## Fri Nov 15 06:34:06 2024
## emapper-2.1.12
## /data/home/zkh/miniconda3/envs/eggnog-mapper/bin/emapper.py -i /data/home/zkh/binning/bin_4635/bin/bin9/HKD_2_bin.70.fa -m mmseqs --itype genome -o HKD_2_bin.70 --output_dir /data/home/zkh/meta_analysis/eggnog-mapper/4635/HKD_2_bin.70 --cpu 28
##
#query	seed_ortholog	evalue	score	eggNOG_OGs	max_annot_lvl	COG_category	Description	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	PFAMs
HKD2_k127_10011664_1	1146883.BLASA_4981	2.072e-13	74.0	COG1487@1|root,COG1487@2|Bacteria,2IGMY@201174|Actinobacteria,4EVP0@85013|Frankiales	201174|Actinobacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	vapC	-	-	-	-	-	-	-	-	-	-	-	PIN
HKD2_k127_10011664_0	1123024.AUII01000008_gene1857	7.21e-26	108.0	COG4118@1|root,COG4118@2|Bacteria,2GSBB@201174|Actinobacteria	201174|Actinobacteria	D	Antitoxin component of a toxin-antitoxin (TA) module	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
HKD2_k127_10011664_2	8469.XP_007065456.1	1.459e-05	53.0	KOG1565@1|root,KOG1565@2759|Eukaryota,38CRR@33154|Opisthokonta,3B9IY@33208|Metazoa,3CT1E@33213|Bilateria,47ZW6@7711|Chordata,491AQ@7742|Vertebrata,4CKAC@8459|Testudines	33208|Metazoa	OW	Domain of unknown function (DUF3377)	MMP14	GO:0000003,GO:0000902,GO:0000904,GO:0001501,GO:0001503,GO:0001525,GO:0001541,GO:0001558,GO:0001568,GO:0001666,GO:0001704,GO:0001706,GO:0001763,GO:0001838,GO:0001935,GO:0001944,GO:0001952,GO:0001953,GO:0001958,GO:0002009,GO:0002165,GO:0002218,GO:0002253,GO:0002376,GO:0002682,GO:0002684,GO:0002685,GO:0002687,GO:0002694,GO:0002696,GO:0003006,GO:0003007,GO:0003143,GO:0003144,GO:0003313,GO:0003314,GO:0003315,GO:0003318,GO:0003319,GO:0003674,GO:0003824,GO:0004175,GO:0004177,GO:0004222,GO:0004252,GO:0005102,GO:0005178,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005615,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005768,GO:0005794,GO:0005796,GO:0005829,GO:0005856,GO:0005886,GO:0005887,GO:0006508,GO:0006807,GO:0006928,GO:0006929,GO:0006935,GO:0006950,GO:0006979,GO:0007154,GO:0007162,GO:0007267,GO:0007275,GO:0007276,GO:0007292,GO:0007369,GO:0007399,GO:0007409,GO:0007411,GO:0007413,GO:0007417,GO:0007419,GO:0007424,GO:0007426,GO:0007444,GO:0007492,GO:0007503,GO:0007505,GO:0007507,GO:0007548,GO:0007552,GO:0007560,GO:0007561,GO:0008037,GO:0008038,GO:0008045,GO:0008047,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008236,GO:0008237,GO:0008238,GO:0008270,GO:0008283,GO:0008285,GO:0008347,GO:0008406,GO:0008584,GO:0008585,GO:0008593,GO:0009056,GO:0009605,GO:0009611,GO:0009612,GO:0009628,GO:0009653,GO:0009719,GO:0009725,GO:0009790,GO:0009791,GO:0009792,GO:0009886,GO:0009887,GO:0009888,GO:0009893,GO:0009897,GO:0009966,GO:0009968,GO:0009986,GO:0009987,GO:0010033,GO:0010467,GO:0010468,GO:0010604,GO:0010628,GO:0010646,GO:0010648,GO:0010810,GO:0010812,GO:0010830,GO:0010831,GO:0010952,GO:0010954,GO:0012505,GO:0014070,GO:0016020,GO:0016021,GO:0016043,GO:0016331,GO:0016477,GO:0016485,GO:0016504,GO:0016787,GO:0017171,GO:0019222,GO:0019538,GO:0019953,GO:0022008,GO:0022411,GO:0022414,GO:0022617,GO:0023051,GO:0023052,GO:0023057,GO:0030030,GO:0030111,GO:0030154,GO:0030155,GO:0030162,GO:0030178,GO:0030182,GO:0030198,GO:0030234,GO:0030307,GO:0030323,GO:0030324,GO:0030334,GO:0030335,GO:0030425,GO:0030574,GO:0030728,GO:0031175,GO:0031224,GO:0031226,GO:0031323,GO:0031325,GO:0031347,GO:0031349,GO:0031410,GO:0031638,GO:0031974,GO:0031982,GO:0032268,GO:0032270,GO:0032501,GO:0032502,GO:0032504,GO:0032879,GO:0032963,GO:0032989,GO:0032990,GO:0034330,GO:0034769,GO:0035050,GO:0035148,GO:0035202,GO:0035239,GO:0035295,GO:0035987,GO:0035988,GO:0036075,GO:0036293,GO:0036477,GO:0040008,GO:0040011,GO:0040012,GO:0040017,GO:0040036,GO:0040037,GO:0042060,GO:0042063,GO:0042127,GO:0042221,GO:0042330,GO:0042470,GO:0042995,GO:0043005,GO:0043009,GO:0043062,GO:0043085,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043615,GO:0043627,GO:0044087,GO:0044093,GO:0044238,GO:0044352,GO:0044354,GO:0044421,GO:0044422,GO:0044424,GO:0044425,GO:0044431,GO:0044444,GO:0044446,GO:0044459,GO:0044463,GO:0044464,GO:0044703,GO:0044877,GO:0045088,GO:0045089,GO:0045111,GO:0045137,GO:0045165,GO:0045168,GO:0045216,GO:0045577,GO:0045579,GO:0045595,GO:0045597,GO:0045619,GO:0045621,GO:0045746,GO:0045862,GO:0045927,GO:0046331,GO:0046528,GO:0046529,GO:0046545,GO:0046546,GO:0046660,GO:0046661,GO:0046872,GO:0046914,GO:0048468,GO:0048513,GO:0048514,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048562,GO:0048563,GO:0048568,GO:0048569,GO:0048583,GO:0048584,GO:0048585,GO:0048598,GO:0048608,GO:0048609,GO:0048646,GO:0048666,GO:0048667,GO:0048699,GO:0048701,GO:0048704,GO:0048705,GO:0048706,GO:0048707,GO:0048729,GO:0048731,GO:0048754,GO:0048770,GO:0048771,GO:0048812,GO:0048856,GO:0048858,GO:0048869,GO:0048870,GO:0050673,GO:0050776,GO:0050778,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0050839,GO:0050864,GO:0050865,GO:0050867,GO:0050871,GO:0050896,GO:0051094,GO:0051128,GO:0051129,GO:0051147,GO:0051149,GO:0051153,GO:0051155,GO:0051171,GO:0051173,GO:0051179,GO:0051239,GO:0051240,GO:0051246,GO:0051247,GO:0051249,GO:0051251,GO:0051270,GO:0051272,GO:0051336,GO:0051345,GO:0051604,GO:0051674,GO:0051704,GO:0051893,GO:0051895,GO:0052547,GO:0060255,GO:0060322,GO:0060348,GO:0060349,GO:0060350,GO:0060429,GO:0060541,GO:0060562,GO:0060612,GO:0060828,GO:0060973,GO:0061134,GO:0061138,GO:0061448,GO:0061458,GO:0061564,GO:0065007,GO:0065009,GO:0070006,GO:0070011,GO:0070013,GO:0070482,GO:0070613,GO:0071704,GO:0071711,GO:0071840,GO:0071944,GO:0072091,GO:0072175,GO:0072358,GO:0072359,GO:0080090,GO:0080134,GO:0090090,GO:0090109,GO:0090287,GO:0090288,GO:0097094,GO:0097156,GO:0097447,GO:0097458,GO:0097485,GO:0097708,GO:0098552,GO:0098772,GO:0106030,GO:0120025,GO:0120036,GO:0120038,GO:0120039,GO:0140096,GO:1901201,GO:1901202,GO:1901564,GO:1901888,GO:1901889,GO:1902105,GO:1902107,GO:1903053,GO:1903054,GO:1903317,GO:1903319,GO:1903391,GO:1903392,GO:1903706,GO:1903708,GO:1904888,GO:1905521,GO:1905523,GO:1990834,GO:2000026,GO:2000145,GO:2000147,GO:2000647	3.4.24.80	ko:K07763,ko:K07995,ko:K07996,ko:K07997,ko:K08002,ko:K08003	ko04668,ko04912,ko05206,map04668,map04912,map05206	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	DUF3377,Hemopexin,PG_binding_1,Peptidase_M10
HKD2_k127_10082851_2	298654.FraEuI1c_1816	5.117e-94	321.0	COG1647@1|root,COG1647@2|Bacteria,2GM1Y@201174|Actinobacteria,4ETTX@85013|Frankiales	201174|Actinobacteria	S	Serine aminopeptidase, S33	yvaK	-	3.1.1.1	ko:K03928	-	-	-	-	ko00000,ko01000	-	-	-	Hydrolase_4
HKD2_k127_10082851_7	479432.Sros_4254	2.286e-24	119.0	COG3467@1|root,COG3467@2|Bacteria,2IQ9Y@201174|Actinobacteria,4EJNW@85012|Streptosporangiales	201174|Actinobacteria	S	Pyridoxamine 5'-phosphate oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Pyridox_ox_2
HKD2_k127_10082851_12	365528.KB891208_gene2811	5.71e-07	61.0	COG1366@1|root,COG1366@2|Bacteria	2|Bacteria	T	antisigma factor binding	-	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE,STAS_2
HKD2_k127_10082851_5	1122138.AQUZ01000031_gene4209	1.809e-45	173.0	2CM5B@1|root,32SDR@2|Bacteria,2GUKY@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_10082851_1	44454.NF84_13895	5.602e-150	503.0	COG4948@1|root,COG4948@2|Bacteria,2GKSK@201174|Actinobacteria,2381D@1762|Mycobacteriaceae	201174|Actinobacteria	M	Mandelate racemase muconate lactonizing enzyme	-	-	-	-	-	-	-	-	-	-	-	-	MR_MLE_C,MR_MLE_N
HKD2_k127_10082851_0	35754.JNYJ01000072_gene2528	8.025e-294	912.0	COG0028@1|root,COG0028@2|Bacteria,2GJ20@201174|Actinobacteria,4D9PN@85008|Micromonosporales	201174|Actinobacteria	EH	Belongs to the TPP enzyme family	-	-	1.2.3.3,1.2.5.1	ko:K00156,ko:K00158	ko00620,ko01100,map00620,map01100	-	R00207,R03145	RC00860,RC02745	ko00000,ko00001,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
HKD2_k127_10082851_10	479431.Namu_4465	4.429e-16	87.0	2DEXX@1|root,2ZPQ4@2|Bacteria,2HDEY@201174|Actinobacteria,4EWYK@85013|Frankiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_10082851_9	525909.Afer_1653	2.056e-19	93.0	2984K@1|root,2ZVAJ@2|Bacteria,2GY3U@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_10082851_13	656024.FsymDg_3406	5.492e-06	49.0	COG2337@1|root,COG2337@2|Bacteria,2HKW6@201174|Actinobacteria,4EWMI@85013|Frankiales	201174|Actinobacteria	L	Toxic component of a toxin-antitoxin (TA) module	-	-	-	ko:K07171	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PemK_toxin
HKD2_k127_10082851_4	656024.FsymDg_3406	1.944e-54	193.0	COG2337@1|root,COG2337@2|Bacteria,2HKW6@201174|Actinobacteria,4EWMI@85013|Frankiales	201174|Actinobacteria	L	Toxic component of a toxin-antitoxin (TA) module	-	-	-	ko:K07171	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PemK_toxin
HKD2_k127_10082851_3	66377.JOBH01000012_gene4396	1.172e-83	292.0	COG0707@1|root,COG0707@2|Bacteria,2GREI@201174|Actinobacteria	201174|Actinobacteria	M	Monogalactosyldiacylglycerol (MGDG) synthase	-	-	2.4.1.315	ko:K03429	ko00561,ko01100,map00561,map01100	-	R02689,R04377	RC00005,RC00059	ko00000,ko00001,ko01000,ko01003	-	GT28	-	MGDG_synth
HKD2_k127_10082851_8	685727.REQ_24250	8.383e-24	109.0	COG0697@1|root,COG0697@2|Bacteria,2GRXH@201174|Actinobacteria,4FX24@85025|Nocardiaceae	201174|Actinobacteria	EG	Permeases of the drug metabolite transporter (DMT) superfamily	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_10112004_1	1380393.JHVP01000003_gene1247	1.532e-74	256.0	COG1063@1|root,COG1063@2|Bacteria,2GKC7@201174|Actinobacteria,4EU93@85013|Frankiales	201174|Actinobacteria	C	PFAM Alcohol dehydrogenase GroES domain protein	-	-	1.1.1.14	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014	R00875,R01896	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
HKD2_k127_10112004_0	1068978.AMETH_0829	3.492e-153	490.0	COG1063@1|root,COG1063@2|Bacteria,2GKC7@201174|Actinobacteria,4DXRH@85010|Pseudonocardiales	201174|Actinobacteria	E	PFAM Alcohol dehydrogenase GroES-like domain	-	-	1.1.1.1,1.6.5.5	ko:K00001,ko:K00344	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
HKD2_k127_10131791_2	1123024.AUII01000039_gene1421	2.078e-96	319.0	COG1595@1|root,COG1595@2|Bacteria,2GMRK@201174|Actinobacteria,4E15V@85010|Pseudonocardiales	201174|Actinobacteria	K	Sigma-70 region 2	sigG	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	NTF2,Sigma70_r2,Sigma70_r4_2,SnoaL_2
HKD2_k127_10131791_6	67281.JNZZ01000023_gene3993	1.756e-12	72.0	2B42Y@1|root,31WTH@2|Bacteria,2INUX@201174|Actinobacteria,41BG0@629295|Streptomyces griseus group	201174|Actinobacteria	S	STAS domain	-	-	-	-	-	-	-	-	-	-	-	-	STAS_2
HKD2_k127_10131791_3	882083.SacmaDRAFT_3403	4.494e-91	304.0	COG1396@1|root,COG1396@2|Bacteria,2GXAS@201174|Actinobacteria,4E2KY@85010|Pseudonocardiales	201174|Actinobacteria	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2,HTH_3
HKD2_k127_10131791_1	471857.Svir_15010	8.294e-101	333.0	COG1296@1|root,COG1296@2|Bacteria,2GN6R@201174|Actinobacteria,4E35S@85010|Pseudonocardiales	201174|Actinobacteria	E	Branched-chain amino acid permease	-	-	-	-	-	-	-	-	-	-	-	-	AzlC
HKD2_k127_10131791_5	1137271.AZUM01000001_gene586	3.465e-25	121.0	2DMQN@1|root,32T1U@2|Bacteria,2GS5T@201174|Actinobacteria,4E6JM@85010|Pseudonocardiales	201174|Actinobacteria	S	PFAM Branched-chain amino acid transport protein (AzlD)	-	-	-	-	-	-	-	-	-	-	-	-	AzlD
HKD2_k127_10131791_4	1206733.BAGC01000112_gene6859	1.694e-30	126.0	COG1846@1|root,COG1846@2|Bacteria,2IHTK@201174|Actinobacteria,4G1IP@85025|Nocardiaceae	201174|Actinobacteria	K	MarR family	-	-	-	-	-	-	-	-	-	-	-	-	MarR_2
HKD2_k127_10131791_0	645465.ACUR01000707_gene2555	4.146e-118	394.0	COG0477@1|root,COG0477@2|Bacteria,2GKUK@201174|Actinobacteria	201174|Actinobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD2_k127_10148693_1	656024.FsymDg_0507	6.528e-98	331.0	COG1131@1|root,COG1131@2|Bacteria,2GIY8@201174|Actinobacteria,4ERP0@85013|Frankiales	201174|Actinobacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990,ko:K09695	ko02010,map02010	M00252,M00254	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.102	-	-	ABC_tran
HKD2_k127_10148693_3	1229780.BN381_100110	3.749e-10	65.0	COG2161@1|root,COG2161@2|Bacteria,2GT6V@201174|Actinobacteria	201174|Actinobacteria	D	Antitoxin Phd_YefM, type II toxin-antitoxin system	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
HKD2_k127_10148693_0	266117.Rxyl_1110	5.422e-161	524.0	COG0281@1|root,COG0281@2|Bacteria,2GJAJ@201174|Actinobacteria,4CPBI@84995|Rubrobacteria	84995|Rubrobacteria	C	Malic enzyme, NAD binding domain	-	-	1.1.1.38	ko:K00027	ko00620,ko01200,ko02020,map00620,map01200,map02020	-	R00214	RC00105	ko00000,ko00001,ko01000	-	-	-	ACT_4,Malic_M,malic
HKD2_k127_10148693_2	1123023.JIAI01000008_gene1486	1.321e-10	67.0	COG1848@1|root,COG1848@2|Bacteria,2IJ89@201174|Actinobacteria,4EBUF@85010|Pseudonocardiales	201174|Actinobacteria	S	PIN domain	-	GO:0005575,GO:0005576	-	ko:K07064	-	-	-	-	ko00000	-	-	-	PIN
HKD2_k127_10148693_4	1299327.I546_6182	3.032e-09	63.0	2DSMH@1|root,33GPM@2|Bacteria,2GR8G@201174|Actinobacteria,23BKG@1762|Mycobacteriaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_10209158_1	1003195.SCAT_1501	6.741e-137	446.0	COG1055@1|root,COG1055@2|Bacteria,2GMQJ@201174|Actinobacteria	201174|Actinobacteria	P	Arsenical pump membrane protein	arsB	-	-	ko:K03893	-	-	-	-	ko00000,ko02000	2.A.45.1,3.A.4.1	-	-	ArsB
HKD2_k127_10209158_3	1157638.KB892191_gene5170	7.244e-54	196.0	COG0589@1|root,COG0589@2|Bacteria,2IFKZ@201174|Actinobacteria	201174|Actinobacteria	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD2_k127_10209158_0	298653.Franean1_5074	4.933e-170	554.0	COG0328@1|root,COG0406@1|root,COG0328@2|Bacteria,COG0406@2|Bacteria,2GJ9R@201174|Actinobacteria,4ERXW@85013|Frankiales	201174|Actinobacteria	GL	phosphoglycerate mutase	rnhA	GO:0003674,GO:0003676,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005488,GO:0006139,GO:0006401,GO:0006725,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016070,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016891,GO:0016893,GO:0017144,GO:0018130,GO:0019438,GO:0019439,GO:0032296,GO:0033013,GO:0033014,GO:0034641,GO:0034655,GO:0042364,GO:0042578,GO:0043170,GO:0043755,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0046700,GO:0051186,GO:0051188,GO:0071667,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901575,GO:1901576	3.1.26.4,3.1.3.73	ko:K02226,ko:K22316	ko00860,ko01100,ko03030,map00860,map01100,map03030	M00122	R04594,R11173	RC00017	ko00000,ko00001,ko00002,ko01000,ko03032	-	-	-	His_Phos_1,RVT_3
HKD2_k127_10209158_2	365528.KB891102_gene4392	1.189e-88	301.0	COG1579@1|root,COG1579@2|Bacteria,2GP84@201174|Actinobacteria,4ESKG@85013|Frankiales	201174|Actinobacteria	S	C4-type zinc ribbon domain	-	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	-	ko:K07164	-	-	-	-	ko00000	-	-	-	zf-RING_7
HKD2_k127_1104838_2	1463934.JOCF01000043_gene93	1.842e-28	121.0	COG2018@1|root,COG2018@2|Bacteria,2IIPN@201174|Actinobacteria	201174|Actinobacteria	S	distant relative of homeotic protein bithoraxoid	-	-	-	ko:K07131	-	-	-	-	ko00000	-	-	-	Robl_LC7
HKD2_k127_1104838_1	926569.ANT_06780	5.187e-37	148.0	COG2229@1|root,COG2229@2|Bacteria,2G8FZ@200795|Chloroflexi	200795|Chloroflexi	S	TIGRFAM small GTP-binding protein	-	-	-	ko:K06945	-	-	-	-	ko00000	-	-	-	ATP_bind_1
HKD2_k127_1104838_0	1869.MB27_19195	2.114e-42	170.0	2AID4@1|root,318UG@2|Bacteria,2GJ2X@201174|Actinobacteria,4DE9K@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1130526_2	326424.FRAAL3773	6.977e-70	239.0	COG0229@1|root,COG0229@2|Bacteria,2IHV0@201174|Actinobacteria,4ESRX@85013|Frankiales	201174|Actinobacteria	O	PFAM Methionine sulfoxide reductase B	msrB	-	1.8.4.12	ko:K07305	-	-	-	-	ko00000,ko01000	-	-	-	SelR
HKD2_k127_1130526_1	479433.Caci_7971	2.654e-186	600.0	COG4992@1|root,COG4992@2|Bacteria,2GK0J@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	rocD	-	2.6.1.13	ko:K00819	ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130	-	R00667	RC00006,RC00062	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_3
HKD2_k127_1130526_0	656024.FsymDg_4476	0.0	1151.0	COG0457@1|root,COG2114@1|root,COG3899@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG3899@2|Bacteria,2GJRI@201174|Actinobacteria,4ETX1@85013|Frankiales	201174|Actinobacteria	T	PFAM Adenylyl cyclase class-3 4 guanylyl cyclase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,DZR,Guanylate_cyc,TPR_12
HKD2_k127_1133566_7	1171373.PACID_03410	0.0002356	43.0	COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,2IAHV@201174|Actinobacteria,4DUEP@85009|Propionibacteriales	201174|Actinobacteria	L	Winged helix-turn helix	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_28,HTH_32,HTH_33
HKD2_k127_1133566_6	909613.UO65_5025	9.011e-17	93.0	COG1141@1|root,COG1141@2|Bacteria,2GSJ7@201174|Actinobacteria,4E6Z9@85010|Pseudonocardiales	201174|Actinobacteria	C	4Fe-4S single cluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_15
HKD2_k127_1133566_5	909613.UO65_5026	1.678e-18	97.0	COG1894@1|root,COG1894@2|Bacteria,2GNN9@201174|Actinobacteria,4E6BU@85010|Pseudonocardiales	201174|Actinobacteria	C	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region	-	-	-	-	-	-	-	-	-	-	-	-	Complex1_51K,NADH_4Fe-4S,SLBB
HKD2_k127_1133566_0	1089544.KB912942_gene1565	2.1e-80	288.0	COG1894@1|root,COG1894@2|Bacteria,2GNN9@201174|Actinobacteria,4E6BU@85010|Pseudonocardiales	201174|Actinobacteria	C	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region	-	-	-	-	-	-	-	-	-	-	-	-	Complex1_51K,NADH_4Fe-4S,SLBB
HKD2_k127_1133566_1	543632.JOJL01000068_gene3301	2.57e-53	210.0	COG4097@1|root,COG4097@2|Bacteria,2GQH2@201174|Actinobacteria,4DD0S@85008|Micromonosporales	201174|Actinobacteria	P	nitric oxide dioxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	Ferric_reduct
HKD2_k127_1133566_3	1449353.JQMQ01000005_gene439	3.163e-40	163.0	COG1477@1|root,COG1477@2|Bacteria,2H74Y@201174|Actinobacteria,2NF9E@228398|Streptacidiphilus	201174|Actinobacteria	H	ApbE family	-	-	2.7.1.180	ko:K03734	-	-	-	-	ko00000,ko01000	-	-	-	ApbE
HKD2_k127_1133566_4	1463861.JNXE01000032_gene1455	3.623e-37	151.0	COG1477@1|root,COG1477@2|Bacteria,2H74Y@201174|Actinobacteria	201174|Actinobacteria	H	Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein	-	-	2.7.1.180	ko:K03734	-	-	-	-	ko00000,ko01000	-	-	-	ApbE
HKD2_k127_1133566_2	1336208.JADY01000010_gene3309	8.2e-42	155.0	COG0569@1|root,COG0569@2|Bacteria,1R7KM@1224|Proteobacteria,2TY5D@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	COG0569 K transport systems, NAD-binding component	-	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
HKD2_k127_1143328_4	526225.Gobs_3532	5.157e-17	80.0	COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,2GJQI@201174|Actinobacteria,4ERUS@85013|Frankiales	201174|Actinobacteria	L	manually curated	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_28,HTH_29,HTH_32
HKD2_k127_1143328_2	656024.FsymDg_1289	3.33e-61	215.0	COG0582@1|root,COG0582@2|Bacteria,2GJ2M@201174|Actinobacteria	201174|Actinobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
HKD2_k127_1143328_6	106370.Francci3_0910	1.612e-06	51.0	COG1961@1|root,COG1961@2|Bacteria,2I8HV@201174|Actinobacteria,4EUGR@85013|Frankiales	201174|Actinobacteria	L	Resolvase, N terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
HKD2_k127_1143328_1	656024.FsymDg_1291	6.903e-71	246.0	COG1225@1|root,COG1225@2|Bacteria,2IHZ6@201174|Actinobacteria,4ESII@85013|Frankiales	201174|Actinobacteria	O	PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	bcp	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
HKD2_k127_1143328_3	1122939.ATUD01000001_gene51	9.914e-51	203.0	COG0524@1|root,COG0524@2|Bacteria,2I04R@201174|Actinobacteria,4CQ0G@84995|Rubrobacteria	84995|Rubrobacteria	H	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway	rbsK	-	2.7.1.15	ko:K00852	ko00030,map00030	-	R01051,R02750	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
HKD2_k127_1143328_0	1206741.BAFX01000146_gene2855	5.59e-120	399.0	COG1397@1|root,COG1397@2|Bacteria,2GMYG@201174|Actinobacteria,4FV19@85025|Nocardiaceae	201174|Actinobacteria	O	ADP-ribosylglycohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	ADP_ribosyl_GH
HKD2_k127_1143328_5	1149133.ppKF707_2226	5.324e-09	64.0	COG0215@1|root,COG0215@2|Bacteria,1MV8H@1224|Proteobacteria,1RP5K@1236|Gammaproteobacteria,1YEDD@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iECUMN_1333.ECUMN_0566,iJN746.PP_2905	DALR_2,tRNA-synt_1e,tRNA-synt_1g
HKD2_k127_1206329_4	710111.FraQA3DRAFT_3717	2.758e-145	473.0	COG0438@1|root,COG0438@2|Bacteria,2GK9J@201174|Actinobacteria,4EX3T@85013|Frankiales	201174|Actinobacteria	M	Glycosyl transferase 4-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
HKD2_k127_1206329_1	106370.Francci3_0721	4.122e-232	732.0	COG0438@1|root,COG0438@2|Bacteria,2IJ4J@201174|Actinobacteria	201174|Actinobacteria	M	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
HKD2_k127_1206329_3	656024.FsymDg_1051	8.633e-191	630.0	COG1216@1|root,COG1216@2|Bacteria,2GK2D@201174|Actinobacteria,4ET5X@85013|Frankiales	201174|Actinobacteria	S	PFAM Glycosyl transferase family 2	-	-	-	ko:K07011	-	-	-	-	ko00000	-	-	-	Glyco_tranf_2_3,Glyco_trans_2_3,Glycos_transf_2
HKD2_k127_1206329_2	656024.FsymDg_1052	8.095e-194	626.0	COG1134@1|root,COG1134@2|Bacteria,2GIVF@201174|Actinobacteria,4EUCZ@85013|Frankiales	201174|Actinobacteria	GM	ABC transporter	rfbB2	-	3.6.3.40	ko:K01990,ko:K09691,ko:K09693	ko02010,map02010	M00250,M00251,M00254	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.103,3.A.1.104	-	-	ABC_tran,Wzt_C
HKD2_k127_1206329_5	656024.FsymDg_1053	2.54e-125	417.0	COG1682@1|root,COG1682@2|Bacteria,2GP5K@201174|Actinobacteria,4ESU0@85013|Frankiales	201174|Actinobacteria	GM	Transport permease protein	wzm	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
HKD2_k127_1206329_0	656024.FsymDg_1054	0.0	1129.0	COG5610@1|root,COG5610@2|Bacteria,2IBYY@201174|Actinobacteria	201174|Actinobacteria	S	Hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1206329_6	326424.FRAAL1241	8.837e-111	400.0	COG4122@1|root,COG4122@2|Bacteria,2IT06@201174|Actinobacteria	201174|Actinobacteria	S	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_24
HKD2_k127_1206329_7	436229.JOEH01000030_gene4767	7.978e-77	269.0	COG4346@1|root,COG4346@2|Bacteria	2|Bacteria	O	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	2.4.1.109	ko:K00728	ko00514,ko00515,ko01100,map00514,map00515,map01100	-	R04072,R07620,R11399	RC00005,RC00059,RC00397	ko00000,ko00001,ko01000,ko01003	-	GT39	-	GT87,PMT_2
HKD2_k127_1272405_1	526225.Gobs_3532	5.157e-17	80.0	COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,2GJQI@201174|Actinobacteria,4ERUS@85013|Frankiales	201174|Actinobacteria	L	manually curated	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_28,HTH_29,HTH_32
HKD2_k127_1272405_0	656024.FsymDg_0919	7.603e-302	941.0	COG0210@1|root,COG0210@2|Bacteria,2GKRW@201174|Actinobacteria,4ES82@85013|Frankiales	201174|Actinobacteria	L	PFAM UvrD REP helicase	uvrD2	GO:0000287,GO:0003674,GO:0003678,GO:0003824,GO:0004386,GO:0005488,GO:0006996,GO:0008094,GO:0008150,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0040007,GO:0042623,GO:0043167,GO:0043169,GO:0046872,GO:0051276,GO:0071103,GO:0071840,GO:0140097	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HRDC,UvrD-helicase,UvrD_C
HKD2_k127_1274092_0	1206741.BAFX01000118_gene7358	6.502e-96	337.0	COG0477@1|root,COG0477@2|Bacteria,2GIUM@201174|Actinobacteria,4FX8C@85025|Nocardiaceae	201174|Actinobacteria	EGP	Sugar (and other) transporter	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD2_k127_1274092_1	298653.Franean1_1812	4.892e-44	169.0	COG1290@1|root,COG1290@2|Bacteria,2GJ1E@201174|Actinobacteria,4ERM6@85013|Frankiales	201174|Actinobacteria	C	Cytochrome b	qcrB	-	-	ko:K03891	ko00190,ko01100,map00190,map01100	M00151	-	-	ko00000,ko00001,ko00002	-	-	-	Cytochrom_B_N_2
HKD2_k127_1274092_2	365528.KB891203_gene3438	6.967e-37	143.0	COG1290@1|root,COG1290@2|Bacteria,2GJ1E@201174|Actinobacteria,4ERM6@85013|Frankiales	201174|Actinobacteria	C	Cytochrome b	qcrB	-	-	ko:K03891	ko00190,ko01100,map00190,map01100	M00151	-	-	ko00000,ko00001,ko00002	-	-	-	Cytochrom_B_N_2
HKD2_k127_1320552_0	326424.FRAAL5122	1.298e-211	685.0	COG0843@1|root,COG0843@2|Bacteria,2GJHX@201174|Actinobacteria,4ES0K@85013|Frankiales	201174|Actinobacteria	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	ctaD	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0016021,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0034220,GO:0040007,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0051179,GO:0051234,GO:0055085,GO:0055114,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1902600	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
HKD2_k127_1320552_3	656024.FsymDg_3190	9.417e-112	404.0	COG1622@1|root,COG1622@2|Bacteria,2GNXA@201174|Actinobacteria,4ESMU@85013|Frankiales	201174|Actinobacteria	C	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)	ctaC	GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006119,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009319,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016310,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0034641,GO:0040007,GO:0042773,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044121,GO:0044237,GO:0044238,GO:0044281,GO:0044403,GO:0044419,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0046034,GO:0046483,GO:0051704,GO:0055086,GO:0055114,GO:0070069,GO:0071704,GO:0071944,GO:0072521,GO:0098796,GO:1901135,GO:1901360,GO:1901564,GO:1902494	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2,COX2_TM
HKD2_k127_1320552_2	656024.FsymDg_3194	1.651e-160	533.0	COG1104@1|root,COG1104@2|Bacteria,2GJ2B@201174|Actinobacteria,4EU9Z@85013|Frankiales	201174|Actinobacteria	E	PFAM aminotransferase class V	-	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5,TusA
HKD2_k127_1320552_6	43759.JNWK01000136_gene1700	3.949e-21	107.0	COG1104@1|root,COG1104@2|Bacteria,2GJ2B@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the sulfur carrier protein TusA family	-	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5,TusA
HKD2_k127_1320552_1	656024.FsymDg_3196	1.62e-162	517.0	COG0524@1|root,COG0524@2|Bacteria,2GKBG@201174|Actinobacteria,4ERNY@85013|Frankiales	201174|Actinobacteria	G	PFAM PfkB domain protein	adoK	GO:0000166,GO:0000287,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0004001,GO:0005488,GO:0005524,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0005975,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019200,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032549,GO:0032550,GO:0032552,GO:0032553,GO:0032554,GO:0032555,GO:0032559,GO:0032560,GO:0032561,GO:0032567,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046390,GO:0046483,GO:0046835,GO:0046872,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.7.1.20	ko:K00856	ko00230,ko01100,map00230,map01100	-	R00185	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
HKD2_k127_1320552_5	656024.FsymDg_3197	6.288e-55	198.0	COG0316@1|root,COG0316@2|Bacteria,2IHR0@201174|Actinobacteria,4ESRR@85013|Frankiales	201174|Actinobacteria	S	Belongs to the HesB IscA family	iscA	GO:0003674,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0016226,GO:0019538,GO:0022607,GO:0031163,GO:0043167,GO:0043169,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0048037,GO:0051186,GO:0051536,GO:0051537,GO:0051539,GO:0051540,GO:0051604,GO:0071704,GO:0071840,GO:0071944,GO:1901564	-	ko:K13628	-	-	-	-	ko00000,ko03016	-	-	-	Fe-S_biosyn
HKD2_k127_1320552_4	644283.Micau_4578	1.245e-107	360.0	COG1929@1|root,COG1929@2|Bacteria,2GKHX@201174|Actinobacteria,4D8WD@85008|Micromonosporales	201174|Actinobacteria	G	Belongs to the glycerate kinase type-1 family	glxK	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	2.7.1.165	ko:K00865	ko00260,ko00561,ko00630,ko01100,ko01120,ko01130,map00260,map00561,map00630,map01100,map01120,map01130	-	R08572	RC00002,RC00428	ko00000,ko00001,ko01000	-	-	-	Gly_kinase
HKD2_k127_133833_5	649831.L083_1004	1.063e-47	173.0	COG4214@1|root,COG4214@2|Bacteria,2GJAH@201174|Actinobacteria,4DB7Z@85008|Micromonosporales	201174|Actinobacteria	G	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K10544	ko02010,map02010	M00215	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.4	-	-	BPD_transp_2
HKD2_k127_133833_4	298654.FraEuI1c_7039	2.4e-97	338.0	COG1940@1|root,COG1940@2|Bacteria,2GPEI@201174|Actinobacteria,4EX83@85013|Frankiales	201174|Actinobacteria	GK	PFAM ROK family protein	-	-	-	-	-	-	-	-	-	-	-	-	ROK
HKD2_k127_133833_0	106370.Francci3_1326	0.0	1020.0	COG1154@1|root,COG1154@2|Bacteria,2GMFA@201174|Actinobacteria,4ES3F@85013|Frankiales	201174|Actinobacteria	H	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)	dxs	-	2.2.1.7	ko:K01662	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	M00096	R05636	RC00032	ko00000,ko00001,ko00002,ko01000	-	-	-	DXP_synthase_N,Transket_pyr,Transketolase_C
HKD2_k127_133833_1	1121946.AUAX01000028_gene5817	1.265e-196	625.0	COG0531@1|root,COG0531@2|Bacteria,2GJ75@201174|Actinobacteria,4D8KN@85008|Micromonosporales	201174|Actinobacteria	E	amino acid	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2,AA_permease_C
HKD2_k127_133833_3	710111.FraQA3DRAFT_2963	5.723e-99	332.0	COG0392@1|root,COG0392@2|Bacteria,2IC25@201174|Actinobacteria	201174|Actinobacteria	S	Lysylphosphatidylglycerol synthase TM region	-	-	-	ko:K07027,ko:K20468	-	-	-	-	ko00000,ko02000	4.D.2,4.D.2.4.1	-	-	LPG_synthase_TM
HKD2_k127_133833_2	479433.Caci_6776	3.937e-162	517.0	COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,2GJ50@201174|Actinobacteria	201174|Actinobacteria	I	3-hydroxyacyl-CoA dehydrogenase	fadB	-	1.1.1.35,4.2.1.17,5.1.2.3	ko:K01782	ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212	M00032,M00087	R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094	RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	3HCDH,3HCDH_N,ECH_1
HKD2_k127_1341217_14	269800.Tfu_1591	1.482e-30	136.0	2CK7X@1|root,345CK@2|Bacteria,2IH14@201174|Actinobacteria	201174|Actinobacteria	S	CRISPR-associated protein Cse2 (CRISPR_cse2)	-	-	-	ko:K19046	-	-	-	-	ko00000,ko02048	-	-	-	CRISPR_Cse2
HKD2_k127_1341217_5	391037.Sare_1972	3.196e-136	451.0	29WDQ@1|root,30HZD@2|Bacteria,2HWU0@201174|Actinobacteria,4DKCD@85008|Micromonosporales	201174|Actinobacteria	S	CRISPR-associated protein Cse1 (CRISPR_cse1)	-	-	-	ko:K19123	-	-	-	-	ko00000,ko02048	-	-	-	CRISPR_Cse1
HKD2_k127_1341217_9	269800.Tfu_1593	7.206e-70	257.0	COG1203@1|root,COG1203@2|Bacteria,2GMM0@201174|Actinobacteria,4ENA9@85012|Streptosporangiales	201174|Actinobacteria	C	Metal dependent phosphohydrolases with conserved 'HD' motif.	cas3	-	-	ko:K07012,ko:K19123	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	DEAD,Helicase_C
HKD2_k127_1341217_4	1169152.AXVD01000032_gene3326	4.034e-143	475.0	COG1203@1|root,COG1203@2|Bacteria,2GMM0@201174|Actinobacteria,4G13V@85025|Nocardiaceae	201174|Actinobacteria	L	CRISPR-associated helicase Cas3	cas3	-	-	ko:K07012	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	DEAD,Helicase_C
HKD2_k127_1341217_17	1123024.AUII01000003_gene3474	1.709e-07	61.0	28VSD@1|root,2ZHU7@2|Bacteria,2GU9N@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1341217_11	1306174.JODP01000005_gene1594	5.27e-59	233.0	COG1376@1|root,COG1376@2|Bacteria,2INDP@201174|Actinobacteria	201174|Actinobacteria	S	ErfK YbiS YcfS YnhG family protein	-	-	-	-	-	-	-	-	-	-	-	-	YkuD
HKD2_k127_1341217_7	326424.FRAAL4405	8.7e-98	329.0	COG2267@1|root,COG2267@2|Bacteria,2GM96@201174|Actinobacteria,4EV7N@85013|Frankiales	201174|Actinobacteria	I	Alpha beta	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
HKD2_k127_1341217_8	1120950.KB892708_gene4367	2.193e-97	325.0	COG0491@1|root,COG0491@2|Bacteria,2HP5U@201174|Actinobacteria,4DT4G@85009|Propionibacteriales	201174|Actinobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HKD2_k127_1341217_15	351607.Acel_2036	1.791e-20	108.0	COG2172@1|root,COG2172@2|Bacteria	2|Bacteria	T	sigma factor antagonist activity	-	-	2.7.11.1	ko:K04757	-	-	-	-	ko00000,ko01000,ko01001,ko03021	-	-	-	HATPase_c_2
HKD2_k127_1341217_16	1157637.KB892091_gene5888	7.047e-20	94.0	COG2172@1|root,COG2172@2|Bacteria,2IKUS@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase-like ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c_2
HKD2_k127_1341217_13	526225.Gobs_1025	2.593e-51	209.0	COG1896@1|root,COG1896@2|Bacteria,2IGNT@201174|Actinobacteria	201174|Actinobacteria	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1341217_3	656024.FsymDg_1481	8.047e-165	544.0	COG1807@1|root,COG1807@2|Bacteria,2H4N7@201174|Actinobacteria,4EV7X@85013|Frankiales	201174|Actinobacteria	M	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family	-	-	-	-	-	-	-	-	-	-	-	-	PMT,PMT_2
HKD2_k127_1341217_6	1120948.KB903247_gene4535	1.021e-107	382.0	COG0491@1|root,COG0491@2|Bacteria,2HFVZ@201174|Actinobacteria,4DY1J@85010|Pseudonocardiales	201174|Actinobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	ko:K05555	ko01057,ko01130,map01057,map01130	M00778	R09305	-	ko00000,ko00001,ko00002,ko01000,ko01008	-	-	-	Lactamase_B
HKD2_k127_1341217_0	106370.Francci3_1148	3.483e-302	932.0	COG0488@1|root,COG0488@2|Bacteria,2GKBQ@201174|Actinobacteria,4ERN5@85013|Frankiales	201174|Actinobacteria	S	ABC transporter	yjjK	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	ABC_tran,ABC_tran_Xtn
HKD2_k127_1341217_10	656024.FsymDg_1483	5.513e-61	217.0	COG2346@1|root,COG2346@2|Bacteria,2IKPF@201174|Actinobacteria,4ESTB@85013|Frankiales	201174|Actinobacteria	S	PFAM globin	glbO	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008144,GO:0008150,GO:0015669,GO:0015671,GO:0015893,GO:0016020,GO:0019825,GO:0020037,GO:0036094,GO:0042221,GO:0042493,GO:0044464,GO:0046906,GO:0048037,GO:0050896,GO:0051179,GO:0051234,GO:0071944,GO:0097159,GO:1901363	-	ko:K06886	-	-	-	-	ko00000	-	-	-	Bac_globin
HKD2_k127_1341217_1	222534.KB893671_gene3084	5.797e-234	762.0	COG0366@1|root,COG0366@2|Bacteria,2GKS4@201174|Actinobacteria,4ERW2@85013|Frankiales	201174|Actinobacteria	G	SMART alpha amylase, catalytic sub domain	aglA	-	3.2.1.20	ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R06087,R06088	RC00028,RC00049,RC00077	ko00000,ko00001,ko01000	-	GH31	-	Alpha-amylase,DUF3459
HKD2_k127_1341217_2	1906.SFRA_19785	7.482e-216	679.0	COG0277@1|root,COG0277@2|Bacteria,2GJ2T@201174|Actinobacteria	201174|Actinobacteria	C	PFAM FAD linked oxidase domain protein	-	-	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
HKD2_k127_1341217_12	405948.SACE_4263	1.785e-56	222.0	COG0247@1|root,COG0247@2|Bacteria,2GIVX@201174|Actinobacteria,4DYFJ@85010|Pseudonocardiales	201174|Actinobacteria	C	Fe-S oxidoreductase	-	-	-	ko:K11473	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	CCG,Fer4_7,Fer4_8
HKD2_k127_1351897_5	306281.AJLK01000150_gene1961	1.468e-43	167.0	COG0827@1|root,COG0827@2|Bacteria,1G0Q3@1117|Cyanobacteria,1JKP9@1189|Stigonemataceae	1117|Cyanobacteria	L	BsuBI/PstI restriction endonuclease C-terminus	-	-	2.1.1.72	ko:K07317	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	BsuBI_PstI_RE,Eco57I
HKD2_k127_1351897_3	369723.Strop_0105	5.376e-59	207.0	COG0827@1|root,COG0827@2|Bacteria,2IA07@201174|Actinobacteria	201174|Actinobacteria	L	restriction endonuclease domain protein	-	-	3.1.21.4	ko:K01155	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	BsuBI_PstI_RE
HKD2_k127_1351897_6	351607.Acel_1867	5.409e-23	101.0	2E63U@1|root,330SV@2|Bacteria,2GSXM@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1351897_8	35754.JNYJ01000003_gene6399	0.0002898	49.0	291MK@1|root,2ZP7U@2|Bacteria,2GZJN@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1351897_1	1299327.I546_5694	4.947e-88	301.0	COG1752@1|root,COG1752@2|Bacteria,2GNBM@201174|Actinobacteria,234XD@1762|Mycobacteriaceae	201174|Actinobacteria	S	Contains patatin domain. This family consists of various patatin glycoproteins from plants. The patatin protein accounts for up to 40 of the total soluble protein in potato tubers. Patatin is a storage protein but it also has the enzymatic activity of lipid acyl hydrolase	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
HKD2_k127_1351897_2	1463934.JOCF01000033_gene5585	5.451e-83	304.0	COG1215@1|root,COG1215@2|Bacteria,2GJZI@201174|Actinobacteria	201174|Actinobacteria	M	Glycosyl transferase, family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3,Glycos_transf_2
HKD2_k127_1351897_4	67373.JOBF01000012_gene3953	6.976e-52	194.0	COG1215@1|root,COG1215@2|Bacteria,2GJZI@201174|Actinobacteria	201174|Actinobacteria	M	Glycosyl transferase, family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3,Glycos_transf_2
HKD2_k127_1351897_7	263358.VAB18032_26310	1.528e-19	90.0	COG0076@1|root,COG0076@2|Bacteria,2GK3J@201174|Actinobacteria,4D8KQ@85008|Micromonosporales	201174|Actinobacteria	E	Pyridoxal-dependent decarboxylase conserved domain	tdcA	-	4.1.1.105,4.1.1.28	ko:K01593	ko00350,ko00360,ko00380,ko00901,ko00950,ko00965,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00350,map00360,map00380,map00901,map00950,map00965,map01100,map01110,map04726,map04728,map05030,map05031,map05034	M00037,M00042	R00685,R00699,R00736,R02080,R02701,R04909	RC00299	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyridoxal_deC
HKD2_k127_1351897_0	1068980.ARVW01000001_gene4337	1.112e-144	463.0	COG0076@1|root,COG0076@2|Bacteria,2GK3J@201174|Actinobacteria,4E1JU@85010|Pseudonocardiales	201174|Actinobacteria	E	decarboxylase	tdcA	-	4.1.1.105,4.1.1.28	ko:K01593	ko00350,ko00360,ko00380,ko00901,ko00950,ko00965,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00350,map00360,map00380,map00901,map00950,map00965,map01100,map01110,map04726,map04728,map05030,map05031,map05034	M00037,M00042	R00685,R00699,R00736,R02080,R02701,R04909	RC00299	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyridoxal_deC
HKD2_k127_1353339_2	656024.FsymDg_0922	2.361e-148	475.0	COG1524@1|root,COG1524@2|Bacteria	2|Bacteria	S	mannose-ethanolamine phosphotransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	PE,Phosphodiest
HKD2_k127_1353339_0	326424.FRAAL6034	4.933e-229	738.0	COG0661@1|root,COG0661@2|Bacteria,2GJQ6@201174|Actinobacteria,4ES31@85013|Frankiales	201174|Actinobacteria	S	PFAM ABC-1 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	ABC1,APH
HKD2_k127_1353339_3	298655.KI912266_gene2017	2.25e-101	345.0	COG0476@1|root,COG0476@2|Bacteria,2GMJI@201174|Actinobacteria,4ET5V@85013|Frankiales	201174|Actinobacteria	H	UBA THIF-type NAD FAD binding	-	-	-	-	-	-	-	-	-	-	-	-	ThiF
HKD2_k127_1353339_7	1211815.CBYP010000042_gene2411	3.036e-19	94.0	2E479@1|root,32Z35@2|Bacteria,2GQXY@201174|Actinobacteria,4ETJU@85013|Frankiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1353339_4	2045.KR76_09330	2.2e-95	321.0	COG1024@1|root,COG1024@2|Bacteria,2I7QX@201174|Actinobacteria,4DRJV@85009|Propionibacteriales	201174|Actinobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	4.2.1.17	ko:K01692	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
HKD2_k127_1353339_6	1146883.BLASA_3958	3.811e-34	144.0	COG2337@1|root,COG2337@2|Bacteria,2IICB@201174|Actinobacteria	201174|Actinobacteria	T	PemK-like, MazF-like toxin of type II toxin-antitoxin system	-	-	-	ko:K07171	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PemK_toxin
HKD2_k127_1353339_9	1500306.JQLA01000003_gene4280	2.073e-16	81.0	2BE8N@1|root,327ZP@2|Bacteria,1Q937@1224|Proteobacteria,2V58Q@28211|Alphaproteobacteria,4BH9K@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Protein  of unknown function (DUF3018)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3018
HKD2_k127_1353339_5	1134445.AJJM01000009_gene2985	1.495e-63	226.0	COG1451@1|root,COG1451@2|Bacteria,2GMP6@201174|Actinobacteria	201174|Actinobacteria	S	metal-dependent hydrolase	-	-	-	ko:K07043	-	-	-	-	ko00000	-	-	-	DUF45
HKD2_k127_1353339_8	743718.Isova_2069	1.499e-17	97.0	COG3360@1|root,COG3360@2|Bacteria,2I0N2@201174|Actinobacteria,4F4X8@85017|Promicromonosporaceae	201174|Actinobacteria	S	Dodecin	-	-	-	ko:K09165	-	-	-	-	ko00000	-	-	-	Dodecin
HKD2_k127_1353339_1	298654.FraEuI1c_0772	5.456e-187	596.0	COG5282@1|root,COG5282@2|Bacteria,2GJ9K@201174|Actinobacteria,4ERD1@85013|Frankiales	201174|Actinobacteria	S	Zincin-like metallopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Zincin_2
HKD2_k127_1366577_2	58123.JOFJ01000008_gene383	3.147e-95	327.0	COG0122@1|root,COG0122@2|Bacteria,2GP69@201174|Actinobacteria,4EGGT@85012|Streptosporangiales	201174|Actinobacteria	L	3-methyladenine DNA glycosylase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1366577_0	106370.Francci3_0741	6.163e-187	593.0	COG0778@1|root,COG1478@1|root,COG0778@2|Bacteria,COG1478@2|Bacteria,2GMJ8@201174|Actinobacteria,4ERHZ@85013|Frankiales	201174|Actinobacteria	C	F420-dependent oxidoreductase	fbiB	GO:0005575,GO:0005623,GO:0005886,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016020,GO:0044237,GO:0044249,GO:0044464,GO:0051186,GO:0051188,GO:0071944	6.3.2.31,6.3.2.34	ko:K12234	ko00680,ko01120,map00680,map01120	M00378	R09399,R09400	RC00064,RC00090,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_ligase,Nitroreductase
HKD2_k127_1366577_1	298655.KI912266_gene151	2.641e-129	417.0	COG0391@1|root,COG0391@2|Bacteria,2GJZ2@201174|Actinobacteria,4ERBV@85013|Frankiales	201174|Actinobacteria	S	tigrfam lppg	cofD	GO:0003674,GO:0003824,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016740,GO:0016772,GO:0016773,GO:0043743,GO:0044237,GO:0044249,GO:0051186,GO:0051188	2.7.8.28	ko:K11212	ko00680,ko01120,map00680,map01120	M00378	R09398	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	UPF0052
HKD2_k127_136694_3	106370.Francci3_1050	4.03e-23	104.0	COG1572@1|root,COG1572@2|Bacteria,2I56C@201174|Actinobacteria,4EXBH@85013|Frankiales	201174|Actinobacteria	S	Domain of unknown function (DUF3367)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3367
HKD2_k127_136694_4	1394178.AWOO02000043_gene5839	2.202e-09	66.0	COG0657@1|root,COG0657@2|Bacteria,2I5U9@201174|Actinobacteria	201174|Actinobacteria	I	acetylesterase activity	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S9
HKD2_k127_136694_5	66377.JOBH01000006_gene42	5.376e-07	62.0	COG1073@1|root,COG1073@2|Bacteria,2I2V0@201174|Actinobacteria	201174|Actinobacteria	S	alpha beta	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S9
HKD2_k127_136694_2	1122182.KB903834_gene6201	6.064e-24	117.0	COG0657@1|root,COG0657@2|Bacteria,2I5U9@201174|Actinobacteria,4DMDY@85008|Micromonosporales	201174|Actinobacteria	I	acetylesterase activity	-	-	-	-	-	-	-	-	-	-	-	-	Esterase,Peptidase_S9
HKD2_k127_136694_1	298653.Franean1_5450	1.415e-70	243.0	COG0563@1|root,COG0563@2|Bacteria,2IGX9@201174|Actinobacteria,4EWJ4@85013|Frankiales	201174|Actinobacteria	F	adenylate kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	AAA,AAA_33,SKI
HKD2_k127_136694_0	222534.KB893783_gene5223	0.0	1017.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,2GJY2@201174|Actinobacteria,4ES9K@85013|Frankiales	201174|Actinobacteria	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	GO:0003674,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0030312,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901362,GO:1901576	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
HKD2_k127_1370493_4	656024.FsymDg_1644	1.05e-66	232.0	COG0568@1|root,COG0568@2|Bacteria,2GK3Z@201174|Actinobacteria,4ERX9@85013|Frankiales	201174|Actinobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	sigA	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
HKD2_k127_1370493_1	656024.FsymDg_1643	4.172e-291	910.0	COG0358@1|root,COG0358@2|Bacteria,2GJFX@201174|Actinobacteria,4ERCW@85013|Frankiales	201174|Actinobacteria	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB_bind,DnaG_DnaB_bind,Toprim_4,Toprim_N,zf-CHC2
HKD2_k127_1370493_2	656024.FsymDg_1642	5.999e-173	556.0	COG0232@1|root,COG0232@2|Bacteria,2GJ8F@201174|Actinobacteria,4ES2H@85013|Frankiales	201174|Actinobacteria	F	SMART Metal-dependent phosphohydrolase, HD region	dgt	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008832,GO:0009056,GO:0009058,GO:0009117,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009151,GO:0009155,GO:0009166,GO:0009200,GO:0009204,GO:0009215,GO:0009217,GO:0009262,GO:0009264,GO:0009394,GO:0009987,GO:0016020,GO:0016787,GO:0016788,GO:0016793,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042578,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046070,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576	3.1.5.1	ko:K01129	ko00230,map00230	-	R01856	RC00017	ko00000,ko00001,ko01000	-	-	-	HD,HD_assoc
HKD2_k127_1370493_5	656024.FsymDg_1640	1.162e-59	211.0	COG3428@1|root,COG3428@2|Bacteria,2IA1C@201174|Actinobacteria	201174|Actinobacteria	K	PFAM Bacterial membrane flanked domain	-	-	-	-	-	-	-	-	-	-	-	-	bPH_2
HKD2_k127_1370493_3	710111.FraQA3DRAFT_3023	2.434e-70	247.0	COG1434@1|root,COG1434@2|Bacteria,2I2NF@201174|Actinobacteria,4ET60@85013|Frankiales	201174|Actinobacteria	S	DUF218 domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF218
HKD2_k127_1370493_0	351607.Acel_0801	0.0	1454.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,2GK73@201174|Actinobacteria,4ERQZ@85013|Frankiales	201174|Actinobacteria	G	pyruvate phosphate dikinase, PEP	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
HKD2_k127_1370493_6	469383.Cwoe_2021	3.524e-17	81.0	COG4113@1|root,COG4113@2|Bacteria	469383.Cwoe_2021|-	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1372844_0	656024.FsymDg_0624	0.0	1155.0	COG0247@1|root,COG0247@2|Bacteria,2GJ7M@201174|Actinobacteria,4ERT4@85013|Frankiales	201174|Actinobacteria	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	fadF	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8
HKD2_k127_1372844_1	106370.Francci3_4349	8.659e-115	371.0	COG0717@1|root,COG0717@2|Bacteria,2GKQQ@201174|Actinobacteria,4ERKX@85013|Frankiales	201174|Actinobacteria	F	Belongs to the dCTP deaminase family	dcd	GO:0003674,GO:0003824,GO:0004170,GO:0016462,GO:0016787,GO:0016810,GO:0016814,GO:0016817,GO:0016818,GO:0019239,GO:0033973,GO:0047429	3.5.4.13	ko:K01494	ko00240,ko01100,map00240,map01100	M00053	R00568,R02325	RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	DCD
HKD2_k127_1372844_3	105425.BBPL01000002_gene6534	5.36e-87	301.0	COG0582@1|root,COG0582@2|Bacteria,2GISN@201174|Actinobacteria,2NH95@228398|Streptacidiphilus	201174|Actinobacteria	L	Phage integrase family	intA	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_3,Phage_integrase
HKD2_k127_1372844_4	1352941.M877_18175	1.318e-11	67.0	2EQWD@1|root,33IG7@2|Bacteria,2GQNK@201174|Actinobacteria	201174|Actinobacteria	S	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_17
HKD2_k127_1372844_2	710111.FraQA3DRAFT_4486	1.284e-112	377.0	COG0484@1|root,COG0484@2|Bacteria,2GIXJ@201174|Actinobacteria	201174|Actinobacteria	O	Replication initiator protein	repSA1	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1407801_1	649638.Trad_1031	1.008e-136	444.0	COG0366@1|root,COG0366@2|Bacteria,1WIXP@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	G	PFAM alpha amylase, catalytic	-	-	2.4.1.4	ko:K05341	ko00500,map00500	-	R01823	RC00028	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase
HKD2_k127_1407801_10	1210045.ALNP01000013_gene1337	4.28e-06	59.0	COG1396@1|root,COG1396@2|Bacteria,2GMS9@201174|Actinobacteria	201174|Actinobacteria	K	sequence-specific DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1407801_3	106370.Francci3_3612	1.15e-123	406.0	COG0351@1|root,COG0351@2|Bacteria,2GKZM@201174|Actinobacteria,4ESRD@85013|Frankiales	201174|Actinobacteria	H	PFAM Phosphomethylpyrimidine kinase type-1	thiD	GO:0008150,GO:0040007	2.7.1.49,2.7.4.7	ko:K00941	ko00730,ko01100,map00730,map01100	M00127	R03471,R04509	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Phos_pyr_kin
HKD2_k127_1407801_5	1040983.AXAE01000012_gene2107	1.024e-87	304.0	COG0402@1|root,COG0402@2|Bacteria,1MX34@1224|Proteobacteria,2U0IN@28211|Alphaproteobacteria,43N8W@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	F	Amidohydrolase family	-	-	3.5.4.1	ko:K01485	ko00240,ko00330,ko01100,map00240,map00330,map01100	-	R00974,R01411,R02922	RC00074,RC00514,RC00809	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1,Amidohydro_3,MGS
HKD2_k127_1407801_4	656024.FsymDg_3697	1.2e-122	400.0	COG0611@1|root,COG0611@2|Bacteria,2GP6E@201174|Actinobacteria,4ERCE@85013|Frankiales	201174|Actinobacteria	H	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1	thiL	GO:0008150,GO:0040007	2.7.4.16	ko:K00946	ko00730,ko01100,map00730,map01100	M00127	R00617	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv2977c	AIRS,AIRS_C
HKD2_k127_1407801_7	471852.Tcur_3444	2.596e-34	133.0	COG1522@1|root,COG1522@2|Bacteria,2IQ4Z@201174|Actinobacteria,4EKJP@85012|Streptosporangiales	201174|Actinobacteria	K	Lrp/AsnC ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg
HKD2_k127_1407801_6	656024.FsymDg_3699	7.712e-35	143.0	2ECK0@1|root,33FNE@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF3515)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3515
HKD2_k127_1407801_0	656024.FsymDg_3700	2.743e-157	503.0	COG1181@1|root,COG1181@2|Bacteria,2GITC@201174|Actinobacteria,4ERWT@85013|Frankiales	201174|Actinobacteria	M	Belongs to the D-alanine--D-alanine ligase family	ddl	GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008716,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0040007,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C,Dala_Dala_lig_N
HKD2_k127_1407801_2	1380356.JNIK01000016_gene3791	3.545e-136	442.0	COG0240@1|root,COG0240@2|Bacteria,2GJSD@201174|Actinobacteria,4ERKS@85013|Frankiales	201174|Actinobacteria	I	Glycerol-3-phosphate dehydrogenase	gpsA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	1.1.1.94	ko:K00057	ko00564,ko01110,map00564,map01110	-	R00842,R00844	RC00029	ko00000,ko00001,ko01000	-	-	-	NAD_Gly3P_dh_C,NAD_Gly3P_dh_N
HKD2_k127_1407801_9	66429.JOFL01000030_gene5153	1.635e-17	85.0	COG0204@1|root,COG0204@2|Bacteria,2GKVA@201174|Actinobacteria	201174|Actinobacteria	I	Acyltransferase	plsC2	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
HKD2_k127_1424586_1	710111.FraQA3DRAFT_4757	2.444e-159	514.0	COG3225@1|root,COG3225@2|Bacteria,2GMTX@201174|Actinobacteria,4ESFT@85013|Frankiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1424586_6	222534.KB893717_gene2162	2.205e-24	106.0	2ETMT@1|root,33M5J@2|Bacteria,2HU3T@201174|Actinobacteria,4EWV2@85013|Frankiales	201174|Actinobacteria	S	Protein of unknown function (DUF2530)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2530
HKD2_k127_1424586_0	1463926.JOCA01000018_gene1005	3.926e-172	554.0	COG2252@1|root,COG2252@2|Bacteria,2GKYD@201174|Actinobacteria	201174|Actinobacteria	S	permease	-	-	-	ko:K06901	-	-	-	-	ko00000,ko02000	2.A.1.40	-	-	Xan_ur_permease
HKD2_k127_1424586_10	656024.FsymDg_0257	0.0001109	46.0	COG1846@1|root,COG1846@2|Bacteria,2IFQ9@201174|Actinobacteria,4ET3M@85013|Frankiales	201174|Actinobacteria	K	PFAM regulatory protein, MarR	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
HKD2_k127_1424586_3	656024.FsymDg_0256	1.675e-101	344.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
HKD2_k127_1424586_5	446462.Amir_2815	6.52e-27	128.0	COG0500@1|root,COG2226@2|Bacteria,2II6W@201174|Actinobacteria	201174|Actinobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
HKD2_k127_1424586_2	1121272.KB903283_gene5004	3.038e-112	376.0	COG0715@1|root,COG0715@2|Bacteria,2I95I@201174|Actinobacteria	201174|Actinobacteria	P	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1424586_8	710111.FraQA3DRAFT_0487	1.079e-09	63.0	COG2801@1|root,COG2801@2|Bacteria,2GNRT@201174|Actinobacteria,4EUFJ@85013|Frankiales	201174|Actinobacteria	L	Evidence 2b Function of strongly homologous gene	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	rve,rve_3
HKD2_k127_1424586_9	345341.KUTG_07540	3.874e-06	53.0	COG3385@1|root,COG3385@2|Bacteria,2H68X@201174|Actinobacteria,4EAUY@85010|Pseudonocardiales	201174|Actinobacteria	L	Transposase DDE domain group 1	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_4
HKD2_k127_1424586_4	345341.KUTG_07540	5.578e-44	167.0	COG3385@1|root,COG3385@2|Bacteria,2H68X@201174|Actinobacteria,4EAUY@85010|Pseudonocardiales	201174|Actinobacteria	L	Transposase DDE domain group 1	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_4
HKD2_k127_1436359_0	656024.FsymDg_4451	3.525e-121	401.0	COG1215@1|root,COG2246@1|root,COG1215@2|Bacteria,COG2246@2|Bacteria,2GJTE@201174|Actinobacteria,4ES8M@85013|Frankiales	201174|Actinobacteria	M	glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2,GtrA
HKD2_k127_1436359_7	751944.HALDL1_10435	1.417e-07	61.0	COG3540@1|root,arCOG09293@2157|Archaea,2XUB8@28890|Euryarchaeota,23T9V@183963|Halobacteria	183963|Halobacteria	P	COG3540 Phosphodiesterase alkaline phosphatase D	-	-	3.1.3.1	ko:K01113	ko00790,ko01100,ko02020,map00790,map01100,map02020	M00126	R04620	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PhoD,PhoD_N
HKD2_k127_1436359_1	298655.KI912266_gene5611	5.005e-97	334.0	COG1131@1|root,COG1131@2|Bacteria,2GN8P@201174|Actinobacteria,4EV93@85013|Frankiales	201174|Actinobacteria	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD2_k127_1436359_6	222534.KB893671_gene3105	7.128e-12	73.0	COG1277@1|root,COG1277@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane_2,ABC2_membrane_4
HKD2_k127_1436359_3	1120950.KB892745_gene2948	3.379e-50	186.0	COG1848@1|root,COG1848@2|Bacteria,2GRA5@201174|Actinobacteria,4DUUT@85009|Propionibacteriales	201174|Actinobacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
HKD2_k127_1436359_4	1156844.KB891820_gene483	6.061e-34	133.0	COG4118@1|root,COG4118@2|Bacteria,2GSMM@201174|Actinobacteria	201174|Actinobacteria	D	Antitoxin Phd_YefM, type II toxin-antitoxin system	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
HKD2_k127_1436359_5	1380393.JHVP01000001_gene2470	4.71e-23	108.0	COG2350@1|root,COG2350@2|Bacteria,2GS0M@201174|Actinobacteria	201174|Actinobacteria	S	YCII-related domain	-	-	-	ko:K09780	-	-	-	-	ko00000	-	-	-	YCII
HKD2_k127_1436359_2	469383.Cwoe_4234	9.191e-69	240.0	COG3865@1|root,COG3865@2|Bacteria,2IIAX@201174|Actinobacteria,4CSWP@84995|Rubrobacteria	84995|Rubrobacteria	S	3-demethylubiquinone-9 3-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	3-dmu-9_3-mt
HKD2_k127_143856_1	1380354.JIAN01000009_gene3754	6.28e-39	167.0	COG4965@1|root,COG4965@2|Bacteria,2GN6E@201174|Actinobacteria	201174|Actinobacteria	U	type II secretion system	-	-	-	-	-	-	-	-	-	-	-	-	T2SSF
HKD2_k127_143856_0	28444.JODQ01000002_gene4267	2.382e-104	358.0	COG4962@1|root,COG4962@2|Bacteria,2GKKJ@201174|Actinobacteria,4EHJY@85012|Streptosporangiales	201174|Actinobacteria	U	Type II/IV secretion system protein	-	-	-	ko:K02283	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
HKD2_k127_143856_2	1211815.CBYP010000061_gene19	4.388e-32	145.0	COG0455@1|root,COG0455@2|Bacteria,2HT5K@201174|Actinobacteria,4EW2K@85013|Frankiales	201174|Actinobacteria	D	bacterial-type flagellum organization	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_143856_3	1211815.CBYP010000061_gene20	1.109e-20	105.0	COG1261@1|root,COG1261@2|Bacteria,2IR93@201174|Actinobacteria,4ETJ2@85013|Frankiales	201174|Actinobacteria	NO	SAF	-	-	-	-	-	-	-	-	-	-	-	-	SAF
HKD2_k127_143856_4	222534.KB893793_gene2439	5.252e-06	59.0	2E4ST@1|root,32ZM5@2|Bacteria,2GSCH@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Tad
HKD2_k127_143856_5	365528.KB891250_gene5840	2.821e-05	55.0	COG4961@1|root,COG4961@2|Bacteria,2GRCJ@201174|Actinobacteria,4ET7Q@85013|Frankiales	201174|Actinobacteria	U	TadE-like protein	-	-	-	-	-	-	-	-	-	-	-	-	TadE
HKD2_k127_1451767_0	627192.SLG_07010	1.32e-77	269.0	COG3546@1|root,COG3546@2|Bacteria,1MUHB@1224|Proteobacteria,2TUU8@28211|Alphaproteobacteria,2K26H@204457|Sphingomonadales	204457|Sphingomonadales	P	Manganese containing catalase	-	-	-	ko:K07217	-	-	-	-	ko00000	-	-	-	Mn_catalase
HKD2_k127_1451767_1	1380393.JHVP01000009_gene1325	1.053e-38	149.0	COG2017@1|root,COG2017@2|Bacteria,2GJ0H@201174|Actinobacteria,4ESW8@85013|Frankiales	201174|Actinobacteria	G	Aldose 1-epimerase	-	-	5.1.3.3	ko:K01785	ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130	M00632	R01602,R10619	RC00563	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldose_epim,SKI
HKD2_k127_1463859_1	656024.FsymDg_3808	2.734e-133	443.0	COG0515@1|root,COG0515@2|Bacteria	656024.FsymDg_3808|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1463859_0	656024.FsymDg_3809	1.264e-263	826.0	COG0443@1|root,COG0443@2|Bacteria,2GP0X@201174|Actinobacteria,4EX26@85013|Frankiales	201174|Actinobacteria	O	heat shock protein 70	-	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
HKD2_k127_1463859_4	106370.Francci3_3674	4.809e-60	224.0	COG0576@1|root,COG0576@2|Bacteria,2GW3Z@201174|Actinobacteria	201174|Actinobacteria	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	-	-	-	-	-	-	-	-	-	-	-	-	GrpE
HKD2_k127_1463859_5	1394178.AWOO02000048_gene6353	1.009e-29	127.0	COG2310@1|root,COG2310@2|Bacteria,2GJMM@201174|Actinobacteria	201174|Actinobacteria	T	Stress protein	-	-	-	ko:K05791	-	-	-	-	ko00000	-	-	-	TerD
HKD2_k127_1463859_2	298653.Franean1_1057	2.625e-104	342.0	COG4110@1|root,COG4110@2|Bacteria,2I2NY@201174|Actinobacteria,4EV9S@85013|Frankiales	201174|Actinobacteria	S	tellurium resistance protein	-	-	-	ko:K05792	-	-	-	-	ko00000	-	-	-	-
HKD2_k127_1463859_3	656024.FsymDg_3812	4.619e-95	316.0	COG2899@1|root,COG2899@2|Bacteria,2GJNH@201174|Actinobacteria,4ES65@85013|Frankiales	201174|Actinobacteria	S	Protein of unknown function (DUF475)	-	-	-	ko:K09799	-	-	-	-	ko00000	-	-	-	DUF475
HKD2_k127_1472152_4	1122997.AUDD01000004_gene1273	1.19e-20	99.0	COG3103@1|root,COG4991@2|Bacteria,2IPFM@201174|Actinobacteria	201174|Actinobacteria	T	sh3 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1472152_0	298655.KI912266_gene3041	0.0	1193.0	COG2352@1|root,COG2352@2|Bacteria,2GKDB@201174|Actinobacteria,4ERFY@85013|Frankiales	201174|Actinobacteria	C	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle	ppc	GO:0003674,GO:0003824,GO:0004611,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008964,GO:0016829,GO:0016830,GO:0016831,GO:0044424,GO:0044444,GO:0044464	4.1.1.31	ko:K01595	ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200	M00168,M00170,M00171,M00172,M00173,M00346,M00374	R00345	RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPcase
HKD2_k127_1472152_5	1306174.JODP01000017_gene4263	3.635e-19	101.0	COG5001@1|root,COG5001@2|Bacteria	2|Bacteria	T	cyclic-guanylate-specific phosphodiesterase activity	-	-	-	-	-	-	-	-	-	-	-	-	CHASE4,GGDEF,MASE3,PAS_4,PAS_8,PAS_9,PilJ,SBP_bac_3
HKD2_k127_1472152_6	596151.DesfrDRAFT_4062	6.375e-06	54.0	COG2199@1|root,COG3706@2|Bacteria,1MZV7@1224|Proteobacteria,430C9@68525|delta/epsilon subdivisions,2WW48@28221|Deltaproteobacteria,2MA0P@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	TIGRFAM Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
HKD2_k127_1472152_1	222534.KB893750_gene4275	2.522e-81	286.0	COG0501@1|root,COG0501@2|Bacteria,2GM27@201174|Actinobacteria,4EVXI@85013|Frankiales	201174|Actinobacteria	O	PFAM peptidase M48 Ste24p	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
HKD2_k127_1472152_3	710111.FraQA3DRAFT_4329	5.372e-45	166.0	COG3682@1|root,COG3682@2|Bacteria,2GRHV@201174|Actinobacteria,4ETDA@85013|Frankiales	201174|Actinobacteria	K	PFAM Penicillinase repressor	-	-	-	-	-	-	-	-	-	-	-	-	Penicillinase_R
HKD2_k127_1472152_2	326424.FRAAL0600	3.836e-72	250.0	COG1266@1|root,COG1266@2|Bacteria,2GK11@201174|Actinobacteria,4ESXA@85013|Frankiales	201174|Actinobacteria	S	PFAM Abortive infection protein	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
HKD2_k127_1514492_9	365528.KB891219_gene1138	1.714e-76	263.0	COG0399@1|root,COG0399@2|Bacteria,2IEA4@201174|Actinobacteria	201174|Actinobacteria	M	DegT/DnrJ/EryC1/StrS aminotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
HKD2_k127_1514492_25	352165.HMPREF7215_2203	3.744e-05	48.0	COG2148@1|root,COG2148@2|Bacteria,3TATP@508458|Synergistetes	508458|Synergistetes	M	sugar transferase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_transf
HKD2_k127_1514492_19	1150864.MILUP08_44176	4.543e-27	114.0	COG3293@1|root,COG3293@2|Bacteria,2IIMK@201174|Actinobacteria,4DJ4B@85008|Micromonosporales	201174|Actinobacteria	L	Evidence 2b Function of strongly homologous gene	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_2
HKD2_k127_1514492_18	1123320.KB889742_gene5145	2.234e-29	131.0	COG4636@1|root,COG4636@2|Bacteria,2ISMA@201174|Actinobacteria	201174|Actinobacteria	S	Putative restriction endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	Uma2
HKD2_k127_1514492_26	497964.CfE428DRAFT_6344	5.684e-05	46.0	COG5573@1|root,COG5573@2|Bacteria	2|Bacteria	K	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
HKD2_k127_1514492_13	266940.Krad_3904	1.438e-57	221.0	COG0041@1|root,COG0041@2|Bacteria,2IFFD@201174|Actinobacteria	201174|Actinobacteria	F	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)	purE	GO:0008150,GO:0040007	5.4.99.18	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07405	RC01947	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv3275c	AIRC
HKD2_k127_1514492_2	1150864.MILUP08_41024	1.136e-136	451.0	COG0026@1|root,COG0026@2|Bacteria,2GJCU@201174|Actinobacteria,4D90F@85008|Micromonosporales	201174|Actinobacteria	F	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)	purK	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944	6.3.4.18	ko:K01589	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07404	RC01927	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp
HKD2_k127_1514492_17	1068980.ARVW01000001_gene5605	2.786e-31	138.0	COG4636@1|root,COG4636@2|Bacteria,2IQYX@201174|Actinobacteria,4E6BN@85010|Pseudonocardiales	201174|Actinobacteria	S	Putative restriction endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	Uma2
HKD2_k127_1514492_15	326424.FRAAL2037	2.739e-35	144.0	COG0394@1|root,COG0394@2|Bacteria,2GMPR@201174|Actinobacteria,4ET83@85013|Frankiales	201174|Actinobacteria	T	low molecular weight	etp	-	3.1.3.48	ko:K01104	-	-	-	-	ko00000,ko01000	-	-	-	LMWPc
HKD2_k127_1514492_1	105420.BBPO01000036_gene527	1.293e-170	551.0	COG0677@1|root,COG0677@2|Bacteria,2GK5K@201174|Actinobacteria,2NEJQ@228398|Streptacidiphilus	201174|Actinobacteria	M	UDP binding domain	wecC	-	1.1.1.136,1.1.1.336	ko:K02472,ko:K13015	ko00520,ko05111,map00520,map05111	-	R00421,R03317	RC00291	ko00000,ko00001,ko01000,ko01005	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
HKD2_k127_1514492_16	1032480.MLP_25770	5.65e-35	143.0	COG0673@1|root,COG0673@2|Bacteria,2GJCY@201174|Actinobacteria,4DPWQ@85009|Propionibacteriales	201174|Actinobacteria	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
HKD2_k127_1514492_8	1123065.ATWL01000023_gene3603	4.859e-77	266.0	COG0673@1|root,COG0673@2|Bacteria,2GJCY@201174|Actinobacteria	201174|Actinobacteria	G	Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose)	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
HKD2_k127_1514492_23	105420.BBPO01000036_gene524	7.776e-08	64.0	COG0399@1|root,COG0399@2|Bacteria,2GKD7@201174|Actinobacteria,2NGSV@228398|Streptacidiphilus	201174|Actinobacteria	M	DegT/DnrJ/EryC1/StrS aminotransferase family	degT	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
HKD2_k127_1514492_3	888050.HMPREF9004_0335	1.529e-107	364.0	COG0399@1|root,COG0399@2|Bacteria,2GKD7@201174|Actinobacteria,4D4G3@85005|Actinomycetales	201174|Actinobacteria	E	Belongs to the DegT DnrJ EryC1 family	degT	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
HKD2_k127_1514492_10	1449353.JQMQ01000005_gene1926	2.134e-70	246.0	COG0110@1|root,COG0110@2|Bacteria,2H5M0@201174|Actinobacteria,2NHYA@228398|Streptacidiphilus	201174|Actinobacteria	S	Hexapeptide repeat of succinyl-transferase	wbpD	-	-	-	-	-	-	-	-	-	-	-	Hexapep,Hexapep_2
HKD2_k127_1514492_14	760568.Desku_1734	1.338e-56	206.0	COG0399@1|root,COG0399@2|Bacteria,1TPDH@1239|Firmicutes,24G9G@186801|Clostridia,264B5@186807|Peptococcaceae	186801|Clostridia	M	Belongs to the DegT DnrJ EryC1 family	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
HKD2_k127_1514492_4	326424.FRAAL5660	7.766e-92	332.0	COG0489@1|root,COG3944@1|root,COG0489@2|Bacteria,COG3944@2|Bacteria,2GJ1Y@201174|Actinobacteria,4ERN0@85013|Frankiales	201174|Actinobacteria	DM	PFAM lipopolysaccharide biosynthesis protein	-	-	2.7.10.2	ko:K08253	-	-	-	-	ko00000,ko01000	-	-	-	AAA_31,CbiA,ParA,Wzz
HKD2_k127_1514492_5	365528.KB891241_gene6274	1.026e-87	313.0	COG2976@1|root,COG2976@2|Bacteria,2GNIS@201174|Actinobacteria,4ETXP@85013|Frankiales	201174|Actinobacteria	S	Protein of unknown function (DUF4012)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4012
HKD2_k127_1514492_11	298655.KI912266_gene6522	6.478e-61	220.0	COG2976@1|root,COG2976@2|Bacteria,2GNIS@201174|Actinobacteria,4ETXP@85013|Frankiales	201174|Actinobacteria	S	Protein of unknown function (DUF4012)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4012
HKD2_k127_1514492_24	298653.Franean1_1274	6.71e-07	59.0	COG3266@1|root,COG3266@2|Bacteria	2|Bacteria	GM	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF4335,TbpB_B_D
HKD2_k127_1514492_0	656024.FsymDg_4480	1.639e-258	805.0	COG0166@1|root,COG0166@2|Bacteria,2GJG0@201174|Actinobacteria,4ETZY@85013|Frankiales	201174|Actinobacteria	G	Belongs to the GPI family	pgi	-	5.3.1.9	ko:K01810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114	R02739,R02740,R03321	RC00376,RC00563	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGI
HKD2_k127_1514492_21	485913.Krac_4003	2.383e-14	85.0	2E4G6@1|root,335WF@2|Bacteria,2G9R2@200795|Chloroflexi	200795|Chloroflexi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1514492_7	219305.MCAG_05393	7.035e-80	289.0	COG1018@1|root,COG1018@2|Bacteria,2HU15@201174|Actinobacteria,4DA7T@85008|Micromonosporales	201174|Actinobacteria	C	Oxidoreductase FAD-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_6,NAD_binding_1
HKD2_k127_1514492_6	443906.CMM_1423	5.267e-87	292.0	COG2041@1|root,COG2041@2|Bacteria,2GMG2@201174|Actinobacteria,4FNGK@85023|Microbacteriaceae	201174|Actinobacteria	S	Oxidoreductase molybdopterin binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_molyb
HKD2_k127_1514492_12	365528.KB891230_gene1966	1.652e-58	209.0	COG0735@1|root,COG0735@2|Bacteria,2IKS3@201174|Actinobacteria,4ESZF@85013|Frankiales	201174|Actinobacteria	P	Belongs to the Fur family	-	-	-	ko:K03711	-	-	-	-	ko00000,ko03000	-	-	-	FUR
HKD2_k127_1524060_0	656024.FsymDg_3249	7.888e-209	653.0	COG0504@1|root,COG0504@2|Bacteria,2GJ13@201174|Actinobacteria,4ERGE@85013|Frankiales	201174|Actinobacteria	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv1699	CTP_synth_N,GATase
HKD2_k127_1524060_4	326424.FRAAL5178	1.332e-76	269.0	COG0494@1|root,COG0494@2|Bacteria,2GNW6@201174|Actinobacteria,4ESWK@85013|Frankiales	201174|Actinobacteria	L	PFAM NUDIX hydrolase	nudF	-	3.6.1.13	ko:K01515	ko00230,map00230	-	R01054	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX
HKD2_k127_1524060_1	477641.MODMU_1492	1.851e-185	594.0	COG0402@1|root,COG0402@2|Bacteria,2GM63@201174|Actinobacteria	201174|Actinobacteria	F	Pfam Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
HKD2_k127_1524060_2	391037.Sare_1914	4.633e-166	536.0	COG0686@1|root,COG0686@2|Bacteria,2GJ6G@201174|Actinobacteria,4DA3S@85008|Micromonosporales	201174|Actinobacteria	C	Belongs to the AlaDH PNT family	ald	-	1.4.1.1	ko:K00259	ko00250,ko00430,ko01100,map00250,map00430,map01100	-	R00396	RC00008	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
HKD2_k127_1524060_3	656024.FsymDg_3245	3.501e-129	421.0	COG4974@1|root,COG4974@2|Bacteria,2GNDP@201174|Actinobacteria,4ERC1@85013|Frankiales	201174|Actinobacteria	L	tyrosine recombinase	xerD	GO:0008150,GO:0040007	-	ko:K03733,ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
HKD2_k127_1524060_5	656024.FsymDg_1788	3.263e-43	162.0	COG1192@1|root,COG1192@2|Bacteria,2GJX3@201174|Actinobacteria,4ERYA@85013|Frankiales	201174|Actinobacteria	D	PFAM Cobyrinic acid a,c-diamide synthase	soj	GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0008150,GO:0009295,GO:0016020,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044424,GO:0044464,GO:0071944	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
HKD2_k127_1542170_2	644966.Tmar_0217	8.467e-11	65.0	COG0337@1|root,COG0703@1|root,COG0337@2|Bacteria,COG0703@2|Bacteria,1TPKZ@1239|Firmicutes,248H4@186801|Clostridia,3WCII@538999|Clostridiales incertae sedis	186801|Clostridia	E	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)	aroB	-	2.7.1.71,4.2.3.4	ko:K01735,ko:K13829	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412,R03083	RC00002,RC00078,RC00847	ko00000,ko00001,ko00002,ko01000	-	-	-	DHQ_synthase
HKD2_k127_1542170_0	106370.Francci3_3132	4.758e-164	527.0	COG0404@1|root,COG0404@2|Bacteria,2GJ47@201174|Actinobacteria,4ES11@85013|Frankiales	201174|Actinobacteria	E	The glycine cleavage system catalyzes the degradation of glycine	gcvT	GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030312,GO:0040007,GO:0044464,GO:0071944	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	GCV_T,GCV_T_C
HKD2_k127_1542170_1	1229205.BUPH_01539	1.304e-130	434.0	COG4409@1|root,COG4409@2|Bacteria,1Q513@1224|Proteobacteria,2WB3C@28216|Betaproteobacteria,1K536@119060|Burkholderiaceae	28216|Betaproteobacteria	G	BNR repeat-like domain	-	-	-	-	-	-	-	-	-	-	-	-	BNR,BNR_2
HKD2_k127_1542425_6	222534.KB893683_gene1183	9.331e-39	166.0	COG2084@1|root,COG2084@2|Bacteria,2GNB0@201174|Actinobacteria,4EWCI@85013|Frankiales	201174|Actinobacteria	I	PFAM 6-phosphogluconate dehydrogenase NAD-binding	-	-	1.1.1.31,1.1.1.60	ko:K00020,ko:K00042	ko00280,ko00630,ko01100,map00280,map00630,map01100	-	R01745,R01747,R05066	RC00099	ko00000,ko00001,ko01000	-	-	-	Lumazine_bd_2,NAD_binding_11,NAD_binding_2,Ribonuc_L-PSP
HKD2_k127_1542425_0	644966.Tmar_1398	2.582e-242	758.0	COG2225@1|root,COG2225@2|Bacteria,1TPE8@1239|Firmicutes,24Z0I@186801|Clostridia	186801|Clostridia	H	Belongs to the malate synthase family	-	-	2.3.3.9	ko:K01638	ko00620,ko00630,ko01100,ko01110,ko01120,ko01200,map00620,map00630,map01100,map01110,map01120,map01200	M00012	R00472	RC00004,RC00308,RC02747	ko00000,ko00001,ko00002,ko01000	-	-	-	Malate_synthase
HKD2_k127_1542425_1	134676.ACPL_3077	1.306e-213	685.0	COG0277@1|root,COG0277@2|Bacteria,2GJ2T@201174|Actinobacteria,4DBYC@85008|Micromonosporales	201174|Actinobacteria	C	FAD linked oxidases, C-terminal domain	glcD	-	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
HKD2_k127_1542425_4	526225.Gobs_4800	1.959e-90	317.0	COG0277@1|root,COG0277@2|Bacteria,2GJ2T@201174|Actinobacteria,4ETS6@85013|Frankiales	201174|Actinobacteria	C	PFAM FAD linked oxidase domain protein	-	-	1.1.2.4,1.1.3.15	ko:K00102,ko:K00104,ko:K11472	ko00620,ko00630,ko01100,ko01110,ko01120,ko01130,map00620,map00630,map01100,map01110,map01120,map01130	-	R00197,R00475	RC00042,RC00044	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
HKD2_k127_1542425_5	1068978.AMETH_3854	5.781e-59	223.0	COG0247@1|root,COG0247@2|Bacteria,2GIVX@201174|Actinobacteria,4DYFJ@85010|Pseudonocardiales	201174|Actinobacteria	C	Fe-S oxidoreductase	glcF	-	-	ko:K11473	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	CCG,Fer4_7,Fer4_8
HKD2_k127_1542425_3	1463857.JOFZ01000004_gene2984	4.221e-126	419.0	COG0247@1|root,COG0247@2|Bacteria,2GIVX@201174|Actinobacteria	201174|Actinobacteria	C	Fe-S oxidoreductase	glcF	-	-	ko:K11473	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	CCG,Fer4_7,Fer4_8
HKD2_k127_1542425_2	710686.Mycsm_06334	4.042e-185	600.0	COG1620@1|root,COG1620@2|Bacteria,2GIUF@201174|Actinobacteria,23647@1762|Mycobacteriaceae	201174|Actinobacteria	C	L-lactate permease	lctP	-	-	ko:K03303	-	-	-	-	ko00000,ko02000	2.A.14	-	-	Lactate_perm
HKD2_k127_1556538_5	710111.FraQA3DRAFT_6299	1.274e-38	166.0	COG0505@1|root,COG0505@2|Bacteria,2GM9I@201174|Actinobacteria	201174|Actinobacteria	EF	Belongs to the CarA family	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1556538_0	656024.FsymDg_3317	2.019e-215	679.0	COG0044@1|root,COG0044@2|Bacteria,2GJ0T@201174|Actinobacteria,4ERCY@85013|Frankiales	201174|Actinobacteria	F	Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily	pyrC	GO:0003674,GO:0003824,GO:0004038,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006144,GO:0006145,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009112,GO:0009987,GO:0016787,GO:0016810,GO:0016812,GO:0019439,GO:0034641,GO:0040007,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044424,GO:0044464,GO:0046113,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
HKD2_k127_1556538_1	710111.FraQA3DRAFT_6297	3.801e-159	517.0	COG0540@1|root,COG0540@2|Bacteria,2GKNA@201174|Actinobacteria,4ES0C@85013|Frankiales	201174|Actinobacteria	F	Belongs to the ATCase OTCase family	pyrB	GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
HKD2_k127_1556538_3	106370.Francci3_3203	7.918e-87	293.0	COG2065@1|root,COG2065@2|Bacteria,2GJNP@201174|Actinobacteria,4ESJQ@85013|Frankiales	201174|Actinobacteria	F	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant	pyrR	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	2.4.2.9	ko:K02825	ko00240,ko01100,map00240,map01100	-	R00966	RC00063	ko00000,ko00001,ko01000,ko03000	-	-	-	Pribosyltran
HKD2_k127_1556538_2	298654.FraEuI1c_1676	1.527e-88	294.0	COG1396@1|root,COG1396@2|Bacteria,2I569@201174|Actinobacteria,4ESCS@85013|Frankiales	201174|Actinobacteria	K	PFAM helix-turn-helix domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3,HTH_31
HKD2_k127_1556538_4	1283283.ATXA01000002_gene2600	1.547e-46	175.0	COG0781@1|root,COG0781@2|Bacteria,2IM3D@201174|Actinobacteria,4ESRS@85013|Frankiales	201174|Actinobacteria	K	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons	nusB	GO:0008150,GO:0040007	-	ko:K03625	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	NusB
HKD2_k127_1556538_6	298655.KI912267_gene7558	3.467e-26	107.0	COG0231@1|root,COG0231@2|Bacteria,2GJMS@201174|Actinobacteria,4ERK9@85013|Frankiales	201174|Actinobacteria	J	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase	efp	GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K02356	-	-	-	-	ko00000,ko03012	-	-	-	EFP,EFP_N,Elong-fact-P_C
HKD2_k127_1570329_0	222534.KB893783_gene5233	1.732e-129	423.0	COG0861@1|root,COG0861@2|Bacteria,2GIWU@201174|Actinobacteria,4ES61@85013|Frankiales	201174|Actinobacteria	P	PFAM Integral membrane protein TerC	-	-	-	ko:K05794	-	-	-	-	ko00000	-	-	-	TerC
HKD2_k127_1570329_1	1429046.RR21198_3350	3.292e-45	179.0	COG0517@1|root,COG1994@1|root,COG0517@2|Bacteria,COG1994@2|Bacteria,2GJBZ@201174|Actinobacteria,4FWTB@85025|Nocardiaceae	201174|Actinobacteria	S	Peptidase family M50	-	-	-	-	-	-	-	-	-	-	-	-	CBS,Peptidase_M50
HKD2_k127_1570329_3	1123320.KB889563_gene6537	1.835e-18	92.0	COG0517@1|root,COG0517@2|Bacteria,2GQ8D@201174|Actinobacteria	201174|Actinobacteria	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
HKD2_k127_1570329_4	290399.Arth_0396	2.932e-16	90.0	COG0589@1|root,COG0589@2|Bacteria,2IQPQ@201174|Actinobacteria,1WBI7@1268|Micrococcaceae	201174|Actinobacteria	T	Belongs to the universal stress protein A family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD2_k127_1570329_2	1121926.AXWO01000020_gene2027	3.249e-26	114.0	COG0589@1|root,COG0589@2|Bacteria,2IQPQ@201174|Actinobacteria,4F0C4@85014|Glycomycetales	201174|Actinobacteria	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD2_k127_1570329_5	68223.JNZY01000025_gene6282	4.39e-05	46.0	COG0778@1|root,COG0778@2|Bacteria,2I8P3@201174|Actinobacteria	201174|Actinobacteria	C	Nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
HKD2_k127_158098_3	656024.FsymDg_4079	3.146e-73	248.0	COG0667@1|root,COG0667@2|Bacteria,2GMNA@201174|Actinobacteria,4ES2N@85013|Frankiales	201174|Actinobacteria	C	PFAM aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
HKD2_k127_158098_8	1089455.MOPEL_005_00230	1.303e-59	222.0	COG1073@1|root,COG1073@2|Bacteria,2I2F1@201174|Actinobacteria,4F7VA@85018|Dermatophilaceae	201174|Actinobacteria	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6,Hydrolase_4
HKD2_k127_158098_9	222534.KB893724_gene429	1.137e-05	57.0	COG2847@1|root,COG2847@2|Bacteria,2ISZB@201174|Actinobacteria,4ETHN@85013|Frankiales	201174|Actinobacteria	S	Copper chaperone PCu(A)C	-	-	-	-	-	-	-	-	-	-	-	-	PCuAC
HKD2_k127_158098_2	656024.FsymDg_1765	7.865e-124	418.0	COG3004@1|root,COG3004@2|Bacteria,2GKIK@201174|Actinobacteria,4ERNX@85013|Frankiales	201174|Actinobacteria	P	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons	nhaA	-	-	ko:K03313	-	-	-	-	ko00000,ko02000	2.A.33.1	-	-	Na_H_antiport_1
HKD2_k127_158098_4	1206725.BAFU01000061_gene431	1.247e-72	248.0	COG2110@1|root,COG2110@2|Bacteria,2IFEC@201174|Actinobacteria,4G0QP@85025|Nocardiaceae	201174|Actinobacteria	S	Appr-1'-p processing enzyme	lppD	GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Macro
HKD2_k127_158098_5	710111.FraQA3DRAFT_5464	8.504e-70	249.0	COG3550@1|root,COG3550@2|Bacteria,2I2QD@201174|Actinobacteria	201174|Actinobacteria	S	MDMPI C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	MDMPI_C,MDMPI_N
HKD2_k127_158098_0	656024.FsymDg_4081	9.31e-182	590.0	COG0438@1|root,COG0438@2|Bacteria,2GJ57@201174|Actinobacteria,4ES4V@85013|Frankiales	201174|Actinobacteria	M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway	mshA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0008150,GO:0008152,GO:0008194,GO:0008375,GO:0009058,GO:0009987,GO:0010125,GO:0010126,GO:0016137,GO:0016138,GO:0016740,GO:0016757,GO:0016758,GO:0044237,GO:0044249,GO:0044272,GO:0044424,GO:0044444,GO:0044464,GO:0051186,GO:0051188,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1901657,GO:1901659	2.4.1.250	ko:K15521	-	-	-	-	ko00000,ko01000	-	-	-	Glyco_transf_4,Glycos_transf_1
HKD2_k127_158098_6	710111.FraQA3DRAFT_4004	1.539e-69	240.0	2AZ39@1|root,31R9K@2|Bacteria,2GMCY@201174|Actinobacteria,4ESU9@85013|Frankiales	201174|Actinobacteria	S	Putative bacterial sensory transduction regulator	-	-	-	-	-	-	-	-	-	-	-	-	YbjN
HKD2_k127_158098_1	656024.FsymDg_4069	6.218e-136	436.0	COG0588@1|root,COG0588@2|Bacteria,2GK8F@201174|Actinobacteria,4ERI8@85013|Frankiales	201174|Actinobacteria	G	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate	gpmA	GO:0003674,GO:0003824,GO:0004619,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005996,GO:0006006,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006109,GO:0006139,GO:0006140,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009894,GO:0009987,GO:0010675,GO:0016020,GO:0016043,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0018130,GO:0019219,GO:0019220,GO:0019222,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0022607,GO:0031323,GO:0031329,GO:0032787,GO:0032991,GO:0034248,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042802,GO:0042866,GO:0043436,GO:0043455,GO:0043456,GO:0043470,GO:0043471,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046538,GO:0046700,GO:0046939,GO:0050789,GO:0050794,GO:0051171,GO:0051174,GO:0051186,GO:0051188,GO:0051193,GO:0051196,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055086,GO:0060255,GO:0062012,GO:0065003,GO:0065007,GO:0071704,GO:0071840,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0080090,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1902031	5.4.2.11	ko:K01834	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	His_Phos_1
HKD2_k127_158098_7	298653.Franean1_6147	2.42e-65	224.0	COG0704@1|root,COG0704@2|Bacteria,2GKAD@201174|Actinobacteria,4ESDP@85013|Frankiales	201174|Actinobacteria	P	Plays a role in the regulation of phosphate uptake	phoU	-	-	ko:K02039	-	-	-	-	ko00000	-	-	-	PhoU
HKD2_k127_1622635_0	365528.KB891208_gene2982	2.72e-277	857.0	COG1217@1|root,COG1217@2|Bacteria,2GJUJ@201174|Actinobacteria,4ES8A@85013|Frankiales	201174|Actinobacteria	T	GTP-binding protein TypA	typA	-	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2
HKD2_k127_1622635_1	196162.Noca_4421	0.0004679	46.0	2DBEB@1|root,32TXC@2|Bacteria,2IRDQ@201174|Actinobacteria,4DRKW@85009|Propionibacteriales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1668112_1	1150398.JIBJ01000014_gene2436	1.996e-76	261.0	COG0707@1|root,COG0707@2|Bacteria,2GJEM@201174|Actinobacteria,1W7R5@1268|Micrococcaceae	201174|Actinobacteria	M	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)	murG	-	2.4.1.227,6.3.2.8	ko:K01924,ko:K02563	ko00471,ko00550,ko01100,ko01502,ko04112,map00471,map00550,map01100,map01502,map04112	-	R03193,R05032,R05662	RC00005,RC00049,RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	GT28	-	Glyco_tran_28_C,Glyco_transf_28
HKD2_k127_1668112_0	1077972.ARGLB_051_01170	9.235e-193	611.0	COG0773@1|root,COG0773@2|Bacteria,2I2E7@201174|Actinobacteria,1W7MP@1268|Micrococcaceae	201174|Actinobacteria	M	Belongs to the MurCDEF family	murC	-	6.3.2.8	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R03193	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
HKD2_k127_1712345_2	1120949.KB903305_gene7116	6.431e-83	290.0	28HWT@1|root,2Z82P@2|Bacteria,2IJH8@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1712345_6	543632.JOJL01000018_gene9074	1.184e-45	184.0	COG3764@1|root,COG3764@2|Bacteria,2I91T@201174|Actinobacteria,4DE2Q@85008|Micromonosporales	201174|Actinobacteria	M	Sortase family	-	-	-	-	-	-	-	-	-	-	-	-	Sortase
HKD2_k127_1712345_5	365528.KB891208_gene2821	9.424e-47	185.0	COG0212@1|root,COG0212@2|Bacteria,2IKWR@201174|Actinobacteria,4ETE1@85013|Frankiales	201174|Actinobacteria	H	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family	ygfA	-	6.3.3.2	ko:K01934	ko00670,ko01100,map00670,map01100	-	R02301	RC00183	ko00000,ko00001,ko01000	-	-	-	5-FTHF_cyc-lig
HKD2_k127_1712345_0	298654.FraEuI1c_0541	3.931e-150	479.0	COG1210@1|root,COG1210@2|Bacteria,2I2EW@201174|Actinobacteria,4ERV7@85013|Frankiales	201174|Actinobacteria	M	UTP-glucose-1-phosphate uridylyltransferase	galU	-	2.7.7.9	ko:K00963	ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130	M00129,M00361,M00362,M00549	R00289	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
HKD2_k127_1712345_1	710111.FraQA3DRAFT_5329	1.434e-140	459.0	COG0303@1|root,COG0303@2|Bacteria,2GJC3@201174|Actinobacteria,4ERWC@85013|Frankiales	201174|Actinobacteria	H	MoeA domain protein domain I and II	moeA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006163,GO:0006464,GO:0006725,GO:0006732,GO:0006753,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009144,GO:0009150,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0018315,GO:0019538,GO:0019637,GO:0019693,GO:0019720,GO:0032324,GO:0034641,GO:0036211,GO:0042040,GO:0042278,GO:0043170,GO:0043412,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046039,GO:0046128,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0055086,GO:0061598,GO:0061599,GO:0070566,GO:0071704,GO:0071944,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657	2.10.1.1,2.7.7.9	ko:K00963,ko:K03750	ko00040,ko00052,ko00500,ko00520,ko00790,ko01100,ko01130,map00040,map00052,map00500,map00520,map00790,map01100,map01130	M00129,M00361,M00362,M00549	R00289,R09735	RC00002,RC03462	ko00000,ko00001,ko00002,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N
HKD2_k127_1712345_3	656024.FsymDg_4133	3.769e-60	226.0	COG0315@1|root,COG0315@2|Bacteria,2IHR6@201174|Actinobacteria,4ESM0@85013|Frankiales	201174|Actinobacteria	H	Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)	moaC	-	4.6.1.17	ko:K03637	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R11372	RC03425	ko00000,ko00001,ko01000	-	-	-	MoaC
HKD2_k127_1712345_4	298655.KI912266_gene1786	1.942e-57	205.0	COG0521@1|root,COG0521@2|Bacteria,2II28@201174|Actinobacteria,4ESU1@85013|Frankiales	201174|Actinobacteria	H	TIGRFAM molybdenum cofactor synthesis domain	mog	-	2.8.1.12	ko:K03635	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09395	RC02507	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoaE
HKD2_k127_1712345_7	656024.FsymDg_4135	2.03e-14	83.0	COG1670@1|root,COG1670@2|Bacteria,2HAFI@201174|Actinobacteria,4ESJY@85013|Frankiales	201174|Actinobacteria	J	PFAM GCN5-related N-acetyltransferase	rimJ	-	2.3.1.128	ko:K03790	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_3
HKD2_k127_1733434_1	1123065.ATWL01000005_gene1246	1.635e-11	70.0	2BSTJ@1|root,32MX0@2|Bacteria,2GY5J@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1733434_0	298653.Franean1_1095	2.311e-293	909.0	COG0119@1|root,COG0119@2|Bacteria,2GISX@201174|Actinobacteria,4ERVK@85013|Frankiales	201174|Actinobacteria	E	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)	leuA	GO:0000287,GO:0003674,GO:0003824,GO:0003852,GO:0005488,GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016746,GO:0019752,GO:0030145,GO:0030955,GO:0031420,GO:0040007,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046872,GO:0046912,GO:0046914,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
HKD2_k127_1783804_1	106370.Francci3_3642	8.493e-248	779.0	COG0064@1|root,COG0064@2|Bacteria,2GJJH@201174|Actinobacteria,4ES0M@85013|Frankiales	201174|Actinobacteria	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatB	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	GatB_N,GatB_Yqey
HKD2_k127_1783804_6	562970.Btus_2958	7.884e-12	68.0	COG1598@1|root,COG1598@2|Bacteria,1VHTY@1239|Firmicutes	1239|Firmicutes	S	PFAM Uncharacterised protein family UPF0150	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1783804_0	656024.FsymDg_3770	3.405e-256	799.0	COG0154@1|root,COG0154@2|Bacteria,2GJK5@201174|Actinobacteria,4ES8T@85013|Frankiales	201174|Actinobacteria	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	GO:0008150,GO:0040007	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
HKD2_k127_1783804_5	222534.KB893794_gene2451	3.092e-41	159.0	COG0721@1|root,COG0721@2|Bacteria,2IQJN@201174|Actinobacteria,4ESZM@85013|Frankiales	201174|Actinobacteria	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatC	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	6.3.5.6,6.3.5.7	ko:K02435	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Glu-tRNAGln
HKD2_k127_1783804_3	1449976.KALB_7945	2.716e-67	252.0	COG1595@1|root,COG1595@2|Bacteria,2GJFK@201174|Actinobacteria,4E0JT@85010|Pseudonocardiales	201174|Actinobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2,zf-HC2
HKD2_k127_1783804_2	710111.FraQA3DRAFT_5738	5.658e-87	293.0	COG0317@1|root,COG0317@2|Bacteria,2GNRE@201174|Actinobacteria,4ESY2@85013|Frankiales	201174|Actinobacteria	KT	PFAM amino acid-binding ACT domain protein	-	-	-	-	-	-	-	-	-	-	-	-	ACT
HKD2_k127_1783804_4	298653.Franean1_1083	1.238e-62	230.0	COG5001@1|root,COG5001@2|Bacteria,2GIZF@201174|Actinobacteria,4ERVM@85013|Frankiales	201174|Actinobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF
HKD2_k127_1804754_5	1306174.JODP01000016_gene7151	2.089e-87	309.0	COG0842@1|root,COG0842@2|Bacteria,2GJGH@201174|Actinobacteria	201174|Actinobacteria	V	transport, permease protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
HKD2_k127_1804754_3	1306174.JODP01000016_gene7152	2.11e-132	429.0	COG1131@1|root,COG1131@2|Bacteria,2GKI7@201174|Actinobacteria	201174|Actinobacteria	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
HKD2_k127_1804754_7	479435.Kfla_6306	8.315e-52	190.0	COG1695@1|root,COG1695@2|Bacteria,2GKHU@201174|Actinobacteria,4DQDR@85009|Propionibacteriales	201174|Actinobacteria	K	Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	PadR
HKD2_k127_1804754_0	656024.FsymDg_0253	2.544e-238	745.0	COG0372@1|root,COG0372@2|Bacteria,2GJ7E@201174|Actinobacteria,4ESB0@85013|Frankiales	201174|Actinobacteria	C	Belongs to the citrate synthase family	gltA	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
HKD2_k127_1804754_4	1146883.BLASA_1987	3.42e-109	370.0	COG1289@1|root,COG2267@1|root,COG1289@2|Bacteria,COG2267@2|Bacteria,2GMCK@201174|Actinobacteria,4ESNI@85013|Frankiales	201174|Actinobacteria	I	PFAM Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_4,Abhydrolase_6,Hydrolase_4
HKD2_k127_1804754_1	383372.Rcas_0084	1.064e-162	519.0	COG0667@1|root,COG0667@2|Bacteria,2G5V3@200795|Chloroflexi,377XZ@32061|Chloroflexia	32061|Chloroflexia	C	PFAM aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
HKD2_k127_1804754_8	1449353.JQMQ01000005_gene2680	2.438e-44	168.0	COG1514@1|root,COG1514@2|Bacteria,2GNDN@201174|Actinobacteria,2NI5K@228398|Streptacidiphilus	201174|Actinobacteria	J	2'-5' RNA ligase superfamily	ligT	-	3.1.4.58	ko:K01975	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	LigT_PEase
HKD2_k127_1804754_9	479432.Sros_2013	4.803e-36	144.0	COG2402@1|root,COG2402@2|Bacteria,2IRQ5@201174|Actinobacteria	201174|Actinobacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	ko:K07065	-	-	-	-	ko00000	-	-	-	PIN
HKD2_k127_1804754_2	656024.FsymDg_1896	9.629e-154	509.0	COG0168@1|root,COG0168@2|Bacteria,2GKKS@201174|Actinobacteria,4EUF3@85013|Frankiales	201174|Actinobacteria	P	Cation transport protein	ktrB	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
HKD2_k127_1804754_6	1185652.USDA257_c26780	1.762e-60	213.0	COG0569@1|root,COG0569@2|Bacteria,1R7KM@1224|Proteobacteria,2TY5D@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	COG0569 K transport systems, NAD-binding component	-	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
HKD2_k127_181953_0	369723.Strop_4258	1.257e-152	490.0	COG3508@1|root,COG3508@2|Bacteria,2GKZV@201174|Actinobacteria,4DA7H@85008|Micromonosporales	201174|Actinobacteria	Q	homogentisate 12-dioxygenase	hmgA	-	1.13.11.5	ko:K00451	ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120	M00044	R02519	RC00737	ko00000,ko00001,ko00002,ko01000	-	-	-	HgmA
HKD2_k127_181953_2	1048339.KB913029_gene972	3.683e-113	386.0	COG0491@1|root,COG0491@2|Bacteria,2HTU1@201174|Actinobacteria,4EUGY@85013|Frankiales	201174|Actinobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HKD2_k127_181953_1	1394178.AWOO02000074_gene2251	2.83e-126	432.0	COG0654@1|root,COG0654@2|Bacteria,2GKIN@201174|Actinobacteria,4EHV7@85012|Streptosporangiales	201174|Actinobacteria	CH	FAD binding domain	-	-	1.14.13.127	ko:K05712	ko00360,ko01120,ko01220,map00360,map01120,map01220	M00545	R06786,R06787	RC00236	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_3
HKD2_k127_1834965_11	222534.KB893737_gene729	3.528e-06	56.0	COG4585@1|root,COG4585@2|Bacteria,2GRPP@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase-like ATPases	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c
HKD2_k127_1834965_2	656024.FsymDg_3136	4.506e-136	443.0	COG3842@1|root,COG3842@2|Bacteria,2H2JF@201174|Actinobacteria,4ERHP@85013|Frankiales	201174|Actinobacteria	P	TOBE domain	modC	-	3.6.3.29	ko:K02017,ko:K02018	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.8	-	-	ABC_tran,TOBE
HKD2_k127_1834965_5	656024.FsymDg_3137	2.088e-110	380.0	COG4149@1|root,COG4149@2|Bacteria,2GJFB@201174|Actinobacteria,4ESD6@85013|Frankiales	201174|Actinobacteria	P	PFAM binding-protein-dependent transport systems inner membrane component	modB	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	3.6.3.29	ko:K02017,ko:K02018	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.8	-	-	ABC_tran,BPD_transp_1,TOBE
HKD2_k127_1834965_9	656024.FsymDg_1458	1.316e-81	280.0	COG0725@1|root,COG0725@2|Bacteria,2GMPF@201174|Actinobacteria,4ESN3@85013|Frankiales	201174|Actinobacteria	P	TIGRFAM molybdenum ABC transporter, periplasmic molybdate-binding protein	modA	-	-	ko:K02020	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.8	-	-	SBP_bac_11
HKD2_k127_1834965_3	1123322.KB904699_gene4621	6.117e-127	416.0	COG2843@1|root,COG2843@2|Bacteria,2GK15@201174|Actinobacteria	201174|Actinobacteria	M	Capsule synthesis protein	-	-	-	ko:K07282	-	-	-	-	ko00000	-	-	-	PGA_cap
HKD2_k127_1834965_1	656024.FsymDg_0730	7.134e-230	721.0	COG1928@1|root,COG1928@2|Bacteria,2I2H1@201174|Actinobacteria,4ERJX@85013|Frankiales	201174|Actinobacteria	O	PFAM glycosyl transferase family 39	pmt	-	2.4.1.109	ko:K00728	ko00514,ko00515,ko01100,map00514,map00515,map01100	-	R04072,R07620,R11399	RC00005,RC00059,RC00397	ko00000,ko00001,ko01000,ko01003	-	GT39	-	PMT,PMT_4TMC
HKD2_k127_1834965_6	656024.FsymDg_0731	3.584e-103	344.0	COG0313@1|root,COG0313@2|Bacteria,2GJ9Q@201174|Actinobacteria,4ERK3@85013|Frankiales	201174|Actinobacteria	H	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA	rsmI	GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016072,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:1901360	2.1.1.198	ko:K07056	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TP_methylase
HKD2_k127_1834965_0	469371.Tbis_3171	8.783e-240	761.0	COG0143@1|root,COG0143@2|Bacteria,2GK4S@201174|Actinobacteria,4E07J@85010|Pseudonocardiales	201174|Actinobacteria	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	GO:0003674,GO:0003824,GO:0004812,GO:0004825,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006431,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g
HKD2_k127_1834965_8	469383.Cwoe_5385	9.998e-87	304.0	COG1808@1|root,COG1808@2|Bacteria,2GJQ4@201174|Actinobacteria,4CRP3@84995|Rubrobacteria	84995|Rubrobacteria	S	Domain of unknown function (DUF389)	-	-	-	-	-	-	-	-	-	-	-	-	DUF389
HKD2_k127_1834965_10	345341.KUTG_05349	9.874e-36	153.0	COG1832@1|root,COG1832@2|Bacteria,2IHSP@201174|Actinobacteria,4E51X@85010|Pseudonocardiales	201174|Actinobacteria	S	CoA binding domain	-	-	-	ko:K06929	-	-	-	-	ko00000	-	-	-	CoA_binding_2
HKD2_k127_1834965_4	298655.KI912266_gene1827	1.612e-118	387.0	COG0084@1|root,COG0084@2|Bacteria,2GMJJ@201174|Actinobacteria,4ES85@85013|Frankiales	201174|Actinobacteria	L	TIGRFAM hydrolase, TatD family	tatD	GO:0003674,GO:0003824,GO:0004518,GO:0004536,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016020,GO:0016787,GO:0016788,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0071944,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901361,GO:1901575	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
HKD2_k127_1834965_7	656024.FsymDg_0735	2.071e-93	322.0	COG0030@1|root,COG0030@2|Bacteria,2GKBT@201174|Actinobacteria,4ES96@85013|Frankiales	201174|Actinobacteria	J	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
HKD2_k127_1842781_1	106370.Francci3_3168	4.735e-74	251.0	COG0165@1|root,COG0165@2|Bacteria,2GJ2A@201174|Actinobacteria,4ES14@85013|Frankiales	201174|Actinobacteria	E	argininosuccinate lyase	argH	GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0030312,GO:0040007,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.3.2.1	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01086	RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ASL_C2,Lyase_1
HKD2_k127_1842781_2	298654.FraEuI1c_1719	3.382e-72	256.0	COG2094@1|root,COG2094@2|Bacteria,2GNW1@201174|Actinobacteria,4ESPH@85013|Frankiales	201174|Actinobacteria	L	Belongs to the DNA glycosylase MPG family	alkA	GO:0003674,GO:0003824,GO:0003905,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360	3.2.2.21	ko:K03652	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Pur_DNA_glyco
HKD2_k127_1842781_0	471852.Tcur_2160	2.458e-108	369.0	COG0162@1|root,COG0162@2|Bacteria,2GJPR@201174|Actinobacteria,4EFWJ@85012|Streptosporangiales	201174|Actinobacteria	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	GO:0003674,GO:0003824,GO:0004812,GO:0004831,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019752,GO:0030312,GO:0034641,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	S4,tRNA-synt_1b
HKD2_k127_184731_2	106370.Francci3_0533	3.054e-155	500.0	COG1060@1|root,COG1060@2|Bacteria,2GK83@201174|Actinobacteria,4EUYV@85013|Frankiales	201174|Actinobacteria	H	Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2)	mqnC	GO:0003674,GO:0003824,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016740,GO:0016765,GO:0044237,GO:0044249,GO:0044689,GO:0051186,GO:0051188	1.21.98.1,2.5.1.77	ko:K11779,ko:K11784	ko00130,ko00680,ko01110,ko01120,map00130,map00680,map01110,map01120	M00378	R08588,R09396	RC01381,RC02329,RC03002,RC03007	ko00000,ko00001,ko00002,ko01000	-	-	-	Radical_SAM
HKD2_k127_184731_1	710111.FraQA3DRAFT_3935	4.386e-162	523.0	COG0492@1|root,COG0492@2|Bacteria,2GJ1Z@201174|Actinobacteria,4ERYC@85013|Frankiales	201174|Actinobacteria	C	Ferredoxin--NADP reductase	-	-	1.18.1.2,1.19.1.1	ko:K21567	-	-	-	-	ko00000,ko01000	-	-	-	Pyr_redox_2
HKD2_k127_184731_5	298655.KI912266_gene383	1.323e-41	159.0	COG2138@1|root,COG2138@2|Bacteria	2|Bacteria	S	sirohydrochlorin cobaltochelatase activity	-	-	4.99.1.3,5.4.99.60,5.4.99.61	ko:K03795,ko:K06042	ko00860,ko01100,ko01120,map00860,map01100,map01120	-	R05177,R05807,R05814	RC01012,RC01292,RC01980	ko00000,ko00001,ko01000	-	-	-	CbiC,CbiX
HKD2_k127_184731_4	1123320.KB889607_gene9658	8.845e-51	191.0	2FBFZ@1|root,343MC@2|Bacteria,2H8HK@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_184731_7	1348663.KCH_20090	2.624e-10	73.0	COG3677@1|root,COG3677@2|Bacteria,2GQKE@201174|Actinobacteria,2M3VR@2063|Kitasatospora	201174|Actinobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_184731_0	656024.FsymDg_4018	1.884e-281	873.0	COG0155@1|root,COG0155@2|Bacteria,2GJRN@201174|Actinobacteria,4ES1T@85013|Frankiales	201174|Actinobacteria	C	nitrite sulfite reductase, hemoprotein beta-component, ferrodoxin domain protein	sir	GO:0000096,GO:0000097,GO:0000103,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016002,GO:0016053,GO:0016491,GO:0016667,GO:0016673,GO:0019344,GO:0019752,GO:0030312,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0048037,GO:0050311,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.7.7.1,1.8.7.1	ko:K00366,ko:K00392	ko00910,ko00920,ko01100,ko01120,map00910,map00920,map01100,map01120	M00176,M00531	R00790,R00859,R03600	RC00065,RC00176	ko00000,ko00001,ko00002,ko01000	-	-	-	NIR_SIR,NIR_SIR_ferr
HKD2_k127_184731_6	656024.FsymDg_4020	2.415e-40	163.0	COG2197@1|root,COG2197@2|Bacteria,2IB5N@201174|Actinobacteria,4EW6H@85013|Frankiales	201174|Actinobacteria	T	Response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg
HKD2_k127_184731_3	298653.Franean1_6108	4.299e-76	258.0	COG1427@1|root,COG1427@2|Bacteria,2GJGY@201174|Actinobacteria	201174|Actinobacteria	S	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)	mqnA	-	4.2.1.151	ko:K11782	ko00130,ko01110,map00130,map01110	-	R10666	RC03232	ko00000,ko00001,ko01000	-	-	-	VitK2_biosynth
HKD2_k127_1875515_5	106370.Francci3_0775	2.132e-28	125.0	COG1752@1|root,COG1752@2|Bacteria,2IB0F@201174|Actinobacteria,4ET56@85013|Frankiales	201174|Actinobacteria	S	Patatin-like phospholipase	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
HKD2_k127_1875515_0	211114.JOEF01000001_gene7368	2.01e-187	596.0	COG1020@1|root,COG1020@2|Bacteria,2HEFF@201174|Actinobacteria,4DZCT@85010|Pseudonocardiales	201174|Actinobacteria	Q	Belongs to the long-chain O-acyltransferase family	tgs3	GO:0000302,GO:0001666,GO:0003674,GO:0003824,GO:0004144,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006629,GO:0006638,GO:0006639,GO:0006641,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008374,GO:0008610,GO:0009058,GO:0009628,GO:0009987,GO:0010035,GO:0016020,GO:0016411,GO:0016740,GO:0016746,GO:0016747,GO:0019432,GO:0030312,GO:0036293,GO:0040007,GO:0042221,GO:0042493,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044403,GO:0044419,GO:0044464,GO:0045017,GO:0046460,GO:0046463,GO:0046486,GO:0047196,GO:0050896,GO:0051704,GO:0070482,GO:0071704,GO:0071731,GO:0071944,GO:0097366,GO:1901576,GO:1901698,GO:1901700	2.3.1.20	ko:K00635	ko00561,ko01100,map00561,map01100	M00089	R02251	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF1298,WES_acyltransf
HKD2_k127_1875515_1	326424.FRAAL1312	1.507e-86	294.0	COG0455@1|root,COG0455@2|Bacteria,2IARP@201174|Actinobacteria,4ERDT@85013|Frankiales	201174|Actinobacteria	D	bacterial-type flagellum organization	-	-	-	-	-	-	-	-	-	-	-	-	CbiA
HKD2_k127_1875515_8	452863.Achl_2431	9.612e-23	110.0	COG0455@1|root,COG0455@2|Bacteria,2IARP@201174|Actinobacteria,1W8IX@1268|Micrococcaceae	201174|Actinobacteria	D	CobQ/CobB/MinD/ParA nucleotide binding domain	-	-	-	-	-	-	-	-	-	-	-	-	CbiA
HKD2_k127_1875515_4	656024.FsymDg_1112	2.823e-32	129.0	COG3311@1|root,COG3311@2|Bacteria,2GR98@201174|Actinobacteria,4ETBQ@85013|Frankiales	201174|Actinobacteria	K	excisionase family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_17
HKD2_k127_1875515_3	656024.FsymDg_1111	1.2e-53	202.0	2E4C6@1|root,32Z7Q@2|Bacteria,2GRH1@201174|Actinobacteria,4ETFH@85013|Frankiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1875515_6	656024.FsymDg_1110	7.552e-28	124.0	COG1652@1|root,COG1652@2|Bacteria,2GQMU@201174|Actinobacteria,4ETKP@85013|Frankiales	201174|Actinobacteria	S	PFAM Peptidoglycan-binding lysin domain	-	-	-	-	-	-	-	-	-	-	-	-	LysM
HKD2_k127_1875515_9	1122622.ATWJ01000015_gene642	8.934e-20	100.0	COG1652@1|root,COG1652@2|Bacteria,2GQMU@201174|Actinobacteria,4FH7Q@85021|Intrasporangiaceae	201174|Actinobacteria	S	PFAM Peptidoglycan-binding lysin domain	-	-	-	-	-	-	-	-	-	-	-	-	LysM
HKD2_k127_1875515_7	656024.FsymDg_1109	3.817e-25	117.0	2DPN9@1|root,332RH@2|Bacteria,2GXBG@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1899425_2	298655.KI912266_gene400	0.0002281	52.0	COG0755@1|root,COG0755@2|Bacteria,2GJR1@201174|Actinobacteria,4ESE9@85013|Frankiales	201174|Actinobacteria	O	Cytochrome c-type biogenesis protein	ccsB	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C_asm
HKD2_k127_1899425_0	656024.FsymDg_4032	3.763e-230	725.0	COG1333@1|root,COG1333@2|Bacteria,2GMGH@201174|Actinobacteria,4ERPQ@85013|Frankiales	201174|Actinobacteria	O	PFAM ResB family protein	resB	-	-	ko:K07399	-	-	-	-	ko00000	-	-	-	ResB
HKD2_k127_1899425_1	656024.FsymDg_4033	1.381e-82	278.0	COG0785@1|root,COG0785@2|Bacteria,2GJW3@201174|Actinobacteria,4ESK1@85013|Frankiales	201174|Actinobacteria	O	cytochrome c biogenesis protein	ccdA	-	-	ko:K06196	-	-	-	-	ko00000,ko02000	5.A.1.2	-	-	DsbD
HKD2_k127_1928318_1	1463885.KL578366_gene2788	4.056e-61	216.0	COG0745@1|root,COG0745@2|Bacteria,2GJE6@201174|Actinobacteria	201174|Actinobacteria	T	Response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
HKD2_k127_1928318_2	298653.Franean1_1612	6.071e-32	136.0	COG0745@1|root,COG0745@2|Bacteria,2GJE6@201174|Actinobacteria	201174|Actinobacteria	T	Response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
HKD2_k127_1928318_0	298653.Franean1_1613	1.635e-100	341.0	COG0642@1|root,COG2205@2|Bacteria,2I53J@201174|Actinobacteria,4EU80@85013|Frankiales	201174|Actinobacteria	T	histidine kinase HAMP region domain protein	-	-	2.7.13.3	ko:K07642	ko02020,map02020	M00450,M00645,M00646,M00648	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
HKD2_k127_1950278_0	298653.Franean1_0937	3.015e-87	294.0	COG1524@1|root,COG1524@2|Bacteria	2|Bacteria	S	mannose-ethanolamine phosphotransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	PE,Phosphodiest
HKD2_k127_1950278_1	298653.Franean1_0936	4.792e-40	156.0	2DMIS@1|root,32RVG@2|Bacteria,2IQ99@201174|Actinobacteria,4ET9I@85013|Frankiales	201174|Actinobacteria	K	Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA	whiB7	GO:0001101,GO:0008150,GO:0010033,GO:0033993,GO:0042221,GO:0046677,GO:0050896,GO:0070542,GO:1901700	-	ko:K18958	-	-	-	-	ko00000,ko03000	-	-	-	AT_hook,Whib
HKD2_k127_1950278_2	106370.Francci3_3792	5.468e-20	90.0	COG0210@1|root,COG0210@2|Bacteria,2GKRW@201174|Actinobacteria,4ES82@85013|Frankiales	201174|Actinobacteria	L	PFAM UvrD REP helicase	uvrD2	GO:0000287,GO:0003674,GO:0003678,GO:0003824,GO:0004386,GO:0005488,GO:0006996,GO:0008094,GO:0008150,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0040007,GO:0042623,GO:0043167,GO:0043169,GO:0046872,GO:0051276,GO:0071103,GO:0071840,GO:0140097	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HRDC,UvrD-helicase,UvrD_C
HKD2_k127_1951635_23	981369.JQMJ01000004_gene4865	1.8e-11	65.0	COG0677@1|root,COG0677@2|Bacteria,2GK5K@201174|Actinobacteria,2NENN@228398|Streptacidiphilus	201174|Actinobacteria	M	UDP binding domain	-	-	1.1.1.136,1.1.1.336	ko:K02472,ko:K13015	ko00520,ko05111,map00520,map05111	-	R00421,R03317	RC00291	ko00000,ko00001,ko01000,ko01005	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
HKD2_k127_1951635_19	408672.NBCG_05301	8.553e-24	114.0	COG3147@1|root,COG3147@2|Bacteria,2I8WA@201174|Actinobacteria	201174|Actinobacteria	N	Non-essential cell division protein that could be required for efficient cell constriction	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix
HKD2_k127_1951635_24	290399.Arth_4127	2.914e-05	55.0	2EDAP@1|root,33771@2|Bacteria,2GZW4@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1951635_22	1449353.JQMQ01000004_gene6008	2.76e-15	86.0	2CVZR@1|root,32SYR@2|Bacteria,2H2IQ@201174|Actinobacteria,2NFTY@228398|Streptacidiphilus	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Wzz
HKD2_k127_1951635_20	290399.Arth_4126	1.702e-17	89.0	COG3307@1|root,COG3307@2|Bacteria,2ICRB@201174|Actinobacteria	201174|Actinobacteria	M	PFAM O-antigen polymerase	-	-	-	-	-	-	-	-	-	-	-	-	Wzy_C
HKD2_k127_1951635_16	1108045.GORHZ_050_00020	2.939e-56	210.0	COG3307@1|root,COG3307@2|Bacteria,2ICRB@201174|Actinobacteria,4GDG6@85026|Gordoniaceae	201174|Actinobacteria	M	O-antigen ligase like membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	Wzy_C
HKD2_k127_1951635_8	1449353.JQMQ01000004_gene6001	3.271e-107	357.0	COG1215@1|root,COG1215@2|Bacteria,2HH5Q@201174|Actinobacteria,2NGJ4@228398|Streptacidiphilus	201174|Actinobacteria	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HKD2_k127_1951635_21	1828.JOKB01000066_gene4727	6.638e-17	93.0	COG0438@1|root,COG0438@2|Bacteria,2IEGK@201174|Actinobacteria,4G7CR@85025|Nocardiaceae	201174|Actinobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4
HKD2_k127_1951635_17	351607.Acel_1929	2.613e-51	192.0	COG0438@1|root,COG0438@2|Bacteria,2IEGK@201174|Actinobacteria,4EV6Z@85013|Frankiales	201174|Actinobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4
HKD2_k127_1951635_14	446462.Amir_1738	7.962e-72	264.0	COG0110@1|root,COG0110@2|Bacteria,2H5M0@201174|Actinobacteria,4DZYI@85010|Pseudonocardiales	201174|Actinobacteria	S	Bacterial transferase hexapeptide (six repeats)	-	-	-	-	-	-	-	-	-	-	-	-	FdtA,Hexapep,Hexapep_2,PP-binding
HKD2_k127_1951635_10	1380347.JNII01000006_gene1444	5.346e-102	341.0	COG0399@1|root,COG0399@2|Bacteria,2GKD7@201174|Actinobacteria,4EUKI@85013|Frankiales	201174|Actinobacteria	E	DegT/DnrJ/EryC1/StrS aminotransferase family	degT	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
HKD2_k127_1951635_18	1246995.AFR_15915	2.822e-34	134.0	COG0399@1|root,COG0399@2|Bacteria,2GKD7@201174|Actinobacteria,4DCEX@85008|Micromonosporales	201174|Actinobacteria	E	Belongs to the DegT DnrJ EryC1 family	degT	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
HKD2_k127_1951635_15	68194.JNXR01000010_gene5423	2.48e-71	265.0	COG0110@1|root,COG0110@2|Bacteria,2IDUP@201174|Actinobacteria	201174|Actinobacteria	GM	sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep,Hexapep_2
HKD2_k127_1951635_2	463191.SSEG_09307	1.051e-164	544.0	COG0399@1|root,COG0399@2|Bacteria,2GKD7@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the DegT DnrJ EryC1 family	-	-	2.6.1.102	ko:K13010	ko00520,map00520	-	R10460	RC00006,RC00781	ko00000,ko00001,ko01000,ko01005,ko01007	-	-	-	DegT_DnrJ_EryC1
HKD2_k127_1951635_6	68170.KL590493_gene6311	1.122e-127	419.0	COG0451@1|root,COG0451@2|Bacteria,2I2UT@201174|Actinobacteria,4E13V@85010|Pseudonocardiales	201174|Actinobacteria	M	Polysaccharide biosynthesis protein	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
HKD2_k127_1951635_4	285514.JNWO01000007_gene3858	9.316e-155	531.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
HKD2_k127_1951635_3	1463825.JNXC01000004_gene4324	3.105e-155	509.0	COG2372@1|root,COG3266@1|root,COG2372@2|Bacteria,COG3266@2|Bacteria,2I302@201174|Actinobacteria,4EF87@85010|Pseudonocardiales	201174|Actinobacteria	S	response to copper ion	-	-	-	-	-	-	-	-	-	-	-	-	Big_5,DUF4082
HKD2_k127_1951635_0	351607.Acel_1933	0.0	1043.0	COG1749@1|root,COG4257@1|root,COG1749@2|Bacteria,COG4257@2|Bacteria,2I2X3@201174|Actinobacteria,4EUDH@85013|Frankiales	201174|Actinobacteria	N	Bacterial Ig-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Big_5,DUF4082,Mo-co_dimer,fn3
HKD2_k127_1951635_9	306281.AJLK01000062_gene4972	8.569e-103	357.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4
HKD2_k127_1951635_7	1283283.ATXA01000018_gene4178	5.91e-108	372.0	COG2244@1|root,COG2244@2|Bacteria,2H55P@201174|Actinobacteria	201174|Actinobacteria	M	Polysaccharide biosynthesis protein	-	-	-	ko:K03328,ko:K16695	-	-	-	-	ko00000,ko02000	2.A.66.2,2.A.66.2.7	-	-	Polysacc_synt_3,Polysacc_synt_C
HKD2_k127_1951635_25	909613.UO65_5597	6.654e-05	53.0	COG2244@1|root,COG2244@2|Bacteria,2H55P@201174|Actinobacteria,4DY6N@85010|Pseudonocardiales	201174|Actinobacteria	S	Polysaccharide biosynthesis protein	-	-	-	ko:K03328,ko:K16695	-	-	-	-	ko00000,ko02000	2.A.66.2,2.A.66.2.7	-	-	Polysacc_synt_3,Polysacc_synt_C
HKD2_k127_1951635_11	106370.Francci3_3951	7.779e-85	299.0	COG0193@1|root,COG0193@2|Bacteria,2GKCV@201174|Actinobacteria,4ESK5@85013|Frankiales	201174|Actinobacteria	J	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis	pth	GO:0003674,GO:0003824,GO:0004045,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0016787,GO:0016788,GO:0040007,GO:0044464,GO:0052689,GO:0071944,GO:0140098,GO:0140101	3.1.1.29	ko:K01056	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	Pept_tRNA_hydro
HKD2_k127_1951635_13	656024.FsymDg_0744	6.57e-76	262.0	COG1825@1|root,COG1825@2|Bacteria,2GJPJ@201174|Actinobacteria,4ESJF@85013|Frankiales	201174|Actinobacteria	J	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance	ctc	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02897	ko03010,map03010	M00178	-	-	ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L25p,Ribosomal_TL5_C
HKD2_k127_1951635_5	526225.Gobs_0911	4.247e-150	500.0	COG0462@1|root,COG0462@2|Bacteria,2GJ9S@201174|Actinobacteria,4ERS5@85013|Frankiales	201174|Actinobacteria	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	prs	GO:0000287,GO:0003674,GO:0003824,GO:0004749,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006015,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016778,GO:0019637,GO:0019693,GO:0030145,GO:0030312,GO:0040007,GO:0043167,GO:0043169,GO:0044237,GO:0044464,GO:0046390,GO:0046391,GO:0046872,GO:0046914,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901576	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyl_synth,Pribosyltran_N
HKD2_k127_1951635_1	106370.Francci3_3961	3.614e-185	593.0	COG1207@1|root,COG1207@2|Bacteria,2GJS1@201174|Actinobacteria,4ERCR@85013|Frankiales	201174|Actinobacteria	M	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain	glmU	GO:0000287,GO:0003674,GO:0003824,GO:0003977,GO:0005488,GO:0008080,GO:0008150,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0016772,GO:0016779,GO:0019134,GO:0022610,GO:0030260,GO:0035635,GO:0040007,GO:0043167,GO:0043169,GO:0044403,GO:0044406,GO:0044409,GO:0044419,GO:0044650,GO:0046872,GO:0051701,GO:0051704,GO:0051806,GO:0051828,GO:0070569	2.3.1.157,2.7.7.23	ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transf_3,NTP_transferase
HKD2_k127_1951635_12	222534.KB893670_gene3828	2.722e-78	271.0	COG1398@1|root,COG1398@2|Bacteria,2GJJF@201174|Actinobacteria,4ES37@85013|Frankiales	201174|Actinobacteria	I	Fatty acid desaturase	-	-	1.14.19.1	ko:K00507	ko01040,ko01212,ko03320,ko04152,ko04212,map01040,map01212,map03320,map04152,map04212	-	R02222	RC00917	ko00000,ko00001,ko01000,ko01004	-	-	-	FA_desaturase
HKD2_k127_1960828_13	1121926.AXWO01000014_gene1810	5.913e-24	108.0	2E42V@1|root,32YZ9@2|Bacteria,2IG4T@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
HKD2_k127_1960828_7	1121926.AXWO01000014_gene1809	2.754e-75	259.0	COG2409@1|root,COG2409@2|Bacteria,2IH0P@201174|Actinobacteria	201174|Actinobacteria	S	Drug exporters of the RND superfamily	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1960828_2	266117.Rxyl_3194	2.601e-202	638.0	COG1012@1|root,COG1012@2|Bacteria,2GIWZ@201174|Actinobacteria,4CPFP@84995|Rubrobacteria	84995|Rubrobacteria	C	Belongs to the aldehyde dehydrogenase family	-	-	1.2.1.8	ko:K00130	ko00260,ko01100,map00260,map01100	M00555	R02565,R02566	RC00080	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
HKD2_k127_1960828_3	710111.FraQA3DRAFT_0360	2.025e-178	563.0	COG2308@1|root,COG2308@2|Bacteria,2GN0J@201174|Actinobacteria,4ES9X@85013|Frankiales	201174|Actinobacteria	S	Circularly permuted ATP-grasp type 2	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-E,CP_ATPgrasp_1,CP_ATPgrasp_2
HKD2_k127_1960828_9	494419.ALPM01000063_gene2192	6.247e-42	173.0	COG2308@1|root,COG2308@2|Bacteria,2GN0J@201174|Actinobacteria,1W7QA@1268|Micrococcaceae	201174|Actinobacteria	S	Circularly permuted ATP-grasp type 2	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-E,CP_ATPgrasp_1,CP_ATPgrasp_2
HKD2_k127_1960828_4	656024.FsymDg_1743	3.547e-151	487.0	COG2307@1|root,COG2307@2|Bacteria,2GN0T@201174|Actinobacteria,4ERUV@85013|Frankiales	201174|Actinobacteria	S	A predicted alpha-helical domain with a conserved ER motif.	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-E
HKD2_k127_1960828_5	656024.FsymDg_1741	1.585e-129	425.0	COG1305@1|root,COG1305@2|Bacteria,2GN5D@201174|Actinobacteria,4ESH4@85013|Frankiales	201174|Actinobacteria	E	Bacterial transglutaminase-like N-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	Bact_transglu_N,Transglut_core
HKD2_k127_1960828_12	656024.FsymDg_3099	1.192e-31	127.0	COG4118@1|root,COG4118@2|Bacteria	2|Bacteria	D	positive regulation of growth	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
HKD2_k127_1960828_14	596152.DesU5LDRAFT_3545	4.617e-22	100.0	COG2026@1|root,COG2026@2|Bacteria,1N80B@1224|Proteobacteria,437Y0@68525|delta/epsilon subdivisions,2WRY3@28221|Deltaproteobacteria,2MDXE@213115|Desulfovibrionales	28221|Deltaproteobacteria	DJ	PFAM plasmid	-	-	-	ko:K06218	-	-	-	-	ko00000,ko02048	-	-	-	ParE_toxin
HKD2_k127_1960828_1	1122138.AQUZ01000049_gene2367	1.079e-263	826.0	COG0520@1|root,COG0520@2|Bacteria,2GP7W@201174|Actinobacteria,4DNX7@85009|Propionibacteriales	201174|Actinobacteria	E	Aminotransferase class-V	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
HKD2_k127_1960828_15	44060.JODL01000014_gene3665	1.188e-10	66.0	COG1396@1|root,COG2856@1|root,COG1396@2|Bacteria,COG2856@2|Bacteria,2IEJJ@201174|Actinobacteria	201174|Actinobacteria	K	IrrE N-terminal-like domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_19,HTH_3,HTH_31,Peptidase_M78
HKD2_k127_1960828_16	557599.MKAN_19220	3.503e-10	67.0	2EM4G@1|root,33ETW@2|Bacteria,2GQWR@201174|Actinobacteria,23BGH@1762|Mycobacteriaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1960828_11	656024.FsymDg_3831	4.091e-36	152.0	COG1848@1|root,COG1848@2|Bacteria,2IKT8@201174|Actinobacteria	201174|Actinobacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	ko:K07064	-	-	-	-	ko00000	-	-	-	PIN
HKD2_k127_1960828_8	1380356.JNIK01000015_gene2501	2.355e-66	236.0	COG1277@1|root,COG1277@2|Bacteria,2ID14@201174|Actinobacteria,4EUG6@85013|Frankiales	201174|Actinobacteria	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2
HKD2_k127_1960828_6	479431.Namu_0353	2.223e-112	370.0	COG1131@1|root,COG1131@2|Bacteria,2GKEH@201174|Actinobacteria,4ETYX@85013|Frankiales	201174|Actinobacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
HKD2_k127_1960828_0	656024.FsymDg_1745	8.655e-271	841.0	COG0488@1|root,COG0488@2|Bacteria,2GKQ4@201174|Actinobacteria,4ES5N@85013|Frankiales	201174|Actinobacteria	S	PFAM ABC transporter	ybiT	-	-	ko:K06158	-	-	-	-	ko00000,ko03012	-	-	-	ABC_tran,ABC_tran_Xtn,DLIC
HKD2_k127_1960828_17	1352941.M877_06225	0.0006163	49.0	COG2197@1|root,COG2197@2|Bacteria,2GNUE@201174|Actinobacteria	201174|Actinobacteria	K	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	GerE
HKD2_k127_1978289_3	1385521.N803_10715	5.072e-08	57.0	COG2161@1|root,COG2161@2|Bacteria,2GRC8@201174|Actinobacteria,4FJ8S@85021|Intrasporangiaceae	201174|Actinobacteria	D	Antitoxin component of a toxin-antitoxin (TA) module	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
HKD2_k127_1978289_1	1380393.JHVP01000007_gene4452	1.6e-113	395.0	COG1960@1|root,COG1960@2|Bacteria,2H211@201174|Actinobacteria	201174|Actinobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_N
HKD2_k127_1978289_0	1380393.JHVP01000007_gene4451	5.819e-159	516.0	COG1960@1|root,COG1960@2|Bacteria,2GJDT@201174|Actinobacteria,4ETUF@85013|Frankiales	201174|Actinobacteria	I	Acyl-CoA dehydrogenase, middle domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HKD2_k127_1978289_2	59538.XP_005974403.1	1.614e-19	103.0	COG0318@1|root,KOG1176@2759|Eukaryota,3AIZB@33154|Opisthokonta,3BXNQ@33208|Metazoa,3DFMP@33213|Bilateria,48SPA@7711|Chordata,49P71@7742|Vertebrata,3JP3T@40674|Mammalia,4J1NF@91561|Cetartiodactyla	33208|Metazoa	I	4-coumarate--CoA	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
HKD2_k127_1999464_6	356851.JOAN01000003_gene1631	2.679e-63	229.0	COG1461@1|root,COG1461@2|Bacteria,2GKII@201174|Actinobacteria,4D8DT@85008|Micromonosporales	201174|Actinobacteria	S	Dak phosphatase	dak3	-	-	ko:K07030	-	-	-	-	ko00000	-	-	-	Dak1_2,Dak2
HKD2_k127_1999464_9	644283.Micau_1351	4.81e-36	153.0	COG1461@1|root,COG1461@2|Bacteria,2GKII@201174|Actinobacteria,4D8DT@85008|Micromonosporales	201174|Actinobacteria	S	Dak phosphatase	dak3	-	-	ko:K07030	-	-	-	-	ko00000	-	-	-	Dak1_2,Dak2
HKD2_k127_1999464_1	106370.Francci3_3607	4.33e-309	962.0	COG1200@1|root,COG1200@2|Bacteria,2GKA3@201174|Actinobacteria,4ERTE@85013|Frankiales	201174|Actinobacteria	L	nucleic acid binding OB-fold tRNA helicase-type	recG	GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009987,GO:0010501,GO:0016020,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070035,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:1901360	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge,tRNA_anti-codon
HKD2_k127_1999464_8	222534.KB893794_gene2495	2.157e-59	215.0	COG0742@1|root,COG0742@2|Bacteria,2GQ3G@201174|Actinobacteria,4ESRZ@85013|Frankiales	201174|Actinobacteria	L	Methyltransferase	rsmD	-	2.1.1.171	ko:K08316	-	-	R07234	RC00003	ko00000,ko01000,ko03009	-	-	-	Cons_hypoth95
HKD2_k127_1999464_5	749414.SBI_03494	2.96e-67	248.0	COG0669@1|root,COG0669@2|Bacteria,2GN1S@201174|Actinobacteria	201174|Actinobacteria	H	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate	coaD	-	2.7.7.3	ko:K00954	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
HKD2_k127_1999464_7	196162.Noca_3282	1.107e-61	220.0	COG1399@1|root,COG1399@2|Bacteria,2GJTS@201174|Actinobacteria,4DQUU@85009|Propionibacteriales	201174|Actinobacteria	S	Uncharacterized ACR, COG1399	-	GO:0008150,GO:0040007	-	ko:K07040	-	-	-	-	ko00000	-	-	-	DUF177
HKD2_k127_1999464_11	222534.KB893794_gene2499	5.316e-23	108.0	COG0333@1|root,COG0333@2|Bacteria,2GQP3@201174|Actinobacteria,4ETHQ@85013|Frankiales	201174|Actinobacteria	J	Belongs to the bacterial ribosomal protein bL32 family	rpmF	-	-	ko:K02911	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_L32p
HKD2_k127_1999464_4	35754.JNYJ01000005_gene5383	2.261e-69	247.0	COG0416@1|root,COG0416@2|Bacteria,2I8WT@201174|Actinobacteria,4D9DB@85008|Micromonosporales	201174|Actinobacteria	I	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA	plsX	-	2.3.1.15	ko:K03621	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FA_synthesis
HKD2_k127_1999464_13	1229780.BN381_330020	1.798e-07	64.0	COG0236@1|root,COG0236@2|Bacteria	2|Bacteria	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	acpP	-	2.7.9.2	ko:K01007,ko:K02078	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PP-binding
HKD2_k127_1999464_3	656024.FsymDg_3685	5.162e-103	352.0	COG0571@1|root,COG0571@2|Bacteria,2GKER@201174|Actinobacteria,4ES99@85013|Frankiales	201174|Actinobacteria	J	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism	rnc	GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004525,GO:0004540,GO:0005488,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0032296,GO:0034641,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901363	3.1.26.3	ko:K03685	ko03008,ko05205,map03008,map05205	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019,ko03036	-	-	-	Ribonucleas_3_3,dsrm
HKD2_k127_1999464_2	298655.KI912267_gene6718	2.796e-130	421.0	COG0266@1|root,COG0266@2|Bacteria,2GJNT@201174|Actinobacteria,4ERGU@85013|Frankiales	201174|Actinobacteria	L	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates	fpg	GO:0000702,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006979,GO:0008150,GO:0008152,GO:0008534,GO:0009987,GO:0016020,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034039,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
HKD2_k127_1999464_10	1445613.JALM01000068_gene5296	3.384e-29	120.0	COG1254@1|root,COG1254@2|Bacteria,2IQ4M@201174|Actinobacteria,4E5XK@85010|Pseudonocardiales	201174|Actinobacteria	C	Belongs to the acylphosphatase family	acyP	GO:0003674,GO:0003824,GO:0003998,GO:0016787,GO:0016817,GO:0016818	3.6.1.7	ko:K01512	ko00620,ko00627,ko01120,map00620,map00627,map01120	-	R00317,R01421,R01515	RC00043	ko00000,ko00001,ko01000	-	-	-	Acylphosphatase
HKD2_k127_1999464_0	656024.FsymDg_3679	7.661e-318	998.0	COG1196@1|root,COG1196@2|Bacteria,2GK93@201174|Actinobacteria,4ERQY@85013|Frankiales	201174|Actinobacteria	D	Required for chromosome condensation and partitioning	smc	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
HKD2_k127_2022322_4	365528.KB891209_gene2194	1.19e-23	108.0	COG0631@1|root,COG0631@2|Bacteria,2GJ3M@201174|Actinobacteria,4ERJW@85013|Frankiales	201174|Actinobacteria	T	protein phosphatase 2C domain protein	pstP	GO:0000287,GO:0001932,GO:0001933,GO:0003674,GO:0003824,GO:0004647,GO:0004721,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006469,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009892,GO:0009987,GO:0010563,GO:0010605,GO:0016020,GO:0016021,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019220,GO:0019222,GO:0019538,GO:0030145,GO:0030312,GO:0031224,GO:0031226,GO:0031323,GO:0031324,GO:0031399,GO:0031400,GO:0032268,GO:0032269,GO:0033673,GO:0036211,GO:0042325,GO:0042326,GO:0042578,GO:0043085,GO:0043086,GO:0043167,GO:0043169,GO:0043170,GO:0043392,GO:0043412,GO:0043549,GO:0044092,GO:0044093,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0045859,GO:0045936,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0051098,GO:0051100,GO:0051101,GO:0051171,GO:0051172,GO:0051174,GO:0051246,GO:0051248,GO:0051338,GO:0051348,GO:0060255,GO:0065007,GO:0065009,GO:0071704,GO:0071944,GO:0080090,GO:0140096,GO:1901564	3.1.3.16	ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C,PP2C_2
HKD2_k127_2022322_0	656024.FsymDg_0175	1.754e-214	678.0	COG0772@1|root,COG0772@2|Bacteria,2GJTI@201174|Actinobacteria,4ERWV@85013|Frankiales	201174|Actinobacteria	D	Belongs to the SEDS family	rodA	GO:0002682,GO:0002684,GO:0008150,GO:0009605,GO:0009607,GO:0009987,GO:0035821,GO:0043207,GO:0044003,GO:0044403,GO:0044419,GO:0048518,GO:0048583,GO:0048584,GO:0050776,GO:0050778,GO:0050789,GO:0050896,GO:0051301,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0052031,GO:0052173,GO:0052200,GO:0052255,GO:0052552,GO:0052553,GO:0052555,GO:0052556,GO:0052564,GO:0052572,GO:0065007,GO:0075136	-	ko:K03588	ko04112,map04112	-	-	-	ko00000,ko00001,ko02000,ko03036	2.A.103.1	-	-	FTSW_RODA_SPOVE
HKD2_k127_2022322_1	222534.KB893717_gene1957	5.924e-188	610.0	COG0768@1|root,COG0768@2|Bacteria,2GJUQ@201174|Actinobacteria,4ERJZ@85013|Frankiales	201174|Actinobacteria	M	PFAM penicillin-binding protein transpeptidase	pbpA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K05364	ko00550,map00550	-	R04519	RC00005,RC00049	ko00000,ko00001,ko01011	-	-	-	Transpeptidase
HKD2_k127_2022322_2	326424.FRAAL6754	1.377e-134	453.0	COG0515@1|root,COG0515@2|Bacteria,2GMPZ@201174|Actinobacteria,4ESG4@85013|Frankiales	201174|Actinobacteria	KLT	Serine threonine protein kinase	pknA	GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008360,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0022603,GO:0022604,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0036211,GO:0040007,GO:0042304,GO:0043085,GO:0043086,GO:0043170,GO:0043388,GO:0043412,GO:0044092,GO:0044093,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046777,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0051055,GO:0051098,GO:0051099,GO:0051101,GO:0051128,GO:0062012,GO:0062014,GO:0065007,GO:0065008,GO:0065009,GO:0071704,GO:0071944,GO:0080090,GO:0140096,GO:1901564	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
HKD2_k127_2022322_3	656024.FsymDg_0178	2.077e-133	443.0	COG0515@1|root,COG2815@1|root,COG0515@2|Bacteria,COG2815@2|Bacteria,2GJ1J@201174|Actinobacteria,4EX2B@85013|Frankiales	201174|Actinobacteria	KLT	Serine threonine protein kinase	pknB	GO:0000270,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0006022,GO:0006023,GO:0006024,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008047,GO:0008150,GO:0008152,GO:0008360,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009605,GO:0009607,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0010698,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0022603,GO:0022604,GO:0030145,GO:0030203,GO:0030234,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032091,GO:0034645,GO:0036211,GO:0040007,GO:0042304,GO:0042546,GO:0042802,GO:0043085,GO:0043086,GO:0043167,GO:0043169,GO:0043170,GO:0043207,GO:0043388,GO:0043393,GO:0043412,GO:0044036,GO:0044038,GO:0044085,GO:0044092,GO:0044093,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044403,GO:0044419,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046777,GO:0046872,GO:0046890,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0050896,GO:0051055,GO:0051098,GO:0051099,GO:0051100,GO:0051101,GO:0051128,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0062012,GO:0062014,GO:0065007,GO:0065008,GO:0065009,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0075136,GO:0080090,GO:0098772,GO:0140096,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
HKD2_k127_2034926_11	103733.JNYO01000024_gene9147	1.206e-05	47.0	COG0649@1|root,COG0649@2|Bacteria,2GKEZ@201174|Actinobacteria,4E105@85010|Pseudonocardiales	201174|Actinobacteria	C	Belongs to the complex I 49 kDa subunit family	nuoD	-	1.6.5.3	ko:K00333	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa
HKD2_k127_2034926_1	561175.KB894093_gene4261	5.584e-201	630.0	COG0649@1|root,COG0649@2|Bacteria,2GKEZ@201174|Actinobacteria,4EI4P@85012|Streptosporangiales	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoD	-	1.6.5.3	ko:K00333	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa
HKD2_k127_2034926_5	469371.Tbis_3428	2.979e-101	338.0	COG1565@1|root,COG1565@2|Bacteria,2GKIU@201174|Actinobacteria,4DZ41@85010|Pseudonocardiales	201174|Actinobacteria	S	Putative S-adenosyl-L-methionine-dependent methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_28
HKD2_k127_2034926_9	1306174.JODP01000018_gene4470	2.126e-12	70.0	COG0715@1|root,COG0715@2|Bacteria,2I95I@201174|Actinobacteria	201174|Actinobacteria	P	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2034926_8	446462.Amir_2815	1.079e-30	131.0	COG0500@1|root,COG2226@2|Bacteria,2II6W@201174|Actinobacteria	201174|Actinobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
HKD2_k127_2034926_6	1380346.JNIH01000018_gene5363	5.799e-91	308.0	COG5495@1|root,COG5495@2|Bacteria,2I2F6@201174|Actinobacteria	201174|Actinobacteria	S	Oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DUF2520,Rossmann-like
HKD2_k127_2034926_4	298655.KI912266_gene1388	5.358e-109	376.0	COG0414@1|root,COG0414@2|Bacteria,2GJEQ@201174|Actinobacteria,4ESFF@85013|Frankiales	201174|Actinobacteria	H	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate	panC	GO:0003674,GO:0003824,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006573,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605	6.3.2.1	ko:K01918	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R02473	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_ligase
HKD2_k127_2034926_7	106370.Francci3_4376	6.175e-56	213.0	COG0853@1|root,COG0853@2|Bacteria,2IHTC@201174|Actinobacteria,4ESSN@85013|Frankiales	201174|Actinobacteria	H	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine	panD	-	4.1.1.11	ko:K01579	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R00489	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Asp_decarbox
HKD2_k127_2034926_0	222534.KB893714_gene1645	1.023e-245	783.0	COG0029@1|root,COG0029@2|Bacteria,2I2IJ@201174|Actinobacteria,4ERDS@85013|Frankiales	201174|Actinobacteria	H	Catalyzes the oxidation of L-aspartate to iminoaspartate	nadB	-	1.4.3.16,2.4.2.19	ko:K00278,ko:K00767	ko00250,ko00760,ko01100,map00250,map00760,map01100	M00115	R00357,R00481,R03348	RC00006,RC02566,RC02877	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
HKD2_k127_2034926_3	298655.KI912266_gene1386	4.17e-113	384.0	COG0157@1|root,COG0157@2|Bacteria,2I2IP@201174|Actinobacteria	201174|Actinobacteria	H	Belongs to the NadC ModD family	nadC	-	2.4.2.19	ko:K00767	ko00760,ko01100,map00760,map01100	M00115	R03348	RC02877	ko00000,ko00001,ko00002,ko01000	-	-	-	QRPTase_C,QRPTase_N
HKD2_k127_2034926_2	298655.KI912266_gene1385	2.044e-121	409.0	COG1521@1|root,COG1521@2|Bacteria,2GMRQ@201174|Actinobacteria,4ES26@85013|Frankiales	201174|Actinobacteria	F	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis	coaX	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	2.7.1.33	ko:K03525	ko00770,ko01100,map00770,map01100	M00120	R02971,R03018,R04391	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Pan_kinase
HKD2_k127_2069706_4	28444.JODQ01000001_gene2301	4.675e-22	103.0	2D9MJ@1|root,32TTI@2|Bacteria,2IFFM@201174|Actinobacteria,4ERBF@85012|Streptosporangiales	201174|Actinobacteria	C	Cytochrome c oxidase subunit IV	ctaF	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Cyt_c_ox_IV
HKD2_k127_2069706_2	1101188.KI912155_gene3059	7.784e-64	224.0	2DMBY@1|root,32ICA@2|Bacteria,2IFRZ@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2069706_1	1265310.CCBD010000070_gene38	4.282e-76	270.0	COG2267@1|root,COG2267@2|Bacteria,2I5VQ@201174|Actinobacteria	201174|Actinobacteria	I	Gluconate 2-dehydrogenase subunit 3	-	-	-	-	-	-	-	-	-	-	-	-	Gluconate_2-dh3
HKD2_k127_2069706_0	298654.FraEuI1c_6541	8.799e-278	877.0	COG2303@1|root,COG2303@2|Bacteria,2I5YA@201174|Actinobacteria,4ET01@85013|Frankiales	201174|Actinobacteria	E	GMC oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GMC_oxred_C,GMC_oxred_N,Gluconate_2-dh3
HKD2_k127_2069706_3	326424.FRAAL5109	1.109e-47	192.0	COG1290@1|root,COG1290@2|Bacteria,2GJ1E@201174|Actinobacteria,4ERM6@85013|Frankiales	201174|Actinobacteria	C	Cytochrome b	qcrB	-	-	ko:K03891	ko00190,ko01100,map00190,map01100	M00151	-	-	ko00000,ko00001,ko00002	-	-	-	Cytochrom_B_N_2
HKD2_k127_2071478_4	1123023.JIAI01000014_gene3692	4.64e-35	137.0	COG0020@1|root,COG0020@2|Bacteria,2GJCP@201174|Actinobacteria,4DYMM@85010|Pseudonocardiales	201174|Actinobacteria	I	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids	uppS1	GO:0000287,GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016020,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0030145,GO:0033850,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0046872,GO:0046914,GO:0071704,GO:0071944,GO:1901576,GO:1901615,GO:1901617	2.5.1.31,2.5.1.68	ko:K00806,ko:K12503	ko00900,ko01110,map00900,map01110	-	R06447,R08528	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
HKD2_k127_2071478_2	391625.PPSIR1_25986	1.281e-89	315.0	COG1866@1|root,COG1866@2|Bacteria	2|Bacteria	H	phosphoenolpyruvate carboxykinase (ATP) activity	pckA	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004611,GO:0004612,GO:0005488,GO:0005509,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006094,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0016051,GO:0016829,GO:0016830,GO:0016831,GO:0017076,GO:0019318,GO:0019319,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0044238,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046364,GO:0046872,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901576	4.1.1.49	ko:K01610	ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200	M00003,M00170	R00341	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_3169,iSB619.SA_RS09060,iSF_1195.SF3422,iUTI89_1310.UTI89_C3903,iYO844.BSU30560	PEPCK_ATP
HKD2_k127_2071478_1	106370.Francci3_3898	3.573e-92	308.0	COG1272@1|root,COG1272@2|Bacteria,2GJGQ@201174|Actinobacteria,4EV3P@85013|Frankiales	201174|Actinobacteria	S	TIGRFAM channel protein, hemolysin III family	hlyIII	-	-	ko:K11068	-	-	-	-	ko00000,ko02042	-	-	-	HlyIII
HKD2_k127_2071478_3	656024.FsymDg_0783	7.711e-83	279.0	28M3Q@1|root,2ZAHT@2|Bacteria,2GM5B@201174|Actinobacteria,4ESKK@85013|Frankiales	201174|Actinobacteria	-	-	-	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2071478_0	656024.FsymDg_0782	4.296e-281	874.0	COG1331@1|root,COG1331@2|Bacteria,2GJ88@201174|Actinobacteria,4ETUV@85013|Frankiales	201174|Actinobacteria	O	Protein of unknown function, DUF255	-	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	GlcNAc_2-epim,Thioredox_DsbH
