## Tue Feb 17 08:46:37 2026
## emapper-2.1.13
## /data/anaconda3/envs/eggnog-mapper/bin/emapper.py -i /data/result/bins/wyx/bins/HKD2_bin.75.fa -m mmseqs --output HKD2_bin.75 --output_dir /data/result/bins/wyx/eggqs50+/HKD2_bin.75 --itype genome --cpu 8 --override
##
#query	seed_ortholog	evalue	score	eggNOG_OGs	max_annot_lvl	COG_category	Description	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	PFAMs
HKD2_k127_10003951_0	1321778.HMPREF1982_01117	0.0	1345.0	COG3459@1|root,COG3459@2|Bacteria,1TQY8@1239|Firmicutes,248YP@186801|Clostridia	186801|Clostridia	G	Glycosyltransferase 36 associated	ndvB	-	-	-	-	-	-	-	-	-	-	-	DUF3131,Glyco_hydro_36,Glyco_transf_36,Glycoamylase
HKD2_k127_10151540_1	2325.TKV_c16220	1.053e-115	385.0	COG0327@1|root,COG0327@2|Bacteria,1TQ27@1239|Firmicutes,248Q2@186801|Clostridia,42ESG@68295|Thermoanaerobacterales	186801|Clostridia	C	Belongs to the GTP cyclohydrolase I type 2 NIF3 family	-	-	-	-	-	-	-	-	-	-	-	-	NIF3
HKD2_k127_10151540_2	1304284.L21TH_0411	3.432e-52	192.0	COG2384@1|root,COG2384@2|Bacteria,1V3I4@1239|Firmicutes,24BJI@186801|Clostridia,36FNA@31979|Clostridiaceae	186801|Clostridia	S	SAM-dependent methyltransferase	trmK	-	2.1.1.217	ko:K06967	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltransf_18,TrmK
HKD2_k127_10151540_4	509191.AEDB02000003_gene1019	8.438e-08	53.0	2DPV4@1|root,333HA@2|Bacteria,1VH7Z@1239|Firmicutes,24SC2@186801|Clostridia,3WQ8C@541000|Ruminococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_10151540_0	398512.JQKC01000020_gene4050	1.732e-180	571.0	COG0568@1|root,COG0568@2|Bacteria,1TPD6@1239|Firmicutes,2481I@186801|Clostridia,3WGMV@541000|Ruminococcaceae	186801|Clostridia	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	sigA	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
HKD2_k127_10151540_3	555079.Toce_0931	5.153e-37	151.0	COG0305@1|root,COG0358@1|root,COG0305@2|Bacteria,COG0358@2|Bacteria,1TQ0X@1239|Firmicutes,2480W@186801|Clostridia,42EXW@68295|Thermoanaerobacterales	186801|Clostridia	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2
HKD2_k127_10167296_7	428125.CLOLEP_03123	5.929e-17	81.0	2EGRK@1|root,33AHS@2|Bacteria,1VK9R@1239|Firmicutes,24UM0@186801|Clostridia,3WMB3@541000|Ruminococcaceae	186801|Clostridia	S	RSAM-modified six-cysteine peptide	scfA	-	-	-	-	-	-	-	-	-	-	-	SCIFF
HKD2_k127_10167296_6	1408422.JHYF01000001_gene2701	5.385e-24	104.0	COG1862@1|root,COG1862@2|Bacteria,1VEMC@1239|Firmicutes,24MMT@186801|Clostridia,36MPE@31979|Clostridiaceae	186801|Clostridia	U	Preprotein translocase, YajC subunit	yajC	-	-	ko:K03210	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	YajC
HKD2_k127_10167296_0	1031288.AXAA01000005_gene2055	1.296e-198	623.0	COG0343@1|root,COG0343@2|Bacteria,1TNZ4@1239|Firmicutes,247NJ@186801|Clostridia,36FEZ@31979|Clostridiaceae	186801|Clostridia	F	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)	tgt	-	2.4.2.29	ko:K00773	-	-	R03789,R10209	RC00063	ko00000,ko01000,ko03016	-	-	-	TGT
HKD2_k127_10167296_1	941824.TCEL_00385	2.45e-163	519.0	COG0809@1|root,COG0809@2|Bacteria,1TPKD@1239|Firmicutes,247NT@186801|Clostridia,36E77@31979|Clostridiaceae	186801|Clostridia	J	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)	queA	-	2.4.99.17	ko:K07568	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Queuosine_synth
HKD2_k127_10167296_3	1408422.JHYF01000001_gene2698	7.422e-106	364.0	COG2385@1|root,COG2385@2|Bacteria,1UW6J@1239|Firmicutes,24CYM@186801|Clostridia,36DFG@31979|Clostridiaceae	186801|Clostridia	D	TIGRFAM SpoIID LytB domain	lytB	-	-	ko:K06381	-	-	-	-	ko00000	-	-	-	PG_binding_1,SpoIID,Y_Y_Y
HKD2_k127_10167296_2	1304284.L21TH_1275	1.762e-156	499.0	COG2255@1|root,COG2255@2|Bacteria,1TR47@1239|Firmicutes,247W0@186801|Clostridia,36E7R@31979|Clostridiaceae	186801|Clostridia	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing	ruvB	-	3.6.4.12	ko:K03551	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvB_C,RuvB_N
HKD2_k127_10167296_4	509191.AEDB02000103_gene3773	9.996e-46	171.0	COG0632@1|root,COG0632@2|Bacteria,1V3KF@1239|Firmicutes,24JKV@186801|Clostridia,3WIM6@541000|Ruminococcaceae	186801|Clostridia	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB	ruvA	-	3.6.4.12	ko:K03550	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HHH_5,RuvA_C,RuvA_N
HKD2_k127_10167296_5	857293.CAAU_2612	2.122e-24	102.0	COG0817@1|root,COG0817@2|Bacteria,1V3N9@1239|Firmicutes,24HMI@186801|Clostridia,36J15@31979|Clostridiaceae	186801|Clostridia	L	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group	ruvC	-	3.1.22.4	ko:K01159	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvC
HKD2_k127_1235778_0	931626.Awo_c31990	5.122e-52	194.0	COG1402@1|root,COG1402@2|Bacteria,1TT2A@1239|Firmicutes,259JV@186801|Clostridia,25XQC@186806|Eubacteriaceae	186801|Clostridia	S	Creatinine amidohydrolase	-	-	3.5.2.10	ko:K01470	ko00330,map00330	-	R01884	RC00615	ko00000,ko00001,ko01000	-	-	-	Creatininase
HKD2_k127_1235778_1	511051.CSE_02470	1.524e-29	124.0	COG4219@1|root,COG4219@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	LysM,PD40
HKD2_k127_1235778_4	398512.JQKC01000002_gene1977	1.933e-15	85.0	2C8BX@1|root,33682@2|Bacteria,1VNYQ@1239|Firmicutes,24CSZ@186801|Clostridia,3WP9Y@541000|Ruminococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1235778_3	1321778.HMPREF1982_03383	5.627e-20	91.0	2DR5F@1|root,33A90@2|Bacteria,1VK5I@1239|Firmicutes	1239|Firmicutes	S	YvrJ protein family	-	-	-	-	-	-	-	-	-	-	-	-	YvrJ
HKD2_k127_1235778_2	1321778.HMPREF1982_03382	5.434e-21	94.0	COG1595@1|root,COG1595@2|Bacteria,1VNK6@1239|Firmicutes	1239|Firmicutes	K	Belongs to the sigma-70 factor family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_16,Sigma70_r2
HKD2_k127_1284591_3	871968.DESME_05135	3.577e-139	446.0	COG1741@1|root,COG1741@2|Bacteria,1TQDV@1239|Firmicutes,2497R@186801|Clostridia,263S8@186807|Peptococcaceae	186801|Clostridia	S	Belongs to the pirin family	-	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin,Pirin_C
HKD2_k127_1284591_4	1121422.AUMW01000006_gene757	4.516e-125	403.0	COG0745@1|root,COG0745@2|Bacteria,1TP9M@1239|Firmicutes,247TK@186801|Clostridia,260CM@186807|Peptococcaceae	186801|Clostridia	K	PFAM Response regulator receiver domain	phoP_1	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
HKD2_k127_1284591_2	1121422.AUMW01000006_gene756	5.695e-209	668.0	COG0642@1|root,COG2205@2|Bacteria,1TP73@1239|Firmicutes,248Y6@186801|Clostridia,2617A@186807|Peptococcaceae	186801|Clostridia	T	PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
HKD2_k127_1284591_1	536232.CLM_2201	2.141e-211	665.0	COG3263@1|root,COG3263@2|Bacteria,1TQPJ@1239|Firmicutes,2486W@186801|Clostridia,36DFA@31979|Clostridiaceae	186801|Clostridia	P	Sodium/hydrogen exchanger family	-	-	-	ko:K11105	-	-	-	-	ko00000,ko02000	2.A.36.6	-	-	Na_H_Exchanger,TrkA_C
HKD2_k127_1284591_8	1121422.AUMW01000002_gene2215	8.401e-76	259.0	COG1309@1|root,COG1309@2|Bacteria,1VE9T@1239|Firmicutes,25BFA@186801|Clostridia	186801|Clostridia	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
HKD2_k127_1284591_11	865861.AZSU01000002_gene3083	2.069e-24	107.0	COG3976@1|root,COG3976@2|Bacteria,1VFG0@1239|Firmicutes,24RHT@186801|Clostridia,36MVQ@31979|Clostridiaceae	186801|Clostridia	S	PFAM FMN-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	FMN_bind
HKD2_k127_1284591_9	1304284.L21TH_0770	2.579e-49	182.0	COG4635@1|root,COG4635@2|Bacteria,1VBP3@1239|Firmicutes,24JC3@186801|Clostridia,36JH5@31979|Clostridiaceae	186801|Clostridia	CH	Flavodoxin domain	-	-	1.3.5.3	ko:K00230	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R09489	RC00885	ko00000,ko00001,ko00002,ko01000	-	-	-	Flavodoxin_5
HKD2_k127_1284591_6	1262449.CP6013_2822	4.507e-92	311.0	arCOG06802@1|root,2ZBBG@2|Bacteria,1V17K@1239|Firmicutes,24DHN@186801|Clostridia,36IHR@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1284591_0	1120746.CCNL01000009_gene933	3.019e-227	711.0	COG1388@1|root,COG3858@1|root,COG1388@2|Bacteria,COG3858@2|Bacteria,2NQII@2323|unclassified Bacteria	2|Bacteria	M	Glyco_18	yaaH_2	-	-	ko:K06306	-	-	-	-	ko00000	-	-	-	Glyco_hydro_18,LysM
HKD2_k127_1284591_10	398512.JQKC01000029_gene4346	4.236e-47	171.0	COG1695@1|root,COG1695@2|Bacteria,1V85H@1239|Firmicutes,24N2G@186801|Clostridia,3WQBT@541000|Ruminococcaceae	186801|Clostridia	K	Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	PadR
HKD2_k127_1284591_7	398512.JQKC01000029_gene4345	2.509e-81	281.0	COG0604@1|root,COG0604@2|Bacteria,1TT5J@1239|Firmicutes,24IEA@186801|Clostridia,3WPYS@541000|Ruminococcaceae	186801|Clostridia	C	alcohol dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1284591_5	1321778.HMPREF1982_00672	8.877e-99	323.0	COG1592@1|root,COG1592@2|Bacteria,1V1PW@1239|Firmicutes,25B8Q@186801|Clostridia	186801|Clostridia	C	PFAM Rubrerythrin	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
HKD2_k127_1284990_3	720554.Clocl_2786	2.174e-124	410.0	COG0608@1|root,COG0608@2|Bacteria,1TPXE@1239|Firmicutes,247NU@186801|Clostridia,3WI09@541000|Ruminococcaceae	186801|Clostridia	L	exonuclease	recJ	-	-	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1,ssDNA-exonuc_C
HKD2_k127_1284990_4	293826.Amet_2352	1.187e-71	245.0	COG0503@1|root,COG0503@2|Bacteria,1V1BV@1239|Firmicutes,24HGX@186801|Clostridia,36HZI@31979|Clostridiaceae	186801|Clostridia	F	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis	apt	-	2.4.2.7	ko:K00759	ko00230,ko01100,map00230,map01100	-	R00190,R01229,R04378	RC00063	ko00000,ko00001,ko01000,ko04147	-	-	-	Pribosyltran
HKD2_k127_1284990_0	203119.Cthe_1344	6.718e-308	958.0	COG0317@1|root,COG0317@2|Bacteria,1TNYZ@1239|Firmicutes,2489A@186801|Clostridia,3WGUK@541000|Ruminococcaceae	186801|Clostridia	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	relA	-	2.7.6.5	ko:K00951	ko00230,map00230	-	R00429	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	iHN637.CLJU_RS16615	ACT_4,HD_4,RelA_SpoT,TGS
HKD2_k127_1284990_5	1031288.AXAA01000005_gene2044	3.278e-58	205.0	COG1490@1|root,COG1490@2|Bacteria,1V6GH@1239|Firmicutes,24J90@186801|Clostridia,36J4D@31979|Clostridiaceae	186801|Clostridia	J	rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality	dtd	-	-	ko:K07560	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Tyr_Deacylase
HKD2_k127_1284990_6	350688.Clos_1712	2.472e-57	205.0	COG0491@1|root,COG0491@2|Bacteria,1V6FA@1239|Firmicutes,24JGV@186801|Clostridia,36I3Z@31979|Clostridiaceae	186801|Clostridia	S	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HKD2_k127_1284990_2	1292035.H476_0482	3.394e-136	449.0	COG0635@1|root,COG0635@2|Bacteria,1TREM@1239|Firmicutes,247JT@186801|Clostridia,25QG9@186804|Peptostreptococcaceae	186801|Clostridia	H	coproporphyrinogen III oxidase	hemZ	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
HKD2_k127_1284990_1	1304284.L21TH_1254	1.698e-177	565.0	COG0124@1|root,COG0124@2|Bacteria,1TP3D@1239|Firmicutes,24852@186801|Clostridia,36FA9@31979|Clostridiaceae	186801|Clostridia	J	histidyl-tRNA synthetase	hisS	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
HKD2_k127_1284990_7	1243664.CAVL020000006_gene4857	7.963e-18	83.0	COG0173@1|root,COG0173@2|Bacteria,1TPCN@1239|Firmicutes,4HACD@91061|Bacilli,1ZBXI@1386|Bacillus	91061|Bacilli	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
HKD2_k127_1286680_2	1304284.L21TH_2699	4.298e-142	463.0	COG1149@1|root,COG4624@1|root,COG1149@2|Bacteria,COG4624@2|Bacteria,1TQIR@1239|Firmicutes,248BS@186801|Clostridia,36E6A@31979|Clostridiaceae	186801|Clostridia	C	-hydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Fe_hyd_lg_C,Fer4
HKD2_k127_1286680_0	857293.CAAU_0572	2.147e-166	531.0	COG0301@1|root,COG0301@2|Bacteria,1TPNW@1239|Firmicutes,247Y5@186801|Clostridia,36DP3@31979|Clostridiaceae	186801|Clostridia	H	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS	thiI	-	2.8.1.4	ko:K03151	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07461	-	ko00000,ko00001,ko01000,ko03016	-	-	-	THUMP,ThiI
HKD2_k127_1286680_1	857293.CAAU_0573	2.398e-148	479.0	COG1104@1|root,COG1104@2|Bacteria,1TP21@1239|Firmicutes,24888@186801|Clostridia,36ECQ@31979|Clostridiaceae	186801|Clostridia	E	Cysteine desulfurase	iscS	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
HKD2_k127_1324727_0	203119.Cthe_0460	1.028e-282	883.0	COG0550@1|root,COG0550@2|Bacteria,1TPUS@1239|Firmicutes,248MG@186801|Clostridia,3WGDZ@541000|Ruminococcaceae	186801|Clostridia	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,zf-C4_Topoisom
HKD2_k127_1324727_2	1121423.JONT01000004_gene1590	1.142e-187	595.0	COG1206@1|root,COG1206@2|Bacteria,1TP67@1239|Firmicutes,24971@186801|Clostridia,260G4@186807|Peptococcaceae	186801|Clostridia	J	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs	trmFO	-	2.1.1.74	ko:K04094	-	-	-	-	ko00000,ko01000,ko03016,ko03036	-	-	-	GIDA
HKD2_k127_1324727_6	340099.Teth39_1263	2.119e-79	268.0	COG5405@1|root,COG5405@2|Bacteria,1TPXK@1239|Firmicutes,24FS4@186801|Clostridia,42G10@68295|Thermoanaerobacterales	186801|Clostridia	O	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery	hslV	-	3.4.25.2	ko:K01419	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Proteasome
HKD2_k127_1324727_3	697284.ERIC2_c21750	5.337e-184	586.0	COG1220@1|root,COG1220@2|Bacteria,1TPKQ@1239|Firmicutes,4HA83@91061|Bacilli,26TEX@186822|Paenibacillaceae	91061|Bacilli	O	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis	hslU	-	-	ko:K03667	-	-	-	-	ko00000,ko03110	-	-	-	AAA_2,ClpB_D2-small
HKD2_k127_1324727_5	1540257.JQMW01000009_gene3576	6.407e-104	343.0	COG4465@1|root,COG4465@2|Bacteria,1TS7A@1239|Firmicutes,2480R@186801|Clostridia,36E2I@31979|Clostridiaceae	186801|Clostridia	K	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor	codY	-	-	ko:K03706	-	-	-	-	ko00000,ko03000	-	-	-	CodY,HTH_CodY
HKD2_k127_1324727_9	1304880.JAGB01000001_gene181	2.111e-32	130.0	COG1815@1|root,COG1815@2|Bacteria,1VEUZ@1239|Firmicutes,24RBE@186801|Clostridia	186801|Clostridia	N	Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body	flgB	-	-	ko:K02387	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod
HKD2_k127_1324727_8	720554.Clocl_1969	4.143e-64	222.0	COG1558@1|root,COG1558@2|Bacteria,1V6NB@1239|Firmicutes,24JJW@186801|Clostridia,3WK29@541000|Ruminococcaceae	186801|Clostridia	N	Belongs to the flagella basal body rod proteins family	flgC	-	-	ko:K02388	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod,Flg_bbr_C
HKD2_k127_1324727_10	1195236.CTER_2998	3.79e-21	96.0	COG1677@1|root,COG1677@2|Bacteria,1URG4@1239|Firmicutes,259BU@186801|Clostridia,3WMM0@541000|Ruminococcaceae	186801|Clostridia	NU	Flagellar hook-basal body complex protein FliE	-	-	-	-	-	-	-	-	-	-	-	-	FliE
HKD2_k127_1324727_7	1304284.L21TH_2658	1.774e-74	270.0	COG1766@1|root,COG1766@2|Bacteria,1TRK0@1239|Firmicutes,2498Q@186801|Clostridia,36FDA@31979|Clostridiaceae	186801|Clostridia	N	The M ring may be actively involved in energy transduction	fliF	-	-	ko:K02409	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	YscJ_FliF,YscJ_FliF_C
HKD2_k127_1324727_4	588581.Cpap_0638	9.149e-170	537.0	COG1536@1|root,COG1536@2|Bacteria,1TP01@1239|Firmicutes,2480B@186801|Clostridia,3WHE9@541000|Ruminococcaceae	186801|Clostridia	N	flagellar motor switch protein	fliG	-	-	ko:K02410	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliG_C,FliG_M,FliG_N
HKD2_k127_1324727_11	632335.Calkr_0408	4.905e-19	96.0	COG1317@1|root,COG1317@2|Bacteria,1VEUV@1239|Firmicutes,24QUG@186801|Clostridia,42HAC@68295|Thermoanaerobacterales	186801|Clostridia	N	PFAM Flagellar assembly protein FliH Type III secretion system HrpE	fliH	-	-	ko:K02411	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	FliH
HKD2_k127_1324727_1	350688.Clos_1482	2.99e-193	611.0	COG1157@1|root,COG1157@2|Bacteria,1TP0R@1239|Firmicutes,25E6B@186801|Clostridia,36FF4@31979|Clostridiaceae	186801|Clostridia	NU	Flagellar protein export ATPase FliI	fliI	-	3.6.3.14	ko:K02412,ko:K03224	ko02040,ko03070,map02040,map03070	M00332,M00542,M00660	-	-	ko00000,ko00001,ko00002,ko01000,ko02035,ko02044	3.A.6.1,3.A.6.2,3.A.6.3	-	-	ATP-synt_ab,ATP-synt_ab_N
HKD2_k127_1324727_12	509191.AEDB02000074_gene1760	3.276e-16	84.0	COG2882@1|root,COG2882@2|Bacteria,1VK96@1239|Firmicutes,24RWK@186801|Clostridia,3WJZT@541000|Ruminococcaceae	186801|Clostridia	N	TIGRFAM flagellar export protein FliJ	fliJ	-	-	ko:K02413	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliJ
HKD2_k127_1324727_13	340099.Teth39_1252	6.086e-08	62.0	COG3334@1|root,COG3334@2|Bacteria,1VHUP@1239|Firmicutes,24SPP@186801|Clostridia,42GXM@68295|Thermoanaerobacterales	186801|Clostridia	S	MgtE intracellular N domain	-	-	-	ko:K02383	-	-	-	-	ko00000,ko02035	-	-	-	MgtE_N,PKcGMP_CC
HKD2_k127_1333816_2	1121121.KB894333_gene4598	5.513e-07	51.0	2ED1A@1|root,336Y8@2|Bacteria,1VNP3@1239|Firmicutes,4HRCX@91061|Bacilli	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1333816_3	537972.ABQU01000006_gene303	2.418e-06	58.0	COG1077@1|root,COG1077@2|Bacteria,1MUMW@1224|Proteobacteria,42M1J@68525|delta/epsilon subdivisions,2YMHT@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	D	rod shape-determining protein mreB	mreB	-	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
HKD2_k127_1333816_1	1121346.KB899808_gene3579	5.553e-24	106.0	COG2764@1|root,COG2764@2|Bacteria,1V3WE@1239|Firmicutes,4HHHS@91061|Bacilli,26XJK@186822|Paenibacillaceae	91061|Bacilli	S	Glyoxalase	phnB7	-	-	ko:K04750	-	-	-	-	ko00000	-	-	-	3-dmu-9_3-mt
HKD2_k127_1333816_0	350688.Clos_1560	4.05e-108	355.0	COG1352@1|root,COG1352@2|Bacteria,1TPD8@1239|Firmicutes,24AQJ@186801|Clostridia,36F2I@31979|Clostridiaceae	186801|Clostridia	NT	Methyltransferase	cheR	-	2.1.1.80	ko:K00575	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko01000,ko02035	-	-	-	CheR,CheR_N
HKD2_k127_1335411_4	1294142.CINTURNW_1493	5.137e-69	243.0	COG0457@1|root,COG2357@1|root,COG0457@2|Bacteria,COG2357@2|Bacteria,1UFII@1239|Firmicutes,24GAE@186801|Clostridia	186801|Clostridia	S	Region found in RelA / SpoT proteins	-	-	-	-	-	-	-	-	-	-	-	-	RelA_SpoT
HKD2_k127_1335411_1	398512.JQKC01000004_gene5218	3.619e-85	299.0	COG1961@1|root,COG1961@2|Bacteria,1TPUG@1239|Firmicutes,25B03@186801|Clostridia,3WGW2@541000|Ruminococcaceae	186801|Clostridia	L	Psort location Cytoplasmic, score	-	-	-	ko:K06400	-	-	-	-	ko00000	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
HKD2_k127_1335411_7	1449050.JNLE01000003_gene3542	3.388e-32	128.0	COG0452@1|root,COG0452@2|Bacteria,1TQPT@1239|Firmicutes,24HE6@186801|Clostridia,36I49@31979|Clostridiaceae	186801|Clostridia	H	Together with DpaA, catalyzes the conversion of dihydrodipicolinate to dipicolinate (DPA)	spoVFB	-	-	ko:K06411	-	-	-	-	ko00000	-	-	-	Flavoprotein
HKD2_k127_1335411_5	351627.Csac_2146	1.103e-62	227.0	COG1052@1|root,COG1052@2|Bacteria,1UI1W@1239|Firmicutes,25F6V@186801|Clostridia,42GM8@68295|Thermoanaerobacterales	186801|Clostridia	CH	PFAM D-isomer specific 2-hydroxyacid dehydrogenase	-	-	-	ko:K06410	-	-	-	-	ko00000	-	-	-	2-Hacid_dh_C,DpaA_N
HKD2_k127_1335411_8	1391646.AVSU01000058_gene1016	7.823e-20	91.0	COG1873@1|root,COG1873@2|Bacteria,1VEJW@1239|Firmicutes,25JAQ@186801|Clostridia,25RRI@186804|Peptostreptococcaceae	186801|Clostridia	S	PRC-barrel domain	-	-	-	-	-	-	-	-	-	-	-	-	PRC
HKD2_k127_1335411_6	1120973.AQXL01000128_gene2800	9.285e-47	172.0	COG0756@1|root,COG0756@2|Bacteria,1V6HX@1239|Firmicutes,4HIZ3@91061|Bacilli,27A0Q@186823|Alicyclobacillaceae	91061|Bacilli	F	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA	dut	-	3.6.1.23	ko:K01520	ko00240,ko00983,ko01100,map00240,map00983,map01100	M00053	R02100,R11896	RC00002	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	dUTPase
HKD2_k127_1335411_0	203119.Cthe_0419	1.039e-148	482.0	COG0612@1|root,COG0612@2|Bacteria,1TP5I@1239|Firmicutes,248HT@186801|Clostridia,3WGIJ@541000|Ruminococcaceae	186801|Clostridia	S	Belongs to the peptidase M16 family	ymxG	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
HKD2_k127_1335411_2	1304880.JAGB01000001_gene241	7.177e-73	254.0	COG0726@1|root,COG0726@2|Bacteria,1TQ5M@1239|Firmicutes,25B0J@186801|Clostridia	186801|Clostridia	G	PFAM Polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
HKD2_k127_1335411_3	931276.Cspa_c40200	3.545e-69	248.0	COG3973@1|root,COG3973@2|Bacteria,1TP39@1239|Firmicutes,249IG@186801|Clostridia,36E3M@31979|Clostridiaceae	186801|Clostridia	L	DNA helicase	helD1	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AAA_19,UvrD-helicase,UvrD_C,UvrD_C_2
HKD2_k127_1350952_5	857293.CAAU_0426	2.955e-61	212.0	COG1156@1|root,COG1156@2|Bacteria,1VSU1@1239|Firmicutes,2496H@186801|Clostridia,36DRP@31979|Clostridiaceae	186801|Clostridia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit	atpB	-	-	ko:K02118	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N
HKD2_k127_1350952_3	1410653.JHVC01000001_gene1760	3.253e-82	278.0	COG1394@1|root,COG1394@2|Bacteria,1TQ1Y@1239|Firmicutes,247TC@186801|Clostridia,36E0U@31979|Clostridiaceae	186801|Clostridia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpD	-	-	ko:K02120	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_D
HKD2_k127_1350952_9	1291050.JAGE01000002_gene3786	1.092e-08	58.0	2DRK3@1|root,33C54@2|Bacteria,1VP7P@1239|Firmicutes,24W5A@186801|Clostridia,3WQSV@541000|Ruminococcaceae	186801|Clostridia	S	Domain of Unknown Function (DUF1540)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1540
HKD2_k127_1350952_6	1121468.AUBR01000004_gene168	3.051e-38	145.0	COG1592@1|root,COG1592@2|Bacteria,1VB12@1239|Firmicutes,24JQ6@186801|Clostridia,42H0K@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM Rubredoxin-type Fe(Cys)4 protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1350952_0	865861.AZSU01000002_gene2377	3.297e-178	565.0	COG1167@1|root,COG1167@2|Bacteria,1TPS5@1239|Firmicutes,248ZB@186801|Clostridia,36EK3@31979|Clostridiaceae	186801|Clostridia	K	aminotransferase class I and II	-	-	-	ko:K05825	ko00300,ko01100,ko01130,ko01210,map00300,map01100,map01130,map01210	-	R01939	RC00006	ko00000,ko00001,ko01000	-	-	-	Aminotran_1_2
HKD2_k127_1350952_8	755731.Clo1100_3947	2.042e-28	114.0	COG1773@1|root,COG1773@2|Bacteria,1VEQC@1239|Firmicutes,24QUV@186801|Clostridia,36MM3@31979|Clostridiaceae	186801|Clostridia	C	PFAM Rubredoxin-type Fe(Cys)4 protein	rd	GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0016491,GO:0017144,GO:0022900,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914,GO:0055114,GO:0072592	-	-	-	-	-	-	-	-	-	-	Rubredoxin
HKD2_k127_1350952_2	858215.Thexy_0783	2.1e-115	379.0	COG1313@1|root,COG1313@2|Bacteria,1TRUV@1239|Firmicutes,247VW@186801|Clostridia,42FFV@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM Radical SAM domain protein	PflX	-	1.97.1.4	ko:K04070	-	-	-	-	ko00000,ko01000	-	-	-	Fer4_12,Fer4_14,Radical_SAM
HKD2_k127_1350952_7	1540257.JQMW01000014_gene84	9.659e-30	125.0	COG4189@1|root,COG4189@2|Bacteria,1UHX2@1239|Firmicutes,25E60@186801|Clostridia,36P7F@31979|Clostridiaceae	186801|Clostridia	K	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
HKD2_k127_1350952_4	1540257.JQMW01000011_gene2497	1.469e-62	232.0	COG0477@1|root,COG2814@2|Bacteria,1UZPE@1239|Firmicutes,2490R@186801|Clostridia,36V8V@31979|Clostridiaceae	186801|Clostridia	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD2_k127_1350952_1	293826.Amet_4411	3.953e-147	487.0	COG0642@1|root,COG2205@2|Bacteria,1TQMV@1239|Firmicutes,247SE@186801|Clostridia,36HR5@31979|Clostridiaceae	186801|Clostridia	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3,PAS_9,PocR,dCache_1
HKD2_k127_1350952_10	1499689.CCNN01000011_gene2982	2.499e-07	53.0	COG2096@1|root,COG2096@2|Bacteria,1V3PI@1239|Firmicutes,24C7G@186801|Clostridia,36GUU@31979|Clostridiaceae	186801|Clostridia	S	adenosyltransferase	-	-	2.5.1.17	ko:K00798	ko00860,ko01100,map00860,map01100	M00122	R01492,R05220,R07268	RC00533	ko00000,ko00001,ko00002,ko01000	-	-	-	Cob_adeno_trans,Haem_degrading
HKD2_k127_1366360_6	1304284.L21TH_0247	5.251e-89	306.0	COG0860@1|root,COG2385@1|root,COG0860@2|Bacteria,COG2385@2|Bacteria,1UYPW@1239|Firmicutes,24CB9@186801|Clostridia,36EPH@31979|Clostridiaceae	186801|Clostridia	DM	Ami_3	-	-	-	-	-	-	-	-	-	-	-	-	Amidase_3,SpoIID
HKD2_k127_1366360_7	195103.CPF_2481	7.634e-88	299.0	28HCB@1|root,2Z7P7@2|Bacteria,1TNZK@1239|Firmicutes,2487N@186801|Clostridia,36E05@31979|Clostridiaceae	186801|Clostridia	S	sporulation peptidase YabG	yabG	-	-	ko:K06436	-	-	-	-	ko00000	-	-	-	Peptidase_U57
HKD2_k127_1366360_9	1414720.CBYM010000021_gene2144	1.141e-71	253.0	COG2334@1|root,COG2334@2|Bacteria,1TTBS@1239|Firmicutes,2483F@186801|Clostridia,36DMN@31979|Clostridiaceae	186801|Clostridia	S	spore coat protein, CotS	cotS	-	-	ko:K06331,ko:K06337	-	-	-	-	ko00000	-	-	-	APH,Choline_kinase
HKD2_k127_1366360_12	1499684.CCNP01000018_gene534	2.976e-42	168.0	COG2334@1|root,COG2334@2|Bacteria,1TTBS@1239|Firmicutes,2483F@186801|Clostridia,36DMN@31979|Clostridiaceae	186801|Clostridia	S	spore coat protein, CotS	cotS	-	-	ko:K06331,ko:K06337	-	-	-	-	ko00000	-	-	-	APH,Choline_kinase
HKD2_k127_1366360_13	1216932.CM240_2317	2.208e-28	127.0	COG2334@1|root,COG2334@2|Bacteria,1TTBS@1239|Firmicutes,2483F@186801|Clostridia,36DMN@31979|Clostridiaceae	186801|Clostridia	S	spore coat protein, CotS	cotS	-	-	ko:K06331,ko:K06337	-	-	-	-	ko00000	-	-	-	APH,Choline_kinase
HKD2_k127_1366360_8	1031288.AXAA01000013_gene495	2.027e-78	273.0	COG2334@1|root,COG2334@2|Bacteria,1V9C3@1239|Firmicutes,248DT@186801|Clostridia,36EAM@31979|Clostridiaceae	186801|Clostridia	S	Spore coat protein	-	-	-	-	-	-	-	-	-	-	-	-	APH,Choline_kinase
HKD2_k127_1366360_4	1031288.AXAA01000013_gene496	2.073e-117	388.0	COG0438@1|root,COG0438@2|Bacteria,1UASH@1239|Firmicutes,248VW@186801|Clostridia,36DY2@31979|Clostridiaceae	186801|Clostridia	M	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
HKD2_k127_1366360_3	941824.TCEL_00111	8.549e-122	402.0	COG0836@1|root,COG0836@2|Bacteria,1TPC9@1239|Firmicutes,24908@186801|Clostridia,36DFS@31979|Clostridiaceae	186801|Clostridia	M	mannose-1-phosphate guanylyltransferase	manC	-	2.7.7.13	ko:K00971	ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110	M00114,M00361,M00362	R00885	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS00940	MannoseP_isomer,NTP_transferase
HKD2_k127_1366360_11	871968.DESME_09520	1.452e-46	169.0	COG3369@1|root,COG3369@2|Bacteria,1VC9E@1239|Firmicutes,24R4M@186801|Clostridia	186801|Clostridia	S	Iron-binding zinc finger CDGSH type	-	-	-	-	-	-	-	-	-	-	-	-	zf-CDGSH
HKD2_k127_1366360_5	536227.CcarbDRAFT_1884	2.855e-90	301.0	COG3560@1|root,COG3560@2|Bacteria,1V1CR@1239|Firmicutes,2481A@186801|Clostridia,36FAX@31979|Clostridiaceae	186801|Clostridia	S	PFAM Nitroreductase	-	-	-	ko:K07078	-	-	-	-	ko00000	-	-	-	Nitroreductase
HKD2_k127_1366360_15	290402.Cbei_4355	4.764e-15	81.0	COG2846@1|root,COG2846@2|Bacteria,1VGYW@1239|Firmicutes,24RAK@186801|Clostridia,36NBW@31979|Clostridiaceae	186801|Clostridia	D	PFAM Hemerythrin HHE cation binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
HKD2_k127_1366360_14	536227.CcarbDRAFT_0487	5.606e-23	98.0	COG2846@1|root,COG2846@2|Bacteria,1VET8@1239|Firmicutes,24QPY@186801|Clostridia,36MJC@31979|Clostridiaceae	186801|Clostridia	D	cluster protein-associated redox disulfide domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF1858
HKD2_k127_1366360_10	536227.CcarbDRAFT_0486	1.479e-65	226.0	COG1846@1|root,COG1846@2|Bacteria,1VB3Q@1239|Firmicutes,25CPU@186801|Clostridia,36WYX@31979|Clostridiaceae	186801|Clostridia	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
HKD2_k127_1366360_1	1304284.L21TH_0132	4.464e-138	444.0	COG1879@1|root,COG1879@2|Bacteria,1TQ1B@1239|Firmicutes,247K8@186801|Clostridia,36DBX@31979|Clostridiaceae	186801|Clostridia	G	PFAM periplasmic binding protein	rbsB	-	-	ko:K10439	ko02010,ko02030,map02010,map02030	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	Peripla_BP_4
HKD2_k127_1366360_2	1304284.L21TH_0133	1.295e-128	418.0	COG1172@1|root,COG1172@2|Bacteria,1TP72@1239|Firmicutes,249FA@186801|Clostridia,36DTM@31979|Clostridiaceae	186801|Clostridia	G	Belongs to the binding-protein-dependent transport system permease family	rbsC	-	-	ko:K10440	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	BPD_transp_2
HKD2_k127_1366360_0	1304284.L21TH_0134	9.46e-214	674.0	COG1129@1|root,COG1129@2|Bacteria,1TP6I@1239|Firmicutes,247II@186801|Clostridia,36DME@31979|Clostridiaceae	186801|Clostridia	P	import. Responsible for energy coupling to the transport system	rbsA	-	3.6.3.17	ko:K10441,ko:K10542	ko02010,map02010	M00212,M00214	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19,3.A.1.2.3	-	-	ABC_tran
HKD2_k127_1366360_16	1301100.HG529275_gene1621	2.146e-11	64.0	COG1869@1|root,COG1869@2|Bacteria,1VA2V@1239|Firmicutes,24MPJ@186801|Clostridia,36IY3@31979|Clostridiaceae	186801|Clostridia	G	Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose	rbsD	-	5.4.99.62	ko:K06726	ko02010,map02010	-	R08247	RC02247	ko00000,ko00001,ko01000	-	-	-	RbsD_FucU
HKD2_k127_1374806_1	1132442.KB889752_gene1475	2.723e-97	319.0	COG0574@1|root,COG3848@1|root,COG0574@2|Bacteria,COG3848@2|Bacteria,1UYA0@1239|Firmicutes,4HD4S@91061|Bacilli,1ZAW5@1386|Bacillus	91061|Bacilli	GT	phosphoenolpyruvate synthase	pps	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PPDK_N
HKD2_k127_1374806_3	203119.Cthe_1700	4.149e-09	59.0	COG1961@1|root,COG1961@2|Bacteria,1TPBH@1239|Firmicutes,248J7@186801|Clostridia,3WGKH@541000|Ruminococcaceae	186801|Clostridia	L	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
HKD2_k127_1374806_2	1395587.P364_0118375	4.009e-18	84.0	COG4430@1|root,COG4430@2|Bacteria,1UYP9@1239|Firmicutes,4HDZD@91061|Bacilli,26RX5@186822|Paenibacillaceae	91061|Bacilli	S	Bacteriocin-protection, YdeI or OmpD-Associated	ydeI	-	-	-	-	-	-	-	-	-	-	-	DUF1801,OmdA
HKD2_k127_1374806_0	756499.Desde_3616	4.245e-160	508.0	COG1695@1|root,COG1695@2|Bacteria,1UYVX@1239|Firmicutes,25B6J@186801|Clostridia,261U7@186807|Peptococcaceae	186801|Clostridia	K	Virulence activator alpha C-term	-	-	-	-	-	-	-	-	-	-	-	-	DUF4180,PadR,Vir_act_alpha_C
HKD2_k127_137809_0	536227.CcarbDRAFT_2336	4.684e-221	693.0	COG0697@1|root,COG0697@2|Bacteria,1TP7K@1239|Firmicutes,248Q8@186801|Clostridia,36DVY@31979|Clostridiaceae	186801|Clostridia	EG	Spore germination protein	-	-	-	ko:K06295,ko:K06310	-	-	-	-	ko00000	-	-	-	GerA
HKD2_k127_137809_1	1487921.DP68_06655	2.411e-57	201.0	COG0116@1|root,COG0116@2|Bacteria,1TT5F@1239|Firmicutes,249VY@186801|Clostridia,36G84@31979|Clostridiaceae	186801|Clostridia	L	Putative RNA methylase family UPF0020	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,UPF0020
HKD2_k127_1383921_1	1158607.UAU_03083	2.127e-136	440.0	COG1082@1|root,COG1082@2|Bacteria,1UY4G@1239|Firmicutes,4I81H@91061|Bacilli,4B19R@81852|Enterococcaceae	91061|Bacilli	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
HKD2_k127_1383921_0	931276.Cspa_c43270	1.358e-199	643.0	COG3664@1|root,COG4977@1|root,COG3664@2|Bacteria,COG4977@2|Bacteria,1TQGI@1239|Firmicutes,2490Q@186801|Clostridia,36GCA@31979|Clostridiaceae	186801|Clostridia	K	family 39	-	-	3.2.1.37	ko:K01198	ko00520,ko01100,map00520,map01100	-	R01433	RC00467	ko00000,ko00001,ko01000	-	GH43	-	AraC_binding,Cupin_2,Glyco_hydro_39,HTH_18
HKD2_k127_1393320_3	293826.Amet_3538	2.565e-74	260.0	COG1109@1|root,COG1208@1|root,COG1109@2|Bacteria,COG1208@2|Bacteria,1VDBC@1239|Firmicutes,24AGU@186801|Clostridia,36UK6@31979|Clostridiaceae	186801|Clostridia	GJM	phosphoglucomutase phosphomannomutase alpha beta alpha domain I	-	-	2.7.7.13,5.4.2.8	ko:K00966,ko:K16881	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114,M00361,M00362	R00885,R01818	RC00002,RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase,PGM_PMM_I
HKD2_k127_1393320_0	720554.Clocl_3028	0.0	2931.0	COG3459@1|root,COG3459@2|Bacteria,1TQY8@1239|Firmicutes,248YP@186801|Clostridia,3WGK9@541000|Ruminococcaceae	186801|Clostridia	G	Glycosyltransferase family 36	ndvB	-	-	-	-	-	-	-	-	-	-	-	DUF3131,Glyco_hydro_36,Glyco_transf_36,Glycoamylase
HKD2_k127_1393320_5	1304284.L21TH_1997	6.302e-30	121.0	COG4472@1|root,COG4472@2|Bacteria,1VAC4@1239|Firmicutes,24QVQ@186801|Clostridia,36KEY@31979|Clostridiaceae	186801|Clostridia	S	Belongs to the UPF0297 family	yrzL	-	-	-	-	-	-	-	-	-	-	-	DUF965
HKD2_k127_1393320_2	350688.Clos_1664	8.207e-88	317.0	COG3119@1|root,COG3119@2|Bacteria,1TSMM@1239|Firmicutes,247YU@186801|Clostridia,36G9T@31979|Clostridiaceae	186801|Clostridia	P	arylsulfatase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1393320_1	203119.Cthe_0152	1.091e-114	377.0	COG0667@1|root,COG1148@1|root,COG0667@2|Bacteria,COG1148@2|Bacteria,1UHXA@1239|Firmicutes,25E68@186801|Clostridia,3WN0I@541000|Ruminococcaceae	186801|Clostridia	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red,Fer4
HKD2_k127_1393320_4	340099.Teth39_1054	3.778e-46	170.0	COG0816@1|root,COG0816@2|Bacteria,1V6ER@1239|Firmicutes,24JGP@186801|Clostridia,42GK6@68295|Thermoanaerobacterales	186801|Clostridia	J	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA	yrrK	-	-	ko:K07447	-	-	-	-	ko00000,ko01000	-	-	-	RuvX
HKD2_k127_1401867_1	536227.CcarbDRAFT_0792	3.846e-53	191.0	COG4636@1|root,COG4636@2|Bacteria,1V0MZ@1239|Firmicutes,24J20@186801|Clostridia,36KAN@31979|Clostridiaceae	186801|Clostridia	S	Putative restriction endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	Uma2
HKD2_k127_1401867_0	1321778.HMPREF1982_03105	2.174e-182	574.0	COG0436@1|root,COG0436@2|Bacteria,1TQP8@1239|Firmicutes,24BFE@186801|Clostridia,26APK@186813|unclassified Clostridiales	186801|Clostridia	E	Aminotransferase class I and II	aspD	-	4.1.1.12	ko:K09758	ko00250,ko00270,ko01100,ko01230,map00250,map00270,map01100,map01230	-	R00397,R00863	RC00282,RC00399,RC00400	ko00000,ko00001,ko01000	-	-	-	Aminotran_1_2
HKD2_k127_1404349_1	555079.Toce_0607	1.198e-114	375.0	COG0500@1|root,COG2226@2|Bacteria,1U5XV@1239|Firmicutes,24A44@186801|Clostridia,42HTN@68295|Thermoanaerobacterales	186801|Clostridia	Q	Hypothetical methyltransferase	arsM	-	2.1.1.137	ko:K07755	-	-	-	-	ko00000,ko01000	-	-	-	Methyltransf_31
HKD2_k127_1404349_3	555079.Toce_0455	5.787e-53	190.0	COG1846@1|root,COG1846@2|Bacteria,1V9AQ@1239|Firmicutes,24GW2@186801|Clostridia	186801|Clostridia	K	MarR family	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
HKD2_k127_1404349_4	350688.Clos_1115	3.079e-38	147.0	COG0607@1|root,COG0607@2|Bacteria	2|Bacteria	P	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS	yrkH	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B,Rhodanese
HKD2_k127_1404349_0	1230342.CTM_00615	9.451e-267	830.0	COG0446@1|root,COG0446@2|Bacteria,1TPWW@1239|Firmicutes,2484C@186801|Clostridia,36EYM@31979|Clostridiaceae	186801|Clostridia	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation	-	-	-	-	-	-	-	-	-	-	-	-	DrsE_2,Fer4,NIR_SIR,NIR_SIR_ferr,Pyr_redox_2,Pyr_redox_dim,Rhodanese,TusA
HKD2_k127_1404349_2	1410653.JHVC01000009_gene2678	5.472e-112	363.0	COG0003@1|root,COG0003@2|Bacteria,1TQZP@1239|Firmicutes,249JN@186801|Clostridia,36EXQ@31979|Clostridiaceae	186801|Clostridia	D	TIGRFAM arsenite-activated ATPase ArsA	arsA	-	3.6.3.16	ko:K01551	-	-	-	-	ko00000,ko01000,ko02000	3.A.19.1,3.A.21.1,3.A.4.1	-	-	ArsA_ATPase
HKD2_k127_1404705_7	1121289.JHVL01000024_gene122	5.082e-90	302.0	COG1477@1|root,COG1477@2|Bacteria,1TR9C@1239|Firmicutes,248KJ@186801|Clostridia,36DZZ@31979|Clostridiaceae	186801|Clostridia	H	Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein	apbE	-	2.7.1.180	ko:K03734	-	-	-	-	ko00000,ko01000	-	-	-	ApbE
HKD2_k127_1404705_1	332101.JIBU02000019_gene2098	1.936e-292	900.0	COG0043@1|root,COG0043@2|Bacteria,1TQ6V@1239|Firmicutes,248WY@186801|Clostridia,36G19@31979|Clostridiaceae	186801|Clostridia	H	Belongs to the UbiD family	-	-	4.1.1.61,4.1.1.98	ko:K03182,ko:K16239	ko00130,ko00627,ko01100,ko01110,ko01120,map00130,map00627,map01100,map01110,map01120	M00117	R01238,R04985,R04986	RC00391	ko00000,ko00001,ko00002,ko01000	-	-	-	UbiD
HKD2_k127_1404705_5	562743.JH976446_gene640	1.055e-113	374.0	COG0382@1|root,COG0382@2|Bacteria,1TQU5@1239|Firmicutes,4HAGP@91061|Bacilli	91061|Bacilli	H	4-hydroxybenzoate polyprenyltransferase	-	-	2.5.1.39	ko:K03179	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R05000,R05615	RC00209,RC02895	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
HKD2_k127_1404705_8	562743.JH976446_gene639	1.908e-84	283.0	COG0163@1|root,COG0163@2|Bacteria,1V3JV@1239|Firmicutes,4HFZX@91061|Bacilli	91061|Bacilli	H	Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN	ubiX	-	2.5.1.129	ko:K03186	ko00130,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00627,map00940,map01100,map01110,map01120,map01220	M00117	R01238,R02952,R03367,R04985,R04986,R11225	RC00391,RC00814,RC03392	ko00000,ko00001,ko00002,ko01000	-	-	-	Flavoprotein
HKD2_k127_1404705_4	1321778.HMPREF1982_03365	1.366e-119	389.0	COG0715@1|root,COG0715@2|Bacteria,1UY07@1239|Firmicutes,24EN3@186801|Clostridia	186801|Clostridia	P	ABC-type nitrate sulfonate bicarbonate transport	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
HKD2_k127_1404705_3	1321778.HMPREF1982_03366	6.976e-127	409.0	COG1116@1|root,COG1116@2|Bacteria,1TT4F@1239|Firmicutes,24FTR@186801|Clostridia	186801|Clostridia	P	ABC-type nitrate sulfonate bicarbonate transport system ATPase component	-	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
HKD2_k127_1404705_6	1294142.CINTURNW_4218	1.314e-102	339.0	COG0600@1|root,COG0600@2|Bacteria,1V3NA@1239|Firmicutes,24G03@186801|Clostridia,36DRJ@31979|Clostridiaceae	186801|Clostridia	P	ABC-type nitrate sulfonate bicarbonate transport system, permease component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
HKD2_k127_1404705_0	1294142.CINTURNW_4223	2.83e-306	949.0	COG0826@1|root,COG0826@2|Bacteria,1TS0G@1239|Firmicutes,24BQV@186801|Clostridia,36G96@31979|Clostridiaceae	186801|Clostridia	O	Peptidase family U32	-	-	-	ko:K08303	ko05120,map05120	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_U32
HKD2_k127_1404705_2	649639.Bcell_2834	4.799e-199	627.0	COG0160@1|root,COG0160@2|Bacteria,1VS6F@1239|Firmicutes,4H9M7@91061|Bacilli,1ZAZ9@1386|Bacillus	91061|Bacilli	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	gabT	GO:0003674,GO:0003824,GO:0003867,GO:0008483,GO:0016740,GO:0016769	2.6.1.19,2.6.1.22,4.1.1.64	ko:K00596,ko:K00823,ko:K07250	ko00250,ko00280,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00280,map00410,map00640,map00650,map01100,map01120	M00027	R00908,R01648,R04188	RC00006,RC00062,RC00160	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
HKD2_k127_1404705_9	1499689.CCNN01000015_gene3350	1.744e-44	167.0	2DN8M@1|root,32W40@2|Bacteria,1UPVD@1239|Firmicutes,24NS7@186801|Clostridia	186801|Clostridia	S	YcxB-like protein	-	-	-	-	-	-	-	-	-	-	-	-	YcxB
HKD2_k127_1404705_10	1120746.CCNL01000010_gene1441	2.175e-26	115.0	2DS28@1|root,33E72@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Cu_amine_oxidN1
HKD2_k127_1404705_11	1321778.HMPREF1982_01902	9.893e-16	78.0	COG0406@1|root,COG0406@2|Bacteria,1UZRH@1239|Firmicutes,24E6Z@186801|Clostridia,267MU@186813|unclassified Clostridiales	186801|Clostridia	G	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,His_Phos_1
HKD2_k127_1405826_6	1121289.JHVL01000010_gene1340	1.519e-91	304.0	COG4448@1|root,COG4448@2|Bacteria,1TRWI@1239|Firmicutes,24CUE@186801|Clostridia,36GGQ@31979|Clostridiaceae	186801|Clostridia	E	L-asparaginase II	-	-	-	-	-	-	-	-	-	-	-	-	Asparaginase_II
HKD2_k127_1405826_5	1286171.EAL2_c21370	6.858e-118	397.0	COG1376@1|root,COG1376@2|Bacteria,1UAYK@1239|Firmicutes,248GN@186801|Clostridia	186801|Clostridia	S	L,D-transpeptidase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	SH3_3,YkuD
HKD2_k127_1405826_9	1230342.CTM_00285	6.838e-06	59.0	COG2247@1|root,COG3409@1|root,COG5632@1|root,COG2247@2|Bacteria,COG3409@2|Bacteria,COG5632@2|Bacteria,1V7KT@1239|Firmicutes,24G8M@186801|Clostridia,36V9U@31979|Clostridiaceae	186801|Clostridia	M	Ami_2	ampD	-	3.5.1.28	ko:K01447	-	-	R04112	RC00064,RC00141	ko00000,ko01000	-	-	-	Amidase_2,Cu_amine_oxidN1,DUF4214,Glucosaminidase,PG_binding_1,SH3_3
HKD2_k127_1405826_4	293826.Amet_2952	3.558e-156	504.0	COG0513@1|root,COG0513@2|Bacteria,1TPAP@1239|Firmicutes,247IT@186801|Clostridia,36EGF@31979|Clostridiaceae	186801|Clostridia	L	DEAD-box RNA helicase involved in the assembly of the 50S ribosomal subunit. Has an RNA-dependent ATPase activity, which is specific for 23S rRNA, and a 3' to 5' RNA helicase activity that uses the energy of ATP hydrolysis to destabilize and unwind short rRNA duplexes	rhlE	-	3.6.4.13	ko:K11927	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DEAD,Helicase_C
HKD2_k127_1405826_1	1321778.HMPREF1982_04656	2.086e-278	865.0	COG1164@1|root,COG1164@2|Bacteria,1TPV4@1239|Firmicutes,2495D@186801|Clostridia,268FJ@186813|unclassified Clostridiales	186801|Clostridia	E	oligoendopeptidase, M3 family	pz-A	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M3
HKD2_k127_1405826_2	1321778.HMPREF1982_00026	4.831e-224	699.0	COG2235@1|root,COG2235@2|Bacteria,1TQWS@1239|Firmicutes,249V9@186801|Clostridia,26C2W@186813|unclassified Clostridiales	186801|Clostridia	E	Psort location Cytoplasmic, score 7.50	arcA	-	3.5.3.6	ko:K01478	ko00220,ko01100,ko01110,ko01130,map00220,map01100,map01110,map01130	-	R00552	RC00177	ko00000,ko00001,ko01000	-	-	-	Amidinotransf
HKD2_k127_1405826_3	386415.NT01CX_0284	6.729e-201	631.0	COG0436@1|root,COG0436@2|Bacteria,1TP36@1239|Firmicutes,248ZV@186801|Clostridia,36F6N@31979|Clostridiaceae	186801|Clostridia	E	PFAM aminotransferase class I and II	yhdR	-	2.6.1.1	ko:K11358	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
HKD2_k127_1405826_7	545243.BAEV01000001_gene3166	2.192e-68	235.0	COG1522@1|root,COG1522@2|Bacteria,1V3MI@1239|Firmicutes,24I1I@186801|Clostridia,36FGM@31979|Clostridiaceae	186801|Clostridia	K	AsnC family	-	-	-	ko:K03719	-	-	-	-	ko00000,ko03000,ko03036	-	-	-	AsnC_trans_reg,HTH_24
HKD2_k127_1405826_0	767817.Desgi_0579	5.138e-286	904.0	COG2304@1|root,COG2304@2|Bacteria	2|Bacteria	IU	oxidoreductase activity	yabS	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VIT,VWA,VWA_2
HKD2_k127_1405826_8	767817.Desgi_0580	1.106e-46	174.0	2EBU8@1|root,335TU@2|Bacteria,1VVAX@1239|Firmicutes,24VTW@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Exosortase_EpsH
HKD2_k127_1408328_0	1476973.JMMB01000007_gene2948	0.0	1186.0	COG0493@1|root,COG1145@1|root,COG0493@2|Bacteria,COG1145@2|Bacteria,1TQ1A@1239|Firmicutes,248EK@186801|Clostridia,25T3S@186804|Peptostreptococcaceae	186801|Clostridia	CE	Thi4 family	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_20,Pyr_redox_2
HKD2_k127_1408328_2	1230342.CTM_06801	1.889e-125	403.0	COG0378@1|root,COG0378@2|Bacteria,1TS00@1239|Firmicutes,248T1@186801|Clostridia,36E69@31979|Clostridiaceae	186801|Clostridia	KO	Hydrogenase accessory protein HypB	hypB	-	-	ko:K04652	-	-	-	-	ko00000,ko03110	-	-	-	cobW
HKD2_k127_1408328_1	1321778.HMPREF1982_02777	7.036e-212	659.0	28H6R@1|root,2Z7J3@2|Bacteria,1TQ2I@1239|Firmicutes,247QF@186801|Clostridia	186801|Clostridia	S	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1408328_6	1321778.HMPREF1982_02776	5.687e-93	308.0	COG1309@1|root,COG1309@2|Bacteria,1UYIP@1239|Firmicutes,249K5@186801|Clostridia,26906@186813|unclassified Clostridiales	186801|Clostridia	K	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_8,TetR_N
HKD2_k127_1408328_5	1410653.JHVC01000007_gene573	2.634e-98	325.0	COG1335@1|root,COG1335@2|Bacteria,1V371@1239|Firmicutes,248KG@186801|Clostridia,36GNG@31979|Clostridiaceae	186801|Clostridia	Q	Isochorismatase family	-	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
HKD2_k127_1408328_4	469381.Dpep_0470	4.465e-118	393.0	COG0477@1|root,COG2814@2|Bacteria	2|Bacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD2_k127_1408328_3	1321778.HMPREF1982_01463	3.32e-119	386.0	COG0577@1|root,COG1511@1|root,COG0577@2|Bacteria,COG1511@2|Bacteria,1TPHU@1239|Firmicutes,248RV@186801|Clostridia,269CN@186813|unclassified Clostridiales	186801|Clostridia	V	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HKD2_k127_1410986_3	1294142.CINTURNW_2487	1.672e-75	267.0	COG0642@1|root,COG2205@2|Bacteria,1TQMV@1239|Firmicutes,247SE@186801|Clostridia,36HR5@31979|Clostridiaceae	186801|Clostridia	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_9,PocR,dCache_1
HKD2_k127_1410986_6	536227.CcarbDRAFT_2679	1.033e-61	216.0	COG5545@1|root,COG5545@2|Bacteria,1TQNX@1239|Firmicutes,2495S@186801|Clostridia,36EHX@31979|Clostridiaceae	186801|Clostridia	S	virulence-associated E family protein	-	-	-	-	-	-	-	-	-	-	-	-	VirE
HKD2_k127_1410986_4	536227.CcarbDRAFT_2679	4.47e-69	237.0	COG5545@1|root,COG5545@2|Bacteria,1TQNX@1239|Firmicutes,2495S@186801|Clostridia,36EHX@31979|Clostridiaceae	186801|Clostridia	S	virulence-associated E family protein	-	-	-	-	-	-	-	-	-	-	-	-	VirE
HKD2_k127_1410986_5	406124.ACPC01000046_gene2421	5.906e-62	221.0	29STA@1|root,30DZA@2|Bacteria,1UBXA@1239|Firmicutes,4IND1@91061|Bacilli,1ZNA9@1386|Bacillus	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1410986_8	1321778.HMPREF1982_03388	7.995e-25	106.0	2CA9A@1|root,2ZUBD@2|Bacteria,1W6S8@1239|Firmicutes,24NYS@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1410986_7	1321778.HMPREF1982_03387	3.817e-36	141.0	29UBB@1|root,2ZS8E@2|Bacteria,1W5CZ@1239|Firmicutes,24TNJ@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1410986_0	1294142.CINTURNW_1719	4.222e-202	638.0	COG2239@1|root,COG2239@2|Bacteria,1TP4V@1239|Firmicutes,2481R@186801|Clostridia,36E39@31979|Clostridiaceae	186801|Clostridia	P	Acts as a magnesium transporter	mgtE	-	-	ko:K06213	-	-	-	-	ko00000,ko02000	1.A.26.1	-	-	CBS,MgtE,MgtE_N
HKD2_k127_1410986_1	632245.CLP_0083	1.115e-150	481.0	2DBFK@1|root,2Z8Z7@2|Bacteria,1TQKG@1239|Firmicutes,2482J@186801|Clostridia,36KWP@31979|Clostridiaceae	186801|Clostridia	S	Protein of unknown function (DUF3298)	rsiV	-	-	-	-	-	-	-	-	-	-	-	DUF3298,DUF4163
HKD2_k127_1410986_2	203119.Cthe_1438	4.108e-76	258.0	COG1595@1|root,COG1595@2|Bacteria,1V734@1239|Firmicutes,24MQB@186801|Clostridia,3WQDI@541000|Ruminococcaceae	186801|Clostridia	K	Sigma-70, region 4	sigV	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD2_k127_1435707_1	203119.Cthe_0806	1.758e-43	171.0	COG5002@1|root,COG5002@2|Bacteria,1VRP7@1239|Firmicutes,24YHW@186801|Clostridia,3WGBY@541000|Ruminococcaceae	186801|Clostridia	T	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
HKD2_k127_1435707_0	865861.AZSU01000002_gene2464	7.445e-158	527.0	COG5001@1|root,COG5001@2|Bacteria,1TP8V@1239|Firmicutes,247PX@186801|Clostridia,36E1W@31979|Clostridiaceae	186801|Clostridia	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	ABC_sub_bind,EAL,GGDEF,HisKA_7TM,PAS_9,SBP_bac_3
HKD2_k127_1453301_0	293826.Amet_1726	2.312e-102	342.0	COG0280@1|root,COG0280@2|Bacteria,1TRQU@1239|Firmicutes,24857@186801|Clostridia,36DC6@31979|Clostridiaceae	186801|Clostridia	C	phosphate butyryltransferase	ptb1	-	2.3.1.19	ko:K00634	ko00650,ko01100,map00650,map01100	-	R01174	RC00004,RC02816	ko00000,ko00001,ko01000	-	-	-	PTA_PTB
HKD2_k127_1453301_2	1408422.JHYF01000002_gene2200	2.208e-65	229.0	COG1139@1|root,COG1139@2|Bacteria,1TP90@1239|Firmicutes,249B6@186801|Clostridia,36FNS@31979|Clostridiaceae	186801|Clostridia	C	LUD domain	-	-	-	-	-	-	-	-	-	-	-	-	LUD_dom
HKD2_k127_1453301_1	1211817.CCAT010000043_gene3525	4.391e-88	293.0	COG0174@1|root,COG0174@2|Bacteria,1TNZA@1239|Firmicutes,2489S@186801|Clostridia,36DYK@31979|Clostridiaceae	186801|Clostridia	E	glutamine synthetase	-	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
HKD2_k127_1453889_1	1094508.Tsac_1538	3.903e-48	182.0	COG4942@1|root,COG4942@2|Bacteria,1VJ3D@1239|Firmicutes,25ERZ@186801|Clostridia,42JGR@68295|Thermoanaerobacterales	186801|Clostridia	D	PFAM Peptidase M23	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
HKD2_k127_1453889_2	1230342.CTM_13410	4.703e-21	98.0	COG1664@1|root,COG1664@2|Bacteria,1VEVU@1239|Firmicutes,24QT5@186801|Clostridia,36MUM@31979|Clostridiaceae	186801|Clostridia	M	Polymer-forming cytoskeletal	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
HKD2_k127_1453889_0	293826.Amet_3397	1.517e-220	691.0	COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1TQ0B@1239|Firmicutes,248IB@186801|Clostridia,36DW6@31979|Clostridiaceae	186801|Clostridia	E	Glutamate synthase	gltB	-	1.4.1.13,1.4.1.14,1.4.7.1	ko:K00265,ko:K00284	ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230	-	R00021,R00093,R00114,R00248,R10086	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
HKD2_k127_1469475_6	1507.HMPREF0262_02548	2.352e-60	219.0	COG0258@1|root,COG0258@2|Bacteria,1VRDB@1239|Firmicutes,24EYZ@186801|Clostridia,36S9S@31979|Clostridiaceae	186801|Clostridia	L	5'-3' exonuclease, SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	5_3_exonuc,5_3_exonuc_N
HKD2_k127_1469475_2	332101.JIBU02000013_gene1373	5.517e-94	312.0	COG2872@1|root,COG2872@2|Bacteria,1V2RR@1239|Firmicutes,25CM7@186801|Clostridia	186801|Clostridia	S	Threonyl and Alanyl tRNA synthetase second additional domain	-	-	-	-	-	-	-	-	-	-	-	-	tRNA_SAD
HKD2_k127_1469475_5	1399115.U719_09025	9.827e-78	266.0	COG1131@1|root,COG1131@2|Bacteria,1TQKM@1239|Firmicutes,4HBUK@91061|Bacilli,3WE6B@539002|Bacillales incertae sedis	91061|Bacilli	V	AAA domain, putative AbiEii toxin, Type IV TA system	ybhF_2	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD2_k127_1469475_4	931626.Awo_c16030	6.923e-91	310.0	COG0842@1|root,COG0842@2|Bacteria,1TQG7@1239|Firmicutes,249TT@186801|Clostridia,25XMH@186806|Eubacteriaceae	186801|Clostridia	U	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane,ABC2_membrane_3
HKD2_k127_1469475_1	588581.Cpap_2264	5.405e-96	323.0	COG2207@1|root,COG3708@1|root,COG2207@2|Bacteria,COG3708@2|Bacteria,1TPI9@1239|Firmicutes,2496K@186801|Clostridia,3WIIB@541000|Ruminococcaceae	186801|Clostridia	K	transcription activator, effector binding	-	-	-	ko:K13653	-	-	-	-	ko00000,ko03000	-	-	-	Cass2,GyrI-like,HTH_18
HKD2_k127_1469475_9	1265505.ATUG01000001_gene3422	3.225e-22	100.0	2DMZP@1|root,32UMQ@2|Bacteria,1N3K9@1224|Proteobacteria,42UFA@68525|delta/epsilon subdivisions,2WQ9Z@28221|Deltaproteobacteria,2MNTS@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF3795)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3795
HKD2_k127_1469475_7	871968.DESME_02170	9.086e-57	203.0	COG3981@1|root,COG3981@2|Bacteria,1VIYZ@1239|Firmicutes,25B9Y@186801|Clostridia	186801|Clostridia	S	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
HKD2_k127_1469475_3	588581.Cpap_2264	4.52e-91	308.0	COG2207@1|root,COG3708@1|root,COG2207@2|Bacteria,COG3708@2|Bacteria,1TPI9@1239|Firmicutes,2496K@186801|Clostridia,3WIIB@541000|Ruminococcaceae	186801|Clostridia	K	transcription activator, effector binding	-	-	-	ko:K13653	-	-	-	-	ko00000,ko03000	-	-	-	Cass2,GyrI-like,HTH_18
HKD2_k127_1469475_0	1031288.AXAA01000015_gene286	4.207e-190	597.0	COG0115@1|root,COG0115@2|Bacteria,1TQQI@1239|Firmicutes,2480D@186801|Clostridia,36E7V@31979|Clostridiaceae	186801|Clostridia	E	Branched-chain amino acid aminotransferase	ilvE	-	2.6.1.42,4.1.3.38	ko:K00826,ko:K02619	ko00270,ko00280,ko00290,ko00770,ko00790,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map00790,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R05553,R10991	RC00006,RC00036,RC01843,RC02148	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
HKD2_k127_1469475_8	349161.Dred_1419	5.802e-31	132.0	COG1284@1|root,COG1284@2|Bacteria,1TRAU@1239|Firmicutes,249DE@186801|Clostridia,264HU@186807|Peptococcaceae	186801|Clostridia	S	protein conserved in bacteria (DUF2179)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2179,YitT_membrane
HKD2_k127_1474168_2	913865.DOT_0732	1.052e-97	322.0	COG1136@1|root,COG1136@2|Bacteria,1TPBJ@1239|Firmicutes,248EZ@186801|Clostridia,2618D@186807|Peptococcaceae	186801|Clostridia	V	ABC-type antimicrobial peptide transport system, ATPase component	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD2_k127_1474168_0	913865.DOT_0733	8.688e-162	517.0	COG0577@1|root,COG0577@2|Bacteria,1TPUU@1239|Firmicutes,2483J@186801|Clostridia,261BU@186807|Peptococcaceae	186801|Clostridia	V	ABC-type transport system involved in lipoprotein release permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HKD2_k127_1474168_1	44251.PDUR_14660	1.219e-104	343.0	COG0745@1|root,COG0745@2|Bacteria,1TSWT@1239|Firmicutes,4HGB5@91061|Bacilli,26RSX@186822|Paenibacillaceae	91061|Bacilli	T	Heme response regulator HssR	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
HKD2_k127_1474168_3	931626.Awo_c02620	2.645e-10	68.0	COG0642@1|root,COG3850@1|root,COG2205@2|Bacteria,COG3850@2|Bacteria,1V10X@1239|Firmicutes,249HQ@186801|Clostridia,25ZX5@186806|Eubacteriaceae	186801|Clostridia	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
HKD2_k127_1481596_2	1033810.HLPCO_001871	7.984e-231	729.0	COG0514@1|root,COG0514@2|Bacteria,2NNZU@2323|unclassified Bacteria	2|Bacteria	L	ATP-dependent DNA helicase RecQ	recQ	-	3.6.4.12	ko:K03654	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,HRDC,HTH_40,Helicase_C,RQC,RecQ_Zn_bind
HKD2_k127_1481596_9	324057.Pjdr2_1142	3.04e-75	258.0	COG4193@1|root,COG4193@2|Bacteria,1UJEJ@1239|Firmicutes,4IT72@91061|Bacilli,2778R@186822|Paenibacillaceae	91061|Bacilli	G	S-layer homology domain	-	-	-	-	-	-	-	-	-	-	-	-	SLH
HKD2_k127_1481596_0	1410653.JHVC01000003_gene3947	7.596e-308	963.0	COG0457@1|root,COG5263@1|root,COG5513@1|root,COG0457@2|Bacteria,COG5263@2|Bacteria,COG5513@2|Bacteria,1TSIS@1239|Firmicutes,25EBW@186801|Clostridia,36UJT@31979|Clostridiaceae	186801|Clostridia	KLT	Protein of unknown function (DUF3298)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3298,WG_beta_rep
HKD2_k127_1481596_4	1321778.HMPREF1982_00728	3.625e-154	499.0	COG0534@1|root,COG0534@2|Bacteria,1TQMT@1239|Firmicutes,249WJ@186801|Clostridia	186801|Clostridia	V	Mate efflux family protein	-	-	-	-	-	-	-	-	-	-	-	-	MatE
HKD2_k127_1481596_5	1449126.JQKL01000001_gene1463	1.222e-148	505.0	COG3290@1|root,COG3437@1|root,COG3290@2|Bacteria,COG3437@2|Bacteria,1TQ0S@1239|Firmicutes,24800@186801|Clostridia,26AR3@186813|unclassified Clostridiales	186801|Clostridia	T	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,HD_5,PAS,PAS_4,PAS_9
HKD2_k127_1481596_8	86416.Clopa_4078	1.041e-80	273.0	COG0515@1|root,COG0515@2|Bacteria,1VBSJ@1239|Firmicutes,24G8C@186801|Clostridia,36I95@31979|Clostridiaceae	186801|Clostridia	KLT	COG0515 Serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1481596_3	642492.Clole_2003	6.165e-182	576.0	COG1883@1|root,COG1883@2|Bacteria,1TPEP@1239|Firmicutes,248ET@186801|Clostridia	186801|Clostridia	C	decarboxylase beta subunit	-	-	4.1.1.3	ko:K01572	ko00620,ko01100,map00620,map01100	-	R00217	RC00040	ko00000,ko00001,ko01000,ko02000	3.B.1.1.1	-	-	OAD_beta
HKD2_k127_1481596_6	642492.Clole_2000	1.685e-92	312.0	COG0583@1|root,COG0583@2|Bacteria,1TP6T@1239|Firmicutes,24970@186801|Clostridia	186801|Clostridia	K	transcriptional regulator	-	-	-	ko:K21900	-	-	-	-	ko00000,ko03000	-	-	-	HTH_1,LysR_substrate
HKD2_k127_1481596_7	293826.Amet_1000	4.443e-81	277.0	COG1526@1|root,COG1526@2|Bacteria,1TU8R@1239|Firmicutes,24G61@186801|Clostridia,36HJU@31979|Clostridiaceae	186801|Clostridia	C	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH	fdhD	-	-	ko:K02379	-	-	-	-	ko00000	-	-	-	FdhD-NarQ
HKD2_k127_1481596_1	1286171.EAL2_c04340	3.386e-234	735.0	COG3383@1|root,COG3383@2|Bacteria,1UI1F@1239|Firmicutes,25EAG@186801|Clostridia,25VUD@186806|Eubacteriaceae	186801|Clostridia	C	Molybdopterin oxidoreductase Fe4S4 domain	fdhA2	-	1.17.1.11,1.17.1.9	ko:K00123,ko:K22341	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Fer2_4,Fer4,Fer4_6,Fer4_7,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
HKD2_k127_1483656_0	580327.Tthe_1093	8.126e-138	464.0	COG3858@1|root,COG3858@2|Bacteria,1UJQT@1239|Firmicutes,25GCV@186801|Clostridia,42F1W@68295|Thermoanaerobacterales	186801|Clostridia	S	Propeptide, PepSY	-	-	-	-	-	-	-	-	-	-	-	-	PepSY,SLH
HKD2_k127_1483656_1	1321778.HMPREF1982_00917	2.347e-107	352.0	COG1187@1|root,COG1187@2|Bacteria,1TP68@1239|Firmicutes,248UG@186801|Clostridia	186801|Clostridia	J	Belongs to the pseudouridine synthase RsuA family	rluF	-	5.4.99.21,5.4.99.22	ko:K06178,ko:K06182	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
HKD2_k127_1483656_3	555088.DealDRAFT_2731	2.616e-52	190.0	COG1633@1|root,COG1633@2|Bacteria,1V72Y@1239|Firmicutes,24JY4@186801|Clostridia	186801|Clostridia	M	Coat F domain	-	-	-	-	-	-	-	-	-	-	-	-	Coat_F,Rubrerythrin
HKD2_k127_1483656_4	1540257.JQMW01000011_gene2209	1.745e-35	143.0	COG4720@1|root,COG4720@2|Bacteria,1V1E7@1239|Firmicutes,25CJR@186801|Clostridia,36WX9@31979|Clostridiaceae	186801|Clostridia	S	ECF-type riboflavin transporter, S component	-	-	-	-	-	-	-	-	-	-	-	-	ECF-ribofla_trS
HKD2_k127_1483656_5	335541.Swol_1963	9.048e-22	111.0	COG2041@1|root,COG2041@2|Bacteria	2|Bacteria	V	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide	-	-	-	-	-	-	-	-	-	-	-	-	CHB_HEX_C_1,Fn3_assoc,Oxidored_molyb,SLH
HKD2_k127_1483656_2	1121335.Clst_2367	1.449e-93	332.0	COG3858@1|root,COG3858@2|Bacteria,1TQK2@1239|Firmicutes,247YF@186801|Clostridia,3WIAH@541000|Ruminococcaceae	186801|Clostridia	M	Glycosyl hydrolase	ydhD	-	-	-	-	-	-	-	-	-	-	-	CW_binding_2,Cu_amine_oxidN1,Glyco_hydro_18,SH3_3
HKD2_k127_1483668_1	1408422.JHYF01000004_gene1665	9.51e-145	469.0	COG2203@1|root,COG3437@1|root,COG2203@2|Bacteria,COG3437@2|Bacteria,1TQ0S@1239|Firmicutes,24800@186801|Clostridia,36E1T@31979|Clostridiaceae	186801|Clostridia	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	DUF3369,GGDEF,HD,PAS,Response_reg
HKD2_k127_1483668_0	1408422.JHYF01000004_gene1664	6.008e-261	811.0	COG1541@1|root,COG1541@2|Bacteria,1UPIS@1239|Firmicutes,25HHC@186801|Clostridia	186801|Clostridia	H	GH3 auxin-responsive promoter	-	-	-	-	-	-	-	-	-	-	-	-	GH3
HKD2_k127_1483668_2	1408422.JHYF01000004_gene1663	2.609e-77	264.0	COG2020@1|root,COG2020@2|Bacteria,1VC4U@1239|Firmicutes,24PVH@186801|Clostridia	186801|Clostridia	O	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
HKD2_k127_1497327_0	1195236.CTER_0820	1.612e-207	651.0	COG0443@1|root,COG0443@2|Bacteria,1TP1J@1239|Firmicutes,248QV@186801|Clostridia,3WGES@541000|Ruminococcaceae	186801|Clostridia	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
HKD2_k127_1497327_2	1304284.L21TH_1367	2.044e-148	478.0	COG0484@1|root,COG0484@2|Bacteria,1TP00@1239|Firmicutes,248EM@186801|Clostridia,36E5A@31979|Clostridiaceae	186801|Clostridia	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	-	-	ko:K03686,ko:K05516	-	-	-	-	ko00000,ko03029,ko03036,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
HKD2_k127_1497327_4	350688.Clos_1235	1.063e-102	345.0	COG2264@1|root,COG2264@2|Bacteria,1TPKI@1239|Firmicutes,247VY@186801|Clostridia,36FBU@31979|Clostridiaceae	186801|Clostridia	J	Ribosomal protein L11 methyltransferase	prmA	-	-	ko:K02687	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PrmA
HKD2_k127_1497327_5	398512.JQKC01000012_gene189	5.535e-73	254.0	COG1385@1|root,COG1385@2|Bacteria,1V1CT@1239|Firmicutes,249VK@186801|Clostridia,3WIFN@541000|Ruminococcaceae	186801|Clostridia	J	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit	rsmE	-	2.1.1.193	ko:K09761	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_RNA
HKD2_k127_1497327_1	509191.AEDB02000103_gene3747	3.578e-167	536.0	COG0621@1|root,COG0621@2|Bacteria,1TPBR@1239|Firmicutes,247IX@186801|Clostridia,3WG80@541000|Ruminococcaceae	186801|Clostridia	J	tRNA methylthiotransferase YqeV	yqeV	-	2.8.4.5	ko:K18707	-	-	R10649	RC00003,RC03221	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
HKD2_k127_1497327_7	1211817.CCAT010000003_gene298	7.273e-43	159.0	COG0537@1|root,COG0537@2|Bacteria,1V9ZJ@1239|Firmicutes,24JCW@186801|Clostridia,36JIP@31979|Clostridiaceae	186801|Clostridia	FG	Hit family	hinT	-	-	ko:K02503	-	-	-	-	ko00000,ko04147	-	-	-	HIT
HKD2_k127_1497327_9	1410653.JHVC01000009_gene2834	8.778e-23	98.0	COG0828@1|root,COG0828@2|Bacteria,1VEHU@1239|Firmicutes,24QP9@186801|Clostridia,36MKD@31979|Clostridiaceae	186801|Clostridia	J	Belongs to the bacterial ribosomal protein bS21 family	rpsU	-	-	ko:K02970	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S21
HKD2_k127_1497327_6	720554.Clocl_2789	3.482e-49	179.0	COG1610@1|root,COG1610@2|Bacteria,1V6F2@1239|Firmicutes,24JB0@186801|Clostridia,3WK1B@541000|Ruminococcaceae	186801|Clostridia	S	Yqey-like protein	yqeY	-	-	ko:K09117	-	-	-	-	ko00000	-	-	-	YqeY
HKD2_k127_1497327_8	1121289.JHVL01000002_gene2347	1.886e-31	129.0	COG1030@1|root,COG1030@2|Bacteria,1TR54@1239|Firmicutes,247N5@186801|Clostridia,36F6E@31979|Clostridiaceae	186801|Clostridia	O	NfeD-like C-terminal, partner-binding	yqeZ	-	-	ko:K07403	-	-	-	-	ko00000	-	-	-	CLP_protease,NfeD,SDH_sah
