174|Actinobacteria,4CUBE@84998|Coriobacteriia	84998|Coriobacteriia	T	GTP-binding protein TypA	typA	-	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2
HKD2_k127_340133_8	1089553.Tph_c15310	2.782e-48	195.0	COG0535@1|root,COG0535@2|Bacteria,1TR85@1239|Firmicutes,249NQ@186801|Clostridia,42FAP@68295|Thermoanaerobacterales	186801|Clostridia	C	SMART Elongator protein 3 MiaB NifB	-	-	-	ko:K22226	-	-	-	-	ko00000	-	-	-	Fer4_12,Radical_SAM,SPASM
HKD2_k127_340133_11	1384054.N790_07395	1.381e-39	150.0	COG1695@1|root,COG1695@2|Bacteria,1NJSY@1224|Proteobacteria,1SG6R@1236|Gammaproteobacteria,1X6UG@135614|Xanthomonadales	135614|Xanthomonadales	K	PadR family transcriptional regulator	-	-	-	ko:K10947	-	-	-	-	ko00000,ko03000	-	-	-	PadR
HKD2_k127_340133_5	925775.XVE_2829	3.154e-84	289.0	COG4709@1|root,COG4709@2|Bacteria,1NX5K@1224|Proteobacteria,1SPS6@1236|Gammaproteobacteria,1X34I@135614|Xanthomonadales	135614|Xanthomonadales	S	Putative sensor	-	-	-	-	-	-	-	-	-	-	-	-	Sensor
HKD2_k127_340133_17	555088.DealDRAFT_2728	1.802e-13	83.0	COG4758@1|root,COG4758@2|Bacteria,1UITP@1239|Firmicutes,24NAQ@186801|Clostridia	186801|Clostridia	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF2154,Toast_rack_N
HKD2_k127_340133_23	1094980.Mpsy_1256	0.0001427	48.0	arCOG03492@1|root,arCOG03492@2157|Archaea,2Y5WG@28890|Euryarchaeota,2NBFI@224756|Methanomicrobia	224756|Methanomicrobia	S	Phospholipase_D-nuclease N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	PLDc_N
HKD2_k127_340133_4	1329516.JPST01000035_gene3230	2.408e-94	323.0	COG0656@1|root,COG0656@2|Bacteria,1TPM1@1239|Firmicutes,4HARE@91061|Bacilli,27BA5@186824|Thermoactinomycetaceae	91061|Bacilli	S	Aldo/keto reductase family	yvgN	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
HKD2_k127_340133_9	555088.DealDRAFT_3054	2.632e-47	181.0	COG0778@1|root,COG0778@2|Bacteria,1UZC3@1239|Firmicutes,24BKG@186801|Clostridia	186801|Clostridia	C	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	TM1586_NiRdase
HKD2_k127_340133_13	1463934.JOCF01000081_gene5659	4.533e-24	108.0	COG0791@1|root,COG3409@1|root,COG0791@2|Bacteria,COG3409@2|Bacteria,2I61A@201174|Actinobacteria	201174|Actinobacteria	M	Peptidoglycan-binding domain 1 protein	-	-	-	-	-	-	-	-	-	-	-	-	NLPC_P60,PG_binding_1
HKD2_k127_340133_6	1463821.JOGR01000010_gene3837	4.088e-62	233.0	COG1835@1|root,COG1835@2|Bacteria,2GKUS@201174|Actinobacteria	201174|Actinobacteria	I	Acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
HKD2_k127_340133_7	1286171.EAL2_c15310	5.526e-49	196.0	COG0103@1|root,COG5263@1|root,COG0103@2|Bacteria,COG5263@2|Bacteria,1V2GT@1239|Firmicutes,24EI0@186801|Clostridia,25XDA@186806|Eubacteriaceae	186801|Clostridia	L	WG containing repeat	-	-	-	-	-	-	-	-	-	-	-	-	Cu_amine_oxidN1,WG_beta_rep
HKD2_k127_340133_21	502558.EGYY_28740	1.294e-08	64.0	COG0515@1|root,COG2815@1|root,COG0515@2|Bacteria,COG2815@2|Bacteria,2GJ1J@201174|Actinobacteria,4CUKV@84998|Coriobacteriia	84998|Coriobacteriia	KLT	Kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
HKD2_k127_340133_1	398512.JQKC01000004_gene5249	1.248e-132	455.0	COG0574@1|root,COG3848@1|root,COG0574@2|Bacteria,COG3848@2|Bacteria,1UIEA@1239|Firmicutes,25EJM@186801|Clostridia,3WI29@541000|Ruminococcaceae	186801|Clostridia	GT	Pyruvate phosphate dikinase, PEP/pyruvate binding domain	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
HKD2_k127_340133_20	1121272.KB903250_gene2682	6.812e-09	66.0	COG1309@1|root,COG1309@2|Bacteria,2GJZJ@201174|Actinobacteria,4DJ04@85008|Micromonosporales	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
HKD2_k127_340133_10	926554.KI912617_gene4785	4.495e-41	165.0	COG4430@1|root,COG4430@2|Bacteria	2|Bacteria	F	Bacteriocin-protection, YdeI or OmpD-Associated	-	-	-	-	-	-	-	-	-	-	-	-	OmdA
HKD2_k127_340133_22	1121918.ARWE01000001_gene3217	6.541e-06	53.0	2DHQR@1|root,300KJ@2|Bacteria,1Q6C0@1224|Proteobacteria,432U6@68525|delta/epsilon subdivisions,2WYED@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Dehyd-heme_bind
HKD2_k127_340133_3	118166.JH976537_gene2787	1.225e-101	341.0	COG0053@1|root,COG0053@2|Bacteria,1G361@1117|Cyanobacteria,1HE5W@1150|Oscillatoriales	1117|Cyanobacteria	P	TIGRFAM cation diffusion facilitator family transporter	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,ZT_dimer
HKD2_k127_340133_14	1184609.KILIM_019_00150	4.792e-20	98.0	COG1309@1|root,COG1309@2|Bacteria,2GNBI@201174|Actinobacteria	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C,TetR_N
HKD2_k127_340133_0	1267005.KB911258_gene500	7.32e-168	538.0	COG0015@1|root,COG0015@2|Bacteria,1MV4B@1224|Proteobacteria,2TQUE@28211|Alphaproteobacteria,3N6DZ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily	purB	GO:0003674,GO:0003824,GO:0004018,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016829,GO:0016840,GO:0016842,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046033,GO:0046390,GO:0046483,GO:0055086,GO:0070626,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	-	ADSL_C,Lyase_1
HKD2_k127_340133_16	1095743.HMPREF1054_1267	2.521e-14	79.0	COG1525@1|root,COG1525@2|Bacteria,1NNMW@1224|Proteobacteria,1T2SY@1236|Gammaproteobacteria,1YAZN@135625|Pasteurellales	135625|Pasteurellales	L	Excalibur calcium-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Excalibur
HKD2_k127_340133_18	1502851.FG93_03814	5.053e-12	78.0	COG0201@1|root,COG0201@2|Bacteria,1MVU7@1224|Proteobacteria,2TQMT@28211|Alphaproteobacteria,3JST3@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	-	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	SecY
HKD2_k127_340133_15	765698.Mesci_4453	3.095e-19	95.0	COG3637@1|root,COG3637@2|Bacteria	2|Bacteria	M	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety	-	-	-	ko:K07275,ko:K16079	-	-	-	-	ko00000,ko02000	1.B.4.2.1	-	-	OMP_b-brl
HKD2_k127_3858650_14	635013.TherJR_0259	0.000191	50.0	COG1969@1|root,COG1969@2|Bacteria,1V22Y@1239|Firmicutes,24H7X@186801|Clostridia,261Q0@186807|Peptococcaceae	186801|Clostridia	C	TIGRFAM Ni Fe-hydrogenase, b-type cytochrome subunit	-	-	-	ko:K03620	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	Ni_hydr_CYTB
HKD2_k127_3858650_1	717605.Theco_3770	2.749e-104	351.0	COG0520@1|root,COG0520@2|Bacteria,1TQ1W@1239|Firmicutes,4HDS3@91061|Bacilli,26SPW@186822|Paenibacillaceae	91061|Bacilli	E	Cysteine desulfurase	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
HKD2_k127_3858650_10	646529.Desaci_0783	1.404e-43	172.0	COG0521@1|root,COG0521@2|Bacteria,1V3XM@1239|Firmicutes,24HG2@186801|Clostridia,261XV@186807|Peptococcaceae	186801|Clostridia	H	TIGRFAM molybdenum cofactor synthesis	mog	-	-	-	-	-	-	-	-	-	-	-	MOSC,MoCF_biosynth
HKD2_k127_3858650_7	479437.Elen_0255	9.577e-60	212.0	COG2258@1|root,COG2258@2|Bacteria,2GMBE@201174|Actinobacteria,4CVNR@84998|Coriobacteriia	84998|Coriobacteriia	S	MOSC domain	-	-	-	-	-	-	-	-	-	-	-	-	MOSC
HKD2_k127_3858650_9	1535287.JP74_16545	3.385e-54	194.0	COG0315@1|root,COG0315@2|Bacteria,1RCYZ@1224|Proteobacteria,2U747@28211|Alphaproteobacteria,3N6ZS@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)	moaC	-	4.6.1.17	ko:K03637	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R11372	RC03425	ko00000,ko00001,ko01000	-	-	-	MoaC
HKD2_k127_3858650_0	742818.HMPREF9451_01438	3.66e-119	394.0	COG2896@1|root,COG2896@2|Bacteria,2GN0V@201174|Actinobacteria,4CUGB@84998|Coriobacteriia	84998|Coriobacteriia	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	-	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Fer4_14,Mob_synth_C,Radical_SAM
HKD2_k127_3858650_12	401526.TcarDRAFT_0831	6.654e-39	151.0	COG1763@1|root,COG1763@2|Bacteria,1VFA0@1239|Firmicutes,4H494@909932|Negativicutes	909932|Negativicutes	H	molybdopterin-guanine dinucleotide biosynthesis protein	-	-	-	ko:K03753	-	-	-	-	ko00000	-	-	-	MobB
HKD2_k127_3858650_13	760568.Desku_2909	3.042e-06	59.0	2DSKT@1|root,33GJ4@2|Bacteria,1VKB9@1239|Firmicutes,24VAK@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3858650_2	1128421.JAGA01000002_gene1035	4.283e-101	343.0	COG0303@1|root,COG0303@2|Bacteria,2NP4N@2323|unclassified Bacteria	2|Bacteria	H	MoeA N-terminal region (domain I and II)	moeA	-	2.10.1.1	ko:K03750	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N
HKD2_k127_3858650_5	635013.TherJR_2345	8.65e-64	237.0	COG0746@1|root,COG1526@1|root,COG0746@2|Bacteria,COG1526@2|Bacteria,1TU8R@1239|Firmicutes,24G61@186801|Clostridia,261G6@186807|Peptococcaceae	186801|Clostridia	C	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH	fdhD	-	-	ko:K02379	-	-	-	-	ko00000	-	-	-	FdhD-NarQ
HKD2_k127_3858650_4	671143.DAMO_1145	3.95e-72	258.0	COG3842@1|root,COG3842@2|Bacteria,2NNPE@2323|unclassified Bacteria	2|Bacteria	E	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system	gtsA	-	3.6.3.25,3.6.3.30,3.6.3.31,3.6.3.55	ko:K02010,ko:K02045,ko:K02049,ko:K02068,ko:K02071,ko:K06857,ko:K10112,ko:K11072	ko00920,ko02010,map00920,map02010	M00185,M00186,M00188,M00190,M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00211,M00238,M00299,M00491,M00602,M00605,M00606	R10531	RC00002	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.1,3.A.1.10,3.A.1.11.1,3.A.1.16,3.A.1.17,3.A.1.24,3.A.1.6.1,3.A.1.6.2,3.A.1.6.3,3.A.1.6.4	-	-	ABC_tran,TOBE_2
HKD2_k127_3858650_8	1121472.AQWN01000008_gene1950	1.593e-57	210.0	COG4662@1|root,COG4662@2|Bacteria,1TRK7@1239|Firmicutes,249VG@186801|Clostridia,260GI@186807|Peptococcaceae	186801|Clostridia	P	PFAM binding-protein-dependent transport systems inner membrane component	tupB	-	-	ko:K05773	ko02010,map02010	M00186	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.2,3.A.1.6.4	-	-	BPD_transp_1
HKD2_k127_3858650_3	56780.SYN_00837	6.618e-78	277.0	COG2998@1|root,COG2998@2|Bacteria,1MVSF@1224|Proteobacteria,42NK5@68525|delta/epsilon subdivisions,2WM49@28221|Deltaproteobacteria,2MQA9@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	Bacterial extracellular solute-binding protein	-	-	-	ko:K05772	ko02010,map02010	M00186	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.2,3.A.1.6.4	-	-	PBP_like_2
HKD2_k127_3858650_11	56780.SYN_00837	5.865e-40	159.0	COG2998@1|root,COG2998@2|Bacteria,1MVSF@1224|Proteobacteria,42NK5@68525|delta/epsilon subdivisions,2WM49@28221|Deltaproteobacteria,2MQA9@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	Bacterial extracellular solute-binding protein	-	-	-	ko:K05772	ko02010,map02010	M00186	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.2,3.A.1.6.4	-	-	PBP_like_2
HKD2_k127_3858650_6	635013.TherJR_1984	1.846e-62	226.0	COG0583@1|root,COG0583@2|Bacteria,1TSA6@1239|Firmicutes,24BM8@186801|Clostridia,26199@186807|Peptococcaceae	186801|Clostridia	K	LysR substrate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HKD2_k127_3904148_32	469378.Ccur_05180	3.682e-06	48.0	COG0231@1|root,COG0231@2|Bacteria,2GJMS@201174|Actinobacteria,4CV48@84998|Coriobacteriia	84998|Coriobacteriia	J	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase	efp	-	-	ko:K02356	-	-	-	-	ko00000,ko03012	-	-	-	EFP,EFP_N,Elong-fact-P_C
HKD2_k127_3904148_12	273068.TTE1280	8.962e-80	285.0	COG0006@1|root,COG0006@2|Bacteria,1TQ44@1239|Firmicutes,247SG@186801|Clostridia,42F13@68295|Thermoanaerobacterales	186801|Clostridia	E	PFAM peptidase M24	-	-	3.4.11.9,3.4.13.9	ko:K01262,ko:K01271	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Peptidase_M24
HKD2_k127_3904148_18	479437.Elen_2547	5.062e-53	190.0	COG0757@1|root,COG0757@2|Bacteria,2IMBY@201174|Actinobacteria,4CVUU@84998|Coriobacteriia	84998|Coriobacteriia	E	Catalyzes a trans-dehydration via an enolate intermediate	aroQ	-	4.2.1.10	ko:K03786	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03084	RC00848	ko00000,ko00001,ko00002,ko01000	-	-	-	DHquinase_II,PTS_EIIB
HKD2_k127_3904148_11	479437.Elen_2548	1.02e-87	307.0	COG0337@1|root,COG0337@2|Bacteria,2GIUZ@201174|Actinobacteria,4CUIE@84998|Coriobacteriia	84998|Coriobacteriia	E	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)	aroB	-	4.2.3.4	ko:K01735	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03083	RC00847	ko00000,ko00001,ko00002,ko01000	-	-	-	DHQ_synthase
HKD2_k127_3904148_23	1120985.AUMI01000014_gene1190	4.702e-34	140.0	COG0703@1|root,COG0703@2|Bacteria,1VA6Z@1239|Firmicutes,4H4XC@909932|Negativicutes	909932|Negativicutes	E	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate	aroK	-	2.7.1.71	ko:K00891	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	SKI
HKD2_k127_3904148_7	401526.TcarDRAFT_1551	1.431e-114	385.0	COG0082@1|root,COG0082@2|Bacteria,1TQ40@1239|Firmicutes,4H375@909932|Negativicutes	909932|Negativicutes	E	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system	aroC	-	4.2.3.5	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01714	RC00586	ko00000,ko00001,ko00002,ko01000	-	-	-	Chorismate_synt
HKD2_k127_3904148_33	666681.M301_2566	0.000184	51.0	COG3167@1|root,COG3167@2|Bacteria,1RBGW@1224|Proteobacteria,2VH68@28216|Betaproteobacteria,2KKDE@206350|Nitrosomonadales	206350|Nitrosomonadales	NU	PFAM Pilus assembly protein PilO	-	-	-	ko:K02664	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilO
HKD2_k127_3904148_31	351607.Acel_1312	2.287e-06	57.0	COG3166@1|root,COG3166@2|Bacteria	2|Bacteria	NU	PFAM Fimbrial assembly family protein	pilN	-	-	ko:K02663	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilN
HKD2_k127_3904148_15	351607.Acel_1313	2.883e-62	228.0	COG4972@1|root,COG4972@2|Bacteria,2IBNF@201174|Actinobacteria,4ET6Y@85013|Frankiales	201174|Actinobacteria	NU	Type IV pilus assembly protein PilM;	pilM	-	-	ko:K02662	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilM_2
HKD2_k127_3904148_30	590998.Celf_2000	1.543e-06	62.0	COG4967@1|root,COG4967@2|Bacteria,2H747@201174|Actinobacteria	201174|Actinobacteria	NU	Prokaryotic N-terminal methylation motif	-	-	-	-	-	-	-	-	-	-	-	-	N_methyl
HKD2_k127_3904148_20	1125863.JAFN01000001_gene1507	5.515e-47	181.0	COG1989@1|root,COG1989@2|Bacteria,1MUZF@1224|Proteobacteria,42S2A@68525|delta/epsilon subdivisions,2WMQ8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	NOU	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue	pilD	-	3.4.23.43	ko:K02654	-	M00331	-	-	ko00000,ko00002,ko01000,ko01002,ko02035,ko02044	3.A.15.2	-	-	DiS_P_DiS,Peptidase_A24
HKD2_k127_3904148_29	485916.Dtox_3248	2.573e-11	76.0	COG2165@1|root,COG2165@2|Bacteria,1VK8F@1239|Firmicutes,24UDT@186801|Clostridia	186801|Clostridia	NU	prepilin-type N-terminal cleavage methylation domain	-	-	-	ko:K02456,ko:K02650	ko02020,ko03070,ko05111,map02020,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15,3.A.15.2	-	-	N_methyl
HKD2_k127_3904148_8	1380390.JIAT01000017_gene5296	1.803e-103	349.0	COG1459@1|root,COG1459@2|Bacteria,2GQW0@201174|Actinobacteria,4CPUI@84995|Rubrobacteria	84995|Rubrobacteria	NU	COG COG1459 Type II secretory pathway component PulF Cell motility and secretion Intracellular trafficking and secretion	-	-	-	ko:K02653	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSF
HKD2_k127_3904148_6	351607.Acel_1321	1.421e-137	446.0	COG2805@1|root,COG2805@2|Bacteria,2I9GT@201174|Actinobacteria,4ES1W@85013|Frankiales	201174|Actinobacteria	NU	Type II/IV secretion system protein	pilT	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
HKD2_k127_3904148_2	351607.Acel_1322	4.439e-197	635.0	COG2804@1|root,COG2804@2|Bacteria,2I8C2@201174|Actinobacteria,4ES0V@85013|Frankiales	201174|Actinobacteria	NU	General secretory system II, protein E domain protein	-	-	-	ko:K02652	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE,T2SSE_N
HKD2_k127_3904148_16	351607.Acel_1323	7.697e-59	209.0	COG2229@1|root,COG2229@2|Bacteria,2HI46@201174|Actinobacteria,4EVUB@85013|Frankiales	201174|Actinobacteria	S	Conserved hypothetical ATP binding protein	cvnD10	-	-	ko:K06945	-	-	-	-	ko00000	-	-	-	ATP_bind_1
HKD2_k127_3904148_22	316274.Haur_0845	4.91e-39	167.0	COG0457@1|root,COG0457@2|Bacteria,2G770@200795|Chloroflexi,374ST@32061|Chloroflexia	32061|Chloroflexia	S	Domain of unknown function (DUF4388)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4388
HKD2_k127_3904148_25	1521187.JPIM01000002_gene3124	1.231e-31	134.0	COG2018@1|root,COG2018@2|Bacteria,2G8WW@200795|Chloroflexi,375M5@32061|Chloroflexia	32061|Chloroflexia	S	PFAM Roadblock LC7 family protein	-	-	-	ko:K07131	-	-	-	-	ko00000	-	-	-	Robl_LC7
HKD2_k127_3904148_3	351607.Acel_1322	1.578e-179	582.0	COG2804@1|root,COG2804@2|Bacteria,2I8C2@201174|Actinobacteria,4ES0V@85013|Frankiales	201174|Actinobacteria	NU	General secretory system II, protein E domain protein	-	-	-	ko:K02652	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE,T2SSE_N
HKD2_k127_3904148_17	868595.Desca_2188	4.195e-57	210.0	COG0169@1|root,COG0169@2|Bacteria,1TQRY@1239|Firmicutes,2497S@186801|Clostridia,2619R@186807|Peptococcaceae	186801|Clostridia	E	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)	aroE	-	1.1.1.25	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413	RC00206	ko00000,ko00001,ko00002,ko01000	-	-	-	Shikimate_DH,Shikimate_dh_N
HKD2_k127_3904148_21	502558.EGYY_04670	1.425e-39	161.0	COG2179@1|root,COG2179@2|Bacteria,2HTFS@201174|Actinobacteria,4CVXP@84998|Coriobacteriia	84998|Coriobacteriia	S	HAD superfamily (Subfamily IIIA) phosphatase, TIGR01668	yqeG	-	-	ko:K07015	-	-	-	-	ko00000	-	-	-	Hydrolase_like
HKD2_k127_3904148_28	661478.OP10G_3704	3.713e-13	78.0	COG1277@1|root,COG1277@2|Bacteria	2|Bacteria	-	-	pilI	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane_2
HKD2_k127_3904148_14	404589.Anae109_0681	3.41e-64	232.0	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,42NSM@68525|delta/epsilon subdivisions,2WJXQ@28221|Deltaproteobacteria,2YXY8@29|Myxococcales	28221|Deltaproteobacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	pilH	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD2_k127_3904148_13	1236976.JCM16418_834	8.136e-72	258.0	COG1559@1|root,COG1559@2|Bacteria,1TS48@1239|Firmicutes,4HAUV@91061|Bacilli,26Q9M@186822|Paenibacillaceae	91061|Bacilli	S	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation	mltG	-	-	ko:K07082	-	-	-	-	ko00000	-	-	-	YceG
HKD2_k127_3904148_24	1504822.CCNO01000014_gene1107	3.303e-33	144.0	COG0816@1|root,COG0816@2|Bacteria	2|Bacteria	L	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA	yqgF	GO:0000966,GO:0000967,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008296,GO:0008408,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0022613,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0040007,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0140097,GO:1901360	-	ko:K07447	-	-	-	-	ko00000,ko01000	-	-	-	RuvX
HKD2_k127_3904148_0	502558.EGYY_04640	1.651e-312	979.0	COG0013@1|root,COG0013@2|Bacteria,2GIUG@201174|Actinobacteria,4CV1V@84998|Coriobacteriia	84998|Coriobacteriia	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
HKD2_k127_3904148_19	742818.HMPREF9451_01187	1.89e-50	202.0	COG0628@1|root,COG0628@2|Bacteria,2GN4Y@201174|Actinobacteria,4CU8I@84998|Coriobacteriia	84998|Coriobacteriia	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
HKD2_k127_3904148_10	661087.HMPREF1008_01272	9.347e-91	312.0	COG1191@1|root,COG1191@2|Bacteria,2GKSY@201174|Actinobacteria,4CUM2@84998|Coriobacteriia	84998|Coriobacteriia	K	RNA polymerase sigma-70 factor, sigma-B F G subfamily	-	-	-	ko:K03090	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r3,Sigma70_r4
HKD2_k127_3904148_27	1111135.HMPREF1248_1454	2.804e-19	93.0	2CC5V@1|root,344S8@2|Bacteria,2HV3H@201174|Actinobacteria,4CW8P@84998|Coriobacteriia	84998|Coriobacteriia	-	-	-	-	2.7.11.1	ko:K04757	-	-	-	-	ko00000,ko01000,ko01001,ko03021	-	-	-	-
HKD2_k127_3904148_34	479437.Elen_2557	0.0007236	47.0	COG4768@1|root,COG4768@2|Bacteria,2II1J@201174|Actinobacteria,4CW0W@84998|Coriobacteriia	84998|Coriobacteriia	S	Bacterial protein of unknown function (DUF948)	-	-	-	-	-	-	-	-	-	-	-	-	DUF948
HKD2_k127_3904148_4	633147.Olsu_1132	3.421e-166	533.0	COG2256@1|root,COG2256@2|Bacteria,2GKDP@201174|Actinobacteria,4CUTC@84998|Coriobacteriia	84998|Coriobacteriia	L	PFAM AAA ATPase central domain protein	-	-	-	ko:K07478	-	-	-	-	ko00000	-	-	-	AAA,AAA_assoc_2,MgsA_C,RuvB_N
HKD2_k127_3904148_1	502558.EGYY_08050	3.235e-219	696.0	COG0173@1|root,COG0173@2|Bacteria,2GJHU@201174|Actinobacteria,4CUY4@84998|Coriobacteriia	84998|Coriobacteriia	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
HKD2_k127_3904148_5	502558.EGYY_22010	1.205e-142	476.0	COG0124@1|root,COG0124@2|Bacteria,2GIYJ@201174|Actinobacteria,4CV2W@84998|Coriobacteriia	84998|Coriobacteriia	J	histidyl-tRNA synthetase	hisS	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA-synt_His
HKD2_k127_3904148_26	526225.Gobs_5014	1.388e-24	107.0	COG0239@1|root,COG0239@2|Bacteria,2IKM1@201174|Actinobacteria,4ETDI@85013|Frankiales	201174|Actinobacteria	D	Important for reducing fluoride concentration in the cell, thus reducing its toxicity	crcB	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661,GO:1903424,GO:1903425	-	ko:K06199	-	-	-	-	ko00000,ko02000	1.A.43.1,1.A.43.2,1.A.43.3	-	-	CRCB
HKD2_k127_3904148_9	748247.AZKH_0382	3.859e-94	318.0	COG0318@1|root,COG0318@2|Bacteria	2|Bacteria	IQ	PFAM AMP-dependent synthetase and ligase	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	LuxE
HKD2_k127_3951125_0	696281.Desru_2177	8.632e-195	623.0	COG1615@1|root,COG1615@2|Bacteria,1TQHM@1239|Firmicutes,248PM@186801|Clostridia,260EY@186807|Peptococcaceae	186801|Clostridia	S	PFAM Uncharacterised protein family UPF0182	-	-	-	ko:K09118	-	-	-	-	ko00000	-	-	-	UPF0182
HKD2_k127_3951125_16	553184.ATORI0001_1323	4.013e-18	94.0	2F59P@1|root,33XVV@2|Bacteria,2HUVG@201174|Actinobacteria,4CVSE@84998|Coriobacteriia	84998|Coriobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3951125_1	502558.EGYY_28180	1.987e-166	539.0	COG1167@1|root,COG1167@2|Bacteria,2GITW@201174|Actinobacteria,4CUPT@84998|Coriobacteriia	84998|Coriobacteriia	EK	Alanine-glyoxylate amino-transferase	-	-	-	ko:K05825	ko00300,ko01100,ko01130,ko01210,map00300,map01100,map01130,map01210	-	R01939	RC00006	ko00000,ko00001,ko01000	-	-	-	Aminotran_1_2
HKD2_k127_3951125_4	1150864.MILUP08_30213	1.668e-91	311.0	COG1181@1|root,COG1181@2|Bacteria,2GRWM@201174|Actinobacteria,4DA6S@85008|Micromonosporales	201174|Actinobacteria	M	Belongs to the D-alanine--D-alanine ligase family	ddl	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C,Dala_Dala_lig_N
HKD2_k127_3951125_20	742818.HMPREF9451_00014	1.901e-08	64.0	COG3881@1|root,COG3881@2|Bacteria,2I6A5@201174|Actinobacteria,4CURS@84998|Coriobacteriia	84998|Coriobacteriia	S	PFAM PRC-barrel domain	-	-	-	-	-	-	-	-	-	-	-	-	PRC
HKD2_k127_3951125_12	1120934.KB894421_gene2528	1.238e-42	164.0	COG3153@1|root,COG3153@2|Bacteria,2GNNB@201174|Actinobacteria,4DXW4@85010|Pseudonocardiales	201174|Actinobacteria	S	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HKD2_k127_3951125_14	67257.JODR01000011_gene5459	2.411e-26	116.0	COG2606@1|root,COG2606@2|Bacteria,2IKUX@201174|Actinobacteria	201174|Actinobacteria	S	YbaK prolyl-tRNA synthetase associated region	-	-	-	-	-	-	-	-	-	-	-	-	tRNA_edit
HKD2_k127_3951125_11	552531.BIF_00991	1.097e-44	180.0	COG0726@1|root,COG0726@2|Bacteria,2GN6G@201174|Actinobacteria,4D08Y@85004|Bifidobacteriales	201174|Actinobacteria	G	Polysaccharide deacetylase	-	-	3.2.1.8,3.5.1.104	ko:K01181,ko:K22278	-	-	-	-	ko00000,ko01000	-	-	-	Polysacc_deac_1
HKD2_k127_3951125_15	596151.DesfrDRAFT_2777	1.678e-25	113.0	COG0212@1|root,COG0212@2|Bacteria,1MZG0@1224|Proteobacteria,42TZ2@68525|delta/epsilon subdivisions,2WQJG@28221|Deltaproteobacteria,2MC1P@213115|Desulfovibrionales	28221|Deltaproteobacteria	H	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family	-	-	6.3.3.2	ko:K01934	ko00670,ko01100,map00670,map01100	-	R02301	RC00183	ko00000,ko00001,ko01000	-	-	-	5-FTHF_cyc-lig
HKD2_k127_3951125_3	479437.Elen_0075	3.733e-138	451.0	COG1914@1|root,COG1914@2|Bacteria,2HGJ6@201174|Actinobacteria,4CV4V@84998|Coriobacteriia	84998|Coriobacteriia	P	Metal ion transporter, metal ion (Mn2 Fe2 ) transporter (Nramp) family	-	-	-	-	-	-	-	-	-	-	-	-	Nramp
HKD2_k127_3951125_2	502558.EGYY_01540	6.768e-154	508.0	COG2239@1|root,COG2239@2|Bacteria,2GMMK@201174|Actinobacteria,4CUUS@84998|Coriobacteriia	84998|Coriobacteriia	P	Magnesium transporter	-	-	-	ko:K06213	-	-	-	-	ko00000,ko02000	1.A.26.1	-	-	CBS,MgtE_N,PRC
HKD2_k127_3951125_13	326424.FRAAL6699	7.604e-41	169.0	COG0561@1|root,COG0561@2|Bacteria,2IRCG@201174|Actinobacteria,4EUX0@85013|Frankiales	201174|Actinobacteria	S	Haloacid dehalogenase domain protein hydrolase, type 3	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_3
HKD2_k127_3951125_7	330214.NIDE3393	4.651e-63	229.0	COG1085@1|root,COG1085@2|Bacteria,3J0ER@40117|Nitrospirae	40117|Nitrospirae	H	Galactose-1-phosphate uridyl transferase, N-terminal domain	galT	-	2.7.7.12	ko:K00965	ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917	M00362,M00554,M00632	R00955	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	GalP_UDP_tr_C,GalP_UDP_transf
HKD2_k127_3951125_18	1282876.BAOK01000002_gene294	2.35e-10	69.0	COG0454@1|root,COG0456@2|Bacteria,1RDWU@1224|Proteobacteria,2U7KM@28211|Alphaproteobacteria,4BSMP@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HKD2_k127_3951125_9	292459.STH2518	4.619e-48	185.0	COG0715@1|root,COG0715@2|Bacteria,1UY07@1239|Firmicutes,24EN3@186801|Clostridia	186801|Clostridia	P	ABC-type nitrate sulfonate bicarbonate transport	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
HKD2_k127_3951125_17	926569.ANT_29600	3.892e-11	69.0	COG0695@1|root,COG1225@1|root,COG0695@2|Bacteria,COG1225@2|Bacteria,2G6XD@200795|Chloroflexi	200795|Chloroflexi	O	Redoxin	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
HKD2_k127_3951125_8	479434.Sthe_1371	1.221e-58	216.0	COG0639@1|root,COG0639@2|Bacteria	2|Bacteria	T	phosphoprotein phosphatase activity	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos_2
HKD2_k127_3951125_6	1379698.RBG1_1C00001G0533	4.594e-78	276.0	COG0454@1|root,COG0456@2|Bacteria,2NNUP@2323|unclassified Bacteria	2|Bacteria	K	acetyltransferase	yghO	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HKD2_k127_3951125_10	1157638.KB892202_gene1920	1.586e-47	179.0	COG1926@1|root,COG1926@2|Bacteria,2GJUU@201174|Actinobacteria	201174|Actinobacteria	Q	phosphoribosyltransferase	-	-	-	ko:K07100	-	-	-	-	ko00000	-	-	-	DLH,Pribosyltran
HKD2_k127_3951125_5	1448389.BAVQ01000002_gene2914	3.801e-87	305.0	COG0515@1|root,COG2815@1|root,COG0515@2|Bacteria,COG2815@2|Bacteria,2GJ1J@201174|Actinobacteria	201174|Actinobacteria	KLT	serine threonine protein kinase	pknB	GO:0000270,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0006022,GO:0006023,GO:0006024,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008047,GO:0008150,GO:0008152,GO:0008360,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009605,GO:0009607,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0010698,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0022603,GO:0022604,GO:0030145,GO:0030203,GO:0030234,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032091,GO:0034645,GO:0036211,GO:0040007,GO:0042304,GO:0042546,GO:0042802,GO:0043085,GO:0043086,GO:0043167,GO:0043169,GO:0043170,GO:0043207,GO:0043388,GO:0043393,GO:0043412,GO:0044036,GO:0044038,GO:0044085,GO:0044092,GO:0044093,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044403,GO:0044419,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046777,GO:0046872,GO:0046890,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0050896,GO:0051055,GO:0051098,GO:0051099,GO:0051100,GO:0051101,GO:0051128,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0062012,GO:0062014,GO:0065007,GO:0065008,GO:0065009,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0075136,GO:0080090,GO:0098772,GO:0140096,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
HKD2_k127_3980121_43	1123304.AQYA01000017_gene20	0.0004688	46.0	2EG8N@1|root,33A0G@2|Bacteria,1VMHK@1239|Firmicutes,4HSIH@91061|Bacilli	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3980121_26	2423.NA23_0204940	1.591e-43	162.0	COG0432@1|root,COG0432@2|Bacteria,2GD2P@200918|Thermotogae	200918|Thermotogae	S	PFAM Uncharacterised protein family UPF0047	-	-	-	-	-	-	-	-	-	-	-	-	UPF0047
HKD2_k127_3980121_27	1206726.BAFV01000029_gene2129	3.053e-39	151.0	COG1259@1|root,COG1259@2|Bacteria,2GN26@201174|Actinobacteria,4FVJ2@85025|Nocardiaceae	201174|Actinobacteria	S	Bifunctional nuclease	-	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	ko:K08999	-	-	-	-	ko00000	-	-	-	DNase-RNase
HKD2_k127_3980121_15	593750.Metfor_2563	1.89e-73	257.0	COG0655@1|root,arCOG02573@2157|Archaea,2XWPJ@28890|Euryarchaeota,2NAHI@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
HKD2_k127_3980121_11	1048339.KB913029_gene2313	3.334e-93	320.0	COG0577@1|root,COG0577@2|Bacteria,2GIRW@201174|Actinobacteria,4EUUS@85013|Frankiales	201174|Actinobacteria	V	MacB-like periplasmic core domain	yknZ	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HKD2_k127_3980121_14	292459.STH976	1.447e-81	283.0	COG1136@1|root,COG1136@2|Bacteria,1TPBJ@1239|Firmicutes,248EZ@186801|Clostridia	186801|Clostridia	V	ABC transporter	macB	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD2_k127_3980121_40	743721.Psesu_1375	3.55e-10	72.0	COG0845@1|root,COG0845@2|Bacteria,1MX0G@1224|Proteobacteria,1RN0S@1236|Gammaproteobacteria,1X433@135614|Xanthomonadales	135614|Xanthomonadales	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	HlyD_D23
HKD2_k127_3980121_24	502558.EGYY_06890	1.517e-47	183.0	COG0546@1|root,COG0546@2|Bacteria,2I9FC@201174|Actinobacteria,4CVWZ@84998|Coriobacteriia	84998|Coriobacteriia	S	IA, variant 3	-	-	3.6.1.1	ko:K06019	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	HAD_2
HKD2_k127_3980121_28	304371.MCP_2646	5.906e-39	162.0	COG0477@1|root,arCOG00132@2157|Archaea,2XYHV@28890|Euryarchaeota	28890|Euryarchaeota	G	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
HKD2_k127_3980121_0	1235794.C811_01923	0.0	1120.0	COG0188@1|root,COG0188@2|Bacteria,2GJ2Q@201174|Actinobacteria,4CU8E@84998|Coriobacteriia	84998|Coriobacteriia	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
HKD2_k127_3980121_1	1408422.JHYF01000006_gene1012	4.21e-260	815.0	COG0187@1|root,COG0187@2|Bacteria,1TQ0R@1239|Firmicutes,248AV@186801|Clostridia,36DYE@31979|Clostridiaceae	186801|Clostridia	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
HKD2_k127_3980121_42	1121382.JQKG01000025_gene2984	0.0004258	52.0	COG5512@1|root,COG5512@2|Bacteria,1WIYS@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Protein of unknown function (DUF721)	-	-	-	-	-	-	-	-	-	-	-	-	DUF721
HKD2_k127_3980121_10	445975.COLSTE_02205	8.815e-95	323.0	COG1195@1|root,COG1195@2|Bacteria,2GJCS@201174|Actinobacteria,4CUNC@84998|Coriobacteriia	84998|Coriobacteriia	L	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP	recF	-	-	ko:K03629	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	SMC_N
HKD2_k127_3980121_12	1235794.C811_01926	2.78e-89	308.0	COG0592@1|root,COG0592@2|Bacteria,2GJK3@201174|Actinobacteria,4CUF2@84998|Coriobacteriia	84998|Coriobacteriia	L	Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria	dnaN	-	2.7.7.7	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3
HKD2_k127_3980121_5	997346.HMPREF9374_2517	1.517e-142	466.0	COG0593@1|root,COG0593@2|Bacteria,1TPV7@1239|Firmicutes,4H9MW@91061|Bacilli,27BH0@186824|Thermoactinomycetaceae	91061|Bacilli	L	Bacterial dnaA protein helix-turn-helix domain	dnaA	GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0034641,GO:0034645,GO:0042802,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901576,GO:1990837	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA,Bac_DnaA_C,DnaA_N
HKD2_k127_3980121_19	742818.HMPREF9451_01633	1.551e-57	211.0	COG1846@1|root,COG2172@1|root,COG1846@2|Bacteria,COG2172@2|Bacteria,2I4BY@201174|Actinobacteria,4CYKP@84998|Coriobacteriia	84998|Coriobacteriia	KT	PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c
HKD2_k127_3980121_38	1120933.ATUY01000010_gene1553	3.361e-14	77.0	COG0230@1|root,COG0230@2|Bacteria,2GQFY@201174|Actinobacteria,4D6Q0@85005|Actinomycetales	201174|Actinobacteria	J	Belongs to the bacterial ribosomal protein bL34 family	rpmH	-	-	ko:K02914	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L34
HKD2_k127_3980121_39	936550.HMPREF1492_1383	1.429e-12	72.0	COG0594@1|root,COG0594@2|Bacteria,2GR42@201174|Actinobacteria	201174|Actinobacteria	J	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme	rnpA	GO:0008150,GO:0040007	3.1.26.5	ko:K03536	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Ribonuclease_P
HKD2_k127_3980121_33	118166.JH976537_gene2762	1.782e-26	113.0	COG0759@1|root,COG0759@2|Bacteria,1G90B@1117|Cyanobacteria,1HCVK@1150|Oscillatoriales	1117|Cyanobacteria	S	Could be involved in insertion of integral membrane proteins into the membrane	-	-	-	ko:K08998	-	-	-	-	ko00000	-	-	-	Haemolytic
HKD2_k127_3980121_25	469378.Ccur_14180	1.404e-44	173.0	COG0706@1|root,COG0706@2|Bacteria,2GJBU@201174|Actinobacteria,4CUFT@84998|Coriobacteriia	84998|Coriobacteriia	U	Membrane protein insertase, YidC Oxa1 family	-	-	-	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03029	2.A.9	-	-	60KD_IMP
HKD2_k127_3980121_20	502558.EGYY_30310	6.348e-57	207.0	COG1847@1|root,COG1847@2|Bacteria,2GPZK@201174|Actinobacteria,4CUJI@84998|Coriobacteriia	84998|Coriobacteriia	S	R3H domain	-	-	-	ko:K06346	-	-	-	-	ko00000	-	-	-	KH_4,R3H
HKD2_k127_3980121_31	742818.HMPREF9451_01628	2.849e-33	138.0	COG0357@1|root,COG0357@2|Bacteria,2HUVU@201174|Actinobacteria,4CVTN@84998|Coriobacteriia	84998|Coriobacteriia	J	Specifically methylates the N7 position of a guanine in 16S rRNA	rsmG	-	2.1.1.170	ko:K03501	-	-	-	-	ko00000,ko01000,ko03009,ko03036	-	-	-	GidB
HKD2_k127_3980121_8	742722.HMPREF9463_00019	4.25e-102	339.0	COG1192@1|root,COG1192@2|Bacteria,2GMU7@201174|Actinobacteria,4CUR3@84998|Coriobacteriia	84998|Coriobacteriia	D	CobQ CobB MinD ParA nucleotide binding domain	soj	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
HKD2_k127_3980121_13	1384484.AEQU_0009	1.394e-81	280.0	COG1475@1|root,COG1475@2|Bacteria,2GNRN@201174|Actinobacteria,4CUFM@84998|Coriobacteriia	84998|Coriobacteriia	K	Belongs to the ParB family	-	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
HKD2_k127_3980121_44	1168034.FH5T_03920	0.0007585	46.0	COG4980@1|root,COG4980@2|Bacteria	2|Bacteria	D	gas vesicle protein	XK27_07760	-	-	-	-	-	-	-	-	-	-	-	YtxH
HKD2_k127_3980121_21	469383.Cwoe_1804	6.81e-53	214.0	COG3857@1|root,COG3857@2|Bacteria,2HNUC@201174|Actinobacteria,4CQ2I@84995|Rubrobacteria	84995|Rubrobacteria	L	PD-(D/E)XK nuclease superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_1
HKD2_k127_3980121_6	1380390.JIAT01000014_gene6206	2.06e-131	461.0	COG1074@1|root,COG1074@2|Bacteria,2GNKH@201174|Actinobacteria,4CPD7@84995|Rubrobacteria	84995|Rubrobacteria	L	PD-(D/E)XK nuclease superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
HKD2_k127_3980121_7	1111135.HMPREF1248_1254	1.452e-119	393.0	COG0820@1|root,COG0820@2|Bacteria,2GJ48@201174|Actinobacteria,4CUGN@84998|Coriobacteriia	84998|Coriobacteriia	J	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs	rlmN	-	2.1.1.192	ko:K06941	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Radical_SAM
HKD2_k127_3980121_23	742818.HMPREF9451_01624	7.115e-49	181.0	COG1592@1|root,COG1592@2|Bacteria,2I8N0@201174|Actinobacteria	201174|Actinobacteria	C	Rubrerythrin	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
HKD2_k127_3980121_17	358220.C380_19490	9.513e-64	235.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2VI4Q@28216|Betaproteobacteria,4A9SZ@80864|Comamonadaceae	28216|Betaproteobacteria	O	Belongs to the peptidase S1C family	mucD	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
HKD2_k127_3980121_9	502558.EGYY_30010	8.615e-98	329.0	COG1181@1|root,COG1181@2|Bacteria,2GRWM@201174|Actinobacteria,4CU9A@84998|Coriobacteriia	84998|Coriobacteriia	F	Belongs to the D-alanine--D-alanine ligase family	ddl	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C,Dala_Dala_lig_N
HKD2_k127_3980121_29	1385518.N798_00035	7.61e-37	158.0	COG0642@1|root,COG2205@2|Bacteria,2GIV9@201174|Actinobacteria,4FFK1@85021|Intrasporangiaceae	201174|Actinobacteria	T	Histidine kinase	phoR	-	2.7.13.3	ko:K02484	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