HKD2_k127_2077540_25	298653.Franean1_3580	5.332e-05	45.0	COG3335@1|root,COG3335@2|Bacteria,2GJQI@201174|Actinobacteria,4ERUS@85013|Frankiales	201174|Actinobacteria	L	manually curated	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_32
HKD2_k127_2077540_19	1048983.EL17_18805	5.632e-15	89.0	COG4733@1|root,COG4733@2|Bacteria	2|Bacteria	S	cellulase activity	-	-	3.2.1.80	ko:K03332	ko00051,map00051	-	R00879	-	ko00000,ko00001,ko01000	-	-	-	Big_2,CW_binding_1,F5_F8_type_C,Flg_new,Glyco_hydro_32C,Glyco_hydro_32N,SLH
HKD2_k127_2077540_10	365528.KB891115_gene1617	5.139e-53	205.0	COG3206@1|root,COG3206@2|Bacteria,2IJJ8@201174|Actinobacteria,4ETM2@85013|Frankiales	201174|Actinobacteria	M	Domain of unknown function (DUF4407)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4407
HKD2_k127_2077540_6	561175.KB894093_gene2885	5.69e-107	383.0	COG1337@1|root,COG1337@2|Bacteria,2IJNN@201174|Actinobacteria	201174|Actinobacteria	L	RAMP superfamily	-	-	-	-	-	-	-	-	-	-	-	-	RAMPs
HKD2_k127_2077540_17	1173022.Cri9333_0582	1.733e-16	88.0	2CW7X@1|root,32SZ4@2|Bacteria,1G7W3@1117|Cyanobacteria,1HCAS@1150|Oscillatoriales	1117|Cyanobacteria	S	TIGRFAM CRISPR-associated protein, TIGR03984 family	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2077540_15	561175.KB894093_gene2882	1.368e-23	109.0	COG1337@1|root,COG1337@2|Bacteria,2IR5M@201174|Actinobacteria	201174|Actinobacteria	L	RAMP superfamily	-	-	-	-	-	-	-	-	-	-	-	-	RAMPs
HKD2_k127_2077540_11	561175.KB894093_gene2882	4.597e-43	183.0	COG1337@1|root,COG1337@2|Bacteria,2IR5M@201174|Actinobacteria	201174|Actinobacteria	L	RAMP superfamily	-	-	-	-	-	-	-	-	-	-	-	-	RAMPs
HKD2_k127_2077540_4	1120936.KB907215_gene3959	2.606e-144	504.0	COG1337@1|root,COG1337@2|Bacteria,2IN7Q@201174|Actinobacteria	201174|Actinobacteria	L	RAMP superfamily	-	-	-	ko:K19134	-	-	-	-	ko00000,ko02048	-	-	-	Cas_Cmr3,RAMPs
HKD2_k127_2077540_5	561175.KB894093_gene2884	5.439e-107	366.0	COG1353@1|root,COG1353@2|Bacteria,2H5E8@201174|Actinobacteria	201174|Actinobacteria	S	crispr-associated protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2077540_9	1894.JOER01000049_gene5112	1.244e-71	255.0	COG1592@1|root,COG1592@2|Bacteria,2I8N0@201174|Actinobacteria	201174|Actinobacteria	C	Rubrerythrin	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
HKD2_k127_2077540_1	1122611.KB903958_gene4039	1.402e-176	565.0	COG0446@1|root,COG0446@2|Bacteria,2GRTN@201174|Actinobacteria	201174|Actinobacteria	P	pyridine nucleotide-disulphide oxidoreductase	fccB	-	1.8.5.4	ko:K17218	ko00920,map00920	-	R10152	RC03155	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
HKD2_k127_2077540_0	1348663.KCH_03130	2.071e-183	584.0	COG0477@1|root,COG2814@2|Bacteria,2GNBV@201174|Actinobacteria,2M4UY@2063|Kitasatospora	201174|Actinobacteria	EGP	Sugar (and other) transporter	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD2_k127_2077540_20	1134445.AJJM01000011_gene3529	3.856e-13	76.0	COG0553@1|root,COG0553@2|Bacteria,2GM2V@201174|Actinobacteria	201174|Actinobacteria	L	helicase	-	-	-	-	-	-	-	-	-	-	-	-	Helicase_C,SNF2_N
HKD2_k127_2077540_14	1095769.CAHF01000013_gene3178	1.275e-30	125.0	COG5470@1|root,COG5470@2|Bacteria,1N54U@1224|Proteobacteria	1224|Proteobacteria	S	Domain of unknown function (DUF1330)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1330
HKD2_k127_2077540_18	66373.JOFQ01000006_gene2857	5.491e-15	79.0	COG0454@1|root,COG1846@1|root,COG0456@2|Bacteria,COG1846@2|Bacteria,2GNNG@201174|Actinobacteria	201174|Actinobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,MarR_2
HKD2_k127_2077540_13	928724.SacglDRAFT_03688	6.116e-33	139.0	COG3293@1|root,COG3293@2|Bacteria,2IIAY@201174|Actinobacteria,4E3DP@85010|Pseudonocardiales	201174|Actinobacteria	L	PFAM Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_2,DUF4096
HKD2_k127_2077540_16	58344.JOEL01000127_gene1096	2.82e-17	84.0	COG3293@1|root,COG3293@2|Bacteria,2IIB4@201174|Actinobacteria	201174|Actinobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4096
HKD2_k127_2077540_8	1123023.JIAI01000003_gene3069	4.675e-77	269.0	COG4106@1|root,COG4106@2|Bacteria,2GJMG@201174|Actinobacteria	201174|Actinobacteria	E	Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate	-	-	2.1.1.144	ko:K00598	-	-	-	-	ko00000,ko01000	-	-	-	Methyltransf_25
HKD2_k127_2077540_3	1301098.PKB_5481	2.666e-158	519.0	COG0659@1|root,COG0659@2|Bacteria,1MWDF@1224|Proteobacteria,1SYC8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	COG0659 Sulfate permease and related transporters (MFS superfamily)	-	-	-	-	-	-	-	-	-	-	-	-	STAS,Sulfate_transp
HKD2_k127_2077540_2	1306174.JODP01000005_gene1719	2.741e-175	564.0	COG0477@1|root,COG0477@2|Bacteria,2GIUM@201174|Actinobacteria	201174|Actinobacteria	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_3,Sugar_tr
HKD2_k127_2077634_3	469383.Cwoe_0848	6.874e-08	60.0	COG2161@1|root,COG2161@2|Bacteria,2HRW6@201174|Actinobacteria,4CTZM@84995|Rubrobacteria	84995|Rubrobacteria	D	Antitoxin Phd_YefM, type II toxin-antitoxin system	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
HKD2_k127_2077634_0	2074.JNYD01000001_gene6279	2.243e-250	782.0	COG2217@1|root,COG2217@2|Bacteria,2GIRF@201174|Actinobacteria,4E0K7@85010|Pseudonocardiales	201174|Actinobacteria	P	haloacid dehalogenase-like hydrolase	-	-	3.6.3.4,3.6.3.54	ko:K01533,ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
HKD2_k127_2077634_1	298655.KI912266_gene2628	2.242e-114	385.0	COG2217@1|root,COG2217@2|Bacteria,2GIRF@201174|Actinobacteria,4ERFZ@85013|Frankiales	201174|Actinobacteria	P	E1-E2 ATPase	-	-	3.6.3.4,3.6.3.54	ko:K01533,ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
HKD2_k127_2077634_2	882083.SacmaDRAFT_5399	8.855e-78	261.0	COG1484@1|root,COG1484@2|Bacteria,2H714@201174|Actinobacteria,4E2EK@85010|Pseudonocardiales	201174|Actinobacteria	L	PFAM IstB-like ATP-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21,UPF0114
HKD2_k127_2077634_4	298653.Franean1_3580	5.332e-05	45.0	COG3335@1|root,COG3335@2|Bacteria,2GJQI@201174|Actinobacteria,4ERUS@85013|Frankiales	201174|Actinobacteria	L	manually curated	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_32
HKD2_k127_2116258_1	106370.Francci3_3595	5.143e-117	379.0	COG0541@1|root,COG0541@2|Bacteria,2GK4R@201174|Actinobacteria,4ERD5@85013|Frankiales	201174|Actinobacteria	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY	ffh	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
HKD2_k127_2116258_0	1095767.CAHD01000213_gene627	1.043e-218	696.0	COG0405@1|root,COG0405@2|Bacteria,2GJYW@201174|Actinobacteria	201174|Actinobacteria	E	gamma-glutamyltransferase	ggt	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
HKD2_k127_2116258_2	67275.JOAP01000028_gene215	4.158e-12	66.0	COG0552@1|root,COG0552@2|Bacteria,2GJQH@201174|Actinobacteria	201174|Actinobacteria	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)	ftsY	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2,3.A.5.7	-	-	SRP54,SRP54_N
HKD2_k127_211710_2	1121272.KB903250_gene2835	1.892e-83	282.0	COG0412@1|root,COG0412@2|Bacteria,2GJMH@201174|Actinobacteria,4D93K@85008|Micromonosporales	201174|Actinobacteria	Q	Dienelactone hydrolase family	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
HKD2_k127_211710_1	106370.Francci3_3919	7.032e-107	363.0	COG1573@1|root,COG1573@2|Bacteria,2GK1I@201174|Actinobacteria,4ERCZ@85013|Frankiales	201174|Actinobacteria	L	uracil-DNA glycosylase	udgB	GO:0003674,GO:0003824,GO:0004844,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0033958,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0048037,GO:0050896,GO:0051536,GO:0051540,GO:0051716,GO:0071704,GO:0090304,GO:0097506,GO:0140097,GO:1901360	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
HKD2_k127_211710_0	656024.FsymDg_0763	2.527e-227	711.0	COG1252@1|root,COG1252@2|Bacteria,2GJFE@201174|Actinobacteria,4ERDB@85013|Frankiales	201174|Actinobacteria	C	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	1.6.99.3	ko:K03885	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
HKD2_k127_211710_4	391037.Sare_4707	9.824e-39	152.0	COG2716@1|root,COG2716@2|Bacteria,2IGKE@201174|Actinobacteria,4DCUR@85008|Micromonosporales	201174|Actinobacteria	E	Amino acid-binding act domain protein	-	-	-	ko:K03567	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000	-	-	-	ACT_6
HKD2_k127_211710_3	35754.JNYJ01000036_gene3720	6.983e-51	201.0	COG0242@1|root,COG0242@2|Bacteria,2HMJS@201174|Actinobacteria,4DBU9@85008|Micromonosporales	201174|Actinobacteria	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions	-	-	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	Pep_deformylase
HKD2_k127_2120342_1	656024.FsymDg_1227	3.82e-92	309.0	COG0411@1|root,COG0411@2|Bacteria,2IFYS@201174|Actinobacteria	201174|Actinobacteria	E	ABC transporter	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
HKD2_k127_2120342_2	656024.FsymDg_1226	8.234e-80	284.0	COG0410@1|root,COG0410@2|Bacteria,2H96G@201174|Actinobacteria,4EUA4@85013|Frankiales	201174|Actinobacteria	E	ABC transporter	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
HKD2_k127_2120342_0	656024.FsymDg_1225	7.455e-169	538.0	COG0683@1|root,COG0683@2|Bacteria,2GMDG@201174|Actinobacteria	201174|Actinobacteria	E	Periplasmic binding protein	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
HKD2_k127_212640_2	298655.KI912267_gene6646	8.061e-177	557.0	COG1674@1|root,COG1674@2|Bacteria,2GK3T@201174|Actinobacteria,4ERQD@85013|Frankiales	201174|Actinobacteria	D	DNA translocase ftsK	ftsK	GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
HKD2_k127_212640_6	656024.FsymDg_3619	7.141e-60	217.0	COG1426@1|root,COG1426@2|Bacteria,2I7J4@201174|Actinobacteria,4EWG7@85013|Frankiales	201174|Actinobacteria	S	Domain of unknown function (DUF4115)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4115,HTH_25
HKD2_k127_212640_5	1108045.GORHZ_154_00530	1.424e-64	231.0	COG0558@1|root,COG0558@2|Bacteria,2GK5D@201174|Actinobacteria,4GB4D@85026|Gordoniaceae	201174|Actinobacteria	I	CDP-alcohol phosphatidyltransferase	pgsA	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008444,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016740,GO:0016772,GO:0016780,GO:0017169,GO:0019637,GO:0030312,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0045017,GO:0046474,GO:0046486,GO:0071704,GO:0071944,GO:0090407,GO:1901576	2.7.8.41,2.7.8.5	ko:K00995,ko:K08744	ko00564,ko01100,map00564,map01100	-	R01801,R02030	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
HKD2_k127_212640_1	326424.FRAAL5732	2.522e-182	582.0	COG1058@1|root,COG1546@1|root,COG1058@2|Bacteria,COG1546@2|Bacteria,2IQ8T@201174|Actinobacteria,4ERZM@85013|Frankiales	201174|Actinobacteria	S	Belongs to the CinA family	cinA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	3.5.1.42	ko:K03742,ko:K03743	ko00760,map00760	-	R02322	RC00100	ko00000,ko00001,ko01000	-	-	-	CinA,MoCF_biosynth
HKD2_k127_212640_9	710111.FraQA3DRAFT_5858	1.47e-32	128.0	COG1396@1|root,COG1396@2|Bacteria,2GR3F@201174|Actinobacteria,4ETB8@85013|Frankiales	201174|Actinobacteria	K	PFAM helix-turn-helix domain protein	clgR	GO:0002682,GO:0002683,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006109,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0009266,GO:0009268,GO:0009408,GO:0009605,GO:0009607,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0009894,GO:0009987,GO:0010447,GO:0010468,GO:0010556,GO:0010557,GO:0010565,GO:0010604,GO:0010628,GO:0010675,GO:0019216,GO:0019217,GO:0019219,GO:0019222,GO:0022611,GO:0030162,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031329,GO:0031347,GO:0031348,GO:0032268,GO:0032502,GO:0033554,GO:0035821,GO:0040007,GO:0042176,GO:0043207,GO:0043565,GO:0043620,GO:0044003,GO:0044110,GO:0044111,GO:0044114,GO:0044115,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044413,GO:0044414,GO:0044419,GO:0045088,GO:0045824,GO:0045893,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048583,GO:0048585,GO:0050776,GO:0050777,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051246,GO:0051252,GO:0051254,GO:0051701,GO:0051704,GO:0051707,GO:0051716,GO:0051817,GO:0051832,GO:0051833,GO:0052031,GO:0052037,GO:0052167,GO:0052170,GO:0052173,GO:0052200,GO:0052255,GO:0052261,GO:0052306,GO:0052309,GO:0052552,GO:0052553,GO:0052561,GO:0052562,GO:0052564,GO:0052572,GO:0060255,GO:0061136,GO:0062012,GO:0065007,GO:0075136,GO:0080090,GO:0080134,GO:0085016,GO:0090062,GO:0097159,GO:1901363,GO:1902680,GO:1902882,GO:1903050,GO:1903362,GO:1903506,GO:1903508,GO:2000112,GO:2001141	-	-	-	-	-	-	-	-	-	-	HTH_31
HKD2_k127_212640_7	710111.FraQA3DRAFT_5859	2.798e-58	215.0	COG0783@1|root,COG0783@2|Bacteria,2IFDP@201174|Actinobacteria,4ETDS@85013|Frankiales	201174|Actinobacteria	P	Belongs to the Dps family	dps	-	-	ko:K04047	-	-	-	-	ko00000,ko03036	-	-	-	Ferritin
HKD2_k127_212640_4	656024.FsymDg_3614	7.955e-92	317.0	COG1842@1|root,COG1842@2|Bacteria,2GJGD@201174|Actinobacteria,4ES2S@85013|Frankiales	201174|Actinobacteria	KT	Phage shock protein A, PspA	pspA	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044464,GO:0071944	-	ko:K03969	-	-	-	-	ko00000	-	-	-	PspA_IM30
HKD2_k127_212640_3	365528.KB891241_gene6213	9.65e-109	359.0	COG0266@1|root,COG0266@2|Bacteria,2GKCW@201174|Actinobacteria,4ESKA@85013|Frankiales	201174|Actinobacteria	L	Evidence 2b Function of strongly homologous gene	nei	-	4.2.99.18	ko:K05522	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
HKD2_k127_212640_0	106370.Francci3_3527	4.37e-321	997.0	COG1201@1|root,COG1201@2|Bacteria,2GJG3@201174|Actinobacteria,4ES42@85013|Frankiales	201174|Actinobacteria	L	DEAD DEAH box helicase domain protein	lhr	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,HTH_42,Helicase_C
HKD2_k127_2142431_0	1123023.JIAI01000001_gene7344	6.749e-71	250.0	COG0518@1|root,COG0518@2|Bacteria,2GNA6@201174|Actinobacteria,4E0U1@85010|Pseudonocardiales	201174|Actinobacteria	F	PFAM Glutamine amidotransferase class-I	-	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase,Methyltransf_11
HKD2_k127_2142431_1	1116472.MGMO_118c00100	1.259e-42	162.0	COG3055@1|root,COG3055@2|Bacteria,1QE0Q@1224|Proteobacteria,1S2S0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Domain of unknown function (DUF1929)	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2161454_8	1382306.JNIM01000001_gene942	1.408e-28	129.0	COG0508@1|root,COG0508@2|Bacteria,2G619@200795|Chloroflexi	200795|Chloroflexi	C	Catalytic domain of components of various dehydrogenase complexes	-	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
HKD2_k127_2161454_3	351607.Acel_0589	7.504e-159	548.0	COG0022@1|root,COG0022@2|Bacteria,2GKFE@201174|Actinobacteria,4ESHW@85013|Frankiales	201174|Actinobacteria	C	PFAM Transketolase central region	-	-	1.2.4.1	ko:K00162	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
HKD2_k127_2161454_4	269800.Tfu_3049	3.997e-139	451.0	COG1071@1|root,COG1071@2|Bacteria,2IBRC@201174|Actinobacteria,4EJ8W@85012|Streptosporangiales	201174|Actinobacteria	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	pdhA	-	1.2.4.1	ko:K00161	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
HKD2_k127_2161454_7	351607.Acel_0591	2.552e-52	189.0	COG0517@1|root,COG1592@1|root,COG0517@2|Bacteria,COG1592@2|Bacteria,2GKSH@201174|Actinobacteria,4ETKN@85013|Frankiales	201174|Actinobacteria	C	PFAM CBS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	BON,CBS
HKD2_k127_2161454_1	405948.SACE_5677	1.576e-207	657.0	COG1249@1|root,COG1249@2|Bacteria,2GIXY@201174|Actinobacteria,4DXII@85010|Pseudonocardiales	201174|Actinobacteria	C	TIGRFAM Dihydrolipoamide dehydrogenase	-	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
HKD2_k127_2161454_0	1120936.KB907211_gene27	0.0	1167.0	COG0495@1|root,COG0495@2|Bacteria,2GJI1@201174|Actinobacteria,4EFUG@85012|Streptosporangiales	201174|Actinobacteria	J	Leucyl-tRNA synthetase, Domain 2	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
HKD2_k127_2161454_12	656024.FsymDg_0684	1.017e-06	58.0	2DIJW@1|root,303H5@2|Bacteria,2HD0U@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2161454_9	656024.FsymDg_0966	4.808e-27	126.0	COG5662@1|root,COG5662@2|Bacteria,2IM2X@201174|Actinobacteria,4ETFE@85013|Frankiales	201174|Actinobacteria	K	anti-sigma factor	rsrA	GO:0000988,GO:0000989,GO:0003674,GO:0005488,GO:0006950,GO:0006979,GO:0008150,GO:0008270,GO:0009266,GO:0009408,GO:0009593,GO:0009628,GO:0009889,GO:0010556,GO:0016989,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0032502,GO:0042221,GO:0043167,GO:0043169,GO:0043934,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051606,GO:0051775,GO:0051776,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1903506,GO:2001141	-	-	-	-	-	-	-	-	-	-	zf-HC2
HKD2_k127_2161454_5	106370.Francci3_3768	5.771e-109	359.0	COG1595@1|root,COG1595@2|Bacteria,2GJ02@201174|Actinobacteria,4ES6T@85013|Frankiales	201174|Actinobacteria	K	RNA polymerase sigma factor	sigH	GO:0005575,GO:0005618,GO:0005623,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031326,GO:0033554,GO:0034605,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051409,GO:0051716,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:1903506,GO:2000112,GO:2001141	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD2_k127_2161454_6	656024.FsymDg_0963	3.364e-97	342.0	COG0500@1|root,COG2226@2|Bacteria,2ICG1@201174|Actinobacteria	201174|Actinobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_23
HKD2_k127_2161454_10	446470.Snas_5190	1.899e-22	104.0	2CC1Y@1|root,34BAK@2|Bacteria,2IM7Z@201174|Actinobacteria,4F0BA@85014|Glycomycetales	201174|Actinobacteria	K	Transcription factor WhiB	-	-	-	ko:K18955	-	-	-	-	ko00000,ko03000	-	-	-	Whib
HKD2_k127_2161454_11	351607.Acel_0537	1.27e-19	93.0	COG1734@1|root,COG1734@2|Bacteria,2IQS3@201174|Actinobacteria	201174|Actinobacteria	T	Prokaryotic dksA/traR C4-type zinc finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-dskA_traR
HKD2_k127_2161454_2	656024.FsymDg_0962	2.807e-180	576.0	COG0128@1|root,COG0128@2|Bacteria,2GJKX@201174|Actinobacteria,4ERSF@85013|Frankiales	201174|Actinobacteria	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	GO:0003674,GO:0003824,GO:0003866,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016765,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0071704,GO:0071944,GO:1901576	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	EPSP_synthase
HKD2_k127_2161454_13	656024.FsymDg_0961	0.0001171	48.0	COG1162@1|root,COG1162@2|Bacteria,2GJ37@201174|Actinobacteria,4ES5S@85013|Frankiales	201174|Actinobacteria	S	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit	rsgA	-	3.1.3.100	ko:K06949	ko00730,ko01100,map00730,map01100	-	R00615,R02135	RC00002,RC00017	ko00000,ko00001,ko01000,ko03009	-	-	-	RsgA_GTPase
HKD2_k127_2163394_2	656024.FsymDg_4055	4.082e-124	411.0	COG0560@1|root,COG0560@2|Bacteria,2GJW9@201174|Actinobacteria,4ERWE@85013|Frankiales	201174|Actinobacteria	E	HAD-superfamily subfamily IB hydrolase, TIGR01490	serB1	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	HAD
HKD2_k127_2163394_4	1210045.ALNP01000001_gene3407	2.842e-69	241.0	COG1595@1|root,COG1595@2|Bacteria,2GJER@201174|Actinobacteria	201174|Actinobacteria	K	belongs to the sigma-70 factor family, ECF subfamily	adsA	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD2_k127_2163394_0	1122182.KB903813_gene2267	4.223e-167	541.0	COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria,4DBR0@85008|Micromonosporales	201174|Actinobacteria	IQ	AMP-binding enzyme C-terminal domain	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
HKD2_k127_2163394_5	326424.FRAAL0981	2.761e-22	113.0	COG0695@1|root,COG0695@2|Bacteria,2IR0P@201174|Actinobacteria,4ETIA@85013|Frankiales	201174|Actinobacteria	O	PFAM Glutaredoxin 2	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DUF836
HKD2_k127_2163394_3	298653.Franean1_6132	1.389e-97	326.0	COG2344@1|root,COG2344@2|Bacteria,2GMV2@201174|Actinobacteria,4ESER@85013|Frankiales	201174|Actinobacteria	K	Modulates transcription in response to changes in cellular NADH NAD( ) redox state	rex	GO:0003674,GO:0005488,GO:0005515,GO:0042802	-	ko:K01926	-	-	-	-	ko00000,ko03000	-	-	-	CoA_binding,Put_DNA-bind_N
HKD2_k127_2163394_1	710111.FraQA3DRAFT_3969	1.199e-154	509.0	COG0373@1|root,COG0373@2|Bacteria,2GJRA@201174|Actinobacteria,4ERHS@85013|Frankiales	201174|Actinobacteria	H	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)	hemA	GO:0008150,GO:0040007	1.2.1.70	ko:K02492	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R04109	RC00055,RC00149	ko00000,ko00001,ko00002,ko01000	-	-	-	GlutR_N,GlutR_dimer,Shikimate_DH
HKD2_k127_2175537_1	1121405.dsmv_1561	1.508e-35	151.0	COG1653@1|root,COG1653@2|Bacteria,1MVMW@1224|Proteobacteria,42N79@68525|delta/epsilon subdivisions,2WM0N@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K02027,ko:K05813	ko02010,map02010	M00198,M00207	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.3	-	-	SBP_bac_8
HKD2_k127_2175537_0	285535.JOEY01000047_gene1979	8.338e-55	202.0	COG1653@1|root,COG1653@2|Bacteria,2I8TG@201174|Actinobacteria	201174|Actinobacteria	G	transport	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_8
HKD2_k127_2175537_2	1306990.BARG01000021_gene2053	1.128e-06	54.0	COG1653@1|root,COG1653@2|Bacteria,2I8TG@201174|Actinobacteria	201174|Actinobacteria	G	transport	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_8
HKD2_k127_2202886_6	405948.SACE_2400	2.246e-80	272.0	COG1073@1|root,COG1926@1|root,COG1073@2|Bacteria,COG1926@2|Bacteria,2GJUU@201174|Actinobacteria,4DZTG@85010|Pseudonocardiales	201174|Actinobacteria	S	Phosphoribosyl transferase domain	-	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K07100	-	-	-	-	ko00000	-	-	-	DLH,Pribosyltran
HKD2_k127_2202886_0	1463825.JNXC01000003_gene3614	5.361e-308	960.0	COG0296@1|root,COG0296@2|Bacteria,2GJ5C@201174|Actinobacteria,4E0S6@85010|Pseudonocardiales	201174|Actinobacteria	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position	glgB	-	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48
HKD2_k127_2202886_11	521096.Tpau_0239	2.026e-24	109.0	COG2026@1|root,COG2026@2|Bacteria,2GRQR@201174|Actinobacteria	201174|Actinobacteria	DJ	PFAM plasmid stabilization system	-	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0006139,GO:0006355,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016070,GO:0016787,GO:0016788,GO:0019219,GO:0019222,GO:0019439,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0034641,GO:0034655,GO:0040008,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0045892,GO:0045926,GO:0045934,GO:0046483,GO:0046700,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0090305,GO:1901360,GO:1901361,GO:1901575,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141	-	-	-	-	-	-	-	-	-	-	ParE_toxin
HKD2_k127_2202886_9	1089453.GOSPT_037_00030	2.829e-34	134.0	COG2161@1|root,COG2161@2|Bacteria,2GUI1@201174|Actinobacteria,4GEEA@85026|Gordoniaceae	201174|Actinobacteria	D	Antitoxin component of a toxin-antitoxin (TA) module	relF	GO:0003674,GO:0005488,GO:0005515,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0040008,GO:0045927,GO:0048518,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097351,GO:1903506,GO:2000112,GO:2001141	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
HKD2_k127_2202886_1	656024.FsymDg_0655	1.148e-206	654.0	COG1004@1|root,COG1004@2|Bacteria,2GJQB@201174|Actinobacteria,4ERE2@85013|Frankiales	201174|Actinobacteria	M	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	-	-	1.1.1.22	ko:K00012	ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100	M00014,M00129,M00361,M00362	R00286	RC00291	ko00000,ko00001,ko00002,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
HKD2_k127_2202886_12	996637.SGM_1752	7.95e-14	81.0	COG0726@1|root,COG1215@1|root,COG0726@2|Bacteria,COG1215@2|Bacteria,2GJCE@201174|Actinobacteria	201174|Actinobacteria	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3,Polysacc_deac_1
HKD2_k127_2202886_4	656024.FsymDg_0656	1.191e-108	357.0	COG1215@1|root,COG1215@2|Bacteria,2I9A5@201174|Actinobacteria,4ETVX@85013|Frankiales	201174|Actinobacteria	M	Glycosyl transferase family group 2	-	-	2.4.1.212	ko:K00752	-	-	-	-	ko00000,ko01000,ko01003,ko02000	4.D.1.1.10,4.D.1.1.4,4.D.1.1.5	GT2	-	Glyco_tranf_2_3
HKD2_k127_2202886_2	656024.FsymDg_0657	2.143e-152	502.0	COG3420@1|root,COG3420@2|Bacteria,2ICN5@201174|Actinobacteria,4EVAW@85013|Frankiales	201174|Actinobacteria	P	Periplasmic copper-binding protein (NosD)	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,NosD
HKD2_k127_2202886_3	656024.FsymDg_0658	3.322e-117	395.0	COG3420@1|root,COG3420@2|Bacteria,2I8D7@201174|Actinobacteria,4EUQG@85013|Frankiales	201174|Actinobacteria	P	Parallel beta-helix repeats	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix
HKD2_k127_2202886_7	66377.JOBH01000006_gene401	7.479e-64	237.0	2DBVG@1|root,2ZBB1@2|Bacteria,2IH9V@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2202886_5	656024.FsymDg_3982	9.585e-95	325.0	COG3757@1|root,COG5479@1|root,COG3757@2|Bacteria,COG5479@2|Bacteria,2GKS0@201174|Actinobacteria,4EW47@85013|Frankiales	201174|Actinobacteria	M	PFAM glycoside hydrolase family 25	-	-	-	ko:K07273	-	-	-	-	ko00000	-	-	-	Glyco_hydro_25,LGFP,PG_binding_1
HKD2_k127_2202886_8	1116232.AHBF01000001_gene6008	8.774e-50	190.0	COG1812@1|root,COG1812@2|Bacteria,2IEH8@201174|Actinobacteria	201174|Actinobacteria	E	S-adenosylmethionine synthetase (AdoMet synthetase)	-	-	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	AdoMet_Synthase
HKD2_k127_2202886_10	1122182.KB903835_gene4256	7.981e-31	124.0	COG1478@1|root,COG1670@1|root,COG1478@2|Bacteria,COG1670@2|Bacteria,2HNQP@201174|Actinobacteria,4DFSH@85008|Micromonosporales	201174|Actinobacteria	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
HKD2_k127_2202941_3	1173026.Glo7428_1067	2.507e-39	153.0	COG2897@1|root,COG2897@2|Bacteria,1G4X6@1117|Cyanobacteria	1117|Cyanobacteria	P	PFAM Rhodanese-like domain	-	-	2.8.1.1,2.8.1.2	ko:K01011	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko01000	-	-	-	Rhodanese
HKD2_k127_2202941_1	463191.SSEG_06059	1.843e-74	259.0	COG2085@1|root,COG2085@2|Bacteria,2GMN3@201174|Actinobacteria	201174|Actinobacteria	S	NADP oxidoreductase coenzyme F420-dependent	-	-	1.5.1.40	ko:K06988	-	-	-	-	ko00000,ko01000	-	-	-	F420_oxidored
HKD2_k127_2202941_2	284031.JNXD01000003_gene3747	8.478e-40	164.0	COG4635@1|root,COG4635@2|Bacteria,2IQCQ@201174|Actinobacteria	201174|Actinobacteria	CH	Flavodoxin domain	-	-	1.3.5.3	ko:K00230	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R09489	RC00885	ko00000,ko00001,ko00002,ko01000	-	-	-	Flavodoxin_5
HKD2_k127_2202941_5	1125971.ASJB01000022_gene6937	2.26e-05	53.0	COG1366@1|root,COG1366@2|Bacteria	2|Bacteria	T	antisigma factor binding	-	-	-	ko:K03090,ko:K04749,ko:K06378	-	-	-	-	ko00000,ko03021	-	-	-	STAS,STAS_2
HKD2_k127_2202941_4	446462.Amir_1760	5.94e-31	136.0	COG3832@1|root,COG3832@2|Bacteria,2IKZ7@201174|Actinobacteria,4E4I0@85010|Pseudonocardiales	201174|Actinobacteria	S	PFAM Polyketide cyclase dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
HKD2_k127_2202941_0	665577.JH993790_gene5022	1.179e-217	689.0	COG1233@1|root,COG1233@2|Bacteria,2GJ80@201174|Actinobacteria	201174|Actinobacteria	Q	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase,NAD_binding_8
HKD2_k127_2221931_1	365528.KB891223_gene1330	0.0001879	47.0	COG1249@1|root,COG1249@2|Bacteria,2GIXY@201174|Actinobacteria,4ERMW@85013|Frankiales	201174|Actinobacteria	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation	pdhD	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
HKD2_k127_2221931_0	298654.FraEuI1c_1771	1.415e-188	602.0	COG0260@1|root,COG0260@2|Bacteria,2GJRB@201174|Actinobacteria,4ERDZ@85013|Frankiales	201174|Actinobacteria	E	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	pepA	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17,Peptidase_M17_N
HKD2_k127_2233338_3	351607.Acel_2144	1.761e-31	137.0	COG0791@1|root,COG3883@1|root,COG0791@2|Bacteria,COG3883@2|Bacteria,2GIWB@201174|Actinobacteria,4ESXT@85013|Frankiales	201174|Actinobacteria	M	PFAM NLP P60 protein	-	-	-	ko:K21471	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	NLPC_P60
HKD2_k127_2233338_0	365528.KB891212_gene2263	1.304e-123	406.0	COG0053@1|root,COG0053@2|Bacteria,2GKSG@201174|Actinobacteria,4EU6E@85013|Frankiales	201174|Actinobacteria	P	cation diffusion facilitator family transporter	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,ZT_dimer
HKD2_k127_2233338_1	656024.FsymDg_1748	3.514e-110	374.0	28KB1@1|root,2Z9Y5@2|Bacteria,2GM37@201174|Actinobacteria,4EWN1@85013|Frankiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2233338_2	298654.FraEuI1c_4837	7.148e-33	128.0	2E4I7@1|root,32ZDA@2|Bacteria,2IQBB@201174|Actinobacteria,4ETBU@85013|Frankiales	201174|Actinobacteria	S	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2233338_4	1120936.KB907219_gene3148	4.282e-15	81.0	COG1024@1|root,COG1024@2|Bacteria,2GKC4@201174|Actinobacteria,4EGTG@85012|Streptosporangiales	201174|Actinobacteria	I	Enoyl-CoA hydratase/isomerase	echA	-	-	-	-	-	-	-	-	-	-	-	ECH_1
HKD2_k127_225127_0	1304865.JAGF01000001_gene3291	5.765e-235	747.0	COG2217@1|root,COG2217@2|Bacteria,2GIRF@201174|Actinobacteria,4F1XR@85016|Cellulomonadaceae	201174|Actinobacteria	P	E1-E2 ATPase	-	-	3.6.3.4,3.6.3.54	ko:K01533,ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,Hemerythrin,Hydrolase
HKD2_k127_225127_13	1169161.KB897722_gene4496	9.708e-20	100.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,2GMN4@201174|Actinobacteria	201174|Actinobacteria	G	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate	ppsA	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PPDK_N
HKD2_k127_225127_2	106370.Francci3_1486	6.363e-165	539.0	COG3850@1|root,COG3850@2|Bacteria,2GIWI@201174|Actinobacteria,4ESAF@85013|Frankiales	201174|Actinobacteria	T	GAF domain	devS	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HATPase_c_2,HisKA_3
HKD2_k127_225127_17	469371.Tbis_2498	0.0002932	45.0	COG1476@1|root,COG1476@2|Bacteria,2I6GU@201174|Actinobacteria,4EE5Z@85010|Pseudonocardiales	201174|Actinobacteria	K	TRANSCRIPTIONal	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_225127_9	469371.Tbis_2497	5.226e-74	254.0	COG0454@1|root,COG0456@2|Bacteria,2GN77@201174|Actinobacteria,4EB3N@85010|Pseudonocardiales	201174|Actinobacteria	K	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10
HKD2_k127_225127_6	1120949.KB903294_gene3588	2.437e-116	383.0	COG3387@1|root,COG3387@2|Bacteria,2GJAD@201174|Actinobacteria,4D8XJ@85008|Micromonosporales	201174|Actinobacteria	G	Glycoside hydrolase 15-related	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_15
HKD2_k127_225127_3	1120949.KB903294_gene3588	4.393e-155	511.0	COG3387@1|root,COG3387@2|Bacteria,2GJAD@201174|Actinobacteria,4D8XJ@85008|Micromonosporales	201174|Actinobacteria	G	Glycoside hydrolase 15-related	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_15
HKD2_k127_225127_8	298655.KI912266_gene5678	6.384e-78	267.0	2A84P@1|root,30X5E@2|Bacteria,2IN6P@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_225127_7	298655.KI912266_gene3504	8.76e-89	297.0	COG2197@1|root,COG2197@2|Bacteria,2GK4B@201174|Actinobacteria,4ESHE@85013|Frankiales	201174|Actinobacteria	T	Two component transcriptional regulator, LuxR family	-	-	-	ko:K07695	ko02020,map02020	M00482	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	GerE,Response_reg
HKD2_k127_225127_12	1150398.JIBJ01000003_gene1905	2.966e-20	99.0	COG1042@1|root,COG1670@1|root,COG1042@2|Bacteria,COG1670@2|Bacteria,2GKN1@201174|Actinobacteria,1W87A@1268|Micrococcaceae	201174|Actinobacteria	CJ	ATP-grasp domain	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig
HKD2_k127_225127_14	1121926.AXWO01000020_gene2027	8.032e-19	94.0	COG0589@1|root,COG0589@2|Bacteria,2IQPQ@201174|Actinobacteria,4F0C4@85014|Glycomycetales	201174|Actinobacteria	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD2_k127_225127_5	1089544.KB912942_gene4820	3.618e-128	419.0	COG0474@1|root,COG0474@2|Bacteria,2GJJC@201174|Actinobacteria,4E035@85010|Pseudonocardiales	201174|Actinobacteria	P	Cation transporter/ATPase, N-terminus	-	-	3.6.3.2	ko:K01531	-	-	-	-	ko00000,ko01000	3.A.3.4	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
HKD2_k127_225127_1	1157634.KB912956_gene1935	7.67e-199	669.0	COG0474@1|root,COG0474@2|Bacteria,2GJJC@201174|Actinobacteria	201174|Actinobacteria	P	ATPase P-type (Transporting), HAD superfamily, subfamily IC	-	-	3.6.3.2	ko:K01531	-	-	-	-	ko00000,ko01000	3.A.3.4	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
HKD2_k127_225127_11	710111.FraQA3DRAFT_3340	1.437e-22	103.0	COG1136@1|root,COG1136@2|Bacteria,2GJQV@201174|Actinobacteria	201174|Actinobacteria	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD2_k127_225127_10	365528.KB891210_gene2136	1.164e-66	258.0	COG1136@1|root,COG1136@2|Bacteria,2GJQV@201174|Actinobacteria	201174|Actinobacteria	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD2_k127_225127_4	710111.FraQA3DRAFT_3341	1.413e-133	434.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HKD2_k127_2269260_0	106370.Francci3_3562	0.0	1269.0	COG0532@1|root,COG0532@2|Bacteria,2GKPH@201174|Actinobacteria,4ERI2@85013|Frankiales	201174|Actinobacteria	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,IF-2,IF2_N
HKD2_k127_2269260_2	365528.KB891241_gene6182	9.778e-35	138.0	COG1550@1|root,COG1550@2|Bacteria,2IQW4@201174|Actinobacteria,4ET2E@85013|Frankiales	201174|Actinobacteria	S	Protein of unknown function (DUF503)	-	-	-	ko:K09764	-	-	-	-	ko00000	-	-	-	DUF503
HKD2_k127_2269260_1	298655.KI912267_gene6672	6.01e-62	216.0	COG0858@1|root,COG0858@2|Bacteria,2IKXP@201174|Actinobacteria,4ESSH@85013|Frankiales	201174|Actinobacteria	J	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA	rbfA	-	-	ko:K02834	-	-	-	-	ko00000,ko03009	-	-	-	RBFA
HKD2_k127_2269260_3	298654.FraEuI1c_1105	2.233e-15	85.0	COG0618@1|root,COG0618@2|Bacteria,2GN9Z@201174|Actinobacteria,4ESKW@85013|Frankiales	201174|Actinobacteria	S	PFAM phosphoesterase RecJ domain protein	nrnA	GO:0008150,GO:0040007	3.1.13.3,3.1.3.7	ko:K06881	ko00920,ko01100,ko01120,map00920,map01100,map01120	-	R00188,R00508	RC00078	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
HKD2_k127_231545_1	1120950.KB892756_gene6676	1.249e-18	99.0	2DT0G@1|root,33I5Y@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_231545_0	656024.FsymDg_2815	1.914e-122	398.0	COG0682@1|root,COG0682@2|Bacteria,2GKSS@201174|Actinobacteria,4ERW1@85013|Frankiales	201174|Actinobacteria	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	lgt	-	-	-	-	-	-	-	-	-	-	-	LGT
HKD2_k127_231801_7	1380370.JIBA01000013_gene1198	1.796e-24	104.0	28J4D@1|root,2Z90C@2|Bacteria,2GJYC@201174|Actinobacteria,4FK0K@85021|Intrasporangiaceae	201174|Actinobacteria	S	Protein of unknown function (DUF3710)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3710
HKD2_k127_231801_6	675635.Psed_3059	1.038e-26	121.0	COG2021@1|root,COG2021@2|Bacteria,2I2RU@201174|Actinobacteria	201174|Actinobacteria	E	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_231801_5	365528.KB891102_gene4521	1.838e-38	160.0	COG1200@1|root,COG1200@2|Bacteria,2IHRX@201174|Actinobacteria,4ETC1@85013|Frankiales	201174|Actinobacteria	KL	Nucleic acid binding, OB-fold, tRNA	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_231801_4	106370.Francci3_1321	8.242e-62	222.0	2AVV0@1|root,31MNQ@2|Bacteria,2GJKP@201174|Actinobacteria,4ET2Z@85013|Frankiales	201174|Actinobacteria	S	Protein of unknown function (DUF3159)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3159
HKD2_k127_231801_3	365528.KB891102_gene4519	8.954e-81	305.0	COG0569@1|root,COG0569@2|Bacteria,2GKB9@201174|Actinobacteria,4ERNZ@85013|Frankiales	201174|Actinobacteria	P	PFAM TrkA-N domain protein	ceoC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
HKD2_k127_231801_2	710111.FraQA3DRAFT_2967	1.376e-95	317.0	COG0569@1|root,COG0569@2|Bacteria,2GK4N@201174|Actinobacteria,4ESF8@85013|Frankiales	201174|Actinobacteria	P	PFAM TrkA-N domain protein	ceoB	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
HKD2_k127_231801_0	222534.KB893671_gene3187	1.646e-309	960.0	COG0531@1|root,COG0531@2|Bacteria,2GK5V@201174|Actinobacteria,4ERRM@85013|Frankiales	201174|Actinobacteria	E	Amino acid permease	ydaO	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
HKD2_k127_231801_1	1003195.SCAT_4645	3.694e-247	785.0	COG0531@1|root,COG0531@2|Bacteria,2GK5V@201174|Actinobacteria	201174|Actinobacteria	E	amino acid	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
HKD2_k127_231801_8	40571.JOEA01000048_gene5884	7.214e-16	83.0	2F1W4@1|root,33UVW@2|Bacteria,2GK04@201174|Actinobacteria,4E15Q@85010|Pseudonocardiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2341092_4	656024.FsymDg_3827	8.475e-07	53.0	COG1193@1|root,COG1193@2|Bacteria	2|Bacteria	L	negative regulation of DNA recombination	mutS2	-	-	ko:K07456	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_V,Smr
HKD2_k127_2341092_2	2002.JOEQ01000037_gene4331	9.154e-90	310.0	COG0628@1|root,COG0628@2|Bacteria,2GN4Y@201174|Actinobacteria,4EFTZ@85012|Streptosporangiales	201174|Actinobacteria	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
HKD2_k127_2341092_3	1122611.KB903996_gene7554	9.7e-71	262.0	COG0596@1|root,COG0596@2|Bacteria,2GNFU@201174|Actinobacteria,4EFFN@85012|Streptosporangiales	201174|Actinobacteria	S	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_4,Abhydrolase_6
HKD2_k127_2341092_1	1122611.KB903996_gene7555	1.034e-91	319.0	COG1028@1|root,COG1028@2|Bacteria,2GK20@201174|Actinobacteria,4EP82@85012|Streptosporangiales	201174|Actinobacteria	IQ	KR domain	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HKD2_k127_2341092_0	479432.Sros_1691	1.071e-93	313.0	COG2945@1|root,COG2945@2|Bacteria,2GP8G@201174|Actinobacteria,4EHK6@85012|Streptosporangiales	201174|Actinobacteria	S	hydrolase of the alpha beta	-	-	-	ko:K07018	-	-	-	-	ko00000	-	-	-	Abhydrolase_6
HKD2_k127_236738_1	298653.Franean1_5667	8.092e-23	101.0	COG0683@1|root,COG0683@2|Bacteria,2GMDG@201174|Actinobacteria	201174|Actinobacteria	E	Periplasmic binding protein	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
HKD2_k127_236738_3	656024.FsymDg_1224	4.366e-12	74.0	COG1846@1|root,COG1846@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	-	-	3.6.4.12	ko:K03655,ko:K07506	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03000,ko03400	-	-	-	Fic,HATPase_c,HTH_24,HTH_36,Phg_2220_C,ROK
HKD2_k127_236738_0	314278.NB231_00235	8.056e-91	310.0	COG0451@1|root,COG0451@2|Bacteria,1MW32@1224|Proteobacteria,1SYQK@1236|Gammaproteobacteria,1X0BB@135613|Chromatiales	135613|Chromatiales	M	NmrA-like family	-	-	1.1.1.219	ko:K00091	-	-	-	-	ko00000,ko01000	-	-	-	Epimerase
HKD2_k127_236738_2	76114.ebA6565	1.782e-19	89.0	COG0859@1|root,COG0859@2|Bacteria,1PM09@1224|Proteobacteria,2VIX8@28216|Betaproteobacteria	28216|Betaproteobacteria	H	Glycosyltransferase family 9 (heptosyltransferase)	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_9
HKD2_k127_244623_0	500153.JOEK01000008_gene2485	1.238e-109	365.0	COG1609@1|root,COG1609@2|Bacteria,2GJBJ@201174|Actinobacteria	201174|Actinobacteria	K	lacI family	-	-	-	-	-	-	-	-	-	-	-	-	LacI,Peripla_BP_3
HKD2_k127_244623_1	1894.JOER01000046_gene4583	6.219e-61	225.0	COG1621@1|root,COG1621@2|Bacteria,2H3S0@201174|Actinobacteria	201174|Actinobacteria	G	Glycosyl hydrolase family 32	-	-	3.2.1.26	ko:K01193	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00801,R00802,R02410,R03635,R03921,R06088	RC00028,RC00077	ko00000,ko00001,ko01000	-	GH32	-	Glyco_hydro_32N
HKD2_k127_248648_3	656024.FsymDg_0989	1.523e-125	421.0	COG0508@1|root,COG0567@1|root,COG0508@2|Bacteria,COG0567@2|Bacteria,2GIU6@201174|Actinobacteria,4ES2Q@85013|Frankiales	201174|Actinobacteria	C	TIGRFAM 2-oxoglutarate dehydrogenase, E1	kgd	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006103,GO:0008150,GO:0008152,GO:0008683,GO:0009055,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016740,GO:0016744,GO:0016829,GO:0016830,GO:0016831,GO:0016999,GO:0017144,GO:0019752,GO:0022900,GO:0030312,GO:0032991,GO:0040007,GO:0043167,GO:0043169,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045254,GO:0045333,GO:0046872,GO:0050439,GO:0051186,GO:0055114,GO:0071704,GO:0071944,GO:0072350,GO:1902494,GO:1990204,GO:1990234	1.2.4.2,4.1.1.71	ko:K00164,ko:K01616	ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R00621,R01933,R01940,R03316,R08549	RC00004,RC00027,RC00627,RC02743,RC02833,RC02883	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv1248c	2-oxoacid_dh,2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr
HKD2_k127_248648_5	266117.Rxyl_2410	4.974e-86	292.0	COG0145@1|root,COG0145@2|Bacteria,2GIYE@201174|Actinobacteria,4CPCB@84995|Rubrobacteria	84995|Rubrobacteria	EQ	Hydantoinase oxoprolinase	-	-	3.5.2.14	ko:K01473	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydant_A_N,Hydantoinase_A
HKD2_k127_248648_1	656024.FsymDg_0990	1.745e-170	544.0	COG0145@1|root,COG0145@2|Bacteria,2GIYE@201174|Actinobacteria	201174|Actinobacteria	EQ	PFAM Hydantoinase oxoprolinase	-	-	3.5.2.14	ko:K01473	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydant_A_N,Hydantoinase_A,Hydantoinase_B
HKD2_k127_248648_2	1122611.KB903945_gene1391	2.066e-159	514.0	COG0675@1|root,COG0675@2|Bacteria,2GM6K@201174|Actinobacteria,4ENI8@85012|Streptosporangiales	201174|Actinobacteria	L	Putative transposase DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_OrfB_IS605,OrfB_IS605,OrfB_Zn_ribbon
HKD2_k127_248648_10	1122611.KB903978_gene3324	0.0001065	51.0	COG0675@1|root,COG0675@2|Bacteria,2GM6K@201174|Actinobacteria,4ENI8@85012|Streptosporangiales	201174|Actinobacteria	L	Putative transposase DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_OrfB_IS605,OrfB_IS605,OrfB_Zn_ribbon
HKD2_k127_248648_6	106370.Francci3_2684	1.136e-51	186.0	COG1943@1|root,COG1943@2|Bacteria,2IGK0@201174|Actinobacteria	201174|Actinobacteria	L	PFAM transposase IS200-family protein	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
HKD2_k127_248648_0	298654.FraEuI1c_6367	9.181e-252	786.0	COG0146@1|root,COG0146@2|Bacteria,2HWA8@201174|Actinobacteria,4EXCJ@85013|Frankiales	201174|Actinobacteria	EQ	Hydantoinase B/oxoprolinase	-	-	3.5.2.14	ko:K01474	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydantoinase_B
HKD2_k127_248648_7	298654.FraEuI1c_1908	8.444e-43	166.0	COG4113@1|root,COG4113@2|Bacteria,2GR4U@201174|Actinobacteria,4ETCS@85013|Frankiales	201174|Actinobacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	-	-	-	-	-	-	-	-	-	PIN
HKD2_k127_248648_9	298654.FraEuI1c_1909	3.027e-24	103.0	2DR8X@1|root,33AQM@2|Bacteria,2GXTC@201174|Actinobacteria,4EWM3@85013|Frankiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_248648_8	1120948.KB903243_gene2363	3.116e-34	138.0	29ZQE@1|root,30MR6@2|Bacteria,2HBXP@201174|Actinobacteria,4EDGQ@85010|Pseudonocardiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_248648_4	298653.Franean1_0163	4.74e-115	385.0	COG0455@1|root,COG0455@2|Bacteria,2GMK0@201174|Actinobacteria	201174|Actinobacteria	D	Involved in chromosome	espI	GO:0002790,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009405,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0032940,GO:0033036,GO:0042886,GO:0044315,GO:0044419,GO:0044464,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0051704,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944	-	-	-	-	-	-	-	-	-	-	AAA_31,CbiA
HKD2_k127_2554462_13	298655.KI912266_gene94	4.855e-17	86.0	COG1186@1|root,COG1186@2|Bacteria,2GJ0F@201174|Actinobacteria,4ERJ3@85013|Frankiales	201174|Actinobacteria	J	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA	prfB	-	-	ko:K02836	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
HKD2_k127_2554462_6	526225.Gobs_3300	7.395e-97	323.0	COG1277@1|root,COG1277@2|Bacteria,2GP6D@201174|Actinobacteria,4ESJR@85013|Frankiales	201174|Actinobacteria	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2,ABC2_membrane_4
HKD2_k127_2554462_5	543632.JOJL01000027_gene2690	7.392e-117	387.0	COG1131@1|root,COG1131@2|Bacteria,2GN8P@201174|Actinobacteria	201174|Actinobacteria	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD2_k127_2554462_10	367299.JOEE01000002_gene2496	3.595e-48	190.0	COG3026@1|root,COG3026@2|Bacteria,2I3RC@201174|Actinobacteria	201174|Actinobacteria	T	antisigma factor binding	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2554462_2	58123.JOFJ01000012_gene5379	1.005e-126	424.0	COG0726@1|root,COG3591@1|root,COG0726@2|Bacteria,COG3591@2|Bacteria	2|Bacteria	E	Belongs to the peptidase S1B family	-	-	3.2.1.14,3.5.1.104	ko:K01183,ko:K03791,ko:K22278	ko00520,ko01100,map00520,map01100	-	R01206,R02334	RC00467	ko00000,ko00001,ko01000	-	GH18,GH19	-	LysM,Polysacc_deac_1,Trypsin,Trypsin_2
HKD2_k127_2554462_11	326424.FRAAL1349	2.462e-41	164.0	2EBSZ@1|root,335SP@2|Bacteria,2GYMD@201174|Actinobacteria,4EWWB@85013|Frankiales	201174|Actinobacteria	S	Putative Flp pilus-assembly TadE/G-like	-	-	-	-	-	-	-	-	-	-	-	-	Tad
HKD2_k127_2554462_8	106370.Francci3_0784	6.456e-50	183.0	2E9Y4@1|root,3343S@2|Bacteria,2GVJE@201174|Actinobacteria,4ETE7@85013|Frankiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2554462_14	326424.FRAAL1323	1.563e-16	86.0	2DNWX@1|root,32ZKV@2|Bacteria,2HTN0@201174|Actinobacteria,4ETKY@85013|Frankiales	201174|Actinobacteria	S	TadE-like protein	-	-	-	-	-	-	-	-	-	-	-	-	TadE
HKD2_k127_2554462_15	298654.FraEuI1c_6027	2.403e-14	75.0	2EG89@1|root,33A03@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2554462_4	106370.Francci3_0781	3.277e-121	405.0	COG2064@1|root,COG2064@2|Bacteria,2GK7B@201174|Actinobacteria,4ESC6@85013|Frankiales	201174|Actinobacteria	NU	Type II secretion system	-	-	-	ko:K12511	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
HKD2_k127_2554462_3	656024.FsymDg_1121	3.099e-126	409.0	COG2064@1|root,COG2064@2|Bacteria,2GKMW@201174|Actinobacteria,4ESFS@85013|Frankiales	201174|Actinobacteria	NU	Type II secretion system	-	-	-	ko:K12510	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
HKD2_k127_2554462_1	298655.KI912266_gene105	3.595e-211	667.0	COG4962@1|root,COG4962@2|Bacteria,2GKKJ@201174|Actinobacteria,4ERKI@85013|Frankiales	201174|Actinobacteria	U	type II secretion system protein E	cpaF	-	-	ko:K02283	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
HKD2_k127_2554462_12	1449068.JMLQ01000007_gene2625	1.777e-21	98.0	2E301@1|root,32Y0K@2|Bacteria,2GQTM@201174|Actinobacteria,4G484@85025|Nocardiaceae	201174|Actinobacteria	S	Protein of unknown function (DUF3072)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3072
HKD2_k127_2554462_16	656024.FsymDg_1119	2.495e-06	58.0	COG3743@1|root,COG3743@2|Bacteria,2I8R1@201174|Actinobacteria	201174|Actinobacteria	V	rRNA binding	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2554462_0	1179773.BN6_12850	3.239e-259	812.0	COG1012@1|root,COG1012@2|Bacteria,2GJZE@201174|Actinobacteria,4DX9P@85010|Pseudonocardiales	201174|Actinobacteria	C	PFAM Aldehyde dehydrogenase	-	-	1.2.1.88	ko:K00294	ko00250,ko00330,ko01100,map00250,map00330,map01100	-	R00245,R00707,R00708,R04444,R04445,R05051	RC00080,RC00216,RC00242,RC00255	ko00000,ko00001,ko01000	-	-	-	Aldedh
HKD2_k127_2554462_9	298654.FraEuI1c_6033	7.781e-49	179.0	2DRWJ@1|root,32URV@2|Bacteria,2IFAY@201174|Actinobacteria,4ET0Q@85013|Frankiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2554462_7	326424.FRAAL1315	2.109e-77	267.0	COG1752@1|root,COG1752@2|Bacteria,2IB0F@201174|Actinobacteria,4ET56@85013|Frankiales	201174|Actinobacteria	S	Patatin-like phospholipase	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
HKD2_k127_2557315_3	365528.KB891102_gene4578	3.679e-67	234.0	COG1530@1|root,COG1530@2|Bacteria,2GMM5@201174|Actinobacteria,4ERY4@85013|Frankiales	201174|Actinobacteria	J	ribonuclease, Rne Rng family	rne	-	3.1.26.12	ko:K08300,ko:K08301	ko03018,map03018	M00394	-	-	ko00000,ko00001,ko00002,ko01000,ko03009,ko03019	-	-	-	IF2_N,RNase_E_G,S1
HKD2_k127_2557315_5	1120950.KB892766_gene5094	5.806e-29	134.0	COG0261@1|root,COG0261@2|Bacteria,2IQ9A@201174|Actinobacteria,4DRJ6@85009|Propionibacteriales	201174|Actinobacteria	J	This protein binds to 23S rRNA in the presence of protein L20	rplU	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	-	ko:K02888	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L21p
HKD2_k127_2557315_4	656024.FsymDg_1534	5.402e-41	152.0	COG0211@1|root,COG0211@2|Bacteria,2IQDI@201174|Actinobacteria,4ESYQ@85013|Frankiales	201174|Actinobacteria	J	Belongs to the bacterial ribosomal protein bL27 family	rpmA	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0008150,GO:0015934,GO:0016020,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071944,GO:1990904	-	ko:K02899	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27
HKD2_k127_2557315_0	106370.Francci3_1222	4.787e-217	694.0	COG0536@1|root,COG0536@2|Bacteria,2GISB@201174|Actinobacteria,4ES3D@85013|Frankiales	201174|Actinobacteria	S	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control	obg	GO:0000287,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016310,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0019538,GO:0032991,GO:0036211,GO:0040007,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046777,GO:0046872,GO:0071704,GO:0071944,GO:1901564,GO:1990904	-	ko:K03979	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	DUF1967,GTP1_OBG,MMR_HSR1
HKD2_k127_2557315_2	656024.FsymDg_1536	4.487e-160	535.0	COG0263@1|root,COG0263@2|Bacteria,2GM8U@201174|Actinobacteria,4ERBW@85013|Frankiales	201174|Actinobacteria	E	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate	proB	GO:0003674,GO:0003824,GO:0004349,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0018130,GO:0019202,GO:0019752,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.2.11	ko:K00931	ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230	M00015	R00239	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,PUA
HKD2_k127_2557315_1	365528.KB891102_gene4572	1.274e-183	582.0	COG0014@1|root,COG0014@2|Bacteria,2GISA@201174|Actinobacteria,4ERK4@85013|Frankiales	201174|Actinobacteria	E	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate	proA	GO:0003674,GO:0003824,GO:0004350,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016620,GO:0016903,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0071944	1.2.1.41	ko:K00147	ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230	M00015	R03313	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv2427c	Aldedh
HKD2_k127_2564910_4	1961.JOAK01000041_gene4434	3.637e-89	303.0	COG2172@1|root,COG2172@2|Bacteria,2GKU6@201174|Actinobacteria	201174|Actinobacteria	T	anti-sigma regulatory factor	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c_2,MEDS
HKD2_k127_2564910_10	405948.SACE_5348	0.0001157	47.0	COG0412@1|root,COG0412@2|Bacteria,2GNWB@201174|Actinobacteria,4DZTQ@85010|Pseudonocardiales	201174|Actinobacteria	Q	Dienelactone hydrolase family	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
HKD2_k127_2564910_6	136273.GY22_06920	8.544e-85	285.0	COG0412@1|root,COG0412@2|Bacteria,2GNWB@201174|Actinobacteria,1W9FM@1268|Micrococcaceae	201174|Actinobacteria	Q	Dienelactone hydrolase family	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
HKD2_k127_2564910_1	1297742.A176_07100	1.373e-149	482.0	COG1454@1|root,COG1454@2|Bacteria,1MVPH@1224|Proteobacteria,42NP2@68525|delta/epsilon subdivisions,2WIY2@28221|Deltaproteobacteria,2YUJC@29|Myxococcales	28221|Deltaproteobacteria	C	Iron-containing alcohol dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Fe-ADH
HKD2_k127_2564910_7	448385.sce1170	2.318e-42	163.0	COG1359@1|root,COG1359@2|Bacteria,1RI7W@1224|Proteobacteria,42Y4G@68525|delta/epsilon subdivisions,2WTC4@28221|Deltaproteobacteria,2YV68@29|Myxococcales	28221|Deltaproteobacteria	C	Antibiotic biosynthesis monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	ABM
HKD2_k127_2564910_3	298654.FraEuI1c_2450	7.272e-97	349.0	2DF97@1|root,2ZQZA@2|Bacteria	2|Bacteria	S	Glycosyltransferase family 87	-	-	-	-	-	-	-	-	-	-	-	-	GT87
HKD2_k127_2564910_0	298654.FraEuI1c_0426	2.734e-186	588.0	COG2268@1|root,COG2268@2|Bacteria,2GK9I@201174|Actinobacteria	201174|Actinobacteria	S	PFAM Band 7 protein	-	-	-	-	-	-	-	-	-	-	-	-	Band_7,Flot
HKD2_k127_2564910_8	298654.FraEuI1c_0425	2.541e-28	118.0	2CBII@1|root,3323U@2|Bacteria,2IQGY@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2564910_5	471852.Tcur_3711	4.802e-87	302.0	COG2135@1|root,COG2135@2|Bacteria,2GKY8@201174|Actinobacteria,4EH5H@85012|Streptosporangiales	201174|Actinobacteria	S	SOS response associated peptidase (SRAP)	-	-	-	-	-	-	-	-	-	-	-	-	SRAP
HKD2_k127_2564910_2	525904.Tter_2056	1.118e-121	399.0	COG1063@1|root,COG1063@2|Bacteria,2NPFX@2323|unclassified Bacteria	2|Bacteria	E	Glucose dehydrogenase C-terminus	gutB_1	-	1.1.1.14	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014	R00875,R01896	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
HKD2_k127_2570985_1	656024.FsymDg_3270	4.065e-191	600.0	COG0165@1|root,COG0165@2|Bacteria,2GJ2A@201174|Actinobacteria,4ES14@85013|Frankiales	201174|Actinobacteria	E	argininosuccinate lyase	argH	GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0030312,GO:0040007,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.3.2.1	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01086	RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ASL_C2,Lyase_1
HKD2_k127_2570985_0	656024.FsymDg_3271	1.797e-220	698.0	COG0137@1|root,COG0137@2|Bacteria,2GK96@201174|Actinobacteria,4ERIJ@85013|Frankiales	201174|Actinobacteria	E	Belongs to the argininosuccinate synthase family. Type 1 subfamily	argG	GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016020,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0040007,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0071944,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iNJ661.Rv1658	Arginosuc_synth
HKD2_k127_2570985_4	298655.KI912267_gene7515	2.866e-61	221.0	COG1438@1|root,COG1438@2|Bacteria,2GKA5@201174|Actinobacteria,4ESWE@85013|Frankiales	201174|Actinobacteria	K	Regulates arginine biosynthesis genes	argR	GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032991,GO:0032993,GO:0043565,GO:0044212,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141	-	ko:K03402	-	-	-	-	ko00000,ko03000	-	-	-	Arg_repressor,Arg_repressor_C
HKD2_k127_2570985_3	710111.FraQA3DRAFT_6333	1.716e-159	506.0	COG0078@1|root,COG0078@2|Bacteria,2GJ6H@201174|Actinobacteria,4ERRI@85013|Frankiales	201174|Actinobacteria	E	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline	argF	GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0040007,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.1.3.3	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844	R01398	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
HKD2_k127_2570985_2	222534.KB893694_gene171	5.52e-174	561.0	COG4992@1|root,COG4992@2|Bacteria,2GKE9@201174|Actinobacteria,4ES3J@85013|Frankiales	201174|Actinobacteria	E	TIGRFAM acetylornithine and succinylornithine	argD	GO:0003674,GO:0005488,GO:0005515,GO:0008144,GO:0008150,GO:0019842,GO:0030170,GO:0036094,GO:0040007,GO:0042802,GO:0043167,GO:0043168,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363	2.6.1.11,2.6.1.17	ko:K00821	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
HKD2_k127_2570985_5	222534.KB893694_gene170	2.524e-47	173.0	COG0548@1|root,COG0548@2|Bacteria,2GKDS@201174|Actinobacteria,4ERTB@85013|Frankiales	201174|Actinobacteria	E	Belongs to the acetylglutamate kinase family. ArgB subfamily	argB	GO:0003674,GO:0003824,GO:0003991,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016020,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0019752,GO:0030312,GO:0031406,GO:0034618,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.2.8	ko:K00930	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R02649	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase
HKD2_k127_2572970_7	1370121.AUWS01000004_gene3382	9.563e-67	237.0	COG1028@1|root,COG1028@2|Bacteria,2GM7N@201174|Actinobacteria,237TI@1762|Mycobacteriaceae	201174|Actinobacteria	IQ	short chain dehydrogenase	-	-	1.3.1.33	ko:K00218	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R03845,R06286	RC01008	ko00000,ko00001,ko01000	-	-	-	adh_short
HKD2_k127_2572970_15	103733.JNYO01000030_gene1358	2.641e-23	108.0	COG1309@1|root,COG1309@2|Bacteria,2IP31@201174|Actinobacteria,4E3KM@85010|Pseudonocardiales	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
HKD2_k127_2572970_5	367299.JOEE01000001_gene2068	1.347e-96	332.0	COG2172@1|root,COG2345@1|root,COG2172@2|Bacteria,COG2345@2|Bacteria,2IERP@201174|Actinobacteria,4FIG7@85021|Intrasporangiaceae	201174|Actinobacteria	KT	Histidine kinase-like ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c_2
HKD2_k127_2572970_0	219305.MCAG_02322	9.482e-225	728.0	COG1131@1|root,COG2936@1|root,COG1131@2|Bacteria,COG2936@2|Bacteria,2GN8P@201174|Actinobacteria,4DA34@85008|Micromonosporales	201174|Actinobacteria	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,PepX_C,Peptidase_S15
HKD2_k127_2572970_8	1120936.KB907214_gene4563	4.33e-64	229.0	COG1277@1|root,COG1277@2|Bacteria,2GP6D@201174|Actinobacteria,4EH6E@85012|Streptosporangiales	201174|Actinobacteria	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2,ABC2_membrane_4
HKD2_k127_2572970_6	909613.UO65_6217	1.165e-83	289.0	COG4221@1|root,COG4221@2|Bacteria,2GMGQ@201174|Actinobacteria,4DYP8@85010|Pseudonocardiales	201174|Actinobacteria	S	Short-chain alcohol dehydrogenase	sdh	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	1.1.1.381	ko:K16066	ko00240,ko00260,ko01100,map00240,map00260,map01100	-	R09289,R10851,R10852	RC00087,RC00525,RC03288	ko00000,ko00001,ko01000	-	-	-	adh_short
HKD2_k127_2572970_16	469383.Cwoe_2966	6.937e-18	85.0	COG4118@1|root,COG4118@2|Bacteria,2HRUG@201174|Actinobacteria,4CTXW@84995|Rubrobacteria	84995|Rubrobacteria	D	Antitoxin component of a toxin-antitoxin (TA) module	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
HKD2_k127_2572970_14	1121924.ATWH01000024_gene1052	1.039e-24	108.0	COG1848@1|root,COG1848@2|Bacteria,2GRA5@201174|Actinobacteria,4FSPB@85023|Microbacteriaceae	201174|Actinobacteria	S	PIN domain	-	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040008,GO:0044464,GO:0045926,GO:0048519,GO:0050789,GO:0065007,GO:0071944	-	ko:K07064	-	-	-	-	ko00000	-	-	-	PIN
HKD2_k127_2572970_4	656024.FsymDg_1234	3.905e-116	379.0	COG1051@1|root,COG4111@1|root,COG1051@2|Bacteria,COG4111@2|Bacteria,2GNMT@201174|Actinobacteria,4EV0Y@85013|Frankiales	201174|Actinobacteria	F	PFAM NUDIX hydrolase	-	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX
HKD2_k127_2572970_3	1206741.BAFX01000196_gene3610	1.844e-124	417.0	COG0477@1|root,COG2814@2|Bacteria,2I5AX@201174|Actinobacteria,4FX6Y@85025|Nocardiaceae	201174|Actinobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
HKD2_k127_2572970_2	2002.JOEQ01000004_gene2696	7.875e-168	539.0	COG1488@1|root,COG1488@2|Bacteria,2GJAT@201174|Actinobacteria,4EGMC@85012|Streptosporangiales	201174|Actinobacteria	H	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP	pncB	-	6.3.4.21	ko:K00763	ko00760,ko01100,map00760,map01100	-	R01724	RC00033	ko00000,ko00001,ko01000	-	-	-	NAPRTase
HKD2_k127_2572970_12	710111.FraQA3DRAFT_3480	1.197e-40	153.0	COG2127@1|root,COG2127@2|Bacteria,2IQ3Z@201174|Actinobacteria,4ESZD@85013|Frankiales	201174|Actinobacteria	S	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation	clpS	-	-	ko:K06891	-	-	-	-	ko00000	-	-	-	ClpS
HKD2_k127_2572970_11	326424.FRAAL1497	6.564e-50	186.0	2E4AX@1|root,32Z6K@2|Bacteria,2GW4T@201174|Actinobacteria,4ET8U@85013|Frankiales	201174|Actinobacteria	S	Domain of unknown function (DUF2017)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2017
HKD2_k127_2572970_10	710111.FraQA3DRAFT_3478	1.942e-59	224.0	COG1310@1|root,COG1310@2|Bacteria,2IFB5@201174|Actinobacteria,4ESP5@85013|Frankiales	201174|Actinobacteria	S	PFAM Mov34 MPN PAD-1 family	mec	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006508,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0008270,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016787,GO:0019344,GO:0019538,GO:0019752,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0046914,GO:0070011,GO:0071704,GO:0140096,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	3.13.1.6	ko:K21140	ko04122,map04122	-	R11524	RC00064,RC00090	ko00000,ko00001,ko01000	-	-	-	Prok-JAB
HKD2_k127_2572970_13	369723.Strop_1101	3.141e-37	158.0	COG1977@1|root,COG1977@2|Bacteria,2IQBT@201174|Actinobacteria,4DE3Z@85008|Micromonosporales	201174|Actinobacteria	H	ThiS family	cysO	GO:0000096,GO:0000097,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0019344,GO:0019752,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	-	ko:K03636	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
HKD2_k127_2572970_1	298654.FraEuI1c_5851	4.374e-180	573.0	COG0031@1|root,COG0031@2|Bacteria,2GIXE@201174|Actinobacteria,4ERDA@85013|Frankiales	201174|Actinobacteria	E	Cysteine synthase	cysM	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019344,GO:0019752,GO:0019842,GO:0030170,GO:0032991,GO:0033847,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.5.1.113	ko:K21148	ko04122,map04122	-	R10610	RC03225	ko00000,ko00001,ko01000	-	-	-	PALP
HKD2_k127_2572970_9	1386089.N865_05785	7.108e-61	220.0	COG1835@1|root,COG1835@2|Bacteria,2GKUS@201174|Actinobacteria	201174|Actinobacteria	I	Acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
HKD2_k127_2583748_1	106370.Francci3_3771	2.651e-47	170.0	COG0128@1|root,COG0128@2|Bacteria,2GJKX@201174|Actinobacteria,4ERSF@85013|Frankiales	201174|Actinobacteria	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	GO:0003674,GO:0003824,GO:0003866,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016765,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0071704,GO:0071944,GO:1901576	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	EPSP_synthase
HKD2_k127_2583748_0	656024.FsymDg_0961	7.219e-142	460.0	COG1162@1|root,COG1162@2|Bacteria,2GJ37@201174|Actinobacteria,4ES5S@85013|Frankiales	201174|Actinobacteria	S	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit	rsgA	-	3.1.3.100	ko:K06949	ko00730,ko01100,map00730,map01100	-	R00615,R02135	RC00002,RC00017	ko00000,ko00001,ko01000,ko03009	-	-	-	RsgA_GTPase
HKD2_k127_2583748_2	479432.Sros_6522	1.564e-31	127.0	COG0208@1|root,COG0208@2|Bacteria,2GJKZ@201174|Actinobacteria,4EFU2@85012|Streptosporangiales	201174|Actinobacteria	F	P-aminobenzoate N-oxygenase AurF	-	-	-	-	-	-	-	-	-	-	-	-	AurF
HKD2_k127_2583910_15	1385520.N802_05040	1.674e-30	125.0	2CNK3@1|root,32SH9@2|Bacteria,2IRH1@201174|Actinobacteria	201174|Actinobacteria	S	Protein of Unknown function (DUF2784)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2784
HKD2_k127_2583910_11	1283283.ATXA01000016_gene28	2.264e-59	220.0	COG0346@1|root,COG0346@2|Bacteria,2IFUM@201174|Actinobacteria	201174|Actinobacteria	E	glyoxalase bleomycin resistance protein dioxygenase	cadI	GO:0008150,GO:0010035,GO:0010038,GO:0042221,GO:0046686,GO:0050896	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HKD2_k127_2583910_12	1146883.BLASA_1857	3.433e-45	166.0	COG0640@1|root,COG0640@2|Bacteria,2IQDH@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	-	-	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	HTH_5
HKD2_k127_2583910_22	83332.Rv3321c	7.886e-14	72.0	2DSQK@1|root,33H2H@2|Bacteria,2H8IS@201174|Actinobacteria,23EB7@1762|Mycobacteriaceae	201174|Actinobacteria	-	-	-	GO:0008150,GO:0009605,GO:0009607,GO:0043207,GO:0044403,GO:0044419,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0075136	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2583910_1	1155718.KB891914_gene1449	2.221e-175	557.0	COG0441@1|root,COG0441@2|Bacteria,2GNDW@201174|Actinobacteria	201174|Actinobacteria	J	threonine--tRNA ligase	thrS2	-	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b
HKD2_k127_2583910_18	1048339.KB913029_gene4857	1.77e-27	121.0	COG4941@1|root,COG4941@2|Bacteria,2GJ36@201174|Actinobacteria,4ES50@85013|Frankiales	201174|Actinobacteria	K	TIGRFAM RNA polymerase sigma factor, sigma-70 family	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD2_k127_2583910_20	1449048.JQKU01000019_gene4103	2.326e-15	89.0	COG3795@1|root,COG3795@2|Bacteria,2IKRD@201174|Actinobacteria,23F1K@1762|Mycobacteriaceae	201174|Actinobacteria	S	YCII-related domain	-	-	-	-	-	-	-	-	-	-	-	-	YCII
HKD2_k127_2583910_7	469371.Tbis_2085	1.349e-79	295.0	COG2909@1|root,COG2909@2|Bacteria,2GJXF@201174|Actinobacteria,4DYUD@85010|Pseudonocardiales	201174|Actinobacteria	K	luxR family	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GerE
HKD2_k127_2583910_21	1146883.BLASA_3958	4.509e-15	77.0	COG2337@1|root,COG2337@2|Bacteria,2IICB@201174|Actinobacteria	201174|Actinobacteria	T	PemK-like, MazF-like toxin of type II toxin-antitoxin system	-	-	-	ko:K07171	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PemK_toxin
HKD2_k127_2583910_17	1089553.Tph_c21870	7.082e-30	131.0	COG1073@1|root,COG1073@2|Bacteria	2|Bacteria	S	thiolester hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6,Hydrolase_4
HKD2_k127_2583910_24	644966.Tmar_0683	2.359e-08	65.0	COG2021@1|root,COG2021@2|Bacteria,1UMHR@1239|Firmicutes,25GIJ@186801|Clostridia,3WDQ0@538999|Clostridiales incertae sedis	186801|Clostridia	E	TIGRFAM proline-specific peptidases, Bacillus coagulans-type subfamily	-	-	3.4.11.5	ko:K01259	ko00330,map00330	-	R00135	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Abhydrolase_1
HKD2_k127_2583910_19	1380347.JNII01000005_gene3645	4.88e-23	114.0	COG1247@1|root,COG1247@2|Bacteria	2|Bacteria	M	phosphinothricin N-acetyltransferase activity	-	-	-	ko:K03827	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_1,Acetyltransf_10
HKD2_k127_2583910_14	526225.Gobs_4976	4.945e-31	141.0	2C9IE@1|root,31AT3@2|Bacteria,2IM6M@201174|Actinobacteria	201174|Actinobacteria	S	Domain of unknown function (DUF4383)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4383
HKD2_k127_2583910_25	1206739.BAGJ01000273_gene4117	2.837e-05	57.0	2DBF5@1|root,2Z8WM@2|Bacteria,2GNTC@201174|Actinobacteria,4FVTK@85025|Nocardiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2583910_3	1122611.KB903967_gene5148	2.921e-123	404.0	COG1028@1|root,COG1028@2|Bacteria,2GJU1@201174|Actinobacteria,4EG8V@85012|Streptosporangiales	201174|Actinobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HKD2_k127_2583910_10	1122138.AQUZ01000024_gene7649	3.11e-60	220.0	COG0204@1|root,COG0204@2|Bacteria,2GKVA@201174|Actinobacteria,4DQUS@85009|Propionibacteriales	201174|Actinobacteria	I	Phosphate acyltransferases	plsC2	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
HKD2_k127_2583910_4	710111.FraQA3DRAFT_2935	2.232e-100	332.0	COG1583@1|root,COG1583@2|Bacteria,2GUCY@201174|Actinobacteria	201174|Actinobacteria	L	CRISPR associated protein Cas6	-	-	-	-	-	-	-	-	-	-	-	-	Cas_Cas6
HKD2_k127_2583910_5	1120936.KB907215_gene3963	1.55e-95	332.0	2B891@1|root,321HN@2|Bacteria,2H5JP@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2583910_2	1120936.KB907215_gene3964	5.773e-143	473.0	COG1857@1|root,COG1857@2|Bacteria,2GR3E@201174|Actinobacteria	201174|Actinobacteria	L	CRISPR-associated autoregulator DevR family	-	-	-	ko:K19075	-	-	-	-	ko00000,ko02048	-	-	-	DevR
HKD2_k127_2583910_8	1120936.KB907215_gene3965	1.273e-69	245.0	COG1688@1|root,COG1688@2|Bacteria	2|Bacteria	L	defense response to virus	cas5t	-	-	ko:K07012,ko:K19090	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	Cas_Cas5d
HKD2_k127_2583910_0	1449355.JQNR01000005_gene4409	5.653e-236	767.0	COG1203@1|root,COG1688@1|root,COG1203@2|Bacteria,COG1688@2|Bacteria,2GMM0@201174|Actinobacteria	201174|Actinobacteria	L	CRISPR-associated helicase Cas3	-	-	-	-	-	-	-	-	-	-	-	-	DEAD
HKD2_k127_2583910_9	1449355.JQNR01000005_gene4408	6.752e-68	234.0	COG1468@1|root,COG1468@2|Bacteria,2IGQG@201174|Actinobacteria	201174|Actinobacteria	L	Domain of unknown function DUF83	-	-	3.1.12.1	ko:K07464	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	Cas_Cas4
HKD2_k127_2583910_26	1157638.KB892209_gene1109	0.0001846	49.0	COG1518@1|root,COG1518@2|Bacteria,2I8M0@201174|Actinobacteria	201174|Actinobacteria	L	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette	cas1	-	-	ko:K15342	-	-	-	-	ko00000,ko02048,ko03400	-	-	-	Cas_Cas1
HKD2_k127_2583910_13	1449355.JQNR01000005_gene4407	1.864e-31	127.0	COG1518@1|root,COG1518@2|Bacteria,2I8M0@201174|Actinobacteria	201174|Actinobacteria	L	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette	cas1	-	-	ko:K15342	-	-	-	-	ko00000,ko02048,ko03400	-	-	-	Cas_Cas1
HKD2_k127_2583910_6	1449355.JQNR01000005_gene4407	1.048e-90	301.0	COG1518@1|root,COG1518@2|Bacteria,2I8M0@201174|Actinobacteria	201174|Actinobacteria	L	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette	cas1	-	-	ko:K15342	-	-	-	-	ko00000,ko02048,ko03400	-	-	-	Cas_Cas1
HKD2_k127_2583910_16	1449355.JQNR01000005_gene4406	1.984e-30	121.0	COG1343@1|root,COG1343@2|Bacteria,2IT0N@201174|Actinobacteria	201174|Actinobacteria	L	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette	cas2	-	-	ko:K09951	-	-	-	-	ko00000,ko02048	-	-	-	CRISPR_Cas2
HKD2_k127_2588416_3	1123023.JIAI01000001_gene6542	7.061e-42	159.0	COG3764@1|root,COG3764@2|Bacteria,2IR30@201174|Actinobacteria	201174|Actinobacteria	M	peptidase C60 sortase A and B	-	-	-	-	-	-	-	-	-	-	-	-	Sortase
HKD2_k127_2588416_0	326424.FRAAL0997	5.993e-218	683.0	COG0001@1|root,COG0001@2|Bacteria,2GJSH@201174|Actinobacteria,4ERKP@85013|Frankiales	201174|Actinobacteria	H	PFAM Aminotransferase class-III	hemL	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
HKD2_k127_2588416_1	656024.FsymDg_4038	5.335e-84	304.0	COG0406@1|root,COG0406@2|Bacteria,2GMXF@201174|Actinobacteria,4ESMJ@85013|Frankiales	201174|Actinobacteria	G	phosphoglycerate mutase	-	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	His_Phos_1
HKD2_k127_2588416_2	106370.Francci3_0510	3.679e-67	234.0	COG0526@1|root,COG0526@2|Bacteria,2GP7J@201174|Actinobacteria,4ET99@85013|Frankiales	201174|Actinobacteria	CO	Alkyl hydroperoxide reductase Thiol specific antioxidant	-	-	-	ko:K02199	-	-	-	-	ko00000,ko03110	-	-	-	AhpC-TSA,Redoxin
HKD2_k127_2588416_4	1211815.CBYP010000047_gene1625	1.765e-27	124.0	COG0785@1|root,COG0785@2|Bacteria,2GJW3@201174|Actinobacteria,4ESK1@85013|Frankiales	201174|Actinobacteria	O	cytochrome c biogenesis protein	ccdA	-	-	ko:K06196	-	-	-	-	ko00000,ko02000	5.A.1.2	-	-	DsbD
HKD2_k127_2599316_2	656024.FsymDg_3116	1.89e-117	384.0	COG0769@1|root,COG0769@2|Bacteria,2GIS2@201174|Actinobacteria,4ES9W@85013|Frankiales	201174|Actinobacteria	M	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan	murE	GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008765,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	6.3.2.13	ko:K01928	ko00300,ko00550,map00300,map00550	-	R02788	RC00064,RC00090	ko00000,ko00001,ko01000,ko01011	-	-	iNJ661.Rv2158c	Mur_ligase,Mur_ligase_C,Mur_ligase_M
HKD2_k127_2599316_1	365528.KB891102_gene4421	2.588e-158	512.0	COG0770@1|root,COG0770@2|Bacteria,2GK0Y@201174|Actinobacteria,4EREQ@85013|Frankiales	201174|Actinobacteria	M	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein	murF	-	6.3.2.10	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	-	R04573,R04617	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
HKD2_k127_2599316_0	656024.FsymDg_3114	1.414e-189	614.0	COG0472@1|root,COG0472@2|Bacteria,2GNEH@201174|Actinobacteria,4ERUH@85013|Frankiales	201174|Actinobacteria	M	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan	mraY	GO:0008150,GO:0040007	2.7.8.13	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	-	R05629,R05630	RC00002,RC02753	ko00000,ko00001,ko01000,ko01011	9.B.146	-	-	Glycos_transf_4,MraY_sig1
HKD2_k127_2599316_3	106370.Francci3_1413	6.666e-29	131.0	COG0771@1|root,COG0771@2|Bacteria,2GJZA@201174|Actinobacteria,4ERI0@85013|Frankiales	201174|Actinobacteria	M	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)	murD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464	6.3.2.9	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R02783	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	iNJ661.Rv2155c	AlaDh_PNT_C,Mur_ligase_C,Mur_ligase_M
HKD2_k127_2601181_1	106370.Francci3_2058	5.682e-06	48.0	COG5433@1|root,COG5433@2|Bacteria,2HYBN@201174|Actinobacteria,4EWGM@85013|Frankiales	201174|Actinobacteria	L	required for the transposition of insertion element IS2404	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_assoc
HKD2_k127_2601181_0	316274.Haur_1804	5.334e-30	132.0	COG1535@1|root,COG3433@1|root,COG1535@2|Bacteria,COG3433@2|Bacteria	2|Bacteria	Q	isochorismatase activity	entB	GO:0000287,GO:0003674,GO:0003824,GO:0004463,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008908,GO:0009058,GO:0009237,GO:0009238,GO:0009239,GO:0009712,GO:0009713,GO:0009987,GO:0016020,GO:0016740,GO:0016765,GO:0016787,GO:0016801,GO:0016803,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0018958,GO:0019184,GO:0019290,GO:0019438,GO:0019540,GO:0019748,GO:0019842,GO:0031177,GO:0033218,GO:0034641,GO:0036094,GO:0042802,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044550,GO:0046189,GO:0046483,GO:0046872,GO:0047527,GO:0048037,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:0072341,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	3.3.2.1,3.3.2.15,6.3.2.14	ko:K01252,ko:K20261	ko00405,ko01053,ko01110,ko01130,ko02024,map00405,map01053,map01110,map01130,map02024	M00835	R03037,R07644,R11463	RC00162,RC00350,RC02148,RC03046	ko00000,ko00001,ko00002,ko01000,ko01008	-	-	iSFV_1184.SFV_0543	Isochorismatase,PP-binding
HKD2_k127_2607929_5	222534.KB893740_gene1532	5.897e-15	76.0	COG1961@1|root,COG1961@2|Bacteria,2I8HV@201174|Actinobacteria	201174|Actinobacteria	L	COG1961 Site-specific recombinases, DNA invertase Pin homologs	-	-	-	ko:K06400	-	-	-	-	ko00000	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
HKD2_k127_2607929_4	298653.Franean1_5788	1.227e-69	240.0	COG2514@1|root,COG2514@2|Bacteria,2GUZK@201174|Actinobacteria	201174|Actinobacteria	S	PFAM Glyoxalase bleomycin resistance protein dioxygenase	-	-	1.13.11.2	ko:K07104	ko00361,ko00362,ko00622,ko00643,ko01100,ko01120,ko01220,map00361,map00362,map00622,map00643,map01100,map01120,map01220	M00569	R00816,R04089,R05295,R05404,R05406,R07795	RC00387,RC00643,RC01075,RC01364,RC01914	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyoxalase
HKD2_k127_2607929_1	365528.KB891211_gene2382	1.004e-125	430.0	COG2265@1|root,COG2265@2|Bacteria,2GK97@201174|Actinobacteria,4ESJB@85013|Frankiales	201174|Actinobacteria	J	COG0500 SAM-dependent methyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_15,Methyltransf_25
HKD2_k127_2607929_0	105425.BBPL01000003_gene6783	3.619e-130	422.0	COG2159@1|root,COG2159@2|Bacteria,2GMQY@201174|Actinobacteria,2NFUG@228398|Streptacidiphilus	201174|Actinobacteria	S	Amidohydrolase	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
HKD2_k127_2607929_3	365528.KB891211_gene2383	1.036e-75	256.0	COG0691@1|root,COG0691@2|Bacteria,2GJX1@201174|Actinobacteria,4ESH9@85013|Frankiales	201174|Actinobacteria	O	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene	smpB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K03664	-	-	-	-	ko00000	-	-	-	SmpB
HKD2_k127_2607929_2	1120936.KB907208_gene726	5.755e-92	317.0	COG0793@1|root,COG0793@2|Bacteria,2GKRP@201174|Actinobacteria,4EIH6@85012|Streptosporangiales	201174|Actinobacteria	M	tail specific protease	-	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_S41
HKD2_k127_2625111_8	1150864.MILUP08_46439	1.817e-16	79.0	COG4627@1|root,COG4627@2|Bacteria,2IHF2@201174|Actinobacteria,4DGAI@85008|Micromonosporales	201174|Actinobacteria	S	Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	BON,Methyltransf_11
HKD2_k127_2625111_6	1122611.KB903940_gene1765	2.77e-37	158.0	COG5592@1|root,COG5592@2|Bacteria,2HF5Y@201174|Actinobacteria,4EJFU@85012|Streptosporangiales	201174|Actinobacteria	S	Hemerythrin HHE cation binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
HKD2_k127_2625111_3	526225.Gobs_3687	5.691e-68	239.0	COG2267@1|root,COG2267@2|Bacteria	2|Bacteria	I	carboxylic ester hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4,Rrf2
HKD2_k127_2625111_5	479432.Sros_3596	9.334e-47	176.0	2CDI4@1|root,32YR4@2|Bacteria,2IINI@201174|Actinobacteria,4EPP7@85012|Streptosporangiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2625111_1	1146883.BLASA_1740	9.555e-141	457.0	COG0025@1|root,COG0025@2|Bacteria,2I37Q@201174|Actinobacteria	201174|Actinobacteria	P	Sodium hydrogen exchanger	nhaP	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
HKD2_k127_2625111_2	1906.SFRA_05605	2.656e-79	275.0	COG0697@1|root,COG0697@2|Bacteria,2GRXH@201174|Actinobacteria	201174|Actinobacteria	EG	Permeases of the drug metabolite transporter (DMT) superfamily	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2625111_0	106370.Francci3_2496	1.229e-234	744.0	COG1032@1|root,COG1032@2|Bacteria,2HGPR@201174|Actinobacteria	201174|Actinobacteria	C	Radical SAM	-	-	-	ko:K18563	ko00332,ko01130,map00332,map01130	-	R10737	RC03265	ko00000,ko00001,ko01000	-	-	-	B12-binding,Radical_SAM
HKD2_k127_2625111_4	479433.Caci_8385	1.113e-60	233.0	COG4129@1|root,COG4129@2|Bacteria,2GIR7@201174|Actinobacteria	201174|Actinobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	ArAE_1
HKD2_k127_2625111_7	1265310.CCBD010000070_gene35	6.066e-18	86.0	COG4221@1|root,COG4221@2|Bacteria,2I2YS@201174|Actinobacteria,2367K@1762|Mycobacteriaceae	201174|Actinobacteria	S	Short chain dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HKD2_k127_2648108_2	1146883.BLASA_4209	2.079e-149	477.0	COG0039@1|root,COG0039@2|Bacteria,2GN5S@201174|Actinobacteria,4ESBM@85013|Frankiales	201174|Actinobacteria	C	Catalyzes the reversible oxidation of malate to oxaloacetate	mdh	-	1.1.1.27,1.1.1.37	ko:K00016,ko:K00024	ko00010,ko00020,ko00270,ko00620,ko00630,ko00640,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04922,map00010,map00020,map00270,map00620,map00630,map00640,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200,map04922	M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740	R00342,R00703,R01000,R03104,R07136	RC00031,RC00044	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Ldh_1_C,Ldh_1_N
HKD2_k127_2648108_1	1283283.ATXA01000007_gene3850	1.609e-156	505.0	COG1253@1|root,COG1253@2|Bacteria,2GKN5@201174|Actinobacteria,4ERVV@85013|Frankiales	201174|Actinobacteria	S	CBS domain containing protein	-	-	-	ko:K03699	-	-	-	-	ko00000,ko02042	-	-	-	CBS,CorC_HlyC,DUF21
HKD2_k127_2648108_0	656024.FsymDg_3884	2.412e-158	508.0	COG0644@1|root,COG0644@2|Bacteria,2GMH9@201174|Actinobacteria,4EUG7@85013|Frankiales	201174|Actinobacteria	C	geranylgeranyl reductase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3
HKD2_k127_2648108_3	675635.Psed_5302	6.722e-144	474.0	COG0180@1|root,COG0180@2|Bacteria,2GJ9A@201174|Actinobacteria,4E1GX@85010|Pseudonocardiales	201174|Actinobacteria	J	Tryptophanyl-tRNA synthetase	trpS	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
HKD2_k127_2648108_6	298653.Franean1_5967	3.893e-69	241.0	COG1514@1|root,COG1514@2|Bacteria,2GRF0@201174|Actinobacteria,4ESTP@85013|Frankiales	201174|Actinobacteria	J	2'-5' RNA ligase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	2_5_RNA_ligase2
HKD2_k127_2648108_4	106370.Francci3_0663	1.548e-115	383.0	COG1295@1|root,COG1295@2|Bacteria,2GN79@201174|Actinobacteria,4ET18@85013|Frankiales	201174|Actinobacteria	S	PFAM ribonuclease	yhjD	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Virul_fac_BrkB
HKD2_k127_2648108_5	298654.FraEuI1c_6146	6.275e-72	266.0	COG1686@1|root,COG1686@2|Bacteria,2GK3M@201174|Actinobacteria,4ESJ8@85013|Frankiales	201174|Actinobacteria	M	Belongs to the peptidase S11 family	dac	-	3.4.16.4	ko:K07258	ko00550,ko01100,map00550,map01100	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	Peptidase_S11
HKD2_k127_2648108_7	196162.Noca_2898	2.802e-45	172.0	2DSM3@1|root,33GM1@2|Bacteria	2|Bacteria	S	Polyketide cyclase / dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
HKD2_k127_2648108_15	1133849.O3I_018280	0.0005907	48.0	2AY9E@1|root,31QBR@2|Bacteria,2HSF2@201174|Actinobacteria,4G3ZK@85025|Nocardiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2648108_9	106370.Francci3_0670	8.425e-27	118.0	COG1598@1|root,COG1598@2|Bacteria,2GSPM@201174|Actinobacteria	201174|Actinobacteria	S	PFAM Uncharacterised protein family UPF0150	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2648108_13	222534.KB893683_gene1230	1.833e-06	53.0	COG1724@1|root,COG1724@2|Bacteria,2GYGF@201174|Actinobacteria	201174|Actinobacteria	N	HicA toxin of bacterial toxin-antitoxin,	-	-	-	-	-	-	-	-	-	-	-	-	HicA_toxin
HKD2_k127_2648108_10	365528.KB891159_gene5330	3.565e-08	57.0	COG1724@1|root,COG1724@2|Bacteria,2GYGF@201174|Actinobacteria	201174|Actinobacteria	N	HicA toxin of bacterial toxin-antitoxin,	-	-	-	-	-	-	-	-	-	-	-	-	HicA_toxin
HKD2_k127_2648108_14	330084.JNYZ01000013_gene5856	0.0002665	52.0	COG2929@1|root,COG2929@2|Bacteria	2|Bacteria	S	Ribonuclease toxin, BrnT, of type II toxin-antitoxin system	-	-	-	ko:K09803	-	-	-	-	ko00000	-	-	-	BrnT_toxin
HKD2_k127_2648108_12	710111.FraQA3DRAFT_3776	1.076e-07	59.0	2E5D5@1|root,33055@2|Bacteria,2IR7Y@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2648108_8	1206725.BAFU01000233_gene5589	1.284e-29	127.0	COG0457@1|root,COG0457@2|Bacteria,2GJSG@201174|Actinobacteria,4G3HA@85025|Nocardiaceae	201174|Actinobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	HTH_31
HKD2_k127_2651763_1	469371.Tbis_2253	7.289e-253	799.0	COG1523@1|root,COG1523@2|Bacteria,2GJ00@201174|Actinobacteria,4DZ6I@85010|Pseudonocardiales	201174|Actinobacteria	G	Belongs to the glycosyl hydrolase 13 family	glgX	-	3.2.1.68	ko:K01214	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
HKD2_k127_2651763_0	656024.FsymDg_3799	0.0	1405.0	COG0058@1|root,COG0058@2|Bacteria,2GIVZ@201174|Actinobacteria,4ES7U@85013|Frankiales	201174|Actinobacteria	G	PFAM glycosyl transferase, family 35	glgP	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	DUF3417,Phosphorylase
HKD2_k127_2651763_5	869210.Marky_1813	1.432e-92	316.0	COG2905@1|root,COG2905@2|Bacteria,1WIBT@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	T	signal-transduction protein containing cAMP-binding and CBS domains	-	-	-	ko:K07182	-	-	-	-	ko00000	-	-	-	CBS,DUF294,DUF294_C,cNMP_binding
HKD2_k127_2651763_10	1504672.669784320	1.942e-24	121.0	COG2176@1|root,COG2176@2|Bacteria,1QUVW@1224|Proteobacteria,2VHZ3@28216|Betaproteobacteria,4AD1W@80864|Comamonadaceae	28216|Betaproteobacteria	L	Exonuclease	-	-	2.7.7.7	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	RNase_T
HKD2_k127_2651763_8	85643.Tmz1t_2648	3.705e-74	258.0	COG2176@1|root,COG2176@2|Bacteria,1QUVW@1224|Proteobacteria,2VHZ3@28216|Betaproteobacteria,2KUQR@206389|Rhodocyclales	206389|Rhodocyclales	L	DNA polymerase III	-	-	2.7.7.7	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	RNase_T
HKD2_k127_2651763_2	656024.FsymDg_3366	3.535e-220	691.0	COG1672@1|root,COG1672@2|Bacteria,2GMAZ@201174|Actinobacteria,4EUDR@85013|Frankiales	201174|Actinobacteria	S	Pfam:Arch_ATPase	-	-	-	ko:K06921	-	-	-	-	ko00000	-	-	-	AAA_16,DUF234
HKD2_k127_2651763_3	1223523.H340_22726	6.288e-203	646.0	COG4147@1|root,COG4147@2|Bacteria,2GJ56@201174|Actinobacteria	201174|Actinobacteria	S	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	-	-	-	ko:K14393	-	-	-	-	ko00000,ko02000	2.A.21.7	-	-	SSF
HKD2_k127_2651763_12	208444.JNYY01000010_gene2848	5.832e-21	100.0	COG3162@1|root,COG3162@2|Bacteria,2IQ5D@201174|Actinobacteria,4E4IN@85010|Pseudonocardiales	201174|Actinobacteria	S	Protein of unknown function, DUF485	-	-	-	-	-	-	-	-	-	-	-	-	DUF485
HKD2_k127_2651763_6	1089544.KB912942_gene4668	2.957e-89	308.0	COG3275@1|root,COG3275@2|Bacteria,2GJD4@201174|Actinobacteria,4EDVB@85010|Pseudonocardiales	201174|Actinobacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K02478	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	HATPase_c,His_kinase
HKD2_k127_2651763_7	882082.SaccyDRAFT_1430	1.074e-75	276.0	COG3279@1|root,COG3279@2|Bacteria,2GKK5@201174|Actinobacteria,4E0I3@85010|Pseudonocardiales	201174|Actinobacteria	KT	Response regulator of the LytR AlgR family	-	-	-	-	-	-	-	-	-	-	-	-	LytTR,Response_reg
HKD2_k127_2651763_13	909613.UO65_1772	2.073e-14	79.0	2DMI1@1|root,32RNK@2|Bacteria,2GTFQ@201174|Actinobacteria,4E61I@85010|Pseudonocardiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2651763_4	909613.UO65_1771	3.271e-168	554.0	COG4147@1|root,COG4147@2|Bacteria,2GM3H@201174|Actinobacteria,4E19G@85010|Pseudonocardiales	201174|Actinobacteria	S	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	-	-	-	-	-	-	-	-	-	-	-	-	SSF
HKD2_k127_2651763_11	1146883.BLASA_2737	5.982e-24	102.0	2BIV6@1|root,32D37@2|Bacteria,2GS65@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2651763_9	1146883.BLASA_2736	2.782e-54	197.0	COG1487@1|root,COG1487@2|Bacteria,2IJUM@201174|Actinobacteria	201174|Actinobacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	vapC	GO:0008150,GO:0040008,GO:0045926,GO:0048519,GO:0050789,GO:0065007	-	-	-	-	-	-	-	-	-	-	PIN
HKD2_k127_2655040_2	1463853.JOHW01000008_gene1114	2.856e-09	58.0	COG2310@1|root,COG2340@1|root,COG2310@2|Bacteria,COG2340@2|Bacteria,2GNN0@201174|Actinobacteria	201174|Actinobacteria	T	Cysteine-rich secretory protein family	-	-	-	-	-	-	-	-	-	-	-	-	CAP,TerD
HKD2_k127_2655040_1	222534.KB893711_gene5050	7.448e-13	77.0	COG0582@1|root,COG0582@2|Bacteria,2GMMI@201174|Actinobacteria,4ESP4@85013|Frankiales	201174|Actinobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_3,Phage_integrase
HKD2_k127_2655040_0	298653.Franean1_0694	1.968e-41	158.0	293R4@1|root,2ZR6S@2|Bacteria,2GXGP@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2663302_1	298654.FraEuI1c_0217	0.0	1063.0	COG0443@1|root,COG0443@2|Bacteria,2GJTY@201174|Actinobacteria,4ERTY@85013|Frankiales	201174|Actinobacteria	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
HKD2_k127_2663302_4	710111.FraQA3DRAFT_5092	7.731e-72	255.0	COG0576@1|root,COG0576@2|Bacteria,2GP4F@201174|Actinobacteria,4ESWP@85013|Frankiales	201174|Actinobacteria	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	grpE	GO:0000166,GO:0000774,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0017076,GO:0030234,GO:0030312,GO:0030554,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0036094,GO:0040007,GO:0042594,GO:0044464,GO:0050790,GO:0050896,GO:0051082,GO:0051716,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0071496,GO:0071944,GO:0097159,GO:0098772,GO:1901265,GO:1901363	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
HKD2_k127_2663302_2	298653.Franean1_0231	1.449e-168	555.0	COG0484@1|root,COG0484@2|Bacteria,2GJKK@201174|Actinobacteria,4ERZT@85013|Frankiales	201174|Actinobacteria	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0010468,GO:0016020,GO:0019222,GO:0030312,GO:0040007,GO:0043388,GO:0044093,GO:0044464,GO:0050789,GO:0051098,GO:0051099,GO:0051101,GO:0060255,GO:0065007,GO:0065009,GO:0071944,GO:2000677,GO:2000679	-	ko:K03686,ko:K05516	-	-	-	-	ko00000,ko03029,ko03036,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
HKD2_k127_2663302_5	298653.Franean1_0230	4.773e-55	211.0	COG0789@1|root,COG0789@2|Bacteria,2IQJ4@201174|Actinobacteria,4ET08@85013|Frankiales	201174|Actinobacteria	K	transcriptional regulator, MerR	hspR	GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141	-	ko:K13640	-	-	-	-	ko00000,ko03000	-	-	-	MerR_1
HKD2_k127_2663302_0	656024.FsymDg_0617	0.0	1388.0	COG0542@1|root,COG0542@2|Bacteria,2GJ73@201174|Actinobacteria,4ERET@85013|Frankiales	201174|Actinobacteria	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpB	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	-	ko:K03695,ko:K03696	ko01100,ko04213,map01100,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
HKD2_k127_2663302_3	656024.FsymDg_0615	1.102e-131	467.0	COG2409@1|root,COG2409@2|Bacteria,2GIRQ@201174|Actinobacteria,4ERP1@85013|Frankiales	201174|Actinobacteria	S	PFAM MMPL domain protein	-	-	-	ko:K06994	-	-	-	-	ko00000	-	-	-	MMPL
HKD2_k127_2663302_7	326424.FRAAL6646	1.756e-41	171.0	COG2409@1|root,COG2409@2|Bacteria,2GIRQ@201174|Actinobacteria,4ERP1@85013|Frankiales	201174|Actinobacteria	S	PFAM MMPL domain protein	-	-	-	ko:K06994	-	-	-	-	ko00000	-	-	-	MMPL
HKD2_k127_2663302_8	55952.BU52_26035	1.097e-29	121.0	COG2409@1|root,COG2409@2|Bacteria,2GIRQ@201174|Actinobacteria	201174|Actinobacteria	T	PFAM MMPL domain protein	-	-	-	ko:K06994	-	-	-	-	ko00000	-	-	-	MMPL
HKD2_k127_2663302_9	298654.FraEuI1c_0208	1.175e-27	123.0	2ECD3@1|root,336BC@2|Bacteria,2I56Z@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2663302_6	326424.FRAAL6649	1.724e-46	183.0	2ECD3@1|root,336BC@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2673217_4	298653.Franean1_3403	1.856e-94	327.0	COG1740@1|root,COG1740@2|Bacteria,2GKF2@201174|Actinobacteria	201174|Actinobacteria	C	Small subunit	hoxK	-	1.12.99.6	ko:K06282	ko00633,ko01120,map00633,map01120	-	R08034	RC00250	ko00000,ko00001,ko01000	-	-	-	NiFe_hyd_SSU_C,Oxidored_q6
HKD2_k127_2673217_8	656024.FsymDg_4085	7.475e-56	200.0	COG2044@1|root,COG2044@2|Bacteria,2IHT6@201174|Actinobacteria	201174|Actinobacteria	S	DsrE/DsrF-like family	-	-	-	-	-	-	-	-	-	-	-	-	DrsE
HKD2_k127_2673217_5	710111.FraQA3DRAFT_4005	7.114e-77	261.0	COG4044@1|root,COG4044@2|Bacteria,2GKGF@201174|Actinobacteria,4ET7U@85013|Frankiales	201174|Actinobacteria	S	May play a role in the intracellular transport of hydrophobic ligands	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DUF1794
HKD2_k127_2673217_7	298654.FraEuI1c_6327	1.607e-71	263.0	COG0115@1|root,COG0115@2|Bacteria,2GN5Z@201174|Actinobacteria	201174|Actinobacteria	EH	Branched-chain amino acid aminotransferase 4-amino-4-deoxychorismate lyase	pabC	-	4.1.3.38	ko:K02619	ko00790,map00790	-	R05553	RC01843,RC02148	ko00000,ko00001,ko01000	-	-	-	Aminotran_4
HKD2_k127_2673217_10	656024.FsymDg_4071	4.242e-44	181.0	COG0735@1|root,COG0735@2|Bacteria,2IFHB@201174|Actinobacteria,4ESU5@85013|Frankiales	201174|Actinobacteria	P	Belongs to the Fur family	-	-	-	ko:K03711,ko:K09825	-	-	-	-	ko00000,ko03000	-	-	-	FUR
HKD2_k127_2673217_1	710111.FraQA3DRAFT_3989	3.39e-130	432.0	COG0354@1|root,COG0354@2|Bacteria,2GKP0@201174|Actinobacteria,4ERU1@85013|Frankiales	201174|Actinobacteria	S	Belongs to the GcvT family	ygfZ	-	-	ko:K06980	-	-	-	-	ko00000,ko03016	-	-	-	GCV_T,GCV_T_C
HKD2_k127_2673217_2	477641.MODMU_5030	6.189e-123	400.0	COG3246@1|root,COG3246@2|Bacteria,2I9EQ@201174|Actinobacteria,4EUAD@85013|Frankiales	201174|Actinobacteria	S	beta-keto acid cleavage enzyme	-	-	-	-	-	-	-	-	-	-	-	-	BKACE
HKD2_k127_2673217_12	1048339.KB913029_gene73	1.541e-24	108.0	COG2154@1|root,COG2154@2|Bacteria,2IKXR@201174|Actinobacteria,4ET9E@85013|Frankiales	201174|Actinobacteria	H	PFAM transcriptional coactivator pterin dehydratase	phhB	-	4.2.1.96	ko:K01724	ko00790,map00790	-	R04734	RC01208	ko00000,ko00001,ko01000,ko04147	-	-	-	Pterin_4a
HKD2_k127_2673217_3	105420.BBPO01000100_gene6296	2.076e-122	398.0	COG2326@1|root,COG2326@2|Bacteria,2GKRN@201174|Actinobacteria,2NGIJ@228398|Streptacidiphilus	201174|Actinobacteria	S	Polyphosphate kinase 2 (PPK2)	ppk2	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0005488,GO:0005525,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006140,GO:0006163,GO:0006164,GO:0006183,GO:0006464,GO:0006468,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008976,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009889,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0017076,GO:0018130,GO:0019001,GO:0019219,GO:0019220,GO:0019222,GO:0019438,GO:0019538,GO:0019637,GO:0019693,GO:0030808,GO:0031323,GO:0031326,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034404,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0036211,GO:0040007,GO:0042278,GO:0042451,GO:0042455,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044121,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044283,GO:0044403,GO:0044419,GO:0044464,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0046777,GO:0050789,GO:0050794,GO:0051171,GO:0051174,GO:0051704,GO:0055086,GO:0062012,GO:0065007,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0080090,GO:0090407,GO:0097159,GO:0097367,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.7.4.1	ko:K22468	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PPK2
HKD2_k127_2673217_0	298654.FraEuI1c_6335	1.785e-135	443.0	COG1196@1|root,COG1196@2|Bacteria,2GJBD@201174|Actinobacteria,4ES6S@85013|Frankiales	201174|Actinobacteria	D	Domain of Unknown Function (DUF349)	-	-	-	-	-	-	-	-	-	-	-	-	DUF349
HKD2_k127_2673217_13	1110697.NCAST_20_01200	1.179e-22	105.0	COG2337@1|root,COG2337@2|Bacteria,2IMUI@201174|Actinobacteria	201174|Actinobacteria	T	PemK-like, MazF-like toxin of type II toxin-antitoxin system	-	-	-	ko:K07171	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PemK_toxin
HKD2_k127_2673217_14	526225.Gobs_3713	0.0003772	49.0	299PR@1|root,2ZWS2@2|Bacteria,2HCZT@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2673217_9	298655.KI912266_gene458	5.739e-48	180.0	COG1396@1|root,COG1396@2|Bacteria,2IKVI@201174|Actinobacteria,4ET27@85013|Frankiales	201174|Actinobacteria	K	transcriptional regulator, XRE family	-	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	HTH_3,HTH_31
HKD2_k127_2673217_6	326424.FRAAL0954	6.521e-74	258.0	COG0667@1|root,COG0667@2|Bacteria,2GMNA@201174|Actinobacteria,4ES2N@85013|Frankiales	201174|Actinobacteria	C	PFAM aldo keto reductase	-	-	1.1.1.91	ko:K05882	-	-	-	-	ko00000,ko01000	-	-	-	Aldo_ket_red
HKD2_k127_2680683_0	710111.FraQA3DRAFT_3676	1.866e-254	804.0	COG0744@1|root,COG0744@2|Bacteria,2GK21@201174|Actinobacteria,4ERGQ@85013|Frankiales	201174|Actinobacteria	M	PFAM glycosyl transferase, family 51	pon1	-	-	-	-	-	-	-	-	-	-	-	PASTA,Transgly,Transpeptidase
HKD2_k127_2689324_2	1147.D082_28720	1.632e-163	526.0	COG0076@1|root,COG0076@2|Bacteria,1G47D@1117|Cyanobacteria,1H682@1142|Synechocystis	1117|Cyanobacteria	E	Pyridoxal-dependent decarboxylase conserved domain	gad	-	4.1.1.15	ko:K01580	ko00250,ko00410,ko00430,ko00650,ko01100,ko01110,ko01120,ko02024,ko04727,ko04940,map00250,map00410,map00430,map00650,map01100,map01110,map01120,map02024,map04727,map04940	M00027	R00261,R00489,R01682,R02466	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Pyridoxal_deC
HKD2_k127_2689324_12	1003195.SCAT_1267	1.641e-26	117.0	2ES7R@1|root,33JSG@2|Bacteria,2IQ6C@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2689324_4	656024.FsymDg_3172	1.469e-142	485.0	COG3688@1|root,COG3688@2|Bacteria,2GR19@201174|Actinobacteria,4EVDT@85013|Frankiales	201174|Actinobacteria	S	YacP-like NYN domain	-	-	-	-	-	-	-	-	-	-	-	-	NYN_YacP
HKD2_k127_2689324_13	365528.KB891203_gene3432	4.188e-19	89.0	2EGHN@1|root,33A9R@2|Bacteria,2GSZ1@201174|Actinobacteria,4ETGC@85013|Frankiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2689324_1	656024.FsymDg_3159	1.859e-180	572.0	COG0438@1|root,COG0438@2|Bacteria,2GM6D@201174|Actinobacteria,4ERSX@85013|Frankiales	201174|Actinobacteria	M	PFAM Glycosyl transferase, group 1	pimB	GO:0000009,GO:0000030,GO:0003674,GO:0003824,GO:0004376,GO:0005575,GO:0005623,GO:0005886,GO:0006629,GO:0006643,GO:0006664,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016758,GO:0033164,GO:0040007,GO:0043750,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0046467,GO:0070085,GO:0071704,GO:0071944,GO:0097502,GO:1901135,GO:1901137,GO:1901576,GO:1903509	2.4.1.346	ko:K13668	-	-	R11703,R11704	-	ko00000,ko01000,ko01003	-	GT4	-	Glyco_transf_4,Glycos_transf_1
HKD2_k127_2689324_9	710686.Mycsm_00248	8.648e-64	227.0	COG4291@1|root,COG4291@2|Bacteria,2IIVD@201174|Actinobacteria,23763@1762|Mycobacteriaceae	201174|Actinobacteria	S	Protein of unknown function (DUF1345)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1345
HKD2_k127_2689324_0	1146883.BLASA_1235	6.353e-239	753.0	COG1022@1|root,COG1022@2|Bacteria,2GIXQ@201174|Actinobacteria,4ERR6@85013|Frankiales	201174|Actinobacteria	I	PFAM AMP-dependent synthetase and ligase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
HKD2_k127_2689324_10	656024.FsymDg_3158	8.277e-52	187.0	COG2867@1|root,COG2867@2|Bacteria,2IIBS@201174|Actinobacteria	201174|Actinobacteria	I	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2689324_6	710111.FraQA3DRAFT_6427	3.4e-132	426.0	COG2129@1|root,COG2129@2|Bacteria,2GMTQ@201174|Actinobacteria,4ESW9@85013|Frankiales	201174|Actinobacteria	S	Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos,Metallophos_2
HKD2_k127_2689324_11	710111.FraQA3DRAFT_6428	6.098e-45	171.0	COG2867@1|root,COG2867@2|Bacteria,2IFH4@201174|Actinobacteria,4ESWR@85013|Frankiales	201174|Actinobacteria	I	Cyclase dehydrase	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc,Polyketide_cyc2
HKD2_k127_2689324_3	1048339.KB913029_gene4599	8.801e-156	500.0	COG0003@1|root,COG0003@2|Bacteria,2GISZ@201174|Actinobacteria,4ERC7@85013|Frankiales	201174|Actinobacteria	P	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	arsA	-	3.6.3.16	ko:K01551	-	-	-	-	ko00000,ko01000,ko02000	3.A.19.1,3.A.21.1,3.A.4.1	-	-	ArsA_ATPase
HKD2_k127_2689324_5	710111.FraQA3DRAFT_6431	1.121e-140	452.0	COG1940@1|root,COG1940@2|Bacteria,2GJCQ@201174|Actinobacteria,4ERT7@85013|Frankiales	201174|Actinobacteria	GK	PFAM ROK family protein	glkA	GO:0003674,GO:0003824,GO:0004340,GO:0004396,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019200,GO:0019637,GO:0044237,GO:0044238,GO:0044262,GO:0044424,GO:0044464,GO:0046835,GO:0051156,GO:0071704,GO:1901135	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
HKD2_k127_2689324_8	529709.PYCH_07920	7.687e-83	286.0	COG0549@1|root,arCOG00863@2157|Archaea,2XTCB@28890|Euryarchaeota,243F1@183968|Thermococci	183968|Thermococci	E	Belongs to the carbamate kinase family	cpkA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006525,GO:0006527,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008804,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009987,GO:0016054,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019546,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	2.7.2.2	ko:K00926	ko00220,ko00230,ko00910,ko01100,ko01120,ko01200,map00220,map00230,map00910,map01100,map01120,map01200	-	R00150,R01395	RC00002,RC00043,RC02803,RC02804	ko00000,ko00001,ko01000	-	-	-	AA_kinase
HKD2_k127_2689324_15	1907.SGLAU_14830	2.054e-05	57.0	2DPEU@1|root,331SS@2|Bacteria,2GJT8@201174|Actinobacteria	201174|Actinobacteria	S	Golgi phosphoprotein 3 (GPP34)	-	-	-	-	-	-	-	-	-	-	-	-	GPP34
HKD2_k127_2689324_7	479435.Kfla_2826	9.184e-116	376.0	COG1915@1|root,COG1915@2|Bacteria,2GMEZ@201174|Actinobacteria,4DN71@85009|Propionibacteriales	201174|Actinobacteria	S	LOR/SDH bifunctional enzyme conserved region	-	-	-	-	-	-	-	-	-	-	-	-	Saccharop_dh_N
HKD2_k127_2697523_1	365528.KB891233_gene1754	1.084e-29	136.0	2DWSS@1|root,341Q8@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2697523_0	1136417.AZWE01000029_gene221	0.0	1224.0	COG0507@1|root,COG0507@2|Bacteria,2GJRK@201174|Actinobacteria,4DBBY@85008|Micromonosporales	201174|Actinobacteria	L	DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity	recD2	-	3.1.11.5	ko:K03581	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AAA_30,HHH_4,HHH_5,UvrD_C_2
HKD2_k127_2697523_2	547163.BN979_06558	4.885e-26	109.0	COG1028@1|root,COG1028@2|Bacteria,2GM7N@201174|Actinobacteria,237TI@1762|Mycobacteriaceae	201174|Actinobacteria	IQ	short chain dehydrogenase	-	-	1.3.1.33	ko:K00218	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R03845,R06286	RC01008	ko00000,ko00001,ko01000	-	-	-	adh_short
HKD2_k127_2700677_1	222534.KB893683_gene1201	2.622e-122	397.0	COG4770@1|root,COG4770@2|Bacteria,2GIZP@201174|Actinobacteria,4ES3A@85013|Frankiales	201174|Actinobacteria	I	Biotin carboxylase	bccA	-	6.3.4.14,6.4.1.2,6.4.1.3	ko:K11263	ko00061,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00741	R00742,R01859,R04385	RC00040,RC00097,RC00253,RC00367,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2
HKD2_k127_2700677_3	365528.KB891159_gene5360	1.901e-44	164.0	2EMID@1|root,33F70@2|Bacteria,2H135@201174|Actinobacteria	201174|Actinobacteria	S	Family of unknown function (DUF5313)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5313
HKD2_k127_2700677_0	326424.FRAAL1206	3.849e-211	673.0	COG1249@1|root,COG1249@2|Bacteria,2GMP7@201174|Actinobacteria,4ES8Q@85013|Frankiales	201174|Actinobacteria	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation	lpdA	GO:0000166,GO:0003674,GO:0003824,GO:0003955,GO:0005488,GO:0008150,GO:0008152,GO:0009405,GO:0016491,GO:0016651,GO:0016655,GO:0036094,GO:0043167,GO:0043168,GO:0044419,GO:0048037,GO:0050660,GO:0050661,GO:0050662,GO:0051704,GO:0055114,GO:0070401,GO:0097159,GO:1901265,GO:1901363	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
HKD2_k127_2700677_2	656024.FsymDg_1024	2.09e-72	246.0	COG3703@1|root,COG3703@2|Bacteria,2GJM9@201174|Actinobacteria,4EVDS@85013|Frankiales	201174|Actinobacteria	P	PFAM AIG2 family protein	-	-	-	-	-	-	-	-	-	-	-	-	AIG2_2
HKD2_k127_2729957_8	1206739.BAGJ01000250_gene4817	1.375e-10	61.0	COG3293@1|root,COG3293@2|Bacteria,2IIAY@201174|Actinobacteria,4G1V8@85025|Nocardiaceae	201174|Actinobacteria	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_2,DUF4096
HKD2_k127_2729957_5	1032480.MLP_53280	3.158e-55	204.0	2BXAD@1|root,33WG5@2|Bacteria,2IQGA@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2729957_3	1032480.MLP_53270	6.112e-69	244.0	2EE42@1|root,337YQ@2|Bacteria,2IA9N@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2729957_0	656024.FsymDg_0377	6.98e-150	488.0	COG0477@1|root,COG0477@2|Bacteria,2GKFJ@201174|Actinobacteria,4ERNW@85013|Frankiales	201174|Actinobacteria	EGP	Major facilitator superfamily	entS_1	-	-	-	-	-	-	-	-	-	-	-	MFS_3
HKD2_k127_2729957_1	656024.FsymDg_0247	3.763e-91	304.0	COG1573@1|root,COG1573@2|Bacteria,2GMPT@201174|Actinobacteria,4ESP2@85013|Frankiales	201174|Actinobacteria	L	Uracil-DNA glycosylase	dpo	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
HKD2_k127_2729957_4	103733.JNYO01000009_gene4706	1.775e-59	237.0	COG0668@1|root,COG0668@2|Bacteria,2HD92@201174|Actinobacteria,4E0HQ@85010|Pseudonocardiales	201174|Actinobacteria	M	Conserved TM helix	-	-	-	-	-	-	-	-	-	-	-	-	TM_helix
HKD2_k127_2729957_2	298653.Franean1_7236	4.135e-77	269.0	COG3509@1|root,COG3509@2|Bacteria	2|Bacteria	Q	xylan catabolic process	-	-	-	ko:K03932	-	-	-	-	ko00000	-	CE1	-	Esterase_phd
HKD2_k127_2775838_0	222534.KB893772_gene4630	6.74e-185	599.0	COG0815@1|root,COG1215@1|root,COG0815@2|Bacteria,COG1215@2|Bacteria,2GJ9F@201174|Actinobacteria,4ERH9@85013|Frankiales	201174|Actinobacteria	M	Transfers the fatty acyl group on membrane lipoproteins	lnt	-	-	ko:K03820	-	-	-	-	ko00000,ko01000	-	GT2	-	CN_hydrolase
HKD2_k127_2775838_1	326424.FRAAL3770	2.835e-113	377.0	COG1215@1|root,COG1215@2|Bacteria,2I2PK@201174|Actinobacteria	201174|Actinobacteria	M	PFAM Glycosyl transferase family 2	-	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2
HKD2_k127_2775838_4	110319.CF8_1993	1.039e-31	129.0	COG3030@1|root,COG3030@2|Bacteria,2IA8V@201174|Actinobacteria,4DR8M@85009|Propionibacteriales	201174|Actinobacteria	S	FxsA cytoplasmic membrane protein	-	-	-	ko:K07113	-	-	-	-	ko00000	-	-	-	FxsA
HKD2_k127_2775838_2	365528.KB891274_gene2712	7.659e-58	203.0	2CNY9@1|root,31DSU@2|Bacteria,2I80U@201174|Actinobacteria,4ET2J@85013|Frankiales	201174|Actinobacteria	K	Binds to RNA polymerase (RNAP), stimulating transcription from principal, but not alternative sigma factor promoters	rbpA	GO:0001098,GO:0001108,GO:0003674,GO:0005488,GO:0005515,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141	-	-	-	-	-	-	-	-	-	-	RbpA
HKD2_k127_2775838_5	298655.KI912266_gene3523	2.87e-17	89.0	COG0229@1|root,COG0229@2|Bacteria	2|Bacteria	O	peptide-methionine (R)-S-oxide reductase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2775838_3	710111.FraQA3DRAFT_1741	7.132e-39	147.0	COG0229@1|root,COG0229@2|Bacteria,2IHV0@201174|Actinobacteria,4ESRX@85013|Frankiales	201174|Actinobacteria	O	PFAM Methionine sulfoxide reductase B	msrB	-	1.8.4.12	ko:K07305	-	-	-	-	ko00000,ko01000	-	-	-	SelR
HKD2_k127_2777365_10	1120936.KB907216_gene3907	2.541e-34	132.0	COG0483@1|root,COG0483@2|Bacteria,2GKZZ@201174|Actinobacteria,4EG4P@85012|Streptosporangiales	201174|Actinobacteria	G	Inositol monophosphatase family	hisN	GO:0000105,GO:0003674,GO:0003824,GO:0004401,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042578,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	3.1.3.15,3.1.3.25	ko:K01092,ko:K05602	ko00340,ko00521,ko00562,ko01100,ko01110,ko01230,ko04070,map00340,map00521,map00562,map01100,map01110,map01230,map04070	M00026,M00131	R01185,R01186,R01187,R03013	RC00017,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
HKD2_k127_2777365_4	298655.KI912266_gene2036	7.997e-69	243.0	COG0584@1|root,COG0584@2|Bacteria	2|Bacteria	C	glycerophosphodiester phosphodiesterase activity	-	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD
HKD2_k127_2777365_7	266940.Krad_3698	6.635e-50	198.0	COG2208@1|root,COG3850@1|root,COG2208@2|Bacteria,COG3850@2|Bacteria,2IHH3@201174|Actinobacteria	201174|Actinobacteria	KT	stage II sporulation	-	-	-	-	-	-	-	-	-	-	-	-	SpoIIE
HKD2_k127_2777365_19	479432.Sros_5844	5.11e-06	58.0	COG4251@1|root,COG5278@1|root,COG4251@2|Bacteria,COG5278@2|Bacteria,2GK25@201174|Actinobacteria,4EGPI@85012|Streptosporangiales	201174|Actinobacteria	T	CHASE3 domain	-	-	-	-	-	-	-	-	-	-	-	-	CHASE3,HAMP,HATPase_c,HisKA
HKD2_k127_2777365_13	35754.JNYJ01000020_gene196	6.929e-17	90.0	COG4251@1|root,COG4251@2|Bacteria,2GK25@201174|Actinobacteria,4D8R1@85008|Micromonosporales	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE3,HAMP,HATPase_c,HisKA
HKD2_k127_2777365_0	290397.Adeh_0810	0.0	1068.0	COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,42M5I@68525|delta/epsilon subdivisions,2WK8Y@28221|Deltaproteobacteria,2YUG8@29|Myxococcales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG,FAD-oxidase_C,FAD_binding_4,Fer4_8
HKD2_k127_2777365_16	1289387.AUKW01000001_gene5354	2.41e-09	59.0	COG0520@1|root,COG0520@2|Bacteria,2GJA4@201174|Actinobacteria	201174|Actinobacteria	E	Aminotransferase class v	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
HKD2_k127_2777365_5	710111.FraQA3DRAFT_3503	1.059e-55	224.0	COG0346@1|root,COG0346@2|Bacteria,2IKP7@201174|Actinobacteria	201174|Actinobacteria	E	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HKD2_k127_2777365_3	1123023.JIAI01000001_gene5958	1.735e-87	295.0	COG0174@1|root,COG0174@2|Bacteria,2IFHQ@201174|Actinobacteria,4E3CW@85010|Pseudonocardiales	201174|Actinobacteria	E	DinB superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
HKD2_k127_2777365_11	1032480.MLP_34170	2.931e-28	119.0	COG1848@1|root,COG1848@2|Bacteria,2HMSG@201174|Actinobacteria,4DVFP@85009|Propionibacteriales	201174|Actinobacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2777365_1	1386089.N865_16800	1.734e-143	472.0	COG0438@1|root,COG0438@2|Bacteria,2ICGI@201174|Actinobacteria	201174|Actinobacteria	M	Glycosyl transferases group 1	-	-	2.4.1.245	ko:K13057	ko00500,ko01100,map00500,map01100	-	R08946,R10525,R11306	RC00005,RC00049,RC02748	ko00000,ko00001,ko01000	-	GT4	-	Glycos_transf_1,YHS
HKD2_k127_2777365_18	222534.KB893714_gene1597	5.386e-08	58.0	COG3311@1|root,COG3311@2|Bacteria	2|Bacteria	K	DNA excision	-	-	-	-	-	-	-	-	-	-	-	-	HTH_17
HKD2_k127_2777365_6	298653.Franean1_6648	5.23e-53	203.0	COG1396@1|root,COG1396@2|Bacteria,2GJBK@201174|Actinobacteria,4ETTN@85013|Frankiales	201174|Actinobacteria	K	SMART helix-turn-helix domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_31
HKD2_k127_2777365_12	1206743.BAGM01000059_gene5112	2.285e-17	82.0	2E6IT@1|root,3315W@2|Bacteria,2GTWB@201174|Actinobacteria,4G41Y@85025|Nocardiaceae	201174|Actinobacteria	S	Evidence 4 Homologs of previously reported genes of	-	-	-	-	-	-	-	-	-	-	-	-	DUF397
HKD2_k127_2777365_2	1157637.KB892146_gene7135	1.033e-98	336.0	COG1637@1|root,COG1637@2|Bacteria,2GIYB@201174|Actinobacteria	201174|Actinobacteria	L	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures	nucS	-	-	ko:K07503	-	-	-	-	ko00000,ko01000	-	-	-	NucS
HKD2_k127_2777365_8	656024.FsymDg_3834	2.345e-46	184.0	2BIEE@1|root,30G98@2|Bacteria,2I86Z@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2777365_17	1304275.C41B8_01827	2.526e-09	68.0	COG1011@1|root,COG1011@2|Bacteria,1MVWN@1224|Proteobacteria,1RR0H@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	haloacid dehalogenase	-	-	3.8.1.2	ko:K01560	ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120	-	R05287	RC00697	ko00000,ko00001,ko01000	-	-	-	HAD_2
HKD2_k127_2777365_9	665577.JH993790_gene5850	8.634e-36	140.0	COG1011@1|root,COG1011@2|Bacteria,2HHHH@201174|Actinobacteria	201174|Actinobacteria	S	haloacid dehalogenase	-	-	3.8.1.2	ko:K01560	ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120	-	R05287	RC00697	ko00000,ko00001,ko01000	-	-	-	HAD_2,Hydrolase
HKD2_k127_2778903_2	710111.FraQA3DRAFT_5757	1.976e-45	169.0	2E6D6@1|root,3310T@2|Bacteria,2H7NK@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2778903_1	656024.FsymDg_3734	9.05e-127	412.0	COG0179@1|root,COG0179@2|Bacteria,2GN2G@201174|Actinobacteria,4ERX7@85013|Frankiales	201174|Actinobacteria	Q	PFAM fumarylacetoacetate (FAA) hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	DUF2437,FAA_hydrolase
HKD2_k127_2778903_0	28042.GU90_18055	3.044e-129	440.0	COG0008@1|root,COG0008@2|Bacteria,2GJJS@201174|Actinobacteria,4E00Y@85010|Pseudonocardiales	201174|Actinobacteria	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	iNJ661.Rv2992c	tRNA-synt_1c
HKD2_k127_2778903_7	1298860.AUEM01000005_gene2736	0.0002478	46.0	COG1961@1|root,COG1961@2|Bacteria	2|Bacteria	L	recombinase activity	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
HKD2_k127_2778903_4	656024.FsymDg_3733	5.429e-21	93.0	COG0582@1|root,COG0582@2|Bacteria,2GJ2M@201174|Actinobacteria	201174|Actinobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
HKD2_k127_2778903_5	106370.Francci3_4210	1.84e-07	56.0	COG2826@1|root,COG2826@2|Bacteria,2GMZX@201174|Actinobacteria,4EUQP@85013|Frankiales	201174|Actinobacteria	L	PFAM Integrase catalytic region	-	-	-	ko:K07482	-	-	-	-	ko00000	-	-	-	HTH_38,rve
HKD2_k127_2779512_3	106370.Francci3_1402	3.042e-49	179.0	2E49S@1|root,32RRE@2|Bacteria,2I83P@201174|Actinobacteria,4ETFD@85013|Frankiales	201174|Actinobacteria	S	Protein of unknown function (DUF3040)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3040
HKD2_k127_2779512_0	298653.Franean1_5110	1.508e-194	641.0	COG1305@1|root,COG1305@2|Bacteria,2HQBB@201174|Actinobacteria,4ERJY@85013|Frankiales	201174|Actinobacteria	E	PFAM transglutaminase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF4129,Transglut_core
HKD2_k127_2779512_2	981369.JQMJ01000004_gene1958	3.115e-131	435.0	COG1721@1|root,COG1721@2|Bacteria,2GIWE@201174|Actinobacteria,2NETC@228398|Streptacidiphilus	201174|Actinobacteria	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
HKD2_k127_2779512_1	1120936.KB907210_gene5714	4.49e-145	478.0	COG0714@1|root,COG0714@2|Bacteria,2GK07@201174|Actinobacteria,4EHCA@85012|Streptosporangiales	201174|Actinobacteria	S	ATPase family associated with various cellular activities (AAA)	yeaC	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
HKD2_k127_2779512_4	65497.JODV01000001_gene3582	3.776e-18	99.0	COG0500@1|root,COG2226@2|Bacteria,2HIHA@201174|Actinobacteria,4DY0M@85010|Pseudonocardiales	201174|Actinobacteria	Q	Methylase involved in ubiquinone menaquinone biosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
HKD2_k127_2779512_5	1229205.BUPH_08527	2.976e-05	46.0	COG5659@1|root,COG5659@2|Bacteria,1MWAV@1224|Proteobacteria,2W56T@28216|Betaproteobacteria,1KIBA@119060|Burkholderiaceae	28216|Betaproteobacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5
HKD2_k127_2783133_8	58123.JOFJ01000015_gene4445	2.665e-12	68.0	COG1853@1|root,COG1853@2|Bacteria,2GMPH@201174|Actinobacteria,4EJKB@85012|Streptosporangiales	201174|Actinobacteria	S	Flavin reductase like domain	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
HKD2_k127_2783133_5	656024.FsymDg_2436	4.207e-32	130.0	COG0265@1|root,COG0265@2|Bacteria,2GNZT@201174|Actinobacteria,4EUA7@85013|Frankiales	201174|Actinobacteria	O	peptidase S1 and S6, chymotrypsin Hap	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
HKD2_k127_2783133_2	710111.FraQA3DRAFT_5499	2.573e-98	337.0	COG0265@1|root,COG0265@2|Bacteria,2GNZT@201174|Actinobacteria,4EUA7@85013|Frankiales	201174|Actinobacteria	O	peptidase S1 and S6, chymotrypsin Hap	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
HKD2_k127_2783133_6	526225.Gobs_2273	8.336e-30	128.0	COG1247@1|root,COG1247@2|Bacteria,2IMVR@201174|Actinobacteria,4EWXB@85013|Frankiales	201174|Actinobacteria	M	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HKD2_k127_2783133_4	28444.JODQ01000005_gene1288	9.478e-53	190.0	COG1733@1|root,COG1733@2|Bacteria,2IK2D@201174|Actinobacteria,4EIZC@85012|Streptosporangiales	201174|Actinobacteria	K	HxlR-like helix-turn-helix	-	-	-	-	-	-	-	-	-	-	-	-	HxlR
HKD2_k127_2783133_0	882083.SacmaDRAFT_3191	6.886e-139	462.0	2DBMB@1|root,2Z9Y8@2|Bacteria,2I4DG@201174|Actinobacteria,4EDSK@85010|Pseudonocardiales	201174|Actinobacteria	S	Domain of unknown function (DUF4389)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4389
HKD2_k127_2783133_1	656024.FsymDg_0838	7.865e-126	411.0	COG2120@1|root,COG2120@2|Bacteria,2GKUM@201174|Actinobacteria,4ES8C@85013|Frankiales	201174|Actinobacteria	S	Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway	mshB	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006790,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009987,GO:0010125,GO:0010126,GO:0016020,GO:0016137,GO:0016138,GO:0016787,GO:0016810,GO:0016811,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044272,GO:0044464,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:1901135,GO:1901137,GO:1901576,GO:1901657,GO:1901659	3.5.1.103	ko:K15525	-	-	-	-	ko00000,ko01000	-	-	-	PIG-L
HKD2_k127_2783133_3	1348663.KCH_31130	8.52e-85	299.0	COG0745@1|root,COG0745@2|Bacteria,2GP1I@201174|Actinobacteria,2M29Q@2063|Kitasatospora	201174|Actinobacteria	T	Transcriptional regulatory protein, C terminal	vicR	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
HKD2_k127_2785350_6	316274.Haur_1804	3.107e-14	74.0	COG1535@1|root,COG3433@1|root,COG1535@2|Bacteria,COG3433@2|Bacteria	2|Bacteria	Q	isochorismatase activity	entB	GO:0000287,GO:0003674,GO:0003824,GO:0004463,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008908,GO:0009058,GO:0009237,GO:0009238,GO:0009239,GO:0009712,GO:0009713,GO:0009987,GO:0016020,GO:0016740,GO:0016765,GO:0016787,GO:0016801,GO:0016803,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0018958,GO:0019184,GO:0019290,GO:0019438,GO:0019540,GO:0019748,GO:0019842,GO:0031177,GO:0033218,GO:0034641,GO:0036094,GO:0042802,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044550,GO:0046189,GO:0046483,GO:0046872,GO:0047527,GO:0048037,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:0072341,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	3.3.2.1,3.3.2.15,6.3.2.14	ko:K01252,ko:K20261	ko00405,ko01053,ko01110,ko01130,ko02024,map00405,map01053,map01110,map01130,map02024	M00835	R03037,R07644,R11463	RC00162,RC00350,RC02148,RC03046	ko00000,ko00001,ko00002,ko01000,ko01008	-	-	iSFV_1184.SFV_0543	Isochorismatase,PP-binding
HKD2_k127_2785350_5	351607.Acel_0530	2.934e-59	216.0	COG2353@1|root,COG2353@2|Bacteria,2GJFT@201174|Actinobacteria,4EX7D@85013|Frankiales	201174|Actinobacteria	S	Belongs to the UPF0312 family	-	-	-	-	-	-	-	-	-	-	-	-	YceI
HKD2_k127_2785350_2	1463857.JOFZ01000004_gene2555	1.109e-103	342.0	COG1028@1|root,COG1028@2|Bacteria,2GJU1@201174|Actinobacteria	201174|Actinobacteria	IQ	Short-chain dehydrogenase reductase sdr	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HKD2_k127_2785350_4	882083.SacmaDRAFT_4922	2.098e-73	253.0	COG1309@1|root,COG1309@2|Bacteria,2GJPK@201174|Actinobacteria,4E49J@85010|Pseudonocardiales	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	ko:K16137	-	-	-	-	ko00000,ko03000	-	-	-	TetR_C_13,TetR_C_6,TetR_N
HKD2_k127_2785350_3	479432.Sros_4259	4.983e-79	276.0	COG0477@1|root,COG0477@2|Bacteria,2I1IF@201174|Actinobacteria,4ENBC@85012|Streptosporangiales	201174|Actinobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD2_k127_2785350_0	68219.JNXI01000040_gene5489	3.125e-136	448.0	COG5002@1|root,COG5002@2|Bacteria,2GIX7@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
HKD2_k127_2785350_1	68219.JNXI01000040_gene5488	4.538e-111	363.0	COG0745@1|root,COG0745@2|Bacteria,2GJE6@201174|Actinobacteria	201174|Actinobacteria	T	Response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
HKD2_k127_2785396_4	2002.JOEQ01000030_gene2154	1.704e-28	127.0	COG4636@1|root,COG4636@2|Bacteria,2GRIW@201174|Actinobacteria,4EQY5@85012|Streptosporangiales	201174|Actinobacteria	S	Putative restriction endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	Uma2
HKD2_k127_2785396_3	298655.KI912266_gene504	2.749e-31	127.0	2DSW3@1|root,33HNJ@2|Bacteria,2I802@201174|Actinobacteria,4ETJE@85013|Frankiales	201174|Actinobacteria	S	Protein of unknown function (DUF3039)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3039
HKD2_k127_2785396_5	1172179.AUKV01000009_gene4378	4.536e-18	98.0	COG2203@1|root,COG2208@1|root,COG2203@2|Bacteria,COG2208@2|Bacteria,2ICPB@201174|Actinobacteria	201174|Actinobacteria	T	PAS domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HATPase_c_2,PAS_4,SpoIIE
HKD2_k127_2785396_1	219305.MCAG_03975	2.181e-164	528.0	COG2837@1|root,COG2837@2|Bacteria,2GIUB@201174|Actinobacteria,4D9M8@85008|Micromonosporales	201174|Actinobacteria	P	Dyp-type peroxidase family	efeN	-	-	ko:K16301	-	-	-	-	ko00000,ko01000,ko02000	2.A.108.2.3	-	-	Dyp_perox
HKD2_k127_2785396_0	298655.KI912266_gene486	1.612e-235	747.0	COG0672@1|root,COG2822@1|root,COG0672@2|Bacteria,COG2822@2|Bacteria,2GJPY@201174|Actinobacteria,4ESMR@85013|Frankiales	201174|Actinobacteria	P	Imelysin	efeO	-	-	ko:K07224	-	-	-	-	ko00000,ko02000	2.A.108.2.3	-	-	Cupredoxin_1,Peptidase_M75
HKD2_k127_2785396_2	106370.Francci3_0424	2.019e-80	273.0	COG1321@1|root,COG1321@2|Bacteria,2GKMC@201174|Actinobacteria,4ESDJ@85013|Frankiales	201174|Actinobacteria	K	PFAM iron dependent repressor	ideR	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005506,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006355,GO:0006518,GO:0006725,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008198,GO:0008270,GO:0009058,GO:0009237,GO:0009712,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016020,GO:0016151,GO:0018958,GO:0019184,GO:0019219,GO:0019222,GO:0019290,GO:0019540,GO:0019748,GO:0030145,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0034641,GO:0040007,GO:0043043,GO:0043167,GO:0043169,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0044550,GO:0045892,GO:0045934,GO:0046870,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0050897,GO:0051171,GO:0051172,GO:0051186,GO:0051188,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141	-	ko:K03709	-	-	-	-	ko00000,ko03000	-	-	-	Fe_dep_repr_C,Fe_dep_repress,FeoA
HKD2_k127_2790618_1	35754.JNYJ01000007_gene2729	7.722e-159	512.0	COG1109@1|root,COG1109@2|Bacteria,2GJ3Q@201174|Actinobacteria,4D9IA@85008|Micromonosporales	201174|Actinobacteria	G	Phosphoglucomutase phosphomannomutase alpha beta alpha domain I	pmmB	-	5.4.2.8	ko:K01840	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114	R01818	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
HKD2_k127_2790618_2	390989.JOEG01000003_gene4626	3.273e-86	293.0	COG0035@1|root,COG0035@2|Bacteria,2GPJE@201174|Actinobacteria,4DBBE@85008|Micromonosporales	201174|Actinobacteria	F	uracil phosphoribosyltransferase	upp	GO:0003674,GO:0003824,GO:0004849,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006206,GO:0006213,GO:0006220,GO:0006221,GO:0006222,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008655,GO:0009058,GO:0009112,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009173,GO:0009174,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0018130,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0043094,GO:0043097,GO:0043174,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046049,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.4.2.9	ko:K00761	ko00240,ko01100,map00240,map01100	-	R00966	RC00063	ko00000,ko00001,ko01000	-	-	-	UPRTase
HKD2_k127_2790618_3	266940.Krad_4162	1.972e-62	231.0	COG0274@1|root,COG0274@2|Bacteria,2GJIR@201174|Actinobacteria	201174|Actinobacteria	F	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate	deoC	GO:0003674,GO:0003824,GO:0004139,GO:0005975,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009166,GO:0009262,GO:0009264,GO:0009987,GO:0016052,GO:0016829,GO:0016830,GO:0016832,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576	4.1.2.4	ko:K01619	ko00030,map00030	-	R01066	RC00436,RC00437	ko00000,ko00001,ko01000	-	-	-	DeoC
HKD2_k127_2790618_0	298655.KI912266_gene232	5.135e-196	616.0	COG1816@1|root,COG1816@2|Bacteria,2GJ6I@201174|Actinobacteria,4ERVU@85013|Frankiales	201174|Actinobacteria	F	PFAM Adenosine AMP deaminase	add	GO:0003674,GO:0003824,GO:0004000,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006144,GO:0006152,GO:0006154,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009112,GO:0009113,GO:0009116,GO:0009119,GO:0009163,GO:0009164,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017144,GO:0018130,GO:0019239,GO:0019438,GO:0019439,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042278,GO:0042440,GO:0042451,GO:0042454,GO:0042455,GO:0042737,GO:0043094,GO:0043096,GO:0043101,GO:0043103,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046085,GO:0046100,GO:0046101,GO:0046102,GO:0046103,GO:0046112,GO:0046128,GO:0046129,GO:0046130,GO:0046148,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0072523,GO:1901135,GO:1901136,GO:1901137,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901657,GO:1901658,GO:1901659	3.5.4.4	ko:K01488	ko00230,ko01100,ko05340,map00230,map01100,map05340	-	R01560,R02556	RC00477	ko00000,ko00001,ko01000	-	-	iNJ661.Rv3313c	A_deaminase
HKD2_k127_2790618_4	656024.FsymDg_1002	1.52e-44	164.0	COG0213@1|root,COG0213@2|Bacteria,2GJH5@201174|Actinobacteria,4ERU2@85013|Frankiales	201174|Actinobacteria	F	TIGRFAM Pyrimidine-nucleoside phosphorylase	deoA	GO:0003674,GO:0003824,GO:0004645,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0009032,GO:0016740,GO:0016757,GO:0016758,GO:0016763,GO:0044424,GO:0044444,GO:0044464	2.4.2.2,2.4.2.4	ko:K00756,ko:K00758	ko00240,ko00983,ko01100,ko05219,map00240,map00983,map01100,map05219	-	R01570,R01876,R02296,R02484,R08222,R08230	RC00063	ko00000,ko00001,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3,PYNP_C
HKD2_k127_2859682_1	298655.KI912266_gene6551	2.007e-07	55.0	2DWSS@1|root,341Q8@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2859682_0	656024.FsymDg_1228	5.46e-255	802.0	COG0559@1|root,COG4177@1|root,COG0559@2|Bacteria,COG4177@2|Bacteria,2GJHR@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997,ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BPD_transp_2
HKD2_k127_2899183_2	469371.Tbis_1444	3.981e-164	527.0	COG1132@1|root,COG1132@2|Bacteria,2GITR@201174|Actinobacteria,4DYFV@85010|Pseudonocardiales	201174|Actinobacteria	V	ABC transporter transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
HKD2_k127_2899183_0	471852.Tcur_2882	1.402e-245	794.0	COG1132@1|root,COG1132@2|Bacteria,2GITR@201174|Actinobacteria,4EGNQ@85012|Streptosporangiales	201174|Actinobacteria	V	ABC transporter transmembrane region	-	-	-	ko:K02021,ko:K06147,ko:K16786,ko:K16787	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.106,3.A.1.109,3.A.1.110,3.A.1.112,3.A.1.113,3.A.1.117,3.A.1.21,3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	ABC_membrane,ABC_tran
HKD2_k127_2899183_3	298654.FraEuI1c_1304	2.384e-138	449.0	COG0627@1|root,COG0627@2|Bacteria,2GP6Q@201174|Actinobacteria,4ETSP@85013|Frankiales	201174|Actinobacteria	S	esterase	-	-	-	-	-	-	-	-	-	-	-	-	Esterase
HKD2_k127_2899183_6	351607.Acel_1070	3.688e-64	223.0	COG0139@1|root,COG0139@2|Bacteria,2IKKU@201174|Actinobacteria,4ESY0@85013|Frankiales	201174|Actinobacteria	E	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP	hisI	GO:0008150,GO:0040007	3.5.4.19,3.6.1.31	ko:K01496,ko:K11755	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04035,R04037	RC00002,RC01055	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv1606	PRA-CH
HKD2_k127_2899183_1	33876.JNXY01000044_gene1841	3.208e-199	642.0	COG0147@1|root,COG0147@2|Bacteria,2GKJT@201174|Actinobacteria,4D8F7@85008|Micromonosporales	201174|Actinobacteria	E	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia	trpE	-	4.1.3.27	ko:K01657	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
HKD2_k127_2899183_7	656024.FsymDg_2819	8.921e-52	196.0	2EGC7@1|root,33A40@2|Bacteria,2HEC9@201174|Actinobacteria,4ETGQ@85013|Frankiales	201174|Actinobacteria	S	Trp biosynthesis associated, transmembrane protein, Oprn Chp	-	-	-	-	-	-	-	-	-	-	-	-	Trp_oprn_chp
HKD2_k127_2899183_5	1352941.M877_21520	1.247e-72	261.0	COG4034@1|root,COG4034@2|Bacteria,2GM08@201174|Actinobacteria	201174|Actinobacteria	F	Protein of unknown function (DUF1152)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1152
HKD2_k127_2899183_4	326424.FRAAL1728	1.169e-97	328.0	COG2188@1|root,COG2188@2|Bacteria,2IAGW@201174|Actinobacteria,4EV99@85013|Frankiales	201174|Actinobacteria	K	UTRA	-	-	-	ko:K03710	-	-	-	-	ko00000,ko03000	-	-	-	GntR,UTRA
HKD2_k127_2899183_8	298655.KI912266_gene3679	6.051e-09	59.0	COG5542@1|root,COG5542@2|Bacteria	2|Bacteria	O	integral membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	Mannosyl_trans2
HKD2_k127_2931209_13	365528.KB891230_gene2036	1e-12	74.0	COG1475@1|root,COG1475@2|Bacteria,2GNRN@201174|Actinobacteria,4ERK5@85013|Frankiales	201174|Actinobacteria	K	Belongs to the ParB family	parB	GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005694,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044464,GO:0060187,GO:0071944	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
HKD2_k127_2931209_5	656024.FsymDg_4546	3.698e-144	466.0	COG1192@1|root,COG1192@2|Bacteria,2GMU7@201174|Actinobacteria,4ERFS@85013|Frankiales	201174|Actinobacteria	D	PFAM Cobyrinic acid a,c-diamide synthase	parA	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
HKD2_k127_2931209_7	298654.FraEuI1c_7200	5.297e-66	233.0	COG0357@1|root,COG0357@2|Bacteria,2GM9Z@201174|Actinobacteria,4ESR1@85013|Frankiales	201174|Actinobacteria	J	Specifically methylates the N7 position of a guanine in 16S rRNA	rsmG	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036265,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070043,GO:0070475,GO:0070476,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.170	ko:K03501	-	-	-	-	ko00000,ko01000,ko03009,ko03036	-	-	-	GidB
HKD2_k127_2931209_8	656024.FsymDg_0001	2.589e-65	231.0	COG1847@1|root,COG1847@2|Bacteria,2GPZK@201174|Actinobacteria,4ESQX@85013|Frankiales	201174|Actinobacteria	S	PFAM Single-stranded nucleic acid binding R3H	jag	-	-	ko:K06346	-	-	-	-	ko00000	-	-	-	KH_4,R3H
HKD2_k127_2931209_6	222534.KB893717_gene2027	2.108e-122	411.0	COG0706@1|root,COG0706@2|Bacteria,2GJBU@201174|Actinobacteria,4ESJC@85013|Frankiales	201174|Actinobacteria	U	PFAM 60 kDa inner membrane insertion protein	yidC	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03029	2.A.9	-	-	60KD_IMP
HKD2_k127_2931209_11	266940.Krad_4511	3.446e-23	104.0	COG0759@1|root,COG0759@2|Bacteria,2GQZG@201174|Actinobacteria	201174|Actinobacteria	S	Could be involved in insertion of integral membrane proteins into the membrane	ytjA	-	-	ko:K08998	-	-	-	-	ko00000	-	-	-	Haemolytic
HKD2_k127_2931209_10	710111.FraQA3DRAFT_4875	1.328e-25	116.0	COG0594@1|root,COG0594@2|Bacteria	2|Bacteria	J	ribonuclease P activity	rnpA	GO:0000966,GO:0001682,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005655,GO:0005730,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0030677,GO:0030681,GO:0031123,GO:0031404,GO:0031974,GO:0031981,GO:0032991,GO:0033204,GO:0034414,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0040007,GO:0042301,GO:0042779,GO:0042780,GO:0042781,GO:0043167,GO:0043168,GO:0043170,GO:0043199,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043628,GO:0044237,GO:0044238,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044452,GO:0044464,GO:0046483,GO:0070013,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0099116,GO:0140098,GO:0140101,GO:1901360,GO:1901363,GO:1901681,GO:1902494,GO:1902555,GO:1905267,GO:1905348,GO:1990904	3.1.26.5	ko:K03536,ko:K08998	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Ribonuclease_P
HKD2_k127_2931209_12	446466.Cfla_3730	3.628e-16	83.0	COG0230@1|root,COG0230@2|Bacteria,2GQFY@201174|Actinobacteria	201174|Actinobacteria	J	Belongs to the bacterial ribosomal protein bL34 family	rpmH	-	-	ko:K02914	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L34
HKD2_k127_2931209_1	351607.Acel_0001	1.66e-186	620.0	COG0593@1|root,COG0593@2|Bacteria,2GJKI@201174|Actinobacteria,4ES24@85013|Frankiales	201174|Actinobacteria	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids	dnaA	GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006172,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009133,GO:0009135,GO:0009136,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009179,GO:0009180,GO:0009185,GO:0009188,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016311,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046031,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090304,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990837	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA,Bac_DnaA_C
HKD2_k127_2931209_2	656024.FsymDg_0007	5.03e-176	559.0	COG0592@1|root,COG0592@2|Bacteria,2GJK3@201174|Actinobacteria,4ES2Y@85013|Frankiales	201174|Actinobacteria	L	Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria	dnaN	GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	2.7.7.7	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3
HKD2_k127_2931209_4	479432.Sros_0004	1.847e-147	473.0	COG1023@1|root,COG1023@2|Bacteria,2I2DH@201174|Actinobacteria,4EHS7@85012|Streptosporangiales	201174|Actinobacteria	G	6-phosphogluconate dehydrogenase, C-terminal domain	gnd	-	1.1.1.343,1.1.1.44	ko:K00033	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200	M00004,M00006	R01528,R10221	RC00001,RC00539	ko00000,ko00001,ko00002,ko01000	-	-	-	6PGD,NAD_binding_2
HKD2_k127_2931209_3	106370.Francci3_0004	2.768e-151	489.0	COG1195@1|root,COG1195@2|Bacteria,2GJCS@201174|Actinobacteria,4ES7H@85013|Frankiales	201174|Actinobacteria	L	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP	recF	GO:0000731,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0018130,GO:0019438,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:1901360,GO:1901362,GO:1901576	-	ko:K03629	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	SMC_N
HKD2_k127_2931209_9	656024.FsymDg_0009	6.706e-51	199.0	COG5512@1|root,COG5512@2|Bacteria,2GNQ4@201174|Actinobacteria,4ET6F@85013|Frankiales	201174|Actinobacteria	S	Protein of unknown function (DUF721)	-	-	-	-	-	-	-	-	-	-	-	-	DUF721
HKD2_k127_2931209_0	656024.FsymDg_0010	0.0	1127.0	COG0187@1|root,COG0187@2|Bacteria,2GKGP@201174|Actinobacteria,4ES0Z@85013|Frankiales	201174|Actinobacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0003916,GO:0003918,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006265,GO:0006725,GO:0006807,GO:0006996,GO:0007059,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009295,GO:0009987,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017076,GO:0017111,GO:0030312,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034335,GO:0034641,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0046872,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
HKD2_k127_2955045_4	1150864.MILUP08_46199	2.677e-31	133.0	COG1983@1|root,COG3266@1|root,COG1983@2|Bacteria,COG3266@2|Bacteria,2GIVS@201174|Actinobacteria,4DAQE@85008|Micromonosporales	201174|Actinobacteria	KT	PspC domain	pspC	-	-	-	-	-	-	-	-	-	-	-	DUF2154,PspC
HKD2_k127_2955045_0	1283299.AUKG01000001_gene1933	5.45e-253	790.0	COG0028@1|root,COG0028@2|Bacteria,2GKU4@201174|Actinobacteria,4CR1V@84995|Rubrobacteria	84995|Rubrobacteria	EH	Thiamine pyrophosphate enzyme, central domain	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
HKD2_k127_2955045_5	710111.FraQA3DRAFT_5561	1.446e-21	103.0	2C4RB@1|root,2ZVRN@2|Bacteria,2HAZK@201174|Actinobacteria,4EWZ7@85013|Frankiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2955045_1	656024.FsymDg_0894	5.364e-122	397.0	COG1192@1|root,COG1192@2|Bacteria,2GNEQ@201174|Actinobacteria	201174|Actinobacteria	D	Cobyrinic acid ac-diamide synthase	-	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
HKD2_k127_2955045_2	656024.FsymDg_0890	6.798e-99	340.0	COG3662@1|root,COG3662@2|Bacteria,2GJD2@201174|Actinobacteria,4ESC5@85013|Frankiales	201174|Actinobacteria	S	Uncharacterized protein conserved in bacteria (DUF2236)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2236