HKD2_k127_1497327_3	138119.DSY1747	4.377e-141	452.0	COG4864@1|root,COG4864@2|Bacteria,1TPTD@1239|Firmicutes,24APU@186801|Clostridia,260UQ@186807|Peptococcaceae	186801|Clostridia	S	UPF0365 protein	-	-	-	-	-	-	-	-	-	-	-	-	YdfA_immunity
HKD2_k127_1506997_0	1540257.JQMW01000011_gene2208	2.221e-174	554.0	COG0075@1|root,COG0075@2|Bacteria,1TPS0@1239|Firmicutes,24919@186801|Clostridia,36E72@31979|Clostridiaceae	186801|Clostridia	E	Aminotransferase	-	-	2.6.1.44,2.6.1.45,2.6.1.51	ko:K00830	ko00250,ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko04146,map00250,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200,map04146	M00346,M00532	R00369,R00372,R00585,R00588	RC00006,RC00008,RC00018	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_5
HKD2_k127_1506997_7	272563.CD630_25310	1.131e-62	220.0	COG4720@1|root,COG4720@2|Bacteria,1V1E7@1239|Firmicutes,25CJR@186801|Clostridia,25TW0@186804|Peptostreptococcaceae	186801|Clostridia	S	ECF-type riboflavin transporter, S component	-	-	-	-	-	-	-	-	-	-	-	-	ECF-ribofla_trS
HKD2_k127_1506997_10	273068.TTE0639	7.588e-54	201.0	COG0697@1|root,COG0697@2|Bacteria,1TPUW@1239|Firmicutes,247X1@186801|Clostridia,42FMV@68295|Thermoanaerobacterales	186801|Clostridia	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HKD2_k127_1506997_11	1408422.JHYF01000010_gene3343	2.023e-47	175.0	COG4843@1|root,COG4843@2|Bacteria,1V14J@1239|Firmicutes,24J7S@186801|Clostridia,36IGD@31979|Clostridiaceae	186801|Clostridia	S	Uncharacterized protein conserved in bacteria (DUF2179)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2179
HKD2_k127_1506997_12	1121335.Clst_2289	1.022e-44	175.0	COG2340@1|root,COG2340@2|Bacteria,1V6GZ@1239|Firmicutes,24BAQ@186801|Clostridia,3WJQ5@541000|Ruminococcaceae	186801|Clostridia	M	Cysteine-rich secretory protein family	safA	-	-	-	-	-	-	-	-	-	-	-	CAP,LysM
HKD2_k127_1506997_13	351627.Csac_1150	1.585e-34	137.0	COG1388@1|root,COG2340@1|root,COG1388@2|Bacteria,COG2340@2|Bacteria,1V6GZ@1239|Firmicutes,24BAQ@186801|Clostridia,42J11@68295|Thermoanaerobacterales	186801|Clostridia	M	Peptidoglycan-binding LysM	safA	-	-	-	-	-	-	-	-	-	-	-	CAP,LysM
HKD2_k127_1506997_8	1235279.C772_02361	1.197e-60	216.0	COG0220@1|root,COG0220@2|Bacteria,1TQCA@1239|Firmicutes,4HC08@91061|Bacilli,26D7P@186818|Planococcaceae	91061|Bacilli	J	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA	trmB	GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008176,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0034708,GO:0036265,GO:0043170,GO:0043412,GO:0043414,GO:0043527,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0106004,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1990234	2.1.1.33	ko:K03439	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltransf_4
HKD2_k127_1506997_5	293826.Amet_1180	1.933e-70	244.0	COG0664@1|root,COG0664@2|Bacteria,1V3XW@1239|Firmicutes,24HXX@186801|Clostridia,36VUG@31979|Clostridiaceae	186801|Clostridia	K	helix_turn_helix, cAMP Regulatory protein	-	-	-	ko:K10914,ko:K21563	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
HKD2_k127_1506997_6	865861.AZSU01000006_gene1428	2.556e-70	248.0	COG0697@1|root,COG0697@2|Bacteria,1TPUW@1239|Firmicutes,247X1@186801|Clostridia,36FB9@31979|Clostridiaceae	186801|Clostridia	EG	DMT(Drug metabolite transporter) superfamily permease	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HKD2_k127_1506997_15	398512.JQKC01000009_gene416	1.856e-15	82.0	2DR5I@1|root,33A9E@2|Bacteria,1VM5P@1239|Firmicutes,24UWH@186801|Clostridia,3WME3@541000|Ruminococcaceae	186801|Clostridia	S	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	DZR,zf-ribbon_3,zinc_ribbon_2
HKD2_k127_1506997_1	935948.KE386494_gene60	2.491e-108	362.0	COG0772@1|root,COG0772@2|Bacteria,1TPGH@1239|Firmicutes,247WS@186801|Clostridia,42EMA@68295|Thermoanaerobacterales	186801|Clostridia	M	Peptidoglycan polymerase that is essential for cell wall elongation	rodA	-	-	ko:K05837	-	-	-	-	ko00000,ko03036	-	-	-	FTSW_RODA_SPOVE
HKD2_k127_1506997_16	1128398.Curi_c01280	4.318e-05	56.0	COG3087@1|root,COG3087@2|Bacteria,1V30Z@1239|Firmicutes,249SI@186801|Clostridia	186801|Clostridia	D	Cobalamin biosynthesis protein CobT VWA domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1506997_14	857293.CAAU_2415	1.243e-22	112.0	COG4547@1|root,COG4547@2|Bacteria,1V15P@1239|Firmicutes,25E6Y@186801|Clostridia,36UWZ@31979|Clostridiaceae	186801|Clostridia	H	Cobalamin biosynthesis protein CobT VWA domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1506997_2	350688.Clos_2657	8.324e-102	338.0	COG0030@1|root,COG0030@2|Bacteria,1TP9W@1239|Firmicutes,248RY@186801|Clostridia,36DEP@31979|Clostridiaceae	186801|Clostridia	J	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	-	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
HKD2_k127_1506997_9	445973.CLOBAR_02509	7.427e-59	210.0	COG1658@1|root,COG1658@2|Bacteria,1V3K3@1239|Firmicutes,24I8W@186801|Clostridia,25QDT@186804|Peptostreptococcaceae	186801|Clostridia	J	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step	rnmV	-	3.1.26.8	ko:K05985	-	-	-	-	ko00000,ko01000	-	-	-	DUF4093,Toprim,Toprim_4
HKD2_k127_1506997_4	580331.Thit_0100	5.423e-71	252.0	COG3583@1|root,COG3584@1|root,COG3583@2|Bacteria,COG3584@2|Bacteria,1TTIK@1239|Firmicutes,24997@186801|Clostridia,42ETJ@68295|Thermoanaerobacterales	186801|Clostridia	S	G5 domain protein	yabE	-	-	-	-	-	-	-	-	-	-	-	3D,DUF348,G5
HKD2_k127_1506997_3	293826.Amet_0111	3.239e-81	274.0	COG0084@1|root,COG0084@2|Bacteria,1TNY1@1239|Firmicutes,248HE@186801|Clostridia,36EDX@31979|Clostridiaceae	186801|Clostridia	L	Hydrolase, TatD family	tatD	-	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
HKD2_k127_1507036_2	1321778.HMPREF1982_00413	5.976e-94	319.0	COG0642@1|root,COG2205@2|Bacteria,1TQMV@1239|Firmicutes,247SE@186801|Clostridia,26ATW@186813|unclassified Clostridiales	186801|Clostridia	T	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_8,PAS_9
HKD2_k127_1507036_5	743719.PaelaDRAFT_4154	1.26e-53	198.0	COG1266@1|root,COG1266@2|Bacteria,1TYWG@1239|Firmicutes,4I827@91061|Bacilli,26YN3@186822|Paenibacillaceae	91061|Bacilli	S	CAAX protease self-immunity	-	-	-	-	-	-	-	-	-	-	-	-	Abi
HKD2_k127_1507036_12	1195236.CTER_3072	2.924e-13	69.0	COG2119@1|root,COG2119@2|Bacteria,1UFX2@1239|Firmicutes,24DHF@186801|Clostridia,3WJB8@541000|Ruminococcaceae	186801|Clostridia	S	Uncharacterized protein family UPF0016	-	-	-	-	-	-	-	-	-	-	-	-	UPF0016
HKD2_k127_1507036_14	58344.JOEL01000044_gene886	1.587e-05	49.0	COG2267@1|root,COG2267@2|Bacteria,2GPA8@201174|Actinobacteria	201174|Actinobacteria	I	hydrolase	-	-	3.1.1.5	ko:K01048	ko00564,map00564	-	-	-	ko00000,ko00001,ko01000	-	-	-	Hydrolase_4
HKD2_k127_1507036_11	273068.TTE1601	1.611e-20	105.0	COG0845@1|root,COG0845@2|Bacteria,1UED0@1239|Firmicutes,25J94@186801|Clostridia,42G7P@68295|Thermoanaerobacterales	186801|Clostridia	M	membrane fusion protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1507036_3	1128398.Curi_c17020	5.381e-82	279.0	COG0325@1|root,COG0325@2|Bacteria,1TRDN@1239|Firmicutes,248R6@186801|Clostridia,26909@186813|unclassified Clostridiales	186801|Clostridia	S	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis	ylmE	-	-	ko:K06997	-	-	-	-	ko00000	-	-	-	Ala_racemase_N
HKD2_k127_1507036_8	293826.Amet_2803	3.596e-35	140.0	COG1799@1|root,COG1799@2|Bacteria,1VER3@1239|Firmicutes,24I9Y@186801|Clostridia,36I3V@31979|Clostridiaceae	186801|Clostridia	D	Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA	sepF	-	-	ko:K09772	-	-	-	-	ko00000,ko03036	-	-	-	SepF
HKD2_k127_1507036_13	1286171.EAL2_c14890	7.102e-12	69.0	COG0762@1|root,COG0762@2|Bacteria	2|Bacteria	D	integral membrane protein	yggT	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K02221	-	-	-	-	ko00000,ko02044	-	-	-	YGGT
HKD2_k127_1507036_4	588581.Cpap_1578	1.549e-57	209.0	COG2302@1|root,COG2302@2|Bacteria,1U5V2@1239|Firmicutes,24GDV@186801|Clostridia,3WJ3J@541000|Ruminococcaceae	186801|Clostridia	S	S4 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	S4
HKD2_k127_1507036_6	1304284.L21TH_0644	1.286e-48	177.0	COG3599@1|root,COG3599@2|Bacteria,1V27M@1239|Firmicutes,24MM3@186801|Clostridia,36FZ8@31979|Clostridiaceae	186801|Clostridia	D	PFAM DivIVA family protein	divIVA	-	-	ko:K04074	-	-	-	-	ko00000,ko03036	-	-	-	DivIVA
HKD2_k127_1507036_1	1304284.L21TH_0646	1.19e-101	338.0	COG2876@1|root,COG2876@2|Bacteria,1TP61@1239|Firmicutes,24812@186801|Clostridia,36FA1@31979|Clostridiaceae	186801|Clostridia	E	phospho-2-dehydro-3-deoxyheptonate aldolase	aroF	-	2.5.1.54,5.4.99.5	ko:K01626,ko:K03856,ko:K13853	ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024	M00022,M00024,M00025	R01715,R01826	RC00435,RC03116	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_1
HKD2_k127_1507036_10	858215.Thexy_1464	5.133e-25	107.0	2E46D@1|root,32Z2B@2|Bacteria,1VEH0@1239|Firmicutes,24QMP@186801|Clostridia,42GX8@68295|Thermoanaerobacterales	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1507036_7	697281.Mahau_1029	3.068e-35	141.0	COG1734@1|root,COG1734@2|Bacteria,1V6MF@1239|Firmicutes,24K3N@186801|Clostridia,42FT9@68295|Thermoanaerobacterales	186801|Clostridia	K	TIGRFAM sporulation protein, yteA	-	-	-	-	-	-	-	-	-	-	-	-	zf-dskA_traR
HKD2_k127_1507036_9	1304880.JAGB01000001_gene582	1.777e-33	134.0	COG0597@1|root,COG0597@2|Bacteria,1VA9R@1239|Firmicutes,24QPP@186801|Clostridia	186801|Clostridia	MU	This protein specifically catalyzes the removal of signal peptides from prolipoproteins	lspA	-	3.4.23.36	ko:K03101	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_A8
HKD2_k127_1507036_0	857293.CAAU_1315	9.517e-127	411.0	COG0564@1|root,COG0564@2|Bacteria,1TPCM@1239|Firmicutes,247Y2@186801|Clostridia,36EAK@31979|Clostridiaceae	186801|Clostridia	J	Responsible for synthesis of pseudouridine from uracil	rluD	-	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
HKD2_k127_1513679_4	931276.Cspa_c13380	8.232e-27	111.0	COG2740@1|root,COG2740@2|Bacteria,1VEJS@1239|Firmicutes,24QSJ@186801|Clostridia,36KH1@31979|Clostridiaceae	186801|Clostridia	K	Nucleic-acid-binding protein implicated in transcription termination	ylxR	-	-	ko:K07742	-	-	-	-	ko00000	-	-	-	DUF448
HKD2_k127_1513679_5	397291.C804_05595	1.05e-25	109.0	COG1358@1|root,COG1358@2|Bacteria,1VEYG@1239|Firmicutes,24QP3@186801|Clostridia,27PF5@186928|unclassified Lachnospiraceae	186801|Clostridia	J	Ribosomal protein L7Ae/L30e/S12e/Gadd45 family	-	-	-	-	-	-	-	-	-	-	-	-	Ribosomal_L7Ae
HKD2_k127_1513679_0	857293.CAAU_1450	4.293e-256	812.0	COG0532@1|root,COG0532@2|Bacteria,1TPAI@1239|Firmicutes,248SJ@186801|Clostridia,36EJE@31979|Clostridiaceae	186801|Clostridia	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,IF-2,IF2_N
HKD2_k127_1513679_3	203119.Cthe_0990	1.049e-36	141.0	COG0858@1|root,COG0858@2|Bacteria,1VA0P@1239|Firmicutes,24MPB@186801|Clostridia,3WJ9Y@541000|Ruminococcaceae	186801|Clostridia	J	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA	rbfA	-	-	ko:K02834	-	-	-	-	ko00000,ko03009	-	-	-	RBFA
HKD2_k127_1513679_1	1195236.CTER_1071	6.918e-77	268.0	COG0618@1|root,COG0618@2|Bacteria,1TPXX@1239|Firmicutes,248R3@186801|Clostridia,3WGKS@541000|Ruminococcaceae	186801|Clostridia	S	domain protein	nrnA	-	3.1.13.3,3.1.3.7	ko:K06881	ko00920,ko01100,ko01120,map00920,map01100,map01120	-	R00188,R00508	RC00078	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
HKD2_k127_1513679_2	1121324.CLIT_11c02390	7.117e-74	261.0	COG0130@1|root,COG0130@2|Bacteria,1TP9Y@1239|Firmicutes,24B46@186801|Clostridia,25QIQ@186804|Peptostreptococcaceae	186801|Clostridia	J	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs	truB	-	5.4.99.25	ko:K03177	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruB-C_2,TruB_C_2,TruB_N
HKD2_k127_1513679_6	573061.Clocel_1792	3.921e-10	63.0	COG0196@1|root,COG0196@2|Bacteria,1TPKS@1239|Firmicutes,2484A@186801|Clostridia,36EA2@31979|Clostridiaceae	186801|Clostridia	H	Belongs to the ribF family	ribF	-	2.7.1.26,2.7.7.2	ko:K11753	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00161,R00549	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_syn,Flavokinase
HKD2_k127_1514006_2	880071.Fleli_0421	2.126e-06	54.0	COG0577@1|root,COG0577@2|Bacteria,4NEBD@976|Bacteroidetes,47KYR@768503|Cytophagia	976|Bacteroidetes	V	ABC-type antimicrobial peptide transport system, permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HKD2_k127_1514006_1	350688.Clos_1970	1.92e-17	89.0	COG3027@1|root,COG3027@2|Bacteria	2|Bacteria	D	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division	zapA	GO:0000003,GO:0000278,GO:0000281,GO:0000910,GO:0000917,GO:0000921,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006996,GO:0007010,GO:0007049,GO:0008150,GO:0009987,GO:0016043,GO:0019954,GO:0022402,GO:0022414,GO:0022607,GO:0030428,GO:0031106,GO:0032153,GO:0032185,GO:0032505,GO:0032506,GO:0034622,GO:0042802,GO:0043093,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0051301,GO:0061640,GO:0065003,GO:0070925,GO:0071840,GO:0090529,GO:1902410,GO:1903047	-	ko:K09888	-	-	-	-	ko00000,ko03036	-	-	-	ZapA
HKD2_k127_1514006_0	1304284.L21TH_1035	3.29e-139	460.0	COG0826@1|root,COG0826@2|Bacteria,1TQS1@1239|Firmicutes,24909@186801|Clostridia,36DQX@31979|Clostridiaceae	186801|Clostridia	O	peptidase U32	-	-	-	ko:K08303	ko05120,map05120	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	DUF3656,Peptidase_U32
HKD2_k127_1517719_1	1304284.L21TH_1546	3.581e-99	329.0	COG0653@1|root,COG0653@2|Bacteria,1TPEY@1239|Firmicutes,247N2@186801|Clostridia,36DNR@31979|Clostridiaceae	186801|Clostridia	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	-	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	Helicase_C,SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
HKD2_k127_1517719_0	1304284.L21TH_1547	1.661e-146	471.0	COG1186@1|root,COG1186@2|Bacteria,1TPSB@1239|Firmicutes,247KU@186801|Clostridia,36DUM@31979|Clostridiaceae	186801|Clostridia	J	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA	prfB	-	-	ko:K02836	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
HKD2_k127_1517719_2	1304284.L21TH_1548	1.111e-65	246.0	COG0840@1|root,COG0840@2|Bacteria,1TP5A@1239|Firmicutes,247S3@186801|Clostridia,36H8Y@31979|Clostridiaceae	186801|Clostridia	NT	PFAM histidine kinase, HAMP region domain protein	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	HAMP,MCPsignal,dCache_1,dCache_2,sCache_3_3
HKD2_k127_1521375_0	857293.CAAU_1274	1.531e-161	522.0	COG0769@1|root,COG0769@2|Bacteria,1TPQE@1239|Firmicutes,248Q4@186801|Clostridia,36DF8@31979|Clostridiaceae	186801|Clostridia	M	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan	murE	-	6.3.2.13	ko:K01928	ko00300,ko00550,map00300,map00550	-	R02788	RC00064,RC00090	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
HKD2_k127_1521375_2	580331.Thit_1486	2.166e-127	422.0	COG0770@1|root,COG0770@2|Bacteria,1VT78@1239|Firmicutes,25100@186801|Clostridia,42EWR@68295|Thermoanaerobacterales	186801|Clostridia	M	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein	murF	-	6.3.2.10	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	-	R04573,R04617	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
HKD2_k127_1521375_5	865861.AZSU01000003_gene1942	1.07e-97	329.0	COG0472@1|root,COG0472@2|Bacteria,1TP8W@1239|Firmicutes,247S7@186801|Clostridia,36DPY@31979|Clostridiaceae	186801|Clostridia	M	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan	mraY	-	2.7.8.13	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	-	R05629,R05630	RC00002,RC02753	ko00000,ko00001,ko01000,ko01011	9.B.146	-	-	Glycos_transf_4,MraY_sig1
HKD2_k127_1521375_1	1408422.JHYF01000002_gene2523	7.745e-152	494.0	COG0771@1|root,COG0771@2|Bacteria,1TQ3P@1239|Firmicutes,248GS@186801|Clostridia,36DUY@31979|Clostridiaceae	186801|Clostridia	M	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)	murD	-	6.3.2.9	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R02783	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase_C,Mur_ligase_M
HKD2_k127_1521375_4	1121335.Clst_2083	1.13e-108	362.0	COG0772@1|root,COG0772@2|Bacteria,1TPT7@1239|Firmicutes,24894@186801|Clostridia,3WHWW@541000|Ruminococcaceae	186801|Clostridia	D	Belongs to the SEDS family	ftsW	-	-	ko:K03588	ko04112,map04112	-	-	-	ko00000,ko00001,ko02000,ko03036	2.A.103.1	-	-	FTSW_RODA_SPOVE
HKD2_k127_1521375_3	1304284.L21TH_0615	3.081e-122	402.0	COG0707@1|root,COG0707@2|Bacteria,1TQFT@1239|Firmicutes,248IA@186801|Clostridia,36E84@31979|Clostridiaceae	186801|Clostridia	M	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)	murG	-	2.4.1.227	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	-	R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011	-	GT28	-	Glyco_tran_28_C,Glyco_transf_28
HKD2_k127_1521375_6	293826.Amet_2878	2.716e-27	114.0	COG0766@1|root,COG0766@2|Bacteria,1TPAU@1239|Firmicutes,2488W@186801|Clostridia,36DC0@31979|Clostridiaceae	186801|Clostridia	M	Belongs to the EPSP synthase family. MurA subfamily	murA2	-	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase
HKD2_k127_1527639_4	720554.Clocl_1750	2.067e-47	184.0	2DMEN@1|root,32R0Q@2|Bacteria,1V71M@1239|Firmicutes,24KBN@186801|Clostridia,3WJR1@541000|Ruminococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	TadE
HKD2_k127_1527639_5	545696.HOLDEFILI_01952	6.864e-09	63.0	COG1989@1|root,COG1989@2|Bacteria,1V91J@1239|Firmicutes,3VUQK@526524|Erysipelotrichia	526524|Erysipelotrichia	NOU	Bacterial Peptidase A24 N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	DiS_P_DiS,Peptidase_A24
HKD2_k127_1527639_3	203119.Cthe_1334	2.676e-55	211.0	COG1716@1|root,COG1716@2|Bacteria,1V8BK@1239|Firmicutes,24M8Z@186801|Clostridia,3WMJ3@541000|Ruminococcaceae	186801|Clostridia	T	Forkhead associated domain	-	-	-	-	-	-	-	-	-	-	-	-	FHA
HKD2_k127_1527639_2	398512.JQKC01000016_gene2837	1.854e-60	219.0	COG0515@1|root,COG0515@2|Bacteria,1TPYP@1239|Firmicutes,24ABN@186801|Clostridia,3WIN0@541000|Ruminococcaceae	186801|Clostridia	KLT	Protein tyrosine kinase	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HKD2_k127_1527639_0	394503.Ccel_0312	0.0	1852.0	COG0085@1|root,COG0085@2|Bacteria,1TP96@1239|Firmicutes,247J1@186801|Clostridia,36EKQ@31979|Clostridiaceae	186801|Clostridia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	-	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
HKD2_k127_1527639_1	935948.KE386495_gene1519	2.711e-280	864.0	COG0086@1|root,COG0086@2|Bacteria,1TNYT@1239|Firmicutes,24925@186801|Clostridia,42FED@68295|Thermoanaerobacterales	186801|Clostridia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	-	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
HKD2_k127_1532700_0	697303.Thewi_2463	3.406e-107	360.0	COG0477@1|root,COG2814@2|Bacteria,1TRUT@1239|Firmicutes,25E84@186801|Clostridia,42FN6@68295|Thermoanaerobacterales	186801|Clostridia	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
HKD2_k127_1532700_1	1408422.JHYF01000012_gene3210	3.161e-26	109.0	COG0642@1|root,COG2205@2|Bacteria,1TQMV@1239|Firmicutes,247SE@186801|Clostridia,36ERF@31979|Clostridiaceae	186801|Clostridia	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	5TM-5TMR_LYT,HATPase_c,HisKA,PAS,PAS_3,PAS_8,PAS_9,PocR
HKD2_k127_1534152_2	293826.Amet_0531	1.409e-51	187.0	COG0406@1|root,COG0406@2|Bacteria,1V6ES@1239|Firmicutes,24BUG@186801|Clostridia,36IHG@31979|Clostridiaceae	186801|Clostridia	G	Belongs to the phosphoglycerate mutase family	-	-	-	-	-	-	-	-	-	-	-	-	His_Phos_1
HKD2_k127_1534152_1	1345695.CLSA_c11970	2.138e-64	230.0	COG0500@1|root,COG2226@2|Bacteria,1V1WE@1239|Firmicutes,24CT5@186801|Clostridia,36JD0@31979|Clostridiaceae	186801|Clostridia	Q	PFAM Methyltransferase	rlmA	-	2.1.1.187	ko:K00563	-	-	R07233	RC00003	ko00000,ko01000,ko03009	-	-	-	Methyltransf_11,Methyltransf_25,Methyltransf_31
HKD2_k127_1534152_0	574375.BAGA_11900	3.498e-83	283.0	COG1670@1|root,COG1670@2|Bacteria,1VVI3@1239|Firmicutes	1239|Firmicutes	J	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HKD2_k127_1534152_5	305900.GV64_22940	8.729e-05	50.0	COG0346@1|root,COG0346@2|Bacteria,1RGZ8@1224|Proteobacteria,1S66M@1236|Gammaproteobacteria,1XKG4@135619|Oceanospirillales	135619|Oceanospirillales	E	PFAM Glyoxalase bleomycin resistance protein dioxygenase	-	-	-	ko:K08234	-	-	-	-	ko00000	-	-	-	Glyoxalase
HKD2_k127_1534152_4	1230342.CTM_06911	4.457e-21	93.0	2C95S@1|root,33HPC@2|Bacteria,1VJZ1@1239|Firmicutes,24UBF@186801|Clostridia,36PHY@31979|Clostridiaceae	186801|Clostridia	S	Domain of unknown function (DUF4177)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4177
HKD2_k127_1534215_2	290402.Cbei_3583	1.344e-88	302.0	COG0596@1|root,COG0596@2|Bacteria,1V202@1239|Firmicutes,24FDT@186801|Clostridia,36VN0@31979|Clostridiaceae	186801|Clostridia	S	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
HKD2_k127_1534215_1	1499683.CCFF01000017_gene2042	4.943e-96	316.0	COG3981@1|root,COG3981@2|Bacteria,1VA6C@1239|Firmicutes,24HZ2@186801|Clostridia,36INJ@31979|Clostridiaceae	186801|Clostridia	S	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
HKD2_k127_1534215_0	1321778.HMPREF1982_02887	6.504e-123	398.0	COG0030@1|root,COG0030@2|Bacteria,1TPC0@1239|Firmicutes,24ADN@186801|Clostridia	186801|Clostridia	J	Ribosomal RNA adenine dimethylase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Peptidase_S51,RrnaAD
HKD2_k127_1534215_3	931276.Cspa_c37540	2.54e-79	266.0	COG1051@1|root,COG1051@2|Bacteria,1V6D5@1239|Firmicutes,24HNE@186801|Clostridia,36JDR@31979|Clostridiaceae	186801|Clostridia	F	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
HKD2_k127_1534215_5	536227.CcarbDRAFT_0685	3.263e-24	104.0	COG4942@1|root,COG4942@2|Bacteria,1VQJA@1239|Firmicutes,25ECN@186801|Clostridia,36NHY@31979|Clostridiaceae	186801|Clostridia	D	peptidase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1534215_4	1487921.DP68_01370	2.485e-74	251.0	COG1765@1|root,COG1765@2|Bacteria,1V7SN@1239|Firmicutes,24SS3@186801|Clostridia,36K9Q@31979|Clostridiaceae	186801|Clostridia	O	OsmC-like protein	-	-	-	ko:K07397	-	-	-	-	ko00000	-	-	-	OsmC
HKD2_k127_1534215_6	768710.DesyoDRAFT_4134	6.727e-06	48.0	COG2334@1|root,COG2334@2|Bacteria,1TSKH@1239|Firmicutes,24ZRZ@186801|Clostridia	186801|Clostridia	S	homoserine kinase type II	-	-	-	-	-	-	-	-	-	-	-	-	APH
HKD2_k127_1552980_7	696281.Desru_0028	5.825e-11	62.0	COG5002@1|root,COG5002@2|Bacteria,1TPB6@1239|Firmicutes,24AV5@186801|Clostridia,263PJ@186807|Peptococcaceae	186801|Clostridia	T	GHKL domain	vanS	-	2.7.13.3	ko:K18350	ko01502,ko02020,map01502,map02020	M00652,M00657	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko01504,ko02022	-	-	-	HAMP,HATPase_c,HisKA
HKD2_k127_1552980_2	767817.Desgi_1738	7.958e-170	537.0	COG1686@1|root,COG1686@2|Bacteria,1TQ8M@1239|Firmicutes,24AQE@186801|Clostridia,264BZ@186807|Peptococcaceae	186801|Clostridia	M	Belongs to the peptidase S11 family	-	-	3.4.16.4	ko:K07258	ko00550,ko01100,map00550,map01100	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	Peptidase_S11
HKD2_k127_1552980_3	1131730.BAVI_24943	6.465e-92	305.0	COG4767@1|root,COG4767@2|Bacteria,1VKIA@1239|Firmicutes,4HQZW@91061|Bacilli,1ZJND@1386|Bacillus	91061|Bacilli	V	VanZ like family	-	-	-	-	-	-	-	-	-	-	-	-	VanZ
HKD2_k127_1552980_5	1033810.HLPCO_001056	3.672e-36	139.0	COG0640@1|root,COG0640@2|Bacteria,2NQ74@2323|unclassified Bacteria	2|Bacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	HTH_20,HTH_5
HKD2_k127_1552980_4	1449126.JQKL01000033_gene1185	1.008e-56	201.0	COG5561@1|root,COG5561@2|Bacteria,1V8K2@1239|Firmicutes,24HKJ@186801|Clostridia,26BFX@186813|unclassified Clostridiales	186801|Clostridia	S	CGGC	-	-	-	-	-	-	-	-	-	-	-	-	CGGC
HKD2_k127_1552980_1	1123288.SOV_3c08200	2.772e-227	706.0	COG2108@1|root,COG2108@2|Bacteria,1V016@1239|Firmicutes,4H2X3@909932|Negativicutes	909932|Negativicutes	S	Radical SAM	-	-	-	ko:K07129	-	-	-	-	ko00000	-	-	-	Radical_SAM
HKD2_k127_1552980_6	767817.Desgi_3463	3.061e-26	108.0	COG0500@1|root,COG2226@2|Bacteria,1UW06@1239|Firmicutes,25EJR@186801|Clostridia,263YW@186807|Peptococcaceae	186801|Clostridia	H	Methylase involved in ubiquinone menaquinone biosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_12,Methyltransf_23,Methyltransf_31
HKD2_k127_1552980_0	696281.Desru_2195	1.325e-249	781.0	COG0574@1|root,COG3848@1|root,COG0574@2|Bacteria,COG3848@2|Bacteria,1UIEA@1239|Firmicutes,25EJM@186801|Clostridia,2610V@186807|Peptococcaceae	186801|Clostridia	GT	pyruvate phosphate dikinase, PEP	ppdK	-	2.7.9.1,2.7.9.2	ko:K01006,ko:K01007	ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173,M00374	R00199,R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
HKD2_k127_155474_2	756499.Desde_2792	8.659e-97	324.0	COG0616@1|root,COG0616@2|Bacteria,1U2Z9@1239|Firmicutes,24DAF@186801|Clostridia,26169@186807|Peptococcaceae	186801|Clostridia	OU	ClpP class periplasmic serine protease	-	-	-	-	-	-	-	-	-	-	-	-	SDH_sah
HKD2_k127_155474_1	1128398.Curi_c12920	2.19e-104	344.0	COG0682@1|root,COG0682@2|Bacteria,1TPAK@1239|Firmicutes,24APG@186801|Clostridia,267UB@186813|unclassified Clostridiales	186801|Clostridia	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	lgt	-	-	ko:K13292	-	-	-	-	ko00000,ko01000	-	-	-	LGT
HKD2_k127_155474_3	1121289.JHVL01000030_gene400	7.623e-65	226.0	COG2001@1|root,COG2001@2|Bacteria,1V3JD@1239|Firmicutes,24HB9@186801|Clostridia,36I1C@31979|Clostridiaceae	186801|Clostridia	K	Belongs to the MraZ family	mraZ	-	-	ko:K03925	-	-	-	-	ko00000	-	-	-	MraZ
HKD2_k127_155474_0	1286171.EAL2_c10400	2.296e-116	382.0	COG0275@1|root,COG0682@1|root,COG0275@2|Bacteria,COG0682@2|Bacteria,1TNZV@1239|Firmicutes,248B5@186801|Clostridia,25UQQ@186806|Eubacteriaceae	186801|Clostridia	J	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA	rsmH	-	2.1.1.199	ko:K03438	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltransf_5
HKD2_k127_155679_3	1304284.L21TH_0931	8.515e-15	75.0	COG1453@1|root,COG1453@2|Bacteria,1TQ5N@1239|Firmicutes,247SD@186801|Clostridia,36F1U@31979|Clostridiaceae	186801|Clostridia	C	aldo keto reductase	-	-	-	ko:K07079	-	-	-	-	ko00000	-	-	-	Aldo_ket_red,Fer4_17
HKD2_k127_155679_0	1321778.HMPREF1982_00926	7.965e-141	465.0	28IUJ@1|root,2Z8T8@2|Bacteria,1W5W7@1239|Firmicutes,25E72@186801|Clostridia	186801|Clostridia	S	Putative ATP-binding cassette	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran_2
HKD2_k127_155679_1	999413.HMPREF1094_04212	1.889e-102	338.0	COG1131@1|root,COG1131@2|Bacteria,1TQIH@1239|Firmicutes,3VPWK@526524|Erysipelotrichia	526524|Erysipelotrichia	V	Psort location CytoplasmicMembrane, score	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD2_k127_155679_2	1499689.CCNN01000014_gene3172	3.518e-21	93.0	COG0281@1|root,COG0281@2|Bacteria,1TPJ3@1239|Firmicutes,2487U@186801|Clostridia,36DTC@31979|Clostridiaceae	186801|Clostridia	C	malic enzyme	-	-	1.1.1.38	ko:K00027	ko00620,ko01200,ko02020,map00620,map01200,map02020	-	R00214	RC00105	ko00000,ko00001,ko01000	-	-	-	Malic_M,malic
HKD2_k127_1584237_4	240015.ACP_1358	5.988e-06	58.0	COG4447@1|root,COG4447@2|Bacteria,3Y2SN@57723|Acidobacteria,2JIF7@204432|Acidobacteriia	204432|Acidobacteriia	S	Sortilin, neurotensin receptor 3,	-	-	-	-	-	-	-	-	-	-	-	-	Sortilin-Vps10
HKD2_k127_1584237_1	768706.Desor_2383	2.636e-63	218.0	COG3304@1|root,COG3304@2|Bacteria,1VADH@1239|Firmicutes,24NFV@186801|Clostridia,2657F@186807|Peptococcaceae	186801|Clostridia	S	membrane	yccF	-	-	-	-	-	-	-	-	-	-	-	YccF
HKD2_k127_1584237_3	1304284.L21TH_0602	2.404e-10	72.0	28SRE@1|root,2ZF1B@2|Bacteria,1W33E@1239|Firmicutes,24W3Z@186801|Clostridia,36PKN@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	CbiX,Ferrochelatase
HKD2_k127_1584237_2	941824.TCEL_01057	3.525e-40	153.0	COG3610@1|root,COG3610@2|Bacteria,1V6P0@1239|Firmicutes,24R80@186801|Clostridia,36JMC@31979|Clostridiaceae	186801|Clostridia	S	Threonine/Serine exporter, ThrE	-	-	-	-	-	-	-	-	-	-	-	-	ThrE_2
HKD2_k127_1584237_0	1031288.AXAA01000017_gene189	3.147e-69	243.0	COG2966@1|root,COG2966@2|Bacteria,1TSE8@1239|Firmicutes,24A25@186801|Clostridia,36EA1@31979|Clostridiaceae	186801|Clostridia	S	hmm pf06738	-	-	-	-	-	-	-	-	-	-	-	-	ThrE
HKD2_k127_1585049_0	1031288.AXAA01000014_gene366	1.313e-245	775.0	COG0272@1|root,COG0272@2|Bacteria,1TPQ3@1239|Firmicutes,248AX@186801|Clostridia,36EUE@31979|Clostridiaceae	186801|Clostridia	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	-	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5
HKD2_k127_1585049_1	720554.Clocl_3940	1.125e-234	741.0	COG0210@1|root,COG0210@2|Bacteria,1TPSU@1239|Firmicutes,247RM@186801|Clostridia,3WGKX@541000|Ruminococcaceae	186801|Clostridia	L	ATP-dependent DNA helicase	pcrA	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
HKD2_k127_1585049_5	2325.TKV_c00470	1.085e-56	212.0	COG2203@1|root,COG2206@1|root,COG3850@1|root,COG2203@2|Bacteria,COG2206@2|Bacteria,COG3850@2|Bacteria,1UZN2@1239|Firmicutes,248SE@186801|Clostridia,42GDE@68295|Thermoanaerobacterales	186801|Clostridia	T	PFAM Metal-dependent phosphohydrolase, HD	-	-	-	-	-	-	-	-	-	-	-	-	DUF3369,GAF,GAF_2,HAMP,HD,HD_5,PAS_9,PocR,Response_reg
HKD2_k127_1585049_4	1408422.JHYF01000009_gene2097	2.455e-102	338.0	COG1145@1|root,COG1145@2|Bacteria,1TPAZ@1239|Firmicutes,249NJ@186801|Clostridia,36F9G@31979|Clostridiaceae	186801|Clostridia	C	binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_6
HKD2_k127_1585049_3	555079.Toce_1497	1.52e-155	501.0	COG0151@1|root,COG0151@2|Bacteria,1UHN9@1239|Firmicutes,25E76@186801|Clostridia,42FB3@68295|Thermoanaerobacterales	186801|Clostridia	F	Belongs to the GARS family	purD	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	GARS_A,GARS_C,GARS_N
HKD2_k127_1585049_2	935948.KE386494_gene641	1.238e-182	580.0	COG0138@1|root,COG0138@2|Bacteria,1TPQ5@1239|Firmicutes,24AB8@186801|Clostridia,42EZN@68295|Thermoanaerobacterales	186801|Clostridia	F	Bifunctional purine biosynthesis protein PurH	purH	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iHN637.CLJU_RS04230	AICARFT_IMPCHas,MGS
HKD2_k127_1586500_16	357809.Cphy_2756	9.751e-21	93.0	COG1670@1|root,COG1670@2|Bacteria	2|Bacteria	J	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins	-	-	2.3.1.82	ko:K18816	-	-	-	-	br01600,ko00000,ko01000,ko01504	-	-	-	Acetyltransf_1,Acetyltransf_3
HKD2_k127_1586500_13	536227.CcarbDRAFT_1034	5.357e-41	158.0	COG3758@1|root,COG3758@2|Bacteria,1VH52@1239|Firmicutes,24P8J@186801|Clostridia,36ECZ@31979|Clostridiaceae	186801|Clostridia	S	HutD	-	-	-	-	-	-	-	-	-	-	-	-	HutD
HKD2_k127_1586500_17	580327.Tthe_2205	2.243e-11	66.0	COG0450@1|root,COG0450@2|Bacteria,1TQU7@1239|Firmicutes,24A31@186801|Clostridia,42F7R@68295|Thermoanaerobacterales	186801|Clostridia	O	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides	-	-	1.11.1.15	ko:K03386	ko04214,map04214	-	-	-	ko00000,ko00001,ko01000,ko04147	-	-	-	1-cysPrx_C,AhpC-TSA
HKD2_k127_1586500_14	580327.Tthe_2205	1.375e-40	153.0	COG0450@1|root,COG0450@2|Bacteria,1TQU7@1239|Firmicutes,24A31@186801|Clostridia,42F7R@68295|Thermoanaerobacterales	186801|Clostridia	O	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides	-	-	1.11.1.15	ko:K03386	ko04214,map04214	-	-	-	ko00000,ko00001,ko01000,ko04147	-	-	-	1-cysPrx_C,AhpC-TSA
HKD2_k127_1586500_6	1499689.CCNN01000014_gene3273	4.156e-129	417.0	COG0428@1|root,COG0428@2|Bacteria,1TP7J@1239|Firmicutes,247Q2@186801|Clostridia,36FEF@31979|Clostridiaceae	186801|Clostridia	P	Zinc transporter	-	-	-	ko:K07238	-	-	-	-	ko00000,ko02000	2.A.5.5	-	-	Zip
HKD2_k127_1586500_7	509191.AEDB02000021_gene3102	8.632e-109	358.0	COG0489@1|root,COG0489@2|Bacteria,1TQ34@1239|Firmicutes,24817@186801|Clostridia,3WGBQ@541000|Ruminococcaceae	186801|Clostridia	D	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP	-	-	-	-	-	-	-	-	-	-	-	-	Nitro_FeMo-Co,ParA
HKD2_k127_1586500_15	1121289.JHVL01000014_gene1814	5.104e-24	103.0	COG1905@1|root,COG1905@2|Bacteria,1VFEK@1239|Firmicutes,24QMM@186801|Clostridia,36NC3@31979|Clostridiaceae	186801|Clostridia	C	Thioredoxin-like [2Fe-2S] ferredoxin	fhmD	-	-	-	-	-	-	-	-	-	-	-	2Fe-2S_thioredx
HKD2_k127_1586500_1	1304284.L21TH_0542	1.307e-230	726.0	COG1145@1|root,COG4624@1|root,COG1145@2|Bacteria,COG4624@2|Bacteria,1TRB4@1239|Firmicutes,24BF5@186801|Clostridia,36E2Y@31979|Clostridiaceae	186801|Clostridia	C	PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	FeS,Fe_hyd_lg_C,Fer4,Fer4_7,PAS
HKD2_k127_1586500_5	1304284.L21TH_0543	5.974e-166	530.0	COG2208@1|root,COG2208@2|Bacteria,1TQUC@1239|Firmicutes,248FZ@186801|Clostridia,36FUJ@31979|Clostridiaceae	186801|Clostridia	KT	stage II sporulation	-	-	-	-	-	-	-	-	-	-	-	-	SpoIIE
HKD2_k127_1586500_0	1304284.L21TH_0544	3.161e-232	726.0	COG1142@1|root,COG4624@1|root,COG1142@2|Bacteria,COG4624@2|Bacteria,1TQIR@1239|Firmicutes,248BS@186801|Clostridia,36E6A@31979|Clostridiaceae	186801|Clostridia	C	-hydrogenase	-	-	1.12.7.2	ko:K00533	-	-	R00019	-	ko00000,ko01000	-	-	-	Fe_hyd_lg_C,Fer4
HKD2_k127_1586500_12	1499689.CCNN01000009_gene2816	1.62e-71	246.0	COG0406@1|root,COG0406@2|Bacteria,1V6ES@1239|Firmicutes,24BUG@186801|Clostridia,36IHG@31979|Clostridiaceae	186801|Clostridia	G	Belongs to the phosphoglycerate mutase family	-	-	-	-	-	-	-	-	-	-	-	-	His_Phos_1
HKD2_k127_1586500_10	1499967.BAYZ01000074_gene2156	4.346e-80	275.0	COG2816@1|root,COG2816@2|Bacteria	2|Bacteria	L	NAD+ diphosphatase activity	nudC	-	1.3.7.1,3.6.1.22	ko:K03426,ko:K20449	ko00760,ko01100,ko01120,ko04146,map00760,map01100,map01120,map04146	-	R00103,R03004,R03164,R11104	RC00002,RC02422	ko00000,ko00001,ko01000	-	-	-	NUDIX,NUDIX-like,zf-NADH-PPase
HKD2_k127_1586500_3	941824.TCEL_00477	6.407e-198	628.0	COG1115@1|root,COG1115@2|Bacteria,1TNZP@1239|Firmicutes,247S6@186801|Clostridia,36F13@31979|Clostridiaceae	186801|Clostridia	E	amino acid carrier protein	yrbD	-	-	ko:K03310	-	-	-	-	ko00000	2.A.25	-	-	Na_Ala_symp
HKD2_k127_1586500_11	1304284.L21TH_1729	5.062e-79	272.0	COG0840@1|root,COG0840@2|Bacteria,1TSAG@1239|Firmicutes,24FJ7@186801|Clostridia,36JPP@31979|Clostridiaceae	186801|Clostridia	NT	PFAM chemotaxis sensory transducer	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	Diacid_rec,GFO_IDH_MocA,MCPsignal
HKD2_k127_1586500_18	1410653.JHVC01000001_gene1641	3.772e-07	53.0	2BBAI@1|root,324T9@2|Bacteria,1UF70@1239|Firmicutes,24VYN@186801|Clostridia,36P2W@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1586500_4	1443125.Z962_12550	2.229e-168	535.0	COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,1TP4F@1239|Firmicutes,248MM@186801|Clostridia,36DJS@31979|Clostridiaceae	186801|Clostridia	H	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate	ribD	-	1.1.1.193,3.5.4.26	ko:K11752	ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024	M00125	R03458,R03459	RC00204,RC00933	ko00000,ko00001,ko00002,ko01000	-	-	-	RibD_C,dCMP_cyt_deam_1
HKD2_k127_1586500_8	293826.Amet_1019	3.922e-97	321.0	COG0307@1|root,COG0307@2|Bacteria,1V1EP@1239|Firmicutes,24FVK@186801|Clostridia,36GCB@31979|Clostridiaceae	186801|Clostridia	H	riboflavin synthase, alpha subunit	ribE	-	2.5.1.9	ko:K00793	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00066	RC00958,RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	Lum_binding
HKD2_k127_1586500_2	1033810.HLPCO_001293	1.781e-208	653.0	COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,2NNKV@2323|unclassified Bacteria	2|Bacteria	H	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate	ribBA	GO:0003674,GO:0003824,GO:0003933,GO:0003935,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0008686,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0016829,GO:0016830,GO:0017144,GO:0018130,GO:0019238,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	3.5.4.25,4.1.99.12	ko:K01497,ko:K02858,ko:K14652	ko00740,ko00790,ko01100,ko01110,ko02024,map00740,map00790,map01100,map01110,map02024	M00125,M00840	R00425,R07281	RC00293,RC01792,RC01815,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS10830,iSB619.SA_RS08945	DHBP_synthase,GTP_cyclohydro2
HKD2_k127_1586500_9	994573.T472_0205275	2.488e-80	269.0	COG0054@1|root,COG0054@2|Bacteria,1V1DA@1239|Firmicutes,24FRS@186801|Clostridia,36HYD@31979|Clostridiaceae	186801|Clostridia	H	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin	ribH	-	2.5.1.78	ko:K00794	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R04457	RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	DMRL_synthase
HKD2_k127_1607191_1	1487921.DP68_15490	1.31e-194	612.0	COG1292@1|root,COG1292@2|Bacteria,1TRS6@1239|Firmicutes,2482K@186801|Clostridia,36E19@31979|Clostridiaceae	186801|Clostridia	M	Belongs to the BCCT transporter (TC 2.A.15) family	-	-	-	ko:K02168,ko:K05020	-	-	-	-	ko00000,ko02000	2.A.15.1.1,2.A.15.1.11,2.A.15.1.3,2.A.15.1.4	-	-	BCCT
HKD2_k127_1607191_0	1487921.DP68_15495	1.176e-219	693.0	COG3829@1|root,COG3829@2|Bacteria,1TP0E@1239|Firmicutes,247MB@186801|Clostridia,36EY7@31979|Clostridiaceae	186801|Clostridia	KT	Bacterial regulatory protein, Fis family	-	-	-	ko:K06714	-	-	-	-	ko00000,ko03000	-	-	-	HTH_8,PAS,PAS_4,PAS_8,PAS_9,Sigma54_activat
HKD2_k127_1607191_2	573061.Clocel_0588	3.506e-22	101.0	COG2733@1|root,COG2733@2|Bacteria,1TS8F@1239|Firmicutes,24GP2@186801|Clostridia,36JDE@31979|Clostridiaceae	186801|Clostridia	S	Protein of unknown function (DUF445)	-	-	-	-	-	-	-	-	-	-	-	-	DUF445
HKD2_k127_161178_2	1195236.CTER_0118	1.618e-100	331.0	COG0481@1|root,COG0481@2|Bacteria,1TP0G@1239|Firmicutes,247V8@186801|Clostridia,3WGRU@541000|Ruminococcaceae	186801|Clostridia	M	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner	lepA	-	-	ko:K03596	ko05134,map05134	-	-	-	ko00000,ko00001	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2,LepA_C
HKD2_k127_161178_10	293826.Amet_3054	4.731e-36	152.0	COG0860@1|root,COG0860@2|Bacteria,1TSFS@1239|Firmicutes,2488U@186801|Clostridia,36F21@31979|Clostridiaceae	186801|Clostridia	M	stage II sporulation protein P	spoIIP	-	-	ko:K06385	-	-	-	-	ko00000	-	-	-	SpoIIP
HKD2_k127_161178_0	203119.Cthe_1038	8.646e-133	430.0	COG0680@1|root,COG0680@2|Bacteria,1TPFY@1239|Firmicutes,248TE@186801|Clostridia,3WGVA@541000|Ruminococcaceae	186801|Clostridia	C	Initiates the rapid degradation of small, acid-soluble proteins during spore germination	gpr	-	3.4.24.78	ko:K06012	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_A25
HKD2_k127_161178_14	1321778.HMPREF1982_04007	1.465e-18	89.0	COG0268@1|root,COG0268@2|Bacteria,1VEGX@1239|Firmicutes,24QNX@186801|Clostridia,269UH@186813|unclassified Clostridiales	186801|Clostridia	J	Binds directly to 16S ribosomal RNA	rpsT	-	-	ko:K02968	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S20p
HKD2_k127_161178_7	293826.Amet_3057	4.488e-61	224.0	COG1466@1|root,COG1466@2|Bacteria,1TRM0@1239|Firmicutes,24ASN@186801|Clostridia,36FMH@31979|Clostridiaceae	186801|Clostridia	L	DNA polymerase III delta subunit	holA	-	2.7.7.7	ko:K02340	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta
HKD2_k127_161178_4	1408422.JHYF01000009_gene1963	1.126e-90	314.0	COG0534@1|root,COG0534@2|Bacteria,1UZDQ@1239|Firmicutes,24F5D@186801|Clostridia,36VMW@31979|Clostridiaceae	186801|Clostridia	V	Polysaccharide biosynthesis C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	MatE
HKD2_k127_161178_1	340099.Teth39_1406	2.203e-109	383.0	COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,1TS9U@1239|Firmicutes,249VR@186801|Clostridia,42F11@68295|Thermoanaerobacterales	186801|Clostridia	S	TIGRFAM DNA internalization-related competence protein ComEC Rec2	comEC	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Competence,DUF4131,Lactamase_B
HKD2_k127_161178_5	1304284.L21TH_1237	2.021e-70	246.0	COG1234@1|root,COG1234@2|Bacteria,1V1TF@1239|Firmicutes,25CI5@186801|Clostridia,36WWI@31979|Clostridiaceae	186801|Clostridia	S	Metallo-beta-lactamase superfamily	ElaC	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
HKD2_k127_161178_11	1120746.CCNL01000014_gene2160	1.792e-32	130.0	COG1950@1|root,COG1950@2|Bacteria	2|Bacteria	S	Mycobacterial 4 TMS phage holin, superfamily IV	-	-	-	-	-	-	-	-	-	-	-	-	Phage_holin_4_2
HKD2_k127_161178_16	697281.Mahau_0600	1.04e-12	70.0	2E9A5@1|root,333I5@2|Bacteria,1VEE1@1239|Firmicutes,24T9Q@186801|Clostridia,42HBX@68295|Thermoanaerobacterales	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_161178_3	580327.Tthe_1161	1.714e-99	338.0	COG0013@1|root,COG0013@2|Bacteria,1TSBZ@1239|Firmicutes,249VN@186801|Clostridia,42EJX@68295|Thermoanaerobacterales	186801|Clostridia	J	PFAM Threonyl alanyl tRNA synthetase, SAD	alaXL	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
HKD2_k127_161178_15	1230342.CTM_18271	1.015e-15	81.0	2FJ2Q@1|root,34AT1@2|Bacteria,1VZE8@1239|Firmicutes,24RDN@186801|Clostridia,36KJ9@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_161178_6	857293.CAAU_0989	3.828e-63	227.0	COG0679@1|root,COG0679@2|Bacteria,1UY4N@1239|Firmicutes,24ACC@186801|Clostridia,36DT1@31979|Clostridiaceae	186801|Clostridia	S	auxin efflux carrier	-	-	-	ko:K07088	-	-	-	-	ko00000	-	-	-	Mem_trans,SBF
HKD2_k127_161178_17	1469948.JPNB01000003_gene226	1.309e-10	65.0	2BX75@1|root,32YCI@2|Bacteria,1VEDY@1239|Firmicutes,24QPW@186801|Clostridia,36MPW@31979|Clostridiaceae	186801|Clostridia	S	Small acid-soluble spore	sasP	-	-	ko:K06421	-	-	-	-	ko00000	-	-	-	SASP
HKD2_k127_161178_9	1511.CLOST_0703	1.034e-51	186.0	COG1607@1|root,COG1607@2|Bacteria,1VD4Z@1239|Firmicutes,24PKR@186801|Clostridia	186801|Clostridia	I	Thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
HKD2_k127_161178_12	886882.PPSC2_c3789	1.849e-32	132.0	2DJH9@1|root,3064B@2|Bacteria,1TZ5Y@1239|Firmicutes,4I8DD@91061|Bacilli,26ZNE@186822|Paenibacillaceae	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_161178_13	37659.JNLN01000001_gene861	1.15e-24	105.0	COG1278@1|root,COG1278@2|Bacteria,1VBBH@1239|Firmicutes,24QK9@186801|Clostridia,36MNT@31979|Clostridiaceae	186801|Clostridia	K	Probable zinc-ribbon domain	-	-	-	-	-	-	-	-	-	-	-	-	zf-trcl
HKD2_k127_161178_8	929506.CbC4_1385	4.025e-56	201.0	COG0079@1|root,COG0079@2|Bacteria,1TP5D@1239|Firmicutes,248Q0@186801|Clostridia,36DWQ@31979|Clostridiaceae	186801|Clostridia	E	PFAM aminotransferase class I and II	cobD2	-	4.1.1.81	ko:K04720	ko00860,map00860	-	R06530	RC00517	ko00000,ko00001,ko01000	-	-	iHN637.CLJU_RS15770	Aminotran_1_2
HKD2_k127_1615070_10	596330.HMPREF0628_1345	1.424e-12	67.0	COG0103@1|root,COG0103@2|Bacteria,1V3MQ@1239|Firmicutes,24H94@186801|Clostridia,22HJC@1570339|Peptoniphilaceae	186801|Clostridia	J	Belongs to the universal ribosomal protein uS9 family	rpsI	-	-	ko:K02996	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S9
HKD2_k127_1615070_8	340099.Teth39_0442	3.242e-36	140.0	COG1694@1|root,COG1694@2|Bacteria,1VA3F@1239|Firmicutes,24NNE@186801|Clostridia,42GKX@68295|Thermoanaerobacterales	186801|Clostridia	S	PFAM MazG nucleotide pyrophosphohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	MazG
HKD2_k127_1615070_3	1408422.JHYF01000006_gene1129	1.272e-91	304.0	COG0512@1|root,COG0512@2|Bacteria,1TT9R@1239|Firmicutes,24FR0@186801|Clostridia,36I54@31979|Clostridiaceae	186801|Clostridia	EH	Glutamine amidotransferase of anthranilate synthase	pabA	-	2.6.1.85,4.1.3.27	ko:K01658,ko:K01664	ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986,R01716	RC00010,RC01418,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS17720	GATase
HKD2_k127_1615070_0	1391646.AVSU01000053_gene944	8.926e-158	510.0	COG0147@1|root,COG0147@2|Bacteria,1TQAP@1239|Firmicutes,24946@186801|Clostridia,25QW7@186804|Peptostreptococcaceae	186801|Clostridia	EH	Anthranilate synthase component I, N terminal region	pabB	-	2.6.1.85,4.1.3.27,4.1.3.38	ko:K01657,ko:K01665,ko:K03342,ko:K13950	ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986,R01716,R05553	RC00010,RC01418,RC01843,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Anth_synt_I_N,Chorismate_bind
HKD2_k127_1615070_5	293826.Amet_2159	4.459e-55	203.0	COG0115@1|root,COG0115@2|Bacteria,1TPY2@1239|Firmicutes,25CC4@186801|Clostridia,36WT9@31979|Clostridiaceae	186801|Clostridia	EH	Amino-transferase class IV	ilvE2	-	2.6.1.42,4.1.3.38	ko:K00826,ko:K02619	ko00270,ko00280,ko00290,ko00770,ko00790,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map00790,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R05553,R10991	RC00006,RC00036,RC01843,RC02148	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
HKD2_k127_1615070_2	1286171.EAL2_c17140	8.941e-95	313.0	COG0302@1|root,COG0302@2|Bacteria,1TRNM@1239|Firmicutes,24867@186801|Clostridia,25W67@186806|Eubacteriaceae	186801|Clostridia	H	GTP cyclohydrolase I	folE	-	3.5.4.16	ko:K01495	ko00790,ko01100,map00790,map01100	M00126,M00841,M00842,M00843	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	-	GTP_cyclohydroI
HKD2_k127_1615070_1	293826.Amet_2161	1.702e-119	389.0	COG0294@1|root,COG0294@2|Bacteria,1TPKT@1239|Firmicutes,248BE@186801|Clostridia,36EFV@31979|Clostridiaceae	186801|Clostridia	H	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives	folP	-	2.5.1.15	ko:K00796	ko00790,ko01100,map00790,map01100	M00126,M00841	R03066,R03067	RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS03115	Pterin_bind
HKD2_k127_1615070_9	665952.HMPREF1015_02770	9.893e-25	107.0	COG1539@1|root,COG1539@2|Bacteria,1VA0I@1239|Firmicutes,4HKKK@91061|Bacilli,1ZGZ7@1386|Bacillus	91061|Bacilli	H	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin	folB	-	1.13.11.81,4.1.2.25,5.1.99.8	ko:K01633	ko00790,ko01100,map00790,map01100	M00126,M00840	R03504,R11037,R11073	RC00721,RC00943,RC01479,RC03333,RC03334	ko00000,ko00001,ko00002,ko01000	-	-	-	FolB
HKD2_k127_1615070_6	1128398.Curi_c21040	6.098e-55	196.0	COG0801@1|root,COG0801@2|Bacteria,1V6PR@1239|Firmicutes,249YP@186801|Clostridia,26BYU@186813|unclassified Clostridiales	186801|Clostridia	H	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK)	folK	-	2.7.6.3,4.1.2.25	ko:K00950,ko:K13940	ko00790,ko01100,map00790,map01100	M00126,M00841	R03503,R03504	RC00002,RC00017,RC00721,RC00943	ko00000,ko00001,ko00002,ko01000	-	-	-	FolB,HPPK
HKD2_k127_1615070_7	293826.Amet_4325	2.295e-42	162.0	COG0655@1|root,COG0655@2|Bacteria,1V26K@1239|Firmicutes,24IAS@186801|Clostridia,36J7E@31979|Clostridiaceae	186801|Clostridia	S	NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
HKD2_k127_1615070_4	857293.CAAU_1187	3.371e-64	228.0	COG0860@1|root,COG0860@2|Bacteria,1TQ74@1239|Firmicutes,24FT2@186801|Clostridia,36I6H@31979|Clostridiaceae	186801|Clostridia	M	N-acetylmuramoyl-L-alanine amidase	cwlD	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	Amidase_3
HKD2_k127_1615070_11	1128398.Curi_c11090	2.09e-11	65.0	COG0426@1|root,COG0426@2|Bacteria,1VRFW@1239|Firmicutes,24BWR@186801|Clostridia	186801|Clostridia	C	beta-lactamase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1636320_8	445972.ANACOL_01476	7.067e-77	260.0	COG0559@1|root,COG0559@2|Bacteria,1TR24@1239|Firmicutes,2480A@186801|Clostridia,3WNCX@541000|Ruminococcaceae	186801|Clostridia	E	Branched-chain amino acid transport system / permease component	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HKD2_k127_1636320_3	445972.ANACOL_01477	2.518e-143	462.0	COG4177@1|root,COG4177@2|Bacteria,1TPMZ@1239|Firmicutes,248WH@186801|Clostridia,3WIQI@541000|Ruminococcaceae	186801|Clostridia	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997,ko:K01998,ko:K11961	ko02010,ko02024,map02010,map02024	M00237,M00323	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4,3.A.1.4.4,3.A.1.4.5	-	-	BPD_transp_2
HKD2_k127_1636320_4	445972.ANACOL_01478	3.784e-123	398.0	COG0411@1|root,COG0411@2|Bacteria,1TR0P@1239|Firmicutes,2490B@186801|Clostridia,3WH2I@541000|Ruminococcaceae	186801|Clostridia	E	ABC-type branched-chain amino acid transport systems ATPase component	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
HKD2_k127_1636320_5	1298920.KI911353_gene436	5.338e-109	356.0	COG0410@1|root,COG0410@2|Bacteria,1TPW4@1239|Firmicutes,247PN@186801|Clostridia,21YP8@1506553|Lachnoclostridium	186801|Clostridia	E	ATPases associated with a variety of cellular activities	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
HKD2_k127_1636320_1	357809.Cphy_1262	5.67e-167	529.0	COG2376@1|root,COG2376@2|Bacteria,1TP92@1239|Firmicutes,2488D@186801|Clostridia,21YFJ@1506553|Lachnoclostridium	186801|Clostridia	G	Psort location Cytoplasmic, score 8.87	dhaK	-	2.7.1.121	ko:K05878	ko00561,ko01100,map00561,map01100	-	R01012	RC00015,RC00017	ko00000,ko00001,ko01000	-	-	-	Dak1
HKD2_k127_1636320_6	445972.ANACOL_01481	3.362e-94	313.0	COG1461@1|root,COG1461@2|Bacteria,1V4FH@1239|Firmicutes,24FUX@186801|Clostridia	186801|Clostridia	S	Dihydroxyacetone kinase, L subunit	dhaL	-	2.7.1.121	ko:K05879	ko00561,ko01100,map00561,map01100	-	R01012	RC00015,RC00017	ko00000,ko00001,ko01000	-	-	-	Dak2
HKD2_k127_1636320_2	445972.ANACOL_01482	1.568e-144	477.0	COG2203@1|root,COG3829@1|root,COG2203@2|Bacteria,COG3829@2|Bacteria,1TP0E@1239|Firmicutes,24DTC@186801|Clostridia	186801|Clostridia	KT	Sigma-54 interaction domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HTH_23,HTH_7,HTH_8,Sigma54_activ_2,Sigma54_activat
HKD2_k127_1636320_7	357809.Cphy_1264	1.837e-83	278.0	299ND@1|root,2ZWQQ@2|Bacteria,1UZ92@1239|Firmicutes,24J56@186801|Clostridia,2212M@1506553|Lachnoclostridium	186801|Clostridia	S	L-2-amino-thiazoline-4-carboxylic acid hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	ATC_hydrolase
HKD2_k127_1636320_0	941824.TCEL_01996	3.706e-187	587.0	COG3039@1|root,COG3039@2|Bacteria,1TPFS@1239|Firmicutes,249JM@186801|Clostridia,36E38@31979|Clostridiaceae	186801|Clostridia	L	This gene contains a nucleotide ambiguity which may be the result of a sequencing error	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_6,DUF772
HKD2_k127_1637676_2	1304880.JAGB01000002_gene1871	5.662e-30	119.0	COG1883@1|root,COG1883@2|Bacteria,1TPEP@1239|Firmicutes,248ET@186801|Clostridia	186801|Clostridia	C	decarboxylase beta subunit	-	-	4.1.1.3	ko:K01572	ko00620,ko01100,map00620,map01100	-	R00217	RC00040	ko00000,ko00001,ko01000,ko02000	3.B.1.1.1	-	-	OAD_beta
HKD2_k127_1637676_0	1304880.JAGB01000002_gene1674	5.467e-75	261.0	COG1302@1|root,COG1302@2|Bacteria,1V1TU@1239|Firmicutes,24E60@186801|Clostridia	186801|Clostridia	F	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	Asp23,IPT
HKD2_k127_1637676_1	720554.Clocl_3983	1.578e-69	241.0	COG0122@1|root,COG0122@2|Bacteria,1TQAF@1239|Firmicutes,2495X@186801|Clostridia,3WGHY@541000|Ruminococcaceae	186801|Clostridia	L	8-oxoguanine DNA glycosylase	alkA	-	4.2.99.18	ko:K03660	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD,OGG_N
HKD2_k127_1641410_0	272562.CA_C2756	3.04e-224	709.0	COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247Q0@186801|Clostridia,36E82@31979|Clostridiaceae	186801|Clostridia	V	ABC transporter transmembrane region	-	-	-	ko:K18890	ko02010,map02010	M00707	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.106.13,3.A.1.106.5	-	-	ABC_membrane,ABC_tran
HKD2_k127_1641410_1	1196322.A370_04611	5.979e-200	638.0	COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247Q0@186801|Clostridia,36DEY@31979|Clostridiaceae	186801|Clostridia	V	ABC transporter transmembrane region	-	-	-	ko:K18889	ko02010,map02010	M00707	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.106.13,3.A.1.106.5	-	-	ABC_membrane,ABC_tran
HKD2_k127_1641410_2	498761.HM1_2167	1.257e-118	388.0	COG2070@1|root,COG2070@2|Bacteria,1TPX1@1239|Firmicutes,247YZ@186801|Clostridia	186801|Clostridia	K	2-nitropropane dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	NMO
HKD2_k127_1662710_7	545693.BMQ_3978	4.429e-91	308.0	COG0491@1|root,COG0491@2|Bacteria,1TSU6@1239|Firmicutes,4HC5H@91061|Bacilli,1ZQUN@1386|Bacillus	91061|Bacilli	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HKD2_k127_1662710_8	1410653.JHVC01000001_gene1354	6.836e-78	265.0	COG1279@1|root,COG1279@2|Bacteria,1V1Q2@1239|Firmicutes,24FSB@186801|Clostridia,36IZD@31979|Clostridiaceae	186801|Clostridia	S	PFAM Lysine exporter protein (LYSE YGGA)	-	-	-	ko:K06895	-	-	-	-	ko00000,ko02000	2.A.75.1	-	-	LysE
HKD2_k127_1662710_2	1410668.JNKC01000007_gene770	3.919e-136	452.0	COG1283@1|root,COG1283@2|Bacteria,1TP4K@1239|Firmicutes,247KT@186801|Clostridia,36DCM@31979|Clostridiaceae	186801|Clostridia	P	Na Pi-cotransporter II-like protein	-	-	-	ko:K03324	-	-	-	-	ko00000,ko02000	2.A.58.2	-	-	Na_Pi_cotrans,PhoU
HKD2_k127_1662710_9	1304284.L21TH_2733	1.432e-62	237.0	COG0840@1|root,COG0840@2|Bacteria,1TP5A@1239|Firmicutes,247S3@186801|Clostridia,36EVU@31979|Clostridiaceae	186801|Clostridia	NT	histidine kinase HAMP region domain protein	mcpC3	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	HAMP,MCPsignal,dCache_1,sCache_2
HKD2_k127_1662710_6	1033810.HLPCO_001733	8.058e-107	355.0	COG1575@1|root,COG1575@2|Bacteria,2NPNN@2323|unclassified Bacteria	2|Bacteria	H	UbiA prenyltransferase family	ubiA	-	2.5.1.74	ko:K02548	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R05617,R06858,R10757	RC02935,RC02936,RC03264	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
HKD2_k127_1662710_0	1540257.JQMW01000009_gene3050	5.756e-251	784.0	COG0513@1|root,COG0513@2|Bacteria,1TPAP@1239|Firmicutes,247IT@186801|Clostridia,36DXA@31979|Clostridiaceae	186801|Clostridia	L	Belongs to the DEAD box helicase family	cshA	-	3.6.4.13	ko:K05592	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019	-	-	-	DEAD,DbpA,Helicase_C
HKD2_k127_1662710_11	1121342.AUCO01000005_gene269	2.946e-33	131.0	COG3695@1|root,COG3695@2|Bacteria,1VC8H@1239|Firmicutes,24JGN@186801|Clostridia,36JM6@31979|Clostridiaceae	186801|Clostridia	L	6-O-methylguanine DNA methyltransferase, DNA binding domain	-	-	-	ko:K07443	-	-	-	-	ko00000	-	-	-	DNA_binding_1
HKD2_k127_1662710_1	1321778.HMPREF1982_01427	4.64e-174	566.0	COG0577@1|root,COG0577@2|Bacteria,1TR2D@1239|Firmicutes,2481J@186801|Clostridia,26B6K@186813|unclassified Clostridiales	186801|Clostridia	V	FtsX-like permease family	-	-	-	ko:K02004,ko:K11632	ko02010,ko02020,map02010,map02020	M00258,M00314,M00737,M00738	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.134.3	-	-	FtsX
HKD2_k127_1662710_3	1321778.HMPREF1982_01633	4.675e-121	393.0	COG1136@1|root,COG1136@2|Bacteria,1TNZG@1239|Firmicutes,247JX@186801|Clostridia,267ME@186813|unclassified Clostridiales	186801|Clostridia	V	Psort location CytoplasmicMembrane, score	-	-	-	ko:K02003,ko:K11635	ko02020,map02020	M00258,M00315	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.134.6	-	-	ABC_tran
HKD2_k127_1662710_5	1121289.JHVL01000012_gene1697	6.373e-108	359.0	COG0642@1|root,COG2205@2|Bacteria,1TSIC@1239|Firmicutes,248W8@186801|Clostridia,36FD9@31979|Clostridiaceae	186801|Clostridia	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
HKD2_k127_1662710_4	1230342.CTM_13723	3.626e-112	365.0	COG0745@1|root,COG0745@2|Bacteria,1TR32@1239|Firmicutes,249TG@186801|Clostridia,36EMS@31979|Clostridiaceae	186801|Clostridia	T	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
HKD2_k127_1662710_10	913865.DOT_4485	1.377e-43	166.0	COG0454@1|root,COG0454@2|Bacteria,COG0456@2|Bacteria,1VDKW@1239|Firmicutes,24HZW@186801|Clostridia	186801|Clostridia	K	PFAM Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HKD2_k127_1666604_3	1321778.HMPREF1982_02616	1.328e-71	247.0	COG1721@1|root,COG1721@2|Bacteria,1V2UW@1239|Firmicutes,24AGA@186801|Clostridia	186801|Clostridia	S	protein some members contain a von Willebrand factor type A	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
HKD2_k127_1666604_1	1540257.JQMW01000013_gene1234	7.065e-129	433.0	COG2304@1|root,COG2304@2|Bacteria,1V0C8@1239|Firmicutes,249ZD@186801|Clostridia,36E6D@31979|Clostridiaceae	186801|Clostridia	S	Aerotolerance regulator N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	BatA,VWA_2
HKD2_k127_1666604_0	1195236.CTER_1806	7.725e-292	922.0	COG2304@1|root,COG5426@1|root,COG2304@2|Bacteria,COG5426@2|Bacteria,1TQXZ@1239|Firmicutes,249E6@186801|Clostridia	186801|Clostridia	S	von Willebrand factor, type A	-	-	-	-	-	-	-	-	-	-	-	-	BatA,GATase1_like,VWA,VWA_2,VWA_3
HKD2_k127_1666604_2	509191.AEDB02000034_gene2268	5.934e-89	299.0	COG0356@1|root,COG0356@2|Bacteria,1TQIT@1239|Firmicutes,24A6Q@186801|Clostridia,3WIAV@541000|Ruminococcaceae	186801|Clostridia	C	it plays a direct role in the translocation of protons across the membrane	atpB	-	-	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1	-	-	ATP-synt_A
HKD2_k127_1666604_7	509191.AEDB02000034_gene2267	1.933e-18	87.0	COG0636@1|root,COG0636@2|Bacteria,1V8SD@1239|Firmicutes,24QMQ@186801|Clostridia,3WKSD@541000|Ruminococcaceae	186801|Clostridia	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpE	-	-	ko:K02110	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	iHN637.CLJU_RS01165	ATP-synt_C
HKD2_k127_1666604_6	203119.Cthe_2604	1.326e-38	149.0	COG0711@1|root,COG0711@2|Bacteria,1VB85@1239|Firmicutes,24RWR@186801|Clostridia,3WIRW@541000|Ruminococcaceae	186801|Clostridia	C	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)	atpF	-	-	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_B
HKD2_k127_1666604_5	398512.JQKC01000002_gene2000	8.313e-42	160.0	COG0712@1|root,COG0712@2|Bacteria,1VAG3@1239|Firmicutes,24MSA@186801|Clostridia,3WJDH@541000|Ruminococcaceae	186801|Clostridia	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpH	-	-	ko:K02113	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	OSCP
HKD2_k127_1666604_4	398512.JQKC01000002_gene2001	2.229e-56	199.0	COG0056@1|root,COG0056@2|Bacteria,1TNZ8@1239|Firmicutes,248IY@186801|Clostridia,3WGXD@541000|Ruminococcaceae	186801|Clostridia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	atpA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
HKD2_k127_1698286_5	1304284.L21TH_0540	1.604e-105	352.0	COG1307@1|root,COG1307@2|Bacteria,1TRM7@1239|Firmicutes,248N9@186801|Clostridia,36VJR@31979|Clostridiaceae	186801|Clostridia	S	Uncharacterised protein, DegV family COG1307	-	-	-	-	-	-	-	-	-	-	-	-	DegV
HKD2_k127_1698286_4	555079.Toce_0514	1.151e-106	355.0	COG1453@1|root,COG1453@2|Bacteria,1TSTA@1239|Firmicutes,249IP@186801|Clostridia	186801|Clostridia	C	aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red,Fer4,Fer4_17
HKD2_k127_1698286_0	536227.CcarbDRAFT_0344	2.25e-207	653.0	COG0531@1|root,COG0531@2|Bacteria,1TSSB@1239|Firmicutes,25B81@186801|Clostridia,36WAW@31979|Clostridiaceae	186801|Clostridia	E	amino acid	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
HKD2_k127_1698286_1	1304284.L21TH_1665	8.195e-203	638.0	COG1388@1|root,COG3858@1|root,COG1388@2|Bacteria,COG3858@2|Bacteria,1TQK2@1239|Firmicutes,247YF@186801|Clostridia,36E8N@31979|Clostridiaceae	186801|Clostridia	M	family 18	-	-	-	ko:K06306	-	-	-	-	ko00000	-	-	-	Glyco_hydro_18,LysM
HKD2_k127_1698286_2	941824.TCEL_02126	5.004e-192	610.0	COG1502@1|root,COG1502@2|Bacteria,1TPKY@1239|Firmicutes,247UR@186801|Clostridia,36EA0@31979|Clostridiaceae	186801|Clostridia	I	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol	cls	-	-	ko:K06131	ko00564,ko01100,map00564,map01100	-	R07390	RC00017	ko00000,ko00001,ko01000	-	-	-	PLDc_2,PLDc_N
HKD2_k127_1698286_3	857293.CAAU_1774	3.861e-107	357.0	COG1752@1|root,COG1752@2|Bacteria,1UBYN@1239|Firmicutes,247V3@186801|Clostridia,36WRU@31979|Clostridiaceae	186801|Clostridia	S	Patatin-like phospholipase	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
HKD2_k127_1753744_1	641107.CDLVIII_1395	3.718e-122	400.0	COG0358@1|root,COG0358@2|Bacteria,1TQ0X@1239|Firmicutes,2480W@186801|Clostridia,36FK8@31979|Clostridiaceae	186801|Clostridia	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2
HKD2_k127_1753744_2	1408422.JHYF01000002_gene2470	5.04e-34	136.0	COG1671@1|root,COG1671@2|Bacteria,1V9Z0@1239|Firmicutes,24HPW@186801|Clostridia,36J4K@31979|Clostridiaceae	186801|Clostridia	S	Belongs to the UPF0178 family	-	-	-	ko:K09768	-	-	-	-	ko00000	-	-	-	DUF188
HKD2_k127_1753744_0	696369.KI912183_gene119	4.56e-137	443.0	COG0232@1|root,COG0232@2|Bacteria,1TPEI@1239|Firmicutes,247Q1@186801|Clostridia,26088@186807|Peptococcaceae	186801|Clostridia	F	Deoxyguanosinetriphosphate triphosphohydrolase	dgt	-	3.1.5.1	ko:K01129	ko00230,map00230	-	R01856	RC00017	ko00000,ko00001,ko01000	-	-	-	HD,HD_assoc
HKD2_k127_1755667_1	273068.TTE1298	6.696e-97	324.0	COG1154@1|root,COG1154@2|Bacteria,1TP37@1239|Firmicutes,247P1@186801|Clostridia,42EPX@68295|Thermoanaerobacterales	186801|Clostridia	H	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)	dxs	-	2.2.1.7	ko:K01662	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	M00096	R05636	RC00032	ko00000,ko00001,ko00002,ko01000	-	-	-	DXP_synthase_N,Transket_pyr,Transketolase_C
HKD2_k127_1755667_0	457396.CSBG_01312	1.494e-108	357.0	COG1189@1|root,COG1189@2|Bacteria,1TPE4@1239|Firmicutes,247VH@186801|Clostridia,36EDU@31979|Clostridiaceae	186801|Clostridia	J	Methyltransferase	rrmJ	-	2.1.1.226,2.1.1.227	ko:K06442	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ,S4