HKD2_k127_3980121_2	373903.Hore_21960	1.623e-222	722.0	COG0474@1|root,COG0474@2|Bacteria,1TPF5@1239|Firmicutes,247JN@186801|Clostridia,3WB3A@53433|Halanaerobiales	186801|Clostridia	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
HKD2_k127_3980121_16	379066.GAU_0830	8.745e-67	238.0	COG1760@1|root,COG1760@2|Bacteria,1ZT3U@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Serine dehydratase alpha chain	-	-	4.3.1.17	ko:K01752	ko00260,ko00270,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00270,map01100,map01110,map01130,map01200,map01230	-	R00220,R00590	RC00331,RC02600	ko00000,ko00001,ko01000	-	-	-	SDH_alpha
HKD2_k127_3980121_37	1123288.SOV_2c00770	4.614e-17	84.0	COG1918@1|root,COG1918@2|Bacteria,1VEQU@1239|Firmicutes,4H5YJ@909932|Negativicutes	909932|Negativicutes	P	FeoA	-	-	-	-	-	-	-	-	-	-	-	-	FeoA
HKD2_k127_3980121_4	1449126.JQKL01000017_gene2750	1.779e-207	661.0	COG0370@1|root,COG0370@2|Bacteria,1TP7E@1239|Firmicutes,24885@186801|Clostridia,2684P@186813|unclassified Clostridiales	186801|Clostridia	P	transporter of a GTP-driven Fe(2 ) uptake system	feoB	-	-	ko:K04759	-	-	-	-	ko00000,ko02000	9.A.8.1	-	-	FeoA,FeoB_C,FeoB_N,Gate
HKD2_k127_3980121_18	646529.Desaci_3670	1.411e-62	224.0	COG1760@1|root,COG1760@2|Bacteria,1U8TZ@1239|Firmicutes,24AEE@186801|Clostridia,261NW@186807|Peptococcaceae	186801|Clostridia	E	TIGRFAM L-serine dehydratase, iron-sulfur-dependent, beta subunit	sdaAB	-	4.3.1.17	ko:K01752	ko00260,ko00270,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00270,map01100,map01110,map01130,map01200,map01230	-	R00220,R00590	RC00331,RC02600	ko00000,ko00001,ko01000	-	-	-	ACT,SDH_beta
HKD2_k127_3980121_3	521003.COLINT_03263	8.65e-216	705.0	COG1199@1|root,COG2176@1|root,COG1199@2|Bacteria,COG2176@2|Bacteria,2GKT8@201174|Actinobacteria,4CUMF@84998|Coriobacteriia	84998|Coriobacteriia	L	DnaQ family exonuclease DinG family helicase	-	-	3.6.4.12	ko:K03722	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	Helicase_C_2,RNase_T
HKD2_k127_3980121_36	1123023.JIAI01000016_gene3441	1.926e-18	96.0	COG2378@1|root,COG2378@2|Bacteria,2GMAU@201174|Actinobacteria,4DY44@85010|Pseudonocardiales	201174|Actinobacteria	K	overlaps another CDS with the same product name	pafC	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	-	ko:K13573	-	-	-	-	ko00000,ko03051	-	-	-	WYL
HKD2_k127_3980121_34	1435356.Y013_04115	1.156e-25	125.0	COG2378@1|root,COG2378@2|Bacteria,2GM46@201174|Actinobacteria,4FX9I@85025|Nocardiaceae	201174|Actinobacteria	K	WYL domain	pafB	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	ko:K13572,ko:K13573	-	-	-	-	ko00000,ko03051	-	-	-	WYL
HKD2_k127_3980121_30	215803.DB30_3984	7.486e-36	154.0	COG0642@1|root,COG5002@1|root,COG2205@2|Bacteria,COG5002@2|Bacteria,1QX6W@1224|Proteobacteria,42ZK5@68525|delta/epsilon subdivisions,2WUSH@28221|Deltaproteobacteria,2YXKX@29|Myxococcales	28221|Deltaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_4
HKD2_k127_3980121_41	485913.Krac_11890	5.266e-09	66.0	2A1JS@1|root,30PTP@2|Bacteria,2G9H1@200795|Chloroflexi	200795|Chloroflexi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3980121_35	1121405.dsmv_1536	3.406e-25	115.0	COG0664@1|root,COG0664@2|Bacteria,1MZZD@1224|Proteobacteria,42QUX@68525|delta/epsilon subdivisions,2WMWV@28221|Deltaproteobacteria,2MJH7@213118|Desulfobacterales	28221|Deltaproteobacteria	K	cyclic nucleotide-binding	fnr-1	-	-	ko:K01420,ko:K21563	-	-	-	-	ko00000,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
HKD2_k127_3980121_22	1121430.JMLG01000008_gene1538	3.815e-49	190.0	COG1149@1|root,COG1149@2|Bacteria,1VUEG@1239|Firmicutes,2503A@186801|Clostridia,267CF@186807|Peptococcaceae	186801|Clostridia	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_21,Fer4_6
HKD2_k127_401030_8	1120972.AUMH01000011_gene207	1.814e-43	162.0	COG2201@1|root,COG2201@2|Bacteria,1V3IU@1239|Firmicutes,4HGY2@91061|Bacilli,279U5@186823|Alicyclobacillaceae	91061|Bacilli	T	cheY-homologous receiver domain	cheY	-	-	ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	Response_reg
HKD2_k127_401030_5	1343739.PAP_04525	4.149e-82	286.0	COG2201@1|root,arCOG02382@2157|Archaea,2XUKR@28890|Euryarchaeota,2433H@183968|Thermococci	183968|Thermococci	N	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR	cheB	-	3.1.1.61,3.5.1.44	ko:K03412	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest,Response_reg
HKD2_k127_401030_1	1408423.JHYA01000011_gene1298	1.043e-137	461.0	COG0643@1|root,COG2198@1|root,COG0643@2|Bacteria,COG2198@2|Bacteria,1TPMS@1239|Firmicutes,4H3AN@909932|Negativicutes	909932|Negativicutes	NT	Chemotaxis protein CheA	cheA	-	2.7.13.3	ko:K03407	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt,P2
HKD2_k127_401030_13	888060.HMPREF9081_2304	4.274e-39	155.0	COG1776@1|root,COG1776@2|Bacteria,1UNKB@1239|Firmicutes,4H25I@909932|Negativicutes	909932|Negativicutes	NT	Chemotaxis protein CheC	cheC	-	-	ko:K03410	ko02030,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheC
HKD2_k127_401030_14	1009370.ALO_14207	5.361e-32	130.0	COG1871@1|root,COG1871@2|Bacteria,1V70X@1239|Firmicutes,4H415@909932|Negativicutes	909932|Negativicutes	NT	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis	cheD	-	3.5.1.44	ko:K03411	ko02030,map02030	-	-	-	ko00000,ko00001,ko01000,ko02035	-	-	-	CheD
HKD2_k127_401030_7	243231.GSU1870	8.647e-52	202.0	COG2199@1|root,COG2203@1|root,COG2203@2|Bacteria,COG3706@2|Bacteria,1NECV@1224|Proteobacteria,42PZK@68525|delta/epsilon subdivisions,2WMIG@28221|Deltaproteobacteria,43W33@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,GGDEF
HKD2_k127_401030_10	479437.Elen_0581	2.99e-42	166.0	COG3409@1|root,COG3409@2|Bacteria,2HUI4@201174|Actinobacteria,4CUSS@84998|Coriobacteriia	84998|Coriobacteriia	M	Peptidoglycan binding domain	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_1
HKD2_k127_401030_11	1443125.Z962_12705	2.298e-40	166.0	COG0791@1|root,COG3883@1|root,COG0791@2|Bacteria,COG3883@2|Bacteria,1UVYK@1239|Firmicutes,249G6@186801|Clostridia,36FW2@31979|Clostridiaceae	186801|Clostridia	M	NLP P60 protein	-	-	-	ko:K21471	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	NLPC_P60,SH3_3
HKD2_k127_401030_3	671143.DAMO_1327	3.621e-122	403.0	COG2805@1|root,COG2805@2|Bacteria,2NP0T@2323|unclassified Bacteria	2|Bacteria	NU	Type II/IV secretion system protein	pilT	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
HKD2_k127_401030_0	443144.GM21_3533	2.02e-172	554.0	COG1032@1|root,COG1032@2|Bacteria,1MWR0@1224|Proteobacteria,42ZYI@68525|delta/epsilon subdivisions,2WVGV@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	SMART Elongator protein 3 MiaB NifB	-	-	1.21.98.3	ko:K04034	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R06268,R06269,R06270	RC00741,RC01491,RC01492	ko00000,ko00001,ko01000	-	-	-	B12-binding,Radical_SAM
HKD2_k127_401030_16	1384484.AEQU_0091	4.375e-18	91.0	COG5652@1|root,COG5652@2|Bacteria,2HV8T@201174|Actinobacteria,4CWHF@84998|Coriobacteriia	84998|Coriobacteriia	S	VanZ like family	-	-	-	-	-	-	-	-	-	-	-	-	VanZ
HKD2_k127_401030_15	1196029.ALIM01000049_gene4744	2.986e-26	120.0	COG0697@1|root,COG0697@2|Bacteria,1V3QH@1239|Firmicutes,4HDBZ@91061|Bacilli,1ZCM6@1386|Bacillus	91061|Bacilli	EG	COG0697 Permeases of the drug metabolite transporter (DMT) superfamily	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HKD2_k127_401030_2	266117.Rxyl_2308	8.957e-131	443.0	COG0744@1|root,COG0744@2|Bacteria,2GK21@201174|Actinobacteria,4CPUU@84995|Rubrobacteria	84995|Rubrobacteria	M	glycosyl transferase, family 51	-	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase
HKD2_k127_401030_4	1041930.Mtc_1380	6.083e-92	317.0	COG2006@1|root,arCOG02447@2157|Archaea,2XW1U@28890|Euryarchaeota,2N9D9@224756|Methanomicrobia	224756|Methanomicrobia	C	4Fe-4S ferredoxin, iron-sulfur binding	-	-	-	-	-	-	-	-	-	-	-	-	DUF362,Fer4,Fer4_7
HKD2_k127_401030_6	351607.Acel_1872	5.442e-56	213.0	COG0840@1|root,COG0840@2|Bacteria,2IA80@201174|Actinobacteria	201174|Actinobacteria	NT	chemotaxis	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CHASE3,MCPsignal
HKD2_k127_401030_12	1043493.BBLU01000017_gene1376	3.06e-40	153.0	COG0251@1|root,COG0251@2|Bacteria,2IHNE@201174|Actinobacteria	201174|Actinobacteria	J	endoribonuclease L-PSP	yabJ	-	-	-	-	-	-	-	-	-	-	-	YjgF_endoribonc
HKD2_k127_401030_9	246194.CHY_0604	3.365e-43	180.0	COG3005@1|root,COG3005@2|Bacteria,1VBE7@1239|Firmicutes,2527F@186801|Clostridia	186801|Clostridia	C	NapC/NirT cytochrome c family, N-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4065125_0	555088.DealDRAFT_1878	2.655e-152	492.0	COG0365@1|root,COG0365@2|Bacteria,1TQTI@1239|Firmicutes	1239|Firmicutes	I	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	acsA	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
HKD2_k127_4065125_3	1423321.AS29_06650	1.832e-50	191.0	COG1307@1|root,COG1307@2|Bacteria,1TRZ4@1239|Firmicutes,4HBR8@91061|Bacilli,1ZCJP@1386|Bacillus	91061|Bacilli	S	protein conserved in bacteria	degV	-	-	-	-	-	-	-	-	-	-	-	DegV
HKD2_k127_4065125_4	742818.HMPREF9451_00731	4.576e-35	143.0	COG0537@1|root,COG0537@2|Bacteria,2IHPT@201174|Actinobacteria,4CW18@84998|Coriobacteriia	84998|Coriobacteriia	FG	Histidine triad domain protein	-	-	-	ko:K02503	-	-	-	-	ko00000,ko04147	-	-	-	HIT
HKD2_k127_4065125_5	1210884.HG799462_gene8727	1.338e-13	74.0	COG1722@1|root,COG1722@2|Bacteria,2J1CM@203682|Planctomycetes	203682|Planctomycetes	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseB	-	3.1.11.6	ko:K03602	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_S
HKD2_k127_4065125_1	502558.EGYY_13110	5.777e-121	402.0	COG1570@1|root,COG1570@2|Bacteria,2GJAS@201174|Actinobacteria,4CUPF@84998|Coriobacteriia	84998|Coriobacteriia	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseA	-	3.1.11.6	ko:K03601	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_L,tRNA_anti_2
HKD2_k127_4065125_2	1267535.KB906767_gene3388	6.17e-111	373.0	COG0514@1|root,COG0514@2|Bacteria,3Y2KM@57723|Acidobacteria,2JP19@204432|Acidobacteriia	204432|Acidobacteriia	L	RecQ zinc-binding	-	-	3.6.4.12	ko:K03654	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,HRDC,Helicase_C,RecQ_Zn_bind
HKD2_k127_4077086_0	643473.KB235930_gene3501	5.102e-70	246.0	COG0451@1|root,COG0451@2|Bacteria,1G3BV@1117|Cyanobacteria,1HQKM@1161|Nostocales	1117|Cyanobacteria	GM	RmlD substrate binding domain	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
HKD2_k127_4077086_1	643473.KB235930_gene3500	1.154e-51	198.0	COG0438@1|root,COG0438@2|Bacteria,1G2K5@1117|Cyanobacteria	1117|Cyanobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_1
HKD2_k127_4077086_3	1127692.HMPREF9075_02352	9.807e-13	81.0	COG3594@1|root,COG3594@2|Bacteria,4NYWW@976|Bacteroidetes,1IBZ2@117743|Flavobacteriia,1EQMF@1016|Capnocytophaga	976|Bacteroidetes	G	Acyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
HKD2_k127_4077086_2	497964.CfE428DRAFT_3082	3.786e-46	192.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_1
HKD2_k127_423417_5	765420.OSCT_1557	1.959e-76	269.0	COG1079@1|root,COG1079@2|Bacteria,2G6BT@200795|Chloroflexi,374T2@32061|Chloroflexia	32061|Chloroflexia	S	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
HKD2_k127_423417_3	926561.KB900623_gene1122	8.064e-85	293.0	COG4603@1|root,COG4603@2|Bacteria,1TP1F@1239|Firmicutes,2494C@186801|Clostridia,3WAFN@53433|Halanaerobiales	186801|Clostridia	U	PFAM Branched-chain amino acid transport system permease component	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
HKD2_k127_423417_0	235909.GK1284	9.528e-172	557.0	COG3845@1|root,COG3845@2|Bacteria,1UYQA@1239|Firmicutes,4HVSH@91061|Bacilli,1WE80@129337|Geobacillus	91061|Bacilli	S	ATPases associated with a variety of cellular activities	yufO	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
HKD2_k127_423417_4	1123274.KB899414_gene3746	1.157e-83	290.0	COG1744@1|root,COG1744@2|Bacteria	2|Bacteria	ET	ABC transporter substrate-binding protein PnrA-like	yufN	-	-	ko:K02058,ko:K07335	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	Bmp
HKD2_k127_423417_2	649764.HMPREF0762_00549	1.66e-94	331.0	COG4974@1|root,COG4974@2|Bacteria,2GNDP@201174|Actinobacteria,4CUWF@84998|Coriobacteriia	84998|Coriobacteriia	D	Belongs to the 'phage' integrase family. XerC subfamily	xerD	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
HKD2_k127_423417_6	469371.Tbis_1478	4.54e-26	121.0	COG0454@1|root,COG0456@2|Bacteria,2GK6K@201174|Actinobacteria,4E68V@85010|Pseudonocardiales	201174|Actinobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10
HKD2_k127_423417_1	1255043.TVNIR_3052	1.067e-157	507.0	COG0686@1|root,COG0686@2|Bacteria,1QTX1@1224|Proteobacteria,1T1JB@1236|Gammaproteobacteria,1WXVZ@135613|Chromatiales	135613|Chromatiales	C	Belongs to the AlaDH PNT family	-	-	1.4.1.1	ko:K00259	ko00250,ko00430,ko01100,map00250,map00430,map01100	-	R00396	RC00008	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
HKD2_k127_423417_7	1089553.Tph_c16140	2.244e-17	85.0	COG3502@1|root,COG3502@2|Bacteria,1TQW1@1239|Firmicutes,24952@186801|Clostridia,42F42@68295|Thermoanaerobacterales	186801|Clostridia	S	Protein of unknown function (DUF3866)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3866
HKD2_k127_4255174_0	266117.Rxyl_1489	1.038e-135	459.0	COG0206@1|root,COG0206@2|Bacteria,2GJWC@201174|Actinobacteria,4CP7W@84995|Rubrobacteria	84995|Rubrobacteria	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
HKD2_k127_4255174_12	1122921.KB898185_gene3930	1.759e-20	103.0	COG1376@1|root,COG1376@2|Bacteria,1V9XU@1239|Firmicutes,4HKDD@91061|Bacilli,26Y7D@186822|Paenibacillaceae	91061|Bacilli	S	ErfK YbiS YcfS YnhG family protein	ykuD	-	-	-	-	-	-	-	-	-	-	-	LysM,YkuD
HKD2_k127_4255174_11	502558.EGYY_09620	1.021e-26	122.0	COG1589@1|root,COG1589@2|Bacteria,2HUMN@201174|Actinobacteria,4CV4T@84998|Coriobacteriia	84998|Coriobacteriia	D	Cell division protein FtsQ	-	-	-	ko:K03589	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036	-	-	-	FtsQ,POTRA_1
HKD2_k127_4255174_10	1384484.AEQU_1420	1.365e-78	272.0	COG0812@1|root,COG0812@2|Bacteria,2GIV2@201174|Actinobacteria,4CUCU@84998|Coriobacteriia	84998|Coriobacteriia	M	Cell wall formation	murB_1	-	1.3.1.98	ko:K00075	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R03191,R03192	RC02639	ko00000,ko00001,ko01000,ko01011	-	-	-	FAD_binding_4,MurB_C
HKD2_k127_4255174_2	1121468.AUBR01000006_gene365	8.477e-128	424.0	COG0773@1|root,COG0773@2|Bacteria,1TQ5H@1239|Firmicutes,2484K@186801|Clostridia,42ERF@68295|Thermoanaerobacterales	186801|Clostridia	M	Belongs to the MurCDEF family	murC	-	6.3.2.8	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R03193	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
HKD2_k127_4255174_8	1121866.AUGK01000016_gene2182	9.862e-85	296.0	COG0707@1|root,COG0707@2|Bacteria,2GJEM@201174|Actinobacteria,4CUWJ@84998|Coriobacteriia	84998|Coriobacteriia	M	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)	murG	-	2.4.1.227	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	-	R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011	-	GT28	-	Glyco_tran_28_C,Glyco_transf_28
HKD2_k127_4255174_9	643648.Slip_0794	2.072e-83	292.0	COG0772@1|root,COG0772@2|Bacteria,1TPT7@1239|Firmicutes,24894@186801|Clostridia,42JMA@68298|Syntrophomonadaceae	186801|Clostridia	D	Belongs to the SEDS family	ftsW	-	-	ko:K03588	ko04112,map04112	-	-	-	ko00000,ko00001,ko02000,ko03036	2.A.103.1	-	-	FTSW_RODA_SPOVE
HKD2_k127_4255174_7	1384484.AEQU_1424	1.061e-102	350.0	COG0771@1|root,COG0771@2|Bacteria,2GJZA@201174|Actinobacteria,4CUT4@84998|Coriobacteriia	84998|Coriobacteriia	M	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)	murD	-	6.3.2.9	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R02783	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase_C,Mur_ligase_M
HKD2_k127_4255174_5	1384484.AEQU_1425	6.413e-107	357.0	COG0472@1|root,COG0472@2|Bacteria,2GNEH@201174|Actinobacteria,4CUYB@84998|Coriobacteriia	84998|Coriobacteriia	M	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan	mraY	-	2.7.8.13	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	-	R05629,R05630	RC00002,RC02753	ko00000,ko00001,ko01000,ko01011	9.B.146	-	-	Glycos_transf_4,MraY_sig1
HKD2_k127_4255174_6	1089553.Tph_c12600	8.213e-104	357.0	COG0770@1|root,COG0770@2|Bacteria,1VT78@1239|Firmicutes,25100@186801|Clostridia,42EWR@68295|Thermoanaerobacterales	186801|Clostridia	M	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein	murF	-	6.3.2.10	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	-	R04573,R04617	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
HKD2_k127_4255174_1	867903.ThesuDRAFT_01664	5.953e-134	442.0	COG0769@1|root,COG0769@2|Bacteria,1TPQE@1239|Firmicutes,248Q4@186801|Clostridia,3WCXE@538999|Clostridiales incertae sedis	186801|Clostridia	M	to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan	murE	-	6.3.2.13	ko:K01928	ko00300,ko00550,map00300,map00550	-	R02788	RC00064,RC00090	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
HKD2_k127_4255174_4	1232410.KI421421_gene3858	9.673e-116	394.0	COG0768@1|root,COG0768@2|Bacteria,1MUNY@1224|Proteobacteria,42M1T@68525|delta/epsilon subdivisions,2WK0W@28221|Deltaproteobacteria,43TBV@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	PASTA domain	ftsI	-	3.4.16.4	ko:K03587	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011,ko03036	-	-	-	PASTA,PBP_dimer,Transpeptidase
HKD2_k127_4255174_3	521003.COLINT_02139	3.189e-117	384.0	COG0275@1|root,COG0275@2|Bacteria,2GJGK@201174|Actinobacteria,4CUEV@84998|Coriobacteriia	84998|Coriobacteriia	J	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA	rsmH	-	2.1.1.199	ko:K03438	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltransf_5
HKD2_k127_4269808_0	886293.Sinac_1249	0.0	2441.0	COG3459@1|root,COG3459@2|Bacteria,2IYJ0@203682|Planctomycetes	203682|Planctomycetes	G	Putative glucoamylase	-	-	-	ko:K13688	-	-	-	-	ko00000,ko01000,ko01003	-	GH94,GT84	-	Glyco_hydro_36,Glyco_transf_36,Glycoamylase
HKD2_k127_4269808_3	55601.VANGNB10_cII0043c	1.31e-15	83.0	COG0607@1|root,COG0607@2|Bacteria,1RHVM@1224|Proteobacteria,1SD9C@1236|Gammaproteobacteria,1XXY0@135623|Vibrionales	135623|Vibrionales	M	COG0607 Rhodanese-related sulfurtransferase	pspE	-	-	ko:K03972	-	-	-	-	ko00000	-	-	-	Rhodanese
HKD2_k127_4269808_4	246194.CHY_1095	8.316e-09	59.0	COG0526@1|root,COG4232@1|root,COG0526@2|Bacteria,COG4232@2|Bacteria,1V7JP@1239|Firmicutes,25ET7@186801|Clostridia	186801|Clostridia	CO	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	-	-	-	ko:K06196	-	-	-	-	ko00000,ko02000	5.A.1.2	-	-	AhpC-TSA,Redoxin
HKD2_k127_4269808_2	237368.SCABRO_02148	2.772e-32	137.0	COG0347@1|root,COG0347@2|Bacteria,2IZZ9@203682|Planctomycetes	203682|Planctomycetes	K	Belongs to the P(II) protein family	-	-	-	ko:K04751,ko:K04752	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	P-II
HKD2_k127_4269808_1	635013.TherJR_0705	1.499e-181	587.0	COG0004@1|root,COG0004@2|Bacteria,1TQYG@1239|Firmicutes,247W1@186801|Clostridia,2615C@186807|Peptococcaceae	186801|Clostridia	P	TIGRFAM Ammonium transporter	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
HKD2_k127_4359435_10	1389489.O159_28440	7.947e-69	241.0	COG1216@1|root,COG1216@2|Bacteria,2I2FA@201174|Actinobacteria,4FMW6@85023|Microbacteriaceae	201174|Actinobacteria	S	Glycosyl transferase family 2	ppm1	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2
HKD2_k127_4359435_2	469378.Ccur_12310	1.204e-180	574.0	COG0001@1|root,COG0001@2|Bacteria,2GJSH@201174|Actinobacteria,4CVGS@84998|Coriobacteriia	84998|Coriobacteriia	H	PFAM aminotransferase class-III	hemL	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
HKD2_k127_4359435_7	272562.CA_C2335	1.3e-86	295.0	COG1210@1|root,COG1210@2|Bacteria,1TQ24@1239|Firmicutes,25E5A@186801|Clostridia,36EIH@31979|Clostridiaceae	186801|Clostridia	M	UTP-glucose-1-phosphate uridylyltransferase	galU	-	2.7.7.9	ko:K00963	ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130	M00129,M00361,M00362,M00549	R00289	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
HKD2_k127_4359435_6	1123377.AUIV01000012_gene711	1.117e-115	384.0	COG1208@1|root,COG1208@2|Bacteria,1MUYJ@1224|Proteobacteria,1RNWP@1236|Gammaproteobacteria,1X5VT@135614|Xanthomonadales	135614|Xanthomonadales	JM	Glucose-1-phosphate cytidylyltransferase	-	-	2.7.7.33	ko:K00978	ko00500,ko00520,ko01100,map00500,map00520,map01100	-	R00956	RC00002	ko00000,ko00001,ko01000	-	-	-	NTP_transferase
HKD2_k127_4359435_5	1123274.KB899438_gene665	1.831e-117	394.0	COG0451@1|root,COG0451@2|Bacteria,2J5M2@203691|Spirochaetes	203691|Spirochaetes	M	CDP-glucose 4,6-dehydratase	rfbG	-	4.2.1.45	ko:K01709	ko00520,map00520	-	R02426	RC00402	ko00000,ko00001,ko01000	-	-	-	GDP_Man_Dehyd
HKD2_k127_4359435_1	316067.Geob_2126	3.429e-181	595.0	COG0399@1|root,COG0399@2|Bacteria,1MUPN@1224|Proteobacteria,42MA3@68525|delta/epsilon subdivisions,2WM1D@28221|Deltaproteobacteria,43SU4@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	DegT/DnrJ/EryC1/StrS aminotransferase family	ddhC	-	1.17.1.1	ko:K12452	ko00520,map00520	-	R03391,R03392	RC00230	ko00000,ko00001,ko01000	-	-	-	DegT_DnrJ_EryC1
HKD2_k127_4359435_9	886293.Sinac_3928	7.854e-84	293.0	COG0451@1|root,COG0451@2|Bacteria	2|Bacteria	GM	ADP-glyceromanno-heptose 6-epimerase activity	-	-	4.2.1.46,5.1.3.2	ko:K01710,ko:K01784	ko00052,ko00520,ko00521,ko00523,ko00525,ko01055,ko01100,ko01130,map00052,map00520,map00521,map00523,map00525,map01055,map01100,map01130	M00361,M00362,M00632,M00793	R00291,R02984,R06513	RC00289,RC00402	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
HKD2_k127_4359435_3	748247.AZKH_1439	5.768e-178	577.0	COG0662@1|root,COG2089@1|root,COG0662@2|Bacteria,COG2089@2|Bacteria,1MWG3@1224|Proteobacteria,2VHMH@28216|Betaproteobacteria,2KWIU@206389|Rhodocyclales	206389|Rhodocyclales	M	NeuB family	-	-	2.5.1.56	ko:K01654	ko00520,ko01100,map00520,map01100	-	R01804,R04435	RC00159	ko00000,ko00001,ko01000	-	-	-	Cupin_2,NeuB
HKD2_k127_4359435_0	903818.KI912268_gene2856	1.408e-214	689.0	COG0028@1|root,COG0028@2|Bacteria,3Y3TV@57723|Acidobacteria	57723|Acidobacteria	EH	Belongs to the TPP enzyme family	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
HKD2_k127_4359435_4	886293.Sinac_3929	2.527e-122	401.0	COG0463@1|root,COG0463@2|Bacteria,2IYUR@203682|Planctomycetes	203682|Planctomycetes	M	PFAM Glycosyl transferase family 2	-	-	-	ko:K20534	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.2.1.9	GT2	-	Glycos_transf_2
HKD2_k127_4359435_8	234267.Acid_2239	1.272e-85	299.0	COG1086@1|root,COG1086@2|Bacteria,3Y53V@57723|Acidobacteria	57723|Acidobacteria	GM	Methyltransferase FkbM domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_21
HKD2_k127_4370597_10	1121106.JQKB01000012_gene4682	1.517e-30	141.0	COG0265@1|root,COG0823@1|root,COG2931@1|root,COG0265@2|Bacteria,COG0823@2|Bacteria,COG2931@2|Bacteria	2|Bacteria	Q	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	ko:K08372	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	HemolysinCabind,NACHT,PDZ_2,Trypsin_2,VCBS
HKD2_k127_4370597_14	68170.KL590560_gene3999	1.235e-06	62.0	COG3055@1|root,COG3055@2|Bacteria,2IARJ@201174|Actinobacteria	201174|Actinobacteria	G	Belongs to the glycosyl hydrolase 43 family	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4370597_5	979556.MTES_0929	4.093e-54	210.0	COG0489@1|root,COG3944@1|root,COG0489@2|Bacteria,COG3944@2|Bacteria,2GJ1Y@201174|Actinobacteria,4FM6M@85023|Microbacteriaceae	201174|Actinobacteria	D	Chain length determinant protein	-	-	-	-	-	-	-	-	-	-	-	-	AAA_31,CbiA,ParA,Wzz
HKD2_k127_4370597_12	404380.Gbem_1791	2.681e-18	99.0	COG2244@1|root,COG2244@2|Bacteria,1RIXW@1224|Proteobacteria,42UIJ@68525|delta/epsilon subdivisions,2WQC5@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM Polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt,Polysacc_synt_3,Polysacc_synt_C
HKD2_k127_4370597_6	1280664.AUIX01000007_gene3340	1.835e-41	173.0	COG0438@1|root,COG0438@2|Bacteria,1UZ7J@1239|Firmicutes,24DZW@186801|Clostridia,4BX4Y@830|Butyrivibrio	186801|Clostridia	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glycos_transf_1
HKD2_k127_4370597_4	330214.NIDE2991	3.53e-63	239.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
HKD2_k127_4370597_7	1120917.AQXM01000056_gene707	4.729e-37	154.0	COG0148@1|root,COG0148@2|Bacteria,2GJAY@201174|Actinobacteria,1W828@1268|Micrococcaceae	201174|Actinobacteria	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
HKD2_k127_4370597_13	305700.B447_08853	7.341e-16	85.0	COG0406@1|root,COG0406@2|Bacteria,1NPC4@1224|Proteobacteria,2VQTE@28216|Betaproteobacteria,2KWHE@206389|Rhodocyclales	206389|Rhodocyclales	G	Belongs to the phosphoglycerate mutase family	gpmB	-	5.4.2.12	ko:K15634	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	His_Phos_1
HKD2_k127_4370597_8	1219076.N646_2408	7.138e-34	144.0	COG0189@1|root,COG0189@2|Bacteria,1NJD7@1224|Proteobacteria	1224|Proteobacteria	HJ	ligase activity	-	-	-	-	-	-	-	-	-	-	-	-	RimK
HKD2_k127_4370597_11	880073.Calab_0561	3.969e-29	133.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tran_WbsX,Glyco_trans_1_4,Glycos_transf_1
HKD2_k127_4370597_9	143224.JQMD01000002_gene3414	1.616e-33	143.0	COG0438@1|root,COG0438@2|Bacteria,4NPX0@976|Bacteroidetes	976|Bacteroidetes	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
HKD2_k127_4370597_1	867903.ThesuDRAFT_01819	5.526e-123	411.0	COG1004@1|root,COG1004@2|Bacteria,1TQFN@1239|Firmicutes,25B1W@186801|Clostridia	186801|Clostridia	M	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	-	-	1.1.1.22	ko:K00012	ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100	M00014,M00129,M00361,M00362	R00286	RC00291	ko00000,ko00001,ko00002,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
HKD2_k127_4370597_2	525904.Tter_2834	8.533e-98	331.0	COG0451@1|root,COG0451@2|Bacteria,2NNT0@2323|unclassified Bacteria	2|Bacteria	M	Polysaccharide biosynthesis protein	ytcB	-	5.1.3.2,5.1.3.6	ko:K01784,ko:K08679	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R01385,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
HKD2_k127_4370597_3	1125712.HMPREF1316_0163	8.744e-82	292.0	COG0285@1|root,COG0285@2|Bacteria,2GJP2@201174|Actinobacteria,4CUUQ@84998|Coriobacteriia	84998|Coriobacteriia	H	Bifunctional protein	folC	-	6.3.2.12,6.3.2.17	ko:K11754	ko00790,ko01100,map00790,map01100	M00126,M00841	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	Mur_ligase_C,Mur_ligase_M
HKD2_k127_4370597_0	502558.EGYY_18720	0.0	1030.0	COG0525@1|root,COG0525@2|Bacteria,2GK8H@201174|Actinobacteria,4CUW2@84998|Coriobacteriia	84998|Coriobacteriia	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
HKD2_k127_4374855_8	555088.DealDRAFT_1681	7.796e-05	47.0	COG1527@1|root,COG1527@2|Bacteria,1U6WZ@1239|Firmicutes,249XD@186801|Clostridia	186801|Clostridia	C	subunit c	ntpC	-	-	ko:K02119	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	vATP-synt_AC39
HKD2_k127_4374855_7	879305.HMPREF9290_0449	3.484e-07	56.0	COG1436@1|root,COG1436@2|Bacteria,1VAX7@1239|Firmicutes,24MXC@186801|Clostridia,22HNU@1570339|Peptoniphilaceae	186801|Clostridia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpF	-	-	ko:K02122	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_F
HKD2_k127_4374855_0	555079.Toce_2042	5.626e-244	767.0	COG1155@1|root,COG1155@2|Bacteria,1TPGS@1239|Firmicutes,24882@186801|Clostridia,42ETB@68295|Thermoanaerobacterales	186801|Clostridia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit	-	-	3.6.3.14,3.6.3.15	ko:K02117	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002,ko01000	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn
HKD2_k127_4374855_1	340099.Teth39_2258	1.163e-222	698.0	COG1156@1|root,COG1156@2|Bacteria,1VSU1@1239|Firmicutes,2496H@186801|Clostridia,42FIF@68295|Thermoanaerobacterales	186801|Clostridia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit	atpB	-	-	ko:K02118	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N
HKD2_k127_4374855_5	584708.Apau_1500	1.377e-49	184.0	COG1394@1|root,COG1394@2|Bacteria,3TA83@508458|Synergistetes	508458|Synergistetes	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpD	-	-	ko:K02120	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_D
HKD2_k127_4374855_3	1379698.RBG1_1C00001G1510	2.183e-75	277.0	COG0312@1|root,COG0312@2|Bacteria,2NP7I@2323|unclassified Bacteria	2|Bacteria	S	Putative modulator of DNA gyrase	tldE2	-	-	ko:K03592	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
HKD2_k127_4374855_2	515635.Dtur_0186	2.054e-158	515.0	COG0312@1|root,COG0312@2|Bacteria	2|Bacteria	S	metallopeptidase activity	tldD2	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
HKD2_k127_4374855_6	748727.CLJU_c01500	3.476e-42	173.0	COG0791@1|root,COG3883@1|root,COG0791@2|Bacteria,COG3883@2|Bacteria,1UVYK@1239|Firmicutes,249G6@186801|Clostridia,36FW2@31979|Clostridiaceae	186801|Clostridia	M	NLP P60 protein	-	-	-	ko:K21471	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	NLPC_P60,SH3_3
HKD2_k127_4374855_4	457429.ABJI02000597_gene257	8.484e-64	238.0	COG4585@1|root,COG4585@2|Bacteria,2GKV2@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
HKD2_k127_4565319_1	1041930.Mtc_2333	2.687e-55	196.0	COG1156@1|root,arCOG00865@2157|Archaea,2XSYQ@28890|Euryarchaeota,2NAB4@224756|Methanomicrobia	224756|Methanomicrobia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit	atpB-2	-	-	ko:K02118	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N
HKD2_k127_4565319_2	323259.Mhun_1757	1.093e-51	190.0	COG1394@1|root,arCOG04101@2157|Archaea	2157|Archaea	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpD	-	-	ko:K02120	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_D
HKD2_k127_4565319_3	1123373.ATXI01000024_gene116	1.564e-41	163.0	COG0778@1|root,COG0778@2|Bacteria,2GHHZ@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	C	Putative TM nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
HKD2_k127_4565319_0	1321773.HMPREF9069_00878	8.079e-60	221.0	COG1573@1|root,COG1573@2|Bacteria,2GMPT@201174|Actinobacteria,4CUM5@84998|Coriobacteriia	84998|Coriobacteriia	L	Uracil-DNA glycosylase, family 4	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
HKD2_k127_4642278_1	561175.KB894096_gene498	1.035e-188	614.0	COG1109@1|root,COG1208@1|root,COG1109@2|Bacteria,COG1208@2|Bacteria,2GKTE@201174|Actinobacteria,4EFSZ@85012|Streptosporangiales	201174|Actinobacteria	GJM	Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III	-	-	2.7.7.13,5.4.2.8	ko:K16881	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114,M00362	R00885,R01818	RC00002,RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase,PGM_PMM_I,PGM_PMM_II,PGM_PMM_III
HKD2_k127_4642278_26	525904.Tter_0345	2.234e-60	232.0	COG2720@1|root,COG2720@2|Bacteria,2NQB5@2323|unclassified Bacteria	2|Bacteria	V	VanW like protein	vanW	-	-	-	-	-	-	-	-	-	-	-	PG_binding_4,VanW
HKD2_k127_4642278_3	1449126.JQKL01000034_gene1279	1.396e-174	557.0	COG1541@1|root,COG1541@2|Bacteria,1TQA1@1239|Firmicutes,248G9@186801|Clostridia,26A76@186813|unclassified Clostridiales	186801|Clostridia	H	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)	paaK	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C_2
HKD2_k127_4642278_37	429009.Adeg_0167	2.031e-36	142.0	COG4747@1|root,COG4747@2|Bacteria,1V7U2@1239|Firmicutes,24JE5@186801|Clostridia,42GI5@68295|Thermoanaerobacterales	186801|Clostridia	S	PFAM amino acid-binding ACT domain protein	-	-	-	-	-	-	-	-	-	-	-	-	ACT
HKD2_k127_4642278_46	1122947.FR7_3381	3.705e-08	60.0	COG2165@1|root,COG2165@2|Bacteria,1VK8F@1239|Firmicutes,4H610@909932|Negativicutes	909932|Negativicutes	NU	Prepilin-type cleavage methylation N-terminal domain protein	-	-	-	ko:K02456	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl,T2SSG
HKD2_k127_4642278_23	1121335.Clst_1258	1.983e-67	246.0	COG1686@1|root,COG1686@2|Bacteria,1TQ8M@1239|Firmicutes,2480S@186801|Clostridia,3WGET@541000|Ruminococcaceae	186801|Clostridia	M	Belongs to the peptidase S11 family	dacB2	-	3.4.16.4	ko:K07258	ko00550,ko01100,map00550,map01100	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	PBP5_C,Peptidase_S11
HKD2_k127_4642278_13	1173020.Cha6605_4583	1.873e-90	324.0	COG0404@1|root,COG0404@2|Bacteria,1G0GR@1117|Cyanobacteria	1117|Cyanobacteria	E	The glycine cleavage system catalyzes the degradation of glycine	gcvT	-	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	GCV_T,GCV_T_C
HKD2_k127_4642278_32	1121017.AUFG01000005_gene986	1.822e-47	175.0	COG0509@1|root,COG0509@2|Bacteria,2IKN2@201174|Actinobacteria,4FGP8@85021|Intrasporangiaceae	201174|Actinobacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	gcvH	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	iNJ661.Rv1826	GCV_H
HKD2_k127_4642278_10	401526.TcarDRAFT_2681	1.617e-133	439.0	COG0403@1|root,COG0403@2|Bacteria,1TQGG@1239|Firmicutes,4H3B3@909932|Negativicutes	909932|Negativicutes	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPA	-	1.4.4.2	ko:K00282	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	-	GDC-P
HKD2_k127_4642278_2	562970.Btus_0711	2.774e-176	571.0	COG1003@1|root,COG1003@2|Bacteria,1TPK9@1239|Firmicutes,4HB80@91061|Bacilli,27881@186823|Alicyclobacillaceae	91061|Bacilli	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPB	-	1.4.4.2	ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	-	Aminotran_5,GDC-P
HKD2_k127_4642278_39	485913.Krac_8667	5.051e-36	151.0	COG0095@1|root,COG0095@2|Bacteria,2G6P9@200795|Chloroflexi	200795|Chloroflexi	H	PFAM Biotin lipoate A B protein ligase	-	-	6.3.1.20	ko:K03800	ko00785,ko01100,map00785,map01100	-	R07770,R07771,R11143	RC00043,RC00070,RC00090,RC00992,RC02896	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB
HKD2_k127_4642278_45	1283299.AUKG01000002_gene4958	1.218e-12	74.0	2AUU1@1|root,31KH5@2|Bacteria,2HPC3@201174|Actinobacteria,4CQQ6@84995|Rubrobacteria	84995|Rubrobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4642278_42	525909.Afer_1125	1.837e-27	119.0	COG1716@1|root,COG1716@2|Bacteria,2GK99@201174|Actinobacteria,4CN4F@84992|Acidimicrobiia	84992|Acidimicrobiia	T	Forkhead associated domain	-	-	-	-	-	-	-	-	-	-	-	-	Yop-YscD_cpl,zinc_ribbon_2
HKD2_k127_4642278_34	1504822.CCNO01000015_gene879	2.328e-44	169.0	COG0789@1|root,COG0789@2|Bacteria	2|Bacteria	K	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	MerR_1
HKD2_k127_4642278_36	234267.Acid_0127	4e-38	147.0	COG1102@1|root,COG1102@2|Bacteria	2|Bacteria	F	Psort location Cytoplasmic, score	-	-	2.4.2.8	ko:K00760	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	-	R00190,R01132,R01229,R02142,R08237,R08238,R08245	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	Cytidylate_kin2,GAF_2,Pribosyltran
HKD2_k127_4642278_29	671143.DAMO_2814	7.244e-56	201.0	COG0634@1|root,COG0634@2|Bacteria,2NPER@2323|unclassified Bacteria	2|Bacteria	F	Belongs to the purine pyrimidine phosphoribosyltransferase family	hpt	GO:0000287,GO:0003674,GO:0003824,GO:0004422,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006166,GO:0006177,GO:0006188,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032261,GO:0032263,GO:0032264,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0043094,GO:0043101,GO:0043167,GO:0043169,GO:0043173,GO:0043174,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046040,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.4.2.8	ko:K00760	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	-	R00190,R01132,R01229,R02142,R08237,R08238,R08245	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	Pribosyltran
HKD2_k127_4642278_18	37919.EP51_03950	2.446e-79	276.0	COG0490@1|root,COG1226@1|root,COG0490@2|Bacteria,COG1226@2|Bacteria,2GKB8@201174|Actinobacteria,4FY7G@85025|Nocardiaceae	201174|Actinobacteria	P	TrkA-N domain	-	-	-	ko:K10716	-	-	-	-	ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	Ion_trans_2,TrkA_C,TrkA_N
HKD2_k127_4642278_28	649764.HMPREF0762_01766	1.663e-56	203.0	COG0503@1|root,COG0503@2|Bacteria,2IM7C@201174|Actinobacteria,4CVSW@84998|Coriobacteriia	84998|Coriobacteriia	F	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis	apt	-	2.4.2.7	ko:K00759	ko00230,ko01100,map00230,map01100	-	R00190,R01229,R04378	RC00063	ko00000,ko00001,ko01000,ko04147	-	-	-	Pribosyltran