HKD2_k127_2955045_3	215803.DB30_8813	9.032e-39	153.0	COG3409@1|root,COG3409@2|Bacteria,1N9AN@1224|Proteobacteria,42XYC@68525|delta/epsilon subdivisions,2WSN6@28221|Deltaproteobacteria,2YZQ1@29|Myxococcales	28221|Deltaproteobacteria	M	Putative peptidoglycan binding domain	-	-	-	ko:K17733	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	PG_binding_1,VanY
HKD2_k127_3005677_10	1206739.BAGJ01000250_gene4817	1.891e-10	61.0	COG3293@1|root,COG3293@2|Bacteria,2IIAY@201174|Actinobacteria,4G1V8@85025|Nocardiaceae	201174|Actinobacteria	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_2,DUF4096
HKD2_k127_3005677_9	875328.JDM601_0583	4.298e-18	87.0	2ERR5@1|root,33JAC@2|Bacteria,2H116@201174|Actinobacteria,23EAS@1762|Mycobacteriaceae	201174|Actinobacteria	-	-	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3005677_3	351607.Acel_1699	5.353e-170	552.0	COG0535@1|root,COG0535@2|Bacteria,2HTDD@201174|Actinobacteria,4ES4M@85013|Frankiales	201174|Actinobacteria	F	PFAM Radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF3463,Fer4_14,Radical_SAM
HKD2_k127_3005677_1	298655.KI912266_gene11	3.443e-185	624.0	COG0761@1|root,COG0775@1|root,COG0761@2|Bacteria,COG0775@2|Bacteria,2GIZ7@201174|Actinobacteria,4ES7R@85013|Frankiales	201174|Actinobacteria	IM	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis	ispH	-	1.17.7.4	ko:K03527	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05884,R08210	RC01137,RC01487	ko00000,ko00001,ko00002,ko01000	-	-	-	LYTB,PNP_UDP_1
HKD2_k127_3005677_0	656024.FsymDg_1170	1.183e-300	932.0	COG1657@1|root,COG1657@2|Bacteria,2GM7H@201174|Actinobacteria,4ES7V@85013|Frankiales	201174|Actinobacteria	I	Squalene--hopene cyclase	shc1	-	4.2.1.129,5.4.99.17	ko:K06045	ko00909,ko01110,map00909,map01110	-	R07322,R07323	RC01850,RC01851	ko00000,ko00001,ko01000	-	-	-	SQHop_cyclase_C,SQHop_cyclase_N
HKD2_k127_3005677_4	656024.FsymDg_1169	3.931e-133	447.0	COG0142@1|root,COG0142@2|Bacteria,2GN1P@201174|Actinobacteria,4ESDC@85013|Frankiales	201174|Actinobacteria	H	Belongs to the FPP GGPP synthase family	-	-	2.5.1.1,2.5.1.10,2.5.1.29	ko:K13787	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00365	R01658,R02003,R02061	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
HKD2_k127_3005677_2	656024.FsymDg_1168	1.057e-180	582.0	COG1232@1|root,COG1232@2|Bacteria,2I2Z5@201174|Actinobacteria,4ERME@85013|Frankiales	201174|Actinobacteria	H	PFAM amine oxidase	hopC	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
HKD2_k127_3005677_5	710111.FraQA3DRAFT_3538	3.525e-111	379.0	COG1562@1|root,COG1562@2|Bacteria,2GJN2@201174|Actinobacteria	201174|Actinobacteria	I	phytoene synthase	crtB	GO:0003674,GO:0003824,GO:0004337,GO:0004659,GO:0006629,GO:0006720,GO:0006721,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016108,GO:0016109,GO:0016114,GO:0016116,GO:0016117,GO:0016740,GO:0016765,GO:0016767,GO:0042440,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046148,GO:0071704,GO:1901576	2.5.1.32,2.5.1.99	ko:K02291	ko00906,ko01062,ko01100,ko01110,map00906,map01062,map01100,map01110	M00097	R02065,R04218,R07270,R10177	RC00362,RC01101,RC02869	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	SQS_PSY
HKD2_k127_3005677_7	656024.FsymDg_1166	1.936e-96	329.0	COG1562@1|root,COG1562@2|Bacteria,2GNS9@201174|Actinobacteria,4EV51@85013|Frankiales	201174|Actinobacteria	I	PFAM Squalene phytoene synthase	hopE	-	-	-	-	-	-	-	-	-	-	-	SQS_PSY
HKD2_k127_3005677_6	562973.HMPREF0059_01019	4.663e-111	392.0	COG0640@1|root,COG2865@1|root,COG0640@2|Bacteria,COG2865@2|Bacteria,2IB2P@201174|Actinobacteria,4D4XM@85005|Actinomycetales	201174|Actinobacteria	K	Putative ATP-dependent DNA helicase recG C-terminal	-	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AlbA_2,HATPase_c_4,HTH_24,HTH_5,HTH_IclR,MarR
HKD2_k127_3005677_8	235985.BBPN01000022_gene2463	8.949e-58	209.0	COG1520@1|root,COG1520@2|Bacteria,2I9FJ@201174|Actinobacteria,2NH50@228398|Streptacidiphilus	201174|Actinobacteria	S	PQQ-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2,PQQ_3
HKD2_k127_3014164_1	378806.STAUR_3140	6.453e-105	354.0	COG0337@1|root,COG0337@2|Bacteria,1MUBK@1224|Proteobacteria,42MW5@68525|delta/epsilon subdivisions,2WJKR@28221|Deltaproteobacteria,2YV4V@29|Myxococcales	28221|Deltaproteobacteria	H	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)	aroB	-	2.7.1.71,4.2.3.4	ko:K01735,ko:K13829	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412,R03083	RC00002,RC00078,RC00847	ko00000,ko00001,ko00002,ko01000	-	-	-	DHQ_synthase,SKI
HKD2_k127_3014164_0	378806.STAUR_3139	2.534e-113	373.0	COG1082@1|root,COG1082@2|Bacteria,1MW1Z@1224|Proteobacteria	1224|Proteobacteria	G	sugar phosphate	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2,AP_endonuc_2_N
HKD2_k127_3014164_4	751945.Theos_0839	4.706e-33	147.0	COG1085@1|root,COG1085@2|Bacteria,1WI1W@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	G	PFAM Galactose-1-phosphate uridyl transferase, C-terminal domain	-	-	2.7.7.12	ko:K00965	ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917	M00362,M00554,M00632	R00955	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	GalP_UDP_tr_C,GalP_UDP_transf
HKD2_k127_3014164_2	446462.Amir_1998	7.711e-77	286.0	COG1091@1|root,COG1091@2|Bacteria,2HQPH@201174|Actinobacteria,4E9IW@85010|Pseudonocardiales	201174|Actinobacteria	M	GDP-mannose 4,6 dehydratase	-	-	-	ko:K20432	ko00525,ko01130,map00525,map01130	M00815	R11233	RC03398	ko00000,ko00001,ko00002,ko01000	-	-	-	RmlD_sub_bind
HKD2_k127_3014164_3	1242864.D187_007837	1.264e-71	250.0	COG0380@1|root,COG0380@2|Bacteria,1MUIY@1224|Proteobacteria,42NBU@68525|delta/epsilon subdivisions,2WJX9@28221|Deltaproteobacteria,2YU3V@29|Myxococcales	28221|Deltaproteobacteria	G	glycosyl transferase family	-	-	2.5.1.135	ko:K20436	ko00525,ko01130,map00525,map01130	M00815	R11239,R11250,R11497	RC03400,RC03401	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyco_transf_20
HKD2_k127_3017512_3	710111.FraQA3DRAFT_2839	1.248e-44	168.0	2EGQJ@1|root,33AGQ@2|Bacteria,2IADM@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3017512_2	656024.FsymDg_3043	5.19e-95	332.0	COG0842@1|root,COG0842@2|Bacteria,2GN6V@201174|Actinobacteria,4EV70@85013|Frankiales	201174|Actinobacteria	V	PFAM ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
HKD2_k127_3017512_0	222534.KB893671_gene3303	1.797e-153	490.0	COG1131@1|root,COG1131@2|Bacteria,2GJ84@201174|Actinobacteria,4EUZR@85013|Frankiales	201174|Actinobacteria	V	PFAM ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD2_k127_3017512_1	656024.FsymDg_3045	1.042e-104	346.0	COG1215@1|root,COG1215@2|Bacteria,2GP1D@201174|Actinobacteria	201174|Actinobacteria	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HKD2_k127_3017512_4	1121926.AXWO01000001_gene3644	4.907e-19	90.0	2DMWY@1|root,32U6G@2|Bacteria,2ISFN@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3017616_4	656024.FsymDg_1337	1.039e-54	198.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,2GIV0@201174|Actinobacteria,4ES3X@85013|Frankiales	201174|Actinobacteria	KLT	Serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Pkinase
HKD2_k127_3017616_5	1394178.AWOO02000103_gene5705	3.863e-51	186.0	COG0517@1|root,COG0517@2|Bacteria,2IHPB@201174|Actinobacteria,4EJNY@85012|Streptosporangiales	201174|Actinobacteria	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
HKD2_k127_3017616_1	1121033.AUCF01000046_gene535	2.464e-124	414.0	COG2327@1|root,COG2327@2|Bacteria,1PHG0@1224|Proteobacteria,2VC58@28211|Alphaproteobacteria,2JXX1@204441|Rhodospirillales	204441|Rhodospirillales	S	Polysaccharide pyruvyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	PS_pyruv_trans
HKD2_k127_3017616_0	471852.Tcur_2272	2.114e-214	674.0	COG0644@1|root,COG0644@2|Bacteria,2I38R@201174|Actinobacteria,4EPU5@85012|Streptosporangiales	201174|Actinobacteria	C	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_oxidored
HKD2_k127_3017616_8	478801.Ksed_21560	2.619e-18	93.0	COG1876@1|root,COG1876@2|Bacteria,2GT9Z@201174|Actinobacteria,1ZX22@145357|Dermacoccaceae	201174|Actinobacteria	M	D-alanyl-D-alanine carboxypeptidase	-	-	-	-	-	-	-	-	-	-	-	-	VanY
HKD2_k127_3017616_2	309801.trd_0023	1.687e-104	359.0	COG0309@1|root,COG0309@2|Bacteria,2G7TM@200795|Chloroflexi,27XK5@189775|Thermomicrobia	189775|Thermomicrobia	O	AIR synthase related protein, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AIRS,AIRS_C
HKD2_k127_3017616_7	1146883.BLASA_0101	3.254e-33	136.0	COG0352@1|root,COG0352@2|Bacteria,2GKCN@201174|Actinobacteria,4ESI0@85013|Frankiales	201174|Actinobacteria	H	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)	thiE	-	2.5.1.3	ko:K00788	ko00730,ko01100,map00730,map01100	M00127	R03223,R10712	RC00224,RC03255,RC03397	ko00000,ko00001,ko00002,ko01000	-	-	-	TMP-TENI
HKD2_k127_3017616_6	479433.Caci_6206	4.071e-51	198.0	2EFBW@1|root,3394U@2|Bacteria,2H758@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3017616_3	66373.JOFQ01000011_gene7012	5.281e-97	331.0	COG4552@1|root,COG4552@2|Bacteria,2GNXZ@201174|Actinobacteria	201174|Actinobacteria	S	N-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_9,SCP2_2
HKD2_k127_3017616_9	710111.FraQA3DRAFT_2827	8.616e-07	54.0	COG2161@1|root,COG2161@2|Bacteria	2|Bacteria	D	toxin-antitoxin pair type II binding	-	-	-	ko:K19159	-	-	-	-	ko00000,ko02048	-	-	-	PhdYeFM_antitox
HKD2_k127_3017725_11	1343740.M271_19225	6.173e-26	111.0	COG1961@1|root,COG1961@2|Bacteria,2I8IZ@201174|Actinobacteria	201174|Actinobacteria	L	Site-specific recombinases, DNA invertase Pin homologs	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
HKD2_k127_3017725_13	1214242.B446_20030	4.71e-14	78.0	COG1961@1|root,COG1961@2|Bacteria,2I8IZ@201174|Actinobacteria	201174|Actinobacteria	L	Site-specific recombinases, DNA invertase Pin homologs	int11	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
HKD2_k127_3017725_8	28444.JODQ01000014_gene6678	3.522e-61	220.0	COG1961@1|root,COG1961@2|Bacteria,2I8IZ@201174|Actinobacteria,4EKAQ@85012|Streptosporangiales	201174|Actinobacteria	L	Recombinase	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
HKD2_k127_3017725_10	351607.Acel_1378	9.562e-30	121.0	COG3285@1|root,COG3285@2|Bacteria,2GM0A@201174|Actinobacteria,4ES0F@85013|Frankiales	201174|Actinobacteria	L	DNA polymerase LigD	ligD	-	-	-	-	-	-	-	-	-	-	-	DNA_primase_S
HKD2_k127_3017725_5	298654.FraEuI1c_0191	4.208e-135	455.0	COG2976@1|root,COG2976@2|Bacteria,2GNIS@201174|Actinobacteria,4ETXP@85013|Frankiales	201174|Actinobacteria	S	Protein of unknown function (DUF4012)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4012
HKD2_k127_3017725_6	298655.KI912266_gene5249	8.583e-118	383.0	COG3253@1|root,COG3253@2|Bacteria,2GK24@201174|Actinobacteria,4ESCK@85013|Frankiales	201174|Actinobacteria	S	PFAM Chlorite dismutase	cld	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Chlor_dismutase
HKD2_k127_3017725_12	2002.JOEQ01000002_gene4544	1.02e-21	103.0	COG0542@1|root,COG0542@2|Bacteria,2GJ77@201174|Actinobacteria,4EGP6@85012|Streptosporangiales	201174|Actinobacteria	O	Clp amino terminal domain, pathogenicity island component	-	-	-	ko:K03696	ko01100,map01100	-	-	-	ko00000,ko03110	-	-	-	AAA,Clp_N,Peptidase_C14,TIR_2
HKD2_k127_3017725_2	326424.FRAAL2102	2.683e-172	564.0	COG1232@1|root,COG1232@2|Bacteria,2GMMA@201174|Actinobacteria,4ERN3@85013|Frankiales	201174|Actinobacteria	H	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX	hemG	-	1.3.3.15,1.3.3.4	ko:K00231	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03222,R04178	RC00885	ko00000,ko00001,ko00002,ko01000	-	-	-	Amino_oxidase
HKD2_k127_3017725_3	710111.FraQA3DRAFT_2950	1.272e-158	513.0	COG0407@1|root,COG0407@2|Bacteria,2GMY6@201174|Actinobacteria,4ERPI@85013|Frankiales	201174|Actinobacteria	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	hemE	GO:0003674,GO:0003824,GO:0004853,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
HKD2_k127_3017725_7	656024.FsymDg_1820	5.189e-65	229.0	2AIF4@1|root,318WM@2|Bacteria,2GK8R@201174|Actinobacteria,4ET1T@85013|Frankiales	201174|Actinobacteria	S	Protein of unknown function (DUF3000)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3000
HKD2_k127_3017725_1	365528.KB891102_gene4504	7.292e-175	557.0	COG0349@1|root,COG0349@2|Bacteria,2GKNM@201174|Actinobacteria,4ERGX@85013|Frankiales	201174|Actinobacteria	L	3'-5' exonuclease	rnd	-	3.1.13.5	ko:K03684	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DNA_pol_A_exo1,HRDC
HKD2_k127_3017725_9	1048339.KB913029_gene1837	3.16e-33	134.0	COG1670@1|root,COG1670@2|Bacteria,2IIEK@201174|Actinobacteria,4EWXE@85013|Frankiales	201174|Actinobacteria	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
HKD2_k127_3017725_0	222534.KB893671_gene3193	1.944e-210	674.0	COG0183@1|root,COG0183@2|Bacteria,2GJAC@201174|Actinobacteria,4ERTH@85013|Frankiales	201174|Actinobacteria	I	Belongs to the thiolase family	fadA	-	2.3.1.16,2.3.1.9	ko:K00626,ko:K00632	ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00087,M00088,M00095,M00113,M00373,M00374,M00375	R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
HKD2_k127_3017725_4	710111.FraQA3DRAFT_2957	3.985e-152	508.0	COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,2GJ50@201174|Actinobacteria,4ES2P@85013|Frankiales	201174|Actinobacteria	I	3-hydroxyacyl-CoA dehydrogenase	fadB	-	1.1.1.35,4.2.1.17,5.1.2.3	ko:K01782	ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212	M00032,M00087	R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094	RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	3HCDH,3HCDH_N,ECH_1
HKD2_k127_3017755_2	1101188.KI912156_gene3829	2.762e-14	75.0	COG2026@1|root,COG2026@2|Bacteria,2IRES@201174|Actinobacteria,1WABI@1268|Micrococcaceae	201174|Actinobacteria	DJ	ParE toxin of type II toxin-antitoxin system, parDE	-	-	-	ko:K06218	-	-	-	-	ko00000,ko02048	-	-	-	ParE_toxin
HKD2_k127_3017755_3	1150398.JIBJ01000002_gene1164	7.299e-11	71.0	COG2453@1|root,COG2453@2|Bacteria,2IHXA@201174|Actinobacteria	201174|Actinobacteria	T	phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Y_phosphatase
HKD2_k127_3017755_0	1123023.JIAI01000014_gene3661	2.807e-60	218.0	COG1280@1|root,COG1280@2|Bacteria,2ICJX@201174|Actinobacteria,4E35B@85010|Pseudonocardiales	201174|Actinobacteria	E	LysE type translocator	-	-	-	-	-	-	-	-	-	-	-	-	LysE
HKD2_k127_3017755_1	1206741.BAFX01000046_gene3206	4.925e-25	114.0	COG3386@1|root,COG3386@2|Bacteria,2HI5X@201174|Actinobacteria,4G2XX@85025|Nocardiaceae	201174|Actinobacteria	G	SMP-30/Gluconolaconase/LRE-like region	-	-	-	ko:K14274	ko00040,map00040	-	R02427	RC00713	ko00000,ko00001,ko01000	-	-	-	SGL
HKD2_k127_304978_3	365528.KB891223_gene1304	2.34e-128	412.0	COG0504@1|root,COG0504@2|Bacteria,2GJ13@201174|Actinobacteria,4ERGE@85013|Frankiales	201174|Actinobacteria	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv1699	CTP_synth_N,GATase
HKD2_k127_304978_0	656024.FsymDg_3252	7.321e-238	749.0	COG0497@1|root,COG0497@2|Bacteria,2GIVG@201174|Actinobacteria,4ERH7@85013|Frankiales	201174|Actinobacteria	L	May be involved in recombinational repair of damaged DNA	recN	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	-	ko:K03631	-	-	-	-	ko00000,ko03400	-	-	-	AAA_23,SMC_N
HKD2_k127_304978_2	656024.FsymDg_3253	1.284e-136	443.0	COG0061@1|root,COG0061@2|Bacteria,2GKM2@201174|Actinobacteria,4ERHI@85013|Frankiales	201174|Actinobacteria	G	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	nadK	GO:0000166,GO:0003674,GO:0003824,GO:0003951,GO:0005488,GO:0005524,GO:0006082,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006741,GO:0006753,GO:0006793,GO:0006796,GO:0006797,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046496,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0051287,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	NAD_kinase
HKD2_k127_304978_5	710111.FraQA3DRAFT_6346	2.638e-102	339.0	COG1189@1|root,COG1189@2|Bacteria,2GJVT@201174|Actinobacteria,4ES4X@85013|Frankiales	201174|Actinobacteria	J	Ribosomal RNA methyltransferase RrmJ FtsJ	tlyA	GO:0000154,GO:0001510,GO:0001897,GO:0001906,GO:0001907,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0019835,GO:0019836,GO:0022613,GO:0031167,GO:0031640,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0035821,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044003,GO:0044004,GO:0044085,GO:0044179,GO:0044237,GO:0044238,GO:0044260,GO:0044364,GO:0044403,GO:0044419,GO:0044764,GO:0046483,GO:0051701,GO:0051704,GO:0051715,GO:0051801,GO:0051817,GO:0051818,GO:0051883,GO:0052331,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.226,2.1.1.227	ko:K06442	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ,S4
HKD2_k127_304978_10	1122182.KB903838_gene3977	1.501e-17	96.0	COG3937@1|root,COG3937@2|Bacteria,2ISFA@201174|Actinobacteria,4DEZR@85008|Micromonosporales	201174|Actinobacteria	S	granule-associated protein	-	-	-	-	-	-	-	-	-	-	-	-	Phasin
HKD2_k127_304978_8	298653.Franean1_1750	5.085e-31	138.0	COG3255@1|root,COG3255@2|Bacteria,2IM6I@201174|Actinobacteria,4ETJH@85013|Frankiales	201174|Actinobacteria	I	Sterol carrier protein	-	-	-	-	-	-	-	-	-	-	-	-	SCP2
HKD2_k127_304978_4	298653.Franean1_1749	1.631e-119	396.0	COG0647@1|root,COG0647@2|Bacteria,2GK7V@201174|Actinobacteria,4ESEC@85013|Frankiales	201174|Actinobacteria	G	PFAM Haloacid dehalogenase domain protein hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_6,Hydrolase_like
HKD2_k127_304978_7	656024.FsymDg_3258	1.544e-56	205.0	COG3118@1|root,COG3118@2|Bacteria,2I6PE@201174|Actinobacteria	201174|Actinobacteria	O	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_304978_1	656024.FsymDg_3259	2.075e-163	536.0	COG4198@1|root,COG4198@2|Bacteria,2GJFV@201174|Actinobacteria,4ESHT@85013|Frankiales	201174|Actinobacteria	S	Protein of unknown function (DUF1015)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1015
HKD2_k127_304978_11	1385519.N801_19075	3.145e-09	63.0	COG0629@1|root,COG0629@2|Bacteria,2GRPQ@201174|Actinobacteria	201174|Actinobacteria	L	Single-stranded DNA-binding protein	-	-	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
HKD2_k127_304978_6	656024.FsymDg_3267	3.849e-69	247.0	COG0457@1|root,COG0457@2|Bacteria,2GKX5@201174|Actinobacteria,4ESUY@85013|Frankiales	201174|Actinobacteria	S	PFAM Pentapeptide repeats (8 copies)	-	-	-	-	-	-	-	-	-	-	-	-	TPR_19
HKD2_k127_304978_9	411459.RUMOBE_04123	7.139e-24	106.0	2EU6P@1|root,33MP7@2|Bacteria,1VM14@1239|Firmicutes,24U4C@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3055245_2	591167.Sfla_4326	5.142e-30	130.0	COG1022@1|root,COG1022@2|Bacteria,2GIXQ@201174|Actinobacteria	201174|Actinobacteria	I	AMP-dependent synthetase and ligase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
HKD2_k127_3055245_0	298654.FraEuI1c_6131	2.262e-111	366.0	COG0005@1|root,COG0005@2|Bacteria,2GKEI@201174|Actinobacteria,4ESDS@85013|Frankiales	201174|Actinobacteria	F	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate	punA	GO:0003674,GO:0003824,GO:0004731,GO:0006139,GO:0006152,GO:0006161,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009116,GO:0009120,GO:0009164,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0019439,GO:0034641,GO:0034655,GO:0034656,GO:0042278,GO:0042453,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0046121,GO:0046122,GO:0046124,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901657,GO:1901658	2.4.2.1	ko:K03783	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R01561,R01863,R01969,R02147,R02294,R02295,R02297,R02484,R02557,R02748,R08368,R10244	RC00033,RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	PNP_UDP_1
HKD2_k127_3055245_1	1463856.JOHY01000011_gene6890	4.335e-47	172.0	COG1109@1|root,COG1109@2|Bacteria,2GJ3Q@201174|Actinobacteria	201174|Actinobacteria	G	phosphoglucomutase phosphomannomutase alpha beta alpha domain II	pmmB	-	5.4.2.2,5.4.2.8	ko:K01835,ko:K01840	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114,M00549	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
HKD2_k127_3062643_3	469371.Tbis_1422	4.846e-33	131.0	COG0210@1|root,COG1379@1|root,COG0210@2|Bacteria,COG1379@2|Bacteria,2I12T@201174|Actinobacteria,4DX7Y@85010|Pseudonocardiales	201174|Actinobacteria	L	UvrD/REP helicase N-terminal domain	pcrA	-	-	-	-	-	-	-	-	-	-	-	UvrD-helicase,UvrD_C
HKD2_k127_3062643_1	471852.Tcur_1520	1.706e-56	202.0	2BVHN@1|root,332R2@2|Bacteria,2IPM7@201174|Actinobacteria	201174|Actinobacteria	S	F420H(2)-dependent quinone reductase	-	-	-	-	-	-	-	-	-	-	-	-	F420H2_quin_red
HKD2_k127_3062643_0	1136417.AZWE01000068_gene637	2.39e-73	257.0	COG1011@1|root,COG1011@2|Bacteria,2GPJ4@201174|Actinobacteria,4DAVQ@85008|Micromonosporales	201174|Actinobacteria	S	Had-superfamily hydrolase, subfamily ia, variant 1	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2,Hydrolase,Hydrolase_like
HKD2_k127_3062643_2	298655.KI912266_gene3228	9.71e-49	186.0	COG1051@1|root,COG1051@2|Bacteria,2I8YY@201174|Actinobacteria	201174|Actinobacteria	F	Belongs to the NUDIX hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
HKD2_k127_3063888_2	1137271.AZUM01000001_gene1499	0.0001189	52.0	COG2267@1|root,COG2267@2|Bacteria,2I9MH@201174|Actinobacteria,4E3GU@85010|Pseudonocardiales	201174|Actinobacteria	I	carboxylic ester hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
HKD2_k127_3063888_0	656024.FsymDg_1809	1.248e-50	196.0	28J4D@1|root,2Z90C@2|Bacteria,2GJYC@201174|Actinobacteria,4ET3P@85013|Frankiales	201174|Actinobacteria	S	Protein of unknown function (DUF3710)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3710
HKD2_k127_3063888_1	1454010.JEOE01000001_gene654	1.761e-20	95.0	COG1192@1|root,COG1192@2|Bacteria,2H4UC@201174|Actinobacteria	201174|Actinobacteria	D	chromosome partitioning	-	-	-	-	-	-	-	-	-	-	-	-	AAA_31
HKD2_k127_3128875_3	1449346.JQMO01000003_gene3059	3.481e-22	103.0	COG0330@1|root,COG0330@2|Bacteria,2GKFP@201174|Actinobacteria,2M13B@2063|Kitasatospora	201174|Actinobacteria	O	prohibitin homologues	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
HKD2_k127_3128875_1	106370.Francci3_4280	4.474e-146	471.0	COG0003@1|root,COG0003@2|Bacteria,2GJ0J@201174|Actinobacteria,4ERDW@85013|Frankiales	201174|Actinobacteria	P	Anion-transporting ATPase	arsA_2	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	ArsA_ATPase
HKD2_k127_3128875_0	106370.Francci3_4279	7.734e-180	589.0	COG0003@1|root,COG0003@2|Bacteria,2GJYN@201174|Actinobacteria,4ERU9@85013|Frankiales	201174|Actinobacteria	D	PFAM Anion-transporting ATPase	-	-	-	-	-	-	-	-	-	-	-	-	ArsA_ATPase
HKD2_k127_3128875_2	222534.KB893724_gene446	1.01e-35	136.0	2CC1Y@1|root,32TCV@2|Bacteria,2IQEP@201174|Actinobacteria,4ET77@85013|Frankiales	201174|Actinobacteria	K	Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA	whiB4	GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0008152,GO:0015036,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0030312,GO:0043254,GO:0044087,GO:0044464,GO:0047134,GO:0048037,GO:0050789,GO:0050794,GO:0051128,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0065007,GO:0071944,GO:0090034,GO:0097159,GO:1901363	-	ko:K18955	-	-	-	-	ko00000,ko03000	-	-	-	Whib
HKD2_k127_3130910_4	1246448.ANAZ01000052_gene1990	1.375e-16	89.0	COG2161@1|root,COG2161@2|Bacteria,2GV08@201174|Actinobacteria,4EQGZ@85012|Streptosporangiales	201174|Actinobacteria	D	Antitoxin Phd_YefM, type II toxin-antitoxin system	relB	GO:0003674,GO:0005488,GO:0005515,GO:0008150,GO:0040008,GO:0045927,GO:0048518,GO:0050789,GO:0065007,GO:0097351	-	ko:K19159	-	-	-	-	ko00000,ko02048	-	-	-	PhdYeFM_antitox
HKD2_k127_3130910_0	298655.KI912266_gene2838	0.0	1164.0	COG0474@1|root,COG0474@2|Bacteria,2GJJC@201174|Actinobacteria,4ERMH@85013|Frankiales	201174|Actinobacteria	P	Cation transporter/ATPase, N-terminus	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
HKD2_k127_3130910_2	1120950.KB892760_gene5744	6.829e-120	412.0	COG0153@1|root,COG0153@2|Bacteria,2GJXI@201174|Actinobacteria,4DQ3A@85009|Propionibacteriales	201174|Actinobacteria	G	Belongs to the GHMP kinase family	galK	-	2.7.1.6	ko:K00849	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00554,M00632	R01092	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	GHMP_kinases_C,GHMP_kinases_N,GalKase_gal_bdg
HKD2_k127_3130910_1	390989.JOEG01000025_gene104	1.2e-160	513.0	COG1085@1|root,COG1085@2|Bacteria,2I2DM@201174|Actinobacteria,4D8TH@85008|Micromonosporales	201174|Actinobacteria	G	Galactose-1-phosphate uridylyltransferase	galT	-	2.7.7.12	ko:K00965	ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917	M00362,M00554,M00632	R00955	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	GalP_UDP_tr_C,GalP_UDP_transf
HKD2_k127_3130910_5	1229780.BN381_130135	6.359e-07	56.0	COG2002@1|root,COG2002@2|Bacteria,2GUD2@201174|Actinobacteria	201174|Actinobacteria	K	toxin-antitoxin pair type II binding	-	-	-	-	-	-	-	-	-	-	-	-	MazE_antitoxin
HKD2_k127_3130910_3	1907.SGLAU_33060	2.329e-18	89.0	2EF5E@1|root,31KM2@2|Bacteria,2IKZ8@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3136984_3	1122611.KB903955_gene5582	4.137e-121	412.0	COG1181@1|root,COG1181@2|Bacteria,2GRWM@201174|Actinobacteria,4EFUD@85012|Streptosporangiales	201174|Actinobacteria	M	Belongs to the D-alanine--D-alanine ligase family	ddl	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C,Dala_Dala_lig_N
HKD2_k127_3136984_0	1449976.KALB_8832	4.645e-188	596.0	COG1167@1|root,COG1167@2|Bacteria,2GITW@201174|Actinobacteria,4E0UW@85010|Pseudonocardiales	201174|Actinobacteria	EK	PFAM Aminotransferase class I and II	avtA	-	-	ko:K05825	ko00300,ko01100,ko01130,ko01210,map00300,map01100,map01130,map01210	-	R01939	RC00006	ko00000,ko00001,ko01000	-	-	-	Aminotran_1_2
HKD2_k127_3136984_4	656024.FsymDg_4544	9.359e-112	366.0	COG3153@1|root,COG3153@2|Bacteria,2GNNB@201174|Actinobacteria,4ERW8@85013|Frankiales	201174|Actinobacteria	S	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HKD2_k127_3136984_1	656024.FsymDg_4543	1.953e-163	528.0	COG0860@1|root,COG3409@1|root,COG0860@2|Bacteria,COG3409@2|Bacteria,2GPA9@201174|Actinobacteria,4ERBQ@85013|Frankiales	201174|Actinobacteria	M	Cell wall hydrolase autolysin	cwlM	GO:0005575,GO:0005623,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	Amidase_3,PG_binding_1
HKD2_k127_3136984_6	298654.FraEuI1c_7194	5.159e-52	186.0	COG3118@1|root,COG3118@2|Bacteria,2IQ9T@201174|Actinobacteria,4ET42@85013|Frankiales	201174|Actinobacteria	O	Belongs to the thioredoxin family	trxA	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
HKD2_k127_3136984_2	106370.Francci3_4536	1.044e-156	512.0	COG0492@1|root,COG0492@2|Bacteria,2GKD2@201174|Actinobacteria,4ERUM@85013|Frankiales	201174|Actinobacteria	C	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family	trxB	GO:0000166,GO:0001666,GO:0003674,GO:0003824,GO:0004791,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0008150,GO:0008152,GO:0009628,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0019725,GO:0036094,GO:0036293,GO:0040007,GO:0042221,GO:0042592,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0048037,GO:0050660,GO:0050661,GO:0050662,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070402,GO:0070482,GO:0070887,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901265,GO:1901363,GO:1990748	1.8.1.9	ko:K00384,ko:K03671	ko00450,ko04621,ko05418,map00450,map04621,map05418	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000,ko03110	-	-	iNJ661.Rv3913	Pyr_redox_2
HKD2_k127_3136984_8	656024.FsymDg_4540	8.641e-24	117.0	COG5662@1|root,COG5662@2|Bacteria	2|Bacteria	K	AntiSigma factor	-	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
HKD2_k127_3136984_5	446462.Amir_7084	1.832e-65	235.0	COG1595@1|root,COG1595@2|Bacteria,2GJMX@201174|Actinobacteria,4DXS2@85010|Pseudonocardiales	201174|Actinobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	sigM	GO:0001101,GO:0005575,GO:0005623,GO:0005886,GO:0006355,GO:0008150,GO:0009410,GO:0009415,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0010035,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016020,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0042221,GO:0044464,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:1901700,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD2_k127_3136984_7	222534.KB893717_gene2039	1.101e-34	140.0	COG0515@1|root,COG0515@2|Bacteria,2GM4A@201174|Actinobacteria,4ET0S@85013|Frankiales	201174|Actinobacteria	KLT	serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
HKD2_k127_3144608_0	1146883.BLASA_2233	4.513e-106	350.0	COG3842@1|root,COG3842@2|Bacteria,2GJCM@201174|Actinobacteria,4ES4E@85013|Frankiales	201174|Actinobacteria	P	Belongs to the ABC transporter superfamily	ugpC	-	-	ko:K10112	ko02010,map02010	M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1	-	-	ABC_tran,TOBE,TOBE_2
HKD2_k127_3144608_3	1122182.KB903835_gene4683	4.636e-33	131.0	COG3842@1|root,COG3842@2|Bacteria,2GJCM@201174|Actinobacteria,4D9U3@85008|Micromonosporales	201174|Actinobacteria	E	Belongs to the ABC transporter superfamily	-	-	-	ko:K10112	ko02010,map02010	M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1	-	-	ABC_tran,TOBE_2
HKD2_k127_3144608_2	56110.Oscil6304_0344	1.018e-81	294.0	COG0395@1|root,COG0395@2|Bacteria,1G0JV@1117|Cyanobacteria,1H7WS@1150|Oscillatoriales	2|Bacteria	G	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
HKD2_k127_3144608_1	1173020.Cha6605_0365	4.315e-87	303.0	COG1175@1|root,COG1175@2|Bacteria,1GCY9@1117|Cyanobacteria	1117|Cyanobacteria	U	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
HKD2_k127_3160015_2	298655.KI912266_gene2067	9.884e-76	256.0	COG0604@1|root,COG0604@2|Bacteria,2GMHR@201174|Actinobacteria,4ES0D@85013|Frankiales	201174|Actinobacteria	C	PFAM Alcohol dehydrogenase, zinc-binding	adh3	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N,ADH_zinc_N_2
HKD2_k127_3160015_1	1110697.NCAST_24_00070	2.06e-84	293.0	COG1819@1|root,COG1819@2|Bacteria,2I8EN@201174|Actinobacteria,4FWJ2@85025|Nocardiaceae	201174|Actinobacteria	CG	Glycosyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tran_28_C,UDPGT
HKD2_k127_3160015_4	526225.Gobs_1457	4.963e-10	67.0	COG3744@1|root,COG3744@2|Bacteria	2|Bacteria	S	ribonuclease activity	-	GO:0005575,GO:0005576,GO:0006417,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0017148,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:2000112,GO:2000113	-	-	-	-	-	-	-	-	-	-	PIN
HKD2_k127_3160015_3	500153.JOEK01000002_gene415	4.21e-24	102.0	2E460@1|root,32Z20@2|Bacteria,2GQGS@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3160015_0	656024.FsymDg_0989	0.0	1464.0	COG0508@1|root,COG0567@1|root,COG0508@2|Bacteria,COG0567@2|Bacteria,2GIU6@201174|Actinobacteria,4ES2Q@85013|Frankiales	201174|Actinobacteria	C	TIGRFAM 2-oxoglutarate dehydrogenase, E1	kgd	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006103,GO:0008150,GO:0008152,GO:0008683,GO:0009055,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016740,GO:0016744,GO:0016829,GO:0016830,GO:0016831,GO:0016999,GO:0017144,GO:0019752,GO:0022900,GO:0030312,GO:0032991,GO:0040007,GO:0043167,GO:0043169,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045254,GO:0045333,GO:0046872,GO:0050439,GO:0051186,GO:0055114,GO:0071704,GO:0071944,GO:0072350,GO:1902494,GO:1990204,GO:1990234	1.2.4.2,4.1.1.71	ko:K00164,ko:K01616	ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R00621,R01933,R01940,R03316,R08549	RC00004,RC00027,RC00627,RC02743,RC02833,RC02883	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv1248c	2-oxoacid_dh,2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr
HKD2_k127_3198238_1	996637.SGM_6466	1.466e-46	171.0	COG5615@1|root,COG5615@2|Bacteria,2IHAA@201174|Actinobacteria	201174|Actinobacteria	S	integral membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3198238_0	882083.SacmaDRAFT_2605	0.0	1334.0	COG5013@1|root,COG5013@2|Bacteria,2GKZU@201174|Actinobacteria,4DZ13@85010|Pseudonocardiales	201174|Actinobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	narZ	-	1.7.5.1	ko:K00370	ko00910,ko01120,ko02020,map00910,map01120,map02020	M00529,M00530,M00804	R00798,R01106,R09497	RC02812	ko00000,ko00001,ko00002,ko01000	5.A.3.1	-	-	Molybdopterin,Molydop_binding
HKD2_k127_3217246_0	929712.KI912613_gene3764	1.671e-153	494.0	COG0365@1|root,COG0365@2|Bacteria,2GJSQ@201174|Actinobacteria,4CRGY@84995|Rubrobacteria	84995|Rubrobacteria	I	AMP-binding enzyme C-terminal domain	-	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
HKD2_k127_3217246_4	479433.Caci_1394	2.052e-60	218.0	COG0586@1|root,COG0586@2|Bacteria,2GKKC@201174|Actinobacteria	201174|Actinobacteria	I	SNARE associated Golgi protein	-	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	SNARE_assoc
HKD2_k127_3217246_7	1907.SGLAU_29410	2.678e-44	171.0	COG0526@1|root,COG0526@2|Bacteria,2IKP1@201174|Actinobacteria	201174|Actinobacteria	CO	Belongs to the thioredoxin family	trxA	GO:0003674,GO:0003824,GO:0004791,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0016671,GO:0019725,GO:0033554,GO:0034599,GO:0042221,GO:0042592,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0047134,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748	1.8.1.9	ko:K00384,ko:K03671	ko00450,ko04621,ko05418,map00450,map04621,map05418	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000,ko03110	-	-	-	Thioredoxin
HKD2_k127_3217246_11	981369.JQMJ01000004_gene6405	6.392e-24	104.0	COG1937@1|root,COG1937@2|Bacteria,2IQ7U@201174|Actinobacteria,2NJCG@228398|Streptacidiphilus	201174|Actinobacteria	S	Metal-sensitive transcriptional repressor	-	-	-	-	-	-	-	-	-	-	-	-	Trns_repr_metal
HKD2_k127_3217246_1	1304865.JAGF01000001_gene828	5.156e-73	254.0	COG2120@1|root,COG2120@2|Bacteria,2IJ0C@201174|Actinobacteria	201174|Actinobacteria	S	GlcNAc-PI de-N-acetylase	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
HKD2_k127_3217246_5	1385521.N803_17340	1.313e-56	200.0	COG1487@1|root,COG1487@2|Bacteria,2IMGJ@201174|Actinobacteria	201174|Actinobacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	GO:0003674,GO:0003824,GO:0004518,GO:0004540,GO:0006139,GO:0006417,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0016070,GO:0016787,GO:0016788,GO:0017148,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360,GO:2000112,GO:2000113	-	-	-	-	-	-	-	-	-	-	PIN
HKD2_k127_3217246_3	313589.JNB_10739	3.606e-69	246.0	COG0730@1|root,COG0730@2|Bacteria,2I5VT@201174|Actinobacteria,4FF73@85021|Intrasporangiaceae	201174|Actinobacteria	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
HKD2_k127_3217246_10	525904.Tter_2726	2.095e-33	136.0	2EBEI@1|root,335F5@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3217246_12	1121946.AUAX01000002_gene289	1.118e-12	78.0	COG0491@1|root,COG0607@1|root,COG0491@2|Bacteria,COG0607@2|Bacteria,2GN50@201174|Actinobacteria,4D9SE@85008|Micromonosporales	201174|Actinobacteria	P	Rhodanese domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B,Rhodanese
HKD2_k127_3217246_6	1906.SFRA_18140	2.805e-48	178.0	COG3439@1|root,COG3439@2|Bacteria,2IKVF@201174|Actinobacteria	201174|Actinobacteria	S	Domain of unknown function DUF302	-	-	-	-	-	-	-	-	-	-	-	-	DUF302
HKD2_k127_3217246_8	1206731.BAGB01000037_gene9238	1.658e-35	153.0	COG0500@1|root,COG2226@2|Bacteria,2H9G5@201174|Actinobacteria,4G6QX@85025|Nocardiaceae	201174|Actinobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
HKD2_k127_3217246_2	44060.JODL01000024_gene308	2.286e-71	246.0	COG0500@1|root,COG2226@2|Bacteria,2I36Q@201174|Actinobacteria	201174|Actinobacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
HKD2_k127_3217246_9	1386089.N865_03330	9.573e-35	136.0	COG1765@1|root,COG1765@2|Bacteria,2IFY4@201174|Actinobacteria	201174|Actinobacteria	O	PFAM OsmC family protein	-	-	-	-	-	-	-	-	-	-	-	-	OsmC
HKD2_k127_3218269_4	656024.FsymDg_4501	1.384e-24	105.0	COG3572@1|root,COG3572@2|Bacteria,2GJPI@201174|Actinobacteria,4ESKR@85013|Frankiales	201174|Actinobacteria	H	Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC). This compound is used as substrate for the biosynthesis of the low-molecular thiol compound ergothioneine	egtA	GO:0003674,GO:0003824,GO:0004357,GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0016874,GO:0016879,GO:0016881,GO:0044464,GO:0071944	6.3.2.2	ko:K01919	ko00270,ko00480,ko01100,map00270,map00480,map01100	M00118	R00894,R10993	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv3704c	GCS2
HKD2_k127_3218269_0	479432.Sros_0331	1.753e-215	680.0	COG1262@1|root,COG1262@2|Bacteria,2GK9Q@201174|Actinobacteria,4EFSE@85012|Streptosporangiales	201174|Actinobacteria	S	Catalyzes the oxidative sulfurization of hercynine (N- alpha,N-alpha,N-alpha-trimethyl-L-histidine) into hercynyl-gamma- L-glutamyl-L-cysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine	egtB	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0006082,GO:0006520,GO:0006547,GO:0006548,GO:0006575,GO:0006577,GO:0006578,GO:0006725,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009987,GO:0016053,GO:0016054,GO:0016491,GO:0019439,GO:0019752,GO:0034641,GO:0042398,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044272,GO:0044281,GO:0044282,GO:0044283,GO:0046394,GO:0046395,GO:0046483,GO:0046700,GO:0046872,GO:0046914,GO:0052698,GO:0052699,GO:0052701,GO:0052703,GO:0052704,GO:0052708,GO:0052803,GO:0052805,GO:0055114,GO:0071704,GO:0097164,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606	1.14.99.50	ko:K18912	ko00340,map00340	-	R11013	RC03323,RC03324	ko00000,ko00001,ko01000	-	-	-	DinB_2,FGE-sulfatase
HKD2_k127_3218269_2	1122611.KB903985_gene3688	8.812e-83	283.0	COG0121@1|root,COG0121@2|Bacteria,2GXCD@201174|Actinobacteria,4EJUR@85012|Streptosporangiales	201174|Actinobacteria	S	Catalyzes the hydrolysis of the gamma-glutamyl amide bond of hercynyl-gamma-L-glutamyl-L-cysteine sulfoxide to produce hercynylcysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine	egtC	GO:0000096,GO:0000097,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006518,GO:0006520,GO:0006547,GO:0006548,GO:0006575,GO:0006577,GO:0006578,GO:0006725,GO:0006749,GO:0006751,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009987,GO:0016020,GO:0016053,GO:0016054,GO:0019439,GO:0019752,GO:0032991,GO:0034641,GO:0042219,GO:0042398,GO:0043171,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044272,GO:0044273,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046395,GO:0046483,GO:0046700,GO:0051186,GO:0051187,GO:0052698,GO:0052699,GO:0052701,GO:0052703,GO:0052704,GO:0052708,GO:0052803,GO:0052805,GO:0061672,GO:0071704,GO:0071944,GO:0097164,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1902494,GO:1905368	3.5.1.118	ko:K07008	ko00340,map00340	-	R11021	RC00064,RC00090	ko00000,ko00001,ko01000	-	-	-	GATase_6
HKD2_k127_3218269_1	526225.Gobs_0202	3.643e-136	443.0	COG4301@1|root,COG4301@2|Bacteria,2GJAX@201174|Actinobacteria,4ERND@85013|Frankiales	201174|Actinobacteria	S	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine	egtD	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006464,GO:0006479,GO:0006520,GO:0006547,GO:0006548,GO:0006575,GO:0006577,GO:0006578,GO:0006725,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008213,GO:0008276,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009987,GO:0016020,GO:0016053,GO:0016054,GO:0016740,GO:0016741,GO:0019439,GO:0019538,GO:0019752,GO:0032259,GO:0034641,GO:0036211,GO:0042398,GO:0043170,GO:0043412,GO:0043414,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044267,GO:0044270,GO:0044271,GO:0044272,GO:0044281,GO:0044282,GO:0044283,GO:0044464,GO:0046394,GO:0046395,GO:0046483,GO:0046700,GO:0052698,GO:0052699,GO:0052701,GO:0052703,GO:0052704,GO:0052707,GO:0052708,GO:0052709,GO:0052803,GO:0052805,GO:0071704,GO:0071944,GO:0097164,GO:0140096,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607	2.1.1.44	ko:K18911	ko00340,map00340	-	R01169	RC00003,RC02308	ko00000,ko00001,ko01000	-	-	-	Methyltransf_33
HKD2_k127_3218269_3	351607.Acel_0234	1.739e-41	158.0	COG1011@1|root,COG1011@2|Bacteria	2|Bacteria	S	phosphatase activity	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2,Hydrolase,Hydrolase_like
HKD2_k127_3219793_7	656024.FsymDg_3737	3.563e-32	137.0	COG1396@1|root,COG1396@2|Bacteria,2I60I@201174|Actinobacteria	201174|Actinobacteria	K	sequence-specific DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3219793_8	134676.ACPL_3800	2.755e-29	129.0	COG1813@1|root,COG5606@1|root,COG1813@2|Bacteria,COG5606@2|Bacteria,2I39C@201174|Actinobacteria,4D8IT@85008|Micromonosporales	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_31
HKD2_k127_3219793_6	134676.ACPL_3800	2.23e-36	144.0	COG1813@1|root,COG5606@1|root,COG1813@2|Bacteria,COG5606@2|Bacteria,2I39C@201174|Actinobacteria,4D8IT@85008|Micromonosporales	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_31
HKD2_k127_3219793_3	471852.Tcur_2077	1.152e-63	228.0	COG0452@1|root,COG0452@2|Bacteria,2GP82@201174|Actinobacteria,4EIZD@85012|Streptosporangiales	201174|Actinobacteria	H	Flavoprotein	-	-	-	-	-	-	-	-	-	-	-	-	Flavoprotein
HKD2_k127_3219793_4	1157640.AQWO01000018_gene5413	3.569e-51	187.0	COG3285@1|root,COG3285@2|Bacteria,2GM0A@201174|Actinobacteria	201174|Actinobacteria	L	DNA primase, small subunit	ligD	-	-	-	-	-	-	-	-	-	-	-	DNA_primase_S
HKD2_k127_3219793_9	222534.KB893725_gene293	6.585e-20	96.0	COG3285@1|root,COG3285@2|Bacteria	2|Bacteria	L	DNA ligase (ATP) activity	-	-	-	-	-	-	-	-	-	-	-	-	DNA_primase_S
HKD2_k127_3219793_10	1229780.BN381_130135	2.644e-14	76.0	COG2002@1|root,COG2002@2|Bacteria,2GUD2@201174|Actinobacteria	201174|Actinobacteria	K	toxin-antitoxin pair type II binding	-	-	-	-	-	-	-	-	-	-	-	-	MazE_antitoxin
HKD2_k127_3219793_0	298653.Franean1_5172	1.441e-202	643.0	COG1086@1|root,COG2148@1|root,COG1086@2|Bacteria,COG2148@2|Bacteria,2GK0M@201174|Actinobacteria,4ES81@85013|Frankiales	201174|Actinobacteria	M	PFAM sugar transferase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_transf,CoA_binding_3
HKD2_k127_3219793_2	656024.FsymDg_1842	1.747e-95	321.0	COG1218@1|root,COG1218@2|Bacteria,2GMW7@201174|Actinobacteria,4ETX9@85013|Frankiales	201174|Actinobacteria	P	PFAM Inositol monophosphatase	cysQ_1	-	3.1.3.7	ko:K01082	ko00920,ko01100,ko01120,ko01130,map00920,map01100,map01120,map01130	-	R00188,R00508	RC00078	ko00000,ko00001,ko01000,ko03016	-	-	-	Inositol_P
HKD2_k127_3219793_1	710111.FraQA3DRAFT_0963	4.183e-98	344.0	COG0438@1|root,COG0438@2|Bacteria,2I8FJ@201174|Actinobacteria	201174|Actinobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
HKD2_k127_3219793_5	65497.JODV01000008_gene268	4.186e-41	168.0	COG0859@1|root,COG0859@2|Bacteria,2IFJI@201174|Actinobacteria,4E39B@85010|Pseudonocardiales	201174|Actinobacteria	M	Glycosyltransferase family 9 (heptosyltransferase)	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_9
HKD2_k127_3243208_1	298655.KI912266_gene2635	2.349e-47	176.0	COG0791@1|root,COG0791@2|Bacteria,2IFNI@201174|Actinobacteria,4EWEY@85013|Frankiales	201174|Actinobacteria	M	pfam nlp p60	-	-	-	-	-	-	-	-	-	-	-	-	NLPC_P60
HKD2_k127_3243208_4	1206735.BAGG01000093_gene4127	1.14e-25	119.0	COG2508@1|root,COG2508@2|Bacteria,2I2NJ@201174|Actinobacteria,4FY4K@85025|Nocardiaceae	201174|Actinobacteria	QT	PucR C-terminal helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_30
HKD2_k127_3243208_3	405948.SACE_5329	2.797e-27	127.0	COG2508@1|root,COG2508@2|Bacteria,2I2NJ@201174|Actinobacteria,4E170@85010|Pseudonocardiales	201174|Actinobacteria	QT	PucR C-terminal helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_30
HKD2_k127_3243208_2	390989.JOEG01000011_gene219	5.817e-46	189.0	COG2197@1|root,COG2197@2|Bacteria,2IFSK@201174|Actinobacteria,4DJ92@85008|Micromonosporales	201174|Actinobacteria	KT	helix_turn_helix, Lux Regulon	uvrY	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HKD2_k127_3243208_0	208439.AJAP_33980	1.198e-51	202.0	COG4585@1|root,COG4585@2|Bacteria,2I8JH@201174|Actinobacteria,4EA3X@85010|Pseudonocardiales	201174|Actinobacteria	T	Histidine kinase-like ATPases	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HATPase_c_2
HKD2_k127_3243208_5	882083.SacmaDRAFT_2973	3.734e-08	62.0	2E5BU@1|root,3303V@2|Bacteria,2IFCH@201174|Actinobacteria,4EC7H@85010|Pseudonocardiales	201174|Actinobacteria	-	-	-	-	-	ko:K18481	-	M00670	-	-	ko00000,ko00002,ko02000	3.A.1.27.4,3.A.1.27.5	-	-	-
HKD2_k127_3313_0	365528.KB891209_gene2194	1.088e-127	420.0	COG0631@1|root,COG0631@2|Bacteria,2GJ3M@201174|Actinobacteria,4ERJW@85013|Frankiales	201174|Actinobacteria	T	protein phosphatase 2C domain protein	pstP	GO:0000287,GO:0001932,GO:0001933,GO:0003674,GO:0003824,GO:0004647,GO:0004721,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006469,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009892,GO:0009987,GO:0010563,GO:0010605,GO:0016020,GO:0016021,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019220,GO:0019222,GO:0019538,GO:0030145,GO:0030312,GO:0031224,GO:0031226,GO:0031323,GO:0031324,GO:0031399,GO:0031400,GO:0032268,GO:0032269,GO:0033673,GO:0036211,GO:0042325,GO:0042326,GO:0042578,GO:0043085,GO:0043086,GO:0043167,GO:0043169,GO:0043170,GO:0043392,GO:0043412,GO:0043549,GO:0044092,GO:0044093,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0045859,GO:0045936,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0051098,GO:0051100,GO:0051101,GO:0051171,GO:0051172,GO:0051174,GO:0051246,GO:0051248,GO:0051338,GO:0051348,GO:0060255,GO:0065007,GO:0065009,GO:0071704,GO:0071944,GO:0080090,GO:0140096,GO:1901564	3.1.3.16	ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C,PP2C_2
HKD2_k127_3313_2	656024.FsymDg_0173	3.783e-56	220.0	COG1716@1|root,COG1716@2|Bacteria,2GKA7@201174|Actinobacteria,4ESTH@85013|Frankiales	201174|Actinobacteria	T	FHA domain containing protein	fhaB	GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006950,GO:0006979,GO:0008150,GO:0009987,GO:0016020,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044464,GO:0050896,GO:0051301,GO:0051704,GO:0071944	-	-	-	-	-	-	-	-	-	-	FHA,Yop-YscD_cpl
HKD2_k127_3313_1	710111.FraQA3DRAFT_4996	4.249e-92	313.0	COG1716@1|root,COG1716@2|Bacteria,2GNU2@201174|Actinobacteria,4ESRE@85013|Frankiales	201174|Actinobacteria	T	FHA domain containing protein	fhaA	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944,GO:0097159,GO:1901363	-	-	-	-	-	-	-	-	-	-	DUF3662,FHA,Yop-YscD_cpl
HKD2_k127_3313_5	557599.MKAN_13610	3.319e-12	78.0	2DMRS@1|root,32T8Q@2|Bacteria,2IQ7Q@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3313_4	1033730.CAHG01000016_gene450	2.073e-20	101.0	COG0730@1|root,COG0730@2|Bacteria	2|Bacteria	S	response to heat	-	-	-	ko:K06867,ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
HKD2_k127_3313_6	44060.JODL01000019_gene4725	1.409e-10	74.0	COG1366@1|root,COG1366@2|Bacteria,2IHP9@201174|Actinobacteria	201174|Actinobacteria	T	Belongs to the anti-sigma-factor antagonist family	-	-	-	ko:K04749	-	-	-	-	ko00000,ko03021	-	-	-	STAS,STAS_2
HKD2_k127_3313_3	1713.JOFV01000009_gene289	2.273e-39	151.0	COG2382@1|root,COG2382@2|Bacteria,2I2KB@201174|Actinobacteria	201174|Actinobacteria	P	Putative esterase	-	-	-	-	-	-	-	-	-	-	-	-	Esterase
HKD2_k127_3317462_1	656024.FsymDg_2572	0.0	1144.0	COG3280@1|root,COG3280@2|Bacteria,2GJTB@201174|Actinobacteria,4ES08@85013|Frankiales	201174|Actinobacteria	G	TIGRFAM Malto-oligosyltrehalose synthase	treY	GO:0000272,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005984,GO:0005991,GO:0005992,GO:0006073,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009251,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016052,GO:0016853,GO:0016866,GO:0030978,GO:0030980,GO:0034637,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044247,GO:0044248,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044275,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0047470,GO:0071704,GO:1901575,GO:1901576	5.4.99.15	ko:K06044	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R01824,R09995	-	ko00000,ko00001,ko00002,ko01000	-	GH13	-	Alpha-amylase
HKD2_k127_3317462_0	298653.Franean1_5164	0.0	1156.0	COG1523@1|root,COG3266@1|root,COG1523@2|Bacteria,COG3266@2|Bacteria,2GJ00@201174|Actinobacteria,4ES1X@85013|Frankiales	201174|Actinobacteria	G	Belongs to the glycosyl hydrolase 13 family	glgX	-	3.2.1.68	ko:K01214	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
HKD2_k127_3317462_2	710111.FraQA3DRAFT_2422	9.485e-87	308.0	COG1503@1|root,COG1503@2|Bacteria	2|Bacteria	J	translation release factor activity	-	GO:0001666,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0008150,GO:0009628,GO:0016020,GO:0030312,GO:0036293,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0070482,GO:0071944	-	ko:K03265	ko03015,map03015	-	-	-	ko00000,ko00001,ko03012,ko03019	-	-	-	DUF2795
HKD2_k127_3317462_3	710111.FraQA3DRAFT_2928	1.921e-75	263.0	299E4@1|root,2ZWGX@2|Bacteria,2GM90@201174|Actinobacteria,4ESSD@85013|Frankiales	201174|Actinobacteria	S	Protein of unknown function (DUF3145)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3145
HKD2_k127_3317462_4	298653.Franean1_5163	1.133e-46	174.0	2ATJW@1|root,3361K@2|Bacteria,2I80Y@201174|Actinobacteria	201174|Actinobacteria	S	Domain of unknown function (DUF4193)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4193
HKD2_k127_3362144_4	1048339.KB913029_gene5026	1.579e-94	324.0	COG0419@1|root,COG0419@2|Bacteria,2GKYR@201174|Actinobacteria,4ERV4@85013|Frankiales	201174|Actinobacteria	L	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	sbcC	-	-	ko:K03546	-	-	-	-	ko00000,ko03400	-	-	-	AAA_23,SbcCD_C
HKD2_k127_3362144_3	240015.ACP_3478	3.298e-116	384.0	COG1087@1|root,COG1087@2|Bacteria,3Y3FK@57723|Acidobacteria,2JI2G@204432|Acidobacteriia	204432|Acidobacteriia	M	Belongs to the NAD(P)-dependent epimerase dehydratase family	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
HKD2_k127_3362144_1	710111.FraQA3DRAFT_4144	5.233e-140	459.0	COG0683@1|root,COG0683@2|Bacteria	2|Bacteria	E	ABC-type branched-chain amino acid transport systems, periplasmic component	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
HKD2_k127_3362144_0	106370.Francci3_0381	1.169e-263	831.0	COG0559@1|root,COG4177@1|root,COG0559@2|Bacteria,COG4177@2|Bacteria,2GJHR@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997,ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HKD2_k127_3362144_2	656024.FsymDg_4201	3.408e-137	475.0	COG1129@1|root,COG1129@2|Bacteria,2I47N@201174|Actinobacteria	201174|Actinobacteria	P	Branched-chain amino acid ATP-binding cassette transporter	-	-	-	ko:K01995,ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C,BPD_transp_2
HKD2_k127_3362144_5	1003195.SCAT_4526	2.984e-69	265.0	COG2172@1|root,COG2203@1|root,COG2208@1|root,COG2172@2|Bacteria,COG2203@2|Bacteria,COG2208@2|Bacteria,2GKN8@201174|Actinobacteria	201174|Actinobacteria	T	SMART protein phosphatase 2C domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,GAF_3,HATPase_c_2,PAS,PAS_4,SpoIIE
HKD2_k127_3362144_7	1254432.SCE1572_35885	2.339e-07	64.0	COG0642@1|root,COG2203@1|root,COG5000@1|root,COG2203@2|Bacteria,COG2205@2|Bacteria,COG5000@2|Bacteria,1QV0D@1224|Proteobacteria,438B0@68525|delta/epsilon subdivisions,2X3KB@28221|Deltaproteobacteria,2YWEE@29|Myxococcales	28221|Deltaproteobacteria	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS_4,RsbRD_N
HKD2_k127_3362144_6	709986.Deima_1435	7.845e-55	210.0	COG4251@1|root,COG4251@2|Bacteria	2|Bacteria	T	photoreceptor activity	-	-	-	-	-	-	-	-	-	-	-	-	CHASE3,GAF_2,HATPase_c,HisKA,PAS,PAS_4,PAS_8,PAS_9,Response_reg
HKD2_k127_3401173_3	1229205.BUPH_08527	2.976e-05	46.0	COG5659@1|root,COG5659@2|Bacteria,1MWAV@1224|Proteobacteria,2W56T@28216|Betaproteobacteria,1KIBA@119060|Burkholderiaceae	28216|Betaproteobacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5
HKD2_k127_3401173_0	469383.Cwoe_3286	6.45e-151	486.0	COG0667@1|root,COG0667@2|Bacteria,2GJ4R@201174|Actinobacteria,4CPGH@84995|Rubrobacteria	84995|Rubrobacteria	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
HKD2_k127_3401173_1	43354.JOIJ01000003_gene4075	1.194e-105	351.0	COG1024@1|root,COG1024@2|Bacteria,2HHR6@201174|Actinobacteria,4DXU9@85010|Pseudonocardiales	201174|Actinobacteria	I	enoyl-CoA hydratase	Echdc	-	-	-	-	-	-	-	-	-	-	-	ECH_1
HKD2_k127_3401173_2	83332.Rv0582	1.756e-05	47.0	COG2402@1|root,COG2402@2|Bacteria,2HZHQ@201174|Actinobacteria,23BTY@1762|Mycobacteriaceae	201174|Actinobacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	GO:0008150,GO:0040008,GO:0045926,GO:0048519,GO:0050789,GO:0065007	-	ko:K07065	-	-	-	-	ko00000	-	-	-	PIN
HKD2_k127_3405282_21	1123024.AUII01000012_gene4221	1.932e-44	166.0	COG2513@1|root,COG2513@2|Bacteria,2GMQ4@201174|Actinobacteria,4E188@85010|Pseudonocardiales	201174|Actinobacteria	G	Phosphoenolpyruvate phosphomutase	-	-	-	-	-	-	-	-	-	-	-	-	PEP_mutase
HKD2_k127_3405282_29	106370.Francci3_0093	5.888e-11	72.0	COG3255@1|root,COG3255@2|Bacteria,2IQBF@201174|Actinobacteria,4ETAU@85013|Frankiales	201174|Actinobacteria	I	Sterol carrier protein	-	-	-	-	-	-	-	-	-	-	-	-	MDMPI_C,MDMPI_N
HKD2_k127_3405282_5	196490.AUEZ01000013_gene4728	6.074e-151	490.0	COG0277@1|root,COG0277@2|Bacteria,1MUPW@1224|Proteobacteria,2TUNK@28211|Alphaproteobacteria,3JSHP@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Berberine and berberine like	-	-	-	-	-	-	-	-	-	-	-	-	BBE,FAD_binding_4
HKD2_k127_3405282_20	1173023.KE650771_gene4387	3.049e-45	172.0	COG1309@1|root,COG1309@2|Bacteria,1G85G@1117|Cyanobacteria	1117|Cyanobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_13,TetR_N
HKD2_k127_3405282_12	1267533.KB906734_gene3829	3.26e-63	225.0	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HKD2_k127_3405282_15	298653.Franean1_2026	3.564e-54	209.0	COG1051@1|root,COG1051@2|Bacteria,2I2K5@201174|Actinobacteria	201174|Actinobacteria	F	Nudix hydrolase	-	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX
HKD2_k127_3405282_28	103733.JNYO01000012_gene2639	1.837e-13	75.0	COG1741@1|root,COG1741@2|Bacteria,2GIY9@201174|Actinobacteria,4DXA1@85010|Pseudonocardiales	201174|Actinobacteria	S	Pirin C-terminal cupin domain	yhhW_2	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin,Pirin_C
HKD2_k127_3405282_25	1121019.AUMN01000010_gene2014	1.323e-22	100.0	2BEA2@1|root,32812@2|Bacteria,2HDSC@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3405282_18	1121019.AUMN01000010_gene2013	7.798e-49	177.0	COG4113@1|root,COG4113@2|Bacteria,2GR4U@201174|Actinobacteria	201174|Actinobacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	-	-	-	-	-	-	-	-	-	PIN
HKD2_k127_3405282_4	298654.FraEuI1c_0825	4.224e-152	490.0	COG2421@1|root,COG2421@2|Bacteria,2HQSF@201174|Actinobacteria	201174|Actinobacteria	C	Acetamidase formamidase	-	-	-	-	-	-	-	-	-	-	-	-	FmdA_AmdA
HKD2_k127_3405282_17	1048339.KB913029_gene4292	1.298e-49	193.0	COG0730@1|root,COG0730@2|Bacteria,2GJCC@201174|Actinobacteria,4ESMQ@85013|Frankiales	201174|Actinobacteria	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
HKD2_k127_3405282_22	365528.KB891102_gene4347	1.049e-42	168.0	COG5553@1|root,COG5553@2|Bacteria,2I2T6@201174|Actinobacteria	201174|Actinobacteria	S	PFAM cysteine dioxygenase type I	-	-	-	-	-	-	-	-	-	-	-	-	CDO_I
HKD2_k127_3405282_16	298654.FraEuI1c_3038	2.692e-52	190.0	COG0607@1|root,COG0607@2|Bacteria,2IKTC@201174|Actinobacteria,4ET2W@85013|Frankiales	201174|Actinobacteria	P	SMART Rhodanese domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
HKD2_k127_3405282_14	656024.FsymDg_2188	2e-55	205.0	COG2062@1|root,COG2062@2|Bacteria,2GJ0I@201174|Actinobacteria,4ETFS@85013|Frankiales	201174|Actinobacteria	T	PFAM Phosphoglycerate mutase	sixA	-	-	ko:K08296	-	-	-	-	ko00000,ko01000	-	-	-	His_Phos_1
HKD2_k127_3405282_7	103733.JNYO01000020_gene1878	1.773e-106	350.0	COG4191@1|root,COG4191@2|Bacteria,2GMRD@201174|Actinobacteria,4DXPK@85010|Pseudonocardiales	201174|Actinobacteria	T	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,cNMP_binding
HKD2_k127_3405282_11	1464048.JNZS01000001_gene58	1.206e-65	236.0	COG3852@1|root,COG3852@2|Bacteria,2I3H8@201174|Actinobacteria,4DMG8@85008|Micromonosporales	201174|Actinobacteria	T	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,cNMP_binding
HKD2_k127_3405282_3	222534.KB893694_gene103	1.275e-182	591.0	COG0492@1|root,COG3437@1|root,COG0492@2|Bacteria,COG3437@2|Bacteria,2GK62@201174|Actinobacteria,4ERPW@85013|Frankiales	201174|Actinobacteria	KOT	FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_3,Response_reg
HKD2_k127_3405282_19	390989.JOEG01000007_gene646	2.998e-46	179.0	COG0492@1|root,COG3437@1|root,COG0492@2|Bacteria,COG3437@2|Bacteria,2GK62@201174|Actinobacteria,4D9VG@85008|Micromonosporales	201174|Actinobacteria	OT	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_3,Response_reg
HKD2_k127_3405282_24	639030.JHVA01000001_gene1150	4.065e-37	143.0	COG5207@1|root,COG5207@2|Bacteria,3Y5BD@57723|Acidobacteria,2JJT0@204432|Acidobacteriia	204432|Acidobacteriia	O	Zn-finger in ubiquitin-hydrolases and other protein	-	-	-	-	-	-	-	-	-	-	-	-	zf-UBP
HKD2_k127_3405282_10	1120936.KB907209_gene1348	5.951e-67	244.0	COG0451@1|root,COG0451@2|Bacteria,2GP24@201174|Actinobacteria,4EIW0@85012|Streptosporangiales	201174|Actinobacteria	M	GDP-mannose 4,6 dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
HKD2_k127_3405282_6	2074.JNYD01000036_gene5373	1.246e-116	398.0	COG1226@1|root,COG1226@2|Bacteria,2GJS6@201174|Actinobacteria,4E8CA@85010|Pseudonocardiales	201174|Actinobacteria	P	Ion channel	-	-	-	-	-	-	-	-	-	-	-	-	Ion_trans_2,TrkA_C,TrkA_N
HKD2_k127_3405282_1	298653.Franean1_4987	4.669e-264	822.0	COG0380@1|root,COG0380@2|Bacteria,2GMX7@201174|Actinobacteria,4ETWW@85013|Frankiales	201174|Actinobacteria	G	PFAM Glycosyl transferase, family 20	-	-	2.4.1.15,2.4.1.347	ko:K00697	ko00500,ko01100,map00500,map01100	-	R02737	RC00005,RC00049,RC02748	ko00000,ko00001,ko01000,ko01003	-	GT20	-	Glyco_transf_20
HKD2_k127_3405282_0	656024.FsymDg_2183	4.43e-295	929.0	COG1674@1|root,COG1674@2|Bacteria,2GR9J@201174|Actinobacteria	201174|Actinobacteria	D	PFAM cell divisionFtsK SpoIIIE	-	-	-	-	-	-	-	-	-	-	-	-	FtsK_SpoIIIE
HKD2_k127_3405282_31	656024.FsymDg_2183	4.605e-07	59.0	COG1674@1|root,COG1674@2|Bacteria,2GR9J@201174|Actinobacteria	201174|Actinobacteria	D	PFAM cell divisionFtsK SpoIIIE	-	-	-	-	-	-	-	-	-	-	-	-	FtsK_SpoIIIE
HKD2_k127_3405282_13	298654.FraEuI1c_2951	4.787e-62	218.0	COG5083@1|root,COG5083@2|Bacteria,2IFC7@201174|Actinobacteria	201174|Actinobacteria	S	phosphatidylinositol transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	Acid_phosphat_B
HKD2_k127_3405282_2	298655.KI912266_gene2249	4.564e-261	842.0	COG2909@1|root,COG2909@2|Bacteria,2GJAR@201174|Actinobacteria,4EXE3@85013|Frankiales	201174|Actinobacteria	K	AAA ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GerE
HKD2_k127_3405282_9	1380346.JNIH01000027_gene5812	5.827e-77	278.0	COG0842@1|root,COG0842@2|Bacteria,2GKJF@201174|Actinobacteria	201174|Actinobacteria	V	transport, permease protein	-	-	-	ko:K01992,ko:K18233	ko02010,map02010	M00254,M00634	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	3.A.1,3.A.1.105.2	-	-	ABC2_membrane
HKD2_k127_3405282_8	298654.FraEuI1c_2949	1.319e-104	346.0	COG1131@1|root,COG1131@2|Bacteria,2GIY8@201174|Actinobacteria,4ES16@85013|Frankiales	201174|Actinobacteria	V	TIGRFAM daunorubicin resistance ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
HKD2_k127_3441288_8	35754.JNYJ01000046_gene3114	2.873e-32	141.0	COG1607@1|root,COG1607@2|Bacteria,2IKM2@201174|Actinobacteria,4DDMP@85008|Micromonosporales	201174|Actinobacteria	I	Thioesterase superfamily	-	-	4.3.1.14	ko:K18014	ko00310,map00310	-	R03030	RC00833	ko00000,ko00001,ko01000	-	-	-	4HBT
HKD2_k127_3441288_7	1048339.KB913029_gene4162	1.481e-102	371.0	COG2185@1|root,COG2185@2|Bacteria,2HF50@201174|Actinobacteria,4EUNA@85013|Frankiales	201174|Actinobacteria	I	Dimerisation domain of d-ornithine 4,5-aminomutase	kamE	-	5.4.3.3	ko:K18011	ko00310,map00310	-	R02852,R03275	RC00719	ko00000,ko00001,ko01000	-	-	-	B12-binding,OAM_dimer
HKD2_k127_3441288_0	561175.KB894096_gene671	8.283e-246	769.0	COG0274@1|root,COG0274@2|Bacteria,2GUM7@201174|Actinobacteria,4ENGT@85012|Streptosporangiales	201174|Actinobacteria	F	D-Lysine 5,6-aminomutase TIM-barrel domain of alpha subunit	-	-	5.4.3.3	ko:K01844	ko00310,map00310	-	R02852,R03275	RC00719	ko00000,ko00001,ko01000	-	-	-	Lys-AminoMut_A
HKD2_k127_3441288_4	1394178.AWOO02000044_gene4509	7.258e-153	495.0	COG1063@1|root,COG1063@2|Bacteria,2GK3U@201174|Actinobacteria,4EMFY@85012|Streptosporangiales	201174|Actinobacteria	E	Dehydrogenase	-	-	1.4.1.11	ko:K18012	ko00310,map00310	-	R03349	RC00888	ko00000,ko00001,ko01000	-	-	-	-
HKD2_k127_3441288_1	1394178.AWOO02000044_gene4508	9.494e-234	731.0	COG1509@1|root,COG1509@2|Bacteria,2GM2P@201174|Actinobacteria	201174|Actinobacteria	E	lysine 2,3-aminomutase	kamA	-	5.4.3.2	ko:K01843	ko00310,map00310	-	R00461	RC00303	ko00000,ko00001,ko01000	-	-	-	-
HKD2_k127_3441288_3	222534.KB893716_gene1841	1.484e-153	500.0	COG1653@1|root,COG1653@2|Bacteria,2GM4E@201174|Actinobacteria,4EUHM@85013|Frankiales	201174|Actinobacteria	G	PFAM extracellular solute-binding protein family 1	lpqY	GO:0006810,GO:0008150,GO:0008643,GO:0009405,GO:0015766,GO:0015771,GO:0015772,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044403,GO:0044419,GO:0051179,GO:0051234,GO:0051704,GO:0071702	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1,SBP_bac_8
HKD2_k127_3441288_5	33898.JRHJ01000069_gene7072	9.104e-144	462.0	COG1175@1|root,COG1175@2|Bacteria,2GM6N@201174|Actinobacteria	201174|Actinobacteria	G	PFAM binding-protein-dependent transport systems inner membrane component	sugA	GO:0008150,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044403,GO:0044419,GO:0051704	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	iNJ661.Rv1236	BPD_transp_1
HKD2_k127_3441288_6	298653.Franean1_4615	2.925e-128	426.0	COG0395@1|root,COG0395@2|Bacteria,2GKEE@201174|Actinobacteria,4ET1P@85013|Frankiales	201174|Actinobacteria	P	PFAM binding-protein-dependent transport systems inner membrane component	sugB	GO:0008150,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044403,GO:0044419,GO:0051704	-	ko:K02026,ko:K10119	ko02010,map02010	M00196,M00207	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.28	-	-	BPD_transp_1
HKD2_k127_3441288_2	222534.KB893716_gene1838	1.051e-180	572.0	COG3842@1|root,COG3842@2|Bacteria,2GJCM@201174|Actinobacteria,4ES4E@85013|Frankiales	201174|Actinobacteria	P	Belongs to the ABC transporter superfamily	sugC	GO:0006810,GO:0008150,GO:0008643,GO:0009405,GO:0015766,GO:0015771,GO:0015772,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044403,GO:0044419,GO:0051179,GO:0051234,GO:0051704,GO:0071702	-	ko:K10112	ko02010,map02010	M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1	-	-	ABC_tran
HKD2_k127_3441288_9	2074.JNYD01000005_gene3152	8.892e-15	77.0	COG2129@1|root,COG2129@2|Bacteria,2ICBG@201174|Actinobacteria,4DYD7@85010|Pseudonocardiales	201174|Actinobacteria	S	Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos,Metallophos_2
HKD2_k127_3474193_1	994479.GL877879_gene5779	1.767e-121	410.0	COG0438@1|root,COG0438@2|Bacteria,2GNR8@201174|Actinobacteria,4DZIN@85010|Pseudonocardiales	201174|Actinobacteria	M	Glycosyl transferase 4-like	-	-	-	ko:K19424	-	-	-	-	ko00000,ko01000,ko01003	-	GT4	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
HKD2_k127_3474193_4	390989.JOEG01000001_gene5083	2.444e-67	243.0	COG0726@1|root,COG0726@2|Bacteria,2H6C7@201174|Actinobacteria	201174|Actinobacteria	G	polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
HKD2_k127_3474193_2	405948.SACE_3917	5.851e-91	335.0	COG2148@1|root,COG2148@2|Bacteria,2GK0M@201174|Actinobacteria,4DYEY@85010|Pseudonocardiales	201174|Actinobacteria	GM	Bacterial sugar transferase	wcaJ	-	-	-	-	-	-	-	-	-	-	-	Bac_transf,CoA_binding_3
HKD2_k127_3474193_3	1155714.KB891988_gene1390	5.062e-78	291.0	COG0438@1|root,COG0438@2|Bacteria,2GNIU@201174|Actinobacteria	201174|Actinobacteria	M	Glycosyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4
HKD2_k127_3474193_0	390989.JOEG01000001_gene5081	1.293e-131	437.0	COG2072@1|root,COG2072@2|Bacteria,2GJWE@201174|Actinobacteria,4DDK8@85008|Micromonosporales	201174|Actinobacteria	P	L-lysine 6-monooxygenase (NADPH-requiring)	-	-	-	-	-	-	-	-	-	-	-	-	K_oxygenase,Pyr_redox_3
HKD2_k127_3474193_5	390989.JOEG01000001_gene5080	2.215e-20	106.0	COG3919@1|root,COG3919@2|Bacteria,2HUNF@201174|Actinobacteria,4DKV4@85008|Micromonosporales	201174|Actinobacteria	S	ATP-grasp	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3502655_2	1463881.KL591022_gene1494	4.863e-25	104.0	COG0266@1|root,COG0266@2|Bacteria,2GKAM@201174|Actinobacteria	201174|Actinobacteria	L	Belongs to the FPG family	mutM1	-	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
HKD2_k127_3502655_0	1380356.JNIK01000006_gene1474	1.597e-134	442.0	COG1457@1|root,COG1457@2|Bacteria,2HTTH@201174|Actinobacteria,4EUC7@85013|Frankiales	201174|Actinobacteria	F	Permease for cytosine/purines, uracil, thiamine, allantoin	-	-	-	-	-	-	-	-	-	-	-	-	Transp_cyt_pur
HKD2_k127_3502655_4	1267533.KB906737_gene1550	4.596e-11	69.0	COG0251@1|root,COG0251@2|Bacteria,3Y540@57723|Acidobacteria,2JJVI@204432|Acidobacteriia	204432|Acidobacteriia	J	Endoribonuclease L-PSP	-	-	-	-	-	-	-	-	-	-	-	-	Ribonuc_L-PSP
HKD2_k127_3502655_3	1223543.GP2_033_00310	2.932e-23	113.0	COG0251@1|root,COG5637@1|root,COG0251@2|Bacteria,COG5637@2|Bacteria,2IN7X@201174|Actinobacteria,4GEKW@85026|Gordoniaceae	201174|Actinobacteria	J	polyketide cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
HKD2_k127_3502655_1	561175.KB894093_gene3898	3.485e-27	116.0	COG2172@1|root,COG2172@2|Bacteria,2I4J7@201174|Actinobacteria,4EKWD@85012|Streptosporangiales	201174|Actinobacteria	T	Histidine kinase-like ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c_2
HKD2_k127_351858_0	710111.FraQA3DRAFT_3662	5.745e-175	558.0	COG1721@1|root,COG1721@2|Bacteria,2GK9A@201174|Actinobacteria,4ETQM@85013|Frankiales	201174|Actinobacteria	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF11,DUF58
HKD2_k127_351858_1	710111.FraQA3DRAFT_3661	1.052e-158	533.0	COG0714@1|root,COG0714@2|Bacteria,2GK07@201174|Actinobacteria,4EUQ2@85013|Frankiales	201174|Actinobacteria	S	associated with various cellular activities	moxR2	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
HKD2_k127_351858_2	106370.Francci3_0760	8.696e-60	228.0	29B69@1|root,2ZY4N@2|Bacteria,2GKQW@201174|Actinobacteria,4EVKQ@85013|Frankiales	201174|Actinobacteria	S	Domain of unknown function (DUF4350)	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DUF4350
HKD2_k127_351858_3	656024.FsymDg_1102	3.812e-37	147.0	2CT9V@1|root,32SSX@2|Bacteria,2GKR6@201174|Actinobacteria,4EWHI@85013|Frankiales	201174|Actinobacteria	S	Domain of unknown function (DUF4129)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4129
HKD2_k127_3519819_9	298653.Franean1_6174	2.625e-22	99.0	COG1977@1|root,COG1977@2|Bacteria,2IQIT@201174|Actinobacteria,4ETG0@85013|Frankiales	201174|Actinobacteria	H	PFAM thiamineS protein	moaD2	-	-	ko:K03636	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
HKD2_k127_3519819_6	298654.FraEuI1c_6355	1.481e-127	416.0	COG0745@1|root,COG0745@2|Bacteria,2GJGU@201174|Actinobacteria,4ERJ7@85013|Frankiales	201174|Actinobacteria	K	Transcriptional regulator	glnR	-	-	-	-	-	-	-	-	-	-	-	Trans_reg_C
HKD2_k127_3519819_7	1122611.KB903970_gene2640	6.34e-97	348.0	COG0454@1|root,COG0456@2|Bacteria,2GM35@201174|Actinobacteria,4EHNC@85012|Streptosporangiales	201174|Actinobacteria	K	Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol	mshD	GO:0000302,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0006950,GO:0006979,GO:0008080,GO:0008150,GO:0008152,GO:0009058,GO:0009268,GO:0009628,GO:0009636,GO:0009987,GO:0010035,GO:0010125,GO:0010126,GO:0010447,GO:0016137,GO:0016138,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0033554,GO:0034599,GO:0034614,GO:0035447,GO:0035690,GO:0040007,GO:0042221,GO:0042493,GO:0042542,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044237,GO:0044249,GO:0044272,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0050896,GO:0051186,GO:0051188,GO:0051704,GO:0051716,GO:0070301,GO:0070887,GO:0071214,GO:0071236,GO:0071467,GO:0071468,GO:0071704,GO:0097237,GO:0104004,GO:1901135,GO:1901137,GO:1901576,GO:1901657,GO:1901659,GO:1901700,GO:1901701	2.3.1.189	ko:K15520	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_1
HKD2_k127_3519819_5	298653.Franean1_0352	3.444e-129	425.0	COG0226@1|root,COG0226@2|Bacteria,2GJXD@201174|Actinobacteria,4ERED@85013|Frankiales	201174|Actinobacteria	P	Part of the ABC transporter complex PstSACB involved in phosphate import	pstS	GO:0002682,GO:0002683,GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009607,GO:0009987,GO:0009991,GO:0015698,GO:0016020,GO:0016036,GO:0030312,GO:0031347,GO:0031348,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0035821,GO:0040007,GO:0042594,GO:0043207,GO:0044003,GO:0044110,GO:0044116,GO:0044117,GO:0044403,GO:0044413,GO:0044414,GO:0044419,GO:0044464,GO:0045088,GO:0045824,GO:0048519,GO:0048583,GO:0048585,GO:0050776,GO:0050777,GO:0050789,GO:0050896,GO:0051179,GO:0051234,GO:0051701,GO:0051704,GO:0051707,GO:0051716,GO:0051817,GO:0051832,GO:0051833,GO:0052031,GO:0052037,GO:0052167,GO:0052170,GO:0052173,GO:0052200,GO:0052255,GO:0052261,GO:0052306,GO:0052309,GO:0052552,GO:0052553,GO:0052561,GO:0052562,GO:0052564,GO:0052572,GO:0065007,GO:0071496,GO:0071944,GO:0075136,GO:0080134	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
HKD2_k127_3519819_4	656024.FsymDg_4099	3.131e-129	426.0	COG0573@1|root,COG0573@2|Bacteria,2GJDA@201174|Actinobacteria,4ESEM@85013|Frankiales	201174|Actinobacteria	P	probably responsible for the translocation of the substrate across the membrane	pstC	-	-	ko:K02037,ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
HKD2_k127_3519819_3	710111.FraQA3DRAFT_5190	1.795e-129	439.0	COG0581@1|root,COG0581@2|Bacteria,2I2F2@201174|Actinobacteria,4ERY1@85013|Frankiales	201174|Actinobacteria	P	PFAM binding-protein-dependent transport systems inner membrane component	pstA	GO:0008150,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044403,GO:0044419,GO:0051704	-	ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
HKD2_k127_3519819_0	656024.FsymDg_4097	4.802e-146	464.0	COG1117@1|root,COG1117@2|Bacteria,2GJQ3@201174|Actinobacteria,4ERC8@85013|Frankiales	201174|Actinobacteria	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	pstB	GO:0008150,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044403,GO:0044419,GO:0051704	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
HKD2_k127_3519819_10	1032480.MLP_05290	4.049e-17	83.0	290Z8@1|root,2ZNKZ@2|Bacteria,2HB42@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3519819_8	298653.Franean1_0351	5.56e-49	180.0	COG1611@1|root,COG1611@2|Bacteria,2IN1B@201174|Actinobacteria,4EW7R@85013|Frankiales	201174|Actinobacteria	S	Belongs to the LOG family	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
HKD2_k127_3519819_2	710111.FraQA3DRAFT_4324	1.604e-134	436.0	COG0667@1|root,COG0667@2|Bacteria,2H2ID@201174|Actinobacteria	201174|Actinobacteria	C	Aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
HKD2_k127_3519819_1	222534.KB893750_gene4281	5.329e-139	457.0	COG3025@1|root,COG5607@1|root,COG3025@2|Bacteria,COG5607@2|Bacteria,2GJZH@201174|Actinobacteria,4EU94@85013|Frankiales	201174|Actinobacteria	S	PFAM CHAD domain containing protein	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	CHAD,CYTH
HKD2_k127_3554483_0	106370.Francci3_1119	4.441e-99	332.0	COG5433@1|root,COG5433@2|Bacteria,2HYBN@201174|Actinobacteria,4EWGM@85013|Frankiales	201174|Actinobacteria	L	required for the transposition of insertion element IS2404	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_assoc
HKD2_k127_3554483_3	479432.Sros_7411	1.573e-11	67.0	COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,2ICGM@201174|Actinobacteria	201174|Actinobacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_29,HTH_32
HKD2_k127_3554483_1	2002.JOEQ01000071_gene6134	2.384e-63	229.0	COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,2ICGM@201174|Actinobacteria	201174|Actinobacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_29,HTH_32
HKD2_k127_3554483_2	479432.Sros_7411	3.129e-20	92.0	COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,2ICGM@201174|Actinobacteria	201174|Actinobacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_29,HTH_32
HKD2_k127_3602787_1	1380390.JIAT01000005_gene5144	2.542e-114	379.0	COG3173@1|root,COG3173@2|Bacteria,2GJT0@201174|Actinobacteria,4CSSU@84995|Rubrobacteria	84995|Rubrobacteria	S	Phosphotransferase enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	APH
HKD2_k127_3602787_2	215803.DB30_3887	1.223e-46	171.0	COG1764@1|root,COG1764@2|Bacteria,1RD1A@1224|Proteobacteria,4382H@68525|delta/epsilon subdivisions,2X3CJ@28221|Deltaproteobacteria,2YVEX@29|Myxococcales	28221|Deltaproteobacteria	O	Organic hydroperoxide resistance protein	ohr	-	-	-	-	-	-	-	-	-	-	-	OsmC
HKD2_k127_3602787_0	298654.FraEuI1c_4193	2.78e-162	516.0	COG1960@1|root,COG1960@2|Bacteria,2GKQI@201174|Actinobacteria,4ERGI@85013|Frankiales	201174|Actinobacteria	I	acyl-CoA dehydrogenase	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HKD2_k127_3647591_0	298654.FraEuI1c_2368	8.196e-95	316.0	COG0768@1|root,COG0768@2|Bacteria,2GKHH@201174|Actinobacteria,4ERN7@85013|Frankiales	201174|Actinobacteria	M	Penicillin-binding protein, dimerisation domain	ftsI	-	3.4.16.4	ko:K03587	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011,ko03036	-	-	-	PBP_dimer,Transpeptidase
HKD2_k127_3647591_1	298653.Franean1_5103	2.055e-83	296.0	COG0769@1|root,COG0769@2|Bacteria,2GIS2@201174|Actinobacteria,4ES9W@85013|Frankiales	201174|Actinobacteria	M	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan	murE	GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008765,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	6.3.2.13	ko:K01928	ko00300,ko00550,map00300,map00550	-	R02788	RC00064,RC00090	ko00000,ko00001,ko01000,ko01011	-	-	iNJ661.Rv2158c	Mur_ligase,Mur_ligase_C,Mur_ligase_M
HKD2_k127_372524_0	326424.FRAAL5056	8.203e-169	539.0	COG0463@1|root,COG0463@2|Bacteria,2I2GR@201174|Actinobacteria,4ESEF@85013|Frankiales	201174|Actinobacteria	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HKD2_k127_372524_3	365528.KB891252_gene5695	3.04e-50	199.0	COG0704@1|root,COG0704@2|Bacteria,2GKAD@201174|Actinobacteria,4ESDP@85013|Frankiales	201174|Actinobacteria	P	Plays a role in the regulation of phosphate uptake	phoU	-	-	ko:K02039	-	-	-	-	ko00000	-	-	-	PhoU
HKD2_k127_372524_4	469371.Tbis_1701	4.157e-21	95.0	2E60G@1|root,3207J@2|Bacteria,2I1FZ@201174|Actinobacteria,4ED39@85010|Pseudonocardiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_372524_1	656024.FsymDg_0588	3.631e-161	517.0	COG1064@1|root,COG1064@2|Bacteria,2GNVQ@201174|Actinobacteria,4ES74@85013|Frankiales	201174|Actinobacteria	C	PFAM Alcohol dehydrogenase	adhA	-	1.1.1.1	ko:K13953	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
HKD2_k127_372524_5	1122247.C731_0496	6.496e-10	64.0	COG0671@1|root,COG1597@1|root,COG0671@2|Bacteria,COG1597@2|Bacteria,2GM2U@201174|Actinobacteria,235UM@1762|Mycobacteriaceae	201174|Actinobacteria	I	diacylglycerol kinase, catalytic	bmrU	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	DAGK_cat,PAP2
HKD2_k127_372524_2	656024.FsymDg_2526	5.17e-86	290.0	28RNA@1|root,2ZE10@2|Bacteria,2HAK7@201174|Actinobacteria,4EWXI@85013|Frankiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3727770_10	710111.FraQA3DRAFT_0317	1.008e-99	331.0	COG0491@1|root,COG0491@2|Bacteria,2GKJA@201174|Actinobacteria,4ESD2@85013|Frankiales	201174|Actinobacteria	S	beta-lactamase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HKD2_k127_3727770_0	106370.Francci3_1631	0.0	1727.0	COG0178@1|root,COG0178@2|Bacteria,2GJUV@201174|Actinobacteria,4ERXD@85013|Frankiales	201174|Actinobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	GO:0000018,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009892,GO:0009987,GO:0010605,GO:0016020,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031324,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0045910,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0051716,GO:0060255,GO:0060542,GO:0060543,GO:0065007,GO:0071944,GO:0080090	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
HKD2_k127_3727770_12	526225.Gobs_1457	1.626e-21	99.0	COG3744@1|root,COG3744@2|Bacteria	2|Bacteria	S	ribonuclease activity	-	GO:0005575,GO:0005576,GO:0006417,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0017148,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:2000112,GO:2000113	-	-	-	-	-	-	-	-	-	-	PIN
HKD2_k127_3727770_1	365528.KB891219_gene1044	0.0	1026.0	COG0322@1|root,COG0322@2|Bacteria,2GIS4@201174|Actinobacteria,4ERT0@85013|Frankiales	201174|Actinobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009380,GO:0009987,GO:0016020,GO:0030312,GO:0032991,GO:0033554,GO:0040007,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:0071944,GO:1902494,GO:1905347,GO:1905348,GO:1990391	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N
HKD2_k127_3727770_7	365528.KB891219_gene1045	1.563e-146	479.0	COG1660@1|root,COG1660@2|Bacteria,2GMWB@201174|Actinobacteria,4EREI@85013|Frankiales	201174|Actinobacteria	S	Displays ATPase and GTPase activities	yvcJ	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K06958	-	-	-	-	ko00000,ko03019	-	-	-	ATP_bind_2
HKD2_k127_3727770_8	656024.FsymDg_2169	2.909e-130	425.0	COG0391@1|root,COG0391@2|Bacteria,2GJBW@201174|Actinobacteria,4ERHR@85013|Frankiales	201174|Actinobacteria	S	Required for morphogenesis under gluconeogenic growth conditions	-	-	-	-	-	-	-	-	-	-	-	-	UPF0052
HKD2_k127_3727770_4	106370.Francci3_1636	6.57e-170	541.0	COG1481@1|root,COG1481@2|Bacteria,2GJZU@201174|Actinobacteria,4ERBX@85013|Frankiales	201174|Actinobacteria	K	May be required for sporulation	whiA	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0043937,GO:0044464,GO:0050789,GO:0050793,GO:0065007,GO:0071944	-	ko:K09762	-	-	-	-	ko00000	-	-	-	HTH_WhiA,LAGLIDADG_WhiA,WhiA_N
HKD2_k127_3727770_3	298653.Franean1_2063	2.186e-170	558.0	COG0057@1|root,COG0057@2|Bacteria,2GJK4@201174|Actinobacteria,4ES5V@85013|Frankiales	201174|Actinobacteria	G	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family	gap	GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0036094,GO:0043891,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0097159,GO:1901265,GO:1901363	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Gp_dh_C,Gp_dh_N
HKD2_k127_3727770_5	1146883.BLASA_3237	1.119e-159	528.0	COG0126@1|root,COG0126@2|Bacteria,2GJC6@201174|Actinobacteria,4ES0I@85013|Frankiales	201174|Actinobacteria	F	Belongs to the phosphoglycerate kinase family	pgk	GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044424,GO:0044464,GO:0071944	2.7.2.3,5.3.1.1	ko:K00927,ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01015,R01512	RC00002,RC00043,RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
HKD2_k127_3727770_9	326424.FRAAL4586	1.706e-125	405.0	COG0149@1|root,COG0149@2|Bacteria,2GJXZ@201174|Actinobacteria	201174|Actinobacteria	G	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)	tpiA	GO:0003674,GO:0003824,GO:0004807,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0040007,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616	5.3.1.1	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01015	RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	TIM
HKD2_k127_3727770_6	1306174.JODP01000002_gene5862	2.493e-149	481.0	COG1173@1|root,COG1173@2|Bacteria,2GJ9E@201174|Actinobacteria	201174|Actinobacteria	EP	PFAM binding-protein-dependent transport systems inner membrane component	appC	-	-	ko:K02034,ko:K15582	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	BPD_transp_1,OppC_N
HKD2_k127_3727770_2	326424.FRAAL2821	4.702e-246	773.0	COG0747@1|root,COG0747@2|Bacteria,2GJXH@201174|Actinobacteria,4EUYS@85013|Frankiales	201174|Actinobacteria	E	Evidence 2b Function of strongly homologous gene	appA	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	Peptidase_C14,SBP_bac_5
HKD2_k127_3738301_2	266940.Krad_3500	3.195e-87	296.0	COG2116@1|root,COG2116@2|Bacteria,2GNU6@201174|Actinobacteria	201174|Actinobacteria	P	Formate nitrite	focA	-	-	-	-	-	-	-	-	-	-	-	Form_Nir_trans
HKD2_k127_3738301_0	33876.JNXY01000015_gene7455	2.289e-172	554.0	COG0467@1|root,COG0467@2|Bacteria,2I58C@201174|Actinobacteria,4DH7N@85008|Micromonosporales	201174|Actinobacteria	T	Circadian clock protein KaiC	-	-	-	ko:K08482	-	-	-	-	ko00000	-	-	-	ATPase
HKD2_k127_3738301_7	1089546.AQUI01000002_gene894	6.155e-24	111.0	COG0745@1|root,COG0745@2|Bacteria	1089546.AQUI01000002_gene894|-	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3738301_10	315749.Bcer98_1212	1.102e-09	68.0	COG0789@1|root,COG0789@2|Bacteria,1TQXC@1239|Firmicutes,4HCSG@91061|Bacilli,1ZD8Q@1386|Bacillus	91061|Bacilli	K	MerR family transcriptional regulator	ycgE	-	-	ko:K22491	-	-	-	-	ko00000,ko03000	-	-	-	B12-binding,B12-binding_2,MerR_1
HKD2_k127_3738301_5	1173020.Cha6605_0016	1.344e-29	136.0	COG2202@1|root,COG2203@1|root,COG3829@1|root,COG4251@1|root,COG2202@2|Bacteria,COG2203@2|Bacteria,COG3829@2|Bacteria,COG4251@2|Bacteria,1G0A1@1117|Cyanobacteria	2|Bacteria	T	PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	prpJ1	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008081,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009165,GO:0009166,GO:0009187,GO:0009190,GO:0009214,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042578,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0052621,GO:0055086,GO:0071111,GO:0071704,GO:0071944,GO:0090407,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576	3.1.3.3,4.6.1.1	ko:K01768,ko:K07315,ko:K11928	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000,ko02000,ko03021	2.A.21.2	-	-	GAF,GAF_2,HATPase_c_2,PAS,PAS_3,PAS_4,PAS_9,SpoIIE,sCache_3_2
HKD2_k127_3738301_4	66874.JOFS01000013_gene4576	9.111e-62	235.0	COG2172@1|root,COG2203@1|root,COG2208@1|root,COG2172@2|Bacteria,COG2203@2|Bacteria,COG2208@2|Bacteria,2GKN8@201174|Actinobacteria	201174|Actinobacteria	T	SMART protein phosphatase 2C domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,GAF_3,HATPase_c_2,PAS,PAS_4,SpoIIE
HKD2_k127_3738301_9	2002.JOEQ01000013_gene5452	4.524e-16	85.0	COG2217@1|root,COG2217@2|Bacteria,2GIRF@201174|Actinobacteria,4EN91@85012|Streptosporangiales	201174|Actinobacteria	P	E1-E2 ATPase	-	-	3.6.3.4,3.6.3.54	ko:K01533,ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,Hemerythrin,Hydrolase
HKD2_k127_3738301_6	465541.ATCJ01000005_gene3065	4.448e-24	118.0	2EIVK@1|root,33CKY@2|Bacteria,2GKAC@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3738301_1	665577.JH993789_gene7145	1.899e-107	357.0	COG2220@1|root,COG2220@2|Bacteria,2GMTR@201174|Actinobacteria	201174|Actinobacteria	E	Zn-dependent hydrolases of the beta-lactamase fold	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2,Lactamase_B_3
HKD2_k127_3738301_8	1132441.KI519455_gene3283	2.12e-16	93.0	COG0561@1|root,COG0561@2|Bacteria,2GMBX@201174|Actinobacteria	201174|Actinobacteria	S	phosphatase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3738301_3	590998.Celf_0214	3.152e-69	250.0	COG0503@1|root,COG1358@1|root,COG0503@2|Bacteria,COG1358@2|Bacteria,2GN88@201174|Actinobacteria	201174|Actinobacteria	FJ	PELOTA RNA binding domain	-	-	-	-	-	-	-	-	-	-	-	-	PELOTA_1,PRTase_1,PRTase_2,TRSP
HKD2_k127_3776790_1	469371.Tbis_1393	1.971e-148	487.0	COG0389@1|root,COG0389@2|Bacteria,2GKBI@201174|Actinobacteria,4DXRB@85010|Pseudonocardiales	201174|Actinobacteria	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	dinB	-	2.7.7.7	ko:K02346	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	HHH_5,IMS,IMS_C,IMS_HHH
HKD2_k127_3776790_2	656024.FsymDg_3125	6.299e-91	308.0	COG2227@1|root,COG2227@2|Bacteria,2GMAR@201174|Actinobacteria,4ESYG@85013|Frankiales	201174|Actinobacteria	H	Methyltransferase type 12	smtA	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_12,Methyltransf_23,Methyltransf_25
HKD2_k127_3776790_3	222534.KB893671_gene3270	1.641e-50	184.0	2CGM3@1|root,32S47@2|Bacteria,2GP7H@201174|Actinobacteria,4ET5Q@85013|Frankiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3776790_0	710111.FraQA3DRAFT_2876	2.636e-308	983.0	COG3629@1|root,COG3903@1|root,COG3629@2|Bacteria,COG3903@2|Bacteria,2GIRS@201174|Actinobacteria,4EU0Q@85013|Frankiales	201174|Actinobacteria	K	transcriptional activator domain	-	-	-	-	-	-	-	-	-	-	-	-	BTAD,NB-ARC,TPR_12,Trans_reg_C
HKD2_k127_378206_0	656024.FsymDg_3774	0.0	1055.0	COG0272@1|root,COG0272@2|Bacteria,2GJUY@201174|Actinobacteria,4ES5B@85013|Frankiales	201174|Actinobacteria	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	GO:0000287,GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016874,GO:0016886,GO:0030312,GO:0033554,GO:0034641,GO:0040007,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:0140097,GO:1901360	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2
HKD2_k127_378206_4	656024.FsymDg_3775	3.692e-130	426.0	COG0620@1|root,COG0620@2|Bacteria,2GMPS@201174|Actinobacteria,4ERS3@85013|Frankiales	201174|Actinobacteria	E	PFAM Methionine synthase, vitamin-B12 independent	-	-	-	-	-	-	-	-	-	-	-	-	Meth_synt_2
HKD2_k127_378206_14	1470591.BW41_03133	4.891e-06	55.0	COG4374@1|root,COG4374@2|Bacteria,1N7EF@1224|Proteobacteria,2UFJV@28211|Alphaproteobacteria,2K4V1@204457|Sphingomonadales	204457|Sphingomonadales	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
HKD2_k127_378206_13	335543.Sfum_2576	1.831e-06	56.0	COG2002@1|root,COG2002@2|Bacteria,1NH3J@1224|Proteobacteria,42X1Z@68525|delta/epsilon subdivisions,2WT86@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	TIGRFAM transcriptional regulator, AbrB family	-	-	-	-	-	-	-	-	-	-	-	-	MazE_antitoxin
HKD2_k127_378206_1	365528.KB891241_gene6078	2.131e-173	548.0	COG0482@1|root,COG0482@2|Bacteria,2GIUQ@201174|Actinobacteria,4ERNJ@85013|Frankiales	201174|Actinobacteria	J	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34	mnmA	-	2.8.1.13	ko:K00566	ko04122,map04122	-	R08700	RC02313,RC02315	ko00000,ko00001,ko01000,ko03016	-	-	-	tRNA_Me_trans
HKD2_k127_378206_2	675635.Psed_1775	3.731e-160	540.0	COG1104@1|root,COG1104@2|Bacteria,2GKUT@201174|Actinobacteria,4DY3B@85010|Pseudonocardiales	201174|Actinobacteria	E	Cysteine desulfurase	iscS	GO:0003674,GO:0003824,GO:0006790,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016226,GO:0016740,GO:0016782,GO:0016783,GO:0022607,GO:0031071,GO:0031163,GO:0040007,GO:0044085,GO:0044237,GO:0051186,GO:0071840	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
HKD2_k127_378206_6	298654.FraEuI1c_1000	6.8e-121	411.0	COG1215@1|root,COG1215@2|Bacteria,2I5V7@201174|Actinobacteria,4EXDQ@85013|Frankiales	201174|Actinobacteria	M	glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HKD2_k127_378206_10	298655.KI912267_gene6778	2.574e-32	128.0	COG0535@1|root,COG0535@2|Bacteria,2GQQT@201174|Actinobacteria	201174|Actinobacteria	S	Mycofactocin system	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_378206_11	525368.HMPREF0591_2244	2.221e-20	101.0	COG1487@1|root,COG1487@2|Bacteria,2ISE2@201174|Actinobacteria,23B4F@1762|Mycobacteriaceae	201174|Actinobacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	GO:0003674,GO:0003824,GO:0004518,GO:0004540,GO:0006139,GO:0006417,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009605,GO:0009607,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0016070,GO:0016787,GO:0016788,GO:0017148,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0034641,GO:0040008,GO:0043170,GO:0043207,GO:0044237,GO:0044238,GO:0044403,GO:0044419,GO:0045926,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0051701,GO:0051704,GO:0051707,GO:0060255,GO:0065007,GO:0071704,GO:0075136,GO:0080090,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360,GO:2000112,GO:2000113	-	-	-	-	-	-	-	-	-	-	PIN
HKD2_k127_378206_12	1123024.AUII01000064_gene3	1.603e-12	78.0	COG5450@1|root,COG5450@2|Bacteria,2GTYZ@201174|Actinobacteria	201174|Actinobacteria	K	Bacterial antitoxin of type II TA system, VapB	-	GO:0006417,GO:0008150,GO:0009605,GO:0009607,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0034248,GO:0034250,GO:0040008,GO:0043207,GO:0044403,GO:0044419,GO:0045727,GO:0045927,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0051701,GO:0051704,GO:0051707,GO:0060255,GO:0065007,GO:0075136,GO:0080090,GO:2000112	-	-	-	-	-	-	-	-	-	-	VapB_antitoxin
HKD2_k127_378206_9	298654.FraEuI1c_0994	2.239e-80	281.0	COG1402@1|root,COG1402@2|Bacteria,2HCRK@201174|Actinobacteria,4ESNU@85013|Frankiales	201174|Actinobacteria	S	PFAM Creatininase	mftE	-	3.5.2.10	ko:K01470	ko00330,map00330	-	R01884	RC00615	ko00000,ko00001,ko01000	-	-	-	Creatininase
HKD2_k127_378206_8	298655.KI912266_gene2190	2.702e-97	336.0	COG1028@1|root,COG1028@2|Bacteria,2ICJK@201174|Actinobacteria	201174|Actinobacteria	IQ	PFAM Short-chain dehydrogenase reductase SDR	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HKD2_k127_378206_3	326424.FRAAL5877	2.959e-143	460.0	COG2025@1|root,COG2025@2|Bacteria,2GJWH@201174|Actinobacteria,4ERY5@85013|Frankiales	201174|Actinobacteria	C	electron transfer flavoprotein, alpha subunit	etfA	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	-	ETF,ETF_alpha
HKD2_k127_378206_7	298653.Franean1_1074	5.745e-111	370.0	COG2086@1|root,COG2086@2|Bacteria,2GKV6@201174|Actinobacteria,4ES8E@85013|Frankiales	201174|Actinobacteria	C	Electron transfer flavoprotein	etfB	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0016020,GO:0016491,GO:0022900,GO:0030312,GO:0040007,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0071944	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
HKD2_k127_378206_5	710111.FraQA3DRAFT_4808	2.08e-124	405.0	COG2843@1|root,COG2843@2|Bacteria,2GK15@201174|Actinobacteria,4EUBH@85013|Frankiales	201174|Actinobacteria	M	Bacterial capsule synthesis protein PGA_cap	-	-	-	ko:K07282	-	-	-	-	ko00000	-	-	-	PGA_cap
HKD2_k127_3793947_0	656024.FsymDg_0750	0.0	1151.0	COG1197@1|root,COG1197@2|Bacteria,2GJ42@201174|Actinobacteria,4ERK2@85013|Frankiales	201174|Actinobacteria	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
HKD2_k127_3793947_1	1068980.ARVW01000001_gene2612	1.174e-70	273.0	COG1807@1|root,COG1807@2|Bacteria,2H9UZ@201174|Actinobacteria	201174|Actinobacteria	M	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3793947_2	235985.BBPN01000017_gene5584	4.643e-20	99.0	2E3HC@1|root,32YG0@2|Bacteria,2I88E@201174|Actinobacteria,2NGGS@228398|Streptacidiphilus	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3828704_2	298653.Franean1_1182	2.769e-29	123.0	COG0532@1|root,COG0532@2|Bacteria,2GKPH@201174|Actinobacteria,4ERI2@85013|Frankiales	201174|Actinobacteria	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,IF-2,IF2_N
HKD2_k127_3828704_3	298654.FraEuI1c_1101	1.683e-28	124.0	COG2740@1|root,COG2740@2|Bacteria,2GQH0@201174|Actinobacteria,4ETB1@85013|Frankiales	201174|Actinobacteria	K	Protein of unknown function (DUF448)	-	-	-	ko:K07742	-	-	-	-	ko00000	-	-	-	DUF448
HKD2_k127_3828704_0	365528.KB891241_gene6179	1.837e-175	560.0	COG0195@1|root,COG0195@2|Bacteria,2GJDJ@201174|Actinobacteria,4ERKN@85013|Frankiales	201174|Actinobacteria	K	Participates in both transcription termination and antitermination	nusA	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0016020,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0040007,GO:0043244,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KH_5,NusA_N,S1
HKD2_k127_3828704_1	656024.FsymDg_3645	7.188e-44	173.0	COG0779@1|root,COG0779@2|Bacteria,2I9BT@201174|Actinobacteria,4ETAJ@85013|Frankiales	201174|Actinobacteria	S	Required for maturation of 30S ribosomal subunits	rimP	GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576	-	ko:K09748	-	-	-	-	ko00000,ko03009	-	-	-	DUF150,DUF150_C
HKD2_k127_3877750_6	543632.JOJL01000044_gene4968	1.07e-18	96.0	COG2132@1|root,COG2132@2|Bacteria,2I8HQ@201174|Actinobacteria,4DFGD@85008|Micromonosporales	201174|Actinobacteria	Q	Multicopper oxidase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3877750_4	743718.Isova_1418	3.22e-62	224.0	COG0491@1|root,COG0491@2|Bacteria,2I9IC@201174|Actinobacteria,4F4TJ@85017|Promicromonosporaceae	201174|Actinobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HKD2_k127_3877750_1	266117.Rxyl_0311	8.583e-306	966.0	COG3408@1|root,COG3408@2|Bacteria,2ICEJ@201174|Actinobacteria	201174|Actinobacteria	G	Glycogen debranching enzyme	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3877750_0	298653.Franean1_0175	2.829e-308	951.0	COG0459@1|root,COG0459@2|Bacteria,2GKC9@201174|Actinobacteria,4ERKH@85013|Frankiales	201174|Actinobacteria	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groEL	-	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
HKD2_k127_3877750_2	365528.KB891286_gene5807	4.837e-118	397.0	COG4894@1|root,COG4894@2|Bacteria,2GMU8@201174|Actinobacteria,4ETHZ@85013|Frankiales	201174|Actinobacteria	S	Scramblase	-	-	-	-	-	-	-	-	-	-	-	-	DUF2510,Scramblase
HKD2_k127_3877750_3	365528.KB891219_gene908	2.243e-85	293.0	COG4122@1|root,COG4122@2|Bacteria,2GP7A@201174|Actinobacteria,4ETYD@85013|Frankiales	201174|Actinobacteria	S	O-methyltransferase	-	-	2.1.1.104	ko:K00588	ko00360,ko00940,ko00941,ko00945,ko01100,ko01110,map00360,map00940,map00941,map00945,map01100,map01110	M00039,M00350	R01942,R06578	RC00003,RC00392	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_3
HKD2_k127_3877750_8	1121877.JQKF01000046_gene1250	4.643e-09	66.0	28M4F@1|root,2ZAID@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3877750_7	83332.Rv0349	5.262e-11	72.0	2D5EC@1|root,32TIW@2|Bacteria,2GPZ6@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3878203_1	326424.FRAAL5722	6.446e-142	464.0	COG0477@1|root,COG0477@2|Bacteria,2GKY2@201174|Actinobacteria,4EUMC@85013|Frankiales	201174|Actinobacteria	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD2_k127_3878203_0	469371.Tbis_1422	0.0	1273.0	COG0210@1|root,COG1379@1|root,COG0210@2|Bacteria,COG1379@2|Bacteria,2I12T@201174|Actinobacteria,4DX7Y@85010|Pseudonocardiales	201174|Actinobacteria	L	UvrD/REP helicase N-terminal domain	pcrA	-	-	-	-	-	-	-	-	-	-	-	UvrD-helicase,UvrD_C
HKD2_k127_3878203_4	471852.Tcur_1520	8.557e-16	78.0	2BVHN@1|root,332R2@2|Bacteria,2IPM7@201174|Actinobacteria	201174|Actinobacteria	S	F420H(2)-dependent quinone reductase	-	-	-	-	-	-	-	-	-	-	-	-	F420H2_quin_red
HKD2_k127_3878203_2	1229780.BN381_220003	1.678e-31	130.0	COG2402@1|root,COG2402@2|Bacteria,2IRQ5@201174|Actinobacteria	201174|Actinobacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	ko:K07065	-	-	-	-	ko00000	-	-	-	PIN
HKD2_k127_3878203_3	479431.Namu_4465	4.465e-16	81.0	2DEXX@1|root,2ZPQ4@2|Bacteria,2HDEY@201174|Actinobacteria,4EWYK@85013|Frankiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3878203_5	525909.Afer_1653	1.847e-12	69.0	2984K@1|root,2ZVAJ@2|Bacteria,2GY3U@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3879518_0	106370.Francci3_4314	0.0	1033.0	COG0465@1|root,COG0465@2|Bacteria,2GJ4Q@201174|Actinobacteria,4ERQQ@85013|Frankiales	201174|Actinobacteria	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	GO:0003674,GO:0003824,GO:0004176,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009056,GO:0009057,GO:0010468,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019222,GO:0019538,GO:0030163,GO:0040007,GO:0042623,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
HKD2_k127_3879518_5	656024.FsymDg_0675	2.828e-74	282.0	COG0037@1|root,COG0634@1|root,COG0037@2|Bacteria,COG0634@2|Bacteria,2GJR4@201174|Actinobacteria,4ERWN@85013|Frankiales	201174|Actinobacteria	D	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine	tilS	GO:0008150,GO:0040007	2.4.2.8,6.3.4.19	ko:K00760,ko:K04075	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	-	R00190,R01132,R01229,R02142,R08237,R08238,R08245,R09597	RC00063,RC00122,RC02633,RC02634	ko00000,ko00001,ko01000,ko03016	-	-	-	ATP_bind_3,TilS
HKD2_k127_3879518_3	298653.Franean1_0299	1.786e-105	352.0	COG0037@1|root,COG0634@1|root,COG0037@2|Bacteria,COG0634@2|Bacteria,2GJR4@201174|Actinobacteria,4ERWN@85013|Frankiales	201174|Actinobacteria	D	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine	tilS	GO:0008150,GO:0040007	2.4.2.8,6.3.4.19	ko:K00760,ko:K04075	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	-	R00190,R01132,R01229,R02142,R08237,R08238,R08245,R09597	RC00063,RC00122,RC02633,RC02634	ko00000,ko00001,ko01000,ko03016	-	-	-	ATP_bind_3,TilS
HKD2_k127_3879518_1	656024.FsymDg_0676	1.209e-175	556.0	COG5282@1|root,COG5282@2|Bacteria,2GJ8E@201174|Actinobacteria,4ERVP@85013|Frankiales	201174|Actinobacteria	S	Zincin-like metallopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Zincin_2
HKD2_k127_3879518_2	326424.FRAAL6585	9.971e-124	414.0	COG2027@1|root,COG2027@2|Bacteria,2GJPH@201174|Actinobacteria,4ESEH@85013|Frankiales	201174|Actinobacteria	M	PFAM Peptidase S13, D-Ala-D-Ala carboxypeptidase C	dacB	-	3.4.16.4	ko:K07259	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	Peptidase_S13
HKD2_k127_3879518_4	298655.KI912266_gene1488	2.026e-92	305.0	COG0221@1|root,COG0221@2|Bacteria,2GM7F@201174|Actinobacteria,4ESEE@85013|Frankiales	201174|Actinobacteria	C	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions	ppa	GO:0000287,GO:0003674,GO:0003824,GO:0004427,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0043167,GO:0043169,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0071944	3.6.1.1	ko:K01507	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	iNJ661.Rv3628	Pyrophosphatase
HKD2_k127_3907076_2	656024.FsymDg_1089	1.251e-41	155.0	COG3824@1|root,COG3824@2|Bacteria,2IS6W@201174|Actinobacteria,4ET0J@85013|Frankiales	201174|Actinobacteria	S	Zincin-like metallopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Zincin_1
HKD2_k127_3907076_3	298653.Franean1_5864	5.979e-38	147.0	2CC1Y@1|root,32RUK@2|Bacteria,2IQ4Q@201174|Actinobacteria,4ET3Z@85013|Frankiales	201174|Actinobacteria	K	Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA	whiB2	-	-	ko:K18955	-	-	-	-	ko00000,ko03000	-	-	-	Whib
HKD2_k127_3907076_0	326424.FRAAL1263	0.0	1347.0	COG1060@1|root,COG1060@2|Bacteria,2GK83@201174|Actinobacteria,4ES7E@85013|Frankiales	201174|Actinobacteria	H	SMART Elongator protein 3 MiaB NifB	fbiC	-	2.5.1.77	ko:K11779	ko00680,ko01120,map00680,map01120	M00378	R09396	RC01381,RC03002,RC03007	ko00000,ko00001,ko00002,ko01000	-	-	-	Radical_SAM
HKD2_k127_3907076_1	656024.FsymDg_1077	9.332e-117	383.0	COG0391@1|root,COG0391@2|Bacteria,2GJZ2@201174|Actinobacteria,4ERBV@85013|Frankiales	201174|Actinobacteria	S	tigrfam lppg	cofD	GO:0003674,GO:0003824,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016740,GO:0016772,GO:0016773,GO:0043743,GO:0044237,GO:0044249,GO:0051186,GO:0051188	2.7.8.28	ko:K11212	ko00680,ko01120,map00680,map01120	M00378	R09398	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	UPF0052
HKD2_k127_3927242_8	326424.FRAAL2214	8.596e-06	49.0	2EGQJ@1|root,33AGQ@2|Bacteria,2IADM@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3927242_7	298653.Franean1_5080	5.844e-62	228.0	COG2802@1|root,COG2802@2|Bacteria,2GNWA@201174|Actinobacteria,4ET5K@85013|Frankiales	201174|Actinobacteria	S	Peptidase S16, lon domain protein	-	-	3.4.21.53	ko:K01338,ko:K07157	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	LON_substr_bdg
HKD2_k127_3927242_0	656024.FsymDg_2502	8.262e-204	641.0	COG0141@1|root,COG0141@2|Bacteria,2GKKA@201174|Actinobacteria,4ERSZ@85013|Frankiales	201174|Actinobacteria	E	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine	hisD	GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0030312,GO:0034641,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.1.1.23	ko:K00013	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01158,R01163,R03012	RC00099,RC00242,RC00463	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv1599	Histidinol_dh
HKD2_k127_3927242_1	222534.KB893733_gene5960	3.302e-162	541.0	COG0079@1|root,COG0079@2|Bacteria,2GJ9W@201174|Actinobacteria,4ERD9@85013|Frankiales	201174|Actinobacteria	E	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily	hisC	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
HKD2_k127_3927242_5	656024.FsymDg_2500	5.916e-95	339.0	COG0131@1|root,COG0131@2|Bacteria,2GKMD@201174|Actinobacteria,4ESDH@85013|Frankiales	201174|Actinobacteria	E	Imidazoleglycerol-phosphate dehydratase	hisB	GO:0000105,GO:0003674,GO:0003824,GO:0004424,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	3.1.3.15,4.2.1.19	ko:K01089,ko:K01693	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R03013,R03457	RC00017,RC00932	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPD
HKD2_k127_3927242_4	298655.KI912267_gene7202	6.206e-98	334.0	COG0118@1|root,COG0118@2|Bacteria,2GIYS@201174|Actinobacteria,4ES6K@85013|Frankiales	201174|Actinobacteria	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR	hisH	GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030312,GO:0040007,GO:0044464,GO:0071944	-	ko:K02501	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
HKD2_k127_3927242_3	710111.FraQA3DRAFT_6530	4.132e-118	383.0	COG0106@1|root,COG0106@2|Bacteria,2GJ4V@201174|Actinobacteria,4ES15@85013|Frankiales	201174|Actinobacteria	E	1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase	hisA	GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0040007,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	5.3.1.16,5.3.1.24	ko:K01814,ko:K01817	ko00340,ko00400,ko01100,ko01110,ko01130,ko01230,map00340,map00400,map01100,map01110,map01130,map01230	M00023,M00026	R03509,R04640	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
HKD2_k127_3927242_2	298654.FraEuI1c_4983	5.719e-130	419.0	COG0107@1|root,COG0107@2|Bacteria,2GIRP@201174|Actinobacteria,4ES76@85013|Frankiales	201174|Actinobacteria	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit	hisF	GO:0000107,GO:0003674,GO:0003824,GO:0008150,GO:0016740,GO:0016757,GO:0016763,GO:0040007	4.1.3.27	ko:K01657,ko:K02500	ko00340,ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00340,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023,M00026	R00985,R00986,R04558	RC00010,RC01190,RC01943,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
HKD2_k127_3927242_6	298653.Franean1_1925	1.119e-88	301.0	COG1132@1|root,COG1132@2|Bacteria,2GITR@201174|Actinobacteria,4EUMQ@85013|Frankiales	201174|Actinobacteria	V	ABC transporter, transmembrane region	-	-	-	-	-	-	-	-	-	-	-	-	ABC_membrane,ABC_tran
HKD2_k127_3949747_3	222534.KB893748_gene2766	3.401e-82	278.0	COG0039@1|root,COG0039@2|Bacteria,2GN5S@201174|Actinobacteria,4ESBM@85013|Frankiales	201174|Actinobacteria	C	Catalyzes the reversible oxidation of malate to oxaloacetate	mdh	-	1.1.1.27,1.1.1.37	ko:K00016,ko:K00024	ko00010,ko00020,ko00270,ko00620,ko00630,ko00640,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04922,map00010,map00020,map00270,map00620,map00630,map00640,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200,map04922	M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740	R00342,R00703,R01000,R03104,R07136	RC00031,RC00044	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Ldh_1_C,Ldh_1_N
HKD2_k127_3949747_1	1128421.JAGA01000002_gene497	1.2e-160	513.0	COG0473@1|root,COG0473@2|Bacteria,2NP0Z@2323|unclassified Bacteria	2|Bacteria	CE	Isocitrate/isopropylmalate dehydrogenase	icd	-	1.1.1.41	ko:K00030	ko00020,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010	R00709	RC00114	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
HKD2_k127_3949747_7	1048339.KB913029_gene3745	6.327e-15	86.0	COG0739@1|root,COG0739@2|Bacteria,2IBVX@201174|Actinobacteria	201174|Actinobacteria	M	Membrane proteins related to metalloendopeptidases	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
HKD2_k127_3949747_5	765420.OSCT_3060	6.763e-30	134.0	COG0739@1|root,COG0739@2|Bacteria,2GADD@200795|Chloroflexi,375JT@32061|Chloroflexia	32061|Chloroflexia	M	Peptidase family M23	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
HKD2_k127_3949747_6	1380356.JNIK01000018_gene556	7.851e-17	91.0	2DRQP@1|root,33CNM@2|Bacteria,2GYKP@201174|Actinobacteria,4ETI7@85013|Frankiales	201174|Actinobacteria	S	Protein of unknown function (DUF3017)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3017
HKD2_k127_3949747_8	309800.C498_04725	6.905e-14	77.0	COG3603@1|root,arCOG05233@2157|Archaea,2XZ6K@28890|Euryarchaeota,23X5Q@183963|Halobacteria	183963|Halobacteria	S	ACT domain	-	-	-	ko:K09707	-	-	-	-	ko00000	-	-	-	ACT_7
HKD2_k127_3949747_4	479432.Sros_1251	3.74e-74	269.0	COG1716@1|root,COG1716@2|Bacteria,2I915@201174|Actinobacteria,4EFKU@85012|Streptosporangiales	201174|Actinobacteria	T	Forkhead associated domain	-	-	-	-	-	-	-	-	-	-	-	-	FHA
HKD2_k127_3949747_2	1120950.KB892747_gene3727	1.273e-133	431.0	COG0190@1|root,COG0190@2|Bacteria,2GJZS@201174|Actinobacteria,4DNC5@85009|Propionibacteriales	201174|Actinobacteria	H	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate	folD	GO:0003674,GO:0003824,GO:0004477,GO:0004488,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0019238,GO:0040007,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0071944	1.5.1.5,3.5.4.9	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R01220,R01655	RC00202,RC00578	ko00000,ko00001,ko00002,ko01000	-	-	-	THF_DHG_CYH,THF_DHG_CYH_C
HKD2_k127_3949747_0	298653.Franean1_5974	3.293e-217	681.0	COG0138@1|root,COG0299@1|root,COG0138@2|Bacteria,COG0299@2|Bacteria,2GJWU@201174|Actinobacteria,4ERS9@85013|Frankiales	201174|Actinobacteria	F	Bifunctional purine biosynthesis protein PurH	purH	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AICARFT_IMPCHas,MGS
HKD2_k127_3952815_2	1041159.AZUW01000012_gene2283	6.691e-44	165.0	COG3742@1|root,COG3742@2|Bacteria,1N937@1224|Proteobacteria,2UFYN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	ko:K19686	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PIN
HKD2_k127_3952815_4	246196.MSMEI_1245	7.67e-23	101.0	COG4423@1|root,COG4423@2|Bacteria,2GW0J@201174|Actinobacteria,23E40@1762|Mycobacteriaceae	201174|Actinobacteria	K	Antitoxin component of a type II toxin-antitoxin (TA) system. Upon	-	GO:0008150,GO:0040008,GO:0045927,GO:0048518,GO:0050789,GO:0065007	-	ko:K19687	-	-	-	-	ko00000,ko02048	-	-	-	PSK_trans_fac
HKD2_k127_3952815_0	882083.SacmaDRAFT_4647	1.113e-82	284.0	2DQF9@1|root,336H4@2|Bacteria,2I78I@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3952815_1	266940.Krad_0790	5.207e-48	175.0	COG4994@1|root,COG4994@2|Bacteria	2|Bacteria	K	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440
HKD2_k127_3952815_3	365528.KB891214_gene2436	9.443e-30	126.0	COG0484@1|root,COG0484@2|Bacteria	2|Bacteria	O	heat shock protein binding	-	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DUF3099,DnaJ
HKD2_k127_3956620_1	1394178.AWOO02000017_gene6758	6.685e-30	129.0	COG3745@1|root,COG3745@2|Bacteria,2GQJH@201174|Actinobacteria,4EKC2@85012|Streptosporangiales	201174|Actinobacteria	U	SAF	-	-	-	-	-	-	-	-	-	-	-	-	ChapFlgA,RcpC,SAF
HKD2_k127_3956620_0	1120949.KB903313_gene395	2.27e-117	384.0	COG0005@1|root,COG0005@2|Bacteria,2GKGG@201174|Actinobacteria,4DA0V@85008|Micromonosporales	201174|Actinobacteria	F	Purine nucleoside phosphorylase involved in purine salvage	mtnP	-	2.4.2.28	ko:K00772	ko00270,ko01100,map00270,map01100	M00034	R01402	RC00063,RC02819	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
HKD2_k127_3956620_2	219305.MCAG_03501	7.006e-28	115.0	COG2331@1|root,COG2331@2|Bacteria,2IQHE@201174|Actinobacteria,4DF8Z@85008|Micromonosporales	201174|Actinobacteria	S	Putative regulatory protein	-	-	-	-	-	-	-	-	-	-	-	-	Zn-ribbon_8
HKD2_k127_3970823_8	1968.JOEV01000007_gene4009	5.236e-112	370.0	COG0604@1|root,COG0604@2|Bacteria,2GIWC@201174|Actinobacteria	201174|Actinobacteria	C	alcohol dehydrogenase	-	-	-	ko:K14629	ko01057,ko01130,map01057,map01130	M00779	R06695	RC02067	ko00000,ko00001,ko00002,ko01008	-	-	-	ADH_N,ADH_zinc_N,ADH_zinc_N_2
HKD2_k127_3970823_2	100226.SCO5076	3.85e-201	639.0	COG0477@1|root,COG2814@2|Bacteria,2H4H5@201174|Actinobacteria	201174|Actinobacteria	EGP	Major facilitator Superfamily	-	-	-	ko:K05557	-	-	-	-	ko00000,ko02000	2.A.1.3.7	-	-	MFS_1
HKD2_k127_3970823_14	1968.JOEV01000007_gene4007	1.492e-52	188.0	COG3467@1|root,COG3467@2|Bacteria,2IR80@201174|Actinobacteria	201174|Actinobacteria	S	pyridoxamine 5-phosphate	-	-	-	ko:K05558	-	-	-	-	ko00000	-	-	-	Putative_PNPOx
HKD2_k127_3970823_10	1968.JOEV01000007_gene4006	5.524e-95	319.0	2B61M@1|root,31YXW@2|Bacteria,2IBG0@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3970823_5	1968.JOEV01000007_gene4005	4.638e-148	473.0	COG0702@1|root,COG0702@2|Bacteria,2GK1A@201174|Actinobacteria	201174|Actinobacteria	GM	NmrA family	-	-	-	-	-	-	-	-	-	-	-	-	NmrA
HKD2_k127_3970823_4	100226.SCO5080	5.825e-162	519.0	COG1960@1|root,COG1960@2|Bacteria,2GMKM@201174|Actinobacteria	201174|Actinobacteria	I	acyl-CoA dehydrogenase	-	-	-	ko:K14630	ko01057,ko01130,map01057,map01130	M00779	R09313,R09314	RC00046,RC01675	ko00000,ko00001,ko00002,ko01000,ko01008	-	-	-	Acyl-CoA_dh_2,Acyl-CoA_dh_N
HKD2_k127_3970823_15	1968.JOEV01000007_gene4003	1.044e-38	153.0	COG1359@1|root,COG1359@2|Bacteria,2IKYW@201174|Actinobacteria	201174|Actinobacteria	S	Antibiotic biosynthesis monooxygenase	-	-	-	ko:K14632	ko01057,ko01130,map01057,map01130	M00779	R06696	RC01675	ko00000,ko00001,ko00002,ko01008	-	-	-	ABM
HKD2_k127_3970823_0	1155718.KB891896_gene2282	1.106e-225	706.0	COG0304@1|root,COG0304@2|Bacteria,2GIY4@201174|Actinobacteria	201174|Actinobacteria	IQ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	-	-	2.3.1.235,2.3.1.260	ko:K05551	ko00253,ko01056,ko01130,map00253,map01056,map01130	M00778	R06635,R06637,R06641,R06643,R06644,R06645,R09258,R09259,R10960,R11516	RC00004,RC00039,RC02545,RC02728,RC02729,RC02931,RC02932,RC02947	ko00000,ko00001,ko00002,ko01000,ko01004,ko01008	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
HKD2_k127_3970823_3	103733.JNYO01000015_gene3554	7.159e-187	595.0	COG0304@1|root,COG0304@2|Bacteria,2GXFY@201174|Actinobacteria,4E9HT@85010|Pseudonocardiales	201174|Actinobacteria	IQ	Beta-ketoacyl synthase, C-terminal domain	-	-	2.3.1.235,2.3.1.260	ko:K05552	ko00253,ko01056,ko01130,map00253,map01056,map01130	M00778	R06635,R06637,R06641,R06643,R06644,R06645,R09258,R09259,R10960,R11516	RC00004,RC00039,RC02545,RC02728,RC02729,RC02931,RC02932,RC02947	ko00000,ko00001,ko00002,ko01000,ko01004,ko01008	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
HKD2_k127_3970823_17	1155718.KB891896_gene2284	1.705e-21	104.0	COG0236@1|root,COG0236@2|Bacteria,2GR2I@201174|Actinobacteria	201174|Actinobacteria	IQ	Phosphopantetheine attachment site	-	-	-	ko:K05553	ko00253,ko01056,ko01130,map00253,map01056,map01130	M00778	R06635,R06637,R06641,R06643,R06644,R06645,R09258,R09259,R10960,R11516	RC00004,RC00039,RC02545,RC02728,RC02729,RC02931,RC02932,RC02947	ko00000,ko00001,ko00002,ko01004,ko01008	-	-	-	PP-binding
HKD2_k127_3970823_7	1961.JOAK01000010_gene6632	3.779e-120	392.0	COG2867@1|root,COG2867@2|Bacteria,2GIW9@201174|Actinobacteria	201174|Actinobacteria	I	Polyketide cyclase / dehydrase and lipid transport	-	-	-	ko:K05554	ko01056,ko01130,map01056,map01130	M00778	R09265	RC02546	ko00000,ko00001,ko00002,ko01000,ko01004,ko01008	-	-	-	Polyketide_cyc,Polyketide_cyc2
HKD2_k127_3970823_11	100226.SCO5082	1.81e-92	319.0	COG1309@1|root,COG1309@2|Bacteria,2GNBS@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C,TetR_N
HKD2_k127_3970823_1	1968.JOEV01000007_gene4001	1.739e-221	700.0	COG0477@1|root,COG0477@2|Bacteria,2GIUM@201174|Actinobacteria	201174|Actinobacteria	EGP	Major facilitator superfamily	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD2_k127_3970823_6	1150864.MILUP08_45304	1.907e-130	439.0	COG0702@1|root,COG0702@2|Bacteria,2GK1A@201174|Actinobacteria,4DCV3@85008|Micromonosporales	201174|Actinobacteria	GM	NmrA-like family	-	-	-	-	-	-	-	-	-	-	-	-	NmrA
HKD2_k127_3970823_12	765420.OSCT_0066	1.845e-86	305.0	COG0469@1|root,COG0469@2|Bacteria,2G5YE@200795|Chloroflexi,375C1@32061|Chloroflexia	32061|Chloroflexia	G	Belongs to the pyruvate kinase family	-	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PK,PK_C
HKD2_k127_3970823_18	1463856.JOHY01000046_gene4043	2.347e-18	91.0	COG1846@1|root,COG1846@2|Bacteria,2GSQ8@201174|Actinobacteria	201174|Actinobacteria	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
HKD2_k127_3970823_13	43759.JNWK01000029_gene5378	2.768e-79	277.0	COG1252@1|root,COG1252@2|Bacteria,2GNAT@201174|Actinobacteria	201174|Actinobacteria	C	pyridine nucleotide-disulfide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2
HKD2_k127_3970823_9	1123320.KB889681_gene2593	2.157e-106	368.0	COG1070@1|root,COG1070@2|Bacteria,2GNCR@201174|Actinobacteria	201174|Actinobacteria	G	Belongs to the FGGY kinase family	-	-	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
HKD2_k127_3970823_16	1123320.KB889681_gene2594	1.048e-33	133.0	COG1063@1|root,COG1063@2|Bacteria,2GKC7@201174|Actinobacteria	201174|Actinobacteria	E	alcohol dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
HKD2_k127_3987117_4	1206733.BAGC01000053_gene3059	4.285e-18	98.0	COG4635@1|root,COG4635@2|Bacteria,2IMZZ@201174|Actinobacteria,4G2NQ@85025|Nocardiaceae	201174|Actinobacteria	CH	Flavodoxin domain	-	-	1.3.5.3	ko:K00230	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R09489	RC00885	ko00000,ko00001,ko00002,ko01000	-	-	-	Flavodoxin_5
HKD2_k127_3987117_1	266940.Krad_1838	1.37e-98	334.0	COG2013@1|root,COG2013@2|Bacteria,2GMD3@201174|Actinobacteria	201174|Actinobacteria	S	Mitochondrial biogenesis AIM24	-	-	-	-	-	-	-	-	-	-	-	-	AIM24
HKD2_k127_3987117_5	105422.BBPM01000002_gene5098	3.376e-17	81.0	COG2013@1|root,COG2013@2|Bacteria,2GMA8@201174|Actinobacteria,2NH7Q@228398|Streptacidiphilus	201174|Actinobacteria	S	Mitochondrial biogenesis AIM24	-	-	-	-	-	-	-	-	-	-	-	-	AIM24
HKD2_k127_3987117_3	266940.Krad_1839	7.946e-45	173.0	COG2013@1|root,COG2013@2|Bacteria,2GMA8@201174|Actinobacteria	201174|Actinobacteria	S	Mitochondrial biogenesis AIM24	-	-	-	-	-	-	-	-	-	-	-	-	AIM24
HKD2_k127_3987117_2	1449068.JMLQ01000001_gene688	3.47e-71	248.0	COG2013@1|root,COG2013@2|Bacteria,2GNEK@201174|Actinobacteria,4FU7P@85025|Nocardiaceae	201174|Actinobacteria	S	Mitochondrial biogenesis AIM24	-	-	-	-	-	-	-	-	-	-	-	-	AIM24
HKD2_k127_3987117_0	106370.Francci3_1626	3.152e-113	368.0	COG0556@1|root,COG0556@2|Bacteria,2GJ03@201174|Actinobacteria,4ERJA@85013|Frankiales	201174|Actinobacteria	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	GO:0002682,GO:0002684,GO:0005575,GO:0005623,GO:0005886,GO:0006950,GO:0008150,GO:0009605,GO:0009607,GO:0016020,GO:0035821,GO:0043207,GO:0044003,GO:0044403,GO:0044419,GO:0044464,GO:0048518,GO:0048583,GO:0048584,GO:0050776,GO:0050778,GO:0050789,GO:0050896,GO:0051409,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0052031,GO:0052173,GO:0052200,GO:0052255,GO:0052552,GO:0052553,GO:0052555,GO:0052556,GO:0052564,GO:0052572,GO:0065007,GO:0071944,GO:0075136	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
HKD2_k127_3988296_2	33876.JNXY01000024_gene4966	3.414e-28	120.0	COG1846@1|root,COG1846@2|Bacteria,2GMDI@201174|Actinobacteria,4DC02@85008|Micromonosporales	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3988296_0	710111.FraQA3DRAFT_0378	5.071e-79	273.0	COG2197@1|root,COG2197@2|Bacteria,2I8Y7@201174|Actinobacteria	201174|Actinobacteria	KT	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg,Sigma70_r4_2
HKD2_k127_3988296_3	298655.KI912266_gene6486	3.651e-27	123.0	COG4585@1|root,COG4585@2|Bacteria,2HQ5W@201174|Actinobacteria,4EW5B@85013|Frankiales	201174|Actinobacteria	T	Evidence 5 No homology to any previously reported sequences	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4030752_6	591157.SSLG_05145	5.743e-38	144.0	COG3293@1|root,COG3293@2|Bacteria,2IIAY@201174|Actinobacteria	201174|Actinobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_2,DUF4096
HKD2_k127_4030752_9	298655.KI912266_gene1664	9.321e-18	93.0	COG3293@1|root,COG3293@2|Bacteria	2|Bacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4096
HKD2_k127_4030752_3	1122939.ATUD01000002_gene1370	6.954e-61	212.0	COG1487@1|root,COG1487@2|Bacteria,2INNM@201174|Actinobacteria	201174|Actinobacteria	S	ribonuclease activity	-	-	-	-	-	-	-	-	-	-	-	-	PIN
HKD2_k127_4030752_8	1122939.ATUD01000002_gene1371	1.084e-26	110.0	COG2002@1|root,COG2002@2|Bacteria	2|Bacteria	K	toxin-antitoxin pair type II binding	-	-	-	-	-	-	-	-	-	-	-	-	MazE_antitoxin
HKD2_k127_4030752_2	1121017.AUFG01000002_gene2812	4.983e-63	227.0	COG5485@1|root,COG5485@2|Bacteria,2IMH5@201174|Actinobacteria	201174|Actinobacteria	S	SnoaL-like polyketide cyclase	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL
HKD2_k127_4030752_5	1122609.AUGT01000024_gene360	1.33e-44	173.0	COG1917@1|root,COG1917@2|Bacteria	2|Bacteria	L	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CHRD,Cupin_2
HKD2_k127_4030752_1	1151119.KB895489_gene500	9.412e-77	263.0	COG1309@1|root,COG1309@2|Bacteria,2IJP2@201174|Actinobacteria	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_11,TetR_N
HKD2_k127_4030752_0	1283299.AUKG01000002_gene4715	1.105e-102	353.0	COG2837@1|root,COG2837@2|Bacteria,2GND2@201174|Actinobacteria	201174|Actinobacteria	P	Dyp-type peroxidase family	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4030752_7	1283299.AUKG01000002_gene4714	1.545e-31	130.0	COG2837@1|root,COG2837@2|Bacteria	2|Bacteria	P	iron assimilation	-	-	-	-	-	-	-	-	-	-	-	-	Dyp_perox
HKD2_k127_4030752_4	1246995.AFR_25100	7.944e-47	180.0	2DBRK@1|root,2ZAME@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4079172_2	326424.FRAAL1281	8.807e-08	61.0	COG0744@1|root,COG0744@2|Bacteria,2GK21@201174|Actinobacteria,4ERGQ@85013|Frankiales	201174|Actinobacteria	M	PFAM glycosyl transferase, family 51	pon1	-	-	-	-	-	-	-	-	-	-	-	PASTA,Transgly,Transpeptidase
HKD2_k127_4079172_0	1048339.KB913029_gene5025	2.787e-142	469.0	COG0420@1|root,COG0420@2|Bacteria,2GK9R@201174|Actinobacteria,4ES4J@85013|Frankiales	201174|Actinobacteria	L	SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'- 5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity	sbcD	-	-	ko:K03547	-	-	-	-	ko00000,ko03400	-	-	-	Metallophos,SbcD_C
HKD2_k127_4079172_1	1048339.KB913029_gene5026	5.217e-99	365.0	COG0419@1|root,COG0419@2|Bacteria,2GKYR@201174|Actinobacteria,4ERV4@85013|Frankiales	201174|Actinobacteria	L	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	sbcC	-	-	ko:K03546	-	-	-	-	ko00000,ko03400	-	-	-	AAA_23,SbcCD_C
HKD2_k127_4091059_4	749927.AMED_1263	8.208e-55	201.0	COG0477@1|root,COG2814@2|Bacteria,2HCHA@201174|Actinobacteria,4E1VJ@85010|Pseudonocardiales	201174|Actinobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD2_k127_4091059_8	222534.KB893717_gene2167	4.102e-15	78.0	2EGRW@1|root,33AI2@2|Bacteria,2IQF3@201174|Actinobacteria,4ETFR@85013|Frankiales	201174|Actinobacteria	S	Protein of unknown function (DUF3073)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3073
HKD2_k127_4091059_0	479432.Sros_8995	1.039e-156	511.0	COG0334@1|root,COG0334@2|Bacteria,2GKXG@201174|Actinobacteria,4EHC5@85012|Streptosporangiales	201174|Actinobacteria	E	Glutamate/Leucine/Phenylalanine/Valine dehydrogenase	vdh	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	1.4.1.23	ko:K00271	ko00280,ko01100,ko01110,ko01130,map00280,map01100,map01110,map01130	-	R01212,R01434	RC00036	ko00000,ko00001,ko01000	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
HKD2_k127_4091059_1	656024.FsymDg_0278	1.769e-112	374.0	2BPHM@1|root,32IA4@2|Bacteria,2GM2J@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4091059_6	656024.FsymDg_0279	1.037e-31	124.0	COG2452@1|root,COG2452@2|Bacteria,2GQJ9@201174|Actinobacteria,4ETDG@85013|Frankiales	201174|Actinobacteria	L	TIGRFAM DNA binding domain	bldC	-	-	-	-	-	-	-	-	-	-	-	HTH_17
HKD2_k127_4091059_11	1121017.AUFG01000007_gene1240	6.764e-08	59.0	2BRPR@1|root,32KPC@2|Bacteria,2HBY1@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4091059_14	1146883.BLASA_4612	0.0006343	43.0	COG4974@1|root,COG4974@2|Bacteria,2HD2H@201174|Actinobacteria	201174|Actinobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_3,Phage_integrase
HKD2_k127_4091059_3	477641.MODMU_0715	6.41e-79	280.0	COG0582@1|root,COG0582@2|Bacteria,2IHIW@201174|Actinobacteria,4EURT@85013|Frankiales	201174|Actinobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Arm-DNA-bind_4,Phage_int_SAM_3,Phage_integrase
HKD2_k127_4091059_2	882083.SacmaDRAFT_4134	2.512e-105	363.0	COG0863@1|root,COG0863@2|Bacteria,2I9DJ@201174|Actinobacteria	201174|Actinobacteria	L	Belongs to the N(4) N(6)-methyltransferase family	-	-	2.1.1.113,2.1.1.72	ko:K00571,ko:K00590	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
HKD2_k127_4091059_7	436229.JOEH01000047_gene7451	3.452e-26	121.0	COG3266@1|root,COG3266@2|Bacteria,2HQSJ@201174|Actinobacteria,2NMH1@228398|Streptacidiphilus	201174|Actinobacteria	S	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4091059_10	134676.ACPL_5958	8.954e-11	74.0	COG1674@1|root,COG1674@2|Bacteria	2|Bacteria	D	ftsk spoiiie	-	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	DUF3631,FtsK_SpoIIIE
HKD2_k127_4091059_5	656024.FsymDg_1279	6.2e-50	195.0	COG1378@1|root,COG1378@2|Bacteria,2I5VK@201174|Actinobacteria	201174|Actinobacteria	K	Sugar-specific transcriptional regulator TrmB	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4091059_13	298653.Franean1_2661	0.0002886	50.0	COG4734@1|root,COG4734@2|Bacteria,2IQRG@201174|Actinobacteria,4EW4U@85013|Frankiales	201174|Actinobacteria	S	Antirestriction protein (ArdA)	-	-	-	-	-	-	-	-	-	-	-	-	ArdA
HKD2_k127_4112247_2	1123320.KB889574_gene5511	2.003e-164	525.0	COG0516@1|root,COG0516@2|Bacteria,2GKVS@201174|Actinobacteria	201174|Actinobacteria	F	IMP dehydrogenase	guaB3	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006183,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	IMPDH
HKD2_k127_4112247_1	656024.FsymDg_3909	4.161e-248	780.0	COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,2GITZ@201174|Actinobacteria,4ERYK@85013|Frankiales	201174|Actinobacteria	F	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth	guaB	GO:0003674,GO:0003824,GO:0003938,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006183,GO:0006195,GO:0006204,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009125,GO:0009126,GO:0009127,GO:0009128,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009154,GO:0009156,GO:0009158,GO:0009161,GO:0009163,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009169,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009261,GO:0009987,GO:0016020,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0030312,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0040007,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046037,GO:0046039,GO:0046040,GO:0046128,GO:0046129,GO:0046390,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0072523,GO:0090407,GO:0097292,GO:0097293,GO:1901068,GO:1901070,GO:1901135,GO:1901136,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901657,GO:1901659	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,IMPDH
HKD2_k127_4112247_6	298655.KI912266_gene261	4.424e-64	223.0	2DHRC@1|root,32U9K@2|Bacteria,2II2K@201174|Actinobacteria,4EWIB@85013|Frankiales	201174|Actinobacteria	S	Family of unknown function (DUF5319)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5319
HKD2_k127_4112247_5	656024.FsymDg_3911	5.104e-85	297.0	COG0789@1|root,COG0789@2|Bacteria,2I8T8@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	-	-	-	ko:K22491	-	-	-	-	ko00000,ko03000	-	-	-	B12-binding_2,MerR_1
HKD2_k127_4112247_8	298653.Franean1_6000	2.387e-42	156.0	2CC1Y@1|root,32S23@2|Bacteria,2IQS5@201174|Actinobacteria,4ET5H@85013|Frankiales	201174|Actinobacteria	K	Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA	whiB3	-	-	ko:K18955	-	-	-	-	ko00000,ko03000	-	-	-	Whib
HKD2_k127_4112247_3	469371.Tbis_2561	6.59e-138	450.0	COG0007@1|root,COG1648@1|root,COG0007@2|Bacteria,COG1648@2|Bacteria,2GK3B@201174|Actinobacteria,4DYZE@85010|Pseudonocardiales	201174|Actinobacteria	H	Uroporphyrin-III C-methyltransferase	cysG	-	1.3.1.76,2.1.1.107,4.99.1.4	ko:K02302,ko:K02303	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02864,R03194,R03947	RC00003,RC00871,RC01012,RC01034	ko00000,ko00001,ko00002,ko01000	-	-	-	NAD_binding_7,TP_methylase
HKD2_k127_4112247_0	656024.FsymDg_3913	1.048e-257	805.0	COG0459@1|root,COG0459@2|Bacteria,2GKC9@201174|Actinobacteria,4ES4F@85013|Frankiales	201174|Actinobacteria	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL2	GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006457,GO:0006458,GO:0006725,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0009266,GO:0009295,GO:0009408,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016020,GO:0016043,GO:0016465,GO:0030312,GO:0031668,GO:0032991,GO:0033554,GO:0034641,GO:0040007,GO:0042026,GO:0042262,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043388,GO:0043590,GO:0044093,GO:0044183,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046483,GO:0050896,GO:0051082,GO:0051098,GO:0051099,GO:0051101,GO:0051716,GO:0061077,GO:0065007,GO:0065009,GO:0071496,GO:0071704,GO:0071840,GO:0071944,GO:0090143,GO:0090304,GO:0097159,GO:0101031,GO:1901360,GO:1901363,GO:1990220,GO:2000677,GO:2000679	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
HKD2_k127_4112247_7	326424.FRAAL1133	1.868e-47	178.0	COG0234@1|root,COG0234@2|Bacteria,2IKTH@201174|Actinobacteria,4ET07@85013|Frankiales	201174|Actinobacteria	O	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter	groS	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006355,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010033,GO:0010468,GO:0010556,GO:0016020,GO:0019219,GO:0019222,GO:0019899,GO:0030312,GO:0031323,GO:0031326,GO:0033554,GO:0034605,GO:0035375,GO:0035966,GO:0040007,GO:0042221,GO:0043167,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0046872,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0061077,GO:0065007,GO:0071944,GO:0080090,GO:1903506,GO:2000112,GO:2001141	-	ko:K04078	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Cpn10
HKD2_k127_4112247_4	656024.FsymDg_3915	4.287e-94	310.0	COG0451@1|root,COG0451@2|Bacteria,2I2EG@201174|Actinobacteria,4EUA3@85013|Frankiales	201174|Actinobacteria	GM	epimerase dehydratase	-	-	4.2.1.46,5.1.3.2	ko:K01710,ko:K01784	ko00052,ko00520,ko00521,ko00523,ko00525,ko01055,ko01100,ko01130,map00052,map00520,map00521,map00523,map00525,map01055,map01100,map01130	M00361,M00362,M00632,M00793	R00291,R02984,R06513	RC00289,RC00402	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
HKD2_k127_4197360_3	656024.FsymDg_0046	2.832e-105	348.0	COG0582@1|root,COG0582@2|Bacteria,2GISN@201174|Actinobacteria,4ETQW@85013|Frankiales	201174|Actinobacteria	L	Phage integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_3,Phage_integrase
HKD2_k127_4197360_11	1089455.MOPEL_029_00800	0.0007219	50.0	COG1674@1|root,COG1674@2|Bacteria,2GJBR@201174|Actinobacteria,4F69F@85018|Dermatophilaceae	201174|Actinobacteria	D	FtsK/SpoIIIE family	-	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_SpoIIIE
HKD2_k127_4197360_0	1382306.JNIM01000001_gene1083	1.061e-293	944.0	COG1674@1|root,COG1674@2|Bacteria,2G5Y3@200795|Chloroflexi	200795|Chloroflexi	D	PFAM cell divisionFtsK SpoIIIE	-	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_SpoIIIE
HKD2_k127_4197360_6	298655.KI912266_gene5222	9.665e-57	207.0	arCOG03175@1|root,32RFA@2|Bacteria,2IFE3@201174|Actinobacteria,4ETF5@85013|Frankiales	201174|Actinobacteria	D	sporulation and cell division protein, SsgA	ssgB	GO:0000003,GO:0000910,GO:0005575,GO:0005618,GO:0005623,GO:0006082,GO:0006725,GO:0006732,GO:0007049,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009653,GO:0009987,GO:0010564,GO:0010927,GO:0016043,GO:0016053,GO:0016999,GO:0017000,GO:0017144,GO:0018130,GO:0018958,GO:0019438,GO:0019748,GO:0019752,GO:0019954,GO:0022402,GO:0022607,GO:0030154,GO:0030312,GO:0030428,GO:0030435,GO:0030436,GO:0030447,GO:0030448,GO:0030638,GO:0030639,GO:0031160,GO:0032465,GO:0032467,GO:0032502,GO:0032506,GO:0032989,GO:0032991,GO:0040007,GO:0042180,GO:0042181,GO:0042221,GO:0042244,GO:0042546,GO:0043436,GO:0043648,GO:0043650,GO:0043934,GO:0043936,GO:0044085,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044457,GO:0044464,GO:0044550,GO:0045229,GO:0045787,GO:0046189,GO:0046394,GO:0046483,GO:0048518,GO:0048522,GO:0048646,GO:0048856,GO:0048869,GO:0050789,GO:0050794,GO:0050896,GO:0051186,GO:0051188,GO:0051301,GO:0051302,GO:0051716,GO:0051726,GO:0051781,GO:0065007,GO:0070590,GO:0070726,GO:0070887,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0071944,GO:0090068,GO:0090529,GO:1901110,GO:1901112,GO:1901360,GO:1901362,GO:1901576,GO:1901615,GO:1901617,GO:1901661,GO:1901663,GO:1902074,GO:1902075,GO:1903664,GO:1903666,GO:1990586,GO:2000241,GO:2000243,GO:2000244,GO:2000246	-	-	-	-	-	-	-	-	-	-	SsgA
HKD2_k127_4197360_5	1035308.AQYY01000002_gene533	7.45e-76	286.0	COG1228@1|root,COG1228@2|Bacteria,1TP2J@1239|Firmicutes,24AGR@186801|Clostridia,260J1@186807|Peptococcaceae	186801|Clostridia	Q	PFAM Amidohydrolase family	hutI	-	3.5.2.7	ko:K01468	ko00340,ko01100,map00340,map01100	M00045	R02288	RC00683	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1,Amidohydro_3
HKD2_k127_4197360_1	479434.Sthe_1107	1.222e-230	736.0	COG2987@1|root,COG2987@2|Bacteria,2G5PQ@200795|Chloroflexi,27Z10@189775|Thermomicrobia	189775|Thermomicrobia	E	Urocanase C-terminal domain	-	-	4.2.1.49	ko:K01712	ko00340,ko01100,map00340,map01100	M00045	R02914	RC00804	ko00000,ko00001,ko00002,ko01000	-	-	-	Urocanase,Urocanase_C,Urocanase_N
HKD2_k127_4197360_2	1449355.JQNR01000005_gene2488	1.499e-131	445.0	COG2986@1|root,COG2986@2|Bacteria,2GJZW@201174|Actinobacteria	201174|Actinobacteria	E	Histidine ammonia-lyase	hutH	-	4.3.1.3	ko:K01745	ko00340,ko01100,map00340,map01100	M00045	R01168	RC00361	ko00000,ko00001,ko00002,ko01000	-	-	-	Lyase_aromatic
HKD2_k127_4197360_4	471853.Bcav_1835	2.709e-86	297.0	COG0010@1|root,COG0010@2|Bacteria,2GJA6@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the arginase family	-	-	3.5.3.11,3.5.3.8	ko:K01479,ko:K01480	ko00330,ko00340,ko01100,map00330,map00340,map01100	M00045,M00133	R01157,R02285	RC00024,RC00221,RC00329,RC00681	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
HKD2_k127_4197360_10	1118058.CAGY01000001_gene149	1.181e-09	61.0	2ASDQ@1|root,31HT6@2|Bacteria,2HMBW@201174|Actinobacteria,4D6R3@85005|Actinomycetales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4197360_8	479431.Namu_1942	5.743e-17	96.0	COG1396@1|root,COG1396@2|Bacteria	2|Bacteria	K	sequence-specific DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3,HTH_31,HTH_37
HKD2_k127_4197360_7	106370.Francci3_1727	1.099e-38	149.0	COG2801@1|root,COG2801@2|Bacteria,2GKW1@201174|Actinobacteria,4EUWJ@85013|Frankiales	201174|Actinobacteria	L	PFAM Integrase catalytic region	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve
HKD2_k127_4197360_9	1192034.CAP_0421	1.686e-15	85.0	2EPAY@1|root,33GXQ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4211243_1	298654.FraEuI1c_6083	1.068e-164	526.0	COG0463@1|root,COG0463@2|Bacteria,2I568@201174|Actinobacteria,4ESA2@85013|Frankiales	201174|Actinobacteria	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HKD2_k127_4211243_3	326424.FRAAL1249	1.269e-161	516.0	COG0438@1|root,COG0438@2|Bacteria,2GX8V@201174|Actinobacteria,4EWZB@85013|Frankiales	201174|Actinobacteria	M	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
HKD2_k127_4211243_6	479432.Sros_1371	1.76e-101	336.0	COG0500@1|root,COG2226@2|Bacteria,2I0YA@201174|Actinobacteria,4EHJW@85012|Streptosporangiales	201174|Actinobacteria	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
HKD2_k127_4211243_4	656024.FsymDg_1069	1.379e-138	454.0	COG0438@1|root,COG0438@2|Bacteria,2GMEW@201174|Actinobacteria,4ETXA@85013|Frankiales	201174|Actinobacteria	M	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
HKD2_k127_4211243_0	298653.Franean1_5878	7.38e-205	646.0	COG0438@1|root,COG0438@2|Bacteria,2GK9J@201174|Actinobacteria,4ERYI@85013|Frankiales	201174|Actinobacteria	M	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
HKD2_k127_4211243_5	106370.Francci3_0736	1.335e-119	393.0	COG1216@1|root,COG1216@2|Bacteria,2GIUN@201174|Actinobacteria,4ERBZ@85013|Frankiales	201174|Actinobacteria	S	PFAM Glycosyl transferase family 2	wbbL	GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0005976,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044464,GO:0045226,GO:0046379,GO:0071704,GO:0071944,GO:1901576	2.4.1.289	ko:K16870	-	-	-	-	ko00000,ko01000,ko01003	-	-	iNJ661.Rv3265c	Glyco_tranf_2_3,Glycos_transf_2
HKD2_k127_4211243_2	656024.FsymDg_1074	2.322e-163	536.0	COG1208@1|root,COG1208@2|Bacteria,2GKTE@201174|Actinobacteria,4ERNP@85013|Frankiales	201174|Actinobacteria	M	Nucleotidyl transferase	manC	-	2.7.7.13	ko:K00966	ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110	M00114,M00361,M00362	R00885	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase
HKD2_k127_4220952_1	106370.Francci3_0513	3.447e-124	404.0	COG0755@1|root,COG0755@2|Bacteria,2GJR1@201174|Actinobacteria,4ESE9@85013|Frankiales	201174|Actinobacteria	O	Cytochrome c-type biogenesis protein	ccsB	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C_asm
HKD2_k127_4220952_4	870187.Thini_1711	5.001e-50	182.0	COG1848@1|root,COG1848@2|Bacteria,1N8VX@1224|Proteobacteria,1SP0Z@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	-	-	-	-	-	-	-	-	-	PIN