HKD2_k127_1755667_2	2325.TKV_c12160	2.119e-92	311.0	COG0061@1|root,COG0061@2|Bacteria,1TRB3@1239|Firmicutes,24BG6@186801|Clostridia,42FQN@68295|Thermoanaerobacterales	186801|Clostridia	F	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	nadK	-	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	iHN637.CLJU_RS05480	NAD_kinase
HKD2_k127_1763029_6	203119.Cthe_1246	8.286e-49	176.0	COG0138@1|root,COG0138@2|Bacteria,1TPQ5@1239|Firmicutes,24AB8@186801|Clostridia,3WHMW@541000|Ruminococcaceae	186801|Clostridia	F	Bifunctional purine biosynthesis protein PurH	purH	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iHN637.CLJU_RS04230	AICARFT_IMPCHas,MGS
HKD2_k127_1763029_5	580331.Thit_0575	9.469e-62	219.0	COG0299@1|root,COG0299@2|Bacteria,1V3RJ@1239|Firmicutes,249JC@186801|Clostridia,42FSV@68295|Thermoanaerobacterales	186801|Clostridia	F	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate	purN	-	2.1.2.2	ko:K11175	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	M00048	R04325,R04326	RC00026,RC00197,RC01128	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS04225	Formyl_trans_N
HKD2_k127_1763029_2	1304284.L21TH_1809	1.094e-134	437.0	COG0150@1|root,COG0150@2|Bacteria,1TP9J@1239|Firmicutes,248BT@186801|Clostridia,36F1W@31979|Clostridiaceae	186801|Clostridia	F	Phosphoribosylformylglycinamidine cyclo-ligase	purM	-	6.3.3.1	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04208	RC01100	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
HKD2_k127_1763029_1	938288.HG326230_gene22	5.288e-160	517.0	COG0034@1|root,COG0034@2|Bacteria,1TPH3@1239|Firmicutes,247RF@186801|Clostridia,2685T@186813|unclassified Clostridiales	186801|Clostridia	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	-	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_6,GATase_7,Pribosyltran
HKD2_k127_1763029_3	1094508.Tsac_2582	2.44e-100	332.0	COG0152@1|root,COG0152@2|Bacteria,1TP11@1239|Firmicutes,2483I@186801|Clostridia,42F0B@68295|Thermoanaerobacterales	186801|Clostridia	F	PFAM SAICAR synthetase	purC	-	4.3.2.2,6.3.2.6	ko:K01756,ko:K01923	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559,R04591	RC00064,RC00162,RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	-	SAICAR_synt
HKD2_k127_1763029_4	1121335.Clst_2030	1.243e-62	219.0	COG0041@1|root,COG0041@2|Bacteria,1V1MV@1239|Firmicutes,24HCB@186801|Clostridia,3WITM@541000|Ruminococcaceae	186801|Clostridia	F	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)	purE	-	5.4.99.18	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07405	RC01947	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRC
HKD2_k127_1763029_0	720554.Clocl_2589	9.429e-267	837.0	COG0046@1|root,COG0047@1|root,COG0046@2|Bacteria,COG0047@2|Bacteria,1TPAS@1239|Firmicutes,247W2@186801|Clostridia,3WGRN@541000|Ruminococcaceae	186801|Clostridia	F	phosphoribosylformylglycinamidine synthase	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C,GATase_5
HKD2_k127_1776119_5	1230342.CTM_09651	4.817e-63	220.0	COG3580@1|root,COG3580@2|Bacteria,1TR03@1239|Firmicutes,24987@186801|Clostridia,36DX9@31979|Clostridiaceae	186801|Clostridia	I	CoA enzyme activase uncharacterised domain (DUF2229)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2229
HKD2_k127_1776119_2	1408422.JHYF01000009_gene2018	5.858e-129	422.0	COG1473@1|root,COG1473@2|Bacteria,1TPD7@1239|Firmicutes,248AH@186801|Clostridia,36DRG@31979|Clostridiaceae	186801|Clostridia	E	amidohydrolase	dapL	-	3.5.1.47	ko:K05823	ko00300,ko01100,ko01110,ko01230,map00300,map01100,map01110,map01230	M00525	R02733	RC00064,RC00300	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20
HKD2_k127_1776119_0	509191.AEDB02000108_gene1539	1.258e-164	523.0	COG0136@1|root,COG0136@2|Bacteria,1TPC6@1239|Firmicutes,248ZR@186801|Clostridia,3WGVU@541000|Ruminococcaceae	186801|Clostridia	E	Belongs to the aspartate-semialdehyde dehydrogenase family	asd	-	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
HKD2_k127_1776119_1	935948.KE386494_gene415	1.824e-134	434.0	COG0329@1|root,COG0329@2|Bacteria,1TPCK@1239|Firmicutes,247T5@186801|Clostridia,42FSY@68295|Thermoanaerobacterales	186801|Clostridia	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	dapA	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS02100	DHDPS
HKD2_k127_1776119_4	1499684.CCNP01000020_gene2495	1.423e-86	293.0	COG0289@1|root,COG0289@2|Bacteria,1TR9D@1239|Firmicutes,248FY@186801|Clostridia,36DQC@31979|Clostridiaceae	186801|Clostridia	E	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate	dapB	-	1.17.1.8	ko:K00215	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R04198,R04199	RC00478	ko00000,ko00001,ko00002,ko01000	-	-	-	DapB_C,DapB_N
HKD2_k127_1776119_3	857293.CAAU_0470	4.418e-95	316.0	COG2171@1|root,COG2171@2|Bacteria,1TQUJ@1239|Firmicutes,248RU@186801|Clostridia,36DIF@31979|Clostridiaceae	186801|Clostridia	E	Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate	dapH	-	2.3.1.117,2.3.1.89	ko:K00674,ko:K05822	ko00300,ko01100,ko01110,ko01120,ko01230,map00300,map01100,map01110,map01120,map01230	M00016,M00525	R04364,R04365	RC00004,RC01136	ko00000,ko00001,ko00002,ko01000	-	-	-	DapH_N,Hexapep
HKD2_k127_1776119_6	1227360.C176_18582	1.64e-40	156.0	COG3153@1|root,COG3153@2|Bacteria,1V3PW@1239|Firmicutes,4HGZK@91061|Bacilli,26FEG@186818|Planococcaceae	91061|Bacilli	S	Acetyltransferase (GNAT) domain	-	-	-	ko:K03824	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_1,Acetyltransf_9
HKD2_k127_1778141_1	279010.BL02334	3.493e-196	626.0	COG1263@1|root,COG1264@1|root,COG2190@1|root,COG1263@2|Bacteria,COG1264@2|Bacteria,COG2190@2|Bacteria,1TP5X@1239|Firmicutes,4HC6P@91061|Bacilli,1ZCN5@1386|Bacillus	91061|Bacilli	G	phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1	-	-	-	ko:K02755,ko:K02756,ko:K02757	ko02060,map02060	M00271	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.1.2.11,4.A.1.2.2,4.A.1.2.5,4.A.1.2.6	-	-	PTS_EIIA_1,PTS_EIIB,PTS_EIIC
HKD2_k127_1778141_0	457396.CSBG_00805	4.84e-234	732.0	COG2723@1|root,COG2723@2|Bacteria,1TP19@1239|Firmicutes,2485V@186801|Clostridia,36DZU@31979|Clostridiaceae	186801|Clostridia	G	Belongs to the glycosyl hydrolase 1 family	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_1
HKD2_k127_1778141_2	1415774.U728_207	1.984e-96	322.0	COG3711@1|root,COG3711@2|Bacteria,1TT5A@1239|Firmicutes,24931@186801|Clostridia,36E2H@31979|Clostridiaceae	186801|Clostridia	K	transcriptional antiterminator	licT	-	-	ko:K03488	-	-	-	-	ko00000,ko03000	-	-	-	CAT_RBD,PRD
HKD2_k127_1778141_3	1111454.HMPREF1250_0067	1.58e-25	108.0	28H7K@1|root,2Z7JT@2|Bacteria,1UPH1@1239|Firmicutes,4H7IY@909932|Negativicutes	909932|Negativicutes	P	2-keto-3-deoxygluconate permease	-	-	-	ko:K02526	-	-	-	-	ko00000,ko02000	2.A.10.1	-	-	KdgT
HKD2_k127_1786846_2	1304284.L21TH_0931	3.052e-135	438.0	COG1453@1|root,COG1453@2|Bacteria,1TQ5N@1239|Firmicutes,247SD@186801|Clostridia,36F1U@31979|Clostridiaceae	186801|Clostridia	C	aldo keto reductase	-	-	-	ko:K07079	-	-	-	-	ko00000	-	-	-	Aldo_ket_red,Fer4_17
HKD2_k127_1786846_1	1304880.JAGB01000001_gene960	2.252e-275	863.0	COG0480@1|root,COG0480@2|Bacteria,1TPWN@1239|Firmicutes,247N4@186801|Clostridia	186801|Clostridia	J	elongation factor g	fusA2	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
HKD2_k127_1786846_6	1408422.JHYF01000020_gene1818	6.247e-07	53.0	2ERBM@1|root,33IX9@2|Bacteria,1VP9A@1239|Firmicutes	1239|Firmicutes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1786846_5	1033737.CAEV01000065_gene2779	8.887e-42	158.0	COG4463@1|root,COG4463@2|Bacteria,1VAXT@1239|Firmicutes,24JH3@186801|Clostridia,36JKR@31979|Clostridiaceae	186801|Clostridia	K	Belongs to the CtsR family	ctsR	-	-	ko:K03708	-	-	-	-	ko00000,ko03000	-	-	-	CtsR
HKD2_k127_1786846_4	1304284.L21TH_1313	1.963e-49	182.0	COG3880@1|root,COG3880@2|Bacteria,1V6YM@1239|Firmicutes,24JE8@186801|Clostridia,36IPM@31979|Clostridiaceae	186801|Clostridia	S	PFAM UvrB uvrC	mcsA	-	-	ko:K19411	-	-	-	-	ko00000	-	-	-	UVR
HKD2_k127_1786846_3	1356854.N007_07610	3.122e-111	369.0	COG3869@1|root,COG3869@2|Bacteria,1TPBA@1239|Firmicutes,4HC6U@91061|Bacilli,2791S@186823|Alicyclobacillaceae	91061|Bacilli	E	Catalyzes the specific phosphorylation of arginine residues in proteins	mcsB	GO:0006950,GO:0008150,GO:0010035,GO:0010038,GO:0042221,GO:0046686,GO:0046688,GO:0050896,GO:0097501,GO:1990169,GO:1990170	2.7.14.1	ko:K19405	-	-	R11090	RC00002,RC00203	ko00000,ko01000	-	-	-	ATP-gua_Ptrans
HKD2_k127_1786846_0	935948.KE386495_gene1543	1.632e-302	939.0	COG0542@1|root,COG0542@2|Bacteria,1TPMU@1239|Firmicutes,247TD@186801|Clostridia,42FKB@68295|Thermoanaerobacterales	186801|Clostridia	O	Belongs to the ClpA ClpB family	clpC	-	-	ko:K03696	ko01100,map01100	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N,UVR
HKD2_k127_1796700_0	1321778.HMPREF1982_01749	6.672e-142	452.0	COG2013@1|root,COG2013@2|Bacteria,1TP7N@1239|Firmicutes,249B4@186801|Clostridia,2699M@186813|unclassified Clostridiales	186801|Clostridia	S	Mitochondrial biogenesis AIM24	-	-	-	-	-	-	-	-	-	-	-	-	AIM24
HKD2_k127_1796700_2	1196322.A370_00317	1.784e-96	335.0	COG2199@1|root,COG2199@2|Bacteria,1TQ2X@1239|Firmicutes,25BXT@186801|Clostridia,36WJM@31979|Clostridiaceae	186801|Clostridia	T	Diguanylate cyclase (GGDEF) domain	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,HisKA_7TM,PAS_9
HKD2_k127_1796700_3	592027.CLG_B0424	2.904e-78	266.0	COG0503@1|root,COG0503@2|Bacteria,1V1DU@1239|Firmicutes,249VC@186801|Clostridia,36E9V@31979|Clostridiaceae	186801|Clostridia	F	Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis	xpt	-	2.4.2.22	ko:K03816	ko00230,ko01100,ko01110,map00230,map01100,map01110	-	R01229,R02142	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	Pribosyltran
HKD2_k127_1796700_1	1449126.JQKL01000020_gene3319	6.282e-132	427.0	COG1744@1|root,COG1744@2|Bacteria,1TPEU@1239|Firmicutes,248IH@186801|Clostridia,268EB@186813|unclassified Clostridiales	186801|Clostridia	S	ABC transporter substrate-binding protein PnrA-like	-	-	-	ko:K07335	-	-	-	-	ko00000	-	-	-	Bmp
HKD2_k127_1817140_3	1286171.EAL2_808p03650	1.838e-11	64.0	COG0450@1|root,COG0450@2|Bacteria,1TQU7@1239|Firmicutes,24A31@186801|Clostridia,25W5Y@186806|Eubacteriaceae	186801|Clostridia	O	C-terminal domain of 1-Cys peroxiredoxin	ahpC	-	1.11.1.15	ko:K03386	ko04214,map04214	-	-	-	ko00000,ko00001,ko01000,ko04147	-	-	-	1-cysPrx_C,AhpC-TSA
HKD2_k127_1817140_4	485916.Dtox_2806	1.235e-10	63.0	COG0450@1|root,COG0450@2|Bacteria,1TQU7@1239|Firmicutes,24A31@186801|Clostridia,262HH@186807|Peptococcaceae	186801|Clostridia	O	Peroxiredoxin	ahpC	-	1.11.1.15	ko:K03386	ko04214,map04214	-	-	-	ko00000,ko00001,ko01000,ko04147	-	-	-	1-cysPrx_C,AhpC-TSA
HKD2_k127_1817140_2	350688.Clos_1340	3.502e-54	199.0	COG0494@1|root,COG0494@2|Bacteria,1V6SF@1239|Firmicutes,24HCG@186801|Clostridia,36IWP@31979|Clostridiaceae	186801|Clostridia	L	pfam nudix	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
HKD2_k127_1817140_0	1408422.JHYF01000016_gene123	1.388e-165	526.0	COG0075@1|root,COG0075@2|Bacteria,1TPS0@1239|Firmicutes,24919@186801|Clostridia,36E72@31979|Clostridiaceae	186801|Clostridia	E	Aminotransferase	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
HKD2_k127_1817140_1	1410668.JNKC01000007_gene773	3.032e-72	246.0	COG0111@1|root,COG0111@2|Bacteria,1V410@1239|Firmicutes,248H9@186801|Clostridia,36DCU@31979|Clostridiaceae	186801|Clostridia	EH	D-isomer specific 2-hydroxyacid dehydrogenase	serA	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
HKD2_k127_1825661_6	398512.JQKC01000011_gene344	4.22e-33	136.0	2E6BB@1|root,330Z5@2|Bacteria,1VF3M@1239|Firmicutes,24RAX@186801|Clostridia,3WM04@541000|Ruminococcaceae	186801|Clostridia	S	Stage III sporulation protein AG	spoIIIAG	-	-	ko:K06396	-	-	-	-	ko00000	-	-	-	-
HKD2_k127_1825661_8	697281.Mahau_0780	6.792e-18	91.0	2E3US@1|root,32YS3@2|Bacteria,1VESK@1239|Firmicutes,24R9H@186801|Clostridia,42H58@68295|Thermoanaerobacterales	186801|Clostridia	S	SpoIIIAH-like protein	spoIIIAH	-	-	ko:K06397	-	-	-	-	ko00000	1.A.34.1.1	-	-	SpoIIIAH
HKD2_k127_1825661_5	1094508.Tsac_1930	3.767e-47	173.0	COG1302@1|root,COG1302@2|Bacteria,1V4IC@1239|Firmicutes,24JNM@186801|Clostridia,42GHU@68295|Thermoanaerobacterales	186801|Clostridia	S	Asp23 family, cell envelope-related function	asp	-	-	-	-	-	-	-	-	-	-	-	Asp23
HKD2_k127_1825661_7	1121335.Clst_2156	2.12e-32	131.0	COG0781@1|root,COG0781@2|Bacteria,1VA9B@1239|Firmicutes,24MQ3@186801|Clostridia,3WK9U@541000|Ruminococcaceae	186801|Clostridia	K	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons	nusB	-	-	ko:K03625	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	NusB
HKD2_k127_1825661_3	1304880.JAGB01000001_gene98	1.261e-70	251.0	COG0533@1|root,COG0533@2|Bacteria,1TRPY@1239|Firmicutes,24CN4@186801|Clostridia	186801|Clostridia	O	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction	gcp1	-	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
HKD2_k127_1825661_1	398512.JQKC01000011_gene338	3.112e-114	381.0	COG1570@1|root,COG1570@2|Bacteria,1TP4E@1239|Firmicutes,247KE@186801|Clostridia,3WGCP@541000|Ruminococcaceae	186801|Clostridia	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseA	-	3.1.11.6	ko:K03601	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_L,tRNA_anti_2
HKD2_k127_1825661_9	1220551.SCHR_04390	1.112e-10	64.0	COG1722@1|root,COG1722@2|Bacteria,1VK9I@1239|Firmicutes,4HRGZ@91061|Bacilli,4GZY5@90964|Staphylococcaceae	91061|Bacilli	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseB	-	3.1.11.6	ko:K03602	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_S
HKD2_k127_1825661_2	394503.Ccel_1902	3.158e-87	297.0	COG0142@1|root,COG0142@2|Bacteria,1TPQY@1239|Firmicutes,248DE@186801|Clostridia,36EGM@31979|Clostridiaceae	186801|Clostridia	H	Belongs to the FPP GGPP synthase family	ispA	-	2.5.1.1,2.5.1.10,2.5.1.29	ko:K13789	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00366	R01658,R02003,R02061	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	iHN637.CLJU_RS05465	polyprenyl_synt
HKD2_k127_1825661_4	1511.CLOST_1344	1.238e-50	183.0	COG1963@1|root,COG1963@2|Bacteria,1VAVC@1239|Firmicutes,24MV7@186801|Clostridia,25RHI@186804|Peptostreptococcaceae	186801|Clostridia	S	Divergent PAP2 family	-	-	-	ko:K09775	-	-	-	-	ko00000	-	-	-	DUF212
HKD2_k127_1825661_0	1304284.L21TH_0188	4.398e-153	492.0	COG1154@1|root,COG1154@2|Bacteria,1TP37@1239|Firmicutes,247P1@186801|Clostridia,36DZY@31979|Clostridiaceae	186801|Clostridia	H	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)	dxs	-	2.2.1.7	ko:K01662	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	M00096	R05636	RC00032	ko00000,ko00001,ko00002,ko01000	-	-	-	DXP_synthase_N,Transket_pyr,Transketolase_C
HKD2_k127_186858_12	500635.MITSMUL_05556	9.38e-57	203.0	COG0743@1|root,COG0743@2|Bacteria,1TP1C@1239|Firmicutes,4H2Q8@909932|Negativicutes	909932|Negativicutes	I	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)	dxr	-	1.1.1.267	ko:K00099	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05688	RC01452	ko00000,ko00001,ko00002,ko01000	-	-	-	DXPR_C,DXP_redisom_C,DXP_reductoisom
HKD2_k127_186858_11	1121342.AUCO01000001_gene2010	7.209e-60	216.0	COG0575@1|root,COG0575@2|Bacteria,1UPNB@1239|Firmicutes,248BP@186801|Clostridia,36E6I@31979|Clostridiaceae	186801|Clostridia	I	Belongs to the CDS family	cdsA	-	2.7.7.41	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_1
HKD2_k127_186858_6	273068.TTE1404	1.194e-95	318.0	COG0020@1|root,COG0020@2|Bacteria,1TQTS@1239|Firmicutes,247TE@186801|Clostridia,42F7X@68295|Thermoanaerobacterales	186801|Clostridia	H	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids	uppS	-	2.5.1.31	ko:K00806	ko00900,ko01110,map00900,map01110	-	R06447	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
HKD2_k127_186858_10	273068.TTE1406	2.109e-69	239.0	COG0233@1|root,COG0233@2|Bacteria,1V1F2@1239|Firmicutes,24HWS@186801|Clostridia,42FRZ@68295|Thermoanaerobacterales	186801|Clostridia	J	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another	frr	-	-	ko:K02838	-	-	-	-	ko00000,ko03012	-	-	-	RRF
HKD2_k127_186858_3	509191.AEDB02000108_gene1596	4.365e-112	366.0	COG0528@1|root,COG0528@2|Bacteria,1TPXN@1239|Firmicutes,247KR@186801|Clostridia,3WGUN@541000|Ruminococcaceae	186801|Clostridia	F	Catalyzes the reversible phosphorylation of UMP to UDP	pyrH	-	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
HKD2_k127_186858_5	203119.Cthe_1005	2.373e-96	319.0	COG0264@1|root,COG0264@2|Bacteria,1TPFJ@1239|Firmicutes,248J2@186801|Clostridia,3WGCR@541000|Ruminococcaceae	186801|Clostridia	J	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome	tsf	-	-	ko:K02357	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EF_TS
HKD2_k127_186858_2	398512.JQKC01000009_gene515	1.937e-119	387.0	COG0052@1|root,COG0052@2|Bacteria,1TPNA@1239|Firmicutes,247ZR@186801|Clostridia,3WGT4@541000|Ruminococcaceae	186801|Clostridia	J	Belongs to the universal ribosomal protein uS2 family	rpsB	-	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
HKD2_k127_186858_14	1511.CLOST_1091	4.037e-08	61.0	COG1559@1|root,COG1559@2|Bacteria,1VZ75@1239|Firmicutes,25HWE@186801|Clostridia,25UDY@186804|Peptostreptococcaceae	186801|Clostridia	S	periplasmic solute-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	YceG
HKD2_k127_186858_15	1291050.JAGE01000001_gene169	1.369e-07	60.0	2EENM@1|root,338GG@2|Bacteria,1VINB@1239|Firmicutes,24TE5@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_186858_1	720554.Clocl_1935	7.982e-130	436.0	COG1315@1|root,COG1315@2|Bacteria,1TR7W@1239|Firmicutes,24B18@186801|Clostridia,3WH6E@541000|Ruminococcaceae	186801|Clostridia	L	Flagellar Assembly Protein A	-	-	-	ko:K09749	-	-	-	-	ko00000	-	-	-	FapA
HKD2_k127_186858_7	1121335.Clst_0690	5.308e-81	276.0	COG1191@1|root,COG1191@2|Bacteria,1TP9K@1239|Firmicutes,248M0@186801|Clostridia,3WJ7A@541000|Ruminococcaceae	186801|Clostridia	K	TIGRFAM RNA polymerase sigma factor, FliA WhiG family	fliA	-	-	ko:K02405	ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111	-	-	-	ko00000,ko00001,ko02035,ko03021	-	-	-	Sigma70_r2,Sigma70_r3,Sigma70_r4
HKD2_k127_186858_9	1291050.JAGE01000001_gene174	1.163e-69	239.0	COG1871@1|root,COG1871@2|Bacteria,1V70X@1239|Firmicutes,24HH7@186801|Clostridia,3WKBQ@541000|Ruminococcaceae	186801|Clostridia	NT	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis	cheD	-	3.5.1.44	ko:K03411	ko02030,map02030	-	-	-	ko00000,ko00001,ko01000,ko02035	-	-	-	CheD
HKD2_k127_186858_8	293826.Amet_2696	5.046e-74	254.0	COG1776@1|root,COG1776@2|Bacteria,1UNKB@1239|Firmicutes,247MX@186801|Clostridia,36H30@31979|Clostridiaceae	186801|Clostridia	NT	chemotaxis protein	cheC	-	-	ko:K03410	ko02030,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheC
HKD2_k127_186858_13	1209989.TepiRe1_1356	3.584e-43	163.0	COG0835@1|root,COG0835@2|Bacteria,1V4HH@1239|Firmicutes,24JV4@186801|Clostridia,42GKD@68295|Thermoanaerobacterales	186801|Clostridia	NT	PFAM CheW domain protein	-	-	-	ko:K03408	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheW
HKD2_k127_186858_0	273068.TTE1417	1.396e-209	670.0	COG0643@1|root,COG2198@1|root,COG0643@2|Bacteria,COG2198@2|Bacteria,1TPMS@1239|Firmicutes,24858@186801|Clostridia,42END@68295|Thermoanaerobacterales	186801|Clostridia	T	Signal transducing histidine kinase, homodimeric	cheA	-	2.7.13.3	ko:K03407	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt,P2
HKD2_k127_186858_4	293826.Amet_2699	4.535e-105	351.0	COG2201@1|root,COG2201@2|Bacteria,1TRHC@1239|Firmicutes,249FD@186801|Clostridia,36EIW@31979|Clostridiaceae	186801|Clostridia	NT	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR	cheB	-	3.1.1.61,3.5.1.44	ko:K03412	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest,Response_reg
HKD2_k127_186858_16	1121289.JHVL01000003_gene2205	2.496e-05	49.0	COG5581@1|root,COG5581@2|Bacteria,1VERW@1239|Firmicutes	1239|Firmicutes	M	PFAM Type IV pilus assembly PilZ	pilZ	-	-	-	-	-	-	-	-	-	-	-	PilZ,YcgR_2
HKD2_k127_1869188_5	1121422.AUMW01000033_gene3386	1.126e-05	49.0	COG1142@1|root,COG4624@1|root,COG1142@2|Bacteria,COG4624@2|Bacteria,1TQIR@1239|Firmicutes,248BS@186801|Clostridia,260NM@186807|Peptococcaceae	186801|Clostridia	C	PFAM Iron only hydrogenase large subunit, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Fe_hyd_lg_C,Fer4
HKD2_k127_1869188_2	720554.Clocl_3025	7.08e-93	316.0	28HHD@1|root,2Z7T3@2|Bacteria,1TRKJ@1239|Firmicutes,24A0Y@186801|Clostridia,3WI6G@541000|Ruminococcaceae	186801|Clostridia	S	Protein of unknown function (DUF3810)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3810
HKD2_k127_1869188_0	931626.Awo_c32170	0.0	1515.0	COG0574@1|root,COG3848@1|root,COG0574@2|Bacteria,COG3848@2|Bacteria,1UIEA@1239|Firmicutes,25EJM@186801|Clostridia,25ZUT@186806|Eubacteriaceae	186801|Clostridia	H	Pyruvate phosphate dikinase, PEP/pyruvate binding domain	ppdK	-	2.7.9.1,2.7.9.2	ko:K01006,ko:K01007	ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173,M00374	R00199,R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
HKD2_k127_1869188_1	459349.CLOAM1530	1.789e-165	529.0	COG0057@1|root,COG0057@2|Bacteria,2NNPP@2323|unclassified Bacteria	2|Bacteria	G	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family	-	-	1.2.1.12,1.2.1.59,1.4.1.16	ko:K00134,ko:K00150,ko:K03340	ko00010,ko00300,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00300,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00526,M00552	R01061,R01063,R02755	RC00006,RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	DapB_N,Gp_dh_C,Gp_dh_N
HKD2_k127_1869188_4	1121324.CLIT_10c03170	5.297e-66	233.0	COG2843@1|root,COG2843@2|Bacteria,1V20N@1239|Firmicutes,24AI2@186801|Clostridia	186801|Clostridia	M	D-alanyl-D-alanine carboxypeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M15_4
HKD2_k127_1869188_3	1304284.L21TH_0721	2.39e-86	293.0	COG0312@1|root,COG0312@2|Bacteria,1V3G5@1239|Firmicutes,249ZM@186801|Clostridia,36DH9@31979|Clostridiaceae	186801|Clostridia	S	Putative modulator of DNA gyrase	-	-	-	ko:K03592	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
HKD2_k127_188183_8	340099.Teth39_0215	0.0002033	46.0	COG1387@1|root,COG1796@1|root,COG1387@2|Bacteria,COG1796@2|Bacteria,1TQ33@1239|Firmicutes,249TZ@186801|Clostridia,42FCI@68295|Thermoanaerobacterales	186801|Clostridia	L	DNA polymerase	polX	-	-	ko:K02347	-	-	-	-	ko00000,ko03400	-	-	-	DNA_pol_B_palm,DNA_pol_B_thumb,HHH_5,HHH_8,PHP
HKD2_k127_188183_4	720554.Clocl_2251	1.162e-84	286.0	COG0177@1|root,COG0177@2|Bacteria,1TRAK@1239|Firmicutes,24899@186801|Clostridia,3WGWR@541000|Ruminococcaceae	186801|Clostridia	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD
HKD2_k127_188183_2	720554.Clocl_0114	2.832e-151	499.0	COG1269@1|root,COG1269@2|Bacteria,1TPTE@1239|Firmicutes,249YV@186801|Clostridia,3WHFQ@541000|Ruminococcaceae	186801|Clostridia	C	Belongs to the V-ATPase 116 kDa subunit family	ntpI	-	-	ko:K02123	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	V_ATPase_I
HKD2_k127_188183_5	720554.Clocl_0113	1.917e-49	181.0	COG0636@1|root,COG0636@2|Bacteria,1V786@1239|Firmicutes,24HBF@186801|Clostridia,3WJD9@541000|Ruminococcaceae	186801|Clostridia	C	ATP synthase subunit C	ntpK	-	-	ko:K02124	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_C
HKD2_k127_188183_6	509191.AEDB02000049_gene4412	9.873e-42	160.0	COG1390@1|root,COG1390@2|Bacteria,1VEEA@1239|Firmicutes,24QMH@186801|Clostridia,3WRW5@541000|Ruminococcaceae	186801|Clostridia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpE	-	-	ko:K02121	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	vATP-synt_E
HKD2_k127_188183_3	720554.Clocl_0111	1.872e-88	303.0	COG1527@1|root,COG1527@2|Bacteria,1U6WZ@1239|Firmicutes,249XD@186801|Clostridia,3WJ1X@541000|Ruminococcaceae	186801|Clostridia	C	ATP synthase (C/AC39) subunit	ntpC	-	-	ko:K02119	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	vATP-synt_AC39
HKD2_k127_188183_7	1280689.AUJC01000001_gene2120	9.994e-34	132.0	COG1436@1|root,COG1436@2|Bacteria,1VAX7@1239|Firmicutes,24MXC@186801|Clostridia,36JRX@31979|Clostridiaceae	186801|Clostridia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpF	-	-	ko:K02122	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_F
HKD2_k127_188183_0	1304880.JAGB01000002_gene2361	1.194e-285	886.0	COG1155@1|root,COG1155@2|Bacteria,1TPGS@1239|Firmicutes,24882@186801|Clostridia	186801|Clostridia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit	-	-	3.6.3.14,3.6.3.15	ko:K02117	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002,ko01000	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn
HKD2_k127_188183_1	1031288.AXAA01000009_gene671	1.454e-224	698.0	COG1156@1|root,COG1156@2|Bacteria,1VSU1@1239|Firmicutes,2496H@186801|Clostridia,36DRP@31979|Clostridiaceae	186801|Clostridia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit	atpB	-	-	ko:K02118	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N
HKD2_k127_1887351_3	398512.JQKC01000011_gene316	8.357e-244	767.0	COG0860@1|root,COG1649@1|root,COG0860@2|Bacteria,COG1649@2|Bacteria,1TRTG@1239|Firmicutes,24B2F@186801|Clostridia,3WGB4@541000|Ruminococcaceae	186801|Clostridia	M	lipoprotein YddW precursor K01189	-	-	-	-	-	-	-	-	-	-	-	-	Amidase_3,Big_2,GHL10
HKD2_k127_1887351_11	509191.AEDB02000022_gene3011	3.49e-71	248.0	arCOG03165@1|root,30AIC@2|Bacteria,1V7NB@1239|Firmicutes,24M5X@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1887351_1	350688.Clos_0658	3.301e-306	947.0	COG1164@1|root,COG1164@2|Bacteria,1TR7D@1239|Firmicutes,25CE2@186801|Clostridia,36HBI@31979|Clostridiaceae	186801|Clostridia	E	Oligopeptidase F	pepF	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M3,Peptidase_M3_N
HKD2_k127_1887351_13	1487921.DP68_03455	1.374e-57	206.0	2C2FW@1|root,32RAE@2|Bacteria,1V7TJ@1239|Firmicutes,25HSE@186801|Clostridia,36KTH@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1887351_5	1321778.HMPREF1982_02894	6.646e-166	533.0	COG1409@1|root,COG1409@2|Bacteria,1UQCQ@1239|Firmicutes,248P1@186801|Clostridia	186801|Clostridia	M	Ser Thr phosphatase family protein	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
HKD2_k127_1887351_6	293826.Amet_3602	1.124e-133	435.0	COG0673@1|root,COG0673@2|Bacteria,1TR8S@1239|Firmicutes,25AZV@186801|Clostridia,36DGC@31979|Clostridiaceae	186801|Clostridia	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	1.1.1.371	ko:K16044	ko00562,ko01120,map00562,map01120	-	R09954	RC00182	ko00000,ko00001,ko01000	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
HKD2_k127_1887351_0	398512.JQKC01000001_gene2398	0.0	1140.0	28I0T@1|root,2Z85H@2|Bacteria,1TQRJ@1239|Firmicutes,247Z4@186801|Clostridia	186801|Clostridia	S	Domain of unknown function (DUF4914)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4914
HKD2_k127_1887351_2	768710.DesyoDRAFT_3955	1.194e-253	791.0	COG0665@1|root,COG0723@1|root,COG0665@2|Bacteria,COG0723@2|Bacteria,1TR1R@1239|Firmicutes,24A67@186801|Clostridia,261F0@186807|Peptococcaceae	186801|Clostridia	CE	Glycine D-amino acid oxidase (deaminating)	-	-	-	-	-	-	-	-	-	-	-	-	DAO,Rieske
HKD2_k127_1887351_12	1305836.AXVE01000012_gene160	1.512e-66	239.0	COG2206@1|root,COG2206@2|Bacteria,1TQIM@1239|Firmicutes,4HBV6@91061|Bacilli,26D2T@186818|Planococcaceae	91061|Bacilli	T	COG2206 HD-GYP domain	-	-	-	-	-	-	-	-	-	-	-	-	HD
HKD2_k127_1887351_7	293826.Amet_0518	1.611e-109	361.0	COG2177@1|root,COG2177@2|Bacteria,1V9I3@1239|Firmicutes,24GNH@186801|Clostridia,36QEB@31979|Clostridiaceae	186801|Clostridia	D	FtsX-like permease family	-	-	-	ko:K09811	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	-
HKD2_k127_1887351_9	293826.Amet_0519	2.341e-94	314.0	COG2884@1|root,COG2884@2|Bacteria,1VT39@1239|Firmicutes,24E18@186801|Clostridia,36RCI@31979|Clostridiaceae	186801|Clostridia	D	ATPases associated with a variety of cellular activities	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
HKD2_k127_1887351_8	293826.Amet_0520	1.632e-94	323.0	COG4942@1|root,COG4942@2|Bacteria,1VR95@1239|Firmicutes,24HB3@186801|Clostridia,36QKV@31979|Clostridiaceae	186801|Clostridia	D	peptidase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1887351_4	1120985.AUMI01000018_gene2943	2.756e-172	544.0	COG2376@1|root,COG2376@2|Bacteria,1TP92@1239|Firmicutes,4H3HH@909932|Negativicutes	909932|Negativicutes	G	DAK1 domain protein	dhaK	-	2.7.1.121	ko:K05878	ko00561,ko01100,map00561,map01100	-	R01012	RC00015,RC00017	ko00000,ko00001,ko01000	-	-	-	Dak1,Dak2
HKD2_k127_1887351_19	500635.MITSMUL_04292	8.901e-22	98.0	COG1925@1|root,COG1925@2|Bacteria,1VA0R@1239|Firmicutes,4H5F2@909932|Negativicutes	909932|Negativicutes	G	Phosphocarrier protein hpr	ptsH	-	-	ko:K11189	-	-	-	-	ko00000,ko02000	4.A.2.1	-	-	PTS-HPr
HKD2_k127_1887351_16	484770.UFO1_0520	7.329e-41	154.0	COG3412@1|root,COG3412@2|Bacteria,1VF32@1239|Firmicutes,4H562@909932|Negativicutes	909932|Negativicutes	S	dihydroxyacetone kinase, phosphotransfer subunit	-	-	2.7.1.121	ko:K05881	ko00561,map00561	-	R01012	RC00015,RC00017	ko00000,ko00001,ko01000,ko02000	-	-	-	EIIA-man
HKD2_k127_1887351_10	498761.HM1_0839	1.791e-75	260.0	COG1461@1|root,COG1461@2|Bacteria,1V4FH@1239|Firmicutes,24FUX@186801|Clostridia	186801|Clostridia	S	Dihydroxyacetone kinase, L subunit	dhaL	-	2.7.1.121	ko:K05879	ko00561,ko01100,map00561,map01100	-	R01012	RC00015,RC00017	ko00000,ko00001,ko01000	-	-	-	Dak2
HKD2_k127_1887351_17	1461580.CCAS010000032_gene2879	2.706e-29	126.0	COG1512@1|root,COG1512@2|Bacteria,1V5YF@1239|Firmicutes,4HK7U@91061|Bacilli,1ZDH4@1386|Bacillus	91061|Bacilli	S	TPM domain	-	-	-	ko:K06872	-	-	-	-	ko00000	-	-	-	TPM_phosphatase
HKD2_k127_1887351_15	318464.IO99_13010	3.924e-49	181.0	COG1704@1|root,COG1704@2|Bacteria,1V3Z0@1239|Firmicutes,24IH4@186801|Clostridia,36E1V@31979|Clostridiaceae	186801|Clostridia	S	LemA family	lemA	-	-	ko:K03744	-	-	-	-	ko00000	-	-	-	LemA
HKD2_k127_1887351_18	994573.T472_0200200	6.171e-28	117.0	COG3976@1|root,COG3976@2|Bacteria,1VFG0@1239|Firmicutes,24RHT@186801|Clostridia,36MVQ@31979|Clostridiaceae	186801|Clostridia	S	PFAM FMN-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	FMN_bind
HKD2_k127_1887351_14	666686.B1NLA3E_11880	7.272e-54	193.0	COG0716@1|root,COG0716@2|Bacteria,1VFBM@1239|Firmicutes,4HYKX@91061|Bacilli	91061|Bacilli	C	FMN binding	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1893822_1	755731.Clo1100_3706	2.661e-55	209.0	COG2244@1|root,COG2244@2|Bacteria,1TNYX@1239|Firmicutes,2485G@186801|Clostridia,36DMJ@31979|Clostridiaceae	186801|Clostridia	S	Stage V sporulation protein B	spoVB	-	-	ko:K06409	-	-	-	-	ko00000,ko02000	2.A.66.2.14	-	-	Polysacc_synt,Polysacc_synt_C
HKD2_k127_1893822_2	1304284.L21TH_0122	9.81e-33	141.0	COG3307@1|root,COG3307@2|Bacteria,1TQGY@1239|Firmicutes,24AB7@186801|Clostridia,36ERI@31979|Clostridiaceae	186801|Clostridia	M	O-Antigen ligase	-	-	-	ko:K18814	-	-	-	-	ko00000,ko02000	9.B.67.1	-	-	Wzy_C
HKD2_k127_1893822_0	273068.TTE0611	2.395e-122	417.0	COG4166@1|root,COG4166@2|Bacteria,1TNYQ@1239|Firmicutes,25E4B@186801|Clostridia,42FVD@68295|Thermoanaerobacterales	186801|Clostridia	E	Extracellular solute-binding protein, family 5	oppA	-	-	ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	SBP_bac_5
HKD2_k127_190080_5	268407.PWYN_20760	3.723e-77	259.0	COG0789@1|root,COG0789@2|Bacteria,1V3QI@1239|Firmicutes,4HH53@91061|Bacilli,26YH0@186822|Paenibacillaceae	91061|Bacilli	K	MerR family transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	MerR_1
HKD2_k127_190080_2	1262449.CP6013_3885	6.921e-105	342.0	COG0110@1|root,COG0110@2|Bacteria,1TSQQ@1239|Firmicutes,24B8G@186801|Clostridia,36HMK@31979|Clostridiaceae	186801|Clostridia	S	Hexapeptide repeat of succinyl-transferase	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep,Hexapep_2
HKD2_k127_190080_6	1123009.AUID01000031_gene1253	1.762e-36	145.0	COG4925@1|root,COG4925@2|Bacteria,1VA88@1239|Firmicutes,24N85@186801|Clostridia,26BZW@186813|unclassified Clostridiales	186801|Clostridia	P	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS	-	-	-	-	-	-	-	-	-	-	-	-	Cyclophil_like
HKD2_k127_190080_4	871968.DESME_04865	1.353e-78	264.0	COG1917@1|root,COG1917@2|Bacteria,1TRVH@1239|Firmicutes,249JY@186801|Clostridia,265MR@186807|Peptococcaceae	186801|Clostridia	S	conserved protein, contains double-stranded beta-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HKD2_k127_190080_0	658086.HMPREF0994_05997	1.351e-119	390.0	COG2768@1|root,COG2768@2|Bacteria,1TQAW@1239|Firmicutes,247IS@186801|Clostridia,27MH4@186928|unclassified Lachnospiraceae	186801|Clostridia	C	Domain of unknown function (DUF362)	-	-	-	ko:K07138	-	-	-	-	ko00000	-	-	-	DUF362,Fer4
HKD2_k127_190080_8	1321778.HMPREF1982_00920	0.0003504	43.0	COG5001@1|root,COG5001@2|Bacteria,1TP8V@1239|Firmicutes,247PX@186801|Clostridia,269ZG@186813|unclassified Clostridiales	186801|Clostridia	T	Putative diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS,PAS_8,PAS_9
HKD2_k127_190080_7	994573.T472_0216785	4.437e-18	84.0	COG1979@1|root,COG1979@2|Bacteria,1TPS3@1239|Firmicutes,248DW@186801|Clostridia,36EU1@31979|Clostridiaceae	186801|Clostridia	C	Dehydrogenase	-	-	-	ko:K19955	-	-	-	-	ko00000,ko01000	-	-	-	Fe-ADH
HKD2_k127_190080_3	994573.T472_0216785	8.531e-85	284.0	COG1979@1|root,COG1979@2|Bacteria,1TPS3@1239|Firmicutes,248DW@186801|Clostridia,36EU1@31979|Clostridiaceae	186801|Clostridia	C	Dehydrogenase	-	-	-	ko:K19955	-	-	-	-	ko00000,ko01000	-	-	-	Fe-ADH
HKD2_k127_190080_1	699248.SRA_09718	5.185e-117	381.0	COG2828@1|root,COG2828@2|Bacteria,1TPP6@1239|Firmicutes,4HD7I@91061|Bacilli	91061|Bacilli	C	PrpF protein	yraM	-	-	-	-	-	-	-	-	-	-	-	PrpF
HKD2_k127_191344_1	1089548.KI783301_gene2923	1.36e-09	59.0	COG0444@1|root,COG0444@2|Bacteria,1TP6E@1239|Firmicutes,4HA4E@91061|Bacilli,3WEA2@539002|Bacillales incertae sedis	91061|Bacilli	P	Belongs to the ABC transporter superfamily	oppD2	-	-	ko:K15583	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
HKD2_k127_191344_0	1321778.HMPREF1982_04447	1.323e-165	525.0	COG4608@1|root,COG4608@2|Bacteria,1V36J@1239|Firmicutes,24C3R@186801|Clostridia,267P6@186813|unclassified Clostridiales	186801|Clostridia	E	ABC transporter, ATP-binding protein	oppF	-	-	ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
HKD2_k127_1946527_5	350688.Clos_2544	1.59e-133	429.0	COG1995@1|root,COG1995@2|Bacteria,1TQGT@1239|Firmicutes,24A12@186801|Clostridia,36E2Z@31979|Clostridiaceae	186801|Clostridia	C	Belongs to the PdxA family	pdxA	-	1.1.1.262,1.1.1.408,1.1.1.409	ko:K00097,ko:K22024	ko00750,ko01100,map00750,map01100	M00124	R05681,R05837,R07406	RC00089,RC00675,RC01475	ko00000,ko00001,ko00002,ko01000	-	-	-	PdxA
HKD2_k127_1946527_2	1123009.AUID01000017_gene356	5.974e-172	550.0	COG3395@1|root,COG3395@2|Bacteria,1TPNP@1239|Firmicutes,24AJF@186801|Clostridia,26AGZ@186813|unclassified Clostridiales	186801|Clostridia	S	Putative nucleotide-binding of sugar-metabolising enzyme	-	-	2.7.1.219,2.7.1.220	ko:K22129	-	-	-	-	ko00000,ko01000	-	-	-	DUF1357_C,DUF1537
HKD2_k127_1946527_8	350688.Clos_2546	1.066e-81	279.0	COG1349@1|root,COG1349@2|Bacteria,1TSF8@1239|Firmicutes,2498W@186801|Clostridia,36FN5@31979|Clostridiaceae	186801|Clostridia	K	Transcriptional regulator DeoR family	-	-	-	-	-	-	-	-	-	-	-	-	DeoRC,HTH_DeoR
HKD2_k127_1946527_9	1294142.CINTURNW_4493	1.286e-21	95.0	COG1251@1|root,COG1251@2|Bacteria,1VKDD@1239|Firmicutes,24QQH@186801|Clostridia,36MPI@31979|Clostridiaceae	186801|Clostridia	C	2Fe-2S -binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer2_BFD
HKD2_k127_1946527_6	1294142.CINTURNW_1538	7.103e-132	445.0	COG0642@1|root,COG2205@2|Bacteria,1TQMV@1239|Firmicutes,247SE@186801|Clostridia,36ERX@31979|Clostridiaceae	186801|Clostridia	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_9
HKD2_k127_1946527_1	332101.JIBU02000012_gene893	1.542e-188	596.0	COG0527@1|root,COG0527@2|Bacteria,1TPQJ@1239|Firmicutes,24811@186801|Clostridia,36EUA@31979|Clostridiaceae	186801|Clostridia	E	Belongs to the aspartokinase family	lysC	-	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT,ACT_7
HKD2_k127_1946527_0	332101.JIBU02000012_gene892	4.78e-199	627.0	COG0019@1|root,COG0019@2|Bacteria,1TPE9@1239|Firmicutes,247X7@186801|Clostridia,36FIT@31979|Clostridiaceae	186801|Clostridia	E	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine	lysA	-	4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
HKD2_k127_1946527_7	1294142.CINTURNW_1328	4.889e-97	320.0	COG1584@1|root,COG1584@2|Bacteria,1TSYX@1239|Firmicutes,249E0@186801|Clostridia,36FRN@31979|Clostridiaceae	186801|Clostridia	S	GPR1/FUN34/yaaH family	yaaH	-	-	ko:K07034	-	-	-	-	ko00000	-	-	-	Grp1_Fun34_YaaH
HKD2_k127_1946527_3	1410653.JHVC01000019_gene2151	1.013e-159	513.0	COG0513@1|root,COG0513@2|Bacteria,1TQ9R@1239|Firmicutes,249Z4@186801|Clostridia,36DKG@31979|Clostridiaceae	186801|Clostridia	L	DEAD DEAH box helicase	-	-	-	-	-	-	-	-	-	-	-	-	DEAD,Helicase_C
HKD2_k127_1946527_4	1195236.CTER_3314	2.02e-146	467.0	COG0550@1|root,COG0551@1|root,COG0550@2|Bacteria,COG0551@2|Bacteria,1TPJD@1239|Firmicutes,24810@186801|Clostridia,3WGKN@541000|Ruminococcaceae	186801|Clostridia	L	DNA topoisomerase III	topB	-	5.99.1.2	ko:K03169	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	Topoisom_bac,Toprim
HKD2_k127_1953871_3	1321778.HMPREF1982_02034	3.214e-75	255.0	COG1399@1|root,COG1399@2|Bacteria,1VEXU@1239|Firmicutes,24RKT@186801|Clostridia,269YN@186813|unclassified Clostridiales	186801|Clostridia	S	Uncharacterized ACR, COG1399	-	-	-	ko:K07040	-	-	-	-	ko00000	-	-	-	DUF177
HKD2_k127_1953871_0	1321778.HMPREF1982_02033	3.53e-220	687.0	COG0282@1|root,COG0282@2|Bacteria,1TQ22@1239|Firmicutes,248ZM@186801|Clostridia,267UV@186813|unclassified Clostridiales	186801|Clostridia	C	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction	ackA	GO:0006082,GO:0006083,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016053,GO:0016999,GO:0017000,GO:0017144,GO:0019413,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:0072330,GO:1901576	2.7.2.1	ko:K00925	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00315,R01353	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetate_kinase
HKD2_k127_1953871_1	1321778.HMPREF1982_02032	1.303e-184	581.0	COG0280@1|root,COG0280@2|Bacteria,1TPQ0@1239|Firmicutes,247W9@186801|Clostridia,2681I@186813|unclassified Clostridiales	186801|Clostridia	C	Phosphate acetyl/butaryl transferase	pta	GO:0006082,GO:0006083,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016053,GO:0016999,GO:0017000,GO:0017144,GO:0019413,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:0072330,GO:1901576	2.3.1.8	ko:K00625	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00230,R00921	RC00004,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000	-	-	-	PTA_PTB
HKD2_k127_1953871_2	1321778.HMPREF1982_02031	4.66e-121	397.0	COG1323@1|root,COG1323@2|Bacteria,1TPP2@1239|Firmicutes,247UP@186801|Clostridia,2690A@186813|unclassified Clostridiales	186801|Clostridia	S	HIGH Nucleotidyl Transferase	-	-	-	-	-	-	-	-	-	-	-	-	HIGH_NTase1
HKD2_k127_1969654_1	290402.Cbei_4805	3.684e-95	315.0	COG1486@1|root,COG1486@2|Bacteria,1TQ9I@1239|Firmicutes,24995@186801|Clostridia,36E8R@31979|Clostridiaceae	186801|Clostridia	G	Family 4 glycosyl hydrolase C-terminal domain	-	-	3.2.1.122,3.2.1.86	ko:K01222,ko:K01232	ko00010,ko00500,map00010,map00500	-	R00837,R00838,R00839,R05133,R05134,R06113	RC00049,RC00171,RC00714	ko00000,ko00001,ko01000	-	GH4,GT4	-	Glyco_hydro_4,Glyco_hydro_4C
HKD2_k127_1969654_0	1196322.A370_03690	5.423e-239	748.0	COG1263@1|root,COG1264@1|root,COG1263@2|Bacteria,COG1264@2|Bacteria,1TPJ8@1239|Firmicutes,24809@186801|Clostridia,36DV0@31979|Clostridiaceae	186801|Clostridia	G	PTS system, glucose-like IIB	-	-	2.7.1.199,2.7.1.208	ko:K02790,ko:K02791	ko00010,ko00500,ko00520,ko02060,map00010,map00500,map00520,map02060	M00266	R02738,R04111	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.1.1.3	-	-	PTS_EIIB,PTS_EIIC
HKD2_k127_1972629_3	203119.Cthe_2588	6.479e-24	101.0	COG1521@1|root,COG1521@2|Bacteria,1TR0X@1239|Firmicutes,248PX@186801|Clostridia,3WHZV@541000|Ruminococcaceae	186801|Clostridia	H	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis	coaX	-	2.7.1.33	ko:K03525	ko00770,ko01100,map00770,map01100	M00120	R02971,R03018,R04391	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Pan_kinase
HKD2_k127_1972629_0	1304880.JAGB01000003_gene991	8.924e-132	427.0	COG0042@1|root,COG0042@2|Bacteria,1TQ2R@1239|Firmicutes,248HD@186801|Clostridia	186801|Clostridia	J	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines	dus	-	-	ko:K05540	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Dus
HKD2_k127_1972629_2	351627.Csac_0823	1.913e-51	187.0	2AVM5@1|root,31MDW@2|Bacteria,1V7D6@1239|Firmicutes,24JAJ@186801|Clostridia,42G0V@68295|Thermoanaerobacterales	186801|Clostridia	S	PFAM helix-turn-helix domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
HKD2_k127_1972629_1	580331.Thit_2043	7.474e-109	360.0	COG5322@1|root,COG5322@2|Bacteria,1TQ2E@1239|Firmicutes,24A1Y@186801|Clostridia,42EUN@68295|Thermoanaerobacterales	186801|Clostridia	S	oxidoreductase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_20115_5	1120998.AUFC01000005_gene630	1.219e-150	482.0	COG0549@1|root,COG0549@2|Bacteria,1TP9H@1239|Firmicutes,2482W@186801|Clostridia,3WCY8@538999|Clostridiales incertae sedis	186801|Clostridia	E	Amino acid kinase family	-	-	2.7.2.2	ko:K00926	ko00220,ko00230,ko00910,ko01100,ko01120,ko01200,map00220,map00230,map00910,map01100,map01120,map01200	-	R00150,R01395	RC00002,RC00043,RC02803,RC02804	ko00000,ko00001,ko01000	-	-	-	AA_kinase
HKD2_k127_20115_1	1286171.EAL2_c08070	4.196e-178	567.0	COG2233@1|root,COG2233@2|Bacteria,1TQKX@1239|Firmicutes,2485Z@186801|Clostridia,25VSJ@186806|Eubacteriaceae	186801|Clostridia	F	Psort location CytoplasmicMembrane, score 10.00	pyrP	-	-	ko:K02824	-	-	-	-	ko00000,ko02000	2.A.40.1.1,2.A.40.1.2	-	-	Xan_ur_permease
HKD2_k127_20115_0	941824.TCEL_00901	2.691e-186	590.0	COG1301@1|root,COG1301@2|Bacteria,1TPME@1239|Firmicutes,247UX@186801|Clostridia,36DYZ@31979|Clostridiaceae	186801|Clostridia	C	Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family	-	-	-	-	-	-	-	-	-	-	-	-	SDF
HKD2_k127_20115_10	1408422.JHYF01000006_gene1239	4.717e-99	342.0	COG1388@1|root,COG1388@2|Bacteria,1TSVC@1239|Firmicutes,248VQ@186801|Clostridia,36EW2@31979|Clostridiaceae	186801|Clostridia	M	LysM domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF3794,LysM
HKD2_k127_20115_11	471875.RUMLAC_00331	8.149e-85	291.0	COG1947@1|root,COG1947@2|Bacteria,1TPXV@1239|Firmicutes,24898@186801|Clostridia,3WH6J@541000|Ruminococcaceae	186801|Clostridia	I	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol	ispE	-	2.7.1.148	ko:K00919	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05634	RC00002,RC01439	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
HKD2_k127_20115_14	485916.Dtox_0202	1.653e-68	239.0	COG1802@1|root,COG1802@2|Bacteria,1TSV2@1239|Firmicutes,24C0U@186801|Clostridia,260IE@186807|Peptococcaceae	186801|Clostridia	K	PFAM Bacterial regulatory proteins, gntR family	ydfH_4	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
HKD2_k127_20115_13	697281.Mahau_2081	2.81e-72	252.0	COG0746@1|root,COG0746@2|Bacteria,1V4AK@1239|Firmicutes,249SR@186801|Clostridia,42EKJ@68295|Thermoanaerobacterales	186801|Clostridia	H	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_3
HKD2_k127_20115_3	1094508.Tsac_0752	1.418e-172	556.0	COG0697@1|root,COG0697@2|Bacteria,1TP7K@1239|Firmicutes,248Q8@186801|Clostridia,42EYQ@68295|Thermoanaerobacterales	186801|Clostridia	EG	GerA spore germination protein	gerA	-	-	ko:K06310	-	-	-	-	ko00000	-	-	-	GerA
HKD2_k127_20115_15	340099.Teth39_0181	2.22e-61	226.0	COG0531@1|root,COG0531@2|Bacteria,1TZQ6@1239|Firmicutes,24EQ1@186801|Clostridia,42G6B@68295|Thermoanaerobacterales	186801|Clostridia	E	PFAM spore germination	-	-	-	ko:K06296,ko:K06311	-	-	-	-	ko00000,ko02000	2.A.3.9.3,2.A.3.9.4	-	-	Spore_permease
HKD2_k127_20115_17	1121289.JHVL01000001_gene1901	1.417e-50	194.0	28IEM@1|root,2Z8GN@2|Bacteria,1UB3Y@1239|Firmicutes,247YH@186801|Clostridia,36DZ5@31979|Clostridiaceae	186801|Clostridia	S	Spore germination B3/ GerAC like, C-terminal	-	-	-	ko:K06297	-	-	-	-	ko00000	-	-	-	Spore_GerAC
HKD2_k127_20115_16	1195236.CTER_1954	2.378e-59	213.0	2AUKD@1|root,31K93@2|Bacteria,1V6PK@1239|Firmicutes,24J91@186801|Clostridia,3WJSP@541000|Ruminococcaceae	186801|Clostridia	S	stage II sporulation protein R	spoIIR	-	-	ko:K06387	-	-	-	-	ko00000	-	-	-	Spore_II_R
HKD2_k127_20115_12	720554.Clocl_0598	2.596e-77	265.0	COG3409@1|root,COG3773@1|root,COG3409@2|Bacteria,COG3773@2|Bacteria,1TRFW@1239|Firmicutes,24912@186801|Clostridia,3WHI9@541000|Ruminococcaceae	186801|Clostridia	M	spore cortex-lytic enzyme	sleB	-	3.5.1.28	ko:K01449	-	-	R04112	RC00064,RC00141	ko00000,ko01000	-	-	-	Hydrolase_2,PG_binding_1
HKD2_k127_20115_9	509191.AEDB02000035_gene2149	4.346e-99	339.0	COG2959@1|root,COG2959@2|Bacteria,1TT9K@1239|Firmicutes,24893@186801|Clostridia,3WH09@541000|Ruminococcaceae	186801|Clostridia	H	germination protein YpeB	ypeB	-	-	ko:K06313	-	-	-	-	ko00000	-	-	-	PepSY,YPEB
HKD2_k127_20115_20	509191.AEDB02000055_gene3717	7.523e-19	87.0	2E2ZT@1|root,32Y0E@2|Bacteria,1VEHE@1239|Firmicutes,24R2Z@186801|Clostridia,3WMQG@541000|Ruminococcaceae	186801|Clostridia	S	Small, acid-soluble spore proteins, alpha/beta type	-	-	-	ko:K06423	-	-	-	-	ko00000	-	-	-	SASP
HKD2_k127_20115_18	1321778.HMPREF1982_00210	2.608e-24	104.0	COG1359@1|root,COG1359@2|Bacteria,1VJ7Y@1239|Firmicutes,24RJ7@186801|Clostridia,26C6I@186813|unclassified Clostridiales	186801|Clostridia	S	Antibiotic biosynthesis monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	ABM
HKD2_k127_20115_6	1304880.JAGB01000002_gene2382	2.353e-131	428.0	COG1181@1|root,COG1181@2|Bacteria,1TP2Y@1239|Firmicutes,248CR@186801|Clostridia	186801|Clostridia	F	Belongs to the D-alanine--D-alanine ligase family	ddl	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C,Dala_Dala_lig_N
HKD2_k127_20115_7	350688.Clos_1960	2.775e-130	422.0	COG0784@1|root,COG0835@1|root,COG0784@2|Bacteria,COG0835@2|Bacteria,1TRJU@1239|Firmicutes,24AQW@186801|Clostridia,36GIH@31979|Clostridiaceae	186801|Clostridia	T	Chemotaxis protein CheV	cheV	-	2.7.13.3	ko:K03407,ko:K03415	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	CheW,Response_reg
HKD2_k127_20115_8	857293.CAAU_0877	2.145e-103	342.0	COG0796@1|root,COG0796@2|Bacteria,1TPPR@1239|Firmicutes,249MB@186801|Clostridia,36DHC@31979|Clostridiaceae	186801|Clostridia	M	Provides the (R)-glutamate required for cell wall biosynthesis	murI	-	5.1.1.3	ko:K01776	ko00471,ko01100,map00471,map01100	-	R00260	RC00302	ko00000,ko00001,ko01000,ko01011	-	-	-	Asp_Glu_race
HKD2_k127_20115_19	1304284.L21TH_0220	9.165e-23	103.0	COG4506@1|root,COG4506@2|Bacteria,1V8CS@1239|Firmicutes,24JQR@186801|Clostridia,36M2V@31979|Clostridiaceae	186801|Clostridia	S	Domain of unknown function (DUF1934)	ywiB	-	-	-	-	-	-	-	-	-	-	-	DUF1934
HKD2_k127_20115_4	1304284.L21TH_0217	8.545e-170	545.0	COG3829@1|root,COG3829@2|Bacteria,1TP0E@1239|Firmicutes,247MB@186801|Clostridia,36EY7@31979|Clostridiaceae	186801|Clostridia	KT	Bacterial regulatory protein, Fis family	-	-	-	ko:K06714	-	-	-	-	ko00000,ko03000	-	-	-	HTH_8,PAS,PAS_4,PAS_9,Sigma54_activat
HKD2_k127_20115_2	1122973.KB904240_gene638	6.77e-173	550.0	COG0604@1|root,COG0604@2|Bacteria,4NE6Y@976|Bacteroidetes,2FRBA@200643|Bacteroidia,22XG0@171551|Porphyromonadaceae	976|Bacteroidetes	C	Dehydrogenase	-	-	1.4.1.11	ko:K18012	ko00310,map00310	-	R03349	RC00888	ko00000,ko00001,ko01000	-	-	-	ADH_zinc_N
HKD2_k127_2015966_1	755731.Clo1100_0934	3.569e-75	256.0	COG2972@1|root,COG2972@2|Bacteria,1UXY6@1239|Firmicutes,24CN6@186801|Clostridia,36FUW@31979|Clostridiaceae	186801|Clostridia	T	Histidine kinase	-	-	2.7.13.3	ko:K07718	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,His_kinase
HKD2_k127_2015966_0	1195236.CTER_1793	1.854e-162	516.0	COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1UYH7@1239|Firmicutes,249E3@186801|Clostridia	186801|Clostridia	T	response regulator	-	-	-	ko:K07720	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_18,Response_reg
HKD2_k127_2023091_3	1121423.JONT01000006_gene2492	1.455e-09	62.0	COG0226@1|root,COG0226@2|Bacteria,1VT8I@1239|Firmicutes,24IAW@186801|Clostridia,2653C@186807|Peptococcaceae	186801|Clostridia	P	PBP superfamily domain	-	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
HKD2_k127_2023091_2	1286171.EAL2_c07930	6.753e-60	212.0	COG1704@1|root,COG1704@2|Bacteria,1V3Z0@1239|Firmicutes,24IH4@186801|Clostridia,25W6Q@186806|Eubacteriaceae	186801|Clostridia	S	LemA family	-	-	-	ko:K03744	-	-	-	-	ko00000	-	-	-	LemA
HKD2_k127_2023091_1	1286171.EAL2_c07920	6.019e-95	334.0	COG4907@1|root,COG4907@2|Bacteria,1TS3Q@1239|Firmicutes,25CFE@186801|Clostridia	186801|Clostridia	S	Predicted membrane protein (DUF2207)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2207
HKD2_k127_2023091_0	1304284.L21TH_0535	1.77e-116	382.0	COG3457@1|root,COG3457@2|Bacteria,1TNYJ@1239|Firmicutes,248MC@186801|Clostridia,36ESB@31979|Clostridiaceae	186801|Clostridia	E	Alanine racemase, N-terminal domain	-	-	5.1.1.12	ko:K21898	ko00472,map00472	-	R00672	RC00302	ko00000,ko00001,ko01000	-	-	-	Ala_racemase_N
HKD2_k127_203610_0	1304880.JAGB01000003_gene1306	1.003e-166	531.0	COG0215@1|root,COG0215@2|Bacteria,1TP9D@1239|Firmicutes,247KS@186801|Clostridia	186801|Clostridia	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	-	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e,tRNA-synt_1g
HKD2_k127_203610_1	913865.DOT_2538	3.024e-147	478.0	COG1322@1|root,COG1322@2|Bacteria,1TPWI@1239|Firmicutes,24CA4@186801|Clostridia,26006@186807|Peptococcaceae	186801|Clostridia	S	PFAM RmuC family	rmuC	-	-	ko:K09760	-	-	-	-	ko00000	-	-	-	RmuC
HKD2_k127_203610_5	720554.Clocl_3979	2.786e-42	160.0	COG1939@1|root,COG1939@2|Bacteria,1VA5V@1239|Firmicutes,24MR1@186801|Clostridia,3WJN8@541000|Ruminococcaceae	186801|Clostridia	J	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)	mrnC	-	-	ko:K11145	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Ribonuclease_3
HKD2_k127_203610_2	1304284.L21TH_1889	1.268e-115	377.0	COG1351@1|root,COG1351@2|Bacteria,1TRAA@1239|Firmicutes,249DJ@186801|Clostridia,36G0P@31979|Clostridiaceae	186801|Clostridia	H	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant	thyX	-	2.1.1.148	ko:K03465	ko00240,ko00670,ko01100,map00240,map00670,map01100	-	R06613	RC00022,RC00332	ko00000,ko00001,ko01000	-	-	-	Thy1
HKD2_k127_203610_4	272563.CD630_00550	1.632e-99	336.0	COG0566@1|root,COG0566@2|Bacteria,1TP9G@1239|Firmicutes,247SC@186801|Clostridia,25QG5@186804|Peptostreptococcaceae	186801|Clostridia	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family	yacO	-	2.1.1.185	ko:K03218	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SpoU_methylase,SpoU_sub_bind
HKD2_k127_203610_3	1121472.AQWN01000015_gene1356	1.302e-101	336.0	COG1595@1|root,COG1595@2|Bacteria,1TP55@1239|Firmicutes,249VX@186801|Clostridia,260BB@186807|Peptococcaceae	186801|Clostridia	K	RNA polymerase sigma factor, sigma-70 family	sigH	-	-	ko:K03091	-	-	-	-	ko00000,ko03021	-	-	-	GerE,Sigma70_r2,Sigma70_r4_2
HKD2_k127_203610_6	1321778.HMPREF1982_04618	3.45e-32	125.0	COG0050@1|root,COG0050@2|Bacteria,1TPKC@1239|Firmicutes,2485I@186801|Clostridia,267PG@186813|unclassified Clostridiales	186801|Clostridia	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
HKD2_k127_2051474_4	1231057.AMGD01000015_gene411	2.39e-09	62.0	COG0823@1|root,COG1388@1|root,COG4219@1|root,COG0823@2|Bacteria,COG1388@2|Bacteria,COG4219@2|Bacteria,1UYWD@1239|Firmicutes,4HD21@91061|Bacilli,26GHS@186818|Planococcaceae	91061|Bacilli	KMTU	WD40-like Beta Propeller Repeat	-	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	LysM,PD40
HKD2_k127_2051474_5	1121344.JHZO01000003_gene974	8.405e-06	57.0	2BZ6P@1|root,2Z8AB@2|Bacteria,1TRT3@1239|Firmicutes,247PA@186801|Clostridia,3WH7B@541000|Ruminococcaceae	186801|Clostridia	S	Domain of unknown function (DUF2935)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2935
HKD2_k127_2051474_2	1230342.CTM_10933	1.262e-39	158.0	COG1051@1|root,COG1051@2|Bacteria,1UV6B@1239|Firmicutes,24WQE@186801|Clostridia,36PW0@31979|Clostridiaceae	186801|Clostridia	F	Nudix hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
HKD2_k127_2051474_0	1031288.AXAA01000057_gene747	2.975e-117	383.0	COG1284@1|root,COG1284@2|Bacteria,1TR9J@1239|Firmicutes,24BGW@186801|Clostridia,36DT5@31979|Clostridiaceae	186801|Clostridia	S	Uncharacterised 5xTM membrane BCR, YitT family COG1284	-	-	-	-	-	-	-	-	-	-	-	-	DUF2179,YitT_membrane
HKD2_k127_2051474_1	1540257.JQMW01000013_gene1036	1.639e-64	227.0	COG1404@1|root,COG1404@2|Bacteria,1V3SC@1239|Firmicutes,24IBK@186801|Clostridia,36IS9@31979|Clostridiaceae	186801|Clostridia	O	Domain of unknown function (DUF4397)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4397
HKD2_k127_2051474_3	1408422.JHYF01000015_gene352	6.829e-20	100.0	COG3173@1|root,COG3173@2|Bacteria,1UZ6J@1239|Firmicutes	1239|Firmicutes	S	Phosphotransferase enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	APH
HKD2_k127_211424_9	931276.Cspa_c28700	1.858e-11	68.0	COG2217@1|root,COG2217@2|Bacteria,1TQ07@1239|Firmicutes,248EH@186801|Clostridia,36DXT@31979|Clostridiaceae	186801|Clostridia	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	cadA	-	3.6.3.3,3.6.3.5	ko:K01534	-	-	-	-	ko00000,ko01000	3.A.3.6	-	-	E1-E2_ATPase,HMA,Hydrolase
HKD2_k127_211424_3	1304880.JAGB01000003_gene1115	7.145e-58	203.0	COG0640@1|root,COG0640@2|Bacteria,1VA6G@1239|Firmicutes,24JCN@186801|Clostridia	186801|Clostridia	K	transcriptional regulator	-	-	-	ko:K21903	-	-	-	-	ko00000,ko03000	-	-	-	HTH_5
HKD2_k127_211424_5	431943.CKL_0335	5.538e-38	145.0	COG1993@1|root,COG1993@2|Bacteria,1VB0Q@1239|Firmicutes,24N0G@186801|Clostridia,36KFV@31979|Clostridiaceae	186801|Clostridia	S	Uncharacterized ACR, COG1993	-	-	-	ko:K09137	-	-	-	-	ko00000	-	-	-	DUF190
HKD2_k127_211424_4	1321778.HMPREF1982_02301	4.069e-41	154.0	COG0239@1|root,COG0239@2|Bacteria,1VEH7@1239|Firmicutes,24QSV@186801|Clostridia	186801|Clostridia	D	Important for reducing fluoride concentration in the cell, thus reducing its toxicity	crcB	-	-	ko:K06199	-	-	-	-	ko00000,ko02000	1.A.43.1,1.A.43.2,1.A.43.3	-	-	CRCB
HKD2_k127_211424_6	431943.CKL_0333	1.123e-37	146.0	COG0239@1|root,COG0239@2|Bacteria,1VEH7@1239|Firmicutes,24QSV@186801|Clostridia,36KYS@31979|Clostridiaceae	186801|Clostridia	D	Important for reducing fluoride concentration in the cell, thus reducing its toxicity	crcB	-	-	ko:K06199	-	-	-	-	ko00000,ko02000	1.A.43.1,1.A.43.2,1.A.43.3	-	-	CRCB
HKD2_k127_211424_0	509191.AEDB02000064_gene503	1.148e-259	809.0	COG0595@1|root,COG0595@2|Bacteria,1TQ9G@1239|Firmicutes,2488J@186801|Clostridia,3WH9M@541000|Ruminococcaceae	186801|Clostridia	S	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay	rnj	-	-	ko:K12574	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	Lactamase_B,Lactamase_B_2,RMMBL
HKD2_k127_211424_8	398511.BpOF4_18145	1.656e-22	98.0	COG3311@1|root,COG3311@2|Bacteria,1VEEK@1239|Firmicutes	1239|Firmicutes	K	TIGRFAM DNA binding domain, excisionase family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_17
HKD2_k127_211424_7	1391647.AVSV01000029_gene1896	5.802e-32	128.0	COG5658@1|root,COG5658@2|Bacteria,1VB6E@1239|Firmicutes,24MSY@186801|Clostridia,36N68@31979|Clostridiaceae	186801|Clostridia	S	SdpI/YhfL protein family	-	-	-	-	-	-	-	-	-	-	-	-	SdpI
HKD2_k127_211424_10	580327.Tthe_0521	0.0006441	47.0	2BB9B@1|root,324S0@2|Bacteria,1UQYK@1239|Firmicutes,24VAB@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_211424_1	1122947.FR7_2663	1.636e-96	324.0	COG0697@1|root,COG0697@2|Bacteria,1UH2I@1239|Firmicutes,4H63J@909932|Negativicutes	909932|Negativicutes	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HKD2_k127_211424_2	768706.Desor_1092	9.01e-95	313.0	COG0122@1|root,COG0122@2|Bacteria,1V2ZM@1239|Firmicutes,248KP@186801|Clostridia,263U5@186807|Peptococcaceae	186801|Clostridia	L	endonuclease III	-	-	2.1.1.63,3.2.2.21	ko:K00567,ko:K01247	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
HKD2_k127_219011_0	748727.CLJU_c37360	2.046e-218	693.0	COG1026@1|root,COG1026@2|Bacteria,1TPD1@1239|Firmicutes,258W0@186801|Clostridia,36DD6@31979|Clostridiaceae	186801|Clostridia	S	Peptidase M16	-	-	-	ko:K06972	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M16C_assoc,Peptidase_M16,Peptidase_M16_C,SLH
HKD2_k127_219011_5	555079.Toce_0386	1.252e-89	302.0	COG1606@1|root,COG1606@2|Bacteria,1TPB2@1239|Firmicutes,2485J@186801|Clostridia,42FCT@68295|Thermoanaerobacterales	186801|Clostridia	S	PFAM PP-loop domain protein	-	-	-	ko:K06864	-	-	-	-	ko00000	-	-	-	ATP_bind_3,NAD_synthase,QueC
HKD2_k127_219011_4	398512.JQKC01000030_gene4396	8.501e-90	302.0	COG1691@1|root,COG1691@2|Bacteria,1TP0Z@1239|Firmicutes,24815@186801|Clostridia,3WHWU@541000|Ruminococcaceae	186801|Clostridia	S	AIR carboxylase	-	-	-	ko:K06898	-	-	-	-	ko00000	-	-	-	AIRC
HKD2_k127_219011_2	1487921.DP68_10765	6.886e-123	402.0	COG0310@1|root,COG0310@2|Bacteria,1TPEN@1239|Firmicutes,248S9@186801|Clostridia,36EPJ@31979|Clostridiaceae	186801|Clostridia	P	Cobalamin (Vitamin B12) biosynthesis CbiM protein	cbiM2	-	-	ko:K02007	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	CbiM,PDGLE
HKD2_k127_219011_6	868595.Desca_1922	9.04e-82	280.0	COG0619@1|root,COG0619@2|Bacteria,1U6XW@1239|Firmicutes,24EV0@186801|Clostridia,26197@186807|Peptococcaceae	186801|Clostridia	P	Cobalt ABC transporter, permease protein CbiQ	cbiQ	-	-	ko:K02008	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	CbiQ
HKD2_k127_219011_3	868595.Desca_1921	4.207e-113	370.0	COG1122@1|root,COG1122@2|Bacteria,1TSSM@1239|Firmicutes,249KS@186801|Clostridia,2602Q@186807|Peptococcaceae	186801|Clostridia	P	ABC-type cobalt transport system ATPase component	cbiO	-	-	ko:K02006	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	ABC_tran
HKD2_k127_219011_1	1499689.CCNN01000014_gene3172	2.442e-152	486.0	COG0281@1|root,COG0281@2|Bacteria,1TPJ3@1239|Firmicutes,2487U@186801|Clostridia,36DTC@31979|Clostridiaceae	186801|Clostridia	C	malic enzyme	-	-	1.1.1.38	ko:K00027	ko00620,ko01200,ko02020,map00620,map01200,map02020	-	R00214	RC00105	ko00000,ko00001,ko01000	-	-	-	Malic_M,malic
HKD2_k127_2198161_0	398512.JQKC01000008_gene964	5.411e-254	794.0	COG0173@1|root,COG0173@2|Bacteria,1TPCN@1239|Firmicutes,247Z3@186801|Clostridia,3WGX1@541000|Ruminococcaceae	186801|Clostridia	J	Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp)	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
HKD2_k127_2198161_1	1408422.JHYF01000001_gene2721	2.731e-99	330.0	COG1179@1|root,COG1179@2|Bacteria,1TQ7A@1239|Firmicutes,248RA@186801|Clostridia,36F3J@31979|Clostridiaceae	186801|Clostridia	H	PFAM UBA THIF-type NAD FAD binding protein	-	-	-	ko:K22132	-	-	-	-	ko00000,ko03016	-	-	-	ThiF
HKD2_k127_2198161_5	1347392.CCEZ01000043_gene555	1.024e-20	94.0	COG1937@1|root,COG1937@2|Bacteria,1VEF5@1239|Firmicutes,24QRR@186801|Clostridia,36MMZ@31979|Clostridiaceae	186801|Clostridia	S	Metal-sensitive transcriptional repressor	csoR	-	-	ko:K21600	-	-	-	-	ko00000,ko03000	-	-	-	Trns_repr_metal
HKD2_k127_2198161_4	1292035.H476_0486	1.042e-26	114.0	COG3086@1|root,COG3086@2|Bacteria,1VEYP@1239|Firmicutes,24R8Z@186801|Clostridia,25RMJ@186804|Peptostreptococcaceae	186801|Clostridia	T	Positive regulator of sigma(E), RseC/MucC	-	-	-	ko:K03803	-	-	-	-	ko00000,ko03021	-	-	-	RseC_MucC
HKD2_k127_2198161_2	697281.Mahau_0938	1.419e-39	149.0	COG3118@1|root,COG3118@2|Bacteria,1VA3Y@1239|Firmicutes,24MM5@186801|Clostridia,42GS3@68295|Thermoanaerobacterales	186801|Clostridia	O	Belongs to the thioredoxin family	trxA	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
HKD2_k127_2198161_3	293826.Amet_2366	3.725e-27	113.0	COG3829@1|root,COG3829@2|Bacteria,1TP0E@1239|Firmicutes,247MB@186801|Clostridia,36EY7@31979|Clostridiaceae	186801|Clostridia	KT	Bacterial regulatory protein, Fis family	-	-	-	ko:K06714	-	-	-	-	ko00000,ko03000	-	-	-	HTH_8,PAS,PAS_4,PAS_9,Sigma54_activat
HKD2_k127_2287910_3	350688.Clos_2544	6.565e-52	184.0	COG1995@1|root,COG1995@2|Bacteria,1TQGT@1239|Firmicutes,24A12@186801|Clostridia,36E2Z@31979|Clostridiaceae	186801|Clostridia	C	Belongs to the PdxA family	pdxA	-	1.1.1.262,1.1.1.408,1.1.1.409	ko:K00097,ko:K22024	ko00750,ko01100,map00750,map01100	M00124	R05681,R05837,R07406	RC00089,RC00675,RC01475	ko00000,ko00001,ko00002,ko01000	-	-	-	PdxA
HKD2_k127_2287910_0	350688.Clos_2543	7.478e-209	657.0	COG2610@1|root,COG2610@2|Bacteria,1TQ14@1239|Firmicutes,248PQ@186801|Clostridia,36ESW@31979|Clostridiaceae	186801|Clostridia	EG	Gluconate	gntP	-	-	ko:K03299	-	-	-	-	ko00000,ko02000	2.A.8	-	-	GntP_permease