HKD2_k127_4642278_43	59374.Fisuc_1956	2.364e-21	105.0	COG0797@1|root,COG0797@2|Bacteria	2|Bacteria	M	peptidoglycan binding	rlpA	-	-	ko:K03642	-	-	-	-	ko00000	-	-	-	DPBB_1,SPOR
HKD2_k127_4642278_33	748727.CLJU_c01500	1.011e-45	179.0	COG0791@1|root,COG3883@1|root,COG0791@2|Bacteria,COG3883@2|Bacteria,1UVYK@1239|Firmicutes,249G6@186801|Clostridia,36FW2@31979|Clostridiaceae	186801|Clostridia	M	NLP P60 protein	-	-	-	ko:K21471	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	NLPC_P60,SH3_3
HKD2_k127_4642278_35	118166.JH976537_gene2000	1.691e-40	160.0	COG0668@1|root,COG0668@2|Bacteria,1G0CX@1117|Cyanobacteria,1H8K1@1150|Oscillatoriales	1117|Cyanobacteria	M	Mechanosensitive ion channel	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel
HKD2_k127_4642278_0	370438.PTH_2846	3.233e-197	637.0	COG4231@1|root,COG4231@2|Bacteria,1TNY3@1239|Firmicutes,247U1@186801|Clostridia,260MU@186807|Peptococcaceae	186801|Clostridia	C	Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates	iorA	-	1.2.7.8	ko:K00179	-	-	-	-	br01601,ko00000,ko01000	-	-	-	Fer4,POR_N,TPP_enzyme_C
HKD2_k127_4642278_27	1504822.CCNO01000014_gene1185	1.956e-57	209.0	COG1014@1|root,COG1014@2|Bacteria	2|Bacteria	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	iorB	-	1.2.7.8	ko:K00180	-	-	-	-	br01601,ko00000,ko01000	-	-	-	POR
HKD2_k127_4642278_41	747365.Thena_1452	5.01e-31	138.0	COG4747@1|root,COG4747@2|Bacteria,1V7U2@1239|Firmicutes,24JE5@186801|Clostridia,42GI5@68295|Thermoanaerobacterales	186801|Clostridia	S	PFAM amino acid-binding ACT domain protein	-	-	-	-	-	-	-	-	-	-	-	-	ACT
HKD2_k127_4642278_15	1121438.JNJA01000012_gene1545	9.294e-84	292.0	COG0683@1|root,COG0683@2|Bacteria,1MXR4@1224|Proteobacteria,42MXX@68525|delta/epsilon subdivisions,2WKJM@28221|Deltaproteobacteria,2M7W7@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	PFAM Extracellular ligand-binding receptor	livK-1	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	iAF987.Gmet_1823	Peripla_BP_6
HKD2_k127_4642278_17	596151.DesfrDRAFT_3304	1.452e-81	286.0	COG0683@1|root,COG0683@2|Bacteria,1MXR4@1224|Proteobacteria,42MXX@68525|delta/epsilon subdivisions,2WKJM@28221|Deltaproteobacteria,2M7W7@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	PFAM Extracellular ligand-binding receptor	livK-1	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	iAF987.Gmet_1823	Peripla_BP_6
HKD2_k127_4642278_20	404380.Gbem_2188	2.019e-74	261.0	COG0559@1|root,COG0559@2|Bacteria,1MU25@1224|Proteobacteria,42MKP@68525|delta/epsilon subdivisions,2WJU9@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	livH	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HKD2_k127_4642278_24	883.DvMF_1482	5.349e-67	241.0	COG4177@1|root,COG4177@2|Bacteria,1MV66@1224|Proteobacteria,42MAQ@68525|delta/epsilon subdivisions,2WKK0@28221|Deltaproteobacteria,2M91J@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HKD2_k127_4642278_19	1121422.AUMW01000006_gene711	6.541e-77	272.0	COG0411@1|root,COG0411@2|Bacteria,1TR0P@1239|Firmicutes,2490B@186801|Clostridia,260ZT@186807|Peptococcaceae	186801|Clostridia	E	ABC transporter	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
HKD2_k127_4642278_22	1121440.AUMA01000009_gene599	1.758e-73	256.0	COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,42M5A@68525|delta/epsilon subdivisions,2WK03@28221|Deltaproteobacteria,2M9W9@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	PFAM ABC transporter related	livF	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
HKD2_k127_4642278_4	502558.EGYY_13870	3.629e-174	556.0	COG1541@1|root,COG1541@2|Bacteria,2GJC7@201174|Actinobacteria,4CUCR@84998|Coriobacteriia	84998|Coriobacteriia	H	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)	-	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C_2
HKD2_k127_4642278_48	1118054.CAGW01000020_gene4202	9.408e-06	54.0	COG0860@1|root,COG3807@1|root,COG0860@2|Bacteria,COG3807@2|Bacteria,1UYPW@1239|Firmicutes,4HBVT@91061|Bacilli,26UYQ@186822|Paenibacillaceae	91061|Bacilli	MT	Ami_3	lytH	GO:0005575,GO:0005623,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	Amidase_3,SH3_3
HKD2_k127_4642278_47	323261.Noc_0462	1.575e-07	62.0	COG2149@1|root,COG2149@2|Bacteria	2|Bacteria	S	membrane	-	-	-	ko:K00389	-	-	-	-	ko00000	-	-	-	DUF202
HKD2_k127_4642278_6	521003.COLINT_02764	1.098e-152	495.0	COG2233@1|root,COG2233@2|Bacteria,2GMH6@201174|Actinobacteria,4CUI7@84998|Coriobacteriia	84998|Coriobacteriia	F	permease	-	-	-	-	-	-	-	-	-	-	-	-	Xan_ur_permease
HKD2_k127_4642278_9	742742.HMPREF9452_01213	2.063e-134	445.0	COG2252@1|root,COG2252@2|Bacteria,2GKYD@201174|Actinobacteria,4CUN6@84998|Coriobacteriia	84998|Coriobacteriia	S	permease	-	-	-	ko:K06901	-	-	-	-	ko00000,ko02000	2.A.1.40	-	-	Xan_ur_permease
HKD2_k127_4642278_44	572544.Ilyop_0684	7.316e-15	82.0	COG1051@1|root,COG1051@2|Bacteria,37ASE@32066|Fusobacteria	32066|Fusobacteria	F	Hydrolase, NUDIX family	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
HKD2_k127_4642278_31	700015.Corgl_0969	1.919e-52	199.0	COG0756@1|root,COG0756@2|Bacteria,2IHYY@201174|Actinobacteria,4CVRY@84998|Coriobacteriia	84998|Coriobacteriia	F	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA	dut	-	3.6.1.23	ko:K01520	ko00240,ko00983,ko01100,map00240,map00983,map01100	M00053	R02100,R11896	RC00002	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	dUTPase
HKD2_k127_4642278_40	1232410.KI421428_gene1013	2.163e-35	148.0	COG1180@1|root,COG1180@2|Bacteria,1NQC1@1224|Proteobacteria,42QX3@68525|delta/epsilon subdivisions,2WPC7@28221|Deltaproteobacteria,43SFR@69541|Desulfuromonadales	28221|Deltaproteobacteria	O	4Fe-4S single cluster domain	pflA	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
HKD2_k127_4642278_30	661087.HMPREF1008_01462	2.07e-55	197.0	COG1327@1|root,COG1327@2|Bacteria,2IHU9@201174|Actinobacteria,4CVYF@84998|Coriobacteriia	84998|Coriobacteriia	K	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes	nrdR	-	-	ko:K07738	-	-	-	-	ko00000,ko03000	-	-	-	ATP-cone
HKD2_k127_4642278_21	867903.ThesuDRAFT_00167	2.471e-74	257.0	COG1974@1|root,COG1974@2|Bacteria,1TQ3H@1239|Firmicutes,24AXJ@186801|Clostridia,3WCIP@538999|Clostridiales incertae sedis	186801|Clostridia	K	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair	lexA	-	3.4.21.88	ko:K01356	-	M00729	-	-	ko00000,ko00002,ko01000,ko01002,ko03400	-	-	-	LexA_DNA_bind,Peptidase_S24
HKD2_k127_4642278_7	479437.Elen_1612	3.357e-146	482.0	COG2262@1|root,COG2262@2|Bacteria,2GK55@201174|Actinobacteria,4CUJD@84998|Coriobacteriia	84998|Coriobacteriia	S	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis	hflX	-	-	ko:K03665	-	-	-	-	ko00000,ko03009	-	-	-	GTP-bdg_M,GTP-bdg_N,MMR_HSR1
HKD2_k127_4642278_8	477974.Daud_1603	3.358e-145	469.0	COG0436@1|root,COG0436@2|Bacteria,1TQD6@1239|Firmicutes,2491B@186801|Clostridia,260IS@186807|Peptococcaceae	186801|Clostridia	E	PFAM Aminotransferase class I and II	dapL	-	2.6.1.83	ko:K10206	ko00300,ko01100,ko01110,ko01130,ko01230,map00300,map01100,map01110,map01130,map01230	M00527	R07613	RC00006,RC01847	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
HKD2_k127_4642278_16	370438.PTH_1800	1.392e-81	283.0	COG0253@1|root,COG0253@2|Bacteria,1TPMN@1239|Firmicutes,24AGY@186801|Clostridia,260JZ@186807|Peptococcaceae	186801|Clostridia	E	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan	dapF	-	5.1.1.7	ko:K01778	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00527	R02735	RC00302	ko00000,ko00001,ko00002,ko01000	-	-	-	DAP_epimerase
HKD2_k127_4642278_12	1232436.CAPF01000014_gene775	7.142e-92	314.0	COG0324@1|root,COG0324@2|Bacteria,2GKFT@201174|Actinobacteria,4CV6N@84998|Coriobacteriia	84998|Coriobacteriia	F	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)	miaA	-	2.5.1.75	ko:K00791	ko00908,ko01100,ko01110,map00908,map01100,map01110	-	R01122	RC02820	ko00000,ko00001,ko01000,ko01006,ko03016	-	-	-	IPPT
HKD2_k127_4642278_11	635013.TherJR_0336	3.94e-112	384.0	COG2078@1|root,COG3885@1|root,COG2078@2|Bacteria,COG3885@2|Bacteria,1TQH8@1239|Firmicutes,2491Q@186801|Clostridia,26152@186807|Peptococcaceae	186801|Clostridia	S	pfam ammecr1	-	-	-	ko:K06990,ko:K09141	-	-	-	-	ko00000,ko04812	-	-	-	AMMECR1,LigB
HKD2_k127_4642278_5	1384484.AEQU_1056	4.863e-156	505.0	COG0621@1|root,COG0621@2|Bacteria,2GJEV@201174|Actinobacteria,4CUYE@84998|Coriobacteriia	84998|Coriobacteriia	J	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine	miaB	-	2.8.4.3	ko:K06168	-	-	R10645,R10646,R10647	RC00003,RC00980,RC03221,RC03222	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
HKD2_k127_4642278_25	370438.PTH_1307	1.562e-62	228.0	COG0613@1|root,COG0613@2|Bacteria,1TPI5@1239|Firmicutes,248H2@186801|Clostridia,26144@186807|Peptococcaceae	186801|Clostridia	S	PFAM PHP domain	-	-	3.1.3.97	ko:K07053	-	-	R00188,R11188	RC00078	ko00000,ko01000	-	-	-	PHP
HKD2_k127_4642278_38	1380408.AVGH01000005_gene2552	3.542e-36	142.0	COG2359@1|root,COG2359@2|Bacteria,1V6G8@1239|Firmicutes,4HIQV@91061|Bacilli,21VSA@150247|Anoxybacillus	91061|Bacilli	S	Stage V sporulation protein S (SpoVS)	spoVS	-	-	ko:K06416	-	-	-	-	ko00000	-	-	-	SpoVS
HKD2_k127_4642278_14	1118060.CAGZ01000024_gene562	2.379e-86	294.0	COG0323@1|root,COG0323@2|Bacteria,2H8CS@201174|Actinobacteria,4CUJV@84998|Coriobacteriia	84998|Coriobacteriia	L	histidine kinase DNA gyrase B	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HATPase_c_3
HKD2_k127_4656007_3	485913.Krac_11128	7.086e-09	66.0	COG0457@1|root,COG0457@2|Bacteria	485913.Krac_11128|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4656007_2	644966.Tmar_1534	1.109e-47	194.0	COG1874@1|root,COG3934@1|root,COG1874@2|Bacteria,COG3934@2|Bacteria,1UEWM@1239|Firmicutes,24AQC@186801|Clostridia	186801|Clostridia	G	Belongs to the glycosyl hydrolase 5 (cellulase A) family	-	-	3.2.1.23	ko:K01190	ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100	-	R01105,R01678,R03355,R04783,R06114	RC00049,RC00452	ko00000,ko00001,ko01000	-	-	-	Cellulase,Glyco_hydro_42M
HKD2_k127_4656007_1	574087.Acear_0860	7.379e-77	278.0	COG0517@1|root,COG2199@1|root,COG2200@1|root,COG0517@2|Bacteria,COG2199@2|Bacteria,COG2200@2|Bacteria,1TQ94@1239|Firmicutes,248BK@186801|Clostridia	186801|Clostridia	T	PFAM EAL domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS,EAL,GGDEF
HKD2_k127_4656007_0	479437.Elen_1684	1.495e-88	297.0	COG0709@1|root,COG0709@2|Bacteria,2GNP4@201174|Actinobacteria,4CUXI@84998|Coriobacteriia	84998|Coriobacteriia	H	Synthesizes selenophosphate from selenide and ATP	selD	-	2.7.9.3	ko:K01008	ko00450,ko01100,map00450,map01100	-	R03595	RC00002,RC02878	ko00000,ko00001,ko01000,ko03016	-	-	-	AIRS,AIRS_C
HKD2_k127_466183_3	521003.COLINT_02039	2.482e-118	394.0	COG0539@1|root,COG0539@2|Bacteria,2GJAK@201174|Actinobacteria,4CV59@84998|Coriobacteriia	84998|Coriobacteriia	J	Ribosomal protein S1	rpsA	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
HKD2_k127_466183_14	1449346.JQMO01000003_gene6254	1.351e-37	150.0	COG0237@1|root,COG0237@2|Bacteria,2GN96@201174|Actinobacteria,2M2KZ@2063|Kitasatospora	201174|Actinobacteria	H	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A	coaE	GO:0000166,GO:0001882,GO:0001884,GO:0002135,GO:0003674,GO:0003824,GO:0004140,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0018130,GO:0019103,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032549,GO:0032551,GO:0032552,GO:0032553,GO:0032554,GO:0032557,GO:0032558,GO:0032564,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.7.1.24	ko:K00859	ko00770,ko01100,map00770,map01100	M00120	R00130	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	CoaE,GrpB
HKD2_k127_466183_15	429009.Adeg_1021	1.319e-30	129.0	COG0741@1|root,COG0741@2|Bacteria,1V6K4@1239|Firmicutes,24JB5@186801|Clostridia,42GIF@68295|Thermoanaerobacterales	186801|Clostridia	M	PFAM Lytic transglycosylase catalytic	slt	-	-	ko:K08309	-	-	-	-	ko00000,ko01000,ko01011	-	GH23	-	SLT
HKD2_k127_466183_1	553204.CORAM0001_1970	5.564e-270	848.0	COG0556@1|root,COG0556@2|Bacteria,2GJ03@201174|Actinobacteria,22KA8@1653|Corynebacteriaceae	201174|Actinobacteria	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	GO:0002682,GO:0002684,GO:0005575,GO:0005623,GO:0005886,GO:0006950,GO:0008150,GO:0009605,GO:0009607,GO:0016020,GO:0035821,GO:0043207,GO:0044003,GO:0044403,GO:0044419,GO:0044464,GO:0048518,GO:0048583,GO:0048584,GO:0050776,GO:0050778,GO:0050789,GO:0050896,GO:0051409,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0052031,GO:0052173,GO:0052200,GO:0052255,GO:0052552,GO:0052553,GO:0052555,GO:0052556,GO:0052564,GO:0052572,GO:0065007,GO:0071944,GO:0075136	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
HKD2_k127_466183_4	1547437.LL06_23095	6.525e-117	383.0	COG0451@1|root,COG0451@2|Bacteria,1QUEV@1224|Proteobacteria,2TW46@28211|Alphaproteobacteria,43R32@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	M	NmrA-like family	-	-	4.2.1.45,4.2.1.46,5.1.3.2	ko:K01709,ko:K01710,ko:K01784	ko00052,ko00520,ko00521,ko00523,ko00525,ko01055,ko01100,ko01130,map00052,map00520,map00521,map00523,map00525,map01055,map01100,map01130	M00361,M00362,M00632,M00793	R00291,R02426,R02984,R06513	RC00289,RC00402	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
HKD2_k127_466183_2	1121456.ATVA01000012_gene2805	5.601e-145	466.0	COG0438@1|root,COG0535@1|root,COG0438@2|Bacteria,COG0535@2|Bacteria,1NB81@1224|Proteobacteria,42WA6@68525|delta/epsilon subdivisions,2WRYV@28221|Deltaproteobacteria,2MD0F@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1,SPASM
HKD2_k127_466183_12	908612.HMPREF9720_1339	3.239e-56	212.0	COG0438@1|root,COG0438@2|Bacteria,4NIP2@976|Bacteroidetes,2FQ2U@200643|Bacteroidia,22UK5@171550|Rikenellaceae	976|Bacteroidetes	M	Glycosyl transferase 4-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
HKD2_k127_466183_5	1464048.JNZS01000033_gene2824	1.215e-88	306.0	COG0438@1|root,COG0438@2|Bacteria,2IBM0@201174|Actinobacteria	201174|Actinobacteria	M	Glycosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
HKD2_k127_466183_6	134676.ACPL_7785	5.259e-80	287.0	COG2148@1|root,COG2148@2|Bacteria,2GK0M@201174|Actinobacteria,4D9NF@85008|Micromonosporales	201174|Actinobacteria	M	Sugar transferases involved in lipopolysaccharide synthesis	rfbP	-	-	-	-	-	-	-	-	-	-	-	Bac_transf,CoA_binding_3
HKD2_k127_466183_17	1227739.Hsw_1332	1.158e-09	68.0	2EUK8@1|root,33N26@2|Bacteria,4P8XW@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_466183_8	1194165.CAJF01000006_gene2408	2.025e-66	247.0	COG0661@1|root,COG0661@2|Bacteria,2GJQ6@201174|Actinobacteria,4FKT0@85023|Microbacteriaceae	201174|Actinobacteria	S	ABC1 family	-	-	-	ko:K03688	-	-	-	-	ko00000	-	-	-	ABC1,APH
HKD2_k127_466183_10	1122947.FR7_1916	1.728e-61	238.0	COG1136@1|root,COG1136@2|Bacteria,1TPBJ@1239|Firmicutes,4H22T@909932|Negativicutes	909932|Negativicutes	V	Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides	macB	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD2_k127_466183_18	1111131.HMPREF1255_0403	5.545e-06	57.0	COG1361@1|root,COG1361@2|Bacteria,2GP6I@201174|Actinobacteria	201174|Actinobacteria	M	Conserved repeat domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_466183_9	926569.ANT_07740	1.738e-62	231.0	COG0577@1|root,COG0577@2|Bacteria,2G6MK@200795|Chloroflexi	200795|Chloroflexi	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HKD2_k127_466183_13	471855.Shel_01960	1.083e-41	168.0	COG1316@1|root,COG1316@2|Bacteria,2GJM3@201174|Actinobacteria,4CUFS@84998|Coriobacteriia	84998|Coriobacteriia	K	TIGRFAM cell envelope-related function transcriptional attenuator	-	-	-	-	-	-	-	-	-	-	-	-	LytR_C,LytR_cpsA_psr
HKD2_k127_466183_7	1125863.JAFN01000001_gene1414	9.591e-78	293.0	COG1606@1|root,COG1606@2|Bacteria,1R7UZ@1224|Proteobacteria,42Q6V@68525|delta/epsilon subdivisions,2WKIM@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM asparagine synthase	-	-	-	ko:K06864	-	-	-	-	ko00000	-	-	-	Asn_synthase,NAD_synthase,QueC
HKD2_k127_466183_0	289376.THEYE_A0029	1.019e-292	916.0	COG0365@1|root,COG0365@2|Bacteria,3J0BJ@40117|Nitrospirae	40117|Nitrospirae	I	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	-	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
HKD2_k127_466183_16	205918.Psyr_4090	1.588e-26	119.0	COG2096@1|root,COG2096@2|Bacteria,1RDUF@1224|Proteobacteria,1S40D@1236|Gammaproteobacteria,1Z5GK@136849|Pseudomonas syringae group	1236|Gammaproteobacteria	S	ATP cob(I)alamin adenosyltransferase	pduO	-	2.5.1.17	ko:K00798	ko00860,ko01100,map00860,map01100	M00122	R01492,R05220,R07268	RC00533	ko00000,ko00001,ko00002,ko01000	-	-	-	Cob_adeno_trans,Haem_degrading
HKD2_k127_466183_11	1121456.ATVA01000018_gene315	9.204e-60	231.0	COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,42MN5@68525|delta/epsilon subdivisions,2WINN@28221|Deltaproteobacteria,2M9B2@213115|Desulfovibrionales	28221|Deltaproteobacteria	O	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen	glnD	-	2.7.7.59	ko:K00990	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	-	-	-	ACT,DUF294,GlnD_UR_UTase,GlnE,HD,NTP_transf_2
HKD2_k127_4698843_8	926560.KE387027_gene716	2.859e-13	83.0	COG2234@1|root,COG2234@2|Bacteria,1WIK7@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	PFAM Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
HKD2_k127_4698843_3	700015.Corgl_1792	3.421e-32	145.0	COG3266@1|root,COG3266@2|Bacteria,2I6AK@201174|Actinobacteria,4CVEE@84998|Coriobacteriia	84998|Coriobacteriia	S	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
HKD2_k127_4698843_4	709986.Deima_0121	9.845e-25	118.0	COG2199@1|root,COG3706@2|Bacteria,1WI95@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	T	TIGRFAM diguanylate cyclase (GGDEF) domain	-	-	-	-	-	-	-	-	-	-	-	-	CHASE3,GGDEF,HisKA_7TM,PAS_4
HKD2_k127_4698843_7	1305732.JAGG01000001_gene1178	1.834e-13	84.0	COG4478@1|root,COG4478@2|Bacteria,2IFW4@201174|Actinobacteria,4FS2J@85023|Microbacteriaceae	201174|Actinobacteria	S	Protein of unknown function (DUF1461)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1461
HKD2_k127_4698843_6	552811.Dehly_0525	5.249e-17	82.0	COG0550@1|root,COG0550@2|Bacteria	2|Bacteria	L	DNA topoisomerase type I activity	topB	-	5.99.1.2	ko:K03169	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	DEAD,HRDC,Helicase_C,RecQ_Zn_bind,Topoisom_bac,Toprim,Toprim_Crpt
HKD2_k127_4698843_1	742818.HMPREF9451_01686	4.471e-65	230.0	COG0569@1|root,COG0569@2|Bacteria,2GK4N@201174|Actinobacteria,4CUHI@84998|Coriobacteriia	84998|Coriobacteriia	C	TrkA-N domain	-	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_N
HKD2_k127_4698843_2	1384484.AEQU_0135	3.345e-51	190.0	COG0569@1|root,COG0569@2|Bacteria,2GKB9@201174|Actinobacteria,4CUFJ@84998|Coriobacteriia	84998|Coriobacteriia	C	TrkA-N domain	-	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
HKD2_k127_4698843_0	994573.T472_0207815	5.017e-164	532.0	COG0168@1|root,COG0168@2|Bacteria,1TPAF@1239|Firmicutes,248K4@186801|Clostridia,36E52@31979|Clostridiaceae	186801|Clostridia	P	potassium uptake protein TrkH	-	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
HKD2_k127_4698843_5	1280692.AUJL01000019_gene888	1.062e-21	111.0	2EDRU@1|root,337MD@2|Bacteria,1VIEE@1239|Firmicutes,24P45@186801|Clostridia,36KTK@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4698843_9	443906.CMM_1381	0.0002533	49.0	COG0739@1|root,COG0739@2|Bacteria,2IQ64@201174|Actinobacteria,4FTM3@85023|Microbacteriaceae	201174|Actinobacteria	M	Peptidase family M23	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
HKD2_k127_5118083_0	796606.BMMGA3_07090	6.849e-76	262.0	COG1089@1|root,COG1089@2|Bacteria,1TQ9T@1239|Firmicutes,4HB2M@91061|Bacilli,1ZE0N@1386|Bacillus	91061|Bacilli	M	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose	gmd	-	4.2.1.47	ko:K01711	ko00051,ko00520,ko01100,map00051,map00520,map01100	-	R00888	RC00402	ko00000,ko00001,ko01000	-	-	-	GDP_Man_Dehyd
HKD2_k127_5118083_1	926569.ANT_06540	6.126e-46	177.0	COG1215@1|root,COG1215@2|Bacteria,2G8MG@200795|Chloroflexi	200795|Chloroflexi	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HKD2_k127_5138491_7	1120973.AQXL01000123_gene3078	3.151e-59	208.0	COG0126@1|root,COG0126@2|Bacteria,1TP3H@1239|Firmicutes,4H9R3@91061|Bacilli,277XX@186823|Alicyclobacillaceae	91061|Bacilli	G	Belongs to the phosphoglycerate kinase family	pgk	GO:0001871,GO:0002020,GO:0003674,GO:0003824,GO:0004618,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009893,GO:0009986,GO:0009987,GO:0010468,GO:0010604,GO:0010628,GO:0010755,GO:0010756,GO:0010954,GO:0016052,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0017144,GO:0018130,GO:0019222,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0019899,GO:0030162,GO:0030193,GO:0030195,GO:0030246,GO:0030247,GO:0030312,GO:0031323,GO:0031325,GO:0032101,GO:0032102,GO:0032268,GO:0032270,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0043532,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0045862,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0048518,GO:0048519,GO:0048522,GO:0048583,GO:0048585,GO:0050789,GO:0050794,GO:0050818,GO:0050819,GO:0050878,GO:0051171,GO:0051173,GO:0051186,GO:0051188,GO:0051239,GO:0051241,GO:0051246,GO:0051247,GO:0051917,GO:0051919,GO:0055086,GO:0060255,GO:0061041,GO:0061045,GO:0065007,GO:0065008,GO:0070613,GO:0071704,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0080090,GO:0080134,GO:0090407,GO:1900046,GO:1900047,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1903034,GO:1903035,GO:1903317,GO:1903319,GO:2001065	2.7.2.3	ko:K00927	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01512	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iSB619.SA_RS04145	PGK
HKD2_k127_5138491_2	479437.Elen_1779	5.267e-158	504.0	COG0057@1|root,COG0057@2|Bacteria,2GJK4@201174|Actinobacteria,4CUJP@84998|Coriobacteriia	84998|Coriobacteriia	C	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family	gap	-	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Gp_dh_C,Gp_dh_N
HKD2_k127_5138491_4	1034345.CAEM01000019_gene1817	7.171e-112	370.0	COG1481@1|root,COG1481@2|Bacteria,2GJZU@201174|Actinobacteria,4CUY0@84998|Coriobacteriia	84998|Coriobacteriia	K	May be required for sporulation	whiA	-	-	ko:K09762	-	-	-	-	ko00000	-	-	-	HTH_WhiA,LAGLIDADG_WhiA,WhiA_N
HKD2_k127_5138491_6	264732.Moth_0259	1.178e-66	245.0	COG0391@1|root,COG0391@2|Bacteria,1TPNV@1239|Firmicutes,248G0@186801|Clostridia,42EVZ@68295|Thermoanaerobacterales	186801|Clostridia	S	Required for morphogenesis under gluconeogenic growth conditions	-	-	-	-	-	-	-	-	-	-	-	-	UPF0052
HKD2_k127_5138491_5	479437.Elen_1783	2.354e-89	316.0	COG1660@1|root,COG1660@2|Bacteria,2GMWB@201174|Actinobacteria,4CUJK@84998|Coriobacteriia	84998|Coriobacteriia	S	Displays ATPase and GTPase activities	-	-	-	ko:K06958	-	-	-	-	ko00000,ko03019	-	-	-	ATP_bind_2
HKD2_k127_5138491_9	266748.HY04_14655	1.218e-18	92.0	COG1950@1|root,COG1950@2|Bacteria,4NT2I@976|Bacteroidetes,1I40T@117743|Flavobacteriia,3ZSE6@59732|Chryseobacterium	976|Bacteroidetes	S	Mycobacterial 4 TMS phage holin, superfamily IV	yvlD	-	-	ko:K08972	-	-	-	-	ko00000	-	-	-	Phage_holin_4_2
HKD2_k127_5138491_1	1232436.CAPF01000005_gene1834	3.655e-212	678.0	COG0322@1|root,COG0322@2|Bacteria,2GIS4@201174|Actinobacteria,4CUKR@84998|Coriobacteriia	84998|Coriobacteriia	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	-	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N
HKD2_k127_5138491_0	1209989.TepiRe1_1777	0.0	1247.0	COG0178@1|root,COG0178@2|Bacteria,1TPIJ@1239|Firmicutes,2485F@186801|Clostridia,42EYE@68295|Thermoanaerobacterales	186801|Clostridia	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
HKD2_k127_5138491_3	1121428.DESHY_160166___1	2.475e-146	478.0	COG0004@1|root,COG0004@2|Bacteria,1TQYG@1239|Firmicutes,247W1@186801|Clostridia,2603A@186807|Peptococcaceae	186801|Clostridia	U	TIGRFAM Ammonium transporter	nrgA	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
HKD2_k127_5138491_8	1396418.BATQ01000175_gene2738	1.434e-42	161.0	COG0347@1|root,COG0347@2|Bacteria,46VXS@74201|Verrucomicrobia,2IUGB@203494|Verrucomicrobiae	203494|Verrucomicrobiae	E	Nitrogen regulatory protein P-II	-	-	-	-	-	-	-	-	-	-	-	-	P-II
HKD2_k127_5146081_7	502558.EGYY_04730	1.115e-76	260.0	COG0231@1|root,COG0231@2|Bacteria,2GJMS@201174|Actinobacteria,4CV48@84998|Coriobacteriia	84998|Coriobacteriia	J	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase	efp	-	-	ko:K02356	-	-	-	-	ko00000,ko03012	-	-	-	EFP,EFP_N,Elong-fact-P_C
HKD2_k127_5146081_0	479437.Elen_2542	3.384e-267	837.0	COG0511@1|root,COG5016@1|root,COG0511@2|Bacteria,COG5016@2|Bacteria,2IR3V@201174|Actinobacteria,4CUB4@84998|Coriobacteriia	84998|Coriobacteriia	CI	Acetyl-CoA carboxylase, biotin carboxyl carrier protein	-	-	4.1.1.3	ko:K01571	ko00620,ko01100,map00620,map01100	-	R00217	RC00040	ko00000,ko00001,ko01000,ko02000	3.B.1.1.1	-	-	Biotin_lipoyl,HMGL-like,PYC_OADA
HKD2_k127_5146081_3	696369.KI912183_gene1413	4.057e-188	599.0	COG0439@1|root,COG0439@2|Bacteria,1TP16@1239|Firmicutes,25E48@186801|Clostridia,26111@186807|Peptococcaceae	186801|Clostridia	I	TIGRFAM acetyl-CoA carboxylase, biotin carboxylase	accC	-	6.3.4.14,6.4.1.2	ko:K01961	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04385	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
HKD2_k127_5146081_15	649764.HMPREF0762_00745	5.351e-20	94.0	COG1302@1|root,COG1302@2|Bacteria,2HV5F@201174|Actinobacteria,4CWCD@84998|Coriobacteriia	84998|Coriobacteriia	S	Asp23 family, cell envelope-related function	-	-	-	-	-	-	-	-	-	-	-	-	Asp23
HKD2_k127_5146081_13	479437.Elen_2539	5.262e-35	141.0	COG0781@1|root,COG0781@2|Bacteria,2IM3D@201174|Actinobacteria,4CWB5@84998|Coriobacteriia	84998|Coriobacteriia	K	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons	nusB	-	-	ko:K03625	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	NusB
HKD2_k127_5146081_17	1125712.HMPREF1316_0408	0.0003381	48.0	2B1HU@1|root,31TYU@2|Bacteria,2HVBU@201174|Actinobacteria,4CWMQ@84998|Coriobacteriia	84998|Coriobacteriia	S	Exonuclease VII small subunit	-	-	-	-	-	-	-	-	-	-	-	-	Exonuc_VII_S
HKD2_k127_5146081_2	760568.Desku_1927	8.733e-227	721.0	COG1154@1|root,COG1154@2|Bacteria,1TP37@1239|Firmicutes,247P1@186801|Clostridia,2604R@186807|Peptococcaceae	186801|Clostridia	H	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)	dxs	-	2.2.1.7	ko:K01662	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	M00096	R05636	RC00032	ko00000,ko00001,ko00002,ko01000	-	-	-	DXP_synthase_N,Transket_pyr,Transketolase_C
HKD2_k127_5146081_8	936572.HMPREF1148_0997	2.466e-76	265.0	COG1189@1|root,COG1189@2|Bacteria,1TPE4@1239|Firmicutes,4H37C@909932|Negativicutes	909932|Negativicutes	J	Ribosomal RNA large subunit methyltransferase J	rrmJ	-	2.1.1.226,2.1.1.227	ko:K06442	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ,S4
HKD2_k127_5146081_12	1305732.JAGG01000001_gene1414	1.059e-42	169.0	COG0061@1|root,COG0061@2|Bacteria,2GKM2@201174|Actinobacteria,4FKIT@85023|Microbacteriaceae	201174|Actinobacteria	G	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	nadK	GO:0000166,GO:0003674,GO:0003824,GO:0003951,GO:0005488,GO:0005524,GO:0006082,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006741,GO:0006753,GO:0006793,GO:0006796,GO:0006797,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046496,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0051287,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	NAD_kinase
HKD2_k127_5146081_5	1504822.CCNO01000014_gene1090	1.238e-120	411.0	COG0497@1|root,COG0497@2|Bacteria,2NNUS@2323|unclassified Bacteria	2|Bacteria	L	May be involved in recombinational repair of damaged DNA	recN	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009295,GO:0009987,GO:0030312,GO:0033554,GO:0034641,GO:0042802,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:1901360	-	ko:K03631,ko:K13582	ko04112,map04112	-	-	-	ko00000,ko00001,ko03400	-	-	-	AAA_23,SMC_N
HKD2_k127_5146081_4	526225.Gobs_3007	1.371e-130	431.0	COG4825@1|root,COG4825@2|Bacteria,2GPAA@201174|Actinobacteria,4ERVF@85013|Frankiales	201174|Actinobacteria	S	Thiamine pyrophosphokinase C terminal	-	-	-	-	-	-	-	-	-	-	-	-	TPPK_C
HKD2_k127_5146081_16	1121422.AUMW01000001_gene2508	2.487e-09	68.0	28JWD@1|root,2Z9M5@2|Bacteria,1UZF1@1239|Firmicutes,24HZN@186801|Clostridia,261TF@186807|Peptococcaceae	186801|Clostridia	S	Copper transport outer membrane protein, MctB	-	-	-	-	-	-	-	-	-	-	-	-	MctB
HKD2_k127_5146081_9	868595.Desca_2088	9.97e-60	233.0	COG1215@1|root,COG1215@2|Bacteria,1TPBB@1239|Firmicutes,25E7R@186801|Clostridia,266RZ@186807|Peptococcaceae	186801|Clostridia	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HKD2_k127_5146081_6	502558.EGYY_10420	3.011e-106	372.0	COG0728@1|root,COG0728@2|Bacteria,2GKN0@201174|Actinobacteria,4CUPY@84998|Coriobacteriia	84998|Coriobacteriia	S	integral membrane protein MviN	-	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
HKD2_k127_5146081_10	696369.KI912183_gene384	2.716e-47	195.0	COG3119@1|root,COG3119@2|Bacteria,1TSMM@1239|Firmicutes,247YU@186801|Clostridia,260J3@186807|Peptococcaceae	186801|Clostridia	P	arylsulfatase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5146081_14	471856.Jden_1129	1.054e-28	131.0	COG0472@1|root,COG0472@2|Bacteria,2HS8K@201174|Actinobacteria	201174|Actinobacteria	M	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5146081_1	246194.CHY_0125	2.849e-251	784.0	COG0504@1|root,COG0504@2|Bacteria,1TP34@1239|Firmicutes,2482E@186801|Clostridia,42F21@68295|Thermoanaerobacterales	186801|Clostridia	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS01075	CTP_synth_N,GATase
HKD2_k127_5146081_11	635013.TherJR_1673	1.089e-44	176.0	COG2195@1|root,COG2195@2|Bacteria,1TP3A@1239|Firmicutes,248JJ@186801|Clostridia,26079@186807|Peptococcaceae	186801|Clostridia	E	TIGRFAM peptidase T-like protein	-	-	3.4.11.4	ko:K01258	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
HKD2_k127_5250485_10	869210.Marky_1392	2.837e-08	57.0	COG1959@1|root,COG1959@2|Bacteria,1WIBU@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	K	Transcriptional regulator, BadM Rrf2 family	-	-	-	-	-	-	-	-	-	-	-	-	Rrf2
HKD2_k127_5250485_0	246194.CHY_2199	3.919e-127	419.0	COG1104@1|root,COG1104@2|Bacteria,1TP21@1239|Firmicutes,24888@186801|Clostridia,42FGX@68295|Thermoanaerobacterales	186801|Clostridia	H	Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins	iscS	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
HKD2_k127_5250485_5	565033.GACE_1086	1.173e-51	188.0	COG0822@1|root,arCOG02077@2157|Archaea,2XX32@28890|Euryarchaeota,2467Y@183980|Archaeoglobi	183980|Archaeoglobi	C	NifU-like N terminal domain	-	-	-	ko:K04488	-	-	-	-	ko00000	-	-	-	NifU_N
HKD2_k127_5250485_1	479435.Kfla_4908	4.141e-88	304.0	COG0482@1|root,COG0482@2|Bacteria,2GIUQ@201174|Actinobacteria,4DPXG@85009|Propionibacteriales	201174|Actinobacteria	J	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34	mnmA	-	2.8.1.13	ko:K00566	ko04122,map04122	-	R08700	RC02313,RC02315	ko00000,ko00001,ko01000,ko03016	-	-	-	tRNA_Me_trans
HKD2_k127_5250485_2	1121468.AUBR01000006_gene354	2.035e-70	261.0	COG1387@1|root,COG1387@2|Bacteria,1UZ0M@1239|Firmicutes,24FSN@186801|Clostridia,42FB9@68295|Thermoanaerobacterales	186801|Clostridia	E	TIGRFAM histidinol phosphate phosphatase HisJ	hisJ	-	3.1.3.15	ko:K04486	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R03013	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PHP,PHP_C
HKD2_k127_5250485_4	1232410.KI421412_gene94	9.253e-55	211.0	COG0327@1|root,COG0327@2|Bacteria,1R34P@1224|Proteobacteria,42MAY@68525|delta/epsilon subdivisions,2X5HJ@28221|Deltaproteobacteria,43S5J@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	NIF3 (NGG1p interacting factor 3)	-	-	-	-	-	-	-	-	-	-	-	-	NIF3
HKD2_k127_5250485_9	1384484.AEQU_0831	2.232e-25	114.0	COG1579@1|root,COG1579@2|Bacteria,2HTFI@201174|Actinobacteria,4CVXI@84998|Coriobacteriia	84998|Coriobacteriia	S	zinc ribbon domain	-	-	-	ko:K07164	-	-	-	-	ko00000	-	-	-	zf-RING_7
HKD2_k127_5250485_7	644966.Tmar_2073	6.432e-35	141.0	COG0328@1|root,COG0328@2|Bacteria,1VAJW@1239|Firmicutes,24NJ8@186801|Clostridia	186801|Clostridia	L	PFAM ribonuclease H	rnhA	-	3.1.26.4	ko:K03469,ko:K06864	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RVT_3
HKD2_k127_5250485_8	552811.Dehly_1457	1.503e-33	132.0	COG0720@1|root,COG0720@2|Bacteria,2G7B6@200795|Chloroflexi,34DDV@301297|Dehalococcoidia	301297|Dehalococcoidia	H	6-pyruvoyl tetrahydropterin synthase	-	-	4.1.2.50,4.2.3.12	ko:K01737	ko00790,ko01100,map00790,map01100	M00842,M00843	R04286,R09959	RC01117,RC02846,RC02847	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	PTPS
HKD2_k127_5250485_6	861299.J421_4361	6.041e-40	157.0	COG1321@1|root,COG1918@1|root,COG1321@2|Bacteria,COG1918@2|Bacteria,1ZTHJ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	Helix-turn-helix diphteria tox regulatory element	-	-	-	ko:K03709	-	-	-	-	ko00000,ko03000	-	-	-	Fe_dep_repr_C,Fe_dep_repress,FeoA
HKD2_k127_5250485_3	871963.Desdi_1158	7.74e-58	225.0	COG3437@1|root,COG3437@2|Bacteria,1V7YT@1239|Firmicutes,25E5I@186801|Clostridia	186801|Clostridia	T	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,HD,HD_5
HKD2_k127_5513086_1	1273103.NM10_06023	4.215e-100	348.0	COG0744@1|root,COG0744@2|Bacteria,1TPM5@1239|Firmicutes,4H360@909932|Negativicutes	909932|Negativicutes	M	Penicillin-binding Protein	pbpD	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase
HKD2_k127_5513086_0	479437.Elen_0588	1.229e-162	522.0	COG0162@1|root,COG0162@2|Bacteria,2GJPR@201174|Actinobacteria,4CV92@84998|Coriobacteriia	84998|Coriobacteriia	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	-	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	S4,tRNA-synt_1b
HKD2_k127_5513086_2	887929.HMP0721_2517	1.644e-08	55.0	2DGK2@1|root,2ZWBC@2|Bacteria,1W4NY@1239|Firmicutes	1239|Firmicutes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5591071_8	469378.Ccur_11630	1.369e-83	280.0	COG0302@1|root,COG0302@2|Bacteria,2GP2P@201174|Actinobacteria,4CUPM@84998|Coriobacteriia	84998|Coriobacteriia	H	GTP cyclohydrolase	folE	-	3.5.4.16	ko:K01495	ko00790,ko01100,map00790,map01100	M00126,M00841,M00842,M00843	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	-	GTP_cyclohydroI
HKD2_k127_5591071_16	1262449.CP6013_4039	9.487e-46	186.0	COG1287@1|root,COG1287@2|Bacteria,1VJ25@1239|Firmicutes,25DSH@186801|Clostridia,36QI9@31979|Clostridiaceae	186801|Clostridia	S	oligosaccharyl transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5591071_4	471855.Shel_02040	2.559e-91	309.0	COG0294@1|root,COG0801@1|root,COG0294@2|Bacteria,COG0801@2|Bacteria,2GJDQ@201174|Actinobacteria,4CUFA@84998|Coriobacteriia	84998|Coriobacteriia	H	dihydropteroate synthase	folP	-	2.5.1.15	ko:K00796	ko00790,ko01100,map00790,map01100	M00126,M00841	R03066,R03067	RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	-	HPPK,Pterin_bind
HKD2_k127_5591071_18	1381123.AYOD01000002_gene557	3.133e-32	136.0	COG0801@1|root,COG0801@2|Bacteria,1MZH8@1224|Proteobacteria,2U8D6@28211|Alphaproteobacteria,43JXM@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	H	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	-	2.7.6.3,4.1.2.25	ko:K00950,ko:K13940	ko00790,ko01100,map00790,map01100	M00126,M00841	R03503,R03504	RC00002,RC00017,RC00721,RC00943	ko00000,ko00001,ko00002,ko01000	-	-	-	HPPK
HKD2_k127_5591071_6	358681.BBR47_25020	6.903e-91	310.0	COG0413@1|root,COG0413@2|Bacteria,1TPZA@1239|Firmicutes,4H9S8@91061|Bacilli,26RKF@186822|Paenibacillaceae	91061|Bacilli	H	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate	panB	-	2.1.2.11	ko:K00606	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R01226	RC00022,RC00200	ko00000,ko00001,ko00002,ko01000	-	-	iYO844.BSU22430	Pantoate_transf
HKD2_k127_5591071_9	1382304.JNIL01000001_gene811	1.311e-81	284.0	COG0414@1|root,COG0414@2|Bacteria,1TP7A@1239|Firmicutes,4HAIQ@91061|Bacilli,2784W@186823|Alicyclobacillaceae	91061|Bacilli	H	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate	panC	GO:0003674,GO:0003824,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006573,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605	6.3.2.1	ko:K01918	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R02473	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_ligase