HKD2_k127_4220952_6	446466.Cfla_2943	1.066e-14	76.0	COG3905@1|root,COG3905@2|Bacteria,2GWKG@201174|Actinobacteria	201174|Actinobacteria	K	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source	vapB43	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040008,GO:0044464,GO:0045927,GO:0048518,GO:0050789,GO:0065007,GO:0071944	-	-	-	-	-	-	-	-	-	-	RHH_1
HKD2_k127_4220952_5	28444.JODQ01000014_gene6704	1.156e-15	84.0	2EGDD@1|root,33A58@2|Bacteria,2GR3X@201174|Actinobacteria,4EKHR@85012|Streptosporangiales	201174|Actinobacteria	S	Phospholipase_D-nuclease N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	PLDc_N
HKD2_k127_4220952_0	656024.FsymDg_4029	1.89e-291	899.0	COG0043@1|root,COG0043@2|Bacteria,2GKSI@201174|Actinobacteria,4ET6B@85013|Frankiales	201174|Actinobacteria	H	Belongs to the UbiD family	ubiD	-	4.1.1.98	ko:K03182	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04985,R04986	RC00391	ko00000,ko00001,ko00002,ko01000	-	-	-	UbiD
HKD2_k127_4220952_2	710111.FraQA3DRAFT_3951	1.241e-119	396.0	COG0382@1|root,COG0382@2|Bacteria,2GJJ7@201174|Actinobacteria,4EUMG@85013|Frankiales	201174|Actinobacteria	H	PFAM UbiA prenyltransferase	ubiA	-	2.5.1.39	ko:K03179	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R05000,R05615	RC00209,RC02895	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
HKD2_k127_4220952_3	656024.FsymDg_4027	2.797e-94	314.0	COG0163@1|root,COG0163@2|Bacteria,2GKID@201174|Actinobacteria,4ETA9@85013|Frankiales	201174|Actinobacteria	H	Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN	ubiX	GO:0003674,GO:0003824,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0044237,GO:0044249,GO:0051186,GO:0051188	2.5.1.129	ko:K03186	ko00130,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00627,map00940,map01100,map01110,map01120,map01220	M00117	R01238,R02952,R03367,R04985,R04986,R11225	RC00391,RC00814,RC03392	ko00000,ko00001,ko00002,ko01000	-	-	-	Flavoprotein
HKD2_k127_4230816_1	1304865.JAGF01000001_gene965	6.633e-28	116.0	2EG8Z@1|root,33A0S@2|Bacteria,2I8BH@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4230816_3	1123023.JIAI01000008_gene1538	6.35e-16	85.0	COG0454@1|root,COG0456@2|Bacteria,2I3HD@201174|Actinobacteria,4EF8F@85010|Pseudonocardiales	201174|Actinobacteria	K	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	ACT,Acetyltransf_1,Acetyltransf_3
HKD2_k127_4230816_0	1169161.KB897741_gene1901	2.719e-45	171.0	COG0454@1|root,COG0456@2|Bacteria,2GN77@201174|Actinobacteria	201174|Actinobacteria	K	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HKD2_k127_4230816_2	67257.JODR01000009_gene254	3.38e-21	106.0	COG0457@1|root,COG0457@2|Bacteria,2GM6X@201174|Actinobacteria	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
HKD2_k127_4293028_7	47763.JNZA01000010_gene5731	9.054e-42	174.0	COG2244@1|root,COG2244@2|Bacteria,2GMYJ@201174|Actinobacteria	201174|Actinobacteria	G	outer membrane autotransporter barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt,Polysacc_synt_C
HKD2_k127_4293028_8	981369.JQMJ01000004_gene5186	1.063e-37	164.0	COG2244@1|root,COG2244@2|Bacteria,2GMYJ@201174|Actinobacteria,2NM61@228398|Streptacidiphilus	201174|Actinobacteria	S	polysaccharide biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4293028_4	469371.Tbis_1926	3.113e-65	254.0	COG2244@1|root,COG2244@2|Bacteria,2GMYJ@201174|Actinobacteria,4E516@85010|Pseudonocardiales	201174|Actinobacteria	S	polysaccharide biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt,Polysacc_synt_C
HKD2_k127_4293028_6	388467.A19Y_1637	2.024e-50	197.0	COG0438@1|root,COG0438@2|Bacteria,1G3JN@1117|Cyanobacteria,1H700@1150|Oscillatoriales	1117|Cyanobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
HKD2_k127_4293028_5	357808.RoseRS_2383	7.624e-62	238.0	COG1216@1|root,COG1216@2|Bacteria,2GB2A@200795|Chloroflexi,377SM@32061|Chloroflexia	32061|Chloroflexia	S	PFAM glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HKD2_k127_4293028_3	106370.Francci3_1565	2.363e-121	417.0	COG2227@1|root,COG2227@2|Bacteria,2ICWV@201174|Actinobacteria	201174|Actinobacteria	H	C-methyltransferase C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_13,Methyltransf_14,Methyltransf_23
HKD2_k127_4293028_0	222534.KB893670_gene3873	8.92e-170	551.0	COG2227@1|root,COG2227@2|Bacteria,2I37Y@201174|Actinobacteria,4ESBY@85013|Frankiales	201174|Actinobacteria	H	Methyltransferase domain protein	eryBIII	-	-	ko:K12710,ko:K13317	ko00523,ko01130,map00523,map01130	M00795,M00798	R08933,R11020	RC00003,RC01404,RC03148	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_13,Methyltransf_14,Methyltransf_23
HKD2_k127_4293028_2	298653.Franean1_6561	1.015e-123	406.0	COG0451@1|root,COG0451@2|Bacteria,2GNYX@201174|Actinobacteria,4ETSW@85013|Frankiales	201174|Actinobacteria	M	PFAM NAD-dependent epimerase dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
HKD2_k127_4293028_9	106370.Francci3_1564	2.71e-12	74.0	COG0451@1|root,COG0451@2|Bacteria,2GNYX@201174|Actinobacteria,4ETSW@85013|Frankiales	201174|Actinobacteria	M	PFAM NAD-dependent epimerase dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
HKD2_k127_4293028_1	106370.Francci3_1563	3.428e-127	414.0	COG1208@1|root,COG1208@2|Bacteria,2GKHA@201174|Actinobacteria,4ERRZ@85013|Frankiales	201174|Actinobacteria	JM	Glucose-1-phosphate cytidylyltransferase	-	-	2.7.7.33	ko:K00978	ko00500,ko00520,ko01100,map00500,map00520,map01100	-	R00956	RC00002	ko00000,ko00001,ko01000	-	-	-	NTP_transferase
HKD2_k127_4293492_3	298653.Franean1_5660	4.736e-68	247.0	COG1396@1|root,COG1396@2|Bacteria,2GP8T@201174|Actinobacteria	201174|Actinobacteria	K	TRANSCRIPTIONal	-	-	-	-	-	-	-	-	-	-	-	-	HTH_31
HKD2_k127_4293492_2	656024.FsymDg_1232	5.188e-86	292.0	COG1396@1|root,COG1396@2|Bacteria,2GP8T@201174|Actinobacteria	201174|Actinobacteria	K	TRANSCRIPTIONal	-	-	-	-	-	-	-	-	-	-	-	-	HTH_31
HKD2_k127_4293492_1	656024.FsymDg_1231	5.215e-99	339.0	COG1087@1|root,COG1087@2|Bacteria,2IFFP@201174|Actinobacteria,4EX1Y@85013|Frankiales	201174|Actinobacteria	M	PFAM NAD-dependent epimerase dehydratase	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
HKD2_k127_4293492_7	253839.SSNG_05704	2.002e-31	135.0	COG1051@1|root,COG1051@2|Bacteria,2IFGP@201174|Actinobacteria	201174|Actinobacteria	F	Belongs to the Nudix hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
HKD2_k127_4293492_6	1394178.AWOO02000090_gene1118	4.561e-32	133.0	COG0586@1|root,COG0586@2|Bacteria,2HKKQ@201174|Actinobacteria,4EIYT@85012|Streptosporangiales	201174|Actinobacteria	S	SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
HKD2_k127_4293492_5	1306406.ASHX01000002_gene5091	1.92e-32	141.0	COG4828@1|root,COG4828@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF1622)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1622
HKD2_k127_4293492_10	1906.SFRA_11625	2.217e-09	63.0	2DDFZ@1|root,2ZHXJ@2|Bacteria,2GWT3@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF1622
HKD2_k127_4293492_4	96561.Dole_0791	1.202e-60	225.0	COG1237@1|root,COG1237@2|Bacteria,1RIH8@1224|Proteobacteria,42SZM@68525|delta/epsilon subdivisions,2WPQF@28221|Deltaproteobacteria,2MK8C@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Metallo-beta-lactamase superfamily	-	-	2.5.1.105	ko:K06897	ko00790,map00790	-	R10339	RC00121	ko00000,ko00001,ko01000	-	-	-	Lactamase_B
HKD2_k127_4293492_13	656024.FsymDg_1251	3.896e-08	63.0	COG0864@1|root,COG0864@2|Bacteria,2GZCR@201174|Actinobacteria	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	RHH_1
HKD2_k127_4293492_8	419947.MRA_2006	5.559e-27	117.0	COG2337@1|root,COG2337@2|Bacteria,2IQQ9@201174|Actinobacteria	201174|Actinobacteria	L	Toxic component of a toxin-antitoxin (TA) module	-	GO:0003674,GO:0003824,GO:0004518,GO:0004540,GO:0005575,GO:0005576,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016072,GO:0016075,GO:0016787,GO:0016788,GO:0019222,GO:0019439,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0040008,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0045926,GO:0045927,GO:0046483,GO:0046700,GO:0048518,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360,GO:1901361,GO:1901575	-	ko:K07171	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PemK_toxin
HKD2_k127_4293492_11	1120934.KB894408_gene4688	4.561e-09	58.0	COG2337@1|root,COG2337@2|Bacteria,2IQQ9@201174|Actinobacteria	201174|Actinobacteria	L	Toxic component of a toxin-antitoxin (TA) module	-	GO:0003674,GO:0003824,GO:0004518,GO:0004540,GO:0005575,GO:0005576,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016072,GO:0016075,GO:0016787,GO:0016788,GO:0019222,GO:0019439,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0040008,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0045926,GO:0045927,GO:0046483,GO:0046700,GO:0048518,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360,GO:1901361,GO:1901575	-	ko:K07171	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PemK_toxin
HKD2_k127_4293492_0	58123.JOFJ01000014_gene5041	2.4e-250	825.0	COG0474@1|root,COG0474@2|Bacteria,2GJJC@201174|Actinobacteria,4EGTA@85012|Streptosporangiales	201174|Actinobacteria	P	Cation transporter/ATPase, N-terminus	ctpI	GO:0003674,GO:0003824,GO:0005215,GO:0005388,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006816,GO:0008150,GO:0008324,GO:0015075,GO:0015085,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0030312,GO:0031224,GO:0031226,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043492,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0070588,GO:0070838,GO:0071944,GO:0072511,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132	3.6.3.6,3.6.3.8	ko:K01535,ko:K01537,ko:K12955	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.3.2,3.A.3.24,3.A.3.3	-	-	Cation_ATPase_C,E1-E2_ATPase,Hydrolase
HKD2_k127_4293492_9	1000565.METUNv1_00496	9.291e-16	84.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,2VH2F@28216|Betaproteobacteria,2KUDV@206389|Rhodocyclales	206389|Rhodocyclales	P	COG0474 Cation transport ATPase	-	-	-	-	-	-	-	-	-	-	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
HKD2_k127_4339096_9	1122939.ATUD01000001_gene548	2.719e-12	67.0	COG0365@1|root,COG0365@2|Bacteria,2GJSQ@201174|Actinobacteria,4CRGY@84995|Rubrobacteria	84995|Rubrobacteria	I	AMP-binding enzyme C-terminal domain	-	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
HKD2_k127_4339096_6	446466.Cfla_1078	3.323e-23	115.0	COG3209@1|root,COG3209@2|Bacteria	2|Bacteria	M	self proteolysis	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,VCBS
HKD2_k127_4339096_0	1116472.MGMO_118c00100	1.212e-140	460.0	COG3055@1|root,COG3055@2|Bacteria,1QE0Q@1224|Proteobacteria,1S2S0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Domain of unknown function (DUF1929)	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4339096_3	1173027.Mic7113_3146	1.134e-104	366.0	COG2374@1|root,COG2374@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Endonuclease_1,Exo_endo_phos,LTD
HKD2_k127_4339096_2	290397.Adeh_2106	1.005e-112	374.0	COG0053@1|root,COG0053@2|Bacteria,1MUDS@1224|Proteobacteria,42NCJ@68525|delta/epsilon subdivisions,2WM7V@28221|Deltaproteobacteria,2Z1U0@29|Myxococcales	28221|Deltaproteobacteria	P	Dimerisation domain of Zinc Transporter	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,ZT_dimer
HKD2_k127_4339096_10	1120941.AUBL01000034_gene2176	1.32e-05	56.0	COG1848@1|root,COG1848@2|Bacteria,2HMSF@201174|Actinobacteria,4D7GW@85005|Actinomycetales	201174|Actinobacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4339096_11	1032480.MLP_33830	0.0003034	46.0	2DREV@1|root,33BF4@2|Bacteria,2ISW7@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4339096_7	1463864.JOGO01000059_gene3849	1.013e-16	83.0	COG1983@1|root,COG1983@2|Bacteria,2GQG0@201174|Actinobacteria	201174|Actinobacteria	KT	PspC domain protein	pspC1	-	-	ko:K03973	-	-	-	-	ko00000,ko02048,ko03000	-	-	-	PspC
HKD2_k127_4339096_4	1125971.ASJB01000031_gene1266	2.845e-32	132.0	COG1670@1|root,COG1670@2|Bacteria	2|Bacteria	J	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins	mshD	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0008080,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0017076,GO:0030551,GO:0030552,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363	2.3.1.189	ko:K09181,ko:K15520	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_1,Acetyltransf_3,cNMP_binding
HKD2_k127_4339096_8	40571.JOEA01000028_gene5465	2.31e-16	91.0	2BNZV@1|root,32HQ2@2|Bacteria,2H5IX@201174|Actinobacteria,4EB3P@85010|Pseudonocardiales	201174|Actinobacteria	S	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HKD2_k127_4339096_5	710421.Mycch_1770	7.875e-27	123.0	COG1846@1|root,COG1846@2|Bacteria,2IKZU@201174|Actinobacteria,238PY@1762|Mycobacteriaceae	201174|Actinobacteria	K	MarR family	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
HKD2_k127_4339096_1	649831.L083_2761	1.842e-129	419.0	COG3387@1|root,COG3387@2|Bacteria,2GJAD@201174|Actinobacteria,4D8XJ@85008|Micromonosporales	201174|Actinobacteria	G	Glycoside hydrolase 15-related	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_15
HKD2_k127_4368572_0	526225.Gobs_1147	2.049e-132	469.0	COG1752@1|root,COG1752@2|Bacteria,2IB41@201174|Actinobacteria,4EUJE@85013|Frankiales	201174|Actinobacteria	S	Protein of unknown function (DUF3376)	-	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DUF3376,Patatin
HKD2_k127_4368572_1	656024.FsymDg_0999	2.159e-110	392.0	COG0515@1|root,COG3266@1|root,COG0515@2|Bacteria,COG3266@2|Bacteria,2GIV0@201174|Actinobacteria,4ESF5@85013|Frankiales	201174|Actinobacteria	KLT	Serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HKD2_k127_4368572_3	1185876.BN8_06700	7.117e-27	119.0	COG2085@1|root,COG2085@2|Bacteria,4NEC7@976|Bacteroidetes,47QUG@768503|Cytophagia	976|Bacteroidetes	S	NADP oxidoreductase coenzyme F420-dependent	-	-	1.5.1.40	ko:K06988	-	-	-	-	ko00000,ko01000	-	-	-	F420_oxidored
HKD2_k127_4368572_2	1312959.KI914635_gene1745	6.066e-106	355.0	COG0265@1|root,COG0265@2|Bacteria,2GJ96@201174|Actinobacteria,1W7SI@1268|Micrococcaceae	201174|Actinobacteria	O	Domain present in PSD-95, Dlg, and ZO-1/2.	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
HKD2_k127_4421775_8	656024.FsymDg_3632	1.74e-11	64.0	COG0612@1|root,COG0612@2|Bacteria,2GJZ3@201174|Actinobacteria,4ERHK@85013|Frankiales	201174|Actinobacteria	S	Belongs to the peptidase M16 family	pepR	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
HKD2_k127_4421775_3	710111.FraQA3DRAFT_5837	1.86e-115	378.0	COG0289@1|root,COG0289@2|Bacteria,2GM2T@201174|Actinobacteria,4ERHD@85013|Frankiales	201174|Actinobacteria	E	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate	dapB	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008839,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019752,GO:0019877,GO:0030312,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0048037,GO:0050661,GO:0050662,GO:0051287,GO:0055114,GO:0070402,GO:0070404,GO:0071704,GO:0071944,GO:0097159,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.17.1.8	ko:K00215	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R04198,R04199	RC00478	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv2773c	DapB_C,DapB_N
HKD2_k127_4421775_6	105425.BBPL01000027_gene579	6.625e-26	113.0	COG3548@1|root,COG3548@2|Bacteria,2GRE3@201174|Actinobacteria,2NMY2@228398|Streptacidiphilus	201174|Actinobacteria	S	Protein of unknown function (DUF1211)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1211
HKD2_k127_4421775_9	1120948.KB903243_gene2727	1.662e-06	57.0	COG3548@1|root,COG3548@2|Bacteria,2GRE3@201174|Actinobacteria,4E6WF@85010|Pseudonocardiales	201174|Actinobacteria	S	integral membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF1211
HKD2_k127_4421775_4	298653.Franean1_5469	8.458e-60	227.0	COG5587@1|root,COG5587@2|Bacteria,2IJG5@201174|Actinobacteria,4EV7M@85013|Frankiales	201174|Actinobacteria	S	Conserved hypothetical protein (DUF2461)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2461
HKD2_k127_4421775_5	1394178.AWOO02000010_gene4164	2.329e-54	198.0	COG0454@1|root,COG0456@2|Bacteria,2I2XB@201174|Actinobacteria,4EISZ@85012|Streptosporangiales	201174|Actinobacteria	K	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HKD2_k127_4421775_2	390989.JOEG01000008_gene1415	4.528e-129	416.0	COG1351@1|root,COG1351@2|Bacteria,2HCNJ@201174|Actinobacteria,4DBXM@85008|Micromonosporales	201174|Actinobacteria	F	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant	thyX	GO:0000166,GO:0003674,GO:0003824,GO:0004799,GO:0005488,GO:0008150,GO:0008152,GO:0008168,GO:0016740,GO:0016741,GO:0032259,GO:0036094,GO:0040007,GO:0042083,GO:0043167,GO:0043168,GO:0048037,GO:0050660,GO:0050661,GO:0050662,GO:0050797,GO:0070402,GO:0097159,GO:1901265,GO:1901363	2.1.1.148	ko:K03465	ko00240,ko00670,ko01100,map00240,map00670,map01100	-	R06613	RC00022,RC00332	ko00000,ko00001,ko01000	-	-	iNJ661.Rv2754c	Thy1
HKD2_k127_4421775_7	222534.KB893717_gene1977	1.589e-22	99.0	COG2905@1|root,COG2905@2|Bacteria,2GQMA@201174|Actinobacteria,4EX04@85013|Frankiales	201174|Actinobacteria	T	Domain of unknown function (DUF1918)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1918
HKD2_k127_4421775_1	351607.Acel_1503	3.295e-138	449.0	COG0329@1|root,COG0329@2|Bacteria,2GJ34@201174|Actinobacteria,4ERIQ@85013|Frankiales	201174|Actinobacteria	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	dapA	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
HKD2_k127_4421775_0	656024.FsymDg_3622	2.344e-292	920.0	COG0595@1|root,COG0595@2|Bacteria,2GIW7@201174|Actinobacteria,4ERJT@85013|Frankiales	201174|Actinobacteria	S	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay	rnj	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004527,GO:0004532,GO:0004534,GO:0004540,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008409,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0022613,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0090503,GO:0140098,GO:1901360	-	ko:K12574	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	Lactamase_B,Lactamase_B_2,RMMBL
HKD2_k127_442995_3	561175.KB894104_gene1197	2.309e-14	81.0	COG1126@1|root,COG1126@2|Bacteria,2GIZW@201174|Actinobacteria,4EHV2@85012|Streptosporangiales	201174|Actinobacteria	E	ATPases associated with a variety of cellular activities	atrC	-	3.6.3.21	ko:K02028	-	M00236	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.3	-	-	ABC_tran
HKD2_k127_442995_0	326424.FRAAL5987	1.389e-126	412.0	COG0765@1|root,COG0765@2|Bacteria,2GJJ9@201174|Actinobacteria,4EUII@85013|Frankiales	201174|Actinobacteria	E	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02029	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	BPD_transp_1
HKD2_k127_442995_1	1283299.AUKG01000003_gene319	1.164e-109	363.0	COG0834@1|root,COG0834@2|Bacteria,2GJQW@201174|Actinobacteria,4CQ6I@84995|Rubrobacteria	84995|Rubrobacteria	ET	extracellular solute-binding protein, family 3	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	SBP_bac_3
HKD2_k127_442995_2	298654.FraEuI1c_0819	2.796e-105	353.0	COG0604@1|root,COG0604@2|Bacteria,2GMHR@201174|Actinobacteria,4ES0D@85013|Frankiales	201174|Actinobacteria	C	PFAM Alcohol dehydrogenase, zinc-binding	adh3	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N,ADH_zinc_N_2
HKD2_k127_4441086_2	1120948.KB903228_gene4807	4.443e-92	315.0	COG0615@1|root,COG2870@1|root,COG0615@2|Bacteria,COG2870@2|Bacteria,2GKU1@201174|Actinobacteria,4DYQE@85010|Pseudonocardiales	201174|Actinobacteria	H	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose	hldE	-	-	-	-	-	-	-	-	-	-	-	CTP_transf_like,PfkB
HKD2_k127_4441086_0	1476583.DEIPH_ctg011orf0137	2.733e-119	412.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	rfaG	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glycos_transf_1
HKD2_k127_4441086_1	710111.FraQA3DRAFT_0964	1.13e-106	357.0	COG0859@1|root,COG0859@2|Bacteria,2I90V@201174|Actinobacteria	201174|Actinobacteria	M	Glycosyltransferase family 9 (heptosyltransferase)	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_9
HKD2_k127_4441086_3	1056816.JAFQ01000004_gene3347	2.204e-20	107.0	COG0604@1|root,COG0604@2|Bacteria,2IA9C@201174|Actinobacteria,4G5Z9@85025|Nocardiaceae	201174|Actinobacteria	C	alcohol dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4467080_3	326424.FRAAL0085	2.305e-51	184.0	COG5450@1|root,32SQA@2|Bacteria,2IKJX@201174|Actinobacteria,4ET43@85013|Frankiales	201174|Actinobacteria	K	Transcription regulator of the Arc MetJ class	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4467080_4	106370.Francci3_3063	6.251e-51	190.0	COG1832@1|root,COG1832@2|Bacteria,2IHSP@201174|Actinobacteria	201174|Actinobacteria	S	CoA-binding	-	-	-	ko:K06929	-	-	-	-	ko00000	-	-	-	CoA_binding_2
HKD2_k127_4467080_6	408672.NBCG_00598	6.762e-17	93.0	COG3177@1|root,COG3177@2|Bacteria,2IEWS@201174|Actinobacteria	201174|Actinobacteria	S	Fic/DOC family	-	-	-	-	-	-	-	-	-	-	-	-	Fic
HKD2_k127_4467080_2	671143.DAMO_2638	1.329e-90	308.0	COG3177@1|root,COG3177@2|Bacteria	2|Bacteria	D	Filamentation induced by cAMP protein fic	-	-	-	-	-	-	-	-	-	-	-	-	Fic
HKD2_k127_4467080_0	656024.FsymDg_4454	9.441e-137	455.0	COG1276@1|root,COG2372@1|root,COG1276@2|Bacteria,COG2372@2|Bacteria,2GMKG@201174|Actinobacteria,4ESVK@85013|Frankiales	201174|Actinobacteria	P	Copper resistance protein CopC	-	-	-	ko:K14166	-	-	-	-	ko00000,ko02000	-	-	-	CopC,CopD
HKD2_k127_4467080_5	37919.EP51_05735	2.271e-22	113.0	COG4315@1|root,COG4315@2|Bacteria,2GNDV@201174|Actinobacteria,4G0S9@85025|Nocardiaceae	201174|Actinobacteria	S	Secreted repeat of unknown function	-	-	-	-	-	-	-	-	-	-	-	-	Lipoprotein_15
HKD2_k127_4467080_1	326424.FRAAL0094	9.311e-119	404.0	COG0265@1|root,COG0265@2|Bacteria,2GJ96@201174|Actinobacteria,4ESFY@85013|Frankiales	201174|Actinobacteria	O	peptidase S1 and S6, chymotrypsin Hap	-	-	-	ko:K08372	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ_2,Trypsin_2
HKD2_k127_4467333_8	656024.FsymDg_0507	2.171e-65	225.0	COG1131@1|root,COG1131@2|Bacteria,2GIY8@201174|Actinobacteria,4ERP0@85013|Frankiales	201174|Actinobacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990,ko:K09695	ko02010,map02010	M00252,M00254	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.102	-	-	ABC_tran
HKD2_k127_4467333_4	656024.FsymDg_0506	4.069e-137	446.0	COG0842@1|root,COG0842@2|Bacteria,2GVC2@201174|Actinobacteria,4ESWF@85013|Frankiales	201174|Actinobacteria	V	Transport permease protein	-	-	-	ko:K09694	ko02010,map02010	M00252	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.102	-	-	ABC2_membrane
HKD2_k127_4467333_12	266117.Rxyl_0427	9.441e-37	152.0	COG5486@1|root,COG5486@2|Bacteria,2IAYZ@201174|Actinobacteria,4CTJ6@84995|Rubrobacteria	84995|Rubrobacteria	S	Predicted metal-binding integral membrane protein (DUF2182)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2182
HKD2_k127_4467333_13	446470.Snas_6343	8.688e-31	131.0	COG5588@1|root,COG5588@2|Bacteria,2HIPH@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF1326)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1326
HKD2_k127_4467333_7	656024.FsymDg_4455	3.084e-79	289.0	2DE9Z@1|root,32U2Z@2|Bacteria,2ID6V@201174|Actinobacteria,4EW0B@85013|Frankiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4467333_9	1246995.AFR_20340	2.877e-59	216.0	COG4549@1|root,COG4549@2|Bacteria,2GN9H@201174|Actinobacteria,4DBFT@85008|Micromonosporales	201174|Actinobacteria	S	Domain of unkown function (DUF1775)	-	-	-	ko:K07040	-	-	-	-	ko00000	-	-	-	DUF1775
HKD2_k127_4467333_16	68194.JNXR01000015_gene7877	8.157e-16	85.0	2F664@1|root,31K6H@2|Bacteria,2IDIW@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4467333_6	446462.Amir_1304	6.001e-131	430.0	COG3288@1|root,COG3288@2|Bacteria,2I2FZ@201174|Actinobacteria,4DX8X@85010|Pseudonocardiales	201174|Actinobacteria	C	NAD NADP transhydrogenase alpha subunit	pntAA	-	1.6.1.2	ko:K00324	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
HKD2_k127_4467333_14	1122138.AQUZ01000021_gene8593	2.005e-27	131.0	COG3288@1|root,COG3288@2|Bacteria,2IKR9@201174|Actinobacteria,4DRSV@85009|Propionibacteriales	201174|Actinobacteria	C	4TM region of pyridine nucleotide transhydrogenase, mitoch	pntAB	-	1.6.1.2	ko:K00324	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	PNTB_4TM
HKD2_k127_4467333_2	351607.Acel_2020	2.35e-175	567.0	COG1282@1|root,COG1282@2|Bacteria,2GNKB@201174|Actinobacteria,4ERWF@85013|Frankiales	201174|Actinobacteria	C	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane	pntB	-	1.6.1.2	ko:K00325	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	PNTB
HKD2_k127_4467333_1	710685.MycrhN_0029	1.803e-285	884.0	COG0493@1|root,COG0493@2|Bacteria,2GJ0A@201174|Actinobacteria,236N6@1762|Mycobacteriaceae	201174|Actinobacteria	C	glutamate synthase	preT	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_20,Pyr_redox_2,Pyr_redox_3
HKD2_k127_4467333_0	1240349.ANGC01000003_gene1943	0.0	1867.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1145@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1145@2|Bacteria,2I995@201174|Actinobacteria,4G5GR@85025|Nocardiaceae	201174|Actinobacteria	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	nifJ	-	1.2.7.1	ko:K03737	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00173,M00307	R01196,R10866	RC00004,RC02742	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	EKR,Fer4,PFOR_II,POR,POR_N,TPP_enzyme_C
HKD2_k127_4467333_5	1385519.N801_10425	1.114e-134	447.0	COG0167@1|root,COG0167@2|Bacteria,2GN1V@201174|Actinobacteria,4FIBC@85021|Intrasporangiaceae	201174|Actinobacteria	F	Catalyzes the conversion of dihydroorotate to orotate	-	-	1.3.98.1	ko:K00226	ko00240,ko01100,map00240,map01100	M00051	R01867	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
HKD2_k127_4467333_3	1380390.JIAT01000009_gene2103	7.813e-157	522.0	COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria,4CRJZ@84995|Rubrobacteria	84995|Rubrobacteria	IQ	AMP-binding enzyme C-terminal domain	-	-	-	ko:K12429	-	-	-	-	ko00000,ko01004	-	-	-	AMP-binding,AMP-binding_C
HKD2_k127_4467333_11	47716.JOFH01000007_gene1490	5.226e-45	169.0	COG4636@1|root,COG4636@2|Bacteria,2IHIH@201174|Actinobacteria	201174|Actinobacteria	S	Putative restriction endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	Uma2
HKD2_k127_4467333_17	1214242.B446_12645	2.322e-06	53.0	COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria	201174|Actinobacteria	IQ	PFAM AMP-dependent synthetase and ligase	fadD36	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0042579,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464,GO:0051087	-	ko:K12429,ko:K18662	ko00280,map00280	-	R03383	RC00004,RC00137	ko00000,ko00001,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
HKD2_k127_4467333_15	526225.Gobs_3696	3.629e-22	100.0	COG4691@1|root,COG4691@2|Bacteria,2GX01@201174|Actinobacteria,4EWPU@85013|Frankiales	201174|Actinobacteria	S	Arc-like DNA binding domain	-	-	-	ko:K21495	-	-	-	-	ko00000,ko02048	-	-	-	Arc
HKD2_k127_4467333_10	1121924.ATWH01000006_gene1892	7.842e-50	180.0	COG1487@1|root,COG1487@2|Bacteria,2IS29@201174|Actinobacteria,4FQ1A@85023|Microbacteriaceae	201174|Actinobacteria	S	PIN domain	vapC	-	-	ko:K07062	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PIN
HKD2_k127_4483672_17	1463900.JOIX01000018_gene154	7.478e-27	116.0	28YV2@1|root,2ZKNA@2|Bacteria,2GUI4@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4483672_25	1283283.ATXA01000019_gene2935	2.097e-13	75.0	293DY@1|root,2ZQWC@2|Bacteria,2GWIR@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF1778)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1778
HKD2_k127_4483672_12	1283283.ATXA01000019_gene2936	1.87e-45	169.0	COG0454@1|root,COG0454@2|Bacteria,2IC6K@201174|Actinobacteria	201174|Actinobacteria	K	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10,Acetyltransf_7
HKD2_k127_4483672_28	656024.FsymDg_0787	2.421e-07	59.0	COG0225@1|root,COG0225@2|Bacteria,2GJ1S@201174|Actinobacteria,4ESDQ@85013|Frankiales	201174|Actinobacteria	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	msrA	-	1.8.4.11	ko:K07304	-	-	-	-	ko00000,ko01000	-	-	-	PMSR
HKD2_k127_4483672_19	1121877.JQKF01000043_gene1157	1.147e-23	102.0	COG1669@1|root,COG1669@2|Bacteria,2HGH2@201174|Actinobacteria,4CNEF@84992|Acidimicrobiia	84992|Acidimicrobiia	K	Nucleotidyltransferase domain	-	-	-	ko:K07075	-	-	-	-	ko00000	-	-	-	NTP_transf_2
HKD2_k127_4483672_27	1089546.AQUI01000002_gene4085	1.461e-10	66.0	2DW78@1|root,33YVB@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4483672_24	570268.ANBB01000044_gene1819	1.628e-18	93.0	2DG96@1|root,2ZV05@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4483672_14	326424.FRAAL0365	6.938e-36	142.0	COG2261@1|root,COG2261@2|Bacteria	2|Bacteria	S	Transglycosylase associated protein	-	-	-	-	-	-	-	-	-	-	-	-	Transgly_assoc
HKD2_k127_4483672_2	1122611.KB903985_gene3801	3.884e-201	636.0	COG1804@1|root,COG1804@2|Bacteria,2GIU7@201174|Actinobacteria,4EIA0@85012|Streptosporangiales	201174|Actinobacteria	C	CoA-transferase family III	-	-	2.8.3.16,2.8.3.20	ko:K07749,ko:K18313	-	-	R10640,R10641	RC00014	ko00000,ko01000	-	-	-	CoA_transf_3
HKD2_k127_4483672_1	298654.FraEuI1c_0689	8.891e-207	649.0	COG1249@1|root,COG1249@2|Bacteria,2GPG1@201174|Actinobacteria,4EU8T@85013|Frankiales	201174|Actinobacteria	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation	sthA	-	1.6.1.1	ko:K00322	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_dim
HKD2_k127_4483672_13	656024.FsymDg_0799	4.406e-37	142.0	COG1249@1|root,COG1249@2|Bacteria,2GPG1@201174|Actinobacteria,4EU8T@85013|Frankiales	201174|Actinobacteria	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation	sthA	-	1.6.1.1	ko:K00322	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_dim
HKD2_k127_4483672_8	1114959.SZMC14600_14210	4.556e-55	206.0	COG1192@1|root,COG1192@2|Bacteria,2H4UC@201174|Actinobacteria,4DZB6@85010|Pseudonocardiales	201174|Actinobacteria	D	involved in chromosome partitioning	-	-	-	-	-	-	-	-	-	-	-	-	AAA_31
HKD2_k127_4483672_23	330084.JNYZ01000030_gene187	1.191e-18	94.0	COG5662@1|root,COG5662@2|Bacteria,2HG2K@201174|Actinobacteria,4E2QA@85010|Pseudonocardiales	201174|Actinobacteria	K	AntiSigma factor	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	zf-HC2
HKD2_k127_4483672_11	35754.JNYJ01000036_gene3774	1.089e-48	185.0	COG1595@1|root,COG1595@2|Bacteria,2GM3E@201174|Actinobacteria,4DAU0@85008|Micromonosporales	201174|Actinobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	sigL	GO:0000988,GO:0000990,GO:0003674,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0016987,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0043254,GO:0044087,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1903506,GO:2000112,GO:2000142,GO:2001141	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
HKD2_k127_4483672_20	222534.KB893746_gene2697	3.181e-21	99.0	COG3794@1|root,COG3794@2|Bacteria	2|Bacteria	C	PFAM blue (type 1) copper domain protein	-	-	1.7.2.1	ko:K00368	ko00910,ko01120,map00910,map01120	M00529	R00783,R00785	RC00086	ko00000,ko00001,ko00002,ko01000	-	-	-	Copper-bind,Cu-oxidase_2,Cu-oxidase_3,Cupredoxin_1
HKD2_k127_4483672_0	656024.FsymDg_0800	1.235e-251	794.0	COG0114@1|root,COG0114@2|Bacteria,2GKWY@201174|Actinobacteria,4ERVS@85013|Frankiales	201174|Actinobacteria	C	Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate	fumC	GO:0003674,GO:0003824,GO:0004333,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006106,GO:0006108,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019752,GO:0030312,GO:0040007,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0055114,GO:0071704,GO:0071944,GO:0072350	4.2.1.2	ko:K01679	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211	M00009,M00011,M00173,M00376	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	FumaraseC_C,Lyase_1
HKD2_k127_4483672_9	326424.FRAAL2404	1.905e-54	210.0	COG4758@1|root,COG4758@2|Bacteria,2I8FE@201174|Actinobacteria,4EW3Y@85013|Frankiales	201174|Actinobacteria	S	Cell wall-active antibiotics response 4TMS YvqF	-	-	-	-	-	-	-	-	-	-	-	-	DUF1707,DUF2154
HKD2_k127_4483672_4	710111.FraQA3DRAFT_5485	6.105e-175	568.0	COG1494@1|root,COG1494@2|Bacteria,2GMQU@201174|Actinobacteria,4ES1D@85013|Frankiales	201174|Actinobacteria	G	TIGRFAM fructose-1,6-bisphosphatase, class II	glpX	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006094,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0019318,GO:0019319,GO:0019637,GO:0030145,GO:0030388,GO:0042132,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046364,GO:0046872,GO:0046914,GO:0050308,GO:0071704,GO:1901135,GO:1901576	3.1.3.11	ko:K02446	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200	M00003,M00165,M00167	R00762,R04780	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FBPase_glpX
HKD2_k127_4483672_22	471852.Tcur_1086	5.891e-19	92.0	COG1309@1|root,COG1309@2|Bacteria,2IBVF@201174|Actinobacteria,4EINM@85012|Streptosporangiales	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
HKD2_k127_4483672_15	1449353.JQMQ01000004_gene6256	1.37e-31	127.0	COG1309@1|root,COG1309@2|Bacteria,2IBVF@201174|Actinobacteria	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
HKD2_k127_4483672_10	656024.FsymDg_0805	8.656e-49	192.0	2EID2@1|root,33C4E@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF4245)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4245
HKD2_k127_4483672_21	591157.SSLG_02036	5.435e-19	88.0	COG1722@1|root,COG1722@2|Bacteria,2GR0U@201174|Actinobacteria	201174|Actinobacteria	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseB	-	3.1.11.6	ko:K03602	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_S
HKD2_k127_4483672_18	457429.ABJI02000557_gene5753	6.691e-25	110.0	COG0454@1|root,COG0456@2|Bacteria,2IHU4@201174|Actinobacteria	201174|Actinobacteria	K	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HKD2_k127_4483672_3	222534.KB893670_gene3754	1.356e-181	576.0	COG1570@1|root,COG1570@2|Bacteria,2GJAS@201174|Actinobacteria,4ERQB@85013|Frankiales	201174|Actinobacteria	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseA	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	3.1.11.6	ko:K03601	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_L,tRNA_anti_2
HKD2_k127_4483672_26	526225.Gobs_3419	2.659e-11	74.0	2CFK1@1|root,334PB@2|Bacteria,2GQPZ@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4483672_5	106370.Francci3_3881	2.845e-165	524.0	COG0761@1|root,COG0761@2|Bacteria,2GIZ7@201174|Actinobacteria,4ES7R@85013|Frankiales	201174|Actinobacteria	IM	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis	ispH	-	1.17.7.4	ko:K03527	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05884,R08210	RC01137,RC01487	ko00000,ko00001,ko00002,ko01000	-	-	-	LYTB
HKD2_k127_4483672_6	326424.FRAAL6141	1.644e-161	523.0	COG1322@1|root,COG1322@2|Bacteria,2GP4U@201174|Actinobacteria,4ERYH@85013|Frankiales	201174|Actinobacteria	S	RmuC family	rmuC	-	-	ko:K09760	-	-	-	-	ko00000	-	-	-	RmuC
HKD2_k127_4483672_7	656024.FsymDg_0828	3.681e-142	467.0	COG0012@1|root,COG0012@2|Bacteria,2GIXI@201174|Actinobacteria,4ES8Y@85013|Frankiales	201174|Actinobacteria	J	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner	ychF	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,YchF-GTPase_C
HKD2_k127_4483726_1	1246995.AFR_27945	1.089e-154	514.0	COG1510@1|root,COG3276@1|root,COG1510@2|Bacteria,COG3276@2|Bacteria,2GKF9@201174|Actinobacteria,4DBVC@85008|Micromonosporales	201174|Actinobacteria	J	Selenocysteine-specific translation elongation factor	selB	-	-	ko:K03833	-	-	-	-	ko00000,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,SelB-wing_2,SelB-wing_3
HKD2_k127_4483726_0	1386089.N865_14365	1.876e-160	516.0	COG1921@1|root,COG1921@2|Bacteria,2HFGK@201174|Actinobacteria,4FG08@85021|Intrasporangiaceae	201174|Actinobacteria	E	L-seryl-tRNA selenium transferase	selA	-	2.9.1.1	ko:K01042	ko00450,ko00970,map00450,map00970	-	R08219	RC01246	ko00000,ko00001,ko01000	-	-	-	Se-cys_synth_N,SelA
HKD2_k127_4483726_4	1304878.AUGD01000013_gene2911	1.162e-13	72.0	2DCCS@1|root,2ZDPW@2|Bacteria,1R18M@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4483726_2	1125971.ASJB01000031_gene1241	2.459e-70	248.0	COG3409@1|root,COG3409@2|Bacteria,2HUBB@201174|Actinobacteria,4E7IY@85010|Pseudonocardiales	201174|Actinobacteria	M	Peptidoglycan-binding domain 1 protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4483866_5	1122138.AQUZ01000068_gene2434	1.099e-31	131.0	COG0477@1|root,COG2814@2|Bacteria,2HCHA@201174|Actinobacteria,4DUH6@85009|Propionibacteriales	201174|Actinobacteria	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_2
HKD2_k127_4483866_0	656024.FsymDg_0273	1.111e-237	744.0	COG0034@1|root,COG0034@2|Bacteria,2GK6I@201174|Actinobacteria,4ERIS@85013|Frankiales	201174|Actinobacteria	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	GO:0008150,GO:0040007	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_6,GATase_7,Pribosyltran
HKD2_k127_4483866_2	351607.Acel_2071	1.812e-136	456.0	COG0150@1|root,COG0150@2|Bacteria,2GJNY@201174|Actinobacteria,4ERKV@85013|Frankiales	201174|Actinobacteria	F	PFAM AIR synthase related protein	purM	-	6.3.3.1	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04208	RC01100	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
HKD2_k127_4483866_1	656024.FsymDg_0275	6.129e-195	636.0	COG2203@1|root,COG5001@1|root,COG2203@2|Bacteria,COG5001@2|Bacteria,2GIZF@201174|Actinobacteria,4EUR5@85013|Frankiales	201174|Actinobacteria	T	TIGRFAM Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF
HKD2_k127_4483866_6	298655.KI912266_gene1663	1.435e-11	66.0	COG3547@1|root,COG3547@2|Bacteria,2GS79@201174|Actinobacteria,4ERY8@85013|Frankiales	201174|Actinobacteria	L	PFAM transposase IS116 IS110 IS902 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
HKD2_k127_4483866_4	479431.Namu_2060	3.186e-35	138.0	COG3547@1|root,COG3547@2|Bacteria,2GS79@201174|Actinobacteria,4ERY8@85013|Frankiales	201174|Actinobacteria	L	PFAM transposase IS116 IS110 IS902 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
HKD2_k127_4483866_3	298654.FraEuI1c_7085	9.276e-62	224.0	COG3255@1|root,COG3255@2|Bacteria,2IQBF@201174|Actinobacteria,4ETAU@85013|Frankiales	201174|Actinobacteria	I	Sterol carrier protein	-	-	-	-	-	-	-	-	-	-	-	-	MDMPI_C,MDMPI_N
HKD2_k127_4525616_4	1394178.AWOO02000060_gene544	5.465e-148	492.0	COG1807@1|root,COG1807@2|Bacteria,2GJPU@201174|Actinobacteria,4EIMF@85012|Streptosporangiales	201174|Actinobacteria	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HKD2_k127_4525616_9	1828.JOKB01000041_gene3952	3.187e-95	317.0	COG0745@1|root,COG0745@2|Bacteria,2GIZB@201174|Actinobacteria,4FU16@85025|Nocardiaceae	201174|Actinobacteria	T	Transcriptional regulatory protein, C terminal	mprA	GO:0000160,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006355,GO:0007154,GO:0007165,GO:0008150,GO:0009268,GO:0009628,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010446,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0016020,GO:0019219,GO:0019222,GO:0023052,GO:0030312,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0035556,GO:0043254,GO:0044087,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0090034,GO:0097159,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2001141	-	ko:K07669,ko:K07672	ko02020,map02020	M00460,M00463	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
HKD2_k127_4525616_8	298653.Franean1_5310	4.7e-105	367.0	COG0642@1|root,COG2205@2|Bacteria,2GM17@201174|Actinobacteria,4ES13@85013|Frankiales	201174|Actinobacteria	T	signal transduction histidine kinase	-	-	2.7.13.3	ko:K07653	ko02020,map02020	M00460	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
HKD2_k127_4525616_0	351607.Acel_1652	0.0	1052.0	COG2217@1|root,COG2217@2|Bacteria,2GIRF@201174|Actinobacteria,4ERMQ@85013|Frankiales	201174|Actinobacteria	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
HKD2_k127_4525616_16	351607.Acel_1651	3.146e-19	91.0	COG2608@1|root,COG2608@2|Bacteria	2|Bacteria	P	mercury ion transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	HMA
HKD2_k127_4525616_13	351607.Acel_1650	1.251e-34	136.0	COG1937@1|root,COG1937@2|Bacteria,2IQAC@201174|Actinobacteria,4ET9B@85013|Frankiales	201174|Actinobacteria	S	Evidence 2a Function of homologous gene experimentally demonstrated in an other organism	csoR	-	-	ko:K21600	-	-	-	-	ko00000,ko03000	-	-	-	Trns_repr_metal
HKD2_k127_4525616_1	656024.FsymDg_1953	4.882e-249	776.0	COG0069@1|root,COG0069@2|Bacteria,2GME2@201174|Actinobacteria,4ESBJ@85013|Frankiales	201174|Actinobacteria	E	Belongs to the glutamate synthase family	gltB_1	-	1.4.7.1	ko:K00284	ko00630,ko00910,ko01120,map00630,map00910,map01120	-	R00021,R10086	RC00006,RC00010	ko00000,ko00001,ko01000	-	-	-	Glu_synthase
HKD2_k127_4525616_11	351607.Acel_0525	1.284e-47	174.0	COG2210@1|root,COG2210@2|Bacteria,2IFXH@201174|Actinobacteria,4EWZZ@85013|Frankiales	201174|Actinobacteria	S	DsrE/DsrF/DrsH-like family	-	-	-	-	-	-	-	-	-	-	-	-	DrsE_2
HKD2_k127_4525616_14	351607.Acel_0524	7.961e-34	134.0	COG0425@1|root,COG0425@2|Bacteria	2|Bacteria	O	sulfur carrier activity	-	-	-	-	-	-	-	-	-	-	-	-	TusA
HKD2_k127_4525616_5	351607.Acel_0523	1.154e-142	467.0	COG0446@1|root,COG0446@2|Bacteria,2GRTN@201174|Actinobacteria,4ESWT@85013|Frankiales	201174|Actinobacteria	S	FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.5.4	ko:K17218	ko00920,map00920	-	R10152	RC03155	ko00000,ko00001,ko01000	-	-	-	DsrC,Pyr_redox_2
HKD2_k127_4525616_12	526225.Gobs_4691	7.839e-39	147.0	2FDWQ@1|root,345X5@2|Bacteria,2IR16@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4525616_6	512565.AMIS_32100	9.26e-130	425.0	COG1168@1|root,COG1168@2|Bacteria,2GJFQ@201174|Actinobacteria,4D8FB@85008|Micromonosporales	201174|Actinobacteria	E	Aminotransferase class I and II	-	-	4.4.1.8	ko:K14155	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	-	R00782,R01286,R02408,R04941	RC00056,RC00069,RC00382,RC00488,RC00710,RC01245,RC02303	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
HKD2_k127_4525616_10	298653.Franean1_1853	1.909e-76	263.0	COG0637@1|root,COG0637@2|Bacteria,2I362@201174|Actinobacteria	201174|Actinobacteria	S	hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
HKD2_k127_4525616_2	345341.KUTG_00683	3.939e-200	665.0	COG3292@1|root,COG3386@1|root,COG3292@2|Bacteria,COG3386@2|Bacteria,2IAXB@201174|Actinobacteria,4E9GM@85010|Pseudonocardiales	201174|Actinobacteria	GT	PFAM SMP-30 Gluconolaconase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4525616_7	656024.FsymDg_4351	9.27e-123	397.0	COG3442@1|root,COG3442@2|Bacteria,2GKPV@201174|Actinobacteria,4EVDW@85013|Frankiales	201174|Actinobacteria	H	PFAM CobB CobQ domain protein glutamine amidotransferase	cobQ2	-	-	ko:K07009	-	-	-	-	ko00000	-	-	-	GATase_3
HKD2_k127_4525616_3	222534.KB893750_gene4331	1.058e-197	624.0	COG0771@1|root,COG0771@2|Bacteria,2GK18@201174|Actinobacteria,4EUSE@85013|Frankiales	201174|Actinobacteria	M	Mur ligase middle domain	murE	-	-	-	-	-	-	-	-	-	-	-	DUF1727,Mur_ligase_M
HKD2_k127_4525616_15	1160137.KB907309_gene5481	4.47e-28	129.0	COG0739@1|root,COG0739@2|Bacteria,2GXEC@201174|Actinobacteria,4FYXU@85025|Nocardiaceae	201174|Actinobacteria	M	Peptidase family M23	envC	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
HKD2_k127_4531783_1	710111.FraQA3DRAFT_5921	1.389e-81	297.0	COG2365@1|root,COG2365@2|Bacteria,2GK28@201174|Actinobacteria,4EVXB@85013|Frankiales	201174|Actinobacteria	T	Tyrosine phosphatase family	-	-	3.1.3.48	ko:K01104	-	-	-	-	ko00000,ko01000	-	-	-	Y_phosphatase3
HKD2_k127_4531783_0	351607.Acel_1394	0.0	1264.0	COG1048@1|root,COG1048@2|Bacteria,2GJD5@201174|Actinobacteria,4ESAU@85013|Frankiales	201174|Actinobacteria	C	Aconitate hydratase 1	acnA	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
HKD2_k127_4535363_0	298655.KI912267_gene7567	1.025e-279	871.0	COG0013@1|root,COG0013@2|Bacteria,2GIUG@201174|Actinobacteria,4ERRJ@85013|Frankiales	201174|Actinobacteria	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0030312,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
HKD2_k127_4535363_4	298653.Franean1_1695	1.747e-50	194.0	COG0816@1|root,COG0816@2|Bacteria,2IQB0@201174|Actinobacteria,4ET3K@85013|Frankiales	201174|Actinobacteria	L	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA	ruvX	GO:0000966,GO:0000967,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0040007,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360	-	ko:K07447	-	-	-	-	ko00000,ko01000	-	-	-	RuvX
HKD2_k127_4535363_2	656024.FsymDg_3330	1.673e-102	356.0	COG1559@1|root,COG1559@2|Bacteria,2GKGQ@201174|Actinobacteria,4ESC2@85013|Frankiales	201174|Actinobacteria	S	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation	mltG	-	-	ko:K07082	-	-	-	-	ko00000	-	-	-	YceG
HKD2_k127_4535363_3	298653.Franean1_1697	4.423e-78	288.0	COG0169@1|root,COG0169@2|Bacteria,2GPQQ@201174|Actinobacteria,4ESSI@85013|Frankiales	201174|Actinobacteria	E	Shikimate dehydrogenase	aroE	GO:0000166,GO:0003674,GO:0003824,GO:0004764,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019632,GO:0019752,GO:0032787,GO:0036094,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0097159,GO:1901265,GO:1901363,GO:1901576,GO:1901615	1.1.1.25	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413	RC00206	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv2552c	Shikimate_DH,Shikimate_dh_N
HKD2_k127_4535363_6	298655.KI912267_gene7563	1.013e-38	162.0	COG1989@1|root,COG1989@2|Bacteria	2|Bacteria	NOU	aspartic-type endopeptidase activity	pppA	-	3.4.23.43	ko:K02654	-	M00331	-	-	ko00000,ko00002,ko01000,ko01002,ko02035,ko02044	3.A.15.2	-	-	DiS_P_DiS,Peptidase_A24
HKD2_k127_4535363_1	298653.Franean1_1699	4.551e-191	616.0	COG0082@1|root,COG0082@2|Bacteria,2GJJN@201174|Actinobacteria,4ES2K@85013|Frankiales	201174|Actinobacteria	E	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system	aroC	GO:0000166,GO:0003674,GO:0003824,GO:0004107,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0010181,GO:0016053,GO:0016491,GO:0016651,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0032553,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	4.2.3.5	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01714	RC00586	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv2540c	Chorismate_synt
HKD2_k127_4535363_5	68170.KL590474_gene5714	8.727e-39	164.0	COG4636@1|root,COG4636@2|Bacteria,2IGTR@201174|Actinobacteria,4E2US@85010|Pseudonocardiales	201174|Actinobacteria	S	Putative restriction endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	Uma2
HKD2_k127_4545539_0	351607.Acel_1127	0.0	1073.0	COG0021@1|root,COG0021@2|Bacteria,2GJ1K@201174|Actinobacteria,4ERGD@85013|Frankiales	201174|Actinobacteria	G	Belongs to the transketolase family	tkt	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
HKD2_k127_4613689_3	886293.Sinac_5610	1.441e-31	134.0	COG2170@1|root,COG2170@2|Bacteria,2IXAU@203682|Planctomycetes	203682|Planctomycetes	H	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity	-	-	-	ko:K06048	-	-	-	-	ko00000,ko01000	-	-	-	GCS2
HKD2_k127_4613689_2	103733.JNYO01000013_gene4313	2.141e-118	388.0	COG1946@1|root,COG1946@2|Bacteria,2GJ1B@201174|Actinobacteria,4DX4D@85010|Pseudonocardiales	201174|Actinobacteria	I	Acyl-CoA thioesterase	tesB	-	-	ko:K10805	ko01040,map01040	-	-	-	ko00000,ko00001,ko01000,ko01004	-	-	-	4HBT_3
HKD2_k127_4613689_0	1123024.AUII01000025_gene2139	2.564e-276	874.0	COG0474@1|root,COG0474@2|Bacteria,2GJJC@201174|Actinobacteria,4E15N@85010|Pseudonocardiales	201174|Actinobacteria	P	E1-E2 ATPase	ctpE	-	-	ko:K12952	-	-	-	-	ko00000,ko01000	3.A.3.23	-	-	E1-E2_ATPase,Hydrolase
HKD2_k127_4613689_5	1497679.EP56_13535	0.0002385	49.0	COG1396@1|root,COG1396@2|Bacteria,1VXX8@1239|Firmicutes,4HX36@91061|Bacilli	91061|Bacilli	K	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
HKD2_k127_4613689_4	1380347.JNII01000005_gene3460	6.392e-09	69.0	COG1994@1|root,COG1994@2|Bacteria,2HTRB@201174|Actinobacteria,4ETWZ@85013|Frankiales	201174|Actinobacteria	S	Peptidase M50	-	-	-	ko:K16922	-	-	-	-	ko00000,ko01002	-	-	-	-
HKD2_k127_4613689_1	996637.SGM_2641	6.904e-122	408.0	COG1994@1|root,COG1994@2|Bacteria	2|Bacteria	S	metallopeptidase activity	-	-	-	ko:K16922	-	-	-	-	ko00000,ko01002	-	-	-	-
HKD2_k127_4622360_8	459495.SPLC1_S050780	3.141e-10	66.0	COG2402@1|root,COG2402@2|Bacteria,1G5Y8@1117|Cyanobacteria,1HB8Y@1150|Oscillatoriales	1117|Cyanobacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
HKD2_k127_4622360_2	446462.Amir_1281	1.427e-83	288.0	COG0457@1|root,COG1813@1|root,COG0457@2|Bacteria,COG1813@2|Bacteria,2IBWS@201174|Actinobacteria,4E3J8@85010|Pseudonocardiales	201174|Actinobacteria	K	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3,HTH_31
HKD2_k127_4622360_7	446462.Amir_1281	1.789e-17	93.0	COG0457@1|root,COG1813@1|root,COG0457@2|Bacteria,COG1813@2|Bacteria,2IBWS@201174|Actinobacteria,4E3J8@85010|Pseudonocardiales	201174|Actinobacteria	K	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3,HTH_31
HKD2_k127_4622360_5	1056816.JAFQ01000004_gene6263	8.035e-56	199.0	COG1051@1|root,COG1051@2|Bacteria,2IJRD@201174|Actinobacteria,4G0N2@85025|Nocardiaceae	201174|Actinobacteria	F	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
HKD2_k127_4622360_6	446462.Amir_1283	5.266e-49	183.0	COG2175@1|root,COG2175@2|Bacteria,2IH0Q@201174|Actinobacteria,4E7RU@85010|Pseudonocardiales	201174|Actinobacteria	Q	Taurine catabolism dioxygenase TauD, TfdA family	-	-	-	-	-	-	-	-	-	-	-	-	TauD
HKD2_k127_4622360_0	1449347.JQLN01000007_gene1374	3.317e-101	340.0	COG1215@1|root,COG1215@2|Bacteria,2I2NS@201174|Actinobacteria,2M44T@2063|Kitasatospora	201174|Actinobacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HKD2_k127_4622360_3	106370.Francci3_1581	8.003e-83	291.0	COG1216@1|root,COG1216@2|Bacteria,2GKTW@201174|Actinobacteria,4ETWP@85013|Frankiales	201174|Actinobacteria	S	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3,Glyco_transf_7C,Glycos_transf_2
HKD2_k127_4622360_4	106370.Francci3_1581	7.714e-80	291.0	COG1216@1|root,COG1216@2|Bacteria,2GKTW@201174|Actinobacteria,4ETWP@85013|Frankiales	201174|Actinobacteria	S	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3,Glyco_transf_7C,Glycos_transf_2
HKD2_k127_4622360_1	326424.FRAAL6118	4.747e-91	315.0	COG1215@1|root,COG1215@2|Bacteria,2GP1D@201174|Actinobacteria,4ERXB@85013|Frankiales	201174|Actinobacteria	M	glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HKD2_k127_4625275_2	219305.MCAG_01072	3.373e-75	260.0	COG1024@1|root,COG1024@2|Bacteria,2GKC4@201174|Actinobacteria,4D8DY@85008|Micromonosporales	201174|Actinobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	echA	-	-	-	-	-	-	-	-	-	-	-	ECH_1
HKD2_k127_4625275_0	656024.FsymDg_1751	2.55e-304	948.0	COG1132@1|root,COG1132@2|Bacteria,2GITR@201174|Actinobacteria,4ERSA@85013|Frankiales	201174|Actinobacteria	V	ABC transporter, transmembrane region	msbA	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
HKD2_k127_4625275_1	106370.Francci3_1678	1.078e-199	630.0	COG0469@1|root,COG0469@2|Bacteria,2GJY8@201174|Actinobacteria,4ERSJ@85013|Frankiales	201174|Actinobacteria	G	Belongs to the pyruvate kinase family	pyk	GO:0003674,GO:0003824,GO:0004743,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016052,GO:0016053,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0040007,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PK,PK_C
HKD2_k127_4677635_4	298655.KI912266_gene5317	7.433e-59	207.0	COG1385@1|root,COG1385@2|Bacteria,2GTKX@201174|Actinobacteria,4ESIJ@85013|Frankiales	201174|Actinobacteria	J	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit	rsmE	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016436,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070042,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.193	ko:K09761	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_RNA
HKD2_k127_4677635_0	656024.FsymDg_1618	5.794e-187	607.0	COG0484@1|root,COG0484@2|Bacteria,2GK69@201174|Actinobacteria,4ERI5@85013|Frankiales	201174|Actinobacteria	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030312,GO:0040007,GO:0044464,GO:0071944	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
HKD2_k127_4677635_2	656024.FsymDg_1617	1.711e-159	528.0	COG1420@1|root,COG1420@2|Bacteria,2GKF5@201174|Actinobacteria,4ERW7@85013|Frankiales	201174|Actinobacteria	K	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons	hrcA	GO:0005575,GO:0005623,GO:0005886,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016020,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0044464,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141	-	ko:K03705	-	-	-	-	ko00000,ko03000	-	-	-	HTH_DeoR,HrcA
HKD2_k127_4677635_1	656024.FsymDg_1616	4.012e-163	560.0	COG0635@1|root,COG0635@2|Bacteria,2GJXX@201174|Actinobacteria,4ES5C@85013|Frankiales	201174|Actinobacteria	H	Involved in the biosynthesis of porphyrin-containing compound	hemN	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	-	-	-	-	-	-	-	-	-	iNJ661.Rv2388c	HemN_C,Radical_SAM
HKD2_k127_4677635_3	1133850.SHJG_3935	2.079e-110	400.0	COG2378@1|root,COG2378@2|Bacteria,2I8XQ@201174|Actinobacteria	201174|Actinobacteria	K	Helicase conserved C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Helicase_C_3
HKD2_k127_4694925_12	463191.SSEG_11300	8.567e-08	58.0	29TF6@1|root,30ENC@2|Bacteria,2GWRG@201174|Actinobacteria	201174|Actinobacteria	S	F subunit of K+-transporting ATPase (Potass_KdpF)	-	-	-	-	-	-	-	-	-	-	-	-	Potass_KdpF
HKD2_k127_4694925_10	479432.Sros_8771	1.779e-14	85.0	2EIVK@1|root,338C8@2|Bacteria,2I881@201174|Actinobacteria,4EQJ2@85012|Streptosporangiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4694925_6	1463901.JOIY01000028_gene4117	5.717e-45	178.0	COG2091@1|root,COG2091@2|Bacteria,2IQ65@201174|Actinobacteria	201174|Actinobacteria	H	Belongs to the P-Pant transferase superfamily	-	-	-	ko:K06133	ko00770,map00770	-	R01625	RC00002	ko00000,ko00001,ko01000	-	-	-	ACPS
HKD2_k127_4694925_7	103733.JNYO01000025_gene8919	2.059e-34	139.0	COG1280@1|root,COG1280@2|Bacteria,2ICJX@201174|Actinobacteria,4EEZQ@85010|Pseudonocardiales	201174|Actinobacteria	E	LysE type translocator	-	-	-	-	-	-	-	-	-	-	-	-	LysE
HKD2_k127_4694925_1	37919.EP51_35085	5.61e-116	389.0	COG2909@1|root,COG3629@1|root,COG2909@2|Bacteria,COG3629@2|Bacteria,2GJAR@201174|Actinobacteria,4G9JD@85025|Nocardiaceae	201174|Actinobacteria	K	Bacterial transcriptional activator domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,BTAD,Guanylate_cyc,Trans_reg_C
HKD2_k127_4694925_3	37919.EP51_35085	1.369e-104	361.0	COG2909@1|root,COG3629@1|root,COG2909@2|Bacteria,COG3629@2|Bacteria,2GJAR@201174|Actinobacteria,4G9JD@85025|Nocardiaceae	201174|Actinobacteria	K	Bacterial transcriptional activator domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,BTAD,Guanylate_cyc,Trans_reg_C
HKD2_k127_4694925_2	101510.RHA1_ro01557	4.429e-107	363.0	COG2909@1|root,COG3629@1|root,COG2909@2|Bacteria,COG3629@2|Bacteria,2GJAR@201174|Actinobacteria,4G9JD@85025|Nocardiaceae	201174|Actinobacteria	K	Bacterial transcriptional activator domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,BTAD,Guanylate_cyc,Trans_reg_C
HKD2_k127_4694925_0	101510.RHA1_ro01556	1.053e-263	816.0	COG0277@1|root,COG0277@2|Bacteria,2GK5U@201174|Actinobacteria,4FVIP@85025|Nocardiaceae	201174|Actinobacteria	C	FAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	BBE,FAD_binding_4
HKD2_k127_4694925_9	446471.Xcel_1932	6.702e-19	97.0	COG1042@1|root,COG1670@1|root,COG1042@2|Bacteria,COG1670@2|Bacteria,2GKN1@201174|Actinobacteria,4F3M7@85017|Promicromonosporaceae	201174|Actinobacteria	CJ	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig
HKD2_k127_4694925_4	106370.Francci3_0165	2.34e-95	321.0	COG0726@1|root,COG0726@2|Bacteria,2HTZN@201174|Actinobacteria,4EVUG@85013|Frankiales	201174|Actinobacteria	G	Polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
HKD2_k127_4694925_5	469383.Cwoe_1135	4.854e-47	184.0	COG3268@1|root,COG3268@2|Bacteria,2GMKU@201174|Actinobacteria,4CSJP@84995|Rubrobacteria	84995|Rubrobacteria	S	Saccharopine dehydrogenase NADP binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Sacchrp_dh_NADP
HKD2_k127_4694925_8	298655.KI912266_gene2336	7.927e-31	125.0	COG1278@1|root,COG1278@2|Bacteria,2GQRU@201174|Actinobacteria	201174|Actinobacteria	K	Cold shock protein	-	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
HKD2_k127_4694925_11	298653.Franean1_6574	1.79e-10	61.0	COG0136@1|root,COG0136@2|Bacteria,2GJJ8@201174|Actinobacteria,4ERE4@85013|Frankiales	201174|Actinobacteria	E	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate	asd	-	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
HKD2_k127_4695621_0	656024.FsymDg_0739	3.679e-231	754.0	COG0488@1|root,COG0488@2|Bacteria,2GJ5M@201174|Actinobacteria,4ERRQ@85013|Frankiales	201174|Actinobacteria	S	PFAM ABC transporter	yjjK	-	-	ko:K15738	-	-	-	-	ko00000,ko02000	3.A.1.120.6	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
HKD2_k127_4695621_1	656024.FsymDg_0738	1.792e-114	385.0	COG1947@1|root,COG1947@2|Bacteria,2GKXD@201174|Actinobacteria,4ESAI@85013|Frankiales	201174|Actinobacteria	I	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol	ispE	GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0040007,GO:0044237,GO:0050515	2.7.1.148	ko:K00919	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05634	RC00002,RC01439	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
HKD2_k127_4695621_2	222534.KB893670_gene3824	1.053e-50	185.0	COG1302@1|root,COG1302@2|Bacteria,2IMA3@201174|Actinobacteria,4ET0R@85013|Frankiales	201174|Actinobacteria	S	Asp23 family, cell envelope-related function	-	-	-	-	-	-	-	-	-	-	-	-	Asp23
HKD2_k127_4695621_4	164757.Mjls_2271	2.908e-11	74.0	COG1302@1|root,COG1302@2|Bacteria,2GWZ9@201174|Actinobacteria,23BK5@1762|Mycobacteriaceae	201174|Actinobacteria	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4695621_3	326424.FRAAL6272	3.64e-15	82.0	2EGEG@1|root,33A6G@2|Bacteria,2HTM2@201174|Actinobacteria,4ETGX@85013|Frankiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF2273
HKD2_k127_4725571_0	1146883.BLASA_1098	1.426e-93	324.0	COG3385@1|root,COG3385@2|Bacteria,2H68X@201174|Actinobacteria,4EV7U@85013|Frankiales	201174|Actinobacteria	L	Transposase DDE domain group 1	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_4
HKD2_k127_4725571_1	1146883.BLASA_0772	1.444e-63	224.0	COG3385@1|root,COG3385@2|Bacteria,2H68X@201174|Actinobacteria,4EV7U@85013|Frankiales	201174|Actinobacteria	L	Transposase DDE domain group 1	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_4
HKD2_k127_476482_1	656024.FsymDg_4277	7.812e-56	213.0	COG3576@1|root,COG3576@2|Bacteria,2II3S@201174|Actinobacteria,4EWB9@85013|Frankiales	201174|Actinobacteria	S	Pyridoxamine 5'-phosphate	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
HKD2_k127_476482_6	101510.RHA1_ro11204	2.171e-15	89.0	COG2770@1|root,COG5002@1|root,COG2770@2|Bacteria,COG5002@2|Bacteria,2GIX7@201174|Actinobacteria,4G9FM@85025|Nocardiaceae	201174|Actinobacteria	T	His Kinase A (phospho-acceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
HKD2_k127_476482_4	397278.JOJN01000018_gene3506	2.603e-22	98.0	COG1225@1|root,COG1225@2|Bacteria,2IGFI@201174|Actinobacteria,4DRG7@85009|Propionibacteriales	201174|Actinobacteria	O	Redoxin	-	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
HKD2_k127_476482_5	1385519.N801_09840	3.471e-18	87.0	COG3462@1|root,COG3462@2|Bacteria,2HXV6@201174|Actinobacteria,4FHUV@85021|Intrasporangiaceae	201174|Actinobacteria	S	membrane protein (DUF2078)	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_476482_2	290399.Arth_4485	2.751e-42	164.0	COG4454@1|root,COG4454@2|Bacteria,2I9JP@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	SoxE
HKD2_k127_476482_0	1429046.RR21198_4793	0.0	1201.0	COG1012@1|root,COG1454@1|root,COG1012@2|Bacteria,COG1454@2|Bacteria,2GJI2@201174|Actinobacteria,4G9H7@85025|Nocardiaceae	201174|Actinobacteria	C	Aldehyde dehydrogenase family	adhE	-	1.1.1.1,1.2.1.10,1.2.1.81	ko:K04072,ko:K15515	ko00010,ko00071,ko00350,ko00620,ko00625,ko00626,ko00650,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00620,map00625,map00626,map00650,map01100,map01110,map01120,map01130,map01220	-	R00228,R00623,R00754,R01172,R04880,R05233,R05234,R06917,R06927	RC00004,RC00050,RC00088,RC00099,RC00116,RC00184,RC00649,RC01195	ko00000,ko00001,ko01000	-	-	-	Aldedh,Fe-ADH
HKD2_k127_4813418_3	222534.KB893772_gene4626	1.371e-69	241.0	COG0451@1|root,COG0560@1|root,COG0451@2|Bacteria,COG0560@2|Bacteria,2GJVX@201174|Actinobacteria	201174|Actinobacteria	E	HAD-superfamily subfamily IB hydrolase, TIGR01490	-	-	-	-	-	-	-	-	-	-	-	-	HAD,NAD_binding_4,Sterile
HKD2_k127_4813418_1	287986.DV20_10630	1.726e-109	378.0	COG0578@1|root,COG0578@2|Bacteria,2GJKN@201174|Actinobacteria,4DYGV@85010|Pseudonocardiales	201174|Actinobacteria	C	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family	-	-	1.1.5.3	ko:K00111	ko00564,ko01110,map00564,map01110	-	R00848	RC00029	ko00000,ko00001,ko01000	-	-	-	DAO,DAO_C
HKD2_k127_4813418_2	1449346.JQMO01000003_gene6440	9.38e-104	355.0	COG1228@1|root,COG1228@2|Bacteria,2GKRZ@201174|Actinobacteria,2M1IA@2063|Kitasatospora	201174|Actinobacteria	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
HKD2_k127_4813418_0	1394178.AWOO02000044_gene4493	2.187e-112	375.0	COG0258@1|root,COG0258@2|Bacteria,2GKTZ@201174|Actinobacteria,4EIBW@85012|Streptosporangiales	201174|Actinobacteria	L	Helix-hairpin-helix class 2 (Pol1 family) motifs	polA_1	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	5_3_exonuc,5_3_exonuc_N
HKD2_k127_4813418_4	1449353.JQMQ01000005_gene801	7.4e-07	61.0	COG1960@1|root,COG1960@2|Bacteria,2GIX8@201174|Actinobacteria,2NHRD@228398|Streptacidiphilus	201174|Actinobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	acdA	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HKD2_k127_482425_19	1246995.AFR_24865	1.063e-15	85.0	COG3979@1|root,COG3979@2|Bacteria,2H72H@201174|Actinobacteria,4DJJD@85008|Micromonosporales	201174|Actinobacteria	S	chitinase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_482425_5	471852.Tcur_1813	6.168e-62	225.0	COG1028@1|root,COG1028@2|Bacteria,2GIYQ@201174|Actinobacteria,4EIJ9@85012|Streptosporangiales	201174|Actinobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.3.1.33	ko:K00218	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R03845,R06286	RC01008	ko00000,ko00001,ko01000	-	-	-	adh_short
HKD2_k127_482425_12	680198.SCAB_62271	6.38e-28	118.0	COG1028@1|root,COG1028@2|Bacteria,2GIYQ@201174|Actinobacteria	201174|Actinobacteria	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	1.3.1.33	ko:K00218	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R03845,R06286	RC01008	ko00000,ko00001,ko01000	-	-	-	adh_short
HKD2_k127_482425_21	1120949.KB903339_gene7900	0.0007037	53.0	COG3979@1|root,COG3979@2|Bacteria,2H72H@201174|Actinobacteria,4DJJD@85008|Micromonosporales	201174|Actinobacteria	S	chitinase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_482425_6	1184609.KILIM_017_00480	1.967e-56	205.0	COG5479@1|root,COG5479@2|Bacteria	2|Bacteria	M	isomerase activity	-	-	-	-	-	-	-	-	-	-	-	-	AbfB,Amidase_2,Glyco_hydro_25,LGFP,Peptidase_M15_4
HKD2_k127_482425_9	1449353.JQMQ01000005_gene3595	8.851e-44	162.0	COG1131@1|root,COG1131@2|Bacteria,2I2I7@201174|Actinobacteria,2NGR9@228398|Streptacidiphilus	201174|Actinobacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD2_k127_482425_2	452652.KSE_30020	3.45e-67	243.0	COG0842@1|root,COG0842@2|Bacteria,2GJ7Y@201174|Actinobacteria,2M1CI@2063|Kitasatospora	201174|Actinobacteria	V	ABC-2 family transporter protein	-	-	-	ko:K01990,ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
HKD2_k127_482425_18	411684.HPDFL43_07374	5.664e-17	88.0	COG2070@1|root,COG2070@2|Bacteria,1MWPC@1224|Proteobacteria,2TQRT@28211|Alphaproteobacteria,43QZH@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	FMN-dependent dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	NMO
HKD2_k127_482425_17	1312959.KI914662_gene3894	2.07e-18	90.0	COG2026@1|root,COG2026@2|Bacteria,2GRQR@201174|Actinobacteria	201174|Actinobacteria	DJ	PFAM plasmid stabilization system	-	-	-	-	-	-	-	-	-	-	-	-	ParE_toxin
HKD2_k127_482425_14	446462.Amir_0172	2.5e-21	100.0	COG0582@1|root,COG0582@2|Bacteria,2GMMI@201174|Actinobacteria,4E5H8@85010|Pseudonocardiales	201174|Actinobacteria	L	Phage integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_3,Phage_integrase
HKD2_k127_482425_15	67267.JNXT01000011_gene1060	3.355e-20	102.0	2EHRE@1|root,33SFK@2|Bacteria,2IK97@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_482425_3	222534.KB893750_gene4329	1.864e-64	223.0	COG0590@1|root,COG0590@2|Bacteria,2IM3Z@201174|Actinobacteria,4ESSJ@85013|Frankiales	201174|Actinobacteria	FJ	Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)	tadA	-	3.5.4.1,3.5.4.33	ko:K01485,ko:K11991	ko00240,ko00330,ko01100,map00240,map00330,map01100	-	R00974,R01411,R02922,R10223	RC00074,RC00477,RC00514,RC00809	ko00000,ko00001,ko01000,ko03016	-	-	-	MafB19-deam,dCMP_cyt_deam_1
HKD2_k127_482425_11	298655.KI912266_gene888	2.388e-41	176.0	2E70D@1|root,331J9@2|Bacteria,2GYEC@201174|Actinobacteria,4ET8B@85013|Frankiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_482425_7	665577.JH993790_gene5317	9.811e-50	199.0	2C7GR@1|root,32H51@2|Bacteria,2IPDA@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_482425_4	1045009.AFXQ01000031_gene43	3.137e-64	248.0	COG0492@1|root,COG0492@2|Bacteria,2GIXN@201174|Actinobacteria,1W97Q@1268|Micrococcaceae	201174|Actinobacteria	O	pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2
HKD2_k127_482425_0	1380356.JNIK01000019_gene425	3.045e-190	609.0	COG0514@1|root,COG0514@2|Bacteria,2GJSS@201174|Actinobacteria,4ERZE@85013|Frankiales	201174|Actinobacteria	L	ATP-dependent DNA helicase RecQ	-	-	3.6.4.12	ko:K03654	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,DUF3553,Helicase_C,RecQ_Zn_bind
HKD2_k127_482425_1	219305.MCAG_01435	9.869e-130	424.0	COG0517@1|root,COG1994@1|root,COG0517@2|Bacteria,COG1994@2|Bacteria,2GJBZ@201174|Actinobacteria,4DCDB@85008|Micromonosporales	201174|Actinobacteria	S	Belongs to the peptidase M50B family	-	-	-	-	-	-	-	-	-	-	-	-	CBS,Peptidase_M50
HKD2_k127_483071_0	1380347.JNII01000005_gene3057	3.343e-170	556.0	COG0671@1|root,COG1718@1|root,COG0671@2|Bacteria,COG1718@2|Bacteria	2|Bacteria	DT	cellular response to dsDNA	kdkA	-	2.7.1.166,3.6.1.27	ko:K11211,ko:K19302	ko00540,ko00550,map00540,map00550	-	R05627,R09767	RC00002,RC00078	ko00000,ko00001,ko01000,ko01011	-	-	-	Kdo,PAP2
HKD2_k127_483071_1	58123.JOFJ01000005_gene1300	2.767e-32	145.0	COG0392@1|root,COG0671@1|root,COG3642@1|root,COG0392@2|Bacteria,COG0671@2|Bacteria,COG3642@2|Bacteria,2GMAV@201174|Actinobacteria,4EHD3@85012|Streptosporangiales	201174|Actinobacteria	I	Lysylphosphatidylglycerol synthase TM region	-	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	LPG_synthase_TM,PAP2
HKD2_k127_486558_2	710111.FraQA3DRAFT_6323	3.189e-98	329.0	COG0566@1|root,COG0566@2|Bacteria,2GJI6@201174|Actinobacteria,4ESPX@85013|Frankiales	201174|Actinobacteria	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family	tsnR	-	-	ko:K03437	-	-	-	-	ko00000,ko03016	-	-	-	SpoU_methylase,SpoU_sub_bind
HKD2_k127_486558_1	298653.Franean1_1732	6.561e-151	492.0	COG0642@1|root,COG2205@2|Bacteria,2GMB9@201174|Actinobacteria,4ES5F@85013|Frankiales	201174|Actinobacteria	T	PAS PAC sensor signal transduction histidine kinase	-	-	2.7.13.3	ko:K18350	ko01502,ko02020,map01502,map02020	M00652,M00657	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko01504,ko02022	-	-	-	HATPase_c,HisKA,PAS,PAS_4
HKD2_k127_486558_0	298653.Franean1_1733	1.825e-154	499.0	COG0016@1|root,COG0016@2|Bacteria,2GJGG@201174|Actinobacteria,4ERUE@85013|Frankiales	201174|Actinobacteria	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily	pheS	GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Phe_tRNA-synt_N,tRNA-synt_2d
HKD2_k127_486558_3	656024.FsymDg_3285	2.232e-74	263.0	COG0072@1|root,COG0073@1|root,COG0072@2|Bacteria,COG0073@2|Bacteria,2GMFD@201174|Actinobacteria,4ES8F@85013|Frankiales	201174|Actinobacteria	J	phenylalanyl-tRNA synthetase beta subunit	pheT	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0019538,GO:0019752,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,tRNA_bind
HKD2_k127_4878819_3	710111.FraQA3DRAFT_5477	2.574e-43	174.0	COG2367@1|root,COG2367@2|Bacteria,2GKPU@201174|Actinobacteria	201174|Actinobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase2
HKD2_k127_4878819_1	656024.FsymDg_3792	2.216e-108	359.0	COG0110@1|root,COG0110@2|Bacteria,2GNUB@201174|Actinobacteria	201174|Actinobacteria	M	Acetyltransferase (isoleucine patch	-	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	2.3.1.79	ko:K00661	-	-	-	-	ko00000,ko01000	-	-	-	Hexapep,Hexapep_2
HKD2_k127_4878819_0	656024.FsymDg_3793	2.054e-139	463.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
HKD2_k127_4878819_2	1123023.JIAI01000006_gene140	4.336e-107	353.0	COG1024@1|root,COG1024@2|Bacteria,2GJW5@201174|Actinobacteria,4DXUE@85010|Pseudonocardiales	201174|Actinobacteria	I	enoyl-CoA hydratase	echA17	GO:0003674,GO:0003824,GO:0004300,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016020,GO:0016042,GO:0016054,GO:0016829,GO:0016835,GO:0016836,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044464,GO:0046395,GO:0055114,GO:0071704,GO:0071944,GO:0072329,GO:1901575	4.2.1.17	ko:K01692	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
HKD2_k127_4894138_1	298653.Franean1_4978	1.041e-90	319.0	COG0477@1|root,COG2814@2|Bacteria,2GKMQ@201174|Actinobacteria,4ESPR@85013|Frankiales	201174|Actinobacteria	EGP	Major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD2_k127_4894138_0	656024.FsymDg_1139	2.915e-138	450.0	COG2133@1|root,COG2133@2|Bacteria,2GISM@201174|Actinobacteria,4ES6J@85013|Frankiales	201174|Actinobacteria	G	Glucose Sorbosone dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	CBM_2,GSDH
HKD2_k127_4894138_4	1122138.AQUZ01000056_gene6954	1.085e-06	59.0	COG0645@1|root,COG0645@2|Bacteria,2GP28@201174|Actinobacteria,4DSP1@85009|Propionibacteriales	201174|Actinobacteria	S	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_33
HKD2_k127_4894138_2	1463936.JOJI01000018_gene7667	3.373e-29	128.0	COG0645@1|root,COG0645@2|Bacteria,2GP28@201174|Actinobacteria	201174|Actinobacteria	S	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_33
HKD2_k127_4894138_3	656024.FsymDg_1164	5.63e-26	112.0	COG1430@1|root,COG1430@2|Bacteria,2GX4D@201174|Actinobacteria	201174|Actinobacteria	S	Uncharacterized ACR, COG1430	-	-	-	ko:K09005	-	-	-	-	ko00000	-	-	-	DUF192
HKD2_k127_4915569_2	656024.FsymDg_2275	1.252e-18	100.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,2GM5Q@201174|Actinobacteria,4ERV9@85013|Frankiales	201174|Actinobacteria	E	Vitamin B12 dependent methionine synthase activation	metH	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008652,GO:0008705,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016741,GO:0019752,GO:0030312,GO:0032259,GO:0042084,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
HKD2_k127_4915569_0	298654.FraEuI1c_3761	2.468e-148	474.0	COG2047@1|root,COG2047@2|Bacteria,2I2H9@201174|Actinobacteria,4EXBU@85013|Frankiales	201174|Actinobacteria	S	PAC2 family	-	-	-	-	-	-	-	-	-	-	-	-	PAC2
HKD2_k127_4915569_3	106370.Francci3_2641	5.446e-18	96.0	COG3599@1|root,COG3599@2|Bacteria	2|Bacteria	D	regulation of cell shape	-	-	-	ko:K07484,ko:K17763,ko:K21471	-	-	-	-	ko00000,ko01000,ko01002,ko01011,ko03021	-	-	-	AsmA,AsmA_2,DivIVA,NLPC_P60
HKD2_k127_4915569_4	365528.KB891102_gene4259	6.646e-09	60.0	COG3599@1|root,COG3599@2|Bacteria	2|Bacteria	D	regulation of cell shape	-	-	-	ko:K07484,ko:K17763,ko:K21471	-	-	-	-	ko00000,ko01000,ko01002,ko01011,ko03021	-	-	-	AsmA,AsmA_2,DivIVA,NLPC_P60
HKD2_k127_4915569_1	1236902.ANAS01000001_gene1804	2.139e-34	134.0	COG0215@1|root,COG0215@2|Bacteria,2GJZR@201174|Actinobacteria,4EH1Y@85012|Streptosporangiales	201174|Actinobacteria	J	Catalyzes the ATP-dependent condensation of GlcN-Ins and L-cysteine to form L-Cys-GlcN-Ins	mshC	GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010125,GO:0010126,GO:0010467,GO:0016020,GO:0016070,GO:0016137,GO:0016138,GO:0016874,GO:0016875,GO:0016879,GO:0016880,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035446,GO:0035639,GO:0036094,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044272,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	6.1.1.16,6.3.1.13	ko:K01883,ko:K15526	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iNJ661.Rv2130c	tRNA-synt_1e
HKD2_k127_499498_0	443218.AS9A_2383	2.252e-246	772.0	COG2303@1|root,COG2303@2|Bacteria,2GJ3J@201174|Actinobacteria,23837@1762|Mycobacteriaceae	201174|Actinobacteria	E	GMC oxidoreductase	-	-	1.1.3.6	ko:K03333	ko00984,ko01120,map00984,map01120	-	R01459	RC00146	ko00000,ko00001,ko01000	-	-	-	DAO,FAD_binding_2,GMC_oxred_C,GMC_oxred_N
HKD2_k127_499498_3	656024.FsymDg_4278	1.006e-65	228.0	COG0245@1|root,COG0245@2|Bacteria,2II8H@201174|Actinobacteria,4ESX7@85013|Frankiales	201174|Actinobacteria	I	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP)	ispF	GO:0003674,GO:0003824,GO:0006629,GO:0006720,GO:0006721,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008685,GO:0009058,GO:0009987,GO:0016114,GO:0016829,GO:0016849,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0051483,GO:0071704,GO:1901576	2.7.7.60,4.6.1.12	ko:K01770,ko:K12506	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633,R05637	RC00002,RC01440	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv3581c	YgbB
HKD2_k127_499498_2	656024.FsymDg_4279	1.141e-69	248.0	COG1211@1|root,COG1211@2|Bacteria,2GNHP@201174|Actinobacteria,4ETF1@85013|Frankiales	201174|Actinobacteria	I	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP)	ispD	GO:0000166,GO:0000287,GO:0001882,GO:0001884,GO:0002135,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008270,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016020,GO:0016114,GO:0016740,GO:0016772,GO:0016779,GO:0019103,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030145,GO:0032549,GO:0032551,GO:0032553,GO:0032557,GO:0032787,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044464,GO:0046490,GO:0046872,GO:0046914,GO:0050518,GO:0051483,GO:0051484,GO:0070567,GO:0071704,GO:0071944,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901265,GO:1901363,GO:1901576	2.7.7.60	ko:K00991	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	IspD
HKD2_k127_499498_1	710111.FraQA3DRAFT_5197	6.3e-93	306.0	COG1329@1|root,COG1329@2|Bacteria,2GKSU@201174|Actinobacteria,4ES60@85013|Frankiales	201174|Actinobacteria	K	Transcriptional regulator, CarD family	carD	GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009405,GO:0009605,GO:0009987,GO:0009991,GO:0015968,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0040007,GO:0042594,GO:0044419,GO:0050896,GO:0051704,GO:0051716,GO:0071496	-	ko:K07736	-	-	-	-	ko00000,ko03000	-	-	-	CarD_CdnL_TRCF
HKD2_k127_499498_4	656024.FsymDg_4282	5.594e-45	174.0	2EKJI@1|root,33E9C@2|Bacteria,2H0DV@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_499498_5	1214101.BN159_5917	4.371e-17	81.0	COG3424@1|root,COG3424@2|Bacteria,2GV0U@201174|Actinobacteria	201174|Actinobacteria	Q	synthase	-	-	-	ko:K16167	-	-	-	-	ko00000,ko01008	-	-	-	Chal_sti_synt_C,Chal_sti_synt_N
HKD2_k127_5007214_3	471852.Tcur_1221	9.758e-09	59.0	COG1044@1|root,COG3064@1|root,COG1044@2|Bacteria,COG3064@2|Bacteria,2IH85@201174|Actinobacteria	201174|Actinobacteria	M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S55
HKD2_k127_5007214_2	471852.Tcur_1221	1.945e-65	245.0	COG1044@1|root,COG3064@1|root,COG1044@2|Bacteria,COG3064@2|Bacteria,2IH85@201174|Actinobacteria	201174|Actinobacteria	M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S55
HKD2_k127_5007214_0	208439.AJAP_15665	3.358e-282	910.0	COG0366@1|root,COG3387@1|root,COG0366@2|Bacteria,COG3387@2|Bacteria,2HCB8@201174|Actinobacteria,4E21Z@85010|Pseudonocardiales	201174|Actinobacteria	G	Glucodextranase, domain N	-	-	3.2.1.3	ko:K01178	ko00500,ko01100,map00500,map01100	-	R01790,R01791,R06199	-	ko00000,ko00001,ko01000	-	GH15	-	CBM_20,Glucodextran_N,Glyco_hydro_15,fn3
HKD2_k127_5007214_1	1380347.JNII01000011_gene1067	2.226e-82	291.0	COG0726@1|root,COG3858@1|root,COG0726@2|Bacteria,COG3858@2|Bacteria,2HES0@201174|Actinobacteria,4EW3X@85013|Frankiales	201174|Actinobacteria	G	polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5060_8	1209984.BN978_06420	9.948e-11	65.0	COG2217@1|root,COG2217@2|Bacteria,2GIRF@201174|Actinobacteria,235KJ@1762|Mycobacteriaceae	201174|Actinobacteria	P	heavy metal translocating P-type ATPase	-	-	3.6.3.4,3.6.3.54	ko:K01533,ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,Hemerythrin,Hydrolase
HKD2_k127_5060_5	710111.FraQA3DRAFT_0697	3.52e-57	217.0	COG0589@1|root,COG0589@2|Bacteria,2GMFE@201174|Actinobacteria,4EW1U@85013|Frankiales	201174|Actinobacteria	T	Belongs to the universal stress protein A family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD2_k127_5060_6	345341.KUTG_00520	7.444e-19	93.0	COG0589@1|root,COG0589@2|Bacteria,2IQPQ@201174|Actinobacteria,4E6RZ@85010|Pseudonocardiales	201174|Actinobacteria	T	Universal stress protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD2_k127_5060_1	1172188.KB911820_gene2749	1.438e-170	549.0	COG1063@1|root,COG1063@2|Bacteria,2GISW@201174|Actinobacteria,4FEE3@85021|Intrasporangiaceae	201174|Actinobacteria	E	Alcohol dehydrogenase GroES-like domain	-	-	-	ko:K18369	ko00640,map00640	-	R10703	RC00545	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_N_assoc,ADH_zinc_N
HKD2_k127_5060_7	106370.Francci3_1559	4.601e-15	81.0	2EH65@1|root,3351X@2|Bacteria,2HUNA@201174|Actinobacteria,4EWVN@85013|Frankiales	201174|Actinobacteria	S	Domain of unknown function (DUF1876)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1876
HKD2_k127_5060_0	298655.KI912266_gene2842	6.117e-292	923.0	COG1042@1|root,COG1042@2|Bacteria,2GKN1@201174|Actinobacteria,4ERT2@85013|Frankiales	201174|Actinobacteria	C	CoA-binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig
HKD2_k127_5060_2	1386089.N865_16800	9.128e-150	521.0	COG0438@1|root,COG0438@2|Bacteria,2ICGI@201174|Actinobacteria	201174|Actinobacteria	M	Glycosyl transferases group 1	-	-	2.4.1.245	ko:K13057	ko00500,ko01100,map00500,map01100	-	R08946,R10525,R11306	RC00005,RC00049,RC02748	ko00000,ko00001,ko01000	-	GT4	-	Glycos_transf_1,YHS
HKD2_k127_5060_4	298653.Franean1_6938	2.12e-68	241.0	COG2905@1|root,COG2905@2|Bacteria,2GVP5@201174|Actinobacteria,4EWMQ@85013|Frankiales	201174|Actinobacteria	T	CBS domains	-	-	-	-	-	-	-	-	-	-	-	-	CBS,DUF1918
HKD2_k127_5060_3	146922.JOFU01000083_gene4016	1.067e-74	260.0	COG1584@1|root,COG1584@2|Bacteria,2IIIX@201174|Actinobacteria	201174|Actinobacteria	S	PFAM GPR1 FUN34 yaaH family	-	-	-	ko:K07034	-	-	-	-	ko00000	-	-	-	Grp1_Fun34_YaaH
HKD2_k127_5111323_7	105422.BBPM01000015_gene1930	3.242e-06	53.0	2EEXH@1|root,338QV@2|Bacteria,2ICQN@201174|Actinobacteria,2NKJZ@228398|Streptacidiphilus	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	GT87,PMT_2
HKD2_k127_5111323_0	1121272.KB903250_gene2798	1.7e-219	698.0	COG1216@1|root,COG2227@1|root,COG1216@2|Bacteria,COG2227@2|Bacteria	2|Bacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2,Methyltransf_23
HKD2_k127_5111323_5	1121272.KB903250_gene2797	3.529e-43	165.0	COG2076@1|root,COG2076@2|Bacteria,2IKGD@201174|Actinobacteria	201174|Actinobacteria	P	Small Multidrug Resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	EamA,Multi_Drug_Res
HKD2_k127_5111323_4	743718.Isova_2392	3.858e-48	181.0	COG2227@1|root,COG2227@2|Bacteria,2I54M@201174|Actinobacteria,4F551@85017|Promicromonosporaceae	201174|Actinobacteria	H	PFAM Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23
HKD2_k127_5111323_2	436229.JOEH01000009_gene4709	1.715e-103	359.0	COG0438@1|root,COG0438@2|Bacteria,2IA6D@201174|Actinobacteria,2NKZP@228398|Streptacidiphilus	201174|Actinobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4
HKD2_k127_5111323_1	656024.FsymDg_1056	3.548e-157	525.0	COG1807@1|root,COG1807@2|Bacteria,2IME4@201174|Actinobacteria,4EVSG@85013|Frankiales	201174|Actinobacteria	M	Predicted membrane protein (DUF2142)	-	-	-	ko:K17414	-	-	-	-	br01610,ko00000,ko03011	-	-	-	DUF2142,PMT_2
HKD2_k127_5111323_3	656024.FsymDg_1057	2.287e-96	322.0	COG0110@1|root,COG0110@2|Bacteria,2GWDX@201174|Actinobacteria	201174|Actinobacteria	S	Bacterial transferase hexapeptide (six repeats)	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep,Hexapep_2
HKD2_k127_5111323_6	1137269.AZWL01000003_gene1417	3.223e-06	60.0	COG5305@1|root,COG5305@2|Bacteria,2GN7C@201174|Actinobacteria	201174|Actinobacteria	S	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	ko:K14340	-	-	-	-	ko00000,ko01000,ko01003	-	-	-	PMT_2
HKD2_k127_511848_3	263358.VAB18032_13950	2.092e-43	160.0	COG0033@1|root,COG0033@2|Bacteria,2H1PI@201174|Actinobacteria,4D938@85008|Micromonosporales	201174|Actinobacteria	G	Phosphoglucomutase	pgm	-	5.4.2.2	ko:K01835	ko00010,ko00030,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00549	R00959,R01057,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
HKD2_k127_511848_1	298655.KI912266_gene5481	3.387e-111	374.0	COG3552@1|root,COG3552@2|Bacteria,2GNTS@201174|Actinobacteria,4EUJS@85013|Frankiales	201174|Actinobacteria	S	Protein containing von Willebrand factor type A (VWA) domain	-	-	-	ko:K07161	-	-	-	-	ko00000	-	-	-	VWA_CoxE
HKD2_k127_511848_2	365528.KB891102_gene4570	1.685e-92	329.0	COG3552@1|root,COG3552@2|Bacteria,2GNTS@201174|Actinobacteria,4EUJS@85013|Frankiales	201174|Actinobacteria	S	Protein containing von Willebrand factor type A (VWA) domain	-	-	-	ko:K07161	-	-	-	-	ko00000	-	-	-	VWA_CoxE
HKD2_k127_511848_0	656024.FsymDg_1549	4.415e-144	464.0	COG0714@1|root,COG0714@2|Bacteria,2GMM2@201174|Actinobacteria,4ETQ9@85013|Frankiales	201174|Actinobacteria	S	PFAM ATPase associated with various cellular activities	-	-	-	-	-	-	-	-	-	-	-	-	AAA,AAA_5
HKD2_k127_511848_4	1122609.AUGT01000011_gene3491	1.009e-38	146.0	COG1620@1|root,COG1620@2|Bacteria,2GIUF@201174|Actinobacteria,4DPUA@85009|Propionibacteriales	201174|Actinobacteria	C	L-lactate permease	lutP	-	-	ko:K03303	-	-	-	-	ko00000,ko02000	2.A.14	-	-	Lactate_perm
HKD2_k127_5121039_1	106370.Francci3_4318	1.477e-71	249.0	COG0561@1|root,COG0561@2|Bacteria,2GP42@201174|Actinobacteria,4ESRA@85013|Frankiales	201174|Actinobacteria	S	HAD-superfamily hydrolase, subfamily IIB	cof	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_3
HKD2_k127_5121039_2	345341.KUTG_07962	4.681e-15	85.0	COG1724@1|root,COG1724@2|Bacteria	2|Bacteria	N	mRNA binding	-	-	-	ko:K07339	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	HicA_toxin
HKD2_k127_5121039_3	1158182.KB905020_gene2291	1.424e-13	76.0	COG1598@1|root,COG1598@2|Bacteria,1NBIX@1224|Proteobacteria,1SCV3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	HicB_like antitoxin of bacterial toxin-antitoxin system	-	-	-	-	-	-	-	-	-	-	-	-	HicB_lk_antitox
HKD2_k127_5121039_0	656024.FsymDg_0236	7.981e-76	263.0	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	yobR	GO:0003674,GO:0003824,GO:0004596,GO:0005575,GO:0005622,GO:0005623,GO:0006464,GO:0006473,GO:0006474,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019538,GO:0031248,GO:0031365,GO:0032991,GO:0034212,GO:0036211,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051604,GO:0071704,GO:1901564,GO:1902493,GO:1902494,GO:1990234	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10
HKD2_k127_5140726_2	710111.FraQA3DRAFT_3890	3.85e-67	231.0	COG0436@1|root,COG0436@2|Bacteria,2GJ7R@201174|Actinobacteria,4ES0T@85013|Frankiales	201174|Actinobacteria	E	aminotransferase class I and II	aspC	-	2.6.1.1	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
HKD2_k127_5140726_4	1184609.KILIM_072_00190	3.631e-31	134.0	COG1051@1|root,COG1051@2|Bacteria,2HYHQ@201174|Actinobacteria,4F71J@85018|Dermatophilaceae	201174|Actinobacteria	F	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
HKD2_k127_5140726_7	1184609.KILIM_021_00400	1.579e-16	82.0	COG2402@1|root,COG2402@2|Bacteria,2IRQ5@201174|Actinobacteria	201174|Actinobacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	ko:K07065	-	-	-	-	ko00000	-	-	-	PIN
HKD2_k127_5140726_0	298654.FraEuI1c_0438	1.919e-182	599.0	COG0477@1|root,COG0477@2|Bacteria,2GIUM@201174|Actinobacteria	201174|Actinobacteria	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
HKD2_k127_5140726_3	298654.FraEuI1c_1546	3.598e-61	216.0	COG1309@1|root,COG1309@2|Bacteria,2GYI1@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
HKD2_k127_5140726_6	1121019.AUMN01000009_gene1867	1.634e-22	103.0	COG3620@1|root,COG3620@2|Bacteria,2GWYK@201174|Actinobacteria	201174|Actinobacteria	K	Helix-turn-helix	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
HKD2_k127_5140726_1	710111.FraQA3DRAFT_5647	1.861e-100	342.0	COG1396@1|root,COG1396@2|Bacteria,2I3J1@201174|Actinobacteria	201174|Actinobacteria	K	sequence-specific DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5140741_5	326424.FRAAL1141	5.36e-06	57.0	COG0515@1|root,COG0515@2|Bacteria	326424.FRAAL1141|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5140741_4	298655.KI912266_gene269	9.733e-09	64.0	COG2229@1|root,COG2229@2|Bacteria,2GJIT@201174|Actinobacteria	201174|Actinobacteria	S	ATP- GTP-binding protein	-	-	-	ko:K06945	-	-	-	-	ko00000	-	-	-	ATP_bind_1
HKD2_k127_5140741_0	656024.FsymDg_3904	4.488e-82	282.0	COG2229@1|root,COG2229@2|Bacteria,2GJIT@201174|Actinobacteria	201174|Actinobacteria	S	ATP- GTP-binding protein	-	-	-	ko:K06945	-	-	-	-	ko00000	-	-	-	ATP_bind_1
HKD2_k127_5140741_3	1463864.JOGO01000140_gene247	8.616e-21	96.0	COG1846@1|root,COG1846@2|Bacteria,2II46@201174|Actinobacteria	201174|Actinobacteria	K	Protein of unknown function (DUF742)	-	-	-	-	-	-	-	-	-	-	-	-	DUF742
HKD2_k127_5140741_1	106370.Francci3_0643	6.121e-73	247.0	COG2018@1|root,COG2018@2|Bacteria,2IFB7@201174|Actinobacteria	201174|Actinobacteria	S	Roadblock lc7 family protein	cvnB6	-	-	ko:K07131	-	-	-	-	ko00000	-	-	-	Robl_LC7
HKD2_k127_5150952_10	298653.Franean1_6144	4.182e-80	270.0	COG0248@1|root,COG0248@2|Bacteria,2GMME@201174|Actinobacteria,4ETV1@85013|Frankiales	201174|Actinobacteria	FP	PFAM Ppx GppA phosphatase	ppx1	GO:0003674,GO:0003824,GO:0006793,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0044237	3.6.1.11,3.6.1.40	ko:K01524	ko00230,map00230	-	R03409	RC00002	ko00000,ko00001,ko01000	-	-	-	Ppx-GppA
HKD2_k127_5150952_3	656024.FsymDg_4064	1.118e-145	466.0	COG1082@1|root,COG1082@2|Bacteria,2GJ6E@201174|Actinobacteria,4ERMT@85013|Frankiales	201174|Actinobacteria	G	PFAM Xylose isomerase	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
HKD2_k127_5150952_9	298654.FraEuI1c_6320	6.143e-98	340.0	COG0500@1|root,COG2226@2|Bacteria,2HWAV@201174|Actinobacteria	201174|Actinobacteria	Q	Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
HKD2_k127_5150952_6	345341.KUTG_00500	8.402e-119	392.0	COG0842@1|root,COG0842@2|Bacteria,2GJ7Y@201174|Actinobacteria,4E0WZ@85010|Pseudonocardiales	201174|Actinobacteria	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane,ABC2_membrane_3
HKD2_k127_5150952_4	1121952.ATXT01000013_gene2421	1.466e-124	444.0	COG1131@1|root,COG1131@2|Bacteria,2ICIF@201174|Actinobacteria	201174|Actinobacteria	V	ABC transporter	-	-	-	ko:K01990,ko:K13926	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD2_k127_5150952_5	263358.VAB18032_01850	6.497e-120	392.0	COG0506@1|root,COG0506@2|Bacteria,2GJTK@201174|Actinobacteria,4DB1R@85008|Micromonosporales	201174|Actinobacteria	E	Proline dehydrogenase	-	-	-	ko:K00318	ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130	-	R10507	RC00083	ko00000,ko00001,ko01000	-	-	-	Pro_dh
HKD2_k127_5150952_7	105422.BBPM01000008_gene6360	6.54e-117	393.0	COG0345@1|root,COG0345@2|Bacteria,2GJ7D@201174|Actinobacteria,2NGJS@228398|Streptacidiphilus	201174|Actinobacteria	E	Pyrroline-5-carboxylate reductase dimerisation	proC	GO:0000287,GO:0003674,GO:0003824,GO:0004735,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0018130,GO:0019752,GO:0030145,GO:0040007,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0046914,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.5.1.2	ko:K00286	ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230	M00015	R01248,R01251,R03291,R03293	RC00054,RC00083	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_oxidored,P5CR_dimer
HKD2_k127_5150952_0	106370.Francci3_3503	1.393e-156	503.0	COG0123@1|root,COG0123@2|Bacteria,2GJUH@201174|Actinobacteria,4ES09@85013|Frankiales	201174|Actinobacteria	BQ	PFAM Histone deacetylase	acuC	-	-	ko:K04768	-	-	-	-	ko00000	-	-	-	Hist_deacetyl
HKD2_k127_5150952_8	710111.FraQA3DRAFT_3977	5.311e-113	372.0	COG1912@1|root,COG1912@2|Bacteria,2IASJ@201174|Actinobacteria	201174|Actinobacteria	S	transferase activity, transferring alkyl or aryl (other than methyl) groups	-	-	-	ko:K22205	-	-	-	-	ko00000,ko01000	-	-	-	SAM_adeno_trans
HKD2_k127_5150952_1	656024.FsymDg_4059	1.064e-152	490.0	COG0451@1|root,COG0451@2|Bacteria,2GNT1@201174|Actinobacteria,4ERGC@85013|Frankiales	201174|Actinobacteria	M	PFAM NAD-dependent epimerase dehydratase	galE2	GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv0501	Epimerase
HKD2_k127_5150952_2	298655.KI912266_gene437	5.666e-147	481.0	COG0204@1|root,COG0204@2|Bacteria,2GJKH@201174|Actinobacteria,4ESBP@85013|Frankiales	201174|Actinobacteria	I	PFAM Phospholipid glycerol acyltransferase	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Acyltransferase
HKD2_k127_5151894_2	83332.Rv1041c	7.789e-63	224.0	COG3293@1|root,COG3293@2|Bacteria,2GN92@201174|Actinobacteria,239P5@1762|Mycobacteriaceae	201174|Actinobacteria	L	Transposase DDE domain	-	-	-	ko:K07492	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DDE_Tnp_1_2
HKD2_k127_5151894_1	1123320.KB889719_gene7247	3.455e-190	602.0	COG0626@1|root,COG0626@2|Bacteria,2GJ5S@201174|Actinobacteria	201174|Actinobacteria	E	Catalyzes the formation of L-homocysteine from O- succinyl-L-homoserine (OSHS) and hydrogen sulfide	metB	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0003962,GO:0004123,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006534,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009070,GO:0009086,GO:0009092,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016765,GO:0016829,GO:0016846,GO:0017144,GO:0019279,GO:0019343,GO:0019344,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071265,GO:0071266,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.5.1.48	ko:K01739	ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017	R00999,R01288,R02508,R03217,R03260,R04944,R04945,R04946	RC00020,RC00056,RC00069,RC00420,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv1079	Cys_Met_Meta_PP
HKD2_k127_5151894_0	298653.Franean1_0818	9.239e-210	691.0	COG1696@1|root,COG1696@2|Bacteria,2GM6Z@201174|Actinobacteria,4EUU2@85013|Frankiales	201174|Actinobacteria	M	MBOAT, membrane-bound O-acyltransferase family	algI	-	-	ko:K03739,ko:K19294	ko01503,ko02020,ko05150,map01503,map02020,map05150	M00725	-	-	ko00000,ko00001,ko00002,ko01504	-	-	-	MBOAT
HKD2_k127_5153512_2	526225.Gobs_0950	1.489e-95	316.0	COG0020@1|root,COG0020@2|Bacteria,2GJCP@201174|Actinobacteria,4ERVD@85013|Frankiales	201174|Actinobacteria	I	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids	uppS1	GO:0000287,GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016020,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0030145,GO:0033850,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0046872,GO:0046914,GO:0071704,GO:0071944,GO:1901576,GO:1901615,GO:1901617	2.5.1.31,2.5.1.68	ko:K00806,ko:K12503	ko00900,ko01110,map00900,map01110	-	R06447,R08528	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
HKD2_k127_5153512_0	656024.FsymDg_0786	1.405e-236	739.0	COG1875@1|root,COG1875@2|Bacteria,2GK8U@201174|Actinobacteria,4ERNC@85013|Frankiales	201174|Actinobacteria	T	SMART Nucleotide binding protein, PINc	phoH2	-	-	ko:K07175	-	-	-	-	ko00000	-	-	-	PIN_4,PhoH
HKD2_k127_5153512_1	656024.FsymDg_0787	3.977e-107	355.0	COG0225@1|root,COG0225@2|Bacteria,2GJ1S@201174|Actinobacteria,4ESDQ@85013|Frankiales	201174|Actinobacteria	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	msrA	-	1.8.4.11	ko:K07304	-	-	-	-	ko00000,ko01000	-	-	-	PMSR
HKD2_k127_5153512_3	1449976.KALB_75	9.094e-53	190.0	COG4683@1|root,COG4683@2|Bacteria,2IFY3@201174|Actinobacteria,4EB36@85010|Pseudonocardiales	201174|Actinobacteria	S	Phage derived protein Gp49-like (DUF891)	-	-	-	-	-	-	-	-	-	-	-	-	Gp49
HKD2_k127_5153512_5	1449976.KALB_76	2.761e-39	148.0	COG3620@1|root,COG3620@2|Bacteria,2IKRP@201174|Actinobacteria,4ECA5@85010|Pseudonocardiales	201174|Actinobacteria	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3,HTH_31
HKD2_k127_5153512_6	1169161.KB897717_gene2932	1.026e-08	57.0	COG0225@1|root,COG0225@2|Bacteria,2GJ1S@201174|Actinobacteria	201174|Actinobacteria	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	msrA	-	1.8.4.11	ko:K07304	-	-	-	-	ko00000,ko01000	-	-	-	PMSR
HKD2_k127_5153512_4	1089546.AQUI01000002_gene687	4.952e-44	170.0	COG3170@1|root,COG3170@2|Bacteria,2ICMF@201174|Actinobacteria	201174|Actinobacteria	NU	Tfp pilus assembly protein FimV	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5156228_3	685778.AORL01000024_gene190	4.324e-23	106.0	COG0535@1|root,COG0535@2|Bacteria,1PGN3@1224|Proteobacteria,2VE46@28211|Alphaproteobacteria,2KBV1@204457|Sphingomonadales	204457|Sphingomonadales	S	Iron-sulfur cluster-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM,SPASM
HKD2_k127_5156228_2	1120949.KB903295_gene2493	2.644e-28	121.0	COG0707@1|root,COG0707@2|Bacteria	2|Bacteria	M	undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity	cpsF	-	-	-	-	-	-	-	-	-	-	-	Alg14
HKD2_k127_5156228_7	309801.trd_1849	3.38e-08	66.0	COG0500@1|root,COG2226@2|Bacteria,2G9CY@200795|Chloroflexi	200795|Chloroflexi	Q	Methyltransferase type 12	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
HKD2_k127_5156228_8	240015.ACP_1043	2.45e-07	63.0	COG0535@1|root,COG0535@2|Bacteria	2|Bacteria	I	radical SAM domain protein	-	-	-	ko:K07011,ko:K22227	-	-	-	-	ko00000	-	-	-	Fer4_12,Fer4_14,Radical_SAM,SPASM
HKD2_k127_5156228_6	401526.TcarDRAFT_1072	5.415e-11	77.0	COG0535@1|root,COG0535@2|Bacteria,1TR85@1239|Firmicutes,4H1UM@909932|Negativicutes	909932|Negativicutes	C	Radical SAM	nirJ	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM,SPASM
HKD2_k127_5156228_5	2074.JNYD01000009_gene5292	4.253e-14	82.0	COG0500@1|root,COG2226@2|Bacteria,2GNJS@201174|Actinobacteria,4E1EP@85010|Pseudonocardiales	201174|Actinobacteria	Q	Hypothetical methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
HKD2_k127_5156228_4	326424.FRAAL5453	5.537e-17	81.0	COG3311@1|root,COG3311@2|Bacteria,2GZDC@201174|Actinobacteria	201174|Actinobacteria	K	regulatory protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5156228_0	928724.SacglDRAFT_03688	4.388e-81	279.0	COG3293@1|root,COG3293@2|Bacteria,2IIAY@201174|Actinobacteria,4E3DP@85010|Pseudonocardiales	201174|Actinobacteria	L	PFAM Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_2,DUF4096
HKD2_k127_5159478_3	365528.KB891252_gene5552	5.32e-59	211.0	COG1214@1|root,COG1214@2|Bacteria,2GMTM@201174|Actinobacteria,4ET0P@85013|Frankiales	201174|Actinobacteria	O	PFAM Peptidase M22, glycoprotease	yeaZ	GO:0002949,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030312,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0071944,GO:0090304,GO:1901360	-	ko:K14742	-	-	-	-	ko00000,ko03016	-	-	-	Peptidase_M22
HKD2_k127_5159478_6	861299.J421_0733	4.575e-46	188.0	COG0637@1|root,COG0637@2|Bacteria	2|Bacteria	S	phosphonoacetaldehyde hydrolase activity	-	-	3.1.3.23	ko:K19270	-	-	-	-	ko00000,ko01000	-	-	-	HAD_2
HKD2_k127_5159478_4	298655.KI912266_gene284	1.5e-51	205.0	COG0802@1|root,COG0802@2|Bacteria,2IKV2@201174|Actinobacteria,4ESZ5@85013|Frankiales	201174|Actinobacteria	S	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	tsaE	GO:0008150,GO:0040007	-	ko:K06925	-	-	-	-	ko00000,ko03016	-	-	-	TsaE
HKD2_k127_5159478_5	1211815.CBYP010000046_gene867	5.982e-50	201.0	COG1573@1|root,COG1573@2|Bacteria,2GMPT@201174|Actinobacteria,4EVJB@85013|Frankiales	201174|Actinobacteria	L	Uracil-DNA glycosylase	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
HKD2_k127_5159478_2	106370.Francci3_0625	2.112e-115	400.0	COG2267@1|root,COG2267@2|Bacteria,2GMCK@201174|Actinobacteria,4ESNI@85013|Frankiales	201174|Actinobacteria	I	PFAM Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6,Hydrolase_4
HKD2_k127_5159478_0	106370.Francci3_0622	1.275e-175	567.0	COG0787@1|root,COG0787@2|Bacteria,2GM2Y@201174|Actinobacteria,4ERH5@85013|Frankiales	201174|Actinobacteria	E	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids	alr	-	5.1.1.1	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	-	R00401	RC00285	ko00000,ko00001,ko01000,ko01011	-	-	-	Ala_racemase_C,Ala_racemase_N
HKD2_k127_5159478_1	656024.FsymDg_3923	3.34e-170	554.0	COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,2GJHB@201174|Actinobacteria,4ERGP@85013|Frankiales	201174|Actinobacteria	G	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	-	4.2.1.136,5.1.99.6	ko:K17758,ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	Carb_kinase,YjeF_N
HKD2_k127_5159478_7	710111.FraQA3DRAFT_3835	3.503e-42	159.0	COG0736@1|root,COG0736@2|Bacteria,2IQF6@201174|Actinobacteria,4ET64@85013|Frankiales	201174|Actinobacteria	I	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein	acpS	-	2.7.8.7	ko:K00997	ko00770,map00770	-	R01625	RC00002	ko00000,ko00001,ko01000	-	-	-	ACPS
HKD2_k127_5159478_10	1123360.thalar_00584	1.373e-11	76.0	COG1396@1|root,COG1396@2|Bacteria,1NC77@1224|Proteobacteria,2U9U8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_37
HKD2_k127_5159478_8	1229780.BN381_50050	8.65e-28	119.0	COG4683@1|root,COG4683@2|Bacteria,2IQAB@201174|Actinobacteria	201174|Actinobacteria	S	Phage derived protein Gp49-like (DUF891)	-	-	-	-	-	-	-	-	-	-	-	-	Gp49
HKD2_k127_5159478_11	106370.Francci3_4031	1.178e-09	65.0	COG2402@1|root,COG2402@2|Bacteria,2IRQ5@201174|Actinobacteria	201174|Actinobacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	ko:K07065	-	-	-	-	ko00000	-	-	-	PIN
HKD2_k127_5159478_12	1463825.JNXC01000005_gene2485	1.214e-07	55.0	29WM0@1|root,30I7P@2|Bacteria,2HRZT@201174|Actinobacteria,4EBJQ@85010|Pseudonocardiales	201174|Actinobacteria	S	PFAM Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_4,HTH_Tnp_4
HKD2_k127_515969_0	710111.FraQA3DRAFT_5846	0.0	1379.0	COG3957@1|root,COG3957@2|Bacteria,2GN27@201174|Actinobacteria,4ERMR@85013|Frankiales	201174|Actinobacteria	G	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase	xfp	-	4.1.2.22,4.1.2.9	ko:K01621	ko00030,ko00710,ko01100,ko01120,map00030,map00710,map01100,map01120	-	R00761,R01621	RC00032,RC00226	ko00000,ko00001,ko01000	-	-	-	XFP,XFP_C,XFP_N
HKD2_k127_515969_4	656024.FsymDg_2372	7.825e-74	250.0	COG1522@1|root,COG1522@2|Bacteria,2GK3G@201174|Actinobacteria,4ESKM@85013|Frankiales	201174|Actinobacteria	K	Regulator	lrp_3	-	-	ko:K03719	-	-	-	-	ko00000,ko03000,ko03036	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
HKD2_k127_515969_2	1463825.JNXC01000040_gene5121	6.027e-88	309.0	COG0524@1|root,COG0524@2|Bacteria,2GYHF@201174|Actinobacteria,4DYH7@85010|Pseudonocardiales	201174|Actinobacteria	G	PFAM pfkB family carbohydrate kinase	pfkB	-	2.7.1.4	ko:K00847	ko00051,ko00500,ko00520,ko01100,map00051,map00500,map00520,map01100	-	R00760,R00867,R03920	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
HKD2_k127_515969_1	1380390.JIAT01000010_gene4483	7.083e-92	324.0	COG1475@1|root,COG1475@2|Bacteria,2IAI6@201174|Actinobacteria,4CQE8@84995|Rubrobacteria	84995|Rubrobacteria	K	DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	ParBc
HKD2_k127_515969_5	1123023.JIAI01000001_gene6499	1.489e-66	243.0	COG0329@1|root,COG0329@2|Bacteria,2IM0E@201174|Actinobacteria	201174|Actinobacteria	EM	Dihydrodipicolinate synthetase family	-	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
HKD2_k127_515969_7	675635.Psed_1324	1.02e-38	152.0	COG1396@1|root,COG1396@2|Bacteria,2GTN6@201174|Actinobacteria	201174|Actinobacteria	K	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3,HTH_31
HKD2_k127_515969_6	675635.Psed_1323	1.398e-49	186.0	COG4683@1|root,COG4683@2|Bacteria,2IQAB@201174|Actinobacteria,4EBYE@85010|Pseudonocardiales	201174|Actinobacteria	S	Phage derived protein Gp49-like (DUF891)	-	-	-	-	-	-	-	-	-	-	-	-	Gp49
HKD2_k127_515969_3	928724.SacglDRAFT_00723	8.578e-79	268.0	COG2129@1|root,COG2129@2|Bacteria,2ICBG@201174|Actinobacteria,4DYD7@85010|Pseudonocardiales	201174|Actinobacteria	S	Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos,Metallophos_2
HKD2_k127_5164596_4	981369.JQMJ01000004_gene4865	5.155e-11	66.0	COG0677@1|root,COG0677@2|Bacteria,2GK5K@201174|Actinobacteria,2NENN@228398|Streptacidiphilus	201174|Actinobacteria	M	UDP binding domain	-	-	1.1.1.136,1.1.1.336	ko:K02472,ko:K13015	ko00520,ko05111,map00520,map05111	-	R00421,R03317	RC00291	ko00000,ko00001,ko01000,ko01005	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
HKD2_k127_5164596_2	330084.JNYZ01000007_gene8858	5.533e-41	168.0	COG3247@1|root,COG3247@2|Bacteria,2HZE6@201174|Actinobacteria,4E5JN@85010|Pseudonocardiales	201174|Actinobacteria	S	Short repeat of unknown function (DUF308)	-	-	-	-	-	-	-	-	-	-	-	-	DUF308
HKD2_k127_5164596_1	935839.JAGJ01000019_gene2282	4.611e-45	179.0	COG0542@1|root,COG0542@2|Bacteria,2GJ77@201174|Actinobacteria,4F3SD@85017|Promicromonosporaceae	201174|Actinobacteria	O	Bacterial TniB protein	-	-	-	ko:K03696,ko:K03697	ko01100,map01100	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N,UVR
HKD2_k127_5164596_0	471852.Tcur_0827	8.618e-52	187.0	COG0748@1|root,COG0748@2|Bacteria,2IFHD@201174|Actinobacteria,4EK8J@85012|Streptosporangiales	201174|Actinobacteria	P	pyridoxamine 5-phosphate	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
HKD2_k127_5164596_3	266940.Krad_3500	1.071e-16	81.0	COG2116@1|root,COG2116@2|Bacteria,2GNU6@201174|Actinobacteria	201174|Actinobacteria	P	Formate nitrite	focA	-	-	-	-	-	-	-	-	-	-	-	Form_Nir_trans
HKD2_k127_5165549_3	1048339.KB913029_gene2162	2.605e-09	70.0	COG1932@1|root,COG1932@2|Bacteria,2GKYK@201174|Actinobacteria,4ERX6@85013|Frankiales	201174|Actinobacteria	E	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine	serC	GO:0001505,GO:0003674,GO:0003824,GO:0004760,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0005886,GO:0006082,GO:0006520,GO:0006544,GO:0006545,GO:0006807,GO:0008150,GO:0008152,GO:0008453,GO:0008483,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016769,GO:0017144,GO:0019265,GO:0019752,GO:0040007,GO:0042133,GO:0042136,GO:0042579,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0065007,GO:0065008,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.6.1.52	ko:K00831	ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230	M00020,M00124	R04173,R05085	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_5
HKD2_k127_5165549_0	106370.Francci3_0081	1.432e-199	628.0	COG0372@1|root,COG0372@2|Bacteria,2GKST@201174|Actinobacteria,4ES17@85013|Frankiales	201174|Actinobacteria	C	Belongs to the citrate synthase family	citA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
HKD2_k127_5165549_1	656024.FsymDg_0250	1.352e-88	298.0	COG0259@1|root,COG0259@2|Bacteria,2GJCR@201174|Actinobacteria,4ESKJ@85013|Frankiales	201174|Actinobacteria	H	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP)	pdxH	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0010181,GO:0016491,GO:0016614,GO:0016899,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0032553,GO:0034641,GO:0036094,GO:0042364,GO:0042802,GO:0042803,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0043167,GO:0043168,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046184,GO:0046483,GO:0046983,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	1.4.3.5	ko:K00275	ko00750,ko01100,ko01120,map00750,map01100,map01120	M00124	R00277,R00278,R01710,R01711	RC00048,RC00116	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv2607	PNP_phzG_C,Putative_PNPOx
HKD2_k127_5165549_2	1032480.MLP_53290	3.441e-10	64.0	2D5EC@1|root,32TIW@2|Bacteria,2GPZ6@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5167491_1	298655.KI912267_gene6977	3.052e-72	248.0	COG0475@1|root,COG0475@2|Bacteria,2GJ69@201174|Actinobacteria,4ES2U@85013|Frankiales	201174|Actinobacteria	P	PFAM sodium hydrogen exchanger	-	-	-	ko:K03455	-	-	-	-	ko00000	2.A.37	-	-	Na_H_Exchanger
HKD2_k127_5167491_0	1122611.KB903944_gene1163	4.772e-126	419.0	COG0053@1|root,COG0053@2|Bacteria,2GJ8Q@201174|Actinobacteria,4EG8Y@85012|Streptosporangiales	201174|Actinobacteria	P	Dimerisation domain of Zinc Transporter	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,ZT_dimer
HKD2_k127_5167491_2	1184609.KILIM_117_00030	2.241e-52	202.0	COG2197@1|root,COG2197@2|Bacteria,2IBJW@201174|Actinobacteria	201174|Actinobacteria	KT	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HKD2_k127_5167491_7	1184609.KILIM_117_00040	1.643e-21	109.0	COG4585@1|root,COG4585@2|Bacteria,2IBBV@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase-like ATPases	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5167491_4	1120936.KB907210_gene5622	3.176e-32	141.0	COG4585@1|root,COG4585@2|Bacteria,2IBBV@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase-like ATPases	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5167491_6	1121924.ATWH01000009_gene110	1.628e-26	121.0	COG1848@1|root,COG1848@2|Bacteria,2GVD1@201174|Actinobacteria,4FSTH@85023|Microbacteriaceae	201174|Actinobacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
HKD2_k127_5167491_5	1089546.AQUI01000002_gene4538	2.914e-27	115.0	293XG@1|root,2ZRCJ@2|Bacteria,2HA8D@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	RHH_1
HKD2_k127_5167491_8	222534.KB893759_gene4030	2.242e-05	48.0	COG1514@1|root,COG1514@2|Bacteria,2IFYV@201174|Actinobacteria	201174|Actinobacteria	J	2'-5' RNA ligase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	2_5_RNA_ligase2
HKD2_k127_5171790_3	1123320.KB889681_gene2594	1.54e-40	170.0	COG1063@1|root,COG1063@2|Bacteria,2GKC7@201174|Actinobacteria	201174|Actinobacteria	E	alcohol dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
HKD2_k127_5171790_2	1123320.KB889681_gene2586	4.189e-85	310.0	COG1830@1|root,COG1830@2|Bacteria,2IB09@201174|Actinobacteria	201174|Actinobacteria	G	Aldolase	griI	-	2.3.1.245,4.1.2.13,4.1.2.56	ko:K08321,ko:K11645,ko:K18287	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko02024,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map02024	M00001,M00003	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	DeoC
HKD2_k127_5171790_0	1123320.KB889681_gene2596	2.493e-158	513.0	COG1012@1|root,COG1012@2|Bacteria,2GIWZ@201174|Actinobacteria	201174|Actinobacteria	C	Belongs to the aldehyde dehydrogenase family	-	-	1.2.1.3,1.2.1.8,1.2.1.98	ko:K00128,ko:K00130,ko:K20928	ko00010,ko00053,ko00071,ko00260,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00260,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135,M00555	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02565,R02566,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
HKD2_k127_5171790_1	1313172.YM304_42220	4.238e-99	341.0	COG4638@1|root,COG4638@2|Bacteria,2GKJY@201174|Actinobacteria	201174|Actinobacteria	P	Rieske 2Fe-2S	-	-	-	ko:K00479	-	-	-	-	ko00000	-	-	-	Rieske,Ring_hydroxyl_A
HKD2_k127_5171790_4	298655.KI912267_gene7898	1.213e-29	132.0	COG1744@1|root,COG1744@2|Bacteria,2GKJZ@201174|Actinobacteria	201174|Actinobacteria	S	ABC transporter substrate-binding protein PnrA-like	-	-	-	ko:K07335	-	-	-	-	ko00000	-	-	-	Bmp
HKD2_k127_5177144_29	1123024.AUII01000054_gene3168	2.437e-24	108.0	COG3293@1|root,COG3293@2|Bacteria,2ICBV@201174|Actinobacteria,4EB0I@85010|Pseudonocardiales	201174|Actinobacteria	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_2,DUF4096
HKD2_k127_5177144_37	330084.JNYZ01000003_gene2077	4.62e-06	48.0	COG3293@1|root,COG3293@2|Bacteria,2ICBV@201174|Actinobacteria,4EB0I@85010|Pseudonocardiales	201174|Actinobacteria	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_2,DUF4096
HKD2_k127_5177144_33	665577.JH993790_gene5867	4.248e-18	88.0	COG2801@1|root,COG2801@2|Bacteria,2GKDY@201174|Actinobacteria	201174|Actinobacteria	L	PFAM Integrase catalytic	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve,rve_3
HKD2_k127_5177144_2	656024.FsymDg_3146	9.278e-187	588.0	COG0205@1|root,COG0205@2|Bacteria,2GK6W@201174|Actinobacteria,4ERH0@85013|Frankiales	201174|Actinobacteria	G	Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions	pfp	-	2.7.1.11,2.7.1.90	ko:K00850,ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230	M00001,M00345	R00756,R00764,R02073,R03236,R03237,R03238,R03239,R04779	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000,ko01009,ko03019	-	-	-	PFK
HKD2_k127_5177144_14	710111.FraQA3DRAFT_5935	3.062e-109	362.0	COG3266@1|root,COG3266@2|Bacteria,2I44K@201174|Actinobacteria,4ERQA@85013|Frankiales	201174|Actinobacteria	S	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5177144_0	365528.KB891203_gene3417	7.623e-239	743.0	COG3200@1|root,COG3200@2|Bacteria,2GJBX@201174|Actinobacteria,4ES2A@85013|Frankiales	201174|Actinobacteria	E	Belongs to the class-II DAHP synthase family	aroG	GO:0003674,GO:0003824,GO:0003849,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016020,GO:0016043,GO:0016053,GO:0016740,GO:0016765,GO:0019752,GO:0022607,GO:0030145,GO:0030312,GO:0040007,GO:0043167,GO:0043169,GO:0043436,GO:0043648,GO:0043650,GO:0043933,GO:0044085,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0046872,GO:0046914,GO:0051259,GO:0051260,GO:0065003,GO:0071704,GO:0071840,GO:0071944,GO:1901576	2.5.1.54	ko:K01626,ko:K16019	ko00400,ko01051,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01051,map01100,map01110,map01130,map01230,map02024	M00022	R01826,R06591	RC00435,RC01556	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv2178c	DAHP_synth_2
HKD2_k127_5177144_10	219305.MCAG_01247	1.614e-126	440.0	COG2008@1|root,COG2008@2|Bacteria,2GMNV@201174|Actinobacteria,4DAY8@85008|Micromonosporales	201174|Actinobacteria	E	Threonine aldolase	ltaA	-	4.1.2.48	ko:K01620	ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230	-	R00751,R06171	RC00312,RC00372	ko00000,ko00001,ko01000	-	-	-	Beta_elim_lyase
HKD2_k127_5177144_7	1206101.AZXC01000002_gene5956	1.106e-142	474.0	COG0515@1|root,COG2815@1|root,COG0515@2|Bacteria,COG2815@2|Bacteria,2GJ1J@201174|Actinobacteria	201174|Actinobacteria	KLT	serine threonine protein kinase	pknL	GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018107,GO:0018193,GO:0018210,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0036211,GO:0042304,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046777,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0140096,GO:1901564	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
HKD2_k127_5177144_16	1120936.KB907218_gene3321	8.669e-84	293.0	COG0111@1|root,COG0111@2|Bacteria,2GKTT@201174|Actinobacteria,4EHSN@85012|Streptosporangiales	201174|Actinobacteria	EH	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain	-	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
HKD2_k127_5177144_12	298655.KI912267_gene7386	2.724e-121	394.0	COG2022@1|root,COG2022@2|Bacteria,2GM62@201174|Actinobacteria,4ES56@85013|Frankiales	201174|Actinobacteria	H	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S	thiG	-	2.8.1.10	ko:K03149	ko00730,ko01100,map00730,map01100	-	R10247	RC03096,RC03097,RC03461	ko00000,ko00001,ko01000	-	-	-	ThiG
HKD2_k127_5177144_3	106370.Francci3_3075	5.297e-173	565.0	COG0502@1|root,COG0502@2|Bacteria,2IKFZ@201174|Actinobacteria	201174|Actinobacteria	C	Biotin and Thiamin Synthesis associated	thiH	-	4.1.99.19	ko:K03150	ko00730,ko01100,map00730,map01100	-	R10246	RC01434,RC03095	ko00000,ko00001,ko01000	-	-	-	BATS,Radical_SAM
HKD2_k127_5177144_5	106370.Francci3_3074	3.901e-143	483.0	COG0446@1|root,COG0446@2|Bacteria,2GJKT@201174|Actinobacteria	201174|Actinobacteria	Q	pyridine nucleotide-disulphide oxidoreductase	fprE	-	1.18.1.3	ko:K00529	ko00071,ko00360,ko01120,ko01220,map00071,map00360,map01120,map01220	M00545	R02000,R06782,R06783	RC00098	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	Pyr_redox_2,Reductase_C
HKD2_k127_5177144_21	1489678.RDMS_13650	5.306e-49	188.0	COG0673@1|root,COG0673@2|Bacteria,1WJSV@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	PFAM Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
HKD2_k127_5177144_22	656024.FsymDg_3140	4.024e-48	179.0	2E0H9@1|root,32W34@2|Bacteria,2IHPW@201174|Actinobacteria,4ETAN@85013|Frankiales	201174|Actinobacteria	S	transcriptional regulator	-	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010565,GO:0016310,GO:0018107,GO:0018193,GO:0018210,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0031323,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0050789,GO:0050794,GO:0062012,GO:0065007,GO:0071704,GO:0080090,GO:0097159,GO:1901363,GO:1901564	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5177144_27	1463825.JNXC01000012_gene1778	2.336e-33	134.0	COG3871@1|root,COG3871@2|Bacteria,2I2QZ@201174|Actinobacteria,4E4E6@85010|Pseudonocardiales	201174|Actinobacteria	S	Pyridoxamine 5'-phosphate oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
HKD2_k127_5177144_17	656024.FsymDg_3139	3.98e-83	284.0	COG0352@1|root,COG0352@2|Bacteria,2GKCN@201174|Actinobacteria,4EVSD@85013|Frankiales	201174|Actinobacteria	H	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)	thiE	GO:0003674,GO:0003824,GO:0004789,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.3	ko:K00788	ko00730,ko01100,map00730,map01100	M00127	R03223,R10712	RC00224,RC03255,RC03397	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv0414c	TMP-TENI
HKD2_k127_5177144_24	326424.FRAAL5074	2.494e-46	177.0	2CPEY@1|root,32SIY@2|Bacteria,2I84R@201174|Actinobacteria,4ETKH@85013|Frankiales	201174|Actinobacteria	S	lycopene cyclase	crtY	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5177144_28	298653.Franean1_1844	3.834e-32	138.0	2E9MI@1|root,333U6@2|Bacteria,2IMX9@201174|Actinobacteria,4ETA1@85013|Frankiales	201174|Actinobacteria	S	lycopene cyclase domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5177144_31	1380356.JNIK01000017_gene2916	2.623e-19	96.0	COG1848@1|root,COG1848@2|Bacteria,2IQB5@201174|Actinobacteria,4EWKW@85013|Frankiales	201174|Actinobacteria	S	PIN domain	-	-	-	ko:K07064	-	-	-	-	ko00000	-	-	-	PIN
HKD2_k127_5177144_30	1313172.YM304_01250	8.823e-20	97.0	COG4118@1|root,COG4118@2|Bacteria	2|Bacteria	D	positive regulation of growth	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
HKD2_k127_5177144_9	222534.KB893671_gene3256	6.042e-131	427.0	COG1562@1|root,COG1562@2|Bacteria,2GJN2@201174|Actinobacteria,4ESHS@85013|Frankiales	201174|Actinobacteria	I	Phytoene synthase	crtB	-	2.5.1.32,2.5.1.99	ko:K02291	ko00906,ko01062,ko01100,ko01110,map00906,map01062,map01100,map01110	M00097	R02065,R04218,R07270,R10177	RC00362,RC01101,RC02869	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	SQS_PSY
HKD2_k127_5177144_8	298653.Franean1_5131	8.234e-139	453.0	COG2304@1|root,COG2304@2|Bacteria,2GNKP@201174|Actinobacteria,4ERIY@85013|Frankiales	201174|Actinobacteria	S	PFAM von Willebrand factor type A	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	BatA,VWA_2
HKD2_k127_5177144_11	298653.Franean1_5130	3.631e-122	425.0	COG1721@1|root,COG1721@2|Bacteria,2GKSJ@201174|Actinobacteria,4ES3V@85013|Frankiales	201174|Actinobacteria	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58,Ery_res_leader1
HKD2_k127_5177144_4	298653.Franean1_5129	4.901e-162	519.0	COG0714@1|root,COG0714@2|Bacteria,2GK07@201174|Actinobacteria,4ERGM@85013|Frankiales	201174|Actinobacteria	S	PFAM ATPase associated with various cellular activities	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
HKD2_k127_5177144_15	1048339.KB913029_gene1627	8.239e-101	334.0	COG3423@1|root,COG3423@2|Bacteria,2GP2G@201174|Actinobacteria,4EV3U@85013|Frankiales	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5177144_19	356851.JOAN01000030_gene5039	1.066e-65	230.0	COG1051@1|root,COG1051@2|Bacteria,2I8YY@201174|Actinobacteria,4DDIN@85008|Micromonosporales	201174|Actinobacteria	F	Belongs to the Nudix hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
HKD2_k127_5177144_26	263358.VAB18032_01610	8.36e-36	139.0	COG1418@1|root,COG1418@2|Bacteria,2IAVS@201174|Actinobacteria,4DF0M@85008|Micromonosporales	201174|Actinobacteria	S	phosphohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HD
HKD2_k127_5177144_35	263358.VAB18032_01610	1.551e-12	72.0	COG1418@1|root,COG1418@2|Bacteria,2IAVS@201174|Actinobacteria,4DF0M@85008|Micromonosporales	201174|Actinobacteria	S	phosphohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HD
HKD2_k127_5177144_36	28377.ENSACAP00000022557	1.723e-06	55.0	COG1618@1|root,2QVJ8@2759|Eukaryota,38FT1@33154|Opisthokonta,3BGUB@33208|Metazoa,3CSDG@33213|Bilateria,482RA@7711|Chordata,493VV@7742|Vertebrata	33208|Metazoa	O	nucleotide phosphatase activity, acting on free nucleotides	NTPCR	-	3.6.1.15	ko:K06928	ko00230,ko00730,ko01100,map00230,map00730,map01100	-	R00086,R00615	RC00002	ko00000,ko00001,ko01000	-	-	-	NTPase_1
HKD2_k127_5177144_25	1155714.KB891987_gene2553	7.237e-42	161.0	COG0758@1|root,COG0758@2|Bacteria,2IKR2@201174|Actinobacteria	201174|Actinobacteria	LU	DNA mediated transformation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5177144_34	33876.JNXY01000009_gene8913	1.314e-16	90.0	2BRMR@1|root,32KM5@2|Bacteria,2HX0A@201174|Actinobacteria,4DKVP@85008|Micromonosporales	201174|Actinobacteria	S	Bacterial antitoxin of type II TA system, VapB	-	-	-	-	-	-	-	-	-	-	-	-	VapB_antitoxin
HKD2_k127_5177144_1	326424.FRAAL2160	4.532e-237	741.0	COG1233@1|root,COG1233@2|Bacteria,2GJAV@201174|Actinobacteria,4ERGK@85013|Frankiales	201174|Actinobacteria	Q	Phytoene desaturase	crtI	-	1.3.99.26,1.3.99.28,1.3.99.29,1.3.99.31	ko:K10027	ko00906,ko01100,ko01110,map00906,map01100,map01110	-	R04787,R04798,R04800,R09691,R09692	RC01214,RC02088,RC02605	ko00000,ko00001,ko01000	-	-	-	Amino_oxidase
HKD2_k127_5177144_13	1123320.KB889675_gene3878	1.927e-118	398.0	COG0142@1|root,COG0142@2|Bacteria,2GJEK@201174|Actinobacteria	201174|Actinobacteria	H	Belongs to the FPP GGPP synthase family	idsA	-	2.5.1.1,2.5.1.10,2.5.1.29	ko:K13787	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00365	R01658,R02003,R02061	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
HKD2_k127_5177144_23	656024.FsymDg_3131	9.302e-48	183.0	COG3595@1|root,COG3595@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF2807,DUF4097
HKD2_k127_5177144_6	298653.Franean1_5126	4.654e-143	458.0	COG0685@1|root,COG0685@2|Bacteria,2GJTN@201174|Actinobacteria,4ERKZ@85013|Frankiales	201174|Actinobacteria	E	Methylenetetrahydrofolate reductase	metF	-	1.5.1.20	ko:K00297	ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523	M00377	R01224,R07168	RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	MTHFR
HKD2_k127_5177144_18	326424.FRAAL2165	7.036e-70	252.0	COG0558@1|root,COG0558@2|Bacteria,2IDSP@201174|Actinobacteria,4ET6D@85013|Frankiales	201174|Actinobacteria	I	CDP-alcohol phosphatidyltransferase	-	-	2.7.8.5	ko:K00995	ko00564,ko01100,map00564,map01100	-	R01801	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
HKD2_k127_5177144_20	66429.JOFL01000005_gene3726	9.154e-52	192.0	COG0652@1|root,COG0652@2|Bacteria,2GN8G@201174|Actinobacteria	201174|Actinobacteria	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	ppiB	-	5.2.1.8	ko:K03768	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Pro_isomerase
HKD2_k127_5186551_3	106370.Francci3_4370	5.664e-58	209.0	COG0151@1|root,COG0151@2|Bacteria,2I2F5@201174|Actinobacteria,4ERHW@85013|Frankiales	201174|Actinobacteria	F	Belongs to the GARS family	purD	GO:0008150,GO:0040007	6.3.3.1,6.3.4.13	ko:K01945,ko:K11788	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144,R04208	RC00090,RC00166,RC01100	ko00000,ko00001,ko00002,ko01000	-	-	-	GARS_A,GARS_C,GARS_N
HKD2_k127_5186551_7	656024.FsymDg_2712	1.663e-21	96.0	COG2002@1|root,COG2002@2|Bacteria,2H0G1@201174|Actinobacteria	201174|Actinobacteria	K	toxin-antitoxin pair type II binding	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5186551_0	656024.FsymDg_4384	9.817e-237	737.0	COG0104@1|root,COG0104@2|Bacteria,2GMP4@201174|Actinobacteria,4ERUX@85013|Frankiales	201174|Actinobacteria	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0040007,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
HKD2_k127_5186551_2	298653.Franean1_0213	5.198e-72	257.0	COG3409@1|root,COG3409@2|Bacteria,2HKP4@201174|Actinobacteria,4EVKS@85013|Frankiales	201174|Actinobacteria	M	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Transglycosylas
HKD2_k127_5186551_1	1125971.ASJB01000031_gene1284	3.555e-146	470.0	COG1830@1|root,COG1830@2|Bacteria,2HPYY@201174|Actinobacteria,4E70X@85010|Pseudonocardiales	201174|Actinobacteria	G	Aldolase	-	-	4.1.2.13	ko:K11645	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	DeoC
HKD2_k127_5186551_4	298654.FraEuI1c_0203	8.605e-54	200.0	COG3409@1|root,COG3409@2|Bacteria,2ICQE@201174|Actinobacteria	201174|Actinobacteria	M	Transglycosylase-like domain	-	-	-	ko:K21687	-	-	-	-	ko00000	-	GH23	-	PG_binding_1,Transglycosylas
HKD2_k127_5188892_13	656024.FsymDg_3234	1.052e-17	82.0	COG0174@1|root,COG0174@2|Bacteria,2GJ2I@201174|Actinobacteria,4ERGV@85013|Frankiales	201174|Actinobacteria	E	PFAM Glutamine synthetase, catalytic	glnA2	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0016787,GO:0016810,GO:0016811,GO:0044464,GO:0050001,GO:0071944	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
HKD2_k127_5188892_0	2002.JOEQ01000030_gene2092	2.243e-320	1009.0	COG1391@1|root,COG1391@2|Bacteria,2GJ91@201174|Actinobacteria,4EFGN@85012|Streptosporangiales	201174|Actinobacteria	OT	Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell	glnE	GO:0000820,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006521,GO:0008150,GO:0008882,GO:0010565,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0019222,GO:0030312,GO:0031323,GO:0033238,GO:0040007,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0060359,GO:0062012,GO:0065007,GO:0070566,GO:0071944,GO:0080090,GO:1901698	2.7.7.42,2.7.7.89	ko:K00982	-	-	-	-	ko00000,ko01000	-	-	-	GlnD_UR_UTase,GlnE
HKD2_k127_5188892_12	1123023.JIAI01000005_gene880	3.007e-23	111.0	COG0596@1|root,COG0596@2|Bacteria,2GJCT@201174|Actinobacteria,4DZI3@85010|Pseudonocardiales	201174|Actinobacteria	S	Alpha/beta hydrolase family	-	-	3.8.1.3	ko:K01561	ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120	-	R05287	RC00697	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1
HKD2_k127_5188892_9	66373.JOFQ01000007_gene3392	5.664e-68	244.0	COG0671@1|root,COG0671@2|Bacteria,2GMYU@201174|Actinobacteria	201174|Actinobacteria	I	PAP2 superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PAP2_3
HKD2_k127_5188892_1	298653.Franean1_1770	1.047e-271	841.0	COG0174@1|root,COG0174@2|Bacteria,2GMN1@201174|Actinobacteria,4ES5H@85013|Frankiales	201174|Actinobacteria	E	TIGRFAM glutamine synthetase, type I	glnA	GO:0001968,GO:0003674,GO:0003824,GO:0004356,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006541,GO:0006542,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009405,GO:0009605,GO:0009607,GO:0009893,GO:0009987,GO:0010468,GO:0010604,GO:0010628,GO:0010755,GO:0010756,GO:0010954,GO:0016020,GO:0016053,GO:0016211,GO:0016874,GO:0016879,GO:0016880,GO:0019222,GO:0019752,GO:0019899,GO:0020012,GO:0030162,GO:0030312,GO:0030682,GO:0031323,GO:0031325,GO:0032268,GO:0032270,GO:0035375,GO:0040007,GO:0043207,GO:0043436,GO:0044044,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0045862,GO:0046394,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0051701,GO:0051704,GO:0051707,GO:0051805,GO:0051807,GO:0051832,GO:0051834,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0060255,GO:0065007,GO:0070613,GO:0071704,GO:0071944,GO:0075136,GO:0080090,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1903317,GO:1903319	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
HKD2_k127_5188892_10	710111.FraQA3DRAFT_6369	1.43e-60	214.0	COG1714@1|root,COG1714@2|Bacteria,2IQMG@201174|Actinobacteria,4ETM3@85013|Frankiales	201174|Actinobacteria	S	RDD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	RDD
HKD2_k127_5188892_6	710111.FraQA3DRAFT_6370	2.41e-95	318.0	2AUFS@1|root,31K3Y@2|Bacteria,2GIXC@201174|Actinobacteria,4ESQ4@85013|Frankiales	201174|Actinobacteria	S	Domain of unknown function (DUF4191)	-	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DUF4191
HKD2_k127_5188892_2	1150864.MILUP08_45266	8.124e-162	525.0	COG0320@1|root,COG0320@2|Bacteria,2GKD4@201174|Actinobacteria,4D8DS@85008|Micromonosporales	201174|Actinobacteria	H	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives	lipA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0016740,GO:0016782,GO:0016783,GO:0016992,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0070283,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576	2.8.1.8	ko:K03644	ko00785,ko01100,map00785,map01100	-	R07767,R07768	RC01978	ko00000,ko00001,ko01000	-	-	-	LIAS_N,Radical_SAM
HKD2_k127_5188892_7	710111.FraQA3DRAFT_6373	7.618e-89	309.0	COG0321@1|root,COG0321@2|Bacteria,2GJIX@201174|Actinobacteria,4ES92@85013|Frankiales	201174|Actinobacteria	H	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate	lipB	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016020,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0033819,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0071704,GO:0071944,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576	2.3.1.181	ko:K03801	ko00785,ko01100,map00785,map01100	-	R07766,R07769	RC00039,RC00992,RC02867	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB
HKD2_k127_5188892_3	365528.KB891223_gene1326	2.398e-114	393.0	COG3340@1|root,COG3340@2|Bacteria,2GZK5@201174|Actinobacteria,4EUBC@85013|Frankiales	201174|Actinobacteria	E	Belongs to the peptidase S51 family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S51
HKD2_k127_5188892_5	479432.Sros_5634	3.686e-105	361.0	COG1233@1|root,COG1233@2|Bacteria,2I3VB@201174|Actinobacteria,4ER4A@85012|Streptosporangiales	201174|Actinobacteria	Q	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
HKD2_k127_5188892_8	656024.FsymDg_3221	4.259e-79	287.0	COG0515@1|root,COG0515@2|Bacteria	656024.FsymDg_3221|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5188892_4	656024.FsymDg_3220	1.967e-113	377.0	COG1090@1|root,COG1090@2|Bacteria,2GJS0@201174|Actinobacteria,4ERYV@85013|Frankiales	201174|Actinobacteria	S	epimerase dehydratase	-	-	-	ko:K07071	-	-	-	-	ko00000	-	-	-	DUF1731,Epimerase
HKD2_k127_5188892_11	298654.FraEuI1c_1768	3.577e-55	194.0	COG0508@1|root,COG0508@2|Bacteria,2GMUV@201174|Actinobacteria,4ERCG@85013|Frankiales	201174|Actinobacteria	C	TIGRFAM 2-oxoglutarate dehydrogenase, E2 component	sucB	-	2.3.1.61	ko:K00658	ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R02570,R02571,R08549	RC00004,RC02727,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
HKD2_k127_5193623_0	526225.Gobs_4005	2.748e-90	304.0	COG0336@1|root,COG0336@2|Bacteria,2GJ1G@201174|Actinobacteria,4ERT5@85013|Frankiales	201174|Actinobacteria	J	Belongs to the RNA methyltransferase TrmD family	trmD	GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050518,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.1.1.228	ko:K00554	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	Acetyltransf_1,tRNA_m1G_MT
HKD2_k127_5193623_3	656024.FsymDg_3674	9.405e-50	183.0	COG0806@1|root,COG0806@2|Bacteria,2GK4I@201174|Actinobacteria,4ET25@85013|Frankiales	201174|Actinobacteria	J	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes	rimM	GO:0008150,GO:0040007	-	ko:K02860	-	-	-	-	ko00000,ko03009	-	-	-	PRC,RimM
HKD2_k127_5193623_4	656024.FsymDg_3675	8.783e-34	130.0	COG1837@1|root,COG1837@2|Bacteria,2IQ4C@201174|Actinobacteria,4ETC9@85013|Frankiales	201174|Actinobacteria	S	Belongs to the UPF0109 family	-	GO:0008150,GO:0040007	-	ko:K06960	-	-	-	-	ko00000	-	-	-	KH_4
HKD2_k127_5193623_2	326424.FRAAL5792	1.43e-56	209.0	COG0228@1|root,COG0228@2|Bacteria,2IKU0@201174|Actinobacteria,4ESVE@85013|Frankiales	201174|Actinobacteria	J	Belongs to the bacterial ribosomal protein bS16 family	rpsP	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02959	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S16
HKD2_k127_5193623_1	656024.FsymDg_3677	3.14e-84	284.0	COG0541@1|root,COG0541@2|Bacteria,2GK4R@201174|Actinobacteria,4ERD5@85013|Frankiales	201174|Actinobacteria	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY	ffh	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
HKD2_k127_5284728_6	1382306.JNIM01000001_gene1634	3.42e-25	108.0	COG0174@1|root,COG0174@2|Bacteria,2G62E@200795|Chloroflexi	200795|Chloroflexi	E	Glutamine synthetase N-terminal domain	-	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N_2
HKD2_k127_5284728_3	1382356.JQMP01000003_gene2130	2.106e-55	213.0	COG2159@1|root,COG2159@2|Bacteria,2G6EZ@200795|Chloroflexi,27YN4@189775|Thermomicrobia	189775|Thermomicrobia	S	Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
HKD2_k127_5284728_0	298653.Franean1_7278	1.922e-216	709.0	COG0457@1|root,COG2114@1|root,COG3899@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG3899@2|Bacteria,2GJRI@201174|Actinobacteria,4ETX1@85013|Frankiales	201174|Actinobacteria	T	PFAM Adenylyl cyclase class-3 4 guanylyl cyclase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,DZR,Guanylate_cyc,TPR_12
HKD2_k127_5284728_4	479434.Sthe_0323	1.566e-31	144.0	COG4485@1|root,COG4485@2|Bacteria,2G75F@200795|Chloroflexi,27XT2@189775|Thermomicrobia	189775|Thermomicrobia	S	Bacterial membrane protein YfhO	-	-	-	-	-	-	-	-	-	-	-	-	YfhO
HKD2_k127_5284728_7	1236902.ANAS01000040_gene5009	4.757e-21	95.0	COG1473@1|root,COG1473@2|Bacteria,2GK05@201174|Actinobacteria,4EFIW@85012|Streptosporangiales	201174|Actinobacteria	S	Peptidase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
HKD2_k127_5284728_8	1323361.JPOC01000069_gene1413	7.432e-12	78.0	COG1473@1|root,COG1473@2|Bacteria,2GK05@201174|Actinobacteria,4FUVX@85025|Nocardiaceae	201174|Actinobacteria	S	Peptidase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
HKD2_k127_5284728_1	68570.DC74_552	3.538e-105	360.0	COG1473@1|root,COG1473@2|Bacteria,2GK05@201174|Actinobacteria	201174|Actinobacteria	M	amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
HKD2_k127_5284728_5	675635.Psed_1388	2.275e-29	121.0	COG1917@1|root,COG1917@2|Bacteria,2IP0F@201174|Actinobacteria,4E781@85010|Pseudonocardiales	201174|Actinobacteria	S	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5284728_2	1123023.JIAI01000003_gene3051	1.608e-57	211.0	COG1090@1|root,COG1090@2|Bacteria,2I3Q5@201174|Actinobacteria,4EEAQ@85010|Pseudonocardiales	201174|Actinobacteria	S	NmrA-like family	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase,NAD_binding_10
HKD2_k127_5288396_3	106370.Francci3_0557	9.635e-139	471.0	COG0501@1|root,COG0501@2|Bacteria,2GMJF@201174|Actinobacteria,4ESBZ@85013|Frankiales	201174|Actinobacteria	O	Belongs to the peptidase M48B family	htpX	GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
HKD2_k127_5288396_4	58123.JOFJ01000002_gene2678	4.306e-134	444.0	COG1007@1|root,COG1007@2|Bacteria,2GMGX@201174|Actinobacteria,4EGIZ@85012|Streptosporangiales	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoN2	-	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
HKD2_k127_5288396_0	1120936.KB907214_gene4543	8.582e-178	572.0	COG1008@1|root,COG1008@2|Bacteria,2GKBN@201174|Actinobacteria,4EI1F@85012|Streptosporangiales	201174|Actinobacteria	C	Proton-conducting membrane transporter	nuoM2	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
HKD2_k127_5288396_1	1120950.KB892779_gene932	2.812e-162	531.0	COG1009@1|root,COG1009@2|Bacteria,2GIT4@201174|Actinobacteria,4DT5U@85009|Propionibacteriales	201174|Actinobacteria	CP	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus	nuoL2	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M,Proton_antipo_N
HKD2_k127_5288396_9	1463864.JOGO01000020_gene3444	4.065e-37	143.0	COG0713@1|root,COG0713@2|Bacteria,2IHNW@201174|Actinobacteria	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoK2	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0050136,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204	1.6.5.3	ko:K00340	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q2
HKD2_k127_5288396_8	2002.JOEQ01000050_gene8388	2.311e-48	182.0	COG0839@1|root,COG0839@2|Bacteria,2GJB7@201174|Actinobacteria,4EIJM@85012|Streptosporangiales	201174|Actinobacteria	C	NADH-ubiquinone/plastoquinone oxidoreductase chain 6	nuoJ2	-	1.6.5.3	ko:K00339,ko:K05578	ko00190,ko01100,map00190,map01100	M00144,M00145	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q3
HKD2_k127_5288396_6	1449353.JQMQ01000005_gene3554	3.453e-77	287.0	COG1143@1|root,COG1143@2|Bacteria,2GPSS@201174|Actinobacteria,2NG5P@228398|Streptacidiphilus	201174|Actinobacteria	C	4Fe-4S dicluster domain	nuoI2	-	1.6.5.3	ko:K00338	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer4
HKD2_k127_5288396_2	1122182.KB903813_gene2355	5.209e-143	474.0	COG1005@1|root,COG1005@2|Bacteria,2GN3R@201174|Actinobacteria,4DB5M@85008|Micromonosporales	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	nuoH2	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