HKD2_k127_2287910_2	1321778.HMPREF1982_01563	7.298e-127	411.0	COG0508@1|root,COG0508@2|Bacteria,1V9QA@1239|Firmicutes,24KV2@186801|Clostridia	186801|Clostridia	C	dehydrogenase complex catalyzes the overall conversion of	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2287910_1	1321778.HMPREF1982_04502	5.442e-208	651.0	COG0031@1|root,COG0031@2|Bacteria,1TZEW@1239|Firmicutes,249RW@186801|Clostridia,267P0@186813|unclassified Clostridiales	186801|Clostridia	E	Pyridoxal-phosphate dependent enzyme	-	-	-	-	-	-	-	-	-	-	-	-	PALP
HKD2_k127_233476_3	748727.CLJU_c18080	3.194e-07	55.0	COG0845@1|root,COG0845@2|Bacteria,1V158@1239|Firmicutes,24D97@186801|Clostridia,36W0Y@31979|Clostridiaceae	186801|Clostridia	M	HlyD family secretion protein	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
HKD2_k127_233476_0	1408422.JHYF01000009_gene2144	5.242e-124	405.0	COG0444@1|root,COG0444@2|Bacteria,1TP6E@1239|Firmicutes,247NN@186801|Clostridia,36FRW@31979|Clostridiaceae	186801|Clostridia	EP	Oligopeptide/dipeptide transporter, C-terminal region	-	-	-	ko:K02031,ko:K15583	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
HKD2_k127_233476_1	1347392.CCEZ01000016_gene2929	2.145e-88	320.0	COG1173@1|root,COG1173@2|Bacteria,1V21B@1239|Firmicutes,2498X@186801|Clostridia,36GUS@31979|Clostridiaceae	186801|Clostridia	EP	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,Peptidase_M28
HKD2_k127_233476_2	1347392.CCEZ01000016_gene2928	1.076e-42	165.0	COG0601@1|root,COG0601@2|Bacteria,1VB92@1239|Firmicutes,24A7D@186801|Clostridia,36HT5@31979|Clostridiaceae	186801|Clostridia	EP	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
HKD2_k127_2347043_1	1123009.AUID01000018_gene299	5.751e-113	368.0	COG0187@1|root,COG0187@2|Bacteria,1TQ0R@1239|Firmicutes,248AV@186801|Clostridia,2682S@186813|unclassified Clostridiales	186801|Clostridia	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
HKD2_k127_2347043_0	1304284.L21TH_2557	0.0	1097.0	COG0188@1|root,COG0188@2|Bacteria,1TP2Z@1239|Firmicutes,2482G@186801|Clostridia,36E5Z@31979|Clostridiaceae	186801|Clostridia	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
HKD2_k127_2347043_2	1304284.L21TH_1095	3.566e-52	198.0	COG2206@1|root,COG2206@2|Bacteria,1TQIM@1239|Firmicutes,248S5@186801|Clostridia,36FJB@31979|Clostridiaceae	186801|Clostridia	T	SMART Metal-dependent phosphohydrolase, HD region	-	-	-	-	-	-	-	-	-	-	-	-	HD,HD_5
HKD2_k127_2374354_0	1321778.HMPREF1982_01840	1.07e-77	263.0	28H5M@1|root,2Z7I7@2|Bacteria,1UC9R@1239|Firmicutes,248GH@186801|Clostridia,26AYZ@186813|unclassified Clostridiales	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2374354_1	272562.CA_C1083	3.347e-25	113.0	COG1988@1|root,COG1988@2|Bacteria,1V742@1239|Firmicutes,24KF4@186801|Clostridia,36N1T@31979|Clostridiaceae	186801|Clostridia	S	LexA-binding, inner membrane-associated putative hydrolase	-	-	-	ko:K07038	-	-	-	-	ko00000	-	-	-	YdjM
HKD2_k127_2430277_0	1476973.JMMB01000007_gene628	3.97e-176	574.0	COG0210@1|root,COG0210@2|Bacteria,1TPVG@1239|Firmicutes,2484I@186801|Clostridia,25QTG@186804|Peptostreptococcaceae	186801|Clostridia	L	DNA helicase	yjcD	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
HKD2_k127_2430277_1	1408422.JHYF01000006_gene1188	7.996e-20	94.0	COG0243@1|root,COG0243@2|Bacteria,1TPZG@1239|Firmicutes,247JV@186801|Clostridia,36E8E@31979|Clostridiaceae	186801|Clostridia	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
HKD2_k127_2481962_6	293826.Amet_4410	9.837e-52	187.0	2AXEX@1|root,31PEA@2|Bacteria,1V8IU@1239|Firmicutes,24KMI@186801|Clostridia,36RYT@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2481962_4	935948.KE386494_gene393	1.595e-60	219.0	COG0697@1|root,COG0697@2|Bacteria,1UHT1@1239|Firmicutes,24AQZ@186801|Clostridia,42EW0@68295|Thermoanaerobacterales	186801|Clostridia	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HKD2_k127_2481962_0	720554.Clocl_4000	1.155e-158	519.0	COG2262@1|root,COG2262@2|Bacteria,1TNZB@1239|Firmicutes,248IU@186801|Clostridia,3WH00@541000|Ruminococcaceae	186801|Clostridia	S	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis	hflX	-	-	ko:K03665	-	-	-	-	ko00000,ko03009	-	-	-	GTP-bdg_M,GTP-bdg_N,MMR_HSR1
HKD2_k127_2481962_16	596329.HMPREF0631_1517	0.0003186	52.0	COG0697@1|root,COG0697@2|Bacteria,1V6A5@1239|Firmicutes,25CFH@186801|Clostridia,25T7C@186804|Peptostreptococcaceae	186801|Clostridia	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HKD2_k127_2481962_10	1211817.CCAT010000070_gene1257	3.552e-37	143.0	COG1832@1|root,COG1832@2|Bacteria,1V7C7@1239|Firmicutes,24P0N@186801|Clostridia,36UCP@31979|Clostridiaceae	186801|Clostridia	S	CoA-binding domain protein	-	-	-	ko:K06929	-	-	-	-	ko00000	-	-	-	CoA_binding_2
HKD2_k127_2481962_11	2325.TKV_c11220	5.771e-36	140.0	COG0730@1|root,COG0730@2|Bacteria,1VAFU@1239|Firmicutes,24MTI@186801|Clostridia,42GU8@68295|Thermoanaerobacterales	186801|Clostridia	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
HKD2_k127_2481962_8	2325.TKV_c11230	1.81e-41	155.0	COG0730@1|root,COG0730@2|Bacteria,1VAMI@1239|Firmicutes,24MXA@186801|Clostridia,42GYA@68295|Thermoanaerobacterales	186801|Clostridia	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
HKD2_k127_2481962_3	857293.CAAU_2123	2.451e-87	295.0	COG0171@1|root,COG0171@2|Bacteria,1TQ38@1239|Firmicutes,2484Z@186801|Clostridia	186801|Clostridia	H	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses	nadE	-	6.3.1.5	ko:K01916	ko00760,ko01100,map00760,map01100	M00115	R00189	RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	NAD_synthase
HKD2_k127_2481962_2	941824.TCEL_00390	1.467e-92	311.0	COG0217@1|root,COG0217@2|Bacteria,1TPP5@1239|Firmicutes,247NK@186801|Clostridia,36E08@31979|Clostridiaceae	186801|Clostridia	K	transcriptional regulatory protein	yebC	-	-	-	-	-	-	-	-	-	-	-	Transcrip_reg
HKD2_k127_2481962_13	526224.Bmur_0904	1.402e-17	93.0	COG3206@1|root,COG3206@2|Bacteria,2JBI8@203691|Spirochaetes	203691|Spirochaetes	M	Domain of unknown function (DUF4349)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4349
HKD2_k127_2481962_1	1121335.Clst_1662	1.52e-107	370.0	COG3858@1|root,COG3858@2|Bacteria,1U6TM@1239|Firmicutes,24B95@186801|Clostridia	186801|Clostridia	L	Glycosyl hydrolases family 18	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_18,SLH
HKD2_k127_2481962_7	293826.Amet_2514	6.948e-47	175.0	COG5018@1|root,COG5018@2|Bacteria,1VAUM@1239|Firmicutes,25DMJ@186801|Clostridia,36FCY@31979|Clostridiaceae	186801|Clostridia	L	Exonuclease, RNase T and DNA polymerase III	-	-	-	-	-	-	-	-	-	-	-	-	RNase_T
HKD2_k127_2481962_15	1291050.JAGE01000001_gene130	5.213e-14	74.0	2EH2E@1|root,33AUC@2|Bacteria,1VMDA@1239|Firmicutes,24WKH@186801|Clostridia	186801|Clostridia	S	Uracil-DNA glycosylase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2481962_12	1121289.JHVL01000004_gene2063	4.2e-19	96.0	2C6GU@1|root,32RHA@2|Bacteria,1V93R@1239|Firmicutes,24KD5@186801|Clostridia,36M1G@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	BofC_C
HKD2_k127_2481962_5	1195236.CTER_4599	1.666e-57	203.0	COG0817@1|root,COG0817@2|Bacteria,1V3N9@1239|Firmicutes,24HMI@186801|Clostridia,3WIS5@541000|Ruminococcaceae	186801|Clostridia	L	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group	ruvC	-	3.1.22.4	ko:K01159	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvC
HKD2_k127_2572764_0	293826.Amet_0488	1.658e-150	492.0	COG4585@1|root,COG4585@2|Bacteria,1TQI3@1239|Firmicutes,249R9@186801|Clostridia,36FHU@31979|Clostridiaceae	186801|Clostridia	T	Histidine kinase	-	-	2.7.13.3	ko:K11623	ko02020,map02020	M00484	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA_3
HKD2_k127_2572764_1	1321778.HMPREF1982_02638	2.202e-70	243.0	COG2197@1|root,COG2197@2|Bacteria,1V367@1239|Firmicutes,24HW8@186801|Clostridia	186801|Clostridia	K	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HKD2_k127_2610410_5	1121289.JHVL01000055_gene526	2.999e-97	322.0	COG1788@1|root,COG1788@2|Bacteria,1V21Q@1239|Firmicutes,25E61@186801|Clostridia,36UK0@31979|Clostridiaceae	186801|Clostridia	I	TIGRFAM 3-oxoacid CoA-transferase, A subunit	-	-	2.8.3.8,2.8.3.9	ko:K01034	ko00310,ko00627,ko00640,ko00650,ko01100,ko01120,ko02020,map00310,map00627,map00640,map00650,map01100,map01120,map02020	-	R01179,R01359,R01365,R07832	RC00012,RC00014	ko00000,ko00001,ko01000	-	-	-	CoA_trans
HKD2_k127_2610410_3	1304284.L21TH_2531	3.036e-99	327.0	COG2057@1|root,COG2057@2|Bacteria,1TNY5@1239|Firmicutes,247ZM@186801|Clostridia,36GAR@31979|Clostridiaceae	186801|Clostridia	I	3-oxoacid CoA-transferase, B subunit	ctfB2	-	2.8.3.8,2.8.3.9	ko:K01035	ko00310,ko00627,ko00640,ko00650,ko01100,ko01120,ko02020,map00310,map00627,map00640,map00650,map01100,map01120,map02020	-	R01179,R01359,R01365,R07832	RC00012,RC00014	ko00000,ko00001,ko01000	-	-	-	CoA_trans
HKD2_k127_2610410_13	2325.TKV_c01590	8.909e-29	126.0	29RDG@1|root,30CFT@2|Bacteria,1V604@1239|Firmicutes,24J2B@186801|Clostridia,42GGQ@68295|Thermoanaerobacterales	186801|Clostridia	S	TATA-box binding	-	-	-	-	-	-	-	-	-	-	-	-	DUF1779
HKD2_k127_2610410_1	1304284.L21TH_2518	2.601e-172	550.0	COG0766@1|root,COG0766@2|Bacteria,1TPAU@1239|Firmicutes,2488W@186801|Clostridia,36DC0@31979|Clostridiaceae	186801|Clostridia	M	Belongs to the EPSP synthase family. MurA subfamily	murA	-	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase
HKD2_k127_2610410_7	2325.TKV_c01680	5.101e-85	292.0	COG2385@1|root,COG2385@2|Bacteria,1TQSI@1239|Firmicutes,249H0@186801|Clostridia,42FIQ@68295|Thermoanaerobacterales	186801|Clostridia	D	TIGRFAM stage II sporulation protein D	spoIID	-	-	ko:K06381	-	-	-	-	ko00000	-	-	-	SpoIID
HKD2_k127_2610410_11	1408422.JHYF01000024_gene3844	3.164e-42	164.0	COG0739@1|root,COG0739@2|Bacteria,1V96D@1239|Firmicutes,24AXE@186801|Clostridia,36FA4@31979|Clostridiaceae	186801|Clostridia	M	peptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
HKD2_k127_2610410_12	865861.AZSU01000002_gene2949	6.494e-35	134.0	COG1609@1|root,COG1609@2|Bacteria,1VADF@1239|Firmicutes,24MXI@186801|Clostridia,36KQT@31979|Clostridiaceae	186801|Clostridia	K	Stage III sporulation protein D	spoIIID	-	-	ko:K06283	-	-	-	-	ko00000,ko03000	-	-	-	SpoIIID
HKD2_k127_2610410_2	1195236.CTER_4027	7.34e-160	509.0	COG1077@1|root,COG1077@2|Bacteria,1TP51@1239|Firmicutes,247RG@186801|Clostridia,3WMWJ@541000|Ruminococcaceae	186801|Clostridia	D	MreB/Mbl protein	mreB	-	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
HKD2_k127_2610410_8	635013.TherJR_2882	1.033e-68	241.0	COG4786@1|root,COG4786@2|Bacteria,1TRFQ@1239|Firmicutes,24C2V@186801|Clostridia,261UD@186807|Peptococcaceae	186801|Clostridia	N	basal body rod protein	flgG	-	-	ko:K02392	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod,Flg_bbr_C
HKD2_k127_2610410_6	350688.Clos_2549	9.404e-92	308.0	COG4786@1|root,COG4786@2|Bacteria,1TT5Z@1239|Firmicutes,248M9@186801|Clostridia,36EXN@31979|Clostridiaceae	186801|Clostridia	N	flagellar basal body	flgG	-	-	ko:K02390,ko:K02392	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod,Flg_bbr_C
HKD2_k127_2610410_15	1195236.CTER_4024	7.111e-16	81.0	COG3951@1|root,COG3951@2|Bacteria,1VFX2@1239|Firmicutes,24RKJ@186801|Clostridia	186801|Clostridia	N	PFAM Flagellar protein FlgJ-like	flgJ	-	-	ko:K02395	-	-	-	-	ko00000,ko02035	-	-	-	Rod-binding
HKD2_k127_2610410_9	1304284.L21TH_1230	8.622e-68	232.0	COG0764@1|root,COG0764@2|Bacteria,1V6EX@1239|Firmicutes,24JAW@186801|Clostridia,36IPJ@31979|Clostridiaceae	186801|Clostridia	I	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs	fabZ	-	4.2.1.59	ko:K02372	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07764,R10117,R10121	RC00831,RC01095	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FabA
HKD2_k127_2610410_10	545243.BAEV01000003_gene3414	2.212e-50	184.0	2ADZG@1|root,305V6@2|Bacteria,1V4RZ@1239|Firmicutes,25DJH@186801|Clostridia,36UC7@31979|Clostridiaceae	186801|Clostridia	S	sporulation protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF1256
HKD2_k127_2610410_14	509191.AEDB02000028_gene2901	2.27e-24	104.0	2EFGV@1|root,3399G@2|Bacteria,1U5Y2@1239|Firmicutes,24WP5@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2610410_0	697303.Thewi_0557	4.691e-206	646.0	COG0192@1|root,COG0192@2|Bacteria,1TPCV@1239|Firmicutes,248QF@186801|Clostridia,42ESY@68295|Thermoanaerobacterales	186801|Clostridia	H	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme	metK	-	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
HKD2_k127_2610410_4	1304284.L21TH_2580	6.8e-99	330.0	COG0507@1|root,COG0507@2|Bacteria,1TPZH@1239|Firmicutes,247R7@186801|Clostridia,36ER3@31979|Clostridiaceae	186801|Clostridia	L	DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity	recD2	-	3.1.11.5	ko:K03581	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AAA_30,HHH_4,HHH_5,UvrD_C_2
HKD2_k127_2626987_0	1499689.CCNN01000007_gene2269	0.0	1467.0	COG0458@1|root,COG0458@2|Bacteria,1TPID@1239|Firmicutes,2498I@186801|Clostridia,36DIP@31979|Clostridiaceae	186801|Clostridia	F	Carbamoyl-phosphate synthetase ammonia chain	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
HKD2_k127_2626987_4	649747.HMPREF0083_03214	7.305e-44	170.0	COG0726@1|root,COG0726@2|Bacteria,1V827@1239|Firmicutes,4HGM9@91061|Bacilli,26UHB@186822|Paenibacillaceae	91061|Bacilli	G	Polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
HKD2_k127_2626987_2	1291050.JAGE01000001_gene853	2.07e-176	581.0	COG0664@1|root,COG0664@2|Bacteria,1TSX5@1239|Firmicutes,24A8U@186801|Clostridia	186801|Clostridia	T	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
HKD2_k127_2626987_3	1209989.TepiRe1_0517	3.343e-95	320.0	COG0760@1|root,COG0760@2|Bacteria,1TX3R@1239|Firmicutes,24C7H@186801|Clostridia,42GQY@68295|Thermoanaerobacterales	186801|Clostridia	M	Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins	prsA	-	5.2.1.8	ko:K03769,ko:K07533	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_2,Rotamase_3,SurA_N_2,SurA_N_3
HKD2_k127_2626987_1	1230342.CTM_19694	5.246e-245	759.0	COG4868@1|root,COG4868@2|Bacteria,1TQYE@1239|Firmicutes,247YI@186801|Clostridia,36FKP@31979|Clostridiaceae	186801|Clostridia	S	Belongs to the UPF0371 family	-	-	-	-	-	-	-	-	-	-	-	-	DUF1846
HKD2_k127_2626987_5	1033737.CAEV01000023_gene3478	5.888e-35	134.0	COG4868@1|root,COG4868@2|Bacteria,1TQYE@1239|Firmicutes,247YI@186801|Clostridia,36FKP@31979|Clostridiaceae	186801|Clostridia	S	Belongs to the UPF0371 family	-	-	-	-	-	-	-	-	-	-	-	-	DUF1846
HKD2_k127_2635923_1	536227.CcarbDRAFT_3459	5.481e-61	216.0	COG0746@1|root,COG0746@2|Bacteria,1VA6T@1239|Firmicutes,24JG6@186801|Clostridia,36JB4@31979|Clostridiaceae	186801|Clostridia	H	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor	mobA	-	2.7.7.77	ko:K03752,ko:K13818	ko00790,ko01100,map00790,map01100	-	R11581	-	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
HKD2_k127_2635923_0	563192.HMPREF0179_02137	4.798e-188	606.0	COG0543@1|root,COG2204@1|root,COG0543@2|Bacteria,COG2204@2|Bacteria,1PFUQ@1224|Proteobacteria,42YE4@68525|delta/epsilon subdivisions,2WUPI@28221|Deltaproteobacteria,2MET1@213115|Desulfovibrionales	28221|Deltaproteobacteria	CHT	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	DHODB_Fe-S_bind,Fer4_22,NAD_binding_1
HKD2_k127_2635923_2	351160.RCIX2373	2.042e-11	64.0	COG0243@1|root,arCOG01491@2157|Archaea,2XT94@28890|Euryarchaeota,2NBP4@224756|Methanomicrobia	28890|Euryarchaeota	C	Molybdopterin oxidoreductase Fe4S4 domain	narB	-	1.17.1.9,1.20.2.1,1.20.9.1,1.7.7.2	ko:K00123,ko:K00367,ko:K00372,ko:K08356	ko00630,ko00680,ko00910,ko01100,ko01120,ko01200,map00630,map00680,map00910,map01100,map01120,map01200	M00531	R00519,R00791,R00798,R01106	RC02796,RC02812	ko00000,ko00001,ko00002,ko01000,ko02000	5.A.3.6	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
HKD2_k127_2639981_2	574087.Acear_2067	1.922e-81	279.0	COG1135@1|root,COG1135@2|Bacteria,1TPPN@1239|Firmicutes,248PZ@186801|Clostridia,3WA8U@53433|Halanaerobiales	186801|Clostridia	P	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system	metN	-	-	ko:K02071	ko02010,map02010	M00238	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.24	-	-	ABC_tran,NIL
HKD2_k127_2639981_3	796940.HMPREF9628_01726	2.164e-72	250.0	COG2011@1|root,COG2011@2|Bacteria,1TRSY@1239|Firmicutes,24AZ9@186801|Clostridia,25QKR@186804|Peptostreptococcaceae	186801|Clostridia	P	ABC transporter permease	metI	-	-	ko:K02072	ko02010,map02010	M00238	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.24	-	-	BPD_transp_1
HKD2_k127_2639981_1	1121324.CLIT_14c00630	4.368e-100	333.0	COG1464@1|root,COG1464@2|Bacteria,1TQAS@1239|Firmicutes,247WV@186801|Clostridia	186801|Clostridia	P	Belongs to the nlpA lipoprotein family	metQ	-	-	ko:K02073	ko02010,map02010	M00238	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.24	-	-	Lipoprotein_9
HKD2_k127_2639981_0	1345695.CLSA_c35330	2.091e-112	378.0	COG0840@1|root,COG0840@2|Bacteria,1TRIC@1239|Firmicutes,24BC0@186801|Clostridia,36HUP@31979|Clostridiaceae	186801|Clostridia	NT	Chemoreceptor zinc-binding domain	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CZB,MCPsignal
HKD2_k127_2639981_5	871968.DESME_06380	4.944e-07	52.0	28T44@1|root,2ZFD6@2|Bacteria,1W6MQ@1239|Firmicutes,256JI@186801|Clostridia,266G0@186807|Peptococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2639981_4	1209989.TepiRe1_0374	4.262e-45	166.0	COG0426@1|root,COG0426@2|Bacteria,1TQE9@1239|Firmicutes,249CU@186801|Clostridia,42FP2@68295|Thermoanaerobacterales	186801|Clostridia	C	flavodoxin nitric oxide synthase	norV	-	1.6.3.4	ko:K22405	-	-	-	-	ko00000,ko01000	-	-	-	Flavodoxin_1,Lactamase_B
HKD2_k127_26586_2	1347392.CCEZ01000011_gene2435	1.638e-41	158.0	COG0668@1|root,COG0668@2|Bacteria,1TR9Z@1239|Firmicutes,24CAG@186801|Clostridia,36EG8@31979|Clostridiaceae	186801|Clostridia	M	mechanosensitive ion channel	mscS	GO:0003674,GO:0005488,GO:0005515,GO:0042802	-	ko:K22044	-	-	-	-	ko00000,ko02000	1.A.23.3	-	-	MS_channel
HKD2_k127_26586_1	1408422.JHYF01000019_gene1415	2.15e-55	201.0	COG0425@1|root,COG0425@2|Bacteria,1V6BY@1239|Firmicutes,24JW8@186801|Clostridia,36IYS@31979|Clostridiaceae	186801|Clostridia	O	Belongs to the sulfur carrier protein TusA family	yedF	-	-	ko:K04085	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	DrsE,TusA
HKD2_k127_26586_3	350688.Clos_0021	1.315e-37	145.0	COG3877@1|root,COG3877@2|Bacteria,1VAFG@1239|Firmicutes,24MSP@186801|Clostridia,36JSB@31979|Clostridiaceae	186801|Clostridia	S	Protein of unknown function (DUF2089)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2089
HKD2_k127_26586_4	398512.JQKC01000002_gene1984	7.885e-37	154.0	COG3595@1|root,COG3595@2|Bacteria,1TU4Z@1239|Firmicutes,24C1X@186801|Clostridia,3WHND@541000|Ruminococcaceae	186801|Clostridia	S	Putative adhesin	-	-	-	-	-	-	-	-	-	-	-	-	DUF4097
HKD2_k127_26586_5	1304284.L21TH_1932	7.952e-21	100.0	2E196@1|root,32WPG@2|Bacteria,1VBTK@1239|Firmicutes,24QBM@186801|Clostridia,36MEX@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_26586_6	865861.AZSU01000002_gene2367	1.886e-12	75.0	COG1286@1|root,COG1286@2|Bacteria,1VH6E@1239|Firmicutes,24T69@186801|Clostridia,36NWS@31979|Clostridiaceae	186801|Clostridia	S	Colicin V production protein	-	-	-	ko:K03558	-	-	-	-	ko00000	-	-	-	Colicin_V
HKD2_k127_26586_7	865861.AZSU01000002_gene2366	1.013e-11	76.0	2BA2F@1|root,323G7@2|Bacteria,1UPZV@1239|Firmicutes,257M9@186801|Clostridia,36NJK@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_26586_0	1304284.L21TH_2183	7.908e-60	213.0	2ADZG@1|root,313RY@2|Bacteria,1V6JT@1239|Firmicutes,24JCA@186801|Clostridia,36HYA@31979|Clostridiaceae	186801|Clostridia	S	Sporulation protein YyaC	-	-	-	-	-	-	-	-	-	-	-	-	DUF1256
HKD2_k127_2690066_3	1195236.CTER_0262	1.982e-149	477.0	COG1879@1|root,COG1879@2|Bacteria,1UE0M@1239|Firmicutes,24C7Y@186801|Clostridia	186801|Clostridia	G	ABC-type sugar transport system, periplasmic	-	-	-	ko:K10439	ko02010,ko02030,map02010,map02030	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	Peripla_BP_4
HKD2_k127_2690066_0	1195236.CTER_0261	5.375e-228	715.0	COG1129@1|root,COG1129@2|Bacteria,1TP6I@1239|Firmicutes,247II@186801|Clostridia,3WH2F@541000|Ruminococcaceae	186801|Clostridia	G	ABC-type sugar transport system, ATPase component	-	-	3.6.3.17	ko:K10441	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	ABC_tran
HKD2_k127_2690066_2	1195236.CTER_0260	3.744e-150	481.0	COG1172@1|root,COG1172@2|Bacteria,1UYG4@1239|Firmicutes,24A8M@186801|Clostridia	186801|Clostridia	G	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K10440	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	BPD_transp_2
HKD2_k127_2690066_1	588581.Cpap_2799	2.141e-191	600.0	COG1082@1|root,COG1082@2|Bacteria,1TPJT@1239|Firmicutes,24DB5@186801|Clostridia	186801|Clostridia	G	AP endonuclease family 2 C terminus	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2,AP_endonuc_2_N
HKD2_k127_2690066_4	588581.Cpap_2798	2.368e-42	158.0	COG0673@1|root,COG0673@2|Bacteria,1TSWE@1239|Firmicutes,24CB6@186801|Clostridia,3WRKP@541000|Ruminococcaceae	186801|Clostridia	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
HKD2_k127_2743448_2	1487921.DP68_12985	8.523e-222	694.0	COG1906@1|root,COG1906@2|Bacteria,1UHZ1@1239|Firmicutes,248VI@186801|Clostridia,36UMH@31979|Clostridiaceae	186801|Clostridia	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2743448_1	1487921.DP68_12990	2.407e-237	737.0	COG1206@1|root,COG1206@2|Bacteria,1TRKH@1239|Firmicutes,249ZZ@186801|Clostridia,36HA1@31979|Clostridiaceae	186801|Clostridia	J	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GIDA
HKD2_k127_2743448_0	720554.Clocl_0905	6.31e-290	899.0	COG1231@1|root,COG1231@2|Bacteria,1TRJC@1239|Firmicutes,2484W@186801|Clostridia,3WN15@541000|Ruminococcaceae	186801|Clostridia	E	Flavin containing amine oxidoreductase	-	-	1.4.3.4	ko:K00274	ko00260,ko00330,ko00340,ko00350,ko00360,ko00380,ko00950,ko00982,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00260,map00330,map00340,map00350,map00360,map00380,map00950,map00982,map01100,map01110,map04726,map04728,map05030,map05031,map05034	M00135	R02173,R02382,R02529,R02532,R02613,R02908,R02919,R04025,R04300,R04674,R04890,R04893,R04894,R04907,R04908,R08346,R08347,R08348,R11354	RC00062,RC00160,RC00225,RC00676,RC00807,RC00808,RC01808,RC02226,RC02713	ko00000,ko00001,ko00002,ko01000	-	-	-	Amino_oxidase
HKD2_k127_2743448_4	1415775.U729_2999	1.231e-42	161.0	COG4430@1|root,COG4430@2|Bacteria,1VA6D@1239|Firmicutes,24N9F@186801|Clostridia,36K83@31979|Clostridiaceae	186801|Clostridia	S	Domain of unknown function (DUF1905)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1905,OmdA
HKD2_k127_2743448_3	1195236.CTER_1124	1.66e-108	358.0	2BCUG@1|root,326F1@2|Bacteria,1V8P9@1239|Firmicutes,24MGX@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2743448_6	931626.Awo_c15120	7.291e-17	82.0	COG0105@1|root,COG0105@2|Bacteria,1V44G@1239|Firmicutes,24JM5@186801|Clostridia,25Z8R@186806|Eubacteriaceae	186801|Clostridia	F	NDK	ndk	-	2.7.4.6	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	M00049,M00050,M00052,M00053	R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895	RC00002	ko00000,ko00001,ko00002,ko01000,ko04131	-	-	-	NDK
HKD2_k127_2743448_9	1499968.TCA2_4352	0.0003164	47.0	COG1352@1|root,COG2201@1|root,COG4191@1|root,COG1352@2|Bacteria,COG2201@2|Bacteria,COG4191@2|Bacteria,1TPD8@1239|Firmicutes,4HAS1@91061|Bacilli,26TPP@186822|Paenibacillaceae	91061|Bacilli	T	Methyltransferase, chemotaxis proteins	-	-	2.1.1.80,3.1.1.61	ko:K00575,ko:K13924	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest,CheR,CheR_N,HATPase_c,HisKA,PAS_10,PAS_3,PAS_9
HKD2_k127_2743448_8	1230342.CTM_18360	3.447e-15	76.0	COG0642@1|root,COG2205@2|Bacteria,1TQMV@1239|Firmicutes,247SE@186801|Clostridia,36ERF@31979|Clostridiaceae	186801|Clostridia	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg
HKD2_k127_2743448_5	118173.KB235914_gene3942	3.377e-28	120.0	COG1670@1|root,COG1670@2|Bacteria,1G5GV@1117|Cyanobacteria,1HAQ0@1150|Oscillatoriales	1117|Cyanobacteria	J	PFAM Acetyltransferase (GNAT) family	-	-	2.3.1.128	ko:K03790	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_3
HKD2_k127_2743448_7	2325.TKV_c02200	3.609e-16	79.0	COG1168@1|root,COG1168@2|Bacteria,1TP5G@1239|Firmicutes,248AY@186801|Clostridia,42F52@68295|Thermoanaerobacterales	186801|Clostridia	E	Aminotransferase class I and II	patB	-	4.4.1.8	ko:K14155	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	-	R00782,R01286,R02408,R04941	RC00056,RC00069,RC00382,RC00488,RC00710,RC01245,RC02303	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
HKD2_k127_2749051_4	1157490.EL26_17220	1.737e-50	187.0	COG2933@1|root,COG2933@2|Bacteria,1UZA9@1239|Firmicutes,4HDIN@91061|Bacilli	91061|Bacilli	J	Sam-dependent methyltransferase	ygdE	-	2.1.1.186	ko:K06968	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ
HKD2_k127_2749051_2	1304284.L21TH_2373	2.45e-138	452.0	COG0544@1|root,COG0544@2|Bacteria,1TQQ8@1239|Firmicutes,248C3@186801|Clostridia,36DYI@31979|Clostridiaceae	186801|Clostridia	D	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase	tig	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03545	-	-	-	-	ko00000	-	-	-	FKBP_C,Trigger_C,Trigger_N
HKD2_k127_2749051_3	941824.TCEL_00912	7.556e-103	337.0	COG0740@1|root,COG0740@2|Bacteria,1TQ91@1239|Firmicutes,247QY@186801|Clostridia,36ED5@31979|Clostridiaceae	186801|Clostridia	O	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins	clpP	-	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	CLP_protease
HKD2_k127_2749051_1	203119.Cthe_2741	4.67e-215	674.0	COG1219@1|root,COG1219@2|Bacteria,1TQ00@1239|Firmicutes,2481T@186801|Clostridia,3WGYG@541000|Ruminococcaceae	186801|Clostridia	O	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP	clpX	-	-	ko:K03544	ko04112,map04112	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA_2,ClpB_D2-small,zf-C4_ClpX
HKD2_k127_2749051_5	857293.CAAU_0446	9.824e-20	102.0	COG0457@1|root,COG1396@1|root,COG0457@2|Bacteria,COG1396@2|Bacteria,1VHJ0@1239|Firmicutes,247R0@186801|Clostridia,36EVF@31979|Clostridiaceae	186801|Clostridia	K	Helix-turn-helix domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_19,HTH_3,TPR_12,TPR_8
HKD2_k127_2749051_7	204669.Acid345_2141	4.338e-06	58.0	COG2133@1|root,COG2133@2|Bacteria,3Y98P@57723|Acidobacteria,2JP56@204432|Acidobacteriia	204432|Acidobacteriia	G	pyrroloquinoline quinone binding	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2749051_6	1469948.JPNB01000001_gene738	6.938e-07	56.0	COG1942@1|root,COG1942@2|Bacteria,1VHRB@1239|Firmicutes,24QWT@186801|Clostridia,36TAP@31979|Clostridiaceae	186801|Clostridia	S	Tautomerase enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Tautomerase_2
HKD2_k127_2749051_0	370438.PTH_0806	1.845e-217	685.0	COG1067@1|root,COG1474@1|root,COG1067@2|Bacteria,COG1474@2|Bacteria,1TP2K@1239|Firmicutes,247TX@186801|Clostridia,260E6@186807|Peptococcaceae	186801|Clostridia	LO	Belongs to the peptidase S16 family	lonB	-	3.4.21.53	ko:K01338,ko:K04076	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,Lon_C
HKD2_k127_2781511_0	1499689.CCNN01000007_gene2559	2.478e-269	844.0	COG0426@1|root,COG1251@1|root,COG0426@2|Bacteria,COG1251@2|Bacteria,1TQE9@1239|Firmicutes,249CU@186801|Clostridia,36E70@31979|Clostridiaceae	186801|Clostridia	C	flavodoxin nitric oxide synthase	fprA2	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0010181,GO:0016491,GO:0016651,GO:0016661,GO:0016662,GO:0016966,GO:0022900,GO:0032553,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0046872,GO:0046914,GO:0048037,GO:0050662,GO:0050664,GO:0055114,GO:0072593,GO:0097159,GO:0097367,GO:1901265,GO:1901363	1.6.3.4	ko:K22405	-	-	-	-	ko00000,ko01000	-	-	-	Flavodoxin_1,Lactamase_B,Pyr_redox_2
HKD2_k127_2781511_2	1260356.D920_00051	1.285e-66	241.0	COG0438@1|root,COG0438@2|Bacteria,1UZFG@1239|Firmicutes,4ISTK@91061|Bacilli,4B1X3@81852|Enterococcaceae	91061|Bacilli	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2781511_1	357809.Cphy_2888	8.287e-170	540.0	COG0562@1|root,COG0562@2|Bacteria,1TQB9@1239|Firmicutes,249BR@186801|Clostridia,21XYQ@1506553|Lachnoclostridium	186801|Clostridia	M	UDP-galactopyranose mutase	glf	-	5.4.99.9	ko:K01854	ko00052,ko00520,map00052,map00520	-	R00505,R09009	RC00317,RC02396	ko00000,ko00001,ko01000	-	-	-	GLF,NAD_binding_8
HKD2_k127_2787005_0	509191.AEDB02000063_gene452	5.517e-166	529.0	COG4962@1|root,COG4962@2|Bacteria,1TQ0Z@1239|Firmicutes,249VS@186801|Clostridia,3WN0W@541000|Ruminococcaceae	186801|Clostridia	U	Type II/IV secretion system protein	-	-	-	ko:K02283	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
HKD2_k127_2787005_1	398512.JQKC01000004_gene5119	5.15e-123	406.0	COG4753@1|root,COG4963@1|root,COG4753@2|Bacteria,COG4963@2|Bacteria,1UF2S@1239|Firmicutes,248CD@186801|Clostridia,3WKMS@541000|Ruminococcaceae	186801|Clostridia	D	4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family	-	-	-	ko:K02282	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	AAA_31,ParA,Response_reg
HKD2_k127_2787005_3	509191.AEDB02000063_gene454	1.205e-42	166.0	COG3745@1|root,COG3745@2|Bacteria,1V5FZ@1239|Firmicutes,24I7V@186801|Clostridia,3WPJ0@541000|Ruminococcaceae	186801|Clostridia	U	Chaperone for flagella basal body P-ring formation	-	-	-	ko:K02279	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	LysM,RcpC,SAF
HKD2_k127_2787005_2	401526.TcarDRAFT_1914	1.041e-65	236.0	COG4655@1|root,COG4655@2|Bacteria,1V25X@1239|Firmicutes,4H46N@909932|Negativicutes	909932|Negativicutes	S	Putative Flp pilus-assembly TadE/G-like	-	-	-	-	-	-	-	-	-	-	-	-	Tad
HKD2_k127_2787005_4	509191.AEDB02000063_gene456	4.222e-24	106.0	COG4961@1|root,COG4961@2|Bacteria,1VFNR@1239|Firmicutes,24R06@186801|Clostridia,3WPXA@541000|Ruminococcaceae	186801|Clostridia	U	TadE-like protein	-	-	-	-	-	-	-	-	-	-	-	-	TadE
HKD2_k127_2787005_5	857293.CAAU_2345	1.773e-06	51.0	COG3847@1|root,COG3847@2|Bacteria	2|Bacteria	U	Flp Fap pilin component	pilA	-	-	ko:K02651	ko04112,map04112	-	-	-	ko00000,ko00001,ko02035,ko02044	-	-	-	Class_IIIsignal,Flp_Fap
HKD2_k127_2820032_12	1511.CLOST_2587	2.675e-62	220.0	COG0706@1|root,COG0706@2|Bacteria,1TQ0J@1239|Firmicutes,247V9@186801|Clostridia,25RE0@186804|Peptostreptococcaceae	186801|Clostridia	U	60Kd inner membrane protein	oxaA	-	-	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03029	2.A.9	-	-	60KD_IMP
HKD2_k127_2820032_13	203119.Cthe_2366	6.069e-62	220.0	COG1847@1|root,COG1847@2|Bacteria,1V3IN@1239|Firmicutes,249EA@186801|Clostridia,3WHR4@541000|Ruminococcaceae	186801|Clostridia	S	R3H domain protein	jag	-	-	ko:K06346	-	-	-	-	ko00000	-	-	-	Jag_N,KH_4,R3H
HKD2_k127_2820032_2	350688.Clos_2872	1.27e-154	501.0	COG0486@1|root,COG0486@2|Bacteria,1TPJF@1239|Firmicutes,248A9@186801|Clostridia,36ECR@31979|Clostridiaceae	186801|Clostridia	J	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34	mnmE	-	-	ko:K03650	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko01000,ko03016	-	-	-	MMR_HSR1,MnmE_helical,TrmE_N
HKD2_k127_2820032_0	1031288.AXAA01000015_gene344	5.756e-270	843.0	COG0445@1|root,COG0445@2|Bacteria,1TQ4B@1239|Firmicutes,247U2@186801|Clostridia,36E85@31979|Clostridiaceae	186801|Clostridia	D	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34	gidA	-	-	ko:K03495	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko03016,ko03036	-	-	-	GIDA,GIDA_assoc
HKD2_k127_2820032_9	350688.Clos_2870	9.978e-83	283.0	COG0357@1|root,COG0357@2|Bacteria,1TPBT@1239|Firmicutes,247WM@186801|Clostridia,36EMZ@31979|Clostridiaceae	186801|Clostridia	J	Specifically methylates the N7 position of a guanine in 16S rRNA	rsmG	-	2.1.1.170	ko:K03501	-	-	-	-	ko00000,ko01000,ko03009,ko03036	-	-	-	GidB
HKD2_k127_2820032_7	1304284.L21TH_2542	8.039e-95	317.0	COG1475@1|root,COG1475@2|Bacteria,1TP0I@1239|Firmicutes,2488X@186801|Clostridia,36DCH@31979|Clostridiaceae	186801|Clostridia	K	Belongs to the ParB family	noc	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
HKD2_k127_2820032_15	1408422.JHYF01000006_gene1025	2.035e-29	119.0	COG2119@1|root,COG2119@2|Bacteria,1VI2Y@1239|Firmicutes,24RBN@186801|Clostridia,36S12@31979|Clostridiaceae	186801|Clostridia	S	Uncharacterized protein family UPF0016	-	-	-	-	-	-	-	-	-	-	-	-	UPF0016
HKD2_k127_2820032_4	1304284.L21TH_2541	1.649e-120	391.0	COG1192@1|root,COG1192@2|Bacteria,1TP8S@1239|Firmicutes,2488C@186801|Clostridia,36E15@31979|Clostridiaceae	186801|Clostridia	D	sporulation initiation inhibitor protein Soj	soj	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
HKD2_k127_2820032_8	858215.Thexy_2404	1.599e-93	314.0	COG1475@1|root,COG1475@2|Bacteria,1TQ2B@1239|Firmicutes,249VV@186801|Clostridia,42FPF@68295|Thermoanaerobacterales	186801|Clostridia	K	Belongs to the ParB family	spo0J	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
HKD2_k127_2820032_1	1128398.Curi_c28970	2.165e-155	499.0	COG0520@1|root,COG0520@2|Bacteria,1TQ1W@1239|Firmicutes,249CS@186801|Clostridia,267VY@186813|unclassified Clostridiales	186801|Clostridia	E	DegT/DnrJ/EryC1/StrS aminotransferase family	csd2	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
HKD2_k127_2820032_14	293826.Amet_4788	3.531e-34	138.0	COG1196@1|root,COG1196@2|Bacteria,1VAV4@1239|Firmicutes,24NPU@186801|Clostridia,36IVR@31979|Clostridiaceae	186801|Clostridia	D	Protein of unknown function (DUF4446)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4446
HKD2_k127_2820032_16	1304880.JAGB01000005_gene2452	5.254e-09	61.0	2DT5G@1|root,33ISX@2|Bacteria,1VPK2@1239|Firmicutes,24VA2@186801|Clostridia	186801|Clostridia	S	Uncharacterised protein family (UPF0180)	-	-	-	-	-	-	-	-	-	-	-	-	UPF0180
HKD2_k127_2820032_11	290402.Cbei_2435	3.129e-75	278.0	COG0642@1|root,COG2205@2|Bacteria,1TQMV@1239|Firmicutes,247SE@186801|Clostridia,36ERF@31979|Clostridiaceae	186801|Clostridia	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,MASE3,PAS,PAS_3,PAS_9
HKD2_k127_2820032_10	1410653.JHVC01000007_gene634	1.079e-77	268.0	COG0169@1|root,COG0169@2|Bacteria,1TQRY@1239|Firmicutes,2497S@186801|Clostridia,36E3G@31979|Clostridiaceae	186801|Clostridia	E	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)	aroE	-	1.1.1.25	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413	RC00206	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS14365	CM_2,SKI,Shikimate_DH,Shikimate_dh_N
HKD2_k127_2820032_5	568816.Acin_0028	5.184e-117	387.0	COG0082@1|root,COG0082@2|Bacteria,1TQ40@1239|Firmicutes,4H375@909932|Negativicutes	909932|Negativicutes	E	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system	aroC	-	4.2.3.5	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01714	RC00586	ko00000,ko00001,ko00002,ko01000	-	-	-	Chorismate_synt
HKD2_k127_2820032_3	1230342.CTM_15328	6.298e-146	473.0	COG0128@1|root,COG0128@2|Bacteria,1TPIH@1239|Firmicutes,2488G@186801|Clostridia,36E1H@31979|Clostridiaceae	186801|Clostridia	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	-	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	EPSP_synthase
HKD2_k127_2820032_6	86416.Clopa_4663	5.951e-114	377.0	COG0337@1|root,COG0337@2|Bacteria,1TPKZ@1239|Firmicutes,248H4@186801|Clostridia,36DGK@31979|Clostridiaceae	186801|Clostridia	E	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)	aroB	-	4.2.3.4	ko:K01735	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03083	RC00847	ko00000,ko00001,ko00002,ko01000	-	-	-	DHQ_synthase
HKD2_k127_2823202_9	935948.KE386495_gene2011	2.676e-49	191.0	COG4856@1|root,COG4856@2|Bacteria,1TSIV@1239|Firmicutes,24GKC@186801|Clostridia,42FQC@68295|Thermoanaerobacterales	186801|Clostridia	S	PFAM YbbR family protein	-	-	-	-	-	-	-	-	-	-	-	-	YbbR
HKD2_k127_2823202_1	857293.CAAU_0024	1.151e-197	629.0	COG2509@1|root,COG2509@2|Bacteria,1TPBW@1239|Firmicutes,247TR@186801|Clostridia,36DE1@31979|Clostridiaceae	186801|Clostridia	S	Oxidoreductase	-	-	-	ko:K07137	-	-	-	-	ko00000	-	-	-	HI0933_like,NAD_binding_8,Pyr_redox_2
HKD2_k127_2823202_0	1304284.L21TH_2285	9.761e-247	773.0	COG3829@1|root,COG3829@2|Bacteria,1TP0E@1239|Firmicutes,247MB@186801|Clostridia,36DY7@31979|Clostridiaceae	186801|Clostridia	KT	PFAM sigma-54 factor interaction domain-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,PAS,PAS_9,Sigma54_activat
HKD2_k127_2823202_4	857293.CAAU_0023	4.176e-159	509.0	COG3426@1|root,COG3426@2|Bacteria,1TPKE@1239|Firmicutes,24993@186801|Clostridia,36EWW@31979|Clostridiaceae	186801|Clostridia	C	Belongs to the acetokinase family	buk2	-	2.7.2.7	ko:K00929	ko00650,ko01100,map00650,map01100	-	R01688	RC00002,RC00043	ko00000,ko00001,ko01000	-	-	-	Acetate_kinase
HKD2_k127_2823202_6	293826.Amet_4309	1.334e-123	402.0	COG0280@1|root,COG0280@2|Bacteria,1TRQU@1239|Firmicutes,24857@186801|Clostridia,36DC6@31979|Clostridiaceae	186801|Clostridia	C	phosphate butyryltransferase	ptb	GO:0003674,GO:0003824,GO:0016740,GO:0016746,GO:0016747,GO:0050182	2.3.1.19	ko:K00634	ko00650,ko01100,map00650,map01100	-	R01174	RC00004,RC02816	ko00000,ko00001,ko01000	-	-	-	PTA_PTB
HKD2_k127_2823202_2	1304284.L21TH_2281	2.841e-180	569.0	COG3426@1|root,COG3426@2|Bacteria,1TPKE@1239|Firmicutes,24993@186801|Clostridia,36EGP@31979|Clostridiaceae	186801|Clostridia	C	Belongs to the acetokinase family	buk	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0044237,GO:0044424,GO:0044464,GO:0047761	2.7.2.7	ko:K00929	ko00650,ko01100,map00650,map01100	-	R01688	RC00002,RC00043	ko00000,ko00001,ko01000	-	-	-	Acetate_kinase
HKD2_k127_2823202_7	1304284.L21TH_0031	5.204e-81	275.0	COG0455@1|root,COG0455@2|Bacteria,1V1FH@1239|Firmicutes,24DP7@186801|Clostridia,36UV9@31979|Clostridiaceae	186801|Clostridia	D	bacterial-type flagellum organization	-	-	-	-	-	-	-	-	-	-	-	-	CbiA
HKD2_k127_2823202_10	1304284.L21TH_0030	2.642e-32	126.0	COG1143@1|root,COG1143@2|Bacteria,1UHZA@1239|Firmicutes,24QVY@186801|Clostridia,36UN5@31979|Clostridiaceae	186801|Clostridia	C	PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	1.2.7.3	ko:K00176	ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200	M00009,M00011,M00173,M00620	R01197	RC00004,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_4,Fer4_7
HKD2_k127_2823202_3	1304284.L21TH_0029	6.403e-165	524.0	COG0674@1|root,COG0674@2|Bacteria,1TSSC@1239|Firmicutes,248I6@186801|Clostridia,36EW0@31979|Clostridiaceae	186801|Clostridia	C	pyruvate flavodoxin ferredoxin oxidoreductase domain protein	vorB	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
HKD2_k127_2823202_5	1304284.L21TH_0028	5.754e-132	424.0	COG1013@1|root,COG1013@2|Bacteria,1UZ67@1239|Firmicutes,247Q7@186801|Clostridia,36DRF@31979|Clostridiaceae	186801|Clostridia	C	PFAM thiamine pyrophosphate protein domain protein TPP-binding	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
HKD2_k127_2823202_8	1121289.JHVL01000017_gene743	1.309e-73	251.0	COG1014@1|root,COG1014@2|Bacteria,1UYYG@1239|Firmicutes,24I53@186801|Clostridia,36G5Z@31979|Clostridiaceae	186801|Clostridia	C	PFAM pyruvate ferredoxin flavodoxin oxidoreductase	-	-	1.2.7.3	ko:K00177	ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200	M00009,M00011,M00173,M00620	R01197	RC00004,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR,Rubrerythrin
HKD2_k127_2828303_3	1443125.Z962_10790	1.541e-36	154.0	29Y5S@1|root,30JZ3@2|Bacteria,1V5JG@1239|Firmicutes,24BG8@186801|Clostridia,36FCG@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	ko:K02664	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	-
HKD2_k127_2828303_4	1347392.CCEZ01000043_gene275	7.128e-12	73.0	COG3166@1|root,COG3166@2|Bacteria,1VP6G@1239|Firmicutes	1239|Firmicutes	NU	Fimbrial assembly protein (PilN)	-	-	-	ko:K02663	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilN
HKD2_k127_2828303_1	1443125.Z962_10765	3.651e-61	224.0	COG4972@1|root,COG4972@2|Bacteria,1V3TN@1239|Firmicutes,24ASH@186801|Clostridia,36DVB@31979|Clostridiaceae	186801|Clostridia	NU	Type IV pilus assembly protein PilM	pilM	-	-	ko:K02662	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilM_2,PilN
HKD2_k127_2828303_0	1304284.L21TH_1832	5.783e-81	276.0	COG1989@1|root,COG1989@2|Bacteria,1TQY4@1239|Firmicutes,24HC0@186801|Clostridia,36H8M@31979|Clostridiaceae	186801|Clostridia	NOU	peptidase	hofD	-	3.4.23.43	ko:K02654	-	M00331	-	-	ko00000,ko00002,ko01000,ko01002,ko02035,ko02044	3.A.15.2	-	-	DiS_P_DiS,Peptidase_A24
HKD2_k127_2828303_2	1408306.JHXX01000003_gene1355	4.639e-50	188.0	COG5492@1|root,COG5492@2|Bacteria,1VBT6@1239|Firmicutes,25B2B@186801|Clostridia	186801|Clostridia	N	PFAM Bacterial Ig-like domain (group 2)	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,Flg_new
HKD2_k127_2834435_0	1304284.L21TH_1762	1.491e-22	112.0	COG4863@1|root,COG4863@2|Bacteria,1V68T@1239|Firmicutes,24HB0@186801|Clostridia,36JEP@31979|Clostridiaceae	186801|Clostridia	S	YycH protein	-	-	-	-	-	-	-	-	-	-	-	-	YycH
HKD2_k127_2834435_1	1121289.JHVL01000048_gene909	1.367e-12	74.0	COG4853@1|root,COG4853@2|Bacteria,1VF8C@1239|Firmicutes,24MBB@186801|Clostridia,36K4Q@31979|Clostridiaceae	186801|Clostridia	S	YycH protein	-	-	-	-	-	-	-	-	-	-	-	-	YycI
HKD2_k127_2841902_2	641107.CDLVIII_3989	5.275e-52	184.0	COG1670@1|root,COG1670@2|Bacteria,1V1G4@1239|Firmicutes,24G4Y@186801|Clostridia	186801|Clostridia	J	Acetyltransferase, gnat family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
HKD2_k127_2841902_4	573061.Clocel_2235	8.461e-13	70.0	COG0535@1|root,COG0535@2|Bacteria,1TR52@1239|Firmicutes,247SB@186801|Clostridia,36DWE@31979|Clostridiaceae	186801|Clostridia	C	Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Fer4_14,Radical_SAM
HKD2_k127_2841902_0	1321778.HMPREF1982_01895	3.547e-188	608.0	COG0840@1|root,COG0840@2|Bacteria,1TP5A@1239|Firmicutes,247S3@186801|Clostridia,26ARP@186813|unclassified Clostridiales	186801|Clostridia	NT	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer).	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	MCPsignal,dCache_1
HKD2_k127_2841902_1	1499683.CCFF01000014_gene3680	2.311e-73	264.0	COG1266@1|root,COG1266@2|Bacteria,1UKRN@1239|Firmicutes,25G1X@186801|Clostridia	186801|Clostridia	S	CAAX protease self-immunity	-	-	-	-	-	-	-	-	-	-	-	-	Abi
HKD2_k127_2841902_3	642492.Clole_0362	4.715e-26	107.0	COG1233@1|root,COG1233@2|Bacteria,1TS4A@1239|Firmicutes,249K1@186801|Clostridia	186801|Clostridia	Q	FAD dependent oxidoreductase	-	-	1.3.99.26,1.3.99.28,1.3.99.29,1.3.99.31	ko:K10027	ko00906,ko01100,ko01110,map00906,map01100,map01110	-	R04787,R04798,R04800,R09691,R09692	RC01214,RC02088,RC02605	ko00000,ko00001,ko01000	-	-	-	Amino_oxidase
HKD2_k127_2877174_6	1408303.JNJJ01000048_gene2700	1.961e-23	103.0	COG0840@1|root,COG0840@2|Bacteria,1TP5A@1239|Firmicutes,4H9RZ@91061|Bacilli	91061|Bacilli	NT	chemotaxis protein	mcpB3	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	HAMP,MCPsignal,dCache_1
HKD2_k127_2877174_0	1294142.CINTURNW_3551	1.001e-226	721.0	arCOG08054@1|root,2Z8AD@2|Bacteria,1TQ1J@1239|Firmicutes,2485U@186801|Clostridia,36EH0@31979|Clostridiaceae	186801|Clostridia	S	Carbohydrate-binding domain-containing protein Cthe_2159	-	GO:0001871,GO:0003674,GO:0005488,GO:0005509,GO:0030246,GO:0030247,GO:0030248,GO:0043167,GO:0043169,GO:0046872,GO:0048028,GO:2001062	-	-	-	-	-	-	-	-	-	-	Cthe_2159
HKD2_k127_2877174_4	1499968.TCA2_2889	2.315e-85	289.0	COG1285@1|root,COG1285@2|Bacteria,1V1GI@1239|Firmicutes,4HGIX@91061|Bacilli,274V3@186822|Paenibacillaceae	91061|Bacilli	S	Cell division protein FtsZ	XK27_05505	-	-	-	-	-	-	-	-	-	-	-	DUF4956
HKD2_k127_2877174_3	755731.Clo1100_3154	8.374e-105	346.0	COG5036@1|root,COG5036@2|Bacteria,1V1FZ@1239|Firmicutes,24FRH@186801|Clostridia,36I9C@31979|Clostridiaceae	186801|Clostridia	P	VTC domain	-	-	-	-	-	-	-	-	-	-	-	-	VTC
HKD2_k127_2877174_2	1209989.TepiRe1_2200	2.854e-111	362.0	COG0745@1|root,COG0745@2|Bacteria,1TS81@1239|Firmicutes,248XH@186801|Clostridia,42G7G@68295|Thermoanaerobacterales	186801|Clostridia	K	PFAM response regulator receiver	mprA	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
HKD2_k127_2877174_1	293826.Amet_1992	9.989e-161	515.0	COG5002@1|root,COG5002@2|Bacteria,1TS83@1239|Firmicutes,249CD@186801|Clostridia,36E81@31979|Clostridiaceae	186801|Clostridia	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
HKD2_k127_2877174_5	767817.Desgi_3255	6.072e-53	192.0	COG2761@1|root,COG2761@2|Bacteria,1TRSS@1239|Firmicutes,25D1S@186801|Clostridia	186801|Clostridia	Q	DSBA-like thioredoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	DSBA
HKD2_k127_2882325_2	1123252.ATZF01000002_gene2349	1.092e-10	73.0	COG2602@1|root,COG2602@2|Bacteria,1VZ0X@1239|Firmicutes,4HTVD@91061|Bacilli	91061|Bacilli	V	Penicillin binding protein transpeptidase domain	ybxI	-	3.5.2.6	ko:K17838	ko01501,map01501	-	R06363	RC01499	ko00000,ko00001,ko01000	-	-	-	Transpeptidase
HKD2_k127_2882325_1	748727.CLJU_c14900	4.016e-33	142.0	COG0657@1|root,COG0657@2|Bacteria,1UFB9@1239|Firmicutes,24DFS@186801|Clostridia,36HTV@31979|Clostridiaceae	186801|Clostridia	I	Dienelactone hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	DLH
HKD2_k127_2882325_0	748727.CLJU_c38790	1.068e-150	482.0	COG0042@1|root,COG0042@2|Bacteria,1TRJM@1239|Firmicutes,247R5@186801|Clostridia,36DKJ@31979|Clostridiaceae	186801|Clostridia	H	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines	-	-	-	-	-	-	-	-	-	-	-	-	Dus
HKD2_k127_2882325_3	189426.PODO_29670	1.593e-07	55.0	COG3568@1|root,COG3568@2|Bacteria,1U5BI@1239|Firmicutes,4HE49@91061|Bacilli,26S8P@186822|Paenibacillaceae	91061|Bacilli	S	endonuclease exonuclease phosphatase family protein	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
HKD2_k127_2897807_1	1304284.L21TH_0180	3.204e-179	568.0	COG0665@1|root,COG0665@2|Bacteria,1VTRW@1239|Firmicutes,25F1Y@186801|Clostridia,36GPM@31979|Clostridiaceae	186801|Clostridia	E	FAD dependent oxidoreductase	-	-	1.5.3.1	ko:K00303	ko00260,ko01100,map00260,map01100	-	R00610	RC00060,RC00557	ko00000,ko00001,ko01000	-	-	-	DAO
HKD2_k127_2897807_8	1408422.JHYF01000004_gene1722	1.667e-50	181.0	COG1142@1|root,COG1142@2|Bacteria,1VJF0@1239|Firmicutes,25HHZ@186801|Clostridia	186801|Clostridia	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_4
HKD2_k127_2897807_0	1487923.DP73_09790	0.0	1201.0	COG2414@1|root,COG2414@2|Bacteria,1TPT9@1239|Firmicutes,2481Q@186801|Clostridia,260VN@186807|Peptococcaceae	186801|Clostridia	C	Aldehyde ferredoxin	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
HKD2_k127_2897807_10	1408422.JHYF01000004_gene1724	3.071e-23	100.0	COG2104@1|root,COG2104@2|Bacteria,1VKB4@1239|Firmicutes	1239|Firmicutes	H	thiamine biosynthesis protein ThiS	thiS	-	-	ko:K03154	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
HKD2_k127_2897807_4	857293.CAAU_0236	1.294e-135	437.0	COG1210@1|root,COG1210@2|Bacteria,1TQ24@1239|Firmicutes,25E5A@186801|Clostridia,36EIH@31979|Clostridiaceae	186801|Clostridia	M	UTP-glucose-1-phosphate uridylyltransferase	galU	-	2.7.7.9	ko:K00963	ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130	M00129,M00361,M00362,M00549	R00289	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS02205	NTP_transferase
HKD2_k127_2897807_6	1150474.JQJI01000004_gene436	2.293e-113	374.0	COG1087@1|root,COG1087@2|Bacteria,2GCQI@200918|Thermotogae	200918|Thermotogae	M	Belongs to the NAD(P)-dependent epimerase dehydratase family	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
HKD2_k127_2897807_2	431943.CKL_2099	1.825e-154	499.0	COG1004@1|root,COG1004@2|Bacteria,1TQFN@1239|Firmicutes,25B1W@186801|Clostridia,36W7P@31979|Clostridiaceae	186801|Clostridia	M	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	ywqF	-	1.1.1.22	ko:K00012	ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100	M00014,M00129,M00361,M00362	R00286	RC00291	ko00000,ko00001,ko00002,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
HKD2_k127_2897807_3	203119.Cthe_1085	1.39e-147	476.0	COG0438@1|root,COG0438@2|Bacteria,1V2NV@1239|Firmicutes,25ERN@186801|Clostridia	186801|Clostridia	M	PFAM Glycosyl transferase, group 1	-	-	2.4.1.348	ko:K06338,ko:K12995	-	-	-	-	ko00000,ko01000,ko01003,ko01005	-	GT4	-	Glyco_transf_4,Glycos_transf_1
HKD2_k127_2897807_7	203119.Cthe_1084	1.564e-108	361.0	COG2334@1|root,COG2334@2|Bacteria,1TTBS@1239|Firmicutes,2483F@186801|Clostridia	186801|Clostridia	S	spore coat protein, CotS	cotS	-	-	ko:K06331	-	-	-	-	ko00000	-	-	-	APH
HKD2_k127_2897807_5	203119.Cthe_1083	1.27e-121	399.0	COG2334@1|root,COG2334@2|Bacteria,1V035@1239|Firmicutes	1239|Firmicutes	S	coat protein	cotS	-	-	ko:K06337	-	-	-	-	ko00000	-	-	-	APH
HKD2_k127_2897807_9	1347392.CCEZ01000043_gene68	8.864e-35	134.0	COG3981@1|root,COG3981@2|Bacteria,1V1C4@1239|Firmicutes,25B3M@186801|Clostridia,36W86@31979|Clostridiaceae	186801|Clostridia	S	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_3
HKD2_k127_290421_1	632292.Calhy_2344	6.556e-47	176.0	COG1172@1|root,COG1172@2|Bacteria,1V9PU@1239|Firmicutes,24PGN@186801|Clostridia	186801|Clostridia	G	Branched-chain amino acid transport system / permease component	-	-	-	ko:K10440	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	BPD_transp_2
HKD2_k127_290421_0	994573.T472_0201725	3.005e-255	795.0	COG1472@1|root,COG1472@2|Bacteria,1TP63@1239|Firmicutes,24YIP@186801|Clostridia,36W7H@31979|Clostridiaceae	186801|Clostridia	G	hydrolase, family 3	-	-	3.2.1.52	ko:K01207	ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501	M00628	R00022,R05963,R07809,R07810,R10831	RC00049	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyco_hydro_3
HKD2_k127_2914189_4	536232.CLM_1963	1.34e-42	163.0	COG2334@1|root,COG2334@2|Bacteria,1VRRV@1239|Firmicutes,248GC@186801|Clostridia,36GNT@31979|Clostridiaceae	186801|Clostridia	S	Spore coat protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2914189_2	203119.Cthe_0611	1.676e-174	565.0	COG1236@1|root,COG1236@2|Bacteria,1TQBH@1239|Firmicutes,248QR@186801|Clostridia,3WHA0@541000|Ruminococcaceae	186801|Clostridia	J	Metallo-beta-lactamase domain protein	-	-	-	ko:K07576	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B,Lactamase_B_6,RMMBL
HKD2_k127_2914189_5	706587.Desti_3465	7.969e-30	126.0	2CI1U@1|root,32X07@2|Bacteria,1RHG4@1224|Proteobacteria,42SM5@68525|delta/epsilon subdivisions,2WPX4@28221|Deltaproteobacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2914189_1	720554.Clocl_1740	2.517e-181	579.0	COG0621@1|root,COG0621@2|Bacteria,1TNYN@1239|Firmicutes,2482Y@186801|Clostridia,3WGSQ@541000|Ruminococcaceae	186801|Clostridia	J	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine	miaB	-	2.8.4.3	ko:K06168	-	-	R10645,R10646,R10647	RC00003,RC00980,RC03221,RC03222	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
HKD2_k127_2914189_0	394503.Ccel_1697	2.103e-308	967.0	COG0249@1|root,COG0249@2|Bacteria,1TPRJ@1239|Firmicutes,248GI@186801|Clostridia,36DR6@31979|Clostridiaceae	186801|Clostridia	L	that it carries out the mismatch recognition step. This protein has a weak ATPase activity	mutS	-	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
HKD2_k127_2914189_3	1304284.L21TH_0884	1.07e-147	488.0	COG0323@1|root,COG0323@2|Bacteria,1TPGK@1239|Firmicutes,24902@186801|Clostridia,36EVN@31979|Clostridiaceae	186801|Clostridia	L	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex	mutL	-	-	ko:K03572	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	DNA_mis_repair,HATPase_c_3,MutL_C
HKD2_k127_2914625_0	1304880.JAGB01000001_gene353	0.0	1020.0	COG0587@1|root,COG0587@2|Bacteria,1TPYG@1239|Firmicutes,247U0@186801|Clostridia	186801|Clostridia	L	DNA polymerase III, alpha subunit	dnaE	-	2.7.7.7	ko:K02337,ko:K14162	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
HKD2_k127_2914625_8	720554.Clocl_2230	2.832e-19	89.0	2E53P@1|root,32ZWQ@2|Bacteria,1VF3E@1239|Firmicutes,24QUX@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF2007
HKD2_k127_2914625_4	1304284.L21TH_1092	6.864e-137	442.0	COG0205@1|root,COG0205@2|Bacteria,1TPF4@1239|Firmicutes,248PB@186801|Clostridia,36DGA@31979|Clostridiaceae	186801|Clostridia	F	Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis	pfkA	-	2.7.1.11	ko:K00850	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230	M00001,M00345	R00756,R03236,R03237,R03238,R03239,R04779	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000,ko01009,ko03019	-	-	-	PFK
HKD2_k127_2914625_3	521460.Athe_1824	1.546e-149	484.0	COG0205@1|root,COG0205@2|Bacteria,1TRJQ@1239|Firmicutes,247IV@186801|Clostridia,42EM1@68295|Thermoanaerobacterales	186801|Clostridia	H	Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions	pfp	-	2.7.1.11,2.7.1.90	ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
HKD2_k127_2914625_1	580327.Tthe_0771	1.98e-226	715.0	COG0469@1|root,COG0469@2|Bacteria,1TPGG@1239|Firmicutes,2489V@186801|Clostridia,42F1S@68295|Thermoanaerobacterales	186801|Clostridia	G	Belongs to the pyruvate kinase family	pyk	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PEP-utilizers,PK,PK_C
HKD2_k127_2914625_7	293826.Amet_4064	4.597e-32	131.0	COG0824@1|root,COG0824@2|Bacteria,1VAGM@1239|Firmicutes,24NBX@186801|Clostridia,36JT8@31979|Clostridiaceae	186801|Clostridia	S	acyl-CoA thioester hydrolase, YbgC YbaW family	FcbC	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT,4HBT_2
HKD2_k127_2914625_5	717605.Theco_1130	8.995e-100	336.0	COG2309@1|root,COG2309@2|Bacteria,1TP65@1239|Firmicutes,4H9W8@91061|Bacilli,26RHU@186822|Paenibacillaceae	91061|Bacilli	E	peptidase M29	pepS	-	-	ko:K19689	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M29
HKD2_k127_2914625_6	1196322.A370_00610	4.053e-41	159.0	COG4420@1|root,COG4420@2|Bacteria,1V46X@1239|Firmicutes,24JQK@186801|Clostridia,36IE2@31979|Clostridiaceae	186801|Clostridia	S	Protein of unknown function (DUF1003)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1003
HKD2_k127_2914625_2	1487921.DP68_11170	2.722e-160	515.0	COG2265@1|root,COG2265@2|Bacteria,1TP4H@1239|Firmicutes,248B4@186801|Clostridia,36EBZ@31979|Clostridiaceae	186801|Clostridia	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family	rumA	-	2.1.1.190	ko:K03215	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TRAM,tRNA_U5-meth_tr
HKD2_k127_2914625_9	641107.CDLVIII_3908	2.232e-12	69.0	COG0655@1|root,COG0655@2|Bacteria,1UYQ4@1239|Firmicutes,249HT@186801|Clostridia,36FHX@31979|Clostridiaceae	186801|Clostridia	S	PFAM NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
HKD2_k127_2929214_4	1499689.CCNN01000007_gene917	1.16e-83	281.0	COG1670@1|root,COG1670@2|Bacteria,1V2C6@1239|Firmicutes,24IXM@186801|Clostridia,36KEH@31979|Clostridiaceae	186801|Clostridia	J	Acetyltransferase (GNAT) domain	-	-	2.3.1.128	ko:K03790	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_3
HKD2_k127_2929214_14	1385510.N781_04450	8.939e-28	122.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	2.1.1.301	ko:K21459	-	-	-	-	ko00000,ko01000	-	-	-	Methyltransf_25
HKD2_k127_2929214_3	195103.CPF_0983	6.3e-87	294.0	COG1082@1|root,COG1082@2|Bacteria,1UIRS@1239|Firmicutes,25EQK@186801|Clostridia,36J8P@31979|Clostridiaceae	186801|Clostridia	G	Xylose isomerase domain protein TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2929214_15	1347392.CCEZ01000074_gene1835	1.919e-24	109.0	COG2320@1|root,COG2320@2|Bacteria,1V3IB@1239|Firmicutes,24F56@186801|Clostridia,36VN9@31979|Clostridiaceae	186801|Clostridia	S	GrpB protein	-	-	-	-	-	-	-	-	-	-	-	-	GrpB
HKD2_k127_2929214_8	1395513.P343_16975	5.407e-59	207.0	COG0454@1|root,COG0456@2|Bacteria,1V4GU@1239|Firmicutes,4HQNT@91061|Bacilli	91061|Bacilli	K	GCN5 family acetyltransferase	-	-	2.3.1.1	ko:K22477	ko00220,ko01210,ko01230,map00220,map01210,map01230	M00028	R00259	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetyltransf_1
HKD2_k127_2929214_13	748727.CLJU_c23170	1.177e-28	121.0	2DCD7@1|root,2ZDR5@2|Bacteria,1UTW0@1239|Firmicutes,254KK@186801|Clostridia,36TXX@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2929214_0	1321778.HMPREF1982_01725	1.949e-208	654.0	COG1680@1|root,COG1680@2|Bacteria,1TRR5@1239|Firmicutes,249KP@186801|Clostridia	186801|Clostridia	V	beta-lactamase	-	-	3.4.16.4	ko:K01286	-	-	-	-	ko00000,ko01000	-	-	-	Beta-lactamase,Cu_amine_oxidN1,DUF3471,Gram_pos_anchor
HKD2_k127_2929214_10	398512.JQKC01000013_gene1441	1.177e-57	209.0	COG1994@1|root,COG1994@2|Bacteria,1VYB9@1239|Firmicutes,251K0@186801|Clostridia	186801|Clostridia	S	Peptidase M50	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2929214_16	768706.Desor_2228	3.817e-13	71.0	2EVSE@1|root,33P6B@2|Bacteria,1VNPB@1239|Firmicutes	1239|Firmicutes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2929214_1	646529.Desaci_0293	2.258e-108	355.0	COG0639@1|root,COG0639@2|Bacteria,1UZK9@1239|Firmicutes,24IKE@186801|Clostridia	186801|Clostridia	T	Calcineurin-like phosphoesterase superfamily domain	-	-	3.1.3.16	ko:K01090	-	-	-	-	ko00000,ko01000	-	-	-	Metallophos_2
HKD2_k127_2929214_17	660470.Theba_0632	6.289e-05	46.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	ubiE_2	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_12,Methyltransf_23,Methyltransf_25,Methyltransf_31
HKD2_k127_2929214_12	273068.TTE1369	5.542e-49	185.0	COG0613@1|root,COG0613@2|Bacteria,1TPI5@1239|Firmicutes,248H2@186801|Clostridia,42GGH@68295|Thermoanaerobacterales	186801|Clostridia	S	SMART phosphoesterase PHP domain protein	trpH	-	3.1.3.97	ko:K07053	-	-	R00188,R11188	RC00078	ko00000,ko01000	-	-	-	PHP
HKD2_k127_2929214_7	1211817.CCAT010000065_gene548	2.047e-63	221.0	COG1670@1|root,COG1670@2|Bacteria,1VABF@1239|Firmicutes	1239|Firmicutes	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
HKD2_k127_2929214_6	272562.CA_C2487	3.501e-80	270.0	COG3981@1|root,COG3981@2|Bacteria,1VA6C@1239|Firmicutes,24HZ2@186801|Clostridia,36INJ@31979|Clostridiaceae	186801|Clostridia	S	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
HKD2_k127_2929214_2	536227.CcarbDRAFT_3732	1.104e-93	309.0	COG0693@1|root,COG0693@2|Bacteria,1V1CG@1239|Firmicutes,25CHN@186801|Clostridia,36JP5@31979|Clostridiaceae	186801|Clostridia	S	DJ-1/PfpI family	pfpI	-	3.5.1.124	ko:K05520	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	DJ-1_PfpI
HKD2_k127_2929214_11	1294142.CINTURNW_1134	4.963e-54	199.0	COG3393@1|root,COG3393@2|Bacteria,1TRN7@1239|Firmicutes,24A2B@186801|Clostridia,36HV9@31979|Clostridiaceae	186801|Clostridia	S	GNAT acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,GNAT_acetyltran
HKD2_k127_2929214_9	642492.Clole_3887	2.987e-58	207.0	COG3871@1|root,COG3871@2|Bacteria	2|Bacteria	S	Pyridoxamine 5'-phosphate oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx,Pyrid_ox_like,Zn_ribbon_2
HKD2_k127_2929214_5	1449050.JNLE01000003_gene349	1.099e-81	276.0	COG0500@1|root,COG0500@2|Bacteria,1V0PR@1239|Firmicutes,25E3Q@186801|Clostridia,36GBK@31979|Clostridiaceae	186801|Clostridia	Q	Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
HKD2_k127_2932070_2	1321778.HMPREF1982_02867	3.028e-115	373.0	COG0444@1|root,COG0444@2|Bacteria,1TP6E@1239|Firmicutes,247NN@186801|Clostridia	186801|Clostridia	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031,ko:K15583	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
HKD2_k127_2932070_1	1321778.HMPREF1982_02866	5.891e-183	575.0	COG1173@1|root,COG1173@2|Bacteria,1UZX1@1239|Firmicutes,249KN@186801|Clostridia	186801|Clostridia	EP	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
HKD2_k127_2932070_0	1321778.HMPREF1982_02865	4.798e-203	634.0	COG0601@1|root,COG0601@2|Bacteria,1TP1S@1239|Firmicutes,247IP@186801|Clostridia	186801|Clostridia	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
HKD2_k127_2932070_3	1321778.HMPREF1982_02864	1.402e-16	78.0	COG0747@1|root,COG0747@2|Bacteria,1TPPC@1239|Firmicutes,24BKZ@186801|Clostridia	186801|Clostridia	E	Extracellular solute-binding protein, family 5	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
HKD2_k127_295815_0	941824.TCEL_00481	4.18e-239	742.0	COG0436@1|root,COG0436@2|Bacteria,1TRA9@1239|Firmicutes,249X4@186801|Clostridia,36GQW@31979|Clostridiaceae	186801|Clostridia	E	Alanine-glyoxylate amino-transferase	-	-	2.6.1.1	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
HKD2_k127_295815_3	293826.Amet_1434	1.486e-76	262.0	COG3797@1|root,COG3797@2|Bacteria,1V426@1239|Firmicutes,24HUG@186801|Clostridia,36WZF@31979|Clostridiaceae	186801|Clostridia	S	Protein of unknown function (DUF1697)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1697
HKD2_k127_295815_1	350688.Clos_2754	3.316e-105	346.0	2CET8@1|root,2Z7N2@2|Bacteria,1TT9T@1239|Firmicutes,24AN8@186801|Clostridia,36IKU@31979|Clostridiaceae	186801|Clostridia	S	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_295815_2	1487921.DP68_04595	1.919e-96	317.0	COG1578@1|root,COG1578@2|Bacteria,1UURD@1239|Firmicutes,2492C@186801|Clostridia,36GFY@31979|Clostridiaceae	186801|Clostridia	S	Protein of unknown function DUF89	-	-	-	ko:K09116	-	-	-	-	ko00000	-	-	-	DUF89
HKD2_k127_29797_2	1121289.JHVL01000003_gene2174	2.065e-66	235.0	COG0196@1|root,COG0196@2|Bacteria,1TPKS@1239|Firmicutes,2484A@186801|Clostridia,36EA2@31979|Clostridiaceae	186801|Clostridia	H	Belongs to the ribF family	ribF	-	2.7.1.26,2.7.7.2	ko:K11753	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00161,R00549	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_syn,Flavokinase