HKD2_k127_5591071_2	926567.TheveDRAFT_0103	2.413e-101	339.0	COG0379@1|root,COG0379@2|Bacteria	2|Bacteria	H	quinolinate synthetase A activity	nadA	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008987,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016053,GO:0017144,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0019805,GO:0030312,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0040007,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046496,GO:0046874,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0055086,GO:0071704,GO:0071944,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	2.5.1.72	ko:K03517	ko00760,ko01100,map00760,map01100	M00115	R04292	RC01119	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS12020	NadA
HKD2_k127_5591071_1	696369.KI912183_gene2384	8.086e-141	469.0	COG0029@1|root,COG0029@2|Bacteria,1UHSP@1239|Firmicutes,25E6F@186801|Clostridia,260KQ@186807|Peptococcaceae	186801|Clostridia	H	Catalyzes the oxidation of L-aspartate to iminoaspartate	nadB	-	1.4.3.16	ko:K00278	ko00250,ko00760,ko01100,map00250,map00760,map01100	M00115	R00357,R00481	RC00006,RC02566	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
HKD2_k127_5591071_14	298654.FraEuI1c_0170	1.177e-51	195.0	COG0157@1|root,COG0157@2|Bacteria,2I2IP@201174|Actinobacteria	201174|Actinobacteria	H	Belongs to the NadC ModD family	nadC	-	2.4.2.19	ko:K00767	ko00760,ko01100,map00760,map01100	M00115	R03348	RC02877	ko00000,ko00001,ko00002,ko01000	-	-	-	QRPTase_C,QRPTase_N
HKD2_k127_5591071_19	1267534.KB906755_gene4134	5.7e-24	114.0	COG0586@1|root,COG0586@2|Bacteria,3Y7VY@57723|Acidobacteria,2JMWT@204432|Acidobacteriia	204432|Acidobacteriia	S	SNARE associated Golgi protein	-	-	-	ko:K03975	-	-	-	-	ko00000	-	-	-	SNARE_assoc
HKD2_k127_5591071_15	404589.Anae109_1479	5.685e-51	197.0	COG0340@1|root,COG1654@1|root,COG0340@2|Bacteria,COG1654@2|Bacteria,1MWCC@1224|Proteobacteria,42P6I@68525|delta/epsilon subdivisions,2WMAF@28221|Deltaproteobacteria,2YVIU@29|Myxococcales	28221|Deltaproteobacteria	H	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor	birA	-	6.3.4.15	ko:K03524	ko00780,ko01100,map00780,map01100	-	R01074,R05145	RC00043,RC00070,RC00096,RC02896	ko00000,ko00001,ko01000,ko03000	-	-	-	BPL_C,BPL_LplA_LipB,HTH_11
HKD2_k127_5591071_20	502558.EGYY_03000	1.144e-19	102.0	COG1268@1|root,COG1268@2|Bacteria,2HV4C@201174|Actinobacteria,4CWA5@84998|Coriobacteriia	84998|Coriobacteriia	S	BioY family	-	-	-	ko:K03523	ko02010,map02010	M00581,M00582	-	-	ko00000,ko00001,ko00002,ko02000	2.A.88.1,2.A.88.2	-	-	BioY
HKD2_k127_5591071_12	649764.HMPREF0762_00935	6.498e-59	222.0	COG0642@1|root,COG2205@2|Bacteria,2GIV9@201174|Actinobacteria,4CUUH@84998|Coriobacteriia	84998|Coriobacteriia	T	histidine kinase DNA gyrase B	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
HKD2_k127_5591071_3	1034345.CAEM01000006_gene1348	8.422e-93	314.0	COG0745@1|root,COG0745@2|Bacteria,2GK5S@201174|Actinobacteria,4CYGP@84998|Coriobacteriia	84998|Coriobacteriia	K	Transcriptional regulatory protein, C terminal	-	-	-	ko:K07776	ko02020,map02020	M00443	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
HKD2_k127_5591071_10	717605.Theco_3678	4.585e-77	266.0	COG1521@1|root,COG1521@2|Bacteria,1TR0X@1239|Firmicutes,4H9QA@91061|Bacilli,26RR9@186822|Paenibacillaceae	91061|Bacilli	H	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis	coaX	-	2.7.1.33	ko:K03525	ko00770,ko01100,map00770,map01100	M00120	R02971,R03018,R04391	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Pan_kinase
HKD2_k127_5591071_17	264732.Moth_0148	1.234e-37	149.0	2AVM5@1|root,31MDW@2|Bacteria,1V7D6@1239|Firmicutes,24JAJ@186801|Clostridia,42G0V@68295|Thermoanaerobacterales	186801|Clostridia	S	PFAM helix-turn-helix domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
HKD2_k127_5591071_7	935948.KE386495_gene1580	1.917e-86	303.0	COG5322@1|root,COG5322@2|Bacteria,1TQ2E@1239|Firmicutes,24A1Y@186801|Clostridia,42EUN@68295|Thermoanaerobacterales	186801|Clostridia	S	oxidoreductase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5591071_21	521003.COLINT_03354	2.517e-09	66.0	COG2332@1|root,COG2332@2|Bacteria,2HUFT@201174|Actinobacteria,4CUH1@84998|Coriobacteriia	84998|Coriobacteriia	O	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH	-	-	-	ko:K02197	-	-	-	-	ko00000	-	-	-	CcmE
HKD2_k127_5591071_0	742742.HMPREF9452_01050	2.386e-143	480.0	COG1138@1|root,COG1138@2|Bacteria,2HZM9@201174|Actinobacteria,4CV75@84998|Coriobacteriia	84998|Coriobacteriia	O	biogenesis protein CcmF	-	-	-	ko:K02198	-	-	-	-	ko00000,ko02000	9.B.14.1	-	-	CcmF_C,Cytochrom_C_asm
HKD2_k127_5591071_5	742818.HMPREF9451_01209	4.106e-91	306.0	COG1131@1|root,COG1131@2|Bacteria,2H5DY@201174|Actinobacteria,4CV85@84998|Coriobacteriia	84998|Coriobacteriia	V	PFAM ABC transporter	-	-	3.6.3.41,3.6.3.7	ko:K01990,ko:K02193,ko:K09697	ko02010,ko02020,map02010,map02020	M00253,M00254,M00259	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.107,3.A.1.115	-	-	ABC_tran,Rad17
HKD2_k127_5591071_11	649764.HMPREF0762_00777	1.346e-62	223.0	COG2386@1|root,COG2386@2|Bacteria,2GUCP@201174|Actinobacteria,4CV8U@84998|Coriobacteriia	84998|Coriobacteriia	O	heme exporter protein CcmB	-	-	-	ko:K02194	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.107	-	-	CcmB
HKD2_k127_5591071_13	479437.Elen_2580	7.181e-59	212.0	COG0755@1|root,COG0755@2|Bacteria,2IIHK@201174|Actinobacteria,4CU7P@84998|Coriobacteriia	84998|Coriobacteriia	O	Cytochrome c assembly protein	-	-	-	ko:K02195	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.107	-	-	Cytochrom_C_asm
HKD2_k127_5598455_14	471855.Shel_14190	1.508e-05	53.0	COG3597@1|root,COG3597@2|Bacteria,2GZU9@201174|Actinobacteria,4CVH2@84998|Coriobacteriia	84998|Coriobacteriia	S	protein domain associated with	-	-	-	-	-	-	-	-	-	-	-	-	DUF697
HKD2_k127_5598455_2	1235794.C811_00379	1.858e-94	321.0	COG0772@1|root,COG0772@2|Bacteria,2GK2G@201174|Actinobacteria,4CUE2@84998|Coriobacteriia	84998|Coriobacteriia	D	Belongs to the SEDS family	-	-	-	ko:K05837	-	-	-	-	ko00000,ko03036	-	-	-	FTSW_RODA_SPOVE
HKD2_k127_5598455_1	866774.HMPREF9248_1086	8.779e-146	482.0	COG0768@1|root,COG0768@2|Bacteria,2GJ61@201174|Actinobacteria,4CUTW@84998|Coriobacteriia	84998|Coriobacteriia	M	Penicillin-binding protein 2	mrdA	-	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	-	PBP_dimer,Transpeptidase
HKD2_k127_5598455_11	485916.Dtox_3337	2.384e-13	78.0	COG2891@1|root,COG2891@2|Bacteria,1V1EJ@1239|Firmicutes,24RP5@186801|Clostridia,262R9@186807|Peptococcaceae	186801|Clostridia	M	shape-determining protein MreD	mreD	-	-	ko:K03571	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreD
HKD2_k127_5598455_6	742722.HMPREF9463_01720	5.816e-56	206.0	COG1792@1|root,COG1792@2|Bacteria,2GJN0@201174|Actinobacteria,4CUZG@84998|Coriobacteriia	84998|Coriobacteriia	M	Involved in formation and maintenance of cell shape	mreC	-	-	ko:K03570	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreC
HKD2_k127_5598455_0	742722.HMPREF9463_01721	2.326e-149	480.0	COG1077@1|root,COG1077@2|Bacteria,2GMD1@201174|Actinobacteria,4CU7F@84998|Coriobacteriia	84998|Coriobacteriia	D	Cell shape determining protein, MreB Mrl family	-	-	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
HKD2_k127_5598455_9	1121468.AUBR01000001_gene497	6.989e-51	188.0	COG2003@1|root,COG2003@2|Bacteria,1TQ3K@1239|Firmicutes,2498Z@186801|Clostridia,42EWM@68295|Thermoanaerobacterales	186801|Clostridia	L	Belongs to the UPF0758 family	radC	-	-	ko:K03630	-	-	-	-	ko00000	-	-	-	RadC
HKD2_k127_5598455_12	484770.UFO1_2948	1.068e-10	71.0	COG4769@1|root,COG4769@2|Bacteria,1V1M0@1239|Firmicutes,4H51B@909932|Negativicutes	909932|Negativicutes	S	Heptaprenyl diphosphate synthase component I	-	-	2.5.1.30	ko:K00805	ko00900,ko01110,map00900,map01110	-	R09247	RC00279	ko00000,ko00001,ko01000,ko01006	-	-	-	Hpre_diP_synt_I
HKD2_k127_5598455_13	1232410.KI421412_gene64	4.942e-08	59.0	COG5341@1|root,COG5341@2|Bacteria,1PWPS@1224|Proteobacteria,42WCM@68525|delta/epsilon subdivisions,2WRY0@28221|Deltaproteobacteria,43SRG@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	NusG domain II	-	-	-	-	-	-	-	-	-	-	-	-	NusG_II
HKD2_k127_5598455_4	555079.Toce_0703	1.594e-66	239.0	COG1036@1|root,COG1142@1|root,COG2878@1|root,COG1036@2|Bacteria,COG1142@2|Bacteria,COG2878@2|Bacteria,1TQGD@1239|Firmicutes,24904@186801|Clostridia,42G67@68295|Thermoanaerobacterales	186801|Clostridia	C	TIGRFAM electron transport complex, RnfABCDGE type, B subunit	rnfB	-	-	ko:K03616	-	-	-	-	ko00000	-	-	-	FeS,Fer4,Fer4_13,Fer4_4,Fer4_9
HKD2_k127_5598455_7	717231.Flexsi_1445	3.073e-51	189.0	COG4657@1|root,COG4657@2|Bacteria,2GETG@200930|Deferribacteres	200930|Deferribacteres	C	Part of a membrane complex involved in electron transport	-	-	-	ko:K03617	-	-	-	-	ko00000	-	-	-	Rnf-Nqr
HKD2_k127_5598455_8	309799.DICTH_0966	4.169e-51	188.0	COG4660@1|root,COG4660@2|Bacteria	2|Bacteria	C	electron transport chain	rnfE	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0044464,GO:0055114,GO:0071944	2.3.1.243,4.2.99.18	ko:K02560,ko:K03613,ko:K10773	ko00540,ko01100,ko03410,map00540,map01100,map03410	M00060	R05075	RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01005,ko03400	-	-	iHN637.CLJU_RS05585	Rnf-Nqr
HKD2_k127_5598455_10	203119.Cthe_2432	1.452e-17	90.0	COG4659@1|root,COG4659@2|Bacteria,1V7R1@1239|Firmicutes,24JVM@186801|Clostridia	186801|Clostridia	C	Part of a membrane complex involved in electron transport	rnfG	-	-	ko:K03612	-	-	-	-	ko00000	-	-	-	FMN_bind
HKD2_k127_5598455_3	555079.Toce_0699	2.549e-68	252.0	COG4658@1|root,COG4658@2|Bacteria,1TQAY@1239|Firmicutes,247TM@186801|Clostridia,42FR3@68295|Thermoanaerobacterales	186801|Clostridia	C	Part of a membrane complex involved in electron transport	rnfD	-	-	ko:K03614	-	-	-	-	ko00000	-	-	-	NQR2_RnfD_RnfE
HKD2_k127_5598455_5	1307761.L21SP2_0448	2.379e-64	226.0	COG4656@1|root,COG4656@2|Bacteria,2J5TG@203691|Spirochaetes	203691|Spirochaetes	C	Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily	rnfC	-	-	ko:K03615	-	-	-	-	ko00000	-	-	-	Complex1_51K,Fer4_10,Fer4_8,RnfC_N,SLBB
HKD2_k127_5627941_0	401526.TcarDRAFT_2174	1.644e-90	305.0	COG0541@1|root,COG0541@2|Bacteria,1TP06@1239|Firmicutes,4H29G@909932|Negativicutes	909932|Negativicutes	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY	ffh	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
HKD2_k127_5627941_8	1125712.HMPREF1316_0247	8.212e-26	113.0	COG0228@1|root,COG0228@2|Bacteria,2IKU0@201174|Actinobacteria,4CWB2@84998|Coriobacteriia	84998|Coriobacteriia	J	Belongs to the bacterial ribosomal protein bS16 family	rpsP	-	-	ko:K02959	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S16
HKD2_k127_5627941_10	867903.ThesuDRAFT_00296	1.7e-17	84.0	COG1837@1|root,COG1837@2|Bacteria,1VEG7@1239|Firmicutes,24QKN@186801|Clostridia,3WDJD@538999|Clostridiales incertae sedis	186801|Clostridia	S	Belongs to the UPF0109 family	ylqC	-	-	ko:K06960	-	-	-	-	ko00000	-	-	-	KH_4
HKD2_k127_5627941_9	445975.COLSTE_01536	8.105e-20	95.0	COG0806@1|root,COG0806@2|Bacteria,2HV43@201174|Actinobacteria,4CW9R@84998|Coriobacteriia	84998|Coriobacteriia	J	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes	rimM	-	-	ko:K02860	-	-	-	-	ko00000,ko03009	-	-	-	RimM
HKD2_k127_5627941_1	661087.HMPREF1008_01387	4.481e-82	287.0	COG0336@1|root,COG0336@2|Bacteria,2GJ1G@201174|Actinobacteria,4CV1X@84998|Coriobacteriia	84998|Coriobacteriia	J	Belongs to the RNA methyltransferase TrmD family	trmD	-	2.1.1.228	ko:K00554	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	tRNA_m1G_MT
HKD2_k127_5627941_3	1384484.AEQU_1260	4.565e-48	178.0	COG0681@1|root,COG0681@2|Bacteria,2GIYN@201174|Actinobacteria,4CVY4@84998|Coriobacteriia	84998|Coriobacteriia	U	Belongs to the peptidase S26 family	lepB	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S26
HKD2_k127_5627941_4	1034345.CAEM01000019_gene1661	2.692e-46	169.0	COG0335@1|root,COG0335@2|Bacteria,2IHRT@201174|Actinobacteria,4CVXA@84998|Coriobacteriia	84998|Coriobacteriia	J	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site	rplS	-	-	ko:K02884	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L19
HKD2_k127_5627941_6	292459.STH2445	4.849e-41	160.0	COG0681@1|root,COG0681@2|Bacteria,1V7H9@1239|Firmicutes,24MVR@186801|Clostridia	186801|Clostridia	U	Belongs to the peptidase S26 family	lepB	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24
HKD2_k127_5627941_5	1123302.KB904173_gene295	2.595e-42	172.0	COG0164@1|root,COG0164@2|Bacteria,1V1D6@1239|Firmicutes,4HB7M@91061|Bacilli	91061|Bacilli	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhB	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576	3.1.26.4	ko:K03470	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_HII
HKD2_k127_5627941_7	211114.JOEF01000013_gene5002	1.717e-28	118.0	COG0792@1|root,COG0792@2|Bacteria,2IQ3X@201174|Actinobacteria,4E5Y2@85010|Pseudonocardiales	201174|Actinobacteria	L	Belongs to the UPF0102 family	yraN	-	-	ko:K07460	-	-	-	-	ko00000	-	-	-	UPF0102
HKD2_k127_5627941_2	1125973.JNLC01000011_gene389	8.218e-82	286.0	COG0606@1|root,COG0606@2|Bacteria,1MU4R@1224|Proteobacteria,2TQU6@28211|Alphaproteobacteria,3JVC0@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	O	Magnesium chelatase, subunit ChlI C-terminal	comM	-	-	ko:K07391	-	-	-	-	ko00000	-	-	-	ChlI,Mg_chelatase,Mg_chelatase_C
HKD2_k127_5678909_0	1095772.CAHH01000042_gene1237	7.204e-157	517.0	COG2804@1|root,COG2804@2|Bacteria,2I8C2@201174|Actinobacteria	201174|Actinobacteria	NU	type II secretion system protein E	pilB	-	-	ko:K02652	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE,T2SSE_N
HKD2_k127_5678909_1	760568.Desku_1902	2.561e-143	465.0	COG1015@1|root,COG1015@2|Bacteria,1TP70@1239|Firmicutes,247WB@186801|Clostridia,260HR@186807|Peptococcaceae	186801|Clostridia	G	Phosphotransfer between the C1 and C5 carbon atoms of pentose	deoB	-	5.4.2.7	ko:K01839	ko00030,ko00230,map00030,map00230	-	R01057,R02749	RC00408	ko00000,ko00001,ko01000	-	-	-	Metalloenzyme
HKD2_k127_5678909_2	1345697.M493_11905	1.272e-142	470.0	COG0213@1|root,COG0213@2|Bacteria,1TPCH@1239|Firmicutes,4H9NP@91061|Bacilli,1WEBN@129337|Geobacillus	91061|Bacilli	F	Catalyzes the reversible phosphorolysis of thymidine, deoxyuridine and their analogues to their respective bases and 2-deoxyribose 1-phosphate	deoA	GO:0003674,GO:0003824,GO:0004645,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0009032,GO:0016740,GO:0016757,GO:0016758,GO:0016763,GO:0044424,GO:0044444,GO:0044464	2.4.2.2	ko:K00756	ko00240,ko01100,map00240,map01100	-	R01570,R01876,R02296,R02484	RC00063	ko00000,ko00001,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3,PYNP_C
HKD2_k127_5678909_3	880072.Desac_0373	6.006e-38	149.0	COG0517@1|root,COG0617@1|root,COG0618@1|root,COG0517@2|Bacteria,COG0617@2|Bacteria,COG0618@2|Bacteria,1MU2X@1224|Proteobacteria,42MJJ@68525|delta/epsilon subdivisions,2WJBN@28221|Deltaproteobacteria,2MQAY@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	tRNA nucleotidyltransferase poly(A) polymerase	ccaA	-	2.7.7.72	ko:K00974	ko03013,map03013	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko00001,ko01000,ko03016	-	-	-	CBS,DHH,DHHA1,PolyA_pol,PolyA_pol_RNAbd
HKD2_k127_5695468_2	913865.DOT_5366	9.131e-27	119.0	COG0835@1|root,COG0835@2|Bacteria,1V4HH@1239|Firmicutes,24JV4@186801|Clostridia,261WX@186807|Peptococcaceae	186801|Clostridia	NT	Chemotaxis signal transduction protein	-	-	-	ko:K03408	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheW
HKD2_k127_5695468_0	1120973.AQXL01000088_gene3240	3.344e-60	225.0	COG0840@1|root,COG0840@2|Bacteria,1TP5A@1239|Firmicutes,4H9RZ@91061|Bacilli,279IT@186823|Alicyclobacillaceae	91061|Bacilli	NT	Cache domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,MCPsignal,dCache_1
HKD2_k127_5695468_1	351160.LRC584	2.709e-55	205.0	COG1352@1|root,arCOG04402@2157|Archaea,2XU3Q@28890|Euryarchaeota,2N9NH@224756|Methanomicrobia	224756|Methanomicrobia	N	PFAM MCP methyltransferase CheR-type	cheR	-	2.1.1.80	ko:K00575	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko01000,ko02035	-	-	-	CheR,CheR_N
HKD2_k127_5695468_3	929712.KI912613_gene712	1.065e-24	121.0	COG1376@1|root,COG1376@2|Bacteria,2HSK1@201174|Actinobacteria,4CS2R@84995|Rubrobacteria	84995|Rubrobacteria	S	Putative peptidoglycan binding domain	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_4,YkuD
HKD2_k127_5695468_4	443144.GM21_3108	1.204e-15	92.0	COG3303@1|root,COG3303@2|Bacteria,1PEVM@1224|Proteobacteria	1224|Proteobacteria	C	Doubled CXXCH motif (Paired_CXXCH_1)	-	-	-	-	-	-	-	-	-	-	-	-	Paired_CXXCH_1
HKD2_k127_5695468_7	929712.KI912613_gene2332	1.144e-06	63.0	COG2931@1|root,COG3391@1|root,COG2931@2|Bacteria,COG3391@2|Bacteria,2I6II@201174|Actinobacteria,4CSU7@84995|Rubrobacteria	84995|Rubrobacteria	G	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella	-	-	-	-	-	-	-	-	-	-	-	-	Collagen,VCBS
HKD2_k127_5695468_5	635013.TherJR_1130	1.263e-07	66.0	COG4733@1|root,COG4733@2|Bacteria,1TQ2T@1239|Firmicutes,24EP0@186801|Clostridia,265Y1@186807|Peptococcaceae	186801|Clostridia	C	Fibronectin type III domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CARDB,PKD,Paired_CXXCH_1,SLH,fn3
HKD2_k127_5695468_6	1123319.AUBE01000031_gene5077	5.246e-07	63.0	COG3386@1|root,COG3386@2|Bacteria	2|Bacteria	G	gluconolactonase activity	-	-	-	ko:K14274	ko00040,map00040	-	R02427	RC00713	ko00000,ko00001,ko01000	-	-	-	BPD_transp_2,CHU_C,DUF5122,NHL,SGL,Str_synth
HKD2_k127_5757069_10	243365.CV_3888	1.03e-76	270.0	COG2227@1|root,COG2227@2|Bacteria,1PMA5@1224|Proteobacteria,2W9ZH@28216|Betaproteobacteria,2KSUV@206351|Neisseriales	206351|Neisseriales	H	Methionine biosynthesis protein MetW	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23
HKD2_k127_5757069_17	401053.AciPR4_1481	9.691e-12	76.0	COG2246@1|root,COG2246@2|Bacteria,3Y5R8@57723|Acidobacteria,2JK12@204432|Acidobacteriia	204432|Acidobacteriia	S	GtrA-like protein	-	-	-	-	-	-	-	-	-	-	-	-	GtrA
HKD2_k127_5757069_16	234267.Acid_2688	6.825e-15	89.0	2FA7C@1|root,342G0@2|Bacteria,3Y93S@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5757069_3	1121033.AUCF01000009_gene1148	5.573e-114	386.0	COG0836@1|root,COG0836@2|Bacteria,1MV39@1224|Proteobacteria,2TT0R@28211|Alphaproteobacteria,2JRI0@204441|Rhodospirillales	204441|Rhodospirillales	GM	Belongs to the mannose-6-phosphate isomerase type 2 family	cpsB	-	2.7.7.13,5.3.1.8	ko:K16011	ko00051,ko00520,ko01100,ko01110,ko01130,ko02025,map00051,map00520,map01100,map01110,map01130,map02025	M00114,M00362	R00885,R01819	RC00002,RC00376	ko00000,ko00001,ko00002,ko01000	-	-	-	MannoseP_isomer,NTP_transferase
HKD2_k127_5757069_2	926569.ANT_06290	5.668e-141	461.0	COG0451@1|root,COG0451@2|Bacteria,2G7M6@200795|Chloroflexi	200795|Chloroflexi	GM	Catalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction	fcl	-	1.1.1.271	ko:K02377	ko00051,ko00520,ko01100,map00051,map00520,map01100	-	R05692	RC01014	ko00000,ko00001,ko01000	-	-	-	Epimerase
HKD2_k127_5757069_11	671143.DAMO_0303	2.101e-66	239.0	COG1216@1|root,COG1216@2|Bacteria,2NNYJ@2323|unclassified Bacteria	2|Bacteria	S	Glycosyl transferase family 2	-	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2
HKD2_k127_5757069_7	1121346.KB899822_gene2895	8.244e-102	341.0	COG2089@1|root,COG2089@2|Bacteria,1TS09@1239|Firmicutes,4HA1Y@91061|Bacilli,26UX8@186822|Paenibacillaceae	91061|Bacilli	M	NeuB family	-	-	2.5.1.56	ko:K01654	ko00520,ko01100,map00520,map01100	-	R01804,R04435	RC00159	ko00000,ko00001,ko01000	-	-	-	NeuB,SAF
HKD2_k127_5757069_5	1121346.KB899822_gene2892	2.23e-102	350.0	COG1052@1|root,COG1052@2|Bacteria,1TPCX@1239|Firmicutes,4HUAD@91061|Bacilli	91061|Bacilli	CH	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family	serA	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C,ACT
HKD2_k127_5757069_6	1121346.KB899822_gene2891	7.084e-102	353.0	COG0028@1|root,COG0028@2|Bacteria,1TQE8@1239|Firmicutes,4HAV1@91061|Bacilli	91061|Bacilli	EH	Belongs to the TPP enzyme family	alsS	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
HKD2_k127_5757069_4	1121346.KB899822_gene2890	1.867e-104	361.0	COG0673@1|root,COG0673@2|Bacteria,1UP62@1239|Firmicutes,4HVSN@91061|Bacilli,27109@186822|Paenibacillaceae	91061|Bacilli	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
HKD2_k127_5757069_9	1121346.KB899822_gene2889	5.286e-82	282.0	COG1083@1|root,COG1083@2|Bacteria,1UFAT@1239|Firmicutes,4HG7P@91061|Bacilli,26T1N@186822|Paenibacillaceae	91061|Bacilli	M	Cytidylyltransferase	neuA	-	2.7.7.43,2.7.7.82	ko:K00983,ko:K18431	ko00520,ko01100,map00520,map01100	-	R01117,R04215,R10182	RC00152	ko00000,ko00001,ko01000	-	-	-	CTP_transf_3,Lipase_GDSL_2
HKD2_k127_5757069_1	1121346.KB899822_gene2894	7.634e-172	547.0	COG0381@1|root,COG0381@2|Bacteria,1TQKQ@1239|Firmicutes,4HBW7@91061|Bacilli,26VN1@186822|Paenibacillaceae	91061|Bacilli	M	UDP-N-acetylglucosamine 2-epimerase	-	-	3.2.1.183,3.2.1.184	ko:K08068,ko:K18429	ko00520,map00520	-	R10187	RC00005,RC00288	ko00000,ko00001,ko01000	-	-	-	Epimerase_2
HKD2_k127_5757069_13	1167006.UWK_02424	1.617e-57	218.0	COG2227@1|root,COG2227@2|Bacteria,1RC6B@1224|Proteobacteria,42WK2@68525|delta/epsilon subdivisions	1224|Proteobacteria	H	PFAM Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23
HKD2_k127_5757069_0	1089551.KE386572_gene1277	8.603e-182	585.0	COG0763@1|root,COG0763@2|Bacteria,1QYVV@1224|Proteobacteria,2TY03@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5757069_14	1267534.KB906757_gene901	1.953e-30	139.0	COG2244@1|root,COG2244@2|Bacteria,3Y8IW@57723|Acidobacteria	57723|Acidobacteria	S	polysaccharide biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5757069_15	319225.Plut_1849	3.335e-25	113.0	COG0110@1|root,COG0110@2|Bacteria	2|Bacteria	S	O-acyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep,Hexapep_2
HKD2_k127_5757069_8	1089551.KE386572_gene1273	1.418e-83	286.0	COG4122@1|root,COG4122@2|Bacteria,1REAM@1224|Proteobacteria,2UPT1@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_24
HKD2_k127_5929732_0	316058.RPB_0810	2.69e-151	497.0	COG0366@1|root,COG0366@2|Bacteria,1MVKX@1224|Proteobacteria,2TRS3@28211|Alphaproteobacteria,3JS80@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Alpha-amylase domain	MA20_23410	-	3.2.1.20	ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R06087,R06088	RC00028,RC00049,RC00077	ko00000,ko00001,ko01000	-	GH31	-	Alpha-amylase,DUF3459
HKD2_k127_5929732_6	246194.CHY_0604	3.751e-35	147.0	COG3005@1|root,COG3005@2|Bacteria,1VBE7@1239|Firmicutes,2527F@186801|Clostridia	186801|Clostridia	C	NapC/NirT cytochrome c family, N-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5929732_8	635013.TherJR_1847	1.569e-24	116.0	COG3005@1|root,COG3005@2|Bacteria,1VTRU@1239|Firmicutes,2500S@186801|Clostridia,264IC@186807|Peptococcaceae	186801|Clostridia	C	denitrification pathway	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5929732_7	635013.TherJR_1118	6.55e-31	132.0	COG3005@1|root,COG3005@2|Bacteria,1VBE7@1239|Firmicutes,24YVE@186801|Clostridia,2672I@186807|Peptococcaceae	186801|Clostridia	C	NapC/NirT cytochrome c family, N-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_NNT
HKD2_k127_5929732_10	635013.TherJR_1847	1.135e-14	85.0	COG3005@1|root,COG3005@2|Bacteria,1VTRU@1239|Firmicutes,2500S@186801|Clostridia,264IC@186807|Peptococcaceae	186801|Clostridia	C	denitrification pathway	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5929732_4	768706.Desor_3109	1.649e-46	184.0	COG5557@1|root,COG5557@2|Bacteria,1V4C0@1239|Firmicutes,24NSE@186801|Clostridia,264M3@186807|Peptococcaceae	186801|Clostridia	C	Polysulphide reductase, NrfD	-	-	-	ko:K00185	-	-	-	-	ko00000	5.A.3	-	-	NrfD
HKD2_k127_5929732_2	983917.RGE_33760	1.02e-68	254.0	COG0437@1|root,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,2VKVM@28216|Betaproteobacteria,1KNAF@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	4Fe-4S dicluster domain	-	-	-	ko:K00184	-	-	-	-	ko00000	5.A.3	-	-	Fer4_11,Fer4_3,Fer4_4,Fer4_7
HKD2_k127_5929732_11	404589.Anae109_2408	2.764e-12	76.0	28JYU@1|root,2Z9NZ@2|Bacteria,1N5J2@1224|Proteobacteria,42UJJ@68525|delta/epsilon subdivisions,2X7XY@28221|Deltaproteobacteria,2Z2S3@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5929732_3	1051632.TPY_1505	3.224e-62	223.0	COG0745@1|root,COG0745@2|Bacteria,1TPWS@1239|Firmicutes,25AZ2@186801|Clostridia,3WDTI@538999|Clostridiales incertae sedis	186801|Clostridia	K	Transcriptional regulatory protein, C terminal	phoP	-	-	ko:K02483,ko:K07658	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
HKD2_k127_5929732_1	1120973.AQXL01000107_gene2002	1.309e-69	258.0	COG5002@1|root,COG5002@2|Bacteria,1TQ1H@1239|Firmicutes,4HA52@91061|Bacilli,27ANM@186823|Alicyclobacillaceae	91061|Bacilli	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	vicK	-	2.7.13.3	ko:K07652	ko02020,map02020	M00459	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_9
HKD2_k127_5929732_5	765911.Thivi_0270	1.973e-42	177.0	COG1216@1|root,COG1216@2|Bacteria,1N5DV@1224|Proteobacteria,1T4CS@1236|Gammaproteobacteria,1WZQU@135613|Chromatiales	135613|Chromatiales	S	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HKD2_k127_5929732_9	553184.ATORI0001_1331	5.537e-18	86.0	COG0590@1|root,COG0590@2|Bacteria,2IM3Z@201174|Actinobacteria,4CVMJ@84998|Coriobacteriia	84998|Coriobacteriia	F	Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)	tadA	-	3.5.4.33	ko:K11991	-	-	R10223	RC00477	ko00000,ko01000,ko03016	-	-	-	MafB19-deam
HKD2_k127_5984225_2	471855.Shel_21370	1.185e-96	329.0	COG0587@1|root,COG0587@2|Bacteria,2GJ1P@201174|Actinobacteria,4CV21@84998|Coriobacteriia	84998|Coriobacteriia	L	DNA polymerase III alpha subunit	-	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
HKD2_k127_5984225_0	479437.Elen_1079	4.28e-144	469.0	COG0141@1|root,COG0141@2|Bacteria,2GKKA@201174|Actinobacteria,4CURH@84998|Coriobacteriia	84998|Coriobacteriia	E	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine	hisD	-	1.1.1.23	ko:K00013	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01158,R01163,R03012	RC00099,RC00242,RC00463	ko00000,ko00001,ko00002,ko01000	-	-	-	Histidinol_dh
HKD2_k127_5984225_1	1034345.CAEM01000014_gene137	1.895e-126	415.0	COG0079@1|root,COG0079@2|Bacteria,2GJ9W@201174|Actinobacteria,4CV62@84998|Coriobacteriia	84998|Coriobacteriia	E	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily	hisC	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
HKD2_k127_5984225_3	502558.EGYY_20050	1.812e-75	258.0	COG0131@1|root,COG0131@2|Bacteria,2GKMD@201174|Actinobacteria,4CUNW@84998|Coriobacteriia	84998|Coriobacteriia	E	Imidazoleglycerol-phosphate dehydratase	hisB	-	4.2.1.19	ko:K01693	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R03457	RC00932	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPD
HKD2_k127_6124481_1	644282.Deba_0692	1.755e-174	562.0	COG2070@1|root,COG2070@2|Bacteria,1QZ4T@1224|Proteobacteria,43CFR@68525|delta/epsilon subdivisions,2X7QT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Conserved region in glutamate synthase	-	-	-	-	-	-	-	-	-	-	-	-	Glu_synthase
HKD2_k127_6124481_0	795359.TOPB45_1257	1.373e-194	617.0	COG0174@1|root,COG0174@2|Bacteria,2GH5N@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	E	Glutamine synthetase, catalytic domain	-	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
HKD2_k127_6124481_2	747365.Thena_0039	2.129e-67	240.0	COG0491@1|root,COG0491@2|Bacteria,1TT3D@1239|Firmicutes,24BV1@186801|Clostridia,42G73@68295|Thermoanaerobacterales	186801|Clostridia	S	COGs COG0491 Zn-dependent hydrolase including glyoxylase	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HKD2_k127_6124481_3	235909.GK3053	1.722e-22	106.0	COG3863@1|root,COG3863@2|Bacteria,1UFTY@1239|Firmicutes	1239|Firmicutes	S	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C92
HKD2_k127_6223509_6	469378.Ccur_11630	4.698e-14	74.0	COG0302@1|root,COG0302@2|Bacteria,2GP2P@201174|Actinobacteria,4CUPM@84998|Coriobacteriia	84998|Coriobacteriia	H	GTP cyclohydrolase	folE	-	3.5.4.16	ko:K01495	ko00790,ko01100,map00790,map01100	M00126,M00841,M00842,M00843	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	-	GTP_cyclohydroI
HKD2_k127_6223509_2	1298863.AUEP01000018_gene3825	1.018e-57	212.0	COG2064@1|root,COG2064@2|Bacteria,2GK7B@201174|Actinobacteria,4DR34@85009|Propionibacteriales	201174|Actinobacteria	NU	Type II secretion system	-	-	-	ko:K12511	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
HKD2_k127_6223509_1	685727.REQ_18420	1.968e-70	270.0	COG2304@1|root,COG4965@1|root,COG2304@2|Bacteria,COG4965@2|Bacteria,2H577@201174|Actinobacteria	201174|Actinobacteria	U	Type ii secretion system	-	-	-	ko:K12510	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF,VWA_2
HKD2_k127_6223509_0	313589.JNB_18868	5.689e-170	544.0	COG4962@1|root,COG4962@2|Bacteria,2GKKJ@201174|Actinobacteria,4FE8N@85021|Intrasporangiaceae	201174|Actinobacteria	U	pilus assembly protein ATPase CpaF	flpF	-	-	ko:K02283	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
HKD2_k127_6223509_3	351607.Acel_0975	1.448e-55	211.0	COG2197@1|root,COG4963@1|root,COG2197@2|Bacteria,COG4963@2|Bacteria,2GNHI@201174|Actinobacteria,4EVMD@85013|Frankiales	201174|Actinobacteria	D	Evidence 2b Function of strongly homologous gene	flpE	-	-	ko:K02282	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	AAA_31,CbiA,ParA
HKD2_k127_6223509_5	370438.PTH_1449	2.548e-17	91.0	COG3745@1|root,COG3745@2|Bacteria,1V5FZ@1239|Firmicutes,24I7V@186801|Clostridia,262WB@186807|Peptococcaceae	186801|Clostridia	U	Flp pilus assembly protein RcpC/CpaB	-	-	-	ko:K02279	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	RcpC,SAF
HKD2_k127_6223509_4	1123288.SOV_2c07750	3.572e-25	118.0	COG4655@1|root,COG4655@2|Bacteria,1V25X@1239|Firmicutes,4H46N@909932|Negativicutes	909932|Negativicutes	S	Putative Flp pilus-assembly TadE/G-like	-	-	-	-	-	-	-	-	-	-	-	-	Tad
HKD2_k127_6223509_7	452863.Achl_2644	7.71e-14	76.0	COG4961@1|root,COG4961@2|Bacteria,2IS3K@201174|Actinobacteria	201174|Actinobacteria	U	TadE-like protein	-	-	-	-	-	-	-	-	-	-	-	-	TadE
HKD2_k127_6300958_0	1444309.JAQG01000074_gene82	4.036e-59	217.0	COG0305@1|root,COG0305@2|Bacteria,1TPCT@1239|Firmicutes,4H9Y8@91061|Bacilli,26R5G@186822|Paenibacillaceae	91061|Bacilli	L	Participates in initiation and elongation during chromosome replication	dnaB	GO:0003674,GO:0003678,GO:0003824,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0032392,GO:0032508,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051276,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C
HKD2_k127_6300958_1	742722.HMPREF9463_00043	7.917e-46	174.0	COG0359@1|root,COG0359@2|Bacteria,2IKX7@201174|Actinobacteria,4CVTT@84998|Coriobacteriia	84998|Coriobacteriia	J	Binds to the 23S rRNA	rplI	-	-	ko:K02939	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L9_C,Ribosomal_L9_N
HKD2_k127_6300958_3	1118060.CAGZ01000028_gene972	3.542e-34	134.0	COG0238@1|root,COG0238@2|Bacteria,2IQ92@201174|Actinobacteria,4CW67@84998|Coriobacteriia	84998|Coriobacteriia	J	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit	rpsR	-	-	ko:K02963	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S18
HKD2_k127_6300958_2	545694.TREPR_2684	7.753e-35	138.0	COG0629@1|root,COG0629@2|Bacteria,2J7A3@203691|Spirochaetes	203691|Spirochaetes	L	Single-stranded DNA-binding protein	ssb	-	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
HKD2_k127_6300958_4	479437.Elen_0022	3.831e-30	127.0	COG0360@1|root,COG0360@2|Bacteria,2IQHD@201174|Actinobacteria,4CW8C@84998|Coriobacteriia	84998|Coriobacteriia	J	Binds together with S18 to 16S ribosomal RNA	rpsF	-	-	ko:K02990	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S6
HKD2_k127_6391399_10	696369.KI912183_gene1022	2.099e-109	368.0	COG2897@1|root,COG2897@2|Bacteria,1TS7E@1239|Firmicutes,24CNW@186801|Clostridia,266YB@186807|Peptococcaceae	186801|Clostridia	M	Rhodanese Homology Domain	-	-	2.8.1.11	ko:K21028	ko04122,map04122	-	R07461	-	ko00000,ko00001,ko01000	-	-	-	Rhodanese
HKD2_k127_6391399_13	1410668.JNKC01000004_gene161	1.274e-90	317.0	COG1732@1|root,COG1732@2|Bacteria,1TQ7D@1239|Firmicutes,248A1@186801|Clostridia,36DBY@31979|Clostridiaceae	186801|Clostridia	P	glycine, betaine	-	-	-	ko:K05845	ko02010,map02010	M00209	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	OpuAC
HKD2_k127_6391399_19	1367847.JCM7686_1751	5.234e-57	213.0	COG1174@1|root,COG1174@2|Bacteria,1MXA1@1224|Proteobacteria,2TUNH@28211|Alphaproteobacteria,2PWG7@265|Paracoccus	28211|Alphaproteobacteria	E	Binding-protein-dependent transport system inner membrane component	yehY	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0015695,GO:0015696,GO:0015697,GO:0015838,GO:0016020,GO:0031460,GO:0044464,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944,GO:0072337	-	ko:K05846	ko02010,map02010	M00209	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	BPD_transp_1
HKD2_k127_6391399_12	1489678.RDMS_08785	3.178e-92	329.0	COG1125@1|root,COG1125@2|Bacteria,1WJN3@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	COGs COG1125 ABC-type proline glycine betaine transport systems ATPase components	-	-	-	ko:K05847	ko02010,map02010	M00209	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	ABC_tran,CBS
HKD2_k127_6391399_25	660470.Theba_2465	4.47e-44	180.0	COG1174@1|root,COG1174@2|Bacteria,2GCTE@200918|Thermotogae	2|Bacteria	U	PFAM Binding-protein-dependent transport system inner membrane component	yehW	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0015695,GO:0015696,GO:0015697,GO:0015838,GO:0016020,GO:0031460,GO:0044464,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944,GO:0072337	-	ko:K05846	ko02010,map02010	M00209	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	iEC042_1314.EC042_2361,iECUMN_1333.ECUMN_2462	BPD_transp_1
HKD2_k127_6391399_32	388413.ALPR1_21184	4.631e-25	123.0	COG1404@1|root,COG3210@1|root,COG3291@1|root,COG1404@2|Bacteria,COG3210@2|Bacteria,COG3291@2|Bacteria,4NPRK@976|Bacteroidetes	976|Bacteroidetes	U	PFAM Uncharacterised BCR, COG1649	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6391399_7	58123.JOFJ01000015_gene4408	2.276e-124	432.0	COG0220@1|root,COG0220@2|Bacteria,2IEHH@201174|Actinobacteria	201174|Actinobacteria	J	tRNA (guanine-N7-)-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6391399_16	1122621.ATZA01000002_gene1735	1.55e-85	289.0	COG1028@1|root,COG1028@2|Bacteria,4NGQY@976|Bacteroidetes,1IRGR@117747|Sphingobacteriia	976|Bacteroidetes	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HKD2_k127_6391399_6	1157490.EL26_10740	1.751e-127	426.0	COG4412@1|root,COG4412@2|Bacteria,1UYZF@1239|Firmicutes,4HBRX@91061|Bacilli	91061|Bacilli	S	Immune inhibitor A peptidase M6	-	-	-	ko:K09607	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M6
HKD2_k127_6391399_27	1120949.KB903311_gene792	1.129e-33	147.0	COG1515@1|root,COG1515@2|Bacteria,2GJEZ@201174|Actinobacteria,4DCRD@85008|Micromonosporales	201174|Actinobacteria	L	DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA	nfi	-	3.1.21.7	ko:K05982	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	Endonuclease_5
HKD2_k127_6391399_8	760568.Desku_1497	3.152e-123	417.0	COG1690@1|root,COG1690@2|Bacteria,1TPJ2@1239|Firmicutes,2481V@186801|Clostridia,265QP@186807|Peptococcaceae	186801|Clostridia	S	tRNA-splicing ligase RtcB	-	-	6.5.1.3	ko:K14415	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RtcB
HKD2_k127_6391399_26	479434.Sthe_0161	1.526e-42	171.0	COG2211@1|root,COG2211@2|Bacteria,2G6UD@200795|Chloroflexi,27XXJ@189775|Thermomicrobia	189775|Thermomicrobia	G	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
HKD2_k127_6391399_0	697281.Mahau_2191	1.047e-263	835.0	COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247Q0@186801|Clostridia,42F44@68295|Thermoanaerobacterales	186801|Clostridia	V	ABC transporter, transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