HKD2_k127_5288396_7	471852.Tcur_4386	3.626e-66	232.0	COG0852@1|root,COG0852@2|Bacteria,2GNVP@201174|Actinobacteria,4EIQ6@85012|Streptosporangiales	201174|Actinobacteria	C	Respiratory-chain NADH dehydrogenase, 30 Kd subunit	nuoC2	-	1.6.5.3	ko:K00332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa
HKD2_k127_5288396_5	1120936.KB907214_gene4552	2.7e-78	263.0	COG0377@1|root,COG0377@2|Bacteria,2GJP5@201174|Actinobacteria,4EHDU@85012|Streptosporangiales	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoB2	-	1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q6
HKD2_k127_5308029_3	1150864.MILUP08_45860	2.236e-237	747.0	COG0591@1|root,COG0591@2|Bacteria,2GKPW@201174|Actinobacteria,4D977@85008|Micromonosporales	201174|Actinobacteria	E	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	-	-	-	ko:K03307	-	-	-	-	ko00000	2.A.21	-	-	SSF
HKD2_k127_5308029_6	1120949.KB903357_gene4818	1.659e-165	529.0	COG2723@1|root,COG2723@2|Bacteria,2GJAF@201174|Actinobacteria	201174|Actinobacteria	G	Belongs to the glycosyl hydrolase 1 family	-	-	3.2.1.21	ko:K05350	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_1
HKD2_k127_5308029_1	106370.Francci3_3637	1.407e-256	799.0	COG1052@1|root,COG1052@2|Bacteria,2I2RK@201174|Actinobacteria,4ERV1@85013|Frankiales	201174|Actinobacteria	E	D-isomer specific 2-hydroxyacid dehydrogenase	serA	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C,ACT
HKD2_k127_5308029_4	656024.FsymDg_3760	4.902e-182	573.0	COG0059@1|root,COG0059@2|Bacteria,2GKXA@201174|Actinobacteria,4ES1H@85013|Frankiales	201174|Actinobacteria	EH	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate	ilvC	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0008152,GO:0008677,GO:0016020,GO:0016491,GO:0016614,GO:0016616,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0071944	1.1.1.86	ko:K00053	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R03051,R04439,R04440,R05068,R05069,R05071	RC00726,RC00836,RC00837,RC01726	ko00000,ko00001,ko00002,ko01000	-	-	-	IlvC,IlvN
HKD2_k127_5308029_8	656024.FsymDg_3761	1.126e-76	285.0	COG0440@1|root,COG0440@2|Bacteria,2GJCH@201174|Actinobacteria,4ESEU@85013|Frankiales	201174|Actinobacteria	E	Acetolactate synthase, small subunit	ilvN	GO:0003674,GO:0003824,GO:0003984,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005948,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016744,GO:0019752,GO:0030312,GO:0032991,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494,GO:1990234	2.2.1.6	ko:K01653	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,ACT_5,ALS_ss_C
HKD2_k127_5308029_0	710111.FraQA3DRAFT_5744	0.0	1046.0	COG0028@1|root,COG0028@2|Bacteria,2GKU4@201174|Actinobacteria,4ES0H@85013|Frankiales	201174|Actinobacteria	E	TIGRFAM Acetolactate synthase, large subunit, biosynthetic	ilvB	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
HKD2_k127_5308029_7	65497.JODV01000024_gene1971	1.78e-102	339.0	COG3340@1|root,COG3340@2|Bacteria,2GZK5@201174|Actinobacteria,4DZJS@85010|Pseudonocardiales	201174|Actinobacteria	E	Peptidase family S51	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S51
HKD2_k127_5308029_11	65497.JODV01000024_gene1972	7.345e-14	72.0	COG1396@1|root,COG1396@2|Bacteria,2H4XQ@201174|Actinobacteria	201174|Actinobacteria	K	sequence-specific DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	HTH_31
HKD2_k127_5308029_5	106370.Francci3_3641	1.296e-169	549.0	COG0768@1|root,COG0768@2|Bacteria,2GJAM@201174|Actinobacteria,4ES9M@85013|Frankiales	201174|Actinobacteria	M	PFAM penicillin-binding protein transpeptidase	-	-	-	-	-	-	-	-	-	-	-	-	MecA_N,PBP_dimer,Transpeptidase
HKD2_k127_5308029_2	526225.Gobs_4076	1.446e-255	814.0	COG0129@1|root,COG0129@2|Bacteria,2GJIJ@201174|Actinobacteria,4ERXY@85013|Frankiales	201174|Actinobacteria	EG	Belongs to the IlvD Edd family	ilvD	GO:0003674,GO:0003824,GO:0004160,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009987,GO:0016020,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0019752,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
HKD2_k127_5308029_12	1449353.JQMQ01000005_gene2882	2.669e-11	78.0	COG3595@1|root,COG3595@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4097
HKD2_k127_5308029_9	1157640.AQWO01000005_gene2179	1.364e-37	150.0	COG0515@1|root,COG0515@2|Bacteria,2I34D@201174|Actinobacteria	201174|Actinobacteria	KLT	serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5308029_10	222534.KB893683_gene1170	1.574e-35	147.0	COG0515@1|root,COG2319@1|root,COG0515@2|Bacteria,COG2319@2|Bacteria,2GIV0@201174|Actinobacteria,4EX1X@85013|Frankiales	201174|Actinobacteria	KLT	Serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase,WD40
HKD2_k127_5343678_3	106370.Francci3_1423	1.802e-90	308.0	COG3599@1|root,COG3599@2|Bacteria,2GMSC@201174|Actinobacteria,4ET2B@85013|Frankiales	201174|Actinobacteria	D	PFAM DivIVA family protein	wag31	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0008360,GO:0009273,GO:0009987,GO:0016020,GO:0022603,GO:0022604,GO:0030312,GO:0031647,GO:0040007,GO:0042546,GO:0044085,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0050821,GO:0051128,GO:0060187,GO:0065007,GO:0065008,GO:0071554,GO:0071840,GO:0071944	-	-	-	-	-	-	-	-	-	-	DivIVA
HKD2_k127_5343678_7	298655.KI912266_gene5150	2.699e-30	122.0	COG0762@1|root,COG0762@2|Bacteria,2GQI1@201174|Actinobacteria	201174|Actinobacteria	S	integral membrane protein	-	-	-	ko:K02221	-	-	-	-	ko00000,ko02044	-	-	-	YGGT
HKD2_k127_5343678_6	106370.Francci3_1421	1.269e-67	233.0	COG1799@1|root,COG1799@2|Bacteria,2GNVH@201174|Actinobacteria,4ESVW@85013|Frankiales	201174|Actinobacteria	D	Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA	sepF	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K09772	-	-	-	-	ko00000,ko03036	-	-	-	SepF
HKD2_k127_5343678_5	298654.FraEuI1c_2378	7.22e-73	253.0	COG0325@1|root,COG0325@2|Bacteria,2GMRJ@201174|Actinobacteria,4ESQN@85013|Frankiales	201174|Actinobacteria	S	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis	-	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0008144,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0044464,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363	-	ko:K06997	-	-	-	-	ko00000	-	-	-	Ala_racemase_N
HKD2_k127_5343678_4	298653.Franean1_5093	8.444e-78	265.0	COG1496@1|root,COG1496@2|Bacteria,2GN1M@201174|Actinobacteria,4ESKN@85013|Frankiales	201174|Actinobacteria	S	Belongs to the multicopper oxidase YfiH RL5 family	yfiH	GO:0003674,GO:0005488,GO:0005507,GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0043167,GO:0043169,GO:0044464,GO:0046872,GO:0046914,GO:0071944	-	ko:K05810	-	-	-	-	ko00000,ko01000	-	-	-	Cu-oxidase_4
HKD2_k127_5343678_0	710111.FraQA3DRAFT_2853	1.633e-192	609.0	COG0206@1|root,COG0206@2|Bacteria,2GJWC@201174|Actinobacteria,4ERQ5@85013|Frankiales	201174|Actinobacteria	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	GO:0000166,GO:0000287,GO:0000910,GO:0000921,GO:0000935,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006996,GO:0007010,GO:0007049,GO:0008150,GO:0009987,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0022402,GO:0022607,GO:0030428,GO:0031106,GO:0032153,GO:0032155,GO:0032185,GO:0032506,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034622,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043169,GO:0043933,GO:0044085,GO:0044424,GO:0044464,GO:0045787,GO:0046872,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051258,GO:0051301,GO:0051726,GO:0065003,GO:0065007,GO:0070925,GO:0071840,GO:0071944,GO:0090529,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
HKD2_k127_5343678_1	656024.FsymDg_3102	1.855e-177	568.0	COG0773@1|root,COG0773@2|Bacteria,2I2E7@201174|Actinobacteria,4ERUC@85013|Frankiales	201174|Actinobacteria	M	Belongs to the MurCDEF family	murC	-	6.3.2.8	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R03193	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
HKD2_k127_5343678_2	656024.FsymDg_3103	1.74e-153	495.0	COG0707@1|root,COG0707@2|Bacteria,2GJEM@201174|Actinobacteria,4ERUA@85013|Frankiales	201174|Actinobacteria	M	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)	murG	-	2.4.1.227	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	-	R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011	-	GT28	-	Glyco_tran_28_C,Glyco_transf_28
HKD2_k127_5394930_0	1068978.AMETH_2563	2.683e-53	193.0	COG1846@1|root,COG1846@2|Bacteria,2GMDI@201174|Actinobacteria	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5394930_1	219305.MCAG_04172	1.27e-35	148.0	COG1672@1|root,COG1672@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,CHAT,HTH_31,N_BRCA1_IG,TIR_2
HKD2_k127_5495750_12	326424.FRAAL2170	2.41e-72	254.0	COG2324@1|root,COG2324@2|Bacteria,2IIUJ@201174|Actinobacteria,4EVC1@85013|Frankiales	201174|Actinobacteria	S	Carotenoid biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	Caroten_synth
HKD2_k127_5495750_5	710111.FraQA3DRAFT_2881	5.236e-147	488.0	COG1215@1|root,COG1215@2|Bacteria,2GJZI@201174|Actinobacteria,4ES88@85013|Frankiales	201174|Actinobacteria	M	Glycosyl transferase, family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3,Glyco_transf_21,Glycos_transf_2
HKD2_k127_5495750_7	1380390.JIAT01000010_gene4804	1.337e-136	457.0	COG2931@1|root,COG2931@2|Bacteria,2I3C7@201174|Actinobacteria	201174|Actinobacteria	Q	Animal haem peroxidase	-	-	-	-	-	-	-	-	-	-	-	-	An_peroxidase
HKD2_k127_5495750_3	326424.FRAAL2151	3.042e-203	639.0	COG1061@1|root,COG1061@2|Bacteria,2GIU5@201174|Actinobacteria,4ERPY@85013|Frankiales	201174|Actinobacteria	L	PFAM type III restriction protein res subunit	sdrA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	ResIII
HKD2_k127_5495750_16	710111.FraQA3DRAFT_2897	1.375e-55	204.0	COG1061@1|root,COG1061@2|Bacteria,2GIU5@201174|Actinobacteria,4ERPY@85013|Frankiales	201174|Actinobacteria	L	PFAM type III restriction protein res subunit	sdrA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	ResIII
HKD2_k127_5495750_11	298653.Franean1_5136	1.942e-83	287.0	COG1476@1|root,COG1476@2|Bacteria,2I56D@201174|Actinobacteria,4EVF1@85013|Frankiales	201174|Actinobacteria	K	TRANSCRIPTIONal	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5495750_17	710111.FraQA3DRAFT_2898	2.339e-55	198.0	COG1476@1|root,COG1476@2|Bacteria,2I56D@201174|Actinobacteria,4EVF1@85013|Frankiales	201174|Actinobacteria	K	TRANSCRIPTIONal	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5495750_19	106370.Francci3_1378	4.442e-32	128.0	COG1324@1|root,COG1324@2|Bacteria,2IQF1@201174|Actinobacteria	201174|Actinobacteria	P	Divalent ion tolerance protein	-	-	-	ko:K03926	-	-	-	-	ko00000	-	-	-	CutA1
HKD2_k127_5495750_20	1123023.JIAI01000012_gene9100	1.703e-27	118.0	2BZ6B@1|root,336KR@2|Bacteria,2IQEV@201174|Actinobacteria,4E7D3@85010|Pseudonocardiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5495750_0	1449976.KALB_7262	0.0	1244.0	COG0466@1|root,COG0466@2|Bacteria,2GK9D@201174|Actinobacteria,4DYVW@85010|Pseudonocardiales	201174|Actinobacteria	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
HKD2_k127_5495750_22	1120948.KB903247_gene4419	2.892e-24	107.0	COG5637@1|root,COG5637@2|Bacteria,2IKRQ@201174|Actinobacteria,4E5NM@85010|Pseudonocardiales	201174|Actinobacteria	S	Polyketide cyclase / dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
HKD2_k127_5495750_6	298655.KI912266_gene1000	1.065e-142	460.0	COG0477@1|root,COG0477@2|Bacteria,2GIUM@201174|Actinobacteria,4EUA5@85013|Frankiales	201174|Actinobacteria	EGP	drug resistance transporter, EmrB QacA subfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD2_k127_5495750_18	326424.FRAAL2366	9.025e-41	171.0	COG0477@1|root,COG0477@2|Bacteria,2GIUM@201174|Actinobacteria,4EUA5@85013|Frankiales	201174|Actinobacteria	EGP	drug resistance transporter, EmrB QacA subfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD2_k127_5495750_24	1394178.AWOO02000097_gene8174	4.095e-06	60.0	COG2197@1|root,COG2197@2|Bacteria,2GIXB@201174|Actinobacteria,4EH1S@85012|Streptosporangiales	201174|Actinobacteria	T	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HKD2_k127_5495750_21	1146883.BLASA_0946	2.608e-26	119.0	COG2197@1|root,COG2197@2|Bacteria,2GKBX@201174|Actinobacteria,4EVFA@85013|Frankiales	201174|Actinobacteria	K	Response regulator receiver	-	-	-	ko:K02479	-	-	-	-	ko00000,ko02022	-	-	-	GerE,Response_reg
HKD2_k127_5495750_1	222534.KB893671_gene3249	0.0	1189.0	COG0317@1|root,COG0317@2|Bacteria,2GJYQ@201174|Actinobacteria,4EREV@85013|Frankiales	201174|Actinobacteria	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	relA	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0008728,GO:0008893,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009259,GO:0009260,GO:0009267,GO:0009405,GO:0009605,GO:0009987,GO:0009991,GO:0015968,GO:0015969,GO:0015970,GO:0016020,GO:0016740,GO:0016772,GO:0016778,GO:0016787,GO:0016788,GO:0016794,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030145,GO:0030312,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034035,GO:0034036,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0042578,GO:0042594,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044419,GO:0044464,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0046872,GO:0046914,GO:0050896,GO:0051704,GO:0051716,GO:0055086,GO:0071496,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.7.6.5,3.1.7.2	ko:K00951,ko:K01139	ko00230,map00230	-	R00336,R00429	RC00002,RC00078	ko00000,ko00001,ko01000,ko03009	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
HKD2_k127_5495750_15	656024.FsymDg_2545	3.421e-57	221.0	COG0503@1|root,COG0503@2|Bacteria,2IM7C@201174|Actinobacteria,4ESW6@85013|Frankiales	201174|Actinobacteria	F	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis	apt	-	2.4.2.7	ko:K00759	ko00230,ko01100,map00230,map01100	-	R00190,R01229,R04378	RC00063	ko00000,ko00001,ko01000,ko04147	-	-	-	Pribosyltran
HKD2_k127_5495750_8	656024.FsymDg_2546	1.592e-132	435.0	COG0341@1|root,COG0341@2|Bacteria,2GJRS@201174|Actinobacteria,4ERCU@85013|Frankiales	201174|Actinobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secF	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944	-	ko:K03072,ko:K03074	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
HKD2_k127_5495750_2	710111.FraQA3DRAFT_2904	8.45e-208	661.0	COG0342@1|root,COG0342@2|Bacteria,2GJTT@201174|Actinobacteria,4ERTD@85013|Frankiales	201174|Actinobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944	-	ko:K03072	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
HKD2_k127_5495750_23	644283.Micau_2291	4.316e-12	78.0	COG1862@1|root,COG1862@2|Bacteria,2IQSP@201174|Actinobacteria,4DFMC@85008|Micromonosporales	201174|Actinobacteria	U	Preprotein translocase subunit	yajC	-	-	ko:K03210	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	YajC
HKD2_k127_5495750_4	222534.KB893671_gene3244	2.936e-173	562.0	COG2255@1|root,COG2255@2|Bacteria,2GJZF@201174|Actinobacteria,4ERZV@85013|Frankiales	201174|Actinobacteria	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing	ruvB	GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496	3.6.4.12	ko:K03551	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvB_C,RuvB_N
HKD2_k127_5495750_14	298654.FraEuI1c_2329	4.638e-68	246.0	COG0632@1|root,COG0632@2|Bacteria,2GN17@201174|Actinobacteria,4ESPJ@85013|Frankiales	201174|Actinobacteria	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB	ruvA	GO:0000724,GO:0000725,GO:0003674,GO:0003678,GO:0003824,GO:0004386,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0007154,GO:0008150,GO:0008152,GO:0009378,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0031668,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0071103,GO:0071496,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140097,GO:1901360	3.6.4.12	ko:K03550	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HHH_5,RuvA_C,RuvA_N
HKD2_k127_5495750_13	365528.KB891102_gene4465	2.744e-70	243.0	COG0817@1|root,COG0817@2|Bacteria,2GJI5@201174|Actinobacteria,4ESJZ@85013|Frankiales	201174|Actinobacteria	L	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group	ruvC	GO:0000725,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008821,GO:0009058,GO:0009059,GO:0009987,GO:0016787,GO:0016788,GO:0016889,GO:0016894,GO:0031297,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0045005,GO:0046483,GO:0048476,GO:0050896,GO:0051716,GO:0071704,GO:0071932,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901576	3.1.22.4	ko:K01159	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvC
HKD2_k127_5495750_9	298655.KI912266_gene5213	3.37e-131	424.0	COG0217@1|root,COG0217@2|Bacteria,2GJ4G@201174|Actinobacteria,4ES5T@85013|Frankiales	201174|Actinobacteria	K	Transcriptional regulatory protein	yebC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	-	-	-	-	-	-	-	-	-	Transcrip_reg
HKD2_k127_5495750_10	298654.FraEuI1c_2326	7.179e-94	311.0	COG0311@1|root,COG0311@2|Bacteria,2GNYG@201174|Actinobacteria,4ESCW@85013|Frankiales	201174|Actinobacteria	H	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS	pdxT	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0008614,GO:0009058,GO:0009108,GO:0009110,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016829,GO:0016840,GO:0016843,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0031668,GO:0032991,GO:0033554,GO:0034641,GO:0040007,GO:0042364,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046184,GO:0046483,GO:0050896,GO:0051186,GO:0051188,GO:0051716,GO:0071496,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617,GO:1902494,GO:1903600	4.3.3.6	ko:K08681	ko00750,map00750	-	R07456	RC00010,RC01783,RC03043	ko00000,ko00001,ko01000	-	-	-	SNO
HKD2_k127_5556283_5	222534.KB893714_gene1630	1.078e-65	231.0	COG0586@1|root,COG0586@2|Bacteria,2IP02@201174|Actinobacteria,4EVSH@85013|Frankiales	201174|Actinobacteria	S	PFAM SNARE associated Golgi protein	-	-	-	ko:K03975	-	-	-	-	ko00000	-	-	-	SNARE_assoc
HKD2_k127_5556283_3	298655.KI912266_gene3909	9.141e-89	299.0	COG0586@1|root,COG0586@2|Bacteria,2GKGR@201174|Actinobacteria,4ESK2@85013|Frankiales	201174|Actinobacteria	S	PFAM SNARE associated Golgi protein	-	-	-	ko:K03975	-	-	-	-	ko00000	-	-	-	SNARE_assoc
HKD2_k127_5556283_2	656024.FsymDg_0612	3.541e-95	321.0	COG0451@1|root,COG0451@2|Bacteria,2GMHH@201174|Actinobacteria,4EUTC@85013|Frankiales	201174|Actinobacteria	GM	PFAM NAD-dependent epimerase dehydratase	-	-	1.1.1.412	ko:K21793,ko:K22320	ko00333,ko01130,map00333,map01130	M00838	R11663,R11666	-	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
HKD2_k127_5556283_8	656024.FsymDg_0613	1.546e-34	138.0	COG1670@1|root,COG1670@2|Bacteria	2|Bacteria	J	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins	-	-	2.3.1.178	ko:K06718	ko00260,ko01100,ko01120,map00260,map01100,map01120	M00033	R06978	RC00004,RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetyltransf_1,Acetyltransf_3,Acetyltransf_7
HKD2_k127_5556283_4	1306174.JODP01000003_gene2268	5.373e-67	232.0	COG0461@1|root,COG0461@2|Bacteria,2GKUQ@201174|Actinobacteria	201174|Actinobacteria	F	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)	pyrE	-	2.4.2.10	ko:K00762	ko00240,ko01100,map00240,map01100	M00051	R01870	RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran
HKD2_k127_5556283_1	1125971.ASJB01000057_gene5237	3.192e-97	333.0	COG0644@1|root,COG0644@2|Bacteria,2GNH7@201174|Actinobacteria,4E8RQ@85010|Pseudonocardiales	201174|Actinobacteria	C	Lycopene cyclase protein	crtY	-	5.5.1.19	ko:K06443	ko00906,ko01100,ko01110,map00906,map01100,map01110	M00097	R03824,R04801,R05341,R06962,R07856	RC01004,RC01964	ko00000,ko00001,ko00002,ko01000	-	-	-	Lycopene_cycl
HKD2_k127_5556283_6	1123023.JIAI01000032_gene4146	1.502e-47	197.0	29J5I@1|root,3062Y@2|Bacteria,2I9N8@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5556283_0	1123023.JIAI01000032_gene4145	0.0	1189.0	COG3256@1|root,COG3256@2|Bacteria,2I6ZN@201174|Actinobacteria	201174|Actinobacteria	P	nitric oxide reductase	-	-	1.7.2.5	ko:K04561	ko00910,ko01120,map00910,map01120	M00529	R00294	RC02794	ko00000,ko00001,ko00002,ko01000	3.D.4.10	-	-	COX1
HKD2_k127_5556283_7	981369.JQMJ01000002_gene6	1.364e-37	149.0	COG3385@1|root,COG3385@2|Bacteria,2GJUG@201174|Actinobacteria,2NIZY@228398|Streptacidiphilus	201174|Actinobacteria	L	Transposase DDE domain group 1	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_4
HKD2_k127_5572208_2	656024.FsymDg_3326	2.482e-60	216.0	COG0703@1|root,COG0703@2|Bacteria,2GRFW@201174|Actinobacteria,4ESVA@85013|Frankiales	201174|Actinobacteria	F	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate	aroK	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004765,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0019438,GO:0019632,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0046872,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615	2.7.1.71	ko:K00891	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	SKI
HKD2_k127_5572208_0	656024.FsymDg_3325	1.462e-147	488.0	COG0337@1|root,COG0337@2|Bacteria,2GIUZ@201174|Actinobacteria,4ERXQ@85013|Frankiales	201174|Actinobacteria	E	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)	aroB	GO:0003674,GO:0003824,GO:0003856,GO:0005488,GO:0005507,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0016020,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0030312,GO:0040007,GO:0043167,GO:0043169,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0046872,GO:0046914,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.1.71,4.2.3.4	ko:K01735,ko:K13829	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412,R03083	RC00002,RC00078,RC00847	ko00000,ko00001,ko00002,ko01000	-	-	-	DHQ_synthase,SKI
HKD2_k127_5572208_3	1463885.KL578476_gene6661	1.248e-53	214.0	COG0337@1|root,COG0757@1|root,COG0337@2|Bacteria,COG0757@2|Bacteria,2GIUZ@201174|Actinobacteria	201174|Actinobacteria	E	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)	aroB	GO:0003674,GO:0003824,GO:0003856,GO:0005488,GO:0005507,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0016020,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0030312,GO:0040007,GO:0043167,GO:0043169,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0046872,GO:0046914,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.1.71,4.2.3.4	ko:K01735,ko:K13829	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412,R03083	RC00002,RC00078,RC00847	ko00000,ko00001,ko00002,ko01000	-	-	-	DHQ_synthase,SKI
HKD2_k127_5572208_4	222534.KB893712_gene4831	2.634e-31	127.0	COG2402@1|root,COG2402@2|Bacteria,2IRQ5@201174|Actinobacteria,4EW8F@85013|Frankiales	201174|Actinobacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
HKD2_k127_5572208_1	298655.KI912267_gene7558	1.046e-88	296.0	COG0231@1|root,COG0231@2|Bacteria,2GJMS@201174|Actinobacteria,4ERK9@85013|Frankiales	201174|Actinobacteria	J	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase	efp	GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K02356	-	-	-	-	ko00000,ko03012	-	-	-	EFP,EFP_N,Elong-fact-P_C
HKD2_k127_5585970_0	479432.Sros_4836	1.519e-275	862.0	COG0465@1|root,COG0465@2|Bacteria,2GJ4Q@201174|Actinobacteria,4EGHW@85012|Streptosporangiales	201174|Actinobacteria	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
HKD2_k127_5585970_1	526225.Gobs_3392	1.358e-69	247.0	COG0300@1|root,COG0300@2|Bacteria	2|Bacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	1.1.1.102	ko:K04708	ko00600,ko01100,map00600,map01100	M00094,M00099	R02978	RC00089	ko00000,ko00001,ko00002,ko01000	-	-	-	adh_short
HKD2_k127_5585970_2	656024.FsymDg_1780	2.169e-25	108.0	2EGIC@1|root,33AAH@2|Bacteria,2GTD1@201174|Actinobacteria,4ETIH@85013|Frankiales	201174|Actinobacteria	S	Protein of unknown function (DUF3099)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3099
HKD2_k127_5647383_14	106370.Francci3_3838	3.902e-26	110.0	2DR5U@1|root,33AAR@2|Bacteria,2GX63@201174|Actinobacteria,4EXBY@85013|Frankiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5647383_11	208444.JNYY01000005_gene6171	9.072e-43	166.0	COG3427@1|root,COG3427@2|Bacteria,2II8Y@201174|Actinobacteria,4E5GT@85010|Pseudonocardiales	201174|Actinobacteria	S	PFAM Polyketide cyclase dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
HKD2_k127_5647383_15	680198.SCAB_31171	2.754e-23	103.0	2E39N@1|root,32Y97@2|Bacteria,2GQFF@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF3117)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3117
HKD2_k127_5647383_6	298655.KI912266_gene1960	1.812e-89	299.0	COG4122@1|root,COG4122@2|Bacteria,2GPEV@201174|Actinobacteria,4ESNB@85013|Frankiales	201174|Actinobacteria	S	PFAM O-methyltransferase, family 3	-	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Methyltransf_24,Methyltransf_3
HKD2_k127_5647383_5	298653.Franean1_0884	4.074e-97	335.0	COG1595@1|root,COG1595@2|Bacteria,2GK4C@201174|Actinobacteria,4ESES@85013|Frankiales	201174|Actinobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	sigE	GO:0000302,GO:0000988,GO:0000990,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0009266,GO:0009405,GO:0009408,GO:0009410,GO:0009605,GO:0009607,GO:0009628,GO:0009636,GO:0009889,GO:0010035,GO:0010468,GO:0010556,GO:0016987,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0040007,GO:0042221,GO:0042493,GO:0042542,GO:0043207,GO:0043254,GO:0044087,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0046677,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0060255,GO:0065007,GO:0075136,GO:0080090,GO:0090034,GO:0097159,GO:0140110,GO:1901363,GO:1901700,GO:1903506,GO:2000112,GO:2000142,GO:2001141	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD2_k127_5647383_16	479432.Sros_8415	1.524e-14	86.0	COG5662@1|root,COG5662@2|Bacteria,2GKPI@201174|Actinobacteria,4EJRI@85012|Streptosporangiales	201174|Actinobacteria	K	Putative zinc-finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
HKD2_k127_5647383_9	1120950.KB892823_gene489	5.802e-49	189.0	COG3026@1|root,COG3026@2|Bacteria,2IRR9@201174|Actinobacteria,4DSGE@85009|Propionibacteriales	201174|Actinobacteria	T	antisigma factor binding	-	-	-	ko:K03598	-	-	-	-	ko00000,ko03021	-	-	-	MucB_RseB
HKD2_k127_5647383_3	222534.KB893670_gene3718	1.368e-117	394.0	COG0265@1|root,COG0265@2|Bacteria,2GJ96@201174|Actinobacteria	201174|Actinobacteria	O	Peptidase s1 and s6 chymotrypsin hap	-	-	-	ko:K08372	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ_2,Trypsin_2
HKD2_k127_5647383_13	222534.KB893670_gene3717	1.11e-31	138.0	COG1826@1|root,COG1826@2|Bacteria,2IR0U@201174|Actinobacteria,4ETJD@85013|Frankiales	201174|Actinobacteria	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation	tatB	GO:0008150,GO:0040007	-	ko:K03117	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
HKD2_k127_5647383_0	106370.Francci3_2206	2.709e-221	698.0	COG3266@1|root,COG3266@2|Bacteria,2I302@201174|Actinobacteria,4EUA2@85013|Frankiales	201174|Actinobacteria	S	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5647383_2	463191.SSEG_04250	8.391e-164	528.0	COG0489@1|root,COG0489@2|Bacteria,2GJUZ@201174|Actinobacteria	201174|Actinobacteria	D	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP	mrp	-	-	ko:K03593	-	-	-	-	ko00000,ko03029,ko03036	-	-	-	FeS_assembly_P,ParA
HKD2_k127_5647383_8	710111.FraQA3DRAFT_5538	8.675e-57	207.0	COG1846@1|root,COG1846@2|Bacteria,2IJHQ@201174|Actinobacteria,4ET44@85013|Frankiales	201174|Actinobacteria	K	PFAM regulatory protein, MarR	-	-	-	-	-	-	-	-	-	-	-	-	MarR_2
HKD2_k127_5647383_7	710111.FraQA3DRAFT_5553	3.181e-61	217.0	COG4420@1|root,COG4420@2|Bacteria,2GJRV@201174|Actinobacteria,4ESVH@85013|Frankiales	201174|Actinobacteria	S	Protein of unknown function (DUF1003)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1003
HKD2_k127_5647383_1	106370.Francci3_3817	1.786e-204	643.0	COG1873@1|root,COG2239@1|root,COG1873@2|Bacteria,COG2239@2|Bacteria,2GMMK@201174|Actinobacteria,4ERJN@85013|Frankiales	201174|Actinobacteria	P	CBS domain	mgtE	-	-	-	-	-	-	-	-	-	-	-	CBS,MgtE_N,PRC
HKD2_k127_5647383_4	557599.MKAN_26895	4.009e-100	346.0	COG1028@1|root,COG1028@2|Bacteria,2GJU1@201174|Actinobacteria,236CE@1762|Mycobacteriaceae	201174|Actinobacteria	IQ	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	-	-	1.1.1.69	ko:K00046	-	-	-	-	ko00000,ko01000	-	-	-	adh_short_C2
HKD2_k127_5647383_18	1206743.BAGM01000028_gene2863	1.263e-06	61.0	COG1487@1|root,COG1487@2|Bacteria,2GPT6@201174|Actinobacteria,4G9CZ@85025|Nocardiaceae	201174|Actinobacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
HKD2_k127_5647383_10	1157634.KB912944_gene3849	6.438e-48	180.0	2E6WZ@1|root,331GF@2|Bacteria,2IFC6@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5647383_17	1268622.AVS7_01804	5.349e-07	58.0	COG2050@1|root,COG2050@2|Bacteria,1RK46@1224|Proteobacteria,2VPWT@28216|Betaproteobacteria,4ADDQ@80864|Comamonadaceae	28216|Betaproteobacteria	Q	Thioesterase superfamily protein	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
HKD2_k127_5651054_0	298653.Franean1_5166	7.808e-138	447.0	COG0296@1|root,COG0296@2|Bacteria,2GMIS@201174|Actinobacteria,4ES7Q@85013|Frankiales	201174|Actinobacteria	G	TIGRFAM malto-oligosyltrehalose trehalohydrolase	treZ	-	3.2.1.141	ko:K01236	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11256	RC00049	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48,DUF3459
HKD2_k127_5651054_3	1380387.JADM01000011_gene3517	2.28e-05	50.0	COG1476@1|root,COG1476@2|Bacteria,1MYZQ@1224|Proteobacteria,1S6SX@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	Helix-turn-helix	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
HKD2_k127_567279_11	1449976.KALB_4142	4.499e-24	104.0	COG0636@1|root,COG0636@2|Bacteria,2IS0Q@201174|Actinobacteria,4E61A@85010|Pseudonocardiales	201174|Actinobacteria	C	ATP synthase subunit C	-	-	-	ko:K02124	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_C
HKD2_k127_567279_18	1449976.KALB_4143	1.189e-10	66.0	COG1436@1|root,COG1436@2|Bacteria,2I80G@201174|Actinobacteria	201174|Actinobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_567279_17	284031.JNXD01000003_gene3713	1.008e-11	75.0	COG1390@1|root,COG1390@2|Bacteria,2GT2F@201174|Actinobacteria	201174|Actinobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	-	-	-	-	-	-	-	-	-	-	-	-	vATP-synt_E
HKD2_k127_567279_0	55952.BU52_25980	6.852e-218	698.0	COG1155@1|root,COG1155@2|Bacteria,2HESQ@201174|Actinobacteria	201174|Actinobacteria	C	ATPsynthase alpha/beta subunit N-term extension	-	-	3.6.3.14,3.6.3.15	ko:K02117	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002,ko01000	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn
HKD2_k127_567279_1	55952.BU52_25975	1.61e-203	643.0	COG1156@1|root,COG1156@2|Bacteria,2GKPJ@201174|Actinobacteria	201174|Actinobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit	-	-	-	ko:K02118	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N
HKD2_k127_567279_13	2002.JOEQ01000021_gene6802	5.217e-20	106.0	COG1394@1|root,COG1394@2|Bacteria,2INZB@201174|Actinobacteria	201174|Actinobacteria	C	ATP synthase subunit D	-	-	-	ko:K02120	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_D
HKD2_k127_567279_20	1206739.BAGJ01000135_gene675	8.395e-05	53.0	COG0748@1|root,COG0748@2|Bacteria,2IIRT@201174|Actinobacteria,4G1BG@85025|Nocardiaceae	201174|Actinobacteria	P	F420H(2)-dependent quinone reductase	-	-	-	-	-	-	-	-	-	-	-	-	F420H2_quin_red
HKD2_k127_567279_16	526225.Gobs_2588	8.206e-13	70.0	COG1309@1|root,COG1309@2|Bacteria,2GPBQ@201174|Actinobacteria,4EWTC@85013|Frankiales	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
HKD2_k127_567279_21	98439.AJLL01000091_gene194	0.0001992	50.0	COG1028@1|root,COG1028@2|Bacteria,1G67A@1117|Cyanobacteria,1JM30@1189|Stigonemataceae	1117|Cyanobacteria	IQ	Fungal family of unknown function (DUF1776)	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HKD2_k127_567279_6	1123322.KB904664_gene4034	4.181e-58	212.0	COG1028@1|root,COG1028@2|Bacteria,2I32I@201174|Actinobacteria	201174|Actinobacteria	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HKD2_k127_567279_5	953739.SVEN_0549	6.125e-63	222.0	COG2764@1|root,COG2764@2|Bacteria,2IG41@201174|Actinobacteria	201174|Actinobacteria	S	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	ko:K04750	-	-	-	-	ko00000	-	-	-	Glyoxalase
HKD2_k127_567279_4	345341.KUTG_08040	3.457e-70	261.0	COG2197@1|root,COG2197@2|Bacteria,2GJ46@201174|Actinobacteria,4DYGU@85010|Pseudonocardiales	201174|Actinobacteria	K	PFAM Response regulator receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HKD2_k127_567279_3	1380393.JHVP01000007_gene4387	1.153e-100	341.0	COG4585@1|root,COG4585@2|Bacteria,2GKV2@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
HKD2_k127_567279_2	1380393.JHVP01000007_gene4388	2.806e-166	542.0	COG2409@1|root,COG2409@2|Bacteria,2GJ5A@201174|Actinobacteria,4EUE1@85013|Frankiales	201174|Actinobacteria	S	MMPL family	-	-	-	ko:K06994	-	-	-	-	ko00000	-	-	-	CarboxypepD_reg,MMPL
HKD2_k127_567279_9	1380393.JHVP01000007_gene4388	5.529e-36	139.0	COG2409@1|root,COG2409@2|Bacteria,2GJ5A@201174|Actinobacteria,4EUE1@85013|Frankiales	201174|Actinobacteria	S	MMPL family	-	-	-	ko:K06994	-	-	-	-	ko00000	-	-	-	CarboxypepD_reg,MMPL
HKD2_k127_567279_10	1245475.ANAE01000210_gene1505	1.975e-26	128.0	2BVH7@1|root,32QVU@2|Bacteria,2IN4G@201174|Actinobacteria,4EQ6W@85012|Streptosporangiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_567279_12	192952.MM_0189	6.339e-24	106.0	COG4274@1|root,arCOG01119@2157|Archaea	2157|Archaea	S	pfam gyd	-	-	-	-	-	-	-	-	-	-	-	-	GYD
HKD2_k127_567279_8	1171373.PACID_29960	3.858e-39	156.0	2DKWW@1|root,30NAT@2|Bacteria	2|Bacteria	S	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_4,HTH_Tnp_4
HKD2_k127_567279_14	526225.Gobs_3532	5.881e-18	83.0	COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,2GJQI@201174|Actinobacteria,4ERUS@85013|Frankiales	201174|Actinobacteria	L	manually curated	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_28,HTH_29,HTH_32
HKD2_k127_567641_2	105422.BBPM01000046_gene1564	2.209e-08	60.0	COG0543@1|root,COG0543@2|Bacteria,2HQ24@201174|Actinobacteria,2NGGV@228398|Streptacidiphilus	201174|Actinobacteria	CH	Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B	pyrK	-	-	ko:K02823	ko00240,ko01100,map00240,map01100	-	-	-	ko00000,ko00001	-	-	-	DHODB_Fe-S_bind,FAD_binding_6,NAD_binding_1
HKD2_k127_567641_0	365528.KB891218_gene1511	0.0	1804.0	COG0458@1|root,COG0458@2|Bacteria,2GK5N@201174|Actinobacteria,4ERGS@85013|Frankiales	201174|Actinobacteria	F	Belongs to the CarB family	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
HKD2_k127_567641_1	656024.FsymDg_3316	2.053e-186	592.0	COG0505@1|root,COG0505@2|Bacteria,2GKFA@201174|Actinobacteria,4ERR1@85013|Frankiales	201174|Actinobacteria	F	Belongs to the CarA family	carA	-	6.3.5.5	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_sm_chain,GATase
HKD2_k127_5680766_2	1304865.JAGF01000001_gene96	1.451e-48	182.0	COG1020@1|root,COG1020@2|Bacteria,2HEFF@201174|Actinobacteria	201174|Actinobacteria	Q	Belongs to the long-chain O-acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	DUF1298,PAP2_3,WES_acyltransf
HKD2_k127_5680766_1	101510.RHA1_ro02079	1.133e-79	272.0	COG1335@1|root,COG1335@2|Bacteria,2IGNC@201174|Actinobacteria,4FUPI@85025|Nocardiaceae	201174|Actinobacteria	Q	Isochorismatase family	-	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
HKD2_k127_5680766_3	42256.RradSPS_0118	6.916e-25	108.0	COG0471@1|root,COG0471@2|Bacteria,2GVHZ@201174|Actinobacteria,4CRW1@84995|Rubrobacteria	84995|Rubrobacteria	P	Sodium:sulfate symporter transmembrane region	-	-	-	ko:K14445	-	-	-	-	ko00000,ko02000	2.A.47.1	-	-	Na_sulph_symp
HKD2_k127_5680766_0	1122939.ATUD01000014_gene1055	1.16e-120	399.0	COG0471@1|root,COG0471@2|Bacteria,2GVHZ@201174|Actinobacteria,4CRW1@84995|Rubrobacteria	84995|Rubrobacteria	P	Sodium:sulfate symporter transmembrane region	-	-	-	ko:K14445	-	-	-	-	ko00000,ko02000	2.A.47.1	-	-	Na_sulph_symp
HKD2_k127_5681418_11	106370.Francci3_2058	5.682e-06	48.0	COG5433@1|root,COG5433@2|Bacteria,2HYBN@201174|Actinobacteria,4EWGM@85013|Frankiales	201174|Actinobacteria	L	required for the transposition of insertion element IS2404	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_assoc
HKD2_k127_5681418_4	285535.JOEY01000096_gene3193	1.031e-59	220.0	COG2976@1|root,COG2976@2|Bacteria,2GNIS@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF4012)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4012
HKD2_k127_5681418_8	1160718.SU9_33438	6.503e-37	155.0	2DHBJ@1|root,32U91@2|Bacteria,2GPPB@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5681418_7	390989.JOEG01000006_gene876	2.223e-43	170.0	COG4585@1|root,COG4585@2|Bacteria,2GNBG@201174|Actinobacteria,4DBDK@85008|Micromonosporales	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HisKA_3
HKD2_k127_5681418_5	1463920.JOGB01000003_gene2605	2.562e-56	204.0	COG4585@1|root,COG4585@2|Bacteria,2GNBG@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HisKA_3
HKD2_k127_5681418_1	479432.Sros_4219	2.325e-85	293.0	COG2197@1|root,COG2197@2|Bacteria,2GN80@201174|Actinobacteria,4EHTP@85012|Streptosporangiales	201174|Actinobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HKD2_k127_5681418_6	1123023.JIAI01000007_gene1998	1.474e-48	177.0	COG3742@1|root,COG3742@2|Bacteria,2IS39@201174|Actinobacteria	201174|Actinobacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	ko:K19686	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PIN
HKD2_k127_5681418_10	1123023.JIAI01000007_gene1997	9.225e-26	109.0	COG4423@1|root,COG4423@2|Bacteria,2GU7X@201174|Actinobacteria	201174|Actinobacteria	S	Rv0623-like transcription factor	vapB28	GO:0008150,GO:0040008,GO:0045927,GO:0048518,GO:0050789,GO:0065007	-	ko:K19687	-	-	-	-	ko00000,ko02048	-	-	-	PSK_trans_fac
HKD2_k127_5681418_3	547163.BN979_00009	3.397e-74	253.0	COG0454@1|root,COG0456@2|Bacteria,2GNNG@201174|Actinobacteria,234WB@1762|Mycobacteriaceae	201174|Actinobacteria	K	Acetyltransferase (GNAT) domain	yjgM	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,MarR_2
HKD2_k127_5681418_9	67373.JOBF01000004_gene858	1.332e-36	157.0	COG1018@1|root,COG1018@2|Bacteria,2IN34@201174|Actinobacteria	201174|Actinobacteria	C	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5681418_0	1449346.JQMO01000003_gene3067	4.61e-215	705.0	COG3127@1|root,COG3127@2|Bacteria,2H37M@201174|Actinobacteria	201174|Actinobacteria	Q	ABC transporter (Permease)	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HKD2_k127_5681418_2	1449353.JQMQ01000005_gene3885	4.736e-85	285.0	COG1136@1|root,COG1136@2|Bacteria,2GJN6@201174|Actinobacteria,2NEDZ@228398|Streptacidiphilus	201174|Actinobacteria	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD2_k127_5718616_11	1068980.ARVW01000001_gene2371	2.953e-27	123.0	COG5563@1|root,COG5563@2|Bacteria,2GTNJ@201174|Actinobacteria,4EDEJ@85010|Pseudonocardiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5718616_1	1386089.N865_16800	3.906e-177	573.0	COG0438@1|root,COG0438@2|Bacteria,2ICGI@201174|Actinobacteria	201174|Actinobacteria	M	Glycosyl transferases group 1	-	-	2.4.1.245	ko:K13057	ko00500,ko01100,map00500,map01100	-	R08946,R10525,R11306	RC00005,RC00049,RC02748	ko00000,ko00001,ko01000	-	GT4	-	Glycos_transf_1,YHS
HKD2_k127_5718616_12	106370.Francci3_1559	4.477e-09	68.0	2EH65@1|root,3351X@2|Bacteria,2HUNA@201174|Actinobacteria,4EWVN@85013|Frankiales	201174|Actinobacteria	S	Domain of unknown function (DUF1876)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1876
HKD2_k127_5718616_7	298654.FraEuI1c_6692	1.183e-80	274.0	COG3467@1|root,COG3467@2|Bacteria,2GJ76@201174|Actinobacteria,4ESS3@85013|Frankiales	201174|Actinobacteria	S	Pyridoxamine 5'-phosphate oxidase	-	-	-	ko:K07005	-	-	-	-	ko00000	-	-	-	Acetyltransf_3,Pyridox_ox_2
HKD2_k127_5718616_3	1370120.AUWR01000027_gene2509	2.008e-132	435.0	COG1167@1|root,COG1167@2|Bacteria,2GM6I@201174|Actinobacteria,2341H@1762|Mycobacteriaceae	201174|Actinobacteria	K	Aminotransferase class I and II	ptsJ	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2,GntR
HKD2_k127_5718616_5	685727.REQ_12370	9.971e-101	357.0	COG3301@1|root,COG3301@2|Bacteria,2GJ4S@201174|Actinobacteria,4FWQS@85025|Nocardiaceae	201174|Actinobacteria	P	Polysulphide reductase, NrfD	nrfD	-	-	-	-	-	-	-	-	-	-	-	NrfD
HKD2_k127_5718616_2	644283.Micau_3238	7.292e-154	492.0	COG0437@1|root,COG0437@2|Bacteria,2I2DV@201174|Actinobacteria,4DCET@85008|Micromonosporales	201174|Actinobacteria	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	hybA	-	-	ko:K00124	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001	-	-	-	Fer4_11,Fer4_3,Fer4_4,Fer4_7
HKD2_k127_5718616_0	882086.SacxiDRAFT_0135	0.0	1367.0	COG0243@1|root,COG3383@1|root,COG0243@2|Bacteria,COG3383@2|Bacteria,2GJCK@201174|Actinobacteria,4DZEM@85010|Pseudonocardiales	201174|Actinobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
HKD2_k127_5718616_6	367299.JOEE01000008_gene464	5.553e-89	302.0	COG0243@1|root,COG0243@2|Bacteria,2GJ7X@201174|Actinobacteria,4FEE4@85021|Intrasporangiaceae	201174|Actinobacteria	C	Molybdopterin oxidoreductase Fe4S4 domain	fdhA	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Molybdop_Fe4S4
HKD2_k127_5718616_4	1236902.ANAS01000001_gene1925	2.296e-112	374.0	COG1526@1|root,COG1526@2|Bacteria,2GKWC@201174|Actinobacteria,4EFG2@85012|Streptosporangiales	201174|Actinobacteria	C	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH	fdhD	-	-	ko:K02379	-	-	-	-	ko00000	-	-	-	FdhD-NarQ
HKD2_k127_5718616_9	656024.FsymDg_0691	2.24e-49	188.0	COG3409@1|root,COG3409@2|Bacteria,2IRFZ@201174|Actinobacteria	201174|Actinobacteria	M	Putative peptidoglycan binding domain	pdcA	-	-	-	-	-	-	-	-	-	-	-	PG_binding_1
HKD2_k127_5718616_8	1146883.BLASA_5012	2.246e-79	285.0	COG1403@1|root,COG1403@2|Bacteria,2GU7G@201174|Actinobacteria,4EV73@85013|Frankiales	201174|Actinobacteria	L	HNH endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DUF222,HNH
HKD2_k127_5718616_10	1313172.YM304_39110	4.385e-28	130.0	COG1487@1|root,COG1487@2|Bacteria,2IGMY@201174|Actinobacteria	201174|Actinobacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	vapC	-	-	-	-	-	-	-	-	-	-	-	PIN
HKD2_k127_5723084_10	105420.BBPO01000014_gene6063	2.039e-05	56.0	COG1366@1|root,COG1366@2|Bacteria,2GT1D@201174|Actinobacteria,2NJ4J@228398|Streptacidiphilus	201174|Actinobacteria	T	STAS domain	-	-	-	-	-	-	-	-	-	-	-	-	STAS_2
HKD2_k127_5723084_2	1246448.ANAZ01000023_gene2092	2.555e-114	383.0	COG3263@1|root,COG3263@2|Bacteria,2GJ9B@201174|Actinobacteria,4EFZQ@85012|Streptosporangiales	201174|Actinobacteria	P	TrkA-C domain	-	-	-	ko:K11105	-	-	-	-	ko00000,ko02000	2.A.36.6	-	-	Na_H_Exchanger,TrkA_C
HKD2_k127_5723084_9	1122611.KB903939_gene534	2.552e-10	69.0	COG0490@1|root,COG0490@2|Bacteria,2IFBQ@201174|Actinobacteria,4EJDK@85012|Streptosporangiales	201174|Actinobacteria	P	TrkA-C domain	-	-	-	ko:K07228	-	-	-	-	ko00000	-	-	-	TrkA_C
HKD2_k127_5723084_6	1133850.SHJG_2469	1.989e-53	193.0	COG3387@1|root,COG3387@2|Bacteria,2I95N@201174|Actinobacteria	201174|Actinobacteria	G	Glycosyl hydrolases family 15	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_15
HKD2_k127_5723084_1	1255043.TVNIR_1112	6.869e-193	617.0	COG3387@1|root,COG3387@2|Bacteria,1MV08@1224|Proteobacteria,1RS4U@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Glucoamylase and related glycosyl hydrolases	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_15
HKD2_k127_5723084_7	42256.RradSPS_0959	1.4e-46	180.0	COG0364@1|root,COG0364@2|Bacteria,2GISI@201174|Actinobacteria,4CPHW@84995|Rubrobacteria	201174|Actinobacteria	G	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone	-	-	1.1.1.363,1.1.1.49	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	M00004,M00006,M00008	R00835,R02736,R10907	RC00001,RC00066	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	G6PD_C,G6PD_N
HKD2_k127_5723084_5	42256.RradSPS_0959	1.002e-84	295.0	COG0364@1|root,COG0364@2|Bacteria,2GISI@201174|Actinobacteria,4CPHW@84995|Rubrobacteria	201174|Actinobacteria	G	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone	-	-	1.1.1.363,1.1.1.49	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	M00004,M00006,M00008	R00835,R02736,R10907	RC00001,RC00066	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	G6PD_C,G6PD_N
HKD2_k127_5723084_4	103733.JNYO01000025_gene8911	4.05e-90	314.0	COG3835@1|root,COG3835@2|Bacteria,2GRBZ@201174|Actinobacteria,4E2N5@85010|Pseudonocardiales	201174|Actinobacteria	KT	PucR C-terminal helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_30
HKD2_k127_5723084_0	526225.Gobs_2928	2.002e-257	822.0	COG1009@1|root,COG2111@1|root,COG1009@2|Bacteria,COG2111@2|Bacteria,2GIT4@201174|Actinobacteria,4ERUP@85013|Frankiales	201174|Actinobacteria	CP	Na H antiporter	mnhB	-	-	ko:K05565,ko:K14086	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	DUF4040,MnhB,NADHdh,Proton_antipo_M,Proton_antipo_N
HKD2_k127_5723084_8	526225.Gobs_2929	8.682e-26	116.0	COG1006@1|root,COG1006@2|Bacteria,2IR2B@201174|Actinobacteria	201174|Actinobacteria	P	Multisubunit Na H antiporter MnhC subunit	mnhC	-	-	ko:K05567	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Oxidored_q2
HKD2_k127_5723084_3	1906.SFRA_30525	7.863e-98	343.0	COG0651@1|root,COG0651@2|Bacteria,2HAC7@201174|Actinobacteria	201174|Actinobacteria	CP	Formate hydrogenlyase subunit 3 Multisubunit Na H antiporter, MnhD subunit	mnhD	-	-	ko:K05568	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Proton_antipo_M
HKD2_k127_5743314_4	477641.MODMU_3038	1.577e-70	256.0	COG0726@1|root,COG0726@2|Bacteria	2|Bacteria	G	polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
HKD2_k127_5743314_7	266940.Krad_4252	2.345e-17	85.0	2E3KN@1|root,32YIY@2|Bacteria,2GQXH@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF2630)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2630
HKD2_k127_5743314_0	443255.SCLAV_p1508	6.573e-261	824.0	COG2192@1|root,COG2192@2|Bacteria,2GJHV@201174|Actinobacteria	201174|Actinobacteria	O	Carbamoyltransferase	-	-	-	ko:K00612	-	-	-	-	ko00000,ko01000	-	-	-	Carbam_trans_C,Carbam_trans_N
HKD2_k127_5743314_3	443255.SCLAV_p1509	3.115e-128	418.0	COG2175@1|root,COG2175@2|Bacteria,2GSEY@201174|Actinobacteria	201174|Actinobacteria	Q	clavaminate synthase activity	-	-	-	-	-	-	-	-	-	-	-	-	TauD
HKD2_k127_5743314_1	1173028.ANKO01000056_gene2184	2.841e-141	467.0	COG0665@1|root,COG0665@2|Bacteria,1GCJX@1117|Cyanobacteria	1117|Cyanobacteria	E	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_3,DAO
HKD2_k127_5743314_2	710111.FraQA3DRAFT_4730	1.603e-134	434.0	COG1801@1|root,COG1801@2|Bacteria	2|Bacteria	L	Protein of unknown function DUF72	yunF	-	-	-	-	-	-	-	-	-	-	-	DUF72
HKD2_k127_5743314_5	1122939.ATUD01000003_gene3310	1.262e-27	116.0	COG0477@1|root,COG0477@2|Bacteria,2HF4N@201174|Actinobacteria,4CPRZ@84995|Rubrobacteria	84995|Rubrobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD2_k127_5763558_2	298653.Franean1_0337	1.746e-58	207.0	COG0744@1|root,COG2815@1|root,COG0744@2|Bacteria,COG2815@2|Bacteria,2GK21@201174|Actinobacteria,4ERGQ@85013|Frankiales	201174|Actinobacteria	M	PFAM glycosyl transferase, family 51	pon1	-	-	-	-	-	-	-	-	-	-	-	PASTA,Transgly,Transpeptidase
HKD2_k127_5763558_0	656024.FsymDg_4324	6.233e-132	445.0	COG0744@1|root,COG2815@1|root,COG0744@2|Bacteria,COG2815@2|Bacteria,2GK21@201174|Actinobacteria,4ERGQ@85013|Frankiales	201174|Actinobacteria	M	PFAM glycosyl transferase, family 51	pon1	-	-	-	-	-	-	-	-	-	-	-	PASTA,Transgly,Transpeptidase
HKD2_k127_5763558_3	298654.FraEuI1c_0347	9.762e-48	175.0	COG1610@1|root,COG1610@2|Bacteria,2IFFJ@201174|Actinobacteria,4ET0X@85013|Frankiales	201174|Actinobacteria	S	Yqey-like protein	yqeY	-	-	ko:K09117	-	-	-	-	ko00000	-	-	-	YqeY
HKD2_k127_5763558_1	656024.FsymDg_4326	9.244e-121	406.0	COG1408@1|root,COG1408@2|Bacteria,2GJHT@201174|Actinobacteria,4ES1S@85013|Frankiales	201174|Actinobacteria	S	PFAM metallophosphoesterase	ykuE	-	-	ko:K07098	-	-	-	-	ko00000	-	-	-	Metallophos,Metallophos_2
HKD2_k127_5763558_5	436229.JOEH01000009_gene4564	3.198e-07	57.0	COG1609@1|root,COG1609@2|Bacteria,2GSWK@201174|Actinobacteria,2NJKA@228398|Streptacidiphilus	201174|Actinobacteria	K	Phage integrase, N-terminal SAM-like domain	-	-	-	-	-	-	-	-	-	-	-	-	LacI,Phage_int_SAM_3,Phage_integrase
HKD2_k127_5763558_4	1133850.SHJG_2356	1.271e-07	61.0	2E5RJ@1|root,329X9@2|Bacteria,2IN97@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF4232)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4232
HKD2_k127_5763558_6	1229205.BUPH_08527	2.976e-05	46.0	COG5659@1|root,COG5659@2|Bacteria,1MWAV@1224|Proteobacteria,2W56T@28216|Betaproteobacteria,1KIBA@119060|Burkholderiaceae	28216|Betaproteobacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5
HKD2_k127_5767378_18	1246445.ANAY01000085_gene3920	3.523e-09	57.0	2BWAE@1|root,33Q9G@2|Bacteria,2GMIH@201174|Actinobacteria,4EM3H@85012|Streptosporangiales	201174|Actinobacteria	S	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_4,HTH_Tnp_4
HKD2_k127_5767378_20	68194.JNXR01000015_gene8119	0.0002285	50.0	COG1752@1|root,COG1752@2|Bacteria,2IB0F@201174|Actinobacteria	201174|Actinobacteria	S	esterase of the alpha-beta hydrolase superfamily	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
HKD2_k127_5767378_9	1449976.KALB_4451	3.073e-82	286.0	COG2175@1|root,COG2175@2|Bacteria,2IP3Y@201174|Actinobacteria,4E7ZJ@85010|Pseudonocardiales	201174|Actinobacteria	Q	Taurine catabolism dioxygenase TauD, TfdA family	-	-	-	-	-	-	-	-	-	-	-	-	TauD
HKD2_k127_5767378_1	1449976.KALB_4450	5.023e-168	546.0	28M6N@1|root,2ZAK9@2|Bacteria,2GMXJ@201174|Actinobacteria,4EECD@85010|Pseudonocardiales	201174|Actinobacteria	S	P-aminobenzoate N-oxygenase AurF	-	-	-	-	-	-	-	-	-	-	-	-	AurF
HKD2_k127_5767378_0	1449976.KALB_4449	2.95e-196	637.0	COG1509@1|root,COG1509@2|Bacteria,2GM2P@201174|Actinobacteria,4E03I@85010|Pseudonocardiales	201174|Actinobacteria	E	lysine 2,3-aminomutase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5767378_3	1449976.KALB_4448	7.207e-135	457.0	COG4948@1|root,COG4948@2|Bacteria,2GJJR@201174|Actinobacteria,4E19V@85010|Pseudonocardiales	201174|Actinobacteria	M	Mandelate racemase / muconate lactonizing enzyme, C-terminal domain	-	-	5.1.1.20	ko:K19802	-	-	R10938	RC03309	ko00000,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
HKD2_k127_5767378_6	1449976.KALB_4447	4.748e-125	409.0	COG2055@1|root,COG2055@2|Bacteria,2GN93@201174|Actinobacteria,4E5WZ@85010|Pseudonocardiales	201174|Actinobacteria	C	Malate/L-lactate dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Ldh_2
HKD2_k127_5767378_5	1449976.KALB_4446	1.397e-129	445.0	COG0026@1|root,COG0026@2|Bacteria,2I481@201174|Actinobacteria,4EE4X@85010|Pseudonocardiales	201174|Actinobacteria	F	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp
HKD2_k127_5767378_8	1449976.KALB_4445	1.988e-116	388.0	COG3146@1|root,COG3146@2|Bacteria,2IK34@201174|Actinobacteria,4E6VJ@85010|Pseudonocardiales	201174|Actinobacteria	S	Acetyltransferase (GNAT) domain	-	-	-	ko:K09919	-	-	-	-	ko00000	-	-	-	Acetyltransf_6,FemAB_like
HKD2_k127_5767378_4	1449976.KALB_4444	2.583e-133	449.0	COG0115@1|root,COG0115@2|Bacteria,2GKJ1@201174|Actinobacteria,4E5ED@85010|Pseudonocardiales	201174|Actinobacteria	EH	Amino-transferase class IV	ilvE	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
HKD2_k127_5767378_19	101510.RHA1_ro02969	1.084e-07	63.0	2B6I0@1|root,31ZGA@2|Bacteria,2HJ9Z@201174|Actinobacteria,4G61A@85025|Nocardiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5767378_7	1449976.KALB_4443	1.273e-117	398.0	COG0477@1|root,COG0477@2|Bacteria,2I2ZS@201174|Actinobacteria,4EE07@85010|Pseudonocardiales	201174|Actinobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD2_k127_5767378_2	1449976.KALB_4442	2.058e-146	502.0	COG0151@1|root,COG0151@2|Bacteria,2GXFQ@201174|Actinobacteria,4EB0K@85010|Pseudonocardiales	201174|Actinobacteria	F	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_4
HKD2_k127_5767378_12	73044.JNXP01000001_gene4562	8.81e-59	211.0	COG0454@1|root,COG0456@2|Bacteria,2IFM6@201174|Actinobacteria	201174|Actinobacteria	K	PFAM GCN5-related N-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HKD2_k127_5767378_16	106370.Francci3_0151	3.779e-20	92.0	COG3293@1|root,COG3293@2|Bacteria,2GMT0@201174|Actinobacteria,4EV5F@85013|Frankiales	201174|Actinobacteria	L	PFAM transposase IS4 family protein	-	-	-	ko:K07492	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DDE_Tnp_1_2,DUF4096
HKD2_k127_5767378_17	1463917.JODC01000015_gene1816	3.911e-10	67.0	COG3293@1|root,COG3293@2|Bacteria,2GMT0@201174|Actinobacteria	201174|Actinobacteria	L	Transposase	-	-	-	ko:K07492	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DDE_Tnp_1_2,DUF4096
HKD2_k127_5767378_15	1463885.KL578405_gene4087	4.783e-28	114.0	COG3293@1|root,COG3293@2|Bacteria,2GMT0@201174|Actinobacteria	201174|Actinobacteria	L	Transposase	-	-	-	ko:K07492	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DDE_Tnp_1_2,DUF4096
HKD2_k127_5767378_10	710111.FraQA3DRAFT_0748	8.681e-70	242.0	COG3293@1|root,COG3293@2|Bacteria,2IHX5@201174|Actinobacteria,4EVCP@85013|Frankiales	201174|Actinobacteria	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_2,DUF4096
HKD2_k127_5767378_13	710111.FraQA3DRAFT_0747	7.948e-58	203.0	COG3293@1|root,COG3293@2|Bacteria,2IGHY@201174|Actinobacteria,4EX98@85013|Frankiales	201174|Actinobacteria	L	Putative transposase of IS4/5 family (DUF4096)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4096
HKD2_k127_5767378_14	526225.Gobs_2601	8.662e-55	194.0	COG3293@1|root,COG3293@2|Bacteria,2IIAY@201174|Actinobacteria,4EVQX@85013|Frankiales	201174|Actinobacteria	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_2,DUF4096
HKD2_k127_5767378_11	526225.Gobs_0760	3.713e-63	225.0	COG3293@1|root,COG3293@2|Bacteria,2IIAY@201174|Actinobacteria,4EVQX@85013|Frankiales	201174|Actinobacteria	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_2,DUF4096
HKD2_k127_5767378_21	1171373.PACID_03410	0.0002356	43.0	COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,2IAHV@201174|Actinobacteria,4DUEP@85009|Propionibacteriales	201174|Actinobacteria	L	Winged helix-turn helix	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_28,HTH_32,HTH_33
HKD2_k127_5898425_4	1380393.JHVP01000006_gene3854	7.45e-86	296.0	2BWAE@1|root,2ZC7D@2|Bacteria,2GMCH@201174|Actinobacteria,4ETN4@85013|Frankiales	201174|Actinobacteria	S	PFAM transposase IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_4
HKD2_k127_5898425_13	591167.Sfla_1835	6.065e-08	59.0	COG2409@1|root,COG2409@2|Bacteria,2GJ5A@201174|Actinobacteria	201174|Actinobacteria	F	Drug exporters of the RND superfamily	-	-	-	ko:K06994	-	-	-	-	ko00000	-	-	-	MMPL
HKD2_k127_5898425_11	1123320.KB889681_gene2579	1.715e-32	138.0	COG0684@1|root,COG0684@2|Bacteria	2|Bacteria	H	ribonuclease inhibitor activity	-	-	-	-	-	-	-	-	-	-	-	-	RraA-like
HKD2_k127_5898425_0	1123320.KB889681_gene2581	5.585e-251	784.0	COG0146@1|root,COG0146@2|Bacteria,2HWA8@201174|Actinobacteria	201174|Actinobacteria	EQ	PFAM Hydantoinase B oxoprolinase	-	-	3.5.2.14	ko:K01474	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydantoinase_B
HKD2_k127_5898425_2	1123320.KB889681_gene2582	1.268e-148	502.0	COG0145@1|root,COG0145@2|Bacteria,2GIYE@201174|Actinobacteria	201174|Actinobacteria	EQ	PFAM Hydantoinase oxoprolinase	-	-	3.5.2.14	ko:K01473	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydant_A_N,Hydantoinase_A
HKD2_k127_5898425_8	1460634.JCM19037_740	2.005e-45	181.0	COG0145@1|root,COG0145@2|Bacteria,1TQVB@1239|Firmicutes,4HB8X@91061|Bacilli	91061|Bacilli	EQ	COG0145 N-methylhydantoinase A acetone carboxylase, beta subunit	-	-	3.5.2.14	ko:K01473	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydant_A_N,Hydantoinase_A
HKD2_k127_5898425_9	1313172.YM304_42260	7.316e-44	174.0	COG0662@1|root,COG0662@2|Bacteria,2H8T0@201174|Actinobacteria	201174|Actinobacteria	G	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HKD2_k127_5898425_6	1313172.YM304_42290	4.569e-56	206.0	COG2186@1|root,COG2186@2|Bacteria	2|Bacteria	K	Transcriptional regulator	-	-	-	ko:K05799	-	-	-	-	ko00000,ko03000	-	-	-	FCD,GntR
HKD2_k127_5898425_14	1123320.KB889681_gene2597	7.049e-06	49.0	COG0346@1|root,COG0346@2|Bacteria,2IK75@201174|Actinobacteria	201174|Actinobacteria	E	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HKD2_k127_5898425_10	1123320.KB889681_gene2597	8.069e-36	147.0	COG0346@1|root,COG0346@2|Bacteria,2IK75@201174|Actinobacteria	201174|Actinobacteria	E	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HKD2_k127_5898425_7	1123320.KB889681_gene2591	3.06e-47	179.0	COG0346@1|root,COG0346@2|Bacteria	2|Bacteria	E	lactoylglutathione lyase activity	-	-	4.4.1.5	ko:K01759	ko00620,map00620	-	R02530	RC00004,RC00740	ko00000,ko00001,ko01000	-	-	-	Glyoxalase
HKD2_k127_5898425_3	1123320.KB889681_gene2603	2.777e-86	311.0	COG1079@1|root,COG1079@2|Bacteria,2I97H@201174|Actinobacteria	201174|Actinobacteria	S	Branched-chain amino acid transport system / permease component	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
HKD2_k127_5898425_5	1123320.KB889681_gene2602	4.35e-71	269.0	COG4603@1|root,COG4603@2|Bacteria,2IAAG@201174|Actinobacteria	201174|Actinobacteria	S	Branched-chain amino acid transport system / permease component	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
HKD2_k127_5898425_1	1123320.KB889681_gene2601	2.336e-156	509.0	COG3845@1|root,COG3845@2|Bacteria,2H7KJ@201174|Actinobacteria	201174|Actinobacteria	S	ABC transporter	-	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
HKD2_k127_5898425_12	298655.KI912267_gene7898	3.409e-18	90.0	COG1744@1|root,COG1744@2|Bacteria,2GKJZ@201174|Actinobacteria	201174|Actinobacteria	S	ABC transporter substrate-binding protein PnrA-like	-	-	-	ko:K07335	-	-	-	-	ko00000	-	-	-	Bmp
HKD2_k127_591195_5	1416759.AYMR01000009_gene3212	7.103e-18	85.0	COG4118@1|root,COG4118@2|Bacteria,2GW5I@201174|Actinobacteria	201174|Actinobacteria	D	Antitoxin Phd_YefM, type II toxin-antitoxin system	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
HKD2_k127_591195_4	469383.Cwoe_3714	1.057e-39	154.0	COG1487@1|root,COG1487@2|Bacteria,2IGMY@201174|Actinobacteria,4CT46@84995|Rubrobacteria	84995|Rubrobacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
HKD2_k127_591195_3	656024.FsymDg_2367	6.657e-107	363.0	COG0204@1|root,COG0204@2|Bacteria,2IAXZ@201174|Actinobacteria	201174|Actinobacteria	I	PFAM Phospholipid glycerol acyltransferase	-	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
HKD2_k127_591195_0	656024.FsymDg_2368	9.558e-296	912.0	COG3875@1|root,COG3875@2|Bacteria,2IAM4@201174|Actinobacteria	201174|Actinobacteria	S	Domain of unknown function (DUF2088)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2088
HKD2_k127_591195_2	298655.KI912266_gene3537	6.49e-169	556.0	COG1063@1|root,COG1063@2|Bacteria,2IBQC@201174|Actinobacteria,4EWHX@85013|Frankiales	201174|Actinobacteria	C	alcohol dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
HKD2_k127_591195_1	656024.FsymDg_2370	4.847e-285	887.0	COG0451@1|root,COG0560@1|root,COG0451@2|Bacteria,COG0560@2|Bacteria,2GJVX@201174|Actinobacteria	201174|Actinobacteria	E	HAD-superfamily subfamily IB hydrolase, TIGR01490	-	-	-	-	-	-	-	-	-	-	-	-	HAD,NAD_binding_4,Sterile
HKD2_k127_5936410_1	981369.JQMJ01000004_gene4864	4.509e-58	205.0	COG1922@1|root,COG1922@2|Bacteria,2ICDG@201174|Actinobacteria,2NEZ5@228398|Streptacidiphilus	201174|Actinobacteria	M	Glycosyl transferase WecB/TagA/CpsF family	-	-	2.4.1.187	ko:K05946	ko05111,map05111	-	-	-	ko00000,ko00001,ko01000,ko01003	-	GT26	-	Glyco_tran_WecB
HKD2_k127_5936410_2	867845.KI911784_gene1663	4.112e-26	125.0	COG1215@1|root,COG1215@2|Bacteria,2G8FQ@200795|Chloroflexi	200795|Chloroflexi	M	Glycosyl transferase family 21	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3
HKD2_k127_5936410_0	134676.ACPL_3102	6.131e-94	317.0	COG1216@1|root,COG1216@2|Bacteria,2I5Z7@201174|Actinobacteria,4DFNY@85008|Micromonosporales	201174|Actinobacteria	S	Glycosyltransferase like family 2	-	-	2.4.1.289	ko:K16870	-	-	-	-	ko00000,ko01000,ko01003	-	-	-	Glyco_tranf_2_3,Glyco_trans_1_4,Glycos_transf_2
HKD2_k127_5945819_5	656024.FsymDg_0673	1.015e-103	341.0	COG0302@1|root,COG0302@2|Bacteria,2GP2P@201174|Actinobacteria,4ERHB@85013|Frankiales	201174|Actinobacteria	H	GTP cyclohydrolase	folE	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003933,GO:0003934,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006066,GO:0006725,GO:0006729,GO:0006732,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009108,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019238,GO:0019438,GO:0019751,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034311,GO:0034312,GO:0034641,GO:0035639,GO:0036094,GO:0040007,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	3.5.4.16	ko:K01495	ko00790,ko01100,map00790,map01100	M00126,M00841,M00842,M00843	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv3609c	GTP_cyclohydroI
HKD2_k127_5945819_0	326424.FRAAL4235	1.065e-247	785.0	COG2898@1|root,COG2898@2|Bacteria,2I2ZR@201174|Actinobacteria,4ETDB@85013|Frankiales	201174|Actinobacteria	S	Uncharacterised conserved protein (DUF2156)	-	-	2.3.2.3,6.1.1.6	ko:K04567,ko:K14205	ko00970,ko01503,ko02020,ko05150,map00970,map01503,map02020,map05150	M00359,M00360,M00726	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko01504,ko03016	2.A.1.3.37	-	-	DUF2156,tRNA-synt_2_TM
HKD2_k127_5945819_3	656024.FsymDg_0237	9.837e-112	381.0	COG0294@1|root,COG0294@2|Bacteria,2GJDQ@201174|Actinobacteria,4ERRW@85013|Frankiales	201174|Actinobacteria	H	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives	folP	-	2.5.1.15	ko:K00796	ko00790,ko01100,map00790,map01100	M00126,M00841	R03066,R03067	RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
HKD2_k127_5945819_16	656024.FsymDg_0238	5.047e-38	145.0	COG1539@1|root,COG1539@2|Bacteria,2IHSW@201174|Actinobacteria,4ET0G@85013|Frankiales	201174|Actinobacteria	H	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin	folB	GO:0008150,GO:0040007	1.13.11.81,2.7.6.3,4.1.2.25,5.1.99.8	ko:K01633,ko:K13940	ko00790,ko01100,map00790,map01100	M00126,M00840	R03503,R03504,R11037,R11073	RC00002,RC00017,RC00721,RC00943,RC01479,RC03333,RC03334	ko00000,ko00001,ko00002,ko01000	-	-	-	FolB
HKD2_k127_5945819_13	656024.FsymDg_0239	1.567e-54	209.0	COG0801@1|root,COG0801@2|Bacteria,2H3G6@201174|Actinobacteria,4ESYM@85013|Frankiales	201174|Actinobacteria	H	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK)	folK	-	2.7.6.3,4.1.2.25	ko:K00950,ko:K13940	ko00790,ko01100,map00790,map01100	M00126,M00841	R03503,R03504	RC00002,RC00017,RC00721,RC00943	ko00000,ko00001,ko00002,ko01000	-	-	-	FolB,HPPK
HKD2_k127_5945819_15	656024.FsymDg_0240	2.375e-49	187.0	2DRQG@1|root,33CMQ@2|Bacteria,2IFEG@201174|Actinobacteria,4ETDT@85013|Frankiales	201174|Actinobacteria	S	Protein of unknown function (DUF3180)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3180
HKD2_k127_5945819_4	1120948.KB903229_gene5320	4.258e-104	355.0	29BBV@1|root,2ZYA6@2|Bacteria,2ICWN@201174|Actinobacteria	201174|Actinobacteria	S	Phosphodiester glycosidase	-	-	-	-	-	-	-	-	-	-	-	-	NAGPA
HKD2_k127_5945819_7	436229.JOEH01000004_gene84	2.534e-74	265.0	COG0382@1|root,COG0382@2|Bacteria,2GJ6P@201174|Actinobacteria,2NHZE@228398|Streptacidiphilus	201174|Actinobacteria	H	UbiA prenyltransferase family	ubiA	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006629,GO:0006643,GO:0006664,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0016763,GO:0031224,GO:0031226,GO:0040007,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044425,GO:0044459,GO:0044464,GO:0046467,GO:0046872,GO:0052636,GO:0071704,GO:0071944,GO:1901135,GO:1901137,GO:1901576,GO:1903509	2.4.2.45	ko:K14136	-	-	R10095	RC00005	ko00000,ko01000,ko01006	-	-	-	UbiA
HKD2_k127_5945819_1	1449355.JQNR01000005_gene3820	8.362e-184	600.0	COG0277@1|root,COG0277@2|Bacteria	2|Bacteria	C	FAD linked oxidase domain protein	dprE1	GO:0000271,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0005976,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010383,GO:0016020,GO:0016051,GO:0031221,GO:0033692,GO:0034637,GO:0034645,GO:0035884,GO:0040007,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044464,GO:0070589,GO:0070592,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:1901576	1.1.98.3	ko:K16653	-	-	-	-	ko00000,ko01000	-	-	-	ALO,FAD_binding_4
HKD2_k127_5945819_9	1463936.JOJI01000013_gene4686	4.734e-66	234.0	COG0300@1|root,COG0300@2|Bacteria,2GNPI@201174|Actinobacteria	201174|Actinobacteria	S	Dehydrogenases with different specificities (Related to short-chain alcohol dehydrogenases)	phbB	-	1.1.1.333	ko:K16652	-	-	-	-	ko00000,ko01000	-	-	-	adh_short
HKD2_k127_5945819_2	1123322.KB904702_gene164	1.639e-163	524.0	COG0517@1|root,COG1125@1|root,COG0517@2|Bacteria,COG1125@2|Bacteria,2GJHI@201174|Actinobacteria	201174|Actinobacteria	E	ABC transporter	opuCA	-	-	ko:K05847	ko02010,map02010	M00209	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	ABC_tran
HKD2_k127_5945819_10	1463861.JNXE01000027_gene3391	3.375e-63	224.0	COG1174@1|root,COG1174@2|Bacteria,2GMU0@201174|Actinobacteria	201174|Actinobacteria	E	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K05846	ko02010,map02010	M00209	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	BPD_transp_1
HKD2_k127_5945819_8	1123320.KB889585_gene1790	7.148e-68	241.0	COG1174@1|root,COG1174@2|Bacteria,2GYTC@201174|Actinobacteria	201174|Actinobacteria	E	ABC transporter (Permease)	proW	-	-	ko:K05846	ko02010,map02010	M00209	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	BPD_transp_1
HKD2_k127_5945819_11	1223523.H340_05574	3.687e-63	238.0	COG1732@1|root,COG1732@2|Bacteria,2GJWY@201174|Actinobacteria	201174|Actinobacteria	M	Glycine betaine	-	-	-	ko:K05845	ko02010,map02010	M00209	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	OpuAC
HKD2_k127_5945819_6	1449347.JQLN01000005_gene3499	1.835e-77	262.0	COG1569@1|root,COG1569@2|Bacteria,2HZNY@201174|Actinobacteria,2M5W4@2063|Kitasatospora	201174|Actinobacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN_3
HKD2_k127_5945819_12	1146883.BLASA_0251	5.333e-55	196.0	COG3311@1|root,COG3311@2|Bacteria,2IQFY@201174|Actinobacteria	201174|Actinobacteria	K	DNA binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_17
HKD2_k127_5945819_14	1001240.GY21_15160	1.034e-53	191.0	COG4113@1|root,COG4113@2|Bacteria,2GR4U@201174|Actinobacteria,4FQIB@85023|Microbacteriaceae	201174|Actinobacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
HKD2_k127_5945819_17	1121924.ATWH01000013_gene562	4.229e-24	103.0	2DR8X@1|root,33AQM@2|Bacteria,2GWFC@201174|Actinobacteria,4FQS0@85023|Microbacteriaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6023721_1	1449353.JQMQ01000005_gene3911	8.456e-23	101.0	2EZ4I@1|root,33SAQ@2|Bacteria,2GQT2@201174|Actinobacteria,2NFHP@228398|Streptacidiphilus	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6023721_0	656024.FsymDg_1096	4.501e-240	747.0	COG0499@1|root,COG0499@2|Bacteria,2GK2Q@201174|Actinobacteria,4EU61@85013|Frankiales	201174|Actinobacteria	H	S-adenosyl-L-homocysteine hydrolase, NAD binding domain	ahcY	-	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
HKD2_k127_6023721_2	222534.KB893683_gene1139	5.305e-05	49.0	COG0744@1|root,COG0744@2|Bacteria,2GK21@201174|Actinobacteria,4ERGQ@85013|Frankiales	201174|Actinobacteria	M	PFAM glycosyl transferase, family 51	pon1	-	-	-	-	-	-	-	-	-	-	-	PASTA,Transgly,Transpeptidase
HKD2_k127_6032438_1	326424.FRAAL6736	1.046e-110	368.0	COG0266@1|root,COG0266@2|Bacteria,2GKAM@201174|Actinobacteria,4ERRN@85013|Frankiales	201174|Actinobacteria	L	Belongs to the FPG family	mutM1	-	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
HKD2_k127_6032438_7	1449346.JQMO01000003_gene5992	1.56e-29	124.0	COG0589@1|root,COG0589@2|Bacteria,2IQPQ@201174|Actinobacteria,2M3NK@2063|Kitasatospora	201174|Actinobacteria	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD2_k127_6032438_2	512565.AMIS_38570	1.714e-94	331.0	COG0738@1|root,COG0738@2|Bacteria,2GRCY@201174|Actinobacteria,4DME8@85008|Micromonosporales	201174|Actinobacteria	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD2_k127_6032438_0	365528.KB891212_gene2276	3.402e-179	573.0	COG0579@1|root,COG0579@2|Bacteria,2GKFB@201174|Actinobacteria,4ETP5@85013|Frankiales	201174|Actinobacteria	S	FAD dependent oxidoreductase	-	-	-	ko:K15736	-	-	-	-	ko00000,ko01000	-	-	-	DAO,NAD_binding_8
HKD2_k127_6032438_5	512565.AMIS_39550	1.656e-66	236.0	COG2339@1|root,COG2339@2|Bacteria,2I9NJ@201174|Actinobacteria,4DC21@85008|Micromonosporales	201174|Actinobacteria	S	Protease prsW family	-	-	-	-	-	-	-	-	-	-	-	-	PrsW-protease
HKD2_k127_6032438_4	208439.AJAP_30615	1.948e-82	281.0	COG0745@1|root,COG0745@2|Bacteria,2GP1I@201174|Actinobacteria,4E0M1@85010|Pseudonocardiales	201174|Actinobacteria	T	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
HKD2_k127_6032438_3	1120936.KB907209_gene1435	1.631e-87	310.0	COG0642@1|root,COG0642@2|Bacteria,2GJIV@201174|Actinobacteria,4EMMS@85012|Streptosporangiales	201174|Actinobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
HKD2_k127_6032438_8	1380390.JIAT01000013_gene25	2.9e-06	55.0	294BJ@1|root,2ZFRD@2|Bacteria,2HRN0@201174|Actinobacteria,4CTQ2@84995|Rubrobacteria	84995|Rubrobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6032438_6	330084.JNYZ01000001_gene3053	5.14e-41	162.0	COG2382@1|root,COG2382@2|Bacteria,2I2KB@201174|Actinobacteria,4E14A@85010|Pseudonocardiales	201174|Actinobacteria	P	Putative esterase	-	-	-	-	-	-	-	-	-	-	-	-	Esterase
HKD2_k127_6034726_4	100226.SCO3736	3.483e-34	151.0	COG1595@1|root,COG1595@2|Bacteria,2GP65@201174|Actinobacteria	201174|Actinobacteria	K	belongs to the sigma-70 factor family, ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD2_k127_6034726_2	298653.Franean1_1933	1.106e-98	344.0	COG0159@1|root,COG0159@2|Bacteria,2GN6T@201174|Actinobacteria,4ERZA@85013|Frankiales	201174|Actinobacteria	E	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate	trpA	-	4.2.1.20	ko:K01695	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_syntA
HKD2_k127_6034726_0	326424.FRAAL4968	1.807e-204	658.0	COG0133@1|root,COG0133@2|Bacteria,2GM7Z@201174|Actinobacteria,4ERSM@85013|Frankiales	201174|Actinobacteria	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB	GO:0000162,GO:0003674,GO:0003824,GO:0004834,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0040007,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.2.1.20	ko:K01696	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPS,PALP
HKD2_k127_6034726_1	656024.FsymDg_2818	5.298e-122	406.0	COG0134@1|root,COG0134@2|Bacteria,2GIVV@201174|Actinobacteria,4ERMN@85013|Frankiales	201174|Actinobacteria	E	Belongs to the TrpC family	trpC	GO:0000162,GO:0000287,GO:0003674,GO:0003824,GO:0004425,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016020,GO:0016053,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019752,GO:0030312,GO:0034641,GO:0040007,GO:0042401,GO:0042430,GO:0042435,GO:0043167,GO:0043169,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046219,GO:0046391,GO:0046394,GO:0046483,GO:0046872,GO:0071704,GO:0071944,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.1.1.48	ko:K01609	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03508	RC00944	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPS
HKD2_k127_6034726_3	1463825.JNXC01000005_gene2493	1.314e-65	228.0	COG5002@1|root,COG5002@2|Bacteria,2GMH4@201174|Actinobacteria,4DYQ6@85010|Pseudonocardiales	201174|Actinobacteria	T	His Kinase A (phosphoacceptor) domain	baeS	-	2.7.13.3	ko:K07642	ko02020,map02020	M00450,M00645,M00646,M00648	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
HKD2_k127_6063901_5	469383.Cwoe_2021	4.155e-17	89.0	COG4113@1|root,COG4113@2|Bacteria	469383.Cwoe_2021|-	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6063901_0	471852.Tcur_3224	4.272e-256	803.0	COG0423@1|root,COG0423@2|Bacteria,2GIT3@201174|Actinobacteria,4EI01@85012|Streptosporangiales	201174|Actinobacteria	J	Catalyzes the attachment of glycine to tRNA(Gly)	glyQS	GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006426,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046983,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.14	ko:K01880	ko00970,map00970	M00359,M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	HGTP_anticodon,tRNA-synt_2b
HKD2_k127_6063901_2	1463926.JOCA01000025_gene6936	1.766e-68	244.0	COG3576@1|root,COG3576@2|Bacteria,2GP9M@201174|Actinobacteria	201174|Actinobacteria	C	pyridoxamine 5-phosphate	-	-	-	ko:K07006	-	-	-	-	ko00000	-	-	-	Putative_PNPOx
HKD2_k127_6063901_3	66897.DJ64_34045	4.293e-57	202.0	COG0346@1|root,COG0346@2|Bacteria,2IHXI@201174|Actinobacteria	201174|Actinobacteria	E	glyoxalase bleomycin resistance protein dioxygenase	-	-	4.4.1.5	ko:K01759	ko00620,map00620	-	R02530	RC00004,RC00740	ko00000,ko00001,ko01000	-	-	-	Glyoxalase
HKD2_k127_6063901_4	44060.JODL01000010_gene1615	3.474e-52	190.0	COG5516@1|root,COG5516@2|Bacteria,2ID3R@201174|Actinobacteria	201174|Actinobacteria	S	Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding	-	-	-	-	-	-	-	-	-	-	-	-	ABATE,zf-CGNR
HKD2_k127_6063901_6	28444.JODQ01000001_gene2526	1.472e-11	70.0	2C98I@1|root,33EGA@2|Bacteria,2IQRU@201174|Actinobacteria,4EKFZ@85012|Streptosporangiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6063901_1	326424.FRAAL2017	3.062e-109	356.0	COG0020@1|root,COG0020@2|Bacteria,2GIXF@201174|Actinobacteria,4ERUY@85013|Frankiales	201174|Actinobacteria	I	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids	uppS	GO:0000287,GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008834,GO:0009058,GO:0009987,GO:0016020,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0030145,GO:0033850,GO:0040007,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0046872,GO:0046914,GO:0050347,GO:0071704,GO:0071944,GO:1901576,GO:1901615,GO:1901617	2.5.1.31,2.5.1.86,2.5.1.88	ko:K00806,ko:K14215,ko:K21273	ko00900,ko01110,map00900,map01110	-	R06447,R09244,R09731	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
HKD2_k127_6099980_6	1463861.JNXE01000001_gene5237	1.204e-16	82.0	COG1136@1|root,COG1136@2|Bacteria,2GJN6@201174|Actinobacteria	201174|Actinobacteria	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD2_k127_6099980_3	1120950.KB892743_gene3115	9.102e-88	313.0	COG2197@1|root,COG2197@2|Bacteria,2GJ46@201174|Actinobacteria,4DNBB@85009|Propionibacteriales	201174|Actinobacteria	T	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HKD2_k127_6099980_2	1463856.JOHY01000005_gene1984	2.242e-91	315.0	COG4585@1|root,COG4585@2|Bacteria,2GKV2@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
HKD2_k127_6099980_0	103733.JNYO01000001_gene123	2.955e-161	522.0	COG1252@1|root,COG1252@2|Bacteria,2GJFE@201174|Actinobacteria,4DXY1@85010|Pseudonocardiales	201174|Actinobacteria	C	Pyridine nucleotide-disulphide oxidoreductase	ndh1	-	1.6.99.3	ko:K03885	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
HKD2_k127_6099980_4	1223523.H340_21671	3.647e-53	196.0	COG0847@1|root,COG0847@2|Bacteria,2I2KI@201174|Actinobacteria	201174|Actinobacteria	L	DNA polymerase III	dnaQ	-	2.7.7.7	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	RNase_T
HKD2_k127_6099980_7	1306990.BARG01000034_gene4107	6.18e-14	83.0	COG3795@1|root,COG3795@2|Bacteria,2INCW@201174|Actinobacteria	201174|Actinobacteria	S	YCII-related domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6099980_1	208439.AJAP_18030	8.907e-117	404.0	COG1595@1|root,COG1595@2|Bacteria,2GMRK@201174|Actinobacteria,4E85Q@85010|Pseudonocardiales	201174|Actinobacteria	K	SnoaL-like domain	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2,SnoaL_2
HKD2_k127_6099980_5	1304865.JAGF01000001_gene128	4.272e-40	152.0	COG1277@1|root,COG1277@2|Bacteria,2GP6D@201174|Actinobacteria	201174|Actinobacteria	S	ABC transporter (Permease)	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2,ABC2_membrane_4
HKD2_k127_6145197_9	222534.KB893715_gene1693	1.206e-05	47.0	COG5421@1|root,COG5421@2|Bacteria,2GK2A@201174|Actinobacteria	201174|Actinobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
HKD2_k127_6145197_5	1206731.BAGB01000145_gene4198	4.855e-17	86.0	COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,2I1D3@201174|Actinobacteria,4G7XC@85025|Nocardiaceae	201174|Actinobacteria	L	Winged helix-turn helix	-	-	-	-	-	-	-	-	-	-	-	-	HTH_33
HKD2_k127_6145197_4	1120950.KB892806_gene1533	3.886e-28	123.0	COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,2IAHV@201174|Actinobacteria,4DUEP@85009|Propionibacteriales	201174|Actinobacteria	L	Winged helix-turn helix	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_28,HTH_32,HTH_33
HKD2_k127_6145197_6	656024.FsymDg_0505	3.413e-16	81.0	COG5305@1|root,COG5305@2|Bacteria,2IDAQ@201174|Actinobacteria,4EW9F@85013|Frankiales	201174|Actinobacteria	S	Predicted membrane protein (DUF2142)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2142
HKD2_k127_6145197_0	656024.FsymDg_0505	5.821e-97	327.0	COG5305@1|root,COG5305@2|Bacteria,2IDAQ@201174|Actinobacteria,4EW9F@85013|Frankiales	201174|Actinobacteria	S	Predicted membrane protein (DUF2142)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2142
HKD2_k127_6145197_7	656024.FsymDg_0505	7.17e-15	87.0	COG5305@1|root,COG5305@2|Bacteria,2IDAQ@201174|Actinobacteria,4EW9F@85013|Frankiales	201174|Actinobacteria	S	Predicted membrane protein (DUF2142)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2142
HKD2_k127_6145197_1	1380356.JNIK01000003_gene1241	5.789e-95	321.0	2DBF5@1|root,2Z8WM@2|Bacteria,2GNTC@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6145197_3	106370.Francci3_1920	4.162e-48	181.0	COG0071@1|root,COG0071@2|Bacteria,2IRG0@201174|Actinobacteria,4ET0C@85013|Frankiales	201174|Actinobacteria	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
HKD2_k127_6145197_2	1323361.JPOC01000007_gene457	7.109e-56	209.0	COG2141@1|root,COG2141@2|Bacteria,2GKRH@201174|Actinobacteria,4FZAN@85025|Nocardiaceae	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
HKD2_k127_6145197_8	1095767.CAHD01000209_gene122	2.581e-14	82.0	COG0277@1|root,COG2141@1|root,COG0277@2|Bacteria,COG2141@2|Bacteria,2GKRH@201174|Actinobacteria	201174|Actinobacteria	C	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	BBE,Bac_luciferase,FAD_binding_4,Hemerythrin
HKD2_k127_6145197_10	926690.KE386573_gene2945	0.0008264	43.0	COG0265@1|root,arCOG02833@2157|Archaea,2XT7Y@28890|Euryarchaeota,23SJ4@183963|Halobacteria	183963|Halobacteria	O	COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
HKD2_k127_6184448_4	479431.Namu_4774	2.816e-34	139.0	2E40M@1|root,32YXE@2|Bacteria,2GRE0@201174|Actinobacteria,4ETBG@85013|Frankiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6184448_2	298655.KI912266_gene1469	1.224e-148	478.0	COG0604@1|root,COG0604@2|Bacteria,2GN47@201174|Actinobacteria,4ERXU@85013|Frankiales	201174|Actinobacteria	C	PFAM Alcohol dehydrogenase zinc-binding domain protein	-	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N,ADH_zinc_N_2
HKD2_k127_6184448_3	710111.FraQA3DRAFT_5123	7.206e-65	227.0	291ZT@1|root,2ZPJ4@2|Bacteria,2GR7R@201174|Actinobacteria,4ESN9@85013|Frankiales	201174|Actinobacteria	S	Protein of unknown function (DUF2587)	bpa	GO:0000502,GO:0003674,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0008150,GO:0009893,GO:0009894,GO:0009896,GO:0009987,GO:0010604,GO:0016020,GO:0016043,GO:0019222,GO:0022607,GO:0022624,GO:0030162,GO:0030312,GO:0031323,GO:0031325,GO:0031329,GO:0031331,GO:0032268,GO:0032270,GO:0032991,GO:0042176,GO:0043933,GO:0044085,GO:0044424,GO:0044464,GO:0044877,GO:0045732,GO:0045862,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0051259,GO:0051260,GO:0060255,GO:0061136,GO:0065003,GO:0065007,GO:0070628,GO:0071840,GO:0071944,GO:0080090,GO:1901800,GO:1902494,GO:1903050,GO:1903052,GO:1903362,GO:1903364,GO:1905368,GO:1905369	-	-	-	-	-	-	-	-	-	-	DUF2587
HKD2_k127_6184448_1	298654.FraEuI1c_0292	6.548e-194	637.0	COG0312@1|root,COG0312@2|Bacteria,2GZPS@201174|Actinobacteria,4ES19@85013|Frankiales	201174|Actinobacteria	S	Putative modulator of DNA gyrase	-	-	-	-	-	-	-	-	-	-	-	-	PmbA_TldD
HKD2_k127_6184448_0	656024.FsymDg_0669	7.688e-263	816.0	COG0312@1|root,COG0312@2|Bacteria,2GJ4E@201174|Actinobacteria,4ERBS@85013|Frankiales	201174|Actinobacteria	S	peptidase U62, modulator of DNA gyrase	tldD	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
HKD2_k127_6184448_5	365528.KB891285_gene5027	6.268e-29	117.0	COG0561@1|root,COG0561@2|Bacteria,2GP42@201174|Actinobacteria,4ESRA@85013|Frankiales	201174|Actinobacteria	S	HAD-superfamily hydrolase, subfamily IIB	cof	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_3
HKD2_k127_6200546_4	479431.Namu_2557	1.341e-12	68.0	COG1765@1|root,COG1765@2|Bacteria,2IFY4@201174|Actinobacteria,4ET1W@85013|Frankiales	201174|Actinobacteria	O	PFAM OsmC family protein	-	-	-	-	-	-	-	-	-	-	-	-	OsmC
HKD2_k127_6200546_0	1101188.KI912155_gene2593	2.376e-128	423.0	COG0477@1|root,COG0477@2|Bacteria,2GIUM@201174|Actinobacteria,1W80B@1268|Micrococcaceae	201174|Actinobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD2_k127_6200546_3	106370.Francci3_2291	1.171e-42	173.0	COG1846@1|root,COG1846@2|Bacteria,2IK59@201174|Actinobacteria,4ETH0@85013|Frankiales	201174|Actinobacteria	K	PFAM regulatory protein, MarR	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
HKD2_k127_6200546_1	675635.Psed_4080	1.103e-109	366.0	COG2890@1|root,COG2890@2|Bacteria,2GITA@201174|Actinobacteria,4E0ST@85010|Pseudonocardiales	201174|Actinobacteria	J	S-adenosyl methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_19
HKD2_k127_6200546_2	222534.KB893770_gene4750	7.348e-55	212.0	COG0607@1|root,COG0607@2|Bacteria,2IB6H@201174|Actinobacteria,4ET0Z@85013|Frankiales	201174|Actinobacteria	P	Protein of unknown function (DUF2892)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2892,Rhodanese
HKD2_k127_6365390_2	656024.FsymDg_3666	3.937e-29	134.0	COG0758@1|root,COG0758@2|Bacteria,2GKDA@201174|Actinobacteria,4ESKB@85013|Frankiales	201174|Actinobacteria	LU	DNA protecting protein DprA	dprA	-	-	ko:K04096	-	-	-	-	ko00000	-	-	-	DNA_processg_A
HKD2_k127_6365390_0	365528.KB891241_gene6156	1.402e-216	687.0	COG0606@1|root,COG0606@2|Bacteria,2GJIQ@201174|Actinobacteria,4ERBP@85013|Frankiales	201174|Actinobacteria	O	PFAM Magnesium chelatase, ChlI subunit	comM	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	-	ko:K07391	-	-	-	-	ko00000	-	-	-	ChlI,Mg_chelatase,Mg_chelatase_C
HKD2_k127_6365390_1	1120950.KB892769_gene5382	6.804e-32	132.0	COG0792@1|root,COG0792@2|Bacteria,2IQ3X@201174|Actinobacteria,4DRQN@85009|Propionibacteriales	201174|Actinobacteria	L	Belongs to the UPF0102 family	yraN	-	-	ko:K07460	-	-	-	-	ko00000	-	-	-	UPF0102
HKD2_k127_6365390_3	298655.KI912267_gene6703	2.269e-16	78.0	2AFXT@1|root,3161G@2|Bacteria,2IKPZ@201174|Actinobacteria,4ESTD@85013|Frankiales	201174|Actinobacteria	S	Protein of unknown function (DUF2469)	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DUF2469
HKD2_k127_6381578_4	222534.KB893670_gene3784	1.315e-88	303.0	COG2845@1|root,COG2845@2|Bacteria,2GU62@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF459)	-	-	-	ko:K09795	-	-	-	-	ko00000	-	-	-	DUF459
HKD2_k127_6381578_8	1380390.JIAT01000010_gene3953	1.764e-19	104.0	COG1807@1|root,COG1807@2|Bacteria	2|Bacteria	M	4-amino-4-deoxy-L-arabinose transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HKD2_k127_6381578_0	656024.FsymDg_0714	4.052e-248	771.0	COG0031@1|root,COG3620@1|root,COG0031@2|Bacteria,COG3620@2|Bacteria,2GIXE@201174|Actinobacteria,4ERI6@85013|Frankiales	201174|Actinobacteria	EK	Cystathionine beta-synthase	cbs	GO:0003674,GO:0005488,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008144,GO:0016020,GO:0019842,GO:0030170,GO:0030312,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0048037,GO:0050662,GO:0070279,GO:0071944,GO:0097159,GO:1901363	4.2.1.22	ko:K01697	ko00260,ko00270,ko01100,ko01130,ko01230,map00260,map00270,map01100,map01130,map01230	M00035,M00338	R00891,R01290,R04942	RC00056,RC00069,RC00256,RC00489,RC01246	ko00000,ko00001,ko00002,ko01000	-	-	-	CBS,PALP
HKD2_k127_6381578_7	656024.FsymDg_0767	4.53e-27	117.0	2E5A7@1|root,3302F@2|Bacteria,2IQ7Z@201174|Actinobacteria,4EX1N@85013|Frankiales	201174|Actinobacteria	S	Domain of unknown function (DUF4287)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4287
HKD2_k127_6381578_5	656024.FsymDg_0766	1.007e-63	220.0	COG3576@1|root,COG3576@2|Bacteria,2I3PF@201174|Actinobacteria,4EXBZ@85013|Frankiales	201174|Actinobacteria	S	Pfam:Pyridox_oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
HKD2_k127_6381578_9	1379270.AUXF01000006_gene91	2.257e-15	91.0	COG1570@1|root,COG1570@2|Bacteria,1ZT8T@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseA	-	3.1.11.6	ko:K03601	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_L,tRNA_anti_2
HKD2_k127_6381578_2	35754.JNYJ01000042_gene1378	1.083e-149	501.0	COG0309@1|root,COG0309@2|Bacteria,2GJ7N@201174|Actinobacteria,4DHG8@85008|Micromonosporales	201174|Actinobacteria	O	AIR synthase related protein, C-terminal domain	hypE	-	-	ko:K04655	-	-	-	-	ko00000	-	-	-	AIRS,AIRS_C
HKD2_k127_6381578_1	35754.JNYJ01000042_gene1379	1.061e-186	590.0	COG0409@1|root,COG0409@2|Bacteria,2GMHA@201174|Actinobacteria,4DGUE@85008|Micromonosporales	201174|Actinobacteria	O	Hydrogenase formation hypA family	hypD	-	-	ko:K04654	-	-	-	-	ko00000	-	-	-	HypD
HKD2_k127_6381578_6	1156844.KB891798_gene6214	7.991e-29	118.0	COG0298@1|root,COG0298@2|Bacteria,2IMSQ@201174|Actinobacteria	201174|Actinobacteria	O	Hydrogenase expression formation protein	-	-	-	ko:K04653	-	-	-	-	ko00000	-	-	-	HupF_HypC
HKD2_k127_6381578_3	656024.FsymDg_0765	1.609e-117	383.0	COG4760@1|root,COG4760@2|Bacteria,2GNCK@201174|Actinobacteria,4ESTG@85013|Frankiales	201174|Actinobacteria	S	Bax inhibitor 1 like	-	-	-	-	-	-	-	-	-	-	-	-	BaxI_1
HKD2_k127_6382819_3	106370.Francci3_1234	1.588e-38	154.0	COG0406@1|root,COG0406@2|Bacteria,2GJYU@201174|Actinobacteria,4ESZJ@85013|Frankiales	201174|Actinobacteria	G	phosphoglycerate mutase	gpmB	GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0042578,GO:0044237	3.1.3.85,5.4.2.11	ko:K01834,ko:K22306	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	His_Phos_1
HKD2_k127_6382819_2	656024.FsymDg_1554	3.365e-54	197.0	COG0799@1|root,COG0799@2|Bacteria,2IKZ3@201174|Actinobacteria,4ESRQ@85013|Frankiales	201174|Actinobacteria	S	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation	rsfS	-	-	ko:K09710	-	-	-	-	ko00000,ko03009	-	-	-	RsfS
HKD2_k127_6382819_1	298654.FraEuI1c_1983	1.439e-95	317.0	COG1057@1|root,COG1057@2|Bacteria,2GMFZ@201174|Actinobacteria,4ESGS@85013|Frankiales	201174|Actinobacteria	H	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)	nadD	GO:0000309,GO:0003674,GO:0003824,GO:0004515,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0040007,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	2.7.7.18	ko:K00969	ko00760,ko01100,map00760,map01100	M00115	R00137,R03005	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
HKD2_k127_6382819_4	29306.JOBE01000030_gene906	6.694e-23	104.0	COG0508@1|root,COG0508@2|Bacteria,2GQQK@201174|Actinobacteria	201174|Actinobacteria	C	dehydrogenase complex catalyzes the overall conversion of	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6382819_0	1254432.SCE1572_33235	4.738e-226	717.0	COG0033@1|root,COG0033@2|Bacteria,1MU5S@1224|Proteobacteria,42M9F@68525|delta/epsilon subdivisions,2WJNB@28221|Deltaproteobacteria,2YU00@29|Myxococcales	28221|Deltaproteobacteria	G	Phosphoglucomutase/phosphomannomutase, C-terminal domain	pgm	-	5.4.2.2	ko:K01835	ko00010,ko00030,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00549	R00959,R01057,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
HKD2_k127_6414620_2	106370.Francci3_2493	7.645e-32	129.0	COG0843@1|root,COG0843@2|Bacteria,2GJHX@201174|Actinobacteria,4ES0K@85013|Frankiales	201174|Actinobacteria	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	-	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
HKD2_k127_6414620_1	326424.FRAAL0157	8.263e-77	270.0	COG0697@1|root,COG0697@2|Bacteria,2H9P8@201174|Actinobacteria,4ETBW@85013|Frankiales	201174|Actinobacteria	EG	spore germination	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6414620_0	479431.Namu_1396	1.338e-154	514.0	COG0475@1|root,COG0475@2|Bacteria,2GIRC@201174|Actinobacteria,4EUDU@85013|Frankiales	201174|Actinobacteria	P	PFAM sodium hydrogen exchanger	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
HKD2_k127_6421074_0	298655.KI912266_gene1864	1.939e-232	724.0	COG1197@1|root,COG1197@2|Bacteria,2GJ42@201174|Actinobacteria,4ERK2@85013|Frankiales	201174|Actinobacteria	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
HKD2_k127_6421074_1	222534.KB893670_gene3796	2.531e-47	183.0	29917@1|root,2ZW4S@2|Bacteria	2|Bacteria	S	SurA N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	SurA_N_3
HKD2_k127_6421074_2	1348663.KCH_46730	2.309e-14	81.0	COG1694@1|root,COG3956@2|Bacteria,2GNKC@201174|Actinobacteria,2M0S2@2063|Kitasatospora	201174|Actinobacteria	S	MazG nucleotide pyrophosphohydrolase domain	mazG	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006213,GO:0006220,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009147,GO:0009149,GO:0009151,GO:0009155,GO:0009164,GO:0009166,GO:0009199,GO:0009200,GO:0009203,GO:0009204,GO:0009208,GO:0009210,GO:0009211,GO:0009213,GO:0009215,GO:0009217,GO:0009218,GO:0009219,GO:0009222,GO:0009223,GO:0009259,GO:0009261,GO:0009262,GO:0009264,GO:0009394,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0019693,GO:0022607,GO:0030312,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0035539,GO:0042454,GO:0043167,GO:0043169,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0044464,GO:0046046,GO:0046047,GO:0046051,GO:0046052,GO:0046060,GO:0046061,GO:0046070,GO:0046075,GO:0046076,GO:0046080,GO:0046081,GO:0046131,GO:0046133,GO:0046135,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0047429,GO:0047693,GO:0050896,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055086,GO:0065003,GO:0071704,GO:0071840,GO:0071944,GO:0072521,GO:0072523,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901657,GO:1901658	3.6.1.66	ko:K02428,ko:K02499	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000,ko03036	-	-	-	MazG
HKD2_k127_6431954_0	266940.Krad_3544	7.516e-172	563.0	COG5001@1|root,COG5001@2|Bacteria,2GIZF@201174|Actinobacteria	201174|Actinobacteria	T	signal transduction protein containing a membrane domain an EAL and a GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF
HKD2_k127_6431954_4	1385518.N798_08970	6.066e-26	116.0	COG2259@1|root,COG2259@2|Bacteria,2HD6Y@201174|Actinobacteria,4FGKG@85021|Intrasporangiaceae	201174|Actinobacteria	S	DoxX family	doxX	-	-	-	-	-	-	-	-	-	-	-	DoxX
HKD2_k127_6431954_1	67257.JODR01000022_gene5024	9.961e-116	392.0	COG0500@1|root,COG2226@2|Bacteria,2GM9H@201174|Actinobacteria	201174|Actinobacteria	Q	Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_23
HKD2_k127_6431954_3	164757.Mjls_2069	1.665e-39	171.0	COG0500@1|root,COG2226@2|Bacteria,2IGKC@201174|Actinobacteria,238UQ@1762|Mycobacteriaceae	201174|Actinobacteria	Q	Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
HKD2_k127_6431954_6	1108045.GORHZ_130_00010	2.788e-19	94.0	COG0577@1|root,COG0577@2|Bacteria,2GJTZ@201174|Actinobacteria,4GH7C@85026|Gordoniaceae	201174|Actinobacteria	V	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HKD2_k127_6431954_2	1380390.JIAT01000010_gene4015	6.695e-108	387.0	COG3127@1|root,COG3127@2|Bacteria,2H37M@201174|Actinobacteria,4CU4J@84995|Rubrobacteria	201174|Actinobacteria	Q	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HKD2_k127_6431954_7	266117.Rxyl_1740	3.33e-19	93.0	COG1846@1|root,COG1846@2|Bacteria,2IHYF@201174|Actinobacteria,4CQVQ@84995|Rubrobacteria	84995|Rubrobacteria	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
HKD2_k127_6431954_8	1463920.JOGB01000058_gene3993	1.587e-05	56.0	COG2197@1|root,COG2909@1|root,COG2197@2|Bacteria,COG2909@2|Bacteria,2GJIA@201174|Actinobacteria	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	GerE
HKD2_k127_6431954_5	1458275.AZ34_08005	2.044e-22	112.0	COG1075@1|root,COG1075@2|Bacteria,1QWJI@1224|Proteobacteria	1224|Proteobacteria	S	Alpha/beta hydrolase family	MA20_40150	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
HKD2_k127_6431954_9	232348.ADXL01000066_gene2730	0.0008796	48.0	COG3193@1|root,COG3193@2|Bacteria,1GRJX@1117|Cyanobacteria,1H1V8@1129|Synechococcus	1117|Cyanobacteria	S	Haem-degrading	-	-	-	-	-	-	-	-	-	-	-	-	Haem_degrading
HKD2_k127_6457150_3	656024.FsymDg_3895	1.027e-63	241.0	COG2185@1|root,COG2185@2|Bacteria,2IFJD@201174|Actinobacteria,4ESTR@85013|Frankiales	201174|Actinobacteria	I	Cobalamin B12-binding	icmB	-	5.4.99.2	ko:K01849	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding
HKD2_k127_6457150_1	298654.FraEuI1c_6163	2.738e-140	469.0	COG0777@1|root,COG0825@1|root,COG0777@2|Bacteria,COG0825@2|Bacteria,2GNP7@201174|Actinobacteria,4ETRB@85013|Frankiales	201174|Actinobacteria	I	carboxyl transferase	accD3	-	2.1.3.15,6.4.1.2	ko:K01962,ko:K01963	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	ACCA,Carboxyl_trans,MdcE
HKD2_k127_6457150_2	656024.FsymDg_3896	9.36e-101	338.0	COG1075@1|root,COG1075@2|Bacteria,2GMZA@201174|Actinobacteria,4EVBA@85013|Frankiales	201174|Actinobacteria	S	Lipase (class 2)	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,DUF676,PGAP1
HKD2_k127_6457150_4	656024.FsymDg_3897	9.075e-61	220.0	COG0739@1|root,COG0739@2|Bacteria,2GM7Q@201174|Actinobacteria,4EVUS@85013|Frankiales	201174|Actinobacteria	M	peptidase	mepA	-	-	ko:K21471	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_M23
HKD2_k127_6457150_0	710111.FraQA3DRAFT_3804	1.305e-185	587.0	COG0210@1|root,COG0210@2|Bacteria,2GISS@201174|Actinobacteria,4ERQH@85013|Frankiales	201174|Actinobacteria	L	ATP-dependent DNA helicase	pcrA	GO:0000018,GO:0000166,GO:0000287,GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009650,GO:0009892,GO:0009987,GO:0010605,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0030312,GO:0030554,GO:0031323,GO:0031324,GO:0032392,GO:0032508,GO:0032552,GO:0032554,GO:0032558,GO:0032564,GO:0032991,GO:0033202,GO:0033554,GO:0034641,GO:0036094,GO:0040007,GO:0042623,GO:0043138,GO:0043140,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0045910,GO:0045934,GO:0046483,GO:0046872,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0051276,GO:0051716,GO:0060255,GO:0060542,GO:0060543,GO:0065007,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0080090,GO:0090304,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363,GO:1902494	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
HKD2_k127_6471040_0	298653.Franean1_0155	0.0	1137.0	COG0046@1|root,COG0046@2|Bacteria,2GKG6@201174|Actinobacteria,4ERE3@85013|Frankiales	201174|Actinobacteria	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purL	GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009987,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
HKD2_k127_6471040_2	656024.FsymDg_0148	3.787e-111	363.0	COG0047@1|root,COG0047@2|Bacteria,2GMJY@201174|Actinobacteria,4ERSR@85013|Frankiales	201174|Actinobacteria	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purQ	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044424,GO:0044464,GO:0071944	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase_5
HKD2_k127_6471040_3	710111.FraQA3DRAFT_5019	3.736e-47	174.0	COG2172@1|root,COG2172@2|Bacteria,2IFV3@201174|Actinobacteria,4EW68@85013|Frankiales	201174|Actinobacteria	T	Histidine kinase-like ATPase domain	-	-	2.7.11.1	ko:K04757	-	-	-	-	ko00000,ko01000,ko01001,ko03021	-	-	-	HATPase_c_2
HKD2_k127_6471040_4	298653.Franean1_0148	3.251e-28	124.0	COG1828@1|root,COG1828@2|Bacteria,2GQV4@201174|Actinobacteria,4ET8E@85013|Frankiales	201174|Actinobacteria	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purS	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	PurS
HKD2_k127_6471040_1	298653.Franean1_0202	7.357e-144	461.0	COG0152@1|root,COG0152@2|Bacteria,2GK3H@201174|Actinobacteria,4ERID@85013|Frankiales	201174|Actinobacteria	F	SAICAR synthetase	purC	GO:0003674,GO:0003824,GO:0004639,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.2.6,6.3.4.13	ko:K01923,ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144,R04591	RC00064,RC00090,RC00162,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	SAICAR_synt
HKD2_k127_6482935_8	67275.JOAP01000009_gene3913	1.156e-66	243.0	COG1413@1|root,COG1413@2|Bacteria	2|Bacteria	C	deoxyhypusine monooxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554,HEAT_2,Paired_CXXCH_1,Peptidase_M56,TPR_19,TPR_8
HKD2_k127_6482935_11	1463903.JOIZ01000021_gene7123	1.118e-38	149.0	COG2402@1|root,COG2402@2|Bacteria,2IRQ5@201174|Actinobacteria	201174|Actinobacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	-	-	-	-	-	-	-	-	-	PIN
HKD2_k127_6482935_12	656024.FsymDg_4184	2.239e-38	158.0	COG0697@1|root,COG0697@2|Bacteria,2GXNN@201174|Actinobacteria	201174|Actinobacteria	EG	protein methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Mg_trans_NIPA
HKD2_k127_6482935_14	1206720.BAFQ01000293_gene6369	2.3e-23	117.0	COG0697@1|root,COG0697@2|Bacteria	2|Bacteria	EG	spore germination	-	-	-	-	-	-	-	-	-	-	-	-	EamA,Mg_trans_NIPA
HKD2_k127_6482935_1	656024.FsymDg_4185	5.79e-148	477.0	COG0707@1|root,COG0707@2|Bacteria,2GREI@201174|Actinobacteria,4EWT3@85013|Frankiales	201174|Actinobacteria	M	Monogalactosyldiacylglycerol (MGDG) synthase	-	-	-	-	-	-	-	-	-	-	-	-	DUF1298,Glyco_tran_28_C,Glyco_trans_1_4,MGDG_synth,WES_acyltransf
HKD2_k127_6482935_3	656024.FsymDg_4186	1.748e-122	403.0	COG0451@1|root,COG0451@2|Bacteria,2GK8K@201174|Actinobacteria	201174|Actinobacteria	GM	Epimerase dehydratase	-	-	5.1.3.2,5.1.3.25	ko:K01784,ko:K17947	ko00052,ko00520,ko00523,ko01100,ko01130,map00052,map00520,map00523,map01100,map01130	M00361,M00362,M00632	R00291,R02984,R10279	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
HKD2_k127_6482935_0	656024.FsymDg_4187	2.624e-167	533.0	COG0399@1|root,COG0399@2|Bacteria,2GKD7@201174|Actinobacteria,4ESWQ@85013|Frankiales	201174|Actinobacteria	E	Belongs to the DegT DnrJ EryC1 family	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
HKD2_k127_6482935_5	710111.FraQA3DRAFT_2773	9.722e-75	259.0	COG2197@1|root,COG2197@2|Bacteria,2GK4B@201174|Actinobacteria,4ESHE@85013|Frankiales	201174|Actinobacteria	T	Two component transcriptional regulator, LuxR family	-	-	-	ko:K07695	ko02020,map02020	M00482	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	GerE,Response_reg
HKD2_k127_6482935_6	105425.BBPL01000008_gene1597	1.587e-74	258.0	COG2197@1|root,COG2197@2|Bacteria,2GJKM@201174|Actinobacteria,2NEVP@228398|Streptacidiphilus	201174|Actinobacteria	T	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HKD2_k127_6482935_7	926554.KI912671_gene390	1.125e-73	274.0	COG2203@1|root,COG4585@1|root,COG2203@2|Bacteria,COG4585@2|Bacteria,1WM3F@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA_3,PAS_4,PAS_8
HKD2_k127_6482935_9	1173024.KI912149_gene5690	9.321e-48	194.0	COG0642@1|root,COG0745@1|root,COG0784@1|root,COG2202@1|root,COG2203@1|root,COG0745@2|Bacteria,COG0784@2|Bacteria,COG2202@2|Bacteria,COG2203@2|Bacteria,COG2205@2|Bacteria,1G09B@1117|Cyanobacteria,1JK6C@1189|Stigonemataceae	1117|Cyanobacteria	T	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg
HKD2_k127_6482935_2	670487.Ocepr_1903	1.782e-139	460.0	COG1509@1|root,COG1509@2|Bacteria,1WKKI@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	TIGRFAM KamA family protein	-	-	5.4.3.2	ko:K01843	ko00310,map00310	-	R00461	RC00303	ko00000,ko00001,ko01000	-	-	-	LAM_C,Radical_SAM
HKD2_k127_6482935_10	1123234.AUKI01000005_gene122	6.32e-46	186.0	COG0545@1|root,COG0652@1|root,COG0545@2|Bacteria,COG0652@2|Bacteria,4NDW4@976|Bacteroidetes,1HYBT@117743|Flavobacteriia	976|Bacteroidetes	O	Peptidyl-prolyl cis-trans isomerase	ppiC	-	5.2.1.8	ko:K01802,ko:K03767,ko:K03772	ko01503,ko04217,map01503,map04217	-	-	-	ko00000,ko00001,ko01000,ko03110,ko04147	-	-	-	FKBP_C,Pro_isomerase
HKD2_k127_6482935_4	656024.FsymDg_0184	6.656e-109	362.0	COG0705@1|root,COG0705@2|Bacteria,2GJYG@201174|Actinobacteria,4ESUX@85013|Frankiales	201174|Actinobacteria	NU	PFAM Rhomboid family	yggP	-	3.4.21.105	ko:K19225	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Rhomboid,zf-B_box
HKD2_k127_6482935_15	477641.MODMU_0019	1.414e-05	56.0	2ESQF@1|root,33K8W@2|Bacteria	2|Bacteria	S	Bacterial PH domain	-	-	-	-	-	-	-	-	-	-	-	-	bPH_6
HKD2_k127_6482935_13	749927.AMED_3855	1.851e-34	133.0	COG0183@1|root,COG0183@2|Bacteria,2GJAC@201174|Actinobacteria,4E0W6@85010|Pseudonocardiales	201174|Actinobacteria	I	Thiolase, C-terminal domain	-	-	2.3.1.16,2.3.1.9	ko:K00626,ko:K00632	ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00087,M00088,M00095,M00113,M00373,M00374,M00375	R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
HKD2_k127_6482990_7	1463934.JOCF01000091_gene2387	5.055e-30	126.0	COG1743@1|root,COG1743@2|Bacteria	2|Bacteria	L	DNA methylAse	-	-	-	ko:K07445	-	-	-	-	ko00000	-	-	-	HTH_31,N6_N4_Mtase
HKD2_k127_6482990_5	675635.Psed_6858	2.766e-51	186.0	COG3328@1|root,COG3328@2|Bacteria,2GM8F@201174|Actinobacteria,4DY23@85010|Pseudonocardiales	201174|Actinobacteria	L	PFAM Transposase, mutator type	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_mut
HKD2_k127_6482990_3	345341.KUTG_05615	1.96e-113	376.0	COG4748@1|root,COG4748@2|Bacteria	2|Bacteria	NT	type I restriction enzyme	-	-	-	ko:K07504	-	-	-	-	ko00000	-	-	-	AAA_31,HSDR_N,HSDR_N_2
HKD2_k127_6482990_8	40571.JOEA01000021_gene6880	9.881e-07	50.0	COG1961@1|root,COG1961@2|Bacteria,2GNGI@201174|Actinobacteria,4E13I@85010|Pseudonocardiales	201174|Actinobacteria	L	Recombinase	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
HKD2_k127_6482990_4	365528.KB891208_gene3118	1.286e-56	199.0	COG0745@1|root,COG0745@2|Bacteria,2I2Z1@201174|Actinobacteria,4ETFB@85013|Frankiales	201174|Actinobacteria	T	Response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
HKD2_k127_6482990_6	1380346.JNIH01000014_gene740	7.782e-50	191.0	2D9QC@1|root,32TTR@2|Bacteria,2IK1S@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6482990_0	298653.Franean1_1004	9.532e-251	783.0	COG0018@1|root,COG0018@2|Bacteria,2GKQ3@201174|Actinobacteria,4ERR2@85013|Frankiales	201174|Actinobacteria	J	Arginyl-tRNA synthetase	argS	GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
HKD2_k127_6482990_1	298654.FraEuI1c_0922	1.181e-220	718.0	COG0019@1|root,COG0019@2|Bacteria,2GKAI@201174|Actinobacteria,4ERM5@85013|Frankiales	201174|Actinobacteria	E	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine	lysA	-	4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
HKD2_k127_6482990_2	656024.FsymDg_3861	1.209e-118	408.0	COG0460@1|root,COG0460@2|Bacteria,2GIX9@201174|Actinobacteria,4ERJB@85013|Frankiales	201174|Actinobacteria	E	homoserine dehydrogenase	hom	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	1.1.1.3,2.7.2.4	ko:K00003,ko:K12524	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00017,M00018,M00526,M00527	R00480,R01773,R01775	RC00002,RC00043,RC00087	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv1294	ACT,Homoserine_dh,NAD_binding_3
HKD2_k127_6482992_3	65393.PCC7424_5840	5.885e-42	169.0	COG3344@1|root,COG3344@2|Bacteria,1G065@1117|Cyanobacteria,3KJKD@43988|Cyanothece	1117|Cyanobacteria	L	RNA-directed DNA polymerase	-	-	2.7.7.49	ko:K00986	-	-	-	-	ko00000,ko01000	-	-	-	GIIM,HNH,RVT_1,RVT_N
HKD2_k127_6482992_2	326427.Cagg_3451	8.269e-43	173.0	COG1518@1|root,COG1518@2|Bacteria,2G6AG@200795|Chloroflexi,376F7@32061|Chloroflexia	32061|Chloroflexia	L	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette	-	-	-	ko:K15342	-	-	-	-	ko00000,ko02048,ko03400	-	-	-	Cas_Cas1
HKD2_k127_6482992_6	869210.Marky_0189	0.0001373	48.0	COG1343@1|root,COG1343@2|Bacteria,1WKDC@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	L	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette	-	-	-	ko:K09951	-	-	-	-	ko00000,ko02048	-	-	-	CRISPR_Cas2
HKD2_k127_6482992_1	656024.FsymDg_4122	1.973e-57	210.0	COG5551@1|root,COG5551@2|Bacteria	2|Bacteria	S	defense response to virus	-	-	-	ko:K19091	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	CRISPR_Cas6
HKD2_k127_6482992_0	526225.Gobs_2555	3.31e-169	539.0	COG1180@1|root,COG1180@2|Bacteria	2|Bacteria	C	glycyl-radical enzyme activating activity	pflA	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
HKD2_k127_6489721_3	1120936.KB907214_gene4280	4.885e-56	199.0	COG2120@1|root,COG2120@2|Bacteria,2GMVD@201174|Actinobacteria,4EGBS@85012|Streptosporangiales	201174|Actinobacteria	S	GlcNAc-PI de-N-acetylase	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
HKD2_k127_6489721_2	65497.JODV01000001_gene3812	7.166e-86	309.0	COG0842@1|root,COG0842@2|Bacteria,2GP9E@201174|Actinobacteria,4E0GK@85010|Pseudonocardiales	201174|Actinobacteria	V	ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
HKD2_k127_6489721_1	526225.Gobs_0260	5.273e-126	416.0	COG1131@1|root,COG1131@2|Bacteria,2GIY8@201174|Actinobacteria	201174|Actinobacteria	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD2_k127_6489721_6	1121924.ATWH01000019_gene2952	1.117e-14	76.0	2BT7R@1|root,32ND4@2|Bacteria,2GVI3@201174|Actinobacteria,4FQQA@85023|Microbacteriaceae	201174|Actinobacteria	S	Ribbon-helix-helix protein, copG family	-	-	-	-	-	-	-	-	-	-	-	-	RHH_1
HKD2_k127_6489721_4	2074.JNYD01000003_gene3407	2e-25	113.0	COG1487@1|root,COG1487@2|Bacteria,2IR5C@201174|Actinobacteria	201174|Actinobacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
HKD2_k127_6489721_0	326424.FRAAL1150	2.738e-282	884.0	COG0518@1|root,COG0519@1|root,COG0518@2|Bacteria,COG0519@2|Bacteria,2GM09@201174|Actinobacteria,4ERBR@85013|Frankiales	201174|Actinobacteria	F	Catalyzes the synthesis of GMP from XMP	guaA	GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0034404,GO:0034641,GO:0034654,GO:0040007,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase,GMP_synt_C,NAD_synthase
HKD2_k127_6489721_5	222534.KB893748_gene2747	1.203e-24	111.0	COG3266@1|root,COG4251@1|root,COG3266@2|Bacteria,COG4251@2|Bacteria,2GK6E@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase	cvnA6	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,NIT
HKD2_k127_6508249_5	1206733.BAGC01000041_gene1955	3.233e-89	297.0	COG3227@1|root,COG3227@2|Bacteria,2GJEW@201174|Actinobacteria,4FY20@85025|Nocardiaceae	201174|Actinobacteria	E	Thermolysin metallopeptidase, catalytic domain	prt1	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M4,Peptidase_M4_C
HKD2_k127_6508249_12	1380347.JNII01000007_gene629	2.163e-33	130.0	COG3227@1|root,COG3227@2|Bacteria,2I0Z3@201174|Actinobacteria,4EWEA@85013|Frankiales	201174|Actinobacteria	E	Thermolysin metallopeptidase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M4,Peptidase_M4_C
HKD2_k127_6508249_4	469383.Cwoe_4697	2.408e-94	323.0	COG1028@1|root,COG1028@2|Bacteria,2GNUM@201174|Actinobacteria,4CPHJ@84995|Rubrobacteria	84995|Rubrobacteria	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HKD2_k127_6508249_10	106370.Francci3_1656	3.778e-42	164.0	COG1396@1|root,COG1396@2|Bacteria,2I569@201174|Actinobacteria,4ESCS@85013|Frankiales	201174|Actinobacteria	K	PFAM helix-turn-helix domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3,HTH_31
HKD2_k127_6508249_6	106370.Francci3_2857	3.799e-85	286.0	COG2229@1|root,COG2229@2|Bacteria,2GJIT@201174|Actinobacteria	201174|Actinobacteria	S	ATP- GTP-binding protein	-	-	-	ko:K06945	-	-	-	-	ko00000	-	-	-	ATP_bind_1
HKD2_k127_6508249_14	1463864.JOGO01000140_gene247	1.871e-25	109.0	COG1846@1|root,COG1846@2|Bacteria,2II46@201174|Actinobacteria	201174|Actinobacteria	K	Protein of unknown function (DUF742)	-	-	-	-	-	-	-	-	-	-	-	-	DUF742
HKD2_k127_6508249_8	656024.FsymDg_0501	5.178e-63	218.0	COG2018@1|root,COG2018@2|Bacteria,2IFTB@201174|Actinobacteria	201174|Actinobacteria	S	Roadblock/LC7 domain	-	-	-	ko:K07131	-	-	-	-	ko00000	-	-	-	Robl_LC7
HKD2_k127_6508249_0	656024.FsymDg_0502	5.141e-206	673.0	COG0642@1|root,COG0642@2|Bacteria,2GKY7@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,NIT
HKD2_k127_6508249_9	35754.JNYJ01000038_gene5033	8.849e-48	179.0	COG1309@1|root,COG1309@2|Bacteria,2GMVQ@201174|Actinobacteria,4DA7W@85008|Micromonosporales	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
HKD2_k127_6508249_2	1121272.KB903251_gene680	4.407e-145	480.0	COG0183@1|root,COG0183@2|Bacteria,2GIY0@201174|Actinobacteria,4DEW3@85008|Micromonosporales	201174|Actinobacteria	I	Thiolase, C-terminal domain	ltp1	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0003988,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005758,GO:0005777,GO:0005782,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016408,GO:0016740,GO:0016746,GO:0016747,GO:0019395,GO:0019752,GO:0030258,GO:0031907,GO:0031967,GO:0031970,GO:0031974,GO:0031975,GO:0032787,GO:0034440,GO:0042579,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044429,GO:0044438,GO:0044439,GO:0044444,GO:0044446,GO:0044464,GO:0046395,GO:0055114,GO:0070013,GO:0071704,GO:0072329,GO:0097159,GO:1901363,GO:1901575	2.3.1.16	ko:K00632	ko00071,ko00280,ko00281,ko00362,ko00592,ko00642,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00362,map00592,map00642,map01100,map01110,map01120,map01130,map01212	M00087,M00113	R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000	-	-	-	Thiolase_C,Thiolase_N
HKD2_k127_6508249_15	1464048.JNZS01000003_gene1146	1.836e-23	105.0	COG1802@1|root,COG1802@2|Bacteria,2GMI2@201174|Actinobacteria,4DM6C@85008|Micromonosporales	201174|Actinobacteria	K	FCD	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
HKD2_k127_6508249_17	1394178.AWOO02000004_gene2438	1.402e-08	57.0	COG1802@1|root,COG1802@2|Bacteria,2GMI2@201174|Actinobacteria,4EK5H@85012|Streptosporangiales	201174|Actinobacteria	K	FCD	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
HKD2_k127_6508249_1	66377.JOBH01000006_gene268	2.454e-158	505.0	COG0667@1|root,COG0667@2|Bacteria,2GJ4R@201174|Actinobacteria	201174|Actinobacteria	C	aldo keto reductase	-	-	1.1.1.65	ko:K05275	ko00750,ko01100,ko01120,map00750,map01100,map01120	-	R01708	RC00116	ko00000,ko00001,ko01000	-	-	-	Aldo_ket_red
HKD2_k127_6508249_3	479432.Sros_3625	1.99e-135	438.0	COG1063@1|root,COG1063@2|Bacteria,2GISW@201174|Actinobacteria,4EMMK@85012|Streptosporangiales	201174|Actinobacteria	E	Alcohol dehydrogenase GroES-like domain	adh	-	1.1.1.1	ko:K00001	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
HKD2_k127_6508249_11	1313172.YM304_13730	1.586e-41	156.0	COG4113@1|root,COG4113@2|Bacteria,2GR4U@201174|Actinobacteria	201174|Actinobacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	-	-	-	-	-	-	-	-	-	PIN
HKD2_k127_6508249_16	1313172.YM304_13740	7.348e-13	79.0	2DR8X@1|root,33AQM@2|Bacteria,2GXTC@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6508249_7	1894.JOER01000025_gene6921	8.61e-76	266.0	COG2146@1|root,COG2146@2|Bacteria,2I1BQ@201174|Actinobacteria	201174|Actinobacteria	P	Rieske 2Fe-2S	-	-	-	-	-	-	-	-	-	-	-	-	DUF2231,Rieske
HKD2_k127_6509809_5	656024.FsymDg_1714	2.961e-123	396.0	COG0719@1|root,COG0719@2|Bacteria,2GKCZ@201174|Actinobacteria,4ERKY@85013|Frankiales	201174|Actinobacteria	O	TIGRFAM FeS assembly protein SufB	sufB	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0034641,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:1901360	-	ko:K09014	-	-	-	-	ko00000	-	-	-	UPF0051
HKD2_k127_6509809_2	656024.FsymDg_1715	2.414e-173	563.0	COG0719@1|root,COG0719@2|Bacteria,2GJNV@201174|Actinobacteria,4ERT3@85013|Frankiales	201174|Actinobacteria	O	FeS assembly protein SufD	sufD	GO:0008150,GO:0009605,GO:0009607,GO:0040007,GO:0043207,GO:0044403,GO:0044419,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0075136	-	ko:K09015	-	-	-	-	ko00000	-	-	-	UPF0051
HKD2_k127_6509809_10	656024.FsymDg_1716	1.309e-39	159.0	COG2146@1|root,COG2146@2|Bacteria,2IQK7@201174|Actinobacteria,4ETAR@85013|Frankiales	201174|Actinobacteria	P	PFAM Rieske 2Fe-2S	hcaC	-	-	ko:K05710	ko00360,ko01120,ko01220,map00360,map01120,map01220	M00545	R06782,R06783	RC00098	br01602,ko00000,ko00001,ko00002	-	-	-	Rieske
HKD2_k127_6509809_3	1156844.KB891820_gene441	1.161e-128	422.0	COG0396@1|root,COG0396@2|Bacteria,2GKB7@201174|Actinobacteria	201174|Actinobacteria	O	FeS assembly ATPase SufC	sufC	-	-	ko:K09013	-	-	-	-	ko00000,ko02000	-	-	-	ABC_tran
HKD2_k127_6509809_1	656024.FsymDg_1718	9.041e-219	705.0	COG0520@1|root,COG0520@2|Bacteria,2GIVK@201174|Actinobacteria,4ERTT@85013|Frankiales	201174|Actinobacteria	E	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine	sufS	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	2.8.1.7,4.4.1.16	ko:K11717	ko00450,ko01100,map00450,map01100	-	R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000	-	-	-	Aminotran_5
HKD2_k127_6509809_8	656024.FsymDg_1719	2.416e-71	260.0	COG0822@1|root,COG0822@2|Bacteria,2IHY9@201174|Actinobacteria,4ESKF@85013|Frankiales	201174|Actinobacteria	C	TIGRFAM SUF system FeS assembly protein, NifU family	iscU	-	-	ko:K04488	-	-	-	-	ko00000	-	-	-	NifU_N
HKD2_k127_6509809_9	656024.FsymDg_1720	1.978e-54	201.0	COG2151@1|root,COG2151@2|Bacteria,2IKUH@201174|Actinobacteria,4ESWH@85013|Frankiales	201174|Actinobacteria	S	Pfam:DUF59	yitW	-	-	-	-	-	-	-	-	-	-	-	FeS_assembly_P
HKD2_k127_6509809_11	419947.MRA_2578	2.133e-32	138.0	COG2402@1|root,COG2402@2|Bacteria,2H9NW@201174|Actinobacteria	201174|Actinobacteria	S	toxic component of a	-	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0016787,GO:0016788,GO:0019439,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0040008,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0045926,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0065007,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575	-	ko:K07065	-	-	-	-	ko00000	-	-	-	PIN
HKD2_k127_6509809_13	1089544.KB912942_gene3670	6.177e-17	87.0	COG4636@1|root,COG4636@2|Bacteria,2IGTR@201174|Actinobacteria,4E2US@85010|Pseudonocardiales	201174|Actinobacteria	S	Putative restriction endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	Uma2
HKD2_k127_6509809_0	1056816.JAFQ01000004_gene6330	2.997e-245	788.0	COG1203@1|root,COG1203@2|Bacteria,2I266@201174|Actinobacteria	201174|Actinobacteria	L	CRISPR-associated helicase Cas3	cas3	-	-	ko:K07012	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	DEAD,Helicase_C
HKD2_k127_6509809_7	671143.DAMO_2738	1.81e-82	304.0	28JGZ@1|root,2Z9AI@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K19136	-	-	-	-	ko00000,ko02048	-	-	-	-
HKD2_k127_6509809_4	1056816.JAFQ01000004_gene6332	2.948e-127	419.0	28IJY@1|root,2Z8KS@2|Bacteria,2H4BH@201174|Actinobacteria	201174|Actinobacteria	S	CRISPR-associated protein GSU0053 (Cas_GSU0053)	-	-	-	ko:K19131	-	-	-	-	ko00000,ko02048	-	-	-	Cas_GSU0053
HKD2_k127_6509809_6	1056816.JAFQ01000004_gene6333	2.48e-114	385.0	2DBSW@1|root,2ZAU8@2|Bacteria,2GVNT@201174|Actinobacteria	201174|Actinobacteria	S	CRISPR-associated protein, GSU0054 family (Cas_GSU0054)	-	-	-	ko:K19132	-	-	-	-	ko00000,ko02048	-	-	-	-
HKD2_k127_6509809_12	1121861.KB899933_gene618	2.716e-26	110.0	COG1468@1|root,COG1518@1|root,COG1468@2|Bacteria,COG1518@2|Bacteria,1MUKK@1224|Proteobacteria,2TS91@28211|Alphaproteobacteria,2JR6F@204441|Rhodospirillales	204441|Rhodospirillales	L	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette	-	-	-	ko:K15342	-	-	-	-	ko00000,ko02048,ko03400	-	-	-	Cas_Cas1,Cas_Cas4
HKD2_k127_6516586_0	1463920.JOGB01000003_gene2715	1.383e-82	285.0	COG5285@1|root,COG5285@2|Bacteria,2GPSA@201174|Actinobacteria	201174|Actinobacteria	Q	Phytanoyl-CoA dioxygenase (PhyH)	-	-	-	ko:K15650	-	-	-	-	ko00000,ko01008	-	-	-	PhyH
HKD2_k127_6516586_1	1125971.ASJB01000031_gene1205	3.971e-69	244.0	COG3482@1|root,COG3482@2|Bacteria,2IDBJ@201174|Actinobacteria	201174|Actinobacteria	S	TfuA-like protein	-	-	-	-	-	-	-	-	-	-	-	-	TfuA
HKD2_k127_6516586_2	570268.ANBB01000061_gene945	1.446e-49	181.0	COG1944@1|root,COG1944@2|Bacteria,2I1IU@201174|Actinobacteria,4ENCC@85012|Streptosporangiales	201174|Actinobacteria	S	YcaO cyclodehydratase, ATP-ad Mg2+-binding	-	-	-	-	-	-	-	-	-	-	-	-	YcaO
HKD2_k127_6516586_3	106370.Francci3_2058	5.682e-06	48.0	COG5433@1|root,COG5433@2|Bacteria,2HYBN@201174|Actinobacteria,4EWGM@85013|Frankiales	201174|Actinobacteria	L	required for the transposition of insertion element IS2404	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_assoc
HKD2_k127_6521290_20	1206743.BAGM01000073_gene5716	2.548e-14	73.0	COG1960@1|root,COG1960@2|Bacteria,2GKQI@201174|Actinobacteria,4FUA0@85025|Nocardiaceae	201174|Actinobacteria	I	acyl-CoA dehydrogenase	fadE2_1	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HKD2_k127_6521290_19	298655.KI912266_gene4134	6.537e-21	100.0	COG0236@1|root,COG0236@2|Bacteria	2|Bacteria	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	PP-binding
HKD2_k127_6521290_9	35754.JNYJ01000026_gene8790	3.288e-118	398.0	COG0508@1|root,COG0508@2|Bacteria,2GN5J@201174|Actinobacteria,4DIEJ@85008|Micromonosporales	201174|Actinobacteria	C	e3 binding domain	-	-	2.3.1.12,2.3.1.61	ko:K00627,ko:K00658	ko00010,ko00020,ko00310,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00310,map00620,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032,M00307	R00209,R02569,R02570,R02571,R08549	RC00004,RC02727,RC02742,RC02833,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
HKD2_k127_6521290_4	1133850.SHJG_8765	3.936e-157	520.0	COG0022@1|root,COG0022@2|Bacteria,2GKFE@201174|Actinobacteria	201174|Actinobacteria	C	Pyruvate 2-oxoglutarate dehydrogenase complex dehydrogenase (E1) component eukaryotic type beta subunit	-	-	1.2.4.1	ko:K00162	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
HKD2_k127_6521290_6	1045009.AFXQ01000015_gene2484	1.322e-146	479.0	COG1071@1|root,COG1071@2|Bacteria,2IBRC@201174|Actinobacteria,1WAV4@1268|Micrococcaceae	201174|Actinobacteria	C	Dehydrogenase E1 component	pdhA	-	1.2.4.1	ko:K00161	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
HKD2_k127_6521290_0	1957.JODX01000030_gene6040	3.056e-246	775.0	COG0365@1|root,COG0365@2|Bacteria,2GNE8@201174|Actinobacteria	201174|Actinobacteria	I	synthetase	-	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
HKD2_k127_6521290_10	105420.BBPO01000008_gene2702	1.78e-112	382.0	COG0462@1|root,COG0462@2|Bacteria,2H34F@201174|Actinobacteria,2NKUV@228398|Streptacidiphilus	201174|Actinobacteria	EF	Phosphoribosyl synthetase-associated domain	-	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyl_synth,Pribosyltran,Pribosyltran_N
HKD2_k127_6521290_13	345341.KUTG_05737	1.167e-82	290.0	COG1609@1|root,COG1609@2|Bacteria,2I5VB@201174|Actinobacteria	201174|Actinobacteria	K	Periplasmic binding protein domain	-	-	-	ko:K10439	ko02010,ko02030,map02010,map02030	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	Peripla_BP_4
HKD2_k127_6521290_8	929712.KI912613_gene3765	2.425e-128	443.0	COG1129@1|root,COG1129@2|Bacteria,2GJ3F@201174|Actinobacteria,4CS7H@84995|Rubrobacteria	84995|Rubrobacteria	G	ATPases associated with a variety of cellular activities	-	-	3.6.3.17	ko:K10441	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	ABC_tran
HKD2_k127_6521290_14	1276920.ADIAG_03228	5.603e-75	282.0	COG1172@1|root,COG1172@2|Bacteria,2GMJW@201174|Actinobacteria	201174|Actinobacteria	G	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K10440	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	BPD_transp_2
HKD2_k127_6521290_1	267608.RSc1456	1.072e-187	597.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2VHQD@28216|Betaproteobacteria,1K09N@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Aldehyde dehydrogenase	betB	-	1.2.1.3,1.2.1.8	ko:K00128,ko:K00130	ko00010,ko00053,ko00071,ko00260,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00260,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135,M00555	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02565,R02566,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
HKD2_k127_6521290_15	208439.AJAP_23815	1.358e-53	196.0	COG1733@1|root,COG1733@2|Bacteria,2GMQG@201174|Actinobacteria,4E3G4@85010|Pseudonocardiales	201174|Actinobacteria	K	HxlR-like helix-turn-helix	-	-	-	-	-	-	-	-	-	-	-	-	HxlR
HKD2_k127_6521290_3	656024.FsymDg_3572	1.934e-164	530.0	COG4799@1|root,COG4799@2|Bacteria,2I16G@201174|Actinobacteria,4ERDY@85013|Frankiales	201174|Actinobacteria	I	PFAM carboxyl transferase	accD6	GO:0003674,GO:0003824,GO:0003989,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009056,GO:0009058,GO:0009062,GO:0009317,GO:0009987,GO:0016042,GO:0016053,GO:0016054,GO:0016421,GO:0016874,GO:0016885,GO:0019367,GO:0019752,GO:0030312,GO:0030497,GO:0032787,GO:0032991,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044249,GO:0044255,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046395,GO:0071704,GO:0071944,GO:0072329,GO:0072330,GO:1901575,GO:1901576,GO:1902494	2.1.3.15,6.4.1.2,6.4.1.3	ko:K18472	ko00061,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00741	R00742,R01859,R04386	RC00040,RC00097,RC00253,RC00367,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
HKD2_k127_6521290_18	2002.JOEQ01000027_gene7951	9.683e-25	120.0	COG4799@1|root,COG4799@2|Bacteria,2I16G@201174|Actinobacteria,4EGX6@85012|Streptosporangiales	201174|Actinobacteria	I	Malonate decarboxylase gamma subunit (MdcE)	accD6	GO:0003674,GO:0003824,GO:0003989,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009056,GO:0009058,GO:0009062,GO:0009317,GO:0009987,GO:0016042,GO:0016053,GO:0016054,GO:0016421,GO:0016874,GO:0016885,GO:0019367,GO:0019752,GO:0030312,GO:0030497,GO:0032787,GO:0032991,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044249,GO:0044255,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046395,GO:0071704,GO:0071944,GO:0072329,GO:0072330,GO:1901575,GO:1901576,GO:1902494	2.1.3.15,6.4.1.2,6.4.1.3	ko:K18472	ko00061,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00741	R00742,R01859,R04386	RC00040,RC00097,RC00253,RC00367,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
HKD2_k127_6521290_2	656024.FsymDg_3571	2.777e-185	603.0	COG0304@1|root,COG0304@2|Bacteria,2GIY4@201174|Actinobacteria,4ES79@85013|Frankiales	201174|Actinobacteria	I	Belongs to the beta-ketoacyl-ACP synthases family	fabF	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
HKD2_k127_6521290_16	298655.KI912267_gene7994	1.5e-38	148.0	COG0236@1|root,COG0236@2|Bacteria,2IQ43@201174|Actinobacteria,4ETBR@85013|Frankiales	201174|Actinobacteria	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	acpP	GO:0000035,GO:0000036,GO:0003674,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0006082,GO:0006139,GO:0006163,GO:0006629,GO:0006631,GO:0006633,GO:0006637,GO:0006643,GO:0006644,GO:0006664,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009117,GO:0009150,GO:0009245,GO:0009247,GO:0009259,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016053,GO:0019637,GO:0019693,GO:0019752,GO:0019842,GO:0030312,GO:0031177,GO:0032787,GO:0033218,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0035383,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044620,GO:0046394,GO:0046467,GO:0046483,GO:0046493,GO:0048037,GO:0051186,GO:0051192,GO:0055086,GO:0071704,GO:0071944,GO:0072330,GO:0072341,GO:0072521,GO:0090407,GO:0140104,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901360,GO:1901564,GO:1901576,GO:1903509	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
HKD2_k127_6521290_7	298655.KI912267_gene7993	1.383e-142	469.0	COG0332@1|root,COG0332@2|Bacteria,2GJP8@201174|Actinobacteria,4ERCI@85013|Frankiales	201174|Actinobacteria	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	fabH	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
HKD2_k127_6521290_11	298655.KI912267_gene7992	2.049e-107	361.0	COG0331@1|root,COG0331@2|Bacteria,2GME0@201174|Actinobacteria,4ERHC@85013|Frankiales	201174|Actinobacteria	I	PFAM Acyl transferase	fabD	GO:0003674,GO:0003824,GO:0004312,GO:0004314,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005835,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016417,GO:0016419,GO:0016420,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901576	2.3.1.39	ko:K00645	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	M00082	R01626,R11671	RC00004,RC00039,RC02727	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyl_transf_1
HKD2_k127_6521290_5	656024.FsymDg_3567	1.22e-149	487.0	COG2508@1|root,COG2508@2|Bacteria,2GN0S@201174|Actinobacteria,4ERDQ@85013|Frankiales	201174|Actinobacteria	QT	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_30
HKD2_k127_6521290_17	326424.FRAAL4827	9.824e-30	125.0	COG1917@1|root,COG1917@2|Bacteria	2|Bacteria	L	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HKD2_k127_6521290_12	561175.KB894093_gene2781	6.059e-99	343.0	COG0596@1|root,COG0596@2|Bacteria,2GKX3@201174|Actinobacteria	201174|Actinobacteria	S	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6521290_21	1123255.JHYS01000002_gene2460	3.819e-07	63.0	COG1942@1|root,COG1942@2|Bacteria,1N7K1@1224|Proteobacteria,2VWGR@28216|Betaproteobacteria,4AF90@80864|Comamonadaceae	28216|Betaproteobacteria	G	4-oxalocrotonate tautomerase	-	-	5.3.2.6	ko:K01821	ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00362,map00621,map00622,map01100,map01120,map01220	M00569	R03966,R05389	RC01040,RC01355	ko00000,ko00001,ko00002,ko01000	-	-	-	Tautomerase
HKD2_k127_6530471_3	882086.SacxiDRAFT_0049	3.476e-40	158.0	COG1196@1|root,COG1196@2|Bacteria,2GK6F@201174|Actinobacteria,4DYJA@85010|Pseudonocardiales	201174|Actinobacteria	D	Putative exonuclease SbcCD, C subunit	-	-	-	-	-	-	-	-	-	-	-	-	SbcCD_C
HKD2_k127_6530471_6	502025.Hoch_2803	9.784e-17	93.0	COG4924@1|root,COG4924@2|Bacteria,1QXCY@1224|Proteobacteria,4385V@68525|delta/epsilon subdivisions,2X3FP@28221|Deltaproteobacteria,2YVWJ@29|Myxococcales	28221|Deltaproteobacteria	S	Protein of unknown function C-terminus (DUF2399)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2399,DUF3323
HKD2_k127_6530471_8	1298880.AUEV01000017_gene1058	1.728e-07	54.0	COG4924@1|root,COG4924@2|Bacteria,2GNHY@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function N-terminus (DUF3323)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2399,DUF3323
HKD2_k127_6530471_7	1286631.X805_14960	1.147e-07	57.0	COG4924@1|root,COG4924@2|Bacteria,1QXCY@1224|Proteobacteria,2VJDH@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Protein of unknown function N-terminus (DUF3323)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2399,DUF3323
HKD2_k127_6530471_4	479432.Sros_2013	1.774e-31	130.0	COG2402@1|root,COG2402@2|Bacteria,2IRQ5@201174|Actinobacteria	201174|Actinobacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	ko:K07065	-	-	-	-	ko00000	-	-	-	PIN
HKD2_k127_6530471_5	106370.Francci3_0391	2.346e-28	119.0	COG3385@1|root,COG3385@2|Bacteria,2ICCW@201174|Actinobacteria	201174|Actinobacteria	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5,DDE_Tnp_1
HKD2_k127_6530471_2	1122611.KB903998_gene8215	7.483e-115	380.0	COG0182@1|root,COG0182@2|Bacteria,2GJJA@201174|Actinobacteria,4EINP@85012|Streptosporangiales	201174|Actinobacteria	J	Initiation factor 2 subunit family	mtnA	-	5.3.1.23	ko:K08963	ko00270,ko01100,map00270,map01100	M00034	R04420	RC01151	ko00000,ko00001,ko00002,ko01000	-	-	-	IF-2B
HKD2_k127_6530471_0	1123322.KB904658_gene1286	3.312e-253	797.0	COG1028@1|root,COG3347@1|root,COG1028@2|Bacteria,COG3347@2|Bacteria,2GNEI@201174|Actinobacteria	201174|Actinobacteria	IQ	Rhamnulose-1-phosphate aldolase alcohol dehydrogenase	srlD	-	1.1.1.140	ko:K00068	ko00051,map00051	-	R05607	RC00085	ko00000,ko00001,ko01000	-	-	-	Aldolase_II,adh_short,adh_short_C2
HKD2_k127_6530471_1	864702.OsccyDRAFT_3484	2.274e-120	401.0	COG3266@1|root,COG3391@1|root,COG3266@2|Bacteria,COG3391@2|Bacteria,1G33X@1117|Cyanobacteria,1H9RN@1150|Oscillatoriales	1117|Cyanobacteria	M	Putative peptidoglycan binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_D1,PG_binding_1
HKD2_k127_6538077_4	222534.KB893715_gene1693	1.206e-05	47.0	COG5421@1|root,COG5421@2|Bacteria,2GK2A@201174|Actinobacteria	201174|Actinobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
HKD2_k127_6538077_3	566461.SSFG_02378	6.432e-10	70.0	COG0457@1|root,COG0457@2|Bacteria,2GJSG@201174|Actinobacteria	201174|Actinobacteria	K	viral genome integration into host DNA	-	-	-	-	-	-	-	-	-	-	-	-	HTH_31
HKD2_k127_6538077_0	1380393.JHVP01000002_gene1888	4.864e-103	352.0	COG0308@1|root,COG0308@2|Bacteria,2IAPJ@201174|Actinobacteria	201174|Actinobacteria	E	Peptidase family M1 domain	-	-	-	-	-	-	-	-	-	-	-	-	He_PIG,Peptidase_M1,Peptidase_M6
HKD2_k127_6538077_1	1122611.KB903958_gene4086	2.503e-63	226.0	COG2030@1|root,COG2030@2|Bacteria,2IFCJ@201174|Actinobacteria,4EIIF@85012|Streptosporangiales	201174|Actinobacteria	I	MaoC like domain	hadB	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydrat_N,MaoC_dehydratas
HKD2_k127_6538077_2	656024.FsymDg_3980	1.144e-34	135.0	COG2030@1|root,COG2030@2|Bacteria,2GMVC@201174|Actinobacteria	201174|Actinobacteria	I	Belongs to the UPF0336 family	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydrat_N
HKD2_k127_6538478_10	525909.Afer_0055	6.681e-09	61.0	2DMWY@1|root,32U6G@2|Bacteria,2ISFN@201174|Actinobacteria,4CNVD@84992|Acidimicrobiia	84992|Acidimicrobiia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6538478_9	1464048.JNZS01000020_gene2129	5.094e-09	67.0	COG1813@1|root,COG1813@2|Bacteria,2HWQX@201174|Actinobacteria,4DK0X@85008|Micromonosporales	201174|Actinobacteria	K	sequence-specific DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6538478_4	656024.FsymDg_3047	1.973e-120	394.0	2E0J4@1|root,32W4R@2|Bacteria,2GS2T@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6538478_2	211114.JOEF01000001_gene7178	3.755e-125	431.0	COG4188@1|root,COG4188@2|Bacteria,2I3KQ@201174|Actinobacteria,4DZZ4@85010|Pseudonocardiales	201174|Actinobacteria	S	dienelactone hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_5,Calx-beta,Chlorophyllase2
HKD2_k127_6538478_14	933262.AXAM01000204_gene1274	0.0002171	48.0	COG1895@1|root,COG1895@2|Bacteria,1Q7Y6@1224|Proteobacteria,433AB@68525|delta/epsilon subdivisions,2WYB2@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	HEPN domain	-	-	-	-	-	-	-	-	-	-	-	-	HEPN
HKD2_k127_6538478_11	29306.JOBE01000096_gene2410	1.187e-08	58.0	COG5659@1|root,COG5659@2|Bacteria,2GIU9@201174|Actinobacteria	201174|Actinobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5
HKD2_k127_6538478_0	365528.KB891263_gene642	0.0	1537.0	COG0587@1|root,COG0587@2|Bacteria,2GJ1P@201174|Actinobacteria,4ERD2@85013|Frankiales	201174|Actinobacteria	L	DNA polymerase III alpha subunit	dnaE	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
HKD2_k127_6538478_7	1078020.KEK_00740	8.033e-39	165.0	COG0140@1|root,COG0140@2|Bacteria,2H25S@201174|Actinobacteria,238C3@1762|Mycobacteriaceae	201174|Actinobacteria	E	phosphoribosyl-ATP diphosphatase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6538478_5	298654.FraEuI1c_0065	1.36e-82	301.0	COG0454@1|root,COG2153@1|root,COG0456@2|Bacteria,COG2153@2|Bacteria	2|Bacteria	K	protein acetylation	yjcF	GO:0003674,GO:0003824,GO:0016740,GO:0016746,GO:0016747	-	ko:K02348,ko:K03828	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_10
HKD2_k127_6538478_1	656024.FsymDg_3064	5.298e-140	460.0	COG0564@1|root,COG2302@1|root,COG0564@2|Bacteria,COG2302@2|Bacteria,2GIY1@201174|Actinobacteria,4ERPM@85013|Frankiales	201174|Actinobacteria	J	Responsible for synthesis of pseudouridine from uracil	rluD	GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
HKD2_k127_6538478_6	365528.KB891102_gene4404	7.606e-62	218.0	COG0597@1|root,COG0597@2|Bacteria,2GKRX@201174|Actinobacteria,4ET0T@85013|Frankiales	201174|Actinobacteria	MU	This protein specifically catalyzes the removal of signal peptides from prolipoproteins	lspA	GO:0006464,GO:0006497,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009405,GO:0009987,GO:0019538,GO:0034645,GO:0036211,GO:0040007,GO:0042157,GO:0042158,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044419,GO:0051704,GO:0071704,GO:1901564,GO:1901566,GO:1901576	3.4.23.36	ko:K03101	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_A8
HKD2_k127_6538478_8	561175.KB894098_gene5384	3.14e-17	82.0	COG1734@1|root,COG1734@2|Bacteria,2GJBE@201174|Actinobacteria,4EJJN@85012|Streptosporangiales	201174|Actinobacteria	T	Prokaryotic dksA/traR C4-type zinc finger	-	-	-	ko:K06204	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000,ko03009,ko03021	-	-	-	zf-dskA_traR
HKD2_k127_6538478_13	266940.Krad_3190	4.342e-05	49.0	COG1734@1|root,COG1734@2|Bacteria,2GJBE@201174|Actinobacteria	201174|Actinobacteria	T	Transcriptional regulator, TraR DksA family	-	-	-	ko:K06204	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000,ko03009,ko03021	-	-	-	zf-dskA_traR
HKD2_k127_6538478_3	656024.FsymDg_3066	6.475e-122	398.0	COG0060@1|root,COG0060@2|Bacteria,2GK9M@201174|Actinobacteria,4ERW9@85013|Frankiales	201174|Actinobacteria	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	GO:0003674,GO:0003824,GO:0004812,GO:0004822,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006428,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
HKD2_k127_655831_4	357808.RoseRS_4348	4.255e-179	569.0	COG0183@1|root,COG0183@2|Bacteria,2GAQ4@200795|Chloroflexi,3770V@32061|Chloroflexia	32061|Chloroflexia	I	Belongs to the thiolase family	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