HKD2_k127_29797_3	553973.CLOHYLEM_06705	2.42e-33	130.0	COG0184@1|root,COG0184@2|Bacteria,1VA5C@1239|Firmicutes,24MRM@186801|Clostridia,220GG@1506553|Lachnoclostridium	186801|Clostridia	J	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome	rpsO	-	-	ko:K02956	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S15
HKD2_k127_29797_0	445973.CLOBAR_02156	1.35e-294	919.0	COG1185@1|root,COG1185@2|Bacteria,1TQDW@1239|Firmicutes,248RW@186801|Clostridia,25QG3@186804|Peptostreptococcaceae	186801|Clostridia	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	-	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
HKD2_k127_29797_1	290402.Cbei_2724	6.637e-112	376.0	COG3973@1|root,COG3973@2|Bacteria,1TP39@1239|Firmicutes,249IG@186801|Clostridia,36E3M@31979|Clostridiaceae	186801|Clostridia	L	DNA helicase	-	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AAA_19,UvrD-helicase,UvrD_C,UvrD_C_2
HKD2_k127_3007187_1	1469948.JPNB01000001_gene877	1.553e-31	130.0	COG1172@1|root,COG1172@2|Bacteria,1TP72@1239|Firmicutes,249FA@186801|Clostridia,36DTM@31979|Clostridiaceae	186801|Clostridia	G	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K10440,ko:K17214	ko02010,map02010	M00212,M00593	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2,3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	BPD_transp_2
HKD2_k127_3007187_0	1469948.JPNB01000001_gene876	3.757e-187	597.0	COG1129@1|root,COG1129@2|Bacteria,1TP6I@1239|Firmicutes,247II@186801|Clostridia,36DME@31979|Clostridiaceae	186801|Clostridia	P	import. Responsible for energy coupling to the transport system	-	-	3.6.3.17	ko:K10441	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	ABC_tran
HKD2_k127_3007187_2	1469948.JPNB01000001_gene875	2.874e-11	68.0	COG1879@1|root,COG1879@2|Bacteria	2|Bacteria	G	ABC-type sugar transport system periplasmic component	-	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_4
HKD2_k127_3017994_13	941824.TCEL_01603	1.649e-51	190.0	COG2843@1|root,COG2843@2|Bacteria,1UCFI@1239|Firmicutes,25CHR@186801|Clostridia,36FAR@31979|Clostridiaceae	186801|Clostridia	M	Capsule synthesis protein	capA	-	-	ko:K07282	-	-	-	-	ko00000	-	-	-	PGA_cap,Peptidase_M15
HKD2_k127_3017994_12	868595.Desca_0382	1.436e-54	194.0	COG0517@1|root,COG0517@2|Bacteria,1V7XE@1239|Firmicutes,24HF5@186801|Clostridia,261Z8@186807|Peptococcaceae	186801|Clostridia	S	PFAM CBS domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS
HKD2_k127_3017994_5	293826.Amet_3694	3.302e-102	341.0	COG0697@1|root,COG0697@2|Bacteria,1TYSF@1239|Firmicutes,25CFG@186801|Clostridia,36WV6@31979|Clostridiaceae	186801|Clostridia	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HKD2_k127_3017994_16	879308.HMPREF9130_1200	2.491e-18	90.0	COG0011@1|root,COG0011@2|Bacteria,1VBWM@1239|Firmicutes,25DPD@186801|Clostridia	186801|Clostridia	S	Thiamine-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	Thiamine_BP
HKD2_k127_3017994_6	1304284.L21TH_1284	4.036e-102	338.0	COG0600@1|root,COG0600@2|Bacteria,1TRFD@1239|Firmicutes,25C7Z@186801|Clostridia,36DV8@31979|Clostridiaceae	186801|Clostridia	P	ABC-type nitrate sulfonate bicarbonate transport system, permease component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
HKD2_k127_3017994_1	1304284.L21TH_1283	4.485e-155	495.0	COG0715@1|root,COG0715@2|Bacteria,1TPAD@1239|Firmicutes,24A2V@186801|Clostridia,36FHT@31979|Clostridiaceae	186801|Clostridia	P	ABC-type nitrate sulfonate bicarbonate transport	-	-	-	-	-	-	-	-	-	-	-	-	NMT1
HKD2_k127_3017994_4	1121289.JHVL01000023_gene88	1.75e-110	362.0	COG1116@1|root,COG1116@2|Bacteria,1TSW5@1239|Firmicutes,25AZG@186801|Clostridia,36GVM@31979|Clostridiaceae	186801|Clostridia	P	ABC-type nitrate sulfonate bicarbonate transport system ATPase component	-	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
HKD2_k127_3017994_9	1304284.L21TH_1281	9.315e-87	292.0	COG0500@1|root,COG2226@2|Bacteria,1UY28@1239|Firmicutes,24GXH@186801|Clostridia,36IJZ@31979|Clostridiaceae	186801|Clostridia	Q	Methionine biosynthesis protein MetW	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
HKD2_k127_3017994_14	1236976.JCM16418_3851	6.096e-42	158.0	COG2204@1|root,COG2204@2|Bacteria,1UHXE@1239|Firmicutes,4ISDB@91061|Bacilli,26XDQ@186822|Paenibacillaceae	91061|Bacilli	T	Chemotaxis protein CheY	cheY	-	-	ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	Response_reg
HKD2_k127_3017994_3	1540257.JQMW01000009_gene3847	9.831e-131	423.0	COG1131@1|root,COG1131@2|Bacteria,1TPMQ@1239|Firmicutes,248QD@186801|Clostridia,36DTX@31979|Clostridiaceae	186801|Clostridia	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
HKD2_k127_3017994_11	293826.Amet_4205	8.479e-79	278.0	COG0842@1|root,COG0842@2|Bacteria,1V9DR@1239|Firmicutes,25B2R@186801|Clostridia,36W72@31979|Clostridiaceae	186801|Clostridia	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
HKD2_k127_3017994_10	1540257.JQMW01000009_gene3845	1.356e-79	279.0	COG0842@1|root,COG0842@2|Bacteria,1UZU6@1239|Firmicutes,24BPW@186801|Clostridia,36DU4@31979|Clostridiaceae	186801|Clostridia	V	ABC-2 type transporter	sagI	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
HKD2_k127_3017994_7	293826.Amet_4203	4.31e-96	326.0	COG4585@1|root,COG4585@2|Bacteria,1UUZ9@1239|Firmicutes,248T2@186801|Clostridia,36W11@31979|Clostridiaceae	186801|Clostridia	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HisKA_3,HisKA_7TM
HKD2_k127_3017994_8	913865.DOT_4884	4.881e-89	297.0	COG2197@1|root,COG2197@2|Bacteria,1TRXG@1239|Firmicutes,24FZX@186801|Clostridia,2625D@186807|Peptococcaceae	186801|Clostridia	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HKD2_k127_3017994_15	1078085.HMPREF1210_02818	2.593e-28	117.0	2E6WB@1|root,331FV@2|Bacteria,1VF7B@1239|Firmicutes,4HNST@91061|Bacilli	91061|Bacilli	S	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3017994_2	1540257.JQMW01000011_gene1816	3.181e-133	435.0	COG0053@1|root,COG0053@2|Bacteria,1TSGY@1239|Firmicutes,2491V@186801|Clostridia,36ECU@31979|Clostridiaceae	186801|Clostridia	P	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family	czcD	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,ZT_dimer
HKD2_k127_3017994_0	1304284.L21TH_0784	0.0	1372.0	COG0060@1|root,COG0060@2|Bacteria,1TPS7@1239|Firmicutes,247XX@186801|Clostridia,36DSA@31979|Clostridiaceae	186801|Clostridia	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
HKD2_k127_3022462_0	702450.CUW_1779	1.339e-128	425.0	COG0770@1|root,COG0770@2|Bacteria,1VT78@1239|Firmicutes,3VP1W@526524|Erysipelotrichia	526524|Erysipelotrichia	M	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein	murF	-	6.3.2.10	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	-	R04573,R04617	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
HKD2_k127_3022462_1	180332.JTGN01000006_gene3179	2.217e-68	240.0	COG4209@1|root,COG4209@2|Bacteria,1TP33@1239|Firmicutes,248XU@186801|Clostridia	186801|Clostridia	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K17319	ko02010,map02010	M00603	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.29,3.A.1.1.9	-	-	BPD_transp_1
HKD2_k127_3032404_13	1211819.CALK01000021_gene757	5.703e-61	214.0	COG0444@1|root,COG0444@2|Bacteria,1TP6E@1239|Firmicutes,3VNWI@526524|Erysipelotrichia	526524|Erysipelotrichia	P	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
HKD2_k127_3032404_6	1211819.CALK01000021_gene756	3.01e-124	406.0	COG4608@1|root,COG4608@2|Bacteria,1V36J@1239|Firmicutes,3VNY3@526524|Erysipelotrichia	526524|Erysipelotrichia	P	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,oligo_HPY
HKD2_k127_3032404_4	1122921.KB898188_gene29	1.673e-134	446.0	COG0747@1|root,COG0747@2|Bacteria,1TQ0N@1239|Firmicutes,4HUAW@91061|Bacilli,26QAC@186822|Paenibacillaceae	91061|Bacilli	E	ABC transporter substrate-binding protein	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
HKD2_k127_3032404_3	333138.LQ50_15340	4.297e-135	445.0	COG2866@1|root,COG2866@2|Bacteria,1UZHE@1239|Firmicutes,4HEJP@91061|Bacilli	91061|Bacilli	E	Zinc carboxypeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M14
HKD2_k127_3032404_5	665956.HMPREF1032_00456	1.812e-129	427.0	COG0534@1|root,COG0534@2|Bacteria,1TNZN@1239|Firmicutes,247YX@186801|Clostridia,3WH49@541000|Ruminococcaceae	186801|Clostridia	V	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	MatE
HKD2_k127_3032404_7	1157490.EL26_11975	9.476e-107	371.0	COG2234@1|root,COG2234@2|Bacteria	2|Bacteria	DZ	aminopeptidase activity	-	-	-	ko:K07004	-	-	-	-	ko00000	-	-	-	PKD,PPC,Peptidase_M10,Peptidase_M28,SLH
HKD2_k127_3032404_15	908337.HMPREF9257_0645	2.111e-52	199.0	COG1473@1|root,COG1473@2|Bacteria,1TSCA@1239|Firmicutes,4HCHT@91061|Bacilli,27EI7@186827|Aerococcaceae	91061|Bacilli	S	Peptidase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
HKD2_k127_3032404_0	762966.HMPREF9439_02713	9.008e-277	874.0	COG0243@1|root,COG0243@2|Bacteria,1NR6J@1224|Proteobacteria,2VHHZ@28216|Betaproteobacteria,4PRI1@995019|Sutterellaceae	2|Bacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Molybdopterin,Molydop_binding
HKD2_k127_3032404_8	522772.Dacet_0678	3.129e-77	265.0	COG0437@1|root,COG0437@2|Bacteria,2GGE2@200930|Deferribacteres	200930|Deferribacteres	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_11
HKD2_k127_3032404_17	400682.PAC_15706812	9.04e-40	160.0	COG0666@1|root,KOG0504@2759|Eukaryota	2759|Eukaryota	I	protein ubiquitination	-	-	-	ko:K15503,ko:K21440	-	-	-	-	ko00000,ko01009,ko03400,ko04131	-	-	-	Ank,Ank_2,Ank_3,Ank_4,Ank_5
HKD2_k127_3032404_2	880073.Calab_2883	7.881e-166	534.0	COG0493@1|root,COG0493@2|Bacteria,2NNUI@2323|unclassified Bacteria	2|Bacteria	E	Flavin containing amine oxidoreductase	gltD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	iJN678.gltD,iNJ661.Rv3858c,iSB619.SA_RS02450	Fer4_20,Pyr_redox_2
HKD2_k127_3032404_16	264732.Moth_2174	2.366e-43	165.0	COG0746@1|root,COG0746@2|Bacteria,1VA6T@1239|Firmicutes,24JG6@186801|Clostridia,42GTS@68295|Thermoanaerobacterales	186801|Clostridia	H	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor	mobA	-	2.7.7.77	ko:K03752,ko:K13818	ko00790,ko01100,map00790,map01100	-	R11581	-	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
HKD2_k127_3032404_22	1195236.CTER_3654	1.71e-05	48.0	2DG44@1|root,2ZUDU@2|Bacteria,1W1K6@1239|Firmicutes,24QWW@186801|Clostridia	186801|Clostridia	S	Spo0E like sporulation regulatory protein	-	-	-	-	-	-	-	-	-	-	-	-	SpoOE-like
HKD2_k127_3032404_11	926692.AZYG01000018_gene324	5.57e-65	233.0	COG4294@1|root,COG4294@2|Bacteria,1TTCB@1239|Firmicutes,24BHY@186801|Clostridia,3WBKP@53433|Halanaerobiales	186801|Clostridia	L	UV-endonuclease UvdE	uvdE	-	-	ko:K13281	-	-	-	-	ko00000,ko01000	-	-	-	UvdE
HKD2_k127_3032404_21	279010.BL04038	8.307e-07	55.0	2EKMP@1|root,33EBE@2|Bacteria,1VQNN@1239|Firmicutes,4HSNG@91061|Bacilli,1ZG44@1386|Bacillus	91061|Bacilli	S	Family of unknown function (DUF5362)	ywnC	-	-	-	-	-	-	-	-	-	-	-	DUF5362
HKD2_k127_3032404_14	1196322.A370_00089	1.27e-57	209.0	COG1234@1|root,COG1234@2|Bacteria,1V1J7@1239|Firmicutes,24F18@186801|Clostridia,36G02@31979|Clostridiaceae	186801|Clostridia	S	beta-lactamase superfamily III	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B,Lactamase_B_2,UPF0227
HKD2_k127_3032404_23	1247024.JRLH01000016_gene1694	0.0008007	44.0	2EG8N@1|root,33A0G@2|Bacteria,1NHU3@1224|Proteobacteria,1SECH@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3032404_9	1195236.CTER_2544	7.195e-77	268.0	COG1196@1|root,COG1196@2|Bacteria,1V2X5@1239|Firmicutes	1239|Firmicutes	D	nuclear chromosome segregation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3032404_10	68194.JNXR01000015_gene8073	3.356e-66	235.0	COG2013@1|root,COG2013@2|Bacteria,2I9XC@201174|Actinobacteria	201174|Actinobacteria	S	Mitochondrial biogenesis AIM24	-	-	-	-	-	-	-	-	-	-	-	-	AIM24
HKD2_k127_3032404_1	203119.Cthe_0332	7.113e-196	625.0	COG0572@1|root,COG0572@2|Bacteria,1TQ4V@1239|Firmicutes,249IT@186801|Clostridia,3WI74@541000|Ruminococcaceae	186801|Clostridia	F	Phosphoribulokinase uridine kinase family	udk	-	2.7.1.48	ko:K00876	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R00513,R00516,R00517,R00962,R00964,R00967,R00968,R00970,R01548,R01549,R01880,R02091,R02096,R02097,R02327,R02332,R02371,R02372,R08232	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PRK
HKD2_k127_3032404_19	1410653.JHVC01000008_gene2910	5.012e-14	80.0	2E3PR@1|root,32YMT@2|Bacteria,1V4P3@1239|Firmicutes,24R3A@186801|Clostridia,36MVD@31979|Clostridiaceae	186801|Clostridia	S	Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ)	-	-	-	-	-	-	-	-	-	-	-	-	Spore_YhcN_YlaJ
HKD2_k127_3032404_12	1123009.AUID01000009_gene526	4.514e-62	226.0	COG0697@1|root,COG0697@2|Bacteria,1W76A@1239|Firmicutes,25N6Z@186801|Clostridia,26C4P@186813|unclassified Clostridiales	186801|Clostridia	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HKD2_k127_3032404_18	1285586.H131_17126	2.254e-28	117.0	2D04F@1|root,32T7R@2|Bacteria,1VBXI@1239|Firmicutes,4HPEC@91061|Bacilli,3IYTA@400634|Lysinibacillus	91061|Bacilli	S	Protein of unknown function (DUF2500)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2500
HKD2_k127_3032404_20	1123226.KB899289_gene942	2.118e-07	59.0	COG2933@1|root,COG2933@2|Bacteria,1UZA9@1239|Firmicutes,4HDIN@91061|Bacilli,26RGU@186822|Paenibacillaceae	91061|Bacilli	J	SAM-dependent methyltransferase	ygdE	-	2.1.1.186	ko:K06968	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ
HKD2_k127_304758_1	931276.Cspa_c23210	3.814e-113	368.0	COG0613@1|root,COG0613@2|Bacteria,1TPI5@1239|Firmicutes,248H2@186801|Clostridia,36DX7@31979|Clostridiaceae	186801|Clostridia	S	PHP domain	-	-	3.1.3.97	ko:K07053	-	-	R00188,R11188	RC00078	ko00000,ko01000	-	-	-	PHP
HKD2_k127_304758_0	536232.CLM_0625	0.0	1034.0	COG0531@1|root,COG0531@2|Bacteria,1TQE1@1239|Firmicutes,249N1@186801|Clostridia,36E3D@31979|Clostridiaceae	186801|Clostridia	E	amino acid	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
HKD2_k127_304758_2	1121929.KB898665_gene2788	3.974e-60	211.0	2CDA7@1|root,333AV@2|Bacteria,1VHFF@1239|Firmicutes,4ICS8@91061|Bacilli,471Y8@74385|Gracilibacillus	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3091948_3	536232.CLM_0340	3.826e-35	134.0	COG1278@1|root,COG1278@2|Bacteria,1VEE0@1239|Firmicutes,24QJE@186801|Clostridia,36MMP@31979|Clostridiaceae	186801|Clostridia	K	Cold shock protein	-	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
HKD2_k127_3091948_2	1304284.L21TH_1664	8.982e-37	150.0	COG0840@1|root,COG0840@2|Bacteria,1TP5A@1239|Firmicutes,247S3@186801|Clostridia,36EVU@31979|Clostridiaceae	186801|Clostridia	NT	histidine kinase HAMP region domain protein	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	HAMP,MCPsignal,dCache_1,sCache_2
HKD2_k127_3091948_0	1121324.CLIT_5c00530	1.141e-90	304.0	COG2859@1|root,COG2859@2|Bacteria,1V1Q4@1239|Firmicutes,24GEE@186801|Clostridia	186801|Clostridia	L	Protein of unknown function (DUF541)	-	-	-	ko:K09797	-	-	-	-	ko00000	-	-	-	SIMPL
HKD2_k127_3091948_1	697281.Mahau_1177	2.022e-40	159.0	COG2968@1|root,COG2968@2|Bacteria,1VB7C@1239|Firmicutes,24MYD@186801|Clostridia,42HAP@68295|Thermoanaerobacterales	186801|Clostridia	S	Protein of unknown function (DUF541)	-	-	-	ko:K09807	-	-	-	-	ko00000	-	-	-	SIMPL
HKD2_k127_3091948_4	1321778.HMPREF1982_00216	2.71e-28	126.0	COG0642@1|root,COG2205@2|Bacteria,1TQMV@1239|Firmicutes,247SE@186801|Clostridia,26ATW@186813|unclassified Clostridiales	186801|Clostridia	T	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_9,PocR
HKD2_k127_309912_9	335541.Swol_2172	1.324e-68	235.0	COG0477@1|root,COG2814@2|Bacteria	2|Bacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_1_like,Sugar_tr
HKD2_k127_309912_1	1230342.CTM_15817	7.231e-166	533.0	COG0773@1|root,COG0773@2|Bacteria,1TQ5H@1239|Firmicutes,2484K@186801|Clostridia,36DVH@31979|Clostridiaceae	186801|Clostridia	M	Belongs to the MurCDEF family	murC	-	6.3.2.8	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R03193	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
HKD2_k127_309912_7	1121289.JHVL01000059_gene2512	8.679e-90	304.0	COG0503@1|root,COG0503@2|Bacteria,1TPN9@1239|Firmicutes,25CKT@186801|Clostridia,36EDN@31979|Clostridiaceae	186801|Clostridia	F	pur operon repressor	purR	-	-	ko:K09685	-	-	-	-	ko00000,ko03000	-	-	-	Pribosyltran,PuR_N
HKD2_k127_309912_10	86416.Clopa_4594	1.417e-41	154.0	COG2088@1|root,COG2088@2|Bacteria,1V9ZG@1239|Firmicutes,24MVQ@186801|Clostridia,36JKP@31979|Clostridiaceae	186801|Clostridia	D	Could be involved in septation	spoVG	-	-	ko:K06412	-	-	-	-	ko00000	-	-	-	SpoVG
HKD2_k127_309912_5	509191.AEDB02000037_gene2101	6.049e-122	398.0	COG0379@1|root,COG0379@2|Bacteria,1TP6R@1239|Firmicutes,247IJ@186801|Clostridia,3WGEP@541000|Ruminococcaceae	186801|Clostridia	H	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate	nadA	-	2.5.1.72	ko:K03517	ko00760,ko01100,map00760,map01100	M00115	R04292	RC01119	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS12020	NadA
HKD2_k127_309912_3	720554.Clocl_4214	2.719e-160	520.0	COG0029@1|root,COG0029@2|Bacteria,1UHSP@1239|Firmicutes,25E6F@186801|Clostridia,3WGEV@541000|Ruminococcaceae	186801|Clostridia	H	Catalyzes the oxidation of L-aspartate to iminoaspartate	nadB	-	1.4.3.16	ko:K00278	ko00250,ko00760,ko01100,map00250,map00760,map01100	M00115	R00357,R00481	RC00006,RC02566	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
HKD2_k127_309912_6	935948.KE386495_gene1575	2.76e-98	328.0	COG0157@1|root,COG0157@2|Bacteria,1TPQC@1239|Firmicutes,248P2@186801|Clostridia,42F8G@68295|Thermoanaerobacterales	186801|Clostridia	H	Belongs to the NadC ModD family	nadC	-	2.4.2.19	ko:K00767	ko00760,ko01100,map00760,map01100	M00115	R03348	RC02877	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS12010	QRPTase_C,QRPTase_N
HKD2_k127_309912_2	398512.JQKC01000019_gene3438	9.097e-162	522.0	COG1207@1|root,COG1207@2|Bacteria,1TP88@1239|Firmicutes,248Z3@186801|Clostridia,3WGU5@541000|Ruminococcaceae	186801|Clostridia	M	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain	glmU	-	2.3.1.157,2.7.7.23	ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,Hexapep_2,NTP_transf_3,NTP_transferase
HKD2_k127_309912_4	293826.Amet_0157	2.693e-137	442.0	COG0462@1|root,COG0462@2|Bacteria,1TQ6Q@1239|Firmicutes,248ZN@186801|Clostridia,36DE7@31979|Clostridiaceae	186801|Clostridia	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	prs	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyl_synth,Pribosyltran_N
HKD2_k127_309912_8	203119.Cthe_2631	1.698e-72	249.0	COG0193@1|root,COG0193@2|Bacteria,1V3NB@1239|Firmicutes,24HMC@186801|Clostridia,3WIEP@541000|Ruminococcaceae	186801|Clostridia	J	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis	pth	-	3.1.1.29	ko:K01056	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	Pept_tRNA_hydro
HKD2_k127_309912_0	1408422.JHYF01000012_gene3157	0.0	1125.0	COG1197@1|root,COG1197@2|Bacteria,1TPF1@1239|Firmicutes,248D8@186801|Clostridia,36F91@31979|Clostridiaceae	186801|Clostridia	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
HKD2_k127_3135174_0	767817.Desgi_1737	1.592e-206	647.0	COG0642@1|root,COG2205@2|Bacteria,1VS9T@1239|Firmicutes,24YTS@186801|Clostridia,267DP@186807|Peptococcaceae	186801|Clostridia	T	PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	2.7.13.3	ko:K18350	ko01502,ko02020,map01502,map02020	M00652,M00657	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko01504,ko02022	-	-	-	HAMP,HATPase_c,HisKA
HKD2_k127_3135174_3	767817.Desgi_1736	4.071e-145	461.0	COG0745@1|root,COG0745@2|Bacteria,1TP9M@1239|Firmicutes,247TK@186801|Clostridia,263HC@186807|Peptococcaceae	186801|Clostridia	K	PFAM Response regulator receiver domain	vanR	-	-	ko:K18349	ko01502,ko02020,map01502,map02020	M00652,M00657	-	-	ko00000,ko00001,ko00002,ko01504,ko02022	-	-	-	Response_reg,Trans_reg_C
HKD2_k127_3135174_2	1078085.HMPREF1210_01448	1.839e-173	547.0	COG2378@1|root,COG2378@2|Bacteria,1U8E4@1239|Firmicutes,4HD9M@91061|Bacilli,26G4K@186818|Planococcaceae	91061|Bacilli	K	WYL domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_11,WYL
HKD2_k127_3135174_11	935836.JAEL01000034_gene4438	5.498e-44	165.0	COG3708@1|root,COG3708@2|Bacteria,1V28Z@1239|Firmicutes,4HFQG@91061|Bacilli,1ZD3G@1386|Bacillus	91061|Bacilli	K	Integron-associated effector binding protein	-	-	-	-	-	-	-	-	-	-	-	-	Cass2
HKD2_k127_3135174_7	1461580.CCAS010000049_gene3556	4.327e-91	301.0	2C3KP@1|root,2Z802@2|Bacteria,1TQD1@1239|Firmicutes,4HBGA@91061|Bacilli,1ZC7G@1386|Bacillus	91061|Bacilli	S	Phage tail protein	yjhE	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3135174_5	1301100.HG529318_gene6132	2.472e-103	343.0	COG2207@1|root,COG2207@2|Bacteria,1UYFB@1239|Firmicutes,25BJG@186801|Clostridia,36WMU@31979|Clostridiaceae	186801|Clostridia	K	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	AraC_binding,Cupin_2,HTH_18
HKD2_k127_3135174_6	1347392.CCEZ01000043_gene41	7.162e-103	345.0	COG1171@1|root,COG1171@2|Bacteria,1TR70@1239|Firmicutes,2485T@186801|Clostridia,36DJQ@31979|Clostridiaceae	186801|Clostridia	E	Diaminopropionate ammonia-lyase	dpaL	-	4.3.1.15	ko:K01751	-	-	-	-	ko00000,ko01000	-	-	-	PALP
HKD2_k127_3135174_1	742733.HMPREF9469_01756	1.794e-179	568.0	COG0624@1|root,COG0624@2|Bacteria,1TR99@1239|Firmicutes,248DC@186801|Clostridia,21XU5@1506553|Lachnoclostridium	186801|Clostridia	E	Psort location Cytoplasmic, score 8.87	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
HKD2_k127_3135174_4	509191.AEDB02000108_gene1554	5.192e-140	449.0	COG0053@1|root,COG0053@2|Bacteria,1TSGY@1239|Firmicutes,2491V@186801|Clostridia,3WJUR@541000|Ruminococcaceae	186801|Clostridia	P	Dimerisation domain of Zinc Transporter	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,ZT_dimer
HKD2_k127_3135174_8	1487921.DP68_15730	3.181e-70	242.0	COG0662@1|root,COG0662@2|Bacteria,1V3H4@1239|Firmicutes,24HNT@186801|Clostridia,36EST@31979|Clostridiaceae	186801|Clostridia	G	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HKD2_k127_3135174_10	720554.Clocl_0707	4.433e-51	183.0	COG1633@1|root,COG1633@2|Bacteria,1V6KG@1239|Firmicutes,24KVG@186801|Clostridia,3WJE4@541000|Ruminococcaceae	186801|Clostridia	S	Ubiquinone biosynthesis protein COQ7	-	-	-	-	-	-	-	-	-	-	-	-	COQ7
HKD2_k127_3135174_9	485916.Dtox_0438	2.282e-59	207.0	COG1733@1|root,COG1733@2|Bacteria,1VA9M@1239|Firmicutes,24KBG@186801|Clostridia,265C8@186807|Peptococcaceae	186801|Clostridia	K	HxlR-like helix-turn-helix	hxlR	-	-	-	-	-	-	-	-	-	-	-	HxlR
HKD2_k127_3135174_12	509191.AEDB02000002_gene1159	2.497e-31	124.0	COG1182@1|root,COG1182@2|Bacteria,1UZBY@1239|Firmicutes,248VP@186801|Clostridia,3WSBX@541000|Ruminococcaceae	186801|Clostridia	C	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity	azoR	-	-	ko:K01118	-	-	-	-	ko00000,ko01000	-	-	-	Flavodoxin_2
HKD2_k127_3144303_1	484770.UFO1_0938	8.148e-38	143.0	COG2213@1|root,COG2213@2|Bacteria,1TPE3@1239|Firmicutes,4H313@909932|Negativicutes	909932|Negativicutes	G	PTS system mannitol-specific	-	-	2.7.1.197	ko:K02798,ko:K02799,ko:K02800	ko00051,ko02060,map00051,map02060	M00274	R02704	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.2.1.12,4.A.2.1.2,4.A.2.1.24,4.A.2.1.5	-	-	PTS_EIIC,PTS_IIB
HKD2_k127_3144303_0	293826.Amet_4270	8.694e-200	642.0	COG1762@1|root,COG3711@1|root,COG1762@2|Bacteria,COG3711@2|Bacteria,1TQT1@1239|Firmicutes,248PT@186801|Clostridia,36F0A@31979|Clostridiaceae	186801|Clostridia	GKT	phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2	-	-	-	ko:K03483	-	-	-	-	ko00000,ko03000	-	-	-	HTH_11,Mga,PRD,PTS_EIIA_2,PTS_IIB
HKD2_k127_3181124_0	1132442.KB889752_gene1475	2.958e-166	526.0	COG0574@1|root,COG3848@1|root,COG0574@2|Bacteria,COG3848@2|Bacteria,1UYA0@1239|Firmicutes,4HD4S@91061|Bacilli,1ZAW5@1386|Bacillus	91061|Bacilli	GT	phosphoenolpyruvate synthase	pps	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PPDK_N
HKD2_k127_3181124_5	293826.Amet_3778	3.286e-60	208.0	COG1225@1|root,COG1225@2|Bacteria,1VBNH@1239|Firmicutes,24QGI@186801|Clostridia	186801|Clostridia	O	Redoxin	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
HKD2_k127_3181124_7	293826.Amet_3778	2.369e-14	74.0	COG1225@1|root,COG1225@2|Bacteria,1VBNH@1239|Firmicutes,24QGI@186801|Clostridia	186801|Clostridia	O	Redoxin	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
HKD2_k127_3181124_4	1195236.CTER_1297	1.198e-114	375.0	COG0789@1|root,COG0789@2|Bacteria,1TQ78@1239|Firmicutes,247ZI@186801|Clostridia,3WGDC@541000|Ruminococcaceae	186801|Clostridia	K	helix_turn_helix, mercury resistance	-	-	-	-	-	-	-	-	-	-	-	-	MerR_1
HKD2_k127_3181124_1	1132442.KB889752_gene1436	4.343e-163	516.0	COG5184@1|root,COG5184@2|Bacteria,1UZD4@1239|Firmicutes,4HD48@91061|Bacilli,1ZESI@1386|Bacillus	91061|Bacilli	DZ	COG5184 Alpha-tubulin suppressor and related RCC1 domain-containing proteins	-	-	-	-	-	-	-	-	-	-	-	-	RCC1_2
HKD2_k127_3181124_3	1195236.CTER_1295	2.924e-125	404.0	2E4WJ@1|root,32ZQP@2|Bacteria,1VPIV@1239|Firmicutes,25H5V@186801|Clostridia,3WM3A@541000|Ruminococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3181124_2	318464.IO99_03550	9.445e-161	509.0	COG3910@1|root,COG3910@2|Bacteria,1TSWP@1239|Firmicutes,249W3@186801|Clostridia,36DQM@31979|Clostridiaceae	186801|Clostridia	S	AAA ATPase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_15,AAA_21
HKD2_k127_3181124_6	138119.DSY3068	6.541e-52	184.0	COG0644@1|root,COG0644@2|Bacteria,1UZT1@1239|Firmicutes,25DJ8@186801|Clostridia	186801|Clostridia	C	oxidoreductase	cbrA	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3,Lycopene_cycl,NAD_binding_8
HKD2_k127_3233599_1	536232.CLM_2236	3.382e-130	427.0	COG3875@1|root,COG3875@2|Bacteria,1TQ1C@1239|Firmicutes,247PH@186801|Clostridia,36DMW@31979|Clostridiaceae	186801|Clostridia	S	Domain of unknown function (DUF2088)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2088
HKD2_k127_3233599_2	445335.CBN_2083	3.659e-92	309.0	COG0834@1|root,COG0834@2|Bacteria,1TT16@1239|Firmicutes,24CEZ@186801|Clostridia,36EZP@31979|Clostridiaceae	186801|Clostridia	ET	Belongs to the bacterial solute-binding protein 3 family	artP	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	SBP_bac_3
HKD2_k127_3233599_0	545243.BAEV01000003_gene3353	1.524e-151	488.0	COG0436@1|root,COG0436@2|Bacteria,1TP0J@1239|Firmicutes,247NQ@186801|Clostridia,36DUZ@31979|Clostridiaceae	186801|Clostridia	E	Aminotransferase	aspC	-	-	ko:K10907	-	-	-	-	ko00000,ko01000,ko01007	-	-	-	Aminotran_1_2
HKD2_k127_3233599_3	1122947.FR7_3355	2.725e-57	202.0	COG3344@1|root,COG3344@2|Bacteria,1TP9A@1239|Firmicutes,4H2U6@909932|Negativicutes	909932|Negativicutes	L	PFAM RNA-directed DNA polymerase (Reverse transcriptase)	-	-	-	-	-	-	-	-	-	-	-	-	GIIM,RVT_1
HKD2_k127_3271954_5	1151292.QEW_4151	4.316e-30	123.0	COG2195@1|root,COG2195@2|Bacteria,1TP3A@1239|Firmicutes,248JJ@186801|Clostridia,25SM0@186804|Peptostreptococcaceae	186801|Clostridia	E	Peptidase family M28	-	-	3.4.11.4	ko:K01258	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
HKD2_k127_3271954_4	573061.Clocel_2686	2.671e-42	161.0	COG1670@1|root,COG1670@2|Bacteria,1V1G8@1239|Firmicutes,24G73@186801|Clostridia,36I5H@31979|Clostridiaceae	186801|Clostridia	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
HKD2_k127_3271954_6	1540257.JQMW01000013_gene1303	6.931e-16	85.0	COG1670@1|root,COG1670@2|Bacteria,1V1G8@1239|Firmicutes,24G73@186801|Clostridia,36I5H@31979|Clostridiaceae	186801|Clostridia	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
HKD2_k127_3271954_3	857293.CAAU_0955	7.411e-48	181.0	2F6WH@1|root,33ZCJ@2|Bacteria,1VWVE@1239|Firmicutes,251WV@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3271954_2	994573.T472_0201925	4.724e-79	278.0	COG0477@1|root,COG2814@2|Bacteria,1TS3C@1239|Firmicutes,25F93@186801|Clostridia	186801|Clostridia	EGP	Nucleoside H+ symporter	-	-	-	ko:K05820	-	-	-	-	ko00000,ko02000	2.A.1.27	-	-	MFS_1_like
HKD2_k127_3271954_0	1408422.JHYF01000002_gene2267	2.981e-238	746.0	COG1866@1|root,COG1866@2|Bacteria,1TPQV@1239|Firmicutes,248JE@186801|Clostridia,36DFD@31979|Clostridiaceae	186801|Clostridia	H	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA	pckA	-	4.1.1.49	ko:K01610	ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200	M00003,M00170	R00341	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPCK_ATP
HKD2_k127_3271954_1	1345695.CLSA_c25730	1.546e-96	331.0	COG5002@1|root,COG5002@2|Bacteria,1VRP7@1239|Firmicutes,24YHW@186801|Clostridia,36UJK@31979|Clostridiaceae	186801|Clostridia	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,MASE3,PAS,PAS_8,PAS_9
HKD2_k127_3356_1	1128398.Curi_c23050	7.746e-59	208.0	COG5523@1|root,COG5523@2|Bacteria,1V6FC@1239|Firmicutes,24JPX@186801|Clostridia,26B19@186813|unclassified Clostridiales	186801|Clostridia	S	Protein of unknown function (DUF975)	-	-	-	-	-	-	-	-	-	-	-	-	DUF975
HKD2_k127_3356_3	1304284.L21TH_1040	7.976e-05	50.0	2DR9X@1|root,33AUW@2|Bacteria,1VKEA@1239|Firmicutes,25EBJ@186801|Clostridia,36PFS@31979|Clostridiaceae	186801|Clostridia	S	PrcB C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	PrcB_C
HKD2_k127_3356_2	665942.HMPREF1022_02660	4.21e-10	66.0	28J3M@1|root,2Z8ZT@2|Bacteria,1Q2A4@1224|Proteobacteria,42YAU@68525|delta/epsilon subdivisions,2WUHX@28221|Deltaproteobacteria,2MEH6@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	HNH nucleases	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3356_0	44251.PDUR_14655	5.91e-100	336.0	COG0642@1|root,COG2205@2|Bacteria,1V10X@1239|Firmicutes,4HB4P@91061|Bacilli,26SCI@186822|Paenibacillaceae	91061|Bacilli	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
HKD2_k127_3377958_7	794903.OPIT5_18555	2.355e-41	162.0	COG0400@1|root,COG0400@2|Bacteria,46VTC@74201|Verrucomicrobia	74201|Verrucomicrobia	S	carboxylic ester hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3377958_2	1304284.L21TH_1742	2.132e-112	377.0	COG0642@1|root,COG2205@2|Bacteria,1UYC9@1239|Firmicutes,24CPQ@186801|Clostridia,36GIS@31979|Clostridiaceae	186801|Clostridia	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
HKD2_k127_3377958_3	1304284.L21TH_1743	2.692e-101	334.0	COG0745@1|root,COG0745@2|Bacteria,1TR8K@1239|Firmicutes,24DTS@186801|Clostridia,36FP8@31979|Clostridiaceae	186801|Clostridia	K	response regulator, receiver	cssR	-	-	ko:K07770	ko02020,map02020	M00448	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
HKD2_k127_3377958_8	1286171.EAL2_c08560	1.334e-40	156.0	COG0681@1|root,COG0681@2|Bacteria,1V7H9@1239|Firmicutes,24MVR@186801|Clostridia,25WYS@186806|Eubacteriaceae	186801|Clostridia	U	Belongs to the peptidase S26 family	lepB	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24
HKD2_k127_3377958_6	1284352.AOIG01000008_gene2434	2.404e-43	164.0	COG2306@1|root,COG2306@2|Bacteria,1VARK@1239|Firmicutes,4HHJ8@91061|Bacilli,26S4W@186822|Paenibacillaceae	91061|Bacilli	S	Protein of unknown function (DUF402)	-	-	-	ko:K09145	-	-	-	-	ko00000	-	-	-	DUF402
HKD2_k127_3377958_4	536227.CcarbDRAFT_4625	3.737e-92	311.0	COG0384@1|root,COG0384@2|Bacteria,1TSV5@1239|Firmicutes,25D2E@186801|Clostridia,36U60@31979|Clostridiaceae	186801|Clostridia	S	Phenazine biosynthesis-like protein	-	-	-	-	-	-	-	-	-	-	-	-	PhzC-PhzF
HKD2_k127_3377958_9	913865.DOT_4912	3.822e-26	113.0	COG4767@1|root,COG4767@2|Bacteria,1UW2Z@1239|Firmicutes,25MMT@186801|Clostridia,265PI@186807|Peptococcaceae	186801|Clostridia	V	VanZ like family	-	-	-	-	-	-	-	-	-	-	-	-	VanZ
HKD2_k127_3377958_10	318464.IO99_07195	2.274e-25	109.0	COG3153@1|root,COG3153@2|Bacteria,1VZZ4@1239|Firmicutes,24RJR@186801|Clostridia,36RSA@31979|Clostridiaceae	186801|Clostridia	S	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3377958_1	293826.Amet_4567	3.04e-215	683.0	COG1001@1|root,COG1001@2|Bacteria,1TP84@1239|Firmicutes,247KN@186801|Clostridia,36DDA@31979|Clostridiaceae	186801|Clostridia	F	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family	ade	-	3.5.4.2	ko:K01486	ko00230,ko01100,map00230,map01100	-	R01244	RC00477	ko00000,ko00001,ko01000	-	-	-	Adenine_deam_C,Amidohydro_1
HKD2_k127_3377958_0	857293.CAAU_2228	8.666e-230	720.0	COG1190@1|root,COG1190@2|Bacteria,1TP2P@1239|Firmicutes,247VX@186801|Clostridia,36DX4@31979|Clostridiaceae	186801|Clostridia	J	Belongs to the class-II aminoacyl-tRNA synthetase family	lysS	-	6.1.1.6	ko:K04567	ko00970,map00970	M00359,M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon,tRNA_bind
HKD2_k127_3377958_5	203119.Cthe_2897	4.73e-59	209.0	COG0782@1|root,COG0782@2|Bacteria,1V44S@1239|Firmicutes,24HP9@186801|Clostridia,3WIJW@541000|Ruminococcaceae	186801|Clostridia	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides	greA	-	-	ko:K03624	-	-	-	-	ko00000,ko03021	-	-	-	GreA_GreB,GreA_GreB_N
HKD2_k127_337896_2	1294142.CINTURNW_3018	3.652e-31	130.0	COG0551@1|root,COG1787@1|root,COG0551@2|Bacteria,COG1787@2|Bacteria,1VBYF@1239|Firmicutes,24R49@186801|Clostridia,36MS5@31979|Clostridiaceae	186801|Clostridia	V	Restriction endonuclease	-	-	-	ko:K07448	-	-	-	-	ko00000,ko02048	-	-	-	Ftsk_gamma,Mrr_cat,zf-C4_Topoisom
HKD2_k127_337896_0	1230342.CTM_07156	2.145e-186	590.0	COG3633@1|root,COG3633@2|Bacteria,1TPD2@1239|Firmicutes,25CGY@186801|Clostridia,36FK4@31979|Clostridiaceae	186801|Clostridia	E	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)	sstT	-	-	ko:K07862	-	-	-	-	ko00000,ko02000	2.A.23.4	-	-	SDF
HKD2_k127_337896_1	536233.CLO_1481	2.787e-56	208.0	COG0628@1|root,COG0628@2|Bacteria,1TQ84@1239|Firmicutes,2492D@186801|Clostridia,36DCR@31979|Clostridiaceae	186801|Clostridia	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
HKD2_k127_3396952_5	398512.JQKC01000007_gene1216	1.704e-79	269.0	COG1530@1|root,COG1530@2|Bacteria,1TQS4@1239|Firmicutes,247QV@186801|Clostridia,3WICU@541000|Ruminococcaceae	186801|Clostridia	J	TIGRFAM ribonuclease, Rne Rng family	rng	-	-	ko:K08301	-	-	-	-	ko00000,ko01000,ko03009,ko03019	-	-	-	RNase_E_G,S1,TRAM
HKD2_k127_3396952_12	1485543.JMME01000012_gene54	2.145e-38	146.0	COG0261@1|root,COG0261@2|Bacteria,1V9YH@1239|Firmicutes,4H4VN@909932|Negativicutes	909932|Negativicutes	J	This protein binds to 23S rRNA in the presence of protein L20	rplU	-	-	ko:K02888	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L21p
HKD2_k127_3396952_16	293826.Amet_2304	1.9e-23	103.0	COG2868@1|root,COG2868@2|Bacteria,1VCNG@1239|Firmicutes,24R3H@186801|Clostridia,36MS0@31979|Clostridiaceae	186801|Clostridia	J	Cysteine protease Prp	-	-	-	ko:K07584	-	-	-	-	ko00000	-	-	-	Peptidase_Prp
HKD2_k127_3396952_11	1304880.JAGB01000002_gene2060	3.171e-46	167.0	COG0211@1|root,COG0211@2|Bacteria,1V6HW@1239|Firmicutes,24N3D@186801|Clostridia	186801|Clostridia	J	Belongs to the bacterial ribosomal protein bL27 family	rpmA	-	-	ko:K02899	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27
HKD2_k127_3396952_1	293826.Amet_2307	3.67e-166	532.0	COG0536@1|root,COG0536@2|Bacteria,1TPX7@1239|Firmicutes,247SP@186801|Clostridia,36DEA@31979|Clostridiaceae	186801|Clostridia	S	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control	obg	-	-	ko:K03979	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	DUF1967,GTP1_OBG,MMR_HSR1
HKD2_k127_3396952_17	1304284.L21TH_2115	7.902e-19	87.0	2EPI7@1|root,33H4V@2|Bacteria,1VQG8@1239|Firmicutes,24UY1@186801|Clostridia,36NBV@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3396952_15	1304284.L21TH_2114	8.758e-29	118.0	COG1534@1|root,COG1534@2|Bacteria,1VEGM@1239|Firmicutes,24QZB@186801|Clostridia,36KS2@31979|Clostridiaceae	186801|Clostridia	J	RNA-binding protein	yhbY	-	-	ko:K07574	-	-	-	-	ko00000,ko03009	-	-	-	CRS1_YhbY
HKD2_k127_3396952_7	697303.Thewi_1007	1.877e-71	247.0	COG1057@1|root,COG1057@2|Bacteria,1V3SK@1239|Firmicutes,24JFM@186801|Clostridia,42EM4@68295|Thermoanaerobacterales	186801|Clostridia	H	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)	nadD	-	2.7.7.18	ko:K00969	ko00760,ko01100,map00760,map01100	M00115	R00137,R03005	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
HKD2_k127_3396952_10	910314.HMPREF9220_0965	3.158e-48	179.0	COG1713@1|root,COG1713@2|Bacteria,1V6Y1@1239|Firmicutes,4H526@909932|Negativicutes	909932|Negativicutes	H	Hydrolase, HD family	-	-	-	-	-	-	-	-	-	-	-	-	HD
HKD2_k127_3396952_8	935948.KE386494_gene338	5.762e-68	246.0	COG1316@1|root,COG1316@2|Bacteria,1TR1B@1239|Firmicutes,24AAY@186801|Clostridia,42F9G@68295|Thermoanaerobacterales	186801|Clostridia	K	TIGRFAM cell envelope-related function transcriptional attenuator, LytR CpsA family	lytR	-	-	-	-	-	-	-	-	-	-	-	LytR_C,LytR_cpsA_psr
HKD2_k127_3396952_13	203119.Cthe_1238	6.528e-35	138.0	COG0799@1|root,COG0799@2|Bacteria,1VA2Z@1239|Firmicutes,24MVA@186801|Clostridia,3WJVU@541000|Ruminococcaceae	186801|Clostridia	J	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation	rsfS	-	-	ko:K09710	-	-	-	-	ko00000,ko03009	-	-	-	RsfS
HKD2_k127_3396952_6	1408422.JHYF01000001_gene2654	8.059e-72	248.0	COG2964@1|root,COG2964@2|Bacteria,1TSI2@1239|Firmicutes,249X6@186801|Clostridia,36VXR@31979|Clostridiaceae	186801|Clostridia	S	HTH domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_22,PAS_6
HKD2_k127_3396952_9	1392493.JIAB01000001_gene2060	1.608e-48	176.0	COG0251@1|root,COG0251@2|Bacteria,1V6HG@1239|Firmicutes,24J8Y@186801|Clostridia,27N9W@186928|unclassified Lachnospiraceae	186801|Clostridia	J	Endoribonuclease L-PSP	-	-	3.5.99.10	ko:K09022	-	-	R11098,R11099	RC03275,RC03354	ko00000,ko01000	-	-	-	Ribonuc_L-PSP
HKD2_k127_3396952_4	580331.Thit_0864	2.263e-95	327.0	COG1686@1|root,COG1686@2|Bacteria,1TQ8M@1239|Firmicutes,2480S@186801|Clostridia,42F4N@68295|Thermoanaerobacterales	186801|Clostridia	M	PFAM peptidase S11, D-alanyl-D-alanine carboxypeptidase	-	-	3.4.16.4	ko:K07258	ko00550,ko01100,map00550,map01100	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	PBP5_C,Peptidase_S11
HKD2_k127_3396952_14	580331.Thit_0865	3.431e-32	133.0	COG1555@1|root,COG1596@1|root,COG1555@2|Bacteria,COG1596@2|Bacteria,1VA3W@1239|Firmicutes,24MQF@186801|Clostridia,42GSI@68295|Thermoanaerobacterales	186801|Clostridia	LM	Helix-hairpin-helix motif	comEA	-	-	ko:K02237	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	HHH_3,SLBB
HKD2_k127_3396952_2	756499.Desde_1009	2.25e-138	446.0	COG0709@1|root,COG0709@2|Bacteria,1TQCJ@1239|Firmicutes,247NS@186801|Clostridia,260DU@186807|Peptococcaceae	186801|Clostridia	F	Synthesizes selenophosphate from selenide and ATP	selD	-	2.7.9.3	ko:K01008	ko00450,ko01100,map00450,map01100	-	R03595	RC00002,RC02878	ko00000,ko00001,ko01000,ko03016	-	-	-	AIRS,AIRS_C
HKD2_k127_3396952_0	1408422.JHYF01000001_gene2675	4.868e-168	541.0	COG1921@1|root,COG1921@2|Bacteria,1TQT8@1239|Firmicutes,2498U@186801|Clostridia,36DPP@31979|Clostridiaceae	186801|Clostridia	J	Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis	selA	-	2.9.1.1	ko:K01042	ko00450,ko00970,map00450,map00970	-	R08219	RC01246	ko00000,ko00001,ko01000	-	-	-	Se-cys_synth_N,SelA
HKD2_k127_3396952_3	748727.CLJU_c27700	2.391e-134	434.0	COG3276@1|root,COG3276@2|Bacteria,1TPQS@1239|Firmicutes,2484U@186801|Clostridia,36E0X@31979|Clostridiaceae	186801|Clostridia	J	translation elongation factor	selB	-	-	ko:K03833	-	-	-	-	ko00000,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,SelB-wing_2,SelB-wing_3
HKD2_k127_3415202_1	1280668.ATVT01000011_gene3303	6.761e-197	625.0	COG1129@1|root,COG1129@2|Bacteria,1TP6I@1239|Firmicutes,247II@186801|Clostridia,4BXM3@830|Butyrivibrio	186801|Clostridia	G	ATPases associated with a variety of cellular activities	-	-	3.6.3.17	ko:K10441	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	ABC_tran
HKD2_k127_3415202_0	994573.T472_0201725	9.665e-274	851.0	COG1472@1|root,COG1472@2|Bacteria,1TP63@1239|Firmicutes,24YIP@186801|Clostridia,36W7H@31979|Clostridiaceae	186801|Clostridia	G	hydrolase, family 3	-	-	3.2.1.52	ko:K01207	ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501	M00628	R00022,R05963,R07809,R07810,R10831	RC00049	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyco_hydro_3
HKD2_k127_3415202_2	1294142.CINTURNW_3366	8.133e-133	435.0	COG2207@1|root,COG2207@2|Bacteria,1V28B@1239|Firmicutes,25C1T@186801|Clostridia,36WMQ@31979|Clostridiaceae	186801|Clostridia	K	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18
HKD2_k127_3464840_20	857293.CAAU_0338	1.406e-18	85.0	COG4214@1|root,COG4214@2|Bacteria,1VU1F@1239|Firmicutes,24XS9@186801|Clostridia,36UQN@31979|Clostridiaceae	186801|Clostridia	G	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K10547	ko02010,map02010	M00216	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.5	-	-	BPD_transp_2
HKD2_k127_3464840_21	293826.Amet_2468	3.467e-13	74.0	2DXGC@1|root,344WJ@2|Bacteria,1VYV1@1239|Firmicutes,24THN@186801|Clostridia,36P3E@31979|Clostridiaceae	186801|Clostridia	S	Lysine exporter LysO	-	-	-	-	-	-	-	-	-	-	-	-	Lys_export
HKD2_k127_3464840_7	1408422.JHYF01000001_gene2778	2.713e-74	254.0	COG2431@1|root,COG2431@2|Bacteria,1V44M@1239|Firmicutes,24I3B@186801|Clostridia,36ID9@31979|Clostridiaceae	186801|Clostridia	S	Lysine exporter LysO	-	-	-	-	-	-	-	-	-	-	-	-	Lys_export
HKD2_k127_3464840_19	1304880.JAGB01000001_gene883	2.613e-28	121.0	COG0454@1|root,COG0456@2|Bacteria,1VNCK@1239|Firmicutes,24Q01@186801|Clostridia	186801|Clostridia	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_4
HKD2_k127_3464840_14	1160707.AJIK01000011_gene2578	2.553e-47	176.0	COG0741@1|root,COG0741@2|Bacteria,1V6DD@1239|Firmicutes,4HIWA@91061|Bacilli,26FJU@186818|Planococcaceae	91061|Bacilli	M	Transglycosylase SLT domain	yjbJ	-	-	-	-	-	-	-	-	-	-	-	SLT
HKD2_k127_3464840_17	1304284.L21TH_2149	3.394e-39	149.0	COG4109@1|root,COG4109@2|Bacteria,1VA3T@1239|Firmicutes,24MQM@186801|Clostridia,36KUH@31979|Clostridiaceae	186801|Clostridia	K	DRTGG domain	-	-	-	-	-	-	-	-	-	-	-	-	DRTGG
HKD2_k127_3464840_15	1408422.JHYF01000001_gene2897	6.509e-47	172.0	COG2172@1|root,COG2172@2|Bacteria,1V6YP@1239|Firmicutes,24JJ0@186801|Clostridia,36JQQ@31979|Clostridiaceae	186801|Clostridia	T	Histidine kinase-like ATPase domain	RsbW	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HATPase_c_2
HKD2_k127_3464840_2	273068.TTE0887	8.877e-137	448.0	COG2000@1|root,COG2221@1|root,COG4624@1|root,COG2000@2|Bacteria,COG2221@2|Bacteria,COG4624@2|Bacteria,1TRB4@1239|Firmicutes,24BF5@186801|Clostridia,42F1E@68295|Thermoanaerobacterales	186801|Clostridia	C	Fe-S cluster domain protein	-	-	-	-	-	-	-	-	-	-	-	-	FeS,Fe_hyd_lg_C,Fer4,Fer4_10,Fer4_9
HKD2_k127_3464840_18	1031288.AXAA01000004_gene1812	1.792e-34	134.0	COG0857@1|root,COG0857@2|Bacteria,1VEWN@1239|Firmicutes,24QW9@186801|Clostridia,36MIJ@31979|Clostridiaceae	186801|Clostridia	C	DRTGG domain	-	-	-	-	-	-	-	-	-	-	-	-	DRTGG
HKD2_k127_3464840_8	203119.Cthe_0337	2.284e-72	251.0	COG0613@1|root,COG0613@2|Bacteria,1V3ZK@1239|Firmicutes,24HHA@186801|Clostridia,3WJP0@541000|Ruminococcaceae	186801|Clostridia	S	PHP domain	-	-	3.1.3.97	ko:K07053	-	-	R00188,R11188	RC00078	ko00000,ko01000	-	-	-	PHP
HKD2_k127_3464840_9	697281.Mahau_1250	6.848e-61	213.0	COG1905@1|root,COG1905@2|Bacteria,1V737@1239|Firmicutes,24HFB@186801|Clostridia,42G6R@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit	nuoE	-	1.12.1.3,1.17.1.11,1.6.5.3	ko:K00334,ko:K18330,ko:K22340	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
HKD2_k127_3464840_10	748449.Halha_2288	6.018e-56	200.0	COG3290@1|root,COG3290@2|Bacteria,1UJ85@1239|Firmicutes,25EY1@186801|Clostridia,3WBTR@53433|Halanaerobiales	186801|Clostridia	T	PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c
HKD2_k127_3464840_13	857293.CAAU_0206	1.334e-50	182.0	COG3411@1|root,COG3411@2|Bacteria,1V6DT@1239|Firmicutes,24M31@186801|Clostridia,36JIG@31979|Clostridiaceae	186801|Clostridia	C	Ferredoxin	-	-	1.12.1.3	ko:K17992	-	-	-	-	ko00000,ko01000	-	-	-	2Fe-2S_thioredx
HKD2_k127_3464840_0	720554.Clocl_1312	1.385e-313	968.0	COG1894@1|root,COG1894@2|Bacteria,1TQB0@1239|Firmicutes,2483E@186801|Clostridia,3WGG2@541000|Ruminococcaceae	186801|Clostridia	C	NADH ubiquinone oxidoreductase	hymB	-	1.12.1.3,1.17.1.11,1.6.5.3	ko:K00335,ko:K18331,ko:K22339	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx,Complex1_51K,Fer4,NADH_4Fe-4S,SLBB
HKD2_k127_3464840_11	1121091.AUMP01000002_gene2222	3.5e-54	195.0	2CJF8@1|root,32S9W@2|Bacteria,1VAH7@1239|Firmicutes	1239|Firmicutes	S	Protein of unknown function (DUF3189)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3189
HKD2_k127_3464840_1	1304284.L21TH_2143	9.267e-195	616.0	COG4656@1|root,COG4656@2|Bacteria,1TPCC@1239|Firmicutes,24805@186801|Clostridia,36F8C@31979|Clostridiaceae	186801|Clostridia	C	Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily	rnfC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03615	-	-	-	-	ko00000	-	-	-	Complex1_51K,Fer4,Fer4_10,Fer4_7,Fer4_9,RnfC_N,SLBB
HKD2_k127_3464840_4	1511.CLOST_1401	1.613e-126	411.0	COG4658@1|root,COG4658@2|Bacteria,1TQAY@1239|Firmicutes,247TM@186801|Clostridia,25SDW@186804|Peptostreptococcaceae	186801|Clostridia	C	NQR2, RnfD, RnfE family	rnfD	-	-	ko:K03614	-	-	-	-	ko00000	-	-	-	NQR2_RnfD_RnfE
HKD2_k127_3464840_16	697281.Mahau_1155	5.542e-41	158.0	COG4659@1|root,COG4659@2|Bacteria,1V7R1@1239|Firmicutes,24JVM@186801|Clostridia,42GX0@68295|Thermoanaerobacterales	186801|Clostridia	P	Part of a membrane complex involved in electron transport	rnfG	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03612	-	-	-	-	ko00000	-	-	-	FMN_bind
HKD2_k127_3464840_6	509191.AEDB02000035_gene2134	7.096e-77	262.0	COG4660@1|root,COG4660@2|Bacteria,1TSE7@1239|Firmicutes,24972@186801|Clostridia,3WHAI@541000|Ruminococcaceae	186801|Clostridia	C	Part of a membrane complex involved in electron transport	rnfE	-	-	ko:K03613	-	-	-	-	ko00000	-	-	-	Rnf-Nqr
HKD2_k127_3464840_5	1511.CLOST_1398	4.857e-81	274.0	COG4657@1|root,COG4657@2|Bacteria,1TS06@1239|Firmicutes,247UE@186801|Clostridia,25T7Q@186804|Peptostreptococcaceae	186801|Clostridia	U	Part of a membrane complex involved in electron transport	rnfA	-	-	ko:K03617	-	-	-	-	ko00000	-	-	-	Rnf-Nqr
HKD2_k127_3464840_3	1304284.L21TH_2138	3.689e-134	434.0	COG1142@1|root,COG2878@1|root,COG1142@2|Bacteria,COG2878@2|Bacteria,1TQGD@1239|Firmicutes,24904@186801|Clostridia,36FC4@31979|Clostridiaceae	186801|Clostridia	C	electron transport complex, RnfABCDGE type, B subunit	rnfB	-	-	ko:K03616	-	-	-	-	ko00000	-	-	-	FeS,Fer4,Fer4_13,Fer4_4,Fer4_9
HKD2_k127_3464840_22	1232452.BAIB02000006_gene1174	4.153e-09	61.0	2C5I7@1|root,330HE@2|Bacteria,1VJU8@1239|Firmicutes,24SCX@186801|Clostridia,26BR2@186813|unclassified Clostridiales	186801|Clostridia	S	Domain of unknown function (DUF4321)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4321
HKD2_k127_3464840_12	941824.TCEL_00174	1.621e-53	195.0	COG0424@1|root,COG0424@2|Bacteria,1V6FH@1239|Firmicutes,24JRN@186801|Clostridia,36IU5@31979|Clostridiaceae	186801|Clostridia	D	Maf-like protein	maf	-	-	ko:K06287	-	-	-	-	ko00000	-	-	-	Maf
HKD2_k127_3464840_23	445335.CBN_3046	6.789e-07	51.0	COG2003@1|root,COG2003@2|Bacteria,1TQ3K@1239|Firmicutes,2498Z@186801|Clostridia,36DKZ@31979|Clostridiaceae	186801|Clostridia	E	Belongs to the UPF0758 family	radC	-	-	ko:K03630	-	-	-	-	ko00000	-	-	-	RadC
HKD2_k127_3505146_1	1122918.KB907245_gene5181	8.286e-80	270.0	COG0500@1|root,COG2226@2|Bacteria,1TSAZ@1239|Firmicutes,4HFFF@91061|Bacilli,26WG4@186822|Paenibacillaceae	91061|Bacilli	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
HKD2_k127_3505146_3	509191.AEDB02000081_gene2499	4.253e-65	226.0	COG1247@1|root,COG1247@2|Bacteria,1V6X5@1239|Firmicutes,24IB5@186801|Clostridia,3WM7D@541000|Ruminococcaceae	186801|Clostridia	M	Acetyltransferase (GNAT) domain	yncA	-	2.3.1.183	ko:K03823	ko00440,ko01130,map00440,map01130	-	R08871,R08938	RC00004,RC00064	ko00000,ko00001,ko01000	-	-	-	Acetyltransf_4
HKD2_k127_3505146_4	913865.DOT_5386	1.025e-63	228.0	COG1434@1|root,COG1434@2|Bacteria,1VA42@1239|Firmicutes,24HKK@186801|Clostridia	186801|Clostridia	O	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	DUF218
HKD2_k127_3505146_2	1347392.CCEZ01000049_gene1451	9.326e-70	243.0	2CYTA@1|root,32T4T@2|Bacteria,1VCWS@1239|Firmicutes,24JBX@186801|Clostridia,36H2Y@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Zn_dep_PLPC
HKD2_k127_3505146_0	768710.DesyoDRAFT_3332	1.157e-96	320.0	COG4832@1|root,COG4832@2|Bacteria,1TQC2@1239|Firmicutes,248YH@186801|Clostridia,264ZM@186807|Peptococcaceae	186801|Clostridia	S	conserved protein (DUF2174)	-	-	-	-	-	-	-	-	-	-	-	-	GyrI-like
HKD2_k127_3505146_5	290402.Cbei_3437	7.794e-50	180.0	COG0346@1|root,COG0346@2|Bacteria,1V4NM@1239|Firmicutes,24HFS@186801|Clostridia,36JBW@31979|Clostridiaceae	186801|Clostridia	E	PFAM Glyoxalase bleomycin resistance protein dioxygenase	-	-	4.4.1.5	ko:K01759	ko00620,map00620	-	R02530	RC00004,RC00740	ko00000,ko00001,ko01000	-	-	-	Glyoxalase,Glyoxalase_4
HKD2_k127_3505146_6	1408422.JHYF01000004_gene1654	2.972e-08	57.0	COG0312@1|root,COG0312@2|Bacteria,1TSQC@1239|Firmicutes,248MD@186801|Clostridia,36F5C@31979|Clostridiaceae	186801|Clostridia	S	modulator of DNA gyrase	-	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
HKD2_k127_360247_9	536227.CcarbDRAFT_1771	1.372e-118	388.0	COG4948@1|root,COG4948@2|Bacteria,1TQMS@1239|Firmicutes,25DGF@186801|Clostridia,36FGS@31979|Clostridiaceae	186801|Clostridia	M	mandelate racemase muconate lactonizing	-	-	5.1.1.20	ko:K19802	-	-	R10938	RC03309	ko00000,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
HKD2_k127_360247_12	1121289.JHVL01000033_gene2678	4.041e-70	246.0	COG0791@1|root,COG2367@1|root,COG0791@2|Bacteria,COG2367@2|Bacteria,1V1BR@1239|Firmicutes,24FVN@186801|Clostridia,36IIK@31979|Clostridiaceae	186801|Clostridia	M	NlpC/P60 family	-	-	3.5.2.6	ko:K17836	ko00311,ko01130,ko01501,map00311,map01130,map01501	M00627,M00628	R06363	RC01499	ko00000,ko00001,ko00002,ko01000,ko01504	-	-	-	NLPC_P60,SH3_3
HKD2_k127_360247_15	293826.Amet_4215	2.697e-57	210.0	COG2362@1|root,COG2362@2|Bacteria,1TSUZ@1239|Firmicutes,24CY1@186801|Clostridia,36EZF@31979|Clostridiaceae	186801|Clostridia	E	D-aminopeptidase	-	-	-	ko:K16203	-	-	-	-	ko00000,ko01000,ko01002	3.A.1.5.2	-	-	Peptidase_M55
HKD2_k127_360247_6	340099.Teth39_1689	8.371e-161	524.0	COG4166@1|root,COG4166@2|Bacteria,1TNYQ@1239|Firmicutes,25E4B@186801|Clostridia,42FZA@68295|Thermoanaerobacterales	186801|Clostridia	E	PFAM extracellular solute-binding protein, family 5	-	-	-	ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	SBP_bac_5
HKD2_k127_360247_11	1122947.FR7_2421	4.047e-80	283.0	COG0642@1|root,COG2205@2|Bacteria,1UITD@1239|Firmicutes,4H2C9@909932|Negativicutes	909932|Negativicutes	T	PFAM ATP-binding region, ATPase domain protein	-	-	2.7.13.3	ko:K07717	ko02020,map02020	M00518	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c
HKD2_k127_360247_13	273068.TTE1203	4.866e-68	241.0	COG4753@1|root,COG4753@2|Bacteria,1TPFP@1239|Firmicutes,24AIA@186801|Clostridia,42GP8@68295|Thermoanaerobacterales	186801|Clostridia	T	YcbB domain	-	-	-	ko:K07719	ko02020,map02020	M00518	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,YcbB
HKD2_k127_360247_10	869209.Tresu_1021	2.083e-102	342.0	COG2358@1|root,COG2358@2|Bacteria,2J705@203691|Spirochaetes	203691|Spirochaetes	S	TIGRFAM TRAP transporter solute receptor, TAXI family	-	-	-	ko:K07080	-	-	-	-	ko00000	-	-	-	NMT1_3
HKD2_k127_360247_16	877418.ATWV01000011_gene9	6.385e-15	81.0	COG4729@1|root,COG4729@2|Bacteria,2J86I@203691|Spirochaetes	203691|Spirochaetes	S	Domain of unknown function (DUF1850)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1850
HKD2_k127_360247_0	401526.TcarDRAFT_1522	3.213e-253	796.0	COG4666@1|root,COG4666@2|Bacteria,1TP0V@1239|Firmicutes,4H3FG@909932|Negativicutes	909932|Negativicutes	S	TRAP transporter, 4TM 12TM fusion protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF3394,DctM
HKD2_k127_360247_3	1121324.CLIT_4c01670	2.651e-213	672.0	COG1653@1|root,COG1653@2|Bacteria,1TQFZ@1239|Firmicutes,24MVM@186801|Clostridia	186801|Clostridia	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1,SBP_bac_8
HKD2_k127_360247_2	1121324.CLIT_4c01660	7.278e-223	704.0	COG2972@1|root,COG2972@2|Bacteria,1TPVR@1239|Firmicutes,247XB@186801|Clostridia,25RR9@186804|Peptostreptococcaceae	186801|Clostridia	T	Histidine kinase	-	-	2.7.13.3	ko:K07718	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,His_kinase,dCache_1
HKD2_k127_360247_5	1121324.CLIT_4c01650	1.689e-166	539.0	COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1TQCS@1239|Firmicutes,248SC@186801|Clostridia	186801|Clostridia	T	response regulator receiver	-	-	-	ko:K07720	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_18,HTH_AraC,Response_reg
HKD2_k127_360247_1	1121324.CLIT_4c01620	2.704e-248	773.0	COG1129@1|root,COG1129@2|Bacteria,1TP6I@1239|Firmicutes,247II@186801|Clostridia,25SPP@186804|Peptostreptococcaceae	186801|Clostridia	G	ATPases associated with a variety of cellular activities	-	-	-	ko:K17215	ko02010,map02010	M00593	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2	-	-	ABC_tran
HKD2_k127_360247_7	1121324.CLIT_4c01610	4.571e-157	500.0	COG1172@1|root,COG1172@2|Bacteria,1TP72@1239|Firmicutes,249FA@186801|Clostridia,25QDR@186804|Peptostreptococcaceae	186801|Clostridia	U	Belongs to the binding-protein-dependent transport system permease family	rbsC	-	-	ko:K10440,ko:K17214	ko02010,map02010	M00212,M00593	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2,3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	BPD_transp_2
HKD2_k127_360247_8	865861.AZSU01000002_gene2772	3.959e-156	498.0	COG1879@1|root,COG1879@2|Bacteria,1TQ1B@1239|Firmicutes,247K8@186801|Clostridia,36DBX@31979|Clostridiaceae	186801|Clostridia	G	PFAM periplasmic binding protein	-	-	-	ko:K10439,ko:K17213	ko02010,ko02030,map02010,map02030	M00212,M00593	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2,3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	Peripla_BP_4
HKD2_k127_360247_4	1121324.CLIT_4c01590	7.854e-180	571.0	COG1063@1|root,COG1063@2|Bacteria,1TPWP@1239|Firmicutes,24ATV@186801|Clostridia	186801|Clostridia	E	Psort location Cytoplasmic, score	ydjJ	-	1.1.1.14	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014	R00875,R01896	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
HKD2_k127_360247_14	293826.Amet_0591	1.283e-60	212.0	COG1070@1|root,COG1070@2|Bacteria,1TQ1I@1239|Firmicutes,247NR@186801|Clostridia,36F3K@31979|Clostridiaceae	186801|Clostridia	G	Carbohydrate kinase, FGGY	xylB	-	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
HKD2_k127_365863_0	641107.CDLVIII_2440	1.877e-194	608.0	COG1979@1|root,COG1979@2|Bacteria,1TPS3@1239|Firmicutes,248DW@186801|Clostridia,36EU1@31979|Clostridiaceae	186801|Clostridia	C	Dehydrogenase	bdhA	GO:0003674,GO:0003824,GO:0004022,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016616,GO:0055114	-	ko:K00100,ko:K19955	ko00650,ko01120,map00650,map01120	-	R03544,R03545	RC00087	ko00000,ko00001,ko01000	-	-	-	Fe-ADH
HKD2_k127_365863_1	931276.Cspa_c32590	6.372e-190	599.0	COG2220@1|root,COG2220@2|Bacteria,1TRRP@1239|Firmicutes,24AQ5@186801|Clostridia,36VHG@31979|Clostridiaceae	186801|Clostridia	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
HKD2_k127_365863_4	994573.T472_0216745	3.893e-75	255.0	COG0716@1|root,COG0716@2|Bacteria,1V465@1239|Firmicutes,24DQZ@186801|Clostridia,36VJI@31979|Clostridiaceae	186801|Clostridia	C	Flavodoxin	-	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_4
HKD2_k127_365863_5	1321778.HMPREF1982_01332	2.885e-08	56.0	COG0778@1|root,COG0778@2|Bacteria	2|Bacteria	C	coenzyme F420-1:gamma-L-glutamate ligase activity	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
HKD2_k127_365863_2	1410653.JHVC01000032_gene1027	1.378e-112	365.0	COG0655@1|root,COG0655@2|Bacteria,1TT84@1239|Firmicutes,248W0@186801|Clostridia,36E3H@31979|Clostridiaceae	186801|Clostridia	S	NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
HKD2_k127_3666415_1	1123009.AUID01000015_gene2010	1.931e-73	256.0	COG0609@1|root,COG0609@2|Bacteria,1TPX6@1239|Firmicutes,248IS@186801|Clostridia,268QW@186813|unclassified Clostridiales	186801|Clostridia	P	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily	-	-	-	ko:K02015	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	FecCD
HKD2_k127_3666415_0	1123009.AUID01000015_gene2009	9.097e-106	357.0	COG1120@1|root,COG1120@2|Bacteria,1TP2Q@1239|Firmicutes,2492Z@186801|Clostridia,268XQ@186813|unclassified Clostridiales	186801|Clostridia	HP	ATPases associated with a variety of cellular activities	-	-	3.6.3.34	ko:K02013	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14	-	-	ABC_tran
HKD2_k127_3666415_2	1123009.AUID01000015_gene2008	1.666e-33	134.0	COG0614@1|root,COG0614@2|Bacteria,1UNE3@1239|Firmicutes,24AKE@186801|Clostridia,26962@186813|unclassified Clostridiales	186801|Clostridia	P	Periplasmic binding protein	yvrC	-	-	ko:K02016	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	Peripla_BP_2
HKD2_k127_376151_3	768710.DesyoDRAFT_0175	3.07e-18	85.0	COG1924@1|root,COG1924@2|Bacteria,1TPU5@1239|Firmicutes,2481F@186801|Clostridia,264PX@186807|Peptococcaceae	186801|Clostridia	I	PFAM BadF BadG BcrA BcrD ATPase family	-	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG
HKD2_k127_376151_0	1131730.BAVI_06674	2.015e-87	291.0	COG1670@1|root,COG1670@2|Bacteria,1UWQZ@1239|Firmicutes,4I3IY@91061|Bacilli,1ZEDU@1386|Bacillus	91061|Bacilli	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
HKD2_k127_376151_2	1121472.AQWN01000004_gene672	1.089e-67	232.0	COG2606@1|root,COG2606@2|Bacteria,1V3MU@1239|Firmicutes,24HH2@186801|Clostridia,261Y6@186807|Peptococcaceae	186801|Clostridia	S	PFAM YbaK prolyl-tRNA synthetases associated domain	EbsC	-	-	-	-	-	-	-	-	-	-	-	tRNA_edit
HKD2_k127_377559_1	588581.Cpap_3098	5.086e-122	394.0	COG0443@1|root,COG0443@2|Bacteria,1TP1J@1239|Firmicutes,248QV@186801|Clostridia,3WGES@541000|Ruminococcaceae	186801|Clostridia	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
HKD2_k127_377559_4	986075.CathTA2_2226	4.231e-38	149.0	COG0576@1|root,COG0576@2|Bacteria,1V6G2@1239|Firmicutes,4HIRK@91061|Bacilli	91061|Bacilli	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	grpE	GO:0000166,GO:0000774,GO:0001871,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0008150,GO:0009986,GO:0017076,GO:0030234,GO:0030246,GO:0030247,GO:0030554,GO:0036094,GO:0044464,GO:0050790,GO:0051082,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0097159,GO:0098772,GO:1901265,GO:1901363,GO:2001065	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
HKD2_k127_377559_3	1304284.L21TH_1370	3.217e-97	329.0	COG1420@1|root,COG1420@2|Bacteria,1TQP7@1239|Firmicutes,247K2@186801|Clostridia,36DW8@31979|Clostridiaceae	186801|Clostridia	K	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons	hrcA	-	-	ko:K03705	-	-	-	-	ko00000,ko03000	-	-	-	HrcA,HrcA_DNA-bdg
HKD2_k127_377559_2	203119.Cthe_1325	1.637e-111	371.0	COG0635@1|root,COG0635@2|Bacteria,1TPES@1239|Firmicutes,247P8@186801|Clostridia,3WGN4@541000|Ruminococcaceae	186801|Clostridia	H	Involved in the biosynthesis of porphyrin-containing compound	hemN	-	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
HKD2_k127_377559_0	1163671.JAGI01000002_gene2834	2.324e-163	518.0	COG0481@1|root,COG0481@2|Bacteria,1TP0G@1239|Firmicutes,247V8@186801|Clostridia,36EZX@31979|Clostridiaceae	186801|Clostridia	M	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner	lepA	-	-	ko:K03596	ko05134,map05134	-	-	-	ko00000,ko00001	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2,LepA_C
HKD2_k127_3823549_3	86416.Clopa_0629	2.485e-10	67.0	2EJ6V@1|root,33CY2@2|Bacteria,1VPDN@1239|Firmicutes,24PMK@186801|Clostridia,36M4P@31979|Clostridiaceae	186801|Clostridia	S	Yip1 domain	-	-	-	-	-	-	-	-	-	-	-	-	Yip1
HKD2_k127_3823549_1	1230342.CTM_05850	1.951e-143	466.0	COG1215@1|root,COG1215@2|Bacteria,1TRCI@1239|Firmicutes,248JA@186801|Clostridia,36EW1@31979|Clostridiaceae	186801|Clostridia	M	glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3
HKD2_k127_3823549_4	318464.IO99_18075	3.719e-07	60.0	COG1266@1|root,COG1266@2|Bacteria,1VHZJ@1239|Firmicutes,24FYT@186801|Clostridia,36I9B@31979|Clostridiaceae	186801|Clostridia	S	CAAX protease self-immunity	-	-	-	-	-	-	-	-	-	-	-	-	Abi
HKD2_k127_3823549_2	1121342.AUCO01000003_gene1530	9.882e-66	229.0	COG0218@1|root,COG0218@2|Bacteria,1TSPW@1239|Firmicutes,24836@186801|Clostridia,36EDR@31979|Clostridiaceae	186801|Clostridia	D	Necessary for normal cell division and for the maintenance of normal septation	engB	-	-	ko:K03978	-	-	-	-	ko00000,ko03036	-	-	-	MMR_HSR1
HKD2_k127_3823549_0	350688.Clos_2171	8.142e-305	947.0	COG0466@1|root,COG0466@2|Bacteria,1TNYG@1239|Firmicutes,247SH@186801|Clostridia,36DMT@31979|Clostridiaceae	186801|Clostridia	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