HKD2_k127_6391399_1	697281.Mahau_2190	3.489e-236	746.0	COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247T8@186801|Clostridia,42FRT@68295|Thermoanaerobacterales	186801|Clostridia	P	ABC transporter, transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
HKD2_k127_6391399_31	903818.KI912268_gene909	2.657e-26	115.0	COG1846@1|root,COG1846@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	-	-	-	-	-	-	-	-	-	-	-	-	HTH_27,MarR,MarR_2
HKD2_k127_6391399_11	497965.Cyan7822_4382	2.553e-101	348.0	COG1063@1|root,COG1063@2|Bacteria,1FZZE@1117|Cyanobacteria,3KG4M@43988|Cyanothece	1117|Cyanobacteria	C	Alcohol dehydrogenase GroES domain protein	-	-	1.1.1.14	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014	R00875,R01896	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N,Shikimate_DH
HKD2_k127_6391399_20	913865.DOT_0742	6.969e-55	198.0	COG2050@1|root,COG2050@2|Bacteria,1V824@1239|Firmicutes,24HWD@186801|Clostridia,2670X@186807|Peptococcaceae	186801|Clostridia	Q	PFAM thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
HKD2_k127_6391399_18	706587.Desti_5083	2.154e-64	231.0	COG1575@1|root,COG1575@2|Bacteria,1PWVZ@1224|Proteobacteria,4349B@68525|delta/epsilon subdivisions,2X2PW@28221|Deltaproteobacteria,2MRJX@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	UbiA prenyltransferase family	-	-	2.5.1.74	ko:K02548	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R05617,R06858,R10757	RC02935,RC02936,RC03264	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
HKD2_k127_6391399_33	1385521.N803_09835	3.849e-19	93.0	COG0664@1|root,COG0664@2|Bacteria,2GMPN@201174|Actinobacteria,4FFBU@85021|Intrasporangiaceae	201174|Actinobacteria	K	transcriptional regulator	glxR	GO:0000166,GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006109,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010565,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0010675,GO:0016020,GO:0017076,GO:0019219,GO:0019222,GO:0030312,GO:0030551,GO:0030552,GO:0030554,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0032993,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043565,GO:0044212,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0062012,GO:0065007,GO:0071944,GO:0080090,GO:0097159,GO:0097367,GO:0140110,GO:1901265,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2000874,GO:2001141	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
HKD2_k127_6391399_14	1121447.JONL01000001_gene1055	3.752e-88	308.0	COG2199@1|root,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,42QMQ@68525|delta/epsilon subdivisions,2WN4S@28221|Deltaproteobacteria,2MBVJ@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	Protein of unknown function (DUF3365)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3365,GGDEF
HKD2_k127_6391399_3	479437.Elen_0603	1.263e-141	473.0	COG2812@1|root,COG3170@1|root,COG2812@2|Bacteria,COG3170@2|Bacteria,2GJKA@201174|Actinobacteria,4CUJ5@84998|Coriobacteriia	84998|Coriobacteriia	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity	dnaX	-	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNA_pol3_gamma3
HKD2_k127_6391399_30	1449126.JQKL01000060_gene1864	1.879e-26	113.0	COG0718@1|root,COG0718@2|Bacteria,1VA1S@1239|Firmicutes,24MXH@186801|Clostridia,269MU@186813|unclassified Clostridiales	186801|Clostridia	S	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection	-	-	-	ko:K09747	-	-	-	-	ko00000	-	-	-	YbaB_DNA_bd
HKD2_k127_6391399_15	146922.JOFU01000029_gene5324	2.913e-86	289.0	COG0353@1|root,COG0353@2|Bacteria,2GJY0@201174|Actinobacteria	201174|Actinobacteria	L	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO	recR	-	-	ko:K06187	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	HHH,RecR,Toprim_4
HKD2_k127_6391399_22	309799.DICTH_1983	3.458e-53	193.0	COG1014@1|root,COG1014@2|Bacteria	2|Bacteria	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	porC	-	1.2.7.1	ko:K00172	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR
HKD2_k127_6391399_28	555088.DealDRAFT_1246	1.288e-33	134.0	COG1144@1|root,COG1144@2|Bacteria,1VAAJ@1239|Firmicutes,24NFD@186801|Clostridia,42KVY@68298|Syntrophomonadaceae	186801|Clostridia	C	4Fe-4S dicluster domain	-	-	1.2.7.1	ko:K00171	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4
HKD2_k127_6391399_5	926692.AZYG01000051_gene1858	3.382e-135	445.0	COG0674@1|root,COG0674@2|Bacteria,1VS48@1239|Firmicutes,25E5U@186801|Clostridia,3WAF8@53433|Halanaerobiales	186801|Clostridia	C	PFAM Pyruvate flavodoxin ferredoxin oxidoreductase	porA	-	1.2.7.1	ko:K00169	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
HKD2_k127_6391399_9	574087.Acear_0037	6.752e-123	413.0	COG1013@1|root,COG1013@2|Bacteria,1TPF0@1239|Firmicutes,24BE5@186801|Clostridia,3WAIQ@53433|Halanaerobiales	186801|Clostridia	C	PFAM Thiamine pyrophosphate enzyme, C-terminal TPP binding domain	porB	-	1.2.7.1	ko:K00170	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
HKD2_k127_6391399_23	211165.AJLN01000112_gene44	5.587e-50	190.0	COG0226@1|root,COG0226@2|Bacteria,1G5ZG@1117|Cyanobacteria,1JMTW@1189|Stigonemataceae	1117|Cyanobacteria	P	PBP superfamily domain	-	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
HKD2_k127_6391399_17	264732.Moth_2150	1.938e-69	265.0	COG2203@1|root,COG3437@1|root,COG4936@1|root,COG2203@2|Bacteria,COG3437@2|Bacteria,COG4936@2|Bacteria,1V7YT@1239|Firmicutes,25ET2@186801|Clostridia,42JGC@68295|Thermoanaerobacterales	186801|Clostridia	T	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HD,PAS_9,PocR,SBP_bac_3
HKD2_k127_6391399_2	469378.Ccur_04060	5.471e-153	493.0	COG0527@1|root,COG0527@2|Bacteria,2GN0G@201174|Actinobacteria,4CUV3@84998|Coriobacteriia	84998|Coriobacteriia	E	Belongs to the aspartokinase family	-	-	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT
HKD2_k127_6391399_4	1384484.AEQU_1517	7.353e-141	469.0	COG0136@1|root,COG0136@2|Bacteria,2GJJ8@201174|Actinobacteria,4CUE4@84998|Coriobacteriia	84998|Coriobacteriia	E	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate	asd	-	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
HKD2_k127_6391399_21	1463936.JOJI01000050_gene5848	3.196e-54	203.0	COG0745@1|root,COG0745@2|Bacteria,2GP1I@201174|Actinobacteria	201174|Actinobacteria	T	response regulator, receiver	vicR	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
HKD2_k127_6391399_24	266117.Rxyl_3018	5.466e-48	190.0	COG5002@1|root,COG5002@2|Bacteria,2I2DU@201174|Actinobacteria,4CU3Z@84995|Rubrobacteria	84995|Rubrobacteria	T	Signal transduction histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
HKD2_k127_649922_2	1122135.KB893145_gene1804	5.062e-14	71.0	COG0049@1|root,COG0049@2|Bacteria,1MXC8@1224|Proteobacteria,2TSI8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA	rpsG	GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02992	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S7
HKD2_k127_649922_0	243231.GSU2860	1.575e-301	940.0	COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,42M4T@68525|delta/epsilon subdivisions,2WIM7@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
HKD2_k127_649922_1	933262.AXAM01000052_gene1988	1.16e-41	154.0	COG0050@1|root,COG0050@2|Bacteria,1MVC0@1224|Proteobacteria,42MWZ@68525|delta/epsilon subdivisions,2WJ2B@28221|Deltaproteobacteria,2MHTQ@213118|Desulfobacterales	28221|Deltaproteobacteria	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
HKD2_k127_6514016_0	56110.Oscil6304_5724	2.685e-97	330.0	COG1520@1|root,COG1520@2|Bacteria,1G3FV@1117|Cyanobacteria,1H71Z@1150|Oscillatoriales	1117|Cyanobacteria	S	beta-propeller repeat	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2
HKD2_k127_6514016_2	1121382.JQKG01000001_gene2290	1.249e-28	125.0	COG2120@1|root,COG2120@2|Bacteria	2|Bacteria	S	N-acetylglucosaminylinositol deacetylase activity	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
HKD2_k127_6514016_1	880072.Desac_2119	6.165e-70	253.0	COG1148@1|root,COG1148@2|Bacteria,1RB0H@1224|Proteobacteria,42QQV@68525|delta/epsilon subdivisions,2WN7E@28221|Deltaproteobacteria,2MRI3@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
HKD2_k127_6538976_12	502558.EGYY_24650	5.397e-22	98.0	COG1605@1|root,COG1605@2|Bacteria,2HDDB@201174|Actinobacteria,4CW2X@84998|Coriobacteriia	84998|Coriobacteriia	E	Chorismate mutase type II	-	-	-	-	-	-	-	-	-	-	-	-	CM_2
HKD2_k127_6538976_3	1034345.CAEM01000017_gene1600	8.281e-92	312.0	COG2876@1|root,COG2876@2|Bacteria,2I3UA@201174|Actinobacteria,4CV4Q@84998|Coriobacteriia	84998|Coriobacteriia	E	DAHP synthetase I family	aroF	-	2.5.1.54	ko:K03856	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_1
HKD2_k127_6538976_0	471855.Shel_16340	1.541e-236	753.0	COG0210@1|root,COG0210@2|Bacteria,2GISS@201174|Actinobacteria,4CUMT@84998|Coriobacteriia	84998|Coriobacteriia	L	DNA helicase	-	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
HKD2_k127_6538976_1	443254.Marpi_0250	4.474e-122	410.0	COG1227@1|root,COG3448@1|root,COG4109@1|root,COG1227@2|Bacteria,COG3448@2|Bacteria,COG4109@2|Bacteria,2GCU1@200918|Thermotogae	200918|Thermotogae	C	DHHA2	-	-	3.6.1.1	ko:K15986	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	CBS,DHH,DHHA2,DRTGG
HKD2_k127_6538976_11	1499967.BAYZ01000055_gene4861	8.503e-60	228.0	COG0586@1|root,COG0671@1|root,COG0586@2|Bacteria,COG0671@2|Bacteria	2|Bacteria	I	phosphatidate phosphatase activity	dedA	-	3.6.1.27	ko:K03975,ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2,SNARE_assoc
HKD2_k127_6538976_10	1121024.AUCD01000049_gene1547	1.352e-60	231.0	COG5002@1|root,COG5002@2|Bacteria,1TQ1H@1239|Firmicutes,4HB1B@91061|Bacilli,27G0D@186828|Carnobacteriaceae	91061|Bacilli	T	Single Cache-like	phoR	-	2.7.13.3	ko:K07636	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_8,PAS_9,sCache_like
HKD2_k127_6538976_7	42256.RradSPS_2422	3.834e-65	235.0	COG0745@1|root,COG0745@2|Bacteria,2GKFS@201174|Actinobacteria,4CU2Q@84995|Rubrobacteria	201174|Actinobacteria	K	Response regulator receiver	regX3	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009405,GO:0009889,GO:0010468,GO:0010556,GO:0010565,GO:0019216,GO:0019217,GO:0019219,GO:0019220,GO:0019222,GO:0031323,GO:0031326,GO:0044419,GO:0048583,GO:0050789,GO:0050794,GO:0051171,GO:0051174,GO:0051252,GO:0051704,GO:0060255,GO:0062012,GO:0065007,GO:0080090,GO:0080134,GO:0097159,GO:1901363,GO:1902882,GO:1903506,GO:2000112,GO:2001141	-	ko:K07776	ko02020,map02020	M00443	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
HKD2_k127_6538976_9	926569.ANT_02630	3.186e-62	228.0	COG0226@1|root,COG0226@2|Bacteria,2G7T2@200795|Chloroflexi	200795|Chloroflexi	P	TIGRFAM phosphate binding protein	pstS	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
HKD2_k127_6538976_8	1408422.JHYF01000006_gene1211	1.733e-64	232.0	COG0573@1|root,COG0573@2|Bacteria,1TSPP@1239|Firmicutes,249KQ@186801|Clostridia,36HRK@31979|Clostridiaceae	186801|Clostridia	P	probably responsible for the translocation of the substrate across the membrane	pstC	-	-	ko:K02037	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
HKD2_k127_6538976_5	1408422.JHYF01000006_gene1212	2.067e-76	267.0	COG0581@1|root,COG0581@2|Bacteria,1TP74@1239|Firmicutes,248C4@186801|Clostridia,36DCX@31979|Clostridiaceae	186801|Clostridia	P	Phosphate transport system permease protein PstA	pstA	-	-	ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1,DUF3333
HKD2_k127_6538976_4	1121926.AXWO01000035_gene4027	6.107e-90	309.0	COG1117@1|root,COG1117@2|Bacteria,2GJQ3@201174|Actinobacteria,4EXWB@85014|Glycomycetales	201174|Actinobacteria	P	ATPases associated with a variety of cellular activities	pstB	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
HKD2_k127_6538976_6	1120973.AQXL01000125_gene3150	1.387e-70	259.0	COG2120@1|root,COG2120@2|Bacteria,1TQM2@1239|Firmicutes,4HGT7@91061|Bacilli,27898@186823|Alicyclobacillaceae	91061|Bacilli	S	GlcNAc-PI de-N-acetylase	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
HKD2_k127_6538976_2	665571.STHERM_c06480	2.033e-100	331.0	COG2070@1|root,COG2070@2|Bacteria	2|Bacteria	S	nitronate monooxygenase activity	ycf23	-	1.1.1.205,1.13.12.16	ko:K00088,ko:K00459	ko00230,ko00910,ko00983,ko01100,ko01110,map00230,map00910,map00983,map01100,map01110	M00050	R00025,R01130,R08240	RC00143,RC02207,RC02541,RC02759	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	DUF561,Glu_synthase,IMPDH,NMO
HKD2_k127_6568489_6	471855.Shel_20020	6.208e-93	310.0	COG1351@1|root,COG1351@2|Bacteria,2HCNJ@201174|Actinobacteria,4CV8N@84998|Coriobacteriia	84998|Coriobacteriia	H	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant	thyX	-	2.1.1.148	ko:K03465	ko00240,ko00670,ko01100,map00240,map00670,map01100	-	R06613	RC00022,RC00332	ko00000,ko00001,ko01000	-	-	-	Thy1
HKD2_k127_6568489_23	445975.COLSTE_00697	1.249e-35	146.0	COG0254@1|root,COG0254@2|Bacteria,2HUWQ@201174|Actinobacteria,4CVW5@84998|Coriobacteriia	84998|Coriobacteriia	J	Binds the 23S rRNA	rpmE	-	-	ko:K02909	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L31
HKD2_k127_6568489_25	330214.NIDE0017	1.119e-21	97.0	COG3369@1|root,COG3369@2|Bacteria,3J1A6@40117|Nitrospirae	40117|Nitrospirae	S	Iron-binding zinc finger CDGSH type	-	-	-	-	-	-	-	-	-	-	-	-	zf-CDGSH
HKD2_k127_6568489_16	96561.Dole_0760	1.183e-49	182.0	COG3945@1|root,COG3945@2|Bacteria,1N3AR@1224|Proteobacteria,42UWM@68525|delta/epsilon subdivisions,2WQEC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM Hemerythrin HHE cation binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
HKD2_k127_6568489_3	1415779.JOMH01000001_gene2508	2.626e-115	381.0	COG1230@1|root,COG1230@2|Bacteria,1MVQB@1224|Proteobacteria,1RMR8@1236|Gammaproteobacteria,1X4D1@135614|Xanthomonadales	135614|Xanthomonadales	P	transporter	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux
HKD2_k127_6568489_22	935845.JADQ01000046_gene2391	1.977e-38	147.0	COG5646@1|root,COG5646@2|Bacteria,1V6QB@1239|Firmicutes,4HINV@91061|Bacilli,26YRN@186822|Paenibacillaceae	91061|Bacilli	S	Domain of unknown function (DU1801)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801
HKD2_k127_6568489_31	70601.3257642	3.119e-07	59.0	COG2020@1|root,arCOG03580@2157|Archaea,2Y18C@28890|Euryarchaeota,24481@183968|Thermococci	183968|Thermococci	O	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
HKD2_k127_6568489_7	926569.ANT_02360	1.796e-88	301.0	COG4221@1|root,COG4221@2|Bacteria	2|Bacteria	IQ	oxidoreductase activity	MA20_36825	-	1.1.1.401	ko:K21883	ko00051,ko01120,map00051,map01120	-	R11339	RC00089	ko00000,ko00001,ko01000	-	-	-	adh_short
HKD2_k127_6568489_1	1120972.AUMH01000007_gene1617	9.595e-175	565.0	2CA5R@1|root,2Z81H@2|Bacteria,1UYYB@1239|Firmicutes,4HA7J@91061|Bacilli	91061|Bacilli	S	Domain of unknown function (DUF4153)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4153
HKD2_k127_6568489_17	1120972.AUMH01000007_gene1618	2.194e-45	168.0	COG1695@1|root,COG1695@2|Bacteria,1VBBY@1239|Firmicutes	1239|Firmicutes	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	PadR
HKD2_k127_6568489_9	416591.Tlet_1576	3.139e-67	240.0	COG2021@1|root,COG2021@2|Bacteria	2|Bacteria	E	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine	-	-	-	ko:K16264	-	-	-	-	ko00000,ko02000	2.A.4.1	-	-	Abhydrolase_1,Abhydrolase_6
HKD2_k127_6568489_26	1196323.ALKF01000201_gene2987	2.596e-17	89.0	COG0454@1|root,COG0456@2|Bacteria,1VDT2@1239|Firmicutes,4I1FV@91061|Bacilli,275JR@186822|Paenibacillaceae	91061|Bacilli	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HKD2_k127_6568489_29	1268072.PSAB_04880	5.406e-13	72.0	COG3585@1|root,COG3585@2|Bacteria,1VEPR@1239|Firmicutes,4HR5A@91061|Bacilli,26ZSK@186822|Paenibacillaceae	91061|Bacilli	H	TOBE domain	-	-	-	-	-	-	-	-	-	-	-	-	TOBE
HKD2_k127_6568489_18	1123024.AUII01000001_gene3026	3.553e-45	172.0	COG3153@1|root,COG3153@2|Bacteria	2|Bacteria	S	transferase activity, transferring acyl groups	yhbS	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006473,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016740,GO:0016746,GO:0016747,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901564	-	ko:K03824	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_1,Acetyltransf_7,Acetyltransf_9
HKD2_k127_6568489_28	555088.DealDRAFT_0112	6.154e-14	82.0	2FJYI@1|root,34BKW@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6568489_27	380358.XALC_2127	1.795e-16	86.0	2EHW5@1|root,33BMQ@2|Bacteria,1P29Q@1224|Proteobacteria,1T710@1236|Gammaproteobacteria,1X8K7@135614|Xanthomonadales	135614|Xanthomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6568489_20	35754.JNYJ01000054_gene9836	7.892e-40	160.0	COG5646@1|root,COG5646@2|Bacteria,2IINN@201174|Actinobacteria,4DE4R@85008|Micromonosporales	201174|Actinobacteria	S	InterPro IPR014922	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801
HKD2_k127_6568489_32	391625.PPSIR1_30070	2.396e-05	53.0	2E36C@1|root,32Y63@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6568489_15	109760.SPPG_05784T0	7.674e-54	198.0	2BN73@1|root,2S1NQ@2759|Eukaryota,3A55Y@33154|Opisthokonta,3P4MH@4751|Fungi	4751|Fungi	S	Allomyces macrogynus ATCC 38327	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_10
HKD2_k127_6568489_21	562743.JH976434_gene1836	1.903e-39	157.0	2DBV7@1|root,2ZB9P@2|Bacteria,1UBN2@1239|Firmicutes,4HEYF@91061|Bacilli	91061|Bacilli	S	Domain of unknown function (DUF4386)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4386
HKD2_k127_6568489_24	1150399.AQYK01000001_gene2048	6.229e-31	126.0	COG1476@1|root,COG1476@2|Bacteria,2GQIU@201174|Actinobacteria,4FQE5@85023|Microbacteriaceae	201174|Actinobacteria	K	Helix-turn-helix domain	-	-	-	ko:K07729	-	-	-	-	ko00000,ko03000	-	-	-	HTH_3
HKD2_k127_6568489_30	345341.KUTG_01981	6.913e-09	64.0	2CBYE@1|root,32RUB@2|Bacteria,2IM4Q@201174|Actinobacteria,4E5ER@85010|Pseudonocardiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6568489_11	105425.BBPL01000104_gene1169	4.509e-58	207.0	2DM8J@1|root,32695@2|Bacteria,2I561@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6568489_5	871968.DESME_03005	4.672e-96	318.0	COG0247@1|root,COG0247@2|Bacteria,1TPAM@1239|Firmicutes,24I1E@186801|Clostridia,263YN@186807|Peptococcaceae	186801|Clostridia	C	lactate metabolic process	-	-	-	-	-	-	-	-	-	-	-	-	CCG
HKD2_k127_6568489_0	479437.Elen_1088	1.487e-179	584.0	COG1158@1|root,COG1158@2|Bacteria,2GIWY@201174|Actinobacteria,4CU9T@84998|Coriobacteriia	84998|Coriobacteriia	K	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template	rho	-	-	ko:K03628	ko03018,map03018	-	-	-	ko00000,ko00001,ko03019,ko03021	-	-	-	ATP-synt_ab,Rho_N,Rho_RNA_bind,SAP
HKD2_k127_6568489_19	906888.JCM19314_3564	2.707e-43	173.0	COG0176@1|root,COG0176@2|Bacteria,4NFVZ@976|Bacteroidetes,1HXUY@117743|Flavobacteriia,3HJS9@363408|Nonlabens	976|Bacteroidetes	G	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway	tal	-	2.2.1.2	ko:K00616,ko:K08314	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
HKD2_k127_6568489_10	1121377.KB906401_gene3425	2.45e-65	241.0	COG2074@1|root,COG2074@2|Bacteria,1WI2U@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	G	2-phosphoglycerate kinase	-	-	-	ko:K05715	-	-	R02664	RC00002,RC00017	ko00000,ko01000	-	-	-	ATP-cone
HKD2_k127_6568489_4	266117.Rxyl_1657	3.512e-105	359.0	COG2403@1|root,COG2403@2|Bacteria,2H3G5@201174|Actinobacteria	201174|Actinobacteria	F	Catalyzes the formation of cyclic 2,3-diphosphoglycerate (cDPG) by formation of an intramolecular phosphoanhydride bond at the expense of ATP	cpgS	-	-	ko:K05716	-	-	R03298	RC00900	ko00000,ko01000	-	-	-	-
HKD2_k127_6568489_8	266117.Rxyl_1658	2.947e-87	298.0	COG1409@1|root,COG1409@2|Bacteria	2|Bacteria	S	acid phosphatase activity	CP_0969	-	-	-	-	-	-	-	-	-	-	-	Metallophos,Metallophos_2
HKD2_k127_6568489_14	1121422.AUMW01000012_gene2965	1.527e-54	204.0	COG0616@1|root,COG0616@2|Bacteria,1TRQW@1239|Firmicutes,24BP1@186801|Clostridia,261G2@186807|Peptococcaceae	186801|Clostridia	OU	signal peptide peptidase SppA, 36K type	sppA	-	-	ko:K04773	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S49
HKD2_k127_6568489_13	266117.Rxyl_3124	1.504e-55	205.0	COG0083@1|root,COG0083@2|Bacteria,2GKIW@201174|Actinobacteria,4CQEJ@84995|Rubrobacteria	84995|Rubrobacteria	E	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate	thrB	-	2.7.1.39	ko:K00872	ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230	M00018	R01771	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
HKD2_k127_6568489_2	479437.Elen_0280	5.776e-150	485.0	COG0460@1|root,COG0460@2|Bacteria,2GIX9@201174|Actinobacteria,4CUZW@84998|Coriobacteriia	84998|Coriobacteriia	E	homoserine dehydrogenase	-	-	1.1.1.3	ko:K00003	ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00017,M00018	R01773,R01775	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,Homoserine_dh,NAD_binding_3
HKD2_k127_6568489_12	469378.Ccur_01670	3.232e-57	201.0	COG0019@1|root,COG0019@2|Bacteria,2GKAI@201174|Actinobacteria,4CV4B@84998|Coriobacteriia	84998|Coriobacteriia	E	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine	lysA	-	4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
HKD2_k127_675376_3	485916.Dtox_1737	5.868e-66	236.0	COG0288@1|root,COG0288@2|Bacteria,1V1YB@1239|Firmicutes,24GMG@186801|Clostridia,261GG@186807|Peptococcaceae	186801|Clostridia	P	Reversible hydration of carbon dioxide	cynT	-	4.2.1.1	ko:K01673	ko00910,map00910	-	R00132,R10092	RC02807	ko00000,ko00001,ko01000	-	-	-	Pro_CA
HKD2_k127_675376_1	479437.Elen_2016	1.974e-200	634.0	COG0174@1|root,COG0174@2|Bacteria,2GJ2I@201174|Actinobacteria,4CUPB@84998|Coriobacteriia	84998|Coriobacteriia	E	Glutamine synthetase, beta-grasp domain	-	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
HKD2_k127_675376_4	479437.Elen_2015	2.097e-57	207.0	COG0745@1|root,COG0745@2|Bacteria,2GJGU@201174|Actinobacteria,4CUTE@84998|Coriobacteriia	84998|Coriobacteriia	K	Transcriptional regulatory protein	-	-	-	-	-	-	-	-	-	-	-	-	Trans_reg_C
HKD2_k127_675376_5	670487.Ocepr_1200	1.273e-25	115.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_11,Methyltransf_31
HKD2_k127_675376_0	471855.Shel_12990	1.007e-258	832.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,2GJY2@201174|Actinobacteria,4CUSF@84998|Coriobacteriia	84998|Coriobacteriia	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A
HKD2_k127_675376_6	1089545.KB913037_gene1203	6.474e-23	115.0	COG3291@1|root,COG3386@1|root,COG3291@2|Bacteria,COG3386@2|Bacteria,2GNGF@201174|Actinobacteria,4E83J@85010|Pseudonocardiales	201174|Actinobacteria	G	PFAM Copper binding proteins, plastocyanin azurin family	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_2,Copper-bind,DUF1080
HKD2_k127_675376_2	1125712.HMPREF1316_1038	4.662e-72	250.0	COG0539@1|root,COG0539@2|Bacteria,2GJAK@201174|Actinobacteria,4CV59@84998|Coriobacteriia	84998|Coriobacteriia	J	Ribosomal protein S1	rpsA	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
HKD2_k127_6769225_3	1227349.C170_12035	3.304e-56	215.0	COG2843@1|root,COG2843@2|Bacteria,1UCFI@1239|Firmicutes,4HE6D@91061|Bacilli,26RGF@186822|Paenibacillaceae	91061|Bacilli	M	enzyme of poly-gamma-glutamate biosynthesis (Capsule formation)	capA	-	-	ko:K07282	-	-	-	-	ko00000	-	-	-	PGA_cap
HKD2_k127_6769225_6	203119.Cthe_0317	3.545e-16	87.0	2C9IH@1|root,32RPC@2|Bacteria,1VBJ7@1239|Firmicutes,24NU4@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6769225_4	1232410.KI421421_gene3311	3.32e-48	185.0	COG0248@1|root,COG0248@2|Bacteria,1MV35@1224|Proteobacteria,42NIH@68525|delta/epsilon subdivisions,2WN60@28221|Deltaproteobacteria,43UE3@69541|Desulfuromonadales	28221|Deltaproteobacteria	FP	metal-dependent phosphohydrolase, HD sub domain	gppA-2	-	3.6.1.11,3.6.1.40	ko:K01524	ko00230,map00230	-	R03409	RC00002	ko00000,ko00001,ko01000	-	-	-	HD,Ppx-GppA
HKD2_k127_6769225_1	156889.Mmc1_0146	1.914e-125	408.0	COG2326@1|root,COG2326@2|Bacteria,1MVE2@1224|Proteobacteria,2TSU8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	polyphosphate kinase	-	-	2.7.4.1	ko:K22468	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PPK2
HKD2_k127_6769225_0	326427.Cagg_3471	2.114e-232	739.0	COG0855@1|root,COG0855@2|Bacteria,2G68J@200795|Chloroflexi,374Y0@32061|Chloroflexia	32061|Chloroflexia	H	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)	ppk	-	2.7.4.1	ko:K00937	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PP_kinase,PP_kinase_C,PP_kinase_N
HKD2_k127_6769225_2	649638.Trad_2090	1.625e-90	316.0	COG2133@1|root,COG2133@2|Bacteria,1WJQY@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	G	PFAM Glucose Sorbosone dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	GSDH
HKD2_k127_6769225_5	386456.JQKN01000011_gene729	9.861e-20	91.0	arCOG03597@1|root,arCOG03597@2157|Archaea	2157|Archaea	S	Protein of unknown function (DUF2769)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2769
HKD2_k127_6805632_0	204536.SULAZ_1085	2.495e-207	661.0	COG0518@1|root,COG0519@1|root,COG0518@2|Bacteria,COG0519@2|Bacteria,2G3NT@200783|Aquificae	200783|Aquificae	F	Catalyzes the synthesis of GMP from XMP	guaA	GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase,GMP_synt_C,NAD_synthase
HKD2_k127_6805632_1	338963.Pcar_1217	1.598e-202	642.0	COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,1MUJM@1224|Proteobacteria,42M2M@68525|delta/epsilon subdivisions,2WJ5H@28221|Deltaproteobacteria,43RY6@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	IMP dehydrogenase / GMP reductase domain	guaB	-	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,IMPDH,NMO
HKD2_k127_6805632_2	290397.Adeh_2353	2.36e-57	204.0	COG0663@1|root,COG0663@2|Bacteria,1RD76@1224|Proteobacteria,42MR0@68525|delta/epsilon subdivisions,2WP23@28221|Deltaproteobacteria,2Z0GF@29|Myxococcales	28221|Deltaproteobacteria	S	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily	yrdA	-	-	-	-	-	-	-	-	-	-	-	Hexapep
HKD2_k127_6805632_3	477974.Daud_1172	3.728e-47	178.0	COG1160@1|root,COG1160@2|Bacteria,1TPNM@1239|Firmicutes,2493T@186801|Clostridia,2602V@186807|Peptococcaceae	186801|Clostridia	S	GTPase that plays an essential role in the late steps of ribosome biogenesis	der	-	-	ko:K03977	-	-	-	-	ko00000,ko03009	-	-	-	KH_dom-like,MMR_HSR1
HKD2_k127_6824017_2	1123508.JH636440_gene2748	2.758e-11	76.0	COG3509@1|root,COG3509@2|Bacteria,2J0RK@203682|Planctomycetes	203682|Planctomycetes	Q	depolymerase	-	-	-	ko:K03932	-	-	-	-	ko00000	-	CE1	-	Esterase_phd
HKD2_k127_6824017_0	665571.STHERM_c03300	4.701e-42	178.0	COG3391@1|root,COG3391@2|Bacteria,2J5ZD@203691|Spirochaetes	203691|Spirochaetes	S	40-residue YVTN family beta-propeller	-	-	-	-	-	-	-	-	-	-	-	-	Lactonase
HKD2_k127_6824017_1	765420.OSCT_1466	1.731e-21	102.0	COG1028@1|root,COG1028@2|Bacteria,2G9VV@200795|Chloroflexi,377FY@32061|Chloroflexia	32061|Chloroflexia	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HKD2_k127_70310_3	1232436.CAPF01000014_gene750	3.701e-86	292.0	COG0761@1|root,COG0761@2|Bacteria,2GIZ7@201174|Actinobacteria,4CUET@84998|Coriobacteriia	84998|Coriobacteriia	IM	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis	ispH	-	1.17.7.4	ko:K03527	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05884,R08210	RC01137,RC01487	ko00000,ko00001,ko00002,ko01000	-	-	-	LYTB
HKD2_k127_70310_1	1232436.CAPF01000014_gene751	5.228e-93	332.0	COG1625@1|root,COG1625@2|Bacteria,2H3RR@201174|Actinobacteria,4CUHT@84998|Coriobacteriia	84998|Coriobacteriia	C	FeS-containing Cyanobacterial-specific oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DUF512
HKD2_k127_70310_0	1235794.C811_00310	1.781e-179	574.0	COG1160@1|root,COG1160@2|Bacteria,2GJ8J@201174|Actinobacteria,4CUAJ@84998|Coriobacteriia	84998|Coriobacteriia	S	GTPase that plays an essential role in the late steps of ribosome biogenesis	der	-	-	ko:K03977	-	-	-	-	ko00000,ko03009	-	-	-	KH_dom-like,MMR_HSR1
HKD2_k127_70310_7	756272.Plabr_4548	3.995e-31	136.0	COG0344@1|root,COG0344@2|Bacteria,2J0DJ@203682|Planctomycetes	203682|Planctomycetes	I	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP	plsY	-	2.3.1.15	ko:K08591	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	DUF4149,G3P_acyltransf
HKD2_k127_70310_2	742818.HMPREF9451_00818	9.688e-93	317.0	COG0240@1|root,COG0240@2|Bacteria,2GJSD@201174|Actinobacteria,4CV3K@84998|Coriobacteriia	84998|Coriobacteriia	I	Glycerol-3-phosphate dehydrogenase	gpsA	-	1.1.1.94	ko:K00057	ko00564,ko01110,map00564,map01110	-	R00842,R00844	RC00029	ko00000,ko00001,ko01000	-	-	-	NAD_Gly3P_dh_C,NAD_Gly3P_dh_N
HKD2_k127_70310_5	1430331.EP10_16745	2.484e-67	246.0	COG0036@1|root,COG0036@2|Bacteria,1TQK8@1239|Firmicutes,4H9RW@91061|Bacilli,1WE4J@129337|Geobacillus	91061|Bacilli	G	Ribulose-phosphate 3 epimerase family	rpe	GO:0003674,GO:0003824,GO:0004750,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009052,GO:0009056,GO:0009117,GO:0009987,GO:0016052,GO:0016853,GO:0016854,GO:0016857,GO:0019321,GO:0019323,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046483,GO:0046496,GO:0046872,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564,GO:1901575	5.1.3.1	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
HKD2_k127_70310_4	519989.ECTPHS_05866	6.194e-74	264.0	COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,1MUWT@1224|Proteobacteria,1RN2M@1236|Gammaproteobacteria,1WVVQ@135613|Chromatiales	135613|Chromatiales	H	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate	ribD	-	1.1.1.193,3.5.4.26	ko:K11752	ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024	M00125	R03458,R03459	RC00204,RC00933	ko00000,ko00001,ko00002,ko01000	-	-	-	RibD_C,dCMP_cyt_deam_1
HKD2_k127_70310_6	1232410.KI421413_gene683	4.106e-51	202.0	COG0307@1|root,COG0307@2|Bacteria,1MUMB@1224|Proteobacteria,42QT1@68525|delta/epsilon subdivisions,2WNK6@28221|Deltaproteobacteria,43UI4@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Lumazine binding domain	ribE	-	2.5.1.9	ko:K00793	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00066	RC00958,RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	Lum_binding
HKD2_k127_7044125_5	479437.Elen_1306	3.834e-80	276.0	COG0192@1|root,COG0192@2|Bacteria,2GJ4U@201174|Actinobacteria,4CU9D@84998|Coriobacteriia	84998|Coriobacteriia	H	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme	metK	-	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
HKD2_k127_7044125_12	1238425.J07HQW2_02696	7.76e-06	55.0	COG3431@1|root,arCOG06422@2157|Archaea,2XZNV@28890|Euryarchaeota,23X3C@183963|Halobacteria	183963|Halobacteria	S	Phosphate-starvation-inducible E	-	-	-	-	-	-	-	-	-	-	-	-	PsiE
HKD2_k127_7044125_8	1121106.JQKB01000012_gene4682	3.24e-33	143.0	COG0265@1|root,COG0823@1|root,COG2931@1|root,COG0265@2|Bacteria,COG0823@2|Bacteria,COG2931@2|Bacteria	2|Bacteria	Q	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	ko:K08372	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	HemolysinCabind,NACHT,PDZ_2,Trypsin_2,VCBS
HKD2_k127_7044125_2	649764.HMPREF0762_00103	4.203e-185	591.0	COG0008@1|root,COG0008@2|Bacteria,2GJJS@201174|Actinobacteria,4CV46@84998|Coriobacteriia	84998|Coriobacteriia	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
HKD2_k127_7044125_0	1187851.A33M_2297	3.575e-266	829.0	COG0008@1|root,COG0008@2|Bacteria,1MUC8@1224|Proteobacteria,2TRKX@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	Glutaminyl-tRNA synthetase	glnS	-	6.1.1.18	ko:K01886	ko00970,ko01100,map00970,map01100	M00359,M00360	R03652	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1c,tRNA-synt_1c_C
HKD2_k127_7044125_9	509191.AEDB02000022_gene2925	6.633e-10	72.0	COG1404@1|root,COG1404@2|Bacteria,1TQ2M@1239|Firmicutes,24CD5@186801|Clostridia,3WIT1@541000|Ruminococcaceae	186801|Clostridia	O	Subtilase family	-	-	-	ko:K13274,ko:K14645	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002,ko03110	-	-	-	Big_2,Peptidase_S8,SLH
HKD2_k127_7044125_3	593750.Metfor_0883	9.659e-170	555.0	COG1239@1|root,COG1240@1|root,arCOG00438@2157|Archaea,arCOG06472@2157|Archaea,2XUP4@28890|Euryarchaeota,2N9BN@224756|Methanomicrobia	224756|Methanomicrobia	H	AAA domain (dynein-related subfamily)	-	-	6.6.1.1	ko:K03404,ko:K03405	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R03877	RC01012	ko00000,ko00001,ko01000	-	-	-	AAA_5,Mg_chelatase,VWA_2
HKD2_k127_7044125_6	42256.RradSPS_0254	2.27e-65	244.0	COG0322@1|root,COG2176@1|root,COG0322@2|Bacteria,COG2176@2|Bacteria,2GMC0@201174|Actinobacteria,4CQ82@84995|Rubrobacteria	84995|Rubrobacteria	L	EXOIII	-	-	2.7.7.7	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	GIY-YIG,RNase_T,UVR
HKD2_k127_7044125_7	941449.dsx2_3393	4.191e-53	203.0	COG0648@1|root,COG0648@2|Bacteria,1MX4Y@1224|Proteobacteria,42MYE@68525|delta/epsilon subdivisions,2WJC7@28221|Deltaproteobacteria,2M8JK@213115|Desulfovibrionales	28221|Deltaproteobacteria	L	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin	nfo	GO:0003674,GO:0003824,GO:0003906,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008081,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0033554,GO:0034641,GO:0042578,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360	3.1.21.2	ko:K01151	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AP_endonuc_2
HKD2_k127_7044125_4	661087.HMPREF1008_01381	3.38e-113	381.0	COG0389@1|root,COG0389@2|Bacteria,2GKBI@201174|Actinobacteria,4CUNP@84998|Coriobacteriia	84998|Coriobacteriia	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	dinB	-	2.7.7.7	ko:K02346	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C,IMS_HHH
HKD2_k127_7044125_1	643648.Slip_2141	7.864e-226	740.0	COG0587@1|root,COG0587@2|Bacteria,1TPYG@1239|Firmicutes,247U0@186801|Clostridia,42JI1@68298|Syntrophomonadaceae	186801|Clostridia	L	TIGRFAM DNA polymerase III, alpha subunit	dnaE	-	2.7.7.7	ko:K02337,ko:K14162	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
HKD2_k127_7048122_0	243231.GSU2860	1.029e-298	931.0	COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,42M4T@68525|delta/epsilon subdivisions,2WIM7@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
HKD2_k127_7048122_1	552531.BIF_01972	1.682e-12	68.0	COG0050@1|root,COG0050@2|Bacteria,2GK4T@201174|Actinobacteria,4CYY7@85004|Bifidobacteriales	201174|Actinobacteria	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	GO:0001666,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0008150,GO:0009628,GO:0010035,GO:0010038,GO:0010039,GO:0016020,GO:0019899,GO:0030312,GO:0035375,GO:0036293,GO:0040007,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0070482,GO:0071944	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
HKD2_k127_7315761_4	370438.PTH_1819	1.391e-25	111.0	COG0597@1|root,COG0597@2|Bacteria,1VA9R@1239|Firmicutes,24QPP@186801|Clostridia,262DS@186807|Peptococcaceae	186801|Clostridia	MU	This protein specifically catalyzes the removal of signal peptides from prolipoproteins	lspA	-	3.4.23.36	ko:K03101	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_A8
HKD2_k127_7315761_3	1256908.HMPREF0373_00886	8.182e-37	152.0	COG0682@1|root,COG0682@2|Bacteria,1TPAK@1239|Firmicutes,24BK7@186801|Clostridia,25ZSS@186806|Eubacteriaceae	186801|Clostridia	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	lgt	-	-	ko:K13292	-	-	-	-	ko00000,ko01000	-	-	-	LGT
HKD2_k127_7315761_1	700015.Corgl_1016	9.818e-102	353.0	COG0564@1|root,COG0564@2|Bacteria,2GIY1@201174|Actinobacteria,4CUMJ@84998|Coriobacteriia	84998|Coriobacteriia	J	Responsible for synthesis of pseudouridine from uracil	-	-	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
HKD2_k127_7315761_0	471855.Shel_00330	5.135e-104	343.0	COG0745@1|root,COG0745@2|Bacteria,2GMP1@201174|Actinobacteria,4CYGQ@84998|Coriobacteriia	84998|Coriobacteriia	K	response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
HKD2_k127_7315761_2	1034345.CAEM01000008_gene1262	7.354e-90	321.0	COG0642@1|root,COG2205@2|Bacteria,2I2QY@201174|Actinobacteria,4CUCM@84998|Coriobacteriia	84998|Coriobacteriia	T	ATPase histidine kinase DNA gyrase B HSP90 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
HKD2_k127_757011_0	1280706.AUJE01000014_gene1714	8.568e-115	384.0	COG0452@1|root,COG0452@2|Bacteria,1TPP3@1239|Firmicutes,4H27H@909932|Negativicutes	909932|Negativicutes	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	coaBC	-	4.1.1.36,6.3.2.5	ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	DFP,Flavoprotein