HKD2_k127_655831_2	1268237.G114_09975	6.111e-194	636.0	COG2079@1|root,COG2079@2|Bacteria,1MUIG@1224|Proteobacteria,1RPQN@1236|Gammaproteobacteria,1Y5JH@135624|Aeromonadales	135624|Aeromonadales	S	2-methylcitrate dehydratase	prpD	-	4.2.1.79	ko:K01720	ko00640,map00640	-	R04424	RC01152	ko00000,ko00001,ko01000	-	-	-	MmgE_PrpD
HKD2_k127_655831_8	266117.Rxyl_2401	1.815e-127	418.0	COG0372@1|root,COG0372@2|Bacteria,2GJ7E@201174|Actinobacteria,4CPID@84995|Rubrobacteria	201174|Actinobacteria	C	Belongs to the citrate synthase family	prpC	GO:0003674,GO:0003824,GO:0006082,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009987,GO:0016740,GO:0016746,GO:0016999,GO:0017144,GO:0019541,GO:0019679,GO:0019752,GO:0032787,GO:0036440,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0046459,GO:0046912,GO:0050440,GO:0071704	2.3.3.1,2.3.3.5	ko:K01647,ko:K01659	ko00020,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00640,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351,R00931	RC00004,RC00067,RC00406,RC02827	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
HKD2_k127_655831_9	349124.Hhal_1072	2.418e-114	378.0	COG2513@1|root,COG2513@2|Bacteria,1N4VT@1224|Proteobacteria,1RMR5@1236|Gammaproteobacteria,1WWC7@135613|Chromatiales	135613|Chromatiales	G	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate	prpB	-	4.1.3.30	ko:K03417	ko00640,map00640	-	R00409	RC00286,RC00287	ko00000,ko00001,ko01000	-	-	-	PEP_mutase
HKD2_k127_655831_11	882082.SaccyDRAFT_2706	1.516e-90	310.0	COG0623@1|root,COG0623@2|Bacteria,2GJ65@201174|Actinobacteria,4DZIM@85010|Pseudonocardiales	201174|Actinobacteria	I	Enoyl- acyl-carrier-protein reductase NADH	fabI	-	1.3.1.10,1.3.1.9	ko:K00208	ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212	M00083,M00572	R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671	RC00052,RC00076,RC00120	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HKD2_k127_655831_10	656024.FsymDg_0769	3.716e-93	315.0	COG2021@1|root,COG2021@2|Bacteria,2I3NA@201174|Actinobacteria,4EXFB@85013|Frankiales	201174|Actinobacteria	E	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Hydrolase_4
HKD2_k127_655831_0	326424.FRAAL6215	9.103e-317	1006.0	COG4867@1|root,COG4867@2|Bacteria,2H14W@201174|Actinobacteria,4ERSP@85013|Frankiales	201174|Actinobacteria	S	von Willebrand factor type A	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	VWA_2
HKD2_k127_655831_1	298654.FraEuI1c_0666	3.725e-240	795.0	COG1239@1|root,COG1239@2|Bacteria,2GMRS@201174|Actinobacteria,4ES5K@85013|Frankiales	201174|Actinobacteria	H	Mg-chelatase subunit ChlI	chlI	-	6.6.1.1	ko:K03405	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R03877	RC01012	ko00000,ko00001,ko01000	-	-	iNJ661.Rv0958	Mg_chelatase,Sigma54_activat
HKD2_k127_655831_14	1278073.MYSTI_00135	3.617e-31	135.0	COG0596@1|root,COG0596@2|Bacteria,1QQUJ@1224|Proteobacteria,43CMT@68525|delta/epsilon subdivisions,2X7UY@28221|Deltaproteobacteria,2Z2EV@29|Myxococcales	28221|Deltaproteobacteria	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
HKD2_k127_655831_13	526225.Gobs_0407	4.118e-62	229.0	COG0438@1|root,COG1215@1|root,COG0438@2|Bacteria,COG1215@2|Bacteria,2GNIU@201174|Actinobacteria	201174|Actinobacteria	M	Glycosyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1,Glycos_transf_2
HKD2_k127_655831_7	1120950.KB892763_gene5543	6.694e-128	423.0	COG2124@1|root,COG2124@2|Bacteria,2GK4Z@201174|Actinobacteria,4DR6Y@85009|Propionibacteriales	201174|Actinobacteria	C	Cytochrome P450	-	-	-	-	-	-	-	-	-	-	-	-	p450
HKD2_k127_655831_5	526225.Gobs_0935	1.416e-157	509.0	COG1171@1|root,COG1171@2|Bacteria,2GJAG@201174|Actinobacteria,4ES0N@85013|Frankiales	201174|Actinobacteria	E	PFAM Pyridoxal-5'-phosphate-dependent protein beta subunit	ilvA	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,PALP
HKD2_k127_655831_3	44060.JODL01000030_gene969	6.893e-189	594.0	COG3185@1|root,COG3185@2|Bacteria,2GNF0@201174|Actinobacteria	201174|Actinobacteria	E	4-hydroxyphenylpyruvate dioxygenase	hpd	GO:0003674,GO:0003824,GO:0003868,GO:0006082,GO:0006520,GO:0006570,GO:0006572,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009072,GO:0009074,GO:0009987,GO:0016054,GO:0016491,GO:0016701,GO:0016702,GO:0019439,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0051213,GO:0055114,GO:0071704,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	1.13.11.27	ko:K00457	ko00130,ko00350,ko00360,ko01100,map00130,map00350,map00360,map01100	M00044	R01372,R02521	RC00505,RC00738	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Glyoxalase
HKD2_k127_655831_12	656024.FsymDg_0773	3.347e-72	246.0	COG0782@1|root,COG0782@2|Bacteria,2GNZV@201174|Actinobacteria,4ESVY@85013|Frankiales	201174|Actinobacteria	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides	greA	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0050896,GO:0071944	-	ko:K03624	-	-	-	-	ko00000,ko03021	-	-	-	GreA_GreB,GreA_GreB_N
HKD2_k127_655831_6	298653.Franean1_0826	1.515e-147	476.0	COG2120@1|root,COG2120@2|Bacteria,2H2NY@201174|Actinobacteria,4ERKF@85013|Frankiales	201174|Actinobacteria	S	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics	mca	GO:0003674,GO:0005488,GO:0006790,GO:0008150,GO:0008152,GO:0008270,GO:0009636,GO:0009987,GO:0010126,GO:0010127,GO:0016137,GO:0042221,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914,GO:0050896,GO:0051186,GO:0071704,GO:0098754,GO:1901135,GO:1901657	3.5.1.115	ko:K18455	-	-	-	-	ko00000,ko01000	-	-	-	PIG-L
HKD2_k127_655831_15	298653.Franean1_1940	1.015e-13	76.0	COG3793@1|root,COG3793@2|Bacteria,2HANB@201174|Actinobacteria,4EVR4@85013|Frankiales	201174|Actinobacteria	P	PFAM Tellurite resistance	terB	-	-	ko:K05793	-	-	-	-	ko00000	-	-	-	TerB
HKD2_k127_6610641_9	1380390.JIAT01000014_gene6273	4.145e-67	244.0	COG2267@1|root,COG2267@2|Bacteria,2HFRI@201174|Actinobacteria,4CQZ8@84995|Rubrobacteria	84995|Rubrobacteria	I	SCP-2 sterol transfer family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,SCP2
HKD2_k127_6610641_0	208444.JNYY01000013_gene7593	0.0	1219.0	COG3387@1|root,COG4945@1|root,COG3387@2|Bacteria,COG4945@2|Bacteria,2HCB8@201174|Actinobacteria,4E21Z@85010|Pseudonocardiales	201174|Actinobacteria	G	Glucodextranase, domain N	-	-	3.2.1.3	ko:K01178	ko00500,ko01100,map00500,map01100	-	R01790,R01791,R06199	-	ko00000,ko00001,ko01000	-	GH15	-	Glucodextran_C,Glucodextran_N,Glyco_hydro_15
HKD2_k127_6610641_5	1869.MB27_10265	1.391e-92	322.0	COG0667@1|root,COG0667@2|Bacteria,2GJWD@201174|Actinobacteria,4DH3F@85008|Micromonosporales	201174|Actinobacteria	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
HKD2_k127_6610641_3	644283.Micau_3943	1.768e-117	427.0	COG1009@1|root,COG3002@1|root,COG1009@2|Bacteria,COG3002@2|Bacteria,2ID5K@201174|Actinobacteria,4DICJ@85008|Micromonosporales	201174|Actinobacteria	CP	Uncharacterized protein conserved in bacteria (DUF2309)	-	-	-	ko:K09822	-	-	-	-	ko00000	-	-	-	DUF2309,Proton_antipo_M
HKD2_k127_6610641_2	1265313.HRUBRA_02418	3.913e-119	398.0	COG3002@1|root,COG3002@2|Bacteria,1MX5K@1224|Proteobacteria,1RQC2@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Belongs to the UPF0753 family	-	-	-	ko:K09822	-	-	-	-	ko00000	-	-	-	DUF2309
HKD2_k127_6610641_11	1440774.Y900_023155	2.534e-35	139.0	COG3002@1|root,COG3002@2|Bacteria,2ID5K@201174|Actinobacteria,234FN@1762|Mycobacteriaceae	201174|Actinobacteria	S	Belongs to the UPF0753 family	-	-	-	ko:K09822	-	-	-	-	ko00000	-	-	-	DUF2309,Proton_antipo_M
HKD2_k127_6610641_12	35754.JNYJ01000018_gene9604	6.012e-30	140.0	COG0347@1|root,COG0347@2|Bacteria,2IN02@201174|Actinobacteria,4DJWZ@85008|Micromonosporales	201174|Actinobacteria	K	Uncharacterized ACR, COG1993	-	-	-	-	-	-	-	-	-	-	-	-	DUF190
HKD2_k127_6610641_6	656024.FsymDg_1185	1.64e-84	287.0	COG0378@1|root,COG0378@2|Bacteria,2GNUV@201174|Actinobacteria,4EUGN@85013|Frankiales	201174|Actinobacteria	KO	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG	ureG	GO:0003674,GO:0003824,GO:0003924,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111	-	ko:K03189	-	-	-	-	ko00000	-	-	-	cobW
HKD2_k127_6610641_1	1996.JOFO01000018_gene5381	6.424e-134	433.0	COG2141@1|root,COG2141@2|Bacteria,2GM94@201174|Actinobacteria,4EG02@85012|Streptosporangiales	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
HKD2_k127_6610641_7	656024.FsymDg_1805	7.006e-82	276.0	COG0663@1|root,COG0663@2|Bacteria,2GP22@201174|Actinobacteria,4EVCG@85013|Frankiales	201174|Actinobacteria	S	Bacterial transferase hexapeptide (six repeats)	gca	-	-	ko:K02617	-	-	-	-	ko00000	-	-	-	Hexapep
HKD2_k127_6610641_13	378806.STAUR_7978	6.582e-05	50.0	2CAZG@1|root,30VUZ@2|Bacteria,1PPP8@1224|Proteobacteria,435CM@68525|delta/epsilon subdivisions,2WZQ7@28221|Deltaproteobacteria,2Z2I0@29|Myxococcales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF4276)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4276
HKD2_k127_6610641_10	983917.RGE_06130	9.729e-49	190.0	COG4637@1|root,COG4637@2|Bacteria,1ND40@1224|Proteobacteria,2VHTI@28216|Betaproteobacteria,1KPB5@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	AAA ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_15,AAA_21
HKD2_k127_6610641_4	710111.FraQA3DRAFT_2978	3.316e-112	368.0	COG0483@1|root,COG0483@2|Bacteria,2GJQE@201174|Actinobacteria,4ESCZ@85013|Frankiales	201174|Actinobacteria	G	Inositol monophosphatase	suhB	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005975,GO:0006020,GO:0006066,GO:0006793,GO:0006796,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0008934,GO:0009056,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019637,GO:0019751,GO:0023052,GO:0042578,GO:0043167,GO:0043169,GO:0043647,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0046164,GO:0046174,GO:0046434,GO:0046838,GO:0046855,GO:0046872,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0052745,GO:0052834,GO:0065007,GO:0071545,GO:0071704,GO:1901575,GO:1901615,GO:1901616	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
HKD2_k127_6610641_8	106370.Francci3_1312	2.113e-74	252.0	COG1048@1|root,COG1048@2|Bacteria,2GJD5@201174|Actinobacteria,4ESAU@85013|Frankiales	201174|Actinobacteria	C	Aconitate hydratase 1	acnA	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
HKD2_k127_6612320_2	710111.FraQA3DRAFT_4316	3.64e-114	369.0	COG0353@1|root,COG0353@2|Bacteria,2GJY0@201174|Actinobacteria,4ES6F@85013|Frankiales	201174|Actinobacteria	L	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO	recR	-	-	ko:K06187	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	HHH,RecR,Toprim_4
HKD2_k127_6612320_3	266117.Rxyl_1997	6.429e-57	212.0	COG0454@1|root,COG0456@2|Bacteria,2I4BM@201174|Actinobacteria,4CQBU@84995|Rubrobacteria	84995|Rubrobacteria	K	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HKD2_k127_6612320_5	710111.FraQA3DRAFT_4318	8.512e-45	173.0	2FCKD@1|root,344PQ@2|Bacteria,2GVQX@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6612320_4	1089544.KB912942_gene6593	9.504e-50	199.0	COG0412@1|root,COG0412@2|Bacteria,2GNWB@201174|Actinobacteria,4DZTQ@85010|Pseudonocardiales	201174|Actinobacteria	Q	Dienelactone hydrolase family	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
HKD2_k127_6612320_0	710111.FraQA3DRAFT_4321	2.029e-221	698.0	COG0527@1|root,COG0527@2|Bacteria,2GN0G@201174|Actinobacteria,4ERII@85013|Frankiales	201174|Actinobacteria	E	Belongs to the aspartokinase family	ask	GO:0003674,GO:0003824,GO:0004072,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006520,GO:0006553,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016020,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019202,GO:0019752,GO:0019877,GO:0030312,GO:0040007,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046451,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT,ACT_7
HKD2_k127_6612320_1	222534.KB893750_gene4284	4.514e-187	589.0	COG0136@1|root,COG0136@2|Bacteria,2GJJ8@201174|Actinobacteria,4ERE4@85013|Frankiales	201174|Actinobacteria	E	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate	asd	-	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
HKD2_k127_6612320_6	298655.KI912266_gene2336	5.782e-32	125.0	COG1278@1|root,COG1278@2|Bacteria,2GQRU@201174|Actinobacteria	201174|Actinobacteria	K	Cold shock protein	-	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
HKD2_k127_6617432_2	469383.Cwoe_3429	1.322e-16	80.0	COG1295@1|root,COG1295@2|Bacteria	2|Bacteria	S	lipopolysaccharide transmembrane transporter activity	-	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Virul_fac_BrkB
HKD2_k127_6617432_1	479433.Caci_5288	5.334e-61	222.0	COG1295@1|root,COG1295@2|Bacteria	2|Bacteria	S	lipopolysaccharide transmembrane transporter activity	-	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Virul_fac_BrkB
HKD2_k127_6617432_0	1463879.JOHP01000015_gene4482	1.862e-126	434.0	COG0477@1|root,COG2814@2|Bacteria,2I8TX@201174|Actinobacteria	201174|Actinobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD2_k127_6626134_7	452652.KSE_39600	3.552e-46	190.0	COG4934@1|root,COG4934@2|Bacteria,2GMZ8@201174|Actinobacteria,2M1RS@2063|Kitasatospora	201174|Actinobacteria	O	Pro-kumamolisin, activation domain	-	-	-	ko:K08677	-	-	-	-	ko00000,ko01002	-	-	-	He_PIG,Pro-kuma_activ
HKD2_k127_6626134_2	298654.FraEuI1c_2205	7.371e-155	494.0	COG1159@1|root,COG1159@2|Bacteria,2GJJE@201174|Actinobacteria,4ERS4@85013|Frankiales	201174|Actinobacteria	S	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism	era	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464	-	ko:K03595	-	-	-	-	ko00000,ko03009,ko03029	-	-	-	KH_2,MMR_HSR1
HKD2_k127_6626134_10	1906.SFRA_16770	2.943e-14	76.0	COG3462@1|root,COG3462@2|Bacteria,2GRGM@201174|Actinobacteria	201174|Actinobacteria	S	membrane protein (DUF2078)	-	-	-	ko:K08982	-	-	-	-	ko00000	-	-	-	SHOCT
HKD2_k127_6626134_5	981369.JQMJ01000003_gene7139	1.42e-55	199.0	COG1051@1|root,COG1051@2|Bacteria,2INEY@201174|Actinobacteria,2NMPD@228398|Streptacidiphilus	201174|Actinobacteria	F	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
HKD2_k127_6626134_6	479433.Caci_8549	3.288e-52	189.0	COG1813@1|root,COG1813@2|Bacteria,2I39C@201174|Actinobacteria	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_31
HKD2_k127_6626134_3	1172180.KB911775_gene6246	3.527e-89	302.0	COG0705@1|root,COG0705@2|Bacteria,2GNPK@201174|Actinobacteria	201174|Actinobacteria	S	PFAM Rhomboid family protein	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
HKD2_k127_6626134_8	298655.KI912266_gene5313	5.579e-36	150.0	COG0295@1|root,COG0295@2|Bacteria,2IM42@201174|Actinobacteria,4ETET@85013|Frankiales	201174|Actinobacteria	F	cytidine deaminase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6626134_0	656024.FsymDg_1622	6.737e-182	584.0	COG1253@1|root,COG1253@2|Bacteria,2GIWR@201174|Actinobacteria,4ERRK@85013|Frankiales	201174|Actinobacteria	S	CBS domain containing protein	corC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
HKD2_k127_6626134_4	656024.FsymDg_1621	6.471e-62	218.0	COG0319@1|root,COG0319@2|Bacteria,2GMUF@201174|Actinobacteria,4ESS6@85013|Frankiales	201174|Actinobacteria	J	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA	ybeY	-	-	ko:K07042	-	-	-	-	ko00000,ko03009	-	-	-	UPF0054
HKD2_k127_6626134_1	298655.KI912266_gene5316	3.362e-169	538.0	COG1702@1|root,COG1702@2|Bacteria,2GK0W@201174|Actinobacteria,4ERQ7@85013|Frankiales	201174|Actinobacteria	T	PFAM PhoH family protein	phoH	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K06217	-	-	-	-	ko00000	-	-	-	PhoH
HKD2_k127_6626134_9	1906.SFRA_02105	1.645e-26	111.0	COG1385@1|root,COG1385@2|Bacteria,2GTKX@201174|Actinobacteria	201174|Actinobacteria	J	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit	rsmE	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016436,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070042,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.193	ko:K09761	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_RNA
HKD2_k127_6656077_2	391037.Sare_3675	8.57e-77	276.0	COG0631@1|root,COG0631@2|Bacteria,2GMVJ@201174|Actinobacteria	201174|Actinobacteria	T	protein serine/threonine phosphatase activity	-	-	-	-	-	-	-	-	-	-	-	-	PP2C_2
HKD2_k127_6656077_3	408672.NBCG_00594	1.321e-61	222.0	COG1595@1|root,COG1595@2|Bacteria,2I8WG@201174|Actinobacteria	201174|Actinobacteria	K	DNA-templated transcription, initiation	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r4
HKD2_k127_6656077_1	471852.Tcur_4061	2.987e-130	427.0	COG1737@1|root,COG1737@2|Bacteria,2GMG0@201174|Actinobacteria,4EG56@85012|Streptosporangiales	201174|Actinobacteria	K	Bacterial phospho-glucose isomerase C-terminal SIS domain	-	-	5.3.1.8,5.3.1.9	ko:K15916	ko00010,ko00030,ko00051,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00500,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114	R01819,R02739,R02740,R03321	RC00376,RC00563	ko00000,ko00001,ko00002,ko01000	-	-	-	bact-PGI_C
HKD2_k127_6656077_5	656024.FsymDg_1092	1.857e-18	86.0	COG2835@1|root,COG2835@2|Bacteria,2HUT6@201174|Actinobacteria,4ETHY@85013|Frankiales	201174|Actinobacteria	S	Trm112p-like protein	-	-	-	ko:K09791	-	-	-	-	ko00000	-	-	-	Trm112p
HKD2_k127_6656077_0	656024.FsymDg_1091	5.594e-220	689.0	COG1109@1|root,COG1109@2|Bacteria,2GJQA@201174|Actinobacteria,4ERK1@85013|Frankiales	201174|Actinobacteria	G	phosphoglucomutase phosphomannomutase alpha beta alpha domain I	manB	GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0004614,GO:0004615,GO:0005488,GO:0005975,GO:0005976,GO:0006082,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009243,GO:0009244,GO:0009311,GO:0009312,GO:0009405,GO:0009987,GO:0016051,GO:0016053,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0019752,GO:0033692,GO:0034637,GO:0034645,GO:0042120,GO:0042121,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044281,GO:0044283,GO:0044419,GO:0046394,GO:0046401,GO:0046402,GO:0046872,GO:0051704,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	5.4.2.8	ko:K01840	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114	R01818	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
HKD2_k127_6656077_4	326424.FRAAL1270	2.724e-34	133.0	2C7XW@1|root,32RR4@2|Bacteria,2IQ5R@201174|Actinobacteria,4ET3W@85013|Frankiales	201174|Actinobacteria	S	Protein of unknown function (DUF3499)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3499
HKD2_k127_6676713_1	656024.FsymDg_1527	5e-324	1006.0	COG0768@1|root,COG0768@2|Bacteria,2GJ61@201174|Actinobacteria,4ESAY@85013|Frankiales	201174|Actinobacteria	M	Penicillin-binding protein, dimerisation domain	mrdA	-	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	-	FTSW_RODA_SPOVE,PBP_dimer,Transpeptidase
HKD2_k127_6676713_7	365528.KB891102_gene4583	4.455e-35	147.0	COG2891@1|root,COG2891@2|Bacteria,2GN0I@201174|Actinobacteria,4EWK3@85013|Frankiales	201174|Actinobacteria	M	rod shape-determining protein MreD	mreD	-	-	ko:K03571	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreD
HKD2_k127_6676713_5	298655.KI912266_gene5501	7.544e-107	355.0	COG1792@1|root,COG1792@2|Bacteria,2GJN0@201174|Actinobacteria,4ET4T@85013|Frankiales	201174|Actinobacteria	M	Involved in formation and maintenance of cell shape	mreC	-	-	ko:K03570	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreC
HKD2_k127_6676713_2	656024.FsymDg_1524	5.16e-205	640.0	COG1077@1|root,COG1077@2|Bacteria,2GMD1@201174|Actinobacteria,4ES3S@85013|Frankiales	201174|Actinobacteria	D	TIGRFAM Cell shape determining protein MreB Mrl	mreB	-	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
HKD2_k127_6676713_6	710111.FraQA3DRAFT_3120	8.799e-67	232.0	COG0105@1|root,COG0105@2|Bacteria,2IFBU@201174|Actinobacteria,4ESUM@85013|Frankiales	201174|Actinobacteria	F	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate	ndk	GO:0003674,GO:0003824,GO:0004518,GO:0004550,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006165,GO:0006220,GO:0006464,GO:0006468,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009132,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0016787,GO:0016788,GO:0018995,GO:0019205,GO:0019538,GO:0019637,GO:0033643,GO:0033646,GO:0033647,GO:0033648,GO:0034641,GO:0036211,GO:0042025,GO:0043170,GO:0043412,GO:0043656,GO:0043657,GO:0044215,GO:0044216,GO:0044217,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044281,GO:0044464,GO:0046483,GO:0046777,GO:0046939,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072527,GO:0090304,GO:0090305,GO:1901360,GO:1901564	2.7.4.6	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	M00049,M00050,M00052,M00053	R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895	RC00002	ko00000,ko00001,ko00002,ko01000,ko04131	-	-	iNJ661.Rv2445c	NDK
HKD2_k127_6676713_9	1394178.AWOO02000035_gene8990	1.478e-07	64.0	COG0477@1|root,COG0477@2|Bacteria,2ID6G@201174|Actinobacteria,4EHPI@85012|Streptosporangiales	201174|Actinobacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6676713_3	656024.FsymDg_1522	3.476e-204	647.0	COG0285@1|root,COG0285@2|Bacteria,2GJP2@201174|Actinobacteria,4ERQF@85013|Frankiales	201174|Actinobacteria	H	Mur ligase, middle domain protein	folC	GO:0003674,GO:0003824,GO:0004326,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006761,GO:0006807,GO:0008150,GO:0008152,GO:0008841,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046452,GO:0046483,GO:0046900,GO:0046901,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.2.12,6.3.2.17	ko:K11754	ko00790,ko01100,map00790,map01100	M00126,M00841	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv2447c	Mur_ligase_C,Mur_ligase_M
HKD2_k127_6676713_0	67257.JODR01000023_gene5263	0.0	1199.0	COG0525@1|root,COG0525@2|Bacteria,2GK8H@201174|Actinobacteria	201174|Actinobacteria	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0030312,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
HKD2_k127_6676713_8	469383.Cwoe_3353	5.685e-32	135.0	2BN7C@1|root,32GUQ@2|Bacteria,2HRTT@201174|Actinobacteria,4CTX6@84995|Rubrobacteria	84995|Rubrobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6676713_4	106370.Francci3_1207	4.193e-178	559.0	COG1219@1|root,COG1219@2|Bacteria,2GJXQ@201174|Actinobacteria,4ERKD@85013|Frankiales	201174|Actinobacteria	O	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP	clpX	GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030163,GO:0030312,GO:0030554,GO:0031333,GO:0032271,GO:0032272,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0043254,GO:0044087,GO:0044238,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051301,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575	-	ko:K03544	ko04112,map04112	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA_2,ClpB_D2-small,zf-C4_ClpX
HKD2_k127_6742997_5	1380390.JIAT01000009_gene1628	1.199e-30	141.0	COG2909@1|root,COG2909@2|Bacteria,2GJAR@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GerE
HKD2_k127_6742997_2	1380347.JNII01000006_gene1628	6.085e-106	375.0	COG2909@1|root,COG2909@2|Bacteria,2GJAR@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GerE
HKD2_k127_6742997_1	1380390.JIAT01000009_gene1072	3.43e-122	423.0	COG0477@1|root,COG0477@2|Bacteria,2I31V@201174|Actinobacteria,4CPF3@84995|Rubrobacteria	84995|Rubrobacteria	EGP	PFAM major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD2_k127_6742997_3	67373.JOBF01000016_gene4929	6.477e-71	245.0	COG0454@1|root,COG0456@2|Bacteria,2IAC7@201174|Actinobacteria	201174|Actinobacteria	K	Aminoglycoside 2'-N-acetyltransferase	aac	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008080,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016020,GO:0016137,GO:0016139,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0016999,GO:0017001,GO:0017144,GO:0030647,GO:0030649,GO:0034069,GO:0044237,GO:0044248,GO:0044464,GO:0047921,GO:0071704,GO:0071944,GO:1901135,GO:1901136,GO:1901575,GO:1901657,GO:1901658	2.3.1.59	ko:K17840	-	-	-	-	br01600,ko00000,ko01000,ko01504	-	-	-	Acetyltransf_1,Acetyltransf_9
HKD2_k127_6742997_4	1283283.ATXA01000002_gene2761	1.956e-61	217.0	COG0288@1|root,COG0288@2|Bacteria,2GM1M@201174|Actinobacteria,4EVP8@85013|Frankiales	201174|Actinobacteria	P	Carbonic anhydrase	cah	-	4.2.1.1	ko:K01673	ko00910,map00910	-	R00132,R10092	RC02807	ko00000,ko00001,ko01000	-	-	-	Pro_CA
HKD2_k127_6742997_0	101510.RHA1_ro00864	5.424e-188	615.0	COG1835@1|root,COG1835@2|Bacteria,2GKI5@201174|Actinobacteria,4FWUN@85025|Nocardiaceae	201174|Actinobacteria	I	Acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
HKD2_k127_6743119_2	96561.Dole_1280	3.459e-11	68.0	COG0451@1|root,COG0451@2|Bacteria,1MXKV@1224|Proteobacteria,42MI8@68525|delta/epsilon subdivisions,2WJDT@28221|Deltaproteobacteria,2MJA6@213118|Desulfobacterales	28221|Deltaproteobacteria	GM	PFAM NAD-dependent epimerase dehydratase	uxs	-	4.1.1.35	ko:K08678	ko00520,ko01100,map00520,map01100	M00361	R01384	RC00508	ko00000,ko00001,ko00002,ko01000	-	-	-	GDP_Man_Dehyd
HKD2_k127_6743119_3	1120949.KB903309_gene1111	3.511e-09	60.0	COG1359@1|root,COG1359@2|Bacteria,2GQYY@201174|Actinobacteria,4DG0W@85008|Micromonosporales	201174|Actinobacteria	S	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6743119_0	656024.FsymDg_3917	3.347e-166	537.0	COG0533@1|root,COG0533@2|Bacteria,2GJ98@201174|Actinobacteria,4ERH6@85013|Frankiales	201174|Actinobacteria	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction	tsaD	GO:0000408,GO:0002949,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Acetyltransf_1,Peptidase_M22
HKD2_k127_6743119_1	298653.Franean1_6006	6.63e-57	203.0	COG0454@1|root,COG0456@2|Bacteria,2IM9R@201174|Actinobacteria,4ESYS@85013|Frankiales	201174|Actinobacteria	K	Ribosomal-protein-alanine acetyltransferase	rimI	GO:0003674,GO:0003824,GO:0004596,GO:0006464,GO:0006473,GO:0006474,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019538,GO:0031365,GO:0034212,GO:0036211,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0051604,GO:0071704,GO:1901564	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1
HKD2_k127_6768567_9	1463858.JOHR01000005_gene1155	6.076e-15	80.0	COG1040@1|root,COG1040@2|Bacteria,2IFV8@201174|Actinobacteria	201174|Actinobacteria	S	competence protein	-	-	-	-	-	-	-	-	-	-	-	-	Pribosyltran
HKD2_k127_6768567_10	1169161.KB897714_gene6285	2.311e-12	73.0	COG1920@1|root,COG1920@2|Bacteria,2GQPF@201174|Actinobacteria	201174|Actinobacteria	S	GTP binding	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6768567_0	1123024.AUII01000022_gene109	1.458e-293	919.0	COG0855@1|root,COG0855@2|Bacteria,2GJ0B@201174|Actinobacteria,4DZMJ@85010|Pseudonocardiales	201174|Actinobacteria	P	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)	ppk	GO:0000287,GO:0001666,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0007154,GO:0008150,GO:0008152,GO:0008976,GO:0009267,GO:0009405,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0015968,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0019538,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0036211,GO:0036293,GO:0040007,GO:0042594,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044419,GO:0044464,GO:0046777,GO:0046872,GO:0050896,GO:0051704,GO:0051716,GO:0070482,GO:0071496,GO:0071704,GO:0071944,GO:1901564	2.7.4.1	ko:K00937	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PP_kinase,PP_kinase_C,PP_kinase_N
HKD2_k127_6768567_4	330084.JNYZ01000041_gene5080	3.237e-69	267.0	COG0494@1|root,COG2062@1|root,COG0494@2|Bacteria,COG2062@2|Bacteria,2GNRV@201174|Actinobacteria,4EF7E@85010|Pseudonocardiales	201174|Actinobacteria	LT	Belongs to the Nudix hydrolase family	mutT	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	His_Phos_1,NUDIX
HKD2_k127_6768567_5	222534.KB893794_gene2480	1.015e-40	155.0	COG0776@1|root,COG0776@2|Bacteria,2IKQR@201174|Actinobacteria,4EWU4@85013|Frankiales	201174|Actinobacteria	L	Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions	hup	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009889,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2001141	-	ko:K03530	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
HKD2_k127_6768567_3	298653.Franean1_1114	4.522e-99	326.0	COG0066@1|root,COG0066@2|Bacteria,2GJ8Z@201174|Actinobacteria,4ERFW@85013|Frankiales	201174|Actinobacteria	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuD	-	4.2.1.33,4.2.1.35	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R10170	RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase_C
HKD2_k127_6768567_1	656024.FsymDg_3707	2.341e-261	811.0	COG0065@1|root,COG0065@2|Bacteria,2GKT7@201174|Actinobacteria,4ERE0@85013|Frankiales	201174|Actinobacteria	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuC	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
HKD2_k127_6768567_2	656024.FsymDg_3711	2.877e-175	563.0	COG0642@1|root,COG2205@2|Bacteria,2IBA8@201174|Actinobacteria	201174|Actinobacteria	T	signal transduction histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
HKD2_k127_6768567_11	1033736.CAHK01000053_gene315	1.263e-07	62.0	COG2026@1|root,COG2026@2|Bacteria,2IRES@201174|Actinobacteria	201174|Actinobacteria	DJ	ParE toxin of type II toxin-antitoxin system, parDE	-	-	-	ko:K06218	-	-	-	-	ko00000,ko02048	-	-	-	ParE_toxin
HKD2_k127_6768567_13	1123024.AUII01000050_gene633	3.205e-06	51.0	COG3385@1|root,COG3385@2|Bacteria	2|Bacteria	L	transposase activity	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_4
HKD2_k127_6768567_7	345341.KUTG_07540	2.712e-26	117.0	COG3385@1|root,COG3385@2|Bacteria,2H68X@201174|Actinobacteria,4EAUY@85010|Pseudonocardiales	201174|Actinobacteria	L	Transposase DDE domain group 1	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_4
HKD2_k127_6768567_6	68570.DC74_906	8.598e-35	142.0	COG3293@1|root,COG3293@2|Bacteria,2IKID@201174|Actinobacteria	201174|Actinobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4096
HKD2_k127_6768567_8	1906.SFRA_07200	5.438e-20	91.0	COG1514@1|root,COG1514@2|Bacteria,2IFYV@201174|Actinobacteria	201174|Actinobacteria	J	2'-5' RNA ligase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	2_5_RNA_ligase2
HKD2_k127_679221_11	471852.Tcur_4539	1.122e-71	244.0	COG1774@1|root,COG1774@2|Bacteria,2HYDT@201174|Actinobacteria,4EFY6@85012|Streptosporangiales	201174|Actinobacteria	S	PSP1 C-terminal conserved region	-	-	-	-	-	-	-	-	-	-	-	-	PSP1
HKD2_k127_679221_5	656024.FsymDg_4342	4.306e-137	474.0	COG0470@1|root,COG0470@2|Bacteria,2GJ8C@201174|Actinobacteria,4ESBK@85013|Frankiales	201174|Actinobacteria	L	DNA polymerase III, delta'	holB	GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0032991,GO:0034641,GO:0034645,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:1901360,GO:1901576,GO:1902494,GO:1990234	2.7.7.7	ko:K02341	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNApol3-delta_C
HKD2_k127_679221_3	656024.FsymDg_4341	2.338e-261	822.0	COG0125@1|root,COG0477@1|root,COG0125@2|Bacteria,COG0477@2|Bacteria,2GNTI@201174|Actinobacteria,4ES48@85013|Frankiales	201174|Actinobacteria	EFGP	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis	tmk	-	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	MFS_3,Thymidylate_kin
HKD2_k127_679221_0	222534.KB893714_gene1564	0.0	1375.0	COG0550@1|root,COG1754@1|root,COG0550@2|Bacteria,COG1754@2|Bacteria,2GJU7@201174|Actinobacteria,4ES4C@85013|Frankiales	201174|Actinobacteria	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	GO:0000287,GO:0003674,GO:0003824,GO:0003916,GO:0003917,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0009892,GO:0010605,GO:0016020,GO:0016853,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031324,GO:0032069,GO:0032074,GO:0040007,GO:0043086,GO:0043167,GO:0043169,GO:0044092,GO:0044424,GO:0044444,GO:0044464,GO:0045934,GO:0046872,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051336,GO:0051346,GO:0060255,GO:0060700,GO:0060701,GO:0065007,GO:0065009,GO:0071944,GO:0080090,GO:0140097	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,Toprim_C_rpt
HKD2_k127_679221_15	644283.Micau_0447	2.032e-40	157.0	2EE2C@1|root,337X2@2|Bacteria,2GNPT@201174|Actinobacteria,4DDWK@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_679221_2	469371.Tbis_0223	0.0	1024.0	COG3808@1|root,COG3808@2|Bacteria,2GN8B@201174|Actinobacteria,4DY9J@85010|Pseudonocardiales	201174|Actinobacteria	C	Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
HKD2_k127_679221_16	298655.KI912266_gene1498	2.463e-40	157.0	COG2172@1|root,COG2172@2|Bacteria,2IHNR@201174|Actinobacteria,4EW59@85013|Frankiales	201174|Actinobacteria	T	Histidine kinase-like ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c_2
HKD2_k127_679221_12	298655.KI912266_gene1499	2.351e-59	207.0	COG1366@1|root,COG1366@2|Bacteria,2IHQG@201174|Actinobacteria,4ESTZ@85013|Frankiales	201174|Actinobacteria	T	Belongs to the anti-sigma-factor antagonist family	rsbV	GO:0003674,GO:0005488,GO:0005515,GO:0042802	-	ko:K04749	-	-	-	-	ko00000,ko03021	-	-	-	STAS
HKD2_k127_679221_1	298653.Franean1_0313	0.0	1095.0	COG0514@1|root,COG1205@1|root,COG0514@2|Bacteria,COG1205@2|Bacteria,2GJJ6@201174|Actinobacteria,4ERHU@85013|Frankiales	201174|Actinobacteria	L	DEAD DEAH box helicase	-	-	-	ko:K06877	-	-	-	-	ko00000	-	-	-	DEAD,DUF1998,Helicase_C
HKD2_k127_679221_20	235985.BBPN01000014_gene5437	1.695e-17	89.0	2CABD@1|root,347XM@2|Bacteria,2IRFI@201174|Actinobacteria,2NMBV@228398|Streptacidiphilus	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_679221_22	710111.FraQA3DRAFT_5152	0.0001926	51.0	2DRBM@1|root,33B4F@2|Bacteria,2HU37@201174|Actinobacteria,4EWRN@85013|Frankiales	201174|Actinobacteria	S	TIGRFAM helicase secretion neighborhood TadE-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Tad
HKD2_k127_679221_21	710111.FraQA3DRAFT_5154	3.583e-10	67.0	2EHCF@1|root,33B4A@2|Bacteria,2I1J6@201174|Actinobacteria,4ETH4@85013|Frankiales	201174|Actinobacteria	S	Protein of unknown function (DUF4244)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4244
HKD2_k127_679221_17	656024.FsymDg_4304	8.044e-29	132.0	COG2064@1|root,COG2064@2|Bacteria,2GR12@201174|Actinobacteria	201174|Actinobacteria	NU	Type ii secretion system	gspF	-	-	ko:K12510	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
HKD2_k127_679221_18	298654.FraEuI1c_0327	2.086e-24	113.0	COG2064@1|root,COG4965@1|root,COG2064@2|Bacteria,COG4965@2|Bacteria,2GR12@201174|Actinobacteria,4EXDM@85013|Frankiales	201174|Actinobacteria	NU	Type II secretion system (T2SS), protein F	gspF	-	-	ko:K12510	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
HKD2_k127_679221_6	58344.JOEL01000007_gene4504	1.987e-134	458.0	COG4962@1|root,COG4962@2|Bacteria,2GKKJ@201174|Actinobacteria	201174|Actinobacteria	U	Type ii secretion system protein e	cpaF	-	-	ko:K02283	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
HKD2_k127_679221_7	452652.KSE_35920	5.658e-105	368.0	COG0455@1|root,COG0455@2|Bacteria,2GIVN@201174|Actinobacteria,2M1XQ@2063|Kitasatospora	201174|Actinobacteria	D	bacterial-type flagellum organization	cpaE	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464	-	-	-	-	-	-	-	-	-	-	CbiA
HKD2_k127_679221_8	1463879.JOHP01000012_gene1066	1.123e-100	335.0	COG0560@1|root,COG0560@2|Bacteria,2GJVX@201174|Actinobacteria	201174|Actinobacteria	E	HAD-superfamily subfamily IB hydrolase, TIGR01490	serB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	-	-	-	-	-	-	-	-	-	HAD
HKD2_k127_679221_10	298655.KI912266_gene1506	1.478e-77	267.0	COG3177@1|root,COG3177@2|Bacteria,2GIT8@201174|Actinobacteria,4ESV3@85013|Frankiales	201174|Actinobacteria	S	Filamentation induced by cAMP protein fic	-	-	-	-	-	-	-	-	-	-	-	-	Fic
HKD2_k127_679221_14	106370.Francci3_4294	2.002e-42	160.0	2DPPE@1|root,332VJ@2|Bacteria,2IN30@201174|Actinobacteria,4ETAT@85013|Frankiales	201174|Actinobacteria	S	Putative Actinobacterial Holin-X, holin superfamily III	-	-	-	-	-	-	-	-	-	-	-	-	Phage_holin_3_6
HKD2_k127_679221_4	656024.FsymDg_4310	1.203e-154	492.0	COG0596@1|root,COG0596@2|Bacteria,2GJDM@201174|Actinobacteria,4ERY9@85013|Frankiales	201174|Actinobacteria	S	PFAM Alpha beta hydrolase	ephE	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
HKD2_k127_679221_13	103733.JNYO01000059_gene8774	7.061e-45	183.0	COG1547@1|root,COG1547@2|Bacteria,2IHUS@201174|Actinobacteria,4E44P@85010|Pseudonocardiales	201174|Actinobacteria	S	Domain of unknown function (DUF309)	-	-	-	ko:K09763	-	-	-	-	ko00000	-	-	-	DUF309
HKD2_k127_679221_9	298654.FraEuI1c_0332	3.195e-94	314.0	COG0265@1|root,COG0265@2|Bacteria,2GJ92@201174|Actinobacteria,4EREG@85013|Frankiales	201174|Actinobacteria	O	Colicin V production protein	cvpA	GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0009268,GO:0009405,GO:0009628,GO:0010447,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044419,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051704,GO:0071944	-	-	-	-	-	-	-	-	-	-	Colicin_V,Trypsin_2
HKD2_k127_681829_5	222534.KB893794_gene2535	3.712e-93	313.0	COG0758@1|root,COG0758@2|Bacteria,2GKDA@201174|Actinobacteria,4ESKB@85013|Frankiales	201174|Actinobacteria	LU	DNA protecting protein DprA	dprA	-	-	ko:K04096	-	-	-	-	ko00000	-	-	-	DNA_processg_A
HKD2_k127_681829_2	106370.Francci3_3583	3.409e-107	361.0	COG4974@1|root,COG4974@2|Bacteria,2GNDP@201174|Actinobacteria,4ERBN@85013|Frankiales	201174|Actinobacteria	L	Belongs to the 'phage' integrase family. XerC subfamily	xerC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03733,ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
HKD2_k127_681829_8	656024.FsymDg_3663	2.773e-36	155.0	COG0739@1|root,COG0739@2|Bacteria,2IQ64@201174|Actinobacteria,4ET1M@85013|Frankiales	201174|Actinobacteria	M	PFAM peptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
HKD2_k127_681829_0	656024.FsymDg_3662	1.19e-148	480.0	COG0052@1|root,COG0052@2|Bacteria,2GMYC@201174|Actinobacteria,4ES0W@85013|Frankiales	201174|Actinobacteria	J	Belongs to the universal ribosomal protein uS2 family	rpsB	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0022626,GO:0022627,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
HKD2_k127_681829_4	656024.FsymDg_3661	7.933e-102	334.0	COG0264@1|root,COG0264@2|Bacteria,2GK4M@201174|Actinobacteria,4ERRY@85013|Frankiales	201174|Actinobacteria	J	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome	tsf	GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0019538,GO:0030312,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K02357	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EF_TS
HKD2_k127_681829_1	298654.FraEuI1c_1082	4.944e-119	394.0	COG0528@1|root,COG0528@2|Bacteria,2GKWQ@201174|Actinobacteria,4ERFG@85013|Frankiales	201174|Actinobacteria	F	Catalyzes the reversible phosphorylation of UMP to UDP	pyrH	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006213,GO:0006220,GO:0006221,GO:0006225,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009163,GO:0009165,GO:0009185,GO:0009188,GO:0009193,GO:0009194,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019693,GO:0033862,GO:0034404,GO:0034641,GO:0034654,GO:0040007,GO:0042455,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046048,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0046872,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
HKD2_k127_681829_6	222534.KB893794_gene2540	1.399e-92	307.0	COG0233@1|root,COG0233@2|Bacteria,2GJ9J@201174|Actinobacteria,4ESC9@85013|Frankiales	201174|Actinobacteria	J	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another	frr	GO:0002181,GO:0002184,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022411,GO:0030312,GO:0032984,GO:0034641,GO:0034645,GO:0040007,GO:0043021,GO:0043023,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K02838	-	-	-	-	ko00000,ko03012	-	-	-	RRF
HKD2_k127_681829_3	298655.KI912267_gene6691	4.017e-102	340.0	COG4589@1|root,COG4589@2|Bacteria,2GNWK@201174|Actinobacteria,4ES47@85013|Frankiales	201174|Actinobacteria	S	Belongs to the CDS family	cdsA	GO:0003674,GO:0003824,GO:0004605,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006220,GO:0006221,GO:0006629,GO:0006644,GO:0006650,GO:0006655,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009117,GO:0009165,GO:0009987,GO:0016020,GO:0016024,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019637,GO:0030312,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044281,GO:0044464,GO:0045017,GO:0046341,GO:0046471,GO:0046474,GO:0046483,GO:0046486,GO:0055086,GO:0070567,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.7.41	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_1
HKD2_k127_681829_7	471852.Tcur_3404	2.958e-54	194.0	COG0820@1|root,COG0820@2|Bacteria,2GJ48@201174|Actinobacteria,4EID1@85012|Streptosporangiales	201174|Actinobacteria	J	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs	rlmN	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0030312,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:0140102,GO:1901360	2.1.1.192	ko:K06941	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Radical_SAM
HKD2_k127_6835799_2	215803.DB30_7715	3.558e-21	105.0	COG3507@1|root,COG3507@2|Bacteria	2|Bacteria	G	Belongs to the glycosyl hydrolase 43 family	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_43
HKD2_k127_6835799_3	28444.JODQ01000004_gene6224	4.182e-13	77.0	COG3664@1|root,COG3664@2|Bacteria,2I92N@201174|Actinobacteria,4EFWW@85012|Streptosporangiales	201174|Actinobacteria	G	PFAM glycoside hydrolase family 39	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_39
HKD2_k127_6835799_1	1283283.ATXA01000005_gene1964	1.767e-52	196.0	COG0726@1|root,COG0726@2|Bacteria,2GMC2@201174|Actinobacteria,4EX43@85013|Frankiales	201174|Actinobacteria	G	Polysaccharide deacetylase	-	-	3.5.1.104	ko:K22278	-	-	-	-	ko00000,ko01000	-	-	-	Polysacc_deac_1
HKD2_k127_6835799_0	471852.Tcur_3608	4.356e-192	621.0	COG0616@1|root,COG0616@2|Bacteria,2HQDG@201174|Actinobacteria,4EHD6@85012|Streptosporangiales	201174|Actinobacteria	OU	Peptidase family S49	sppA	-	-	ko:K04773,ko:K04774	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S49
HKD2_k127_6835799_4	1211815.CBYP010000024_gene1530	5.554e-07	51.0	COG0148@1|root,COG0148@2|Bacteria,2GJAY@201174|Actinobacteria,4ERMF@85013|Frankiales	201174|Actinobacteria	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
HKD2_k127_6840615_1	479433.Caci_3772	8.52e-93	340.0	COG0297@1|root,COG0297@2|Bacteria,2I2EE@201174|Actinobacteria	201174|Actinobacteria	G	PFAM Glycosyl transferase, group 1	-	GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016740,GO:0016757,GO:0033692,GO:0034637,GO:0034645,GO:0040007,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	2.4.1.11	ko:K16150	ko00500,ko01100,map00500,map01100	-	R00292	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT4	-	Glyco_transf_4,Glycos_transf_1
HKD2_k127_6840615_0	656024.FsymDg_3788	9.602e-213	676.0	COG1543@1|root,COG1543@2|Bacteria,2GKTI@201174|Actinobacteria	201174|Actinobacteria	G	Belongs to the glycosyl hydrolase 57 family	-	GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	2.4.1.18	ko:K16149	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000	-	GH57	-	DUF1957,Glyco_hydro_57
HKD2_k127_6840615_2	1123023.JIAI01000006_gene150	8.051e-81	279.0	COG2227@1|root,COG2227@2|Bacteria,2GMMX@201174|Actinobacteria,4DXPQ@85010|Pseudonocardiales	201174|Actinobacteria	H	PFAM Methyltransferase domain	-	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0016020,GO:0016740,GO:0016741,GO:0032259,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	2.1.1.222,2.1.1.64	ko:K00568	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04988,R05614,R08769,R08781	RC00003,RC00392,RC01895	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_11,Methyltransf_23
HKD2_k127_6887538_0	365528.KB891239_gene6018	2.352e-22	102.0	COG3655@1|root,COG3655@2|Bacteria,2INIS@201174|Actinobacteria	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_26,HTH_31
HKD2_k127_6887538_1	1146883.BLASA_2856	1.053e-09	61.0	2CC1Y@1|root,32RUK@2|Bacteria,2IQ4Q@201174|Actinobacteria	201174|Actinobacteria	K	Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA	whmD	-	-	ko:K18955	-	-	-	-	ko00000,ko03000	-	-	-	Whib
HKD2_k127_6887538_2	1906.SFRA_17740	0.0004414	48.0	29ZDT@1|root,30MCU@2|Bacteria,2H03N@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6898738_0	365528.KB891241_gene6215	0.0	1083.0	COG1201@1|root,COG1201@2|Bacteria,2GJG3@201174|Actinobacteria,4ES42@85013|Frankiales	201174|Actinobacteria	L	DEAD DEAH box helicase domain protein	lhr	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,HTH_42,Helicase_C
HKD2_k127_6898738_17	710111.FraQA3DRAFT_5867	2.387e-23	102.0	2EFU9@1|root,339KE@2|Bacteria,2GQJW@201174|Actinobacteria,4ETFQ@85013|Frankiales	201174|Actinobacteria	S	Protein of unknown function (DUF3046)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3046
HKD2_k127_6898738_5	298653.Franean1_1219	9.137e-195	612.0	COG0468@1|root,COG0468@2|Bacteria,2GJ4P@201174|Actinobacteria,4ERDP@85013|Frankiales	201174|Actinobacteria	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage	recA	GO:0000150,GO:0000166,GO:0000287,GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009314,GO:0009411,GO:0009416,GO:0009432,GO:0009605,GO:0009628,GO:0009650,GO:0009987,GO:0009991,GO:0016462,GO:0016787,GO:0016788,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0030145,GO:0030554,GO:0031668,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0034641,GO:0035639,GO:0036094,GO:0042148,GO:0042221,GO:0042623,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046677,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0090304,GO:0090305,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363	-	ko:K03553	ko03440,map03440	M00729	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	RecA
HKD2_k127_6898738_16	219305.MCAG_04420	3.971e-43	165.0	COG2137@1|root,COG2137@2|Bacteria,2GMRF@201174|Actinobacteria,4DD5X@85008|Micromonosporales	201174|Actinobacteria	S	Modulates RecA activity	recX	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03565	-	-	-	-	ko00000,ko03400	-	-	-	RecX
HKD2_k127_6898738_3	656024.FsymDg_3608	3.756e-231	733.0	COG1418@1|root,COG1418@2|Bacteria,2I9DW@201174|Actinobacteria,4EUJT@85013|Frankiales	201174|Actinobacteria	A	Endoribonuclease that initiates mRNA decay	rny	-	-	ko:K18682	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DUF3552,HD,KH_1
HKD2_k127_6898738_11	298655.KI912266_gene3102	1.47e-90	319.0	COG0765@1|root,COG0765@2|Bacteria,2GNBH@201174|Actinobacteria,4ESSB@85013|Frankiales	201174|Actinobacteria	P	polar amino acid ABC transporter, inner membrane subunit	gluD	-	-	ko:K10007	ko02010,map02010	M00233	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3.9	-	-	BPD_transp_1
HKD2_k127_6898738_13	298655.KI912266_gene3103	1.922e-78	267.0	COG0765@1|root,COG0765@2|Bacteria,2GNUR@201174|Actinobacteria,4ESRF@85013|Frankiales	201174|Actinobacteria	P	polar amino acid ABC transporter, inner membrane subunit	-	-	-	ko:K10006	ko02010,map02010	M00233	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3.9	-	-	BPD_transp_1
HKD2_k127_6898738_18	326424.FRAAL5714	4.492e-19	87.0	COG0834@1|root,COG0834@2|Bacteria,2GJH8@201174|Actinobacteria,4ESNV@85013|Frankiales	201174|Actinobacteria	ET	PFAM Extracellular solute-binding protein, family 3	gluB	-	-	ko:K10005	ko02010,map02010	M00233	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3.9	-	-	SBP_bac_3
HKD2_k127_6898738_9	298655.KI912266_gene3104	7.984e-98	325.0	COG0834@1|root,COG0834@2|Bacteria,2GJH8@201174|Actinobacteria,4ESNV@85013|Frankiales	201174|Actinobacteria	ET	PFAM Extracellular solute-binding protein, family 3	gluB	-	-	ko:K10005	ko02010,map02010	M00233	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3.9	-	-	SBP_bac_3
HKD2_k127_6898738_6	298655.KI912266_gene3105	6.907e-119	387.0	COG1126@1|root,COG1126@2|Bacteria,2GIZW@201174|Actinobacteria,4ES6N@85013|Frankiales	201174|Actinobacteria	E	PFAM ABC transporter	-	-	-	ko:K10008	ko02010,map02010	M00233	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.3.9	-	-	ABC_tran
HKD2_k127_6898738_2	526225.Gobs_3911	1.07e-232	734.0	COG0621@1|root,COG0621@2|Bacteria,2GJEV@201174|Actinobacteria,4ERFI@85013|Frankiales	201174|Actinobacteria	J	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine	miaB	-	2.8.4.3	ko:K06168	-	-	R10645,R10646,R10647	RC00003,RC00980,RC03221,RC03222	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
HKD2_k127_6898738_15	656024.FsymDg_3606	5.439e-64	240.0	COG3885@1|root,COG3885@2|Bacteria,2GN3T@201174|Actinobacteria,4ESYY@85013|Frankiales	201174|Actinobacteria	S	ferrous iron binding	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6898738_7	656024.FsymDg_3602	8.563e-117	405.0	COG0324@1|root,COG0324@2|Bacteria,2GKFT@201174|Actinobacteria,4ERN4@85013|Frankiales	201174|Actinobacteria	J	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)	miaA	GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016765,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0052381,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.5.1.75	ko:K00791	ko00908,ko01100,ko01110,map00908,map01100,map01110	-	R01122	RC02820	ko00000,ko00001,ko01000,ko01006,ko03016	-	-	-	IPPT
HKD2_k127_6898738_12	656024.FsymDg_3603	1.007e-88	301.0	COG2200@1|root,COG2200@2|Bacteria,2H578@201174|Actinobacteria	201174|Actinobacteria	T	EAL domain	-	GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008081,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009166,GO:0009187,GO:0009214,GO:0009987,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0040007,GO:0042578,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044403,GO:0044419,GO:0046434,GO:0046483,GO:0046700,GO:0051704,GO:0055086,GO:0071111,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS_3,Response_reg
HKD2_k127_6898738_8	298653.Franean1_1230	8.166e-108	355.0	COG0253@1|root,COG0253@2|Bacteria,2GKUD@201174|Actinobacteria,4ESJJ@85013|Frankiales	201174|Actinobacteria	E	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan	dapF	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008837,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016020,GO:0016053,GO:0016853,GO:0016854,GO:0016855,GO:0019752,GO:0036361,GO:0040007,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0047661,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	5.1.1.7	ko:K01778	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00527	R02735	RC00302	ko00000,ko00001,ko00002,ko01000	-	-	-	DAP_epimerase
HKD2_k127_6898738_4	710111.FraQA3DRAFT_5883	4.641e-215	679.0	COG2262@1|root,COG2262@2|Bacteria,2GK55@201174|Actinobacteria,4ERJ5@85013|Frankiales	201174|Actinobacteria	S	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis	hflX	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0044424,GO:0044464	-	ko:K03665	-	-	-	-	ko00000,ko03009	-	-	-	GTP-bdg_M,GTP-bdg_N,MMR_HSR1
HKD2_k127_6898738_10	211114.JOEF01000004_gene6659	2.457e-96	321.0	COG1974@1|root,COG1974@2|Bacteria,2GMBN@201174|Actinobacteria,4E040@85010|Pseudonocardiales	201174|Actinobacteria	K	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair	lexA	GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0006355,GO:0006950,GO:0006974,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032991,GO:0032993,GO:0033554,GO:0042221,GO:0043565,GO:0044212,GO:0044464,GO:0045892,GO:0045934,GO:0046677,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051716,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001141	3.4.21.88	ko:K01356	-	M00729	-	-	ko00000,ko00002,ko01000,ko01002,ko03400	-	-	-	LexA_DNA_bind,Peptidase_S24
HKD2_k127_6898738_19	656024.FsymDg_3600	0.0005772	49.0	COG1388@1|root,COG1388@2|Bacteria,2GWI9@201174|Actinobacteria,4ETIZ@85013|Frankiales	201174|Actinobacteria	M	Lysin motif	-	-	-	-	-	-	-	-	-	-	-	-	LysM
HKD2_k127_6898738_14	656024.FsymDg_3599	6.466e-70	242.0	COG1327@1|root,COG1327@2|Bacteria,2IHU9@201174|Actinobacteria,4ESK4@85013|Frankiales	201174|Actinobacteria	K	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes	nrdR	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K07738	-	-	-	-	ko00000,ko03000	-	-	-	ATP-cone
HKD2_k127_6898738_1	526225.Gobs_3898	6.485e-278	861.0	COG0209@1|root,COG0209@2|Bacteria,2GKX9@201174|Actinobacteria,4ERKQ@85013|Frankiales	201174|Actinobacteria	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	nrdJ	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_2_N,Ribonuc_red_lgC
HKD2_k127_6905290_0	326424.FRAAL1923	1.707e-221	709.0	COG1530@1|root,COG1530@2|Bacteria,2GMM5@201174|Actinobacteria,4ERY4@85013|Frankiales	201174|Actinobacteria	J	ribonuclease, Rne Rng family	rne	-	3.1.26.12	ko:K08300,ko:K08301	ko03018,map03018	M00394	-	-	ko00000,ko00001,ko00002,ko01000,ko03009,ko03019	-	-	-	IF2_N,RNase_E_G,S1
HKD2_k127_6905290_1	526225.Gobs_1586	4.303e-89	307.0	COG5011@1|root,COG5011@2|Bacteria,2GIS7@201174|Actinobacteria,4ESGF@85013|Frankiales	201174|Actinobacteria	S	Uncharacterized protein conserved in bacteria (DUF2344)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2344
HKD2_k127_6905290_2	1122611.KB903990_gene7261	1.403e-69	237.0	COG1032@1|root,COG1032@2|Bacteria,2GJY1@201174|Actinobacteria,4EFRZ@85012|Streptosporangiales	201174|Actinobacteria	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
HKD2_k127_691204_5	66429.JOFL01000006_gene2164	2.672e-50	185.0	COG5516@1|root,COG5516@2|Bacteria,2GNZF@201174|Actinobacteria	201174|Actinobacteria	S	Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding	-	-	-	-	-	-	-	-	-	-	-	-	zf-CGNR
HKD2_k127_691204_9	66429.JOFL01000006_gene2165	1.692e-16	85.0	COG5424@1|root,COG5424@2|Bacteria	2|Bacteria	H	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ	-	-	1.3.3.11	ko:K06137	-	-	-	-	ko00000,ko01000	-	-	-	Haem_oxygenas_2
HKD2_k127_691204_4	298654.FraEuI1c_5123	3.209e-65	230.0	COG0698@1|root,COG0698@2|Bacteria,2GKJG@201174|Actinobacteria,4ESNQ@85013|Frankiales	201174|Actinobacteria	G	PFAM Ribose galactose isomerase	rpiB	-	5.3.1.6	ko:K01808	ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01056,R09030	RC00376,RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	LacAB_rpiB
HKD2_k127_691204_3	222534.KB893671_gene3096	2.531e-92	308.0	COG3917@1|root,COG3917@2|Bacteria,2I2EX@201174|Actinobacteria,4ESH1@85013|Frankiales	201174|Actinobacteria	Q	DSBA oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DSBA
HKD2_k127_691204_2	710111.FraQA3DRAFT_3178	2.412e-114	384.0	COG0628@1|root,COG0628@2|Bacteria,2GK0H@201174|Actinobacteria,4ESP8@85013|Frankiales	201174|Actinobacteria	S	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
HKD2_k127_691204_0	656024.FsymDg_1497	0.0	1311.0	COG0308@1|root,COG0308@2|Bacteria,2GJJ4@201174|Actinobacteria,4ES10@85013|Frankiales	201174|Actinobacteria	E	PFAM Peptidase M1, membrane alanine aminopeptidase	pepN	-	3.4.11.2	ko:K01256,ko:K08776	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	ERAP1_C,Peptidase_M1
HKD2_k127_691204_8	526225.Gobs_3713	9.484e-27	114.0	299PR@1|root,2ZWS2@2|Bacteria,2HCZT@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_691204_6	526225.Gobs_3712	7.235e-39	152.0	COG2337@1|root,COG2337@2|Bacteria,2IMUI@201174|Actinobacteria	201174|Actinobacteria	T	PemK-like, MazF-like toxin of type II toxin-antitoxin system	-	-	-	ko:K07171	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PemK_toxin
HKD2_k127_691204_7	298653.Franean1_5307	1.818e-37	149.0	COG1512@1|root,COG1512@2|Bacteria,2GTMP@201174|Actinobacteria,4EXAS@85013|Frankiales	201174|Actinobacteria	S	Domain of unknown function (DUF5130)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5130
HKD2_k127_691204_10	477641.MODMU_1551	4.731e-06	59.0	2EGNC@1|root,33AEH@2|Bacteria,2GQSG@201174|Actinobacteria,4EWQI@85013|Frankiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_691204_1	365528.KB891215_gene2616	1.946e-241	769.0	COG1640@1|root,COG1640@2|Bacteria,2GM5Z@201174|Actinobacteria,4ERC9@85013|Frankiales	201174|Actinobacteria	G	PFAM glycoside hydrolase family 77	malQ	-	2.4.1.25	ko:K00705	ko00500,ko01100,map00500,map01100	-	R05196	RC00049	ko00000,ko00001,ko01000	-	GH77	-	Glyco_hydro_77
HKD2_k127_6915030_13	1382356.JQMP01000003_gene1653	3.995e-05	50.0	2BJKH@1|root,32DXQ@2|Bacteria,2GBQP@200795|Chloroflexi,27Z85@189775|Thermomicrobia	189775|Thermomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6915030_8	1382356.JQMP01000003_gene1711	4.689e-19	101.0	COG0699@1|root,COG0699@2|Bacteria,2GAC1@200795|Chloroflexi,27ZB1@189775|Thermomicrobia	189775|Thermomicrobia	S	Dynamin family	-	-	-	-	-	-	-	-	-	-	-	-	Dynamin_N
HKD2_k127_6915030_9	706587.Desti_5378	5.598e-18	92.0	COG0699@1|root,COG0699@2|Bacteria,1MXBK@1224|Proteobacteria,42PVB@68525|delta/epsilon subdivisions,2WIMK@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	PFAM Dynamin family	-	-	-	-	-	-	-	-	-	-	-	-	Dynamin_N
HKD2_k127_6915030_3	1122611.KB903955_gene5456	6.733e-141	467.0	COG0148@1|root,COG0148@2|Bacteria,2IA5M@201174|Actinobacteria,4ENC2@85012|Streptosporangiales	201174|Actinobacteria	G	Enolase, N-terminal domain	eno2	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
HKD2_k127_6915030_11	1246448.ANAZ01000008_gene2407	1.204e-08	62.0	COG1993@1|root,COG1993@2|Bacteria,2IM7J@201174|Actinobacteria,4EK9R@85012|Streptosporangiales	201174|Actinobacteria	S	Uncharacterized ACR, COG1993	-	-	-	ko:K09137	-	-	-	-	ko00000	-	-	-	DUF190
HKD2_k127_6915030_0	1415166.NONO_c49670	1.454e-212	692.0	COG0651@1|root,COG0651@2|Bacteria,2HAC7@201174|Actinobacteria,4FW5S@85025|Nocardiaceae	201174|Actinobacteria	CP	Subunit D of antiporter complex involved in resistance to high concentrations of Na , K , Li and or alkali	-	-	-	-	-	-	-	-	-	-	-	-	Proton_antipo_M
HKD2_k127_6915030_5	1120797.KB908259_gene945	2.059e-98	327.0	COG3260@1|root,COG3260@2|Bacteria,2I7C2@201174|Actinobacteria,23EWJ@1762|Mycobacteriaceae	201174|Actinobacteria	C	NADH ubiquinone oxidoreductase, 20 Kd subunit	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_15,Oxidored_q6
HKD2_k127_6915030_2	1415166.NONO_c49690	7.068e-169	566.0	COG0852@1|root,COG3261@1|root,COG0852@2|Bacteria,COG3261@2|Bacteria,2GYM5@201174|Actinobacteria,4G23Q@85025|Nocardiaceae	201174|Actinobacteria	C	Respiratory-chain NADH dehydrogenase, 30 Kd subunit	-	-	-	ko:K15830	-	-	-	-	ko00000	-	-	-	Complex1_30kDa,Complex1_49kDa,NiFeSe_Hases
HKD2_k127_6915030_1	1157638.KB892189_gene5621	3.982e-197	625.0	COG0651@1|root,COG0651@2|Bacteria,2HAC7@201174|Actinobacteria	201174|Actinobacteria	CP	Formate hydrogenlyase subunit 3 Multisubunit Na H antiporter, MnhD subunit	-	-	-	ko:K12141	-	-	-	-	ko00000,ko01000	-	-	-	Proton_antipo_M
HKD2_k127_6915030_6	1120797.KB908259_gene948	2.065e-74	274.0	COG4237@1|root,COG4237@2|Bacteria,2HQ3P@201174|Actinobacteria,2368F@1762|Mycobacteriaceae	201174|Actinobacteria	C	Hydrogenase 4 membrane	-	-	-	ko:K12140	-	-	-	-	ko00000,ko01000	-	-	-	-
HKD2_k127_6915030_4	351607.Acel_0731	1.025e-117	382.0	COG0650@1|root,COG0650@2|Bacteria,2GJFM@201174|Actinobacteria,4ESWZ@85013|Frankiales	201174|Actinobacteria	C	NADH dehydrogenase	-	-	-	ko:K12138	-	-	-	-	ko00000,ko01000	-	-	-	NADHdh
HKD2_k127_6915030_10	1416759.AYMR01000033_gene4191	1.067e-15	88.0	COG0650@1|root,COG0650@2|Bacteria,2GJFM@201174|Actinobacteria,4FPM3@85023|Microbacteriaceae	201174|Actinobacteria	C	NADH dehydrogenase	-	-	-	ko:K12138	-	-	-	-	ko00000,ko01000	-	-	-	NADHdh
HKD2_k127_6915030_12	68170.KL590553_gene5142	1.07e-06	57.0	2BTG8@1|root,2ZHDF@2|Bacteria,2GZRA@201174|Actinobacteria,4ECRB@85010|Pseudonocardiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6915030_7	1157638.KB892189_gene5629	8.978e-34	136.0	COG1051@1|root,COG1051@2|Bacteria,2IJJ2@201174|Actinobacteria	201174|Actinobacteria	F	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
HKD2_k127_6918765_18	106370.Francci3_3838	1.171e-06	54.0	2DR5U@1|root,33AAR@2|Bacteria,2GX63@201174|Actinobacteria,4EXBY@85013|Frankiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6918765_2	656024.FsymDg_0848	3.948e-148	476.0	COG0294@1|root,COG0294@2|Bacteria,2GJNI@201174|Actinobacteria,4ERSY@85013|Frankiales	201174|Actinobacteria	H	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives	folP2	-	2.5.1.15	ko:K00796	ko00790,ko01100,map00790,map01100	M00126,M00841	R03066,R03067	RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
HKD2_k127_6918765_17	106370.Francci3_0974	1.278e-08	68.0	2DRJD@1|root,33C0U@2|Bacteria,2GXPP@201174|Actinobacteria,4EX0K@85013|Frankiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6918765_5	2074.JNYD01000005_gene3197	1.74e-110	362.0	COG1611@1|root,COG1611@2|Bacteria,2GKJH@201174|Actinobacteria,4DYE4@85010|Pseudonocardiales	201174|Actinobacteria	S	Belongs to the LOG family	fmt2	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
HKD2_k127_6918765_7	1220583.GOACH_19_00960	9.508e-88	294.0	COG0693@1|root,COG0693@2|Bacteria,2GMMW@201174|Actinobacteria,4GBXS@85026|Gordoniaceae	201174|Actinobacteria	S	DJ-1/PfpI family	yfkM	-	3.5.1.124	ko:K05520	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	DJ-1_PfpI
HKD2_k127_6918765_14	1033743.CAES01000080_gene3899	3.104e-20	95.0	COG0655@1|root,COG0655@2|Bacteria,1TSY9@1239|Firmicutes,4H9MQ@91061|Bacilli,26SJP@186822|Paenibacillaceae	91061|Bacilli	S	Belongs to the WrbA family	wrbA	-	1.6.5.2	ko:K03809	ko00130,ko01110,map00130,map01110	-	R02964,R03643,R03816	RC00819	ko00000,ko00001,ko01000	-	-	-	FMN_red
HKD2_k127_6918765_11	1133850.SHJG_1840	2.482e-44	175.0	COG0655@1|root,COG0655@2|Bacteria,2GTN2@201174|Actinobacteria	201174|Actinobacteria	IQ	Belongs to the WrbA family	-	-	1.6.5.2	ko:K03809	ko00130,ko01110,map00130,map01110	-	R02964,R03643,R03816	RC00819	ko00000,ko00001,ko01000	-	-	-	FMN_red,YceI
HKD2_k127_6918765_0	928724.SacglDRAFT_03391	1.45e-218	687.0	COG1012@1|root,COG1012@2|Bacteria,2GIWZ@201174|Actinobacteria,4DYJK@85010|Pseudonocardiales	201174|Actinobacteria	C	Belongs to the aldehyde dehydrogenase family	gabD3	-	1.2.1.16,1.2.1.20,1.2.1.79	ko:K00135	ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120	M00027	R00713,R00714,R02401	RC00080	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
HKD2_k127_6918765_4	105422.BBPM01000045_gene1608	3.325e-140	454.0	COG0624@1|root,COG0624@2|Bacteria,2GK09@201174|Actinobacteria,2NEAY@228398|Streptacidiphilus	201174|Actinobacteria	E	Peptidase family M28	dapE	-	3.5.1.18	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R02734	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
HKD2_k127_6918765_3	710111.FraQA3DRAFT_5505	3.077e-144	460.0	COG2171@1|root,COG2171@2|Bacteria,2IBDI@201174|Actinobacteria,4ES9H@85013|Frankiales	201174|Actinobacteria	E	Belongs to the transferase hexapeptide repeat family	dapD	-	2.3.1.117	ko:K00674	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R04365	RC00004,RC01136	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,Hexapep_2,THDPS_N_2
HKD2_k127_6918765_8	1449347.JQLN01000005_gene3455	7.141e-72	248.0	COG2229@1|root,COG2229@2|Bacteria,2GJIT@201174|Actinobacteria,2M260@2063|Kitasatospora	201174|Actinobacteria	S	Conserved hypothetical ATP binding protein	-	-	-	ko:K06945	-	-	-	-	ko00000	-	-	-	ATP_bind_1
HKD2_k127_6918765_15	1449976.KALB_1772	5.645e-12	76.0	COG1846@1|root,COG1846@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	-	-	2.7.1.83	ko:K16328	ko00240,map00240	-	R03315	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	DUF3489,DUF742
HKD2_k127_6918765_13	345341.KUTG_04637	2.246e-38	147.0	COG2018@1|root,COG2018@2|Bacteria,2IFB7@201174|Actinobacteria,4E2K7@85010|Pseudonocardiales	201174|Actinobacteria	S	PFAM Roadblock LC7	cvnB7	-	-	ko:K07131	-	-	-	-	ko00000	-	-	-	Robl_LC7
HKD2_k127_6918765_9	1122182.KB903814_gene3070	7.312e-65	243.0	COG0642@1|root,COG0642@2|Bacteria,2GKY7@201174|Actinobacteria,4D9BD@85008|Micromonosporales	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,NIT
HKD2_k127_6918765_16	645991.Sgly_2812	3.415e-10	72.0	COG0840@1|root,COG0840@2|Bacteria,1TP5A@1239|Firmicutes,247S3@186801|Clostridia,261ZQ@186807|Peptococcaceae	186801|Clostridia	NT	Methyl-accepting chemotaxis protein (MCP) signaling domain	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	4HB_MCP_1,HAMP,MCPsignal,dCache_1
HKD2_k127_6918765_1	656024.FsymDg_0843	3.008e-180	577.0	COG0436@1|root,COG0436@2|Bacteria,2GJMI@201174|Actinobacteria,4ERPG@85013|Frankiales	201174|Actinobacteria	E	PFAM Aminotransferase class I and II	dapC	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
HKD2_k127_6918765_10	326424.FRAAL6126	4.057e-57	200.0	COG1146@1|root,COG1146@2|Bacteria,2IKVN@201174|Actinobacteria,4ESV9@85013|Frankiales	201174|Actinobacteria	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	fdxA	-	-	ko:K05524	-	-	-	-	ko00000	-	-	-	Fer4
HKD2_k127_6918765_6	656024.FsymDg_0840	2.04e-94	316.0	COG2912@1|root,COG2912@2|Bacteria,2GMER@201174|Actinobacteria	201174|Actinobacteria	S	Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	TPR_9,Transglut_core2
HKD2_k127_6918765_12	710111.FraQA3DRAFT_5501	2.842e-42	159.0	COG1853@1|root,COG1853@2|Bacteria,2GMPH@201174|Actinobacteria	201174|Actinobacteria	K	PFAM flavin reductase domain protein, FMN-binding	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
HKD2_k127_6927489_0	222534.KB893670_gene3850	7.05e-119	393.0	COG0477@1|root,COG0477@2|Bacteria,2I31V@201174|Actinobacteria,4EX2D@85013|Frankiales	201174|Actinobacteria	P	TIGRFAM drug resistance transporter, EmrB QacA subfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD2_k127_6927489_2	222534.KB893715_gene1697	1.462e-97	329.0	COG0604@1|root,COG0604@2|Bacteria,2I9BF@201174|Actinobacteria,4ETNW@85013|Frankiales	201174|Actinobacteria	C	Zinc-binding dehydrogenase	-	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N,ADH_zinc_N_2
HKD2_k127_6927489_4	656024.FsymDg_1755	2.002e-06	61.0	2DCJ1@1|root,2ZEBT@2|Bacteria,2H055@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Reprolysin_4
HKD2_k127_6927489_1	1048339.KB913029_gene4317	3.765e-100	337.0	COG0846@1|root,COG0846@2|Bacteria,2GJI3@201174|Actinobacteria,4EUBM@85013|Frankiales	201174|Actinobacteria	K	Sir2 family	cobB2	-	-	ko:K12410	-	-	-	-	ko00000,ko01000	-	-	-	SIR2
HKD2_k127_6927489_3	710111.FraQA3DRAFT_0373	2.961e-27	111.0	COG0469@1|root,COG0469@2|Bacteria,2GJY8@201174|Actinobacteria,4ERSJ@85013|Frankiales	201174|Actinobacteria	G	Belongs to the pyruvate kinase family	pyk	GO:0003674,GO:0003824,GO:0004743,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016052,GO:0016053,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0040007,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PK,PK_C
HKD2_k127_6962540_6	471852.Tcur_0709	3.354e-22	97.0	COG3508@1|root,COG3508@2|Bacteria,2GKZV@201174|Actinobacteria,4EHDH@85012|Streptosporangiales	201174|Actinobacteria	Q	homogentisate 1,2-dioxygenase	-	-	1.13.11.5	ko:K00451	ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120	M00044	R02519	RC00737	ko00000,ko00001,ko00002,ko01000	-	-	-	HgmA
HKD2_k127_6962540_0	298653.Franean1_0366	9.675e-217	684.0	COG0215@1|root,COG0215@2|Bacteria,2GJF2@201174|Actinobacteria,4ERMZ@85013|Frankiales	201174|Actinobacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e
HKD2_k127_6962540_4	644283.Micau_5051	1.483e-44	180.0	COG5012@1|root,COG5012@2|Bacteria,2GKAY@201174|Actinobacteria,4DBNU@85008|Micromonosporales	201174|Actinobacteria	S	Cobalamin B12-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,B12-binding_2
HKD2_k127_6962540_1	656024.FsymDg_0407	7.207e-123	409.0	COG0566@1|root,COG0566@2|Bacteria,2GJMR@201174|Actinobacteria,4ERH3@85013|Frankiales	201174|Actinobacteria	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family	rlmB	GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070039,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.185	ko:K03218	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SpoU_methylase,SpoU_sub_bind
HKD2_k127_6962540_3	591159.ACEZ01000048_gene3019	1.843e-47	177.0	COG2050@1|root,COG2050@2|Bacteria,2IFBJ@201174|Actinobacteria	201174|Actinobacteria	Q	Domain of unknown function (DUF4442)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4442
HKD2_k127_6962540_2	1386089.N865_16535	5.877e-49	179.0	COG0589@1|root,COG0589@2|Bacteria,2IQPQ@201174|Actinobacteria	201174|Actinobacteria	T	Belongs to the universal stress protein A family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD2_k127_6962540_5	36809.MAB_4749c	3.838e-28	119.0	COG1309@1|root,COG1309@2|Bacteria,2GNQ6@201174|Actinobacteria,23B1P@1762|Mycobacteriaceae	201174|Actinobacteria	K	Bacterial transcriptional repressor C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_11,TetR_N
HKD2_k127_6964820_25	196162.Noca_0721	5.725e-05	48.0	COG1215@1|root,COG1215@2|Bacteria,2HESS@201174|Actinobacteria,4DU3S@85009|Propionibacteriales	201174|Actinobacteria	M	Glycosyl transferase family group 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3
HKD2_k127_6964820_11	1122939.ATUD01000022_gene3665	2.718e-61	234.0	COG1807@1|root,COG1807@2|Bacteria	2|Bacteria	M	4-amino-4-deoxy-L-arabinose transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	PMT,PMT_2
HKD2_k127_6964820_28	272568.GDI2511	0.0006324	48.0	COG2076@1|root,COG2076@2|Bacteria,1NAUF@1224|Proteobacteria,2UINX@28211|Alphaproteobacteria,2JYD7@204441|Rhodospirillales	204441|Rhodospirillales	P	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HKD2_k127_6964820_12	661478.OP10G_0122	1.824e-60	226.0	COG3934@1|root,COG4124@1|root,COG3934@2|Bacteria,COG4124@2|Bacteria	2|Bacteria	G	Belongs to the glycosyl hydrolase 26 family	-	-	3.1.1.53,3.2.1.78,3.2.1.81	ko:K01218,ko:K01219,ko:K05970,ko:K19355	ko00051,ko02024,map00051,map02024	-	R01332	RC00467	ko00000,ko00001,ko01000	-	GH26	-	CBM_35,Cellulase,Dockerin_1,Glyco_hydro_2_C
HKD2_k127_6964820_13	33178.CADATEAP00009780	2.278e-58	215.0	2A76J@1|root,2RYDG@2759|Eukaryota,3A0EX@33154|Opisthokonta	33154|Opisthokonta	-	-	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
HKD2_k127_6964820_7	661478.OP10G_0122	4.229e-74	267.0	COG3934@1|root,COG4124@1|root,COG3934@2|Bacteria,COG4124@2|Bacteria	2|Bacteria	G	Belongs to the glycosyl hydrolase 26 family	-	-	3.1.1.53,3.2.1.78,3.2.1.81	ko:K01218,ko:K01219,ko:K05970,ko:K19355	ko00051,ko02024,map00051,map02024	-	R01332	RC00467	ko00000,ko00001,ko01000	-	GH26	-	CBM_35,Cellulase,Dockerin_1,Glyco_hydro_2_C
HKD2_k127_6964820_26	1123321.KB905819_gene5948	0.000127	52.0	COG1011@1|root,COG1011@2|Bacteria,2GPJ4@201174|Actinobacteria	201174|Actinobacteria	S	HAD-superfamily hydrolase, subfamily IA, variant 1	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2,Hydrolase,Hydrolase_like
HKD2_k127_6964820_8	436229.JOEH01000008_gene4184	1.564e-72	248.0	COG0454@1|root,COG0456@2|Bacteria,2GNNG@201174|Actinobacteria,2NJ3S@228398|Streptacidiphilus	201174|Actinobacteria	K	Acetyltransferase (GNAT) domain	yjgM	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,MarR_2
HKD2_k127_6964820_10	1157638.KB892207_gene6712	3.879e-67	233.0	COG1309@1|root,COG1309@2|Bacteria,2I9F9@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
HKD2_k127_6964820_1	1041522.MCOL_V200355	2.442e-132	452.0	COG1289@1|root,COG1289@2|Bacteria,2GMS1@201174|Actinobacteria,2369D@1762|Mycobacteriaceae	201174|Actinobacteria	S	Fusaric acid resistance protein-like	-	-	-	-	-	-	-	-	-	-	-	-	FUSC,FUSC_2
HKD2_k127_6964820_15	644283.Micau_3511	5.106e-32	138.0	2C72U@1|root,32W8F@2|Bacteria,2GTSA@201174|Actinobacteria,4DG1X@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6964820_2	1206729.BAFZ01000160_gene6368	3.233e-120	400.0	COG2070@1|root,COG2070@2|Bacteria,2GKV4@201174|Actinobacteria,4FWIZ@85025|Nocardiaceae	201174|Actinobacteria	S	Nitronate monooxygenase	-	-	1.13.12.16	ko:K00459	ko00910,map00910	-	R00025	RC02541,RC02759	ko00000,ko00001,ko01000	-	-	-	NMO
HKD2_k127_6964820_0	1068980.ARVW01000001_gene3069	2.249e-138	454.0	COG0477@1|root,COG0477@2|Bacteria,2GIUM@201174|Actinobacteria,4E0M3@85010|Pseudonocardiales	201174|Actinobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD2_k127_6964820_5	1157637.KB892090_gene6070	3.463e-94	318.0	COG1396@1|root,COG1396@2|Bacteria,2GJXM@201174|Actinobacteria	201174|Actinobacteria	K	Helix-turn-helix domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_31
HKD2_k127_6964820_4	298655.KI912266_gene2412	6.731e-97	321.0	COG1656@1|root,COG1656@2|Bacteria,2GMQR@201174|Actinobacteria,4EV77@85013|Frankiales	201174|Actinobacteria	S	Mut7-C ubiquitin	-	-	-	ko:K09122	-	-	-	-	ko00000	-	-	-	Mut7-C,Ub-Mut7C
HKD2_k127_6964820_20	591158.SSMG_06782	7.128e-19	94.0	COG1576@1|root,COG1576@2|Bacteria,2IGAN@201174|Actinobacteria	201174|Actinobacteria	J	Mycothiol maleylpyruvate isomerase N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	MDMPI_N
HKD2_k127_6964820_16	591158.SSMG_06782	5.55e-31	124.0	COG1576@1|root,COG1576@2|Bacteria,2IGAN@201174|Actinobacteria	201174|Actinobacteria	J	Mycothiol maleylpyruvate isomerase N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	MDMPI_N
HKD2_k127_6964820_14	1173020.Cha6605_1881	2.539e-49	179.0	COG2764@1|root,COG2764@2|Bacteria,1G76J@1117|Cyanobacteria	1117|Cyanobacteria	S	Glyoxalase bleomycin resistance protein dioxygenase	-	-	-	ko:K04750	-	-	-	-	ko00000	-	-	-	3-dmu-9_3-mt
HKD2_k127_6964820_6	106370.Francci3_1980	2.942e-89	307.0	COG4325@1|root,COG4325@2|Bacteria,2GWFP@201174|Actinobacteria,4EUTU@85013|Frankiales	201174|Actinobacteria	S	Predicted membrane protein (DUF2254)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2254
HKD2_k127_6964820_24	1385518.N798_08575	6.646e-06	58.0	COG4325@1|root,COG4325@2|Bacteria,2GWFP@201174|Actinobacteria,4FGEH@85021|Intrasporangiaceae	201174|Actinobacteria	S	Predicted membrane protein (DUF2254)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2254
HKD2_k127_6964820_3	1146883.BLASA_2950	1.923e-99	332.0	COG0668@1|root,COG0668@2|Bacteria,2H4WB@201174|Actinobacteria	201174|Actinobacteria	M	Mechanosensitive ion channel	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel
HKD2_k127_6964820_21	298653.Franean1_0360	1.997e-13	81.0	COG2847@1|root,COG2847@2|Bacteria,2H1IZ@201174|Actinobacteria	201174|Actinobacteria	S	Copper chaperone PCu(A)C	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6964820_9	1206729.BAFZ01000054_gene3136	2.194e-67	246.0	COG0451@1|root,COG0451@2|Bacteria,2IIE9@201174|Actinobacteria,4G8XR@85025|Nocardiaceae	201174|Actinobacteria	GM	NAD(P)H-binding	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase,NAD_binding_10
HKD2_k127_6964820_27	1121019.AUMN01000022_gene1595	0.0003813	53.0	COG1848@1|root,COG1848@2|Bacteria,2GPX7@201174|Actinobacteria	201174|Actinobacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	GO:0008150,GO:0040008,GO:0045926,GO:0048519,GO:0050789,GO:0065007	-	ko:K07064	-	-	-	-	ko00000	-	-	-	PIN
HKD2_k127_6964820_18	1146883.BLASA_2354	4.301e-22	106.0	COG1848@1|root,COG1848@2|Bacteria,2GPX7@201174|Actinobacteria	201174|Actinobacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	GO:0008150,GO:0040008,GO:0045926,GO:0048519,GO:0050789,GO:0065007	-	ko:K07064	-	-	-	-	ko00000	-	-	-	PIN
HKD2_k127_6964820_17	656024.FsymDg_2643	1.71e-24	103.0	COG3744@1|root,COG3744@2|Bacteria,2HRGI@201174|Actinobacteria,4EWN7@85013|Frankiales	201174|Actinobacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
HKD2_k127_6995268_2	1179773.BN6_16910	3.755e-15	78.0	COG1598@1|root,COG1598@2|Bacteria,2IJK0@201174|Actinobacteria	201174|Actinobacteria	S	PFAM Uncharacterised protein family UPF0150	-	-	-	-	-	-	-	-	-	-	-	-	PHD_like
HKD2_k127_6995268_0	526225.Gobs_2302	8.419e-201	640.0	COG0366@1|root,COG0366@2|Bacteria,2GKS4@201174|Actinobacteria,4ERW2@85013|Frankiales	201174|Actinobacteria	G	SMART alpha amylase, catalytic sub domain	-	-	3.2.1.20	ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R06087,R06088	RC00028,RC00049,RC00077	ko00000,ko00001,ko01000	-	GH31	-	Alpha-amylase,DUF3459
HKD2_k127_6995268_1	1206743.BAGM01000065_gene5822	1.22e-68	259.0	COG4627@1|root,COG4627@2|Bacteria,2IHF2@201174|Actinobacteria,4G0VD@85025|Nocardiaceae	201174|Actinobacteria	S	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	BON,Methyltransf_11
HKD2_k127_7060252_2	1123320.KB889692_gene129	9.558e-17	87.0	COG0353@1|root,COG0353@2|Bacteria,2GJY0@201174|Actinobacteria	201174|Actinobacteria	L	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO	recR	-	-	ko:K06187	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	HHH,RecR,Toprim_4
HKD2_k127_7060252_1	749414.SBI_05126	8.726e-38	144.0	COG0718@1|root,COG0718@2|Bacteria,2IRC4@201174|Actinobacteria	201174|Actinobacteria	S	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection	ybaB	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K09747	-	-	-	-	ko00000	-	-	-	YbaB_DNA_bd
HKD2_k127_7060252_0	656024.FsymDg_0598	5.616e-231	732.0	COG2812@1|root,COG3170@1|root,COG2812@2|Bacteria,COG3170@2|Bacteria,2GJKA@201174|Actinobacteria,4ERVT@85013|Frankiales	201174|Actinobacteria	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity	dnaX	GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0034641,GO:0034645,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901576	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNA_pol3_gamma3
HKD2_k127_7100556_0	103733.JNYO01000008_gene5417	1.892e-273	872.0	COG2133@1|root,COG3291@1|root,COG2133@2|Bacteria,COG3291@2|Bacteria,2HEQP@201174|Actinobacteria,4DYQU@85010|Pseudonocardiales	201174|Actinobacteria	G	Repeats in polycystic kidney disease 1 (PKD1) and other proteins	-	-	-	-	-	-	-	-	-	-	-	-	GSDH
HKD2_k127_7100556_4	1068978.AMETH_4298	3.299e-05	53.0	COG1366@1|root,COG1366@2|Bacteria	2|Bacteria	T	antisigma factor binding	-	-	-	ko:K04749,ko:K06378	-	-	-	-	ko00000,ko03021	-	-	-	STAS,STAS_2
HKD2_k127_7100556_3	345341.KUTG_03684	2.672e-42	171.0	COG1309@1|root,COG1309@2|Bacteria,2GJHD@201174|Actinobacteria,4E29H@85010|Pseudonocardiales	201174|Actinobacteria	K	Bacterial transcriptional repressor C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_11,TetR_N
HKD2_k127_7100556_1	106370.Francci3_1911	5.705e-131	441.0	COG1376@1|root,COG1376@2|Bacteria,2GJBA@201174|Actinobacteria,4ESD3@85013|Frankiales	201174|Actinobacteria	S	PFAM ErfK YbiS YcfS YnhG family protein	lppS	GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0005575,GO:0005618,GO:0005623,GO:0006022,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0009273,GO:0009987,GO:0016787,GO:0017171,GO:0019538,GO:0030203,GO:0030312,GO:0042546,GO:0043170,GO:0044085,GO:0044238,GO:0044464,GO:0070008,GO:0070011,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0071972,GO:0140096,GO:1901135,GO:1901564	-	-	-	-	-	-	-	-	-	-	YkuD
HKD2_k127_7100556_2	644283.Micau_2811	1.171e-59	210.0	COG1804@1|root,COG1804@2|Bacteria,2GKNX@201174|Actinobacteria,4D8P5@85008|Micromonosporales	201174|Actinobacteria	C	L-carnitine dehydratase bile acid-inducible protein F	-	-	5.1.99.4	ko:K01796	ko00120,ko01100,ko04146,map00120,map01100,map04146	M00104	R08734,R08739	RC02345	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_transf_3
HKD2_k127_7128186_2	882082.SaccyDRAFT_0678	1.102e-49	182.0	COG3324@1|root,COG3324@2|Bacteria,2GJFC@201174|Actinobacteria,4E3XB@85010|Pseudonocardiales	201174|Actinobacteria	S	Glyoxalase bleomycin resistance protein dioxygenase	-	-	-	ko:K06996	-	-	-	-	ko00000	-	-	-	Glyoxalase
HKD2_k127_7128186_1	1137269.AZWL01000001_gene5573	1.525e-74	282.0	COG3568@1|root,COG3568@2|Bacteria,2IGGC@201174|Actinobacteria	201174|Actinobacteria	S	Endonuclease/Exonuclease/phosphatase family	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
HKD2_k127_7128186_0	2074.JNYD01000013_gene6933	9.304e-154	495.0	COG3842@1|root,COG3842@2|Bacteria,2GJCM@201174|Actinobacteria,4E0UU@85010|Pseudonocardiales	201174|Actinobacteria	E	ABC transporter	-	-	-	ko:K10112	ko02010,map02010	M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1	-	-	ABC_tran,TOBE_2
HKD2_k127_715787_3	1056816.JAFQ01000004_gene4885	6.665e-65	225.0	COG5285@1|root,COG5285@2|Bacteria	2|Bacteria	Q	dioxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,PhyH
HKD2_k127_715787_4	1056816.JAFQ01000004_gene4885	6.004e-34	132.0	COG5285@1|root,COG5285@2|Bacteria	2|Bacteria	Q	dioxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,PhyH
HKD2_k127_715787_0	1380347.JNII01000005_gene2893	6.752e-258	872.0	COG0642@1|root,COG0745@1|root,COG2203@1|root,COG2208@1|root,COG0745@2|Bacteria,COG2203@2|Bacteria,COG2205@2|Bacteria,COG2208@2|Bacteria,2GK8P@201174|Actinobacteria,4ERBM@85013|Frankiales	201174|Actinobacteria	T	protein phosphatase 2C domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HATPase_c_2,HisKA,PAS_3,PAS_4,Response_reg,STAS_2,SpoIIE
HKD2_k127_715787_2	656024.FsymDg_1221	8.441e-98	351.0	COG0566@1|root,COG0566@2|Bacteria,2GJ12@201174|Actinobacteria,4ESMS@85013|Frankiales	201174|Actinobacteria	J	PFAM tRNA rRNA methyltransferase, SpoU	spoU2	-	-	-	-	-	-	-	-	-	-	-	SpoU_methylase
HKD2_k127_715787_1	1136417.AZWE01000061_gene843	4.549e-107	358.0	COG0859@1|root,COG0859@2|Bacteria,2GMWP@201174|Actinobacteria,4DBX9@85008|Micromonosporales	201174|Actinobacteria	M	transferase family	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_9
HKD2_k127_720744_6	1122611.KB904018_gene7012	0.0004362	43.0	COG1366@1|root,COG1366@2|Bacteria,2IKVE@201174|Actinobacteria,4EJGN@85012|Streptosporangiales	201174|Actinobacteria	T	STAS domain	rsbS	-	-	ko:K17762	-	-	-	-	ko00000,ko03021	-	-	-	STAS,STAS_2
HKD2_k127_720744_3	935839.JAGJ01000014_gene3577	5.665e-47	174.0	COG2172@1|root,COG2172@2|Bacteria,2IKM9@201174|Actinobacteria	201174|Actinobacteria	T	anti-sigma regulatory factor	rsbT	-	2.7.11.1	ko:K17752	-	-	-	-	ko00000,ko01000,ko01001,ko03021	-	-	-	HATPase_c,HATPase_c_2,Sigma70_r2
HKD2_k127_720744_1	1120936.KB907211_gene370	3.505e-89	312.0	COG2172@1|root,COG2208@1|root,COG2172@2|Bacteria,COG2208@2|Bacteria,2I4DN@201174|Actinobacteria,4EFH1@85012|Streptosporangiales	201174|Actinobacteria	KT	Sigma factor PP2C-like phosphatases	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c_2,SpoIIE
HKD2_k127_720744_0	326424.FRAAL1279	6.19e-140	467.0	COG0642@1|root,COG2205@2|Bacteria,2I2M2@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg
HKD2_k127_720744_4	134676.ACPL_379	1.618e-46	193.0	COG0745@1|root,COG2208@1|root,COG0745@2|Bacteria,COG2208@2|Bacteria,2GS3I@201174|Actinobacteria,4D9X0@85008|Micromonosporales	201174|Actinobacteria	T	Sigma factor PP2C-like phosphatases	prpG2	-	-	-	-	-	-	-	-	-	-	-	Response_reg,SpoIIE
HKD2_k127_720744_2	33876.JNXY01000015_gene7454	8.795e-57	226.0	COG2208@1|root,COG2208@2|Bacteria,2GKN8@201174|Actinobacteria,4DAEE@85008|Micromonosporales	201174|Actinobacteria	T	Stage II sporulation	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,SpoIIE
HKD2_k127_720744_5	526225.Gobs_3532	3.292e-16	78.0	COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,2GJQI@201174|Actinobacteria,4ERUS@85013|Frankiales	201174|Actinobacteria	L	manually curated	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_28,HTH_29,HTH_32
HKD2_k127_7242146_3	365528.KB891218_gene1535	1.208e-92	310.0	COG0072@1|root,COG0073@1|root,COG0072@2|Bacteria,COG0073@2|Bacteria,2GMFD@201174|Actinobacteria,4ES8F@85013|Frankiales	201174|Actinobacteria	J	phenylalanyl-tRNA synthetase beta subunit	pheT	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0019538,GO:0019752,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,tRNA_bind
HKD2_k127_7242146_1	656024.FsymDg_3278	6.504e-155	499.0	COG0002@1|root,COG0002@2|Bacteria,2GKQK@201174|Actinobacteria,4ES9C@85013|Frankiales	201174|Actinobacteria	E	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde	argC	GO:0000166,GO:0003674,GO:0005488,GO:0008150,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0048037,GO:0050661,GO:0050662,GO:0070401,GO:0097159,GO:1901265,GO:1901363	1.2.1.38	ko:K00145	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R03443	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
HKD2_k127_7242146_0	656024.FsymDg_3277	7.536e-167	547.0	COG1364@1|root,COG1364@2|Bacteria,2GIW0@201174|Actinobacteria,4ES7A@85013|Frankiales	201174|Actinobacteria	E	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate	argJ	GO:0003674,GO:0003824,GO:0004042,GO:0004358,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006592,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.3.1.1,2.3.1.35	ko:K00620	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259,R02282	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	ArgJ
HKD2_k127_7242146_2	656024.FsymDg_3276	1.296e-110	374.0	COG0548@1|root,COG0548@2|Bacteria,2GKDS@201174|Actinobacteria,4ERTB@85013|Frankiales	201174|Actinobacteria	E	Belongs to the acetylglutamate kinase family. ArgB subfamily	argB	GO:0003674,GO:0003824,GO:0003991,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016020,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0019752,GO:0030312,GO:0031406,GO:0034618,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.2.8	ko:K00930	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R02649	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase
HKD2_k127_7244454_11	222534.KB893715_gene1693	1.206e-05	47.0	COG5421@1|root,COG5421@2|Bacteria,2GK2A@201174|Actinobacteria	201174|Actinobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
HKD2_k127_7244454_1	369723.Strop_3591	7.245e-172	552.0	COG1070@1|root,COG1070@2|Bacteria,2GJDZ@201174|Actinobacteria,4D9ZD@85008|Micromonosporales	201174|Actinobacteria	G	Xylulose kinase	xylB	-	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
HKD2_k127_7244454_0	656024.FsymDg_1299	5.4e-284	890.0	COG0753@1|root,COG0753@2|Bacteria,2GITN@201174|Actinobacteria,4ES38@85013|Frankiales	201174|Actinobacteria	C	Catalase	katA	-	1.11.1.6	ko:K03781	ko00380,ko00630,ko01110,ko01130,ko01200,ko04011,ko04016,ko04068,ko04146,ko04211,ko04212,ko04213,ko05014,map00380,map00630,map01110,map01130,map01200,map04011,map04016,map04068,map04146,map04211,map04212,map04213,map05014	M00532	R00009,R00602,R02670	RC00034,RC00767,RC02141,RC02755	ko00000,ko00001,ko00002,ko01000	-	-	-	Catalase,Catalase-rel
HKD2_k127_7244454_6	656024.FsymDg_1298	5.813e-59	209.0	COG0735@1|root,COG0735@2|Bacteria,2IFBR@201174|Actinobacteria,4ESW1@85013|Frankiales	201174|Actinobacteria	P	Belongs to the Fur family	-	-	-	ko:K03711,ko:K22297	-	-	-	-	ko00000,ko03000	-	-	-	FUR
HKD2_k127_7244454_10	1463857.JOFZ01000001_gene6006	7.194e-13	79.0	COG2002@1|root,COG2002@2|Bacteria,2GUD2@201174|Actinobacteria	201174|Actinobacteria	K	toxin-antitoxin pair type II binding	-	-	-	-	-	-	-	-	-	-	-	-	MazE_antitoxin
HKD2_k127_7244454_3	326424.FRAAL1530	1.81e-74	254.0	COG0406@1|root,COG0406@2|Bacteria,2GNRS@201174|Actinobacteria,4EVNT@85013|Frankiales	201174|Actinobacteria	G	phosphoglycerate mutase	gpm2	GO:0003674,GO:0003824,GO:0003993,GO:0005488,GO:0005515,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0042578,GO:0042802,GO:0042803,GO:0044237,GO:0046983	3.1.3.73	ko:K02226	ko00860,ko01100,map00860,map01100	M00122	R04594,R11173	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	His_Phos_1
HKD2_k127_7244454_5	313589.JNB_13828	9.588e-66	229.0	COG2343@1|root,COG2343@2|Bacteria,2IKUM@201174|Actinobacteria,4FGD7@85021|Intrasporangiaceae	201174|Actinobacteria	S	Domain of unknown function (DUF427)	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_9
HKD2_k127_7244454_9	298653.Franean1_5630	8.442e-22	101.0	2DR8N@1|root,33APF@2|Bacteria,2GT2M@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF3618)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3618
HKD2_k127_7244454_4	656024.FsymDg_1547	1.517e-67	239.0	COG1999@1|root,COG1999@2|Bacteria,2GKF0@201174|Actinobacteria	201174|Actinobacteria	S	SCO1 SenC	-	-	-	ko:K07152	-	-	-	-	ko00000,ko03029	-	-	-	SCO1-SenC
HKD2_k127_7244454_7	298653.Franean1_5633	9.006e-51	190.0	COG2259@1|root,COG2259@2|Bacteria,2IQEY@201174|Actinobacteria,4ETDJ@85013|Frankiales	201174|Actinobacteria	O	Methylamine utilisation protein MauE	-	-	-	-	-	-	-	-	-	-	-	-	DoxX,MauE
HKD2_k127_7244454_8	106370.Francci3_0913	2.065e-48	185.0	COG1651@1|root,COG1651@2|Bacteria,2GN3N@201174|Actinobacteria,4EX1Z@85013|Frankiales	201174|Actinobacteria	O	Thioredoxin	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_4
HKD2_k127_7244454_2	351607.Acel_2052	1.917e-84	290.0	COG0215@1|root,COG4242@1|root,COG0215@2|Bacteria,COG4242@2|Bacteria,2I98G@201174|Actinobacteria	201174|Actinobacteria	J	Belongs to the peptidase S51 family	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7270909_0	1121272.KB903261_gene5983	1.217e-129	449.0	COG5001@1|root,COG5001@2|Bacteria,2GIZF@201174|Actinobacteria,4DGRI@85008|Micromonosporales	201174|Actinobacteria	T	Putative diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF
HKD2_k127_7270983_6	1064537.AGSO01000001_gene745	4e-15	81.0	COG1376@1|root,COG3409@1|root,COG1376@2|Bacteria,COG3409@2|Bacteria,2GXGF@201174|Actinobacteria,4FCDY@85020|Dermabacteraceae	201174|Actinobacteria	M	L,D-transpeptidase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_1,YkuD
HKD2_k127_7270983_4	1122138.AQUZ01000065_gene4248	3.625e-42	166.0	COG0500@1|root,COG2226@2|Bacteria,2II6W@201174|Actinobacteria,4DVHR@85009|Propionibacteriales	201174|Actinobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_23
HKD2_k127_7270983_1	211114.JOEF01000037_gene6876	1.616e-112	388.0	COG0715@1|root,COG0715@2|Bacteria,2I95I@201174|Actinobacteria,4E1JF@85010|Pseudonocardiales	201174|Actinobacteria	P	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7270983_5	710111.FraQA3DRAFT_0589	1.183e-33	149.0	COG0683@1|root,COG0683@2|Bacteria,2IEFV@201174|Actinobacteria	201174|Actinobacteria	E	ABC-type branched-chain amino acid transport	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
HKD2_k127_7270983_8	710111.FraQA3DRAFT_5647	0.0002673	53.0	COG1396@1|root,COG1396@2|Bacteria,2I3J1@201174|Actinobacteria	201174|Actinobacteria	K	sequence-specific DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7270983_0	106370.Francci3_1022	7.621e-120	400.0	COG5606@1|root,COG5606@2|Bacteria,2I56B@201174|Actinobacteria	201174|Actinobacteria	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7270983_2	298653.Franean1_6315	4.527e-98	325.0	COG1514@1|root,COG1514@2|Bacteria,2IFYV@201174|Actinobacteria	201174|Actinobacteria	J	2'-5' RNA ligase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	2_5_RNA_ligase2
HKD2_k127_7270983_3	479434.Sthe_1357	2.516e-82	282.0	COG1506@1|root,COG1506@2|Bacteria,2G5NN@200795|Chloroflexi,27YSI@189775|Thermomicrobia	189775|Thermomicrobia	E	Dienelactone hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
HKD2_k127_7305982_2	298653.Franean1_2035	3.013e-100	334.0	COG3707@1|root,COG3707@2|Bacteria,2GK7T@201174|Actinobacteria,4ESDD@85013|Frankiales	201174|Actinobacteria	T	Response regulator receiver	pdtaR	GO:0000160,GO:0003674,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0007154,GO:0007165,GO:0008150,GO:0009987,GO:0016020,GO:0023052,GO:0030312,GO:0035556,GO:0040007,GO:0043167,GO:0043168,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0071944	-	ko:K22010	-	M00839	-	-	ko00000,ko00002,ko02022	-	-	-	ANTAR,Response_reg
HKD2_k127_7305982_5	1229780.BN381_350140	1.081e-18	95.0	COG2161@1|root,COG2161@2|Bacteria,2GV08@201174|Actinobacteria	201174|Actinobacteria	D	Antitoxin component of a toxin-antitoxin (TA) module	relB	GO:0003674,GO:0005488,GO:0005515,GO:0008150,GO:0040008,GO:0045927,GO:0048518,GO:0050789,GO:0065007,GO:0097351	-	ko:K19159	-	-	-	-	ko00000,ko02048	-	-	-	PhdYeFM_antitox
HKD2_k127_7305982_4	1122622.ATWJ01000010_gene1302	6.036e-25	112.0	COG2026@1|root,COG2026@2|Bacteria,2GRQR@201174|Actinobacteria,4FHYW@85021|Intrasporangiaceae	201174|Actinobacteria	DJ	ParE toxin of type II toxin-antitoxin system, parDE	relE	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0019439,GO:0034641,GO:0034655,GO:0040008,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0045926,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0065007,GO:0071704,GO:0090304,GO:0090305,GO:1901360,GO:1901361,GO:1901575	-	-	-	-	-	-	-	-	-	-	ParE_toxin
HKD2_k127_7305982_1	326424.FRAAL4964	4.717e-264	821.0	COG0493@1|root,COG0493@2|Bacteria,2GJ0A@201174|Actinobacteria,4ERK8@85013|Frankiales	201174|Actinobacteria	C	TIGRFAM glutamate synthase, NADH NADPH, small subunit	gltD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	iNJ661.Rv3858c	Fer4_20,Pyr_redox_2
HKD2_k127_7305982_0	351607.Acel_1078	0.0	2265.0	COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,2GN09@201174|Actinobacteria,4ERS2@85013|Frankiales	201174|Actinobacteria	E	Glutamate synthase	gltB	-	1.4.1.13,1.4.1.14	ko:K00265	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
HKD2_k127_7305982_3	298653.Franean1_0219	5.465e-46	172.0	COG2340@1|root,COG2340@2|Bacteria,2GM57@201174|Actinobacteria,4EWAF@85013|Frankiales	201174|Actinobacteria	S	Cysteine-rich secretory protein family	-	-	-	-	-	-	-	-	-	-	-	-	CAP
HKD2_k127_7311356_1	656024.FsymDg_3198	1.766e-212	665.0	COG0379@1|root,COG0379@2|Bacteria,2GM59@201174|Actinobacteria,4ESYU@85013|Frankiales	201174|Actinobacteria	H	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate	nadA	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008987,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016053,GO:0017144,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0019805,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046496,GO:0046874,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	2.5.1.72	ko:K03517	ko00760,ko01100,map00760,map01100	M00115	R04292	RC01119	ko00000,ko00001,ko00002,ko01000	-	-	-	NadA
HKD2_k127_7311356_8	656024.FsymDg_3199	1.535e-66	233.0	2AN86@1|root,31D67@2|Bacteria,2HWWU@201174|Actinobacteria,4ETBI@85013|Frankiales	201174|Actinobacteria	S	Protein of unknown function (DUF3043)	-	GO:0008150,GO:0009605,GO:0009607,GO:0020012,GO:0030682,GO:0042783,GO:0043207,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051805,GO:0051807,GO:0051810,GO:0051832,GO:0051834,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0075136	-	-	-	-	-	-	-	-	-	-	DUF3043
HKD2_k127_7311356_2	351607.Acel_0948	3.58e-160	510.0	COG0667@1|root,COG0667@2|Bacteria,2GMT5@201174|Actinobacteria,4ERBY@85013|Frankiales	201174|Actinobacteria	C	PFAM aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
HKD2_k127_7311356_13	44060.JODL01000024_gene226	2.19e-21	98.0	2EFWK@1|root,339NW@2|Bacteria,2IQXQ@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7311356_11	1229780.BN381_70079	6.016e-46	183.0	COG1404@1|root,COG1657@1|root,COG1404@2|Bacteria,COG1657@2|Bacteria	2|Bacteria	I	PFAM Prenyltransferase squalene oxidase	-	-	-	-	-	-	-	-	-	-	-	-	B_lectin,Big_3_2,Flg_new,PKD,RCC1,RCC1_2,SLH
HKD2_k127_7311356_5	1120950.KB892707_gene4769	2.854e-131	439.0	COG0619@1|root,COG0619@2|Bacteria,2GKHK@201174|Actinobacteria,4DPHW@85009|Propionibacteriales	201174|Actinobacteria	P	Cobalt transport protein	ecfT	-	-	ko:K16785	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	CbiQ
HKD2_k127_7311356_0	1223523.H340_27865	2.633e-213	689.0	COG3845@1|root,COG3845@2|Bacteria,2I2Y2@201174|Actinobacteria	201174|Actinobacteria	P	ABC transporter, ATP-binding protein	-	-	-	ko:K16786,ko:K16787	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	ABC_tran
HKD2_k127_7311356_6	367299.JOEE01000003_gene2743	1.405e-88	321.0	COG1122@1|root,COG1122@2|Bacteria,2GMK1@201174|Actinobacteria,4FF62@85021|Intrasporangiaceae	201174|Actinobacteria	P	ABC transporter (Permease)	-	-	-	ko:K16927	-	M00582	-	-	ko00000,ko00002,ko02000	3.A.1.32	-	-	ECF_trnsprt
HKD2_k127_7311356_3	326424.FRAAL5138	8.362e-157	532.0	COG1235@1|root,COG2087@1|root,COG1235@2|Bacteria,COG2087@2|Bacteria,2GM8Q@201174|Actinobacteria,4EVGH@85013|Frankiales	201174|Actinobacteria	H	Cobinamide kinase / cobinamide phosphate guanyltransferase	cobU	-	2.7.1.156,2.7.7.62	ko:K02231	ko00860,ko01100,map00860,map01100	M00122	R05221,R05222,R06558	RC00002,RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	CobU,Lactamase_B_2
HKD2_k127_7311356_10	326424.FRAAL0476	5.98e-49	189.0	COG1670@1|root,COG1670@2|Bacteria	2|Bacteria	J	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
HKD2_k127_7311356_9	710111.FraQA3DRAFT_6477	8.695e-65	243.0	2CKXR@1|root,32SD7@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7311356_4	710111.FraQA3DRAFT_6384	2.779e-147	473.0	COG2038@1|root,COG2038@2|Bacteria,2GJ16@201174|Actinobacteria,4ERJF@85013|Frankiales	201174|Actinobacteria	H	Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB)	cobT	-	2.4.2.21	ko:K00768	ko00860,ko01100,map00860,map01100	M00122	R04148	RC00033,RC00063	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv2207	CobU,DBI_PRT
HKD2_k127_7311356_7	298653.Franean1_1783	8.811e-67	244.0	COG0368@1|root,COG0368@2|Bacteria,2GKM4@201174|Actinobacteria,4ET2Y@85013|Frankiales	201174|Actinobacteria	H	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate	cobS	-	2.7.8.26	ko:K02233	ko00860,ko01100,map00860,map01100	M00122	R05223,R11174	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	CobS
HKD2_k127_7311356_12	351607.Acel_0938	3.468e-35	141.0	COG0703@1|root,COG0703@2|Bacteria,2IQZ8@201174|Actinobacteria,4EW56@85013|Frankiales	201174|Actinobacteria	F	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate	-	-	2.7.1.71	ko:K00891	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	SKI
HKD2_k127_7315625_0	675635.Psed_1620	3.349e-54	198.0	2DBFP@1|root,2Z8ZG@2|Bacteria,2IAVA@201174|Actinobacteria,4EAS9@85010|Pseudonocardiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7315625_1	222534.KB893683_gene1170	3.819e-32	139.0	COG0515@1|root,COG2319@1|root,COG0515@2|Bacteria,COG2319@2|Bacteria,2GIV0@201174|Actinobacteria,4EX1X@85013|Frankiales	201174|Actinobacteria	KLT	Serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase,WD40
HKD2_k127_7333376_7	1155718.KB891855_gene91	9.409e-26	118.0	COG0500@1|root,COG0500@2|Bacteria,2GKYW@201174|Actinobacteria	201174|Actinobacteria	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase_4,Methyltransf_11,NUDIX
HKD2_k127_7333376_4	1121017.AUFG01000024_gene2104	6.297e-35	138.0	COG0254@1|root,COG0254@2|Bacteria,2IQ4I@201174|Actinobacteria	201174|Actinobacteria	J	50S ribosomal protein L31	rpmE2	-	-	ko:K02909	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L31
HKD2_k127_7333376_1	656024.FsymDg_4208	3.028e-110	373.0	COG0803@1|root,COG0803@2|Bacteria,2GM1K@201174|Actinobacteria,4ET8X@85013|Frankiales	201174|Actinobacteria	P	Belongs to the bacterial solute-binding protein 9 family	yfeA	-	-	ko:K02077,ko:K09815,ko:K09818	ko02010,map02010	M00242,M00243,M00244	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15,3.A.1.15.3,3.A.1.15.5	-	-	ZnuA
HKD2_k127_7333376_0	656024.FsymDg_4207	4.675e-114	375.0	COG1121@1|root,COG1121@2|Bacteria,2GN95@201174|Actinobacteria,4ET4X@85013|Frankiales	201174|Actinobacteria	P	pfam abc	yfeB	-	-	ko:K02074,ko:K09820,ko:K11710	ko02010,map02010	M00243,M00244,M00319	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15	-	-	ABC_tran
HKD2_k127_7333376_2	656024.FsymDg_4206	6.656e-106	356.0	COG1108@1|root,COG1108@2|Bacteria,2GJ7H@201174|Actinobacteria,4ETAC@85013|Frankiales	201174|Actinobacteria	P	PFAM ABC-3 protein	yfeC	-	-	ko:K02075,ko:K09816,ko:K09819	ko02010,map02010	M00242,M00243,M00244	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15,3.A.1.15.3,3.A.1.15.5	-	-	ABC-3
HKD2_k127_7333376_3	656024.FsymDg_4205	1.595e-87	311.0	COG1108@1|root,COG1108@2|Bacteria,2IGW9@201174|Actinobacteria,4EXA0@85013|Frankiales	201174|Actinobacteria	P	ABC 3 transport family	yfeD	-	-	ko:K02075,ko:K09819	-	M00243,M00244	-	-	ko00000,ko00002,ko02000	3.A.1.15	-	-	ABC-3
HKD2_k127_7333376_5	263358.VAB18032_28236	8.238e-34	132.0	COG0640@1|root,COG0640@2|Bacteria,2IMSD@201174|Actinobacteria,4DF3A@85008|Micromonosporales	201174|Actinobacteria	K	transcriptional	smtB	GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0010035,GO:0010038,GO:0010043,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0042221,GO:0044212,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141	-	ko:K22298	-	-	-	-	ko00000,ko03000	-	-	-	HTH_5
HKD2_k127_7333376_6	1134445.AJJM01000139_gene1208	6.242e-33	146.0	COG1108@1|root,COG1108@2|Bacteria,2IQV2@201174|Actinobacteria	201174|Actinobacteria	P	ABC-type Mn2 Zn2 transport systems permease components	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7341286_1	298655.KI912267_gene7069	1.698e-48	179.0	COG1835@1|root,COG2755@1|root,COG1835@2|Bacteria,COG2755@2|Bacteria,2GKI5@201174|Actinobacteria	201174|Actinobacteria	I	Acyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
HKD2_k127_7341286_0	118173.KB235914_gene1903	4.611e-172	563.0	COG1089@1|root,COG1089@2|Bacteria,1G0M4@1117|Cyanobacteria,1H6XT@1150|Oscillatoriales	1117|Cyanobacteria	M	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose	gmd	-	4.2.1.47	ko:K01711	ko00051,ko00520,ko01100,map00051,map00520,map01100	-	R00888	RC00402	ko00000,ko00001,ko01000	-	-	-	GDP_Man_Dehyd
HKD2_k127_7341286_2	298655.KI912267_gene7072	5.226e-46	171.0	COG2244@1|root,COG2244@2|Bacteria,2IAQ4@201174|Actinobacteria	201174|Actinobacteria	S	polysaccharide biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7540770_1	710111.FraQA3DRAFT_3945	3.7e-65	229.0	COG1427@1|root,COG1427@2|Bacteria,2GJGY@201174|Actinobacteria	201174|Actinobacteria	S	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)	mqnA	-	4.2.1.151	ko:K11782	ko00130,ko01110,map00130,map01110	-	R10666	RC03232	ko00000,ko00001,ko01000	-	-	-	VitK2_biosynth
HKD2_k127_7540770_0	1122138.AQUZ01000067_gene4297	2.513e-78	280.0	COG1075@1|root,COG1075@2|Bacteria,2GMZA@201174|Actinobacteria,4DSKT@85009|Propionibacteriales	201174|Actinobacteria	S	Lecithin:cholesterol acyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,DUF676
HKD2_k127_7540770_2	487521.OCU_35700	2.275e-20	99.0	COG0204@1|root,COG0204@2|Bacteria,2GNBB@201174|Actinobacteria,23691@1762|Mycobacteriaceae	201174|Actinobacteria	I	Acyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acyltransferase
HKD2_k127_7543113_3	675635.Psed_4773	5.876e-11	71.0	COG0227@1|root,COG0227@2|Bacteria,2GQNU@201174|Actinobacteria	201174|Actinobacteria	J	Belongs to the bacterial ribosomal protein bL28 family	rpmB	GO:0003674,GO:0003735,GO:0005198	-	ko:K02902	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L28
HKD2_k127_7543113_1	219305.MCAG_04240	1.024e-35	153.0	COG1461@1|root,COG1461@2|Bacteria,2GKII@201174|Actinobacteria,4D8DT@85008|Micromonosporales	201174|Actinobacteria	S	Dak phosphatase	dak3	-	-	ko:K07030	-	-	-	-	ko00000	-	-	-	Dak1_2,Dak2
HKD2_k127_7543113_2	298653.Franean1_1131	5.761e-33	130.0	COG0227@1|root,COG0227@2|Bacteria,2GQNU@201174|Actinobacteria,4ETC7@85013|Frankiales	201174|Actinobacteria	J	Belongs to the bacterial ribosomal protein bL28 family	rpmB	GO:0003674,GO:0003735,GO:0005198	-	ko:K02902	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L28
HKD2_k127_7543113_0	745776.DGo_CA0887	5.05e-57	205.0	COG0366@1|root,COG0366@2|Bacteria,1WIXP@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	G	PFAM alpha amylase, catalytic	-	-	2.4.1.4	ko:K05341	ko00500,map00500	-	R01823	RC00028	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase
HKD2_k127_7591590_1	1254432.SCE1572_26520	9.949e-26	110.0	COG4634@1|root,COG4634@2|Bacteria,1RH7A@1224|Proteobacteria,42Y3E@68525|delta/epsilon subdivisions,2WSPC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Mut7-C
HKD2_k127_7591590_2	1121019.AUMN01000020_gene1686	6.061e-23	100.0	COG2442@1|root,COG2442@2|Bacteria,2GQK1@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF433)	-	-	-	-	-	-	-	-	-	-	-	-	DUF433
HKD2_k127_7591590_0	1449976.KALB_4417	8.683e-33	128.0	COG1607@1|root,COG1607@2|Bacteria,2IKM2@201174|Actinobacteria,4E3PP@85010|Pseudonocardiales	201174|Actinobacteria	I	Thioesterase superfamily	-	-	4.3.1.14	ko:K18014	ko00310,map00310	-	R03030	RC00833	ko00000,ko00001,ko01000	-	-	-	4HBT
HKD2_k127_7644050_11	1123060.JONP01000065_gene8	0.0005304	52.0	COG1714@1|root,COG1714@2|Bacteria,1MZAD@1224|Proteobacteria,2UM11@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	RDD family	-	-	-	-	-	-	-	-	-	-	-	-	RDD
HKD2_k127_7644050_2	1283299.AUKG01000002_gene5291	3.663e-70	250.0	COG0604@1|root,COG0604@2|Bacteria,2I8KK@201174|Actinobacteria,4CS3W@84995|Rubrobacteria	84995|Rubrobacteria	C	Zinc-binding dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7644050_3	656024.FsymDg_3594	2.296e-63	239.0	COG2203@1|root,COG2208@1|root,COG2203@2|Bacteria,COG2208@2|Bacteria,2GK8P@201174|Actinobacteria	201174|Actinobacteria	T	protein phosphatase 2C domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c_2,PAS_3,PAS_4,SpoIIE
HKD2_k127_7644050_9	28444.JODQ01000006_gene23	1.248e-21	110.0	2EPAY@1|root,33GXQ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7644050_7	479432.Sros_8658	1.44e-25	109.0	2ERM1@1|root,33J6I@2|Bacteria,2GYP1@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF3883
HKD2_k127_7644050_0	1463841.JOIR01000045_gene1982	2.283e-90	304.0	COG3467@1|root,COG3467@2|Bacteria,2IAMC@201174|Actinobacteria	201174|Actinobacteria	S	pyridoxamine 5-phosphate	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
HKD2_k127_7644050_8	326424.FRAAL6626	3.06e-23	106.0	COG0524@1|root,COG0524@2|Bacteria,2I04R@201174|Actinobacteria	201174|Actinobacteria	G	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway	rbsK	-	2.7.1.15	ko:K00852	ko00030,map00030	-	R01051,R02750	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
HKD2_k127_7644050_5	222534.KB893763_gene24	2.157e-32	138.0	COG0524@1|root,COG0524@2|Bacteria,2I04R@201174|Actinobacteria	201174|Actinobacteria	G	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway	rbsK	-	2.7.1.15	ko:K00852	ko00030,map00030	-	R01051,R02750	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
HKD2_k127_7644050_4	222534.KB893763_gene23	5.922e-60	216.0	COG0242@1|root,COG0242@2|Bacteria,2GJT4@201174|Actinobacteria	201174|Actinobacteria	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions	-	-	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	HTH_31,Pep_deformylase
HKD2_k127_7644050_10	1463934.JOCF01000010_gene4620	1.56e-21	109.0	COG0242@1|root,COG0242@2|Bacteria	2|Bacteria	J	peptide deformylase activity	-	-	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	HTH_31,Pep_deformylase
HKD2_k127_7644050_1	710111.FraQA3DRAFT_5209	3.033e-90	304.0	COG0242@1|root,COG0242@2|Bacteria,2GJT4@201174|Actinobacteria	201174|Actinobacteria	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions	-	-	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	HTH_31,Pep_deformylase
HKD2_k127_7644050_6	656024.FsymDg_1287	3.918e-28	126.0	COG3355@1|root,COG3355@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	EIIA-man,HTH_36,PAS_4,PRD,ROK,Sigma54_activat
HKD2_k127_7670024_5	596328.HMPREF0578_0730	4.711e-28	120.0	COG1470@1|root,COG1470@2|Bacteria,2GP8D@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF3048) C-terminal domain	yerB	-	-	-	-	-	-	-	-	-	-	-	DUF3048,DUF3048_C
HKD2_k127_7670024_1	1146883.BLASA_1780	8.936e-118	402.0	COG0745@1|root,COG2198@1|root,COG2199@1|root,COG0745@2|Bacteria,COG2198@2|Bacteria,COG3706@2|Bacteria	2|Bacteria	T	GGDEF domain	rcsD	GO:0000160,GO:0003674,GO:0003824,GO:0004672,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009927,GO:0009987,GO:0016020,GO:0016021,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019538,GO:0023052,GO:0031224,GO:0031226,GO:0035556,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0060089,GO:0065007,GO:0071704,GO:0071944,GO:0140096,GO:1901564	2.7.13.3,2.7.7.65,4.6.1.1	ko:K01768,ko:K02488,ko:K07676,ko:K10715,ko:K20976	ko00230,ko02020,ko02024,ko02025,ko02026,ko04112,ko04113,ko04213,map00230,map02020,map02024,map02025,map02026,map04112,map04113,map04213	M00474,M00511,M00517,M00695,M00820	R00089,R00434,R08057	RC00295	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	GGDEF,HATPase_c,HisKA,Hpt,RcsD_ABL,Response_reg,Trans_reg_C
HKD2_k127_7670024_2	1449069.JMLO01000016_gene3394	7.248e-44	173.0	COG0748@1|root,COG0748@2|Bacteria,2IFYD@201174|Actinobacteria,4G9EE@85025|Nocardiaceae	201174|Actinobacteria	P	F420H(2)-dependent quinone reductase	-	-	-	-	-	-	-	-	-	-	-	-	F420H2_quin_red
HKD2_k127_7670024_3	47763.JNZA01000028_gene6197	2.721e-35	148.0	COG0517@1|root,COG0517@2|Bacteria	2|Bacteria	S	IMP dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	CBS
HKD2_k127_7670024_0	28042.GU90_06060	2.822e-160	518.0	COG2733@1|root,COG2733@2|Bacteria,2GKGM@201174|Actinobacteria,4DYTZ@85010|Pseudonocardiales	201174|Actinobacteria	S	Protein of unknown function (DUF445)	-	-	-	-	-	-	-	-	-	-	-	-	DUF445
HKD2_k127_7670024_6	710111.FraQA3DRAFT_1037	1.401e-12	81.0	2E62U@1|root,330RX@2|Bacteria,2GTSM@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7670024_4	1223523.H340_02684	6.68e-30	121.0	COG3305@1|root,COG3305@2|Bacteria,2GNU5@201174|Actinobacteria	201174|Actinobacteria	S	Predicted membrane protein (DUF2127)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2127
HKD2_k127_7681415_9	326424.FRAAL5254	9.892e-37	141.0	COG4768@1|root,COG4768@2|Bacteria,2II1J@201174|Actinobacteria,4ET7N@85013|Frankiales	201174|Actinobacteria	S	Bacterial protein of unknown function (DUF948)	-	-	-	-	-	-	-	-	-	-	-	-	DUF948
HKD2_k127_7681415_12	298655.KI912266_gene5813	6.424e-14	77.0	2DYUN@1|root,34B61@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7681415_10	1463887.KL589967_gene6717	5.992e-35	141.0	COG1848@1|root,COG1848@2|Bacteria,2IJ8I@201174|Actinobacteria	201174|Actinobacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	-	-	-	-	-	-	-	-	-	PIN
HKD2_k127_7681415_13	1463881.KL591002_gene4830	4.722e-10	64.0	2AZGH@1|root,31RQI@2|Bacteria,2GPQK@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF1778
HKD2_k127_7681415_3	365528.KB891218_gene1492	2.116e-193	622.0	COG2256@1|root,COG2256@2|Bacteria,2GKDP@201174|Actinobacteria,4ERXK@85013|Frankiales	201174|Actinobacteria	L	AAA ATPase, central domain protein	rarA	-	-	ko:K07478	-	-	-	-	ko00000	-	-	-	AAA,AAA_assoc_2,MgsA_C,RuvB_N
HKD2_k127_7681415_2	452652.KSE_20200	6.241e-200	649.0	COG2409@1|root,COG2409@2|Bacteria,2GJ5A@201174|Actinobacteria,2M0UE@2063|Kitasatospora	201174|Actinobacteria	S	MMPL family	-	-	-	ko:K06994	-	-	-	-	ko00000	-	-	-	MMPL
HKD2_k127_7681415_7	390989.JOEG01000002_gene4261	9.645e-84	293.0	COG2843@1|root,COG2843@2|Bacteria,2GK15@201174|Actinobacteria,4DA3D@85008|Micromonosporales	201174|Actinobacteria	M	Bacterial capsule synthesis protein PGA_cap	-	-	-	ko:K07282	-	-	-	-	ko00000	-	-	-	PGA_cap
HKD2_k127_7681415_1	58123.JOFJ01000030_gene1191	4.724e-234	742.0	COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria,4EG41@85012|Streptosporangiales	201174|Actinobacteria	IQ	AMP-binding enzyme	alkK	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
HKD2_k127_7681415_0	1123322.KB904647_gene1639	1.687e-258	816.0	COG0173@1|root,COG0173@2|Bacteria,2GJHU@201174|Actinobacteria	201174|Actinobacteria	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
HKD2_k127_7681415_4	2002.JOEQ01000026_gene400	5.289e-180	576.0	COG0124@1|root,COG0124@2|Bacteria,2GIYJ@201174|Actinobacteria,4EGCH@85012|Streptosporangiales	201174|Actinobacteria	J	Histidyl-tRNA synthetase	hisS	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
HKD2_k127_7681415_6	58123.JOFJ01000017_gene4158	4.133e-94	314.0	COG0491@1|root,COG0491@2|Bacteria,2GJU0@201174|Actinobacteria,4EHV3@85012|Streptosporangiales	201174|Actinobacteria	S	Metallo-beta-lactamase superfamily	-	-	3.1.2.6	ko:K01069	ko00620,map00620	-	R01736	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	Lactamase_B
HKD2_k127_7681415_14	864069.MicloDRAFT_00069770	8.879e-05	48.0	COG3293@1|root,COG3293@2|Bacteria,1PVIT@1224|Proteobacteria,2TURP@28211|Alphaproteobacteria,1JTPR@119045|Methylobacteriaceae	28211|Alphaproteobacteria	L	PFAM transposase IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF4096
HKD2_k127_7681415_11	485913.Krac_1873	7.715e-15	87.0	COG3293@1|root,COG3293@2|Bacteria	2|Bacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_2,DUF4096
HKD2_k127_7681415_5	1206726.BAFV01000119_gene5917	7.405e-159	515.0	COG0675@1|root,COG0675@2|Bacteria,2GM6K@201174|Actinobacteria,4FZVG@85025|Nocardiaceae	201174|Actinobacteria	L	Transposase	-	-	-	ko:K07496	-	-	-	-	ko00000	-	-	-	HTH_OrfB_IS605,OrfB_IS605,OrfB_Zn_ribbon
HKD2_k127_7681415_8	1463936.JOJI01000003_gene849	4.491e-52	203.0	COG0652@1|root,COG0652@2|Bacteria,2GN8G@201174|Actinobacteria	201174|Actinobacteria	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	ppiB	-	5.2.1.8	ko:K03768	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Pro_isomerase
HKD2_k127_7684029_0	656024.FsymDg_1002	4.086e-157	505.0	COG0213@1|root,COG0213@2|Bacteria,2GJH5@201174|Actinobacteria,4ERU2@85013|Frankiales	201174|Actinobacteria	F	TIGRFAM Pyrimidine-nucleoside phosphorylase	deoA	GO:0003674,GO:0003824,GO:0004645,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0009032,GO:0016740,GO:0016757,GO:0016758,GO:0016763,GO:0044424,GO:0044444,GO:0044464	2.4.2.2,2.4.2.4	ko:K00756,ko:K00758	ko00240,ko00983,ko01100,ko05219,map00240,map00983,map01100,map05219	-	R01570,R01876,R02296,R02484,R08222,R08230	RC00063	ko00000,ko00001,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3,PYNP_C
HKD2_k127_7684029_1	1236902.ANAS01000012_gene855	1.022e-47	183.0	COG0295@1|root,COG0295@2|Bacteria,2IHP7@201174|Actinobacteria,4EJGV@85012|Streptosporangiales	201174|Actinobacteria	F	Cytidine and deoxycytidylate deaminase zinc-binding region	cdd	-	3.5.4.5	ko:K01489	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01878,R02485,R08221	RC00074,RC00514	ko00000,ko00001,ko01000	-	-	-	dCMP_cyt_deam_1,dCMP_cyt_deam_2
HKD2_k127_7684029_2	656024.FsymDg_0998	4.335e-28	127.0	COG0515@1|root,COG0515@2|Bacteria,2GIV0@201174|Actinobacteria	201174|Actinobacteria	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HKD2_k127_7691926_9	44060.JODL01000009_gene1918	0.0001075	47.0	2EUHF@1|root,33MZK@2|Bacteria,2ISV6@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7691926_8	656024.FsymDg_3647	2.064e-24	111.0	2DSVA@1|root,33HJF@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF4439)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4439
HKD2_k127_7691926_7	365528.KB891241_gene6175	2.217e-68	249.0	COG1011@1|root,COG1011@2|Bacteria	2|Bacteria	S	phosphatase activity	-	-	3.1.3.10	ko:K07025,ko:K20866	ko00010,ko01120,map00010,map01120	-	R00947	RC00078	ko00000,ko00001,ko01000	-	-	-	HAD_2,Hydrolase,Hydrolase_like
HKD2_k127_7691926_0	58344.JOEL01000065_gene5494	3.5e-222	702.0	COG0442@1|root,COG0442@2|Bacteria,2GJ9G@201174|Actinobacteria	201174|Actinobacteria	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS	proS	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA_edit
HKD2_k127_7691926_4	656024.FsymDg_3652	2.74e-139	447.0	COG3393@1|root,COG3393@2|Bacteria,2GMD2@201174|Actinobacteria,4ERYU@85013|Frankiales	201174|Actinobacteria	S	PFAM GCN5-related N-acetyltransferase	-	-	-	ko:K06976	-	-	-	-	ko00000	-	-	-	Acetyltransf_1,DUF4081,FR47
HKD2_k127_7691926_1	298653.Franean1_1170	1.971e-205	643.0	COG0821@1|root,COG0821@2|Bacteria,2GK2S@201174|Actinobacteria,4ERRE@85013|Frankiales	201174|Actinobacteria	I	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate	ispG	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016020,GO:0016491,GO:0016725,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030312,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044464,GO:0046429,GO:0046490,GO:0052592,GO:0055114,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901576	1.17.7.1,1.17.7.3	ko:K03526	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R08689,R10859	RC01486	ko00000,ko00001,ko00002,ko01000	-	-	-	GcpE
HKD2_k127_7691926_2	326424.FRAAL5773	7.297e-146	493.0	COG0750@1|root,COG0750@2|Bacteria,2GJJT@201174|Actinobacteria,4ESD0@85013|Frankiales	201174|Actinobacteria	M	PFAM peptidase M50	rip1	GO:0008150,GO:0040007	-	ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_M50
HKD2_k127_7691926_3	67373.JOBF01000019_gene5843	8.339e-140	473.0	COG0743@1|root,COG0743@2|Bacteria,2GIRV@201174|Actinobacteria	201174|Actinobacteria	I	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)	dxr	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016114,GO:0016491,GO:0016614,GO:0016616,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030145,GO:0030604,GO:0032787,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046490,GO:0046872,GO:0046914,GO:0048037,GO:0050661,GO:0050662,GO:0051483,GO:0051484,GO:0055114,GO:0070402,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901265,GO:1901363,GO:1901576	1.1.1.267	ko:K00099	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05688	RC01452	ko00000,ko00001,ko00002,ko01000	-	-	-	DXPR_C,DXP_redisom_C,DXP_reductoisom
HKD2_k127_7691926_6	656024.FsymDg_3656	4.919e-78	284.0	COG3509@1|root,COG3509@2|Bacteria,2GNV6@201174|Actinobacteria	201174|Actinobacteria	Q	Poly(3-hydroxybutyrate) depolymerase	-	-	-	ko:K03932	-	-	-	-	ko00000	-	CE1	-	Esterase_phd
HKD2_k127_7691926_5	222534.KB893794_gene2542	7.269e-132	424.0	COG0820@1|root,COG0820@2|Bacteria,2GJ48@201174|Actinobacteria,4ERPT@85013|Frankiales	201174|Actinobacteria	J	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs	rlmN	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0030312,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:0140102,GO:1901360	2.1.1.192	ko:K06941	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Radical_SAM
HKD2_k127_7692453_3	298653.Franean1_1255	1.24e-15	88.0	COG0746@1|root,COG0746@2|Bacteria,2HTMU@201174|Actinobacteria,4ETKE@85013|Frankiales	201174|Actinobacteria	H	molybdenum cofactor guanylyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7692453_2	656024.FsymDg_3582	1.737e-45	188.0	COG0746@1|root,COG0746@2|Bacteria,2GJVE@201174|Actinobacteria,4ETB3@85013|Frankiales	201174|Actinobacteria	H	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor	mobA	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_3
HKD2_k127_7692453_0	710111.FraQA3DRAFT_5905	4.283e-160	509.0	COG2896@1|root,COG2896@2|Bacteria,2GN0V@201174|Actinobacteria,4ESA6@85013|Frankiales	201174|Actinobacteria	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Fer4_14,Mob_synth_C,Radical_SAM
HKD2_k127_7692453_1	1123023.JIAI01000005_gene822	1.067e-92	318.0	COG1940@1|root,COG1940@2|Bacteria,2GJA0@201174|Actinobacteria,4E0WG@85010|Pseudonocardiales	201174|Actinobacteria	GK	Transcriptional regulator sugar kinase	ppgK	-	2.7.1.2,2.7.1.63	ko:K00845,ko:K00886	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786,R02187,R02189	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
HKD2_k127_7692453_4	1146883.BLASA_3298	2.439e-13	77.0	COG1316@1|root,COG1316@2|Bacteria	2|Bacteria	K	TRANSCRIPTIONal	-	-	-	-	-	-	-	-	-	-	-	-	LytR_C
HKD2_k127_7700783_2	211114.JOEF01000037_gene6876	3.218e-18	87.0	COG0715@1|root,COG0715@2|Bacteria,2I95I@201174|Actinobacteria,4E1JF@85010|Pseudonocardiales	201174|Actinobacteria	P	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7700783_3	446462.Amir_2815	1.35e-12	75.0	COG0500@1|root,COG2226@2|Bacteria,2II6W@201174|Actinobacteria	201174|Actinobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
HKD2_k127_7700783_1	1123320.KB889684_gene2301	1.179e-19	94.0	COG0500@1|root,COG2226@2|Bacteria,2II6W@201174|Actinobacteria	201174|Actinobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
HKD2_k127_7700783_4	1155714.KB891988_gene2024	4.477e-08	57.0	COG2050@1|root,COG2050@2|Bacteria,2IKTU@201174|Actinobacteria	201174|Actinobacteria	Q	PFAM thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
HKD2_k127_7700783_5	83332.Rv0229c	1.934e-05	48.0	COG1487@1|root,COG1487@2|Bacteria,2IRPF@201174|Actinobacteria,23F4G@1762|Mycobacteriaceae	201174|Actinobacteria	S	toxic component of a	-	-	-	-	-	-	-	-	-	-	-	-	PIN
HKD2_k127_7700783_0	1380390.JIAT01000009_gene614	9.566e-70	238.0	COG1028@1|root,COG1028@2|Bacteria,2GKVM@201174|Actinobacteria,4CQ62@84995|Rubrobacteria	84995|Rubrobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HKD2_k127_7722226_1	106370.Francci3_4370	3.81e-70	241.0	COG0151@1|root,COG0151@2|Bacteria,2I2F5@201174|Actinobacteria,4ERHW@85013|Frankiales	201174|Actinobacteria	F	Belongs to the GARS family	purD	GO:0008150,GO:0040007	6.3.3.1,6.3.4.13	ko:K01945,ko:K11788	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144,R04208	RC00090,RC00166,RC01100	ko00000,ko00001,ko00002,ko01000	-	-	-	GARS_A,GARS_C,GARS_N
HKD2_k127_7722226_2	298654.FraEuI1c_0197	8.805e-59	210.0	COG0041@1|root,COG0041@2|Bacteria,2IFFD@201174|Actinobacteria,4ESMK@85013|Frankiales	201174|Actinobacteria	F	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)	purE	-	5.4.99.18	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07405	RC01947	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRC
HKD2_k127_7722226_0	298655.KI912266_gene1392	5.788e-233	731.0	COG0015@1|root,COG0015@2|Bacteria,2GKBR@201174|Actinobacteria,4ESA7@85013|Frankiales	201174|Actinobacteria	F	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily	purB	-	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	-	ADSL_C,Lyase_1
HKD2_k127_7722226_3	298653.Franean1_0202	9.229e-06	49.0	COG0152@1|root,COG0152@2|Bacteria,2GK3H@201174|Actinobacteria,4ERID@85013|Frankiales	201174|Actinobacteria	F	SAICAR synthetase	purC	GO:0003674,GO:0003824,GO:0004639,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.2.6,6.3.4.13	ko:K01923,ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144,R04591	RC00064,RC00090,RC00162,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	SAICAR_synt
HKD2_k127_7729302_0	365528.KB891208_gene3149	1.206e-210	661.0	COG1250@1|root,COG1250@2|Bacteria,2GJBM@201174|Actinobacteria,4ERI1@85013|Frankiales	201174|Actinobacteria	I	3-hydroxyacyl-CoA dehydrogenase	-	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
HKD2_k127_7729302_1	298653.Franean1_1038	8.39e-52	189.0	COG3339@1|root,COG3339@2|Bacteria,2IMW8@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF1232)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1232
HKD2_k127_7729302_2	298655.KI912266_gene2146	3.745e-20	98.0	2E3EP@1|root,32YDP@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7729302_3	479432.Sros_1691	1.24e-07	59.0	COG2945@1|root,COG2945@2|Bacteria,2GP8G@201174|Actinobacteria,4EHK6@85012|Streptosporangiales	201174|Actinobacteria	S	hydrolase of the alpha beta	-	-	-	ko:K07018	-	-	-	-	ko00000	-	-	-	Abhydrolase_6
HKD2_k127_7742354_9	1968.JOEV01000007_gene4010	1.493e-59	214.0	2C28Q@1|root,33N7K@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K14627	ko01057,ko01130,map01057,map01130	M00779	R09308	RC02485	ko00000,ko00001,ko00002,ko01000,ko01008	-	-	-	-
HKD2_k127_7742354_3	100226.SCO5073	4.462e-139	448.0	COG0604@1|root,COG0604@2|Bacteria,2GKHW@201174|Actinobacteria	201174|Actinobacteria	C	NADPH quinone reductase	-	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N,ADH_zinc_N_2
HKD2_k127_7742354_5	100226.SCO5072	6.178e-119	398.0	COG1250@1|root,COG1250@2|Bacteria,2GNXI@201174|Actinobacteria	201174|Actinobacteria	I	3-hydroxyacyl-CoA dehydrogenase	-	-	1.1.1.108	ko:K05556,ko:K17735	ko01057,ko01130,map01057,map01130	M00779	R09306,R09307,R09308	RC02484,RC02485	ko00000,ko00001,ko00002,ko01000,ko01008	-	-	-	3HCDH,3HCDH_N
HKD2_k127_7742354_11	106370.Francci3_4104	1.323e-50	192.0	COG5517@1|root,COG5517@2|Bacteria,2INCM@201174|Actinobacteria	201174|Actinobacteria	Q	SnoaL-like domain	-	-	-	ko:K14626	ko01057,ko01130,map01057,map01130	M00779	R09308	RC02485	ko00000,ko00001,ko00002	-	-	-	SnoaL_4
HKD2_k127_7742354_13	103733.JNYO01000091_gene6477	1.709e-31	140.0	COG0511@1|root,COG0511@2|Bacteria,2IR3V@201174|Actinobacteria,4E76F@85010|Pseudonocardiales	201174|Actinobacteria	I	Biotin-requiring enzyme	-	-	-	ko:K02160	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742	RC00040,RC00367	ko00000,ko00001,ko00002	-	-	-	Biotin_lipoyl
HKD2_k127_7742354_4	512565.AMIS_50680	8.56e-126	409.0	COG1028@1|root,COG1028@2|Bacteria,2H0SM@201174|Actinobacteria,4DBQQ@85008|Micromonosporales	201174|Actinobacteria	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	ko:K12420	ko00253,ko01056,ko01130,map00253,map01056,map01130	M00778	R06642,R09262,R09263,R09264	RC00029,RC00144	ko00000,ko00001,ko00002,ko01000,ko01004,ko01008	-	-	-	adh_short
HKD2_k127_7742354_2	1206737.BAGF01000059_gene3913	6.465e-203	661.0	COG0439@1|root,COG0439@2|Bacteria,2I2S0@201174|Actinobacteria,4FWRD@85025|Nocardiaceae	201174|Actinobacteria	I	Biotin carboxylase C-terminal domain	accC	-	6.3.4.14,6.4.1.2	ko:K01961	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04385	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2,PP-binding
HKD2_k127_7742354_0	103733.JNYO01000015_gene3551	6.936e-248	780.0	COG0777@1|root,COG0825@1|root,COG0777@2|Bacteria,COG0825@2|Bacteria,2GNP7@201174|Actinobacteria,4E0S8@85010|Pseudonocardiales	201174|Actinobacteria	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA	accA	-	2.1.3.15,6.4.1.2	ko:K01962,ko:K01963	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	ACCA,Biotin_carb_N,Carboxyl_trans
HKD2_k127_7742354_12	1463861.JNXE01000026_gene3207	2.284e-48	182.0	COG1853@1|root,COG1853@2|Bacteria,2IJ0Q@201174|Actinobacteria	201174|Actinobacteria	S	flavin reductase	actVB	GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0016645,GO:0016646,GO:0042602,GO:0055114	-	ko:K14631	ko01057,ko01130,map01057,map01130	M00779	R05705	RC00126	ko00000,ko00001,ko00002,ko01000	-	-	-	Flavin_Reduct
HKD2_k127_7742354_7	749927.AMED_5421	6.909e-70	245.0	COG3629@1|root,COG3903@1|root,COG3629@2|Bacteria,COG3903@2|Bacteria	2|Bacteria	K	ADP binding	-	-	-	-	-	-	-	-	-	-	-	-	BTAD,NB-ARC,TPR_12,Trans_reg_C
HKD2_k127_7742354_8	477641.MODMU_2504	6.524e-65	241.0	COG1404@1|root,COG1404@2|Bacteria,2GNIX@201174|Actinobacteria,4ET9T@85013|Frankiales	201174|Actinobacteria	O	Peptidase S8 and S53 subtilisin kexin sedolisin	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
HKD2_k127_7742354_1	134676.ACPL_4895	1.894e-230	756.0	COG4995@1|root,COG4995@2|Bacteria,2GKCX@201174|Actinobacteria,4DBR2@85008|Micromonosporales	201174|Actinobacteria	S	CHAT domain	-	-	-	-	-	-	-	-	-	-	-	-	CHAT
HKD2_k127_7742354_16	345341.KUTG_04400	1.224e-22	114.0	2E61P@1|root,330QX@2|Bacteria,2II66@201174|Actinobacteria,4E5U0@85010|Pseudonocardiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7742354_10	134676.ACPL_4897	8.773e-56	204.0	COG1595@1|root,COG1595@2|Bacteria,2GJUI@201174|Actinobacteria,4DEDK@85008|Micromonosporales	201174|Actinobacteria	K	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
HKD2_k127_7742354_6	1150864.MILUP08_42737	1.694e-88	309.0	COG0286@1|root,COG0732@1|root,COG0286@2|Bacteria,COG0732@2|Bacteria,2GKAQ@201174|Actinobacteria	201174|Actinobacteria	V	Type I restriction-modification system methyltransferase subunit	-	-	-	-	-	-	-	-	-	-	-	-	N6_Mtase
HKD2_k127_7742354_17	1869.MB27_27970	3.461e-14	81.0	COG0286@1|root,COG0732@1|root,COG0286@2|Bacteria,COG0732@2|Bacteria,2GKAQ@201174|Actinobacteria,4DIA7@85008|Micromonosporales	201174|Actinobacteria	V	DNA methylase	-	-	-	-	-	-	-	-	-	-	-	-	N6_Mtase
HKD2_k127_7742354_14	105425.BBPL01000018_gene2	1.641e-28	119.0	COG4637@1|root,COG4637@2|Bacteria,2HQUP@201174|Actinobacteria,2NMMK@228398|Streptacidiphilus	201174|Actinobacteria	S	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	-	-	-	-	-	-	-	-	-	AAA_21
HKD2_k127_7742354_15	749414.SBI_03806	1.467e-23	111.0	2CAZG@1|root,2ZBT6@2|Bacteria,2GW3H@201174|Actinobacteria	201174|Actinobacteria	S	Domain of unknown function (DUF4276)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4276
HKD2_k127_7743490_4	106370.Francci3_0869	8.148e-73	262.0	COG0127@1|root,COG0127@2|Bacteria,2GM2B@201174|Actinobacteria,4ESQ0@85013|Frankiales	201174|Actinobacteria	F	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions	rdgB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576	3.6.1.66	ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000	-	-	-	Ham1p_like
HKD2_k127_7743490_3	656024.FsymDg_1246	1.737e-115	376.0	COG0689@1|root,COG0689@2|Bacteria,2GJFI@201174|Actinobacteria,4ERUJ@85013|Frankiales	201174|Actinobacteria	J	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates	rph	GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0019439,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:1901360,GO:1901361,GO:1901575	2.7.7.56	ko:K00989	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RNase_PH,RNase_PH_C
HKD2_k127_7743490_2	365528.KB891233_gene1740	1.268e-115	377.0	COG1234@1|root,COG1234@2|Bacteria,2GMEX@201174|Actinobacteria,4ESWI@85013|Frankiales	201174|Actinobacteria	S	Beta-lactamase superfamily domain	yhfI	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0031123,GO:0034414,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0042779,GO:0042780,GO:0042781,GO:0043170,GO:0043628,GO:0044237,GO:0044238,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1905267	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
HKD2_k127_7743490_1	477641.MODMU_1394	3.083e-131	423.0	COG0796@1|root,COG0796@2|Bacteria,2GN4I@201174|Actinobacteria,4ERE1@85013|Frankiales	201174|Actinobacteria	M	Provides the (R)-glutamate required for cell wall biosynthesis	murI	GO:0000270,GO:0003674,GO:0003824,GO:0004857,GO:0005575,GO:0005623,GO:0005886,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008657,GO:0008881,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0010911,GO:0016020,GO:0016853,GO:0016854,GO:0016855,GO:0030203,GO:0030234,GO:0032780,GO:0034645,GO:0036361,GO:0042030,GO:0042546,GO:0043086,GO:0043170,GO:0043462,GO:0044036,GO:0044038,GO:0044085,GO:0044092,GO:0044237,GO:0044249,GO:0044260,GO:0044464,GO:0047661,GO:0050790,GO:0051336,GO:0051346,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0072586,GO:0098772,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576,GO:2000371,GO:2000372	5.1.1.3	ko:K01776	ko00471,ko01100,map00471,map01100	-	R00260	RC00302	ko00000,ko00001,ko01000,ko01011	-	-	-	Asp_Glu_race
HKD2_k127_7743490_0	446462.Amir_0917	1.008e-132	427.0	COG2188@1|root,COG2188@2|Bacteria,2GUDN@201174|Actinobacteria,4DXAJ@85010|Pseudonocardiales	201174|Actinobacteria	K	helix_turn_helix gluconate operon transcriptional repressor	-	-	-	-	-	-	-	-	-	-	-	-	GntR
HKD2_k127_7743490_5	479435.Kfla_0383	1.608e-47	180.0	COG0546@1|root,COG0546@2|Bacteria,2GMCV@201174|Actinobacteria,4DV10@85009|Propionibacteriales	201174|Actinobacteria	S	Haloacid dehalogenase-like hydrolase	-	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
HKD2_k127_7830395_0	1184609.KILIM_108_00060	3.941e-69	243.0	COG0610@1|root,COG0610@2|Bacteria,2HI69@201174|Actinobacteria,4F84F@85018|Dermatophilaceae	201174|Actinobacteria	V	Type I restriction enzyme R protein N terminus (HSDR_N)	hsdR	-	3.1.21.3	ko:K01153	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	DUF3387,HSDR_N,ResIII
HKD2_k127_7830395_2	419947.MRA_0756	2.443e-18	87.0	2DDJC@1|root,2ZIAU@2|Bacteria,2HABV@201174|Actinobacteria	201174|Actinobacteria	-	-	-	GO:0008150,GO:0040008,GO:0045927,GO:0048518,GO:0050789,GO:0065007	-	-	-	-	-	-	-	-	-	-	RHH_1
HKD2_k127_7830395_1	419947.MRA_0285	6.368e-42	162.0	COG1848@1|root,COG1848@2|Bacteria,2ITEJ@201174|Actinobacteria	201174|Actinobacteria	S	Toxic component of a type II toxin-antitoxin (TA) system. An RNase (By similarity). Upon expression in M.smegmatis inhibits colony formation. Its toxic effect is neutralized by coexpression with cognate antitoxin	-	GO:0008150,GO:0040008,GO:0045926,GO:0048519,GO:0050789,GO:0065007	-	ko:K07064	-	-	-	-	ko00000	-	-	-	PIN
HKD2_k127_7854769_4	1121272.KB903250_gene2835	1.016e-11	66.0	COG0412@1|root,COG0412@2|Bacteria,2GJMH@201174|Actinobacteria,4D93K@85008|Micromonosporales	201174|Actinobacteria	Q	Dienelactone hydrolase family	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
HKD2_k127_7854769_1	106370.Francci3_3920	2.31e-122	400.0	COG0248@1|root,COG0248@2|Bacteria,2GJBN@201174|Actinobacteria,4ERG4@85013|Frankiales	201174|Actinobacteria	FP	Ppx GppA phosphatase	ppx	-	3.6.1.11,3.6.1.40	ko:K01524	ko00230,map00230	-	R03409	RC00002	ko00000,ko00001,ko01000	-	-	-	Ppx-GppA
HKD2_k127_7854769_2	656024.FsymDg_0757	2.387e-67	248.0	COG1507@1|root,COG1507@2|Bacteria,2I8CS@201174|Actinobacteria,4ESU2@85013|Frankiales	201174|Actinobacteria	S	Protein of unknown function (DUF501)	-	-	-	ko:K09009	-	-	-	-	ko00000	-	-	-	DUF501
HKD2_k127_7854769_3	298655.KI912266_gene1869	2.786e-25	119.0	COG2919@1|root,COG2919@2|Bacteria,2GQH7@201174|Actinobacteria,4ETKM@85013|Frankiales	201174|Actinobacteria	D	Septum formation initiator	divIC	-	-	ko:K13052	-	-	-	-	ko00000,ko03036	-	-	-	DivIC
HKD2_k127_7854769_0	298655.KI912266_gene1868	4.681e-160	509.0	COG0148@1|root,COG0148@2|Bacteria,2GJAY@201174|Actinobacteria,4ERMF@85013|Frankiales	201174|Actinobacteria	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
HKD2_k127_7855934_6	1449976.KALB_7721	8.583e-13	78.0	COG3324@1|root,COG3324@2|Bacteria,2GJFC@201174|Actinobacteria,4E3XB@85010|Pseudonocardiales	201174|Actinobacteria	S	Glyoxalase bleomycin resistance protein dioxygenase	-	-	-	ko:K06996	-	-	-	-	ko00000	-	-	-	Glyoxalase
HKD2_k127_7855934_2	1206744.BAGL01000050_gene920	4.379e-62	225.0	COG3246@1|root,COG3246@2|Bacteria,2GMMZ@201174|Actinobacteria,4G77K@85025|Nocardiaceae	201174|Actinobacteria	S	beta-keto acid cleavage enzyme	-	-	-	-	-	-	-	-	-	-	-	-	BKACE
HKD2_k127_7855934_5	68570.DC74_5381	1.078e-22	102.0	2EGF3@1|root,33A73@2|Bacteria,2IQGU@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF3311)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3311
HKD2_k127_7855934_1	1003195.SCAT_4088	3.06e-105	348.0	COG0591@1|root,COG0591@2|Bacteria,2GJ5E@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	-	-	-	ko:K03307	-	-	-	-	ko00000	2.A.21	-	-	SSF
HKD2_k127_7855934_8	365528.KB891178_gene4767	0.0007674	51.0	COG5433@1|root,COG5433@2|Bacteria,2HYBN@201174|Actinobacteria,4EWGM@85013|Frankiales	201174|Actinobacteria	L	required for the transposition of insertion element IS2404	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_assoc