HKD2_k127_3836496_1	509191.AEDB02000067_gene892	6.779e-176	560.0	COG1109@1|root,COG1109@2|Bacteria,1TP1X@1239|Firmicutes,2499P@186801|Clostridia,3WGDW@541000|Ruminococcaceae	186801|Clostridia	G	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate	glmM	-	5.4.2.10	ko:K03431	ko00520,ko01100,ko01130,map00520,map01100,map01130	-	R02060	RC00408	ko00000,ko00001,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
HKD2_k127_3836496_0	1499684.CCNP01000018_gene1482	9.012e-220	696.0	COG0018@1|root,COG0018@2|Bacteria,1TPEZ@1239|Firmicutes,248JZ@186801|Clostridia,36DCT@31979|Clostridiaceae	186801|Clostridia	J	Arginyl-tRNA synthetase	argS	-	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
HKD2_k127_3837604_2	1121342.AUCO01000027_gene1253	1.265e-138	445.0	COG0165@1|root,COG0165@2|Bacteria,1TNZ6@1239|Firmicutes,2489H@186801|Clostridia,36E9J@31979|Clostridiaceae	186801|Clostridia	E	argininosuccinate lyase	argH	-	4.3.2.1	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01086	RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ASL_C2,Lyase_1
HKD2_k127_3837604_4	1294142.CINTURNW_4287	1.984e-56	200.0	COG1846@1|root,COG1846@2|Bacteria,1V6G0@1239|Firmicutes,24K11@186801|Clostridia,36JJU@31979|Clostridiaceae	186801|Clostridia	K	MarR family	ohrR	-	-	-	-	-	-	-	-	-	-	-	MarR
HKD2_k127_3837604_1	1195236.CTER_3392	7.33e-174	562.0	COG5001@1|root,COG5001@2|Bacteria,1TP8V@1239|Firmicutes,247PX@186801|Clostridia,3WNHQ@541000|Ruminococcaceae	186801|Clostridia	T	Putative diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	ABC_sub_bind,EAL,GGDEF,PAS_3,PAS_9,PocR
HKD2_k127_3837604_5	1280390.CBQR020000153_gene4151	5.969e-27	114.0	COG5001@1|root,COG5001@2|Bacteria,1TP8V@1239|Firmicutes,4HA3G@91061|Bacilli,26QWH@186822|Paenibacillaceae	91061|Bacilli	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	5TM-5TMR_LYT,EAL,GAF_2,GGDEF,PAS_3,PAS_4,PAS_9,Peripla_BP_3
HKD2_k127_3837604_3	1195236.CTER_3393	5.182e-103	348.0	COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1V5DN@1239|Firmicutes,25BEF@186801|Clostridia	186801|Clostridia	K	response regulator receiver	-	-	-	ko:K07720	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_18,Response_reg
HKD2_k127_3837604_0	1195236.CTER_3394	7.578e-227	722.0	COG2984@1|root,COG4251@1|root,COG2984@2|Bacteria,COG4251@2|Bacteria,1V0TU@1239|Firmicutes,24FNP@186801|Clostridia,3WPFW@541000|Ruminococcaceae	186801|Clostridia	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_9
HKD2_k127_3855778_4	1449126.JQKL01000030_gene2506	2.379e-70	240.0	COG2210@1|root,COG2210@2|Bacteria,1UIFM@1239|Firmicutes,24H1I@186801|Clostridia	186801|Clostridia	S	DsrE/DsrF/DrsH-like family	-	-	-	-	-	-	-	-	-	-	-	-	DrsE_2
HKD2_k127_3855778_8	509191.AEDB02000064_gene499	3.855e-15	87.0	29ZKM@1|root,30MM0@2|Bacteria,1VH7W@1239|Firmicutes,24IB6@186801|Clostridia,3WNAC@541000|Ruminococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3855778_7	350688.Clos_0551	1.134e-41	162.0	COG4478@1|root,COG4478@2|Bacteria,1VA1P@1239|Firmicutes,24N7Q@186801|Clostridia,36M4U@31979|Clostridiaceae	186801|Clostridia	S	TIGRFAM integral membrane protein TIGR01906	-	-	-	-	-	-	-	-	-	-	-	-	DUF1461
HKD2_k127_3855778_5	1121289.JHVL01000049_gene872	1.592e-62	226.0	COG5401@1|root,COG5401@2|Bacteria,1UXYS@1239|Firmicutes,24EK4@186801|Clostridia,36JB7@31979|Clostridiaceae	186801|Clostridia	S	Sporulation and spore germination	-	-	-	ko:K06298	-	-	-	-	ko00000	-	-	-	Germane
HKD2_k127_3855778_6	1304284.L21TH_1003	3.415e-51	194.0	COG1266@1|root,COG1266@2|Bacteria,1V1B4@1239|Firmicutes,25CEY@186801|Clostridia,36WUT@31979|Clostridiaceae	186801|Clostridia	S	PFAM Abortive infection protein	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
HKD2_k127_3855778_1	1391647.AVSV01000021_gene2278	1.983e-93	316.0	COG0492@1|root,COG0492@2|Bacteria,1TNZS@1239|Firmicutes,2491M@186801|Clostridia,36E20@31979|Clostridiaceae	186801|Clostridia	C	Thioredoxin reductase	trxB	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
HKD2_k127_3855778_0	941824.TCEL_00381	5.964e-177	565.0	COG0641@1|root,COG0641@2|Bacteria,1TQPS@1239|Firmicutes,248DD@186801|Clostridia,36DZR@31979|Clostridiaceae	186801|Clostridia	C	Radical SAM	scfB	-	-	ko:K06871	-	-	-	-	ko00000	-	-	-	Fer4_12,Radical_SAM,SPASM
HKD2_k127_3855778_3	1128398.Curi_c12550	1.236e-78	267.0	COG4869@1|root,COG4869@2|Bacteria,1V242@1239|Firmicutes,24816@186801|Clostridia,268VD@186813|unclassified Clostridiales	186801|Clostridia	Q	Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate	pduL	-	2.3.1.8	ko:K15024	ko00430,ko00620,ko00640,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00720,map01100,map01120,map01200	M00579	R00230,R00921	RC00004,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000	-	-	-	Cob_adeno_trans,PTAC
HKD2_k127_3855778_2	457396.CSBG_01956	6.351e-89	298.0	COG0274@1|root,COG0274@2|Bacteria,1TPAJ@1239|Firmicutes,249XB@186801|Clostridia,36DTB@31979|Clostridiaceae	186801|Clostridia	F	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate	deoC	-	4.1.2.4	ko:K01619	ko00030,map00030	-	R01066	RC00436,RC00437	ko00000,ko00001,ko01000	-	-	-	DeoC
HKD2_k127_3860661_14	536227.CcarbDRAFT_3472	2.054e-22	98.0	COG1977@1|root,COG1977@2|Bacteria,1VIST@1239|Firmicutes,24QYP@186801|Clostridia,36NC4@31979|Clostridiaceae	186801|Clostridia	H	ThiS family	moaD	-	-	-	-	-	-	-	-	-	-	-	ThiS
HKD2_k127_3860661_8	536227.CcarbDRAFT_3473	7.254e-88	295.0	COG0476@1|root,COG0476@2|Bacteria,1TQ3U@1239|Firmicutes,25CJC@186801|Clostridia,36GDP@31979|Clostridiaceae	186801|Clostridia	H	UBA THIF-type NAD FAD binding protein	moeB	-	2.7.7.80	ko:K21029	ko04122,map04122	-	R07459	RC00043	ko00000,ko00001,ko01000	-	-	-	ThiF
HKD2_k127_3860661_3	1304284.L21TH_2295	1.321e-179	578.0	COG1080@1|root,COG1080@2|Bacteria,1TPK8@1239|Firmicutes,248QP@186801|Clostridia,36DCW@31979|Clostridiaceae	186801|Clostridia	G	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)	ptsP	-	2.7.3.9,2.7.9.2	ko:K01007,ko:K08483	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,ko02060,map00620,map00680,map00720,map01100,map01120,map01200,map02060	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko02000	8.A.7	-	-	PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C
HKD2_k127_3860661_6	1031288.AXAA01000006_gene1082	3.672e-113	369.0	COG0363@1|root,COG0363@2|Bacteria,1TP10@1239|Firmicutes,248HK@186801|Clostridia,36E4F@31979|Clostridiaceae	186801|Clostridia	G	Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion	nagB	-	3.5.99.6	ko:K02564	ko00520,ko01100,map00520,map01100	-	R00765	RC00163	ko00000,ko00001,ko01000	-	-	-	Glucosamine_iso
HKD2_k127_3860661_5	1408422.JHYF01000008_gene3656	9.462e-129	421.0	COG1820@1|root,COG1820@2|Bacteria,1TPFK@1239|Firmicutes,2481N@186801|Clostridia,36FD4@31979|Clostridiaceae	186801|Clostridia	G	Belongs to the metallo-dependent hydrolases superfamily. NagA family	nagA	-	3.5.1.25	ko:K01443	ko00520,ko01130,map00520,map01130	-	R02059	RC00166,RC00300	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
HKD2_k127_3860661_4	1408422.JHYF01000008_gene3657	1.007e-165	527.0	COG3589@1|root,COG3589@2|Bacteria,1TRIY@1239|Firmicutes,248R7@186801|Clostridia,36EAB@31979|Clostridiaceae	186801|Clostridia	S	hmm pf05913	-	-	-	ko:K09963	-	-	-	-	ko00000	-	-	-	DUF871
HKD2_k127_3860661_12	1408422.JHYF01000008_gene3658	9.14e-35	136.0	COG1447@1|root,COG1447@2|Bacteria,1VEGE@1239|Firmicutes,24QKT@186801|Clostridia,36MWQ@31979|Clostridiaceae	186801|Clostridia	G	phosphotransferase system	-	-	2.7.1.196,2.7.1.205	ko:K02759	ko00500,ko02060,map00500,map02060	M00275	R11170,R11172	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.3.2	-	-	PTS_IIA
HKD2_k127_3860661_2	1408422.JHYF01000008_gene3660	1.433e-191	606.0	COG1455@1|root,COG1455@2|Bacteria,1TP8D@1239|Firmicutes,24808@186801|Clostridia,36E10@31979|Clostridiaceae	186801|Clostridia	G	The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active - transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane	-	-	-	ko:K02761	ko00500,ko02060,map00500,map02060	M00275	R11170,R11172	RC00017,RC03206	ko00000,ko00001,ko00002,ko02000	4.A.3.2	-	-	PTS_EIIC
HKD2_k127_3860661_13	1408422.JHYF01000008_gene3661	4.776e-30	123.0	COG1440@1|root,COG1440@2|Bacteria,1VADE@1239|Firmicutes,24R71@186801|Clostridia,36M9S@31979|Clostridiaceae	186801|Clostridia	G	system, Lactose	licB	-	2.7.1.196,2.7.1.205	ko:K02760	ko00500,ko02060,map00500,map02060	M00275	R11170,R11172	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.3.2	-	-	PTS_IIB
HKD2_k127_3860661_15	1391646.AVSU01000092_gene436	1.203e-16	82.0	COG1925@1|root,COG1925@2|Bacteria,1VA0R@1239|Firmicutes,24QIP@186801|Clostridia,25RTM@186804|Peptostreptococcaceae	186801|Clostridia	G	phosphocarrier protein HPr	ptsH	-	-	ko:K02784,ko:K11189	ko02060,map02060	-	-	-	ko00000,ko00001,ko02000	4.A.2.1,8.A.8.1.1	-	-	PTS-HPr
HKD2_k127_3860661_0	1408422.JHYF01000008_gene3664	0.0	1044.0	COG1221@1|root,COG3933@1|root,COG1221@2|Bacteria,COG3933@2|Bacteria,1VSHE@1239|Firmicutes,248QH@186801|Clostridia,36ECX@31979|Clostridiaceae	186801|Clostridia	K	system, fructose subfamily, IIA component	-	-	-	-	-	-	-	-	-	-	-	-	EIIA-man,PRD,Sigma54_activat,TrmB
HKD2_k127_3860661_1	293826.Amet_0679	1.158e-201	635.0	COG0493@1|root,COG0493@2|Bacteria,1TQ1A@1239|Firmicutes,248EK@186801|Clostridia,36E1P@31979|Clostridiaceae	186801|Clostridia	C	glutamate synthase (NADPH), homotetrameric	-	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4_20,Pyr_redox_2,Pyr_redox_3
HKD2_k127_3860661_11	666686.B1NLA3E_18310	3.985e-49	183.0	COG1309@1|root,COG1309@2|Bacteria,1TPXF@1239|Firmicutes,4HCMD@91061|Bacilli,1ZDYI@1386|Bacillus	91061|Bacilli	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
HKD2_k127_3860661_10	666686.B1NLA3E_18315	3.551e-78	268.0	COG0348@1|root,COG0348@2|Bacteria,1V66G@1239|Firmicutes	1239|Firmicutes	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_10,Fer4_5,Fer4_9
HKD2_k127_3860661_9	913865.DOT_5156	8.29e-88	295.0	COG2364@1|root,COG2364@2|Bacteria,1V47R@1239|Firmicutes,24AXT@186801|Clostridia,262F4@186807|Peptococcaceae	186801|Clostridia	S	BCR, YitT family COG1284	-	-	-	ko:K07149	-	-	-	-	ko00000	-	-	-	-
HKD2_k127_3860661_7	86416.Clopa_4284	9.389e-101	340.0	COG0784@1|root,COG5002@1|root,COG0784@2|Bacteria,COG5002@2|Bacteria,1TSDF@1239|Firmicutes,250SJ@186801|Clostridia,36UMN@31979|Clostridiaceae	186801|Clostridia	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	4HB_MCP_1,GAF_2,HATPase_c,HisKA,Hpt,Response_reg
HKD2_k127_3896036_2	1304284.L21TH_1605	5.712e-93	310.0	COG0166@1|root,COG0166@2|Bacteria,1TP29@1239|Firmicutes,2487A@186801|Clostridia,36DWA@31979|Clostridiaceae	186801|Clostridia	G	Belongs to the GPI family	pgi	-	5.3.1.9	ko:K01810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114	R02739,R02740,R03321	RC00376,RC00563	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGI
HKD2_k127_3896036_1	1487921.DP68_02180	3.703e-94	318.0	COG1940@1|root,COG1940@2|Bacteria,1TPKW@1239|Firmicutes,248U9@186801|Clostridia,36ESA@31979|Clostridiaceae	186801|Clostridia	GK	ROK family	glcK	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
HKD2_k127_3896036_0	1304284.L21TH_1095	2.531e-104	349.0	COG2206@1|root,COG2206@2|Bacteria,1TQIM@1239|Firmicutes,248S5@186801|Clostridia,36FJB@31979|Clostridiaceae	186801|Clostridia	T	SMART Metal-dependent phosphohydrolase, HD region	-	-	-	-	-	-	-	-	-	-	-	-	HD,HD_5
HKD2_k127_3898222_1	1192034.CAP_3470	4.624e-07	60.0	2AIUZ@1|root,319C5@2|Bacteria,1Q2AQ@1224|Proteobacteria,437XB@68525|delta/epsilon subdivisions,2X9R0@28221|Deltaproteobacteria,2Z0BZ@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3898222_0	350688.Clos_1783	3.442e-53	194.0	COG1739@1|root,COG1739@2|Bacteria,1V6MQ@1239|Firmicutes,248W7@186801|Clostridia,36FC7@31979|Clostridiaceae	186801|Clostridia	S	Uncharacterized protein family UPF0029	yvyE	-	-	-	-	-	-	-	-	-	-	-	DUF1949,UPF0029
HKD2_k127_3898222_2	755731.Clo1100_1771	6.424e-05	50.0	2EMBR@1|root,33F0Q@2|Bacteria,1VPIQ@1239|Firmicutes,24UA7@186801|Clostridia,36Q3X@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3936216_0	1347392.CCEZ01000018_gene1131	9.305e-210	662.0	COG0332@1|root,COG0332@2|Bacteria,1TQSB@1239|Firmicutes,2499C@186801|Clostridia,36FF2@31979|Clostridiaceae	186801|Clostridia	I	3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III	grdC	-	1.21.4.2,1.21.4.3,1.21.4.4	ko:K21577	-	-	-	-	ko00000,ko01000	-	-	-	ACP_syn_III
HKD2_k127_3936216_1	857293.CAAU_2352	3.352e-162	519.0	COG0416@1|root,COG0416@2|Bacteria,1TPY8@1239|Firmicutes,248BX@186801|Clostridia,36EUZ@31979|Clostridiaceae	186801|Clostridia	I	PFAM fatty acid synthesis plsX protein	grdD	-	1.21.4.2,1.21.4.3,1.21.4.4	ko:K21576	-	-	-	-	ko00000,ko01000	-	-	-	FA_synthesis
HKD2_k127_3936216_2	941824.TCEL_00708	1.641e-98	332.0	COG1744@1|root,COG1744@2|Bacteria,1TPEU@1239|Firmicutes,248QT@186801|Clostridia,36EW8@31979|Clostridiaceae	186801|Clostridia	S	basic membrane	-	-	-	ko:K07335	-	-	-	-	ko00000	-	-	-	Bmp
HKD2_k127_3936216_3	941824.TCEL_00707	1.656e-25	109.0	COG3845@1|root,COG3845@2|Bacteria,1UYQA@1239|Firmicutes,24XN8@186801|Clostridia,36UI0@31979|Clostridiaceae	186801|Clostridia	S	ABC transporter	yufO	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
HKD2_k127_393708_10	1196028.ALEF01000069_gene1565	1.761e-36	142.0	COG1387@1|root,COG1387@2|Bacteria,1TRKS@1239|Firmicutes,4HC0G@91061|Bacilli,4C5C6@84406|Virgibacillus	91061|Bacilli	E	DNA polymerase alpha chain like domain	hisK	-	3.1.3.15	ko:K04486	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R03013	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PHP
HKD2_k127_393708_5	1121289.JHVL01000013_gene1624	1.734e-66	230.0	2CK8D@1|root,32SBU@2|Bacteria,1VAQG@1239|Firmicutes,24HSZ@186801|Clostridia,36IQJ@31979|Clostridiaceae	186801|Clostridia	S	Tryptophan transporter TrpP	trpP	-	-	-	-	-	-	-	-	-	-	iHN637.CLJU_RS14305	TrpP
HKD2_k127_393708_0	1499689.CCNN01000007_gene2361	4.505e-241	753.0	COG1190@1|root,COG1190@2|Bacteria,1TP2P@1239|Firmicutes,24DSH@186801|Clostridia,36ER2@31979|Clostridiaceae	186801|Clostridia	J	Belongs to the class-II aminoacyl-tRNA synthetase family	-	-	6.1.1.6	ko:K04567	ko00970,map00970	M00359,M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
HKD2_k127_393708_6	1499968.TCA2_0660	1.114e-62	222.0	COG0637@1|root,COG0637@2|Bacteria,1UY8N@1239|Firmicutes,4IQDJ@91061|Bacilli,276BC@186822|Paenibacillaceae	91061|Bacilli	S	Catalyzes the interconversion of beta-D-glucose 6-phosphate to beta-D-glucose 1-phosphate	-	-	5.4.2.6	ko:K01838	ko00500,map00500	-	R02728,R11310	RC00408	ko00000,ko00001,ko01000	-	-	-	HAD_2
HKD2_k127_393708_1	743719.PaelaDRAFT_3471	8.256e-241	765.0	COG1554@1|root,COG1554@2|Bacteria,1TQMB@1239|Firmicutes,4HAVB@91061|Bacilli,26TAI@186822|Paenibacillaceae	91061|Bacilli	G	Glycosyl hydrolase family 65, N-terminal domain	treP	-	2.4.1.64	ko:K05342	ko00500,ko01100,map00500,map01100	-	R02727	RC00049	ko00000,ko00001,ko01000	-	GH65	-	Glyco_hydro_65C,Glyco_hydro_65N,Glyco_hydro_65m
HKD2_k127_393708_4	1033810.HLPCO_001261	1.914e-117	383.0	COG0395@1|root,COG0395@2|Bacteria,2NPBC@2323|unclassified Bacteria	2|Bacteria	U	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02026,ko:K10238	ko02010,map02010	M00204,M00207	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.17	-	-	BPD_transp_1
HKD2_k127_393708_3	1033810.HLPCO_001262	2.446e-130	428.0	COG1175@1|root,COG1175@2|Bacteria,2NPAH@2323|unclassified Bacteria	2|Bacteria	U	Binding-protein-dependent transport system inner membrane component	thuF	GO:0008150,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044403,GO:0044419,GO:0051704	-	ko:K02025,ko:K10237,ko:K15771	ko02010,map02010	M00204,M00207,M00491	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.16,3.A.1.1.17,3.A.1.1.2	-	iNJ661.Rv1236	BPD_transp_1
HKD2_k127_393708_2	1033810.HLPCO_001263	4.404e-158	508.0	COG1653@1|root,COG1653@2|Bacteria,2NP9E@2323|unclassified Bacteria	2|Bacteria	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1,SBP_bac_8
HKD2_k127_393708_8	345219.Bcoa_0677	6.218e-55	200.0	COG2207@1|root,COG2207@2|Bacteria,1U23Q@1239|Firmicutes,4HBWX@91061|Bacilli,1ZCEA@1386|Bacillus	91061|Bacilli	K	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18,HTH_AraC
HKD2_k127_393708_9	1321778.HMPREF1982_02003	1.733e-51	187.0	COG2096@1|root,COG2096@2|Bacteria,1V3PI@1239|Firmicutes	1239|Firmicutes	S	ATP cob(I)alamin adenosyltransferase	yvqK	-	2.5.1.17	ko:K00798	ko00860,ko01100,map00860,map01100	M00122	R01492,R05220,R07268	RC00533	ko00000,ko00001,ko00002,ko01000	-	-	-	Cob_adeno_trans,Haem_degrading
HKD2_k127_393708_7	1408422.JHYF01000017_gene1844	6.889e-58	207.0	COG1301@1|root,COG1301@2|Bacteria,1TPME@1239|Firmicutes,247UX@186801|Clostridia,36DYZ@31979|Clostridiaceae	186801|Clostridia	C	Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family	-	-	-	-	-	-	-	-	-	-	-	-	SDF
HKD2_k127_393885_3	588581.Cpap_2977	1.986e-47	176.0	COG0757@1|root,COG0757@2|Bacteria,1V6E8@1239|Firmicutes,24JBK@186801|Clostridia,3WIYS@541000|Ruminococcaceae	186801|Clostridia	E	Catalyzes a trans-dehydration via an enolate intermediate	aroQ	-	4.2.1.10	ko:K03786	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03084	RC00848	ko00000,ko00001,ko00002,ko01000	-	-	-	DHquinase_II
HKD2_k127_393885_4	1123376.AUIU01000011_gene1075	5.15e-32	130.0	COG0703@1|root,COG0703@2|Bacteria,3J0R8@40117|Nitrospirae	40117|Nitrospirae	F	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate	aroK	GO:0000287,GO:0003674,GO:0003824,GO:0004765,GO:0005488,GO:0006082,GO:0006520,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019438,GO:0019632,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046872,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615	2.7.1.71	ko:K00891	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	SKI
HKD2_k127_393885_5	580327.Tthe_1286	6.742e-24	103.0	2DNY2@1|root,32ZR4@2|Bacteria,1VEGZ@1239|Firmicutes,24RGC@186801|Clostridia,42H2A@68295|Thermoanaerobacterales	186801|Clostridia	S	PFAM Late competence development protein ComFB	comFB	-	-	ko:K02241	-	M00429	-	-	ko00000,ko00002,ko02044	-	-	-	ComFB
HKD2_k127_393885_0	1304284.L21TH_1832	4.744e-73	254.0	COG1989@1|root,COG1989@2|Bacteria,1TQY4@1239|Firmicutes,24HC0@186801|Clostridia,36H8M@31979|Clostridiaceae	186801|Clostridia	NOU	peptidase	hofD	-	3.4.23.43	ko:K02654	-	M00331	-	-	ko00000,ko00002,ko01000,ko01002,ko02035,ko02044	3.A.15.2	-	-	DiS_P_DiS,Peptidase_A24
HKD2_k127_393885_2	293826.Amet_2482	1.595e-49	181.0	COG2179@1|root,COG2179@2|Bacteria,1V6KM@1239|Firmicutes,24KK7@186801|Clostridia,36J9U@31979|Clostridiaceae	186801|Clostridia	S	HAD superfamily (Subfamily IIIA) phosphatase	yqeG	-	-	ko:K07015	-	-	-	-	ko00000	-	-	-	HAD_2,Hydrolase,Hydrolase_like,PGP_phosphatase
HKD2_k127_393885_1	1304284.L21TH_1842	6.926e-56	198.0	COG1191@1|root,COG1191@2|Bacteria,1TPJ5@1239|Firmicutes,247XH@186801|Clostridia,36EDZ@31979|Clostridiaceae	186801|Clostridia	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	sigK	-	-	ko:K03091	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4
HKD2_k127_3995021_4	1304284.L21TH_1693	2.466e-35	137.0	28ZRY@1|root,2ZMGR@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3995021_3	398512.JQKC01000007_gene1180	1.839e-68	234.0	COG0437@1|root,COG0437@2|Bacteria,1VBE5@1239|Firmicutes,24PM1@186801|Clostridia	186801|Clostridia	C	4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_11,Fer4_4,Fer4_9
HKD2_k127_3995021_0	398512.JQKC01000007_gene1179	2.213e-284	882.0	COG2414@1|root,COG2414@2|Bacteria,1TPT9@1239|Firmicutes,2481Q@186801|Clostridia,3WQA7@541000|Ruminococcaceae	186801|Clostridia	C	Aldehyde ferredoxin oxidoreductase, N-terminal domain	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
HKD2_k127_3995021_1	935948.KE386494_gene558	1.552e-231	730.0	COG1252@1|root,COG1252@2|Bacteria,1TR6X@1239|Firmicutes,249J5@186801|Clostridia,42FI1@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	1.6.99.3	ko:K03885	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	DoxD,DoxX,Pyr_redox_2
HKD2_k127_3995021_2	386415.NT01CX_1662	4.834e-131	422.0	COG1026@1|root,COG1026@2|Bacteria,1TPD1@1239|Firmicutes,258W0@186801|Clostridia,36DD6@31979|Clostridiaceae	186801|Clostridia	S	Peptidase M16	-	-	-	ko:K06972	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	HsdM_N,M16C_assoc,Peptidase_M16,Peptidase_M16_C,SLH
HKD2_k127_4000527_0	1226325.HMPREF1548_05016	4.47e-189	599.0	COG0006@1|root,COG0006@2|Bacteria,1TQ44@1239|Firmicutes,247SG@186801|Clostridia,36FFH@31979|Clostridiaceae	186801|Clostridia	E	aminopeptidase	pepP	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	AMP_N,Peptidase_M24
HKD2_k127_4000527_1	509191.AEDB02000059_gene405	5.076e-168	541.0	COG0768@1|root,COG0768@2|Bacteria,1TPER@1239|Firmicutes,2486R@186801|Clostridia,3WG7Q@541000|Ruminococcaceae	186801|Clostridia	M	Cell division protein FtsI penicillin-binding protein 2	ftsI	-	-	ko:K05364	ko00550,map00550	-	R04519	RC00005,RC00049	ko00000,ko00001,ko01011	-	-	-	Transpeptidase
HKD2_k127_4000527_2	398512.JQKC01000022_gene3639	8.088e-147	477.0	COG0772@1|root,COG0772@2|Bacteria,1TQ82@1239|Firmicutes,248QS@186801|Clostridia,3WI1Z@541000|Ruminococcaceae	186801|Clostridia	D	Belongs to the SEDS family	ftsW	-	-	ko:K03588	ko04112,map04112	-	-	-	ko00000,ko00001,ko02000,ko03036	2.A.103.1	-	-	FHA,FTSW_RODA_SPOVE
HKD2_k127_4000527_3	398512.JQKC01000022_gene3638	6.647e-31	125.0	COG1716@1|root,COG1716@2|Bacteria,1VF0E@1239|Firmicutes,25MV3@186801|Clostridia,3WPWA@541000|Ruminococcaceae	186801|Clostridia	T	Inner membrane component of T3SS, cytoplasmic domain	-	-	-	-	-	-	-	-	-	-	-	-	FHA
HKD2_k127_400565_2	203119.Cthe_2256	5.292e-193	611.0	COG0305@1|root,COG0305@2|Bacteria,1TPCT@1239|Firmicutes,247W3@186801|Clostridia,3WH8B@541000|Ruminococcaceae	186801|Clostridia	L	Participates in initiation and elongation during chromosome replication	dnaB	-	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C
HKD2_k127_400565_1	1540257.JQMW01000011_gene2380	4.04e-200	640.0	COG1067@1|root,COG1067@2|Bacteria,1TP2K@1239|Firmicutes,247TX@186801|Clostridia,36E4T@31979|Clostridiaceae	186801|Clostridia	O	Belongs to the peptidase S16 family	lonC	-	3.4.21.53	ko:K01338,ko:K04076	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,Lon_C,RuvB_N
HKD2_k127_400565_3	941824.TCEL_02061	2.198e-46	171.0	COG0359@1|root,COG0359@2|Bacteria,1V6QG@1239|Firmicutes,24MT6@186801|Clostridia,36IT5@31979|Clostridiaceae	186801|Clostridia	J	binds to the 23S rRNA	rplI	-	-	ko:K02939	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L9_C,Ribosomal_L9_N
HKD2_k127_400565_0	1408422.JHYF01000006_gene1045	9.104e-218	694.0	COG3887@1|root,COG3887@2|Bacteria,1TPGP@1239|Firmicutes,2484R@186801|Clostridia,36E60@31979|Clostridiaceae	186801|Clostridia	T	domain protein	yybT	-	-	-	-	-	-	-	-	-	-	-	DHH,DHHA1
HKD2_k127_400565_10	574087.Acear_2328	3.844e-21	105.0	COG4241@1|root,COG4241@2|Bacteria,1V045@1239|Firmicutes,24BZJ@186801|Clostridia,3WAVX@53433|Halanaerobiales	186801|Clostridia	S	Predicted membrane protein (DUF2232)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2232
HKD2_k127_400565_7	1121289.JHVL01000038_gene2982	1.162e-31	128.0	2E81H@1|root,332FJ@2|Bacteria,1VEGN@1239|Firmicutes,24NHK@186801|Clostridia,36JMT@31979|Clostridiaceae	186801|Clostridia	S	MazG-like family	-	-	-	-	-	-	-	-	-	-	-	-	MazG-like
HKD2_k127_400565_6	1230342.CTM_20114	1.314e-34	134.0	COG0238@1|root,COG0238@2|Bacteria,1V9XS@1239|Firmicutes,24MQV@186801|Clostridia,36KGE@31979|Clostridiaceae	186801|Clostridia	J	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit	rpsR	-	-	ko:K02963	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S18
HKD2_k127_400565_4	755731.Clo1100_0067	3.008e-45	167.0	COG0629@1|root,COG0629@2|Bacteria,1V3WT@1239|Firmicutes,24HF9@186801|Clostridia,36IQ6@31979|Clostridiaceae	186801|Clostridia	L	Single-stranded DNA-binding protein	ssb	-	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
HKD2_k127_400565_8	509191.AEDB02000052_gene1362	1.003e-28	118.0	COG0360@1|root,COG0360@2|Bacteria,1VA18@1239|Firmicutes,24QZQ@186801|Clostridia,3WKNW@541000|Ruminococcaceae	186801|Clostridia	J	Binds together with S18 to 16S ribosomal RNA	rpsF	-	-	ko:K02990	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S6
HKD2_k127_400565_9	1031288.AXAA01000015_gene326	1.044e-27	113.0	COG4481@1|root,COG4481@2|Bacteria,1VEQ7@1239|Firmicutes,24QKA@186801|Clostridia,36MMG@31979|Clostridiaceae	186801|Clostridia	S	Bacterial protein of unknown function (DUF951)	-	-	-	-	-	-	-	-	-	-	-	-	DUF951
HKD2_k127_400565_5	1121430.JMLG01000002_gene1306	9.231e-45	166.0	COG0668@1|root,COG0668@2|Bacteria,1TR9Z@1239|Firmicutes,24CAG@186801|Clostridia,261ME@186807|Peptococcaceae	186801|Clostridia	M	Mechanosensitive ion channel	mscS	GO:0003674,GO:0005488,GO:0005515,GO:0042802	-	ko:K16052,ko:K22044	-	-	-	-	ko00000,ko02000	1.A.23.3,1.A.23.4	-	-	MS_channel
HKD2_k127_4034085_7	1304284.L21TH_2355	1.516e-39	147.0	COG1978@1|root,COG1978@2|Bacteria,1TPAB@1239|Firmicutes,2487X@186801|Clostridia,36DEZ@31979|Clostridiaceae	186801|Clostridia	S	glycine betaine sarcosine D-proline reductase family	grdB	-	1.21.4.2	ko:K10672	-	-	-	-	ko00000,ko01000	-	-	-	GRDB
HKD2_k127_4034085_2	350688.Clos_0958	1.117e-171	544.0	COG1978@1|root,COG1978@2|Bacteria,1TPAB@1239|Firmicutes,2487X@186801|Clostridia,36DEZ@31979|Clostridiaceae	186801|Clostridia	S	glycine betaine sarcosine D-proline reductase family	-	-	1.21.4.2	ko:K10672	-	-	-	-	ko00000,ko01000	-	-	-	GRDB
HKD2_k127_4034085_6	857293.CAAU_2357	4.994e-43	159.0	2AE14@1|root,313TT@2|Bacteria,1V6GX@1239|Firmicutes,24K4C@186801|Clostridia,36JTG@31979|Clostridiaceae	186801|Clostridia	C	In the first step of glycine, betaine and sarcosine reductases, the substrate is bound to component PB via a Schiff base intermediate. Then the PB-activated substrate is nucleophilically attacked by the selenol anion of component PA to transform it to a carboxymethylated selenoether and the respective amine. By action of component PC, acetyl phosphate is formed, leaving component PA in its oxidized state. Finally component PA becomes reduced by the thioredoxin system to start a new catalytic cycle of reductive deamination	grdA	-	1.21.4.2,1.21.4.3,1.21.4.4	ko:K10670	-	-	-	-	ko00000,ko01000	-	-	-	GRDA
HKD2_k127_4034085_11	1163671.JAGI01000002_gene1090	3.292e-16	78.0	2DR3E@1|root,33A02@2|Bacteria,1VKEX@1239|Firmicutes,24UH8@186801|Clostridia,36P60@31979|Clostridiaceae	186801|Clostridia	S	Glycine reductase complex selenoprotein A	grdA	-	1.21.4.2,1.21.4.3,1.21.4.4	ko:K10670	-	-	-	-	ko00000,ko01000	-	-	-	GRDA
HKD2_k127_4034085_1	1511.CLOST_1110	1.489e-213	669.0	28HF7@1|root,2Z7RC@2|Bacteria,1TQET@1239|Firmicutes,249YW@186801|Clostridia,25QXA@186804|Peptostreptococcaceae	186801|Clostridia	C	Glycine/sarcosine/betaine reductase component B subunits	grdE	-	1.21.4.2	ko:K10671	-	-	-	-	ko00000,ko01000	-	-	-	Gly_reductase
HKD2_k127_4034085_9	292459.STH2871	2.258e-35	138.0	COG3118@1|root,COG3118@2|Bacteria,1UHX3@1239|Firmicutes,24JPM@186801|Clostridia	186801|Clostridia	O	Belongs to the thioredoxin family	trxA	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
HKD2_k127_4034085_4	1321778.HMPREF1982_04175	1.199e-124	406.0	COG0492@1|root,COG0492@2|Bacteria,1TNZS@1239|Firmicutes,2491M@186801|Clostridia,26861@186813|unclassified Clostridiales	186801|Clostridia	C	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family	trxB	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
HKD2_k127_4034085_10	1123009.AUID01000013_gene1734	2.521e-29	121.0	2E36T@1|root,32Y6H@2|Bacteria,1VEXQ@1239|Firmicutes,24RAE@186801|Clostridia,26BZT@186813|unclassified Clostridiales	186801|Clostridia	S	Psort location Cytoplasmic, score	grdX	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4034085_5	272563.CD630_05660	2.901e-70	241.0	COG0219@1|root,COG0219@2|Bacteria,1V3GW@1239|Firmicutes,24HVV@186801|Clostridia,25RBQ@186804|Peptostreptococcaceae	186801|Clostridia	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily	trmL	-	2.1.1.207	ko:K03216	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	SpoU_methylase
HKD2_k127_4034085_8	632292.Calhy_0623	1.177e-36	144.0	COG1406@1|root,COG1406@2|Bacteria,1V6JI@1239|Firmicutes,25DXQ@186801|Clostridia,42H88@68295|Thermoanaerobacterales	186801|Clostridia	N	PFAM CheC domain protein	-	-	-	ko:K03409	ko02030,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheX
HKD2_k127_4034085_0	37659.JNLN01000001_gene2022	2.049e-280	898.0	COG0737@1|root,COG0737@2|Bacteria,1TPV2@1239|Firmicutes,2491Y@186801|Clostridia,36ERD@31979|Clostridiaceae	186801|Clostridia	F	Belongs to the 5'-nucleotidase family	-	-	3.1.3.6,3.1.4.16	ko:K01119	ko00230,ko00240,map00230,map00240	-	R01562,R01877,R02148,R02370,R03537,R03538,R03929,R05135	RC00078,RC00296	ko00000,ko00001,ko01000	-	-	-	5_nucleotid_C,Gram_pos_anchor,LysM,Metallophos
HKD2_k127_4034085_3	1009370.ALO_00985	1.454e-159	511.0	COG1145@1|root,COG2006@1|root,COG1145@2|Bacteria,COG2006@2|Bacteria,1TRX2@1239|Firmicutes,4H3TS@909932|Negativicutes	909932|Negativicutes	C	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362,Fer4,Fer4_6
HKD2_k127_404086_2	1321778.HMPREF1982_04479	1.418e-48	175.0	COG0055@1|root,COG0055@2|Bacteria,1TPGF@1239|Firmicutes,2489W@186801|Clostridia,268HM@186813|unclassified Clostridiales	186801|Clostridia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits	atpD	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_N
HKD2_k127_404086_1	1321778.HMPREF1982_04480	2.865e-117	383.0	COG0224@1|root,COG0224@2|Bacteria,1TPBX@1239|Firmicutes,2486Q@186801|Clostridia,268Q6@186813|unclassified Clostridiales	186801|Clostridia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex	atpG	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt
HKD2_k127_404086_0	1321778.HMPREF1982_04481	5.652e-288	889.0	COG0056@1|root,COG0056@2|Bacteria,1TNZ8@1239|Firmicutes,248IY@186801|Clostridia,2684Y@186813|unclassified Clostridiales	186801|Clostridia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	atpA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
HKD2_k127_404086_3	1499689.CCNN01000007_gene1017	6.224e-11	63.0	COG0712@1|root,COG0712@2|Bacteria,1VAG3@1239|Firmicutes,24MSA@186801|Clostridia,36HY0@31979|Clostridiaceae	186801|Clostridia	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpH	-	-	ko:K02113	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	OSCP
HKD2_k127_4050392_0	1321778.HMPREF1982_03372	0.0	1091.0	COG0043@1|root,COG0043@2|Bacteria,1TQ6V@1239|Firmicutes,248WY@186801|Clostridia	186801|Clostridia	H	Belongs to the UbiD family	-	-	4.1.1.61,4.1.1.98	ko:K03182,ko:K16239	ko00130,ko00627,ko01100,ko01110,ko01120,map00130,map00627,map01100,map01110,map01120	M00117	R01238,R04985,R04986	RC00391	ko00000,ko00001,ko00002,ko01000	-	-	-	UbiD
HKD2_k127_4050392_1	1321778.HMPREF1982_04381	9.453e-27	113.0	2EA57@1|root,334A4@2|Bacteria,1VHEA@1239|Firmicutes,24RNE@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_405049_2	864565.HMPREF0379_0173	9.299e-18	84.0	COG1459@1|root,COG1459@2|Bacteria,1TQRZ@1239|Firmicutes,249FV@186801|Clostridia	186801|Clostridia	NU	type II secretion system	gspF	-	-	ko:K02653	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSF
HKD2_k127_405049_1	796940.HMPREF9628_01433	4.201e-18	88.0	2E4EX@1|root,32ZA3@2|Bacteria,1VEQT@1239|Firmicutes,24QUI@186801|Clostridia,25U5N@186804|Peptostreptococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_405049_4	411902.CLOBOL_02757	7.452e-09	64.0	2E9V5@1|root,33410@2|Bacteria,1VEQY@1239|Firmicutes,24J21@186801|Clostridia,22029@1506553|Lachnoclostridium	186801|Clostridia	S	Domain of unknown function (DUF4860)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4860
HKD2_k127_405049_3	1511.CLOST_0859	1.426e-10	68.0	2BAJ8@1|root,323ZZ@2|Bacteria,1UF1R@1239|Firmicutes,25K2F@186801|Clostridia,25U7Q@186804|Peptostreptococcaceae	186801|Clostridia	S	Pfam:N_methyl_2	-	-	-	-	-	-	-	-	-	-	-	-	N_methyl
HKD2_k127_405049_5	1511.CLOST_0860	9.771e-09	65.0	2C7ZS@1|root,300B5@2|Bacteria,1UF8Z@1239|Firmicutes,25K9P@186801|Clostridia,25UBE@186804|Peptostreptococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_405049_0	1511.CLOST_0861	1.174e-147	474.0	COG2805@1|root,COG2805@2|Bacteria,1TQ5F@1239|Firmicutes,249H9@186801|Clostridia,25SRY@186804|Peptostreptococcaceae	186801|Clostridia	NU	Type II/IV secretion system protein	pilT	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
HKD2_k127_4093021_1	1449050.JNLE01000005_gene4784	2.033e-157	501.0	COG4209@1|root,COG4209@2|Bacteria,1TP33@1239|Firmicutes,248XU@186801|Clostridia,36HN2@31979|Clostridiaceae	186801|Clostridia	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K17319	ko02010,map02010	M00603	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.29,3.A.1.1.9	-	-	BPD_transp_1
HKD2_k127_4093021_2	1449050.JNLE01000005_gene4783	7.818e-146	466.0	COG0395@1|root,COG0395@2|Bacteria,1UYPS@1239|Firmicutes,24BKK@186801|Clostridia,36QTW@31979|Clostridiaceae	186801|Clostridia	G	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K17320	ko02010,map02010	M00603	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.29,3.A.1.1.9	-	-	BPD_transp_1
HKD2_k127_4093021_0	1449050.JNLE01000005_gene4782	2.85e-255	796.0	COG1653@1|root,COG1653@2|Bacteria,1V0NW@1239|Firmicutes,24B7P@186801|Clostridia,36QV7@31979|Clostridiaceae	186801|Clostridia	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K17318	ko02010,map02010	M00603	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.29,3.A.1.1.9	-	-	SBP_bac_8
HKD2_k127_4093021_3	1321778.HMPREF1982_01791	1.413e-28	114.0	COG0500@1|root,COG2226@2|Bacteria,1V1SR@1239|Firmicutes,24K6X@186801|Clostridia	186801|Clostridia	H	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
HKD2_k127_4110133_1	926561.KB900617_gene1467	8.422e-236	733.0	COG0369@1|root,COG1151@2|Bacteria,1TP8X@1239|Firmicutes,247IN@186801|Clostridia	186801|Clostridia	C	Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O	hcp	-	1.7.99.1	ko:K05601	ko00910,map00910	-	R00143	RC02797	ko00000,ko00001,ko01000	-	-	-	Prismane
HKD2_k127_4110133_9	1209989.TepiRe1_0565	7.945e-74	253.0	COG1394@1|root,COG1394@2|Bacteria,1TQ4P@1239|Firmicutes,24Z7J@186801|Clostridia,42HXT@68295|Thermoanaerobacterales	186801|Clostridia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpD	-	-	ko:K02120	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_D
HKD2_k127_4110133_4	1459636.NTE_03278	9.314e-167	536.0	COG1156@1|root,arCOG00865@2157|Archaea,41SPY@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit	atpB	-	-	ko:K02118	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N
HKD2_k127_4110133_0	1209989.TepiRe1_0563	1.31e-267	835.0	COG1155@1|root,COG1155@2|Bacteria,1TPGS@1239|Firmicutes,24882@186801|Clostridia,42HQ6@68295|Thermoanaerobacterales	186801|Clostridia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit	ntpA	-	3.6.3.14,3.6.3.15	ko:K02117	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002,ko01000	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn
HKD2_k127_4110133_12	1230342.CTM_17751	1.217e-15	85.0	COG1390@1|root,COG1390@2|Bacteria,1VFFG@1239|Firmicutes,24PH0@186801|Clostridia,36MAV@31979|Clostridiaceae	186801|Clostridia	C	COG1390 Archaeal vacuolar-type H -ATPase subunit E	-	-	-	-	-	-	-	-	-	-	-	-	vATP-synt_E
HKD2_k127_4110133_11	1150474.JQJI01000025_gene1668	1.501e-30	124.0	COG1436@1|root,COG1436@2|Bacteria,2GDJA@200918|Thermotogae	200918|Thermotogae	C	ATP synthase (F/14-kDa) subunit	-	-	-	ko:K02122	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_F
HKD2_k127_4110133_10	1209989.TepiRe1_0560	5.689e-34	135.0	COG0636@1|root,COG0636@2|Bacteria,1VAGE@1239|Firmicutes,24RB6@186801|Clostridia,42IFG@68295|Thermoanaerobacterales	186801|Clostridia	U	ATP synthase subunit C	-	-	-	ko:K02124	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_C
HKD2_k127_4110133_3	555079.Toce_1720	9.486e-187	604.0	COG1269@1|root,COG1269@2|Bacteria,1TPTE@1239|Firmicutes,249YV@186801|Clostridia,42I3J@68295|Thermoanaerobacterales	186801|Clostridia	U	V-type ATPase 116kDa subunit family	ntpI	-	-	ko:K02123	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	V_ATPase_I
HKD2_k127_4110133_7	1209989.TepiRe1_0558	2.794e-99	334.0	COG1527@1|root,COG1527@2|Bacteria,1U1QE@1239|Firmicutes,24A4E@186801|Clostridia,42HXX@68295|Thermoanaerobacterales	186801|Clostridia	C	ATP synthase (C/AC39) subunit	ntpC	-	-	ko:K02119	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	vATP-synt_AC39
HKD2_k127_4110133_6	1304284.L21TH_1105	4.559e-138	456.0	COG1315@1|root,COG1315@2|Bacteria,1TR7W@1239|Firmicutes,24D54@186801|Clostridia,36F9H@31979|Clostridiaceae	186801|Clostridia	L	Pfam:DUF342	-	-	-	ko:K09749	-	-	-	-	ko00000	-	-	-	FapA
HKD2_k127_4110133_5	1304284.L21TH_1104	6.857e-160	523.0	28JR8@1|root,2Z9GX@2|Bacteria,1TQPC@1239|Firmicutes,24B8N@186801|Clostridia,36HE8@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	GAF_3
HKD2_k127_4110133_8	1304880.JAGB01000003_gene1146	1.58e-91	306.0	COG1011@1|root,COG1011@2|Bacteria,1UIE8@1239|Firmicutes,24I5V@186801|Clostridia	186801|Clostridia	S	PFAM Haloacid dehalogenase domain protein hydrolase	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2
HKD2_k127_4110133_2	1304880.JAGB01000002_gene2169	2.968e-200	630.0	COG0162@1|root,COG0162@2|Bacteria,1TPGN@1239|Firmicutes,247QC@186801|Clostridia	186801|Clostridia	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	-	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	S4,tRNA-synt_1b
HKD2_k127_411562_8	1304284.L21TH_0535	2.068e-24	104.0	COG3457@1|root,COG3457@2|Bacteria,1TNYJ@1239|Firmicutes,248MC@186801|Clostridia,36ESB@31979|Clostridiaceae	186801|Clostridia	E	Alanine racemase, N-terminal domain	-	-	5.1.1.12	ko:K21898	ko00472,map00472	-	R00672	RC00302	ko00000,ko00001,ko01000	-	-	-	Ala_racemase_N
HKD2_k127_411562_4	1304284.L21TH_0535	6.458e-118	387.0	COG3457@1|root,COG3457@2|Bacteria,1TNYJ@1239|Firmicutes,248MC@186801|Clostridia,36ESB@31979|Clostridiaceae	186801|Clostridia	E	Alanine racemase, N-terminal domain	-	-	5.1.1.12	ko:K21898	ko00472,map00472	-	R00672	RC00302	ko00000,ko00001,ko01000	-	-	-	Ala_racemase_N
HKD2_k127_411562_2	469381.Dpep_0856	2.039e-218	684.0	COG0849@1|root,COG0849@2|Bacteria,3TC6B@508458|Synergistetes	508458|Synergistetes	D	MutL protein	-	-	-	-	-	-	-	-	-	-	-	-	MutL
HKD2_k127_411562_0	469381.Dpep_0857	0.0	1298.0	COG5012@1|root,COG5012@2|Bacteria	2|Bacteria	T	cobalamin binding	oraE	-	5.4.3.5	ko:K17898	ko00472,map00472	-	R02461	RC00719	ko00000,ko00001,ko01000	-	-	-	B12-binding,Lys-AminoMut_A,OAM_dimer
HKD2_k127_411562_5	469381.Dpep_0858	7.235e-51	182.0	2DMJP@1|root,32S0N@2|Bacteria	2|Bacteria	S	D-ornithine 4,5-aminomutase alpha-subunit	oraS	-	5.4.3.5	ko:K17899	ko00472,map00472	-	R02461	RC00719	ko00000,ko00001,ko01000	-	-	-	OAM_alpha
HKD2_k127_411562_1	857293.CAAU_2574	2.874e-240	749.0	COG0031@1|root,COG0031@2|Bacteria,1UI2J@1239|Firmicutes,25EB5@186801|Clostridia,36UJ3@31979|Clostridiaceae	186801|Clostridia	E	Pyridoxal-phosphate dependent enzyme	-	-	2.3.1.263	ko:K21400	-	-	-	-	ko00000,ko01000	-	-	-	PALP
HKD2_k127_411562_7	1511.CLOST_1293	1.483e-37	143.0	2E6IF@1|root,3315M@2|Bacteria,1VAX0@1239|Firmicutes,24N55@186801|Clostridia	186801|Clostridia	-	-	ortA	GO:0006082,GO:0006520,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0071704,GO:1901564,GO:1901605	2.3.1.263	ko:K21399	-	-	-	-	ko00000,ko01000	-	-	-	-
HKD2_k127_411562_3	318464.IO99_14700	1.106e-186	587.0	COG3804@1|root,COG3804@2|Bacteria,1TRNF@1239|Firmicutes,249AS@186801|Clostridia,36FWB@31979|Clostridiaceae	186801|Clostridia	S	Dihydrodipicolinate reductase, N-terminus	ord	GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016638,GO:0016639,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0047530,GO:0055114,GO:0071704,GO:1901564,GO:1901605	1.4.1.12,1.4.1.26	ko:K21672	ko00310,ko00330,ko00472,map00310,map00330,map00472	-	R02825,R04200,R04201,R04687,R04688	RC00249,RC00790	ko00000,ko00001,ko01000	-	-	-	DapB_N
HKD2_k127_411562_6	1238184.CM001792_gene556	2.771e-40	154.0	COG1387@1|root,COG1387@2|Bacteria,1TRKS@1239|Firmicutes,4HC0G@91061|Bacilli,23IV1@182709|Oceanobacillus	91061|Bacilli	E	DNA polymerase alpha chain like domain	hisK	-	3.1.3.15	ko:K04486	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R03013	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PHP
HKD2_k127_4142681_6	1304880.JAGB01000002_gene2189	7.108e-65	232.0	COG1284@1|root,COG1284@2|Bacteria,1TR9J@1239|Firmicutes,24BGW@186801|Clostridia	186801|Clostridia	S	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	DUF2179,YitT_membrane
HKD2_k127_4142681_5	1291050.JAGE01000001_gene1244	2.184e-66	234.0	COG1922@1|root,COG1922@2|Bacteria,1V3QV@1239|Firmicutes,24AQ3@186801|Clostridia,3WJNB@541000|Ruminococcaceae	186801|Clostridia	M	Catalyzes the conversion of GlcNAc-PP-undecaprenol into ManNAc-GlcNAc-PP-undecaprenol, the first committed lipid intermediate in the de novo synthesis of teichoic acid	tagA	-	2.4.1.187	ko:K05946	ko05111,map05111	-	-	-	ko00000,ko00001,ko01000,ko01003	-	GT26	-	Glyco_tran_WecB,PS_pyruv_trans
HKD2_k127_4142681_0	697281.Mahau_0332	1.939e-169	541.0	COG0766@1|root,COG0766@2|Bacteria,1TPAU@1239|Firmicutes,2488W@186801|Clostridia,42EUT@68295|Thermoanaerobacterales	186801|Clostridia	M	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine	murA	-	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase
HKD2_k127_4142681_4	97138.C820_01130	4.878e-69	258.0	COG4124@1|root,COG4124@2|Bacteria,1UY1U@1239|Firmicutes,24J6Z@186801|Clostridia	186801|Clostridia	G	Belongs to the glycosyl hydrolase 26 family	-	-	-	-	-	-	-	-	-	-	-	-	Cu_amine_oxidN1,Glyco_hydro_26
HKD2_k127_4142681_2	97138.C820_02749	4.591e-107	359.0	COG0438@1|root,COG2327@1|root,COG0438@2|Bacteria,COG2327@2|Bacteria,1TPTI@1239|Firmicutes,248QN@186801|Clostridia,36HQ2@31979|Clostridiaceae	186801|Clostridia	M	Polysaccharide pyruvyl transferase	csaB	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1,PS_pyruv_trans
HKD2_k127_4142681_1	203119.Cthe_2702	3.618e-125	410.0	COG0438@1|root,COG2327@1|root,COG0438@2|Bacteria,COG2327@2|Bacteria,1TPTI@1239|Firmicutes,248QN@186801|Clostridia,3WHHB@541000|Ruminococcaceae	186801|Clostridia	M	Polysaccharide pyruvyl transferase	csaB	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1,PS_pyruv_trans
HKD2_k127_4142681_11	1033744.CAEL01000013_gene920	1.384e-13	77.0	2EAHI@1|root,32UCY@2|Bacteria,1VBA6@1239|Firmicutes,24PDY@186801|Clostridia	186801|Clostridia	S	Domain of unknown function (DUF4330)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4330
HKD2_k127_4142681_10	97138.C820_02751	3.413e-15	82.0	2BE9X@1|root,3280X@2|Bacteria,1UTY7@1239|Firmicutes,254UB@186801|Clostridia	186801|Clostridia	S	Domain of unknown function (DUF4330)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4330
HKD2_k127_4142681_3	97138.C820_02752	8.377e-85	293.0	COG0438@1|root,COG0438@2|Bacteria,1UHSF@1239|Firmicutes,25EAY@186801|Clostridia,36F2W@31979|Clostridiaceae	186801|Clostridia	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
HKD2_k127_4142681_7	1378168.N510_01514	4.546e-64	243.0	COG3307@1|root,COG3307@2|Bacteria,1TQGY@1239|Firmicutes	1239|Firmicutes	M	O-Antigen Polymerase	-	-	-	ko:K18814	-	-	-	-	ko00000,ko02000	9.B.67.1	-	-	Wzy_C
HKD2_k127_4142681_8	1031288.AXAA01000022_gene1554	1.496e-55	197.0	COG2337@1|root,COG2337@2|Bacteria,1V6DK@1239|Firmicutes,24JE1@186801|Clostridia,36IPB@31979|Clostridiaceae	186801|Clostridia	L	Toxic component of a toxin-antitoxin (TA) module	ndoA	-	-	ko:K07171	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PemK_toxin
HKD2_k127_4144304_7	2325.TKV_c15230	3.229e-73	253.0	COG0704@1|root,COG0704@2|Bacteria,1URN3@1239|Firmicutes,24FTM@186801|Clostridia,42FW2@68295|Thermoanaerobacterales	186801|Clostridia	P	Plays a role in the regulation of phosphate uptake	phoU	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009892,GO:0010563,GO:0010966,GO:0019220,GO:0019222,GO:0031323,GO:0031324,GO:0032879,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0042802,GO:0042803,GO:0043269,GO:0043271,GO:0044070,GO:0044424,GO:0044464,GO:0045936,GO:0046983,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051049,GO:0051051,GO:0051174,GO:0065007,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186	-	ko:K02039	-	-	-	-	ko00000	-	-	-	PhoU
HKD2_k127_4144304_1	272562.CA_C1708	1.097e-127	411.0	COG1117@1|root,COG1117@2|Bacteria,1TP1M@1239|Firmicutes,247RD@186801|Clostridia,36DJ4@31979|Clostridiaceae	186801|Clostridia	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	pstB	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
HKD2_k127_4144304_3	351627.Csac_1612	5.052e-106	351.0	COG0581@1|root,COG0581@2|Bacteria,1TP74@1239|Firmicutes,248C4@186801|Clostridia,42F9B@68295|Thermoanaerobacterales	186801|Clostridia	P	PFAM binding-protein-dependent transport systems inner membrane component	pstA	-	-	ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
HKD2_k127_4144304_2	349161.Dred_2105	6.79e-113	370.0	COG0573@1|root,COG0573@2|Bacteria,1TSPP@1239|Firmicutes,249KQ@186801|Clostridia,2604V@186807|Peptococcaceae	186801|Clostridia	P	probably responsible for the translocation of the substrate across the membrane	pstC	-	-	ko:K02037	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
HKD2_k127_4144304_6	608506.COB47_1371	2.897e-78	272.0	COG0226@1|root,COG0226@2|Bacteria,1TQ5X@1239|Firmicutes,248QU@186801|Clostridia,42EPR@68295|Thermoanaerobacterales	186801|Clostridia	P	PFAM extracellular solute-binding protein family 1	pstS	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
HKD2_k127_4144304_0	1408422.JHYF01000002_gene2539	3.595e-148	488.0	COG5002@1|root,COG5002@2|Bacteria,1TQ1H@1239|Firmicutes,247VG@186801|Clostridia,36DIS@31979|Clostridiaceae	186801|Clostridia	T	Histidine kinase	phoR	-	2.7.13.3	ko:K07636	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4,sCache_like
HKD2_k127_4144304_4	340099.Teth39_0825	1.01e-84	287.0	COG0745@1|root,COG0745@2|Bacteria,1TPWS@1239|Firmicutes,25AZ2@186801|Clostridia,42JDU@68295|Thermoanaerobacterales	186801|Clostridia	K	Response regulator receiver	phoP	-	-	ko:K02483,ko:K07658,ko:K07668	ko02020,map02020	M00434,M00459	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
HKD2_k127_4144304_5	742723.HMPREF9477_00497	2.86e-81	278.0	COG1496@1|root,COG1496@2|Bacteria,1TS34@1239|Firmicutes,248TD@186801|Clostridia,27IR7@186928|unclassified Lachnospiraceae	186801|Clostridia	L	Multi-copper polyphenol oxidoreductase laccase	yfiH	-	-	ko:K05810	-	-	-	-	ko00000,ko01000	-	-	-	Cu-oxidase_4
HKD2_k127_4163190_0	1031288.AXAA01000021_gene2418	2.95e-212	668.0	COG3845@1|root,COG3845@2|Bacteria,1UYQA@1239|Firmicutes,24XN8@186801|Clostridia,36UI0@31979|Clostridiaceae	186801|Clostridia	S	ABC transporter	yufO	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
HKD2_k127_4163190_1	373903.Hore_08790	2.072e-95	324.0	COG4603@1|root,COG4603@2|Bacteria,1TP1F@1239|Firmicutes,2494C@186801|Clostridia,3WAFN@53433|Halanaerobiales	186801|Clostridia	U	PFAM Branched-chain amino acid transport system permease component	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
HKD2_k127_41846_3	555079.Toce_1750	1.395e-15	78.0	COG0605@1|root,COG0605@2|Bacteria,1TPXT@1239|Firmicutes,24HDS@186801|Clostridia,42H7P@68295|Thermoanaerobacterales	186801|Clostridia	C	Destroys radicals which are normally produced within the cells and which are toxic to biological systems	sodF	-	1.15.1.1	ko:K04564	ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016	-	-	-	ko00000,ko00001,ko01000	-	-	-	Sod_Fe_C,Sod_Fe_N
HKD2_k127_41846_1	536227.CcarbDRAFT_5047	1.246e-140	469.0	COG1368@1|root,COG1368@2|Bacteria,1TRMA@1239|Firmicutes,2480C@186801|Clostridia,36DDX@31979|Clostridiaceae	186801|Clostridia	M	Phosphoglycerol transferase and related proteins,, alkaline phosphatase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
HKD2_k127_41846_0	203119.Cthe_3196	8.034e-162	521.0	COG4198@1|root,COG4198@2|Bacteria,1TQ52@1239|Firmicutes,24985@186801|Clostridia,3WGM6@541000|Ruminococcaceae	186801|Clostridia	S	Protein of unknown function (DUF1015)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1015
HKD2_k127_41846_2	1408422.JHYF01000016_gene122	6.074e-82	275.0	COG0111@1|root,COG0111@2|Bacteria,1V410@1239|Firmicutes,248H9@186801|Clostridia,36DCU@31979|Clostridiaceae	186801|Clostridia	EH	D-isomer specific 2-hydroxyacid dehydrogenase	serA	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
HKD2_k127_41889_2	1262449.CP6013_1583	1.141e-39	151.0	COG0264@1|root,COG0264@2|Bacteria,1VGFM@1239|Firmicutes,25HJI@186801|Clostridia,36VB3@31979|Clostridiaceae	186801|Clostridia	J	Domain of unknown function (DUF4342)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4342
HKD2_k127_41889_5	1499684.CCNP01000025_gene3628	0.0006429	45.0	29UBB@1|root,30FMK@2|Bacteria,1UE8I@1239|Firmicutes,24P8N@186801|Clostridia,36KZQ@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_41889_1	86416.Clopa_3818	1.314e-82	277.0	COG2249@1|root,COG2249@2|Bacteria,1V4UF@1239|Firmicutes,24Q36@186801|Clostridia	186801|Clostridia	S	NADPH-quinone reductase (modulator of drug activity B)	-	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_2
HKD2_k127_41889_4	1033737.CAEV01000001_gene2332	4.68e-17	89.0	COG0645@1|root,COG0645@2|Bacteria	2|Bacteria	S	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_33
HKD2_k127_41889_0	1304284.L21TH_0557	2.144e-88	295.0	COG4869@1|root,COG4869@2|Bacteria,1V242@1239|Firmicutes,24816@186801|Clostridia,36E22@31979|Clostridiaceae	186801|Clostridia	Q	Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate	pduL	-	2.3.1.8	ko:K15024	ko00430,ko00620,ko00640,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00720,map01100,map01120,map01200	M00579	R00230,R00921	RC00004,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000	-	-	-	Cob_adeno_trans,PTAC
HKD2_k127_4200556_1	1499689.CCNN01000014_gene3261	2.586e-120	391.0	COG1234@1|root,COG1234@2|Bacteria,1TRGP@1239|Firmicutes,248EQ@186801|Clostridia,36E2R@31979|Clostridiaceae	186801|Clostridia	S	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA	rnz	-	3.1.26.11	ko:K00784	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Lactamase_B_2
HKD2_k127_4200556_0	1211817.CCAT010000062_gene3983	1.408e-189	604.0	COG1233@1|root,COG1233@2|Bacteria,1TS4A@1239|Firmicutes,249K1@186801|Clostridia,36G4Z@31979|Clostridiaceae	186801|Clostridia	Q	Flavin containing amine oxidoreductase	crtI	-	1.3.99.26,1.3.99.28,1.3.99.29,1.3.99.31	ko:K10027	ko00906,ko01100,ko01110,map00906,map01100,map01110	-	R04787,R04798,R04800,R09691,R09692	RC01214,RC02088,RC02605	ko00000,ko00001,ko01000	-	-	-	Amino_oxidase
HKD2_k127_4200556_2	1408422.JHYF01000009_gene2187	4.469e-13	69.0	COG3191@1|root,COG3191@2|Bacteria,1TQHA@1239|Firmicutes,24CV6@186801|Clostridia,36F1R@31979|Clostridiaceae	186801|Clostridia	EQ	Peptidase family S58	dmpA	-	3.4.11.19	ko:K01266	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S58
HKD2_k127_4214855_5	1033743.CAES01000096_gene2720	1.018e-20	97.0	COG1737@1|root,COG1737@2|Bacteria,1TP7H@1239|Firmicutes,4HC98@91061|Bacilli,274GK@186822|Paenibacillaceae	91061|Bacilli	K	Helix-turn-helix domain, rpiR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_6,SIS
HKD2_k127_4214855_0	37659.JNLN01000001_gene1602	1.96e-140	466.0	COG1164@1|root,COG1164@2|Bacteria,1TQ5W@1239|Firmicutes,25CE1@186801|Clostridia,36FKN@31979|Clostridiaceae	186801|Clostridia	E	Oligoendopeptidase, pepF M3 family	pepF	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M3,Peptidase_M3_N
HKD2_k127_4214855_9	1121935.AQXX01000142_gene2266	5.545e-07	54.0	2DSB0@1|root,33FBC@2|Bacteria,1NGBC@1224|Proteobacteria,1SH3C@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4214855_10	935836.JAEL01000201_gene4586	1.449e-06	50.0	2AWWM@1|root,31NU5@2|Bacteria,1TZQ8@1239|Firmicutes,4II4F@91061|Bacilli,1ZJ4J@1386|Bacillus	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4214855_8	1087481.AGFX01000013_gene3067	1.722e-07	53.0	2BKI8@1|root,32EZF@2|Bacteria,1TZNM@1239|Firmicutes,4I8XU@91061|Bacilli,270PJ@186822|Paenibacillaceae	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4214855_4	1123075.AUDP01000003_gene632	1.303e-46	174.0	COG0127@1|root,COG0127@2|Bacteria,1V6RN@1239|Firmicutes,249GK@186801|Clostridia,3WIUM@541000|Ruminococcaceae	186801|Clostridia	F	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions	rdgB	-	3.6.1.66	ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000	-	-	-	Ham1p_like
HKD2_k127_4214855_1	580331.Thit_0596	7.036e-104	343.0	COG0689@1|root,COG0689@2|Bacteria,1TQM3@1239|Firmicutes,25E5P@186801|Clostridia,42F6J@68295|Thermoanaerobacterales	186801|Clostridia	J	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates	rph	-	2.7.7.56,3.6.1.66	ko:K00989,ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000,ko03016	-	-	-	Ham1p_like,RNase_PH,RNase_PH_C
HKD2_k127_4214855_3	1347392.CCEZ01000023_gene807	4.81e-53	200.0	COG5401@1|root,COG5401@2|Bacteria,1TPQD@1239|Firmicutes,248VN@186801|Clostridia,36F16@31979|Clostridiaceae	186801|Clostridia	S	Sporulation and spore germination	-	-	-	ko:K06298	-	-	-	-	ko00000	-	-	-	Germane
HKD2_k127_4214855_2	1209989.TepiRe1_0654	2.449e-71	270.0	COG0860@1|root,COG0860@2|Bacteria,1UYPW@1239|Firmicutes,24BHU@186801|Clostridia,42F03@68295|Thermoanaerobacterales	186801|Clostridia	M	PFAM cell wall hydrolase autolysin	lytC	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	AMIN,Amidase_3,Cu_amine_oxidN1,SH3_3
HKD2_k127_4234066_4	755731.Clo1100_1835	5.104e-24	103.0	COG2608@1|root,COG2836@1|root,COG4633@1|root,COG2608@2|Bacteria,COG2836@2|Bacteria,COG4633@2|Bacteria,1TQ02@1239|Firmicutes,249HC@186801|Clostridia,36DCI@31979|Clostridiaceae	186801|Clostridia	P	Heavy metal transport detoxification protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupredoxin_1,DsbD_2,HMA
HKD2_k127_4234066_7	1033733.CAEK01000001_gene231	3.024e-05	47.0	2BYNT@1|root,2ZTRZ@2|Bacteria,1W1RV@1239|Firmicutes,2563I@186801|Clostridia,22I0Z@1570339|Peptoniphilaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4234066_1	580331.Thit_0981	2.364e-84	285.0	COG0745@1|root,COG0745@2|Bacteria,1U3FH@1239|Firmicutes,248BR@186801|Clostridia,42G5A@68295|Thermoanaerobacterales	186801|Clostridia	K	Two component transcriptional regulator, winged helix family	-	-	-	ko:K02483,ko:K18344	ko01502,ko02020,map01502,map02020	M00651,M00656	-	-	ko00000,ko00001,ko00002,ko01504,ko02022	-	-	-	Response_reg,Trans_reg_C
HKD2_k127_4234066_0	398512.JQKC01000008_gene938	2.98e-147	479.0	COG5002@1|root,COG5002@2|Bacteria,1TQ1H@1239|Firmicutes,247VG@186801|Clostridia,3WN3N@541000|Ruminococcaceae	186801|Clostridia	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
HKD2_k127_4234066_6	1294142.CINTURNW_3874	7.434e-06	53.0	2FFKY@1|root,347IC@2|Bacteria,1VYIW@1239|Firmicutes,24Q9U@186801|Clostridia,36MB1@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4234066_5	1304880.JAGB01000001_gene316	1.471e-22	97.0	2DS93@1|root,33F25@2|Bacteria,1VKBP@1239|Firmicutes,24RSQ@186801|Clostridia	186801|Clostridia	S	Domain of Unknown Function (DUF1540)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1540
HKD2_k127_4234066_3	1385511.N783_07905	9.078e-25	107.0	COG1145@1|root,32SB1@2|Bacteria,1V6N0@1239|Firmicutes,4HIWV@91061|Bacilli,2YANU@289201|Pontibacillus	91061|Bacilli	C	Domain of Unknown Function (DUF326)	-	-	-	-	-	-	-	-	-	-	-	-	DUF326
HKD2_k127_4234066_2	509191.AEDB02000074_gene1748	5.708e-25	109.0	COG0531@1|root,COG0531@2|Bacteria,1UK0A@1239|Firmicutes,24FV5@186801|Clostridia,3WSM4@541000|Ruminococcaceae	186801|Clostridia	E	Spore germination protein	-	-	-	ko:K06296	-	-	-	-	ko00000,ko02000	2.A.3.9.3	-	-	Spore_permease
HKD2_k127_425701_2	509191.AEDB02000018_gene223	3.912e-12	66.0	COG4213@1|root,COG4213@2|Bacteria,1TR3Q@1239|Firmicutes,2482X@186801|Clostridia,3WN3D@541000|Ruminococcaceae	186801|Clostridia	G	Periplasmic binding protein domain	-	-	-	ko:K10546	ko02010,map02010	M00216	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.5	-	-	Peripla_BP_4
HKD2_k127_425701_0	1031288.AXAA01000003_gene1730	6.63e-257	799.0	COG1129@1|root,COG1129@2|Bacteria,1TP6I@1239|Firmicutes,247II@186801|Clostridia,36DME@31979|Clostridiaceae	186801|Clostridia	P	import. Responsible for energy coupling to the transport system	-	-	3.6.3.17	ko:K10548	ko02010,map02010	M00216	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.5	-	-	ABC_tran
HKD2_k127_425701_1	857293.CAAU_0338	7.48e-178	563.0	COG4214@1|root,COG4214@2|Bacteria,1VU1F@1239|Firmicutes,24XS9@186801|Clostridia,36UQN@31979|Clostridiaceae	186801|Clostridia	G	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K10547	ko02010,map02010	M00216	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.5	-	-	BPD_transp_2
HKD2_k127_4260264_2	1321778.HMPREF1982_02896	4.853e-52	185.0	COG3382@1|root,COG3382@2|Bacteria,1TT38@1239|Firmicutes,248VG@186801|Clostridia,26A27@186813|unclassified Clostridiales	186801|Clostridia	S	B3/4 domain	-	-	-	-	-	-	-	-	-	-	-	-	B3_4
HKD2_k127_4260264_1	646529.Desaci_2459	4.174e-61	214.0	COG0242@1|root,COG0242@2|Bacteria,1V41Q@1239|Firmicutes,24I9S@186801|Clostridia	186801|Clostridia	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions	-	-	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	Pep_deformylase
HKD2_k127_4260264_0	720554.Clocl_1494	7.493e-71	244.0	COG2519@1|root,COG2519@2|Bacteria,1V6VU@1239|Firmicutes,24JEE@186801|Clostridia,3WIXW@541000|Ruminococcaceae	186801|Clostridia	J	Putative rRNA methylase	-	-	-	-	-	-	-	-	-	-	-	-	rRNA_methylase
HKD2_k127_4260264_3	195103.CPF_1959	2.053e-33	132.0	COG0792@1|root,COG0792@2|Bacteria,1VFHQ@1239|Firmicutes,24QNK@186801|Clostridia,36MV2@31979|Clostridiaceae	186801|Clostridia	L	Belongs to the UPF0102 family	-	-	-	ko:K07460	-	-	-	-	ko00000	-	-	-	UPF0102
HKD2_k127_4260264_5	509191.AEDB02000088_gene2680	5.188e-21	94.0	COG2257@1|root,COG2257@2|Bacteria,1VF4R@1239|Firmicutes,24QSW@186801|Clostridia,3WKB2@541000|Ruminococcaceae	186801|Clostridia	S	FlhB HrpN YscU SpaS Family	flhB1	-	-	ko:K04061	-	-	-	-	ko00000,ko02044	-	-	-	Bac_export_2
HKD2_k127_4260264_4	203119.Cthe_0760	1.859e-21	103.0	COG1196@1|root,COG1196@2|Bacteria,1V92J@1239|Firmicutes,25ERI@186801|Clostridia,3WNGT@541000|Ruminococcaceae	186801|Clostridia	N	Flagellar hook-length control protein FliK	-	-	-	-	-	-	-	-	-	-	-	-	Flg_hook
HKD2_k127_428236_1	509191.AEDB02000018_gene270	2.234e-165	523.0	COG1131@1|root,COG1131@2|Bacteria,1TQHS@1239|Firmicutes,24941@186801|Clostridia,3WGCM@541000|Ruminococcaceae	186801|Clostridia	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD2_k127_428236_5	398512.JQKC01000043_gene4246	2.512e-77	263.0	COG1309@1|root,COG1309@2|Bacteria,1V4D3@1239|Firmicutes,25B48@186801|Clostridia,3WS5Q@541000|Ruminococcaceae	186801|Clostridia	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
HKD2_k127_428236_2	1294142.CINTURNW_1213	8.568e-149	480.0	COG0491@1|root,COG2119@1|root,COG0491@2|Bacteria,COG2119@2|Bacteria,1UFX2@1239|Firmicutes,24DHF@186801|Clostridia,36HDQ@31979|Clostridiaceae	186801|Clostridia	S	Uncharacterized protein family UPF0016	-	-	-	-	-	-	-	-	-	-	-	-	UPF0016
HKD2_k127_428236_0	509191.AEDB02000109_gene4976	1.346e-228	716.0	COG0513@1|root,COG0513@2|Bacteria,1TPAP@1239|Firmicutes,247IT@186801|Clostridia,3WGD9@541000|Ruminococcaceae	186801|Clostridia	L	Belongs to the DEAD box helicase family	-	-	3.6.4.13	ko:K05592	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019	-	-	-	DEAD,DbpA,Helicase_C
HKD2_k127_428236_6	931626.Awo_c32310	1.407e-70	243.0	COG2220@1|root,COG2220@2|Bacteria,1TQR1@1239|Firmicutes,24H8J@186801|Clostridia,25ZD4@186806|Eubacteriaceae	186801|Clostridia	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_3
HKD2_k127_428236_3	545243.BAEV01000005_gene957	7.661e-112	363.0	COG0655@1|root,COG0655@2|Bacteria,1TT84@1239|Firmicutes,248W0@186801|Clostridia,36E3H@31979|Clostridiaceae	186801|Clostridia	S	NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
HKD2_k127_428236_9	272562.CA_C0750	6.293e-44	162.0	2BRA9@1|root,32K8T@2|Bacteria,1V7R0@1239|Firmicutes,24EUJ@186801|Clostridia,36DQU@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_428236_4	1487921.DP68_01970	5.336e-89	297.0	COG1309@1|root,COG1309@2|Bacteria,1V4J0@1239|Firmicutes,24XDH@186801|Clostridia,36PUZ@31979|Clostridiaceae	186801|Clostridia	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
HKD2_k127_428236_8	1487921.DP68_01965	8.724e-58	203.0	COG0346@1|root,COG0346@2|Bacteria,1V48E@1239|Firmicutes	1239|Firmicutes	E	COG0346 LactoylglutaTHIone lyase and related lyases	yurT	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HKD2_k127_428236_7	931626.Awo_c20530	1.552e-62	221.0	COG0778@1|root,COG0778@2|Bacteria,1V297@1239|Firmicutes,24FWY@186801|Clostridia,25YSV@186806|Eubacteriaceae	186801|Clostridia	C	Putative TM nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	TM1586_NiRdase
HKD2_k127_43403_5	428125.CLOLEP_02486	4.404e-24	105.0	COG0285@1|root,COG0285@2|Bacteria,1TPX5@1239|Firmicutes,247PC@186801|Clostridia,3WGH0@541000|Ruminococcaceae	186801|Clostridia	H	Belongs to the folylpolyglutamate synthase family	folC	-	6.3.2.12,6.3.2.17	ko:K11754	ko00790,ko01100,map00790,map01100	M00126,M00841	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	Mur_ligase_C,Mur_ligase_M