HKD2_k127_757011_1	644966.Tmar_1485	2.508e-54	214.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,1TSSC@1239|Firmicutes,248I6@186801|Clostridia,3WDC4@538999|Clostridiales incertae sedis	186801|Clostridia	C	TIGRFAM 2-oxoacid acceptor oxidoreductase, alpha subunit	korA	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR,POR_N
HKD2_k127_763793_7	246199.CUS_4404	1.645e-11	76.0	COG0515@1|root,COG2815@1|root,COG0515@2|Bacteria,COG2815@2|Bacteria,1TP3F@1239|Firmicutes,24BJ8@186801|Clostridia,3WS4U@541000|Ruminococcaceae	186801|Clostridia	KLT	Protein tyrosine kinase	-	-	-	-	-	-	-	-	-	-	-	-	FHA,PASTA,PDZ_2,Pkinase,YARHG
HKD2_k127_763793_6	436229.JOEH01000003_gene1813	1.609e-12	71.0	COG2331@1|root,COG2331@2|Bacteria,2IQHE@201174|Actinobacteria,2NJBB@228398|Streptacidiphilus	201174|Actinobacteria	S	Putative regulatory protein	-	-	-	-	-	-	-	-	-	-	-	-	Zn-ribbon_8
HKD2_k127_763793_2	484770.UFO1_0462	1.414e-107	357.0	COG1494@1|root,COG1494@2|Bacteria,1TP0D@1239|Firmicutes,4H22D@909932|Negativicutes	909932|Negativicutes	G	fructose-1,6-bisphosphatase	glpX	-	3.1.3.11	ko:K02446	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200	M00003,M00165,M00167	R00762,R04780	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FBPase_glpX
HKD2_k127_763793_3	479437.Elen_1711	1.327e-74	273.0	COG0144@1|root,COG0781@1|root,COG0144@2|Bacteria,COG0781@2|Bacteria,2GM21@201174|Actinobacteria,4CVCM@84998|Coriobacteriia	84998|Coriobacteriia	JK	Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family	-	-	2.1.1.176	ko:K03500	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltr_RsmB-F,NusB
HKD2_k127_763793_4	1121866.AUGK01000004_gene82	2.588e-71	254.0	COG0223@1|root,COG0223@2|Bacteria,2GKH5@201174|Actinobacteria,4CU92@84998|Coriobacteriia	84998|Coriobacteriia	J	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus	fmt	-	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	-	Formyl_trans_C,Formyl_trans_N
HKD2_k127_763793_5	266117.Rxyl_1468	1.761e-34	137.0	COG0242@1|root,COG0242@2|Bacteria,2GJ87@201174|Actinobacteria,4CQ1V@84995|Rubrobacteria	84995|Rubrobacteria	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions	def	-	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	Pep_deformylase
HKD2_k127_763793_0	562970.Btus_1420	2.976e-174	582.0	COG1198@1|root,COG1198@2|Bacteria,1TNYB@1239|Firmicutes,4H9WW@91061|Bacilli,27835@186823|Alicyclobacillaceae	91061|Bacilli	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006270,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0042623,GO:0043138,GO:0043140,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,ResIII
HKD2_k127_763793_1	1232436.CAPF01000013_gene789	7.838e-130	418.0	COG0192@1|root,COG0192@2|Bacteria,2GJ4U@201174|Actinobacteria,4CU9D@84998|Coriobacteriia	84998|Coriobacteriia	H	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme	metK	-	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
HKD2_k127_764143_0	502558.EGYY_21750	2.485e-221	699.0	COG0272@1|root,COG0272@2|Bacteria,2GJUY@201174|Actinobacteria,4CURR@84998|Coriobacteriia	84998|Coriobacteriia	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	-	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2
HKD2_k127_764143_2	926550.CLDAP_19390	6.441e-70	245.0	COG1136@1|root,COG1136@2|Bacteria,2G69N@200795|Chloroflexi	200795|Chloroflexi	P	Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD2_k127_764143_5	292459.STH607	6.709e-45	179.0	COG0577@1|root,COG0577@2|Bacteria,1TUYK@1239|Firmicutes,24DGM@186801|Clostridia	186801|Clostridia	V	ABC-type transport system involved in lipoprotein release permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HKD2_k127_764143_8	1443122.Z958_08100	6.817e-08	65.0	COG1266@1|root,COG1266@2|Bacteria,1V26Z@1239|Firmicutes	1239|Firmicutes	S	protease	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
HKD2_k127_764143_12	596152.DesU5LDRAFT_3884	1.59e-05	57.0	COG1149@1|root,COG1149@2|Bacteria,1MVPB@1224|Proteobacteria,42MJ5@68525|delta/epsilon subdivisions,2WJ9M@28221|Deltaproteobacteria,2M7TE@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Cobyrinic acid ac-diamide synthase	-	-	-	-	-	-	-	-	-	-	-	-	CbiA,Fer4
HKD2_k127_764143_9	485913.Krac_10615	5.516e-07	62.0	COG1266@1|root,COG1266@2|Bacteria,2G9H5@200795|Chloroflexi	200795|Chloroflexi	S	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
HKD2_k127_764143_3	926550.CLDAP_19390	1.536e-69	248.0	COG1136@1|root,COG1136@2|Bacteria,2G69N@200795|Chloroflexi	200795|Chloroflexi	P	Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD2_k127_764143_4	292459.STH607	1.108e-51	198.0	COG0577@1|root,COG0577@2|Bacteria,1TUYK@1239|Firmicutes,24DGM@186801|Clostridia	186801|Clostridia	V	ABC-type transport system involved in lipoprotein release permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HKD2_k127_764143_7	926554.KI912640_gene1380	4.402e-20	98.0	COG1309@1|root,COG1309@2|Bacteria	2|Bacteria	K	transcriptional regulator	ttgR	-	-	-	-	-	-	-	-	-	-	-	TetR_N,WHG
HKD2_k127_764143_6	42256.RradSPS_0717	3.052e-21	98.0	COG0721@1|root,COG0721@2|Bacteria,2IQJN@201174|Actinobacteria,4CQK8@84995|Rubrobacteria	84995|Rubrobacteria	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatC	-	6.3.5.6,6.3.5.7	ko:K02435	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Glu-tRNAGln
HKD2_k127_764143_1	760568.Desku_1682	1.034e-171	555.0	COG0154@1|root,COG0154@2|Bacteria,1TP0C@1239|Firmicutes,24911@186801|Clostridia,2613E@186807|Peptococcaceae	186801|Clostridia	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
HKD2_k127_764143_11	936573.HMPREF1147_2221	2.988e-06	59.0	COG0392@1|root,COG0392@2|Bacteria,1TSAD@1239|Firmicutes,4H28G@909932|Negativicutes	909932|Negativicutes	S	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms	mprF	-	-	ko:K07027	-	-	-	-	ko00000,ko02000	4.D.2	-	-	LPG_synthase_TM
HKD2_k127_764143_10	1121422.AUMW01000008_gene476	1.711e-06	61.0	COG5001@1|root,COG5001@2|Bacteria	2|Bacteria	T	cyclic-guanylate-specific phosphodiesterase activity	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS,PAS_9,Response_reg
HKD2_k127_7667607_1	931626.Awo_c24490	7.234e-206	661.0	COG3808@1|root,COG3808@2|Bacteria,1TNZI@1239|Firmicutes,248KS@186801|Clostridia,25V7G@186806|Eubacteriaceae	186801|Clostridia	C	Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na( ) movement across the membrane	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
HKD2_k127_7667607_2	502558.EGYY_16910	1.197e-121	399.0	COG0232@1|root,COG0232@2|Bacteria,2GJ8F@201174|Actinobacteria,4CVBJ@84998|Coriobacteriia	84998|Coriobacteriia	F	Belongs to the dGTPase family. Type 2 subfamily	-	-	3.1.5.1	ko:K01129	ko00230,map00230	-	R01856	RC00017	ko00000,ko00001,ko01000	-	-	-	HD,HD_assoc
HKD2_k127_7667607_0	471855.Shel_11050	8.35e-244	764.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,2GK73@201174|Actinobacteria,4CUB1@84998|Coriobacteriia	84998|Coriobacteriia	G	Belongs to the PEP-utilizing enzyme family	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
HKD2_k127_7673918_8	1267005.KB911258_gene507	6.021e-148	475.0	COG0559@1|root,COG0559@2|Bacteria,1MU25@1224|Proteobacteria,2TSDS@28211|Alphaproteobacteria,3N70V@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	livH	GO:0003333,GO:0003674,GO:0005215,GO:0005304,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015173,GO:0015175,GO:0015179,GO:0015188,GO:0015190,GO:0015192,GO:0015238,GO:0015318,GO:0015658,GO:0015711,GO:0015801,GO:0015803,GO:0015804,GO:0015807,GO:0015818,GO:0015820,GO:0015823,GO:0015829,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0042221,GO:0042493,GO:0043090,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0089718,GO:0098655,GO:0098656,GO:0098657,GO:0098713,GO:0098739,GO:1902475,GO:1903714,GO:1903785,GO:1903825,GO:1905039	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HKD2_k127_7673918_7	1502851.FG93_03954	2.491e-164	529.0	COG4177@1|root,COG4177@2|Bacteria,1MV66@1224|Proteobacteria,2TSJQ@28211|Alphaproteobacteria,3JQQ9@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	livM	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2,DUF3382
HKD2_k127_7673918_11	426355.Mrad2831_2251	8.654e-117	400.0	COG0411@1|root,COG0411@2|Bacteria,1MUTY@1224|Proteobacteria,2TQK1@28211|Alphaproteobacteria,1JRX6@119045|Methylobacteriaceae	28211|Alphaproteobacteria	E	PFAM ABC transporter	braF	GO:0003333,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008150,GO:0015711,GO:0015803,GO:0015804,GO:0015807,GO:0015808,GO:0015818,GO:0015829,GO:0015849,GO:0015893,GO:0032328,GO:0034220,GO:0042221,GO:0042493,GO:0042940,GO:0042941,GO:0043090,GO:0046942,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0089718,GO:0098655,GO:0098656,GO:0098657,GO:0098739,GO:1902475,GO:1903714,GO:1903785,GO:1903805,GO:1903806,GO:1903825,GO:1905039	3.5.4.44	ko:K01995,ko:K15783	ko00260,ko01100,ko02010,ko02024,map00260,map01100,map02010,map02024	M00237	R09800	RC02661	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
HKD2_k127_7673918_12	1510531.JQJJ01000008_gene3409	7.339e-109	357.0	COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,2TR61@28211|Alphaproteobacteria,3JUTM@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	ABC transporter	livF	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
HKD2_k127_7673918_30	1411123.JQNH01000001_gene990	7.776e-25	110.0	2C07J@1|root,32SWS@2|Bacteria,1N0NW@1224|Proteobacteria,2UCVR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7673918_5	1267005.KB911258_gene502	3.531e-166	530.0	COG0683@1|root,COG0683@2|Bacteria,1MWJ1@1224|Proteobacteria,2TT0T@28211|Alphaproteobacteria,3N79P@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	Receptor family ligand binding region	livK	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
HKD2_k127_7673918_21	631454.N177_4189	2.155e-54	205.0	COG0683@1|root,COG0683@2|Bacteria,1MWJ1@1224|Proteobacteria,2TT0T@28211|Alphaproteobacteria,1JPS4@119043|Rhodobiaceae	28211|Alphaproteobacteria	E	Receptor family ligand binding region	livK	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
HKD2_k127_7673918_2	1429916.X566_24070	1.961e-196	620.0	COG0015@1|root,COG0015@2|Bacteria,1MV4B@1224|Proteobacteria,2TQUE@28211|Alphaproteobacteria,3JSWI@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	F	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily	purB	GO:0003674,GO:0003824,GO:0004018,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016829,GO:0016840,GO:0016842,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046033,GO:0046390,GO:0046483,GO:0055086,GO:0070626,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	-	ADSL_C,Lyase_1
HKD2_k127_7673918_25	1089547.KB913013_gene3880	3.07e-36	141.0	COG3422@1|root,COG3422@2|Bacteria,4NS9J@976|Bacteroidetes,47QKZ@768503|Cytophagia	976|Bacteroidetes	T	Domain of unknown function (DUF1508)	-	-	-	ko:K09946	-	-	-	-	ko00000	-	-	-	DUF1508
HKD2_k127_7673918_32	1487953.JMKF01000037_gene3240	1.114e-16	90.0	COG2931@1|root,COG2931@2|Bacteria	2|Bacteria	Q	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_16,He_PIG,HemolysinCabind,P_proprotein,Peptidase_M10_C,Peptidase_S8,W_rich_C
HKD2_k127_7673918_28	58123.JOFJ01000002_gene2456	1.083e-27	129.0	COG2203@1|root,COG4585@1|root,COG2203@2|Bacteria,COG4585@2|Bacteria,2I312@201174|Actinobacteria,4EHRD@85012|Streptosporangiales	201174|Actinobacteria	T	GAF domain	-	-	2.7.13.3	ko:K02480	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	GAF_2,HATPase_c,HisKA_3
HKD2_k127_7673918_24	479434.Sthe_0156	1.206e-36	158.0	COG3850@1|root,COG3850@2|Bacteria,2GBH4@200795|Chloroflexi,27XF0@189775|Thermomicrobia	189775|Thermomicrobia	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA_3
HKD2_k127_7673918_26	1304865.JAGF01000001_gene1900	1.451e-35	143.0	COG2197@1|root,COG2197@2|Bacteria,2GJRY@201174|Actinobacteria	201174|Actinobacteria	T	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HKD2_k127_7673918_22	1123368.AUIS01000006_gene566	8.523e-54	209.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,2NDJD@225057|Acidithiobacillales	225057|Acidithiobacillales	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GAF_2,GGDEF,PAS_4,Response_reg
HKD2_k127_7673918_34	886293.Sinac_1369	4.641e-12	72.0	COG4747@1|root,COG4747@2|Bacteria,2J4QK@203682|Planctomycetes	203682|Planctomycetes	S	ACT domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7673918_14	644966.Tmar_0214	2.37e-99	357.0	COG0421@1|root,COG0421@2|Bacteria,1UI4A@1239|Firmicutes,25GIE@186801|Clostridia	186801|Clostridia	E	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	-	-	-	-	-	-	-	-	-	-	-	-	Spermine_synth
HKD2_k127_7673918_13	290315.Clim_1318	7.26e-107	355.0	COG0265@1|root,COG0265@2|Bacteria	2|Bacteria	O	serine-type endopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	FHA,Trypsin,Trypsin_2
HKD2_k127_7673918_4	639030.JHVA01000001_gene3907	4.701e-192	615.0	COG0433@1|root,COG0433@2|Bacteria,3Y69X@57723|Acidobacteria	57723|Acidobacteria	S	Bacterial protein of unknown function (DUF853)	-	-	-	-	-	-	-	-	-	-	-	-	DUF853
HKD2_k127_7673918_18	1121324.CLIT_5c00330	3.592e-70	254.0	COG0633@1|root,COG3894@1|root,COG0633@2|Bacteria,COG3894@2|Bacteria,1TP0H@1239|Firmicutes,247S0@186801|Clostridia,25R30@186804|Peptostreptococcaceae	186801|Clostridia	C	Domain of unknown function (DUF4445)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4445,Fer2
HKD2_k127_7673918_9	1121866.AUGK01000003_gene1319	8.145e-136	439.0	COG0152@1|root,COG0152@2|Bacteria,2GK3H@201174|Actinobacteria,4CUV7@84998|Coriobacteriia	84998|Coriobacteriia	F	SAICAR synthetase	purC	-	6.3.2.6	ko:K01923	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04591	RC00064,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	SAICAR_synt
HKD2_k127_7673918_31	1196028.ALEF01000061_gene1051	5.387e-22	97.0	COG1828@1|root,COG1828@2|Bacteria,1VEH1@1239|Firmicutes,4HP0E@91061|Bacilli,4C6XE@84406|Virgibacillus	91061|Bacilli	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purS	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	iYO844.BSU06460	PurS
HKD2_k127_7673918_17	697281.Mahau_1635	3.796e-83	287.0	COG0047@1|root,COG0047@2|Bacteria,1TP1B@1239|Firmicutes,24A2E@186801|Clostridia,42EVD@68295|Thermoanaerobacterales	186801|Clostridia	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purQ	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase_5
HKD2_k127_7673918_0	555088.DealDRAFT_1867	2.207e-263	837.0	COG0046@1|root,COG0046@2|Bacteria,1TPAS@1239|Firmicutes,247W2@186801|Clostridia,42KE4@68298|Syntrophomonadaceae	186801|Clostridia	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C,GATase_5
HKD2_k127_7673918_27	1121272.KB903272_gene66	1.673e-34	139.0	28JRZ@1|root,2Z9HI@2|Bacteria,2H9EF@201174|Actinobacteria,4DD50@85008|Micromonosporales	201174|Actinobacteria	S	Domain of unknown function (DUF4126)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4126
HKD2_k127_7673918_6	1504822.CCNO01000008_gene2029	7.626e-166	546.0	COG0034@1|root,COG0034@2|Bacteria,2NNSY@2323|unclassified Bacteria	2|Bacteria	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009507,GO:0009536,GO:0040007,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_6,GATase_7,Pribosyltran
HKD2_k127_7673918_15	264732.Moth_0454	5.26e-98	331.0	COG2170@1|root,COG2170@2|Bacteria,1VUBC@1239|Firmicutes,24XQG@186801|Clostridia,42I2W@68295|Thermoanaerobacterales	186801|Clostridia	S	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7673918_19	264732.Moth_0455	1.528e-65	239.0	COG0688@1|root,COG0688@2|Bacteria,1V3FQ@1239|Firmicutes,24FXF@186801|Clostridia,42H62@68295|Thermoanaerobacterales	186801|Clostridia	I	Phosphatidylserine decarboxylase	psd	-	4.1.1.65	ko:K01613	ko00564,ko01100,ko01110,map00564,map01100,map01110	M00093	R02055	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	PS_Dcarbxylase
HKD2_k127_7673918_16	926569.ANT_03690	6.954e-91	313.0	COG2234@1|root,COG2234@2|Bacteria	2|Bacteria	DZ	aminopeptidase activity	-	-	3.4.11.10,3.4.11.24,3.4.11.6	ko:K19701,ko:K19702	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M28
HKD2_k127_7673918_10	649764.HMPREF0762_00995	7.471e-135	442.0	COG0150@1|root,COG0150@2|Bacteria,2GJNY@201174|Actinobacteria,4CUJR@84998|Coriobacteriia	84998|Coriobacteriia	F	Phosphoribosylformylglycinamidine cyclo-ligase	purM	-	6.3.3.1	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04208	RC01100	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
HKD2_k127_7673918_35	408672.NBCG_05638	3.15e-11	73.0	COG1376@1|root,COG1376@2|Bacteria,2IIU7@201174|Actinobacteria,4DRAD@85009|Propionibacteriales	201174|Actinobacteria	S	L,D-transpeptidase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	YkuD
HKD2_k127_7673918_20	471855.Shel_01770	7.143e-64	236.0	COG0299@1|root,COG0299@2|Bacteria,2H8QB@201174|Actinobacteria,4CUUR@84998|Coriobacteriia	84998|Coriobacteriia	F	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate	purN	-	2.1.2.2	ko:K11175	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	M00048	R04325,R04326	RC00026,RC00197,RC01128	ko00000,ko00001,ko00002,ko01000	-	-	-	Formyl_trans_N
HKD2_k127_7673918_40	1380387.JADM01000008_gene831	1.926e-06	59.0	COG0115@1|root,COG0115@2|Bacteria,1MZAK@1224|Proteobacteria,1RPPG@1236|Gammaproteobacteria,1XK0U@135619|Oceanospirillales	135619|Oceanospirillales	EH	Branched-chain amino acid aminotransferase 4-amino-4-deoxychorismate lyase	pabC	-	4.1.3.38	ko:K02619	ko00790,map00790	-	R05553	RC01843,RC02148	ko00000,ko00001,ko01000	-	-	-	Aminotran_4
HKD2_k127_7673918_3	1118060.CAGZ01000030_gene1106	4.127e-195	623.0	COG0138@1|root,COG0138@2|Bacteria,2GJWU@201174|Actinobacteria,4CV0C@84998|Coriobacteriia	84998|Coriobacteriia	F	Bifunctional purine biosynthesis protein PurH	purH	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AICARFT_IMPCHas,MGS
HKD2_k127_7673918_39	87626.PTD2_04958	6.677e-07	52.0	2DTNT@1|root,33M3P@2|Bacteria,1NH3S@1224|Proteobacteria,1SGZB@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7673918_33	305700.B447_12022	1.463e-14	88.0	2ETVI@1|root,33MCS@2|Bacteria,1PUAN@1224|Proteobacteria,2W09P@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7673918_29	1463934.JOCF01000081_gene5659	5.629e-27	126.0	COG0791@1|root,COG3409@1|root,COG0791@2|Bacteria,COG3409@2|Bacteria,2I61A@201174|Actinobacteria	201174|Actinobacteria	M	Peptidoglycan-binding domain 1 protein	-	-	-	-	-	-	-	-	-	-	-	-	NLPC_P60,PG_binding_1
HKD2_k127_7673918_23	1121106.JQKB01000012_gene4682	1.27e-38	162.0	COG0265@1|root,COG0823@1|root,COG2931@1|root,COG0265@2|Bacteria,COG0823@2|Bacteria,COG2931@2|Bacteria	2|Bacteria	Q	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	ko:K08372	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	HemolysinCabind,NACHT,PDZ_2,Trypsin_2,VCBS
HKD2_k127_7673918_38	645465.ACUR01000256_gene2106	1.87e-09	66.0	COG0705@1|root,COG0705@2|Bacteria,2GJYG@201174|Actinobacteria	201174|Actinobacteria	NU	Rhomboid family	gluP	-	3.4.21.105	ko:K19225	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Rhomboid,zf-B_box
HKD2_k127_7673918_1	1123242.JH636435_gene1911	4.489e-249	787.0	COG0210@1|root,COG0210@2|Bacteria,2IY8S@203682|Planctomycetes	203682|Planctomycetes	L	UvrD-like helicase C-terminal domain	-	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
HKD2_k127_7673918_36	1380386.JIAW01000003_gene621	6.933e-11	63.0	COG5207@1|root,COG5207@2|Bacteria,2IKW9@201174|Actinobacteria,23AEN@1762|Mycobacteriaceae	201174|Actinobacteria	O	Zn-finger in ubiquitin-hydrolases and other protein	-	-	-	-	-	-	-	-	-	-	-	-	zf-UBP
HKD2_k127_7675724_8	1157638.KB892207_gene6792	8.504e-21	94.0	COG4585@1|root,COG4585@2|Bacteria,2GKV2@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
HKD2_k127_7675724_2	1068978.AMETH_0125	1.343e-86	295.0	COG2197@1|root,COG2197@2|Bacteria,2GJ46@201174|Actinobacteria,4E2DS@85010|Pseudonocardiales	201174|Actinobacteria	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HKD2_k127_7675724_9	573370.DMR_16330	1.566e-11	77.0	COG0845@1|root,COG0845@2|Bacteria,1MUMV@1224|Proteobacteria,42PK1@68525|delta/epsilon subdivisions,2WJ65@28221|Deltaproteobacteria,2M83T@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_D23
HKD2_k127_7675724_1	502558.EGYY_21940	6.594e-95	318.0	COG1136@1|root,COG1136@2|Bacteria,2GK3I@201174|Actinobacteria,4CV1R@84998|Coriobacteriia	84998|Coriobacteriia	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD2_k127_7675724_0	871968.DESME_13845	8.646e-96	327.0	COG0577@1|root,COG0577@2|Bacteria,1TPUU@1239|Firmicutes,2483J@186801|Clostridia,260DV@186807|Peptococcaceae	186801|Clostridia	V	ABC-type antimicrobial peptide transport system, permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HKD2_k127_7675724_3	1031288.AXAA01000001_gene2241	2.266e-63	224.0	COG2738@1|root,COG2738@2|Bacteria,1TPD3@1239|Firmicutes,2490Y@186801|Clostridia,36FA7@31979|Clostridiaceae	186801|Clostridia	S	zinc metallopeptidase	yugP	-	-	ko:K06973	-	-	-	-	ko00000	-	-	-	Zn_peptidase_2
HKD2_k127_7675724_5	404380.Gbem_0849	3.986e-45	179.0	COG0859@1|root,COG0859@2|Bacteria,1MXA2@1224|Proteobacteria,42NEW@68525|delta/epsilon subdivisions,2WJNJ@28221|Deltaproteobacteria,43S6D@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Glycosyltransferase family 9 (heptosyltransferase)	-	-	-	ko:K02843	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9
HKD2_k127_7675724_4	1292034.OR37_01302	2.813e-60	221.0	COG0615@1|root,COG2870@1|root,COG0615@2|Bacteria,COG2870@2|Bacteria,1MV3Z@1224|Proteobacteria,2TU12@28211|Alphaproteobacteria,2KFUY@204458|Caulobacterales	204458|Caulobacterales	H	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose	hldE	-	2.7.1.167,2.7.7.70	ko:K03272	ko00540,ko01100,map00540,map01100	M00064	R05644,R05646	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CTP_transf_like,PfkB
HKD2_k127_7675724_6	882086.SacxiDRAFT_0835	1.938e-44	167.0	COG0615@1|root,COG2870@1|root,COG0615@2|Bacteria,COG2870@2|Bacteria,2GKU1@201174|Actinobacteria,4DYQE@85010|Pseudonocardiales	201174|Actinobacteria	H	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose	hldE	-	2.7.1.167,2.7.7.70	ko:K03272	ko00540,ko01100,map00540,map01100	M00064	R05644,R05646	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CTP_transf_like,PfkB
HKD2_k127_7675724_10	1211814.CAPG01000092_gene4229	1.693e-06	57.0	29S0J@1|root,30D4W@2|Bacteria,1UAUR@1239|Firmicutes,4IM7J@91061|Bacilli,1ZJEQ@1386|Bacillus	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7675724_7	479431.Namu_1998	2.806e-23	108.0	2F7XJ@1|root,340BF@2|Bacteria,2H669@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7699236_7	1121422.AUMW01000013_gene1417	8.28e-73	250.0	COG1775@1|root,COG1775@2|Bacteria,1TPEF@1239|Firmicutes,24A11@186801|Clostridia,2609U@186807|Peptococcaceae	186801|Clostridia	E	Benzoyl-CoA reductase 2-hydroxyglutaryl-CoA dehydratase subunit BcrC BadD HgdB	-	-	-	-	-	-	-	-	-	-	-	-	HGD-D
HKD2_k127_7699236_9	1034345.CAEM01000023_gene815	3.709e-70	265.0	COG0077@1|root,COG0077@2|Bacteria,2GJQ5@201174|Actinobacteria,4CUEH@84998|Coriobacteriia	84998|Coriobacteriia	E	Prephenate dehydratase	-	-	4.2.1.51,5.4.99.5	ko:K04518,ko:K14170	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024,M00025	R00691,R01373,R01715	RC00360,RC03116	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,CM_2,PDT
HKD2_k127_7699236_10	1379698.RBG1_1C00001G0325	1.072e-48	194.0	COG2199@1|root,COG3706@2|Bacteria,2NPJ3@2323|unclassified Bacteria	2|Bacteria	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,GAF_3,GGDEF,MASE3,PAS_3,PAS_4,Response_reg
HKD2_k127_7699236_16	867903.ThesuDRAFT_00479	3.418e-15	83.0	COG1196@1|root,COG1196@2|Bacteria,1VAV4@1239|Firmicutes,24NPU@186801|Clostridia,3WDNY@538999|Clostridiales incertae sedis	186801|Clostridia	D	Protein of unknown function (DUF4446)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4446
HKD2_k127_7699236_4	1195236.CTER_4689	8.427e-81	279.0	COG1691@1|root,COG1691@2|Bacteria,1TP0Z@1239|Firmicutes,24815@186801|Clostridia,3WIER@541000|Ruminococcaceae	186801|Clostridia	S	AIR carboxylase	-	-	-	ko:K06898	-	-	-	-	ko00000	-	-	-	AIRC
HKD2_k127_7699236_5	404380.Gbem_3626	1.328e-77	274.0	COG1641@1|root,COG1641@2|Bacteria,1MUKU@1224|Proteobacteria,42MHQ@68525|delta/epsilon subdivisions,2WJAC@28221|Deltaproteobacteria,43U9E@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Belongs to the LarC family	-	-	4.99.1.12	ko:K09121	-	-	-	-	ko00000,ko01000	-	-	-	DUF111
HKD2_k127_7699236_6	243231.GSU1613	2.753e-76	264.0	COG1194@1|root,COG1194@2|Bacteria,1MUD4@1224|Proteobacteria,42PDR@68525|delta/epsilon subdivisions,2WJ60@28221|Deltaproteobacteria,43TKZ@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	endonuclease III	mutY	-	-	ko:K03575	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD,NUDIX_4
HKD2_k127_7699236_1	292459.STH2398	7.732e-116	402.0	COG0745@1|root,COG2202@1|root,COG5002@1|root,COG0745@2|Bacteria,COG2202@2|Bacteria,COG5002@2|Bacteria,1VRP7@1239|Firmicutes,24YHW@186801|Clostridia	186801|Clostridia	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,Hpt,PAS_9,Response_reg
HKD2_k127_7699236_14	871968.DESME_03665	2.385e-31	128.0	COG0745@1|root,COG0745@2|Bacteria,1VSVV@1239|Firmicutes,24K2V@186801|Clostridia,263FZ@186807|Peptococcaceae	186801|Clostridia	K	PFAM Response regulator receiver domain	-	-	-	ko:K07658	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
HKD2_k127_7699236_15	767817.Desgi_3626	5.076e-28	119.0	COG0745@1|root,COG0745@2|Bacteria,1TPWS@1239|Firmicutes,25AZ2@186801|Clostridia,2605V@186807|Peptococcaceae	186801|Clostridia	K	PFAM response regulator receiver	phoB	-	-	ko:K02483,ko:K07658,ko:K07668	ko02020,map02020	M00434,M00459	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
HKD2_k127_7699236_11	374847.Kcr_0887	4.352e-38	159.0	COG0109@1|root,arCOG00479@2157|Archaea	2157|Archaea	O	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group	ctaB	GO:0003674,GO:0003824,GO:0004311,GO:0004659,GO:0006091,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0015980,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0045333,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.141	ko:K02257	ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714	M00154	R07411	RC01786	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029	-	-	-	COX15-CtaA,UbiA
HKD2_k127_7699236_18	1280663.ATVR01000040_gene2522	0.0007	43.0	29VSW@1|root,30HAH@2|Bacteria,1UHD2@1239|Firmicutes,25Q3M@186801|Clostridia,4C1J9@830|Butyrivibrio	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7699236_13	667014.Thein_2021	1.297e-34	140.0	COG1881@1|root,COG1881@2|Bacteria	2|Bacteria	S	positive regulation of acetylcholine metabolic process	-	-	-	ko:K06910	-	-	-	-	ko00000	-	-	-	PBP
HKD2_k127_7699236_8	502558.EGYY_28280	2.54e-71	264.0	COG0515@1|root,COG0515@2|Bacteria,2GJ1J@201174|Actinobacteria,4CUH6@84998|Coriobacteriia	84998|Coriobacteriia	KLT	Kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HKD2_k127_7699236_12	266117.Rxyl_0026	3.098e-35	144.0	COG1716@1|root,COG1716@2|Bacteria,2GNU2@201174|Actinobacteria,4CQB6@84995|Rubrobacteria	84995|Rubrobacteria	T	Protein of unknown function (DUF2662)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3662,FHA
HKD2_k127_7699236_17	1032480.MLP_52820	3.534e-15	80.0	COG1716@1|root,COG1716@2|Bacteria,2GKA7@201174|Actinobacteria,4DQIX@85009|Propionibacteriales	201174|Actinobacteria	T	Inner membrane component of T3SS, cytoplasmic domain	fhaB	GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006950,GO:0006979,GO:0008150,GO:0009987,GO:0016020,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044464,GO:0050896,GO:0051301,GO:0051704,GO:0071944	-	-	-	-	-	-	-	-	-	-	FHA,Yop-YscD_cpl
HKD2_k127_7699236_2	479437.Elen_3041	5.699e-90	309.0	COG0631@1|root,COG0631@2|Bacteria,2GJ3M@201174|Actinobacteria,4CUGE@84998|Coriobacteriia	84998|Coriobacteriia	T	phosphatase 2C	-	-	3.1.3.16	ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	BofC_C,PP2C,PP2C_2
HKD2_k127_7699236_0	502558.EGYY_28730	5.644e-248	795.0	COG0768@1|root,COG0772@1|root,COG0768@2|Bacteria,COG0772@2|Bacteria,2GJTI@201174|Actinobacteria,4CUFK@84998|Coriobacteriia	84998|Coriobacteriia	DM	Belongs to the SEDS family	-	-	-	-	-	-	-	-	-	-	-	-	FTSW_RODA_SPOVE,Transpeptidase
HKD2_k127_7699236_3	479437.Elen_3043	1.475e-88	298.0	COG0515@1|root,COG2815@1|root,COG0515@2|Bacteria,COG2815@2|Bacteria,2GJ1J@201174|Actinobacteria,4CUKV@84998|Coriobacteriia	84998|Coriobacteriia	KLT	Kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
HKD2_k127_7724144_0	1122947.FR7_4495	5.086e-55	198.0	COG1480@1|root,COG1480@2|Bacteria,1TR1A@1239|Firmicutes,4H2Q1@909932|Negativicutes	909932|Negativicutes	S	metal-dependent phosphohydrolase, 7TM intracellular region	-	-	-	ko:K07037	-	-	-	-	ko00000	-	-	-	7TM-7TMR_HD,7TMR-HDED,HD
HKD2_k127_7724144_3	502558.EGYY_14310	2.201e-31	128.0	COG0319@1|root,COG0319@2|Bacteria,2GMUF@201174|Actinobacteria,4CVZI@84998|Coriobacteriia	84998|Coriobacteriia	S	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA	ybeY	-	-	ko:K07042	-	-	-	-	ko00000,ko03009	-	-	-	UPF0054
HKD2_k127_7724144_1	941824.TCEL_01977	2.01e-51	190.0	COG0671@1|root,COG0818@1|root,COG0671@2|Bacteria,COG0818@2|Bacteria,1VEGR@1239|Firmicutes,248FD@186801|Clostridia,36DSP@31979|Clostridiaceae	186801|Clostridia	IM	Diacylglycerol kinase	dgkA	-	2.7.1.107,2.7.1.66	ko:K00887,ko:K00901	ko00550,ko00561,ko00564,ko01100,ko01110,ko04070,ko04072,ko05231,map00550,map00561,map00564,map01100,map01110,map04070,map04072,map05231	-	R02240,R05626	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	DAGK_prokar,PAP2
HKD2_k127_7724144_2	1121877.JQKF01000022_gene2275	8.553e-38	149.0	COG1253@1|root,COG1253@2|Bacteria,2GIWR@201174|Actinobacteria,4CP58@84992|Acidimicrobiia	84992|Acidimicrobiia	S	Transporter associated domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
HKD2_k127_7800383_1	1349820.M707_09040	8.566e-86	292.0	COG1131@1|root,COG1131@2|Bacteria,2GKWB@201174|Actinobacteria	201174|Actinobacteria	V	abc transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,PLDc_N
HKD2_k127_7800383_2	1125863.JAFN01000001_gene836	8.301e-71	257.0	COG0438@1|root,COG0438@2|Bacteria,1NA28@1224|Proteobacteria,42NZA@68525|delta/epsilon subdivisions,2WK1T@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	DUF3524,Glycos_transf_1
HKD2_k127_7800383_0	479437.Elen_1658	9.202e-110	373.0	COG0301@1|root,COG0301@2|Bacteria,2GMFY@201174|Actinobacteria,4CU8T@84998|Coriobacteriia	84998|Coriobacteriia	H	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS	thiI	-	2.8.1.4	ko:K03151	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07461	-	ko00000,ko00001,ko01000,ko03016	-	-	-	THUMP,ThiI
HKD2_k127_7800383_3	1348338.ADILRU_1535	2.376e-10	66.0	COG1758@1|root,COG1758@2|Bacteria,2IQHU@201174|Actinobacteria,4FPHE@85023|Microbacteriaceae	201174|Actinobacteria	K	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits	rpoZ	GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030312,GO:0040007,GO:0044464,GO:0071944	2.7.7.6	ko:K03060	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb6
HKD2_k127_7800383_5	883066.HMPREF9233_01598	0.0002316	45.0	COG0194@1|root,COG0194@2|Bacteria,2GK2M@201174|Actinobacteria,4D36U@85005|Actinomycetales	201174|Actinobacteria	F	Essential for recycling GMP and indirectly, cGMP	gmk	GO:0003674,GO:0003824,GO:0004385,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009150,GO:0009161,GO:0009165,GO:0009167,GO:0009179,GO:0009185,GO:0009259,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0042278,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046483,GO:0046710,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901657	2.7.4.8	ko:K00942	ko00230,ko01100,map00230,map01100	M00050	R00332,R02090	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_kin
HKD2_k127_7869565_1	1121430.JMLG01000034_gene133	1.998e-113	372.0	COG1775@1|root,COG1775@2|Bacteria,1TPEF@1239|Firmicutes,24A11@186801|Clostridia,2609U@186807|Peptococcaceae	186801|Clostridia	E	Benzoyl-CoA reductase 2-hydroxyglutaryl-CoA dehydratase subunit BcrC BadD HgdB	-	-	-	-	-	-	-	-	-	-	-	-	HGD-D
HKD2_k127_7869565_3	1121396.KB893051_gene3447	2.908e-75	259.0	COG1924@1|root,COG1924@2|Bacteria,1R6HU@1224|Proteobacteria,42PM0@68525|delta/epsilon subdivisions,2WJRP@28221|Deltaproteobacteria,2MHRM@213118|Desulfobacterales	28221|Deltaproteobacteria	I	PFAM BadF BadG BcrA BcrD ATPase family	-	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG
HKD2_k127_7869565_7	498761.HM1_0963	2.577e-26	111.0	COG0425@1|root,COG0425@2|Bacteria,1V6BY@1239|Firmicutes,24JW8@186801|Clostridia	186801|Clostridia	O	Belongs to the sulfur carrier protein TusA family	yedF	-	-	ko:K04085	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	DrsE,TusA
HKD2_k127_7869565_6	1195236.CTER_2595	1.043e-28	128.0	COG2768@1|root,COG2768@2|Bacteria,1UK08@1239|Firmicutes,25FG6@186801|Clostridia,3WK7Y@541000|Ruminococcaceae	186801|Clostridia	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
HKD2_k127_7869565_2	1125863.JAFN01000001_gene1968	4.771e-97	328.0	COG1456@1|root,COG1456@2|Bacteria,1R6BH@1224|Proteobacteria,42NKF@68525|delta/epsilon subdivisions,2WJ72@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM CO dehydrogenase acetyl-CoA synthase delta subunit, TIM barrel	-	-	2.1.1.245	ko:K00197	ko00680,ko00720,ko01120,ko01200,map00680,map00720,map01120,map01200	M00357,M00377,M00422	R09096,R10219,R10243	RC00004,RC00113,RC02977	ko00000,ko00001,ko00002,ko01000	-	-	-	CdhD
HKD2_k127_7869565_4	243365.CV_1360	3.962e-49	179.0	COG1970@1|root,COG1970@2|Bacteria,1RHG8@1224|Proteobacteria,2VT9K@28216|Betaproteobacteria,2KRC6@206351|Neisseriales	206351|Neisseriales	M	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell	mscL	-	-	ko:K03282	-	-	-	-	ko00000,ko02000	1.A.22.1	-	-	MscL
HKD2_k127_7869565_5	1217718.ALOU01000097_gene4914	4.305e-42	161.0	COG2110@1|root,COG2110@2|Bacteria,1RCWP@1224|Proteobacteria,2VRGS@28216|Betaproteobacteria,1K3Q8@119060|Burkholderiaceae	28216|Betaproteobacteria	S	PFAM Appr-1-p processing domain protein	ymdB	-	-	-	-	-	-	-	-	-	-	-	Macro
HKD2_k127_7869565_0	502558.EGYY_28210	1.675e-183	585.0	COG0172@1|root,COG0172@2|Bacteria,2GIWP@201174|Actinobacteria,4CUID@84998|Coriobacteriia	84998|Coriobacteriia	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Seryl_tRNA_N,tRNA-synt_2b
HKD2_k127_7893575_0	1384484.AEQU_1006	8.839e-215	682.0	COG0060@1|root,COG0060@2|Bacteria,2GK9M@201174|Actinobacteria,4CUMK@84998|Coriobacteriia	84998|Coriobacteriia	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1,zf-FPG_IleRS
HKD2_k127_7957091_24	926569.ANT_20810	7.522e-07	57.0	COG4818@1|root,COG4818@2|Bacteria,2G9PA@200795|Chloroflexi	200795|Chloroflexi	S	Domain of unknown function (DUF4870)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4870
HKD2_k127_7957091_11	1121472.AQWN01000005_gene2345	2.06e-50	193.0	COG4942@1|root,COG4942@2|Bacteria,1TQ5I@1239|Firmicutes,248ZG@186801|Clostridia,25ZZ8@186807|Peptococcaceae	186801|Clostridia	D	PFAM peptidase	-	-	-	ko:K21471	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_M23
HKD2_k127_7957091_8	649764.HMPREF0762_01962	5.194e-59	210.0	COG0193@1|root,COG0193@2|Bacteria,2GKCV@201174|Actinobacteria,4CV7A@84998|Coriobacteriia	84998|Coriobacteriia	J	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis	pth	-	3.1.1.29	ko:K01056	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	Pept_tRNA_hydro
HKD2_k127_7957091_15	1328313.DS2_08510	3.511e-36	145.0	COG1825@1|root,COG1825@2|Bacteria,1RDH0@1224|Proteobacteria,1S46A@1236|Gammaproteobacteria,466F7@72275|Alteromonadaceae	1236|Gammaproteobacteria	J	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance	ctc	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02897	ko03010,map03010	M00178	-	-	ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L25p,Ribosomal_TL5_C
HKD2_k127_7957091_3	370438.PTH_0105	3.791e-107	357.0	COG0462@1|root,COG0462@2|Bacteria,1TQ6Q@1239|Firmicutes,248ZN@186801|Clostridia,2605Q@186807|Peptococcaceae	186801|Clostridia	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	prs	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyl_synth,Pribosyltran_N