HKD2_k127_7855934_4	1146883.BLASA_1512	3.768e-29	124.0	COG1204@1|root,COG1204@2|Bacteria,2GM8Y@201174|Actinobacteria	201174|Actinobacteria	L	helicase	-	-	-	-	-	-	-	-	-	-	-	-	DEAD,HIRAN,Helicase_C
HKD2_k127_7856095_7	656024.FsymDg_3337	6.558e-18	88.0	2DRKZ@1|root,33C8D@2|Bacteria,2I1C7@201174|Actinobacteria,4ETMF@85013|Frankiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7856095_6	1120948.KB903221_gene498	1.362e-49	183.0	COG5637@1|root,COG5637@2|Bacteria,2GP5P@201174|Actinobacteria,4E5SQ@85010|Pseudonocardiales	201174|Actinobacteria	S	Polyketide cyclase / dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc
HKD2_k127_7856095_8	1122611.KB903950_gene6363	3.565e-17	90.0	2ERVT@1|root,33JEZ@2|Bacteria,2I15W@201174|Actinobacteria,4EM17@85012|Streptosporangiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7856095_3	326424.FRAAL3903	8.628e-114	381.0	COG3569@1|root,COG3569@2|Bacteria,2GJTH@201174|Actinobacteria,4ESDY@85013|Frankiales	201174|Actinobacteria	L	Eukaryotic DNA topoisomerase I, catalytic core	-	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_I
HKD2_k127_7856095_5	710111.FraQA3DRAFT_0961	1.139e-62	222.0	COG0241@1|root,COG0241@2|Bacteria,2GK77@201174|Actinobacteria,4EVNN@85013|Frankiales	201174|Actinobacteria	E	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	gmhB	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2,Hydrolase_like
HKD2_k127_7856095_2	222534.KB893769_gene4716	1.472e-144	474.0	COG0859@1|root,COG0859@2|Bacteria,2GSTW@201174|Actinobacteria,4EUEG@85013|Frankiales	201174|Actinobacteria	M	Glycosyltransferase family 9 (heptosyltransferase)	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_9,Hydrolase_like
HKD2_k127_7856095_1	710111.FraQA3DRAFT_0959	4.635e-162	539.0	COG0297@1|root,COG0297@2|Bacteria,2I2EE@201174|Actinobacteria,4EUJN@85013|Frankiales	201174|Actinobacteria	G	Glycosyl transferase 4-like	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
HKD2_k127_7856095_0	710111.FraQA3DRAFT_0958	2.095e-244	796.0	COG0279@1|root,COG0615@1|root,COG2870@1|root,COG0279@2|Bacteria,COG0615@2|Bacteria,COG2870@2|Bacteria,2GKU1@201174|Actinobacteria,4ETXU@85013|Frankiales	201174|Actinobacteria	H	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose	hldE	-	2.7.1.167,2.7.7.70	ko:K03272	ko00540,ko01100,map00540,map01100	M00064	R05644,R05646	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CTP_transf_like,PfkB,SIS_2
HKD2_k127_7856095_4	326424.FRAAL3936	6.539e-70	240.0	COG4221@1|root,COG4221@2|Bacteria,2HZEI@201174|Actinobacteria	201174|Actinobacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HKD2_k127_7869015_0	266940.Krad_0988	4.856e-77	263.0	COG0572@1|root,COG0572@2|Bacteria,2I9H4@201174|Actinobacteria	201174|Actinobacteria	F	Fructose transport system kinase	frcK	-	-	-	-	-	-	-	-	-	-	-	PRK
HKD2_k127_7869015_1	298655.KI912266_gene5486	2.721e-38	143.0	COG0014@1|root,COG0014@2|Bacteria,2GISA@201174|Actinobacteria,4ERK4@85013|Frankiales	201174|Actinobacteria	E	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate	proA	GO:0003674,GO:0003824,GO:0004350,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016620,GO:0016903,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0071944	1.2.1.41	ko:K00147	ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230	M00015	R03313	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv2427c	Aldedh
HKD2_k127_7913773_4	1463858.JOHR01000005_gene1155	1.089e-10	66.0	COG1040@1|root,COG1040@2|Bacteria,2IFV8@201174|Actinobacteria	201174|Actinobacteria	S	competence protein	-	-	-	-	-	-	-	-	-	-	-	-	Pribosyltran
HKD2_k127_7913773_3	68219.JNXI01000014_gene999	5.688e-50	183.0	COG0758@1|root,COG0758@2|Bacteria,2IFTH@201174|Actinobacteria	201174|Actinobacteria	LU	DNA recombination-mediator protein A	-	-	-	ko:K04096	-	-	-	-	ko00000	-	-	-	DNA_processg_A
HKD2_k127_7913773_2	656024.FsymDg_3702	1.849e-51	190.0	COG1920@1|root,COG1920@2|Bacteria,2HJNU@201174|Actinobacteria,4ETD4@85013|Frankiales	201174|Actinobacteria	S	Guanylyltransferase that catalyzes the activation of 2- phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor	cofC	GO:0003674,GO:0003824,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0043814,GO:0044237,GO:0044249,GO:0051186,GO:0051188,GO:0070568	2.7.7.68	ko:K14941	ko00680,ko01120,map00680,map01120	M00378	R09397	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CofC,NTP_transf_3
HKD2_k127_7913773_1	222534.KB893694_gene114	1.697e-55	212.0	COG4188@1|root,COG4188@2|Bacteria,2GZAJ@201174|Actinobacteria	201174|Actinobacteria	S	Platelet-activating factor acetylhydrolase, isoform II	-	-	-	-	-	-	-	-	-	-	-	-	PAF-AH_p_II
HKD2_k127_7913773_0	1123320.KB889676_gene2895	1.68e-72	256.0	COG0204@1|root,COG0204@2|Bacteria,2GKVA@201174|Actinobacteria	201174|Actinobacteria	I	Acyltransferase	plsC2	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
HKD2_k127_7946808_1	1150864.MILUP08_43586	4.815e-92	314.0	COG0318@1|root,COG2124@1|root,COG0318@2|Bacteria,COG2124@2|Bacteria,2GJAA@201174|Actinobacteria,4DB0F@85008|Micromonosporales	201174|Actinobacteria	IQ	AMP-binding enzyme C-terminal domain	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
HKD2_k127_7946808_2	67275.JOAP01000068_gene3731	6.389e-63	226.0	COG0726@1|root,COG0726@2|Bacteria,2GNFA@201174|Actinobacteria	201174|Actinobacteria	G	polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
HKD2_k127_7946808_0	656024.FsymDg_0960	8.346e-106	353.0	COG0483@1|root,COG0483@2|Bacteria,2GKZZ@201174|Actinobacteria,4ERCV@85013|Frankiales	201174|Actinobacteria	G	PFAM Inositol monophosphatase	hisN	-	3.1.3.15,3.1.3.25	ko:K01092,ko:K05602	ko00340,ko00521,ko00562,ko01100,ko01110,ko01230,ko04070,map00340,map00521,map00562,map01100,map01110,map01230,map04070	M00026,M00131	R01185,R01186,R01187,R03013	RC00017,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
HKD2_k127_7946808_3	656024.FsymDg_0959	0.000212	51.0	COG0584@1|root,COG0584@2|Bacteria	2|Bacteria	C	glycerophosphodiester phosphodiesterase activity	-	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD
HKD2_k127_7949776_3	222534.KB893671_gene3182	1.774e-52	197.0	28J4D@1|root,2Z90C@2|Bacteria,2GJYC@201174|Actinobacteria,4ET3P@85013|Frankiales	201174|Actinobacteria	S	Protein of unknown function (DUF3710)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3710
HKD2_k127_7949776_1	656024.FsymDg_1808	8.598e-71	244.0	COG0756@1|root,COG0756@2|Bacteria,2IHYY@201174|Actinobacteria,4ESXH@85013|Frankiales	201174|Actinobacteria	F	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA	dut	GO:0000287,GO:0003674,GO:0003824,GO:0004170,GO:0005488,GO:0006139,GO:0006220,GO:0006221,GO:0006226,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009141,GO:0009143,GO:0009147,GO:0009149,GO:0009157,GO:0009162,GO:0009165,GO:0009166,GO:0009176,GO:0009177,GO:0009200,GO:0009204,GO:0009211,GO:0009213,GO:0009219,GO:0009221,GO:0009223,GO:0009262,GO:0009263,GO:0009264,GO:0009265,GO:0009394,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046078,GO:0046080,GO:0046081,GO:0046385,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0047429,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0072529,GO:0090407,GO:1901135,GO:1901136,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576	3.6.1.23	ko:K01520	ko00240,ko00983,ko01100,map00240,map00983,map01100	M00053	R02100,R11896	RC00002	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	dUTPase
HKD2_k127_7949776_2	1120936.KB907211_gene246	6.069e-57	206.0	COG2050@1|root,COG2050@2|Bacteria,2GKY1@201174|Actinobacteria,4EISK@85012|Streptosporangiales	201174|Actinobacteria	Q	Thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
HKD2_k127_7949776_0	1157637.KB892117_gene8	4.208e-95	319.0	COG1028@1|root,COG1028@2|Bacteria,2I32I@201174|Actinobacteria	201174|Actinobacteria	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HKD2_k127_7949776_6	258052.JNYV01000001_gene449	2.629e-11	70.0	2E4C2@1|root,32Z7M@2|Bacteria,2IFS5@201174|Actinobacteria,2M2X2@2063|Kitasatospora	201174|Actinobacteria	S	Protein of unknown function (DUF3093)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3093
HKD2_k127_7949776_4	298653.Franean1_5197	2.36e-29	120.0	2DR0Y@1|root,339QH@2|Bacteria,2GWIF@201174|Actinobacteria,4ETJG@85013|Frankiales	201174|Actinobacteria	S	Protein of unknown function (DUF4235)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4235
HKD2_k127_7949776_5	756067.MicvaDRAFT_0994	1.989e-12	80.0	COG0596@1|root,COG0596@2|Bacteria	2|Bacteria	S	hydrolase activity, acting on ester bonds	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
HKD2_k127_7955120_5	656024.FsymDg_3631	8.25e-52	194.0	COG0289@1|root,COG0289@2|Bacteria,2GM2T@201174|Actinobacteria,4ERHD@85013|Frankiales	201174|Actinobacteria	E	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate	dapB	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008839,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019752,GO:0019877,GO:0030312,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0048037,GO:0050661,GO:0050662,GO:0051287,GO:0055114,GO:0070402,GO:0070404,GO:0071704,GO:0071944,GO:0097159,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.17.1.8	ko:K00215	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R04198,R04199	RC00478	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv2773c	DapB_C,DapB_N
HKD2_k127_7955120_1	656024.FsymDg_3632	2.304e-190	606.0	COG0612@1|root,COG0612@2|Bacteria,2GJZ3@201174|Actinobacteria,4ERHK@85013|Frankiales	201174|Actinobacteria	S	Belongs to the peptidase M16 family	pepR	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
HKD2_k127_7955120_0	656024.FsymDg_3633	0.0	1208.0	COG1185@1|root,COG1185@2|Bacteria,2GIT2@201174|Actinobacteria,4ERV5@85013|Frankiales	201174|Actinobacteria	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
HKD2_k127_7955120_6	106370.Francci3_3556	3.141e-47	170.0	COG0184@1|root,COG0184@2|Bacteria,2IQA0@201174|Actinobacteria,4ET5M@85013|Frankiales	201174|Actinobacteria	J	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome	rpsO	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0015935,GO:0016020,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071944,GO:1990904	-	ko:K02956	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S15
HKD2_k127_7955120_2	106370.Francci3_3557	4.272e-128	415.0	COG0196@1|root,COG0196@2|Bacteria,2GKQF@201174|Actinobacteria,4ES77@85013|Frankiales	201174|Actinobacteria	H	Belongs to the ribF family	ribF	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0006139,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006771,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008531,GO:0009058,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009124,GO:0009156,GO:0009161,GO:0009165,GO:0009231,GO:0009259,GO:0009260,GO:0009398,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019866,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0034641,GO:0034654,GO:0042364,GO:0042726,GO:0042727,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046390,GO:0046444,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.1.26,2.7.7.2	ko:K11753	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00161,R00549	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_syn,Flavokinase
HKD2_k127_7955120_3	298653.Franean1_1186	1.601e-115	379.0	COG0130@1|root,COG0130@2|Bacteria,2GJZK@201174|Actinobacteria,4ESDN@85013|Frankiales	201174|Actinobacteria	J	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs	truB	GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016556,GO:0016853,GO:0016866,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1990481	5.4.99.25	ko:K03177	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruB_C,TruB_C_2,TruB_N
HKD2_k127_7955120_4	649831.L083_6804	2.076e-67	239.0	COG0618@1|root,COG0618@2|Bacteria,2GN9Z@201174|Actinobacteria,4D9W4@85008|Micromonosporales	201174|Actinobacteria	S	phosphoesterase RecJ domain protein	nrnA	GO:0008150,GO:0040007	3.1.13.3,3.1.3.7	ko:K06881	ko00920,ko01100,ko01120,map00920,map01100,map01120	-	R00188,R00508	RC00078	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
HKD2_k127_7956761_13	326424.FRAAL6867	9.097e-83	304.0	COG0515@1|root,COG0515@2|Bacteria,2GM4A@201174|Actinobacteria,4ET0S@85013|Frankiales	201174|Actinobacteria	KLT	serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
HKD2_k127_7956761_20	298653.Franean1_6528	9.255e-64	235.0	COG0791@1|root,COG0791@2|Bacteria,2IFNI@201174|Actinobacteria,4EWEY@85013|Frankiales	201174|Actinobacteria	M	pfam nlp p60	-	-	-	-	-	-	-	-	-	-	-	-	NLPC_P60
HKD2_k127_7956761_4	656024.FsymDg_4537	2.783e-202	683.0	COG0728@1|root,COG0728@2|Bacteria,2GKN0@201174|Actinobacteria,4ERF4@85013|Frankiales	201174|Actinobacteria	KLT	Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane	mviN	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
HKD2_k127_7956761_7	656024.FsymDg_4536	4.287e-122	423.0	COG3170@1|root,COG3170@2|Bacteria,2GN00@201174|Actinobacteria,4ESX8@85013|Frankiales	201174|Actinobacteria	NU	Tfp pilus assembly protein FimV	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7956761_17	298655.KI912266_gene1149	2.139e-72	247.0	COG1051@1|root,COG1051@2|Bacteria,2I2DG@201174|Actinobacteria,4ESXD@85013|Frankiales	201174|Actinobacteria	F	Belongs to the Nudix hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
HKD2_k127_7956761_35	1394178.AWOO02000091_gene1046	8.186e-19	102.0	COG2606@1|root,COG2606@2|Bacteria,2IPRX@201174|Actinobacteria,4EKN3@85012|Streptosporangiales	201174|Actinobacteria	S	Aminoacyl-tRNA editing domain	-	-	-	-	-	-	-	-	-	-	-	-	tRNA_edit
HKD2_k127_7956761_0	656024.FsymDg_4534	1.79e-238	745.0	COG0617@1|root,COG0617@2|Bacteria,2GMT1@201174|Actinobacteria,4ERQI@85013|Frankiales	201174|Actinobacteria	J	SMART Metal-dependent phosphohydrolase, HD region	pcnA	-	2.7.7.19,2.7.7.72	ko:K00970,ko:K00974	ko03013,ko03018,map03013,map03018	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	HD,PolyA_pol,PolyA_pol_RNAbd
HKD2_k127_7956761_8	1283283.ATXA01000037_gene2304	1.377e-113	381.0	COG0477@1|root,COG2814@2|Bacteria,2I3P4@201174|Actinobacteria,4EXEB@85013|Frankiales	201174|Actinobacteria	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD2_k127_7956761_3	106370.Francci3_4529	1.179e-202	659.0	COG1260@1|root,COG1260@2|Bacteria,2GKHB@201174|Actinobacteria,4ERYP@85013|Frankiales	201174|Actinobacteria	I	PFAM Myo-inositol-1-phosphate synthase	ino1	GO:0003674,GO:0003824,GO:0004512,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009405,GO:0009987,GO:0010125,GO:0010126,GO:0016137,GO:0016138,GO:0016853,GO:0016872,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044272,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0051704,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1901657,GO:1901659	5.5.1.4	ko:K01858	ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130	-	R07324	RC01804	ko00000,ko00001,ko01000	-	-	-	Inos-1-P_synth
HKD2_k127_7956761_11	656024.FsymDg_4530	1.603e-91	304.0	COG1695@1|root,COG1695@2|Bacteria,2GMJM@201174|Actinobacteria,4ESIA@85013|Frankiales	201174|Actinobacteria	K	transcriptional regulator PadR family	-	-	-	-	-	-	-	-	-	-	-	-	PadR,Vir_act_alpha_C
HKD2_k127_7956761_18	710111.FraQA3DRAFT_4899	2.084e-68	235.0	2CQNK@1|root,32SMG@2|Bacteria,2IIJ7@201174|Actinobacteria,4ET55@85013|Frankiales	201174|Actinobacteria	S	Family of unknown function (DUF5318)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5318
HKD2_k127_7956761_27	656024.FsymDg_4528	2.695e-36	147.0	COG0744@1|root,COG0744@2|Bacteria,2GK21@201174|Actinobacteria,4ERFM@85013|Frankiales	201174|Actinobacteria	M	PFAM glycosyl transferase, family 51	pbp5	-	-	-	-	-	-	-	-	-	-	-	Transgly,Transpeptidase
HKD2_k127_7956761_5	656024.FsymDg_4528	4.131e-134	436.0	COG0744@1|root,COG0744@2|Bacteria,2GK21@201174|Actinobacteria,4ERFM@85013|Frankiales	201174|Actinobacteria	M	PFAM glycosyl transferase, family 51	pbp5	-	-	-	-	-	-	-	-	-	-	-	Transgly,Transpeptidase
HKD2_k127_7956761_31	656024.FsymDg_4528	3.549e-32	147.0	COG0744@1|root,COG0744@2|Bacteria,2GK21@201174|Actinobacteria,4ERFM@85013|Frankiales	201174|Actinobacteria	M	PFAM glycosyl transferase, family 51	pbp5	-	-	-	-	-	-	-	-	-	-	-	Transgly,Transpeptidase
HKD2_k127_7956761_2	656024.FsymDg_4527	9.016e-203	676.0	COG5650@1|root,COG5650@2|Bacteria,2GJYA@201174|Actinobacteria,4ES94@85013|Frankiales	201174|Actinobacteria	S	Glycosyltransferase family 87	-	-	-	-	-	-	-	-	-	-	-	-	GT87
HKD2_k127_7956761_29	656024.FsymDg_4526	4.021e-33	134.0	COG5542@1|root,COG5542@2|Bacteria,2HJW5@201174|Actinobacteria,4ETD2@85013|Frankiales	201174|Actinobacteria	S	integral membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	Mannosyl_trans2
HKD2_k127_7956761_32	365528.KB891230_gene2016	2.775e-29	123.0	COG5542@1|root,COG5542@2|Bacteria,2HTY0@201174|Actinobacteria,4EVF2@85013|Frankiales	201174|Actinobacteria	S	integral membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7956761_10	263358.VAB18032_04320	2.166e-109	366.0	COG0648@1|root,COG0648@2|Bacteria,2GJJQ@201174|Actinobacteria,4DAX4@85008|Micromonosporales	201174|Actinobacteria	L	AP endonuclease family 2	nfo	GO:0003674,GO:0003824,GO:0003906,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008081,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0033554,GO:0034641,GO:0042578,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360	3.1.21.2	ko:K01151	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AP_endonuc_2
HKD2_k127_7956761_24	298654.FraEuI1c_7166	8.037e-44	171.0	COG0360@1|root,COG0360@2|Bacteria,2IQHD@201174|Actinobacteria,4ET1A@85013|Frankiales	201174|Actinobacteria	J	Binds together with S18 to 16S ribosomal RNA	rpsF	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0015935,GO:0016020,GO:0019843,GO:0022626,GO:0022627,GO:0030312,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070181,GO:0071944,GO:0097159,GO:1901363,GO:1990904	-	ko:K02990	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S6
HKD2_k127_7956761_15	222534.KB893717_gene2054	4.531e-77	261.0	COG0629@1|root,COG0629@2|Bacteria,2GMM3@201174|Actinobacteria,4ESDK@85013|Frankiales	201174|Actinobacteria	L	PFAM single-strand binding protein Primosomal replication protein n	ssb	-	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
HKD2_k127_7956761_25	106370.Francci3_4520	1.374e-39	147.0	COG0238@1|root,COG0238@2|Bacteria,2IQ92@201174|Actinobacteria,4ESZ0@85013|Frankiales	201174|Actinobacteria	J	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit	rpsR	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02963	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S18
HKD2_k127_7956761_21	1122611.KB903955_gene5558	4.121e-58	205.0	COG0359@1|root,COG0359@2|Bacteria,2IKX7@201174|Actinobacteria,4EIIV@85012|Streptosporangiales	201174|Actinobacteria	J	binds to the 23S rRNA	rplI	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02939	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L9_C,Ribosomal_L9_N
HKD2_k127_7956761_1	570268.ANBB01000059_gene4202	1.117e-226	721.0	COG0305@1|root,COG1372@1|root,COG0305@2|Bacteria,COG1372@2|Bacteria,2GKXQ@201174|Actinobacteria,4EH2H@85012|Streptosporangiales	201174|Actinobacteria	L	Participates in initiation and elongation during chromosome replication	dnaB	GO:0003674,GO:0003678,GO:0003824,GO:0004386,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0030312,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140097,GO:1901360,GO:1901576	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C,Intein_splicing,LAGLIDADG_3
HKD2_k127_7956761_16	2002.JOEQ01000008_gene1129	1.777e-72	257.0	COG0384@1|root,COG0384@2|Bacteria,2GM1W@201174|Actinobacteria,4EIXN@85012|Streptosporangiales	201174|Actinobacteria	S	Phenazine biosynthesis-like protein	phzF	-	-	-	-	-	-	-	-	-	-	-	PhzC-PhzF
HKD2_k127_7956761_23	2002.JOEQ01000008_gene1129	2.993e-45	169.0	COG0384@1|root,COG0384@2|Bacteria,2GM1W@201174|Actinobacteria,4EIXN@85012|Streptosporangiales	201174|Actinobacteria	S	Phenazine biosynthesis-like protein	phzF	-	-	-	-	-	-	-	-	-	-	-	PhzC-PhzF
HKD2_k127_7956761_33	65497.JODV01000014_gene3351	2.098e-25	114.0	COG1028@1|root,COG1028@2|Bacteria,2GKI2@201174|Actinobacteria,4DZ52@85010|Pseudonocardiales	201174|Actinobacteria	IQ	short-chain alcohol	-	-	-	-	-	-	-	-	-	-	-	-	adh_short,adh_short_C2
HKD2_k127_7956761_14	298655.KI912266_gene3296	5.381e-82	279.0	COG1506@1|root,COG1506@2|Bacteria	2|Bacteria	E	serine-type peptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3,Abhydrolase_6,Peptidase_S9
HKD2_k127_7956761_28	1283283.ATXA01000019_gene2914	1.381e-34	149.0	COG0640@1|root,COG0640@2|Bacteria,2I2TF@201174|Actinobacteria,4EXH1@85013|Frankiales	201174|Actinobacteria	K	Winged helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_34
HKD2_k127_7956761_22	1283283.ATXA01000019_gene2913	1.059e-47	175.0	2F6TA@1|root,33Z9F@2|Bacteria,2IM6V@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7956761_12	365528.KB891210_gene2114	1.407e-86	299.0	COG2197@1|root,COG2197@2|Bacteria,2GJ9U@201174|Actinobacteria,4ESFB@85013|Frankiales	201174|Actinobacteria	T	Two component transcriptional regulator, LuxR family	-	-	-	ko:K07693	ko02020,map02020	M00479	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	GerE,Response_reg
HKD2_k127_7956761_9	298654.FraEuI1c_6874	6.22e-110	370.0	COG4585@1|root,COG4585@2|Bacteria,2GKRM@201174|Actinobacteria,4EUFC@85013|Frankiales	201174|Actinobacteria	T	signal transduction histidine kinase	-	-	2.7.13.3	ko:K07778	ko02020,map02020	M00479	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HisKA_3
HKD2_k127_7956761_19	365528.KB891210_gene2112	1.259e-66	243.0	COG0842@1|root,COG0842@2|Bacteria,2GK5F@201174|Actinobacteria,4ET3E@85013|Frankiales	201174|Actinobacteria	V	PFAM ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane,ABC2_membrane_3
HKD2_k127_7956761_6	365528.KB891210_gene2111	2.996e-122	400.0	COG1131@1|root,COG1131@2|Bacteria,2GJ0Y@201174|Actinobacteria,4ES5Y@85013|Frankiales	201174|Actinobacteria	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD2_k127_7956761_34	2074.JNYD01000032_gene6493	1.302e-24	111.0	2BVHN@1|root,332R2@2|Bacteria,2IPM7@201174|Actinobacteria,4EBR7@85010|Pseudonocardiales	201174|Actinobacteria	S	Pfam:DUF385	-	-	-	-	-	-	-	-	-	-	-	-	F420H2_quin_red
HKD2_k127_7956761_30	710111.FraQA3DRAFT_5116	3.428e-32	130.0	2E65S@1|root,330UF@2|Bacteria,2IMEQ@201174|Actinobacteria,4ETIK@85013|Frankiales	201174|Actinobacteria	S	Domain of unknown function (DUF3817)	-	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DUF3817
HKD2_k127_7956761_26	656024.FsymDg_0660	1.428e-37	145.0	COG1566@1|root,COG1566@2|Bacteria,2ISAW@201174|Actinobacteria,4EWQS@85013|Frankiales	201174|Actinobacteria	V	Glucitol operon activator	lprD	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7956761_36	1449976.KALB_2026	4.853e-12	74.0	COG1011@1|root,COG1011@2|Bacteria	2|Bacteria	S	phosphatase activity	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2,Hydrolase,Hydrolase_like
HKD2_k127_796774_2	298655.KI912266_gene235	1.732e-57	203.0	COG0515@1|root,COG0515@2|Bacteria,2GIV0@201174|Actinobacteria	201174|Actinobacteria	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HKD2_k127_796774_3	1157640.AQWO01000047_gene3138	3.058e-07	61.0	COG0515@1|root,COG0515@2|Bacteria,2GIV0@201174|Actinobacteria	201174|Actinobacteria	KLT	serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
HKD2_k127_796774_0	656024.FsymDg_0995	7.544e-197	632.0	COG1053@1|root,COG1053@2|Bacteria,2GJ45@201174|Actinobacteria	201174|Actinobacteria	C	succinate dehydrogenase	sdhA	GO:0000104,GO:0000166,GO:0001539,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006091,GO:0006113,GO:0006928,GO:0006950,GO:0006974,GO:0006996,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016043,GO:0016491,GO:0016627,GO:0022607,GO:0022900,GO:0030030,GO:0030031,GO:0032991,GO:0033554,GO:0036094,GO:0040011,GO:0043167,GO:0043168,GO:0044085,GO:0044237,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0044780,GO:0044781,GO:0045273,GO:0045274,GO:0045283,GO:0045284,GO:0045333,GO:0048037,GO:0048870,GO:0050660,GO:0050662,GO:0050896,GO:0051179,GO:0051674,GO:0051716,GO:0055114,GO:0070469,GO:0070470,GO:0070925,GO:0071840,GO:0071944,GO:0071949,GO:0071973,GO:0097159,GO:0097588,GO:0098796,GO:0098797,GO:0098803,GO:1901265,GO:1901363	1.3.5.1,1.3.5.4,1.4.3.16	ko:K00239,ko:K00278	ko00020,ko00190,ko00250,ko00650,ko00720,ko00760,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00250,map00650,map00720,map00760,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00115,M00149,M00173,M00374,M00376	R00357,R00481,R02164	RC00006,RC00045,RC02566	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
HKD2_k127_796774_1	479431.Namu_4045	2.866e-70	243.0	COG2890@1|root,COG2890@2|Bacteria,2GITA@201174|Actinobacteria,4EXBG@85013|Frankiales	201174|Actinobacteria	J	S-adenosyl methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_19
HKD2_k127_7972622_5	298654.FraEuI1c_6277	3.308e-81	271.0	COG1060@1|root,COG1060@2|Bacteria,2GK83@201174|Actinobacteria,4EUYV@85013|Frankiales	201174|Actinobacteria	H	Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2)	mqnC	GO:0003674,GO:0003824,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016740,GO:0016765,GO:0044237,GO:0044249,GO:0044689,GO:0051186,GO:0051188	1.21.98.1,2.5.1.77	ko:K11779,ko:K11784	ko00130,ko00680,ko01110,ko01120,map00130,map00680,map01110,map01120	M00378	R08588,R09396	RC01381,RC02329,RC03002,RC03007	ko00000,ko00001,ko00002,ko01000	-	-	-	Radical_SAM
HKD2_k127_7972622_1	656024.FsymDg_4011	1.455e-163	522.0	COG1816@1|root,COG1816@2|Bacteria,2GJ6I@201174|Actinobacteria,4ESZR@85013|Frankiales	201174|Actinobacteria	F	PFAM Adenosine AMP deaminase	-	-	3.5.4.4,3.5.4.40	ko:K01488,ko:K18286	ko00130,ko00230,ko01100,ko01110,ko05340,map00130,map00230,map01100,map01110,map05340	-	R01560,R02556,R10695	RC00477	ko00000,ko00001,ko01000	-	-	-	A_deaminase
HKD2_k127_7972622_4	656024.FsymDg_4010	1.673e-98	345.0	COG0500@1|root,COG2226@2|Bacteria,2GKFZ@201174|Actinobacteria,4ERZ2@85013|Frankiales	201174|Actinobacteria	H	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2)	menG	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Ubie_methyltran
HKD2_k127_7972622_0	106370.Francci3_0537	8.524e-208	657.0	COG0644@1|root,COG0644@2|Bacteria,2GKGH@201174|Actinobacteria,4ERPF@85013|Frankiales	201174|Actinobacteria	C	geranylgeranyl reductase	-	-	1.3.99.38	ko:K21401	-	-	-	-	ko00000,ko01000	-	-	-	DAO,FAD_binding_3,Trp_halogenase
HKD2_k127_7972622_2	656024.FsymDg_4006	1.329e-108	361.0	COG0377@1|root,COG0377@2|Bacteria,2GJXR@201174|Actinobacteria,4ERM4@85013|Frankiales	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoB	-	1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q6
HKD2_k127_7972622_3	106370.Francci3_0540	7.54e-99	338.0	COG0852@1|root,COG0852@2|Bacteria,2GIRH@201174|Actinobacteria,4ESFW@85013|Frankiales	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoC	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006091,GO:0008137,GO:0008150,GO:0008152,GO:0009987,GO:0015980,GO:0016491,GO:0016651,GO:0016655,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0050136,GO:0055114	1.6.5.3	ko:K00332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa
HKD2_k127_7972622_6	710111.FraQA3DRAFT_3920	1.592e-59	211.0	COG0649@1|root,COG0649@2|Bacteria,2GKEZ@201174|Actinobacteria,4ERIR@85013|Frankiales	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoD	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	1.6.5.3	ko:K00333	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa
HKD2_k127_8006222_5	215803.DB30_1485	4.431e-13	70.0	COG2931@1|root,COG2931@2|Bacteria,1QX4P@1224|Proteobacteria,439K8@68525|delta/epsilon subdivisions,2X4WY@28221|Deltaproteobacteria,2YZS2@29|Myxococcales	28221|Deltaproteobacteria	Q	PAP2 superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PAP2
HKD2_k127_8006222_4	1449346.JQMO01000003_gene5992	7.624e-27	118.0	COG0589@1|root,COG0589@2|Bacteria,2IQPQ@201174|Actinobacteria,2M3NK@2063|Kitasatospora	201174|Actinobacteria	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD2_k127_8006222_1	710111.FraQA3DRAFT_2773	1.936e-99	329.0	COG2197@1|root,COG2197@2|Bacteria,2GK4B@201174|Actinobacteria,4ESHE@85013|Frankiales	201174|Actinobacteria	T	Two component transcriptional regulator, LuxR family	-	-	-	ko:K07695	ko02020,map02020	M00482	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	GerE,Response_reg
HKD2_k127_8006222_3	1996.JOFO01000048_gene2722	8.238e-32	128.0	COG1937@1|root,COG1937@2|Bacteria,2IQ7U@201174|Actinobacteria,4EK4P@85012|Streptosporangiales	201174|Actinobacteria	S	Metal-sensitive transcriptional repressor	-	-	-	-	-	-	-	-	-	-	-	-	Trns_repr_metal
HKD2_k127_8006222_0	1150864.MILUP08_41810	6.111e-162	534.0	COG3850@1|root,COG3850@2|Bacteria,2GIWI@201174|Actinobacteria,4D91E@85008|Micromonosporales	201174|Actinobacteria	T	GAF domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HATPase_c_2,HisKA_3
HKD2_k127_8006222_2	1211815.CBYP010000003_gene999	1.838e-71	257.0	COG0778@1|root,COG0778@2|Bacteria,2I8P3@201174|Actinobacteria,4EV9V@85013|Frankiales	201174|Actinobacteria	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
HKD2_k127_8006819_1	485913.Krac_8974	1.405e-110	372.0	COG0547@1|root,COG0547@2|Bacteria	2|Bacteria	E	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)	-	-	-	ko:K21572	-	-	-	-	ko00000,ko02000	8.A.46.1,8.A.46.3	-	-	Glycos_trans_3N,Glycos_transf_3,SusD-like_3,SusD_RagB
HKD2_k127_8006819_3	526225.Gobs_1059	9.96e-80	272.0	29UQ5@1|root,30G1W@2|Bacteria,2II02@201174|Actinobacteria,4EV3Q@85013|Frankiales	201174|Actinobacteria	C	spheroidene monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8006819_2	222534.KB893671_gene3268	1.402e-83	284.0	COG0454@1|root,COG0456@2|Bacteria,2GM3A@201174|Actinobacteria,4ET2U@85013|Frankiales	201174|Actinobacteria	K	PFAM GCN5-related N-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10,Acetyltransf_7
HKD2_k127_8006819_0	1429046.RR21198_3407	8.524e-181	582.0	COG1233@1|root,COG1233@2|Bacteria,2IE6C@201174|Actinobacteria,4FURX@85025|Nocardiaceae	201174|Actinobacteria	Q	Flavin containing amine oxidoreductase	crtO	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase,NAD_binding_8
HKD2_k127_8007207_12	13333.ERN11105	6.155e-14	73.0	COG0076@1|root,KOG1383@2759|Eukaryota,37PA0@33090|Viridiplantae,3GG33@35493|Streptophyta	35493|Streptophyta	E	Belongs to the group II decarboxylase family	-	GO:0005575,GO:0005911,GO:0009506,GO:0030054,GO:0055044	4.1.1.15	ko:K01580	ko00250,ko00410,ko00430,ko00650,ko01100,ko01110,ko01120,ko02024,ko04727,ko04940,map00250,map00410,map00430,map00650,map01100,map01110,map01120,map02024,map04727,map04940	M00027	R00261,R00489,R01682,R02466	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Pyridoxal_deC
HKD2_k127_8007207_0	326424.FRAAL5108	8.042e-234	740.0	COG0322@1|root,COG0847@1|root,COG0322@2|Bacteria,COG0847@2|Bacteria,2GMC0@201174|Actinobacteria,4ES95@85013|Frankiales	201174|Actinobacteria	L	DNA polymerase III, epsilon subunit	dnaQ	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009380,GO:0009987,GO:0016020,GO:0030312,GO:0032991,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0071944,GO:1902494,GO:1905347,GO:1905348,GO:1990391	2.7.7.7	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	GIY-YIG,RNase_T,UVR
HKD2_k127_8007207_11	1146883.BLASA_2114	1.321e-31	133.0	COG1522@1|root,COG1522@2|Bacteria,2IQD4@201174|Actinobacteria,4ETA3@85013|Frankiales	201174|Actinobacteria	K	Lrp/AsnC ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg
HKD2_k127_8007207_2	656024.FsymDg_3187	2.699e-143	467.0	COG0547@1|root,COG0547@2|Bacteria,2GM4G@201174|Actinobacteria,4ES7M@85013|Frankiales	201174|Actinobacteria	E	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)	trpD	GO:0000162,GO:0003674,GO:0003824,GO:0004048,GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0040007,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.4.2.18	ko:K00766	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R01073	RC00440	ko00000,ko00001,ko00002,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3
HKD2_k127_8007207_10	298655.KI912267_gene7425	9.978e-48	179.0	COG0784@1|root,COG0784@2|Bacteria,2II71@201174|Actinobacteria,4ET4B@85013|Frankiales	201174|Actinobacteria	T	response regulator	-	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Response_reg
HKD2_k127_8007207_8	222534.KB893711_gene4991	4.573e-53	189.0	COG0735@1|root,COG0735@2|Bacteria	2|Bacteria	P	belongs to the Fur family	-	-	-	ko:K03711,ko:K09825	-	-	-	-	ko00000,ko03000	-	-	-	FUR
HKD2_k127_8007207_7	298653.Franean1_1807	2.787e-75	258.0	COG1592@1|root,COG1592@2|Bacteria,2IJ63@201174|Actinobacteria	201174|Actinobacteria	C	PFAM Rubrerythrin	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
HKD2_k127_8007207_6	222534.KB893711_gene4993	4.012e-76	276.0	COG0247@1|root,COG0247@2|Bacteria,2GVNV@201174|Actinobacteria	201174|Actinobacteria	C	Protein of unknown function (DUF3501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3501
HKD2_k127_8007207_3	656024.FsymDg_3182	1.432e-129	439.0	COG3336@1|root,COG3336@2|Bacteria,2GKIR@201174|Actinobacteria,4ESB5@85013|Frankiales	201174|Actinobacteria	P	Cytochrome c oxidase caa3-type, assembly factor CtaG-related	-	-	-	ko:K02351,ko:K07245	-	-	-	-	ko00000,ko02000	9.B.62.1	-	-	Caa3_CtaG,CopD
HKD2_k127_8007207_4	656024.FsymDg_3181	1.447e-105	361.0	COG1845@1|root,COG1845@2|Bacteria,2GKK8@201174|Actinobacteria,4ESPW@85013|Frankiales	201174|Actinobacteria	C	PFAM cytochrome c oxidase, subunit III	ctaE	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	1.9.3.1	ko:K02276,ko:K02299	ko00190,ko01100,map00190,map01100	M00155,M00417	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.4,3.D.4.5,3.D.4.6	-	-	COX3
HKD2_k127_8007207_5	326424.FRAAL5111	6.318e-98	338.0	COG2010@1|root,COG2010@2|Bacteria,2GKUB@201174|Actinobacteria,4ESET@85013|Frankiales	201174|Actinobacteria	C	cytochrome C	qcrC	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	ko:K03889	ko00190,ko01100,map00190,map01100	M00151	-	-	ko00000,ko00001,ko00002	-	-	-	Cytochrome_CBB3
HKD2_k127_8007207_1	656024.FsymDg_3179	2.907e-149	501.0	COG0723@1|root,COG0723@2|Bacteria,2GIX6@201174|Actinobacteria,4ESQH@85013|Frankiales	201174|Actinobacteria	C	PFAM Rieske 2Fe-2S	-	-	-	ko:K03890	ko00190,ko01100,map00190,map01100	M00151	-	-	ko00000,ko00001,ko00002	-	-	-	Rieske
HKD2_k127_8007207_9	106370.Francci3_3105	1.449e-51	192.0	COG1290@1|root,COG1290@2|Bacteria,2GJ1E@201174|Actinobacteria,4ERM6@85013|Frankiales	201174|Actinobacteria	C	Cytochrome b	qcrB	-	-	ko:K03891	ko00190,ko01100,map00190,map01100	M00151	-	-	ko00000,ko00001,ko00002	-	-	-	Cytochrom_B_N_2
HKD2_k127_8036910_0	656024.FsymDg_2275	0.0	1217.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,2GM5Q@201174|Actinobacteria,4ERV9@85013|Frankiales	201174|Actinobacteria	E	Vitamin B12 dependent methionine synthase activation	metH	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008652,GO:0008705,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016741,GO:0019752,GO:0030312,GO:0032259,GO:0042084,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
HKD2_k127_8036910_20	298654.FraEuI1c_3762	1.529e-37	149.0	COG0637@1|root,COG0637@2|Bacteria,2GJNG@201174|Actinobacteria,4ETBP@85013|Frankiales	201174|Actinobacteria	S	subfamily IA, variant 3	hisE	-	-	-	-	-	-	-	-	-	-	-	HAD_2
HKD2_k127_8036910_27	585531.HMPREF0063_10758	3.103e-13	79.0	COG0637@1|root,COG0637@2|Bacteria,2GJNG@201174|Actinobacteria,4DQE5@85009|Propionibacteriales	201174|Actinobacteria	S	haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
HKD2_k127_8036910_17	208439.AJAP_16180	1.994e-68	252.0	COG4409@1|root,COG4409@2|Bacteria,2ICIA@201174|Actinobacteria,4EBQC@85010|Pseudonocardiales	201174|Actinobacteria	G	exo-alpha-(2->6)-sialidase activity	-	-	-	-	-	-	-	-	-	-	-	-	BNR_2
HKD2_k127_8036910_3	106370.Francci3_2636	6.947e-306	959.0	COG0577@1|root,COG0577@2|Bacteria,2GJTZ@201174|Actinobacteria,4EXBT@85013|Frankiales	201174|Actinobacteria	V	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HKD2_k127_8036910_13	656024.FsymDg_2232	7.891e-123	401.0	COG1136@1|root,COG1136@2|Bacteria,2GJN6@201174|Actinobacteria,4ES91@85013|Frankiales	201174|Actinobacteria	V	PFAM ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD2_k127_8036910_8	106370.Francci3_2634	4.066e-135	440.0	COG2887@1|root,COG2887@2|Bacteria,2GJC5@201174|Actinobacteria,4ERNB@85013|Frankiales	201174|Actinobacteria	L	PD-(D/E)XK nuclease superfamily	recB	-	-	ko:K07465	-	-	-	-	ko00000	-	-	-	PDDEXK_1
HKD2_k127_8036910_7	326424.FRAAL2866	1.208e-136	445.0	COG1994@1|root,COG1994@2|Bacteria,2GJBZ@201174|Actinobacteria,4ETEZ@85013|Frankiales	201174|Actinobacteria	S	Belongs to the peptidase M50B family	-	-	-	-	-	-	-	-	-	-	-	-	CBS,Peptidase_M50,Peptidase_M50B
HKD2_k127_8036910_9	222534.KB893705_gene5865	2.959e-133	463.0	COG2519@1|root,COG2519@2|Bacteria,2GJPD@201174|Actinobacteria,4ERZF@85013|Frankiales	201174|Actinobacteria	J	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA	trmI	GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016426,GO:0016429,GO:0016740,GO:0016741,GO:0030488,GO:0031515,GO:0032259,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0034708,GO:0043170,GO:0043412,GO:0043414,GO:0043527,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1990234	2.1.1.219,2.1.1.220	ko:K07442	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	GCD14,GCD14_N
HKD2_k127_8036910_23	219305.MCAG_05498	3.708e-31	125.0	COG1141@1|root,COG1141@2|Bacteria,2IKKX@201174|Actinobacteria,4DEYU@85008|Micromonosporales	201174|Actinobacteria	C	4Fe-4S single cluster domain of Ferredoxin I	-	-	-	ko:K05337	-	-	-	-	ko00000	-	-	-	Fer4_15
HKD2_k127_8036910_2	656024.FsymDg_2227	0.0	1080.0	COG1222@1|root,COG1222@2|Bacteria,2GMR1@201174|Actinobacteria,4ERPJ@85013|Frankiales	201174|Actinobacteria	O	ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis	arc	GO:0000302,GO:0000502,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010035,GO:0010498,GO:0010499,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019538,GO:0019941,GO:0022623,GO:0022624,GO:0030163,GO:0030312,GO:0032991,GO:0033554,GO:0034599,GO:0034614,GO:0035690,GO:0042221,GO:0042493,GO:0042802,GO:0043170,GO:0043335,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044424,GO:0044464,GO:0044877,GO:0050896,GO:0051409,GO:0051603,GO:0051704,GO:0051716,GO:0070628,GO:0070887,GO:0071241,GO:0071704,GO:0071731,GO:0071732,GO:0071944,GO:0097366,GO:0140030,GO:0140035,GO:1901564,GO:1901565,GO:1901575,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902170,GO:1902494,GO:1905368,GO:1905369	-	ko:K13527	ko03050,map03050	M00342	-	-	ko00000,ko00001,ko00002,ko03051	-	-	-	AAA,Prot_ATP_ID_OB
HKD2_k127_8036910_6	1382306.JNIM01000001_gene221	6.128e-165	524.0	COG0627@1|root,COG0627@2|Bacteria	2|Bacteria	J	Serine hydrolase involved in the detoxification of formaldehyde	-	-	-	-	-	-	-	-	-	-	-	-	Esterase
HKD2_k127_8036910_4	298653.Franean1_4881	3.261e-295	912.0	COG4122@1|root,COG4122@2|Bacteria,2GJGI@201174|Actinobacteria,4ERN8@85013|Frankiales	201174|Actinobacteria	S	Pup-ligase protein	dop	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006464,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0010498,GO:0016787,GO:0016810,GO:0016811,GO:0017076,GO:0018193,GO:0018205,GO:0019538,GO:0019941,GO:0030163,GO:0030554,GO:0032446,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0036211,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0051603,GO:0070490,GO:0070647,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575	3.5.1.119	ko:K20814	-	-	-	-	ko00000,ko01000,ko03051	-	-	-	Pup_ligase
HKD2_k127_8036910_21	1380393.JHVP01000009_gene1412	2.331e-36	156.0	2CIBE@1|root,32S7P@2|Bacteria,2IRU5@201174|Actinobacteria,4ET6C@85013|Frankiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8036910_25	656024.FsymDg_2225	2.111e-24	108.0	2E9C2@1|root,333JS@2|Bacteria,2IQ5V@201174|Actinobacteria,4ET8W@85013|Frankiales	201174|Actinobacteria	O	Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation	pup	GO:0003674,GO:0005488,GO:0006464,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0010498,GO:0018193,GO:0018205,GO:0019538,GO:0019941,GO:0030163,GO:0031386,GO:0032446,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044877,GO:0051603,GO:0070490,GO:0070628,GO:0070647,GO:0071704,GO:1901564,GO:1901565,GO:1901575	-	ko:K13570	-	-	-	-	ko00000,ko04121	-	-	-	Pup
HKD2_k127_8036910_11	656024.FsymDg_2223	7.779e-126	409.0	COG0638@1|root,COG0638@2|Bacteria,2GJ60@201174|Actinobacteria,4ES3U@85013|Frankiales	201174|Actinobacteria	O	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation	prcB	GO:0000502,GO:0005575,GO:0005622,GO:0005623,GO:0005839,GO:0019774,GO:0032991,GO:0044424,GO:0044464,GO:1902494,GO:1905368,GO:1905369	3.4.25.1	ko:K03433	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome
HKD2_k127_8036910_15	365528.KB891102_gene4245	1.588e-109	359.0	COG0638@1|root,COG0638@2|Bacteria,2GKZ1@201174|Actinobacteria,4ES3P@85013|Frankiales	201174|Actinobacteria	O	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation	prcA	GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0004298,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005839,GO:0005886,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010498,GO:0016020,GO:0016787,GO:0019538,GO:0019773,GO:0019941,GO:0030163,GO:0030312,GO:0032991,GO:0040007,GO:0043170,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044424,GO:0044464,GO:0051603,GO:0051704,GO:0070003,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1905368,GO:1905369	3.4.25.1	ko:K03432	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome
HKD2_k127_8036910_16	710111.FraQA3DRAFT_0840	2.37e-89	302.0	COG0412@1|root,COG0412@2|Bacteria,2GNWB@201174|Actinobacteria	201174|Actinobacteria	Q	Dienelactone hydrolase	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
HKD2_k127_8036910_5	365528.KB891102_gene4242	1.496e-281	867.0	COG0638@1|root,COG0638@2|Bacteria,2GMC6@201174|Actinobacteria,4ERF9@85013|Frankiales	201174|Actinobacteria	F	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine	pafA	GO:0000166,GO:0000302,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006464,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010035,GO:0010498,GO:0016020,GO:0016740,GO:0016874,GO:0016879,GO:0016881,GO:0017076,GO:0018193,GO:0018205,GO:0019538,GO:0019787,GO:0019941,GO:0030163,GO:0030312,GO:0030554,GO:0032446,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0034599,GO:0034614,GO:0035639,GO:0035690,GO:0036094,GO:0036211,GO:0042221,GO:0042493,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044464,GO:0050896,GO:0051409,GO:0051603,GO:0051704,GO:0051716,GO:0070490,GO:0070647,GO:0070887,GO:0071241,GO:0071704,GO:0071731,GO:0071732,GO:0071944,GO:0097159,GO:0097366,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902170	6.3.1.19	ko:K13571	-	M00342	R11207	RC00090,RC00096	ko00000,ko00002,ko01000,ko03051	-	-	-	Pup_ligase
HKD2_k127_8036910_18	106370.Francci3_2611	8.432e-42	166.0	COG0545@1|root,COG0545@2|Bacteria,2IHQC@201174|Actinobacteria,4ET6T@85013|Frankiales	201174|Actinobacteria	O	Peptidyl-prolyl cis-trans isomerase	-	-	5.2.1.8	ko:K01802	-	-	-	-	ko00000,ko01000	-	-	-	FKBP_C
HKD2_k127_8036910_10	656024.FsymDg_2218	6.032e-128	416.0	COG2378@1|root,COG2378@2|Bacteria,2GM46@201174|Actinobacteria,4ESHU@85013|Frankiales	201174|Actinobacteria	K	WYL domain	pafB	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	ko:K13572,ko:K13573	-	-	-	-	ko00000,ko03051	-	-	-	WYL
HKD2_k127_8036910_14	326424.FRAAL2881	1.666e-121	414.0	COG2378@1|root,COG2378@2|Bacteria,2GMAU@201174|Actinobacteria,4ESDG@85013|Frankiales	201174|Actinobacteria	K	WYL domain	pafC	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	-	ko:K13573	-	-	-	-	ko00000,ko03051	-	-	-	WYL
HKD2_k127_8036910_26	656024.FsymDg_2211	1.08e-18	89.0	COG1826@1|root,COG1826@2|Bacteria,2GQQX@201174|Actinobacteria,4ETM8@85013|Frankiales	201174|Actinobacteria	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system	tatA	GO:0008150,GO:0040007	-	ko:K03116	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
HKD2_k127_8036910_12	106370.Francci3_2606	5.079e-123	406.0	COG0805@1|root,COG0805@2|Bacteria,2GJK8@201174|Actinobacteria,4ESEG@85013|Frankiales	201174|Actinobacteria	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides	tatC	GO:0003674,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009977,GO:0015031,GO:0015291,GO:0015399,GO:0015405,GO:0015450,GO:0015833,GO:0016020,GO:0022804,GO:0022857,GO:0022884,GO:0032991,GO:0033036,GO:0033281,GO:0034613,GO:0040007,GO:0042886,GO:0042887,GO:0043953,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098796,GO:0098797,GO:1904680	-	ko:K03118	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	TatC
HKD2_k127_8036910_1	1123322.KB904647_gene1742	0.0	1196.0	COG4581@1|root,COG4581@2|Bacteria,2GJEX@201174|Actinobacteria	201174|Actinobacteria	L	DEAD DEAH box helicase	helY	GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009056,GO:0009057,GO:0009987,GO:0016020,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019439,GO:0030312,GO:0034641,GO:0034655,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0070035,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:1901360,GO:1901361,GO:1901575	-	ko:K03727	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,DSHCT,Helicase_C,rRNA_proc-arch
HKD2_k127_8036910_24	525368.HMPREF0591_0397	2.355e-28	117.0	2EK4T@1|root,33DV8@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8036910_22	929712.KI912613_gene2708	5.759e-34	134.0	COG2026@1|root,COG2026@2|Bacteria,2GRQR@201174|Actinobacteria,4CTZK@84995|Rubrobacteria	84995|Rubrobacteria	DJ	ParE toxin of type II toxin-antitoxin system, parDE	-	-	-	-	-	-	-	-	-	-	-	-	ParE_toxin
HKD2_k127_8036910_19	1146883.BLASA_2168	4.263e-40	152.0	COG2161@1|root,COG2161@2|Bacteria,2GRC8@201174|Actinobacteria	201174|Actinobacteria	D	Antitoxin component of a toxin-antitoxin (TA) module	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
HKD2_k127_8036910_29	1137269.AZWL01000005_gene2156	1.603e-07	58.0	COG1848@1|root,COG1848@2|Bacteria,2GSP5@201174|Actinobacteria	201174|Actinobacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	-	-	-	-	-	-	-	-	-	PIN
HKD2_k127_8036910_30	419947.MRA_0588	1.018e-05	53.0	2BT89@1|root,32NDN@2|Bacteria,2HDWZ@201174|Actinobacteria	201174|Actinobacteria	S	Ribbon-helix-helix protein, copG family	-	GO:0008150,GO:0040008,GO:0045927,GO:0048518,GO:0050789,GO:0065007	-	-	-	-	-	-	-	-	-	-	RHH_1
HKD2_k127_8046412_3	656024.FsymDg_0523	1.154e-63	243.0	COG2951@1|root,COG2951@2|Bacteria,2GX49@201174|Actinobacteria,4ESWA@85013|Frankiales	201174|Actinobacteria	M	Membrane-bound lytic murein transglycosylase	-	-	-	-	-	-	-	-	-	-	-	-	SLT_2
HKD2_k127_8046412_0	106370.Francci3_3628	4.482e-279	867.0	COG0119@1|root,COG0119@2|Bacteria,2GKYT@201174|Actinobacteria,4ERX1@85013|Frankiales	201174|Actinobacteria	E	Belongs to the alpha-IPM synthase homocitrate synthase family	leuA2	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
HKD2_k127_8046412_2	298655.KI912267_gene6749	5.115e-103	338.0	COG0664@1|root,COG0664@2|Bacteria,2I7B7@201174|Actinobacteria,4EX9I@85013|Frankiales	201174|Actinobacteria	K	PFAM Cyclic nucleotide-binding	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Crp_2,cNMP_binding
HKD2_k127_8046412_4	710111.FraQA3DRAFT_5754	3.758e-50	183.0	COG2905@1|root,COG2905@2|Bacteria,2I1DS@201174|Actinobacteria,4ETM1@85013|Frankiales	201174|Actinobacteria	T	protein with CBS domains	-	-	-	-	-	-	-	-	-	-	-	-	CBS
HKD2_k127_8046412_1	656024.FsymDg_3753	4.815e-175	552.0	COG0115@1|root,COG0115@2|Bacteria,2GKJ1@201174|Actinobacteria,4EX6N@85013|Frankiales	201174|Actinobacteria	E	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family	ilvE	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
HKD2_k127_8046412_6	1449353.JQMQ01000005_gene4373	0.0005849	51.0	2DRKZ@1|root,33C8D@2|Bacteria,2GWR3@201174|Actinobacteria,2NJ08@228398|Streptacidiphilus	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8090827_3	298653.Franean1_0737	2.845e-47	189.0	COG1716@1|root,COG1716@2|Bacteria,2IPDW@201174|Actinobacteria,4ET33@85013|Frankiales	201174|Actinobacteria	T	Forkhead associated domain	-	-	-	-	-	-	-	-	-	-	-	-	FHA
HKD2_k127_8090827_2	222534.KB893670_gene3845	9.101e-60	216.0	2B2V3@1|root,31VFN@2|Bacteria,2IMTP@201174|Actinobacteria,4ESVC@85013|Frankiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8090827_0	365528.KB891208_gene2856	3.3e-249	787.0	COG2072@1|root,COG2072@2|Bacteria,2I3HA@201174|Actinobacteria,4EXCW@85013|Frankiales	201174|Actinobacteria	P	flavoprotein involved in K transport	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8090827_1	479431.Namu_1395	2.88e-88	323.0	COG0515@1|root,COG0515@2|Bacteria,2HUBD@201174|Actinobacteria,4EUEB@85013|Frankiales	201174|Actinobacteria	KLT	Protein tyrosine kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
HKD2_k127_8090827_4	365528.KB891178_gene4767	1.582e-06	49.0	COG5433@1|root,COG5433@2|Bacteria,2HYBN@201174|Actinobacteria,4EWGM@85013|Frankiales	201174|Actinobacteria	L	required for the transposition of insertion element IS2404	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_assoc
HKD2_k127_8091698_4	710421.Mycch_1209	5.493e-18	87.0	2AXEU@1|root,31HX8@2|Bacteria,2GPJY@201174|Actinobacteria,23ASF@1762|Mycobacteriaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8091698_3	222534.KB893670_gene3693	2.114e-117	397.0	COG1253@1|root,COG1253@2|Bacteria,2GJ8X@201174|Actinobacteria,4ES3K@85013|Frankiales	201174|Actinobacteria	S	CBS domain containing protein	ytfL	-	-	-	-	-	-	-	-	-	-	-	CBS,DUF21
HKD2_k127_8091698_0	1120934.KB894416_gene4082	5.257e-139	456.0	COG1253@1|root,COG1253@2|Bacteria,2GKN5@201174|Actinobacteria,4E14W@85010|Pseudonocardiales	201174|Actinobacteria	S	overlaps another CDS with the same product name	tlyC	-	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
HKD2_k127_8091698_1	106370.Francci3_3037	6.711e-138	450.0	COG3391@1|root,COG3391@2|Bacteria,2GK45@201174|Actinobacteria,4EUI2@85013|Frankiales	201174|Actinobacteria	S	40-residue YVTN family beta-propeller repeat	-	-	-	-	-	-	-	-	-	-	-	-	Lactonase
HKD2_k127_8091698_2	1120936.KB907208_gene698	1.745e-128	427.0	COG1820@1|root,COG1820@2|Bacteria,2GK1E@201174|Actinobacteria,4EFH6@85012|Streptosporangiales	201174|Actinobacteria	G	Amidohydrolase family	nagA	-	3.5.1.25	ko:K01443	ko00520,ko01130,map00520,map01130	-	R02059	RC00166,RC00300	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
HKD2_k127_8126831_1	106370.Francci3_3035	2.259e-72	250.0	COG1814@1|root,COG1814@2|Bacteria,2H2FT@201174|Actinobacteria,4EX7A@85013|Frankiales	201174|Actinobacteria	S	VIT family	-	-	-	-	-	-	-	-	-	-	-	-	VIT1
HKD2_k127_8126831_0	446465.Bfae_26440	1.237e-98	337.0	COG3464@1|root,COG3464@2|Bacteria,2GJK7@201174|Actinobacteria,4FDDD@85020|Dermabacteraceae	201174|Actinobacteria	L	Helix-turn-helix domain of transposase family ISL3	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_ISL3,HTH_Tnp_ISL3,zf-ISL3
HKD2_k127_8126831_2	1146883.BLASA_1432	2.257e-11	68.0	COG3328@1|root,COG3328@2|Bacteria,2H9CR@201174|Actinobacteria	201174|Actinobacteria	L	Evidence 2b Function of strongly homologous gene	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_mut
HKD2_k127_8131346_0	222534.KB893717_gene1923	1.737e-180	567.0	COG1061@1|root,COG1061@2|Bacteria,2GIR9@201174|Actinobacteria,4ES5M@85013|Frankiales	201174|Actinobacteria	L	type III restriction protein res subunit	ercc3	-	3.6.4.12	ko:K10843	ko03022,ko03420,map03022,map03420	M00290	-	-	ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	ERCC3_RAD25_C,Helicase_C_3,ResIII
HKD2_k127_8131346_2	479435.Kfla_0120	1.492e-48	183.0	COG1708@1|root,COG1708@2|Bacteria,2GUWM@201174|Actinobacteria,4DVAU@85009|Propionibacteriales	201174|Actinobacteria	S	Nucleotidyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_2
HKD2_k127_8131346_4	1229780.BN381_50045	9.802e-09	61.0	2E2ZZ@1|root,32Y0I@2|Bacteria,2IIJC@201174|Actinobacteria,3UXI1@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8131346_3	1146883.BLASA_0639	6.596e-19	87.0	COG1061@1|root,COG1061@2|Bacteria,2GIR9@201174|Actinobacteria,4ES5M@85013|Frankiales	201174|Actinobacteria	L	type III restriction protein res subunit	ercc3	-	3.6.4.12	ko:K10843	ko03022,ko03420,map03022,map03420	M00290	-	-	ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	ERCC3_RAD25_C,Helicase_C_3,ResIII
HKD2_k127_8131346_1	298653.Franean1_0292	1.831e-52	196.0	COG1396@1|root,COG1396@2|Bacteria,2GK3V@201174|Actinobacteria	201174|Actinobacteria	K	sequence-specific DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	HTH_31
HKD2_k127_8133345_4	91464.S7335_4816	0.0008668	42.0	COG0212@1|root,COG0212@2|Bacteria,1G2B2@1117|Cyanobacteria,1GYGQ@1129|Synechococcus	1117|Cyanobacteria	H	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8133345_1	1894.JOER01000010_gene2177	7.538e-78	287.0	COG1752@1|root,COG1752@2|Bacteria,2IAA5@201174|Actinobacteria	201174|Actinobacteria	S	Esterase of the alpha-beta hydrolase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Patatin
HKD2_k127_8133345_2	935863.AWZR01000001_gene1664	1.593e-30	141.0	COG1752@1|root,COG1752@2|Bacteria,1Q82E@1224|Proteobacteria,1RRUE@1236|Gammaproteobacteria,1X52B@135614|Xanthomonadales	135614|Xanthomonadales	S	Patatin-like phospholipase	-	-	-	-	-	-	-	-	-	-	-	-	Patatin
HKD2_k127_8133345_0	326424.FRAAL5087	2.204e-112	368.0	COG0204@1|root,COG0204@2|Bacteria,2GJ6V@201174|Actinobacteria,4ERMB@85013|Frankiales	201174|Actinobacteria	I	PFAM Phospholipid glycerol acyltransferase	plsC	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
HKD2_k127_8133345_3	1352941.M877_25495	3.653e-29	122.0	COG4753@1|root,COG4753@2|Bacteria,2I2VC@201174|Actinobacteria	201174|Actinobacteria	T	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8137799_3	1045009.AFXQ01000013_gene660	2.4e-82	287.0	COG4553@1|root,COG4553@2|Bacteria,2IDSN@201174|Actinobacteria	201174|Actinobacteria	I	Protein of unknown function (DUF3141)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3141
HKD2_k127_8137799_5	1123024.AUII01000006_gene4578	3.364e-37	142.0	COG4553@1|root,COG4553@2|Bacteria,2IDSN@201174|Actinobacteria,4E8YW@85010|Pseudonocardiales	201174|Actinobacteria	I	Protein of unknown function (DUF3141)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3141
HKD2_k127_8137799_4	1120936.KB907212_gene5298	4.848e-81	280.0	COG2050@1|root,COG2050@2|Bacteria,2HMKZ@201174|Actinobacteria,4EKXK@85012|Streptosporangiales	201174|Actinobacteria	Q	Thioesterase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT_3
HKD2_k127_8137799_8	656024.FsymDg_4160	3.465e-22	104.0	COG4118@1|root,COG4118@2|Bacteria	2|Bacteria	D	positive regulation of growth	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
HKD2_k127_8137799_7	78398.KS43_07930	3.249e-22	104.0	COG3311@1|root,COG3311@2|Bacteria,1RFU1@1224|Proteobacteria,1RYMB@1236|Gammaproteobacteria,1MR1X@122277|Pectobacterium	1236|Gammaproteobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8137799_6	1429046.RR21198_2565	2.135e-30	124.0	COG1396@1|root,COG1396@2|Bacteria,2IKVI@201174|Actinobacteria,4G2PM@85025|Nocardiaceae	201174|Actinobacteria	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
HKD2_k127_8137799_0	485913.Krac_4958	2.493e-226	711.0	COG3957@1|root,COG3957@2|Bacteria	2|Bacteria	G	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase	xfp	-	4.1.2.22,4.1.2.9	ko:K01621	ko00030,ko00710,ko01100,ko01120,map00030,map00710,map01100,map01120	-	R00761,R01621	RC00032,RC00226	ko00000,ko00001,ko01000	-	-	-	XFP,XFP_C,XFP_N
HKD2_k127_8137799_1	1382306.JNIM01000001_gene588	5.232e-136	463.0	COG3957@1|root,COG3957@2|Bacteria	2|Bacteria	G	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase	xfp	-	4.1.2.22,4.1.2.9	ko:K01621	ko00030,ko00710,ko01100,ko01120,map00030,map00710,map01100,map01120	-	R00761,R01621	RC00032,RC00226	ko00000,ko00001,ko01000	-	-	-	XFP,XFP_C,XFP_N
HKD2_k127_8137799_2	1144275.COCOR_05153	1.109e-89	322.0	COG0282@1|root,COG0282@2|Bacteria,1MW61@1224|Proteobacteria,42MJA@68525|delta/epsilon subdivisions,2WJBJ@28221|Deltaproteobacteria,2YUMX@29|Myxococcales	28221|Deltaproteobacteria	H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction	ackA	-	2.7.2.1	ko:K00925	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00315,R01353	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetate_kinase,XFP,XFP_C,XFP_N
HKD2_k127_8137799_9	526225.Gobs_2123	3.87e-17	84.0	COG3293@1|root,COG3293@2|Bacteria,2GMT0@201174|Actinobacteria,4EV5F@85013|Frankiales	201174|Actinobacteria	L	PFAM transposase IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF4096
HKD2_k127_8137799_10	1171373.PACID_03410	0.0002496	43.0	COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,2IAHV@201174|Actinobacteria,4DUEP@85009|Propionibacteriales	201174|Actinobacteria	L	Winged helix-turn helix	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_28,HTH_32,HTH_33
HKD2_k127_8154652_0	1211815.CBYP010000073_gene3660	1.396e-43	168.0	COG1470@1|root,COG1470@2|Bacteria,2GP8D@201174|Actinobacteria,4ET4R@85013|Frankiales	201174|Actinobacteria	S	Protein of unknown function (DUF3048) C-terminal domain	yerB	-	-	-	-	-	-	-	-	-	-	-	DUF3048,DUF3048_C
HKD2_k127_8154652_2	1122609.AUGT01000005_gene1704	2.302e-25	111.0	COG1917@1|root,COG1917@2|Bacteria,2IQI4@201174|Actinobacteria,4DRQ8@85009|Propionibacteriales	201174|Actinobacteria	S	conserved protein, contains double-stranded beta-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8154652_1	1123322.KB904713_gene5222	3.67e-35	138.0	COG3189@1|root,COG3189@2|Bacteria,2IQC0@201174|Actinobacteria	201174|Actinobacteria	K	Protein of unknown function, DUF488	-	-	-	-	-	-	-	-	-	-	-	-	DUF488
HKD2_k127_8174638_18	1120917.AQXM01000014_gene296	7.327e-05	51.0	COG2026@1|root,COG2026@2|Bacteria,2HRW4@201174|Actinobacteria,1WC46@1268|Micrococcaceae	201174|Actinobacteria	DJ	ParE toxin of type II toxin-antitoxin system, parDE	-	-	-	-	-	-	-	-	-	-	-	-	ParE_toxin
HKD2_k127_8174638_11	222534.KB893683_gene1182	3.651e-45	183.0	COG1807@1|root,COG1807@2|Bacteria,2H1H7@201174|Actinobacteria,4EW4Y@85013|Frankiales	201174|Actinobacteria	M	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8174638_0	2002.JOEQ01000037_gene4324	1.512e-210	659.0	COG1063@1|root,COG1063@2|Bacteria,2GISW@201174|Actinobacteria,4EFZC@85012|Streptosporangiales	201174|Actinobacteria	E	Alcohol dehydrogenase GroES-like domain	fdh	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_N_assoc,ADH_zinc_N
HKD2_k127_8174638_10	356851.JOAN01000022_gene2223	9.661e-66	234.0	COG5637@1|root,COG5637@2|Bacteria,2GP5P@201174|Actinobacteria,4DHPP@85008|Micromonosporales	201174|Actinobacteria	S	Polyketide cyclase / dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc
HKD2_k127_8174638_2	1283287.KB822577_gene3324	1.631e-155	500.0	COG0310@1|root,COG0310@2|Bacteria,2GK2U@201174|Actinobacteria,4DNYF@85009|Propionibacteriales	201174|Actinobacteria	P	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import	cbiM	-	-	ko:K02007	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	CbiM,PDGLE
HKD2_k127_8174638_6	675635.Psed_2326	1.135e-112	372.0	COG0619@1|root,COG0619@2|Bacteria	2|Bacteria	P	transmembrane transporter activity	cbiQ	GO:0000041,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0015675,GO:0016020,GO:0016021,GO:0030001,GO:0031224,GO:0032991,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1902494,GO:1902495,GO:1904949,GO:1990351	-	ko:K02007,ko:K02008	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	CbiQ
HKD2_k127_8174638_5	675635.Psed_2325	6.614e-118	386.0	COG1122@1|root,COG1122@2|Bacteria,2GJ0M@201174|Actinobacteria,4DYPQ@85010|Pseudonocardiales	201174|Actinobacteria	P	ATPases associated with a variety of cellular activities	-	-	-	ko:K02006,ko:K16784	ko02010,map02010	M00245,M00246,M00581	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.18,3.A.1.22,3.A.1.23,3.A.1.25.1	-	-	ABC_tran
HKD2_k127_8174638_12	1463853.JOHW01000008_gene818	1.379e-41	154.0	COG0491@1|root,COG0491@2|Bacteria,2GJ6X@201174|Actinobacteria	201174|Actinobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HKD2_k127_8174638_13	1463853.JOHW01000008_gene818	8.783e-29	125.0	COG0491@1|root,COG0491@2|Bacteria,2GJ6X@201174|Actinobacteria	201174|Actinobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HKD2_k127_8174638_9	298655.KI912266_gene5689	5.13e-90	301.0	COG1949@1|root,COG1949@2|Bacteria,2GJR7@201174|Actinobacteria,4ESF7@85013|Frankiales	201174|Actinobacteria	L	3'-to-5' exoribonuclease specific for small oligoribonucleotides	orn	GO:0000175,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0034641,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0140098,GO:1901360	-	ko:K13288	ko03008,map03008	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019	-	-	-	RNase_T
HKD2_k127_8174638_14	1121952.ATXT01000013_gene2490	1.305e-18	94.0	2DN17@1|root,32UV9@2|Bacteria,2I85M@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8174638_8	1003195.SCAT_4969	3.505e-95	317.0	COG0726@1|root,COG0726@2|Bacteria,2GMC2@201174|Actinobacteria	201174|Actinobacteria	G	PFAM Polysaccharide deacetylase	-	-	3.5.1.104	ko:K22278	-	-	-	-	ko00000,ko01000	-	-	-	Polysacc_deac_1
HKD2_k127_8174638_20	1463825.JNXC01000005_gene2397	0.0006046	45.0	COG0582@1|root,COG0582@2|Bacteria,2IHIW@201174|Actinobacteria,4E2P0@85010|Pseudonocardiales	201174|Actinobacteria	L	Phage integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_3,Phage_integrase
HKD2_k127_8174638_4	1236902.ANAS01000005_gene4980	3.952e-125	415.0	COG0582@1|root,COG0582@2|Bacteria,2GMMI@201174|Actinobacteria,4EIUU@85012|Streptosporangiales	201174|Actinobacteria	L	Phage integrase, N-terminal SAM-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_3,Phage_integrase
HKD2_k127_8174638_15	298655.KI912266_gene668	5.537e-17	81.0	COG3311@1|root,COG3311@2|Bacteria,2GZDC@201174|Actinobacteria	201174|Actinobacteria	K	regulatory protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8174638_16	365528.KB891239_gene6024	3.142e-16	79.0	COG3311@1|root,COG3311@2|Bacteria	2|Bacteria	K	DNA excision	-	-	-	-	-	-	-	-	-	-	-	-	HTH_17
HKD2_k127_8174638_3	365528.KB891239_gene6023	2.41e-149	480.0	28IM9@1|root,2Z8MS@2|Bacteria,2GIR6@201174|Actinobacteria,4EUY2@85013|Frankiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8174638_7	365528.KB891239_gene6016	6.776e-96	324.0	COG0242@1|root,COG0242@2|Bacteria,2INK9@201174|Actinobacteria	201174|Actinobacteria	J	peptide deformylase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8174638_1	326424.FRAAL5442	1.101e-158	510.0	2EYFP@1|root,33RPJ@2|Bacteria,2IBPH@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8185715_0	543632.JOJL01000010_gene7205	6.921e-229	716.0	COG1350@1|root,COG1350@2|Bacteria,2GP7D@201174|Actinobacteria,4DBN0@85008|Micromonosporales	201174|Actinobacteria	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB2	-	4.2.1.20	ko:K06001	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HKD2_k127_8185715_1	710111.FraQA3DRAFT_2882	2.14e-201	637.0	COG1233@1|root,COG1233@2|Bacteria,2GJAV@201174|Actinobacteria,4ETTQ@85013|Frankiales	201174|Actinobacteria	Q	Flavin containing amine oxidoreductase	crtI2	-	5.4.99.9	ko:K01854	ko00052,ko00520,map00052,map00520	-	R00505,R09009	RC00317,RC02396	ko00000,ko00001,ko01000	-	-	-	Amino_oxidase
HKD2_k127_8185715_2	298653.Franean1_6225	9.961e-86	306.0	COG2208@1|root,COG2208@2|Bacteria,2GK8P@201174|Actinobacteria	201174|Actinobacteria	T	protein phosphatase 2C domain protein	prpE2	-	-	ko:K11928	-	-	-	-	ko00000,ko02000	2.A.21.2	-	-	GAF,GAF_2,HATPase_c_2,PAS,PAS_4,PAS_8,PAS_9,SpoIIE,sCache_3_2
HKD2_k127_8187335_19	298655.KI912266_gene4401	1.807e-11	69.0	COG1983@1|root,COG1983@2|Bacteria,2GIVS@201174|Actinobacteria,4EW85@85013|Frankiales	201174|Actinobacteria	KT	PFAM PspC domain protein	pspC	-	-	-	-	-	-	-	-	-	-	-	DUF2154,PspC
HKD2_k127_8187335_8	1157637.KB892113_gene4767	2.146e-102	348.0	COG1983@1|root,COG4585@1|root,COG1983@2|Bacteria,COG4585@2|Bacteria,2GJ4J@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase	tcsS3	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HATPase_c_2,PspC
HKD2_k127_8187335_10	1136417.AZWE01000012_gene2547	5.184e-88	304.0	COG2197@1|root,COG2197@2|Bacteria,2GIVA@201174|Actinobacteria,4D9AV@85008|Micromonosporales	201174|Actinobacteria	T	response regulator	tcsR3	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HKD2_k127_8187335_4	106370.Francci3_3809	2.531e-207	675.0	COG0513@1|root,COG0513@2|Bacteria,2GIUR@201174|Actinobacteria,4ERIC@85013|Frankiales	201174|Actinobacteria	L	Belongs to the DEAD box helicase family	rhlE	-	3.6.4.13	ko:K11927	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DEAD,Helicase_C
HKD2_k127_8187335_12	656024.FsymDg_0897	1.451e-76	286.0	COG3396@1|root,COG3396@2|Bacteria,2GKXZ@201174|Actinobacteria,4ESQ2@85013|Frankiales	201174|Actinobacteria	S	tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE)-like	-	-	-	-	-	-	-	-	-	-	-	-	MiaE_2
HKD2_k127_8187335_16	656024.FsymDg_0898	5.958e-26	108.0	2E3M2@1|root,32YJA@2|Bacteria,2GQQW@201174|Actinobacteria,4ETF4@85013|Frankiales	201174|Actinobacteria	S	Protein of unknown function (DUF3107)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3107
HKD2_k127_8187335_9	656024.FsymDg_0899	1.634e-88	297.0	COG1309@1|root,COG1309@2|Bacteria,2GVM5@201174|Actinobacteria,4ESNE@85013|Frankiales	201174|Actinobacteria	K	PFAM regulatory protein TetR	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
HKD2_k127_8187335_15	222534.KB893750_gene4371	3.385e-28	121.0	2E388@1|root,32Y7X@2|Bacteria,2GQYZ@201174|Actinobacteria,4ETH9@85013|Frankiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8187335_7	326424.FRAAL6052	4.54e-113	387.0	COG1273@1|root,COG1273@2|Bacteria,2GJMU@201174|Actinobacteria,4ERT1@85013|Frankiales	201174|Actinobacteria	L	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD	ku	-	-	ko:K10979	ko03450,map03450	-	-	-	ko00000,ko00001,ko03400	-	-	-	Ku
HKD2_k127_8187335_17	479435.Kfla_0904	4.477e-15	78.0	COG3237@1|root,COG3237@2|Bacteria,2I0D5@201174|Actinobacteria,4DSKR@85009|Propionibacteriales	201174|Actinobacteria	S	Belongs to the UPF0337 (CsbD) family	-	-	-	-	-	-	-	-	-	-	-	-	CsbD
HKD2_k127_8187335_2	106370.Francci3_3803	1.324e-225	712.0	COG0476@1|root,COG0607@1|root,COG0476@2|Bacteria,COG0607@2|Bacteria,2GJB6@201174|Actinobacteria,4ERNR@85013|Frankiales	201174|Actinobacteria	HP	PFAM UBA THIF-type NAD FAD binding	moeB	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008146,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009605,GO:0009607,GO:0009987,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0016782,GO:0019344,GO:0019752,GO:0020012,GO:0030312,GO:0030682,GO:0042783,GO:0043207,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051805,GO:0051807,GO:0051810,GO:0051832,GO:0051834,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0071704,GO:0071944,GO:0075136,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.7.80,2.8.1.11	ko:K21147	ko04122,map04122	-	R07459,R07461	RC00043	ko00000,ko00001,ko01000	-	-	-	Rhodanese,ThiF
HKD2_k127_8187335_14	106370.Francci3_3802	1.042e-44	181.0	COG3695@1|root,COG3695@2|Bacteria,2GQMD@201174|Actinobacteria,4ETMB@85013|Frankiales	201174|Actinobacteria	L	PFAM Methylated-DNA- protein -cysteine S-methyltransferase, DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	DNA_binding_1
HKD2_k127_8187335_13	65497.JODV01000003_gene4622	2.153e-49	189.0	COG0546@1|root,COG0546@2|Bacteria,2GNCU@201174|Actinobacteria,4E2IK@85010|Pseudonocardiales	201174|Actinobacteria	S	HAD-hyrolase-like	-	-	-	-	-	-	-	-	-	-	-	-	HAD,HAD_2,Hydrolase_like
HKD2_k127_8187335_1	1298863.AUEP01000007_gene318	7.787e-268	862.0	COG0210@1|root,COG2887@1|root,COG0210@2|Bacteria,COG2887@2|Bacteria,2GJD0@201174|Actinobacteria,4DPY8@85009|Propionibacteriales	201174|Actinobacteria	L	Belongs to the helicase family. UvrD subfamily	uvrD3	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
HKD2_k127_8187335_0	656024.FsymDg_0907	0.0	1338.0	COG0210@1|root,COG2887@1|root,COG0210@2|Bacteria,COG2887@2|Bacteria,2GM2E@201174|Actinobacteria,4ES9T@85013|Frankiales	201174|Actinobacteria	L	Belongs to the helicase family. UvrD subfamily	uvrD2	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
HKD2_k127_8187335_11	222534.KB893670_gene3679	6.312e-77	272.0	COG3568@1|root,COG3568@2|Bacteria,2GP3V@201174|Actinobacteria,4EV2P@85013|Frankiales	201174|Actinobacteria	L	Endonuclease Exonuclease phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
HKD2_k127_8187335_6	298653.Franean1_0930	7.972e-117	388.0	COG2508@1|root,COG2508@2|Bacteria,2GR38@201174|Actinobacteria,4ESI5@85013|Frankiales	201174|Actinobacteria	QT	transcriptional regulator, PucR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_30
HKD2_k127_8187335_5	1137269.AZWL01000014_gene768	5.862e-125	412.0	COG1398@1|root,COG1398@2|Bacteria,2GJJF@201174|Actinobacteria	201174|Actinobacteria	I	PFAM Fatty acid desaturase	-	-	1.14.19.1	ko:K00507	ko01040,ko01212,ko03320,ko04152,ko04212,map01040,map01212,map03320,map04152,map04212	-	R02222	RC00917	ko00000,ko00001,ko01000,ko01004	-	-	-	FA_desaturase
HKD2_k127_8187335_3	656024.FsymDg_0914	2.228e-208	689.0	COG0612@1|root,COG0612@2|Bacteria,2GJZ3@201174|Actinobacteria,4ERZ0@85013|Frankiales	201174|Actinobacteria	S	PFAM Peptidase M16	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
HKD2_k127_8194686_2	1380356.JNIK01000016_gene3661	3.194e-20	96.0	2E9QE@1|root,333WR@2|Bacteria,2I2DC@201174|Actinobacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8194686_1	710111.FraQA3DRAFT_3281	1.071e-130	430.0	COG1807@1|root,COG1807@2|Bacteria,2IITJ@201174|Actinobacteria	201174|Actinobacteria	M	Evidence 5 No homology to any previously reported sequences	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HKD2_k127_8194686_0	326424.FRAAL1777	1.724e-154	509.0	COG1835@1|root,COG2755@1|root,COG1835@2|Bacteria,COG2755@2|Bacteria,2GKI5@201174|Actinobacteria	201174|Actinobacteria	I	Acyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
HKD2_k127_8214839_12	47716.JOFH01000049_gene3280	3.942e-26	109.0	COG2331@1|root,COG2331@2|Bacteria,2GR6C@201174|Actinobacteria	201174|Actinobacteria	S	Regulatory protein, FmdB family	-	-	-	-	-	-	-	-	-	-	-	-	Zn-ribbon_8
HKD2_k127_8214839_8	469383.Cwoe_0966	2.711e-60	223.0	COG0842@1|root,COG0842@2|Bacteria,2HG4S@201174|Actinobacteria,4CQ73@84995|Rubrobacteria	84995|Rubrobacteria	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
HKD2_k127_8214839_9	105420.BBPO01000003_gene1142	3.416e-53	201.0	COG1131@1|root,COG1131@2|Bacteria,2GKI7@201174|Actinobacteria,2NFU5@228398|Streptacidiphilus	201174|Actinobacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
HKD2_k127_8214839_7	479434.Sthe_0431	2.594e-63	230.0	COG1131@1|root,COG1131@2|Bacteria,2G68Y@200795|Chloroflexi	200795|Chloroflexi	V	Domain of unknown function (DUF4162)	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
HKD2_k127_8214839_6	479434.Sthe_0432	9.135e-67	252.0	COG1695@1|root,COG1695@2|Bacteria,2G9FP@200795|Chloroflexi	200795|Chloroflexi	K	PFAM transcriptional regulator PadR family protein	-	-	-	-	-	-	-	-	-	-	-	-	PadR
HKD2_k127_8214839_5	1123320.KB889743_gene5122	2.012e-81	290.0	COG0627@1|root,COG0627@2|Bacteria,2GP6Q@201174|Actinobacteria	201174|Actinobacteria	S	Esterase	-	-	-	-	-	-	-	-	-	-	-	-	Esterase
HKD2_k127_8214839_13	479433.Caci_0079	1.049e-22	113.0	COG0627@1|root,COG0627@2|Bacteria	2|Bacteria	J	Serine hydrolase involved in the detoxification of formaldehyde	-	-	-	-	-	-	-	-	-	-	-	-	DUF5011,Esterase
HKD2_k127_8214839_1	1463909.KL585946_gene1290	1.051e-157	538.0	COG0709@1|root,COG0709@2|Bacteria,2GNP4@201174|Actinobacteria	201174|Actinobacteria	E	Synthesizes selenophosphate from selenide and ATP	selD	-	2.7.9.3	ko:K01008	ko00450,ko01100,map00450,map01100	-	R03595	RC00002,RC02878	ko00000,ko00001,ko01000,ko03016	-	-	-	AIRS,AIRS_C
HKD2_k127_8214839_0	1449976.KALB_8551	3.045e-285	897.0	COG5001@1|root,COG5002@1|root,COG5001@2|Bacteria,COG5002@2|Bacteria,2GIZF@201174|Actinobacteria,4DYN9@85010|Pseudonocardiales	201174|Actinobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS,PAS_3,PAS_4,PAS_9
HKD2_k127_8214839_2	455632.SGR_909	2.166e-139	458.0	COG4424@1|root,COG4424@2|Bacteria,2IEBG@201174|Actinobacteria	201174|Actinobacteria	S	Sulfotransferase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_3
HKD2_k127_8214839_3	1463936.JOJI01000031_gene2184	1.035e-106	361.0	COG1834@1|root,COG1834@2|Bacteria	2|Bacteria	E	dimethylargininase activity	-	-	3.5.3.6	ko:K01478	ko00220,ko01100,ko01110,ko01130,map00220,map01100,map01110,map01130	-	R00552	RC00177	ko00000,ko00001,ko01000	-	-	-	Amidinotransf
HKD2_k127_8214839_4	1283283.ATXA01000004_gene4428	1.688e-90	304.0	COG4221@1|root,COG4221@2|Bacteria,2GP05@201174|Actinobacteria	201174|Actinobacteria	L	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HKD2_k127_8214839_10	452652.KSE_32330	8.239e-44	181.0	COG0457@1|root,COG0457@2|Bacteria,2I9JN@201174|Actinobacteria	201174|Actinobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8214839_11	1415166.NONO_c18500	1.559e-27	113.0	COG3423@1|root,COG3423@2|Bacteria,2GP2G@201174|Actinobacteria,4G11B@85025|Nocardiaceae	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8268298_3	397278.JOJN01000002_gene356	1.045e-53	192.0	COG0181@1|root,COG0181@2|Bacteria,2GMWI@201174|Actinobacteria,4DN1M@85009|Propionibacteriales	201174|Actinobacteria	H	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps	hemC	GO:0003674,GO:0003824,GO:0004418,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0040007,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.61	ko:K01749	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00084	RC02317	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv0510	Porphobil_deam,Porphobil_deamC
HKD2_k127_8268298_0	365528.KB891252_gene5678	5.546e-192	619.0	COG0007@1|root,COG1587@1|root,COG0007@2|Bacteria,COG1587@2|Bacteria,2GMJZ@201174|Actinobacteria,4ERW5@85013|Frankiales	201174|Actinobacteria	H	Uroporphyrinogen III synthase HEM4	hemD	-	2.1.1.107,4.2.1.75	ko:K01719,ko:K13542	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R03165,R03194	RC00003,RC00871,RC01861	ko00000,ko00001,ko00002,ko01000	-	-	-	HEM4,TP_methylase
HKD2_k127_8268298_1	298654.FraEuI1c_6309	1.284e-147	499.0	COG0113@1|root,COG0113@2|Bacteria,2GJJ0@201174|Actinobacteria,4ERR7@85013|Frankiales	201174|Actinobacteria	H	Belongs to the ALAD family	hemB	GO:0003674,GO:0003824,GO:0004655,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0030312,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.2.1.24	ko:K01698	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00036	RC00918,RC01781	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ALAD
HKD2_k127_8268298_6	882082.SaccyDRAFT_5161	8.5e-08	63.0	2EQ4P@1|root,33HR0@2|Bacteria,2GTT9@201174|Actinobacteria,4E6JG@85010|Pseudonocardiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8268298_5	397278.JOJN01000003_gene1898	7.749e-21	103.0	COG5343@1|root,COG5343@2|Bacteria,2HU7G@201174|Actinobacteria,4DSM8@85009|Propionibacteriales	201174|Actinobacteria	S	Anti-sigma-K factor rskA	-	-	-	-	-	-	-	-	-	-	-	-	RskA
HKD2_k127_8268298_4	1283287.KB822576_gene3597	2.055e-43	176.0	COG1595@1|root,COG1595@2|Bacteria,2INGP@201174|Actinobacteria,4DUJ1@85009|Propionibacteriales	201174|Actinobacteria	K	Sigma-70, region 4	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
HKD2_k127_8268298_2	1380356.JNIK01000004_gene23	6.661e-57	217.0	arCOG06227@1|root,2ZCRG@2|Bacteria,2I96P@201174|Actinobacteria,4ETHW@85013|Frankiales	201174|Actinobacteria	S	Domain of unknown function (DUF4397)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4397
HKD2_k127_8282437_0	656024.FsymDg_3147	1.683e-83	284.0	2CPKU@1|root,32SJD@2|Bacteria,2I3ZF@201174|Actinobacteria,4ESNX@85013|Frankiales	201174|Actinobacteria	L	Exonuclease that cleaves single-stranded 3' overhangs of double-stranded RNA	-	GO:0003674,GO:0005488,GO:0005515,GO:0008150,GO:0040007,GO:0042802	-	-	-	-	-	-	-	-	-	-	DUF5051
HKD2_k127_8303209_3	1380356.JNIK01000016_gene3661	2.093e-77	281.0	2E9QE@1|root,333WR@2|Bacteria,2I2DC@201174|Actinobacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8303209_1	298655.KI912267_gene7066	3.999e-129	424.0	COG1835@1|root,COG1835@2|Bacteria,2GP6W@201174|Actinobacteria	201174|Actinobacteria	I	Acyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
HKD2_k127_8303209_2	287986.DV20_14155	6.008e-110	366.0	COG0500@1|root,COG2226@2|Bacteria,2GJSF@201174|Actinobacteria,4DX8P@85010|Pseudonocardiales	201174|Actinobacteria	Q	PFAM methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
HKD2_k127_8303209_0	326424.FRAAL1781	2.243e-276	864.0	COG0539@1|root,COG0539@2|Bacteria,2GJAK@201174|Actinobacteria,4ERN9@85013|Frankiales	201174|Actinobacteria	J	PFAM RNA binding S1 domain protein	rpsA	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
HKD2_k127_8303209_4	656024.FsymDg_2143	7.797e-66	246.0	COG0237@1|root,COG0237@2|Bacteria,2GN96@201174|Actinobacteria,4ESVT@85013|Frankiales	201174|Actinobacteria	H	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A	coaE	GO:0000166,GO:0001882,GO:0001884,GO:0002135,GO:0003674,GO:0003824,GO:0004140,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0018130,GO:0019103,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032549,GO:0032551,GO:0032552,GO:0032553,GO:0032554,GO:0032557,GO:0032558,GO:0032564,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.7.1.24	ko:K00859	ko00770,ko01100,map00770,map01100	M00120	R00130	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	CoaE,GrpB
HKD2_k127_8303209_5	1048339.KB913029_gene4503	1.619e-62	218.0	COG0556@1|root,COG0556@2|Bacteria,2GJ03@201174|Actinobacteria,4ERJA@85013|Frankiales	201174|Actinobacteria	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	GO:0002682,GO:0002684,GO:0005575,GO:0005623,GO:0005886,GO:0006950,GO:0008150,GO:0009605,GO:0009607,GO:0016020,GO:0035821,GO:0043207,GO:0044003,GO:0044403,GO:0044419,GO:0044464,GO:0048518,GO:0048583,GO:0048584,GO:0050776,GO:0050778,GO:0050789,GO:0050896,GO:0051409,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0052031,GO:0052173,GO:0052200,GO:0052255,GO:0052552,GO:0052553,GO:0052555,GO:0052556,GO:0052564,GO:0052572,GO:0065007,GO:0071944,GO:0075136	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
HKD2_k127_8326554_6	1121272.KB903251_gene848	1.353e-30	132.0	COG0702@1|root,COG0702@2|Bacteria,2GIZA@201174|Actinobacteria,4D8G8@85008|Micromonosporales	201174|Actinobacteria	GM	Protein of unknown function (DUF2867)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2867,NAD_binding_10
HKD2_k127_8326554_4	710111.FraQA3DRAFT_3189	9.275e-96	320.0	COG0702@1|root,COG0702@2|Bacteria,2GIZA@201174|Actinobacteria,4ESJH@85013|Frankiales	201174|Actinobacteria	GM	NAD-dependent epimerase dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	DUF2867,NAD_binding_10
HKD2_k127_8326554_2	656024.FsymDg_1487	1.39e-132	435.0	COG0668@1|root,COG0668@2|Bacteria,2GMFK@201174|Actinobacteria,4ES6X@85013|Frankiales	201174|Actinobacteria	M	mechanosensitive ion channel	mscS	-	-	ko:K22044	-	-	-	-	ko00000,ko02000	1.A.23.3	-	-	MS_channel
HKD2_k127_8326554_5	656024.FsymDg_1486	9.677e-88	291.0	COG1403@1|root,COG1403@2|Bacteria,2GN1W@201174|Actinobacteria,4ESID@85013|Frankiales	201174|Actinobacteria	L	PFAM HNH endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	HNH,HNH_5
HKD2_k127_8326554_0	477641.MODMU_1550	2.32e-165	540.0	COG0154@1|root,COG0154@2|Bacteria,2GKPZ@201174|Actinobacteria,4ESA4@85013|Frankiales	201174|Actinobacteria	J	Belongs to the amidase family	amiB	-	3.5.1.4	ko:K01426	ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120	-	R02540,R03096,R03180,R03909,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000	-	-	-	Amidase
HKD2_k127_8326554_7	1101188.KI912155_gene2549	3.355e-11	74.0	2DRJD@1|root,33C0U@2|Bacteria,2GU5N@201174|Actinobacteria,1WC7B@1268|Micrococcaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8326554_3	656024.FsymDg_1488	2.258e-114	373.0	COG0745@1|root,COG0745@2|Bacteria,2GIZB@201174|Actinobacteria,4ERZW@85013|Frankiales	201174|Actinobacteria	K	Two component transcriptional regulator, winged helix family	-	-	-	ko:K07669,ko:K07672	ko02020,map02020	M00460,M00463	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
HKD2_k127_8326554_1	656024.FsymDg_1489	1.67e-146	479.0	COG0642@1|root,COG2205@2|Bacteria,2GM17@201174|Actinobacteria,4ES13@85013|Frankiales	201174|Actinobacteria	T	signal transduction histidine kinase	-	-	2.7.13.3	ko:K07653	ko02020,map02020	M00460	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
HKD2_k127_8367443_3	1380346.JNIH01000002_gene6300	7.315e-55	196.0	COG1522@1|root,COG1522@2|Bacteria,2HA3J@201174|Actinobacteria	201174|Actinobacteria	K	AsnC family transcriptional regulator	-	-	-	ko:K03719	-	-	-	-	ko00000,ko03000,ko03036	-	-	-	AsnC_trans_reg,HTH_AsnC-type
HKD2_k127_8367443_2	656024.FsymDg_2927	2.405e-93	309.0	COG4636@1|root,COG4636@2|Bacteria,2I8SU@201174|Actinobacteria	201174|Actinobacteria	S	Putative restriction endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	Uma2
HKD2_k127_8367443_0	326424.FRAAL1010	2.853e-218	680.0	COG1060@1|root,COG1060@2|Bacteria,2GTIY@201174|Actinobacteria,4EUTK@85013|Frankiales	201174|Actinobacteria	H	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate	mqnE	GO:0003674,GO:0003824,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016740,GO:0016765,GO:0044237,GO:0044249,GO:0044689,GO:0051186,GO:0051188	2.5.1.120	ko:K18285	ko00130,ko01110,map00130,map01110	-	R10667	RC00021,RC03234	ko00000,ko00001,ko01000	-	-	-	Radical_SAM
HKD2_k127_8367443_1	1048339.KB913029_gene1708	8.074e-128	429.0	COG0827@1|root,COG0827@2|Bacteria,2I8PF@201174|Actinobacteria,4EUQW@85013|Frankiales	201174|Actinobacteria	L	N-6 DNA Methylase	-	-	-	-	-	-	-	-	-	-	-	-	N6_Mtase
HKD2_k127_8367443_4	216594.MMAR_1604	3.432e-44	164.0	COG0204@1|root,COG0204@2|Bacteria,2GNBB@201174|Actinobacteria,23691@1762|Mycobacteriaceae	201174|Actinobacteria	I	Acyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	DAGAT
HKD2_k127_8377070_1	222534.KB893714_gene1631	6.748e-182	573.0	COG0191@1|root,COG0191@2|Bacteria,2GM5P@201174|Actinobacteria,4ERVG@85013|Frankiales	201174|Actinobacteria	G	Fructose-bisphosphate aldolase, class II	fba	GO:0003674,GO:0003824,GO:0004332,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005996,GO:0006006,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016829,GO:0016830,GO:0016832,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0019899,GO:0030312,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035375,GO:0042866,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046872,GO:0046914,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576	4.1.2.13	ko:K01624	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167,M00344,M00345	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	F_bP_aldolase
HKD2_k127_8377070_0	477641.MODMU_2412	1.012e-213	672.0	COG0446@1|root,COG0446@2|Bacteria,2H7WY@201174|Actinobacteria,4ESDI@85013|Frankiales	201174|Actinobacteria	O	Pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,Pyr_redox_dim
HKD2_k127_8385662_9	512565.AMIS_78250	1.079e-24	103.0	2E3JZ@1|root,32YI8@2|Bacteria,2GQIX@201174|Actinobacteria,4DFIW@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4177
HKD2_k127_8385662_7	106370.Francci3_4282	6.018e-56	200.0	COG0251@1|root,COG0251@2|Bacteria,2IHNE@201174|Actinobacteria,4ESW4@85013|Frankiales	201174|Actinobacteria	J	endoribonuclease L-PSP	yabJ	-	-	-	-	-	-	-	-	-	-	-	YjgF_endoribonc
HKD2_k127_8385662_4	656024.FsymDg_1871	6.004e-89	305.0	COG0494@1|root,COG0494@2|Bacteria,2GN6D@201174|Actinobacteria,4ESRH@85013|Frankiales	201174|Actinobacteria	L	PFAM NUDIX hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
HKD2_k127_8385662_3	326424.FRAAL6554	2.284e-106	351.0	COG0491@1|root,COG0491@2|Bacteria,2GKP9@201174|Actinobacteria,4ESQS@85013|Frankiales	201174|Actinobacteria	S	beta-lactamase domain protein	pksB_1	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HKD2_k127_8385662_0	656024.FsymDg_4317	0.0	1361.0	COG0457@1|root,COG2114@1|root,COG3899@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG3899@2|Bacteria,2GJRI@201174|Actinobacteria	201174|Actinobacteria	T	Adenylyl cyclase class-3 4 guanylyl cyclase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,Guanylate_cyc,TPR_12
HKD2_k127_8385662_2	656024.FsymDg_4316	1.9e-116	378.0	COG0664@1|root,COG0664@2|Bacteria,2GMPN@201174|Actinobacteria,4ESG1@85013|Frankiales	201174|Actinobacteria	K	PFAM Cyclic nucleotide-binding	glxR	GO:0000166,GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006109,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010565,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0010675,GO:0016020,GO:0017076,GO:0019219,GO:0019222,GO:0030312,GO:0030551,GO:0030552,GO:0030554,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0032993,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043565,GO:0044212,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0062012,GO:0065007,GO:0071944,GO:0080090,GO:0097159,GO:0097367,GO:0140110,GO:1901265,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2000874,GO:2001141	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
HKD2_k127_8385662_1	298654.FraEuI1c_0335	9.661e-117	379.0	COG0177@1|root,COG0177@2|Bacteria,2GJ01@201174|Actinobacteria,4ERX8@85013|Frankiales	201174|Actinobacteria	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0030312,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD
HKD2_k127_8385662_5	1123320.KB889692_gene164	2.493e-78	286.0	COG0494@1|root,COG0494@2|Bacteria,2GKG9@201174|Actinobacteria	201174|Actinobacteria	L	NUDIX hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
HKD2_k127_8385662_8	106370.Francci3_4291	1.331e-30	125.0	COG3794@1|root,COG3794@2|Bacteria	2|Bacteria	C	PFAM blue (type 1) copper domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupredoxin_1
HKD2_k127_8385662_6	656024.FsymDg_4311	2.812e-64	224.0	COG0265@1|root,COG0265@2|Bacteria,2GJ92@201174|Actinobacteria,4EREG@85013|Frankiales	201174|Actinobacteria	O	Colicin V production protein	cvpA	GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0009268,GO:0009405,GO:0009628,GO:0010447,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044419,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051704,GO:0071944	-	-	-	-	-	-	-	-	-	-	Colicin_V,Trypsin_2
HKD2_k127_8410842_1	469371.Tbis_3062	1.851e-55	195.0	COG0012@1|root,COG0012@2|Bacteria,2GIXI@201174|Actinobacteria,4DYTA@85010|Pseudonocardiales	201174|Actinobacteria	J	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner	ychF	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,YchF-GTPase_C
HKD2_k127_8410842_4	391037.Sare_4425	8.518e-27	117.0	COG1487@1|root,COG1487@2|Bacteria,2IG0P@201174|Actinobacteria,4DE3Y@85008|Micromonosporales	201174|Actinobacteria	S	PIN domain	-	-	-	ko:K18828	-	-	-	-	ko00000,ko01000,ko02048,ko03016	-	-	-	PIN
HKD2_k127_8410842_7	391037.Sare_4424	3.662e-09	60.0	2B466@1|root,31WWY@2|Bacteria,2GY1Q@201174|Actinobacteria,4DGGY@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8410842_0	710111.FraQA3DRAFT_5494	2.017e-86	295.0	COG0122@1|root,COG0122@2|Bacteria	2|Bacteria	L	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase	alkA	-	4.2.99.18	ko:K03660	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD,OGG_N
HKD2_k127_8410842_5	656024.FsymDg_0830	6.051e-18	95.0	COG2154@1|root,COG2154@2|Bacteria,2GW4N@201174|Actinobacteria	201174|Actinobacteria	H	Pterin 4 alpha carbinolamine dehydratase	-	-	4.2.1.96	ko:K01724	ko00790,map00790	-	R04734	RC01208	ko00000,ko00001,ko01000,ko04147	-	-	-	DUF2267,Pterin_4a
HKD2_k127_8410842_2	298653.Franean1_0863	5.27e-42	160.0	COG0494@1|root,COG0494@2|Bacteria,2I2GY@201174|Actinobacteria,4ET93@85013|Frankiales	201174|Actinobacteria	L	Nudix hydrolase	mutT	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX
HKD2_k127_8410842_6	656024.FsymDg_0142	8.443e-18	84.0	2EMYS@1|root,33FKY@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF2795)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2795
HKD2_k127_8410842_3	58123.JOFJ01000004_gene1612	1.75e-28	125.0	COG1217@1|root,COG1217@2|Bacteria,2GJUJ@201174|Actinobacteria,4EFWD@85012|Streptosporangiales	201174|Actinobacteria	T	Elongation factor G C-terminus	typA	-	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2
HKD2_k127_8440548_0	106370.Francci3_0616	2.549e-86	289.0	COG1109@1|root,COG1109@2|Bacteria,2GN87@201174|Actinobacteria,4ERSE@85013|Frankiales	201174|Actinobacteria	G	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate	glmM	GO:0008150,GO:0040007	5.4.2.10	ko:K03431	ko00520,ko01100,ko01130,map00520,map01100,map01130	-	R02060	RC00408	ko00000,ko00001,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
HKD2_k127_8440548_2	710111.FraQA3DRAFT_3840	1.748e-61	214.0	COG0103@1|root,COG0103@2|Bacteria,2GNDY@201174|Actinobacteria,4ESQW@85013|Frankiales	201174|Actinobacteria	J	Belongs to the universal ribosomal protein uS9 family	rpsI	GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02996	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S9
HKD2_k127_8440548_1	106370.Francci3_0614	1.115e-70	248.0	COG0102@1|root,COG0102@2|Bacteria,2IFG1@201174|Actinobacteria,4ESPF@85013|Frankiales	201174|Actinobacteria	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly	rplM	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02871	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13
HKD2_k127_8440548_3	525904.Tter_1450	3.205e-37	148.0	2BVHN@1|root,32QW3@2|Bacteria	2|Bacteria	S	F420H(2)-dependent quinone reductase	-	-	-	-	-	-	-	-	-	-	-	-	F420H2_quin_red
HKD2_k127_8440548_4	326424.FRAAL1112	1.236e-31	124.0	COG0101@1|root,COG0101@2|Bacteria,2GJ6C@201174|Actinobacteria,4ESEA@85013|Frankiales	201174|Actinobacteria	J	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs	truA	GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016853,GO:0016866,GO:0030312,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:1901360	5.4.99.12	ko:K06173	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PseudoU_synth_1
HKD2_k127_8481385_4	298654.FraEuI1c_7145	6.033e-95	325.0	2DP6B@1|root,330Q3@2|Bacteria,2I3BG@201174|Actinobacteria,4EXCA@85013|Frankiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8481385_1	298654.FraEuI1c_7146	6.969e-265	834.0	28IJ8@1|root,2Z8K6@2|Bacteria,2GIV3@201174|Actinobacteria,4ET84@85013|Frankiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	EccE
HKD2_k127_8481385_0	298653.Franean1_7298	1.301e-270	839.0	COG3451@1|root,COG3451@2|Bacteria,2GM5W@201174|Actinobacteria,4ESK7@85013|Frankiales	201174|Actinobacteria	U	Evidence 4 Homologs of previously reported genes of	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8481385_3	656024.FsymDg_4500	3.666e-101	338.0	2DRTW@1|root,33D1H@2|Bacteria,2I99T@201174|Actinobacteria	201174|Actinobacteria	S	PFAM NERD domain protein	-	-	-	-	-	-	-	-	-	-	-	-	NERD
HKD2_k127_8481385_2	656024.FsymDg_4501	9.405e-141	468.0	COG3572@1|root,COG3572@2|Bacteria,2GJPI@201174|Actinobacteria,4ESKR@85013|Frankiales	201174|Actinobacteria	H	Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC). This compound is used as substrate for the biosynthesis of the low-molecular thiol compound ergothioneine	egtA	GO:0003674,GO:0003824,GO:0004357,GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0016874,GO:0016879,GO:0016881,GO:0044464,GO:0071944	6.3.2.2	ko:K01919	ko00270,ko00480,ko01100,map00270,map00480,map01100	M00118	R00894,R10993	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv3704c	GCS2
HKD2_k127_8507927_10	751945.Theos_0874	8.541e-07	61.0	COG1266@1|root,COG1266@2|Bacteria,1WK1W@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	CAAX amino terminal protease family	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
HKD2_k127_8507927_9	298653.Franean1_2078	5.152e-14	77.0	COG1612@1|root,COG1612@2|Bacteria,2GJQX@201174|Actinobacteria,4ESN0@85013|Frankiales	201174|Actinobacteria	O	cytochrome oxidase assembly	ctaA	-	-	ko:K02259	ko00190,ko00860,ko01100,ko01110,ko02020,ko04714,map00190,map00860,map01100,map01110,map02020,map04714	M00154	R07412	RC00769	ko00000,ko00001,ko00002,ko03029	3.D.4.4	-	-	COX15-CtaA
HKD2_k127_8507927_3	656024.FsymDg_1710	1.327e-103	355.0	COG0842@1|root,COG0842@2|Bacteria,2GN6S@201174|Actinobacteria,4ESTT@85013|Frankiales	201174|Actinobacteria	V	PFAM ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane,ABC2_membrane_3
HKD2_k127_8507927_2	656024.FsymDg_1711	1.258e-148	475.0	COG1131@1|root,COG1131@2|Bacteria,2GJBF@201174|Actinobacteria,4ETVV@85013|Frankiales	201174|Actinobacteria	V	PFAM ABC transporter	drrA_2	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD2_k127_8507927_5	1120949.KB903294_gene4706	9.653e-67	231.0	COG1695@1|root,COG1695@2|Bacteria,2GMJM@201174|Actinobacteria	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	PadR
HKD2_k127_8507927_1	1120949.KB903294_gene4707	7.294e-158	516.0	COG0477@1|root,COG0477@2|Bacteria,2I2QX@201174|Actinobacteria,4D8XI@85008|Micromonosporales	1120949.KB903294_gene4707|-	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8507927_8	419947.MRA_1572	2.96e-15	90.0	COG5450@1|root,COG5450@2|Bacteria,2GTYZ@201174|Actinobacteria,23BQF@1762|Mycobacteriaceae	201174|Actinobacteria	K	Bacterial antitoxin of type II TA system, VapB	-	GO:0006417,GO:0008150,GO:0009605,GO:0009607,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0034248,GO:0034250,GO:0040008,GO:0043207,GO:0044403,GO:0044419,GO:0045727,GO:0045927,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0051701,GO:0051704,GO:0051707,GO:0060255,GO:0065007,GO:0075136,GO:0080090,GO:2000112	-	-	-	-	-	-	-	-	-	-	VapB_antitoxin
HKD2_k127_8507927_7	1121877.JQKF01000012_gene319	4.894e-25	111.0	COG1487@1|root,COG1487@2|Bacteria,2ISE2@201174|Actinobacteria	201174|Actinobacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	GO:0003674,GO:0003824,GO:0004518,GO:0004540,GO:0006139,GO:0006417,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009605,GO:0009607,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0016070,GO:0016787,GO:0016788,GO:0017148,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0034641,GO:0040008,GO:0043170,GO:0043207,GO:0044237,GO:0044238,GO:0044403,GO:0044419,GO:0045926,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0051701,GO:0051704,GO:0051707,GO:0060255,GO:0065007,GO:0071704,GO:0075136,GO:0080090,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360,GO:2000112,GO:2000113	-	-	-	-	-	-	-	-	-	-	PIN
HKD2_k127_8507927_0	298655.KI912267_gene7015	5.219e-222	698.0	COG0554@1|root,COG0554@2|Bacteria,2GM13@201174|Actinobacteria,4EREP@85013|Frankiales	201174|Actinobacteria	C	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate	glpK	-	2.7.1.30	ko:K00864	ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626	-	R00847	RC00002,RC00017	ko00000,ko00001,ko01000,ko04147	-	-	-	FGGY_C,FGGY_N
HKD2_k127_8507927_6	298653.Franean1_2083	3.007e-32	134.0	2DRRW@1|root,33CSQ@2|Bacteria,2HU49@201174|Actinobacteria,4EWXU@85013|Frankiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8507927_4	656024.FsymDg_1713	6.226e-71	249.0	COG2345@1|root,COG2345@2|Bacteria,2GN8W@201174|Actinobacteria,4ESM6@85013|Frankiales	201174|Actinobacteria	K	Transcriptional regulator	sufR	-	-	-	-	-	-	-	-	-	-	-	HTH_11,HTH_20,HTH_24,HTH_5,MarR_2
HKD2_k127_8558930_1	222534.KB893715_gene1748	1.973e-181	587.0	COG1960@1|root,COG1960@2|Bacteria,2GMEM@201174|Actinobacteria,4ERC3@85013|Frankiales	201174|Actinobacteria	I	acyl-CoA dehydrogenase	fadE19	GO:0000062,GO:0000166,GO:0003674,GO:0003824,GO:0003995,GO:0004085,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005759,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0006950,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009605,GO:0009719,GO:0009725,GO:0009987,GO:0009991,GO:0010033,GO:0014070,GO:0016020,GO:0016042,GO:0016043,GO:0016054,GO:0016491,GO:0016627,GO:0017076,GO:0019395,GO:0019605,GO:0019626,GO:0019752,GO:0022607,GO:0030258,GO:0030554,GO:0031090,GO:0031667,GO:0031960,GO:0031966,GO:0031967,GO:0031974,GO:0031975,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0033218,GO:0033539,GO:0033993,GO:0034440,GO:0036094,GO:0042221,GO:0042594,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046359,GO:0046395,GO:0046459,GO:0048037,GO:0048545,GO:0050660,GO:0050662,GO:0050896,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0051384,GO:0052890,GO:0055114,GO:0065003,GO:0070013,GO:0071704,GO:0071840,GO:0072329,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901567,GO:1901575,GO:1901681	1.3.8.1,1.3.99.12	ko:K00248,ko:K11410	ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212	-	R01175,R01178,R02661,R03172,R04751	RC00052,RC00068,RC00076,RC00120,RC00148	ko00000,ko00001,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HKD2_k127_8558930_3	656024.FsymDg_1033	5.201e-65	231.0	COG2246@1|root,COG2246@2|Bacteria,2IFFV@201174|Actinobacteria,4ET34@85013|Frankiales	201174|Actinobacteria	S	PFAM GtrA family protein	-	-	-	-	-	-	-	-	-	-	-	-	GtrA
HKD2_k127_8558930_0	1122182.KB903813_gene2068	6.554e-258	804.0	COG4799@1|root,COG4799@2|Bacteria,2GIRU@201174|Actinobacteria,4DB7X@85008|Micromonosporales	201174|Actinobacteria	I	Carboxyl transferase domain	yngE	-	-	-	-	-	-	-	-	-	-	-	Carboxyl_trans
HKD2_k127_8558930_4	1123251.ATWM01000003_gene1147	1.19e-22	106.0	COG1487@1|root,COG1487@2|Bacteria,2IR5C@201174|Actinobacteria	201174|Actinobacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
HKD2_k127_8558930_2	479433.Caci_0816	4.685e-135	437.0	COG0119@1|root,COG0119@2|Bacteria,2GKTP@201174|Actinobacteria	201174|Actinobacteria	E	Hydroxymethylglutaryl-CoA lyase	mvaB	-	4.1.3.4	ko:K01640	ko00072,ko00280,ko00281,ko00650,ko01100,ko04146,map00072,map00280,map00281,map00650,map01100,map04146	M00036,M00088	R01360,R08090	RC00502,RC00503,RC01118,RC01946	ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like
HKD2_k127_8591346_12	680198.SCAB_11251	2.747e-10	61.0	COG3360@1|root,COG3360@2|Bacteria,2IQ6Z@201174|Actinobacteria	201174|Actinobacteria	S	Dodecin	-	-	-	ko:K09165	-	-	-	-	ko00000	-	-	-	Dodecin
HKD2_k127_8591346_7	1128421.JAGA01000002_gene503	3.22e-32	138.0	COG0537@1|root,COG0537@2|Bacteria,2NPE0@2323|unclassified Bacteria	2|Bacteria	FG	HIT domain	hit	-	-	ko:K02503	-	-	-	-	ko00000,ko04147	-	-	-	HIT
HKD2_k127_8591346_8	298654.FraEuI1c_4798	1.351e-24	109.0	COG2885@1|root,COG2885@2|Bacteria	2|Bacteria	M	chlorophyll binding	-	-	-	-	-	-	-	-	-	-	-	-	OmpA
HKD2_k127_8591346_10	710111.FraQA3DRAFT_0403	5.312e-19	95.0	COG2885@1|root,COG2885@2|Bacteria	2|Bacteria	M	chlorophyll binding	-	-	-	-	-	-	-	-	-	-	-	-	OmpA
HKD2_k127_8591346_0	298654.FraEuI1c_1888	1.811e-197	631.0	COG1404@1|root,COG1404@2|Bacteria,2GJ14@201174|Actinobacteria,4ETN2@85013|Frankiales	201174|Actinobacteria	O	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	CW_binding_1,Peptidase_S8
HKD2_k127_8591346_3	656024.FsymDg_1766	9.633e-139	445.0	COG0623@1|root,COG0623@2|Bacteria,2GJ65@201174|Actinobacteria,4ERER@85013|Frankiales	201174|Actinobacteria	I	Enoyl- acyl-carrier-protein reductase NADH	inhA	-	1.3.1.10,1.3.1.9	ko:K00208	ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212	M00083,M00572	R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671	RC00052,RC00076,RC00120	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HKD2_k127_8591346_5	1123320.KB889697_gene8851	3.113e-81	280.0	COG0596@1|root,COG0596@2|Bacteria,2GJDM@201174|Actinobacteria	201174|Actinobacteria	CH	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
HKD2_k127_8591346_4	656024.FsymDg_1770	3.179e-99	328.0	COG1028@1|root,COG1028@2|Bacteria,2GK6C@201174|Actinobacteria,4ERX3@85013|Frankiales	201174|Actinobacteria	IQ	Short-chain dehydrogenase reductase SDR	fabG1	GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004316,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009059,GO:0009273,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016746,GO:0016747,GO:0018454,GO:0019752,GO:0030497,GO:0032787,GO:0034645,GO:0036094,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046459,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0070402,GO:0070589,GO:0071554,GO:0071704,GO:0071766,GO:0071767,GO:0071768,GO:0071840,GO:0071944,GO:0072330,GO:0097159,GO:1901265,GO:1901363,GO:1901576	1.1.1.100	ko:K00059,ko:K11610	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HKD2_k127_8591346_6	1120792.JAFV01000001_gene380	3.955e-73	265.0	COG0061@1|root,COG0061@2|Bacteria,1MUBC@1224|Proteobacteria,2TSKN@28211|Alphaproteobacteria,36X67@31993|Methylocystaceae	28211|Alphaproteobacteria	G	ATP-NAD kinase	nadK	-	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	NAD_kinase
HKD2_k127_8591346_1	1120936.KB907211_gene83	6.229e-147	475.0	COG1304@1|root,COG1304@2|Bacteria,2GJA5@201174|Actinobacteria,4EIB7@85012|Streptosporangiales	201174|Actinobacteria	C	FMN-dependent dehydrogenase	lldA	-	1.13.12.4	ko:K00467	ko00620,map00620	-	R00319	RC01312	ko00000,ko00001,ko01000	-	-	-	FMN_dh
HKD2_k127_8591346_2	365528.KB891212_gene2289	3.601e-139	458.0	COG0276@1|root,COG0276@2|Bacteria,2GJTQ@201174|Actinobacteria,4ERHH@85013|Frankiales	201174|Actinobacteria	H	Catalyzes the ferrous insertion into protoporphyrin IX	hemH	GO:0003674,GO:0003824,GO:0004325,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016020,GO:0016829,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0040007,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0046148,GO:0046483,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051537,GO:0051540,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.99.1.1,4.99.1.9	ko:K01772	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R00310,R11329	RC01012	ko00000,ko00001,ko00002,ko01000	-	-	-	Ferrochelatase
HKD2_k127_8603036_2	304371.MCP_0389	1.016e-61	229.0	arCOG11014@1|root,arCOG11014@2157|Archaea,2XZ0A@28890|Euryarchaeota	2157|Archaea	S	Winged helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_42
HKD2_k127_8603036_0	479432.Sros_4198	3.804e-131	436.0	COG0604@1|root,COG0604@2|Bacteria,2GIS3@201174|Actinobacteria,4EJ1J@85012|Streptosporangiales	201174|Actinobacteria	C	Zinc-binding dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N_2
HKD2_k127_8603036_5	1157637.KB892090_gene6042	1.614e-07	58.0	2DR8X@1|root,33AQM@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K21495	-	-	-	-	ko00000,ko02048	-	-	-	-
HKD2_k127_8603036_3	1121017.AUFG01000035_gene694	3.819e-43	167.0	COG4113@1|root,COG4113@2|Bacteria,2GR4U@201174|Actinobacteria,4FHJX@85021|Intrasporangiaceae	201174|Actinobacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
HKD2_k127_8603036_1	469371.Tbis_1730	7.255e-90	307.0	COG4974@1|root,COG4974@2|Bacteria	2|Bacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_1,Phage_integrase
HKD2_k127_8617849_0	1236902.ANAS01000005_gene4929	1.005e-191	622.0	COG0475@1|root,COG0475@2|Bacteria,2I7Q8@201174|Actinobacteria,4ERA4@85012|Streptosporangiales	201174|Actinobacteria	P	Zn-finger in ubiquitin-hydrolases and other protein	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger,TrkA_N,zf-UBP
HKD2_k127_8617849_2	429009.Adeg_0241	7.887e-07	56.0	COG4113@1|root,COG4113@2|Bacteria,1VM2A@1239|Firmicutes,24WSR@186801|Clostridia,42I73@68295|Thermoanaerobacterales	186801|Clostridia	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
HKD2_k127_8617849_3	1121017.AUFG01000033_gene312	0.0002477	48.0	COG3585@1|root,COG3585@2|Bacteria,2IKQV@201174|Actinobacteria,4FGPS@85021|Intrasporangiaceae	201174|Actinobacteria	H	TOBE domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_17,MerR,TOBE
HKD2_k127_8617849_1	656024.FsymDg_0740	1.284e-106	353.0	COG1398@1|root,COG1398@2|Bacteria,2GJJF@201174|Actinobacteria,4ES37@85013|Frankiales	201174|Actinobacteria	I	Fatty acid desaturase	-	-	1.14.19.1	ko:K00507	ko01040,ko01212,ko03320,ko04152,ko04212,map01040,map01212,map03320,map04152,map04212	-	R02222	RC00917	ko00000,ko00001,ko01000,ko01004	-	-	-	FA_desaturase
HKD2_k127_8658220_0	1408433.JHXV01000002_gene381	5.667e-48	194.0	COG3631@1|root,COG3631@2|Bacteria	2|Bacteria	S	light absorption	-	-	-	ko:K06893	-	-	-	-	ko00000	-	-	-	SnoaL_2
HKD2_k127_8658220_1	471853.Bcav_4069	1.026e-42	168.0	COG1848@1|root,COG1848@2|Bacteria,2IJ89@201174|Actinobacteria	201174|Actinobacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	GO:0005575,GO:0005576	-	ko:K07064	-	-	-	-	ko00000	-	-	-	PIN
HKD2_k127_8669948_1	298653.Franean1_5166	5.363e-57	201.0	COG0296@1|root,COG0296@2|Bacteria,2GMIS@201174|Actinobacteria,4ES7Q@85013|Frankiales	201174|Actinobacteria	G	TIGRFAM malto-oligosyltrehalose trehalohydrolase	treZ	-	3.2.1.141	ko:K01236	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11256	RC00049	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48,DUF3459
HKD2_k127_8669948_0	1394178.AWOO02000129_gene1141	6.622e-106	355.0	COG0451@1|root,COG0451@2|Bacteria,2GNT1@201174|Actinobacteria,4EHEG@85012|Streptosporangiales	201174|Actinobacteria	GM	3-beta hydroxysteroid dehydrogenase/isomerase family	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
HKD2_k127_8682021_1	1146883.BLASA_4717	2.143e-51	183.0	COG0508@1|root,COG0508@2|Bacteria,2GM0D@201174|Actinobacteria,4ERC0@85013|Frankiales	201174|Actinobacteria	C	of components of various dehydrogenase complexes	pdhC	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
HKD2_k127_8682021_0	390989.JOEG01000010_gene543	1.234e-115	381.0	COG4977@1|root,COG4977@2|Bacteria,2GIRA@201174|Actinobacteria,4DC3D@85008|Micromonosporales	201174|Actinobacteria	K	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain	-	-	-	-	-	-	-	-	-	-	-	-	DJ-1_PfpI,HTH_18
HKD2_k127_8682021_4	106370.Francci3_2058	5.682e-06	48.0	COG5433@1|root,COG5433@2|Bacteria,2HYBN@201174|Actinobacteria,4EWGM@85013|Frankiales	201174|Actinobacteria	L	required for the transposition of insertion element IS2404	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_assoc
HKD2_k127_8704354_1	55952.BU52_21780	8.343e-225	701.0	COG5013@1|root,COG5013@2|Bacteria,2GKZU@201174|Actinobacteria	201174|Actinobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	narZ	-	1.7.5.1	ko:K00370	ko00910,ko01120,ko02020,map00910,map01120,map02020	M00529,M00530,M00804	R00798,R01106,R09497	RC02812	ko00000,ko00001,ko00002,ko01000	5.A.3.1	-	-	Molybdopterin,Molydop_binding
HKD2_k127_8704354_0	1463825.JNXC01000008_gene1268	5.221e-294	926.0	COG1140@1|root,COG1140@2|Bacteria,2GJ8P@201174|Actinobacteria,4DYH1@85010|Pseudonocardiales	201174|Actinobacteria	C	Nitrate reductase beta subunit	narH	-	1.7.5.1	ko:K00371	ko00910,ko01120,ko02020,map00910,map01120,map02020	M00529,M00530,M00804	R00798,R01106,R09497	RC02812	ko00000,ko00001,ko00002,ko01000	5.A.3.1	-	-	Fer4_11,Nitr_red_bet_C
HKD2_k127_8704354_4	1394178.AWOO02000040_gene8529	6.94e-60	234.0	COG2180@1|root,COG2180@2|Bacteria,2IAQV@201174|Actinobacteria,4EQWI@85012|Streptosporangiales	201174|Actinobacteria	C	Nitrate reductase delta subunit	narJ	-	-	ko:K00373	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	Nitrate_red_del
HKD2_k127_8704354_3	1048339.KB913029_gene2537	1.505e-110	375.0	COG2181@1|root,COG2181@2|Bacteria,2GJVI@201174|Actinobacteria,4ES4R@85013|Frankiales	201174|Actinobacteria	C	TIGRFAM respiratory nitrate reductase, gamma subunit	narI	-	1.7.5.1	ko:K00374	ko00910,ko01120,ko02020,map00910,map01120,map02020	M00529,M00530	R00798,R01106,R09497	RC02812	ko00000,ko00001,ko00002,ko01000	5.A.3.1	-	-	Nitrate_red_gam
HKD2_k127_8704354_2	106370.Francci3_1560	3.099e-156	512.0	COG3850@1|root,COG3850@2|Bacteria,2GIWI@201174|Actinobacteria,4ESAF@85013|Frankiales	201174|Actinobacteria	T	GAF domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HATPase_c_2,HisKA_3
HKD2_k127_8704354_5	106370.Francci3_1472	9.367e-38	150.0	COG1131@1|root,COG1131@2|Bacteria,2GIY8@201174|Actinobacteria,4ES16@85013|Frankiales	201174|Actinobacteria	V	TIGRFAM daunorubicin resistance ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
HKD2_k127_8718327_2	65497.JODV01000006_gene953	2.321e-42	162.0	COG0651@1|root,COG0651@2|Bacteria,2HAC7@201174|Actinobacteria,4DXG9@85010|Pseudonocardiales	201174|Actinobacteria	CP	Formate hydrogenlyase subunit 3 Multisubunit Na H antiporter, MnhD subunit	mnhD	-	-	ko:K05568	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Proton_antipo_M
HKD2_k127_8718327_4	443218.AS9A_0228	1.233e-18	98.0	COG1863@1|root,COG1863@2|Bacteria	2|Bacteria	P	multisubunit Na H antiporter MnhE subunit	mrpE	-	-	ko:K05569	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	MNHE
HKD2_k127_8718327_7	526225.Gobs_2932	7.2e-10	70.0	COG2212@1|root,COG2212@2|Bacteria,2H19H@201174|Actinobacteria	201174|Actinobacteria	P	Multiple resistance and pH regulation protein F (MrpF / PhaF)	-	-	-	ko:K05570	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	MrpF_PhaF
HKD2_k127_8718327_5	443218.AS9A_0226	1.039e-12	75.0	COG1320@1|root,COG1320@2|Bacteria,2GRNP@201174|Actinobacteria	201174|Actinobacteria	P	monovalent cation proton antiporter, MnhG PhaG subunit	-	-	-	ko:K05571	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	PhaG_MnhG_YufB
HKD2_k127_8718327_0	1211815.CBYP010000014_gene3470	1.675e-85	307.0	COG1503@1|root,COG1503@2|Bacteria	2|Bacteria	J	translation release factor activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8718327_3	1121924.ATWH01000011_gene403	8.418e-32	136.0	COG0346@1|root,COG0346@2|Bacteria,2IKTR@201174|Actinobacteria,4FPF8@85023|Microbacteriaceae	201174|Actinobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HKD2_k127_8718327_6	1121924.ATWH01000011_gene403	3.538e-10	68.0	COG0346@1|root,COG0346@2|Bacteria,2IKTR@201174|Actinobacteria,4FPF8@85023|Microbacteriaceae	201174|Actinobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HKD2_k127_8718327_1	219305.MCAG_04362	2.012e-48	179.0	COG1595@1|root,COG1595@2|Bacteria,2GMRK@201174|Actinobacteria,4DAPP@85008|Micromonosporales	201174|Actinobacteria	K	Sigma-70 region 2	sigG	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	NTF2,Sigma70_r2,Sigma70_r4_2,SnoaL_2
HKD2_k127_8719744_1	1313172.YM304_08840	1.593e-279	899.0	COG0449@1|root,COG0449@2|Bacteria,2GKH0@201174|Actinobacteria,4CN8H@84992|Acidimicrobiia	84992|Acidimicrobiia	M	Glutamine amidotransferase domain	glmS	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
HKD2_k127_8719744_3	675635.Psed_0559	8.779e-227	715.0	COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria,4DXDJ@85010|Pseudonocardiales	201174|Actinobacteria	IQ	AMP-binding enzyme C-terminal domain	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
HKD2_k127_8719744_4	290315.Clim_2497	1.879e-146	477.0	COG0427@1|root,COG0427@2|Bacteria,1FDQ1@1090|Chlorobi	1090|Chlorobi	C	PFAM acetyl-CoA hydrolase transferase	-	-	3.1.2.1	ko:K01067	ko00620,map00620	-	R00227	RC00004,RC00012	ko00000,ko00001,ko01000	-	-	-	AcetylCoA_hyd_C,AcetylCoA_hydro
HKD2_k127_8719744_6	656024.FsymDg_2533	1.638e-100	340.0	COG2310@1|root,COG2310@2|Bacteria,2GJ0Q@201174|Actinobacteria,4EU18@85013|Frankiales	201174|Actinobacteria	T	stress protein	-	-	-	ko:K05795	-	-	-	-	ko00000	-	-	-	TerD
HKD2_k127_8719744_10	1172179.AUKV01000006_gene6156	2.059e-73	263.0	COG2208@1|root,COG2208@2|Bacteria,2GK3Y@201174|Actinobacteria	201174|Actinobacteria	KT	Serine phosphatase RsbU, regulator of sigma subunit	-	-	-	-	-	-	-	-	-	-	-	-	SpoIIE
HKD2_k127_8719744_8	1223523.H340_11330	2.632e-86	292.0	COG1842@1|root,COG1842@2|Bacteria,2GP0K@201174|Actinobacteria	201174|Actinobacteria	KT	Phage shock protein A	pspA	-	-	ko:K03969	-	-	-	-	ko00000	-	-	-	PspA_IM30
HKD2_k127_8719744_13	1120936.KB907210_gene5879	1.056e-25	109.0	2E3Z4@1|root,32YW2@2|Bacteria,2IQZ7@201174|Actinobacteria,4EK4T@85012|Streptosporangiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8719744_5	298653.Franean1_2532	2.378e-125	412.0	COG0501@1|root,COG0501@2|Bacteria,2GMJF@201174|Actinobacteria,4EUCH@85013|Frankiales	201174|Actinobacteria	O	Peptidase family M48	htpX	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
HKD2_k127_8719744_11	479432.Sros_2659	6.883e-68	238.0	arCOG04740@1|root,31PZA@2|Bacteria,2GP15@201174|Actinobacteria,4EIMY@85012|Streptosporangiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8719744_2	68170.KL590496_gene9344	3.385e-261	820.0	COG0531@1|root,COG0531@2|Bacteria,2GIWQ@201174|Actinobacteria,4DYNN@85010|Pseudonocardiales	201174|Actinobacteria	E	Amino acid permease	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
HKD2_k127_8719744_12	1463887.KL589992_gene359	2.248e-67	239.0	COG2186@1|root,COG2186@2|Bacteria,2HQFA@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	-	-	-	ko:K05799	-	-	-	-	ko00000,ko03000	-	-	-	FCD,GntR
HKD2_k127_8719744_0	1003195.SCAT_0704	0.0	1428.0	COG0403@1|root,COG1003@1|root,COG0403@2|Bacteria,COG1003@2|Bacteria,2GJ11@201174|Actinobacteria	201174|Actinobacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvP	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	1.4.4.2	ko:K00281,ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko00002,ko01000	-	-	-	GDC-P
HKD2_k127_8719744_16	1223543.GP2_024_00220	4.833e-22	97.0	2E3V5@1|root,32YSE@2|Bacteria,2GQM1@201174|Actinobacteria,4GEVZ@85026|Gordoniaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	HTH_11,HTH_23,Sigma70_r4_2
HKD2_k127_8719744_14	2002.JOEQ01000007_gene1928	1.483e-24	114.0	COG0542@1|root,COG0542@2|Bacteria,2IRV0@201174|Actinobacteria,4EK23@85012|Streptosporangiales	201174|Actinobacteria	O	Clp amino terminal domain, pathogenicity island component	-	-	-	-	-	-	-	-	-	-	-	-	Clp_N
HKD2_k127_8719744_15	882083.SacmaDRAFT_1428	3.779e-22	100.0	2ESE5@1|root,33JYU@2|Bacteria,2IS59@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8719744_19	1122182.KB903813_gene2220	0.0002146	48.0	COG2161@1|root,COG2161@2|Bacteria,2HWXR@201174|Actinobacteria,4DKNB@85008|Micromonosporales	201174|Actinobacteria	D	Antitoxin Phd_YefM, type II toxin-antitoxin system	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
HKD2_k127_8719744_7	103733.JNYO01000001_gene40	4.569e-88	304.0	COG1024@1|root,COG1024@2|Bacteria,2GJG7@201174|Actinobacteria,4E2XE@85010|Pseudonocardiales	201174|Actinobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
HKD2_k127_8719744_9	994479.GL877879_gene5777	5.27e-83	288.0	COG3858@1|root,COG3858@2|Bacteria,2HZ7I@201174|Actinobacteria,4E92I@85010|Pseudonocardiales	201174|Actinobacteria	S	Glyco_18	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_18
HKD2_k127_8719744_17	414996.IL38_07650	3.963e-07	57.0	COG1215@1|root,COG1215@2|Bacteria,2I97V@201174|Actinobacteria,408RV@622450|Actinopolysporales	201174|Actinobacteria	M	Glycosyl transferase family group 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3,Glyco_trans_2_3,Glycos_transf_2
HKD2_k127_8802616_0	710111.FraQA3DRAFT_2859	2.238e-177	568.0	COG0771@1|root,COG0771@2|Bacteria,2GJZA@201174|Actinobacteria,4ERI0@85013|Frankiales	201174|Actinobacteria	M	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)	murD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464	6.3.2.9	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R02783	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	iNJ661.Rv2155c	AlaDh_PNT_C,Mur_ligase_C,Mur_ligase_M
HKD2_k127_8802616_1	222534.KB893671_gene3285	7.98e-141	462.0	COG0772@1|root,COG0772@2|Bacteria,2GKXP@201174|Actinobacteria,4ES9A@85013|Frankiales	201174|Actinobacteria	D	Belongs to the SEDS family	ftsW	GO:0008150,GO:0040007	2.4.1.227	ko:K02563,ko:K03588	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	-	R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011,ko02000,ko03036	2.A.103.1	GT28	-	FTSW_RODA_SPOVE
HKD2_k127_8815759_7	710111.FraQA3DRAFT_4834	2.501e-48	180.0	2B0VH@1|root,31T83@2|Bacteria,2H04D@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8815759_3	326424.FRAAL0045	2.156e-109	376.0	COG0741@1|root,COG0791@1|root,COG0741@2|Bacteria,COG0791@2|Bacteria,2GP5E@201174|Actinobacteria	201174|Actinobacteria	M	PFAM NLP P60 protein	-	-	-	-	-	-	-	-	-	-	-	-	NLPC_P60,Peptidase_M23,SLT,SLT_2
HKD2_k127_8815759_8	1206737.BAGF01000040_gene2358	2.221e-45	169.0	COG0071@1|root,COG0071@2|Bacteria,2IHVJ@201174|Actinobacteria,4G18Q@85025|Nocardiaceae	201174|Actinobacteria	O	Belongs to the small heat shock protein (HSP20) family	hsp18	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
HKD2_k127_8815759_5	67281.JNZZ01000006_gene5516	3.735e-88	304.0	COG4826@1|root,COG4826@2|Bacteria,2I99Q@201174|Actinobacteria,417K7@629295|Streptomyces griseus group	201174|Actinobacteria	O	SERine  Proteinase INhibitors	-	-	-	-	-	-	-	-	-	-	-	-	Serpin
HKD2_k127_8815759_4	485913.Krac_4785	6.341e-92	314.0	COG0697@1|root,COG0697@2|Bacteria,2G6ZR@200795|Chloroflexi	200795|Chloroflexi	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HKD2_k127_8815759_2	365528.KB891230_gene1969	1.901e-130	423.0	COG2141@1|root,COG2141@2|Bacteria,2GJTP@201174|Actinobacteria,4ESA9@85013|Frankiales	201174|Actinobacteria	C	F420-dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
HKD2_k127_8815759_1	479432.Sros_8974	5.427e-172	567.0	COG1071@1|root,COG1071@2|Bacteria,2GK3W@201174|Actinobacteria,4EG6N@85012|Streptosporangiales	201174|Actinobacteria	C	Dehydrogenase E1 component	pdhA	-	1.2.4.1,1.2.4.4	ko:K00161,ko:K00166	ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00036,M00307	R00014,R00209,R01699,R03270,R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00004,RC00027,RC00627,RC02742,RC02743,RC02744,RC02882,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
HKD2_k127_8815759_0	656024.FsymDg_4471	4.343e-172	545.0	COG0022@1|root,COG0022@2|Bacteria,2GKFE@201174|Actinobacteria,4ES0E@85013|Frankiales	201174|Actinobacteria	C	PFAM Transketolase central region	pdhB	-	1.2.4.1	ko:K00162	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
HKD2_k127_8815759_6	1120949.KB903340_gene8103	2.679e-58	224.0	COG0508@1|root,COG0508@2|Bacteria,2GM0D@201174|Actinobacteria,4D9AD@85008|Micromonosporales	201174|Actinobacteria	C	of components of various dehydrogenase complexes	pdhC	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
HKD2_k127_8827745_4	1380347.JNII01000007_gene331	5.974e-10	62.0	COG0671@1|root,COG0671@2|Bacteria	2|Bacteria	I	phosphatidate phosphatase activity	-	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	DUF3703,PAP2
HKD2_k127_8827745_2	1173020.Cha6605_0016	3.79e-35	156.0	COG2202@1|root,COG2203@1|root,COG3829@1|root,COG4251@1|root,COG2202@2|Bacteria,COG2203@2|Bacteria,COG3829@2|Bacteria,COG4251@2|Bacteria,1G0A1@1117|Cyanobacteria	2|Bacteria	T	PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	prpJ1	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008081,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009165,GO:0009166,GO:0009187,GO:0009190,GO:0009214,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042578,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0052621,GO:0055086,GO:0071111,GO:0071704,GO:0071944,GO:0090407,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576	3.1.3.3,4.6.1.1	ko:K01768,ko:K07315,ko:K11928	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000,ko02000,ko03021	2.A.21.2	-	-	GAF,GAF_2,HATPase_c_2,PAS,PAS_3,PAS_4,PAS_9,SpoIIE,sCache_3_2
HKD2_k127_8827745_0	2074.JNYD01000046_gene7295	3.524e-90	329.0	COG0642@1|root,COG2203@1|root,COG2208@1|root,COG2203@2|Bacteria,COG2205@2|Bacteria,COG2208@2|Bacteria,2GKN8@201174|Actinobacteria,4DZ1T@85010|Pseudonocardiales	201174|Actinobacteria	KT	Serine phosphatase RsbU, regulator of sigma subunit	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,SpoIIE
HKD2_k127_8827745_1	1380356.JNIK01000005_gene1052	8.59e-85	288.0	COG1309@1|root,COG1309@2|Bacteria,2GQRD@201174|Actinobacteria,4ETEK@85013|Frankiales	201174|Actinobacteria	K	transcriptional regulator, TetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C,TetR_N
HKD2_k127_8827745_3	710696.Intca_3501	3.241e-22	101.0	COG2026@1|root,COG2026@2|Bacteria,2GRQR@201174|Actinobacteria,4FJ7R@85021|Intrasporangiaceae	201174|Actinobacteria	DJ	ParE toxin of type II toxin-antitoxin system, parDE	-	-	-	-	-	-	-	-	-	-	-	-	ParE_toxin
HKD2_k127_8827745_5	1123024.AUII01000004_gene1500	2.798e-05	48.0	COG2161@1|root,COG2161@2|Bacteria,2HRW5@201174|Actinobacteria,4ECX5@85010|Pseudonocardiales	201174|Actinobacteria	D	Antitoxin component of a toxin-antitoxin (TA) module	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
HKD2_k127_8834430_6	298653.Franean1_3405	8.443e-18	84.0	COG1969@1|root,COG1969@2|Bacteria	2|Bacteria	C	respiratory electron transport chain	cybH	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006113,GO:0008150,GO:0008152,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0020037,GO:0031224,GO:0031226,GO:0032991,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0044569,GO:0045333,GO:0046906,GO:0048037,GO:0055114,GO:0071944,GO:0097159,GO:1901363,GO:1902494	-	ko:K03620	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	Ni_hydr_CYTB
HKD2_k127_8834430_3	298653.Franean1_3406	2.422e-38	153.0	COG0680@1|root,COG0680@2|Bacteria	2|Bacteria	C	spore germination	hybD	-	-	ko:K03605	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	HycI
HKD2_k127_8834430_5	365528.KB891214_gene2434	4.154e-22	104.0	COG0375@1|root,COG0375@2|Bacteria	2|Bacteria	S	nickel cation binding	-	-	-	ko:K04651	-	-	-	-	ko00000,ko03110	-	-	-	HypA
HKD2_k127_8834430_1	469383.Cwoe_1310	8.122e-106	357.0	COG2267@1|root,COG2267@2|Bacteria,2GJ78@201174|Actinobacteria,4CSBE@84995|Rubrobacteria	84995|Rubrobacteria	I	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
HKD2_k127_8834430_4	1128421.JAGA01000002_gene1259	1.816e-24	115.0	COG1525@1|root,COG1680@1|root,COG1525@2|Bacteria,COG1680@2|Bacteria,2NQ3M@2323|unclassified Bacteria	2|Bacteria	L	Staphylococcal nuclease homologues	-	-	3.1.31.1,3.4.16.4	ko:K01174,ko:K01286	-	-	-	-	ko00000,ko01000	-	-	-	Ada_Zn_binding,Beta-lactamase,SNase
HKD2_k127_8834430_2	106370.Francci3_0450	4.765e-42	164.0	2E36U@1|root,32Y6I@2|Bacteria,2IM2G@201174|Actinobacteria,4ETDN@85013|Frankiales	201174|Actinobacteria	S	Protein of unknown function (DUF1416)	sseC	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DUF1416
HKD2_k127_8834430_0	656024.FsymDg_4088	7.569e-153	488.0	COG2897@1|root,COG2897@2|Bacteria,2GIYU@201174|Actinobacteria,4ES5U@85013|Frankiales	201174|Actinobacteria	P	sulfurtransferase	cysA	-	2.8.1.1,2.8.1.2	ko:K01011	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko01000	-	-	-	Rhodanese
HKD2_k127_8899409_3	351607.Acel_0588	1.498e-102	344.0	COG0508@1|root,COG0508@2|Bacteria,2GN5J@201174|Actinobacteria,4EUGM@85013|Frankiales	201174|Actinobacteria	C	PFAM catalytic domain of components of various dehydrogenase complexes	-	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
HKD2_k127_8899409_4	235985.BBPN01000007_gene3271	3.121e-87	299.0	COG1307@1|root,COG1307@2|Bacteria,2GIUV@201174|Actinobacteria,2NFGN@228398|Streptacidiphilus	201174|Actinobacteria	S	Uncharacterised protein, DegV family COG1307	-	-	-	-	-	-	-	-	-	-	-	-	DegV
HKD2_k127_8899409_5	656024.FsymDg_1609	1.28e-71	256.0	COG1555@1|root,COG1555@2|Bacteria,2IQDC@201174|Actinobacteria,4ET14@85013|Frankiales	201174|Actinobacteria	L	helix-hairpin-helix	comEA	-	-	ko:K02237	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	HHH_3,SLBB
HKD2_k127_8899409_1	106370.Francci3_1258	2.459e-203	656.0	COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,2GJGR@201174|Actinobacteria,4ES7C@85013|Frankiales	201174|Actinobacteria	S	ComEC Rec2-related protein	comEC	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Competence,DUF4131,Lactamase_B
HKD2_k127_8899409_2	365528.KB891219_gene1090	1.366e-123	419.0	COG1466@1|root,COG1466@2|Bacteria,2GNMZ@201174|Actinobacteria,4ESK0@85013|Frankiales	201174|Actinobacteria	L	DNA polymerase III, delta subunit	holA	-	2.7.7.7	ko:K02340	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta
HKD2_k127_8899409_8	512565.AMIS_11610	1.793e-08	66.0	COG5263@1|root,COG5263@2|Bacteria	2|Bacteria	S	dextransucrase activity	-	-	-	ko:K03975,ko:K07126,ko:K13963,ko:K21012	ko02025,ko05146,map02025,map05146	-	-	-	ko00000,ko00001	-	-	-	GLTT,WG_beta_rep
HKD2_k127_8899409_7	298655.KI912266_gene5322	1.369e-30	123.0	COG0268@1|root,COG0268@2|Bacteria,2IQ73@201174|Actinobacteria,4ETD6@85013|Frankiales	201174|Actinobacteria	J	Binds directly to 16S ribosomal RNA	rpsT	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464	-	ko:K02968	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S20p
HKD2_k127_8899409_0	365528.KB891219_gene1093	0.0	1076.0	COG0481@1|root,COG0481@2|Bacteria,2GJAB@201174|Actinobacteria,4ERZ3@85013|Frankiales	201174|Actinobacteria	M	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner	lepA	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K03596	ko05134,map05134	-	-	-	ko00000,ko00001	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2,LepA_C
HKD2_k127_8899409_6	1521187.JPIM01000002_gene3155	1.575e-49	178.0	COG0698@1|root,COG0698@2|Bacteria,2G8SW@200795|Chloroflexi,377K0@32061|Chloroflexia	32061|Chloroflexia	G	TIGRFAM sugar-phosphate isomerase, RpiB LacA LacB family	-	-	5.3.1.6	ko:K01808	ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01056,R09030	RC00376,RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	LacAB_rpiB
HKD2_k127_8944806_1	211114.JOEF01000026_gene372	8.518e-58	211.0	COG1042@1|root,COG1042@2|Bacteria,2GKN1@201174|Actinobacteria,4DZ1D@85010|Pseudonocardiales	201174|Actinobacteria	C	CoA binding domain	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig
HKD2_k127_8944806_0	644966.Tmar_0901	3.253e-151	497.0	COG0045@1|root,COG1042@1|root,COG1670@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,COG1670@2|Bacteria,1TPTQ@1239|Firmicutes,249CX@186801|Clostridia,3WD0A@538999|Clostridiales incertae sedis	186801|Clostridia	C	TIGRFAM acetyl coenzyme A synthetase (ADP forming), alpha domain	-	-	6.2.1.13	ko:K01905,ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5,Acetyltransf_1,CoA_binding_2,Succ_CoA_lig
HKD2_k127_8959451_1	1068978.AMETH_1176	3.52e-114	374.0	COG1804@1|root,COG1804@2|Bacteria,2GKNX@201174|Actinobacteria,4DYUC@85010|Pseudonocardiales	201174|Actinobacteria	C	PFAM CoA-transferase family III	-	-	5.1.99.4	ko:K01796	ko00120,ko01100,ko04146,map00120,map01100,map04146	M00104	R08734,R08739	RC02345	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_transf_3
HKD2_k127_8959451_0	222534.KB893694_gene88	5.943e-169	538.0	COG1804@1|root,COG1804@2|Bacteria,2GIU7@201174|Actinobacteria,4EU47@85013|Frankiales	201174|Actinobacteria	C	CoA-transferase family III	-	-	2.8.3.16	ko:K07749	-	-	-	-	ko00000,ko01000	-	-	-	CoA_transf_3
HKD2_k127_8959451_2	710686.Mycsm_00854	2.156e-28	117.0	COG4113@1|root,COG4113@2|Bacteria,2GR4U@201174|Actinobacteria,239XI@1762|Mycobacteriaceae	201174|Actinobacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	-	-	-	-	-	-	-	-	-	PIN
HKD2_k127_8984639_1	298654.FraEuI1c_4202	5.133e-173	550.0	COG0183@1|root,COG0183@2|Bacteria,2GJAC@201174|Actinobacteria,4ESB2@85013|Frankiales	201174|Actinobacteria	I	Belongs to the thiolase family	-	-	2.3.1.16,2.3.1.9	ko:K00626,ko:K00632	ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00087,M00088,M00095,M00113,M00373,M00374,M00375	R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
HKD2_k127_8984639_0	1380347.JNII01000005_gene3058	5.654e-273	852.0	COG1960@1|root,COG1960@2|Bacteria,2GKK9@201174|Actinobacteria,4EUWH@85013|Frankiales	201174|Actinobacteria	C	Acyl-CoA dehydrogenase, middle domain	fadE10	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N,DUF1974
HKD2_k127_8984639_3	1894.JOER01000025_gene6954	1.923e-06	54.0	COG1366@1|root,COG1366@2|Bacteria	2|Bacteria	T	antisigma factor binding	-	-	2.4.1.187	ko:K04749,ko:K05946,ko:K06378	ko05111,map05111	-	-	-	ko00000,ko00001,ko01000,ko01003,ko03021	-	GT26	-	Glyco_tran_WecB,STAS,STAS_2
HKD2_k127_8984639_2	298654.FraEuI1c_0952	1.703e-61	218.0	COG1250@1|root,COG1250@2|Bacteria,2GJBM@201174|Actinobacteria,4ERI1@85013|Frankiales	201174|Actinobacteria	I	3-hydroxyacyl-CoA dehydrogenase	-	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
HKD2_k127_8988179_0	710111.FraQA3DRAFT_3341	1.272e-174	559.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HKD2_k127_8988179_4	525909.Afer_0292	9.71e-21	108.0	COG0589@1|root,COG0589@2|Bacteria,2GMFE@201174|Actinobacteria,4CNXA@84992|Acidimicrobiia	84992|Acidimicrobiia	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD2_k127_8988179_2	298655.KI912266_gene2847	4.797e-28	120.0	COG0517@1|root,COG0517@2|Bacteria,2H0MS@201174|Actinobacteria	201174|Actinobacteria	T	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
HKD2_k127_8988179_1	1298864.AUEQ01000010_gene3347	3.181e-71	245.0	COG1839@1|root,COG1839@2|Bacteria,2IAR3@201174|Actinobacteria,237WT@1762|Mycobacteriaceae	201174|Actinobacteria	S	Adenosine specific kinase	-	-	-	ko:K09129	-	-	-	-	ko00000	-	-	-	Adenosine_kin
HKD2_k127_8988179_8	656024.FsymDg_2714	6.601e-08	63.0	2B44D@1|root,31WUW@2|Bacteria,2GXYK@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8988179_5	1380354.JIAN01000009_gene3720	2.801e-19	98.0	COG1113@1|root,COG1113@2|Bacteria,2GRKY@201174|Actinobacteria	201174|Actinobacteria	E	amino acid transport	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8988179_3	1267535.KB906767_gene1595	6.752e-22	105.0	COG3619@1|root,COG3619@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF1275)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1275
HKD2_k127_8988179_7	35754.JNYJ01000072_gene2527	3.51e-08	61.0	COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,2GKI9@201174|Actinobacteria,4D913@85008|Micromonosporales	201174|Actinobacteria	C	FAD linked oxidases, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG,FAD-oxidase_C,FAD_binding_4,Fer4_8
HKD2_k127_8988179_6	656024.FsymDg_1644	7.435e-14	82.0	COG0568@1|root,COG0568@2|Bacteria,2GK3Z@201174|Actinobacteria,4ERX9@85013|Frankiales	201174|Actinobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	sigA	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
HKD2_k127_8996246_3	365528.KB891241_gene6241	4e-185	586.0	COG0123@1|root,COG0123@2|Bacteria,2GJUH@201174|Actinobacteria,4ES09@85013|Frankiales	201174|Actinobacteria	BQ	PFAM Histone deacetylase	acuC	-	-	ko:K04768	-	-	-	-	ko00000	-	-	-	Hist_deacetyl
HKD2_k127_8996246_1	1463825.JNXC01000002_gene4483	1.082e-243	785.0	COG0454@1|root,COG1042@1|root,COG0456@2|Bacteria,COG1042@2|Bacteria,2GKN1@201174|Actinobacteria,4DYY0@85010|Pseudonocardiales	201174|Actinobacteria	CK	Acyl-CoA synthetase (NDP forming)	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig
HKD2_k127_8996246_9	656024.FsymDg_1434	2.665e-108	357.0	2CEY7@1|root,2Z8CG@2|Bacteria,2GKI0@201174|Actinobacteria,4ES2J@85013|Frankiales	201174|Actinobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8996246_0	298654.FraEuI1c_5794	0.0	1014.0	COG1053@1|root,COG1053@2|Bacteria,2GJ45@201174|Actinobacteria,4ES69@85013|Frankiales	201174|Actinobacteria	C	PFAM fumarate reductase succinate dehydrogenase flavoprotein	sdhA	GO:0000104,GO:0000166,GO:0001539,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006091,GO:0006113,GO:0006928,GO:0006950,GO:0006974,GO:0006996,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016043,GO:0016491,GO:0016627,GO:0022607,GO:0022900,GO:0030030,GO:0030031,GO:0032991,GO:0033554,GO:0036094,GO:0040011,GO:0043167,GO:0043168,GO:0044085,GO:0044237,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0044780,GO:0044781,GO:0045273,GO:0045274,GO:0045283,GO:0045284,GO:0045333,GO:0048037,GO:0048870,GO:0050660,GO:0050662,GO:0050896,GO:0051179,GO:0051674,GO:0051716,GO:0055114,GO:0070469,GO:0070470,GO:0070925,GO:0071840,GO:0071944,GO:0071949,GO:0071973,GO:0097159,GO:0097588,GO:0098796,GO:0098797,GO:0098803,GO:1901265,GO:1901363	1.3.5.1,1.3.5.4,1.4.3.16	ko:K00239,ko:K00278	ko00020,ko00190,ko00250,ko00650,ko00720,ko00760,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00250,map00650,map00720,map00760,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00115,M00149,M00173,M00374,M00376	R00357,R00481,R02164	RC00006,RC00045,RC02566	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
HKD2_k127_8996246_5	656024.FsymDg_1432	8.851e-127	437.0	COG0479@1|root,COG0479@2|Bacteria,2GP9C@201174|Actinobacteria,4ERFH@85013|Frankiales	201174|Actinobacteria	C	Succinate dehydrogenase and fumarate reductase iron-sulfur protein	sdhB1	-	1.3.5.1,1.3.5.4	ko:K00240	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv0247c	Fer2_3,Fer4_8
HKD2_k127_8996246_7	656024.FsymDg_3593	7.836e-114	373.0	COG1119@1|root,COG1119@2|Bacteria,2GIXX@201174|Actinobacteria,4ESB7@85013|Frankiales	201174|Actinobacteria	P	PFAM ABC transporter	ylmA	-	3.6.3.34	ko:K02013	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14	-	-	ABC_tran
HKD2_k127_8996246_12	1089545.KB913037_gene6910	2.126e-27	120.0	COG1051@1|root,COG1051@2|Bacteria,2I2YK@201174|Actinobacteria,4E65Q@85010|Pseudonocardiales	201174|Actinobacteria	F	belongs to the nudix hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
HKD2_k127_8996246_11	298653.Franean1_6461	3.569e-39	153.0	COG4911@1|root,COG4911@2|Bacteria,2IMEK@201174|Actinobacteria,4EWBF@85013|Frankiales	201174|Actinobacteria	S	Uncharacterized conserved protein (DUF2203)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2203