HKD2_k127_43403_0	1121423.JONT01000016_gene1160	4.906e-144	465.0	COG0012@1|root,COG0012@2|Bacteria,1TPRK@1239|Firmicutes,2482Z@186801|Clostridia,260HS@186807|Peptococcaceae	186801|Clostridia	J	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner	ychF	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,YchF-GTPase_C
HKD2_k127_43403_3	1410653.JHVC01000005_gene2522	2.525e-42	161.0	COG3432@1|root,COG3432@2|Bacteria,1V75P@1239|Firmicutes,24JAZ@186801|Clostridia,36IRW@31979|Clostridiaceae	186801|Clostridia	K	Domain of unknown function (DUF4364)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4364
HKD2_k127_43403_4	857293.CAAU_0466	2.949e-25	107.0	2DP0G@1|root,33014@2|Bacteria,1VGP0@1239|Firmicutes,24REU@186801|Clostridia	186801|Clostridia	S	Small, acid-soluble spore proteins, alpha/beta type	-	-	-	-	-	-	-	-	-	-	-	-	SASP
HKD2_k127_43403_6	941824.TCEL_00547	2.486e-11	66.0	2ER3A@1|root,33INX@2|Bacteria,1VNQX@1239|Firmicutes,24W9Z@186801|Clostridia,36TCJ@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_43403_1	1304284.L21TH_2507	1.921e-103	347.0	COG0726@1|root,COG0726@2|Bacteria,1TRUR@1239|Firmicutes,24D1N@186801|Clostridia,36H4R@31979|Clostridiaceae	186801|Clostridia	G	PFAM Polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
HKD2_k127_43403_2	926569.ANT_19770	2.583e-63	225.0	COG1073@1|root,COG1073@2|Bacteria,2G690@200795|Chloroflexi	200795|Chloroflexi	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_5
HKD2_k127_4355775_3	56780.SYN_01022	6.378e-09	60.0	COG1234@1|root,COG1234@2|Bacteria	2|Bacteria	L	tRNA 3'-trailer cleavage	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
HKD2_k127_4355775_2	1227349.C170_29103	1.694e-135	436.0	COG3711@1|root,COG3711@2|Bacteria,1TT5A@1239|Firmicutes,4HC5Y@91061|Bacilli,26QX5@186822|Paenibacillaceae	91061|Bacilli	K	antiterminator	-	-	-	ko:K03488	-	-	-	-	ko00000,ko03000	-	-	-	CAT_RBD,PRD
HKD2_k127_4355775_0	1227349.C170_29108	7.885e-268	836.0	COG1263@1|root,COG1264@1|root,COG2190@1|root,COG1263@2|Bacteria,COG1264@2|Bacteria,COG2190@2|Bacteria,1TP5X@1239|Firmicutes,4HA0I@91061|Bacilli,26QAW@186822|Paenibacillaceae	1239|Firmicutes	G	COG1264 Phosphotransferase system IIB components	-	-	-	-	-	-	-	-	-	-	-	-	PTS_EIIA_1,PTS_EIIB,PTS_EIIC
HKD2_k127_4355775_1	1227349.C170_29113	5.516e-151	479.0	COG2723@1|root,COG2723@2|Bacteria,1TP19@1239|Firmicutes,4HA1W@91061|Bacilli,26QRQ@186822|Paenibacillaceae	91061|Bacilli	G	Belongs to the glycosyl hydrolase 1 family	-	-	3.2.1.86	ko:K01223	ko00010,ko00500,map00010,map00500	-	R00839,R05133,R05134	RC00049,RC00171,RC00714	ko00000,ko00001,ko01000	-	GT1	-	Glyco_hydro_1
HKD2_k127_4368750_3	509191.AEDB02000100_gene4084	1.708e-41	158.0	COG4753@1|root,COG4753@2|Bacteria,1UJJ3@1239|Firmicutes,25F44@186801|Clostridia,3WP7C@541000|Ruminococcaceae	186801|Clostridia	T	cheY-homologous receiver domain	-	-	-	ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	Response_reg
HKD2_k127_4368750_1	1304284.L21TH_0157	1.735e-98	331.0	COG3872@1|root,COG3872@2|Bacteria,1TPBU@1239|Firmicutes,25C8E@186801|Clostridia,36FM3@31979|Clostridiaceae	186801|Clostridia	J	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif	prmC	-	-	-	-	-	-	-	-	-	-	-	DUF1385,MTS
HKD2_k127_4368750_2	509191.AEDB02000035_gene2139	7.004e-71	250.0	COG2890@1|root,COG2890@2|Bacteria,1TSMA@1239|Firmicutes,24838@186801|Clostridia,3WGK1@541000|Ruminococcaceae	186801|Clostridia	J	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif	prmC	-	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS,Methyltransf_31
HKD2_k127_4368750_0	903814.ELI_3616	1.553e-158	506.0	COG0216@1|root,COG0216@2|Bacteria,1TQ7V@1239|Firmicutes,248CN@186801|Clostridia,25V56@186806|Eubacteriaceae	186801|Clostridia	J	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA	prfA	-	-	ko:K02835	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
HKD2_k127_4373781_3	1487921.DP68_07125	6.041e-33	131.0	COG3705@1|root,COG3705@2|Bacteria,1TPZZ@1239|Firmicutes,248CB@186801|Clostridia,36DWG@31979|Clostridiaceae	186801|Clostridia	E	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine	hisZ	-	-	ko:K02502	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002	-	-	-	tRNA-synt_His
HKD2_k127_4373781_1	1487921.DP68_07120	4.051e-103	338.0	COG0040@1|root,COG0040@2|Bacteria,1TSVZ@1239|Firmicutes,249AR@186801|Clostridia,36FAD@31979|Clostridiaceae	186801|Clostridia	F	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity	hisG	-	2.4.2.17	ko:K00765,ko:K02502	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002,ko01000	-	-	-	HisG
HKD2_k127_4373781_0	1487921.DP68_07115	9.983e-210	659.0	COG0141@1|root,COG0141@2|Bacteria,1TPAW@1239|Firmicutes,248X8@186801|Clostridia,36EFR@31979|Clostridiaceae	186801|Clostridia	E	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine	hisD	-	1.1.1.23	ko:K00013	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01158,R01163,R03012	RC00099,RC00242,RC00463	ko00000,ko00001,ko00002,ko01000	-	-	-	Histidinol_dh
HKD2_k127_4373781_2	1487921.DP68_07110	8.525e-100	331.0	COG0079@1|root,COG0079@2|Bacteria,1TPUV@1239|Firmicutes,24837@186801|Clostridia,36DDS@31979|Clostridiaceae	186801|Clostridia	E	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily	hisC	GO:0003674,GO:0003824,GO:0008110,GO:0008483,GO:0016740,GO:0016769	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
HKD2_k127_4411087_2	293826.Amet_2470	1.229e-14	75.0	COG4122@1|root,COG4122@2|Bacteria,1UF4M@1239|Firmicutes,24B70@186801|Clostridia,36EFT@31979|Clostridiaceae	186801|Clostridia	S	O-methyltransferase	yrrM	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_3
HKD2_k127_4411087_1	1304284.L21TH_1847	6.272e-97	328.0	COG1559@1|root,COG1559@2|Bacteria,1TS48@1239|Firmicutes,2493B@186801|Clostridia,36FDF@31979|Clostridiaceae	186801|Clostridia	S	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation	mltG	-	-	ko:K07082	-	-	-	-	ko00000	-	-	-	YceG
HKD2_k127_4411087_0	398512.JQKC01000009_gene487	4.747e-151	482.0	COG1217@1|root,COG1217@2|Bacteria,1TQ5Y@1239|Firmicutes,248EB@186801|Clostridia,3WGEU@541000|Ruminococcaceae	186801|Clostridia	T	GTP-binding protein TypA	typA	-	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,EFG_II,GTP_EFTU,GTP_EFTU_D2
HKD2_k127_443695_0	509191.AEDB02000022_gene3080	7.435e-216	672.0	COG0369@1|root,COG1151@2|Bacteria,1TRSC@1239|Firmicutes,248HQ@186801|Clostridia,3WH69@541000|Ruminococcaceae	186801|Clostridia	C	TIGRFAM carbon-monoxide dehydrogenase, catalytic subunit	cooS	-	1.2.7.4	ko:K00198	ko00633,ko00680,ko00720,ko01120,ko01200,map00633,map00680,map00720,map01120,map01200	M00377	R07157,R08034	RC00250,RC02800	ko00000,ko00001,ko00002,ko01000	-	-	-	Prismane
HKD2_k127_443695_1	350688.Clos_2425	5.763e-84	284.0	COG2846@1|root,COG2846@2|Bacteria,1UYJV@1239|Firmicutes,24GZI@186801|Clostridia,36FII@31979|Clostridiaceae	186801|Clostridia	D	Di-iron-containing protein involved in the repair of iron-sulfur clusters	ric	-	-	ko:K07322	-	-	-	-	ko00000	-	-	-	Hemerythrin,ScdA_N
HKD2_k127_443695_2	1286171.EAL2_c02750	1.131e-42	164.0	COG2199@1|root,COG3706@2|Bacteria,1V9S3@1239|Firmicutes,24B6H@186801|Clostridia	186801|Clostridia	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
HKD2_k127_449067_0	755731.Clo1100_1061	3.246e-68	254.0	COG1657@1|root,COG1657@2|Bacteria,1V69S@1239|Firmicutes,24FFM@186801|Clostridia,36KYJ@31979|Clostridiaceae	186801|Clostridia	I	S-layer homology domain	-	-	-	-	-	-	-	-	-	-	-	-	Cu_amine_oxidN1,SLH
HKD2_k127_449067_1	768710.DesyoDRAFT_3294	1.67e-41	154.0	2EAM6@1|root,334PU@2|Bacteria,1VJV6@1239|Firmicutes,24T90@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_449067_2	865861.AZSU01000005_gene839	4.14e-40	150.0	COG4416@1|root,COG4416@2|Bacteria,1VEMD@1239|Firmicutes,24MRR@186801|Clostridia,36KSJ@31979|Clostridiaceae	186801|Clostridia	S	COG NOG18757 non supervised orthologous group	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_453010_0	398512.JQKC01000002_gene2003	2.826e-158	501.0	COG0055@1|root,COG0055@2|Bacteria,1TPGF@1239|Firmicutes,2489W@186801|Clostridia,3WGVH@541000|Ruminococcaceae	186801|Clostridia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits	atpD	-	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_N
HKD2_k127_453010_2	203119.Cthe_2609	6.187e-45	166.0	COG0355@1|root,COG0355@2|Bacteria,1VA89@1239|Firmicutes,24ND7@186801|Clostridia,3WJG7@541000|Ruminococcaceae	186801|Clostridia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpC	-	-	ko:K02114	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_DE,ATP-synt_DE_N
HKD2_k127_453010_1	335541.Swol_2172	3.132e-111	367.0	COG0477@1|root,COG2814@2|Bacteria	2|Bacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_1_like,Sugar_tr
HKD2_k127_4578818_1	865861.AZSU01000002_gene2464	4.962e-47	173.0	COG5001@1|root,COG5001@2|Bacteria,1TP8V@1239|Firmicutes,247PX@186801|Clostridia,36E1W@31979|Clostridiaceae	186801|Clostridia	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	ABC_sub_bind,EAL,GGDEF,HisKA_7TM,PAS_9,SBP_bac_3
HKD2_k127_4578818_2	1345695.CLSA_c33750	1.369e-05	49.0	29UPU@1|root,30G1J@2|Bacteria,1UF1D@1239|Firmicutes,24UKV@186801|Clostridia	186801|Clostridia	S	Spo0E like sporulation regulatory protein	-	-	-	-	-	-	-	-	-	-	-	-	SpoOE-like
HKD2_k127_4578818_0	666686.B1NLA3E_17985	1.672e-136	437.0	COG0789@1|root,COG0789@2|Bacteria,1TS6Z@1239|Firmicutes,4HCVW@91061|Bacilli,1ZBMT@1386|Bacillus	91061|Bacilli	K	transcriptional	mta	-	-	-	-	-	-	-	-	-	-	-	MerR_1,TipAS
HKD2_k127_4613418_8	756499.Desde_0991	3.369e-19	86.0	COG0789@1|root,COG0789@2|Bacteria,1TS6Z@1239|Firmicutes,24BUT@186801|Clostridia,25ZZG@186807|Peptococcaceae	186801|Clostridia	K	MerR, DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	MerR_1,TipAS
HKD2_k127_4613418_3	431943.CKL_1611	6.066e-60	213.0	COG1595@1|root,COG1595@2|Bacteria,1V3H2@1239|Firmicutes,24JJ9@186801|Clostridia	186801|Clostridia	K	RNA polymerase sigma factor, sigma-70 family	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD2_k127_4613418_0	203119.Cthe_1807	8.755e-197	628.0	COG2834@1|root,COG2834@2|Bacteria,1UB6P@1239|Firmicutes,24DTV@186801|Clostridia	186801|Clostridia	M	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)	-	-	-	-	-	-	-	-	-	-	-	-	MucB_RseB
HKD2_k127_4613418_4	1094508.Tsac_2381	1.683e-40	165.0	COG0586@1|root,COG0586@2|Bacteria,1V8A4@1239|Firmicutes,25BNI@186801|Clostridia	186801|Clostridia	S	PFAM SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
HKD2_k127_4613418_6	1449126.JQKL01000068_gene2107	7.214e-33	142.0	COG0671@1|root,COG1238@1|root,COG0671@2|Bacteria,COG1238@2|Bacteria,1VF2U@1239|Firmicutes,24D98@186801|Clostridia,26C27@186813|unclassified Clostridiales	186801|Clostridia	I	Acid phosphatase homologues	-	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2,SNARE_assoc
HKD2_k127_4613418_1	857293.CAAU_2167	6.134e-187	598.0	COG0728@1|root,COG0728@2|Bacteria,1TPFI@1239|Firmicutes,247N3@186801|Clostridia,36FH2@31979|Clostridiaceae	186801|Clostridia	S	Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane	murJ	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN,Polysacc_synt_C
HKD2_k127_4613418_5	1286171.EAL2_c09890	3.426e-33	134.0	COG1633@1|root,COG1633@2|Bacteria,1VAB8@1239|Firmicutes,24SM6@186801|Clostridia	186801|Clostridia	S	Rubrerythrin	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
HKD2_k127_4613418_9	398512.JQKC01000013_gene1394	3.975e-17	89.0	2EDKH@1|root,337GC@2|Bacteria,1VHKT@1239|Firmicutes,24TFS@186801|Clostridia,3WQ9G@541000|Ruminococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4613418_2	1444309.JAQG01000157_gene3307	6.99e-74	252.0	COG1670@1|root,COG1670@2|Bacteria,1V49W@1239|Firmicutes,4HHAP@91061|Bacilli,276B9@186822|Paenibacillaceae	91061|Bacilli	J	Acetyltransferase (GNAT) domain	yjcK	-	2.3.1.128	ko:K03790	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_3
HKD2_k127_4613418_7	720554.Clocl_2900	1.354e-24	108.0	COG3714@1|root,COG3714@2|Bacteria,1URFW@1239|Firmicutes,25M2P@186801|Clostridia,3WP6S@541000|Ruminococcaceae	186801|Clostridia	S	YhhN family	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4628533_4	755731.Clo1100_1786	4.228e-108	353.0	COG1432@1|root,COG1432@2|Bacteria,1TTAC@1239|Firmicutes,249NE@186801|Clostridia,36DIB@31979|Clostridiaceae	186801|Clostridia	S	NYN domain	-	-	-	-	-	-	-	-	-	-	-	-	NYN,OST-HTH
HKD2_k127_4628533_5	1329516.JPST01000055_gene850	3.716e-33	138.0	COG3393@1|root,COG3393@2|Bacteria,1UFJG@1239|Firmicutes,4HGNR@91061|Bacilli,27CWV@186824|Thermoactinomycetaceae	91061|Bacilli	S	GNAT acetyltransferase	-	-	-	ko:K06976	-	-	-	-	ko00000	-	-	-	Acetyltransf_10,Acetyltransf_9,GNAT_acetyltran
HKD2_k127_4628533_0	1321778.HMPREF1982_01272	1.281e-160	514.0	COG0477@1|root,COG0477@2|Bacteria,1TTC8@1239|Firmicutes,24E7T@186801|Clostridia	186801|Clostridia	EGP	Major Facilitator Superfamily	-	-	-	ko:K08222	-	-	-	-	ko00000,ko02000	2.A.1.33	-	-	MFS_1
HKD2_k127_4628533_2	484770.UFO1_0793	9.971e-130	426.0	COG2855@1|root,COG2855@2|Bacteria,1TQYA@1239|Firmicutes,4H31V@909932|Negativicutes	909932|Negativicutes	S	Conserved hypothetical protein 698	yeiH	-	-	-	-	-	-	-	-	-	-	-	Cons_hypoth698
HKD2_k127_4628533_1	1230342.CTM_01679	1.109e-159	511.0	COG3170@1|root,COG3170@2|Bacteria,1TR7V@1239|Firmicutes,247XU@186801|Clostridia,36E8Q@31979|Clostridiaceae	186801|Clostridia	NU	Putative amidase domain	-	-	-	-	-	-	-	-	-	-	-	-	Amidase_6
HKD2_k127_4628533_3	1487921.DP68_16975	1.501e-108	360.0	COG0791@1|root,COG0791@2|Bacteria,1UZC6@1239|Firmicutes,247PE@186801|Clostridia,36E6P@31979|Clostridiaceae	186801|Clostridia	M	D-alanyl-D-alanine carboxypeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M15_4
HKD2_k127_4628533_6	1195236.CTER_0140	1.248e-22	97.0	COG5002@1|root,COG5002@2|Bacteria,1TQ1H@1239|Firmicutes,247VG@186801|Clostridia,3WSQQ@541000|Ruminococcaceae	186801|Clostridia	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
HKD2_k127_470181_0	1499967.BAYZ01000080_gene897	8.427e-93	315.0	COG0701@1|root,COG0701@2|Bacteria	2|Bacteria	S	Predicted permease	-	-	-	ko:K07089	-	-	-	-	ko00000	-	-	-	ArsP_1
HKD2_k127_470181_1	1291050.JAGE01000002_gene3633	4.656e-39	148.0	COG0640@1|root,COG0640@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	-	-	5.99.1.3	ko:K02470,ko:K03892	-	-	-	-	ko00000,ko01000,ko03000,ko03032,ko03400	-	-	-	HATPase_c,HTH_20,HTH_5
HKD2_k127_470181_2	394503.Ccel_2919	9.555e-34	133.0	COG0662@1|root,COG0662@2|Bacteria,1VEEQ@1239|Firmicutes,24JQ9@186801|Clostridia,36JMD@31979|Clostridiaceae	186801|Clostridia	G	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HKD2_k127_471947_0	931276.Cspa_c17420	7.865e-308	953.0	COG3250@1|root,COG3250@2|Bacteria,1TPDC@1239|Firmicutes,249UZ@186801|Clostridia,36VWR@31979|Clostridiaceae	186801|Clostridia	G	Belongs to the glycosyl hydrolase 2 family	-	-	3.2.1.23	ko:K01190	ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100	-	R01105,R01678,R03355,R04783,R06114	RC00049,RC00452	ko00000,ko00001,ko01000	-	-	-	DUF4982,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N
HKD2_k127_471947_1	697281.Mahau_2608	2.352e-141	459.0	COG3664@1|root,COG3664@2|Bacteria,1TQGI@1239|Firmicutes,2490Q@186801|Clostridia,42FZX@68295|Thermoanaerobacterales	186801|Clostridia	G	Glycosyl hydrolases family 39	-	-	3.2.1.37	ko:K01198	ko00520,ko01100,map00520,map01100	-	R01433	RC00467	ko00000,ko00001,ko01000	-	GH43	-	AraC_binding,Glyco_hydro_39,HTH_18
HKD2_k127_4791808_0	1031288.AXAA01000007_gene891	2.23e-125	410.0	COG0006@1|root,COG0006@2|Bacteria,1TQ44@1239|Firmicutes,247SG@186801|Clostridia,36E1G@31979|Clostridiaceae	186801|Clostridia	E	Belongs to the peptidase M24B family	-	-	3.4.11.9,3.4.13.9	ko:K01262,ko:K01271	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Peptidase_M24
HKD2_k127_4791808_1	903814.ELI_3489	6.302e-87	291.0	COG0231@1|root,COG0231@2|Bacteria,1TR8P@1239|Firmicutes,249DV@186801|Clostridia,25UWQ@186806|Eubacteriaceae	186801|Clostridia	J	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase	efp	-	-	ko:K02356	-	-	-	-	ko00000,ko03012	-	-	-	EFP,EFP_N,Elong-fact-P_C
HKD2_k127_4791808_2	293826.Amet_2491	3.902e-37	145.0	2E3FE@1|root,32YE8@2|Bacteria,1VFR0@1239|Firmicutes,24SIH@186801|Clostridia,36N3H@31979|Clostridiaceae	186801|Clostridia	S	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_479276_5	1291050.JAGE01000001_gene2158	3.698e-15	77.0	COG1595@1|root,COG1595@2|Bacteria,1TS3M@1239|Firmicutes,24GQ2@186801|Clostridia,3WINH@541000|Ruminococcaceae	186801|Clostridia	K	TIGRFAM RNA polymerase sigma factor, sigma-70 family	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD2_k127_479276_7	1195236.CTER_3633	1.456e-06	57.0	2EW20@1|root,33PF9@2|Bacteria,1UR8U@1239|Firmicutes,24W7Y@186801|Clostridia,3WP5X@541000|Ruminococcaceae	186801|Clostridia	S	Putative zinc-finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
HKD2_k127_479276_6	44251.PDUR_12305	6.22e-09	66.0	2CQ9E@1|root,32SKP@2|Bacteria,1V985@1239|Firmicutes,4HJAZ@91061|Bacilli,26XAC@186822|Paenibacillaceae	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_479276_1	1304284.L21TH_1898	1.574e-149	479.0	COG0533@1|root,COG0533@2|Bacteria,1TQDR@1239|Firmicutes,247MG@186801|Clostridia,36DHM@31979|Clostridiaceae	186801|Clostridia	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction	tsaD	-	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
HKD2_k127_479276_3	748449.Halha_0299	3.375e-97	333.0	COG0535@1|root,COG0535@2|Bacteria,1UMP8@1239|Firmicutes,24BXU@186801|Clostridia,3WABZ@53433|Halanaerobiales	186801|Clostridia	C	PFAM Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	DUF512,Fer4_14,PDZ,PDZ_2,Radical_SAM
HKD2_k127_479276_0	1304284.L21TH_1831	6.547e-194	623.0	COG0488@1|root,COG0488@2|Bacteria,1TPAX@1239|Firmicutes,247U6@186801|Clostridia,36E7X@31979|Clostridiaceae	186801|Clostridia	S	ABC transporter	-	-	-	ko:K06158	-	-	-	-	ko00000,ko03012	-	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
HKD2_k127_479276_4	445973.CLOBAR_00711	7.646e-89	297.0	COG2344@1|root,COG2344@2|Bacteria,1TSMR@1239|Firmicutes,247RQ@186801|Clostridia,25R18@186804|Peptostreptococcaceae	186801|Clostridia	K	Modulates transcription in response to changes in cellular NADH NAD( ) redox state	rex	-	-	ko:K01926	-	-	-	-	ko00000,ko03000	-	-	-	CoA_binding,Put_DNA-bind_N
HKD2_k127_479276_2	203119.Cthe_0509	1.511e-134	435.0	COG1883@1|root,COG1883@2|Bacteria,1TPEP@1239|Firmicutes,248ET@186801|Clostridia,3WHPY@541000|Ruminococcaceae	186801|Clostridia	C	Psort location CytoplasmicMembrane, score 10.00	-	-	4.1.1.3	ko:K01572	ko00620,ko01100,map00620,map01100	-	R00217	RC00040	ko00000,ko00001,ko01000,ko02000	3.B.1.1.1	-	-	OAD_beta
HKD2_k127_4836409_3	1230342.CTM_06911	2.781e-11	64.0	2C95S@1|root,33HPC@2|Bacteria,1VJZ1@1239|Firmicutes,24UBF@186801|Clostridia,36PHY@31979|Clostridiaceae	186801|Clostridia	S	Domain of unknown function (DUF4177)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4177
HKD2_k127_4836409_2	1294142.CINTURNW_1137	1.02e-49	181.0	COG1670@1|root,COG1670@2|Bacteria,1V365@1239|Firmicutes,24IZ5@186801|Clostridia,36JS9@31979|Clostridiaceae	186801|Clostridia	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_4
HKD2_k127_4836409_1	1499689.CCNN01000009_gene2814	5.321e-50	188.0	COG0842@1|root,COG0842@2|Bacteria,1TQ9K@1239|Firmicutes,24C8W@186801|Clostridia,36ID2@31979|Clostridiaceae	186801|Clostridia	V	ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
HKD2_k127_4836409_0	555088.DealDRAFT_1324	1.003e-87	299.0	COG1131@1|root,COG1131@2|Bacteria,1TQN1@1239|Firmicutes,25AZK@186801|Clostridia	186801|Clostridia	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD2_k127_4899576_0	398512.JQKC01000011_gene316	1.154e-98	329.0	COG0860@1|root,COG1649@1|root,COG0860@2|Bacteria,COG1649@2|Bacteria,1TRTG@1239|Firmicutes,24B2F@186801|Clostridia,3WGB4@541000|Ruminococcaceae	186801|Clostridia	M	lipoprotein YddW precursor K01189	-	-	-	-	-	-	-	-	-	-	-	-	Amidase_3,Big_2,GHL10
HKD2_k127_4899576_1	1121957.ATVL01000009_gene1047	3.171e-91	306.0	COG3384@1|root,COG3384@2|Bacteria,4NFGT@976|Bacteroidetes,47KW5@768503|Cytophagia	976|Bacteroidetes	S	PFAM Catalytic LigB subunit of aromatic ring-opening dioxygenase	-	-	-	ko:K15777	ko00965,map00965	-	R08836	RC00387	ko00000,ko00001,ko01000	-	-	-	LigB
HKD2_k127_5027955_3	1487921.DP68_01965	3.192e-41	154.0	COG0346@1|root,COG0346@2|Bacteria,1V48E@1239|Firmicutes	1239|Firmicutes	E	COG0346 LactoylglutaTHIone lyase and related lyases	yurT	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HKD2_k127_5027955_1	931626.Awo_c20530	1.203e-93	316.0	COG0778@1|root,COG0778@2|Bacteria,1V297@1239|Firmicutes,24FWY@186801|Clostridia,25YSV@186806|Eubacteriaceae	186801|Clostridia	C	Putative TM nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	TM1586_NiRdase
HKD2_k127_5027955_0	1286171.EAL2_c15700	2.01e-136	464.0	COG1948@1|root,COG4880@2|Bacteria,1TQK0@1239|Firmicutes,247VC@186801|Clostridia,25WEQ@186806|Eubacteriaceae	186801|Clostridia	L	Beta propeller domain	-	-	-	-	-	-	-	-	-	-	-	-	Beta_propel
HKD2_k127_5027955_2	268407.PWYN_24180	7.688e-75	255.0	2BJEK@1|root,32DR0@2|Bacteria,1VCPK@1239|Firmicutes	1239|Firmicutes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5044251_1	1230342.CTM_00610	2.252e-119	385.0	COG0003@1|root,COG0003@2|Bacteria,1TQZP@1239|Firmicutes,249JN@186801|Clostridia,36EXQ@31979|Clostridiaceae	186801|Clostridia	D	TIGRFAM arsenite-activated ATPase ArsA	arsA	-	3.6.3.16	ko:K01551	-	-	-	-	ko00000,ko01000,ko02000	3.A.19.1,3.A.21.1,3.A.4.1	-	-	ArsA_ATPase
HKD2_k127_5044251_2	698758.AXY_13880	4.45e-55	196.0	COG0394@1|root,COG5545@1|root,COG0394@2|Bacteria,COG5545@2|Bacteria,1TQNX@1239|Firmicutes,4HCHZ@91061|Bacilli	91061|Bacilli	T	Virulence-associated protein E	-	-	-	-	-	-	-	-	-	-	-	-	VirE
HKD2_k127_5044251_0	526218.Sterm_1303	1.418e-120	393.0	COG0798@1|root,COG0798@2|Bacteria,37BBN@32066|Fusobacteria	32066|Fusobacteria	P	PFAM Bile acid sodium symporter	-	-	-	ko:K03325	-	-	-	-	ko00000,ko02000	2.A.59	-	-	SBF
HKD2_k127_507982_1	941824.TCEL_00441	4.812e-62	221.0	COG1574@1|root,COG1574@2|Bacteria,1TQ6G@1239|Firmicutes,24A5F@186801|Clostridia,36DJ1@31979|Clostridiaceae	186801|Clostridia	S	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
HKD2_k127_507982_0	1321778.HMPREF1982_04274	2.781e-104	349.0	COG2603@1|root,COG2603@2|Bacteria,1TQ8T@1239|Firmicutes,24AM7@186801|Clostridia,26AVW@186813|unclassified Clostridiales	186801|Clostridia	S	Rhodanese Homology Domain	selU	-	-	ko:K06917	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Rhodanese
HKD2_k127_507982_2	1304284.L21TH_2496	8.08e-58	205.0	COG0715@1|root,COG0715@2|Bacteria,1TQN5@1239|Firmicutes,248IG@186801|Clostridia,36ENM@31979|Clostridiaceae	186801|Clostridia	P	ABC-type nitrate sulfonate bicarbonate transport	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
HKD2_k127_5113152_1	1286171.EAL2_c06720	3.582e-57	202.0	2E0JW@1|root,32W5C@2|Bacteria,1VBNI@1239|Firmicutes,24J6D@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5113152_0	290402.Cbei_1980	7.062e-153	490.0	COG1975@1|root,COG1975@2|Bacteria,1URM5@1239|Firmicutes,24AHV@186801|Clostridia,36G5G@31979|Clostridiaceae	186801|Clostridia	O	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family	-	-	-	ko:K07402	-	-	-	-	ko00000	-	-	-	XdhC_C,XdhC_CoxI
HKD2_k127_5113152_2	1321778.HMPREF1982_02969	1.678e-52	187.0	2D5AS@1|root,32TIN@2|Bacteria,1VA4E@1239|Firmicutes,24JJQ@186801|Clostridia,26BCD@186813|unclassified Clostridiales	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5113152_3	1321778.HMPREF1982_01872	1.469e-25	107.0	COG1309@1|root,COG1309@2|Bacteria,1VF0Y@1239|Firmicutes,24IZX@186801|Clostridia	186801|Clostridia	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
HKD2_k127_5114599_3	572547.Amico_0369	9.994e-61	215.0	COG3635@1|root,COG3635@2|Bacteria,3T9UQ@508458|Synergistetes	508458|Synergistetes	G	phosphoglycerate mutase	-	-	5.4.2.12	ko:K15635	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,PhosphMutase
HKD2_k127_5114599_10	1329516.JPST01000021_gene2321	2.226e-08	58.0	COG3339@1|root,COG3339@2|Bacteria,1VMH0@1239|Firmicutes,4IN4P@91061|Bacilli,27C9E@186824|Thermoactinomycetaceae	91061|Bacilli	S	Protein of unknown function (DUF1232)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1232
HKD2_k127_5114599_1	1128398.Curi_c09360	2.647e-130	436.0	COG0286@1|root,COG0286@2|Bacteria,1UMSN@1239|Firmicutes,24856@186801|Clostridia,26A00@186813|unclassified Clostridiales	186801|Clostridia	V	TaqI-like C-terminal specificity domain	-	-	2.1.1.72	ko:K07317	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	Eco57I,N6_Mtase,TaqI_C
HKD2_k127_5114599_6	218284.CCDN010000001_gene1086	1.932e-51	190.0	COG2339@1|root,COG2339@2|Bacteria,1UZGQ@1239|Firmicutes,4HCGD@91061|Bacilli,1ZBUQ@1386|Bacillus	91061|Bacilli	S	Involved in the degradation of specific anti-sigma factors	prsW	-	-	-	-	-	-	-	-	-	-	-	PrsW-protease
HKD2_k127_5114599_4	879308.HMPREF9130_1114	1.39e-53	194.0	COG2059@1|root,COG2059@2|Bacteria,1V42U@1239|Firmicutes,24HA0@186801|Clostridia,22H9I@1570339|Peptoniphilaceae	186801|Clostridia	P	Chromate transport protein	chrA	-	-	ko:K07240	-	-	-	-	ko00000,ko02000	2.A.51.1	-	-	Chromate_transp
HKD2_k127_5114599_5	865861.AZSU01000002_gene2909	8.463e-52	188.0	COG2059@1|root,COG2059@2|Bacteria,1V43H@1239|Firmicutes,24JTX@186801|Clostridia,36IGJ@31979|Clostridiaceae	186801|Clostridia	P	Chromate transport protein	chrA	-	-	ko:K07240	-	-	-	-	ko00000,ko02000	2.A.51.1	-	-	Chromate_transp
HKD2_k127_5114599_7	293826.Amet_4132	3.864e-42	162.0	COG0212@1|root,COG0212@2|Bacteria,1VA91@1239|Firmicutes,24N7H@186801|Clostridia,36JPF@31979|Clostridiaceae	186801|Clostridia	H	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family	yqgN	-	6.3.3.2	ko:K01934	ko00670,ko01100,map00670,map01100	-	R02301	RC00183	ko00000,ko00001,ko01000	-	-	-	5-FTHF_cyc-lig
HKD2_k127_5114599_9	394503.Ccel_3359	2.647e-27	117.0	2EY8W@1|root,33RHE@2|Bacteria,1VRH4@1239|Firmicutes,25DWM@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5114599_0	536227.CcarbDRAFT_1295	1.064e-237	747.0	COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247Q0@186801|Clostridia,36E4P@31979|Clostridiaceae	186801|Clostridia	V	ABC transporter	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
HKD2_k127_5114599_8	509191.AEDB02000055_gene3719	1.623e-28	121.0	2E8BQ@1|root,332QD@2|Bacteria,1VH5U@1239|Firmicutes,24R1P@186801|Clostridia,3WKW8@541000|Ruminococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5114599_2	386415.NT01CX_1338	4.736e-73	248.0	COG3773@1|root,COG3773@2|Bacteria,1V4KW@1239|Firmicutes,24GK5@186801|Clostridia,36I80@31979|Clostridiaceae	186801|Clostridia	M	Cell Wall	-	-	3.5.1.28	ko:K01449	-	-	R04112	RC00064,RC00141	ko00000,ko01000	-	-	-	Hydrolase_2
HKD2_k127_5133537_3	857293.CAAU_0186	4.052e-38	144.0	COG0228@1|root,COG0228@2|Bacteria,1VA0X@1239|Firmicutes,24MND@186801|Clostridia,36KP2@31979|Clostridiaceae	186801|Clostridia	J	Belongs to the bacterial ribosomal protein bS16 family	rpsP	-	-	ko:K02959	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S16
HKD2_k127_5133537_4	1031288.AXAA01000001_gene2274	2.328e-25	107.0	COG1837@1|root,COG1837@2|Bacteria,1VEG7@1239|Firmicutes,24QKN@186801|Clostridia,36KGX@31979|Clostridiaceae	186801|Clostridia	S	Belongs to the UPF0109 family	ylqC	-	-	ko:K06960	-	-	-	-	ko00000	-	-	-	KH_4
HKD2_k127_5133537_1	509191.AEDB02000003_gene1068	9.49e-57	203.0	COG0806@1|root,COG0806@2|Bacteria,1V6HD@1239|Firmicutes,24I1G@186801|Clostridia,3WIMH@541000|Ruminococcaceae	186801|Clostridia	J	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes	rimM	-	-	ko:K02860	-	-	-	-	ko00000,ko03009	-	-	-	PRC,RimM
HKD2_k127_5133537_0	1246626.BleG1_2277	8.876e-83	281.0	COG0336@1|root,COG0336@2|Bacteria,1TPBV@1239|Firmicutes,4HBFV@91061|Bacilli,1ZD4X@1386|Bacillus	91061|Bacilli	J	Belongs to the RNA methyltransferase TrmD family	trmD	GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050518,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.1.1.228	ko:K00554	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	tRNA_m1G_MT
HKD2_k127_5133537_2	748727.CLJU_c12930	6.442e-52	185.0	COG0335@1|root,COG0335@2|Bacteria,1V6FT@1239|Firmicutes,24J83@186801|Clostridia,36JJ4@31979|Clostridiaceae	186801|Clostridia	J	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site	rplS	-	-	ko:K02884	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L19
HKD2_k127_5133537_5	1399115.U719_10705	3.182e-09	58.0	COG1161@1|root,COG1161@2|Bacteria,1TQGK@1239|Firmicutes,4HA4D@91061|Bacilli,3WE9V@539002|Bacillales incertae sedis	91061|Bacilli	S	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity	rbgA	GO:0003674,GO:0003824,GO:0003924,GO:0008150,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0022613,GO:0042254,GO:0044085,GO:0071840	-	ko:K14540	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1
HKD2_k127_5142441_5	398512.JQKC01000033_gene5004	4.213e-55	201.0	COG0566@1|root,COG0566@2|Bacteria,1V3JP@1239|Firmicutes,248DV@186801|Clostridia,3WIQ9@541000|Ruminococcaceae	186801|Clostridia	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family	spoU	-	-	ko:K03437	-	-	-	-	ko00000,ko03016	-	-	-	SpoU_methylase,SpoU_sub_bind
HKD2_k127_5142441_3	350688.Clos_1974	1.406e-85	288.0	COG0569@1|root,COG0569@2|Bacteria,1TQ9H@1239|Firmicutes,249C2@186801|Clostridia,36DGN@31979|Clostridiaceae	186801|Clostridia	P	Potassium uptake protein	ktrC	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
HKD2_k127_5142441_2	293826.Amet_1636	1.564e-148	483.0	COG0168@1|root,COG0168@2|Bacteria,1TQ4S@1239|Firmicutes,247Q3@186801|Clostridia,36DPR@31979|Clostridiaceae	186801|Clostridia	P	potassium uptake protein, TrkH family	ktrB	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
HKD2_k127_5142441_6	1216932.CM240_2095	4.692e-48	174.0	COG0292@1|root,COG0292@2|Bacteria,1V6DB@1239|Firmicutes,24JBJ@186801|Clostridia,36ITT@31979|Clostridiaceae	186801|Clostridia	J	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit	rplT	-	-	ko:K02887	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L20
HKD2_k127_5142441_7	1235797.C816_03316	1.052e-17	84.0	COG0291@1|root,COG0291@2|Bacteria,1VF5W@1239|Firmicutes,24QJD@186801|Clostridia,2N7QV@216572|Oscillospiraceae	186801|Clostridia	J	Ribosomal protein L35	rpmI	-	-	ko:K02916	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L35p
HKD2_k127_5142441_4	555079.Toce_1404	3.279e-65	229.0	COG0290@1|root,COG0290@2|Bacteria,1V1RC@1239|Firmicutes,24FUS@186801|Clostridia,42G8T@68295|Thermoanaerobacterales	186801|Clostridia	J	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins	infC	-	-	ko:K02520	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	IF3_C,IF3_N
HKD2_k127_5142441_1	246194.CHY_2216	1.116e-152	496.0	COG0624@1|root,COG0624@2|Bacteria,1TPEG@1239|Firmicutes,247SK@186801|Clostridia,42F73@68295|Thermoanaerobacterales	186801|Clostridia	E	PFAM Peptidase M20	ytjP	-	3.5.1.18	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R02734	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
HKD2_k127_5142441_0	720554.Clocl_3036	7.2e-322	995.0	COG0441@1|root,COG0441@2|Bacteria,1TP78@1239|Firmicutes,248CH@186801|Clostridia,3WGVM@541000|Ruminococcaceae	186801|Clostridia	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	-	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD
HKD2_k127_5156959_2	1449126.JQKL01000001_gene1463	1.258e-27	125.0	COG3290@1|root,COG3437@1|root,COG3290@2|Bacteria,COG3437@2|Bacteria,1TQ0S@1239|Firmicutes,24800@186801|Clostridia,26AR3@186813|unclassified Clostridiales	186801|Clostridia	T	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,HD_5,PAS,PAS_4,PAS_9
HKD2_k127_5156959_1	1321778.HMPREF1982_01216	1.084e-34	139.0	2EA57@1|root,334A4@2|Bacteria,1VHEA@1239|Firmicutes,24RNE@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5156959_0	293826.Amet_0591	3.913e-145	463.0	COG1070@1|root,COG1070@2|Bacteria,1TQ1I@1239|Firmicutes,247NR@186801|Clostridia,36F3K@31979|Clostridiaceae	186801|Clostridia	G	Carbohydrate kinase, FGGY	xylB	-	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
HKD2_k127_5158482_4	1304284.L21TH_0804	5.099e-55	196.0	COG0634@1|root,COG0634@2|Bacteria,1V1C9@1239|Firmicutes,24FR4@186801|Clostridia,36HYM@31979|Clostridiaceae	186801|Clostridia	F	Belongs to the purine pyrimidine phosphoribosyltransferase family	hpt	-	2.4.2.8	ko:K00760	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	-	R00190,R01132,R01229,R02142,R08237,R08238,R08245	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	Pribosyltran
HKD2_k127_5158482_1	350688.Clos_0431	1.446e-123	411.0	COG0037@1|root,COG0037@2|Bacteria,1TPXP@1239|Firmicutes,248TY@186801|Clostridia,36EWX@31979|Clostridiaceae	186801|Clostridia	D	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine	tilS	-	6.3.4.19	ko:K04075	-	-	R09597	RC02633,RC02634	ko00000,ko01000,ko03016	-	-	-	ATP_bind_3,TilS,TilS_C
HKD2_k127_5158482_6	1128398.Curi_c23700	3.291e-44	171.0	COG0515@1|root,COG0515@2|Bacteria,1TSNS@1239|Firmicutes,24IDZ@186801|Clostridia	186801|Clostridia	KLT	SMART serine	-	-	2.7.11.1	ko:K08884	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HKD2_k127_5158482_3	1304284.L21TH_0807	6.619e-56	206.0	COG1240@1|root,COG1240@2|Bacteria,1UHZH@1239|Firmicutes,24JM8@186801|Clostridia,36KA1@31979|Clostridiaceae	186801|Clostridia	H	von Willebrand factor type A domain	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VWA
HKD2_k127_5158482_0	588581.Cpap_0309	9.372e-162	537.0	COG2208@1|root,COG2208@2|Bacteria,1TQ92@1239|Firmicutes,247XG@186801|Clostridia,3WH68@541000|Ruminococcaceae	186801|Clostridia	KT	stage II sporulation protein E	spoIIE	-	3.1.3.16	ko:K06382	-	-	-	-	ko00000,ko01000	-	-	-	SpoIIE
HKD2_k127_5158482_2	1286171.EAL2_c02540	1.087e-72	256.0	COG0248@1|root,COG0248@2|Bacteria,1V978@1239|Firmicutes,25CYW@186801|Clostridia	186801|Clostridia	FP	Ppx/GppA phosphatase family	-	-	3.6.1.11,3.6.1.40	ko:K01524	ko00230,map00230	-	R03409	RC00002	ko00000,ko00001,ko01000	-	-	-	Ppx-GppA
HKD2_k127_5158482_5	935948.KE386495_gene1362	3.951e-46	170.0	COG1098@1|root,COG1098@2|Bacteria,1V6FE@1239|Firmicutes,24MPT@186801|Clostridia,42GIA@68295|Thermoanaerobacterales	186801|Clostridia	J	PFAM RNA binding S1 domain protein	yugI	-	-	ko:K07570,ko:K07571	-	-	-	-	ko00000	-	-	-	S1
HKD2_k127_5173515_2	237368.SCABRO_00564	1.192e-33	133.0	COG3945@1|root,COG3945@2|Bacteria,2J2KE@203682|Planctomycetes	203682|Planctomycetes	S	Hemerythrin HHE cation binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
HKD2_k127_5173515_4	649747.HMPREF0083_04212	2.925e-08	65.0	COG0531@1|root,COG0531@2|Bacteria,1UZ73@1239|Firmicutes,4HE8G@91061|Bacilli,26QE3@186822|Paenibacillaceae	91061|Bacilli	E	Spore gernimation protein	-	-	-	ko:K06296	-	-	-	-	ko00000,ko02000	2.A.3.9.3	-	-	Spore_permease
HKD2_k127_5173515_1	398512.JQKC01000002_gene1676	5.526e-65	237.0	2DBJR@1|root,2Z9N7@2|Bacteria,1TRSN@1239|Firmicutes,249AT@186801|Clostridia,3WKX8@541000|Ruminococcaceae	186801|Clostridia	S	Spore germination B3/ GerAC like, C-terminal	-	-	-	ko:K06297	-	-	-	-	ko00000	-	-	-	Spore_GerAC
HKD2_k127_5173515_0	398512.JQKC01000002_gene1677	1.196e-157	511.0	COG0697@1|root,COG0697@2|Bacteria,1TP7K@1239|Firmicutes,248Q8@186801|Clostridia,3WHDF@541000|Ruminococcaceae	186801|Clostridia	EG	spore germination protein	gerKA1	-	-	ko:K06295	-	-	-	-	ko00000	-	-	-	GerA
HKD2_k127_5173515_3	1511.CLOST_0116	2.189e-28	115.0	COG4728@1|root,COG4728@2|Bacteria,1TUDF@1239|Firmicutes,25832@186801|Clostridia,25U7I@186804|Peptostreptococcaceae	186801|Clostridia	S	Protein of unknown function (DUF1653)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1653
HKD2_k127_5173515_5	1443122.Z958_08190	1.149e-07	57.0	COG2199@1|root,COG3706@2|Bacteria,1V9S3@1239|Firmicutes,24B6H@186801|Clostridia,36HPD@31979|Clostridiaceae	186801|Clostridia	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
HKD2_k127_5183750_2	1408422.JHYF01000002_gene2602	5.458e-78	264.0	COG1131@1|root,COG1131@2|Bacteria,1TS5Y@1239|Firmicutes,24AH1@186801|Clostridia,36FUM@31979|Clostridiaceae	186801|Clostridia	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD2_k127_5183750_4	1408422.JHYF01000002_gene2603	4.392e-39	154.0	2EDJ2@1|root,337EY@2|Bacteria,1VERQ@1239|Firmicutes,24M7K@186801|Clostridia,36K3K@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5183750_0	1121335.Clst_1455	3.05e-208	654.0	COG1388@1|root,COG2866@1|root,COG3409@1|root,COG1388@2|Bacteria,COG2866@2|Bacteria,COG3409@2|Bacteria,1TP3K@1239|Firmicutes,249MT@186801|Clostridia,3WHJW@541000|Ruminococcaceae	186801|Clostridia	EM	Carboxypeptidase	-	-	3.4.19.11	ko:K01308	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	LysM,PG_binding_1,Peptidase_M14
HKD2_k127_5183750_3	1410653.JHVC01000001_gene1601	2.651e-65	231.0	COG0861@1|root,COG0861@2|Bacteria,1UYA9@1239|Firmicutes,247W4@186801|Clostridia,36F1X@31979|Clostridiaceae	186801|Clostridia	P	PFAM Integral membrane protein TerC	-	-	-	-	-	-	-	-	-	-	-	-	TerC
HKD2_k127_5183750_1	642492.Clole_2000	5.315e-83	285.0	COG0583@1|root,COG0583@2|Bacteria,1TP6T@1239|Firmicutes,24970@186801|Clostridia	186801|Clostridia	K	transcriptional regulator	-	-	-	ko:K21900	-	-	-	-	ko00000,ko03000	-	-	-	HTH_1,LysR_substrate
HKD2_k127_5183750_5	1121342.AUCO01000005_gene159	1.606e-24	104.0	COG0695@1|root,COG0695@2|Bacteria,1VK60@1239|Firmicutes,25DYV@186801|Clostridia	186801|Clostridia	O	Glutathione S-transferase, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Glutaredoxin
HKD2_k127_5190280_3	272558.10176554	1.925e-111	367.0	COG0454@1|root,COG0456@2|Bacteria,1UXXB@1239|Firmicutes,4HEEJ@91061|Bacilli,1ZS91@1386|Bacillus	91061|Bacilli	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_9
HKD2_k127_5190280_5	290402.Cbei_2065	6.97e-60	213.0	COG1309@1|root,COG1309@2|Bacteria,1V7FV@1239|Firmicutes,25B6I@186801|Clostridia,36WC5@31979|Clostridiaceae	186801|Clostridia	K	PFAM regulatory protein TetR	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
HKD2_k127_5190280_0	871963.Desdi_0891	0.0	1250.0	COG0574@1|root,COG3848@1|root,COG0574@2|Bacteria,COG3848@2|Bacteria,1UIEA@1239|Firmicutes,25EJM@186801|Clostridia	186801|Clostridia	GT	pyruvate phosphate dikinase, PEP	ppdK	-	2.7.9.1,2.7.9.2	ko:K01006,ko:K01007	ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173,M00374	R00199,R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
HKD2_k127_5190280_1	138119.DSY4220	1.211e-174	557.0	COG0477@1|root,COG0477@2|Bacteria,1TPHW@1239|Firmicutes,2492B@186801|Clostridia	186801|Clostridia	P	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD2_k127_5190280_2	350688.Clos_2321	1.443e-154	492.0	COG2207@1|root,COG3708@1|root,COG2207@2|Bacteria,COG3708@2|Bacteria,1TPI9@1239|Firmicutes,25BEE@186801|Clostridia	186801|Clostridia	K	Bacterial transcription activator, effector binding domain	-	-	-	ko:K13653	-	-	-	-	ko00000,ko03000	-	-	-	Cass2,HTH_18
HKD2_k127_5190280_4	457396.CSBG_02415	4.734e-82	282.0	COG2017@1|root,COG2017@2|Bacteria,1TQGJ@1239|Firmicutes,249DZ@186801|Clostridia,36F59@31979|Clostridiaceae	186801|Clostridia	G	Converts alpha-aldose to the beta-anomer	-	-	5.1.3.3	ko:K01785	ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130	M00632	R01602,R10619	RC00563	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldose_epim
HKD2_k127_5194838_0	1408422.JHYF01000004_gene1665	7.899e-224	701.0	COG2203@1|root,COG3437@1|root,COG2203@2|Bacteria,COG3437@2|Bacteria,1TQ0S@1239|Firmicutes,24800@186801|Clostridia,36E1T@31979|Clostridiaceae	186801|Clostridia	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	DUF3369,GGDEF,HD,PAS,Response_reg
HKD2_k127_5194838_1	1120998.AUFC01000009_gene2130	6.041e-125	404.0	COG0789@1|root,COG4978@1|root,COG0789@2|Bacteria,COG4978@2|Bacteria,1V37U@1239|Firmicutes,25AZY@186801|Clostridia	186801|Clostridia	K	transcriptional regulator, MerR family	-	-	-	-	-	-	-	-	-	-	-	-	GyrI-like,MerR_1
HKD2_k127_5194838_2	1031288.AXAA01000022_gene1553	1.396e-14	79.0	COG1387@1|root,COG5263@1|root,COG5492@1|root,COG1387@2|Bacteria,COG5263@2|Bacteria,COG5492@2|Bacteria,1UIHY@1239|Firmicutes,25FMJ@186801|Clostridia,36V3J@31979|Clostridiaceae	186801|Clostridia	EN	Bacterial Ig-like domain 2	-	-	-	-	-	-	-	-	-	-	-	-	Big_2
HKD2_k127_5200919_0	332101.JIBU02000037_gene1559	2.434e-203	638.0	COG0137@1|root,COG0137@2|Bacteria,1TP3X@1239|Firmicutes,247MF@186801|Clostridia,36DGQ@31979|Clostridiaceae	186801|Clostridia	E	Belongs to the argininosuccinate synthase family. Type 1 subfamily	argG	-	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Arginosuc_synth
HKD2_k127_5200919_1	1443122.Z958_09165	1.895e-36	139.0	COG0165@1|root,COG0165@2|Bacteria,1TNZ6@1239|Firmicutes,2489H@186801|Clostridia,36E9J@31979|Clostridiaceae	186801|Clostridia	E	argininosuccinate lyase	argH	-	4.3.2.1	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01086	RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ASL_C2,Lyase_1
HKD2_k127_5204804_2	1123511.KB905842_gene1676	3.988e-10	61.0	COG2070@1|root,COG2070@2|Bacteria,1TPX1@1239|Firmicutes,4H2U5@909932|Negativicutes	909932|Negativicutes	S	Oxidoreductase 2-nitropropane dioxygenase family protein	-	-	-	-	-	-	-	-	-	-	-	-	NMO
HKD2_k127_5204804_1	1499683.CCFF01000017_gene2640	1.343e-213	671.0	COG2252@1|root,COG2252@2|Bacteria,1TQC6@1239|Firmicutes,2483Q@186801|Clostridia,36DY4@31979|Clostridiaceae	186801|Clostridia	S	Permease	-	-	-	ko:K06901	-	-	-	-	ko00000,ko02000	2.A.1.40	-	-	Xan_ur_permease
HKD2_k127_5204804_0	1304880.JAGB01000001_gene618	7.529e-260	811.0	COG3383@1|root,COG4624@1|root,COG3383@2|Bacteria,COG4624@2|Bacteria,1TP6C@1239|Firmicutes,24897@186801|Clostridia	186801|Clostridia	C	hydrogenase large subunit	-	-	1.12.1.3,1.6.5.3	ko:K00336,ko:K18332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fe_hyd_SSU,Fe_hyd_lg_C,Fer2_4,Fer4,Fer4_6,Fer4_7,NADH-G_4Fe-4S_3
HKD2_k127_5207742_5	1031288.AXAA01000003_gene1729	1.883e-190	601.0	COG4213@1|root,COG4213@2|Bacteria,1TR3Q@1239|Firmicutes,2482X@186801|Clostridia,36E6T@31979|Clostridiaceae	186801|Clostridia	G	ABC-type xylose transport system, periplasmic component	-	-	-	ko:K10546	ko02010,map02010	M00216	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.5	-	-	Peripla_BP_4
HKD2_k127_5207742_7	697303.Thewi_0287	2.189e-143	462.0	COG4213@1|root,COG4213@2|Bacteria,1TR3Q@1239|Firmicutes,2482X@186801|Clostridia,42EV1@68295|Thermoanaerobacterales	186801|Clostridia	G	PFAM Periplasmic binding protein LacI transcriptional regulator	xylF	-	3.6.3.17	ko:K10543,ko:K10820	ko02010,map02010	M00215	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.4	-	-	Peripla_BP_4
HKD2_k127_5207742_4	1031288.AXAA01000003_gene1727	2.495e-197	628.0	COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1TSKR@1239|Firmicutes,24AFC@186801|Clostridia,36FBQ@31979|Clostridiaceae	186801|Clostridia	T	response regulator	-	-	-	ko:K07720	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_18,HTH_AraC,Response_reg
HKD2_k127_5207742_3	857293.CAAU_0343	2.343e-212	670.0	COG2972@1|root,COG2972@2|Bacteria,1TSF9@1239|Firmicutes,2499Y@186801|Clostridia,36VHD@31979|Clostridiaceae	186801|Clostridia	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,His_kinase
HKD2_k127_5207742_9	857293.CAAU_0344	1.461e-132	430.0	COG1879@1|root,COG1879@2|Bacteria,1TQZS@1239|Firmicutes,25AZW@186801|Clostridia,36ECG@31979|Clostridiaceae	186801|Clostridia	G	Periplasmic binding protein LacI transcriptional regulator	-	-	-	ko:K10439	ko02010,ko02030,map02010,map02030	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	Peripla_BP_4
HKD2_k127_5207742_1	748727.CLJU_c19770	0.0	1035.0	COG0326@1|root,COG0326@2|Bacteria,1TQEU@1239|Firmicutes,247ND@186801|Clostridia,36DJ5@31979|Clostridiaceae	186801|Clostridia	O	Molecular chaperone. Has ATPase activity	htpG	-	-	ko:K04079	ko04141,ko04151,ko04217,ko04612,ko04621,ko04626,ko04657,ko04659,ko04914,ko04915,ko05200,ko05215,ko05418,map04141,map04151,map04217,map04612,map04621,map04626,map04657,map04659,map04914,map04915,map05200,map05215,map05418	-	-	-	ko00000,ko00001,ko01009,ko03029,ko03051,ko03110,ko04131,ko04147	-	-	-	HATPase_c,HATPase_c_3,HSP90
HKD2_k127_5207742_6	37659.JNLN01000001_gene2098	5.287e-153	492.0	COG0639@1|root,COG0639@2|Bacteria,1UYWX@1239|Firmicutes,24DAC@186801|Clostridia,36GK8@31979|Clostridiaceae	186801|Clostridia	T	Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos,Metallophos_2
HKD2_k127_5207742_8	138119.DSY1225	4.98e-141	454.0	COG1307@1|root,COG1307@2|Bacteria,1UCTG@1239|Firmicutes,249QI@186801|Clostridia	186801|Clostridia	S	Uncharacterised protein, DegV family COG1307	-	-	-	-	-	-	-	-	-	-	-	-	DegV
HKD2_k127_5207742_0	1286171.EAL2_808p02940	0.0	1111.0	COG0550@1|root,COG0550@2|Bacteria,1TPJD@1239|Firmicutes,24810@186801|Clostridia,25VB6@186806|Eubacteriaceae	186801|Clostridia	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	traI	-	5.99.1.2	ko:K03169	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	Topoisom_bac,Toprim,Toprim_Crpt
HKD2_k127_5207742_11	573061.Clocel_0821	8.514e-89	295.0	COG0847@1|root,COG0847@2|Bacteria,1VTCG@1239|Firmicutes,24DSA@186801|Clostridia,36FFW@31979|Clostridiaceae	186801|Clostridia	L	breast cancer carboxy-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	BRCT,RNase_T
HKD2_k127_5207742_10	350688.Clos_1209	7.621e-105	360.0	COG0747@1|root,COG0747@2|Bacteria,1TQ0N@1239|Firmicutes,25CDM@186801|Clostridia,36WU4@31979|Clostridiaceae	186801|Clostridia	E	PFAM extracellular solute-binding protein, family 5	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
HKD2_k127_5207742_13	431943.CKL_0671	3.071e-51	187.0	COG0741@1|root,COG0741@2|Bacteria,1V6K4@1239|Firmicutes,24JB5@186801|Clostridia,36J2Z@31979|Clostridiaceae	186801|Clostridia	M	transglycosylase	slt	-	-	ko:K08309	-	-	-	-	ko00000,ko01000,ko01011	-	GH23	-	SLT
HKD2_k127_5207742_12	580331.Thit_0812	5.087e-63	222.0	COG0237@1|root,COG0237@2|Bacteria,1V6FS@1239|Firmicutes,24GFQ@186801|Clostridia,42G1K@68295|Thermoanaerobacterales	186801|Clostridia	F	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A	coaE	-	2.7.1.24	ko:K00859	ko00770,ko01100,map00770,map01100	M00120	R00130	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	CoaE
HKD2_k127_5207742_2	1304284.L21TH_2157	2.868e-282	892.0	COG0749@1|root,COG0749@2|Bacteria,1TPKJ@1239|Firmicutes,248NG@186801|Clostridia,36EWE@31979|Clostridiaceae	186801|Clostridia	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
HKD2_k127_5207742_14	1408422.JHYF01000002_gene2311	1.044e-47	186.0	COG5662@1|root,COG5662@2|Bacteria,1UHWV@1239|Firmicutes,24JF8@186801|Clostridia,36K4C@31979|Clostridiaceae	186801|Clostridia	K	Domain of unknown function (DUF4349)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4349,zf-HC2
HKD2_k127_5208748_4	340099.Teth39_1494	3.507e-94	314.0	COG0044@1|root,COG0044@2|Bacteria,1TPI6@1239|Firmicutes,2495I@186801|Clostridia,42EUG@68295|Thermoanaerobacterales	186801|Clostridia	E	Catalyzes the hydrolytic cleavage of a subset of L- isoaspartyl (L-beta-aspartyl) dipeptides. Used to degrade proteins damaged by L-isoaspartyl residues formation	iadA	-	-	ko:K01305	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Amidohydro_1,Amidohydro_3
HKD2_k127_5208748_1	632335.Calkr_0371	1.83e-193	611.0	COG0156@1|root,COG0156@2|Bacteria,1TPUX@1239|Firmicutes,2491D@186801|Clostridia,42FUG@68295|Thermoanaerobacterales	186801|Clostridia	H	PFAM Aminotransferase class I and II	kbl	GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008710,GO:0008890,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016407,GO:0016408,GO:0016453,GO:0016740,GO:0016746,GO:0016747,GO:0017144,GO:0018130,GO:0019752,GO:0019842,GO:0030170,GO:0032787,GO:0034641,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0070279,GO:0071704,GO:0072330,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.3.1.29,2.3.1.47,6.2.1.14	ko:K00639,ko:K00652,ko:K01906	ko00260,ko00780,ko01100,map00260,map00780,map01100	M00123,M00573,M00577	R00371,R03209,R03210,R10124	RC00004,RC00014,RC00039,RC00394,RC02725	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
HKD2_k127_5208748_3	1321778.HMPREF1982_00105	1.896e-94	317.0	COG0300@1|root,COG0300@2|Bacteria,1UHN7@1239|Firmicutes,25FVQ@186801|Clostridia	186801|Clostridia	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HKD2_k127_5208748_10	768704.Desmer_3476	1.409e-23	117.0	COG3391@1|root,COG3391@2|Bacteria,1UDPD@1239|Firmicutes,25IGB@186801|Clostridia,266QQ@186807|Peptococcaceae	186801|Clostridia	S	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5208748_7	398512.JQKC01000007_gene1058	7.169e-83	292.0	COG0642@1|root,COG2205@2|Bacteria,1UC3A@1239|Firmicutes,25B83@186801|Clostridia	186801|Clostridia	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
HKD2_k127_5208748_8	398512.JQKC01000007_gene1059	3.297e-75	260.0	COG0745@1|root,COG0745@2|Bacteria,1TPZ0@1239|Firmicutes,249IC@186801|Clostridia,3WGB8@541000|Ruminococcaceae	186801|Clostridia	T	response regulator receiver	resD	-	-	ko:K07775	ko02020,map02020	M00458	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
HKD2_k127_5208748_2	1340434.AXVA01000023_gene3374	2.829e-154	496.0	COG1473@1|root,COG1473@2|Bacteria,1TQ7B@1239|Firmicutes,4HAIK@91061|Bacilli,1ZDIH@1386|Bacillus	91061|Bacilli	S	amidohydrolase	hipO3	-	-	ko:K21613	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20
HKD2_k127_5208748_0	697281.Mahau_0741	3.674e-237	747.0	COG1164@1|root,COG1164@2|Bacteria,1TP4P@1239|Firmicutes,248TP@186801|Clostridia,42EXS@68295|Thermoanaerobacterales	186801|Clostridia	E	M3B, thimet oligopeptidase F	pepF	-	-	ko:K08602	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3,Peptidase_M3_N
HKD2_k127_5208748_9	498761.HM1_1469	3.971e-43	168.0	2EJJQ@1|root,33DAK@2|Bacteria,1VNE2@1239|Firmicutes,24H41@186801|Clostridia	186801|Clostridia	S	Putative amidase domain	-	-	-	-	-	-	-	-	-	-	-	-	Amidase_6
HKD2_k127_5208748_12	1304284.L21TH_2313	5.262e-09	59.0	2DIM4@1|root,303KY@2|Bacteria,1TUTJ@1239|Firmicutes,25K9A@186801|Clostridia,36PUC@31979|Clostridiaceae	186801|Clostridia	S	Spore coat associated protein JA (CotJA)	-	-	-	-	-	-	-	-	-	-	-	-	CotJA
HKD2_k127_5208748_11	1304284.L21TH_2314	2.867e-22	99.0	2E34J@1|root,32Y4N@2|Bacteria,1VESM@1239|Firmicutes,24QZX@186801|Clostridia,36MN8@31979|Clostridiaceae	186801|Clostridia	S	CotJB protein	cotJB	-	-	ko:K06333	-	-	-	-	ko00000	-	-	-	CotJB
HKD2_k127_5208748_6	555079.Toce_0726	5.163e-85	284.0	COG3546@1|root,COG3546@2|Bacteria,1TQVQ@1239|Firmicutes,247YJ@186801|Clostridia,42EVJ@68295|Thermoanaerobacterales	186801|Clostridia	P	PFAM Manganese containing catalase	cotJC	-	-	ko:K06334	-	-	-	-	ko00000	-	-	-	Mn_catalase
HKD2_k127_5208748_5	138119.DSY1670	6.236e-88	298.0	COG1307@1|root,COG1307@2|Bacteria,1TYCV@1239|Firmicutes,248JV@186801|Clostridia,260Z1@186807|Peptococcaceae	186801|Clostridia	S	PFAM Uncharacterised protein, DegV family COG1307	-	-	-	-	-	-	-	-	-	-	-	-	DegV
HKD2_k127_5212004_1	1408422.JHYF01000008_gene3747	5.949e-148	475.0	COG4108@1|root,COG4108@2|Bacteria,1TPYT@1239|Firmicutes,247X3@186801|Clostridia,36DUQ@31979|Clostridiaceae	186801|Clostridia	J	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP	prfC	-	-	ko:K02837	-	-	-	-	ko00000,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,RF3_C
HKD2_k127_5212004_0	411469.EUBHAL_00307	9.746e-204	647.0	COG1227@1|root,COG1227@2|Bacteria,1TPH6@1239|Firmicutes,248RQ@186801|Clostridia,25US0@186806|Eubacteriaceae	186801|Clostridia	C	Psort location Cytoplasmic, score	ppaC	-	3.6.1.1	ko:K15986	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	CBS,DHH,DHHA2,DRTGG
HKD2_k127_5212004_2	913865.DOT_5962	3.555e-83	283.0	COG0730@1|root,COG0730@2|Bacteria,1TQBK@1239|Firmicutes,24A0G@186801|Clostridia,266PW@186807|Peptococcaceae	186801|Clostridia	S	PFAM Sulfite exporter TauE SafE	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
HKD2_k127_5212004_4	1487921.DP68_05465	8.634e-36	140.0	COG0607@1|root,COG0607@2|Bacteria,1U0PW@1239|Firmicutes,24RKU@186801|Clostridia,36KH8@31979|Clostridiaceae	186801|Clostridia	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese,TusA
HKD2_k127_5212004_3	913865.DOT_6283	2.856e-45	166.0	COG0446@1|root,COG0607@1|root,COG2210@1|root,COG0446@2|Bacteria,COG0607@2|Bacteria,COG2210@2|Bacteria,1TPWW@1239|Firmicutes,2484C@186801|Clostridia,2606T@186807|Peptococcaceae	186801|Clostridia	P	pyridine nucleotide-disulphide oxidoreductase dimerisation	cdr	-	-	-	-	-	-	-	-	-	-	-	DrsE_2,Pyr_redox_2,Pyr_redox_dim,Rhodanese,TusA
HKD2_k127_5219538_0	1499689.CCNN01000006_gene357	0.0	1172.0	COG2987@1|root,COG2987@2|Bacteria,1TPZ9@1239|Firmicutes,247YS@186801|Clostridia,36DK8@31979|Clostridiaceae	186801|Clostridia	E	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate	hutU	-	4.2.1.49	ko:K01712	ko00340,ko01100,map00340,map01100	M00045	R02914	RC00804	ko00000,ko00001,ko00002,ko01000	-	-	-	Urocanase,Urocanase_C,Urocanase_N
HKD2_k127_5219538_2	1235813.JCM10003_1825	3.763e-139	447.0	COG3643@1|root,COG3643@2|Bacteria,4NFE3@976|Bacteroidetes,2FMWT@200643|Bacteroidia,4AMG0@815|Bacteroidaceae	976|Bacteroidetes	E	Glutamate formiminotransferase	ftcD	-	2.1.2.5,4.3.1.4	ko:K00603,ko:K13990	ko00340,ko00670,ko01100,map00340,map00670,map01100	-	R02287,R02302,R03189	RC00165,RC00221,RC00223,RC00688,RC00870	ko00000,ko00001,ko01000,ko03036,ko04147	-	-	-	FTCD,FTCD_C,FTCD_N
HKD2_k127_5219538_1	796940.HMPREF9628_00867	2.72e-264	823.0	COG2759@1|root,COG2759@2|Bacteria,1TP6N@1239|Firmicutes,247P5@186801|Clostridia,25QRD@186804|Peptostreptococcaceae	186801|Clostridia	H	Formyltetrahydrofolate synthetase	fhs	-	6.3.4.3	ko:K01938	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R00943	RC00026,RC00111	ko00000,ko00001,ko00002,ko01000	-	-	-	FTHFS
HKD2_k127_5219538_3	293826.Amet_4611	3.558e-25	108.0	COG0860@1|root,COG2385@1|root,COG0860@2|Bacteria,COG2385@2|Bacteria,1UYPW@1239|Firmicutes,24CB9@186801|Clostridia,36EPH@31979|Clostridiaceae	186801|Clostridia	DM	Ami_3	-	-	-	-	-	-	-	-	-	-	-	-	Amidase_3,SpoIID
HKD2_k127_5240531_3	509191.AEDB02000019_gene4532	8.527e-36	138.0	COG1457@1|root,COG1457@2|Bacteria,1UKST@1239|Firmicutes,25G2N@186801|Clostridia,3WSSB@541000|Ruminococcaceae	2|Bacteria	F	Spore germination protein	-	-	-	-	-	-	-	-	-	-	-	-	Spore_permease
HKD2_k127_5240531_4	509191.AEDB02000073_gene1838	3.123e-22	97.0	2E5EX@1|root,3306S@2|Bacteria,1VH1E@1239|Firmicutes,24TFC@186801|Clostridia,3WQS2@541000|Ruminococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5240531_1	536227.CcarbDRAFT_2337	1.057e-146	473.0	28M4H@1|root,2ZAIE@2|Bacteria,1TPXD@1239|Firmicutes,25EJK@186801|Clostridia,36UXI@31979|Clostridiaceae	186801|Clostridia	S	PFAM spore germination B3 GerAC	gerAC	-	-	ko:K06297	-	-	-	-	ko00000	-	-	-	Spore_GerAC
HKD2_k127_5240531_0	509191.AEDB02000019_gene4529	9.279e-260	809.0	COG0697@1|root,COG0697@2|Bacteria,1TP7K@1239|Firmicutes,248Q8@186801|Clostridia,3WHDF@541000|Ruminococcaceae	186801|Clostridia	EG	spore germination protein	-	-	-	ko:K06295	-	-	-	-	ko00000	-	-	-	GerA
HKD2_k127_5240531_2	1094508.Tsac_2471	5.264e-50	188.0	COG1482@1|root,COG1482@2|Bacteria,1V0PH@1239|Firmicutes,2487K@186801|Clostridia,42F26@68295|Thermoanaerobacterales	186801|Clostridia	G	PFAM mannose-6-phosphate isomerase type I	manA	-	5.3.1.8	ko:K01809	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114	R01819	RC00376	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS19425	PMI_typeI
HKD2_k127_5240531_5	588581.Cpap_2323	7.344e-05	45.0	COG3973@1|root,COG3973@2|Bacteria,1TP39@1239|Firmicutes,249IG@186801|Clostridia,3WHDZ@541000|Ruminococcaceae	186801|Clostridia	L	Superfamily I DNA and RNA	-	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AAA_19,UvrD-helicase,UvrD_C,UvrD_C_2
HKD2_k127_5242457_1	1408422.JHYF01000018_gene1754	2.92e-61	217.0	COG0189@1|root,COG0769@1|root,COG0189@2|Bacteria,COG0769@2|Bacteria,1V3WY@1239|Firmicutes,249AA@186801|Clostridia,36ED3@31979|Clostridiaceae	186801|Clostridia	HJM	cyanophycin synthetase	cphA	-	6.3.2.29,6.3.2.30	ko:K03802	-	-	-	-	ko00000,ko01000	-	-	-	Mur_ligase_C,Mur_ligase_M,RimK
HKD2_k127_5242457_0	717606.PaecuDRAFT_1587	4.055e-134	439.0	COG3214@1|root,COG3214@2|Bacteria,1TSHT@1239|Firmicutes,4HCCE@91061|Bacilli,26TSW@186822|Paenibacillaceae	91061|Bacilli	S	Winged helix DNA-binding domain	-	-	-	ko:K09927	-	-	-	-	ko00000	-	-	-	HTH_42
HKD2_k127_5243235_2	203119.Cthe_2608	6.153e-111	361.0	COG0055@1|root,COG0055@2|Bacteria,1TPGF@1239|Firmicutes,2489W@186801|Clostridia,3WGVH@541000|Ruminococcaceae	186801|Clostridia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits	atpD	-	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_N
HKD2_k127_5243235_1	398512.JQKC01000002_gene2002	9.042e-115	376.0	COG0224@1|root,COG0224@2|Bacteria,1TPBX@1239|Firmicutes,2486Q@186801|Clostridia,3WHJU@541000|Ruminococcaceae	186801|Clostridia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex	atpG	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt
HKD2_k127_5243235_0	398512.JQKC01000002_gene2001	6.859e-213	666.0	COG0056@1|root,COG0056@2|Bacteria,1TNZ8@1239|Firmicutes,248IY@186801|Clostridia,3WGXD@541000|Ruminococcaceae	186801|Clostridia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	atpA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
HKD2_k127_5253140_0	398512.JQKC01000023_gene3275	3.43e-192	619.0	COG0539@1|root,COG0761@1|root,COG0539@2|Bacteria,COG0761@2|Bacteria,1TQ9N@1239|Firmicutes,247UK@186801|Clostridia,3WGII@541000|Ruminococcaceae	186801|Clostridia	IJM	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis	ispH	-	1.17.7.4	ko:K02945,ko:K03527	ko00900,ko01100,ko01110,ko01130,ko03010,map00900,map01100,map01110,map01130,map03010	M00096,M00178	R05884,R08210	RC01137,RC01487	br01610,ko00000,ko00001,ko00002,ko01000,ko03011	-	-	-	LYTB,S1
HKD2_k127_5253140_3	293826.Amet_2626	9.765e-51	186.0	COG0204@1|root,COG0204@2|Bacteria,1U8N2@1239|Firmicutes,25B02@186801|Clostridia,36W9A@31979|Clostridiaceae	186801|Clostridia	I	Phosphate acyltransferases	plsC	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
HKD2_k127_5253140_2	1511.CLOST_1468	7.142e-64	226.0	COG0283@1|root,COG0283@2|Bacteria,1V3IA@1239|Firmicutes,24HEF@186801|Clostridia,25RAW@186804|Peptostreptococcaceae	186801|Clostridia	F	Belongs to the cytidylate kinase family. Type 1 subfamily	cmk	-	2.7.4.25	ko:K00945	ko00240,ko01100,map00240,map01100	M00052	R00158,R00512,R01665	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytidylate_kin
HKD2_k127_5253140_4	941824.TCEL_00212	7.296e-33	130.0	COG4401@1|root,COG4401@2|Bacteria,1VAID@1239|Firmicutes,24N1H@186801|Clostridia,36KU9@31979|Clostridiaceae	186801|Clostridia	E	Catalyzes the Claisen rearrangement of chorismate to prephenate. Probably involved in the aromatic amino acid biosynthesis	aroH	-	5.4.99.5	ko:K06208	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024,M00025	R01715	RC03116	ko00000,ko00001,ko00002,ko01000	-	-	-	CM_1
HKD2_k127_5253140_5	1094508.Tsac_1878	1.183e-08	63.0	2E93S@1|root,333CP@2|Bacteria,1VJ6S@1239|Firmicutes,24TK5@186801|Clostridia,42H9J@68295|Thermoanaerobacterales	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5253140_1	1031288.AXAA01000007_gene839	6.812e-121	395.0	COG2081@1|root,COG2081@2|Bacteria,1TQ6E@1239|Firmicutes,247S5@186801|Clostridia,36E7B@31979|Clostridiaceae	186801|Clostridia	S	HI0933 family	-	-	-	ko:K07007	-	-	-	-	ko00000	-	-	-	HI0933_like
HKD2_k127_5255237_4	1321778.HMPREF1982_02389	4.059e-67	229.0	COG1175@1|root,COG1175@2|Bacteria,1UYC1@1239|Firmicutes,24BBJ@186801|Clostridia	186801|Clostridia	G	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
HKD2_k127_5255237_2	1321778.HMPREF1982_02390	1.196e-142	457.0	COG0395@1|root,COG0395@2|Bacteria,1TR0I@1239|Firmicutes,24AZD@186801|Clostridia,269UU@186813|unclassified Clostridiales	186801|Clostridia	G	ABC transporter, permease protein	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
HKD2_k127_5255237_0	1321778.HMPREF1982_02391	0.0	1232.0	COG1554@1|root,COG1554@2|Bacteria,1TQMB@1239|Firmicutes,247J6@186801|Clostridia	186801|Clostridia	G	hydrolase, family 65, central catalytic	-	-	2.4.1.8	ko:K00691	ko00500,ko01100,map00500,map01100	-	R01555	RC00049	ko00000,ko00001,ko01000	-	GH65	-	Glyco_hydro_65C,Glyco_hydro_65N,Glyco_hydro_65m
HKD2_k127_5255237_1	1321778.HMPREF1982_02392	0.0	1148.0	COG1554@1|root,COG1554@2|Bacteria,1TQMB@1239|Firmicutes,247J6@186801|Clostridia	186801|Clostridia	G	hydrolase, family 65, central catalytic	-	GO:0003674,GO:0003824,GO:0004645,GO:0016740,GO:0016757,GO:0016758	2.4.1.279,2.4.1.332	ko:K18783,ko:K21355	-	-	R09941	RC00049	ko00000,ko01000	-	GH65	-	Glyco_hydro_65C,Glyco_hydro_65N,Glyco_hydro_65m
HKD2_k127_5255237_3	1195236.CTER_1116	6.459e-98	323.0	COG0637@1|root,COG0637@2|Bacteria,1UZE0@1239|Firmicutes,24DWR@186801|Clostridia	186801|Clostridia	S	Haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED	pgmB	-	5.4.2.6	ko:K01838	ko00500,map00500	-	R02728,R11310	RC00408	ko00000,ko00001,ko01000	-	-	-	HAD_2