HKD2_k127_7957091_1	479437.Elen_2772	2.032e-147	482.0	COG1207@1|root,COG1207@2|Bacteria,2GJS1@201174|Actinobacteria,4CUFP@84998|Coriobacteriia	84998|Coriobacteriia	M	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain	glmU	-	2.3.1.157,2.7.7.23	ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,Hexapep_2,NTP_transf_3,NTP_transferase
HKD2_k127_7957091_18	1121090.KB894705_gene1063	8.768e-24	104.0	COG2088@1|root,COG2088@2|Bacteria,1V9ZG@1239|Firmicutes,4HIPT@91061|Bacilli,1ZGXK@1386|Bacillus	91061|Bacilli	D	Essential for sporulation. Interferes with or is a negative regulator of the pathway leading to asymmetric septation	spoVG	GO:0000003,GO:0008150,GO:0019954,GO:0030436,GO:0032502,GO:0043934	-	ko:K06412	-	-	-	-	ko00000	-	-	-	SpoVG
HKD2_k127_7957091_12	370438.PTH_0098	1.776e-46	181.0	COG0746@1|root,COG0746@2|Bacteria,1V4AK@1239|Firmicutes,249SR@186801|Clostridia,267CR@186807|Peptococcaceae	186801|Clostridia	H	MobA-like NTP transferase domain	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_3
HKD2_k127_7957091_16	1384484.AEQU_2018	4.731e-35	149.0	COG1947@1|root,COG1947@2|Bacteria,2GKXD@201174|Actinobacteria,4CVNV@84998|Coriobacteriia	84998|Coriobacteriia	F	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol	ispE	-	2.7.1.148	ko:K00919	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05634	RC00002,RC01439	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
HKD2_k127_7957091_19	1111121.HMPREF1247_0707	3.578e-23	101.0	COG4466@1|root,COG4466@2|Bacteria,2HV30@201174|Actinobacteria,4CW7T@84998|Coriobacteriia	84998|Coriobacteriia	S	Biofilm formation stimulator VEG	-	-	-	-	-	-	-	-	-	-	-	-	VEG
HKD2_k127_7957091_5	649764.HMPREF0762_00786	4.166e-70	254.0	COG0030@1|root,COG0030@2|Bacteria,2GKBT@201174|Actinobacteria,4CUIM@84998|Coriobacteriia	84998|Coriobacteriia	J	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	-	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
HKD2_k127_7957091_14	429009.Adeg_2112	5.124e-39	160.0	COG3583@1|root,COG3584@1|root,COG3583@2|Bacteria,COG3584@2|Bacteria,1TTIK@1239|Firmicutes,24997@186801|Clostridia,42ETJ@68295|Thermoanaerobacterales	186801|Clostridia	S	G5 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	3D,DUF348,G5
HKD2_k127_7957091_17	1121472.AQWN01000005_gene2429	1.966e-30	133.0	COG0655@1|root,COG0655@2|Bacteria,1V26K@1239|Firmicutes,24IAS@186801|Clostridia,262W5@186807|Peptococcaceae	186801|Clostridia	S	PFAM NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
HKD2_k127_7957091_4	1384484.AEQU_0537	6.478e-71	249.0	COG0084@1|root,COG0084@2|Bacteria,2GMJJ@201174|Actinobacteria,4CVB7@84998|Coriobacteriia	84998|Coriobacteriia	L	Hydrolase, TatD family	-	-	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
HKD2_k127_7957091_0	1120746.CCNL01000009_gene962	2.877e-175	563.0	COG0143@1|root,COG0143@2|Bacteria,2NNTX@2323|unclassified Bacteria	2|Bacteria	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	GO:0003674,GO:0003824,GO:0004812,GO:0004825,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006431,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g,tRNA_bind
HKD2_k127_7957091_20	1120998.AUFC01000033_gene2303	5.958e-17	85.0	COG2002@1|root,COG2002@2|Bacteria,1VA3H@1239|Firmicutes,24MN7@186801|Clostridia,3WDDB@538999|Clostridiales incertae sedis	186801|Clostridia	K	TIGRFAM looped-hinge helix DNA binding domain, AbrB family	abrB	-	-	ko:K06284	-	-	-	-	ko00000,ko03000	-	-	-	MazE_antitoxin
HKD2_k127_7957091_6	1034345.CAEM01000012_gene731	1.717e-66	242.0	COG0313@1|root,COG0313@2|Bacteria,2GJ9Q@201174|Actinobacteria,4CV23@84998|Coriobacteriia	84998|Coriobacteriia	H	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA	rsmI	-	2.1.1.198	ko:K07056	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TP_methylase
HKD2_k127_7957091_25	926569.ANT_25500	3.543e-06	59.0	2DFV5@1|root,2ZT9W@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7957091_2	370438.PTH_2121	1.411e-121	409.0	COG2768@1|root,COG2768@2|Bacteria,1TQAW@1239|Firmicutes,247IS@186801|Clostridia,260GA@186807|Peptococcaceae	186801|Clostridia	C	Domain of unknown function (DUF362)	-	-	-	ko:K07138	-	-	-	-	ko00000	-	-	-	DUF362,Fer4,Fer4_6
HKD2_k127_7957091_10	1122939.ATUD01000009_gene2999	1.179e-53	202.0	COG1940@1|root,COG1940@2|Bacteria,2GJCQ@201174|Actinobacteria,4CPVZ@84995|Rubrobacteria	84995|Rubrobacteria	GK	ROK family	-	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
HKD2_k127_7957091_23	419947.MRA_2033	5.349e-07	58.0	COG1396@1|root,COG2856@1|root,COG1396@2|Bacteria,COG2856@2|Bacteria,2GRH0@201174|Actinobacteria,235SA@1762|Mycobacteriaceae	201174|Actinobacteria	E	IrrE N-terminal-like domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3,HTH_31,Peptidase_M78
HKD2_k127_7957091_9	443143.GM18_3375	6.452e-59	224.0	COG2206@1|root,COG2206@2|Bacteria,1MW7F@1224|Proteobacteria,42PHB@68525|delta/epsilon subdivisions,2WMJX@28221|Deltaproteobacteria,43S0A@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	PFAM metal-dependent phosphohydrolase HD sub domain	-	-	-	-	-	-	-	-	-	-	-	-	HD,HD_5,KOW
HKD2_k127_7957091_13	1121430.JMLG01000036_gene159	1.067e-44	181.0	COG0642@1|root,COG2205@2|Bacteria,1V10X@1239|Firmicutes,24P7E@186801|Clostridia,260UH@186807|Peptococcaceae	186801|Clostridia	T	Histidine kinase	-	-	2.7.13.3	ko:K10681	ko02020,map02020	M00468	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
HKD2_k127_7957091_7	68219.JNXI01000040_gene5488	2.011e-66	234.0	COG0745@1|root,COG0745@2|Bacteria,2GJE6@201174|Actinobacteria	201174|Actinobacteria	T	Response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
HKD2_k127_7957091_22	694427.Palpr_2699	8.175e-14	76.0	COG2345@1|root,COG2345@2|Bacteria,4NYUQ@976|Bacteroidetes,2FVNT@200643|Bacteroidia	976|Bacteroidetes	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7966807_0	1200792.AKYF01000020_gene5029	3.738e-54	192.0	COG0054@1|root,COG0054@2|Bacteria,1V1DA@1239|Firmicutes,4HFRA@91061|Bacilli,26RCN@186822|Paenibacillaceae	91061|Bacilli	H	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin	ribH	GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.78	ko:K00794	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R04457	RC00960	ko00000,ko00001,ko00002,ko01000	-	-	iSB619.SA_RS08940	DMRL_synthase
HKD2_k127_7966807_1	264732.Moth_1653	3.116e-27	115.0	COG1959@1|root,COG1959@2|Bacteria,1V3QB@1239|Firmicutes,24JIV@186801|Clostridia,42GCN@68295|Thermoanaerobacterales	186801|Clostridia	K	TIGRFAM transcriptional regulator, Rrf2 family	cymR	-	-	-	-	-	-	-	-	-	-	-	Rrf2
HKD2_k127_7997242_22	1150474.JQJI01000007_gene186	2.539e-18	97.0	COG1875@1|root,COG1875@2|Bacteria,2GCGW@200918|Thermotogae	200918|Thermotogae	T	SMART Nucleotide binding protein, PINc	-	-	-	ko:K07175	-	-	-	-	ko00000	-	-	-	PIN_4,PhoH
HKD2_k127_7997242_26	498761.HM1_0985	0.0006358	51.0	COG3063@1|root,COG3063@2|Bacteria,1UKRE@1239|Firmicutes,25G1S@186801|Clostridia	186801|Clostridia	NU	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7997242_8	338963.Pcar_0114	2.366e-83	290.0	COG0492@1|root,COG0492@2|Bacteria,1MV15@1224|Proteobacteria,42MHR@68525|delta/epsilon subdivisions,2WIY8@28221|Deltaproteobacteria,43S0G@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
HKD2_k127_7997242_15	110319.CF8_3784	1.316e-37	144.0	COG3118@1|root,COG3118@2|Bacteria,2IQ9T@201174|Actinobacteria,4DRDT@85009|Propionibacteriales	201174|Actinobacteria	O	Belongs to the thioredoxin family	trxA	GO:0003674,GO:0003824,GO:0004791,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0016671,GO:0019725,GO:0033554,GO:0034599,GO:0042221,GO:0042592,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0047134,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
HKD2_k127_7997242_25	1034345.CAEM01000001_gene445	5.518e-05	49.0	29J48@1|root,31TQM@2|Bacteria,2HV3S@201174|Actinobacteria,4CW92@84998|Coriobacteriia	84998|Coriobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7997242_14	443144.GM21_3628	4.574e-51	184.0	COG0864@1|root,COG0864@2|Bacteria,1RK4R@1224|Proteobacteria,42SID@68525|delta/epsilon subdivisions,2WQ86@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	transcriptional regulator	nikR	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141	-	ko:K07722	-	-	-	-	ko00000,ko03000	-	-	-	NikR_C,RHH_1
HKD2_k127_7997242_11	357808.RoseRS_0174	1.02e-52	198.0	COG0310@1|root,COG0310@2|Bacteria,2G6ZN@200795|Chloroflexi,376DK@32061|Chloroflexia	32061|Chloroflexia	P	PFAM cobalamin (vitamin B12) biosynthesis CbiM protein	-	-	-	ko:K02007	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	CbiM,PDGLE
HKD2_k127_7997242_18	67373.JOBF01000030_gene1791	5.822e-27	127.0	COG0619@1|root,COG0619@2|Bacteria,2GKQ7@201174|Actinobacteria	201174|Actinobacteria	P	Cobalt ABC transporter	cbiQ	-	-	ko:K02008	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	CbiQ
HKD2_k127_7997242_7	1150599.MPHLEI_24019	2.12e-83	283.0	COG1122@1|root,COG1122@2|Bacteria,2GJ0M@201174|Actinobacteria,233WF@1762|Mycobacteriaceae	201174|Actinobacteria	P	ABC transporter	cbiO	-	-	ko:K02006,ko:K02008	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	ABC_tran
HKD2_k127_7997242_0	552811.Dehly_1410	1.384e-221	717.0	COG0068@1|root,COG0068@2|Bacteria,2G5QN@200795|Chloroflexi,34CJB@301297|Dehalococcoidia	301297|Dehalococcoidia	O	Telomere recombination	hypF	-	-	ko:K04656	-	-	-	-	ko00000	-	-	-	Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF
HKD2_k127_7997242_21	1235794.C811_02071	1.272e-19	92.0	COG0298@1|root,COG0298@2|Bacteria,2HVAI@201174|Actinobacteria,4CWJR@84998|Coriobacteriia	84998|Coriobacteriia	O	hydrogenase assembly chaperone HypC HupF	-	-	-	ko:K04653	-	-	-	-	ko00000	-	-	-	HupF_HypC
HKD2_k127_7997242_1	1232436.CAPF01000077_gene1086	1.843e-145	470.0	COG0409@1|root,COG0409@2|Bacteria,2GMHA@201174|Actinobacteria,4CUKQ@84998|Coriobacteriia	84998|Coriobacteriia	O	hydrogenase expression formation protein HypD	hypD	-	-	ko:K04654	-	-	-	-	ko00000	-	-	-	HypD
HKD2_k127_7997242_2	742818.HMPREF9451_01706	3.128e-138	449.0	COG0309@1|root,COG0309@2|Bacteria,2GJ7N@201174|Actinobacteria,4CUNH@84998|Coriobacteriia	84998|Coriobacteriia	O	hydrogenase expression formation protein HypE	hypE	-	-	ko:K04655	-	-	-	-	ko00000	-	-	-	AIRS,AIRS_C
HKD2_k127_7997242_20	1499680.CCFE01000030_gene3672	3.939e-21	104.0	COG0697@1|root,COG0697@2|Bacteria,1UAMA@1239|Firmicutes,4HBUB@91061|Bacilli,1ZQ38@1386|Bacillus	91061|Bacilli	EG	COG0697 Permeases of the drug metabolite transporter (DMT) superfamily	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HKD2_k127_7997242_4	1382356.JQMP01000003_gene1989	4.52e-108	370.0	COG0166@1|root,COG0176@1|root,COG0166@2|Bacteria,COG0176@2|Bacteria,2G67J@200795|Chloroflexi,27XXA@189775|Thermomicrobia	189775|Thermomicrobia	G	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway	tal	-	2.2.1.2,5.3.1.9	ko:K13810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00004,M00007,M00114	R01827,R02739,R02740,R03321	RC00376,RC00439,RC00563,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	PGI,TAL_FSA
HKD2_k127_7997242_17	883126.HMPREF9710_02789	6.426e-30	126.0	COG0622@1|root,COG0622@2|Bacteria,1RGUN@1224|Proteobacteria,2VT3X@28216|Betaproteobacteria,477KF@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Calcineurin-like phosphoesterase superfamily domain	-	-	-	ko:K07095	-	-	-	-	ko00000	-	-	-	Metallophos_2
HKD2_k127_7997242_9	469378.Ccur_01160	3.822e-79	271.0	COG3279@1|root,COG3279@2|Bacteria,2IPFZ@201174|Actinobacteria,4CYIJ@84998|Coriobacteriia	84998|Coriobacteriia	K	response regulator receiver	-	-	-	ko:K07705	ko02020,map02020	M00492	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	LytTR,Response_reg
HKD2_k127_7997242_3	742818.HMPREF9451_01697	7.763e-111	374.0	COG3275@1|root,COG3275@2|Bacteria,2GJD4@201174|Actinobacteria,4CUX5@84998|Coriobacteriia	84998|Coriobacteriia	T	histidine kinase DNA gyrase B	-	-	2.7.13.3	ko:K07704	ko02020,map02020	M00492	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	GAF_3,HATPase_c,His_kinase
HKD2_k127_7997242_24	500153.JOEK01000003_gene839	1.397e-05	57.0	COG0454@1|root,COG0456@2|Bacteria,2IHRD@201174|Actinobacteria	201174|Actinobacteria	K	Acetyltransferase (GNAT) family	ypeA	-	2.3.1.1	ko:K22477	ko00220,ko01210,ko01230,map00220,map01210,map01230	M00028	R00259	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetyltransf_1
HKD2_k127_7997242_19	710685.MycrhN_4146	1.784e-23	109.0	COG0730@1|root,COG0730@2|Bacteria,2I5VT@201174|Actinobacteria,234VT@1762|Mycobacteriaceae	201174|Actinobacteria	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
HKD2_k127_7997242_5	1034345.CAEM01000004_gene1467	4.918e-105	354.0	COG1216@1|root,COG1216@2|Bacteria,2HUI9@201174|Actinobacteria,4CUTI@84998|Coriobacteriia	84998|Coriobacteriia	S	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3
HKD2_k127_7997242_6	552811.Dehly_0348	1.076e-104	353.0	COG1180@1|root,COG1180@2|Bacteria,2G6B2@200795|Chloroflexi,34D83@301297|Dehalococcoidia	301297|Dehalococcoidia	C	Radical SAM superfamily	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
HKD2_k127_7997242_16	207559.Dde_2680	1.978e-32	145.0	COG2199@1|root,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,42T0Q@68525|delta/epsilon subdivisions,2WUA0@28221|Deltaproteobacteria,2MB3F@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	PFAM GGDEF domain containing protein	-	-	2.7.7.65	ko:K02488	ko02020,ko04112,map02020,map04112	M00511	R08057	-	ko00000,ko00001,ko00002,ko01000,ko02022	-	-	-	GAF_2,GGDEF,Response_reg
HKD2_k127_7997242_10	697303.Thewi_1974	4.46e-63	239.0	COG1145@1|root,COG3290@1|root,COG4624@1|root,COG1145@2|Bacteria,COG3290@2|Bacteria,COG4624@2|Bacteria,1TRB4@1239|Firmicutes,25IYK@186801|Clostridia,42F3K@68295|Thermoanaerobacterales	186801|Clostridia	CT	4Fe-4S ferredoxin	-	-	-	-	-	-	-	-	-	-	-	-	FeS,Fe_hyd_lg_C,Fer4,PAS
HKD2_k127_7997242_13	1232436.CAPF01000053_gene123	4.495e-51	187.0	COG4708@1|root,COG4708@2|Bacteria,2HUQ3@201174|Actinobacteria,4CVD2@84998|Coriobacteriia	84998|Coriobacteriia	S	QueT transporter	-	-	-	-	-	-	-	-	-	-	-	-	QueT
HKD2_k127_7997242_12	1121430.JMLG01000032_gene1660	1.872e-51	206.0	COG2203@1|root,COG3437@1|root,COG4936@1|root,COG2203@2|Bacteria,COG3437@2|Bacteria,COG4936@2|Bacteria,1V7YT@1239|Firmicutes,25ET2@186801|Clostridia,267DC@186807|Peptococcaceae	186801|Clostridia	T	Metal-dependent phosphohydrolase, HD region	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,GGDEF,HD,PAS,PocR,SBP_bac_3
HKD2_k127_7997242_23	35754.JNYJ01000043_gene4599	9.225e-09	57.0	COG0642@1|root,COG2205@2|Bacteria,2HEM6@201174|Actinobacteria,4DGZI@85008|Micromonosporales	201174|Actinobacteria	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	-	-	-	-	-	-	-	-	-	-	CHASE3,HAMP,HATPase_c,HisKA
HKD2_k127_8016449_7	1163408.UU9_00200	3.523e-09	57.0	COG0657@1|root,COG0657@2|Bacteria,1QDQP@1224|Proteobacteria,1RQJR@1236|Gammaproteobacteria,1X5SS@135614|Xanthomonadales	135614|Xanthomonadales	I	Glycosyl hydrolase family 65, N-terminal domain	-	-	3.2.1.51	ko:K15923	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000	-	GH95	-	Glyco_hyd_65N_2
HKD2_k127_8016449_0	471855.Shel_21550	3.069e-181	581.0	COG0112@1|root,COG0112@2|Bacteria,2GK7U@201174|Actinobacteria,4CV8R@84998|Coriobacteriia	84998|Coriobacteriia	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
HKD2_k127_8016449_4	754252.PFREUD_21660	9.042e-46	173.0	COG0698@1|root,COG0698@2|Bacteria,2GKJG@201174|Actinobacteria	201174|Actinobacteria	G	Ribose 5-phosphate isomerase	rpiB	-	5.3.1.6	ko:K01808	ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01056,R09030	RC00376,RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	LacAB_rpiB
HKD2_k127_8016449_3	1111135.HMPREF1248_0218	5.331e-53	194.0	COG0009@1|root,COG0009@2|Bacteria,2GK2X@201174|Actinobacteria,4CW4P@84998|Coriobacteriia	84998|Coriobacteriia	J	Sua5 YciO YrdC YwlC family	-	-	2.7.7.87	ko:K07566	-	-	R10463	RC00745	ko00000,ko01000,ko03009,ko03016	-	-	-	Sua5_yciO_yrdC
HKD2_k127_8016449_2	742818.HMPREF9451_00874	1.323e-78	273.0	COG2890@1|root,COG2890@2|Bacteria,2GMH1@201174|Actinobacteria,4CUEA@84998|Coriobacteriia	84998|Coriobacteriia	J	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif	prmC	-	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS,Methyltransf_31,Sua5_yciO_yrdC
HKD2_k127_8016449_1	1384484.AEQU_1136	2.71e-148	477.0	COG0216@1|root,COG0216@2|Bacteria,2GJWG@201174|Actinobacteria,4CUGQ@84998|Coriobacteriia	84998|Coriobacteriia	J	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA	prfA	-	-	ko:K02835	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
HKD2_k127_8016449_6	163908.KB235896_gene1235	3.284e-21	100.0	COG2337@1|root,COG2337@2|Bacteria,1G5NV@1117|Cyanobacteria,1HNZI@1161|Nostocales	1117|Cyanobacteria	L	Toxic component of a toxin-antitoxin (TA) module	-	-	-	ko:K07171	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PemK_toxin
HKD2_k127_8016449_5	742818.HMPREF9451_01347	5.39e-44	164.0	COG3872@1|root,COG3872@2|Bacteria,2IIWY@201174|Actinobacteria,4CVDS@84998|Coriobacteriia	84998|Coriobacteriia	S	Protein of unknown function (DUF1385)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1385
HKD2_k127_8038014_6	247490.KSU1_C0329	1.517e-99	336.0	COG1042@1|root,COG1042@2|Bacteria,2IXY9@203682|Planctomycetes	203682|Planctomycetes	C	Acyl-CoA synthetase (NDP forming)	-	-	-	ko:K09181	-	-	-	-	ko00000	-	-	-	ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig
HKD2_k127_8038014_10	316274.Haur_3751	1.33e-67	243.0	COG0857@1|root,COG0857@2|Bacteria,2GAB3@200795|Chloroflexi,374UU@32061|Chloroflexia	32061|Chloroflexia	C	PFAM DRTGG domain protein	-	-	-	ko:K06873	-	-	-	-	ko00000	-	-	-	AAA_26,DRTGG
HKD2_k127_8038014_7	1235794.C811_00331	5.415e-98	330.0	COG0416@1|root,COG0416@2|Bacteria,2I8WT@201174|Actinobacteria,4CURT@84998|Coriobacteriia	84998|Coriobacteriia	I	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA	plsX	-	2.3.1.15	ko:K03621	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FA_synthesis
HKD2_k127_8038014_8	555088.DealDRAFT_1964	5.838e-93	329.0	COG0332@1|root,COG0332@2|Bacteria,1TP0K@1239|Firmicutes,248V8@186801|Clostridia,42JKV@68298|Syntrophomonadaceae	186801|Clostridia	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	fabH	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
HKD2_k127_8038014_2	1121472.AQWN01000002_gene2331	9.96e-115	386.0	COG2070@1|root,COG2070@2|Bacteria,1TPC3@1239|Firmicutes,24831@186801|Clostridia,260H0@186807|Peptococcaceae	186801|Clostridia	S	PFAM 2-nitropropane dioxygenase	fabK	-	1.3.1.9	ko:K02371	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00083	R04429,R04724,R04955,R04958,R04961,R04966,R04969,R07765	RC00052,RC00076	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	iHN637.CLJU_RS20775	NMO
HKD2_k127_8038014_11	180281.CPCC7001_2679	4.501e-55	207.0	COG0331@1|root,COG0331@2|Bacteria,1FZZ5@1117|Cyanobacteria,22RUT@167375|Cyanobium	1117|Cyanobacteria	I	Acyl transferase domain	fabD	-	2.3.1.39	ko:K00645	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	M00082	R01626,R11671	RC00004,RC00039,RC02727	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyl_transf_1
HKD2_k127_8038014_9	1200557.JHWV01000001_gene418	2.061e-82	288.0	COG1028@1|root,COG1028@2|Bacteria,1TP76@1239|Firmicutes,4H2JC@909932|Negativicutes	909932|Negativicutes	IQ	reductase	fabG	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HKD2_k127_8038014_13	1051632.TPY_1218	9.088e-28	114.0	COG0236@1|root,COG0236@2|Bacteria,1VEE3@1239|Firmicutes,24QME@186801|Clostridia,3WCPE@538999|Clostridiales incertae sedis	186801|Clostridia	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	acpP	-	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
HKD2_k127_8038014_4	498761.HM1_2167	1.19e-105	353.0	COG2070@1|root,COG2070@2|Bacteria,1TPX1@1239|Firmicutes,247YZ@186801|Clostridia	186801|Clostridia	K	2-nitropropane dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	NMO
HKD2_k127_8038014_1	429009.Adeg_0960	5.413e-151	488.0	COG0304@1|root,COG0304@2|Bacteria,1TPA7@1239|Firmicutes,247VF@186801|Clostridia,42FCV@68295|Thermoanaerobacterales	186801|Clostridia	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	fabF	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
HKD2_k127_8038014_12	562970.Btus_1446	5.833e-49	184.0	COG0571@1|root,COG0571@2|Bacteria,1TPGC@1239|Firmicutes,4HAWU@91061|Bacilli,277WU@186823|Alicyclobacillaceae	91061|Bacilli	J	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism	rnc	GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004525,GO:0004540,GO:0005488,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0032296,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901363	3.1.26.3	ko:K03685	ko03008,ko05205,map03008,map05205	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019,ko03036	-	-	-	Ribonucleas_3_3,dsrm
HKD2_k127_8038014_0	1232436.CAPF01000014_gene637	2.293e-281	905.0	COG1196@1|root,COG1196@2|Bacteria,2GK93@201174|Actinobacteria,4CUK9@84998|Coriobacteriia	84998|Coriobacteriia	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
HKD2_k127_8038014_5	479437.Elen_1371	8.701e-102	355.0	COG0552@1|root,COG0552@2|Bacteria,2GJQH@201174|Actinobacteria,4CU9Q@84998|Coriobacteriia	84998|Coriobacteriia	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)	ftsY	-	-	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2,3.A.5.7	-	-	SRP54,SRP54_N
HKD2_k127_8038014_14	1227349.C170_11110	4.459e-21	107.0	COG0681@1|root,COG0681@2|Bacteria,1V5QJ@1239|Firmicutes,4HHPF@91061|Bacilli,274TX@186822|Paenibacillaceae	91061|Bacilli	U	Belongs to the peptidase S26 family	-	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24
HKD2_k127_8038014_3	742818.HMPREF9451_00699	1.274e-112	370.0	COG0541@1|root,COG0541@2|Bacteria,2GK4R@201174|Actinobacteria,4CUDY@84998|Coriobacteriia	84998|Coriobacteriia	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY	ffh	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
HKD2_k127_8123097_5	1121106.JQKB01000012_gene4682	3.345e-35	154.0	COG0265@1|root,COG0823@1|root,COG2931@1|root,COG0265@2|Bacteria,COG0823@2|Bacteria,COG2931@2|Bacteria	2|Bacteria	Q	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	ko:K08372	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	HemolysinCabind,NACHT,PDZ_2,Trypsin_2,VCBS
HKD2_k127_8123097_6	42256.RradSPS_1542	3.412e-35	139.0	COG1933@1|root,COG1933@2|Bacteria,2GU4W@201174|Actinobacteria,4CQ2Q@84995|Rubrobacteria	84995|Rubrobacteria	L	Double zinc ribbon	-	-	-	-	-	-	-	-	-	-	-	-	DZR
HKD2_k127_8123097_0	502558.EGYY_18690	4.037e-275	859.0	COG0441@1|root,COG0441@2|Bacteria,2GKTC@201174|Actinobacteria,4CUN7@84998|Coriobacteriia	84998|Coriobacteriia	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	-	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD
HKD2_k127_8123097_4	414684.RC1_0433	2.324e-53	207.0	COG0642@1|root,COG2205@2|Bacteria,1MUZQ@1224|Proteobacteria,2TSS7@28211|Alphaproteobacteria,2JPB0@204441|Rhodospirillales	204441|Rhodospirillales	T	Histidine kinase	kdpD	-	2.7.13.3	ko:K07646	ko02020,map02020	M00454	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	DUF4118,GAF_3,HATPase_c,HisKA,KdpD,Usp
HKD2_k127_8123097_3	1535287.JP74_10315	6.735e-67	237.0	COG0745@1|root,COG0745@2|Bacteria,1MWZ5@1224|Proteobacteria,2TV3A@28211|Alphaproteobacteria,3N8C7@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	Transcriptional regulatory protein, C terminal	kdpE	-	-	ko:K07667	ko02020,ko02024,map02020,map02024	M00454	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
HKD2_k127_8123097_2	1380394.JADL01000007_gene4503	1.652e-212	676.0	COG2060@1|root,COG2060@2|Bacteria,1MV1K@1224|Proteobacteria,2TSIJ@28211|Alphaproteobacteria,2JPJD@204441|Rhodospirillales	204441|Rhodospirillales	P	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane	kdpA	-	3.6.3.12	ko:K01546	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	3.A.3.7	-	-	KdpA
HKD2_k127_8123097_1	1267533.KB906735_gene4778	2.024e-248	794.0	COG2216@1|root,COG2216@2|Bacteria,3Y302@57723|Acidobacteria,2JHQI@204432|Acidobacteriia	204432|Acidobacteriia	P	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system	kdpB	-	3.6.3.12	ko:K01547	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	3.A.3.7	-	-	E1-E2_ATPase,Hydrolase
HKD2_k127_8153823_1	1134474.O59_000665	8.289e-31	123.0	2BH9F@1|root,32BAX@2|Bacteria,1NC2G@1224|Proteobacteria,1SDW5@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8153823_0	1472716.KBK24_0131345	1.452e-47	181.0	COG3311@1|root,COG3311@2|Bacteria,1RI96@1224|Proteobacteria,2VNZX@28216|Betaproteobacteria,1K27H@119060|Burkholderiaceae	28216|Betaproteobacteria	K	Prophage cp4-57 regulatory	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_827247_2	471855.Shel_11860	4.396e-103	341.0	COG0044@1|root,COG0044@2|Bacteria,2GJ0T@201174|Actinobacteria,4CU8N@84998|Coriobacteriia	84998|Coriobacteriia	F	Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily	pyrC	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
HKD2_k127_827247_1	502558.EGYY_14690	2.775e-138	459.0	COG0505@1|root,COG0505@2|Bacteria,2GKFA@201174|Actinobacteria,4CVCQ@84998|Coriobacteriia	84998|Coriobacteriia	F	Belongs to the CarA family	carA	-	6.3.5.5	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_sm_chain,GATase
HKD2_k127_827247_0	471855.Shel_13230	9.852e-218	682.0	COG0458@1|root,COG0458@2|Bacteria,2GK5N@201174|Actinobacteria,4CUHZ@84998|Coriobacteriia	84998|Coriobacteriia	F	Belongs to the CarB family	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
HKD2_k127_8692266_9	436229.JOEH01000033_gene3573	7.329e-83	280.0	COG1191@1|root,COG1191@2|Bacteria,2GKBK@201174|Actinobacteria,2NE9K@228398|Streptacidiphilus	201174|Actinobacteria	K	Sigma-70, region 4	whiG	-	-	ko:K02405	ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111	-	-	-	ko00000,ko00001,ko02035,ko03021	-	-	-	Sigma70_r2,Sigma70_r3,Sigma70_r4
HKD2_k127_8692266_23	880072.Desac_2636	2.011e-20	100.0	COG0745@1|root,COG0745@2|Bacteria,1MY2Z@1224|Proteobacteria,42MP1@68525|delta/epsilon subdivisions,2WJPD@28221|Deltaproteobacteria,2MRKV@213462|Syntrophobacterales	28221|Deltaproteobacteria	K	PFAM response regulator receiver	-	-	-	ko:K07657	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
HKD2_k127_8692266_7	697281.Mahau_1914	1.599e-95	320.0	COG0052@1|root,COG0052@2|Bacteria,1TPNA@1239|Firmicutes,247ZR@186801|Clostridia,42ENB@68295|Thermoanaerobacterales	186801|Clostridia	J	Belongs to the universal ribosomal protein uS2 family	rpsB	-	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
HKD2_k127_8692266_8	1034345.CAEM01000014_gene152	1.745e-87	301.0	COG0264@1|root,COG0264@2|Bacteria,2GK4M@201174|Actinobacteria,4CU7J@84998|Coriobacteriia	84998|Coriobacteriia	J	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome	tsf	-	-	ko:K02357	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EF_TS
HKD2_k127_8692266_6	469378.Ccur_10930	1.627e-104	346.0	COG0528@1|root,COG0528@2|Bacteria,2GKWQ@201174|Actinobacteria,4CUD7@84998|Coriobacteriia	84998|Coriobacteriia	F	Catalyzes the reversible phosphorylation of UMP to UDP	pyrH	-	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
HKD2_k127_8692266_12	635013.TherJR_1359	5.562e-65	226.0	COG0233@1|root,COG0233@2|Bacteria,1V1F2@1239|Firmicutes,24HWS@186801|Clostridia,261N9@186807|Peptococcaceae	186801|Clostridia	J	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another	frr	-	-	ko:K02838	-	-	-	-	ko00000,ko03012	-	-	-	RRF
HKD2_k127_8692266_10	429009.Adeg_0583	5.94e-81	276.0	COG0020@1|root,COG0020@2|Bacteria,1TQTS@1239|Firmicutes,247TE@186801|Clostridia,42F7X@68295|Thermoanaerobacterales	186801|Clostridia	H	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids	uppS	-	2.5.1.31	ko:K00806	ko00900,ko01110,map00900,map01110	-	R06447	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
HKD2_k127_8692266_17	445975.COLSTE_01606	1.674e-49	191.0	COG4589@1|root,COG4589@2|Bacteria,2GNWK@201174|Actinobacteria,4CV43@84998|Coriobacteriia	84998|Coriobacteriia	S	Cytidylyltransferase family	cdsA	-	2.7.7.41	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_1
HKD2_k127_8692266_3	649764.HMPREF0762_01840	2.061e-121	411.0	COG0743@1|root,COG0743@2|Bacteria,2GIRV@201174|Actinobacteria,4CUA4@84998|Coriobacteriia	84998|Coriobacteriia	I	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)	dxr	-	1.1.1.267	ko:K00099	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05688	RC01452	ko00000,ko00001,ko00002,ko01000	-	-	-	DXPR_C,DXP_redisom_C,DXP_reductoisom
HKD2_k127_8692266_16	633147.Olsu_0902	1.5e-56	216.0	COG0750@1|root,COG0750@2|Bacteria,2HUFX@201174|Actinobacteria,4CUH9@84998|Coriobacteriia	84998|Coriobacteriia	M	RIP metalloprotease RseP	-	-	-	ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_M50
HKD2_k127_8692266_5	522772.Dacet_0872	1.8e-114	379.0	COG0821@1|root,COG0821@2|Bacteria,2GF8V@200930|Deferribacteres	200930|Deferribacteres	H	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate	ispG	-	1.17.7.1,1.17.7.3	ko:K03526	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R08689,R10859	RC01486	ko00000,ko00001,ko00002,ko01000	-	-	-	GcpE
HKD2_k127_8692266_4	635013.TherJR_1041	2.18e-117	396.0	COG2223@1|root,COG2223@2|Bacteria,1TPR9@1239|Firmicutes,2483N@186801|Clostridia,260AH@186807|Peptococcaceae	186801|Clostridia	P	PFAM Major Facilitator Superfamily	-	-	-	ko:K08177	-	-	-	-	ko00000,ko02000	2.A.1.11	-	-	MFS_1
HKD2_k127_8692266_19	316067.Geob_0907	1.302e-35	142.0	COG4091@1|root,COG4091@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,MCPsignal,NAD_binding_3
HKD2_k127_8692266_1	1384484.AEQU_0159	2.14e-224	711.0	COG0442@1|root,COG0442@2|Bacteria,2GJ9G@201174|Actinobacteria,4CUIZ@84998|Coriobacteriia	84998|Coriobacteriia	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS	proS	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA_edit
HKD2_k127_8692266_20	1235794.C811_00450	1.036e-33	138.0	COG0779@1|root,COG0779@2|Bacteria,2HUVT@201174|Actinobacteria,4CVTM@84998|Coriobacteriia	84998|Coriobacteriia	J	Required for maturation of 30S ribosomal subunits	rimP	-	-	ko:K09748	-	-	-	-	ko00000,ko03009	-	-	-	DUF150,DUF150_C
HKD2_k127_8692266_2	479437.Elen_1812	2.063e-137	446.0	COG0195@1|root,COG0195@2|Bacteria,2GJDJ@201174|Actinobacteria,4CUWV@84998|Coriobacteriia	84998|Coriobacteriia	K	Participates in both transcription termination and antitermination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KH_5,NusA_N
HKD2_k127_8692266_24	515635.Dtur_1207	5.488e-19	89.0	COG2740@1|root,COG2740@2|Bacteria	2|Bacteria	K	Nucleic-acid-binding protein implicated in transcription termination	ylxR	-	-	ko:K02600,ko:K07742	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	DUF448
HKD2_k127_8692266_0	1235794.C811_00453	2.291e-265	839.0	COG0532@1|root,COG0532@2|Bacteria,2GKPH@201174|Actinobacteria,4CUAY@84998|Coriobacteriia	84998|Coriobacteriia	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,GTP_EFTU_D2,IF-2,IF2_N
HKD2_k127_8692266_22	469383.Cwoe_3223	1.903e-24	107.0	COG0858@1|root,COG0858@2|Bacteria,2HPFC@201174|Actinobacteria,4CQTS@84995|Rubrobacteria	84995|Rubrobacteria	J	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA	rbfA	-	-	ko:K02834	-	-	-	-	ko00000,ko03009	-	-	-	RBFA
HKD2_k127_8692266_14	1235794.C811_00461	1.029e-60	222.0	COG0618@1|root,COG0618@2|Bacteria,2GN9Z@201174|Actinobacteria,4CUKD@84998|Coriobacteriia	84998|Coriobacteriia	S	DHHA1 domain	-	-	3.1.13.3,3.1.3.7	ko:K06881	ko00920,ko01100,ko01120,map00920,map01100,map01120	-	R00188,R00508	RC00078	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
HKD2_k127_8692266_13	1384484.AEQU_0968	8.008e-62	235.0	COG0130@1|root,COG0130@2|Bacteria,2GJZK@201174|Actinobacteria,4CUJN@84998|Coriobacteriia	84998|Coriobacteriia	J	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs	truB	-	5.4.99.25	ko:K03177	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruB_C_2,TruB_N
HKD2_k127_8692266_15	742742.HMPREF9452_00520	1.657e-58	220.0	COG0196@1|root,COG0196@2|Bacteria,2GKQF@201174|Actinobacteria,4CUHV@84998|Coriobacteriia	84998|Coriobacteriia	H	riboflavin biosynthesis protein	ribF	-	2.7.1.26,2.7.7.2	ko:K11753	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00161,R00549	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_syn,Flavokinase
HKD2_k127_8692266_21	1043493.BBLU01000018_gene1586	1.926e-31	132.0	COG0716@1|root,COG0716@2|Bacteria	2|Bacteria	C	FMN binding	-	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_1,Flavodoxin_5
HKD2_k127_8692266_18	398512.JQKC01000005_gene5620	1.567e-41	171.0	COG4908@1|root,COG4908@2|Bacteria,1V0U5@1239|Firmicutes,25D3E@186801|Clostridia,3WK8S@541000|Ruminococcaceae	186801|Clostridia	S	Condensation domain	-	-	-	-	-	-	-	-	-	-	-	-	Condensation
HKD2_k127_8692266_11	867903.ThesuDRAFT_00051	2.258e-67	247.0	COG0438@1|root,COG0438@2|Bacteria,1TPTA@1239|Firmicutes,24ANI@186801|Clostridia,3WD9P@538999|Clostridiales incertae sedis	186801|Clostridia	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
HKD2_k127_8693695_3	502558.EGYY_19070	8.951e-55	199.0	COG0127@1|root,COG0127@2|Bacteria,2GM2B@201174|Actinobacteria,4CUUU@84998|Coriobacteriia	84998|Coriobacteriia	F	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions	rdgB	-	3.6.1.66	ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000	-	-	-	Ham1p_like
HKD2_k127_8693695_1	742818.HMPREF9451_01075	1.268e-88	299.0	COG0689@1|root,COG0689@2|Bacteria,2GJFI@201174|Actinobacteria,4CU90@84998|Coriobacteriia	84998|Coriobacteriia	J	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates	rph	-	2.7.7.56	ko:K00989	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RNase_PH,RNase_PH_C
HKD2_k127_8693695_4	1385519.N801_03510	1.816e-32	138.0	COG1234@1|root,COG1234@2|Bacteria,2GMEX@201174|Actinobacteria,4FFHA@85021|Intrasporangiaceae	201174|Actinobacteria	S	Metal-dependent hydrolase	yhfI	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0031123,GO:0034414,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0042779,GO:0042780,GO:0042781,GO:0043170,GO:0043628,GO:0044237,GO:0044238,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1905267	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
HKD2_k127_8693695_0	1235794.C811_00862	3.549e-96	326.0	COG0796@1|root,COG0796@2|Bacteria,2GN4I@201174|Actinobacteria,4CVD5@84998|Coriobacteriia	84998|Coriobacteriia	M	Provides the (R)-glutamate required for cell wall biosynthesis	murI	-	5.1.1.3	ko:K01776	ko00471,ko01100,map00471,map01100	-	R00260	RC00302	ko00000,ko00001,ko01000,ko01011	-	-	-	Asp_Glu_race
HKD2_k127_8693695_2	1229172.JQFA01000004_gene1648	1.799e-65	234.0	COG2201@1|root,COG2201@2|Bacteria,1G1EA@1117|Cyanobacteria,1H8DX@1150|Oscillatoriales	1117|Cyanobacteria	NT	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR	cheB	-	3.1.1.61,3.5.1.44	ko:K03412	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest,Response_reg
HKD2_k127_8991112_1	632335.Calkr_0128	1.423e-232	730.0	COG0330@1|root,COG0330@2|Bacteria,1UY1Y@1239|Firmicutes,24C8M@186801|Clostridia	186801|Clostridia	O	PFAM Band 7 protein	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
HKD2_k127_8991112_13	1408226.T233_01534	2.583e-07	58.0	2D5AS@1|root,32TIN@2|Bacteria,1VA4E@1239|Firmicutes,4HMJT@91061|Bacilli,4B3CM@81852|Enterococcaceae	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_B561
HKD2_k127_8991112_8	1303518.CCALI_00427	2.574e-26	113.0	COG0745@1|root,COG0745@2|Bacteria	1303518.CCALI_00427|-	T	phosphorelay signal transduction system	-	-	-	ko:K07658	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	-
HKD2_k127_8991112_2	552811.Dehly_0763	3.575e-173	558.0	COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,2G8XD@200795|Chloroflexi,34CY9@301297|Dehalococcoidia	301297|Dehalococcoidia	H	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source	nadE	-	6.3.5.1	ko:K01950	ko00760,ko01100,map00760,map01100	M00115	R00257	RC00010,RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase,NAD_synthase
HKD2_k127_8991112_10	290402.Cbei_4090	7.788e-11	74.0	COG2153@1|root,COG2153@2|Bacteria,1UI7Y@1239|Firmicutes,24KCF@186801|Clostridia,36KCZ@31979|Clostridiaceae	186801|Clostridia	S	PFAM GCN5-related N-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_10
HKD2_k127_8991112_3	742818.HMPREF9451_00099	1.077e-152	489.0	COG1830@1|root,COG1830@2|Bacteria,2I9V1@201174|Actinobacteria,4CUCN@84998|Coriobacteriia	84998|Coriobacteriia	G	DeoC/LacD family aldolase	-	-	4.1.2.13	ko:K11645	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	DeoC