HKD2_k127_8996246_10	1283283.ATXA01000007_gene3875	1.248e-80	279.0	COG5006@1|root,COG5006@2|Bacteria,2GJKB@201174|Actinobacteria,4EV3B@85013|Frankiales	201174|Actinobacteria	S	EamA-like transporter family	-	-	-	ko:K11939	-	-	-	-	ko00000,ko02000	2.A.7.3.6	-	-	EamA
HKD2_k127_8996246_14	1121272.KB903252_gene1127	7.365e-21	108.0	2CA4F@1|root,33DCB@2|Bacteria,2GRQ2@201174|Actinobacteria,4DG72@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8996246_4	35754.JNYJ01000011_gene717	1.349e-130	439.0	COG0673@1|root,COG0673@2|Bacteria,2GN2Z@201174|Actinobacteria,4DA2M@85008|Micromonosporales	201174|Actinobacteria	S	Oxidoreductase family, C-terminal alpha/beta domain	ydgJ	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
HKD2_k127_8996246_8	1229780.BN381_310030	3.964e-109	360.0	COG1024@1|root,COG1024@2|Bacteria,2GJG7@201174|Actinobacteria	201174|Actinobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	echA21	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005777,GO:0042579,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464	4.2.1.17	ko:K01692	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
HKD2_k127_8996246_2	298655.KI912267_gene8010	1.765e-231	728.0	COG0006@1|root,COG0006@2|Bacteria,2GM7D@201174|Actinobacteria,4ERXV@85013|Frankiales	201174|Actinobacteria	E	PFAM peptidase M24	pepP	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	AMP_N,Peptidase_M24
HKD2_k127_8996246_15	298654.FraEuI1c_4861	4.053e-13	75.0	2BV4Z@1|root,32QI6@2|Bacteria,2HE3U@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8996246_13	106370.Francci3_2335	1.482e-24	116.0	COG2337@1|root,COG2337@2|Bacteria,2HKW6@201174|Actinobacteria,4EWMI@85013|Frankiales	201174|Actinobacteria	L	Toxic component of a toxin-antitoxin (TA) module	-	-	-	ko:K07171	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PemK_toxin
HKD2_k127_8996246_6	656024.FsymDg_3587	2.386e-114	376.0	COG1295@1|root,COG1295@2|Bacteria,2GM6P@201174|Actinobacteria,4ESUQ@85013|Frankiales	201174|Actinobacteria	S	Virulence factor BrkB	-	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Virul_fac_BrkB
HKD2_k127_9033359_5	446462.Amir_1997	1.911e-57	207.0	COG0380@1|root,COG0380@2|Bacteria,2GPYE@201174|Actinobacteria,4E97F@85010|Pseudonocardiales	201174|Actinobacteria	G	Glycosyltransferase family 20	-	-	2.5.1.135	ko:K20436	ko00525,ko01130,map00525,map01130	M00815	R11239,R11250,R11497	RC03400,RC03401	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyco_transf_20
HKD2_k127_9033359_1	1123320.KB889596_gene8791	3.872e-153	506.0	COG0160@1|root,COG0160@2|Bacteria,2I2F3@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.19	ko:K00823,ko:K20435	ko00250,ko00410,ko00525,ko00640,ko00650,ko01100,ko01120,ko01130,map00250,map00410,map00525,map00640,map00650,map01100,map01120,map01130	M00027,M00815	R00908,R01648,R11238	RC00006,RC00062,RC01514	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
HKD2_k127_9033359_4	211114.JOEF01000006_gene2532	6.765e-59	218.0	COG1063@1|root,COG1063@2|Bacteria,2IDWA@201174|Actinobacteria,4E4XZ@85010|Pseudonocardiales	201174|Actinobacteria	E	Alcohol dehydrogenase, GroES domain protein	-	-	-	ko:K20434	ko00525,ko01130,map00525,map01130	M00815	R11236	RC03399	ko00000,ko00001,ko00002	-	-	-	ADH_N
HKD2_k127_9033359_7	378806.STAUR_3133	2.227e-53	213.0	COG2971@1|root,COG2971@2|Bacteria	2|Bacteria	G	N-acetylglucosamine kinase activity	gspK	GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0044237,GO:0047931	2.7.1.8	ko:K18676	ko00520,ko01100,map00520,map01100	-	R01961	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	BcrAD_BadFG
HKD2_k127_9033359_3	67352.JODS01000017_gene2960	1.042e-73	262.0	COG0738@1|root,COG0738@2|Bacteria,2I8UP@201174|Actinobacteria	201174|Actinobacteria	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD2_k127_9033359_0	298653.Franean1_6445	3.959e-167	545.0	COG0723@1|root,COG0723@2|Bacteria,2I2RI@201174|Actinobacteria,4EUMX@85013|Frankiales	201174|Actinobacteria	C	plastoquinol--plastocyanin reductase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9033359_11	253839.SSNG_07092	1.017e-34	141.0	2B5TZ@1|root,31YPR@2|Bacteria,2H12E@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9033359_9	208444.JNYY01000001_gene5051	4.782e-39	159.0	COG0607@1|root,COG0607@2|Bacteria,2IN5N@201174|Actinobacteria,4EBXS@85010|Pseudonocardiales	201174|Actinobacteria	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
HKD2_k127_9033359_6	526225.Gobs_1788	3.629e-56	202.0	COG1182@1|root,COG1182@2|Bacteria,2I9P0@201174|Actinobacteria,4ESPU@85013|Frankiales	201174|Actinobacteria	C	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity	azoR	-	-	ko:K01118	-	-	-	-	ko00000,ko01000	-	-	-	Flavodoxin_2
HKD2_k127_9033359_12	287986.DV20_29870	7.809e-32	136.0	COG1182@1|root,COG1182@2|Bacteria,2I9P0@201174|Actinobacteria,4E6FT@85010|Pseudonocardiales	201174|Actinobacteria	I	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity	azoR	-	-	ko:K01118	-	-	-	-	ko00000,ko01000	-	-	-	Flavodoxin_2
HKD2_k127_9033359_2	287986.DV20_29875	3.349e-77	266.0	COG1309@1|root,COG1309@2|Bacteria,2GRIJ@201174|Actinobacteria,4E5A6@85010|Pseudonocardiales	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
HKD2_k127_9033359_10	656024.FsymDg_2642	9.251e-36	136.0	COG4118@1|root,COG4118@2|Bacteria,2HRVY@201174|Actinobacteria,4EWXG@85013|Frankiales	201174|Actinobacteria	D	Antitoxin component of a toxin-antitoxin (TA) module	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
HKD2_k127_9033359_8	656024.FsymDg_2643	2.556e-50	184.0	COG3744@1|root,COG3744@2|Bacteria,2HRGI@201174|Actinobacteria,4EWN7@85013|Frankiales	201174|Actinobacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
HKD2_k127_90508_16	469371.Tbis_2158	4.439e-32	126.0	COG1131@1|root,COG1131@2|Bacteria,2GKI7@201174|Actinobacteria,4DYMU@85010|Pseudonocardiales	201174|Actinobacteria	V	TIGRFAM daunorubicin resistance ABC transporter ATP-binding subunit	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
HKD2_k127_90508_19	675635.Psed_2614	9.311e-16	87.0	COG1846@1|root,COG1846@2|Bacteria,2IMJ9@201174|Actinobacteria,4E5VZ@85010|Pseudonocardiales	201174|Actinobacteria	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
HKD2_k127_90508_12	1380393.JHVP01000001_gene2657	8.474e-67	241.0	COG0744@1|root,COG0744@2|Bacteria,2GK21@201174|Actinobacteria,4ERGQ@85013|Frankiales	201174|Actinobacteria	M	PFAM glycosyl transferase, family 51	-	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	PASTA,Transgly,Transpeptidase
HKD2_k127_90508_14	656024.FsymDg_0596	5.315e-45	168.0	COG1848@1|root,COG1848@2|Bacteria,2GUVQ@201174|Actinobacteria	201174|Actinobacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_90508_6	298655.KI912266_gene702	1.498e-118	395.0	COG0500@1|root,COG2226@2|Bacteria,2GM2N@201174|Actinobacteria,4EVM3@85013|Frankiales	201174|Actinobacteria	Q	Pfam:Methyltransf_26	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
HKD2_k127_90508_10	298654.FraEuI1c_1576	1.294e-73	255.0	COG1733@1|root,COG1733@2|Bacteria,2I9HE@201174|Actinobacteria,4ET4Y@85013|Frankiales	201174|Actinobacteria	K	HxlR-like helix-turn-helix	-	-	-	-	-	-	-	-	-	-	-	-	HxlR
HKD2_k127_90508_13	1068980.ARVW01000001_gene6790	1.349e-66	239.0	COG0693@1|root,COG0693@2|Bacteria,2H6FV@201174|Actinobacteria	201174|Actinobacteria	S	ThiJ PfpI	-	-	-	-	-	-	-	-	-	-	-	-	DJ-1_PfpI
HKD2_k127_90508_9	1120950.KB892812_gene7005	1.051e-73	258.0	COG0388@1|root,COG0388@2|Bacteria,2GMQA@201174|Actinobacteria,4DNQW@85009|Propionibacteriales	201174|Actinobacteria	S	Carbon-nitrogen hydrolase	-	-	-	ko:K11206	-	-	-	-	ko00000,ko01000	-	-	-	CN_hydrolase
HKD2_k127_90508_11	1449347.JQLN01000007_gene1478	2.134e-70	246.0	COG1853@1|root,COG1853@2|Bacteria,2I8YR@201174|Actinobacteria,2M3ER@2063|Kitasatospora	201174|Actinobacteria	S	Flavin reductase like domain	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
HKD2_k127_90508_2	1449347.JQLN01000007_gene1477	1.114e-191	603.0	COG2141@1|root,COG2141@2|Bacteria,2GITK@201174|Actinobacteria,2M59R@2063|Kitasatospora	201174|Actinobacteria	C	Luciferase-like monooxygenase	limB	-	1.14.13.107	ko:K14733	ko00903,map00903	-	R06398,R09385,R09389,R09393	RC01506	ko00000,ko00001,ko01000	-	-	-	Bac_luciferase
HKD2_k127_90508_3	414996.IL38_10690	2.398e-171	570.0	COG0151@1|root,COG0151@2|Bacteria,2GR5Q@201174|Actinobacteria	201174|Actinobacteria	F	ATP-grasp domain	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_4
HKD2_k127_90508_1	414996.IL38_10695	2.849e-211	671.0	COG1167@1|root,COG1167@2|Bacteria,2GITW@201174|Actinobacteria,408JD@622450|Actinopolysporales	201174|Actinobacteria	EK	Alanine-glyoxylate amino-transferase	-	-	2.6.1.103	ko:K16423	ko00261,ko01055,ko01130,map00261,map01055,map01130	-	R06626,R06634	RC00006,RC01104	ko00000,ko00001,ko01000	-	-	-	Aminotran_1_2
HKD2_k127_90508_17	1449347.JQLN01000007_gene1474	5.106e-31	132.0	COG2350@1|root,COG2350@2|Bacteria	2|Bacteria	S	YCII-related domain	-	-	-	ko:K09780	-	-	-	-	ko00000	-	-	-	YCII
HKD2_k127_90508_7	1449976.KALB_1759	5.08e-115	381.0	COG0300@1|root,COG0300@2|Bacteria	2|Bacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	1.1.1.100,1.1.1.401	ko:K00059,ko:K07124,ko:K21883	ko00051,ko00061,ko00333,ko00780,ko01040,ko01100,ko01120,ko01130,ko01212,map00051,map00061,map00333,map00780,map01040,map01100,map01120,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11339,R11671	RC00029,RC00089,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short
HKD2_k127_90508_4	1449976.KALB_1760	7.918e-138	450.0	COG4948@1|root,COG4948@2|Bacteria	2|Bacteria	M	carboxylic acid catabolic process	-	-	5.1.1.20,5.5.1.1	ko:K01856,ko:K19802	ko00361,ko00362,ko00364,ko00623,ko01100,ko01120,ko01220,map00361,map00362,map00364,map00623,map01100,map01120,map01220	M00568	R05300,R05390,R06989,R08116,R09229,R10938	RC00903,RC01038,RC01108,RC01321,RC01356,RC03309	ko00000,ko00001,ko00002,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
HKD2_k127_90508_8	1449976.KALB_1761	1.346e-111	368.0	COG2267@1|root,COG2267@2|Bacteria,2IE5T@201174|Actinobacteria	201174|Actinobacteria	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4
HKD2_k127_90508_0	1449976.KALB_1762	4.169e-283	890.0	COG3568@1|root,COG3568@2|Bacteria,2IEQF@201174|Actinobacteria	201174|Actinobacteria	S	GH3 auxin-responsive promoter	-	-	-	-	-	-	-	-	-	-	-	-	GH3
HKD2_k127_90508_5	1449976.KALB_1764	2.089e-135	441.0	COG0477@1|root,COG2814@2|Bacteria,2IFP3@201174|Actinobacteria,4EEQE@85010|Pseudonocardiales	201174|Actinobacteria	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD2_k127_90508_21	1122138.AQUZ01000101_gene8429	0.0003061	48.0	COG0477@1|root,COG2814@2|Bacteria,2ID9K@201174|Actinobacteria	201174|Actinobacteria	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD2_k127_90508_20	543632.JOJL01000120_gene273	1.234e-10	66.0	COG5433@1|root,COG5433@2|Bacteria,2HYBN@201174|Actinobacteria,4DI86@85008|Micromonosporales	201174|Actinobacteria	L	required for the transposition of insertion element IS2404	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_assoc
HKD2_k127_90508_15	547045.NEISICOT_03138	1.132e-32	138.0	COG3338@1|root,COG3338@2|Bacteria,1PEA6@1224|Proteobacteria,2VI5K@28216|Betaproteobacteria,2KRCV@206351|Neisseriales	206351|Neisseriales	P	Eukaryotic-type carbonic anhydrase	-	-	4.2.1.1	ko:K01674	ko00910,map00910	-	R00132,R10092	RC02807	ko00000,ko00001,ko01000	-	-	-	Carb_anhydrase
HKD2_k127_9066734_2	1123024.AUII01000002_gene1082	8.289e-31	123.0	COG1848@1|root,COG1848@2|Bacteria,2H6JZ@201174|Actinobacteria	201174|Actinobacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
HKD2_k127_9066734_1	656024.FsymDg_3806	3.793e-143	467.0	COG0503@1|root,COG0503@2|Bacteria,2I3NY@201174|Actinobacteria,4EV66@85013|Frankiales	201174|Actinobacteria	F	Phosphoribosyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	PRTase_2,TRSP
HKD2_k127_9066734_0	298653.Franean1_1062	4.763e-178	564.0	COG2301@1|root,COG2301@2|Bacteria,2GK4H@201174|Actinobacteria,4ETR2@85013|Frankiales	201174|Actinobacteria	G	C-C_Bond_Lyase of the TIM-Barrel fold	-	-	-	-	-	-	-	-	-	-	-	-	C-C_Bond_Lyase
HKD2_k127_9108666_4	1172186.KB911471_gene2821	1.584e-21	102.0	2DPNA@1|root,332RJ@2|Bacteria,2I2PY@201174|Actinobacteria,239ME@1762|Mycobacteriaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4190
HKD2_k127_9108666_2	561175.KB894093_gene3250	1.604e-48	194.0	COG3266@1|root,COG3266@2|Bacteria,2I39E@201174|Actinobacteria,4EHMF@85012|Streptosporangiales	201174|Actinobacteria	S	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9108666_1	326424.FRAAL1157	9.681e-158	500.0	COG0074@1|root,COG0074@2|Bacteria,2GK00@201174|Actinobacteria,4ERDM@85013|Frankiales	201174|Actinobacteria	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit	sucD	-	6.2.1.5	ko:K01902	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_binding,Ligase_CoA
HKD2_k127_9108666_0	656024.FsymDg_3894	3.136e-190	610.0	COG0045@1|root,COG0045@2|Bacteria,2GKSB@201174|Actinobacteria,4ES6Z@85013|Frankiales	201174|Actinobacteria	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit	sucC	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	6.2.1.5	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,Ligase_CoA
HKD2_k127_9108666_3	357808.RoseRS_2323	1.099e-33	146.0	COG3209@1|root,COG3209@2|Bacteria,2G6KZ@200795|Chloroflexi,376AQ@32061|Chloroflexia	32061|Chloroflexia	M	Belongs to the glycosyl hydrolase 5 (cellulase A) family	-	-	-	-	-	-	-	-	-	-	-	-	RHS_repeat
HKD2_k127_9142549_2	1385521.N803_10960	9.618e-17	87.0	COG1848@1|root,COG1848@2|Bacteria,2IR37@201174|Actinobacteria	201174|Actinobacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	GO:0005575,GO:0005576	-	-	-	-	-	-	-	-	-	-	PIN
HKD2_k127_9142549_3	419947.MRA_2623A	4.758e-09	67.0	COG2002@1|root,COG2002@2|Bacteria,2HANT@201174|Actinobacteria	201174|Actinobacteria	K	toxin-antitoxin pair type II binding	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9142549_1	298653.Franean1_6389	3.373e-120	391.0	COG2141@1|root,COG2141@2|Bacteria,2HGTQ@201174|Actinobacteria,4ET1X@85013|Frankiales	201174|Actinobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
HKD2_k127_9142549_0	298653.Franean1_1098	9.91e-179	584.0	COG0473@1|root,COG0473@2|Bacteria,2GK44@201174|Actinobacteria,4ERJS@85013|Frankiales	201174|Actinobacteria	C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate	leuB	GO:0003674,GO:0003824,GO:0003862,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016616,GO:0040007,GO:0044424,GO:0044464,GO:0055114	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
HKD2_k127_9142549_4	526225.Gobs_0888	1.723e-05	55.0	COG3861@1|root,COG3861@2|Bacteria	2|Bacteria	S	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity	puhA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009579,GO:0016020,GO:0034357,GO:0042716,GO:0042717,GO:0044424,GO:0044436,GO:0044444,GO:0044464	-	ko:K13991	ko02020,map02020	-	-	-	ko00000,ko00001,ko00194	-	-	-	PRC,PRCH
HKD2_k127_9150646_6	1068980.ARVW01000001_gene4253	8.364e-33	140.0	COG2064@1|root,COG2064@2|Bacteria,2HZTC@201174|Actinobacteria	201174|Actinobacteria	NU	type II secretion system protein	-	-	-	-	-	-	-	-	-	-	-	-	T2SSF
HKD2_k127_9150646_7	68570.DC74_7939	7.009e-22	98.0	COG2020@1|root,COG2020@2|Bacteria	2|Bacteria	O	methyltransferase activity	-	-	2.1.1.100	ko:K00587	ko00900,ko01130,map00900,map01130	-	R04496	RC00003,RC00460	ko00000,ko00001,ko01000	-	-	-	ICMT,PEMT
HKD2_k127_9150646_3	234267.Acid_7933	1.519e-72	270.0	COG0175@1|root,COG0529@1|root,COG0175@2|Bacteria,COG0529@2|Bacteria,3Y5BG@57723|Acidobacteria	57723|Acidobacteria	F	Catalyzes the synthesis of activated sulfate	cysC	-	1.8.4.10,1.8.4.8,2.7.1.25	ko:K00390,ko:K00860	ko00230,ko00920,ko01100,ko01120,map00230,map00920,map01100,map01120	M00176	R00509,R02021,R04928	RC00002,RC00007,RC00078,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	-	APS_kinase
HKD2_k127_9150646_0	292459.STH1143	8.35e-127	425.0	COG2046@1|root,COG2046@2|Bacteria,1TR4C@1239|Firmicutes,249ZJ@186801|Clostridia	186801|Clostridia	H	Belongs to the sulfate adenylyltransferase family	sat	-	2.7.7.4	ko:K00958	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00529,R04929	RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-sulfurylase,PUA_2
HKD2_k127_9150646_4	118173.KB235914_gene218	1.324e-61	218.0	COG0529@1|root,COG0529@2|Bacteria,1G21C@1117|Cyanobacteria,1H93G@1150|Oscillatoriales	1117|Cyanobacteria	F	Catalyzes the synthesis of activated sulfate	cysC	-	2.7.1.25	ko:K00860	ko00230,ko00920,ko01100,ko01120,map00230,map00920,map01100,map01120	M00176	R00509,R04928	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	APS_kinase
HKD2_k127_9150646_2	656024.FsymDg_3649	1.484e-88	301.0	COG0600@1|root,COG0600@2|Bacteria,2GIWG@201174|Actinobacteria,4EUUR@85013|Frankiales	201174|Actinobacteria	P	PFAM binding-protein-dependent transport systems inner membrane component	ssuC3	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
HKD2_k127_9150646_1	649831.L083_7272	2.903e-96	321.0	COG1116@1|root,COG1116@2|Bacteria,2GN33@201174|Actinobacteria,4DBHB@85008|Micromonosporales	201174|Actinobacteria	P	ATPases associated with a variety of cellular activities	ssuB	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
HKD2_k127_9150646_5	479432.Sros_9276	1.982e-60	214.0	COG0715@1|root,COG0715@2|Bacteria,2GK7X@201174|Actinobacteria,4EI7Q@85012|Streptosporangiales	201174|Actinobacteria	P	NMT1-like family	ssuA3	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1_2
HKD2_k127_9170860_2	326424.FRAAL2187	1.904e-71	243.0	COG2001@1|root,COG2001@2|Bacteria,2IHUB@201174|Actinobacteria,4ESJN@85013|Frankiales	201174|Actinobacteria	K	Belongs to the MraZ family	mraZ	GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031333,GO:0040007,GO:0043254,GO:0043565,GO:0044087,GO:0044212,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2000142,GO:2000143,GO:2001141	-	ko:K03925	-	-	-	-	ko00000	-	-	-	MraZ
HKD2_k127_9170860_0	656024.FsymDg_3119	7.489e-129	427.0	COG0275@1|root,COG0275@2|Bacteria,2GJGK@201174|Actinobacteria,4ERYS@85013|Frankiales	201174|Actinobacteria	J	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA	rsmH	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.199	ko:K03438	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltransf_5
HKD2_k127_9170860_3	656024.FsymDg_3118	2.594e-20	106.0	COG2919@1|root,COG2919@2|Bacteria,2H1HW@201174|Actinobacteria,4ETGR@85013|Frankiales	201174|Actinobacteria	D	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9170860_1	656024.FsymDg_3117	5.264e-109	372.0	COG0768@1|root,COG0768@2|Bacteria,2GKHH@201174|Actinobacteria,4ERN7@85013|Frankiales	201174|Actinobacteria	M	Penicillin-binding protein, dimerisation domain	ftsI	-	3.4.16.4	ko:K03587	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011,ko03036	-	-	-	PBP_dimer,Transpeptidase
HKD2_k127_9185398_9	1123065.ATWL01000015_gene2591	6.781e-29	120.0	COG3276@1|root,COG3276@2|Bacteria,2GKF9@201174|Actinobacteria	201174|Actinobacteria	J	Translation elongation factor	selB	-	-	ko:K03833	-	-	-	-	ko00000,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,SelB-wing_2,SelB-wing_3
HKD2_k127_9185398_4	222534.KB893718_gene2243	3.49e-142	471.0	COG0477@1|root,COG0477@2|Bacteria,2GK06@201174|Actinobacteria,4EXBW@85013|Frankiales	201174|Actinobacteria	EGP	Major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
HKD2_k127_9185398_10	1123024.AUII01000024_gene242	9.793e-26	112.0	COG1846@1|root,COG1846@2|Bacteria,2IH3H@201174|Actinobacteria,4E4SB@85010|Pseudonocardiales	201174|Actinobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
HKD2_k127_9185398_7	1206101.AZXC01000008_gene3036	2.81e-52	192.0	COG1309@1|root,COG1309@2|Bacteria,2IP3P@201174|Actinobacteria	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
HKD2_k127_9185398_5	1122611.KB903963_gene4645	8.477e-56	216.0	COG0697@1|root,COG0697@2|Bacteria,2GM50@201174|Actinobacteria,4EQYN@85012|Streptosporangiales	201174|Actinobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HKD2_k127_9185398_6	2002.JOEQ01000012_gene5605	3.748e-54	209.0	COG1396@1|root,COG1917@1|root,COG1396@2|Bacteria,COG1917@2|Bacteria,2GXAS@201174|Actinobacteria,4ER2B@85012|Streptosporangiales	201174|Actinobacteria	K	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2,HTH_3,HTH_31
HKD2_k127_9185398_3	263358.VAB18032_13940	3.276e-148	530.0	COG0297@1|root,COG0297@2|Bacteria,2I2EE@201174|Actinobacteria,4DBH0@85008|Micromonosporales	201174|Actinobacteria	G	Glycosyl transferases group 1	glgA	GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006073,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0071704,GO:1901576	2.4.1.342	ko:K16148	ko00500,ko01100,map00500,map01100	-	R02421,R11530	RC00005,RC00049,RC02748	ko00000,ko00001,ko01000,ko01003	-	GT4	-	Glyco_transf_4,Glycos_transf_1
HKD2_k127_9185398_1	656024.FsymDg_0479	1.457e-189	622.0	COG0448@1|root,COG0448@2|Bacteria,2I2EF@201174|Actinobacteria,4ERNH@85013|Frankiales	201174|Actinobacteria	H	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans	glgC	-	2.7.7.27	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	M00565	R00948	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
HKD2_k127_9185398_8	1172181.KB911739_gene6580	3.862e-41	176.0	COG2114@1|root,COG3899@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,2GJRI@201174|Actinobacteria	201174|Actinobacteria	T	Adenylyl cyclase class-3 4 guanylyl cyclase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,DZR,Guanylate_cyc
HKD2_k127_9185398_0	106370.Francci3_2830	6.856e-252	781.0	COG2873@1|root,COG2873@2|Bacteria,2I2EB@201174|Actinobacteria,4ES02@85013|Frankiales	201174|Actinobacteria	E	PFAM Cys Met metabolism	metY	-	2.5.1.49	ko:K01740	ko00270,ko01100,map00270,map01100	-	R01287,R04859	RC00020,RC02821,RC02848	ko00000,ko00001,ko01000	-	-	iNJ661.Rv3340	Cys_Met_Meta_PP
HKD2_k127_9185398_2	365528.KB891104_gene3779	9.045e-180	572.0	COG2021@1|root,COG2021@2|Bacteria,2GKNJ@201174|Actinobacteria,4ERSW@85013|Frankiales	201174|Actinobacteria	E	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine	metXA	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004414,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008374,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009092,GO:0009987,GO:0016020,GO:0016053,GO:0016407,GO:0016413,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.3.1.31	ko:K00641	ko00270,ko01100,ko01130,map00270,map01100,map01130	-	R01776	RC00004,RC00041	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1
HKD2_k127_9189418_1	326424.FRAAL0126	8.207e-214	698.0	COG3225@1|root,COG3225@2|Bacteria,2GMTX@201174|Actinobacteria,4ESFT@85013|Frankiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9189418_6	656024.FsymDg_0155	3.761e-114	375.0	28NWB@1|root,2ZBU7@2|Bacteria,2GJ74@201174|Actinobacteria,4ESJV@85013|Frankiales	201174|Actinobacteria	S	Protein of unknown function (DUF3027)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3027
HKD2_k127_9189418_10	656024.FsymDg_0156	2.753e-15	89.0	COG0477@1|root,COG2814@2|Bacteria,2GKRT@201174|Actinobacteria,4ERU5@85013|Frankiales	201174|Actinobacteria	EGP	Major facilitator superfamily	-	GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD2_k127_9189418_3	326424.FRAAL6732	2.38e-137	446.0	COG0477@1|root,COG2814@2|Bacteria,2GKRT@201174|Actinobacteria,4ERU5@85013|Frankiales	201174|Actinobacteria	EGP	Major facilitator superfamily	-	GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD2_k127_9189418_8	1122919.KB905609_gene4493	5.243e-48	184.0	COG0775@1|root,COG0775@2|Bacteria,1TR6C@1239|Firmicutes,4HGPF@91061|Bacilli,26WSK@186822|Paenibacillaceae	91061|Bacilli	F	Catalyzes the hydrolysis of futalosine (FL) to dehypoxanthine futalosine (DHFL) and hypoxanthine, a step in the biosynthesis of menaquinone (MK, vitamin K2)	mqnB	-	3.2.2.26	ko:K11783	ko00130,ko01110,map00130,map01110	-	R08587	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	PNP_UDP_1
HKD2_k127_9189418_4	656024.FsymDg_0159	4.622e-122	411.0	COG2107@1|root,COG2107@2|Bacteria,2GJHY@201174|Actinobacteria,4EUYC@85013|Frankiales	201174|Actinobacteria	S	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)	mqnD	-	-	ko:K11785	ko00130,ko01110,map00130,map01110	-	R08589	RC02330	ko00000,ko00001,ko01000	-	-	-	VitK2_biosynth
HKD2_k127_9189418_7	106370.Francci3_4426	1.98e-64	222.0	COG1278@1|root,COG1278@2|Bacteria,2IKXN@201174|Actinobacteria,4ESU8@85013|Frankiales	201174|Actinobacteria	K	PFAM Cold-shock protein, DNA-binding	cspB	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
HKD2_k127_9189418_5	365528.KB891209_gene2204	1.258e-116	381.0	COG0546@1|root,COG1606@1|root,COG0546@2|Bacteria,COG1606@2|Bacteria,2GPA1@201174|Actinobacteria,4EUBD@85013|Frankiales	201174|Actinobacteria	S	PFAM ExsB family protein	-	-	-	ko:K06864	-	-	-	-	ko00000	-	-	-	Asn_synthase,HAD,HAD_2,Hydrolase_like,NAD_synthase,QueC
HKD2_k127_9189418_9	479435.Kfla_5347	1.9e-30	127.0	COG4636@1|root,COG4636@2|Bacteria,2IQKE@201174|Actinobacteria	201174|Actinobacteria	S	Putative restriction endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	Uma2
HKD2_k127_9189418_0	211114.JOEF01000040_gene5958	8.8e-265	838.0	COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria,4DZ47@85010|Pseudonocardiales	201174|Actinobacteria	IQ	Acyl-CoA synthetase (AMP-forming) AMP-acid ligase II	fadD35	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0042579,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464,GO:0051087	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
HKD2_k127_9189418_11	680198.SCAB_63691	3.487e-07	63.0	2B1K4@1|root,31U1J@2|Bacteria,2I8GP@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF3068)	porA	-	-	-	-	-	-	-	-	-	-	-	DUF3068
HKD2_k127_9189418_2	656024.FsymDg_4447	1.456e-155	497.0	COG1061@1|root,COG1061@2|Bacteria,2GIR9@201174|Actinobacteria,4ES5M@85013|Frankiales	201174|Actinobacteria	L	type III restriction protein res subunit	ercc3	-	3.6.4.12	ko:K10843	ko03022,ko03420,map03022,map03420	M00290	-	-	ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	ERCC3_RAD25_C,Helicase_C_3,ResIII
HKD2_k127_9200628_3	106370.Francci3_0762	1.215e-59	226.0	COG5180@1|root,COG5180@2|Bacteria,2GKJ7@201174|Actinobacteria	201174|Actinobacteria	A	pathogenesis	-	-	-	-	-	-	-	-	-	-	-	-	GPDPase_memb
HKD2_k127_9200628_1	269800.Tfu_2496	9.646e-112	370.0	COG0745@1|root,COG0745@2|Bacteria,2GJE6@201174|Actinobacteria,4EFYW@85012|Streptosporangiales	201174|Actinobacteria	T	Transcriptional regulatory protein, C terminal	mtrA	GO:0005575,GO:0005623,GO:0005886,GO:0006355,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016020,GO:0016310,GO:0019219,GO:0019222,GO:0019538,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0044110,GO:0044116,GO:0044117,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044403,GO:0044419,GO:0044464,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051704,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:1901564,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141	-	ko:K07670	ko02020,map02020	M00461	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
HKD2_k127_9200628_0	1116232.AHBF01000076_gene8336	2.33e-144	476.0	COG5002@1|root,COG5002@2|Bacteria,2GJ2D@201174|Actinobacteria	201174|Actinobacteria	T	Histidine kinase	mtrB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464	2.7.13.3	ko:K07636,ko:K07654	ko02020,map02020	M00434,M00461	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
HKD2_k127_9200628_5	500153.JOEK01000002_gene599	8.644e-38	165.0	COG0823@1|root,COG0823@2|Bacteria,2I308@201174|Actinobacteria	201174|Actinobacteria	U	Lipoprotein LpqB beta-propeller domain	lpqB	-	-	-	-	-	-	-	-	-	-	-	Germane,Gmad1
HKD2_k127_9200628_4	710111.FraQA3DRAFT_3657	4.599e-44	174.0	COG1040@1|root,COG1040@2|Bacteria,2I9PA@201174|Actinobacteria,4ET02@85013|Frankiales	201174|Actinobacteria	S	phosphoribosyltransferase	pyrE_1	-	-	-	-	-	-	-	-	-	-	-	Pribosyltran
HKD2_k127_9200628_2	656024.FsymDg_1105	7.995e-68	239.0	COG1544@1|root,COG1544@2|Bacteria,2GMYF@201174|Actinobacteria,4ESQU@85013|Frankiales	201174|Actinobacteria	J	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase	hpf	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006417,GO:0006448,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015935,GO:0017148,GO:0019222,GO:0022626,GO:0022627,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0043021,GO:0043022,GO:0043024,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0045900,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:1990904,GO:2000112,GO:2000113	-	ko:K05808	-	-	-	-	ko00000,ko03009	-	-	-	Ribosom_S30AE_C,Ribosomal_S30AE
HKD2_k127_9200628_6	656024.FsymDg_1106	4.869e-29	119.0	COG2197@1|root,COG2197@2|Bacteria,2GKBX@201174|Actinobacteria,4ERMX@85013|Frankiales	201174|Actinobacteria	K	Response regulator receiver	-	-	-	ko:K02479	-	-	-	-	ko00000,ko02022	-	-	-	GerE,Response_reg
HKD2_k127_9205393_0	298653.Franean1_0190	2.83e-265	820.0	COG0542@1|root,COG0542@2|Bacteria,2GJ77@201174|Actinobacteria,4ERE5@85013|Frankiales	201174|Actinobacteria	O	Clp domain protein	clpC	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006457,GO:0008150,GO:0009987,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030312,GO:0040007,GO:0042802,GO:0042803,GO:0044183,GO:0044424,GO:0044444,GO:0044464,GO:0046983,GO:0071944	-	ko:K03696	ko01100,map01100	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N,UVR
HKD2_k127_9205393_7	1120934.KB894435_gene4441	3.309e-51	190.0	COG0350@1|root,COG0350@2|Bacteria,2GKA9@201174|Actinobacteria,4E3PH@85010|Pseudonocardiales	201174|Actinobacteria	L	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated	ogt	-	2.1.1.63	ko:K00567	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_binding_1,Methyltransf_1N
HKD2_k127_9205393_1	1123320.KB889685_gene2203	2.439e-199	646.0	COG0122@1|root,COG2169@1|root,COG0122@2|Bacteria,COG2169@2|Bacteria,2GITG@201174|Actinobacteria	201174|Actinobacteria	K	helix-turn-helix- domain containing protein, AraC type	ada	-	3.2.2.21	ko:K13529	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03000,ko03400	-	-	-	Ada_Zn_binding,AlkA_N,HTH_18,HhH-GPD
HKD2_k127_9205393_4	298655.KI912266_gene1553	1.269e-123	402.0	COG1194@1|root,COG1194@2|Bacteria,2GJD9@201174|Actinobacteria,4ES2G@85013|Frankiales	201174|Actinobacteria	L	helix-hairpin-helix motif	mutY	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016787,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:1901360	-	ko:K03575	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD
HKD2_k127_9205393_2	326424.FRAAL6529	1.963e-194	612.0	COG1623@1|root,COG1623@2|Bacteria,2GJ41@201174|Actinobacteria,4ERXA@85013|Frankiales	201174|Actinobacteria	L	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP	disA	-	2.7.7.85	ko:K07067	-	-	-	-	ko00000,ko01000	-	-	-	DisA-linker,DisA_N,HHH,HHH_2
HKD2_k127_9205393_3	365528.KB891220_gene1153	5.528e-190	607.0	COG1066@1|root,COG1066@2|Bacteria,2GMQ0@201174|Actinobacteria,4ERV3@85013|Frankiales	201174|Actinobacteria	O	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function	radA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K04485	-	-	-	-	ko00000,ko03400	-	-	-	AAA_25,ATPase,ChlI,Lon_C
HKD2_k127_9205393_8	222534.KB893724_gene429	3.799e-32	143.0	COG2847@1|root,COG2847@2|Bacteria,2ISZB@201174|Actinobacteria,4ETHN@85013|Frankiales	201174|Actinobacteria	S	Copper chaperone PCu(A)C	-	-	-	-	-	-	-	-	-	-	-	-	PCuAC
HKD2_k127_9205393_6	710111.FraQA3DRAFT_5267	7.251e-75	272.0	COG0382@1|root,COG0382@2|Bacteria,2GJT3@201174|Actinobacteria,4EVEN@85013|Frankiales	201174|Actinobacteria	H	PFAM UbiA prenyltransferase	ubiA	-	-	-	-	-	-	-	-	-	-	-	UbiA
HKD2_k127_9205393_5	1114959.SZMC14600_12555	2.45e-81	283.0	COG2227@1|root,COG2227@2|Bacteria,2ID71@201174|Actinobacteria,4E104@85010|Pseudonocardiales	201174|Actinobacteria	H	Hypothetical methyltransferase	ubiG	-	2.1.1.222,2.1.1.64	ko:K00568	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04988,R05614,R08769,R08781	RC00003,RC00392,RC01895	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_11
HKD2_k127_9227933_1	1064537.AGSO01000001_gene745	1.396e-53	195.0	COG1376@1|root,COG3409@1|root,COG1376@2|Bacteria,COG3409@2|Bacteria,2GXGF@201174|Actinobacteria,4FCDY@85020|Dermabacteraceae	201174|Actinobacteria	M	L,D-transpeptidase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_1,YkuD
HKD2_k127_9227933_0	649831.L083_2761	3.512e-224	702.0	COG3387@1|root,COG3387@2|Bacteria,2GJAD@201174|Actinobacteria,4D8XJ@85008|Micromonosporales	201174|Actinobacteria	G	Glycoside hydrolase 15-related	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_15
HKD2_k127_9228760_13	106370.Francci3_2247	1.052e-17	82.0	COG1960@1|root,COG1960@2|Bacteria,2GMEM@201174|Actinobacteria,4ERC3@85013|Frankiales	201174|Actinobacteria	I	acyl-CoA dehydrogenase	fadE19	GO:0000062,GO:0000166,GO:0003674,GO:0003824,GO:0003995,GO:0004085,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005759,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0006950,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009605,GO:0009719,GO:0009725,GO:0009987,GO:0009991,GO:0010033,GO:0014070,GO:0016020,GO:0016042,GO:0016043,GO:0016054,GO:0016491,GO:0016627,GO:0017076,GO:0019395,GO:0019605,GO:0019626,GO:0019752,GO:0022607,GO:0030258,GO:0030554,GO:0031090,GO:0031667,GO:0031960,GO:0031966,GO:0031967,GO:0031974,GO:0031975,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0033218,GO:0033539,GO:0033993,GO:0034440,GO:0036094,GO:0042221,GO:0042594,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046359,GO:0046395,GO:0046459,GO:0048037,GO:0048545,GO:0050660,GO:0050662,GO:0050896,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0051384,GO:0052890,GO:0055114,GO:0065003,GO:0070013,GO:0071704,GO:0071840,GO:0072329,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901567,GO:1901575,GO:1901681	1.3.8.1,1.3.99.12	ko:K00248,ko:K11410	ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212	-	R01175,R01178,R02661,R03172,R04751	RC00052,RC00068,RC00076,RC00120,RC00148	ko00000,ko00001,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HKD2_k127_9228760_8	426117.M446_5664	1.117e-61	239.0	2DBB9@1|root,2Z86U@2|Bacteria,1RC32@1224|Proteobacteria,2U6MI@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9228760_0	1111069.TCCBUS3UF1_16380	1.595e-206	652.0	COG0473@1|root,COG0473@2|Bacteria,1WIRG@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	Isocitrate isopropylmalate dehydrogenase	-	-	1.1.1.42	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00740	R00267,R00268,R01899	RC00001,RC00084,RC00114,RC00626,RC02801	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
HKD2_k127_9228760_9	35754.JNYJ01000052_gene6644	7.636e-33	130.0	COG1846@1|root,COG1846@2|Bacteria,2IMGG@201174|Actinobacteria,4DF47@85008|Micromonosporales	201174|Actinobacteria	K	MarR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_11,HTH_24,MarR_2
HKD2_k127_9228760_1	656024.FsymDg_0655	1.742e-189	613.0	COG1004@1|root,COG1004@2|Bacteria,2GJQB@201174|Actinobacteria,4ERE2@85013|Frankiales	201174|Actinobacteria	M	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	-	-	1.1.1.22	ko:K00012	ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100	M00014,M00129,M00361,M00362	R00286	RC00291	ko00000,ko00001,ko00002,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
HKD2_k127_9228760_7	710111.FraQA3DRAFT_3729	1.325e-65	244.0	COG0365@1|root,COG0365@2|Bacteria,2I2IW@201174|Actinobacteria,4ET0W@85013|Frankiales	201174|Actinobacteria	I	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding
HKD2_k127_9228760_6	222534.KB893683_gene1188	1.264e-79	281.0	COG0718@1|root,COG1316@1|root,COG0718@2|Bacteria,COG1316@2|Bacteria,2GJM3@201174|Actinobacteria,4ESMP@85013|Frankiales	201174|Actinobacteria	K	TIGRFAM cell envelope-related function transcriptional attenuator	cpsA	-	-	-	-	-	-	-	-	-	-	-	LytR_C,LytR_cpsA_psr
HKD2_k127_9228760_10	106370.Francci3_0711	7.762e-30	129.0	COG1316@1|root,COG1316@2|Bacteria,2GJM3@201174|Actinobacteria,4ESMP@85013|Frankiales	201174|Actinobacteria	K	TIGRFAM cell envelope-related function transcriptional attenuator	cpsA	-	-	-	-	-	-	-	-	-	-	-	LytR_C,LytR_cpsA_psr
HKD2_k127_9228760_4	656024.FsymDg_1037	1.421e-144	475.0	COG1316@1|root,COG1316@2|Bacteria,2GJM3@201174|Actinobacteria,4ESMP@85013|Frankiales	201174|Actinobacteria	K	TIGRFAM cell envelope-related function transcriptional attenuator	cpsA	-	-	-	-	-	-	-	-	-	-	-	LytR_C,LytR_cpsA_psr
HKD2_k127_9228760_2	656024.FsymDg_1038	6.391e-188	597.0	COG1209@1|root,COG1209@2|Bacteria,2GP20@201174|Actinobacteria,4ET4A@85013|Frankiales	201174|Actinobacteria	M	PFAM Nucleotidyl transferase	-	-	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
HKD2_k127_9228760_3	351607.Acel_0415	1.555e-173	549.0	COG1088@1|root,COG1088@2|Bacteria,2GNDU@201174|Actinobacteria,4ERZI@85013|Frankiales	201174|Actinobacteria	M	Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily	rfbB	-	4.2.1.46	ko:K01710	ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130	M00793	R06513	RC00402	ko00000,ko00001,ko00002,ko01000	-	-	-	GDP_Man_Dehyd
HKD2_k127_9228760_5	656024.FsymDg_1040	6.24e-126	439.0	COG1091@1|root,COG1091@2|Bacteria,2GNY8@201174|Actinobacteria,4ERZQ@85013|Frankiales	201174|Actinobacteria	M	Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose	rmlD	GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008831,GO:0009058,GO:0009059,GO:0009225,GO:0009226,GO:0009987,GO:0016051,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019305,GO:0019438,GO:0033692,GO:0034637,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044271,GO:0044281,GO:0045226,GO:0046379,GO:0046383,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901576	1.1.1.133,5.1.3.13	ko:K00067,ko:K01790	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R02777,R06514	RC00182,RC01531	ko00000,ko00001,ko00002,ko01000	-	-	-	RmlD_sub_bind
HKD2_k127_9228760_14	1122182.KB903813_gene2442	1.954e-14	80.0	2E73E@1|root,331MX@2|Bacteria,2IRHV@201174|Actinobacteria,4DKDP@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	RHH_1
HKD2_k127_9228760_15	1122182.KB903813_gene2441	9.961e-12	74.0	COG4634@1|root,COG4634@2|Bacteria,2GWC9@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9228760_11	886293.Sinac_2627	1.66e-26	127.0	COG4485@1|root,COG5617@1|root,COG4485@2|Bacteria,COG5617@2|Bacteria,2J236@203682|Planctomycetes	203682|Planctomycetes	S	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9228760_12	710111.FraQA3DRAFT_2078	9.744e-19	95.0	COG1807@1|root,COG1807@2|Bacteria,2H1H7@201174|Actinobacteria,4EW4Y@85013|Frankiales	201174|Actinobacteria	M	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9244610_3	1479623.JHEL01000014_gene2103	1.164e-09	63.0	COG1302@1|root,COG1302@2|Bacteria,2GUDF@201174|Actinobacteria	201174|Actinobacteria	S	Asp23 family, cell envelope-related function	-	-	-	-	-	-	-	-	-	-	-	-	Asp23
HKD2_k127_9244610_1	1137271.AZUM01000001_gene945	2.614e-18	91.0	2DVB6@1|root,33V3R@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K21687	-	-	-	-	ko00000	-	GH23	-	-
HKD2_k127_9244610_0	1114959.SZMC14600_15000	3.459e-26	123.0	2F1BY@1|root,33UCU@2|Bacteria,2H92I@201174|Actinobacteria,4E4PN@85010|Pseudonocardiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9244610_2	909613.UO65_6092	3.495e-10	62.0	COG0030@1|root,COG0030@2|Bacteria,2GKBT@201174|Actinobacteria,4DZH7@85010|Pseudonocardiales	201174|Actinobacteria	J	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
HKD2_k127_9247086_12	1122611.KB903939_gene534	5.723e-18	91.0	COG0490@1|root,COG0490@2|Bacteria,2IFBQ@201174|Actinobacteria,4EJDK@85012|Streptosporangiales	201174|Actinobacteria	P	TrkA-C domain	-	-	-	ko:K07228	-	-	-	-	ko00000	-	-	-	TrkA_C
HKD2_k127_9247086_7	106370.Francci3_0285	1.066e-54	207.0	COG0791@1|root,COG0791@2|Bacteria,2IFNI@201174|Actinobacteria,4EWEY@85013|Frankiales	201174|Actinobacteria	M	pfam nlp p60	-	-	-	-	-	-	-	-	-	-	-	-	NLPC_P60
HKD2_k127_9247086_5	656024.FsymDg_2173	4.47e-82	279.0	COG0558@1|root,COG0558@2|Bacteria,2GM3F@201174|Actinobacteria,4ESIK@85013|Frankiales	201174|Actinobacteria	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pgsA2	GO:0003674,GO:0003824,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008444,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016740,GO:0016772,GO:0016780,GO:0017169,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0045017,GO:0046474,GO:0046486,GO:0071704,GO:0090407,GO:1901576	2.7.8.41,2.7.8.5	ko:K00995,ko:K08744	ko00564,ko01100,map00564,map01100	-	R01801,R02030	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
HKD2_k127_9247086_0	298653.Franean1_5002	0.0	1289.0	COG1109@1|root,COG1208@1|root,COG1109@2|Bacteria,COG1208@2|Bacteria,2GKTE@201174|Actinobacteria,4ERX2@85013|Frankiales	201174|Actinobacteria	M	alpha beta alpha domain I	-	-	2.7.7.13,5.4.2.8	ko:K16881	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114,M00362	R00885,R01818	RC00002,RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase,PGM_PMM_I,PGM_PMM_II,PGM_PMM_III
HKD2_k127_9247086_11	561175.KB894096_gene499	4.223e-40	162.0	COG3879@1|root,COG3879@2|Bacteria,2GMS5@201174|Actinobacteria	201174|Actinobacteria	S	protein conserved in bacteria	-	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DUF881
HKD2_k127_9247086_9	1283283.ATXA01000001_gene780	1.012e-45	181.0	COG3856@1|root,COG3856@2|Bacteria,2IKJW@201174|Actinobacteria,4ESRN@85013|Frankiales	201174|Actinobacteria	S	Protein of unknown function (DUF1290)	sbp	-	-	-	-	-	-	-	-	-	-	-	DUF1290
HKD2_k127_9247086_13	455632.SGR_6144	0.0001887	52.0	COG3879@1|root,COG3879@2|Bacteria,2GJ3C@201174|Actinobacteria,41A6V@629295|Streptomyces griseus group	201174|Actinobacteria	S	Bacterial protein of unknown function (DUF881)	-	GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DUF881
HKD2_k127_9247086_10	298653.Franean1_4999	5.165e-41	166.0	COG3879@1|root,COG3879@2|Bacteria,2GJ3C@201174|Actinobacteria,4ESTK@85013|Frankiales	201174|Actinobacteria	S	Bacterial protein of unknown function (DUF881)	-	GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DUF881
HKD2_k127_9247086_8	656024.FsymDg_2175	7.891e-51	191.0	COG0509@1|root,COG0509@2|Bacteria,2IKN2@201174|Actinobacteria,4ESYX@85013|Frankiales	201174|Actinobacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	gcvH	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	iNJ661.Rv1826	GCV_H
HKD2_k127_9247086_2	298653.Franean1_4997	1.485e-90	305.0	COG1552@1|root,COG1716@1|root,COG1552@2|Bacteria,COG1716@2|Bacteria,2GK99@201174|Actinobacteria,4ESK3@85013|Frankiales	201174|Actinobacteria	T	FHA domain containing protein	garA	-	-	-	-	-	-	-	-	-	-	-	FHA,Yop-YscD_cpl,zinc_ribbon_2
HKD2_k127_9247086_6	656024.FsymDg_2177	3.595e-77	272.0	COG0789@1|root,COG0789@2|Bacteria,2HBV6@201174|Actinobacteria,4ESMT@85013|Frankiales	201174|Actinobacteria	K	PFAM regulatory protein, MerR	merR1	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464	-	-	-	-	-	-	-	-	-	-	MerR,MerR_1
HKD2_k127_9247086_3	656024.FsymDg_2178	1.343e-86	291.0	COG1259@1|root,COG1259@2|Bacteria,2GN26@201174|Actinobacteria,4ESIT@85013|Frankiales	201174|Actinobacteria	S	Bifunctional nuclease	-	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	ko:K08999	-	-	-	-	ko00000	-	-	-	DNase-RNase
HKD2_k127_9247086_4	365528.KB891102_gene4361	2.21e-82	285.0	COG0789@1|root,COG0789@2|Bacteria,2GM67@201174|Actinobacteria,4ESCD@85013|Frankiales	201174|Actinobacteria	K	SMART regulatory protein, MerR	merR2	-	-	-	-	-	-	-	-	-	-	-	MerR_1
HKD2_k127_9247086_1	1713.JOFV01000003_gene1453	8.731e-152	492.0	COG2223@1|root,COG2223@2|Bacteria,2GJ1I@201174|Actinobacteria,4F12Q@85016|Cellulomonadaceae	201174|Actinobacteria	P	Major Facilitator Superfamily	narK2	-	-	ko:K02575	ko00910,map00910	M00615	-	-	ko00000,ko00001,ko00002,ko02000	2.A.1.8	-	-	MFS_1,Sugar_tr
HKD2_k127_9249364_0	469371.Tbis_1673	6.548e-153	495.0	COG1940@1|root,COG1940@2|Bacteria,2IB2E@201174|Actinobacteria	201174|Actinobacteria	GK	ROK family	glcK	-	-	-	-	-	-	-	-	-	-	-	ROK
HKD2_k127_9249364_1	105425.BBPL01000002_gene6431	9.543e-18	84.0	COG0677@1|root,COG0677@2|Bacteria,2GK5K@201174|Actinobacteria,2NENN@228398|Streptacidiphilus	201174|Actinobacteria	M	UDP binding domain	-	-	1.1.1.136,1.1.1.336	ko:K02472,ko:K13015	ko00520,ko05111,map00520,map05111	-	R00421,R03317	RC00291	ko00000,ko00001,ko01000,ko01005	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
HKD2_k127_9251043_2	469383.Cwoe_3429	3.7e-12	80.0	COG1295@1|root,COG1295@2|Bacteria	2|Bacteria	S	lipopolysaccharide transmembrane transporter activity	-	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Virul_fac_BrkB
HKD2_k127_9251043_0	1122223.KB890688_gene1885	8.112e-275	883.0	COG3387@1|root,COG3387@2|Bacteria,1WIMA@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	G	Glucodextranase, domain N	-	-	3.2.1.3	ko:K01178	ko00500,ko01100,map00500,map01100	-	R01790,R01791,R06199	-	ko00000,ko00001,ko01000	-	GH15	-	Glucodextran_N,Glyco_hydro_15
HKD2_k127_9251043_1	365528.KB891244_gene6397	2.814e-111	366.0	COG1073@1|root,COG1926@1|root,COG1073@2|Bacteria,COG1926@2|Bacteria,2GJUU@201174|Actinobacteria,4ES6H@85013|Frankiales	201174|Actinobacteria	S	Phosphoribosyl transferase domain	-	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K07100	-	-	-	-	ko00000	-	-	-	DLH,Pribosyltran
HKD2_k127_9260788_14	479435.Kfla_6265	8.751e-21	99.0	COG1487@1|root,COG1487@2|Bacteria,2IGMY@201174|Actinobacteria,4DWEZ@85009|Propionibacteriales	201174|Actinobacteria	S	PIN domain	vapC	-	-	-	-	-	-	-	-	-	-	-	PIN
HKD2_k127_9260788_5	56110.Oscil6304_5994	1.599e-129	434.0	COG2223@1|root,COG2223@2|Bacteria,1G0NY@1117|Cyanobacteria,1H8IA@1150|Oscillatoriales	1117|Cyanobacteria	P	PFAM Major Facilitator Superfamily	nrtP	GO:0003674,GO:0005215,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015112,GO:0015113,GO:0015318,GO:0015698,GO:0015706,GO:0015707,GO:0022857,GO:0034220,GO:0051179,GO:0051234,GO:0055085,GO:0071705,GO:0098656,GO:1902025	-	ko:K02575	ko00910,map00910	M00615	-	-	ko00000,ko00001,ko00002,ko02000	2.A.1.8	-	-	MFS_1
HKD2_k127_9260788_9	710111.FraQA3DRAFT_5676	2.306e-33	146.0	COG2337@1|root,COG2337@2|Bacteria,2IM6R@201174|Actinobacteria,4EVXD@85013|Frankiales	201174|Actinobacteria	L	Toxic component of a toxin-antitoxin (TA) module	-	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0006139,GO:0006417,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0016070,GO:0016787,GO:0016788,GO:0017148,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0034641,GO:0040008,GO:0043170,GO:0044237,GO:0044238,GO:0045926,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:2000112,GO:2000113	-	ko:K07171	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PemK_toxin
HKD2_k127_9260788_17	1440774.Y900_021570	2.871e-14	76.0	COG2161@1|root,COG2161@2|Bacteria,2GV08@201174|Actinobacteria	201174|Actinobacteria	D	Antitoxin component of a toxin-antitoxin (TA) module	relB	GO:0003674,GO:0005488,GO:0005515,GO:0008150,GO:0040008,GO:0045927,GO:0048518,GO:0050789,GO:0065007,GO:0097351	-	ko:K19159	-	-	-	-	ko00000,ko02048	-	-	-	PhdYeFM_antitox
HKD2_k127_9260788_12	345341.KUTG_04348	1.989e-23	102.0	COG2026@1|root,COG2026@2|Bacteria,2GRQR@201174|Actinobacteria	201174|Actinobacteria	DJ	PFAM plasmid stabilization system	relE	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0019439,GO:0034641,GO:0034655,GO:0040008,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0045926,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0065007,GO:0071704,GO:0090304,GO:0090305,GO:1901360,GO:1901361,GO:1901575	-	-	-	-	-	-	-	-	-	-	ParE_toxin
HKD2_k127_9260788_10	106370.Francci3_0795	7.04e-32	142.0	COG2146@1|root,COG2146@2|Bacteria,2IQM4@201174|Actinobacteria,4EW95@85013|Frankiales	201174|Actinobacteria	C	TIGRFAM nitrite reductase NAD(P)H , small subunit	nirD	-	1.7.1.15	ko:K00363	ko00910,ko01120,map00910,map01120	M00530	R00787	RC00176	ko00000,ko00001,ko00002,ko01000	-	-	-	Rieske_2
HKD2_k127_9260788_0	1120950.KB892752_gene6208	0.0	1112.0	COG1251@1|root,COG1251@2|Bacteria,2GJ3U@201174|Actinobacteria,4DNQ5@85009|Propionibacteriales	201174|Actinobacteria	C	Nitrite reductase NAD(P)H , large subunit	nirB	-	1.7.1.15	ko:K00362	ko00910,ko01120,map00910,map01120	M00530	R00787	RC00176	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_BFD,NIR_SIR,NIR_SIR_ferr,Pyr_redox_2
HKD2_k127_9260788_7	1463885.KL578357_gene9894	4.542e-55	202.0	COG2188@1|root,COG2188@2|Bacteria,2GNG7@201174|Actinobacteria	201174|Actinobacteria	K	SMART regulatory protein GntR HTH	-	-	-	ko:K03710	-	-	-	-	ko00000,ko03000	-	-	-	GntR,UTRA
HKD2_k127_9260788_8	1206743.BAGM01000024_gene1922	9.229e-34	144.0	COG0454@1|root,COG0456@2|Bacteria,2IK8Z@201174|Actinobacteria,4G0IY@85025|Nocardiaceae	201174|Actinobacteria	K	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HKD2_k127_9260788_13	1449976.KALB_822	3.097e-21	100.0	2C1EN@1|root,338PR@2|Bacteria,2IN1E@201174|Actinobacteria,4E4PP@85010|Pseudonocardiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9260788_20	390989.JOEG01000001_gene4921	2.025e-08	62.0	2A9NV@1|root,30YVM@2|Bacteria,2HBJC@201174|Actinobacteria	201174|Actinobacteria	S	HicA toxin of bacterial toxin-antitoxin,	-	-	-	-	-	-	-	-	-	-	-	-	HicA_toxin
HKD2_k127_9260788_16	1120950.KB892787_gene150	3.557e-15	79.0	2BM5X@1|root,32FPI@2|Bacteria,2GSBE@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9260788_11	935866.JAER01000007_gene393	1.696e-23	104.0	COG2026@1|root,COG2026@2|Bacteria,2IRES@201174|Actinobacteria,4DVZ9@85009|Propionibacteriales	201174|Actinobacteria	DJ	ParE toxin of type II toxin-antitoxin system, parDE	-	-	-	ko:K06218	-	-	-	-	ko00000,ko02048	-	-	-	ParE_toxin
HKD2_k127_9260788_4	58123.JOFJ01000006_gene286	5.688e-149	514.0	COG1251@1|root,COG1251@2|Bacteria,2GJ3U@201174|Actinobacteria,4EFSJ@85012|Streptosporangiales	201174|Actinobacteria	C	BFD-like [2Fe-2S] binding domain	nasC	-	-	ko:K00360	ko00910,ko01120,map00910,map01120	M00531	R00798	RC02812	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_BFD,Pyr_redox_2
HKD2_k127_9260788_1	106370.Francci3_0863	3.248e-319	990.0	COG3383@1|root,COG3383@2|Bacteria,2HC9H@201174|Actinobacteria,4ERF8@85013|Frankiales	201174|Actinobacteria	C	Molybdopterin oxidoreductase Fe4S4 domain	nasC	-	-	ko:K00372	ko00910,ko01120,map00910,map01120	M00531	R00798,R01106	RC02812	ko00000,ko00001,ko00002,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
HKD2_k127_9260788_3	298655.KI912267_gene7592	6.014e-158	539.0	COG0745@1|root,COG1587@1|root,COG0745@2|Bacteria,COG1587@2|Bacteria,2GKMM@201174|Actinobacteria,4ESGJ@85013|Frankiales	201174|Actinobacteria	HKT	Uroporphyrinogen III synthase HEM4	hemD	-	4.2.1.75	ko:K01719	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R03165	RC01861	ko00000,ko00001,ko00002,ko01000	-	-	-	HEM4,Trans_reg_C
HKD2_k127_9260788_2	1382306.JNIM01000001_gene2330	1.246e-236	747.0	COG0365@1|root,COG0365@2|Bacteria,2G83G@200795|Chloroflexi	200795|Chloroflexi	I	Acetyl-coenzyme A synthetase N-terminus	-	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
HKD2_k127_9260788_6	106370.Francci3_2874	2.68e-128	430.0	COG0515@1|root,COG0515@2|Bacteria,2GIV0@201174|Actinobacteria,4ES3X@85013|Frankiales	201174|Actinobacteria	KLT	Serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	Lipoprotein_21,Pkinase
HKD2_k127_9260788_21	928724.SacglDRAFT_03688	0.0003034	46.0	COG3293@1|root,COG3293@2|Bacteria,2IIAY@201174|Actinobacteria,4E3DP@85010|Pseudonocardiales	201174|Actinobacteria	L	PFAM Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_2,DUF4096
HKD2_k127_9260788_15	526225.Gobs_3532	5.157e-17	80.0	COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,2GJQI@201174|Actinobacteria,4ERUS@85013|Frankiales	201174|Actinobacteria	L	manually curated	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_28,HTH_29,HTH_32
HKD2_k127_9262622_1	479431.Namu_3688	3.319e-162	519.0	COG4221@1|root,COG4221@2|Bacteria,2I2YS@201174|Actinobacteria,4EXBN@85013|Frankiales	201174|Actinobacteria	S	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HKD2_k127_9262622_0	405948.SACE_2487	6.858e-241	775.0	COG3387@1|root,COG3387@2|Bacteria,2GJAD@201174|Actinobacteria,4DX52@85010|Pseudonocardiales	201174|Actinobacteria	G	Glycosyl hydrolases family 15	-	-	3.2.1.3	ko:K01178	ko00500,ko01100,map00500,map01100	-	R01790,R01791,R06199	-	ko00000,ko00001,ko01000	-	GH15	-	Glyco_hydro_15
HKD2_k127_9262622_2	391037.Sare_1075	0.0008668	53.0	2BF6Q@1|root,2ZWA6@2|Bacteria,2GZQU@201174|Actinobacteria,4DGPF@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9268424_3	1123023.JIAI01000002_gene5422	2.186e-08	62.0	COG5516@1|root,COG5516@2|Bacteria,2I9ZA@201174|Actinobacteria,4E5KK@85010|Pseudonocardiales	201174|Actinobacteria	S	Putative stress-induced transcription regulator	-	-	-	-	-	-	-	-	-	-	-	-	ABATE,zf-CGNR
HKD2_k127_9268424_1	266117.Rxyl_2946	2.972e-71	263.0	COG2197@1|root,COG3903@1|root,COG2197@2|Bacteria,COG3903@2|Bacteria,2GIZ1@201174|Actinobacteria,4CPZ0@84995|Rubrobacteria	84995|Rubrobacteria	T	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	BTAD,Trans_reg_C
HKD2_k127_9268424_0	33876.JNXY01000009_gene8908	1.634e-123	435.0	COG3629@1|root,COG3903@1|root,COG3629@2|Bacteria,COG3903@2|Bacteria,2GIZ1@201174|Actinobacteria,4DH3V@85008|Micromonosporales	201174|Actinobacteria	KT	Transcriptional regulator	-	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	GerE,Guanylate_cyc,NB-ARC
HKD2_k127_9268424_2	33876.JNXY01000009_gene8908	6.129e-25	119.0	COG3629@1|root,COG3903@1|root,COG3629@2|Bacteria,COG3903@2|Bacteria,2GIZ1@201174|Actinobacteria,4DH3V@85008|Micromonosporales	201174|Actinobacteria	KT	Transcriptional regulator	-	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	GerE,Guanylate_cyc,NB-ARC
HKD2_k127_9274542_10	298654.FraEuI1c_0934	3.021e-47	173.0	COG0356@1|root,COG0356@2|Bacteria,2H3PR@201174|Actinobacteria,4ETD3@85013|Frankiales	201174|Actinobacteria	C	it plays a direct role in the translocation of protons across the membrane	atpB	-	-	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1	-	-	ATP-synt_A
HKD2_k127_9274542_12	710111.FraQA3DRAFT_5667	1.235e-18	94.0	2DF3C@1|root,2ZQAW@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K02116	-	-	-	-	ko00000,ko00194	3.A.2.1	-	-	-
HKD2_k127_9274542_11	656024.FsymDg_3851	1.077e-30	137.0	2DSZR@1|root,33I3C@2|Bacteria,2GXTX@201174|Actinobacteria,4EWSF@85013|Frankiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9274542_3	656024.FsymDg_3852	1.343e-170	544.0	COG0472@1|root,COG0472@2|Bacteria,2GIT7@201174|Actinobacteria,4ERX0@85013|Frankiales	201174|Actinobacteria	M	PFAM Glycosyl transferase family 4	rfe	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016043,GO:0016740,GO:0016772,GO:0016780,GO:0030145,GO:0034645,GO:0042546,GO:0043167,GO:0043169,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044464,GO:0045229,GO:0046872,GO:0046914,GO:0070589,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0071944,GO:1901576	2.7.8.33,2.7.8.35	ko:K02851	-	-	R08856	RC00002	ko00000,ko01000,ko01003,ko01005	-	-	-	Glycos_transf_4
HKD2_k127_9274542_0	656024.FsymDg_3853	1.031e-239	750.0	COG0112@1|root,COG0112@2|Bacteria,2GK7U@201174|Actinobacteria,4ERC5@85013|Frankiales	201174|Actinobacteria	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
HKD2_k127_9274542_5	710111.FraQA3DRAFT_2738	2.035e-149	494.0	COG0654@1|root,COG0654@2|Bacteria,2GK88@201174|Actinobacteria	201174|Actinobacteria	CH	PFAM monooxygenase FAD-binding	-	-	1.14.13.127	ko:K05712	ko00360,ko01120,ko01220,map00360,map01120,map01220	M00545	R06786,R06787	RC00236	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_3
HKD2_k127_9274542_8	656024.FsymDg_3854	2.284e-90	302.0	COG0009@1|root,COG0009@2|Bacteria,2GK2X@201174|Actinobacteria,4ESEK@85013|Frankiales	201174|Actinobacteria	J	Belongs to the SUA5 family	ywlC	GO:0000049,GO:0002949,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006450,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0065007,GO:0065008,GO:0070525,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363	2.7.7.87	ko:K07566	-	-	R10463	RC00745	ko00000,ko01000,ko03009,ko03016	-	-	-	Sua5_yciO_yrdC
HKD2_k127_9274542_7	106370.Francci3_3719	7.224e-98	334.0	COG2890@1|root,COG2890@2|Bacteria,2GMH1@201174|Actinobacteria,4ESEI@85013|Frankiales	201174|Actinobacteria	J	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif	prmC	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0016740,GO:0016741,GO:0032259,GO:0044424,GO:0044444,GO:0044464	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS,Methyltransf_25,Methyltransf_31
HKD2_k127_9274542_4	326424.FRAAL5945	2.956e-158	524.0	COG0216@1|root,COG0216@2|Bacteria,2GJWG@201174|Actinobacteria,4ES20@85013|Frankiales	201174|Actinobacteria	J	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA	prfA	GO:0008150,GO:0040007	-	ko:K02835	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
HKD2_k127_9274542_1	1146883.BLASA_3933	2.906e-232	737.0	COG1158@1|root,COG1158@2|Bacteria,2GIWY@201174|Actinobacteria,4ERDG@85013|Frankiales	201174|Actinobacteria	K	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template	rho	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006351,GO:0006353,GO:0006360,GO:0006363,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0018130,GO:0019438,GO:0030312,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576	-	ko:K03628	ko03018,map03018	-	-	-	ko00000,ko00001,ko03019,ko03021	-	-	-	ATP-synt_ab,Rho_N,Rho_RNA_bind
HKD2_k127_9274542_9	1123322.KB904663_gene4059	7.769e-90	321.0	COG0083@1|root,COG0083@2|Bacteria,2GKIW@201174|Actinobacteria	201174|Actinobacteria	E	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate	thrB	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004413,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006555,GO:0006566,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009088,GO:0009092,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019202,GO:0019752,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.1.39	ko:K00872	ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230	M00018	R01771	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
HKD2_k127_9274542_2	656024.FsymDg_3860	6.172e-171	542.0	COG0498@1|root,COG0498@2|Bacteria,2GJ5F@201174|Actinobacteria,4ES1B@85013|Frankiales	201174|Actinobacteria	E	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine	thrC	GO:0003674,GO:0003824,GO:0004795,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006566,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009088,GO:0009987,GO:0016020,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HKD2_k127_9274542_6	656024.FsymDg_3861	9.692e-141	450.0	COG0460@1|root,COG0460@2|Bacteria,2GIX9@201174|Actinobacteria,4ERJB@85013|Frankiales	201174|Actinobacteria	E	homoserine dehydrogenase	hom	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	1.1.1.3,2.7.2.4	ko:K00003,ko:K12524	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00017,M00018,M00526,M00527	R00480,R01773,R01775	RC00002,RC00043,RC00087	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv1294	ACT,Homoserine_dh,NAD_binding_3
HKD2_k127_9297991_2	298653.Franean1_6144	3.154e-73	262.0	COG0248@1|root,COG0248@2|Bacteria,2GMME@201174|Actinobacteria,4ETV1@85013|Frankiales	201174|Actinobacteria	FP	PFAM Ppx GppA phosphatase	ppx1	GO:0003674,GO:0003824,GO:0006793,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0044237	3.6.1.11,3.6.1.40	ko:K01524	ko00230,map00230	-	R03409	RC00002	ko00000,ko00001,ko01000	-	-	-	Ppx-GppA
HKD2_k127_9297991_1	326424.FRAAL0967	4.208e-123	396.0	COG0745@1|root,COG0745@2|Bacteria,2GKFS@201174|Actinobacteria,4ERYJ@85013|Frankiales	201174|Actinobacteria	T	Response regulator receiver	regX3	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009405,GO:0009889,GO:0010468,GO:0010556,GO:0010565,GO:0019216,GO:0019217,GO:0019219,GO:0019220,GO:0019222,GO:0031323,GO:0031326,GO:0044419,GO:0048583,GO:0050789,GO:0050794,GO:0051171,GO:0051174,GO:0051252,GO:0051704,GO:0060255,GO:0062012,GO:0065007,GO:0080090,GO:0080134,GO:0097159,GO:1901363,GO:1902882,GO:1903506,GO:2000112,GO:2001141	-	ko:K07776	ko02020,map02020	M00443	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
HKD2_k127_9297991_0	656024.FsymDg_4067	8.822e-149	480.0	COG5002@1|root,COG5002@2|Bacteria,2GJY7@201174|Actinobacteria,4EREU@85013|Frankiales	201174|Actinobacteria	T	Histidine kinase	senX3	GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009405,GO:0009987,GO:0016020,GO:0016310,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044419,GO:0044464,GO:0046777,GO:0051704,GO:0071704,GO:0071944,GO:1901564	2.7.13.3	ko:K07768	ko02020,map02020	M00443	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA
HKD2_k127_9297991_3	656024.FsymDg_4068	6.002e-62	217.0	COG0704@1|root,COG0704@2|Bacteria,2GKAD@201174|Actinobacteria,4ESDP@85013|Frankiales	201174|Actinobacteria	P	Plays a role in the regulation of phosphate uptake	phoU	-	-	ko:K02039	-	-	-	-	ko00000	-	-	-	PhoU
HKD2_k127_9308621_1	1449976.KALB_4140	3.202e-55	201.0	29KBT@1|root,30793@2|Bacteria,2IE0E@201174|Actinobacteria,4E3KH@85010|Pseudonocardiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	vATP-synt_AC39
HKD2_k127_9308621_0	55952.BU52_26000	7.684e-90	316.0	COG1269@1|root,COG1269@2|Bacteria,2I9VH@201174|Actinobacteria	201174|Actinobacteria	C	V-type ATPase 116kDa subunit family	-	-	-	ko:K02123	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	V_ATPase_I
HKD2_k127_9320998_1	656024.FsymDg_1796	5.648e-146	488.0	COG1160@1|root,COG1160@2|Bacteria,2GJ8J@201174|Actinobacteria,4ERXN@85013|Frankiales	201174|Actinobacteria	S	GTPase that plays an essential role in the late steps of ribosome biogenesis	der	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	-	ko:K03977	-	-	-	-	ko00000,ko03009	-	-	-	Cytidylate_kin,KH_dom-like,MMR_HSR1
HKD2_k127_9320998_4	298655.KI912266_gene3476	2.731e-88	304.0	COG0204@1|root,COG0204@2|Bacteria,2GP8A@201174|Actinobacteria,4EWE0@85013|Frankiales	201174|Actinobacteria	I	PFAM Phospholipid glycerol acyltransferase	-	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
HKD2_k127_9320998_5	222534.KB893671_gene3387	1.085e-86	293.0	COG0283@1|root,COG0283@2|Bacteria,2H3SI@201174|Actinobacteria,4ESQY@85013|Frankiales	201174|Actinobacteria	F	Belongs to the cytidylate kinase family. Type 1 subfamily	cmk	GO:0003674,GO:0003824,GO:0004127,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006573,GO:0006575,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0034654,GO:0040007,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046939,GO:0046940,GO:0050145,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	2.7.4.25	ko:K00945	ko00240,ko01100,map00240,map01100	M00052	R00158,R00512,R01665	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytidylate_kin
HKD2_k127_9320998_0	656024.FsymDg_1793	7.689e-149	484.0	COG0287@1|root,COG0287@2|Bacteria,2GKB4@201174|Actinobacteria,4ETEP@85013|Frankiales	201174|Actinobacteria	E	prephenate dehydrogenase	tyrA	-	1.3.1.12	ko:K04517	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	M00025	R01728	RC00125	ko00000,ko00001,ko00002,ko01000	-	-	-	PDH
HKD2_k127_9320998_7	1123024.AUII01000041_gene1731	3.442e-50	181.0	COG4401@1|root,COG4401@2|Bacteria,2IHWT@201174|Actinobacteria,4E4D4@85010|Pseudonocardiales	201174|Actinobacteria	E	Chorismate mutase type I	-	-	5.4.99.5	ko:K06208	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024,M00025	R01715	RC03116	ko00000,ko00001,ko00002,ko01000	-	-	-	CM_1
HKD2_k127_9320998_3	656024.FsymDg_1792	1.391e-106	359.0	COG1187@1|root,COG1187@2|Bacteria,2GJ4N@201174|Actinobacteria,4ERXR@85013|Frankiales	201174|Actinobacteria	J	Belongs to the pseudouridine synthase RsuA family	rluB	GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360	5.4.99.19,5.4.99.22	ko:K06178,ko:K06183	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
HKD2_k127_9320998_6	298654.FraEuI1c_2929	5.776e-72	247.0	COG1386@1|root,COG1386@2|Bacteria,2GISY@201174|Actinobacteria,4ESM8@85013|Frankiales	201174|Actinobacteria	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves	scpB	-	-	ko:K06024	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpB
HKD2_k127_9320998_2	326424.FRAAL2249	1.239e-113	374.0	COG1354@1|root,COG1354@2|Bacteria,2GN1U@201174|Actinobacteria,4ERDV@85013|Frankiales	201174|Actinobacteria	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves	scpA	-	-	ko:K05896	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpA
HKD2_k127_9320998_8	106370.Francci3_1451	1.998e-10	61.0	COG1994@1|root,COG1994@2|Bacteria,2GZ4H@201174|Actinobacteria	201174|Actinobacteria	S	Peptidase M50	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9331395_7	656024.FsymDg_0914	5.288e-14	72.0	COG0612@1|root,COG0612@2|Bacteria,2GJZ3@201174|Actinobacteria,4ERZ0@85013|Frankiales	201174|Actinobacteria	S	PFAM Peptidase M16	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
HKD2_k127_9331395_0	656024.FsymDg_0916	9.183e-178	572.0	COG0612@1|root,COG0612@2|Bacteria,2GKAT@201174|Actinobacteria,4ERQ4@85013|Frankiales	201174|Actinobacteria	S	PFAM Peptidase M16	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
HKD2_k127_9331395_2	469371.Tbis_2968	1.703e-72	266.0	COG2816@1|root,COG2816@2|Bacteria,2GJZY@201174|Actinobacteria,4DXT4@85010|Pseudonocardiales	201174|Actinobacteria	L	NADH pyrophosphatase	nudC	-	3.6.1.22	ko:K03426	ko00760,ko01100,ko04146,map00760,map01100,map04146	-	R00103,R03004,R11104	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX,NUDIX-like,zf-NADH-PPase
HKD2_k127_9331395_3	656024.FsymDg_0917	6.935e-72	253.0	COG2203@1|root,COG3707@1|root,COG2203@2|Bacteria,COG3707@2|Bacteria,2H887@201174|Actinobacteria,4EWSQ@85013|Frankiales	201174|Actinobacteria	K	ANTAR	-	-	-	-	-	-	-	-	-	-	-	-	ANTAR
HKD2_k127_9331395_4	285535.JOEY01000001_gene5208	1.181e-28	117.0	COG0695@1|root,COG0695@2|Bacteria,2IQF9@201174|Actinobacteria	201174|Actinobacteria	O	Glutaredoxin	-	-	1.20.4.3	ko:K18917	-	-	-	-	ko00000,ko01000	-	-	-	Glutaredoxin
HKD2_k127_9331395_1	1120950.KB892820_gene713	4.083e-97	343.0	COG1476@1|root,COG2856@1|root,COG1476@2|Bacteria,COG2856@2|Bacteria,2GRH0@201174|Actinobacteria,4DNF5@85009|Propionibacteriales	201174|Actinobacteria	K	IrrE N-terminal-like domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3,HTH_31,Peptidase_M78
HKD2_k127_9331395_6	103733.JNYO01000010_gene6369	6.181e-19	90.0	COG0210@1|root,COG0210@2|Bacteria,2GKRW@201174|Actinobacteria,4DXMZ@85010|Pseudonocardiales	201174|Actinobacteria	L	helicase	uvrD2	GO:0000287,GO:0003674,GO:0003678,GO:0003824,GO:0004386,GO:0005488,GO:0006996,GO:0008094,GO:0008150,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0040007,GO:0042623,GO:0043167,GO:0043169,GO:0046872,GO:0051276,GO:0071103,GO:0071840,GO:0140097	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HRDC,UvrD-helicase,UvrD_C
HKD2_k127_9332415_2	479435.Kfla_0305	2.836e-72	263.0	COG2199@1|root,COG2202@1|root,COG2203@1|root,COG2199@2|Bacteria,COG2202@2|Bacteria,COG2203@2|Bacteria,2GJNM@201174|Actinobacteria,4DRQP@85009|Propionibacteriales	201174|Actinobacteria	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,GGDEF,PAS,PAS_3,PAS_4,PAS_8,PAS_9
HKD2_k127_9332415_0	656024.FsymDg_0089	1.095e-300	940.0	COG2844@1|root,COG2844@2|Bacteria,2GMKT@201174|Actinobacteria,4ERG2@85013|Frankiales	201174|Actinobacteria	O	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen	glnD	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008773,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0030312,GO:0044464,GO:0070566,GO:0070569,GO:0071944,GO:0140096	2.7.7.59	ko:K00990	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	-	-	-	ACT,GlnD_UR_UTase,HD,NTP_transf_2
HKD2_k127_9332415_3	351607.Acel_1565	2.52e-47	192.0	COG0347@1|root,COG0347@2|Bacteria,2IKN1@201174|Actinobacteria,4ESRI@85013|Frankiales	201174|Actinobacteria	K	Belongs to the P(II) protein family	glnB	GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0008144,GO:0008150,GO:0016020,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043531,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044464,GO:0051704,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K04751	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	P-II
HKD2_k127_9332415_1	298654.FraEuI1c_2072	4.211e-192	610.0	COG0004@1|root,COG0004@2|Bacteria,2GIZK@201174|Actinobacteria,4ERCB@85013|Frankiales	201174|Actinobacteria	P	Ammonium Transporter	amtB	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp,P-II
HKD2_k127_9337223_3	1476876.JOJO01000053_gene15	1.325e-80	281.0	COG3173@1|root,COG3173@2|Bacteria	2|Bacteria	S	very-long-chain-acyl-CoA dehydrogenase activity	aph	-	-	-	-	-	-	-	-	-	-	-	APH
HKD2_k127_9337223_4	35754.JNYJ01000067_gene4112	3.49e-60	214.0	2C3NF@1|root,30ZWG@2|Bacteria,2IFY6@201174|Actinobacteria,4DCQJ@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF1772
HKD2_k127_9337223_7	656024.FsymDg_3591	9.04e-29	119.0	2C4MW@1|root,32RKK@2|Bacteria,2IQ6A@201174|Actinobacteria,4ETF6@85013|Frankiales	201174|Actinobacteria	S	Lsr2	lsr	-	-	-	-	-	-	-	-	-	-	-	Lsr2
HKD2_k127_9337223_1	1386089.N865_02545	1.821e-141	466.0	COG4941@1|root,COG4941@2|Bacteria,2GJ36@201174|Actinobacteria	201174|Actinobacteria	K	belongs to the sigma-70 factor family	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD2_k127_9337223_6	1386089.N865_02550	4.707e-37	144.0	COG3795@1|root,COG3795@2|Bacteria,2IQXT@201174|Actinobacteria,4FI0Y@85021|Intrasporangiaceae	201174|Actinobacteria	S	YCII-related domain	-	-	-	-	-	-	-	-	-	-	-	-	YCII
HKD2_k127_9337223_2	469383.Cwoe_4299	9.218e-109	366.0	COG2030@1|root,COG2030@2|Bacteria,2GKFH@201174|Actinobacteria,4CRUT@84995|Rubrobacteria	84995|Rubrobacteria	I	Acyl dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9337223_0	326427.Cagg_1329	7.797e-176	559.0	COG1804@1|root,COG1804@2|Bacteria,2GAJJ@200795|Chloroflexi,376IJ@32061|Chloroflexia	32061|Chloroflexia	C	CoA-transferase family III	-	GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0015977,GO:0016853,GO:0016866,GO:0016867,GO:0043427,GO:0071704	5.4.1.3	ko:K14470	ko00720,ko01120,ko01200,map00720,map01120,map01200	M00376	R09283	RC02480	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_transf_3
HKD2_k127_9337223_5	106370.Francci3_0948	2.557e-57	211.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,2GIV0@201174|Actinobacteria,4ES3X@85013|Frankiales	201174|Actinobacteria	KLT	Serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Pkinase
HKD2_k127_9360119_5	446469.Sked_01660	2.748e-50	186.0	COG1277@1|root,COG1277@2|Bacteria,2GP6D@201174|Actinobacteria	201174|Actinobacteria	S	ABC transporter (Permease)	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2,ABC2_membrane_4
HKD2_k127_9360119_0	1121946.AUAX01000012_gene6578	9.129e-115	398.0	COG1131@1|root,COG1131@2|Bacteria,2GN8P@201174|Actinobacteria,4DB9P@85008|Micromonosporales	201174|Actinobacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD2_k127_9360119_3	1120950.KB892769_gene5419	6.315e-75	286.0	COG2834@1|root,COG2834@2|Bacteria,2GKA2@201174|Actinobacteria,4DQPS@85009|Propionibacteriales	201174|Actinobacteria	M	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2092,MucB_RseB
HKD2_k127_9360119_1	356851.JOAN01000008_gene2924	1.017e-91	306.0	COG0745@1|root,COG0745@2|Bacteria,2GMG9@201174|Actinobacteria,4DARZ@85008|Micromonosporales	201174|Actinobacteria	T	response regulator	-	-	-	ko:K07665	ko02020,map02020	M00452,M00745	-	-	ko00000,ko00001,ko00002,ko01504,ko02022	-	-	-	Response_reg,Trans_reg_C
HKD2_k127_9360119_2	590998.Celf_1318	2.829e-85	302.0	COG4251@1|root,COG4251@2|Bacteria,2I6BW@201174|Actinobacteria,4F31M@85016|Cellulomonadaceae	201174|Actinobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
HKD2_k127_9360119_6	525368.HMPREF0591_2243	8.817e-25	109.0	2FG55@1|root,3481N@2|Bacteria,2I83I@201174|Actinobacteria	201174|Actinobacteria	S	Bacterial antitoxin of type II TA system, VapB	-	-	-	-	-	-	-	-	-	-	-	-	VapB_antitoxin
HKD2_k127_9360119_4	525368.HMPREF0591_2244	1.12e-60	215.0	COG1487@1|root,COG1487@2|Bacteria,2ISE2@201174|Actinobacteria,23B4F@1762|Mycobacteriaceae	201174|Actinobacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	GO:0003674,GO:0003824,GO:0004518,GO:0004540,GO:0006139,GO:0006417,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009605,GO:0009607,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0016070,GO:0016787,GO:0016788,GO:0017148,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0034641,GO:0040008,GO:0043170,GO:0043207,GO:0044237,GO:0044238,GO:0044403,GO:0044419,GO:0045926,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0051701,GO:0051704,GO:0051707,GO:0060255,GO:0065007,GO:0071704,GO:0075136,GO:0080090,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360,GO:2000112,GO:2000113	-	-	-	-	-	-	-	-	-	-	PIN
HKD2_k127_9360119_7	469383.Cwoe_4956	3.81e-08	61.0	2AKFC@1|root,31B6X@2|Bacteria,2GV4J@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9370449_0	397278.JOJN01000018_gene3508	8.322e-90	304.0	COG5002@1|root,COG5002@2|Bacteria,2GIX7@201174|Actinobacteria,4DP74@85009|Propionibacteriales	201174|Actinobacteria	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
HKD2_k127_9379479_11	656024.FsymDg_3289	4.495e-58	205.0	COG0292@1|root,COG0292@2|Bacteria,2IHTN@201174|Actinobacteria,4ESXY@85013|Frankiales	201174|Actinobacteria	J	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit	rplT	GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006996,GO:0008150,GO:0009987,GO:0015934,GO:0016020,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:0071944,GO:1990904	-	ko:K02887	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L20
HKD2_k127_9379479_13	222534.KB893694_gene162	2.015e-20	94.0	COG0291@1|root,COG0291@2|Bacteria,2GQZW@201174|Actinobacteria,4ETHR@85013|Frankiales	201174|Actinobacteria	J	Belongs to the bacterial ribosomal protein bL35 family	rpmI	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02916	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L35p
HKD2_k127_9379479_6	710111.FraQA3DRAFT_6320	4.031e-101	334.0	COG0290@1|root,COG0290@2|Bacteria,2GJGT@201174|Actinobacteria,4ESDW@85013|Frankiales	201174|Actinobacteria	J	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins	infC	GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0006996,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022411,GO:0032790,GO:0032984,GO:0032988,GO:0034641,GO:0034645,GO:0040007,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008	-	ko:K02520	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	IF3_C,IF3_N
HKD2_k127_9379479_12	1169152.AXVD01000019_gene789	1.8e-42	167.0	COG1309@1|root,COG1309@2|Bacteria,2I0IN@201174|Actinobacteria,4G8UQ@85025|Nocardiaceae	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
HKD2_k127_9379479_10	216594.MMAR_1944	8.875e-64	242.0	COG3177@1|root,COG3177@2|Bacteria,2GS07@201174|Actinobacteria	201174|Actinobacteria	S	Filamentation induced by cAMP protein fic	-	-	-	-	-	-	-	-	-	-	-	-	Fic
HKD2_k127_9379479_2	1120936.KB907210_gene5760	1.508e-132	428.0	COG0040@1|root,COG0040@2|Bacteria,2GNAX@201174|Actinobacteria,4EGFE@85012|Streptosporangiales	201174|Actinobacteria	E	ATP phosphoribosyltransferase	hisG	-	2.4.2.17	ko:K00765	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002,ko01000	-	-	-	HisG,HisG_C
HKD2_k127_9379479_9	656024.FsymDg_3297	2.18e-64	228.0	COG0054@1|root,COG0054@2|Bacteria,2II1Z@201174|Actinobacteria,4ESTJ@85013|Frankiales	201174|Actinobacteria	H	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin	ribH	GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0040007,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.78	ko:K00794	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R04457	RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	DMRL_synthase
HKD2_k127_9379479_0	656024.FsymDg_3298	5.439e-209	667.0	COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,2GIWJ@201174|Actinobacteria,4ERH4@85013|Frankiales	201174|Actinobacteria	H	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate	ribBA	-	3.5.4.25,4.1.99.12	ko:K14652	ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110	M00125,M00840	R00425,R07281	RC00293,RC01792,RC01815,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	-	DHBP_synthase,GTP_cyclohydro2
HKD2_k127_9379479_8	656024.FsymDg_3299	3.066e-74	255.0	COG0307@1|root,COG0307@2|Bacteria,2GKC5@201174|Actinobacteria,4ESRK@85013|Frankiales	201174|Actinobacteria	H	riboflavin synthase, alpha	ribE	GO:0003674,GO:0003824,GO:0004746,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.9	ko:K00793	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00066	RC00958,RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	Lum_binding
HKD2_k127_9379479_5	28444.JODQ01000001_gene2189	2.905e-113	407.0	COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,2GKAX@201174|Actinobacteria,4EI84@85012|Streptosporangiales	201174|Actinobacteria	H	RibD C-terminal domain	ribD	-	1.1.1.193,3.5.4.26	ko:K00082,ko:K11752	ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024	M00125	R03458,R03459	RC00204,RC00933	ko00000,ko00001,ko00002,ko01000	-	-	-	RibD_C,dCMP_cyt_deam_1
HKD2_k127_9379479_4	222534.KB893694_gene155	1.094e-116	378.0	COG0036@1|root,COG0036@2|Bacteria,2GJZ9@201174|Actinobacteria,4ERMA@85013|Frankiales	201174|Actinobacteria	G	Belongs to the ribulose-phosphate 3-epimerase family	rpe	GO:0003674,GO:0003824,GO:0004750,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009052,GO:0009056,GO:0009117,GO:0009987,GO:0016052,GO:0016853,GO:0016854,GO:0016857,GO:0019321,GO:0019323,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046483,GO:0046496,GO:0046872,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564,GO:1901575	5.1.3.1	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
HKD2_k127_9379479_1	326424.FRAAL5224	9.694e-176	578.0	COG0144@1|root,COG0781@1|root,COG0144@2|Bacteria,COG0781@2|Bacteria,2GM21@201174|Actinobacteria,4ERXE@85013|Frankiales	201174|Actinobacteria	JK	Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family	fmu	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008173,GO:0008649,GO:0008757,GO:0009383,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0030312,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.176	ko:K03500	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltr_RsmB-F,NusB
HKD2_k127_9379479_3	471852.Tcur_3000	2.655e-130	422.0	COG0223@1|root,COG0223@2|Bacteria,2GKH5@201174|Actinobacteria,4EHUK@85012|Streptosporangiales	201174|Actinobacteria	J	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus	fmt	GO:0003674,GO:0003824,GO:0004479,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006413,GO:0006464,GO:0006518,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016742,GO:0019538,GO:0019988,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0040007,GO:0043043,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0071704,GO:0071951,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	-	Formyl_trans_C,Formyl_trans_N
HKD2_k127_9379479_7	656024.FsymDg_3307	2.741e-91	301.0	COG0242@1|root,COG0242@2|Bacteria,2GJ87@201174|Actinobacteria,4ESF2@85013|Frankiales	201174|Actinobacteria	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions	def	-	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	Pep_deformylase
HKD2_k127_9391454_3	710111.FraQA3DRAFT_1043	5.926e-30	128.0	COG0711@1|root,COG0711@2|Bacteria,2IQQZ@201174|Actinobacteria,4EW8R@85013|Frankiales	201174|Actinobacteria	C	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9391454_2	1068978.AMETH_0580	4.528e-33	134.0	2DMSR@1|root,32TF3@2|Bacteria,2IR08@201174|Actinobacteria,4E648@85010|Pseudonocardiales	201174|Actinobacteria	S	Putative Actinobacterial Holin-X, holin superfamily III	-	-	-	-	-	-	-	-	-	-	-	-	Phage_holin_3_6
HKD2_k127_9391454_0	710111.FraQA3DRAFT_1041	8.013e-52	199.0	2B9CE@1|root,322Q4@2|Bacteria,2IKT2@201174|Actinobacteria,4EVWZ@85013|Frankiales	201174|Actinobacteria	S	Protein of unknown function (DUF3618)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3618
HKD2_k127_9391454_1	710111.FraQA3DRAFT_0956	1.429e-40	152.0	COG0859@1|root,COG0859@2|Bacteria,2GMZG@201174|Actinobacteria,4EVAQ@85013|Frankiales	201174|Actinobacteria	M	Glycosyltransferase family 9 (heptosyltransferase)	-	-	-	ko:K02843	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9
HKD2_k127_9419333_2	710111.FraQA3DRAFT_5624	9.757e-54	190.0	COG1191@1|root,COG1191@2|Bacteria,2GKSY@201174|Actinobacteria,4ES7X@85013|Frankiales	201174|Actinobacteria	K	RNA polymerase	sigF	GO:0000988,GO:0000990,GO:0003674,GO:0005488,GO:0005515,GO:0006355,GO:0006629,GO:0006950,GO:0006979,GO:0006995,GO:0007154,GO:0008150,GO:0008152,GO:0009266,GO:0009267,GO:0009409,GO:0009605,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0009991,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016987,GO:0019219,GO:0019222,GO:0019899,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0034059,GO:0036293,GO:0042221,GO:0042594,GO:0043175,GO:0043254,GO:0043562,GO:0044087,GO:0044238,GO:0045893,GO:0045935,GO:0046677,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0070063,GO:0070417,GO:0070482,GO:0071496,GO:0071704,GO:0080090,GO:0140110,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2000142,GO:2001141	-	ko:K03090	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r3,Sigma70_r4
HKD2_k127_9419333_4	656024.FsymDg_0979	6.647e-31	125.0	2EGA6@1|root,33A20@2|Bacteria,2IJG8@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9419333_0	1123320.KB889737_gene5367	3.687e-107	361.0	COG1597@1|root,COG1597@2|Bacteria,2GJ3K@201174|Actinobacteria	201174|Actinobacteria	I	Diacylglycerol kinase	-	-	-	-	-	-	-	-	-	-	-	-	DAGK_cat
HKD2_k127_9419333_1	298654.FraEuI1c_0805	1.032e-81	277.0	COG0584@1|root,COG0584@2|Bacteria,2I1MS@201174|Actinobacteria,4EWZP@85013|Frankiales	201174|Actinobacteria	C	PFAM Glycerophosphoryl diester phosphodiesterase	-	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD
HKD2_k127_9419333_3	298654.FraEuI1c_0804	6.938e-35	136.0	2DMIE@1|root,32RSG@2|Bacteria,2IQCG@201174|Actinobacteria,4ET35@85013|Frankiales	201174|Actinobacteria	K	Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA	whiB	-	-	ko:K18955	-	-	-	-	ko00000,ko03000	-	-	-	Whib
HKD2_k127_9445915_14	106370.Francci3_2058	5.682e-06	48.0	COG5433@1|root,COG5433@2|Bacteria,2HYBN@201174|Actinobacteria,4EWGM@85013|Frankiales	201174|Actinobacteria	L	required for the transposition of insertion element IS2404	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_assoc
HKD2_k127_9445915_8	298653.Franean1_6479	4.82e-36	142.0	COG1503@1|root,COG1503@2|Bacteria,2GSQM@201174|Actinobacteria,4EXIW@85013|Frankiales	201174|Actinobacteria	J	Protein of unknown function (DUF2795)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2795
HKD2_k127_9445915_0	222534.KB893711_gene5045	0.0	1603.0	COG2609@1|root,COG2609@2|Bacteria,2GJRE@201174|Actinobacteria,4ESAA@85013|Frankiales	201174|Actinobacteria	C	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	aceE	-	1.2.4.1	ko:K00163	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_N
HKD2_k127_9445915_6	656024.FsymDg_2523	3.452e-59	208.0	COG0432@1|root,COG0432@2|Bacteria,2IHWS@201174|Actinobacteria,4EVAT@85013|Frankiales	201174|Actinobacteria	S	Uncharacterised protein family UPF0047	-	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	UPF0047
HKD2_k127_9445915_4	222534.KB893711_gene5047	1.386e-68	235.0	2B57P@1|root,31Y1M@2|Bacteria,2IFRB@201174|Actinobacteria,4ESSE@85013|Frankiales	201174|Actinobacteria	S	Protein of unknown function (DUF3052)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3052
HKD2_k127_9445915_10	365528.KB891230_gene2059	7.72e-21	98.0	COG2161@1|root,COG2161@2|Bacteria,2IQ72@201174|Actinobacteria	201174|Actinobacteria	D	Antitoxin component of a toxin-antitoxin (TA) module	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
HKD2_k127_9445915_1	365528.KB891102_gene4590	4.78e-93	310.0	COG0740@1|root,COG0740@2|Bacteria,2GK5C@201174|Actinobacteria,4ES45@85013|Frankiales	201174|Actinobacteria	O	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins	clpP1	-	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	CLP_protease
HKD2_k127_9445915_5	298653.Franean1_1863	3.301e-63	223.0	2DUW4@1|root,32UXY@2|Bacteria,2IJWI@201174|Actinobacteria,4EWV4@85013|Frankiales	201174|Actinobacteria	S	Domain of unknown function (DUF4234)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4234
HKD2_k127_9445915_3	1380347.JNII01000008_gene4443	1.883e-72	256.0	2CK5M@1|root,33W5S@2|Bacteria,2IQNJ@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	MDMPI_N
HKD2_k127_9445915_2	106370.Francci3_3053	6.413e-80	268.0	COG1225@1|root,COG1225@2|Bacteria,2GKME@201174|Actinobacteria,4ESVF@85013|Frankiales	201174|Actinobacteria	O	PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	ahpE	GO:0003674,GO:0003824,GO:0004601,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0008150,GO:0008152,GO:0009605,GO:0009607,GO:0009636,GO:0009987,GO:0016209,GO:0016491,GO:0016684,GO:0020012,GO:0030682,GO:0042221,GO:0043207,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051409,GO:0051701,GO:0051704,GO:0051707,GO:0051716,GO:0051805,GO:0051807,GO:0051832,GO:0051834,GO:0051920,GO:0052060,GO:0052173,GO:0052200,GO:0052376,GO:0052551,GO:0052564,GO:0052565,GO:0052572,GO:0055114,GO:0070887,GO:0075136,GO:0097237,GO:0098754,GO:0098869,GO:1990748	1.11.1.15	ko:K03386	ko04214,map04214	-	-	-	ko00000,ko00001,ko01000,ko04147	-	-	-	AhpC-TSA
HKD2_k127_9445915_9	298653.Franean1_1865	4.9e-28	125.0	2E5NJ@1|root,330DC@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9445915_7	106370.Francci3_0027	8.36e-40	162.0	2B17N@1|root,31TN0@2|Bacteria,2GSPP@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9445915_13	1348663.KCH_76810	1.924e-06	54.0	COG0847@1|root,COG0847@2|Bacteria,2IRF3@201174|Actinobacteria,2M5AX@2063|Kitasatospora	201174|Actinobacteria	L	CRISPR-associated protein (Cas_Cas2CT1978)	-	-	-	ko:K09951	-	-	-	-	ko00000,ko02048	-	-	-	Cas_Cas2CT1978
HKD2_k127_9445915_11	1463887.KL590057_gene3663	1.297e-19	89.0	COG0847@1|root,COG0847@2|Bacteria,2IRF3@201174|Actinobacteria	201174|Actinobacteria	L	CRISPR-associated protein Cas2	-	-	-	ko:K09951	-	-	-	-	ko00000,ko02048	-	-	-	Cas_Cas2CT1978
HKD2_k127_9448708_2	326424.FRAAL1084	7.223e-62	213.0	COG0090@1|root,COG0090@2|Bacteria,2GK7R@201174|Actinobacteria,4ES62@85013|Frankiales	201174|Actinobacteria	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity	rplB	GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
HKD2_k127_9448708_4	298655.KI912266_gene321	1.211e-38	163.0	COG0089@1|root,COG0089@2|Bacteria,2IQ7V@201174|Actinobacteria,4ET1Y@85013|Frankiales	201174|Actinobacteria	J	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome	rplW	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02892	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L23
HKD2_k127_9448708_1	656024.FsymDg_3960	3.229e-93	322.0	COG0088@1|root,COG0088@2|Bacteria,2GJYJ@201174|Actinobacteria,4ES9Y@85013|Frankiales	201174|Actinobacteria	J	Forms part of the polypeptide exit tunnel	rplD	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0019538,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02926	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L4
HKD2_k127_9448708_0	656024.FsymDg_3961	2.346e-108	354.0	COG0087@1|root,COG0087@2|Bacteria,2GJXT@201174|Actinobacteria,4ERGJ@85013|Frankiales	201174|Actinobacteria	J	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rplC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	ko:K02906	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L3
HKD2_k127_9448708_3	222534.KB893739_gene1344	4.63e-58	207.0	COG0051@1|root,COG0051@2|Bacteria,2IHRA@201174|Actinobacteria,4ESVR@85013|Frankiales	201174|Actinobacteria	J	Involved in the binding of tRNA to the ribosomes	rpsJ	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02946	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S10
HKD2_k127_9448708_5	471852.Tcur_4323	7.671e-24	100.0	COG0050@1|root,COG0050@2|Bacteria,2GK4T@201174|Actinobacteria,4EFX7@85012|Streptosporangiales	201174|Actinobacteria	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
HKD2_k127_9456793_0	47763.JNZA01000010_gene5730	1.912e-73	261.0	COG3664@1|root,COG3664@2|Bacteria,2I92N@201174|Actinobacteria	201174|Actinobacteria	G	PFAM glycoside hydrolase family 39	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_39
HKD2_k127_9483155_7	1123023.JIAI01000002_gene4666	0.0009644	52.0	COG0654@1|root,COG0654@2|Bacteria,2I901@201174|Actinobacteria,4E5P8@85010|Pseudonocardiales	201174|Actinobacteria	CH	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_2,Trp_halogenase
HKD2_k127_9483155_3	1415779.JOMH01000001_gene2216	2.713e-80	277.0	COG0076@1|root,COG0076@2|Bacteria,1MWUX@1224|Proteobacteria,1RQ8G@1236|Gammaproteobacteria,1XC6I@135614|Xanthomonadales	135614|Xanthomonadales	E	Pyridoxal-dependent decarboxylase conserved domain	-	-	4.1.1.86	ko:K13745	ko00260,ko01120,map00260,map01120	-	R07650	RC00299	ko00000,ko00001,ko01000	-	-	-	Pyridoxal_deC
HKD2_k127_9483155_2	1464048.JNZS01000034_gene2641	1.436e-83	290.0	COG2890@1|root,COG2890@2|Bacteria,2GITA@201174|Actinobacteria,4DBD3@85008|Micromonosporales	201174|Actinobacteria	J	S-adenosyl methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_19
HKD2_k127_9483155_5	1227484.C471_02470	8.739e-13	80.0	COG0693@1|root,arCOG00769@2157|Archaea,2XV38@28890|Euryarchaeota,23RWT@183963|Halobacteria	183963|Halobacteria	S	intracellular protease amidase	araC	-	-	-	-	-	-	-	-	-	-	-	DJ-1_PfpI
HKD2_k127_9483155_0	216594.MMAR_4002	6.689e-95	322.0	COG1028@1|root,COG1028@2|Bacteria,2I32I@201174|Actinobacteria,23FAN@1762|Mycobacteriaceae	201174|Actinobacteria	IQ	Fungal family of unknown function (DUF1776)	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HKD2_k127_9483155_1	47763.JNZA01000035_gene2560	2.905e-88	307.0	COG0262@1|root,COG0262@2|Bacteria,2GKX0@201174|Actinobacteria	201174|Actinobacteria	H	bifunctional deaminase-reductase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	RibD_C
HKD2_k127_9483155_4	266940.Krad_2515	3.455e-37	148.0	COG1787@1|root,COG1787@2|Bacteria	2|Bacteria	V	Restriction endonuclease	-	-	-	ko:K07448	-	-	-	-	ko00000,ko02048	-	-	-	Mrr_cat
HKD2_k127_954422_12	298653.Franean1_4903	1.328e-90	299.0	COG0624@1|root,COG0624@2|Bacteria,2GKKW@201174|Actinobacteria,4ERTJ@85013|Frankiales	201174|Actinobacteria	E	PFAM Peptidase M20	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
HKD2_k127_954422_14	298655.KI912266_gene3680	1.352e-27	117.0	2EGVE@1|root,33AMN@2|Bacteria,2I1EU@201174|Actinobacteria,4EWM0@85013|Frankiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_954422_8	656024.FsymDg_2263	3.17e-105	375.0	COG5542@1|root,COG5542@2|Bacteria	2|Bacteria	O	integral membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	Mannosyl_trans2
HKD2_k127_954422_3	656024.FsymDg_2264	2.578e-196	632.0	COG5305@1|root,COG5305@2|Bacteria,2HTG8@201174|Actinobacteria,4ESH8@85013|Frankiales	201174|Actinobacteria	S	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HKD2_k127_954422_0	656024.FsymDg_2265	1.311e-276	859.0	COG1232@1|root,COG1232@2|Bacteria,2IDI5@201174|Actinobacteria,4ETUQ@85013|Frankiales	201174|Actinobacteria	H	PFAM amine oxidase	-	-	5.4.99.9	ko:K01854	ko00052,ko00520,map00052,map00520	-	R00505,R09009	RC00317,RC02396	ko00000,ko00001,ko01000	-	-	-	Amino_oxidase
HKD2_k127_954422_9	298654.FraEuI1c_3769	3.394e-105	381.0	2B0YS@1|root,31TBU@2|Bacteria,2GPJZ@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	GT87
HKD2_k127_954422_2	656024.FsymDg_2267	3.07e-224	713.0	COG5305@1|root,COG5305@2|Bacteria,2HTG8@201174|Actinobacteria,4ESH8@85013|Frankiales	201174|Actinobacteria	S	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HKD2_k127_954422_1	656024.FsymDg_2268	1.892e-233	737.0	COG0507@1|root,COG0507@2|Bacteria,2GIX1@201174|Actinobacteria,4ES43@85013|Frankiales	201174|Actinobacteria	L	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	3.1.11.5	ko:K01144,ko:K03581	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AAA_30,HHH_4,UvrD_C_2
HKD2_k127_954422_7	1211815.CBYP010000060_gene3123	6.843e-128	417.0	COG0667@1|root,COG0667@2|Bacteria,2GMNA@201174|Actinobacteria,4ERJH@85013|Frankiales	201174|Actinobacteria	C	aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
HKD2_k127_954422_4	1463825.JNXC01000012_gene1896	1.054e-155	498.0	COG2141@1|root,COG2141@2|Bacteria,2GIY3@201174|Actinobacteria,4DXE3@85010|Pseudonocardiales	201174|Actinobacteria	C	PFAM Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
HKD2_k127_954422_6	656024.FsymDg_2269	1.033e-131	426.0	COG1968@1|root,COG1968@2|Bacteria,2GJVG@201174|Actinobacteria	201174|Actinobacteria	V	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin	uppP	GO:0006950,GO:0008150,GO:0050896,GO:0051409	3.6.1.27	ko:K06153	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	BacA
HKD2_k127_954422_11	298654.FraEuI1c_3765	2.372e-93	325.0	COG0406@1|root,COG0406@2|Bacteria,2GK8N@201174|Actinobacteria,4ESCE@85013|Frankiales	201174|Actinobacteria	G	phosphoglycerate mutase	-	-	5.4.2.11	ko:K01834	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	His_Phos_1
HKD2_k127_954422_13	1380347.JNII01000005_gene3004	1.562e-60	218.0	298YA@1|root,2ZW25@2|Bacteria,2GIYI@201174|Actinobacteria,4ESX0@85013|Frankiales	201174|Actinobacteria	S	Evidence 4 Homologs of previously reported genes of	-	-	-	-	-	-	-	-	-	-	-	-	DUF3090
HKD2_k127_954422_16	1121378.KB899742_gene3648	1.187e-08	58.0	COG4374@1|root,COG4374@2|Bacteria,1WK8Z@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
HKD2_k127_954422_17	261292.Nit79A3_2484	1.828e-08	66.0	COG4374@1|root,COG4374@2|Bacteria,1Q1CR@1224|Proteobacteria,2W6I6@28216|Betaproteobacteria	28216|Betaproteobacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
HKD2_k127_954422_15	675635.Psed_6494	1.809e-15	79.0	COG2002@1|root,COG2002@2|Bacteria,2HB3J@201174|Actinobacteria	201174|Actinobacteria	K	toxin-antitoxin pair type II binding	-	-	-	-	-	-	-	-	-	-	-	-	MazE_antitoxin
HKD2_k127_954422_10	479432.Sros_5932	8.435e-105	346.0	COG5032@1|root,COG5032@2|Bacteria,2GME7@201174|Actinobacteria,4EGYT@85012|Streptosporangiales	201174|Actinobacteria	BDLTU	Phosphatidylinositol	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_954422_5	106370.Francci3_2642	1.956e-150	490.0	COG0215@1|root,COG0215@2|Bacteria,2GJZR@201174|Actinobacteria,4ERJJ@85013|Frankiales	201174|Actinobacteria	J	Catalyzes the ATP-dependent condensation of GlcN-Ins and L-cysteine to form L-Cys-GlcN-Ins	mshC	GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010125,GO:0010126,GO:0010467,GO:0016020,GO:0016070,GO:0016137,GO:0016138,GO:0016874,GO:0016875,GO:0016879,GO:0016880,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035446,GO:0035639,GO:0036094,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044272,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	6.1.1.16,6.3.1.13	ko:K01883,ko:K15526	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iNJ661.Rv2130c	tRNA-synt_1e
HKD2_k127_9579345_7	1171373.PACID_03410	0.0002496	43.0	COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,2IAHV@201174|Actinobacteria,4DUEP@85009|Propionibacteriales	201174|Actinobacteria	L	Winged helix-turn helix	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_28,HTH_32,HTH_33
HKD2_k127_9579345_2	1463920.JOGB01000003_gene2717	8.67e-53	208.0	COG1944@1|root,COG1944@2|Bacteria	2|Bacteria	S	ATP diphosphatase activity	-	-	-	ko:K09136	-	-	-	-	ko00000,ko03009	-	-	-	YcaO
HKD2_k127_9579345_0	1463920.JOGB01000003_gene2718	6.413e-149	506.0	COG4076@1|root,COG4076@2|Bacteria,2IA0E@201174|Actinobacteria	201174|Actinobacteria	S	Ribosomal protein L11 methyltransferase (PrmA)	-	-	2.1.1.319,2.1.1.320	ko:K11434,ko:K19737,ko:K21170	ko01059,ko01130,ko04068,ko04922,map01059,map01130,map04068,map04922	M00825	R11216,R11217,R11218,R11219,R11220	RC00003,RC02120,RC03388,RC03389,RC03390,RC03391	ko00000,ko00001,ko00002,ko01000,ko03036	-	-	-	Methyltransf_25,PRMT5_C,PrmA
HKD2_k127_9579345_3	570268.ANBB01000061_gene947	3.09e-51	189.0	COG0452@1|root,COG0452@2|Bacteria	2|Bacteria	H	phosphopantothenoylcysteine decarboxylase activity	-	-	4.1.1.36,6.3.2.5	ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	Ank_4,Flavoprotein,GGACT,Phytochelatin
HKD2_k127_9579345_5	1463920.JOGB01000003_gene2720	2.357e-27	126.0	2BSQT@1|root,32MTM@2|Bacteria,2HE04@201174|Actinobacteria	201174|Actinobacteria	S	Phosphotransferase enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	APH
HKD2_k127_9579345_1	1463920.JOGB01000003_gene2721	2.463e-77	287.0	COG4403@1|root,COG4403@2|Bacteria	2|Bacteria	V	Lanthionine synthetase C family protein	-	-	-	-	-	-	-	-	-	-	-	-	VCBS
HKD2_k127_9579345_4	570268.ANBB01000061_gene941	2.183e-46	185.0	COG3173@1|root,COG3173@2|Bacteria	2|Bacteria	S	very-long-chain-acyl-CoA dehydrogenase activity	-	-	2.7.1.4	ko:K00847	ko00051,ko00500,ko00520,ko01100,map00051,map00500,map00520,map01100	-	R00760,R00867,R03920	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	APH
HKD2_k127_9579345_6	1463920.JOGB01000003_gene2723	4.804e-20	96.0	2BSWH@1|root,32N05@2|Bacteria,2HEDS@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9585922_1	1211815.CBYP010000036_gene2256	3.45e-152	490.0	COG0172@1|root,COG0172@2|Bacteria,2GIWP@201174|Actinobacteria,4EREN@85013|Frankiales	201174|Actinobacteria	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Seryl_tRNA_N,tRNA-synt_2b
HKD2_k127_9585922_6	1896.JOAU01000004_gene80	6.344e-47	186.0	COG0671@1|root,COG0671@2|Bacteria,2I9FB@201174|Actinobacteria	201174|Actinobacteria	I	Phosphoesterase, PA-phosphatase related	-	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2
HKD2_k127_9585922_3	656024.FsymDg_0229	2.995e-121	398.0	COG0077@1|root,COG0077@2|Bacteria,2GJQ5@201174|Actinobacteria,4ESN5@85013|Frankiales	201174|Actinobacteria	E	Prephenate dehydratase	pheA	-	4.2.1.51	ko:K04518	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024	R00691,R01373	RC00360	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,PDT
HKD2_k127_9585922_4	298653.Franean1_0164	1.427e-98	341.0	COG1691@1|root,COG1691@2|Bacteria,2IAKU@201174|Actinobacteria,4EU7Y@85013|Frankiales	201174|Actinobacteria	S	(AIR) carboxylase	-	-	-	ko:K06898	-	-	-	-	ko00000	-	-	-	AIRC
HKD2_k127_9585922_2	656024.FsymDg_0143	1.279e-126	431.0	COG1641@1|root,COG1641@2|Bacteria,2I8J1@201174|Actinobacteria	201174|Actinobacteria	S	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes	larC	-	4.99.1.12	ko:K09121	-	-	-	-	ko00000,ko01000	-	-	-	DUF111
HKD2_k127_9585922_5	526225.Gobs_4690	2.722e-85	294.0	COG3861@1|root,COG3861@2|Bacteria,2II0U@201174|Actinobacteria,4EV5Z@85013|Frankiales	201174|Actinobacteria	S	Evidence 4 Homologs of previously reported genes of	-	-	-	-	-	-	-	-	-	-	-	-	DUF2382,PRC
HKD2_k127_9585922_7	1134474.O59_002864	1.377e-29	132.0	COG2718@1|root,COG2718@2|Bacteria,1MVXE@1224|Proteobacteria,1S1V1@1236|Gammaproteobacteria,1FHZ8@10|Cellvibrio	1236|Gammaproteobacteria	S	Iron-containing redox enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Haem_oxygenas_2
HKD2_k127_9585922_0	390989.JOEG01000004_gene4094	3.196e-154	511.0	COG2235@1|root,COG2235@2|Bacteria,2GJTR@201174|Actinobacteria,4D8RS@85008|Micromonosporales	201174|Actinobacteria	E	Arginine	arcA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	3.5.3.6	ko:K01478	ko00220,ko01100,ko01110,ko01130,map00220,map01100,map01110,map01130	-	R00552	RC00177	ko00000,ko00001,ko01000	-	-	-	Amidinotransf
HKD2_k127_9710458_1	298653.Franean1_0162	1.215e-144	468.0	COG0644@1|root,COG0644@2|Bacteria,2GMH9@201174|Actinobacteria	201174|Actinobacteria	C	geranylgeranyl reductase	fixC	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3
HKD2_k127_9710458_0	656024.FsymDg_0705	3.027e-260	822.0	COG2409@1|root,COG2409@2|Bacteria,2GJ5A@201174|Actinobacteria,4ESAG@85013|Frankiales	201174|Actinobacteria	S	MMPL family	-	-	-	ko:K06994	-	-	-	-	ko00000	-	-	-	MMPL
HKD2_k127_9710458_2	222534.KB893670_gene3925	1.298e-64	229.0	COG1309@1|root,COG1309@2|Bacteria,2GMCG@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
HKD2_k127_9710458_3	1968.JOEV01000013_gene869	1.046e-28	120.0	2E7W4@1|root,332AV@2|Bacteria,2IMEE@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9712679_7	465515.Mlut_01530	0.0002792	51.0	2C4MW@1|root,32RKK@2|Bacteria,2IQ6A@201174|Actinobacteria,1W9ZQ@1268|Micrococcaceae	201174|Actinobacteria	S	Lsr2	lsr	-	-	-	-	-	-	-	-	-	-	-	Lsr2
HKD2_k127_9712679_6	405948.SACE_0674	1.096e-08	65.0	2DNFT@1|root,32XAD@2|Bacteria,2IKQA@201174|Actinobacteria,4E69N@85010|Pseudonocardiales	201174|Actinobacteria	S	Protein of unknown function (DUF4232)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4232
HKD2_k127_9712679_4	1122997.AUDD01000009_gene227	2.618e-14	78.0	COG3382@1|root,COG3382@2|Bacteria,2GMX2@201174|Actinobacteria	201174|Actinobacteria	S	B3 4 domain	-	-	-	-	-	-	-	-	-	-	-	-	B3_4
HKD2_k127_9712679_2	653386.HMPREF0975_02353	2.087e-38	151.0	COG3832@1|root,COG3832@2|Bacteria,2GSCI@201174|Actinobacteria,4D5JH@85005|Actinomycetales	201174|Actinobacteria	S	the current gene model (or a revised gene model) may contain a frame shift	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
HKD2_k127_9712679_3	298654.FraEuI1c_0867	3.252e-24	105.0	COG0640@1|root,COG0640@2|Bacteria,2IT9E@201174|Actinobacteria	201174|Actinobacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
HKD2_k127_9712679_5	1449069.JMLO01000032_gene806	1.817e-09	64.0	2EMTZ@1|root,33FGB@2|Bacteria,2GUCW@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	TfoX_N
HKD2_k127_9712679_1	1463934.JOCF01000007_gene1381	3.666e-39	154.0	COG3631@1|root,COG3631@2|Bacteria,2IRVV@201174|Actinobacteria	201174|Actinobacteria	S	Ketosteroid isomerase-related protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9712679_0	33898.JRHJ01000049_gene7703	1.481e-39	151.0	COG1131@1|root,COG1131@2|Bacteria,2GIY8@201174|Actinobacteria	201174|Actinobacteria	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
HKD2_k127_9715441_7	298654.FraEuI1c_2313	1.565e-14	72.0	2ATJW@1|root,3361K@2|Bacteria,2I80Y@201174|Actinobacteria	201174|Actinobacteria	S	Domain of unknown function (DUF4193)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4193
HKD2_k127_9715441_2	1206744.BAGL01000027_gene7337	1.718e-64	228.0	COG1335@1|root,COG1335@2|Bacteria,2IFQW@201174|Actinobacteria,4FUW7@85025|Nocardiaceae	201174|Actinobacteria	Q	Isochorismatase family	pncA	GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006766,GO:0006767,GO:0006769,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0008936,GO:0009820,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0017144,GO:0030145,GO:0034641,GO:0043167,GO:0043169,GO:0043603,GO:0044237,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0071704,GO:0072524,GO:1901360,GO:1901564	3.5.1.19	ko:K08281	ko00760,ko01100,map00760,map01100	-	R01268	RC00100	ko00000,ko00001,ko01000	-	-	-	Isochorismatase
HKD2_k127_9715441_0	298654.FraEuI1c_2262	2.155e-121	403.0	COG1814@1|root,COG1814@2|Bacteria,2GIZ3@201174|Actinobacteria,4ESQ1@85013|Frankiales	201174|Actinobacteria	S	VIT family	-	-	-	-	-	-	-	-	-	-	-	-	VIT1
HKD2_k127_9715441_3	1146883.BLASA_2202	9.916e-61	220.0	COG4759@1|root,COG4759@2|Bacteria,2GRSQ@201174|Actinobacteria,4ESKP@85013|Frankiales	201174|Actinobacteria	O	Sucrase/ferredoxin-like	-	-	-	-	-	-	-	-	-	-	-	-	Suc_Fer-like
HKD2_k127_9715441_1	266940.Krad_1339	4.339e-109	369.0	COG2850@1|root,COG2850@2|Bacteria,2GMR2@201174|Actinobacteria	201174|Actinobacteria	O	Cupin 4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_4
HKD2_k127_9715441_5	1449353.JQMQ01000005_gene628	4.857e-32	136.0	COG0239@1|root,COG0239@2|Bacteria,2IKM1@201174|Actinobacteria,2NIHG@228398|Streptacidiphilus	201174|Actinobacteria	D	CrcB-like protein, Camphor Resistance (CrcB)	crcB1	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661,GO:1903424,GO:1903425	-	ko:K06199	-	-	-	-	ko00000,ko02000	1.A.43.1,1.A.43.2,1.A.43.3	-	-	CRCB
HKD2_k127_9715441_4	1463901.JOIY01000009_gene2779	2.843e-41	156.0	COG1993@1|root,COG1993@2|Bacteria,2IM7J@201174|Actinobacteria	201174|Actinobacteria	S	Uncharacterized ACR, COG1993	-	-	-	ko:K09137	-	-	-	-	ko00000	-	-	-	DUF190
HKD2_k127_9715441_6	1380393.JHVP01000001_gene2258	2.462e-25	120.0	COG0239@1|root,COG0239@2|Bacteria,2IKWG@201174|Actinobacteria,4ETME@85013|Frankiales	201174|Actinobacteria	D	Important for reducing fluoride concentration in the cell, thus reducing its toxicity	crcB	-	-	ko:K06199	-	-	-	-	ko00000,ko02000	1.A.43.1,1.A.43.2,1.A.43.3	-	-	CRCB
HKD2_k127_9720546_7	526225.Gobs_4944	1.178e-148	482.0	COG1454@1|root,COG1454@2|Bacteria,2I2FD@201174|Actinobacteria,4EUKA@85013|Frankiales	201174|Actinobacteria	C	PFAM Iron-containing alcohol dehydrogenase	-	-	1.1.1.1,1.1.1.202	ko:K00086,ko:K11440	ko00260,ko00561,ko00640,ko01100,map00260,map00561,map00640,map01100	M00555	R02377,R03119,R08557,R08558	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	Fe-ADH
HKD2_k127_9720546_10	1068978.AMETH_5571	4.982e-82	289.0	COG4585@1|root,COG4585@2|Bacteria,2I8I8@201174|Actinobacteria,4E17E@85010|Pseudonocardiales	201174|Actinobacteria	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
HKD2_k127_9720546_11	1120948.KB903224_gene319	3.521e-76	280.0	COG2197@1|root,COG2197@2|Bacteria,2GWFB@201174|Actinobacteria,4E35J@85010|Pseudonocardiales	201174|Actinobacteria	KT	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HKD2_k127_9720546_1	1078020.KEK_15563	6.19e-285	887.0	COG1012@1|root,COG1012@2|Bacteria,2GIWZ@201174|Actinobacteria,234Y9@1762|Mycobacteriaceae	201174|Actinobacteria	C	Belongs to the aldehyde dehydrogenase family	aldA	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0009605,GO:0009607,GO:0016020,GO:0035821,GO:0043207,GO:0044003,GO:0044403,GO:0044419,GO:0044464,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0052031,GO:0052173,GO:0052200,GO:0052255,GO:0052552,GO:0052553,GO:0052561,GO:0052562,GO:0052564,GO:0052572,GO:0071944,GO:0075136	-	ko:K00138,ko:K18370	ko00010,ko00620,ko00640,ko01100,ko01110,ko01120,map00010,map00620,map00640,map01100,map01110,map01120	-	R00711,R10703	RC00047,RC00545	ko00000,ko00001,ko01000	-	-	-	Aldedh
HKD2_k127_9720546_14	189753.AXAS01000016_gene1394	2.802e-56	204.0	COG3564@1|root,COG3564@2|Bacteria,1RGYH@1224|Proteobacteria,2U9NU@28211|Alphaproteobacteria,3JYT2@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF779)	-	-	-	ko:K09959	-	-	-	-	ko00000	-	-	-	DUF779
HKD2_k127_9720546_13	42256.RradSPS_2632	2.825e-60	239.0	COG0500@1|root,COG2226@2|Bacteria,2GMZW@201174|Actinobacteria	201174|Actinobacteria	Q	Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
HKD2_k127_9720546_6	42256.RradSPS_2631	1.928e-167	540.0	COG3552@1|root,COG3552@2|Bacteria,2GNTS@201174|Actinobacteria,4CPGF@84995|Rubrobacteria	84995|Rubrobacteria	S	VWA domain containing CoxE-like protein	-	-	-	ko:K07161	-	-	-	-	ko00000	-	-	-	VWA_CoxE
HKD2_k127_9720546_8	350058.Mvan_5478	3.238e-143	462.0	COG0714@1|root,COG0714@2|Bacteria,2GMM2@201174|Actinobacteria,235SB@1762|Mycobacteriaceae	201174|Actinobacteria	O	AAA domain (dynein-related subfamily)	-	-	-	-	-	-	-	-	-	-	-	-	AAA,AAA_5
HKD2_k127_9720546_2	42256.RradSPS_2629	7.372e-235	732.0	COG1454@1|root,COG1454@2|Bacteria,2I2FD@201174|Actinobacteria,4CQA4@84995|Rubrobacteria	201174|Actinobacteria	C	COG COG1454 Alcohol dehydrogenase class IV Energy production and conversion	fucO	-	1.1.1.77,1.1.99.37,1.2.98.1	ko:K00048,ko:K17067	ko00625,ko00630,ko00640,ko00680,ko01120,ko01200,map00625,map00630,map00640,map00680,map01120,map01200	-	R00614,R01781,R02257	RC00034,RC00087,RC00099,RC00188	ko00000,ko00001,ko01000	-	-	-	Fe-ADH
HKD2_k127_9720546_4	1123023.JIAI01000008_gene1332	2.457e-174	553.0	COG0535@1|root,COG0535@2|Bacteria,2GNSY@201174|Actinobacteria,4DZNS@85010|Pseudonocardiales	201174|Actinobacteria	C	Radical SAM	pqqE	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM,SPASM
HKD2_k127_9720546_3	1229780.BN381_250080	9.682e-204	671.0	COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,2GK8E@201174|Actinobacteria,3UWJK@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	C	NADH:flavin oxidoreductase / NADH oxidase family	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_FMN,Pyr_redox_2
HKD2_k127_9720546_0	1229780.BN381_250079	1.683e-310	963.0	COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,2GK8E@201174|Actinobacteria,3UWJK@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	C	NADH:flavin oxidoreductase / NADH oxidase family	-	-	1.3.1.34	ko:K00219	-	-	-	-	ko00000,ko01000	-	-	-	FAD_oxidored,Oxidored_FMN,Pyr_redox_2
HKD2_k127_9720546_12	882083.SacmaDRAFT_1199	8.974e-76	289.0	COG2025@1|root,COG2025@2|Bacteria,2IIKX@201174|Actinobacteria	201174|Actinobacteria	C	Electron transfer flavoprotein alpha subunit	-	-	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	-	ETF,ETF_alpha
HKD2_k127_9720546_5	1157638.KB892174_gene326	4.503e-174	591.0	COG0644@1|root,COG0644@2|Bacteria	2|Bacteria	C	geranylgeranyl reductase activity	-	-	-	ko:K00313	-	-	-	-	ko00000,ko01000	-	-	-	DAO,FAD_binding_3,FAD_oxidored,Pyr_redox_2
HKD2_k127_9720546_16	656024.FsymDg_2651	2.203e-41	171.0	COG2440@1|root,COG2440@2|Bacteria	2|Bacteria	C	oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor	fixX	-	-	ko:K03855	-	-	-	-	ko00000	-	-	-	ETF_QO,Fer4_9
HKD2_k127_9720546_17	345341.KUTG_07787	5.601e-36	151.0	COG2086@1|root,COG2086@2|Bacteria,2GSWB@201174|Actinobacteria	201174|Actinobacteria	C	Electron transfer flavoprotein	-	-	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
HKD2_k127_9720546_9	1278073.MYSTI_00522	5.275e-83	291.0	COG0451@1|root,COG0451@2|Bacteria,1RBSM@1224|Proteobacteria,42XUG@68525|delta/epsilon subdivisions,2WTSY@28221|Deltaproteobacteria,2YX8Q@29|Myxococcales	28221|Deltaproteobacteria	GM	NAD dependent epimerase/dehydratase family	-	-	1.3.1.45	ko:K05281	ko00943,ko01110,map00943,map01110	-	R06562,R06563,R07747,R07751	RC00805	ko00000,ko00001,ko01000	-	-	-	Epimerase
HKD2_k127_9720546_18	656024.FsymDg_3985	5.249e-16	92.0	COG0461@1|root,COG0461@2|Bacteria,2GKUQ@201174|Actinobacteria	201174|Actinobacteria	F	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)	pyrE	-	2.4.2.10	ko:K00762	ko00240,ko01100,map00240,map01100	M00051	R01870	RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran
HKD2_k127_9720546_15	710111.FraQA3DRAFT_3305	1.75e-55	200.0	COG1403@1|root,COG2310@1|root,COG1403@2|Bacteria,COG2310@2|Bacteria,2GK6H@201174|Actinobacteria,4EW0X@85013|Frankiales	201174|Actinobacteria	TV	Stress protein	-	-	-	ko:K05792	-	-	-	-	ko00000	-	-	-	DUF2510,HNH,TerD
HKD2_k127_9731933_1	446470.Snas_6167	7.708e-134	439.0	COG2124@1|root,COG2124@2|Bacteria,2GJ8V@201174|Actinobacteria	201174|Actinobacteria	Q	cytochrome p450	-	-	-	-	-	-	-	-	-	-	-	-	p450
HKD2_k127_9731933_0	2074.JNYD01000003_gene3394	4.526e-157	530.0	COG2909@1|root,COG2909@2|Bacteria,2GJAR@201174|Actinobacteria,4E16G@85010|Pseudonocardiales	201174|Actinobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GerE
HKD2_k127_9731933_2	2074.JNYD01000003_gene3395	2.967e-13	76.0	COG2909@1|root,COG2909@2|Bacteria,2GJAR@201174|Actinobacteria,4E16G@85010|Pseudonocardiales	201174|Actinobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GerE
HKD2_k127_978306_4	1415166.NONO_c49740	1.096e-07	60.0	COG1993@1|root,COG1993@2|Bacteria,2IM7J@201174|Actinobacteria,4G1XZ@85025|Nocardiaceae	201174|Actinobacteria	S	Uncharacterized ACR, COG1993	-	-	-	ko:K09137	-	-	-	-	ko00000	-	-	-	DUF190
HKD2_k127_978306_0	44060.JODL01000004_gene2663	5.153e-56	201.0	COG2259@1|root,COG2259@2|Bacteria,2IQ5C@201174|Actinobacteria	201174|Actinobacteria	S	DoxX family	-	-	-	ko:K15977	-	-	-	-	ko00000	-	-	-	DoxX
HKD2_k127_978306_3	1206725.BAFU01000033_gene2811	7.205e-09	68.0	2A0CG@1|root,30NG0@2|Bacteria,2I0JE@201174|Actinobacteria,4G80D@85025|Nocardiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_978306_2	479433.Caci_6678	4.988e-30	137.0	COG0477@1|root,COG0477@2|Bacteria,2GIUM@201174|Actinobacteria	201174|Actinobacteria	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD2_k127_978306_5	710687.KI912270_gene4527	7.373e-06	57.0	COG2770@1|root,COG5002@1|root,COG2770@2|Bacteria,COG5002@2|Bacteria,2I2WW@201174|Actinobacteria,23FHB@1762|Mycobacteriaceae	201174|Actinobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
HKD2_k127_978306_1	1089544.KB912942_gene2635	2.288e-42	176.0	COG1917@1|root,COG1917@2|Bacteria,2IQ74@201174|Actinobacteria,4ECDH@85010|Pseudonocardiales	201174|Actinobacteria	S	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_978334_1	562970.Btus_1231	2.334e-63	226.0	COG2267@1|root,COG2267@2|Bacteria	2|Bacteria	I	carboxylic ester hydrolase activity	-	-	1.11.1.10	ko:K00433	-	-	-	-	ko00000,ko01000	-	-	-	Abhydrolase_1,Abhydrolase_6
HKD2_k127_978334_0	656024.FsymDg_1098	3.322e-130	426.0	COG1300@1|root,COG1300@2|Bacteria,2GJTG@201174|Actinobacteria	201174|Actinobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	SpoIIM
HKD2_k127_978334_2	298653.Franean1_5849	0.0001658	50.0	COG1714@1|root,COG1714@2|Bacteria,2H4MP@201174|Actinobacteria,4EVDV@85013|Frankiales	201174|Actinobacteria	S	RDD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	RDD
HKD2_k127_9807802_0	1048339.KB913029_gene2528	2.165e-255	809.0	COG3127@1|root,COG3127@2|Bacteria,2H37M@201174|Actinobacteria,4ERZ6@85013|Frankiales	201174|Actinobacteria	Q	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HKD2_k127_9807802_2	1463926.JOCA01000004_gene5095	2.6e-94	325.0	COG1136@1|root,COG1136@2|Bacteria,2GJN6@201174|Actinobacteria	201174|Actinobacteria	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD2_k127_9807802_1	1906.SFRA_27300	1.271e-112	380.0	COG1653@1|root,COG1653@2|Bacteria,2GJXB@201174|Actinobacteria	201174|Actinobacteria	G	ABC transporter substrate-binding protein	-	-	-	ko:K02027,ko:K10232	ko02010,map02010	M00201,M00207	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.32,3.A.1.1.8	-	-	SBP_bac_1,SBP_bac_8
HKD2_k127_9807802_3	1211815.CBYP010000050_gene561	8.005e-60	217.0	COG1732@1|root,COG1732@2|Bacteria,2GJWY@201174|Actinobacteria,4EVAF@85013|Frankiales	201174|Actinobacteria	M	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	ko:K05845	ko02010,map02010	M00209	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	OpuAC
HKD2_k127_9810825_5	367299.JOEE01000005_gene3472	1.509e-76	266.0	COG0543@1|root,COG0543@2|Bacteria,2HQ24@201174|Actinobacteria,4FFS3@85021|Intrasporangiaceae	201174|Actinobacteria	C	Dihydroorotate oxidase	pyrK	-	-	ko:K02823	ko00240,ko01100,map00240,map01100	-	-	-	ko00000,ko00001	-	-	-	DHODB_Fe-S_bind,FAD_binding_6,NAD_binding_1
HKD2_k127_9810825_2	351607.Acel_1296	4.485e-128	432.0	COG0167@1|root,COG0167@2|Bacteria,2GKC6@201174|Actinobacteria,4ERIP@85013|Frankiales	201174|Actinobacteria	F	Catalyzes the conversion of dihydroorotate to orotate	pyrD	-	1.3.1.14,1.3.5.2	ko:K00254,ko:K17828	ko00240,ko01100,map00240,map01100	M00051	R01868,R01869	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
HKD2_k127_9810825_4	471852.Tcur_3009	8.753e-94	315.0	COG0284@1|root,COG0284@2|Bacteria,2HPEA@201174|Actinobacteria,4EHE6@85012|Streptosporangiales	201174|Actinobacteria	F	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)	pyrF	-	4.1.1.23	ko:K01591	ko00240,ko01100,map00240,map01100	M00051	R00965	RC00409	ko00000,ko00001,ko00002,ko01000	-	-	-	OMPdecase
HKD2_k127_9810825_8	710111.FraQA3DRAFT_6304	7.174e-42	158.0	COG0099@1|root,COG0099@2|Bacteria,2IKPU@201174|Actinobacteria,4ESZ8@85013|Frankiales	201174|Actinobacteria	J	Helix-hairpin-helix DNA-binding motif class 1	mihF	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9810825_6	656024.FsymDg_3312	2.96e-76	281.0	COG0194@1|root,COG0194@2|Bacteria,2GK2M@201174|Actinobacteria,4ESP1@85013|Frankiales	201174|Actinobacteria	F	Essential for recycling GMP and indirectly, cGMP	gmk	GO:0003674,GO:0003824,GO:0004385,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009150,GO:0009161,GO:0009165,GO:0009167,GO:0009179,GO:0009185,GO:0009259,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0042278,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046483,GO:0046710,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901657	2.7.4.8	ko:K00942	ko00230,ko01100,map00230,map01100	M00050	R00332,R02090	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_kin
HKD2_k127_9810825_7	106370.Francci3_3194	3.24e-43	171.0	COG1758@1|root,COG1758@2|Bacteria,2IQHU@201174|Actinobacteria,4ET5S@85013|Frankiales	201174|Actinobacteria	K	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits	rpoZ	GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030312,GO:0040007,GO:0044464,GO:0071944	2.7.7.6	ko:K03060	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb6
HKD2_k127_9810825_1	656024.FsymDg_3310	1.761e-174	555.0	COG0452@1|root,COG0452@2|Bacteria,2GJGJ@201174|Actinobacteria,4ERES@85013|Frankiales	201174|Actinobacteria	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	coaBC	GO:0003674,GO:0003824,GO:0004633,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016020,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044464,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.1.36,6.3.2.5	ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	DFP,Flavoprotein
HKD2_k127_9810825_0	656024.FsymDg_3309	9.158e-226	707.0	COG0192@1|root,COG0192@2|Bacteria,2GJ4U@201174|Actinobacteria,4ES7S@85013|Frankiales	201174|Actinobacteria	H	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme	metK	GO:0003674,GO:0003824,GO:0004478,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0016740,GO:0016765,GO:0019899,GO:0030312,GO:0035375,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
HKD2_k127_9810825_3	1120936.KB907210_gene5770	2.145e-106	353.0	COG1198@1|root,COG1198@2|Bacteria,2GKES@201174|Actinobacteria,4EHCM@85012|Streptosporangiales	201174|Actinobacteria	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006270,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0042623,GO:0043138,GO:0043140,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140097,GO:1901360,GO:1901576	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	-
HKD2_k127_981135_6	414996.IL38_19380	1.16e-25	106.0	2DMIE@1|root,32RSG@2|Bacteria,2IQCG@201174|Actinobacteria,40A9Z@622450|Actinopolysporales	201174|Actinobacteria	K	Transcription factor WhiB	whiB	GO:0000302,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009892,GO:0010035,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0015035,GO:0015036,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0042221,GO:0042493,GO:0045892,GO:0045934,GO:0047134,GO:0048037,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0060255,GO:0065007,GO:0071731,GO:0080090,GO:0097159,GO:0097366,GO:1901363,GO:1901698,GO:1901700,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141	-	ko:K18955	-	-	-	-	ko00000,ko03000	-	-	-	Whib
HKD2_k127_981135_0	298653.Franean1_0970	2.07e-219	690.0	COG3920@1|root,COG3920@2|Bacteria,2GKMP@201174|Actinobacteria,4ES2M@85013|Frankiales	201174|Actinobacteria	T	histidine kinase, dimerisation phosphoacceptor	pdtaS	GO:0000155,GO:0000160,GO:0000166,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0005488,GO:0005524,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0017076,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035556,GO:0035639,GO:0036094,GO:0036211,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564	2.7.13.3	ko:K00936	-	M00839	-	-	ko00000,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,H_kinase_N,HisKA_2,PAS_4
HKD2_k127_981135_1	446470.Snas_0470	1.542e-165	535.0	COG0161@1|root,COG0161@2|Bacteria,2I2DN@201174|Actinobacteria,4EY5T@85014|Glycomycetales	201174|Actinobacteria	H	Aminotransferase class-III	-	-	2.6.1.62	ko:K00833	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03231	RC00006,RC00887	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
HKD2_k127_981135_2	298654.FraEuI1c_0802	3.467e-151	496.0	COG0156@1|root,COG0156@2|Bacteria,2GISV@201174|Actinobacteria,4ERNK@85013|Frankiales	201174|Actinobacteria	E	aminotransferase class I and II	bioF	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008710,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0017144,GO:0018130,GO:0019752,GO:0030312,GO:0032787,GO:0034641,GO:0042364,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.3.1.47,6.2.1.14	ko:K00652,ko:K01906	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03209,R03210,R10124	RC00004,RC00014,RC00039,RC02725	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	iNJ661.Rv1569	Aminotran_1_2,BioW
HKD2_k127_981135_3	105422.BBPM01000041_gene686	6.302e-133	441.0	COG2310@1|root,COG2310@2|Bacteria,2GK6H@201174|Actinobacteria,2NHFE@228398|Streptacidiphilus	201174|Actinobacteria	T	vWA found in TerF C terminus	-	-	-	-	-	-	-	-	-	-	-	-	TerD,vWA-TerF-like
HKD2_k127_981135_5	235985.BBPN01000037_gene545	7.115e-46	175.0	COG2197@1|root,COG2197@2|Bacteria,2H38B@201174|Actinobacteria,2NM6N@228398|Streptacidiphilus	201174|Actinobacteria	T	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HKD2_k127_981135_4	1449976.KALB_3983	7.761e-49	194.0	COG0715@1|root,COG0715@2|Bacteria,2I95I@201174|Actinobacteria,4E1JF@85010|Pseudonocardiales	201174|Actinobacteria	P	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9824119_12	222534.KB893711_gene4955	3.974e-24	106.0	COG0174@1|root,COG0174@2|Bacteria,2GJ2I@201174|Actinobacteria,4ERGV@85013|Frankiales	201174|Actinobacteria	E	PFAM Glutamine synthetase, catalytic	glnA2	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0016787,GO:0016810,GO:0016811,GO:0044464,GO:0050001,GO:0071944	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
HKD2_k127_9824119_9	1048339.KB913029_gene2623	5.714e-49	180.0	2E73E@1|root,331MX@2|Bacteria,2IRHV@201174|Actinobacteria,4EVZR@85013|Frankiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	RHH_1
HKD2_k127_9824119_10	656024.FsymDg_0699	1.43e-27	122.0	COG4634@1|root,COG4634@2|Bacteria,2H16N@201174|Actinobacteria,4EWQX@85013|Frankiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9824119_5	645465.ACUR01000623_gene4642	1.151e-113	383.0	COG0454@1|root,COG0464@1|root,COG0456@2|Bacteria,COG0464@2|Bacteria,2GJ07@201174|Actinobacteria	201174|Actinobacteria	KO	Belongs to the AAA ATPase family	-	-	-	-	-	-	-	-	-	-	-	-	AAA,Acetyltransf_1
HKD2_k127_9824119_0	479432.Sros_3809	7.227e-302	946.0	COG0068@1|root,COG0068@2|Bacteria,2GJYF@201174|Actinobacteria,4EMM0@85012|Streptosporangiales	201174|Actinobacteria	O	HypF finger	-	-	-	ko:K04656	-	-	-	-	ko00000	-	-	-	Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF
HKD2_k127_9824119_1	298653.Franean1_1765	5.22e-296	926.0	COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,2GK2C@201174|Actinobacteria,4ESAT@85013|Frankiales	201174|Actinobacteria	H	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source	nadE	-	6.3.5.1	ko:K01950	ko00760,ko01100,map00760,map01100	M00115	R00257	RC00010,RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase,NAD_synthase
HKD2_k127_9824119_7	298655.KI912267_gene7488	1.815e-63	223.0	COG1309@1|root,COG1309@2|Bacteria,2I9NV@201174|Actinobacteria	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_11,TetR_N
HKD2_k127_9824119_2	58123.JOFJ01000001_gene3224	2.191e-183	590.0	COG0477@1|root,COG2814@2|Bacteria,2H4H5@201174|Actinobacteria,4ER31@85012|Streptosporangiales	201174|Actinobacteria	EGP	Transmembrane secretion effector	-	-	-	ko:K05557	-	-	-	-	ko00000,ko02000	2.A.1.3.7	-	-	MFS_1
HKD2_k127_9824119_3	471852.Tcur_3113	3.423e-118	391.0	COG0413@1|root,COG0413@2|Bacteria,2GJP6@201174|Actinobacteria,4EGTN@85012|Streptosporangiales	201174|Actinobacteria	H	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate	panB	GO:0000287,GO:0003674,GO:0003824,GO:0003864,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016020,GO:0016053,GO:0016740,GO:0016741,GO:0016742,GO:0019752,GO:0032787,GO:0034641,GO:0040007,GO:0042364,GO:0042398,GO:0043167,GO:0043169,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046872,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:0072330,GO:1901564,GO:1901566,GO:1901576	2.1.2.11	ko:K00606	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R01226	RC00022,RC00200	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_transf
HKD2_k127_9824119_4	365528.KB891223_gene1311	2.31e-117	382.0	COG0614@1|root,COG0614@2|Bacteria,2GYJE@201174|Actinobacteria,4ESEY@85013|Frankiales	201174|Actinobacteria	P	ABC-type Fe3 -hydroxamate transport system, periplasmic component	-	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_2
HKD2_k127_9824119_6	68170.KL590477_gene2093	1.685e-64	229.0	COG2085@1|root,COG2085@2|Bacteria,2GMZ5@201174|Actinobacteria,4E13X@85010|Pseudonocardiales	201174|Actinobacteria	S	NADP oxidoreductase coenzyme F420-dependent	npdG	-	1.5.1.40	ko:K06988	-	-	-	-	ko00000,ko01000	-	-	-	F420_oxidored
HKD2_k127_9824119_8	1464048.JNZS01000005_gene5625	2.856e-62	239.0	COG4099@1|root,COG4099@2|Bacteria,2GJDU@201174|Actinobacteria,4DB46@85008|Micromonosporales	201174|Actinobacteria	S	Alpha/beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_8
HKD2_k127_9825307_1	656024.FsymDg_1707	9.394e-183	577.0	COG0176@1|root,COG0176@2|Bacteria,2GMF9@201174|Actinobacteria,4ERZG@85013|Frankiales	201174|Actinobacteria	G	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway	tal	-	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
HKD2_k127_9825307_0	656024.FsymDg_1706	2.968e-290	897.0	COG0364@1|root,COG0364@2|Bacteria,2GISI@201174|Actinobacteria,4ES6Y@85013|Frankiales	201174|Actinobacteria	G	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone	zwf	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	1.1.1.363,1.1.1.49	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	M00004,M00006,M00008	R00835,R02736,R10907	RC00001,RC00066	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	G6PD_C,G6PD_N
HKD2_k127_9825307_6	656024.FsymDg_1705	7.636e-142	463.0	COG3429@1|root,COG3429@2|Bacteria,2GJ1H@201174|Actinobacteria,4ESH3@85013|Frankiales	201174|Actinobacteria	G	dehydrogenase subunit	opcA	-	-	-	-	-	-	-	-	-	-	-	OpcA_G6PD_assem
HKD2_k127_9825307_7	58123.JOFJ01000006_gene158	1.665e-110	362.0	COG0363@1|root,COG0363@2|Bacteria,2GMQ2@201174|Actinobacteria,4EH59@85012|Streptosporangiales	201174|Actinobacteria	G	Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase	pgl	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009051,GO:0009117,GO:0009987,GO:0016020,GO:0016787,GO:0016788,GO:0017057,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046496,GO:0051156,GO:0051186,GO:0052689,GO:0055086,GO:0071704,GO:0071944,GO:0072524,GO:1901135,GO:1901360,GO:1901564	3.1.1.31	ko:K01057	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200	M00004,M00006,M00008	R02035	RC00537	ko00000,ko00001,ko00002,ko01000	-	-	-	Glucosamine_iso
HKD2_k127_9825307_8	106370.Francci3_1642	4.732e-59	208.0	2CNY9@1|root,31GEE@2|Bacteria,2IKKZ@201174|Actinobacteria,4ET09@85013|Frankiales	201174|Actinobacteria	K	Binds to RNA polymerase (RNAP), stimulating transcription from principal, but not alternative sigma factor promoters	rbpA	-	-	-	-	-	-	-	-	-	-	-	RbpA
HKD2_k127_9825307_5	656024.FsymDg_1702	2.494e-157	524.0	COG4166@1|root,COG4166@2|Bacteria,2IIU5@201174|Actinobacteria	201174|Actinobacteria	E	PFAM extracellular solute-binding protein, family 5	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
HKD2_k127_9825307_9	656024.FsymDg_1701	7.592e-27	111.0	COG1314@1|root,COG1314@2|Bacteria,2GR31@201174|Actinobacteria,4ETCT@85013|Frankiales	201174|Actinobacteria	U	PFAM Preprotein translocase SecG subunit	secG	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03075	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecG
HKD2_k127_9825307_2	469371.Tbis_1847	7.429e-165	543.0	COG4608@1|root,COG4608@2|Bacteria,2H4BW@201174|Actinobacteria,4DY53@85010|Pseudonocardiales	201174|Actinobacteria	E	Belongs to the ABC transporter superfamily	appF	-	-	ko:K02032,ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
HKD2_k127_9825307_3	471852.Tcur_2298	1.115e-164	526.0	COG0444@1|root,COG0444@2|Bacteria,2GIXV@201174|Actinobacteria,4EGND@85012|Streptosporangiales	201174|Actinobacteria	EP	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
HKD2_k127_9825307_4	298654.FraEuI1c_4874	6.393e-158	506.0	COG0601@1|root,COG0601@2|Bacteria,2GJ2C@201174|Actinobacteria,4ESWY@85013|Frankiales	201174|Actinobacteria	P	PFAM binding-protein-dependent transport systems inner membrane component	dppB	-	-	ko:K02033,ko:K13890	ko02010,ko02024,map02010,map02024	M00239,M00348	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.11	-	-	BPD_transp_1
HKD2_k127_9842391_6	1306406.ASHX01000001_gene4083	1.29e-61	223.0	COG1470@1|root,COG1470@2|Bacteria,2GP8D@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF3048) C-terminal domain	yerB	-	-	-	-	-	-	-	-	-	-	-	DUF3048,DUF3048_C
HKD2_k127_9842391_7	298654.FraEuI1c_2324	1.74e-38	149.0	COG1704@1|root,COG1704@2|Bacteria,2GK54@201174|Actinobacteria,4ETC5@85013|Frankiales	201174|Actinobacteria	S	LemA family	-	-	-	-	-	-	-	-	-	-	-	-	LemA
HKD2_k127_9842391_2	298655.KI912266_gene5217	4.777e-179	578.0	COG0438@1|root,COG0438@2|Bacteria,2GKQ8@201174|Actinobacteria,4ERG1@85013|Frankiales	201174|Actinobacteria	M	PFAM Glycosyl transferase, group 1	pimA	GO:0000026,GO:0000030,GO:0000287,GO:0003674,GO:0003824,GO:0004376,GO:0004377,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006629,GO:0006643,GO:0006644,GO:0006650,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016758,GO:0019637,GO:0043167,GO:0043169,GO:0043750,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0046467,GO:0046486,GO:0046488,GO:0046872,GO:0070085,GO:0071704,GO:0071944,GO:0097502,GO:1901135,GO:1901137,GO:1901576,GO:1903509	2.4.1.345	ko:K08256	-	-	R11702	-	ko00000,ko01000,ko01003	-	GT4	-	Glyco_trans_1_4,Glyco_transf_4
HKD2_k127_9842391_3	656024.FsymDg_2558	6.765e-130	434.0	COG1560@1|root,COG1560@2|Bacteria,2GM7B@201174|Actinobacteria,4ESDA@85013|Frankiales	201174|Actinobacteria	M	lipid A biosynthesis acyltransferase	htrB	GO:0003674,GO:0003824,GO:0005575,GO:0006629,GO:0006643,GO:0006664,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016740,GO:0016746,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046467,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	2.3.1.265	ko:K22311	-	-	-	-	ko00000,ko01000	-	-	-	Lip_A_acyltrans
HKD2_k127_9842391_4	656024.FsymDg_2559	8.008e-93	311.0	COG0558@1|root,COG0558@2|Bacteria,2GYKW@201174|Actinobacteria,4ESUV@85013|Frankiales	201174|Actinobacteria	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pgsA1	GO:0003674,GO:0003824,GO:0003881,GO:0003882,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016740,GO:0016772,GO:0016780,GO:0017169,GO:0019637,GO:0030312,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044464,GO:0045017,GO:0046474,GO:0046486,GO:0071704,GO:0071944,GO:0090407,GO:1901576	2.7.8.11,2.7.8.5	ko:K00995,ko:K00999	ko00562,ko00564,ko01100,ko04070,map00562,map00564,map01100,map04070	-	R01801,R01802	RC00002,RC00017,RC00078,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
HKD2_k127_9842391_0	28444.JODQ01000017_gene6555	1.011e-314	981.0	COG0480@1|root,COG0480@2|Bacteria,2GKRU@201174|Actinobacteria,4EFYE@85012|Streptosporangiales	201174|Actinobacteria	J	Elongation factor G, domain IV	fusA2	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006790,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0030312,GO:0044237,GO:0044464,GO:0071944	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
HKD2_k127_9842391_5	298655.KI912266_gene5221	3.067e-83	301.0	COG0537@1|root,COG0537@2|Bacteria,2GJT5@201174|Actinobacteria,4ESJ3@85013|Frankiales	201174|Actinobacteria	FG	PFAM Histidine triad (HIT) protein	-	GO:0003674,GO:0003824,GO:0003877,GO:0004551,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008796,GO:0009056,GO:0009058,GO:0009117,GO:0009166,GO:0009987,GO:0015959,GO:0015961,GO:0015965,GO:0015967,GO:0016020,GO:0016462,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0040007,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0070566,GO:0071704,GO:0071944,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576	2.7.7.53	ko:K19710	ko00230,map00230	-	R00126,R01618	RC00002,RC02753,RC02795	ko00000,ko00001,ko01000	-	-	-	HIT
HKD2_k127_9842391_1	1120950.KB892708_gene4256	2.426e-295	919.0	COG0441@1|root,COG0441@2|Bacteria,2GKTC@201174|Actinobacteria,4DN38@85009|Propionibacteriales	201174|Actinobacteria	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA_SAD
HKD2_k127_9842391_8	1121422.AUMW01000012_gene2943	4.182e-09	65.0	COG0394@1|root,COG0394@2|Bacteria,1VA05@1239|Firmicutes,25CRM@186801|Clostridia,262N5@186807|Peptococcaceae	186801|Clostridia	T	Low molecular weight phosphotyrosine protein phosphatase	ywlE	-	3.1.3.48,3.9.1.2	ko:K01104,ko:K20201	-	-	-	-	ko00000,ko01000	-	-	-	LMWPc
HKD2_k127_9882307_0	656024.FsymDg_4119	2.057e-170	550.0	COG0645@1|root,COG2187@1|root,COG0645@2|Bacteria,COG2187@2|Bacteria,2GM3U@201174|Actinobacteria,4EUNB@85013|Frankiales	201174|Actinobacteria	S	AAA domain	-	GO:0003674,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0009987,GO:0030312,GO:0044464,GO:0044764,GO:0046812,GO:0051704,GO:0071944	-	ko:K07028	-	-	-	-	ko00000	-	-	-	AAA_33,APH
HKD2_k127_9882307_2	298655.KI912266_gene2830	1.669e-36	149.0	COG0517@1|root,COG0517@2|Bacteria,2GKSH@201174|Actinobacteria,4ETKN@85013|Frankiales	201174|Actinobacteria	C	PFAM CBS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	BON,CBS
HKD2_k127_9882307_1	518766.Rmar_1010	8.892e-64	234.0	COG0778@1|root,COG0778@2|Bacteria,4NQ04@976|Bacteroidetes	976|Bacteroidetes	C	Nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
## 3621 queries scanned
## Total time (seconds): 133.2404842376709
## Rate: 27.18 q/s