HKD2_k127_8991112_6	82654.Pse7367_1315	4.578e-84	289.0	COG0777@1|root,COG0777@2|Bacteria,1G1ZY@1117|Cyanobacteria,1H79W@1150|Oscillatoriales	1117|Cyanobacteria	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA	accD	-	2.1.3.15,6.4.1.2	ko:K01963	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	iJN678.accD	Carboxyl_trans
HKD2_k127_8991112_5	1297742.A176_00494	7.156e-102	344.0	COG0825@1|root,COG0825@2|Bacteria,1MURN@1224|Proteobacteria,42NC2@68525|delta/epsilon subdivisions,2WKA3@28221|Deltaproteobacteria,2YU4X@29|Myxococcales	28221|Deltaproteobacteria	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA	accA	-	2.1.3.15,6.4.1.2	ko:K01962,ko:K01963	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	ACCA
HKD2_k127_8991112_4	1192034.CAP_1628	2.239e-122	407.0	COG0205@1|root,COG0205@2|Bacteria,1R560@1224|Proteobacteria,42P6N@68525|delta/epsilon subdivisions,2WINA@28221|Deltaproteobacteria,2YVFG@29|Myxococcales	28221|Deltaproteobacteria	H	Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions	pfp	-	2.7.1.11,2.7.1.90	ko:K00895,ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
HKD2_k127_8991112_7	1120746.CCNL01000009_gene869	2.624e-41	169.0	COG2608@1|root,COG2836@1|root,COG4633@1|root,COG2608@2|Bacteria,COG2836@2|Bacteria,COG4633@2|Bacteria,2NQCH@2323|unclassified Bacteria	2|Bacteria	P	Cytochrome C biogenesis protein transmembrane region	silP	-	1.9.3.1,3.6.3.54	ko:K02275,ko:K09792,ko:K17686	ko00190,ko01100,ko01524,ko04016,map00190,map01100,map01524,map04016	M00155	R00081,R00086	RC00002,RC00016	ko00000,ko00001,ko00002,ko01000	3.A.3.5,3.D.4.2,3.D.4.4,3.D.4.6	-	-	Cupredoxin_1,DsbD_2,Ferric_reduct,HMA
HKD2_k127_8991112_9	1136177.KCA1_2503	1.134e-11	74.0	COG4633@1|root,COG4633@2|Bacteria,1W06G@1239|Firmicutes,4HZAG@91061|Bacilli,3F7FA@33958|Lactobacillaceae	91061|Bacilli	S	Cupredoxin-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupredoxin_1
HKD2_k127_8991112_11	35760.BCHO_1609	4.387e-10	72.0	COG2217@1|root,COG2217@2|Bacteria,2GIRF@201174|Actinobacteria,4CZ24@85004|Bifidobacteriales	201174|Actinobacteria	P	E1-E2 ATPase	-	-	3.6.3.4,3.6.3.54	ko:K01533,ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	Cupredoxin_1,E1-E2_ATPase,HMA,Hydrolase,YHS
HKD2_k127_8991112_0	1121422.AUMW01000020_gene1702	5.704e-242	786.0	COG2217@1|root,COG2217@2|Bacteria,1TP5S@1239|Firmicutes,247MW@186801|Clostridia,2608V@186807|Peptococcaceae	186801|Clostridia	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	copA	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
HKD2_k127_8991112_12	323261.Noc_2920	2.27e-08	66.0	2AF5T@1|root,32BJG@2|Bacteria,1QW3V@1224|Proteobacteria,1STRP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9022459_11	561175.KB894096_gene390	6.359e-30	121.0	COG0025@1|root,COG0025@2|Bacteria,2I2S7@201174|Actinobacteria,4EQYS@85012|Streptosporangiales	201174|Actinobacteria	P	Zn-finger in ubiquitin-hydrolases and other protein	-	-	-	-	-	-	-	-	-	-	-	-	zf-UBP
HKD2_k127_9022459_3	683837.lse_2461	1.122e-70	262.0	COG0438@1|root,COG0438@2|Bacteria,1TPTA@1239|Firmicutes,4HA41@91061|Bacilli,26JPN@186820|Listeriaceae	91061|Bacilli	M	1,2-diacylglycerol 3-glucosyltransferase	-	-	2.4.1.337	ko:K19002	ko00561,ko01100,map00561,map01100	-	R10850	RC00005,RC00059	ko00000,ko00001,ko01000,ko01003	-	GT4	-	Glyco_transf_4,Glycos_transf_1
HKD2_k127_9022459_9	1173026.Glo7428_0480	1.377e-33	138.0	COG2020@1|root,COG2020@2|Bacteria,1G57G@1117|Cyanobacteria	1117|Cyanobacteria	O	PFAM Isoprenylcysteine carboxyl methyltransferase (ICMT) family	-	-	-	-	-	-	-	-	-	-	-	-	ICMT
HKD2_k127_9022459_13	1121438.JNJA01000009_gene4184	5.824e-25	113.0	COG1309@1|root,COG1309@2|Bacteria,1RDYN@1224|Proteobacteria,4368M@68525|delta/epsilon subdivisions,2X0T1@28221|Deltaproteobacteria,2MDBP@213115|Desulfovibrionales	28221|Deltaproteobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
HKD2_k127_9022459_7	1487953.JMKF01000053_gene1912	1.065e-65	232.0	COG1136@1|root,COG1136@2|Bacteria,1G4GN@1117|Cyanobacteria,1HH6B@1150|Oscillatoriales	1117|Cyanobacteria	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K02003,ko:K09810	ko02010,map02010	M00255,M00258	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.125	-	-	ABC_tran
HKD2_k127_9022459_2	1238182.C882_0659	5.284e-90	325.0	COG0577@1|root,COG0577@2|Bacteria,1MW6D@1224|Proteobacteria,2TTJZ@28211|Alphaproteobacteria,2JR80@204441|Rhodospirillales	204441|Rhodospirillales	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HKD2_k127_9022459_10	1032480.MLP_38300	3.318e-31	130.0	29KMP@1|root,307IZ@2|Bacteria,2GWIU@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4287
HKD2_k127_9022459_8	1122919.KB905582_gene3741	1.401e-37	149.0	COG1247@1|root,COG1247@2|Bacteria,1V6X5@1239|Firmicutes,4HIP1@91061|Bacilli,274WU@186822|Paenibacillaceae	91061|Bacilli	M	Acetyltransferase (GNAT) domain	pat	-	2.3.1.183	ko:K03823	ko00440,ko01130,map00440,map01130	-	R08871,R08938	RC00004,RC00064	ko00000,ko00001,ko01000	-	-	-	Acetyltransf_4
HKD2_k127_9022459_4	644283.Micau_2889	3.165e-70	250.0	COG1801@1|root,COG1801@2|Bacteria,2HU1R@201174|Actinobacteria,4DADR@85008|Micromonosporales	201174|Actinobacteria	S	Protein of unknown function DUF72	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
HKD2_k127_9022459_5	75379.Tint_2864	4.693e-70	244.0	COG1136@1|root,COG1136@2|Bacteria,1MVSQ@1224|Proteobacteria,2WEGN@28216|Betaproteobacteria,1KKYV@119065|unclassified Burkholderiales	28216|Betaproteobacteria	V	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner	-	-	-	ko:K09810	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.125	-	-	ABC_tran
HKD2_k127_9022459_6	1286171.EAL2_c21260	2.645e-67	246.0	COG4591@1|root,COG4591@2|Bacteria,1TQ8J@1239|Firmicutes,24BJ2@186801|Clostridia	186801|Clostridia	M	ABC-type transport system involved in lipoprotein release permease component	-	-	-	ko:K09808	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.125	-	-	FtsX,MacB_PCD
HKD2_k127_9022459_15	1307759.JOMJ01000003_gene1218	1.129e-18	96.0	COG5012@1|root,COG5012@2|Bacteria,1RE0V@1224|Proteobacteria,42VZ0@68525|delta/epsilon subdivisions,2WRFJ@28221|Deltaproteobacteria,2MBN9@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Cobalamin B12-binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,B12-binding_2
HKD2_k127_9022459_1	335543.Sfum_1473	4.848e-117	392.0	COG0282@1|root,COG0282@2|Bacteria,1MW61@1224|Proteobacteria,42MJA@68525|delta/epsilon subdivisions,2WJBJ@28221|Deltaproteobacteria,2MR0D@213462|Syntrophobacterales	28221|Deltaproteobacteria	F	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction	ackA	-	2.7.2.1	ko:K00925	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00315,R01353	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetate_kinase
HKD2_k127_9022459_0	65093.PCC7418_1447	0.0	1311.0	COG3957@1|root,COG3957@2|Bacteria,1G0B2@1117|Cyanobacteria	1117|Cyanobacteria	G	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase	-	-	4.1.2.22,4.1.2.9	ko:K01621	ko00030,ko00710,ko01100,ko01120,map00030,map00710,map01100,map01120	-	R00761,R01621	RC00032,RC00226	ko00000,ko00001,ko01000	-	-	-	XFP,XFP_C,XFP_N
HKD2_k127_9022459_16	1123400.KB904817_gene1444	8.7e-08	64.0	COG3187@1|root,COG3187@2|Bacteria,1NGG1@1224|Proteobacteria,1T10Q@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	META domain	-	-	-	ko:K03668	-	-	-	-	ko00000	-	-	-	META
HKD2_k127_9022459_12	1313172.YM304_09590	1.063e-26	122.0	COG3764@1|root,COG3764@2|Bacteria,2GKT6@201174|Actinobacteria,4CNXW@84992|Acidimicrobiia	84992|Acidimicrobiia	M	Sortase family	-	-	3.4.22.70	ko:K07284	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Sortase
HKD2_k127_9022459_14	1303518.CCALI_01897	1.204e-21	110.0	COG1595@1|root,COG1595@2|Bacteria	1303518.CCALI_01897|-	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	-
HKD2_k127_9063833_3	648757.Rvan_0633	1.416e-100	348.0	COG1793@1|root,COG3285@1|root,COG1793@2|Bacteria,COG3285@2|Bacteria,1MVWY@1224|Proteobacteria,2TRSZ@28211|Alphaproteobacteria,3N6F4@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	DNA ligase	-	-	6.5.1.1	ko:K01971	ko03450,map03450	-	R00381	RC00005	ko00000,ko00001,ko01000,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,LigD_N
HKD2_k127_9063833_5	1254432.SCE1572_15910	6.469e-74	258.0	COG1273@1|root,COG1273@2|Bacteria,1N4UX@1224|Proteobacteria,42RD5@68525|delta/epsilon subdivisions,2WMZ1@28221|Deltaproteobacteria,2YV5B@29|Myxococcales	28221|Deltaproteobacteria	L	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD	ku	-	-	ko:K10979	ko03450,map03450	-	-	-	ko00000,ko00001,ko03400	-	-	-	Ku
HKD2_k127_9063833_12	935848.JAEN01000015_gene2484	6.176e-07	57.0	COG1846@1|root,COG1846@2|Bacteria,1Q3R7@1224|Proteobacteria,2U6VP@28211|Alphaproteobacteria,2PWZV@265|Paracoccus	28211|Alphaproteobacteria	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	MarR_2
HKD2_k127_9063833_7	713586.KB900536_gene1310	6.315e-63	220.0	COG0590@1|root,COG0590@2|Bacteria,1RHM4@1224|Proteobacteria,1S4RE@1236|Gammaproteobacteria,1WY1Y@135613|Chromatiales	135613|Chromatiales	FJ	CMP dCMP deaminase, zinc-binding	-	-	3.5.4.3	ko:K01487	ko00230,ko01100,map00230,map01100	-	R01676	RC00204	ko00000,ko00001,ko01000	-	-	-	dCMP_cyt_deam_1
HKD2_k127_9063833_0	1321773.HMPREF9069_00165	0.0	1097.0	COG0542@1|root,COG0542@2|Bacteria,2GJ73@201174|Actinobacteria,4CV0R@84998|Coriobacteriia	84998|Coriobacteriia	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpB	-	-	ko:K03695	ko04213,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
HKD2_k127_9063833_10	1232436.CAPF01000077_gene1075	6.09e-28	119.0	COG0789@1|root,COG0789@2|Bacteria,2GR1T@201174|Actinobacteria,4CVZ7@84998|Coriobacteriia	84998|Coriobacteriia	K	Transcriptional regulator, MerR family	-	-	-	ko:K13640	-	-	-	-	ko00000,ko03000	-	-	-	MerR_1
HKD2_k127_9063833_4	1196835.A458_04065	1.717e-94	321.0	COG0484@1|root,COG0484@2|Bacteria,1MVMS@1224|Proteobacteria,1RNHY@1236|Gammaproteobacteria,1Z17N@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	GO:0006457,GO:0008150,GO:0009987	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
HKD2_k127_9063833_9	1203602.HMPREF1527_00972	7.011e-35	140.0	COG0576@1|root,COG0576@2|Bacteria,2GP4F@201174|Actinobacteria,4CVNG@84998|Coriobacteriia	84998|Coriobacteriia	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	grpE	-	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
HKD2_k127_9063833_1	479437.Elen_3072	8.37e-301	938.0	COG0443@1|root,COG0443@2|Bacteria,2GJTY@201174|Actinobacteria,4CU7E@84998|Coriobacteriia	84998|Coriobacteriia	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
HKD2_k127_9063833_11	502558.EGYY_28940	9.833e-22	96.0	COG1149@1|root,COG1149@2|Bacteria,2I6RQ@201174|Actinobacteria,4CYMA@84998|Coriobacteriia	84998|Coriobacteriia	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
HKD2_k127_9063833_13	445975.COLSTE_00963	7.713e-06	58.0	2F4DY@1|root,33X48@2|Bacteria,2HTH7@201174|Actinobacteria,4CVZQ@84998|Coriobacteriia	84998|Coriobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9063833_6	469383.Cwoe_5315	2.027e-67	241.0	COG0451@1|root,COG0451@2|Bacteria,2I2UT@201174|Actinobacteria,4CRA0@84995|Rubrobacteria	84995|Rubrobacteria	M	NAD-dependent epimerase dehydratase	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	GDP_Man_Dehyd
HKD2_k127_9063833_8	1380390.JIAT01000010_gene3639	1.626e-35	145.0	COG3764@1|root,COG3764@2|Bacteria,2GKT6@201174|Actinobacteria,4CS9B@84995|Rubrobacteria	84995|Rubrobacteria	M	Sortase family	-	-	-	-	-	-	-	-	-	-	-	-	Sortase
HKD2_k127_9063833_2	635013.TherJR_2560	2.199e-227	715.0	COG0466@1|root,COG0466@2|Bacteria,1TNYG@1239|Firmicutes,247SH@186801|Clostridia,260BY@186807|Peptococcaceae	186801|Clostridia	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
HKD2_k127_9166368_4	1304284.L21TH_2143	6.318e-78	272.0	COG4656@1|root,COG4656@2|Bacteria,1TPCC@1239|Firmicutes,24805@186801|Clostridia,36F8C@31979|Clostridiaceae	186801|Clostridia	C	Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily	rnfC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03615	-	-	-	-	ko00000	-	-	-	Complex1_51K,Fer4,Fer4_10,Fer4_7,Fer4_9,RnfC_N,SLBB
HKD2_k127_9166368_2	479437.Elen_1256	4.639e-129	426.0	COG3259@1|root,COG3259@2|Bacteria,2GQ33@201174|Actinobacteria,4CVBM@84998|Coriobacteriia	84998|Coriobacteriia	C	Nickel-dependent hydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	NiFeSe_Hases
HKD2_k127_9166368_5	479437.Elen_1255	1.84e-74	257.0	COG1941@1|root,COG1941@2|Bacteria,2GSPN@201174|Actinobacteria,4CUTN@84998|Coriobacteriia	84998|Coriobacteriia	C	NADH ubiquinone oxidoreductase, 20 Kd subunit	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_q6
HKD2_k127_9166368_1	1034345.CAEM01000023_gene834	1.991e-141	458.0	COG0543@1|root,COG0543@2|Bacteria,2HXFY@201174|Actinobacteria,4CV8F@84998|Coriobacteriia	84998|Coriobacteriia	C	Oxidoreductase NAD-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	DHODB_Fe-S_bind,FAD_binding_6,NAD_binding_1
HKD2_k127_9166368_3	742818.HMPREF9451_01061	8.816e-102	342.0	COG0479@1|root,COG0479@2|Bacteria,2I37A@201174|Actinobacteria,4CUEB@84998|Coriobacteriia	84998|Coriobacteriia	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_22
HKD2_k127_9166368_6	1121866.AUGK01000011_gene543	2.171e-56	201.0	COG0105@1|root,COG0105@2|Bacteria,2IFBU@201174|Actinobacteria,4CVPI@84998|Coriobacteriia	84998|Coriobacteriia	F	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate	ndk	-	2.7.4.6	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	M00049,M00050,M00052,M00053	R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895	RC00002	ko00000,ko00001,ko00002,ko01000,ko04131	-	-	-	NDK
HKD2_k127_9166368_7	936550.HMPREF1492_0756	1.447e-48	190.0	COG0457@1|root,COG0457@2|Bacteria,2HUGG@201174|Actinobacteria,4CUIP@84998|Coriobacteriia	84998|Coriobacteriia	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_12,TPR_16,TPR_6,TPR_7,TPR_8
HKD2_k127_9166368_8	1121405.dsmv_1158	2.308e-36	151.0	COG0652@1|root,COG0652@2|Bacteria,1R4KH@1224|Proteobacteria,42R08@68525|delta/epsilon subdivisions,2WWSG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	-	-	5.2.1.8	ko:K01802,ko:K03768	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Pro_isomerase
HKD2_k127_9166368_0	502558.EGYY_21920	1.144e-255	808.0	COG0480@1|root,COG0480@2|Bacteria,2GKRU@201174|Actinobacteria,4CUIA@84998|Coriobacteriia	84998|Coriobacteriia	J	elongation factor G	-	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
HKD2_k127_9169146_12	394221.Mmar10_0416	1.739e-09	63.0	COG3847@1|root,COG3847@2|Bacteria,1NGVU@1224|Proteobacteria,2UJE8@28211|Alphaproteobacteria,43YY0@69657|Hyphomonadaceae	28211|Alphaproteobacteria	U	Flp/Fap pilin component	-	-	-	ko:K02651	ko04112,map04112	-	-	-	ko00000,ko00001,ko02035,ko02044	-	-	-	Flp_Fap
HKD2_k127_9169146_13	1172188.KB911826_gene231	1.95e-06	59.0	COG3847@1|root,COG3847@2|Bacteria,2GX2Y@201174|Actinobacteria,4FI4I@85021|Intrasporangiaceae	201174|Actinobacteria	U	Flp/Fap pilin component	-	-	-	ko:K02651	ko04112,map04112	-	-	-	ko00000,ko00001,ko02035,ko02044	-	-	-	Flp_Fap
HKD2_k127_9169146_9	146922.JOFU01000029_gene5307	9.356e-47	187.0	COG2197@1|root,COG2197@2|Bacteria,2GJ46@201174|Actinobacteria	201174|Actinobacteria	T	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HKD2_k127_9169146_10	1463901.JOIY01000047_gene3338	1.314e-40	166.0	COG2203@1|root,COG4585@1|root,COG2203@2|Bacteria,COG4585@2|Bacteria,2I312@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K02480	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	GAF_2,HATPase_c,HisKA_3
HKD2_k127_9169146_0	1232436.CAPF01000096_gene73	6.869e-230	729.0	COG0465@1|root,COG0465@2|Bacteria,2GJ4Q@201174|Actinobacteria,4CV6C@84998|Coriobacteriia	84998|Coriobacteriia	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
HKD2_k127_9169146_7	1121472.AQWN01000002_gene2260	6.63e-67	244.0	COG0634@1|root,COG0634@2|Bacteria,1V1C9@1239|Firmicutes,24FR4@186801|Clostridia,261JF@186807|Peptococcaceae	186801|Clostridia	F	Belongs to the purine pyrimidine phosphoribosyltransferase family	hpt	-	2.4.2.8	ko:K00760	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	-	R00190,R01132,R01229,R02142,R08237,R08238,R08245	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	Pribosyltran
HKD2_k127_9169146_4	1125712.HMPREF1316_2588	1.941e-75	271.0	COG0037@1|root,COG0037@2|Bacteria,2HUKM@201174|Actinobacteria,4CV1G@84998|Coriobacteriia	84998|Coriobacteriia	J	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine	tilS	-	6.3.4.19	ko:K04075	-	-	R09597	RC02633,RC02634	ko00000,ko01000,ko03016	-	-	-	ATP_bind_3,TilS_C
HKD2_k127_9169146_14	378806.STAUR_4283	9.277e-06	57.0	COG4395@1|root,COG4395@2|Bacteria,1NKJZ@1224|Proteobacteria,43793@68525|delta/epsilon subdivisions,2X2CB@28221|Deltaproteobacteria,2YYKJ@29|Myxococcales	28221|Deltaproteobacteria	S	Tim44	-	-	-	-	-	-	-	-	-	-	-	-	Tim44
HKD2_k127_9169146_6	502025.Hoch_4151	1.14e-67	244.0	COG4260@1|root,COG4260@2|Bacteria,1MXTD@1224|Proteobacteria,42P7D@68525|delta/epsilon subdivisions,2WJ6S@28221|Deltaproteobacteria,2YUUH@29|Myxococcales	28221|Deltaproteobacteria	S	SPFH domain-Band 7 family	-	-	-	-	-	-	-	-	-	-	-	-	Band_7_1,DUF4339,DZR,SHOCT,zinc_ribbon_2
HKD2_k127_9169146_11	215803.DB30_0544	4.979e-21	105.0	COG4395@1|root,COG4395@2|Bacteria,1NKJZ@1224|Proteobacteria,43793@68525|delta/epsilon subdivisions,2X2CB@28221|Deltaproteobacteria,2YYKJ@29|Myxococcales	28221|Deltaproteobacteria	S	Tim44	-	-	-	-	-	-	-	-	-	-	-	-	Tim44
HKD2_k127_9169146_8	1379270.AUXF01000004_gene3236	2.416e-48	191.0	COG0402@1|root,COG0402@2|Bacteria,1ZSMH@142182|Gemmatimonadetes	142182|Gemmatimonadetes	F	Amidohydrolase family	-	-	3.5.4.28,3.5.4.31,3.5.4.40	ko:K12960,ko:K20810	ko00130,ko00270,ko01100,ko01110,map00130,map00270,map01100,map01110	-	R09660,R10695	RC00477	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
HKD2_k127_9169146_2	352165.HMPREF7215_1333	1.931e-88	302.0	COG0410@1|root,COG0410@2|Bacteria,3TC4B@508458|Synergistetes	508458|Synergistetes	E	ATPases associated with a variety of cellular activities	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
HKD2_k127_9169146_1	641491.DND132_2651	7.58e-93	312.0	COG0411@1|root,COG0411@2|Bacteria,1MUTY@1224|Proteobacteria,42NMG@68525|delta/epsilon subdivisions,2WJIS@28221|Deltaproteobacteria,2M8EX@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	PFAM ABC transporter related	livG	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
HKD2_k127_9169146_5	1123499.KB908030_gene608	1.944e-73	261.0	COG4177@1|root,COG4177@2|Bacteria,1MV66@1224|Proteobacteria,2VH43@28216|Betaproteobacteria,2KPXB@206351|Neisseriales	206351|Neisseriales	E	Branched-chain amino acid transport system / permease component	livM	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HKD2_k127_9169146_3	671143.DAMO_1397	7.361e-81	282.0	COG0559@1|root,COG0559@2|Bacteria,2NP7Z@2323|unclassified Bacteria	2|Bacteria	E	Branched-chain amino acid transport system / permease component	livH	GO:0003333,GO:0003674,GO:0005215,GO:0005304,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015173,GO:0015175,GO:0015179,GO:0015188,GO:0015190,GO:0015192,GO:0015238,GO:0015318,GO:0015658,GO:0015711,GO:0015801,GO:0015803,GO:0015804,GO:0015807,GO:0015818,GO:0015820,GO:0015823,GO:0015829,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0042221,GO:0042493,GO:0043090,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0089718,GO:0098655,GO:0098656,GO:0098657,GO:0098713,GO:0098739,GO:1902475,GO:1903714,GO:1903785,GO:1903825,GO:1905039	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	iJN746.PP_4866,iSFV_1184.SFV_3460,iSF_1195.SF3475,iSFxv_1172.SFxv_3791,iS_1188.S4288	BPD_transp_2
HKD2_k127_9343739_0	290397.Adeh_0784	8.83e-172	558.0	COG1793@1|root,COG3285@1|root,COG1793@2|Bacteria,COG3285@2|Bacteria,1MVWY@1224|Proteobacteria,42U99@68525|delta/epsilon subdivisions,2WQ5W@28221|Deltaproteobacteria,2YWMR@29|Myxococcales	28221|Deltaproteobacteria	L	ATP dependent DNA ligase domain protein	-	-	6.5.1.1	ko:K01971	ko03450,map03450	-	R00381	RC00005	ko00000,ko00001,ko01000,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M
HKD2_k127_9343739_2	398767.Glov_2052	7.628e-126	417.0	COG1322@1|root,COG1322@2|Bacteria,1MWHV@1224|Proteobacteria,42PVW@68525|delta/epsilon subdivisions,2WIMX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	RmuC family	-	-	-	ko:K09760	-	-	-	-	ko00000	-	-	-	RmuC
HKD2_k127_9343739_6	563192.HMPREF0179_01871	2.944e-21	97.0	2DBJQ@1|root,32TXM@2|Bacteria,1NYZU@1224|Proteobacteria,430QH@68525|delta/epsilon subdivisions,2WW08@28221|Deltaproteobacteria,2MCPA@213115|Desulfovibrionales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_excise
HKD2_k127_9343739_5	1499967.BAYZ01000171_gene5600	3.08e-27	116.0	COG0071@1|root,COG0071@2|Bacteria,2NPWF@2323|unclassified Bacteria	2|Bacteria	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
HKD2_k127_9343739_4	479433.Caci_0871	9.157e-43	167.0	COG2346@1|root,COG3369@1|root,COG3592@1|root,COG2346@2|Bacteria,COG3369@2|Bacteria,COG3592@2|Bacteria,2I95U@201174|Actinobacteria	201174|Actinobacteria	S	Iron-binding zinc finger CDGSH type	-	-	-	-	-	-	-	-	-	-	-	-	Bac_globin,Fer4_19,zf-CDGSH
HKD2_k127_9343739_8	1191523.MROS_1111	1.735e-09	64.0	COG4309@1|root,COG4309@2|Bacteria	2|Bacteria	D	conserved protein (DUF2249)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1858,DUF2249
HKD2_k127_9343739_3	484770.UFO1_1182	2.927e-88	300.0	COG1136@1|root,COG1136@2|Bacteria,1TP6H@1239|Firmicutes,4H387@909932|Negativicutes	909932|Negativicutes	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD2_k127_9343739_1	484770.UFO1_1183	2.589e-157	526.0	COG0577@1|root,COG0577@2|Bacteria,1U388@1239|Firmicutes,4H32X@909932|Negativicutes	909932|Negativicutes	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HKD2_k127_9343739_7	246194.CHY_2551	1.147e-19	101.0	COG0356@1|root,COG0356@2|Bacteria,1TQIT@1239|Firmicutes,24A6Q@186801|Clostridia,42GZF@68295|Thermoanaerobacterales	186801|Clostridia	C	it plays a direct role in the translocation of protons across the membrane	atpB	-	-	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1	-	-	ATP-synt_A
HKD2_k127_9376687_4	370438.PTH_1596	3.16e-53	203.0	COG2203@1|root,COG2206@1|root,COG2203@2|Bacteria,COG2206@2|Bacteria,1UZN2@1239|Firmicutes,248SE@186801|Clostridia,261QQ@186807|Peptococcaceae	186801|Clostridia	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HD
HKD2_k127_9376687_10	1118060.CAGZ01000024_gene715	4.937e-23	101.0	COG0227@1|root,COG0227@2|Bacteria,2GQNU@201174|Actinobacteria,4CWH3@84998|Coriobacteriia	84998|Coriobacteriia	J	Belongs to the bacterial ribosomal protein bL28 family	rpmB	-	-	ko:K02902	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L28
HKD2_k127_9376687_13	1232428.CAVO010000071_gene505	0.0001376	51.0	2DNM3@1|root,32Y2K@2|Bacteria,1UKQ2@1239|Firmicutes,4H9CB@909932|Negativicutes	909932|Negativicutes	S	cluster protein-associated redox disulfide domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF1858
HKD2_k127_9376687_8	649764.HMPREF0762_00119	2.548e-32	132.0	COG1302@1|root,COG1302@2|Bacteria,2HV9W@201174|Actinobacteria,4CWIY@84998|Coriobacteriia	84998|Coriobacteriia	S	Asp23 family, cell envelope-related function	-	-	-	-	-	-	-	-	-	-	-	-	Asp23
HKD2_k127_9376687_1	1034345.CAEM01000023_gene800	1.633e-153	505.0	COG1461@1|root,COG1461@2|Bacteria,2GKII@201174|Actinobacteria,4CUVH@84998|Coriobacteriia	84998|Coriobacteriia	S	DAK2 domain fusion protein YloV	-	-	-	ko:K07030	-	-	-	-	ko00000	-	-	-	Dak1_2,Dak2
HKD2_k127_9376687_3	1121087.AUCK01000001_gene2648	4.966e-55	206.0	COG1307@1|root,COG1307@2|Bacteria,1TQDI@1239|Firmicutes,4HF8Z@91061|Bacilli,1ZRGY@1386|Bacillus	91061|Bacilli	S	Uncharacterised protein, DegV family COG1307	-	-	-	-	-	-	-	-	-	-	-	-	DegV
HKD2_k127_9376687_0	1504822.CCNO01000015_gene714	1.386e-195	631.0	COG1200@1|root,COG1200@2|Bacteria,2NNS3@2323|unclassified Bacteria	2|Bacteria	L	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)	recG	GO:0003674,GO:0003678,GO:0003724,GO:0003824,GO:0004003,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0008186,GO:0009314,GO:0009379,GO:0009628,GO:0009987,GO:0010501,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051276,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:0140098,GO:1901360,GO:1902494	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge
HKD2_k127_9376687_7	438753.AZC_2391	7.494e-35	142.0	COG0742@1|root,COG0742@2|Bacteria,1MXKW@1224|Proteobacteria,2U70Y@28211|Alphaproteobacteria,3EZ9I@335928|Xanthobacteraceae	28211|Alphaproteobacteria	L	Conserved hypothetical protein 95	rsmD	-	2.1.1.171	ko:K08316	-	-	R07234	RC00003	ko00000,ko01000,ko03009	-	-	-	Cons_hypoth95
HKD2_k127_9376687_5	479437.Elen_1356	2.787e-52	189.0	COG0669@1|root,COG0669@2|Bacteria,2GN1S@201174|Actinobacteria,4CVRP@84998|Coriobacteriia	84998|Coriobacteriia	H	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate	coaD	-	2.7.7.3	ko:K00954	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
HKD2_k127_9376687_6	469383.Cwoe_3698	3.238e-43	162.0	COG0711@1|root,COG0711@2|Bacteria,2HNZ4@201174|Actinobacteria,4CQ8B@84995|Rubrobacteria	84995|Rubrobacteria	C	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9376687_9	1235794.C811_00327	9.765e-27	117.0	COG1399@1|root,COG1399@2|Bacteria,2GJTS@201174|Actinobacteria,4CW3R@84998|Coriobacteriia	84998|Coriobacteriia	S	acr, cog1399	-	-	-	ko:K07040	-	-	-	-	ko00000	-	-	-	DUF177
HKD2_k127_9376687_12	1385935.N836_11085	1.187e-15	86.0	COG0454@1|root,COG0456@2|Bacteria,1G58K@1117|Cyanobacteria,1HGPV@1150|Oscillatoriales	1117|Cyanobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	ko:K03830	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_10
HKD2_k127_9376687_11	234267.Acid_6759	1.168e-15	80.0	COG0333@1|root,COG0333@2|Bacteria,3Y5HY@57723|Acidobacteria	57723|Acidobacteria	J	Belongs to the bacterial ribosomal protein bL32 family	rpmF	-	-	ko:K02911	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_L32p
HKD2_k127_9376687_2	351160.RCIX831	1.256e-89	307.0	COG1042@1|root,arCOG01340@2157|Archaea,2XT9G@28890|Euryarchaeota,2N9F3@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM CoA-binding domain protein	acdAB	-	6.2.1.13	ko:K01905,ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
HKD2_k127_9441451_1	1499967.BAYZ01000074_gene2145	1.843e-125	422.0	COG0235@1|root,COG0235@2|Bacteria	2|Bacteria	G	Class ii aldolase	-	-	2.2.1.8,4.1.2.17	ko:K01628,ko:K18847	ko00051,ko01120,map00051,map01120	-	R02262	RC00603,RC00604	ko00000,ko00001,ko01000	-	-	-	Aldolase_II
HKD2_k127_9441451_0	1499967.BAYZ01000074_gene2146	1.625e-156	514.0	COG2414@1|root,COG2414@2|Bacteria,2NP2Q@2323|unclassified Bacteria	2|Bacteria	C	Aldehyde ferredoxin oxidoreductase, N-terminal domain	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
HKD2_k127_9606823_13	580340.Tlie_1250	2.219e-06	50.0	COG0480@1|root,COG0480@2|Bacteria,3TA2B@508458|Synergistetes	508458|Synergistetes	J	elongation factor G	-	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
HKD2_k127_9606823_9	1122223.KB890696_gene416	7.846e-27	119.0	COG2755@1|root,COG2755@2|Bacteria,1WN2E@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	GDSL-like Lipase/Acylhydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
HKD2_k127_9606823_4	1504822.CCNO01000013_gene325	9.682e-50	191.0	COG1597@1|root,COG1597@2|Bacteria,2NS0F@2323|unclassified Bacteria	2|Bacteria	I	Diacylglycerol kinase catalytic domain	bmrU	-	2.7.1.107	ko:K07029	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	-	R02240	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	DAGK_cat
HKD2_k127_9606823_10	649764.HMPREF0762_00045	1.804e-20	106.0	COG0344@1|root,COG0344@2|Bacteria,2IF8Y@201174|Actinobacteria,4CVVI@84998|Coriobacteriia	84998|Coriobacteriia	I	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP	plsY	-	2.3.1.15	ko:K08591	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	G3P_acyltransf
HKD2_k127_9606823_12	589924.Ferp_1544	9.005e-17	81.0	COG1146@1|root,arCOG00959@2157|Archaea,2XZV5@28890|Euryarchaeota,246G0@183980|Archaeoglobi	183980|Archaeoglobi	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
HKD2_k127_9606823_5	1210884.HG799462_gene8507	3.152e-45	187.0	2C7TA@1|root,2Z9TR@2|Bacteria,2IXIJ@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9606823_2	886293.Sinac_1573	1.215e-56	209.0	COG2120@1|root,COG2120@2|Bacteria,2IZ0B@203682|Planctomycetes	203682|Planctomycetes	S	GlcNAc-PI de-N-acetylase	-	-	-	ko:K01463	-	-	-	-	ko00000,ko01000	-	-	-	PIG-L
HKD2_k127_9606823_3	756272.Plabr_3528	1.541e-54	207.0	COG1215@1|root,COG1215@2|Bacteria,2IZ02@203682|Planctomycetes	203682|Planctomycetes	M	Involved in cell wall	-	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2
HKD2_k127_9606823_8	289376.THEYE_A1018	8.956e-32	130.0	COG1765@1|root,COG1765@2|Bacteria	2|Bacteria	O	OsmC-like protein	-	-	-	ko:K07397	-	-	-	-	ko00000	-	-	-	OsmC
HKD2_k127_9606823_1	266117.Rxyl_1165	4.29e-123	416.0	COG2805@1|root,COG2805@2|Bacteria,2I9GT@201174|Actinobacteria,4CPG2@84995|Rubrobacteria	84995|Rubrobacteria	NU	Type II/IV secretion system protein	-	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
HKD2_k127_9606823_0	1121866.AUGK01000011_gene546	1.171e-125	416.0	COG2265@1|root,COG2265@2|Bacteria,2GIR3@201174|Actinobacteria,4CUDT@84998|Coriobacteriia	84998|Coriobacteriia	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family	rumA	-	2.1.1.190	ko:K03215	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TRAM,tRNA_U5-meth_tr
HKD2_k127_9606823_11	269797.Mbar_A0260	2.081e-17	87.0	COG4892@1|root,arCOG02922@2157|Archaea,2Y64K@28890|Euryarchaeota,2NBAN@224756|Methanomicrobia	2157|Archaea	S	Cytochrome b5-like Heme/Steroid binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Cyt-b5
HKD2_k127_9606823_7	1485545.JQLW01000007_gene789	7.512e-32	134.0	COG0664@1|root,COG0664@2|Bacteria,1MXID@1224|Proteobacteria	1224|Proteobacteria	K	COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases	-	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
HKD2_k127_9606823_6	477974.Daud_0172	1.293e-42	166.0	COG1011@1|root,COG1011@2|Bacteria,1UIE8@1239|Firmicutes,24I5V@186801|Clostridia,262HP@186807|Peptococcaceae	186801|Clostridia	S	Haloacid dehalogenase-like hydrolase	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2
HKD2_k127_9673158_3	477974.Daud_1374	1.173e-131	447.0	COG0826@1|root,COG0826@2|Bacteria,1TQS1@1239|Firmicutes,24909@186801|Clostridia,260G6@186807|Peptococcaceae	186801|Clostridia	O	PFAM peptidase U32	ydcP	-	-	ko:K08303	ko05120,map05120	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	DUF3656,Peptidase_U32
HKD2_k127_9673158_2	1111121.HMPREF1247_1573	8.431e-141	473.0	COG0744@1|root,COG0744@2|Bacteria,2GK21@201174|Actinobacteria,4CUT9@84998|Coriobacteriia	84998|Coriobacteriia	M	penicillin-binding protein, 1A family	-	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	PASTA,Transgly,Transpeptidase
HKD2_k127_9673158_6	868595.Desca_1211	2.169e-97	329.0	COG0327@1|root,COG0327@2|Bacteria,1UK7Y@1239|Firmicutes,248IP@186801|Clostridia,260W5@186807|Peptococcaceae	186801|Clostridia	S	PFAM NIF3 (NGG1p interacting factor 3)	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9673158_10	868595.Desca_1210	6.042e-43	167.0	COG2094@1|root,COG2094@2|Bacteria,1V1E6@1239|Firmicutes,24FRV@186801|Clostridia,261K2@186807|Peptococcaceae	186801|Clostridia	L	Belongs to the DNA glycosylase MPG family	-	-	3.2.2.21	ko:K03652	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Pur_DNA_glyco
HKD2_k127_9673158_1	479437.Elen_2338	1.594e-168	544.0	COG0165@1|root,COG0165@2|Bacteria,2GJ2A@201174|Actinobacteria,4CUGF@84998|Coriobacteriia	84998|Coriobacteriia	E	Argininosuccinate lyase C-terminal	argH	-	4.3.2.1	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01086	RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ASL_C2,Lyase_1
HKD2_k127_9673158_0	479437.Elen_2339	2.028e-183	589.0	COG0137@1|root,COG0137@2|Bacteria,2GK96@201174|Actinobacteria,4CV0T@84998|Coriobacteriia	84998|Coriobacteriia	E	Belongs to the argininosuccinate synthase family. Type 1 subfamily	argG	-	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Arginosuc_synth
HKD2_k127_9673158_9	1118060.CAGZ01000016_gene1807	1.211e-43	163.0	COG1438@1|root,COG1438@2|Bacteria,2GKA5@201174|Actinobacteria,4CVTV@84998|Coriobacteriia	84998|Coriobacteriia	K	Regulates arginine biosynthesis genes	argR	-	-	ko:K03402	-	-	-	-	ko00000,ko03000	-	-	-	Arg_repressor,Arg_repressor_C
HKD2_k127_9673158_7	696369.KI912183_gene2484	3.577e-92	312.0	COG0078@1|root,COG0078@2|Bacteria,1TPF2@1239|Firmicutes,248I5@186801|Clostridia,2608G@186807|Peptococcaceae	186801|Clostridia	E	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline	argF	-	2.1.3.3,2.1.3.6,2.1.3.9	ko:K00611,ko:K09065,ko:K13252	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01398,R07245	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS12430	OTCace,OTCace_N
HKD2_k127_9673158_4	1303518.CCALI_02163	1.888e-119	404.0	COG4992@1|root,COG4992@2|Bacteria	2|Bacteria	E	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity	argD	GO:0003674,GO:0005488,GO:0005515,GO:0008144,GO:0019842,GO:0030170,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363	2.6.1.11,2.6.1.17	ko:K00821	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	iAF987.Gmet_0204,iHN637.CLJU_RS10560	Aminotran_3
HKD2_k127_9673158_5	1121866.AUGK01000019_gene765	5.263e-99	332.0	COG0548@1|root,COG0548@2|Bacteria,2GKDS@201174|Actinobacteria,4CUQV@84998|Coriobacteriia	84998|Coriobacteriia	E	Belongs to the acetylglutamate kinase family. ArgB subfamily	argB	-	2.7.2.8	ko:K00930	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R02649	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase
HKD2_k127_9673158_8	292459.STH2890	1.968e-73	254.0	COG1364@1|root,COG1364@2|Bacteria,1TPBP@1239|Firmicutes,2497Q@186801|Clostridia	186801|Clostridia	E	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate	argJ	-	2.3.1.1,2.3.1.35	ko:K00620	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259,R02282	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	ArgJ
HKD2_k127_9806303_5	446462.Amir_6675	2.267e-12	73.0	COG1005@1|root,COG1005@2|Bacteria,2GIVY@201174|Actinobacteria,4DYNI@85010|Pseudonocardiales	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	nuoH	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
HKD2_k127_9806303_6	86416.Clopa_2012	1.43e-05	51.0	COG0713@1|root,COG0713@2|Bacteria,1V9Z8@1239|Firmicutes,24NKG@186801|Clostridia,36K3T@31979|Clostridiaceae	186801|Clostridia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoK	-	1.6.5.3	ko:K00340,ko:K05576	ko00190,ko01100,map00190,map01100	M00144,M00145	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q2
HKD2_k127_9806303_4	1379698.RBG1_1C00001G1062	3.584e-15	88.0	COG1007@1|root,COG1007@2|Bacteria,2NNMY@2323|unclassified Bacteria	2|Bacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoN-1	-	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
HKD2_k127_9806303_3	521003.COLINT_03749	2.421e-49	180.0	COG1576@1|root,COG1576@2|Bacteria,2IJE0@201174|Actinobacteria,4CVNM@84998|Coriobacteriia	84998|Coriobacteriia	J	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA	rlmH	-	2.1.1.177	ko:K00783	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SPOUT_MTase
HKD2_k127_9806303_2	1396418.BATQ01000007_gene1447	2.55e-70	258.0	2DR4U@1|root,33A62@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	CreD
HKD2_k127_9806303_0	1235794.C811_00279	3.562e-185	602.0	COG0018@1|root,COG0018@2|Bacteria,2GKQ3@201174|Actinobacteria,4CUI3@84998|Coriobacteriia	84998|Coriobacteriia	J	Arginyl-tRNA synthetase	argS	-	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
HKD2_k127_9806303_1	479437.Elen_0279	2.847e-109	364.0	COG0019@1|root,COG0019@2|Bacteria,2GKAI@201174|Actinobacteria,4CV4B@84998|Coriobacteriia	84998|Coriobacteriia	E	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine	lysA	-	4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
## 1383 queries scanned
## Total time (seconds): 157.80986642837524
## Rate: 8.76 q/s