HKD2_k127_5267391_17	1304880.JAGB01000001_gene618	8.375e-13	69.0	COG3383@1|root,COG4624@1|root,COG3383@2|Bacteria,COG4624@2|Bacteria,1TP6C@1239|Firmicutes,24897@186801|Clostridia	186801|Clostridia	C	hydrogenase large subunit	-	-	1.12.1.3,1.6.5.3	ko:K00336,ko:K18332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fe_hyd_SSU,Fe_hyd_lg_C,Fer2_4,Fer4,Fer4_6,Fer4_7,NADH-G_4Fe-4S_3
HKD2_k127_5267391_7	273068.TTE1073	1.423e-120	397.0	COG0502@1|root,COG0502@2|Bacteria,1TPYQ@1239|Firmicutes,248H8@186801|Clostridia,42ERD@68295|Thermoanaerobacterales	186801|Clostridia	C	SMART Elongator protein 3 MiaB NifB	hydE	-	2.8.1.6,5.4.99.58	ko:K01012,ko:K16180	ko00300,ko00780,ko01100,ko01120,map00300,map00780,map01100,map01120	M00123,M00573,M00577	R01078,R10010	RC00441,RC02995	ko00000,ko00001,ko00002,ko01000	-	-	-	BATS,Radical_SAM
HKD2_k127_5267391_0	1121423.JONT01000002_gene2218	1.251e-203	643.0	COG0502@1|root,COG0502@2|Bacteria,1TPEX@1239|Firmicutes,248PF@186801|Clostridia,260KD@186807|Peptococcaceae	186801|Clostridia	C	Biotin and Thiamin Synthesis associated	hydG	-	4.1.99.19	ko:K03150	ko00730,ko01100,map00730,map01100	-	R10246	RC01434,RC03095	ko00000,ko00001,ko01000	-	-	-	BATS,Radical_SAM
HKD2_k127_5267391_3	401526.TcarDRAFT_0904	3.204e-144	467.0	COG0486@1|root,COG0486@2|Bacteria,1TQA8@1239|Firmicutes,4H28K@909932|Negativicutes	909932|Negativicutes	S	maturation GTPase HydF	hydF	-	-	-	-	-	-	-	-	-	-	-	MMR_HSR1
HKD2_k127_5267391_11	273068.TTE0542	3.777e-65	231.0	COG1360@1|root,COG1360@2|Bacteria,1V8KE@1239|Firmicutes,24GQQ@186801|Clostridia,42G25@68295|Thermoanaerobacterales	186801|Clostridia	N	PFAM OmpA MotB domain protein	motB	-	-	ko:K02557	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1	-	-	MotB_plug,OmpA
HKD2_k127_5267391_10	580327.Tthe_2152	7.327e-82	280.0	COG1291@1|root,COG1291@2|Bacteria,1TRH1@1239|Firmicutes,24AEJ@186801|Clostridia,42F25@68295|Thermoanaerobacterales	186801|Clostridia	U	PFAM MotA TolQ ExbB proton channel	motA	-	-	ko:K02556	ko02020,ko02030,ko02040,map02020,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1	-	-	MotA_ExbB
HKD2_k127_5267391_6	1123288.SOV_1c08130	1.442e-121	396.0	COG1143@1|root,COG2878@1|root,COG1143@2|Bacteria,COG2878@2|Bacteria,1TQGD@1239|Firmicutes,4H3M6@909932|Negativicutes	909932|Negativicutes	C	electron transport complex, RnfABCDGE type, B subunit	rnfB	-	-	ko:K03616	-	-	-	-	ko00000	-	-	-	FeS,Fer4,Fer4_6,Fer4_7,Fer4_9
HKD2_k127_5267391_8	484770.UFO1_2950	2.303e-92	306.0	COG4657@1|root,COG4657@2|Bacteria,1TS06@1239|Firmicutes,4H3QI@909932|Negativicutes	909932|Negativicutes	C	Part of a membrane complex involved in electron transport	rnfA	-	-	ko:K03617	-	-	-	-	ko00000	-	-	-	Rnf-Nqr
HKD2_k127_5267391_9	1196322.A370_01182	1.689e-85	287.0	COG4660@1|root,COG4660@2|Bacteria,1TSE7@1239|Firmicutes,24972@186801|Clostridia,36F7B@31979|Clostridiaceae	186801|Clostridia	C	Part of a membrane complex involved in electron transport	rnfE	-	-	ko:K03613	-	-	-	-	ko00000	-	-	iHN637.CLJU_RS05585	Rnf-Nqr
HKD2_k127_5267391_12	1196322.A370_01181	2.114e-64	226.0	COG4659@1|root,COG4659@2|Bacteria,1V7R1@1239|Firmicutes,24JVM@186801|Clostridia,36K2X@31979|Clostridiaceae	186801|Clostridia	C	Part of a membrane complex involved in electron transport	rnfG	-	-	ko:K03612	-	-	-	-	ko00000	-	-	-	FMN_bind
HKD2_k127_5267391_2	931276.Cspa_c06820	5.661e-156	498.0	COG4658@1|root,COG4658@2|Bacteria,1TQAY@1239|Firmicutes,247TM@186801|Clostridia,36FI0@31979|Clostridiaceae	186801|Clostridia	C	Part of a membrane complex involved in electron transport	rnfD	-	-	ko:K03614	-	-	-	-	ko00000	-	-	-	NQR2_RnfD_RnfE
HKD2_k127_5267391_1	431943.CKL_1264	4.605e-200	631.0	COG4656@1|root,COG4656@2|Bacteria,1TPCC@1239|Firmicutes,24805@186801|Clostridia,36F8C@31979|Clostridiaceae	186801|Clostridia	C	Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily	rnfC	-	-	ko:K03615	-	-	-	-	ko00000	-	-	-	Complex1_51K,Fer4,Fer4_10,Fer4_7,Fer4_9,RnfC_N,SLBB
HKD2_k127_5267391_15	431943.CKL_1263	2.657e-28	119.0	COG3086@1|root,COG3086@2|Bacteria,1VEYP@1239|Firmicutes,24R8Z@186801|Clostridia,36JZI@31979|Clostridiaceae	186801|Clostridia	T	PFAM Positive regulator of sigma(E) RseC MucC	-	-	-	ko:K03803	-	-	-	-	ko00000,ko03021	-	-	-	RseC_MucC
HKD2_k127_5267391_13	398512.JQKC01000007_gene1177	1.422e-62	219.0	COG0521@1|root,COG0521@2|Bacteria,1V3XM@1239|Firmicutes,24HG2@186801|Clostridia,3WHT9@541000|Ruminococcaceae	186801|Clostridia	H	Molybdenum cofactor synthesis domain protein	mog	-	-	-	-	-	-	-	-	-	-	-	MOSC,MoCF_biosynth
HKD2_k127_5267391_14	332101.JIBU02000026_gene2922	2.182e-59	210.0	COG0315@1|root,COG0315@2|Bacteria,1V3J4@1239|Firmicutes,24H9F@186801|Clostridia,36J0W@31979|Clostridiaceae	186801|Clostridia	H	Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)	moaC	-	4.6.1.17	ko:K03637	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R11372	RC03425	ko00000,ko00001,ko01000	-	-	-	MoaC
HKD2_k127_5267391_5	1121428.DESHY_110386___1	8.22e-132	449.0	COG5001@1|root,COG5001@2|Bacteria,1TP8V@1239|Firmicutes,247PX@186801|Clostridia,26021@186807|Peptococcaceae	186801|Clostridia	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GAF_2,GGDEF,PAS_4
HKD2_k127_5267391_4	1071073.KI530537_gene1433	5.421e-135	438.0	COG1363@1|root,COG1363@2|Bacteria,1TS74@1239|Firmicutes,4HDEK@91061|Bacilli,1ZCKS@1386|Bacillus	91061|Bacilli	G	M42 glutamyl aminopeptidase	ysdC_3	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	Peptidase_M42
HKD2_k127_5267391_16	398512.JQKC01000002_gene1761	8.172e-28	113.0	COG0459@1|root,COG0459@2|Bacteria,1TP1T@1239|Firmicutes,248BG@186801|Clostridia,3WGUG@541000|Ruminococcaceae	186801|Clostridia	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
HKD2_k127_5276943_1	632292.Calhy_2344	7.35e-27	115.0	COG1172@1|root,COG1172@2|Bacteria,1V9PU@1239|Firmicutes,24PGN@186801|Clostridia	186801|Clostridia	G	Branched-chain amino acid transport system / permease component	-	-	-	ko:K10440	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	BPD_transp_2
HKD2_k127_5276943_0	632292.Calhy_2345	3.993e-47	184.0	COG1609@1|root,COG1609@2|Bacteria,1UZFZ@1239|Firmicutes,24H13@186801|Clostridia	186801|Clostridia	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5276943_2	632292.Calhy_2346	5.792e-06	49.0	COG1172@1|root,COG1172@2|Bacteria,1U0FI@1239|Firmicutes,24KVA@186801|Clostridia	186801|Clostridia	G	Branched-chain amino acid transport system / permease component	-	-	-	ko:K10440	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	BPD_transp_2
HKD2_k127_5288312_1	394503.Ccel_1662	7.698e-51	182.0	COG0738@1|root,COG0738@2|Bacteria,1TPB5@1239|Firmicutes,24913@186801|Clostridia,36GA9@31979|Clostridiaceae	186801|Clostridia	G	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD2_k127_5288312_3	666686.B1NLA3E_02900	6.634e-32	134.0	COG3861@1|root,COG3861@2|Bacteria,1VD91@1239|Firmicutes,4IKV2@91061|Bacilli,1ZHRR@1386|Bacillus	91061|Bacilli	S	Domain of unknown function (DUF2382)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2382
HKD2_k127_5288312_2	332101.JIBU02000014_gene2483	4.675e-41	156.0	COG3861@1|root,COG3861@2|Bacteria,1V24Q@1239|Firmicutes,24H5M@186801|Clostridia,36I70@31979|Clostridiaceae	186801|Clostridia	S	Domain of unknown function (DUF2382)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2382
HKD2_k127_5288312_0	1540257.JQMW01000014_gene60	1.099e-284	885.0	COG1193@1|root,COG1193@2|Bacteria,1TQWB@1239|Firmicutes,24A15@186801|Clostridia,36F5M@31979|Clostridiaceae	186801|Clostridia	L	Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity	mutS5	-	-	ko:K07456	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_V
HKD2_k127_5290368_4	994573.T472_0206090	1.357e-21	94.0	COG0468@1|root,COG0468@2|Bacteria,1TPD5@1239|Firmicutes,247SF@186801|Clostridia,36DUE@31979|Clostridiaceae	186801|Clostridia	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage	recA	-	-	ko:K03553	ko03440,map03440	M00729	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	RecA
HKD2_k127_5290368_3	573061.Clocel_3228	1.817e-25	108.0	2EGK5@1|root,33ACA@2|Bacteria,1VNI2@1239|Firmicutes,24UYH@186801|Clostridia,36PKM@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5290368_1	1294142.CINTURNW_3373	1.633e-137	443.0	COG3153@1|root,COG3153@2|Bacteria,1V5J7@1239|Firmicutes,24QAU@186801|Clostridia,36MBU@31979|Clostridiaceae	186801|Clostridia	S	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HKD2_k127_5290368_0	526218.Sterm_0789	2.466e-181	571.0	COG0402@1|root,COG0402@2|Bacteria,379QY@32066|Fusobacteria	32066|Fusobacteria	F	Amidohydrolase family	-	-	3.5.4.1	ko:K01485	ko00240,ko00330,ko01100,map00240,map00330,map01100	-	R00974,R01411,R02922	RC00074,RC00514,RC00809	ko00000,ko00001,ko01000	-	-	-	Amidohydro_3
HKD2_k127_5300322_0	1304284.L21TH_0142	2.823e-163	528.0	COG1404@1|root,COG5492@1|root,COG1404@2|Bacteria,COG5492@2|Bacteria,1TPH1@1239|Firmicutes,25EBB@186801|Clostridia,36DW5@31979|Clostridiaceae	186801|Clostridia	O	Belongs to the peptidase S8 family	-	-	3.4.21.96	ko:K01361	-	-	-	-	ko00000,ko01000,ko01002,ko03110	-	-	-	Big_3_2,Cadherin-like,Inhibitor_I9,PA,Peptidase_S8,fn3_5
HKD2_k127_5300322_4	1120998.AUFC01000034_gene1354	6.843e-43	162.0	COG4708@1|root,COG4708@2|Bacteria,1V9YK@1239|Firmicutes,24N9H@186801|Clostridia,3WCMC@538999|Clostridiales incertae sedis	186801|Clostridia	S	QueT transporter	queT	-	-	-	-	-	-	-	-	-	-	-	QueT
HKD2_k127_5300322_3	1410653.JHVC01000002_gene4379	3.581e-51	188.0	COG2968@1|root,COG2968@2|Bacteria,1VB7C@1239|Firmicutes,24MYD@186801|Clostridia,36IF7@31979|Clostridiaceae	186801|Clostridia	S	Protein of unknown function (DUF541)	-	-	-	ko:K09807	-	-	-	-	ko00000	-	-	-	SIMPL
HKD2_k127_5300322_1	1408422.JHYF01000004_gene1651	6.146e-69	242.0	COG3409@1|root,COG3773@1|root,COG3409@2|Bacteria,COG3773@2|Bacteria,1V2UK@1239|Firmicutes,24F0Y@186801|Clostridia,36HIT@31979|Clostridiaceae	186801|Clostridia	M	Cell Wall Hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_2,PG_binding_1
HKD2_k127_5300322_2	941824.TCEL_01571	7.911e-64	223.0	COG2195@1|root,COG2195@2|Bacteria,1TQBS@1239|Firmicutes,24860@186801|Clostridia,36DNZ@31979|Clostridiaceae	186801|Clostridia	E	aminoacyl-histidine dipeptidase	pepD	-	-	ko:K01270	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20
HKD2_k127_5322621_1	357809.Cphy_2756	1.761e-51	184.0	COG1670@1|root,COG1670@2|Bacteria	2|Bacteria	J	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins	-	-	2.3.1.82	ko:K18816	-	-	-	-	br01600,ko00000,ko01000,ko01504	-	-	-	Acetyltransf_1,Acetyltransf_3
HKD2_k127_5322621_2	555088.DealDRAFT_2824	1.297e-48	180.0	2ECWI@1|root,336TS@2|Bacteria,1VGT0@1239|Firmicutes	1239|Firmicutes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5322621_0	573061.Clocel_0883	1.524e-118	387.0	COG2227@1|root,COG2227@2|Bacteria,1VZEI@1239|Firmicutes,25EBH@186801|Clostridia,36UJC@31979|Clostridiaceae	186801|Clostridia	H	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
HKD2_k127_5322621_3	1094980.Mpsy_1554	8.249e-23	111.0	arCOG02527@1|root,arCOG02527@2157|Archaea,2Y6XK@28890|Euryarchaeota,2NAMP@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_53396_8	1304284.L21TH_1603	1.609e-07	59.0	COG2206@1|root,COG3437@1|root,COG3850@1|root,COG2206@2|Bacteria,COG3437@2|Bacteria,COG3850@2|Bacteria,1UZN2@1239|Firmicutes,25EWN@186801|Clostridia,36USS@31979|Clostridiaceae	186801|Clostridia	T	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF3369,GAF_2,HAMP,HD,HD_5,PAS_9,Reg_prop,Response_reg,Y_Y_Y,dCache_1
HKD2_k127_53396_10	202752.JL53_14690	0.0002999	44.0	29M4D@1|root,3081V@2|Bacteria,1U2N6@1239|Firmicutes,4ICAM@91061|Bacilli,26KS0@186820|Listeriaceae	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_53396_5	373903.Hore_01650	5.364e-24	104.0	2E5KP@1|root,330BT@2|Bacteria,1VGM7@1239|Firmicutes,24RRB@186801|Clostridia	186801|Clostridia	S	Protein of unknown function (DUF3243)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3243
HKD2_k127_53396_2	509191.AEDB02000081_gene2454	1.609e-69	240.0	COG4894@1|root,COG4894@2|Bacteria,1VUCV@1239|Firmicutes,250FU@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_53396_4	857293.CAAU_1059	1.888e-51	187.0	COG3945@1|root,COG3945@2|Bacteria,1V3TS@1239|Firmicutes,24HUR@186801|Clostridia,36J27@31979|Clostridiaceae	186801|Clostridia	S	Hemerythrin HHE cation binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
HKD2_k127_53396_9	478801.Ksed_06350	1.955e-05	52.0	2EI6M@1|root,33BXY@2|Bacteria,2GSTQ@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_53396_1	1121422.AUMW01000005_gene535	7.637e-119	389.0	COG3342@1|root,COG3342@2|Bacteria,1TS8U@1239|Firmicutes,24DS0@186801|Clostridia,264JQ@186807|Peptococcaceae	186801|Clostridia	S	Family of unknown function (DUF1028)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1028,PG_binding_2
HKD2_k127_53396_6	1382359.JIAL01000001_gene1945	4.235e-18	89.0	COG4319@1|root,COG4319@2|Bacteria,3Y4YW@57723|Acidobacteria,2JJHI@204432|Acidobacteriia	204432|Acidobacteriia	S	Domain of unknown function (DUF4440)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440
HKD2_k127_53396_0	1321778.HMPREF1982_04126	6.404e-122	397.0	COG0697@1|root,COG0697@2|Bacteria,1V009@1239|Firmicutes,24DF1@186801|Clostridia	186801|Clostridia	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HKD2_k127_53396_3	1227352.C173_23237	2.764e-69	246.0	COG1476@1|root,COG1476@2|Bacteria,1UMYA@1239|Firmicutes,4IU36@91061|Bacilli,2702R@186822|Paenibacillaceae	91061|Bacilli	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
HKD2_k127_5342860_2	935837.JAEK01000012_gene337	6.816e-85	285.0	COG0703@1|root,COG0703@2|Bacteria,1V25K@1239|Firmicutes,4HFS0@91061|Bacilli,1ZFAN@1386|Bacillus	91061|Bacilli	E	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_18
HKD2_k127_5342860_3	1298920.KI911353_gene3191	1.828e-52	190.0	COG0454@1|root,COG0456@2|Bacteria,1V763@1239|Firmicutes,24JMZ@186801|Clostridia	186801|Clostridia	K	Acetyltransferase, gnat family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10
HKD2_k127_5342860_1	1209989.TepiRe1_0831	5.433e-152	494.0	28PDA@1|root,2ZC59@2|Bacteria,1V36I@1239|Firmicutes,24G26@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5342860_4	536227.CcarbDRAFT_0231	5.955e-17	82.0	COG0083@1|root,COG0083@2|Bacteria,1TRWS@1239|Firmicutes,248NA@186801|Clostridia,36FBC@31979|Clostridiaceae	186801|Clostridia	F	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate	thrB	-	2.7.1.39	ko:K00872	ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230	M00018	R01771	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS03525	GHMP_kinases_C,GHMP_kinases_N
HKD2_k127_5342860_0	1033810.HLPCO_002308	9.013e-218	685.0	COG1164@1|root,COG1164@2|Bacteria	2|Bacteria	E	metalloendopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M3
HKD2_k127_5344513_1	1536775.H70737_01330	2.188e-61	218.0	COG2008@1|root,COG2008@2|Bacteria,1TPZI@1239|Firmicutes,4HAM3@91061|Bacilli,26T0P@186822|Paenibacillaceae	91061|Bacilli	E	Threonine aldolase	-	-	-	-	-	-	-	-	-	-	-	-	Beta_elim_lyase
HKD2_k127_5344513_0	86416.Clopa_0604	1.906e-223	695.0	COG1143@1|root,COG2006@1|root,COG1143@2|Bacteria,COG2006@2|Bacteria,1TRX2@1239|Firmicutes,249GX@186801|Clostridia,36GCZ@31979|Clostridiaceae	186801|Clostridia	C	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362,Fer4,Fer4_10,Fer4_7
HKD2_k127_5355230_9	1321778.HMPREF1982_00037	3.333e-23	99.0	COG0534@1|root,COG0534@2|Bacteria,1TNZN@1239|Firmicutes,247YX@186801|Clostridia,268UX@186813|unclassified Clostridiales	186801|Clostridia	V	Polysaccharide biosynthesis C-terminal domain	mepA_10	-	-	-	-	-	-	-	-	-	-	-	MatE
HKD2_k127_5355230_5	755731.Clo1100_3081	2.104e-95	321.0	COG0524@1|root,COG0524@2|Bacteria,1TPGM@1239|Firmicutes,247M1@186801|Clostridia,36DU6@31979|Clostridiaceae	186801|Clostridia	G	PfkB family	-	-	2.7.1.4	ko:K00847	ko00051,ko00500,ko00520,ko01100,map00051,map00500,map00520,map01100	-	R00760,R00867,R03920	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
HKD2_k127_5355230_7	1235792.C808_02764	1.983e-65	230.0	COG3822@1|root,COG3822@2|Bacteria,1UXBF@1239|Firmicutes,249XW@186801|Clostridia,27J4D@186928|unclassified Lachnospiraceae	186801|Clostridia	S	Pfam:DUF1498	-	-	-	-	-	-	-	-	-	-	-	-	Lyx_isomer
HKD2_k127_5355230_10	1226325.HMPREF1548_05569	3.323e-21	100.0	COG3934@1|root,COG3934@2|Bacteria,1UQXI@1239|Firmicutes,255N5@186801|Clostridia	186801|Clostridia	G	Belongs to the glycosyl hydrolase 5 (cellulase A) family	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5355230_6	1087481.AGFX01000012_gene3073	2.8e-70	239.0	COG2764@1|root,COG2764@2|Bacteria,1V3WE@1239|Firmicutes,4HHHS@91061|Bacilli,26XJK@186822|Paenibacillaceae	91061|Bacilli	S	Glyoxalase	phnB7	-	-	ko:K04750	-	-	-	-	ko00000	-	-	-	3-dmu-9_3-mt
HKD2_k127_5355230_4	931276.Cspa_c39430	6.873e-96	327.0	COG2199@1|root,COG2199@2|Bacteria,1V04Z@1239|Firmicutes,24A7E@186801|Clostridia,36F6P@31979|Clostridiaceae	186801|Clostridia	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
HKD2_k127_5355230_11	1304284.L21TH_1262	3.962e-10	66.0	COG5416@1|root,COG5416@2|Bacteria,1VK4W@1239|Firmicutes,24RJX@186801|Clostridia,36NC1@31979|Clostridiaceae	186801|Clostridia	S	Lipopolysaccharide assembly protein A domain	-	-	-	-	-	-	-	-	-	-	-	-	LapA_dom
HKD2_k127_5355230_2	768710.DesyoDRAFT_2706	2.647e-151	484.0	COG2908@1|root,COG2908@2|Bacteria,1TT6N@1239|Firmicutes,24A8X@186801|Clostridia,25ZZZ@186807|Peptococcaceae	186801|Clostridia	S	Calcineurin-like phosphoesterase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos,Metallophos_2
HKD2_k127_5355230_3	1321778.HMPREF1982_03634	1.77e-111	370.0	2C69W@1|root,2Z7HR@2|Bacteria,1TQNN@1239|Firmicutes,249G5@186801|Clostridia	186801|Clostridia	S	Domain of unknown function (DUF4474)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4474
HKD2_k127_5355230_0	1347086.CCBA010000044_gene2388	8.888e-289	896.0	COG0465@1|root,COG0465@2|Bacteria,1TPTV@1239|Firmicutes,4HFB3@91061|Bacilli,1ZDPF@1386|Bacillus	91061|Bacilli	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	-	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
HKD2_k127_5355230_8	1347086.CCBA010000044_gene2389	8.155e-39	149.0	COG1846@1|root,COG1846@2|Bacteria,1TUIE@1239|Firmicutes,4HH31@91061|Bacilli,1ZJBA@1386|Bacillus	91061|Bacilli	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	MarR
HKD2_k127_5355230_1	536232.CLM_1759	6.949e-204	664.0	COG2199@1|root,COG2206@1|root,COG2199@2|Bacteria,COG2206@2|Bacteria,1V6WM@1239|Firmicutes,24FPG@186801|Clostridia,36USB@31979|Clostridiaceae	186801|Clostridia	T	metal-dependent phosphohydrolase, HD sub domain	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,HD,HD_5,PAS,PAS_4,PAS_8,PAS_9
HKD2_k127_5356207_9	1297617.JPJD01000060_gene2597	4.456e-40	152.0	COG2333@1|root,COG2333@2|Bacteria,1TS9U@1239|Firmicutes,249VR@186801|Clostridia,268TI@186813|unclassified Clostridiales	186801|Clostridia	S	Metallo-beta-lactamase superfamily	-	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Ada_Zn_binding,Lactamase_B
HKD2_k127_5356207_13	1295642.H839_15863	1.105e-17	84.0	2DR1Y@1|root,339TZ@2|Bacteria,1VK7M@1239|Firmicutes,4HR6A@91061|Bacilli,1WHN9@129337|Geobacillus	91061|Bacilli	S	Protein of unknown function (DUF3006)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3006
HKD2_k127_5356207_14	471881.PROPEN_02140	1.607e-14	84.0	COG4974@1|root,COG4974@2|Bacteria,1MVNF@1224|Proteobacteria,1RPI8@1236|Gammaproteobacteria,3Z143@583|Proteus	1236|Gammaproteobacteria	D	Phage integrase, N-terminal SAM-like domain	xerD	GO:0000150,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006276,GO:0006310,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008907,GO:0009009,GO:0009037,GO:0009314,GO:0009628,GO:0009987,GO:0015074,GO:0032991,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0071139,GO:0071704,GO:0090304,GO:0140097,GO:1901360	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
HKD2_k127_5356207_1	1304284.L21TH_0317	6.722e-177	572.0	COG0840@1|root,COG0840@2|Bacteria,1TP5A@1239|Firmicutes,247S3@186801|Clostridia,36GR1@31979|Clostridiaceae	186801|Clostridia	T	chemotaxis protein	mcpC3	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	HAMP,MCPsignal,dCache_1,sCache_2
HKD2_k127_5356207_11	768710.DesyoDRAFT_3388	3.131e-35	143.0	2EUBA@1|root,33MTN@2|Bacteria,1VM49@1239|Firmicutes,24X97@186801|Clostridia,263A6@186807|Peptococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5356207_15	1280390.CBQR020000052_gene1034	5.343e-13	73.0	2ER2W@1|root,33INH@2|Bacteria,1VPMJ@1239|Firmicutes,4HZNC@91061|Bacilli,270VH@186822|Paenibacillaceae	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5356207_12	580327.Tthe_1987	5.107e-28	116.0	COG0526@1|root,COG0526@2|Bacteria,1VFUD@1239|Firmicutes,24R4Y@186801|Clostridia,42GTW@68295|Thermoanaerobacterales	186801|Clostridia	CO	PFAM Thioredoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin
HKD2_k127_5356207_3	1294142.CINTURNW_2427	9.544e-94	314.0	COG0454@1|root,COG0456@2|Bacteria,1VSXJ@1239|Firmicutes,24YN7@186801|Clostridia	186801|Clostridia	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HKD2_k127_5356207_7	768706.Desor_1854	4.586e-58	203.0	COG0251@1|root,COG0251@2|Bacteria,1VD2R@1239|Firmicutes,24IJD@186801|Clostridia,2655D@186807|Peptococcaceae	186801|Clostridia	J	Endoribonuclease L-PSP	-	-	3.5.99.10	ko:K09022	-	-	R11098,R11099	RC03275,RC03354	ko00000,ko01000	-	-	-	Ribonuc_L-PSP
HKD2_k127_5356207_16	1304284.L21TH_2317	2.823e-05	53.0	2DDBW@1|root,2ZHFR@2|Bacteria,1W60N@1239|Firmicutes,254ME@186801|Clostridia,36U1H@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5356207_4	1121335.Clst_2381	3.593e-68	235.0	COG0778@1|root,COG0778@2|Bacteria,1V4DP@1239|Firmicutes,24HBZ@186801|Clostridia,3WK3U@541000|Ruminococcaceae	186801|Clostridia	C	nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	DUF1905,Nitroreductase
HKD2_k127_5356207_10	1294142.CINTURNW_1192	1.931e-38	145.0	2DMPW@1|root,32SY6@2|Bacteria,1VAXG@1239|Firmicutes,24MNR@186801|Clostridia,36KF1@31979|Clostridiaceae	186801|Clostridia	S	Protein of unknown function (DUF3795)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3795
HKD2_k127_5356207_5	592027.CLG_B1658	6.753e-63	233.0	COG2720@1|root,COG2720@2|Bacteria,1TSH8@1239|Firmicutes,2493X@186801|Clostridia,36EIZ@31979|Clostridiaceae	186801|Clostridia	V	PFAM VanW family protein	vanW	-	-	ko:K18346	ko01502,ko02020,map01502,map02020	M00651	-	-	ko00000,ko00001,ko00002,ko01504	-	-	-	G5,PG_binding_4,VanW
HKD2_k127_5356207_8	1487921.DP68_05765	1.656e-40	153.0	COG0640@1|root,COG0640@2|Bacteria,1V9KK@1239|Firmicutes,24NXW@186801|Clostridia,36JM8@31979|Clostridiaceae	186801|Clostridia	K	regulatory protein, arsR	-	-	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	HTH_5
HKD2_k127_5356207_2	1410653.JHVC01000009_gene2679	8.153e-172	544.0	COG0798@1|root,COG0798@2|Bacteria,1TRMD@1239|Firmicutes,24958@186801|Clostridia,36FGQ@31979|Clostridiaceae	186801|Clostridia	P	TIGRFAM Arsenical-resistance protein	arsB	-	-	ko:K03325	-	-	-	-	ko00000,ko02000	2.A.59	-	-	SBF
HKD2_k127_5356207_6	1499689.CCNN01000006_gene679	1.593e-58	204.0	2DMHQ@1|root,32RMG@2|Bacteria,1VB95@1239|Firmicutes,24K45@186801|Clostridia,36K8F@31979|Clostridiaceae	186801|Clostridia	S	Arsenical resistance operon trans-acting repressor ArsD	arsD	-	-	-	-	-	-	-	-	-	-	-	ArsD
HKD2_k127_5356207_0	445335.CBN_0811	9.387e-223	695.0	COG0003@1|root,COG0003@2|Bacteria,1TQZP@1239|Firmicutes,249JN@186801|Clostridia,36EXQ@31979|Clostridiaceae	186801|Clostridia	D	TIGRFAM arsenite-activated ATPase ArsA	arsA	-	3.6.3.16	ko:K01551	-	-	-	-	ko00000,ko01000,ko02000	3.A.19.1,3.A.21.1,3.A.4.1	-	-	ArsA_ATPase
HKD2_k127_5358750_5	580327.Tthe_1505	1.853e-21	98.0	COG0711@1|root,COG0711@2|Bacteria,1V97P@1239|Firmicutes,24JGQ@186801|Clostridia,42J6A@68295|Thermoanaerobacterales	186801|Clostridia	C	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5358750_2	555079.Toce_1041	2.455e-64	223.0	COG0669@1|root,COG0669@2|Bacteria,1V3MR@1239|Firmicutes,24HC3@186801|Clostridia,42GEH@68295|Thermoanaerobacterales	186801|Clostridia	H	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate	coaD	-	2.7.7.3	ko:K00954	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
HKD2_k127_5358750_3	2325.TKV_c14020	3.016e-51	187.0	COG0742@1|root,COG0742@2|Bacteria,1V3JF@1239|Firmicutes,24JHR@186801|Clostridia,42GVS@68295|Thermoanaerobacterales	186801|Clostridia	L	Methyltransferase	rsmD	-	2.1.1.171	ko:K08316	-	-	R07234	RC00003	ko00000,ko01000,ko03009	-	-	-	Cons_hypoth95
HKD2_k127_5358750_6	1280692.AUJL01000029_gene1860	7.926e-17	82.0	2BX75@1|root,32YCI@2|Bacteria,1VEDY@1239|Firmicutes,24QPW@186801|Clostridia,36MPW@31979|Clostridiaceae	186801|Clostridia	S	Small acid-soluble spore	-	-	-	-	-	-	-	-	-	-	-	-	SASP
HKD2_k127_5358750_0	1304284.L21TH_1432	5.481e-211	675.0	COG1200@1|root,COG1200@2|Bacteria,1TQ6I@1239|Firmicutes,247T0@186801|Clostridia,36EV7@31979|Clostridiaceae	186801|Clostridia	L	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)	recG	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge
HKD2_k127_5358750_1	1031288.AXAA01000001_gene2251	1.274e-177	572.0	COG1461@1|root,COG1461@2|Bacteria,1TQMX@1239|Firmicutes,247XI@186801|Clostridia,36E63@31979|Clostridiaceae	186801|Clostridia	S	DAK2 domain fusion protein YloV	yloV	-	-	ko:K07030	-	-	-	-	ko00000	-	-	-	Dak1_2,Dak2
HKD2_k127_5358750_4	1408422.JHYF01000002_gene2613	4.877e-43	160.0	COG1302@1|root,COG1302@2|Bacteria,1V731@1239|Firmicutes,24JIA@186801|Clostridia,36JGK@31979|Clostridiaceae	186801|Clostridia	S	Asp23 family, cell envelope-related function	-	-	-	-	-	-	-	-	-	-	-	-	Asp23
HKD2_k127_5360213_2	1408422.JHYF01000006_gene1226	1.14e-28	117.0	COG4466@1|root,COG4466@2|Bacteria,1VEQM@1239|Firmicutes,24QN2@186801|Clostridia,36KJC@31979|Clostridiaceae	186801|Clostridia	S	Biofilm formation stimulator VEG	veg	-	-	-	-	-	-	-	-	-	-	-	VEG
HKD2_k127_5360213_1	293826.Amet_4609	1.384e-161	520.0	COG2235@1|root,COG2235@2|Bacteria,1TQWS@1239|Firmicutes,249V9@186801|Clostridia,36DPX@31979|Clostridiaceae	186801|Clostridia	E	Arginine dihydrolase	arcA	-	3.5.3.6	ko:K01478	ko00220,ko01100,ko01110,ko01130,map00220,map01100,map01110,map01130	-	R00552	RC00177	ko00000,ko00001,ko01000	-	-	-	Amidinotransf
HKD2_k127_5360213_0	1120998.AUFC01000005_gene631	1.882e-182	573.0	COG0078@1|root,COG0078@2|Bacteria,1TPF2@1239|Firmicutes,248I5@186801|Clostridia,3WCFU@538999|Clostridiales incertae sedis	186801|Clostridia	E	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline	argF	-	2.1.3.3	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844	R01398	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS12430	OTCace,OTCace_N
HKD2_k127_5361017_6	44251.PDUR_13735	1.673e-10	63.0	COG2227@1|root,COG2227@2|Bacteria,1TSTX@1239|Firmicutes,4ISD1@91061|Bacilli,26QI5@186822|Paenibacillaceae	91061|Bacilli	H	SAM-dependent methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
HKD2_k127_5361017_7	273068.TTE1986	4.029e-09	64.0	2ERPB@1|root,33J8P@2|Bacteria,1VM4Z@1239|Firmicutes,24V9G@186801|Clostridia,42IP8@68295|Thermoanaerobacterales	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5361017_1	941824.TCEL_01301	1.159e-59	220.0	COG0546@1|root,COG0546@2|Bacteria,1TPPZ@1239|Firmicutes,24GK6@186801|Clostridia,36IAM@31979|Clostridiaceae	186801|Clostridia	F	IA, variant 1	ppaX	-	3.1.3.18,3.6.1.1	ko:K01091,ko:K06019	ko00190,ko00630,ko01100,ko01110,ko01130,map00190,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
HKD2_k127_5361017_0	1280692.AUJL01000035_gene427	1.647e-74	257.0	COG1489@1|root,COG1489@2|Bacteria,1V1GZ@1239|Firmicutes,24A0M@186801|Clostridia,36DDK@31979|Clostridiaceae	186801|Clostridia	S	Belongs to the SfsA family	sfsA	-	-	ko:K06206	-	-	-	-	ko00000	-	-	-	SfsA
HKD2_k127_5361017_4	1230342.CTM_10186	1.024e-15	82.0	2E70J@1|root,331JD@2|Bacteria,1VGGS@1239|Firmicutes,24JJ2@186801|Clostridia,36JT3@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5361017_2	484770.UFO1_2049	6.281e-46	177.0	COG0791@1|root,COG0791@2|Bacteria,1V9ZW@1239|Firmicutes,4H4F5@909932|Negativicutes	909932|Negativicutes	M	NLP P60 protein	-	-	-	-	-	-	-	-	-	-	-	-	NLPC_P60,PG_binding_1
HKD2_k127_5361017_3	398512.JQKC01000047_gene4770	3.322e-38	147.0	COG0730@1|root,COG3339@1|root,COG0730@2|Bacteria,COG3339@2|Bacteria,1VAM6@1239|Firmicutes,24KQN@186801|Clostridia,3WKEZ@541000|Ruminococcaceae	186801|Clostridia	S	Protein of unknown function (DUF1232)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1232
HKD2_k127_5361017_5	1031288.AXAA01000008_gene1279	1.755e-14	85.0	2DMAN@1|root,32DSV@2|Bacteria,1V8JH@1239|Firmicutes,24MCY@186801|Clostridia,36JPV@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	ko:K21471	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	-
HKD2_k127_5367380_5	1094508.Tsac_1823	3.603e-48	177.0	COG0779@1|root,COG0779@2|Bacteria,1V6KT@1239|Firmicutes,24N1G@186801|Clostridia,42GU2@68295|Thermoanaerobacterales	186801|Clostridia	J	Required for maturation of 30S ribosomal subunits	rimP	-	-	ko:K09748	-	-	-	-	ko00000,ko03009	-	-	-	DUF150,DUF150_C
HKD2_k127_5367380_0	340099.Teth39_1214	0.0	1553.0	COG2176@1|root,COG2176@2|Bacteria,1TPAG@1239|Firmicutes,248YB@186801|Clostridia,42FB8@68295|Thermoanaerobacterales	186801|Clostridia	L	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity	polC	-	2.7.7.7	ko:K03763	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_a_NI,DNA_pol3_a_NII,DNA_pol3_alpha,HHH_6,PHP,RNase_T,tRNA_anti-codon
HKD2_k127_5367380_4	1128398.Curi_c15620	2.875e-74	256.0	COG1215@1|root,COG1215@2|Bacteria,1UHZ3@1239|Firmicutes,24G8E@186801|Clostridia,26B3V@186813|unclassified Clostridiales	186801|Clostridia	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HKD2_k127_5367380_1	1094508.Tsac_1820	8.407e-143	461.0	COG0821@1|root,COG0821@2|Bacteria,1TPFR@1239|Firmicutes,247N1@186801|Clostridia,42FDK@68295|Thermoanaerobacterales	186801|Clostridia	I	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate	ispG	-	1.17.7.1,1.17.7.3	ko:K03526	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R08689,R10859	RC01486	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS06430	GcpE
HKD2_k127_5367380_3	1286171.EAL2_c13280	6.328e-87	298.0	COG0750@1|root,COG0750@2|Bacteria,1TPMC@1239|Firmicutes,247MT@186801|Clostridia,25VUG@186806|Eubacteriaceae	186801|Clostridia	M	Psort location CytoplasmicMembrane, score	rseP	-	-	ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_M50
HKD2_k127_5367380_2	720554.Clocl_2460	2.876e-98	326.0	COG0743@1|root,COG0743@2|Bacteria,1TP1C@1239|Firmicutes,2483M@186801|Clostridia,3WGCN@541000|Ruminococcaceae	186801|Clostridia	I	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)	dxr	-	1.1.1.267	ko:K00099	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05688	RC01452	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS06420	DXPR_C,DXP_redisom_C,DXP_reductoisom
HKD2_k127_5368070_0	1304284.L21TH_1309	1.484e-181	578.0	COG1066@1|root,COG1066@2|Bacteria,1TQ7Y@1239|Firmicutes,247TA@186801|Clostridia,36DMV@31979|Clostridiaceae	186801|Clostridia	O	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function	radA	-	-	ko:K04485	-	-	-	-	ko00000,ko03400	-	-	-	AAA_25,ATPase,ChlI,Lon_C
HKD2_k127_5368070_1	350688.Clos_0458	3.116e-138	447.0	COG1623@1|root,COG1623@2|Bacteria,1TQD8@1239|Firmicutes,247J4@186801|Clostridia,36DQY@31979|Clostridiaceae	186801|Clostridia	L	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation	disA	-	2.7.7.85	ko:K07067	-	-	-	-	ko00000,ko01000	-	-	-	DisA-linker,DisA_N,HHH,HHH_2
HKD2_k127_5368070_2	697281.Mahau_0440	5.207e-53	189.0	COG1694@1|root,COG1694@2|Bacteria,1VBGH@1239|Firmicutes,24JEF@186801|Clostridia,42GJT@68295|Thermoanaerobacterales	186801|Clostridia	S	Mazg nucleotide pyrophosphohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5369232_0	1304284.L21TH_1533	7.216e-110	370.0	COG2182@1|root,COG2182@2|Bacteria,1UYUJ@1239|Firmicutes,24DI0@186801|Clostridia,36E4V@31979|Clostridiaceae	186801|Clostridia	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_8
HKD2_k127_5369232_2	1292035.H476_3108	2.196e-96	324.0	COG0812@1|root,COG0812@2|Bacteria,1TP3W@1239|Firmicutes,247IU@186801|Clostridia,25QY4@186804|Peptostreptococcaceae	186801|Clostridia	M	Cell wall formation	murB	-	1.3.1.98	ko:K00075	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R03191,R03192	RC02639	ko00000,ko00001,ko01000,ko01011	-	-	-	FAD_binding_4,MurB_C
HKD2_k127_5369232_3	1121289.JHVL01000013_gene1626	1.938e-78	269.0	COG1387@1|root,COG1387@2|Bacteria,1TQ33@1239|Firmicutes,24CMU@186801|Clostridia,36FPE@31979|Clostridiaceae	186801|Clostridia	E	DNA polymerase alpha chain like domain	-	-	-	ko:K04477	-	-	-	-	ko00000	-	-	-	PHP
HKD2_k127_5369232_1	350688.Clos_0574	2.275e-105	348.0	COG1660@1|root,COG1660@2|Bacteria,1TPS4@1239|Firmicutes,248KQ@186801|Clostridia,36DI8@31979|Clostridiaceae	186801|Clostridia	S	Displays ATPase and GTPase activities	yvcJ	-	-	ko:K06958	-	-	-	-	ko00000,ko03019	-	-	-	ATP_bind_2
HKD2_k127_5375211_4	521460.Athe_2247	3.656e-54	195.0	COG2323@1|root,COG2323@2|Bacteria,1V3NW@1239|Firmicutes,24H1Q@186801|Clostridia,42FAY@68295|Thermoanaerobacterales	186801|Clostridia	S	Protein of unknown function (DUF421)	-	-	-	-	-	-	-	-	-	-	-	-	DUF421
HKD2_k127_5375211_1	398512.JQKC01000026_gene3788	3.198e-148	472.0	COG0702@1|root,COG0702@2|Bacteria,1UY7W@1239|Firmicutes,24CSQ@186801|Clostridia	186801|Clostridia	GM	NmrA-like family	-	-	-	-	-	-	-	-	-	-	-	-	NmrA
HKD2_k127_5375211_5	1408422.JHYF01000008_gene3676	4.163e-49	179.0	COG1846@1|root,COG1846@2|Bacteria,1VDY5@1239|Firmicutes,24Q37@186801|Clostridia,36M8F@31979|Clostridiaceae	186801|Clostridia	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	MarR
HKD2_k127_5375211_0	1262449.CP6013_2734	7.993e-150	477.0	COG0648@1|root,COG0648@2|Bacteria,1TP1D@1239|Firmicutes,2499E@186801|Clostridia,36F6F@31979|Clostridiaceae	186801|Clostridia	L	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin	nfo	-	3.1.21.2	ko:K01151	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AP_endonuc_2
HKD2_k127_5375211_2	871968.DESME_14225	9.364e-113	370.0	COG1277@1|root,COG1277@2|Bacteria,1V6DZ@1239|Firmicutes,249IM@186801|Clostridia,261GK@186807|Peptococcaceae	186801|Clostridia	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2
HKD2_k127_5375211_3	1195236.CTER_4868	6.534e-112	366.0	COG1277@1|root,COG1277@2|Bacteria,1TRD6@1239|Firmicutes,24DIY@186801|Clostridia,3WH47@541000|Ruminococcaceae	186801|Clostridia	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2
HKD2_k127_5375211_6	398512.JQKC01000043_gene4247	4.922e-11	62.0	COG1131@1|root,COG1131@2|Bacteria,1TQHS@1239|Firmicutes,24941@186801|Clostridia,3WGCM@541000|Ruminococcaceae	186801|Clostridia	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD2_k127_5375669_3	394503.Ccel_1387	2.314e-87	291.0	2AHVT@1|root,3188J@2|Bacteria,1V8V5@1239|Firmicutes,24FT6@186801|Clostridia,36IAB@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5375669_4	394503.Ccel_1388	6.678e-83	278.0	2AHVT@1|root,3188J@2|Bacteria,1V8V5@1239|Firmicutes,24FT6@186801|Clostridia,36IAB@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5375669_5	1196029.ALIM01000014_gene3844	8.929e-62	214.0	COG4898@1|root,COG4898@2|Bacteria,1V6U6@1239|Firmicutes,4HH1D@91061|Bacilli,1ZG6X@1386|Bacillus	91061|Bacilli	S	Uncharacterized protein conserved in bacteria (DUF2200)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2200
HKD2_k127_5375669_1	398512.JQKC01000019_gene3482	2.196e-92	304.0	2EA57@1|root,334A4@2|Bacteria,1VHEA@1239|Firmicutes,24RNE@186801|Clostridia,3WQK0@541000|Ruminococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5375669_6	871968.DESME_03820	7.44e-60	208.0	COG3576@1|root,COG3576@2|Bacteria,1VC6T@1239|Firmicutes,24HPP@186801|Clostridia,2651Y@186807|Peptococcaceae	186801|Clostridia	S	Pfam:Pyridox_oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
HKD2_k127_5375669_2	768706.Desor_1849	8.315e-91	301.0	COG1959@1|root,COG1959@2|Bacteria,1V6FG@1239|Firmicutes,24ACI@186801|Clostridia,263M9@186807|Peptococcaceae	186801|Clostridia	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Rrf2
HKD2_k127_5375669_0	748727.CLJU_c17780	4.1e-107	349.0	COG0546@1|root,COG0546@2|Bacteria,1V4W6@1239|Firmicutes,24C82@186801|Clostridia,36IKK@31979|Clostridiaceae	186801|Clostridia	S	IA, variant 1	-	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
HKD2_k127_5375669_7	621372.ACIH01000195_gene2559	1.449e-07	55.0	COG1335@1|root,COG1335@2|Bacteria,1V7B8@1239|Firmicutes,4HJEA@91061|Bacilli,26WTP@186822|Paenibacillaceae	91061|Bacilli	Q	isochorismatase	-	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
HKD2_k127_5388936_5	1291050.JAGE01000001_gene2669	4.043e-35	154.0	COG1657@1|root,COG1657@2|Bacteria,1V69S@1239|Firmicutes,24FFM@186801|Clostridia	186801|Clostridia	I	S-layer homology domain	-	-	-	-	-	-	-	-	-	-	-	-	Cu_amine_oxidN1,SLH
HKD2_k127_5388936_0	1121422.AUMW01000009_gene3340	0.0	1183.0	COG1882@1|root,COG1882@2|Bacteria,1TPTF@1239|Firmicutes,247YY@186801|Clostridia,2618A@186807|Peptococcaceae	186801|Clostridia	C	Glycine radical enzyme that catalyzes the cleavage of a C-N bond in choline, producing trimethylamine (TMA) and acetaldehyde	-	-	2.3.1.54,4.3.99.4	ko:K00656,ko:K20038	ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120	-	R00212,R06987	RC00004,RC01181,RC02742,RC02833	ko00000,ko00001,ko01000	-	-	-	Gly_radical,PFL-like
HKD2_k127_5388936_4	1280692.AUJL01000002_gene2574	3.25e-105	349.0	COG1180@1|root,COG1180@2|Bacteria,1TPK2@1239|Firmicutes,24871@186801|Clostridia,36DCB@31979|Clostridiaceae	186801|Clostridia	C	glycyl-radical enzyme activating protein family	csdA	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4,Fer4_12,Radical_SAM
HKD2_k127_5388936_2	1121289.JHVL01000013_gene1640	1.637e-107	352.0	COG0410@1|root,COG0410@2|Bacteria,1TPW4@1239|Firmicutes,247PN@186801|Clostridia,36DF9@31979|Clostridiaceae	186801|Clostridia	E	ABC transporter	livF1	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
HKD2_k127_5388936_3	1121289.JHVL01000013_gene1641	3.995e-107	353.0	COG0411@1|root,COG0411@2|Bacteria,1TR0P@1239|Firmicutes,2490B@186801|Clostridia,36F00@31979|Clostridiaceae	186801|Clostridia	E	PFAM ABC transporter	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
HKD2_k127_5388936_1	1121289.JHVL01000013_gene1642	5.29e-145	467.0	COG4177@1|root,COG4177@2|Bacteria,1TPMZ@1239|Firmicutes,248WH@186801|Clostridia,36DQT@31979|Clostridiaceae	186801|Clostridia	U	Belongs to the binding-protein-dependent transport system permease family	livM	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HKD2_k127_5393905_5	1304284.L21TH_1602	2.223e-101	345.0	COG2812@1|root,COG2812@2|Bacteria,1TPS9@1239|Firmicutes,247J7@186801|Clostridia,36DBN@31979|Clostridiaceae	186801|Clostridia	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity	dnaX	-	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNA_pol3_gamma3
HKD2_k127_5393905_7	293826.Amet_4780	1.953e-41	154.0	COG0718@1|root,COG0718@2|Bacteria,1VA1S@1239|Firmicutes,24MXH@186801|Clostridia,36JG6@31979|Clostridiaceae	186801|Clostridia	S	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection	-	-	-	ko:K09747	-	-	-	-	ko00000	-	-	-	YbaB_DNA_bd
HKD2_k127_5393905_6	509191.AEDB02000034_gene2290	1.969e-95	316.0	COG0353@1|root,COG0353@2|Bacteria,1TR87@1239|Firmicutes,2487H@186801|Clostridia,3WHNZ@541000|Ruminococcaceae	186801|Clostridia	L	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO	recR	-	-	ko:K06187	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	HHH,RecR,Toprim_4
HKD2_k127_5393905_10	293826.Amet_4775	9.605e-15	77.0	2EGKS@1|root,33ACZ@2|Bacteria,1VKRW@1239|Firmicutes,24UHR@186801|Clostridia	186801|Clostridia	S	Protein of unknown function (DUF2508)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2508
HKD2_k127_5393905_9	1128398.Curi_c01030	2.937e-18	87.0	2DRM3@1|root,33C8V@2|Bacteria,1VKUE@1239|Firmicutes,24RNH@186801|Clostridia,26C2M@186813|unclassified Clostridiales	186801|Clostridia	S	SigmaK-factor processing regulatory protein BofA	bofA	-	-	ko:K06317	-	-	-	-	ko00000	-	-	-	BofA
HKD2_k127_5393905_0	1304284.L21TH_1534	0.0	1870.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1143@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1143@2|Bacteria,1TQJ2@1239|Firmicutes,248FW@186801|Clostridia,36EA6@31979|Clostridiaceae	186801|Clostridia	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	nifJ	-	1.2.7.1	ko:K03737	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00173,M00307	R01196,R10866	RC00004,RC02742	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	EKR,Fer4_16,Fer4_7,PFOR_II,POR,POR_N,TPP_enzyme_C
HKD2_k127_5393905_3	1321778.HMPREF1982_01228	7.814e-134	453.0	COG0840@1|root,COG0840@2|Bacteria,1TP5A@1239|Firmicutes,247S3@186801|Clostridia,26AKV@186813|unclassified Clostridiales	186801|Clostridia	NT	Pfam:Cache_1	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	MCPsignal,dCache_1,sCache_2
HKD2_k127_5393905_4	203119.Cthe_2390	1.33e-103	338.0	COG1014@1|root,COG1014@2|Bacteria,1TRFJ@1239|Firmicutes,24A29@186801|Clostridia,3WHD7@541000|Ruminococcaceae	186801|Clostridia	C	oxidoreductase, gamma subunit	porC	-	1.2.7.1	ko:K00172	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR
HKD2_k127_5393905_8	1304880.JAGB01000004_gene1408	1.886e-40	152.0	COG1144@1|root,COG1144@2|Bacteria,1VAAJ@1239|Firmicutes,24NFD@186801|Clostridia	186801|Clostridia	C	2-oxoacid acceptor oxidoreductase, delta subunit, pyruvate 2-ketoisovalerate family	porD	-	1.2.7.1	ko:K00171	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4
HKD2_k127_5393905_1	608506.COB47_0809	1.358e-193	609.0	COG0674@1|root,COG0674@2|Bacteria,1VS48@1239|Firmicutes,25E5U@186801|Clostridia,42EUF@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM pyruvate flavodoxin ferredoxin oxidoreductase domain protein	porA	-	1.2.7.1	ko:K00169	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
HKD2_k127_5393905_2	332101.JIBU02000027_gene2886	7.564e-171	539.0	COG1013@1|root,COG1013@2|Bacteria,1TPF0@1239|Firmicutes,24BE5@186801|Clostridia,36EUP@31979|Clostridiaceae	186801|Clostridia	C	ferredoxin oxidoreductase	porB	-	1.2.7.1	ko:K00170	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
HKD2_k127_5397357_2	86416.Clopa_2025	5.696e-73	251.0	COG1388@1|root,COG1388@2|Bacteria,1V4FC@1239|Firmicutes,24CPD@186801|Clostridia,36GV9@31979|Clostridiaceae	186801|Clostridia	M	LysM domain	-	-	-	-	-	-	-	-	-	-	-	-	LysM
HKD2_k127_5397357_0	1321778.HMPREF1982_02545	2.219e-144	465.0	COG0697@1|root,COG0697@2|Bacteria,1TPST@1239|Firmicutes,248K5@186801|Clostridia	186801|Clostridia	EG	PFAM EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HKD2_k127_5397357_1	573061.Clocel_0290	7.704e-91	306.0	COG1708@1|root,COG1708@2|Bacteria,1V2AN@1239|Firmicutes,24W5N@186801|Clostridia	186801|Clostridia	S	Domain of unknown function (DUF4111)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4111
HKD2_k127_5399765_9	1304875.JAFZ01000001_gene1948	4.134e-41	152.0	COG0662@1|root,COG0662@2|Bacteria	2|Bacteria	G	Cupin 2, conserved barrel domain protein	-	-	-	ko:K21700	-	-	-	-	ko00000	-	-	-	Cupin_2,HTH_18,HTH_AraC
HKD2_k127_5399765_7	1230342.CTM_00725	1.647e-46	169.0	COG2076@1|root,COG2076@2|Bacteria,1VEZX@1239|Firmicutes,24JMC@186801|Clostridia,36K9A@31979|Clostridiaceae	186801|Clostridia	P	Small Multidrug Resistance protein	-	-	-	ko:K11741	-	-	-	-	ko00000,ko02000	2.A.7.1	-	-	Multi_Drug_Res
HKD2_k127_5399765_3	1487921.DP68_01740	3.311e-111	363.0	COG0731@1|root,COG0731@2|Bacteria,1V1JJ@1239|Firmicutes,25DKG@186801|Clostridia,36FHY@31979|Clostridiaceae	186801|Clostridia	C	Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
HKD2_k127_5399765_0	641107.CDLVIII_5356	4.783e-188	593.0	COG0626@1|root,COG0626@2|Bacteria,1TPC7@1239|Firmicutes,25E6I@186801|Clostridia,36DC8@31979|Clostridiaceae	186801|Clostridia	E	PFAM Cys Met metabolism	metC	-	4.4.1.8	ko:K01760	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R00782,R01286,R02408,R04941	RC00056,RC00069,RC00382,RC00488,RC00710,RC01245,RC02303	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS11995	Cys_Met_Meta_PP
HKD2_k127_5399765_10	536232.CLM_0867	0.0007318	42.0	COG1854@1|root,COG1854@2|Bacteria,1V1CH@1239|Firmicutes,24G3R@186801|Clostridia,36I3G@31979|Clostridiaceae	186801|Clostridia	H	Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD)	luxS	-	4.4.1.21	ko:K07173	ko00270,ko01100,ko01230,ko02024,ko02026,ko05111,map00270,map01100,map01230,map02024,map02026,map05111	M00609	R01291	RC00069,RC01929	ko00000,ko00001,ko00002,ko01000	-	-	-	LuxS
HKD2_k127_5399765_4	1294142.CINTURNW_3437	1.418e-106	353.0	COG1606@1|root,COG1606@2|Bacteria,1TPB2@1239|Firmicutes,2485J@186801|Clostridia,36DE3@31979|Clostridiaceae	186801|Clostridia	S	TIGRFAM TIGR00268 family protein	-	-	-	ko:K06864	-	-	-	-	ko00000	-	-	-	ATP_bind_3,NAD_synthase,QueC
HKD2_k127_5399765_8	994573.T472_0200370	4.625e-46	172.0	COG1246@1|root,COG1246@2|Bacteria,1V9D3@1239|Firmicutes,24DYK@186801|Clostridia,36HXT@31979|Clostridiaceae	186801|Clostridia	E	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HKD2_k127_5399765_6	293826.Amet_1125	9.927e-58	201.0	COG1917@1|root,COG1917@2|Bacteria,1V6IB@1239|Firmicutes,24JTU@186801|Clostridia,36JXK@31979|Clostridiaceae	186801|Clostridia	S	PFAM Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HKD2_k127_5399765_1	1487921.DP68_02115	7.648e-142	459.0	2DBR0@1|root,2ZAHN@2|Bacteria,1U2KE@1239|Firmicutes,25K7U@186801|Clostridia,36PK3@31979|Clostridiaceae	186801|Clostridia	S	Sigma factor regulator C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	Sigma_reg_C
HKD2_k127_5399765_5	1294142.CINTURNW_4212	4.142e-69	239.0	COG1595@1|root,COG1595@2|Bacteria,1VE7P@1239|Firmicutes,25BYX@186801|Clostridia	186801|Clostridia	K	Sigma-70, region 4	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD2_k127_5399765_2	1033810.HLPCO_002956	5.526e-137	441.0	COG3153@1|root,COG3153@2|Bacteria	2|Bacteria	S	transferase activity, transferring acyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HKD2_k127_5415414_3	1347369.CCAD010000076_gene3373	9.175e-82	276.0	COG0765@1|root,COG0765@2|Bacteria,1TPQ8@1239|Firmicutes,4H9N1@91061|Bacilli,1ZBG5@1386|Bacillus	91061|Bacilli	P	COG0765 ABC-type amino acid transport system, permease component	tcyB	-	-	ko:K10009	ko02010,map02010	M00234	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3.10,3.A.1.3.14	-	-	BPD_transp_1
HKD2_k127_5415414_2	1487921.DP68_03385	4.841e-114	373.0	COG0834@1|root,COG0834@2|Bacteria,1TQNR@1239|Firmicutes,249Y5@186801|Clostridia,36DVN@31979|Clostridiaceae	186801|Clostridia	ET	Belongs to the bacterial solute-binding protein 3 family	-	-	-	ko:K02030,ko:K02424	ko02010,map02010	M00234,M00236	-	-	ko00000,ko00001,ko00002,ko02000,ko02035	3.A.1.3,3.A.1.3.10,3.A.1.3.14	-	-	SBP_bac_3
HKD2_k127_5415414_1	445335.CBN_2005	5.114e-254	797.0	COG3284@1|root,COG3284@2|Bacteria,1VHQN@1239|Firmicutes,25EB0@186801|Clostridia,36UIY@31979|Clostridiaceae	186801|Clostridia	KQ	Sigma54 specific transcriptional regulator, Fis family	aorR	-	-	ko:K21405	-	-	-	-	ko00000,ko03000	-	-	-	GAF,HTH_8,PAS,PAS_8,PAS_9,Sigma54_activat
HKD2_k127_5415414_0	340099.Teth39_0850	1.898e-263	819.0	COG2414@1|root,COG2414@2|Bacteria,1TPT9@1239|Firmicutes,2481Q@186801|Clostridia,42ERP@68295|Thermoanaerobacterales	186801|Clostridia	C	Aldehyde ferredoxin oxidoreductase	aor	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS09915	AFOR_C,AFOR_N
HKD2_k127_5428381_0	203119.Cthe_2174	2.369e-180	576.0	COG1158@1|root,COG1158@2|Bacteria,1TPHZ@1239|Firmicutes,247YK@186801|Clostridia,3WGZQ@541000|Ruminococcaceae	186801|Clostridia	K	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template	rho	-	-	ko:K03628	ko03018,map03018	-	-	-	ko00000,ko00001,ko03019,ko03021	-	-	-	ATP-synt_ab,Rho_N,Rho_RNA_bind
HKD2_k127_5428381_3	1121335.Clst_2187	1.675e-30	121.0	COG0254@1|root,COG0254@2|Bacteria,1VEGU@1239|Firmicutes,24QNZ@186801|Clostridia	186801|Clostridia	J	50S ribosomal protein L31	rpmE	-	-	ko:K02909	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L31
HKD2_k127_5428381_1	1094508.Tsac_0324	7.086e-92	305.0	COG1435@1|root,COG1435@2|Bacteria,1TRVM@1239|Firmicutes,24CVH@186801|Clostridia,42GF5@68295|Thermoanaerobacterales	186801|Clostridia	F	thymidine kinase	tdk	-	2.7.1.21	ko:K00857	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01567,R02099,R08233	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	TK
HKD2_k127_5428381_2	1128398.Curi_c21530	6.264e-91	316.0	COG4124@1|root,COG4124@2|Bacteria,1U8S3@1239|Firmicutes,24C93@186801|Clostridia	186801|Clostridia	G	Glycosyl hydrolase family 26	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_26
HKD2_k127_5428424_4	330214.NIDE4049	2.577e-08	61.0	2BXN6@1|root,2ZK04@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5428424_1	1408422.JHYF01000009_gene1956	3.488e-38	148.0	COG1247@1|root,COG1247@2|Bacteria,1VYW2@1239|Firmicutes,2545A@186801|Clostridia,36SJ1@31979|Clostridiaceae	186801|Clostridia	M	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HKD2_k127_5428424_2	1321778.HMPREF1982_01411	4.307e-30	124.0	2CH44@1|root,33JG7@2|Bacteria,1VNIC@1239|Firmicutes,25DE5@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5428424_0	1121324.CLIT_23c04670	4.459e-183	585.0	COG1306@1|root,COG1306@2|Bacteria,1TQZV@1239|Firmicutes,24ADG@186801|Clostridia,25TB7@186804|Peptostreptococcaceae	186801|Clostridia	S	Putative glycosyl hydrolase domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4015
HKD2_k127_5428424_3	574087.Acear_0874	8.779e-17	79.0	COG0369@1|root,COG1151@2|Bacteria,1TP8X@1239|Firmicutes,247IN@186801|Clostridia	186801|Clostridia	C	Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O	hcp	-	1.7.99.1	ko:K05601	ko00910,map00910	-	R00143	RC02797	ko00000,ko00001,ko01000	-	-	-	Prismane
HKD2_k127_5428644_2	935948.KE386495_gene2123	1.478e-12	69.0	COG3906@1|root,COG3906@2|Bacteria,1VF5Z@1239|Firmicutes,24RAZ@186801|Clostridia,42H3M@68295|Thermoanaerobacterales	186801|Clostridia	S	Belongs to the UPF0473 family	-	-	-	-	-	-	-	-	-	-	-	-	DUF1292
HKD2_k127_5428644_1	941824.TCEL_00297	1.113e-19	90.0	COG1918@1|root,COG1918@2|Bacteria,1VEQU@1239|Firmicutes,24R31@186801|Clostridia,36PET@31979|Clostridiaceae	186801|Clostridia	P	FeoA	-	-	-	ko:K04758	-	-	-	-	ko00000,ko02000	-	-	-	FeoA
HKD2_k127_5428644_0	1031288.AXAA01000007_gene915	1.1e-234	739.0	COG0370@1|root,COG0370@2|Bacteria,1TP7E@1239|Firmicutes,24885@186801|Clostridia,36DF0@31979|Clostridiaceae	186801|Clostridia	P	transporter of a GTP-driven Fe(2 ) uptake system	feoB	-	-	ko:K04759	-	-	-	-	ko00000,ko02000	9.A.8.1	-	-	FeoB_C,FeoB_N,Gate
HKD2_k127_543103_0	536227.CcarbDRAFT_1912	1.85e-174	550.0	COG0426@1|root,COG0426@2|Bacteria,1TQE9@1239|Firmicutes,249CU@186801|Clostridia,36E70@31979|Clostridiaceae	186801|Clostridia	C	flavodoxin nitric oxide synthase	norV	-	1.6.3.4	ko:K22405	-	-	-	-	ko00000,ko01000	-	-	-	Flavodoxin_1,Lactamase_B
HKD2_k127_543103_1	1321778.HMPREF1982_02995	5.455e-84	285.0	COG0664@1|root,COG0664@2|Bacteria,1V5MZ@1239|Firmicutes,24AQS@186801|Clostridia,26AIC@186813|unclassified Clostridiales	186801|Clostridia	K	helix_turn_helix, cAMP Regulatory protein	-	-	-	ko:K21562	-	-	-	-	ko00000,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
HKD2_k127_543103_2	373903.Hore_06410	2.504e-06	56.0	COG1388@1|root,COG3773@1|root,COG1388@2|Bacteria,COG3773@2|Bacteria,1TRFW@1239|Firmicutes,25B9P@186801|Clostridia,3WBG9@53433|Halanaerobiales	186801|Clostridia	M	Cell Wall Hydrolase	-	-	3.5.1.28	ko:K01449	-	-	R04112	RC00064,RC00141	ko00000,ko01000	-	-	-	Hydrolase_2,LysM
HKD2_k127_5440964_18	1031288.AXAA01000013_gene529	5.617e-08	56.0	2EB32@1|root,3353U@2|Bacteria,1VJ87@1239|Firmicutes	1239|Firmicutes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5440964_21	1329516.JPST01000003_gene1177	5.936e-05	47.0	29SQ3@1|root,30DVY@2|Bacteria,1UBTF@1239|Firmicutes,4IN8Q@91061|Bacilli,27CGS@186824|Thermoactinomycetaceae	91061|Bacilli	S	Small acid-soluble spore protein H family	-	-	-	-	-	-	-	-	-	-	-	-	SspH
HKD2_k127_5440964_5	658088.HMPREF0987_01714	1.562e-155	500.0	COG0116@1|root,COG0116@2|Bacteria,1TP0X@1239|Firmicutes,248MA@186801|Clostridia,27IFJ@186928|unclassified Lachnospiraceae	186801|Clostridia	L	THUMP	ypsC	-	-	ko:K07444	-	-	-	-	ko00000,ko01000	-	-	-	THUMP,UPF0020
HKD2_k127_5440964_19	1168289.AJKI01000002_gene2352	1.205e-06	60.0	COG4915@1|root,COG4915@2|Bacteria	2|Bacteria	S	5-bromo-4-chloroindolyl phosphate hydrolysis protein	xpaC	-	-	-	-	-	-	-	-	-	-	-	Halogen_Hydrol
HKD2_k127_5440964_12	1131462.DCF50_p258	1.91e-45	172.0	COG5401@1|root,COG5401@2|Bacteria,1TQX6@1239|Firmicutes,249MF@186801|Clostridia,262UB@186807|Peptococcaceae	186801|Clostridia	S	PFAM Sporulation and spore germination	-	-	-	-	-	-	-	-	-	-	-	-	Germane
HKD2_k127_5440964_3	1511.CLOST_1621	6.121e-166	525.0	COG0451@1|root,COG0451@2|Bacteria,1TSUN@1239|Firmicutes,2485S@186801|Clostridia,25S57@186804|Peptostreptococcaceae	186801|Clostridia	GM	RmlD substrate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
HKD2_k127_5440964_1	340099.Teth39_0287	3.717e-195	614.0	COG0156@1|root,COG0156@2|Bacteria,1TPUX@1239|Firmicutes,2491D@186801|Clostridia,42FUG@68295|Thermoanaerobacterales	186801|Clostridia	H	PFAM Aminotransferase class I and II	kbl	GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008710,GO:0008890,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016407,GO:0016408,GO:0016453,GO:0016740,GO:0016746,GO:0016747,GO:0017144,GO:0018130,GO:0019752,GO:0019842,GO:0030170,GO:0032787,GO:0034641,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0070279,GO:0071704,GO:0072330,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.3.1.29,2.3.1.47	ko:K00639,ko:K00652	ko00260,ko00780,ko01100,map00260,map00780,map01100	M00123,M00573,M00577	R00371,R03210,R10124	RC00004,RC00039,RC00394,RC02725	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
HKD2_k127_5440964_0	1410653.JHVC01000006_gene109	6.124e-244	776.0	COG1199@1|root,COG1199@2|Bacteria,1TPNB@1239|Firmicutes,248ZI@186801|Clostridia,36E0Y@31979|Clostridiaceae	186801|Clostridia	L	helicase	dinG	-	3.1.12.1,3.6.4.12	ko:K07464,ko:K10844	ko03022,ko03420,map03022,map03420	M00290	-	-	ko00000,ko00001,ko00002,ko01000,ko02048,ko03021,ko03400	-	-	-	DEAD,DEAD_2,HBB,Helicase_C_2,PDDEXK_1
HKD2_k127_5440964_13	293826.Amet_0769	2.831e-44	172.0	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_9
HKD2_k127_5440964_16	1391647.AVSV01000003_gene1672	1.014e-32	139.0	COG1670@1|root,COG1670@2|Bacteria,1V1G8@1239|Firmicutes,24G73@186801|Clostridia,36I5H@31979|Clostridiaceae	186801|Clostridia	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
HKD2_k127_5440964_2	394503.Ccel_1886	1.691e-180	586.0	COG0849@1|root,COG0849@2|Bacteria,1TP1Z@1239|Firmicutes,249Y7@186801|Clostridia,36DWK@31979|Clostridiaceae	186801|Clostridia	D	cell division protein FtsA	ftsA	-	-	-	-	-	-	-	-	-	-	-	FtsA,MreB_Mbl
HKD2_k127_5440964_8	273068.TTE1768	8.224e-93	321.0	COG2720@1|root,COG2720@2|Bacteria,1TSH8@1239|Firmicutes,2493X@186801|Clostridia,42EY6@68295|Thermoanaerobacterales	186801|Clostridia	V	PFAM VanW family protein	-	-	-	ko:K18346	ko01502,ko02020,map01502,map02020	M00651	-	-	ko00000,ko00001,ko00002,ko01504	-	-	-	G5,PG_binding_4,VanW
HKD2_k127_5440964_11	1121289.JHVL01000018_gene594	3.021e-58	209.0	COG1655@1|root,COG1655@2|Bacteria,1UY0V@1239|Firmicutes,247VR@186801|Clostridia,36DI3@31979|Clostridiaceae	186801|Clostridia	S	Uncharacterized protein conserved in bacteria (DUF2225)	-	-	-	ko:K09766	-	-	-	-	ko00000	-	-	-	DUF2225,cNMP_binding
HKD2_k127_5440964_7	273068.TTE2215	3.91e-117	385.0	COG0714@1|root,COG0714@2|Bacteria,1TPKR@1239|Firmicutes,248IM@186801|Clostridia,42FCK@68295|Thermoanaerobacterales	186801|Clostridia	S	PFAM ATPase associated with various cellular activities	moxR	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
HKD2_k127_5440964_15	941824.TCEL_01504	1.346e-38	159.0	COG1721@1|root,COG1721@2|Bacteria,1VA48@1239|Firmicutes,24E5S@186801|Clostridia,36JTY@31979|Clostridiaceae	186801|Clostridia	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
HKD2_k127_5440964_10	580327.Tthe_0482	5.561e-64	245.0	COG1305@1|root,COG1305@2|Bacteria,1TP8K@1239|Firmicutes,24CZV@186801|Clostridia,42F4G@68295|Thermoanaerobacterales	186801|Clostridia	E	PFAM Transglutaminase-like	-	-	-	-	-	-	-	-	-	-	-	-	DUF4129,Transglut_core
HKD2_k127_5440964_6	1294142.CINTURNW_2032	7.413e-136	449.0	COG5002@1|root,COG5002@2|Bacteria,1VRP7@1239|Firmicutes,24YHW@186801|Clostridia,36UJK@31979|Clostridiaceae	186801|Clostridia	T	Histidine kinase	-	-	2.7.13.3	ko:K11527	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS,PAS_4,PAS_8,PAS_9
HKD2_k127_5440964_9	1487921.DP68_00835	3.2e-70	246.0	COG0561@1|root,COG0561@2|Bacteria,1U3W2@1239|Firmicutes,2486H@186801|Clostridia,36DQB@31979|Clostridiaceae	186801|Clostridia	S	hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_3
HKD2_k127_5440964_14	293826.Amet_3039	3.614e-44	173.0	COG3568@1|root,COG3568@2|Bacteria,1V9H0@1239|Firmicutes,24KPC@186801|Clostridia	186801|Clostridia	S	PFAM Endonuclease Exonuclease phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
HKD2_k127_5440964_17	485916.Dtox_0238	2.473e-32	127.0	COG1533@1|root,COG1533@2|Bacteria,1TPA3@1239|Firmicutes,249NM@186801|Clostridia,2604J@186807|Peptococcaceae	186801|Clostridia	L	TIGRFAM spore photoproduct lyase	splB	GO:0003674,GO:0003824,GO:0003913,GO:0005488,GO:0016829,GO:0016830,GO:0043167,GO:0043169,GO:0046872,GO:0048037,GO:0051536,GO:0051540,GO:0070283,GO:0140097	4.1.99.14	ko:K03716	-	-	-	-	ko00000,ko01000	-	-	-	Radical_SAM
HKD2_k127_5440964_4	1009370.ALO_00985	4.081e-163	521.0	COG1145@1|root,COG2006@1|root,COG1145@2|Bacteria,COG2006@2|Bacteria,1TRX2@1239|Firmicutes,4H3TS@909932|Negativicutes	909932|Negativicutes	C	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362,Fer4,Fer4_6
HKD2_k127_5443375_6	350688.Clos_0390	3.964e-40	153.0	COG1053@1|root,COG1053@2|Bacteria,1TPAR@1239|Firmicutes,247SY@186801|Clostridia,36UQE@31979|Clostridiaceae	186801|Clostridia	C	FAD dependent oxidoreductase	-	-	1.3.5.1,1.3.5.4,1.3.99.33	ko:K00239,ko:K00244,ko:K17363	ko00020,ko00190,ko00340,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,ko05134,map00020,map00190,map00340,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020,map05134	M00009,M00011,M00149,M00150,M00173,M00374,M00376	R02164,R10330	RC00045,RC00669	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,FMN_bind
HKD2_k127_5443375_0	1408422.JHYF01000007_gene1305	1.09e-215	684.0	COG4191@1|root,COG4191@2|Bacteria,1UYQH@1239|Firmicutes,249I4@186801|Clostridia,36GPP@31979|Clostridiaceae	186801|Clostridia	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg,dCache_1,sCache_2
HKD2_k127_5443375_3	350688.Clos_0388	2.884e-111	363.0	COG0745@1|root,COG0745@2|Bacteria,1V0JV@1239|Firmicutes,24DBU@186801|Clostridia,36IXU@31979|Clostridiaceae	186801|Clostridia	T	PFAM response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
HKD2_k127_5443375_5	1131730.BAVI_06674	4.869e-47	175.0	COG1670@1|root,COG1670@2|Bacteria,1UWQZ@1239|Firmicutes,4I3IY@91061|Bacilli,1ZEDU@1386|Bacillus	91061|Bacilli	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
HKD2_k127_5443375_7	697284.ERIC2_c01100	1.775e-07	60.0	COG1344@1|root,COG1344@2|Bacteria,1TP1K@1239|Firmicutes,4H9UA@91061|Bacilli,26SEI@186822|Paenibacillaceae	91061|Bacilli	N	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella	flaA	GO:0005575,GO:0005576,GO:0005623,GO:0009288,GO:0042995,GO:0043226,GO:0043228,GO:0044464	-	ko:K02406	ko02020,ko02040,ko04621,ko04626,ko05132,ko05134,map02020,map02040,map04621,map04626,map05132,map05134	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flagellin_C,Flagellin_N
HKD2_k127_5443375_4	1121334.KB911067_gene222	7.777e-59	207.0	COG2033@1|root,COG2033@2|Bacteria,1VA34@1239|Firmicutes,24J9I@186801|Clostridia	186801|Clostridia	C	Desulfoferrodoxin ferrous iron-binding	dfx	GO:0000302,GO:0000303,GO:0000305,GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0006091,GO:0006801,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009055,GO:0009636,GO:0009987,GO:0010035,GO:0016491,GO:0016721,GO:0019430,GO:0022900,GO:0033554,GO:0034599,GO:0034614,GO:0042221,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0071450,GO:0071451,GO:0072593,GO:0097237,GO:0098754,GO:0098869,GO:1901700,GO:1901701,GO:1990748	1.15.1.2	ko:K05919	-	-	-	-	ko00000,ko01000	-	-	-	Desulfoferrod_N,Desulfoferrodox
HKD2_k127_5443375_2	350688.Clos_0340	2.594e-121	397.0	COG2334@1|root,COG2334@2|Bacteria,1V87N@1239|Firmicutes,25DKK@186801|Clostridia	186801|Clostridia	S	Phosphotransferase enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	APH
HKD2_k127_5443375_1	536232.CLM_2022	2.795e-124	406.0	COG3568@1|root,COG3568@2|Bacteria,1U5BI@1239|Firmicutes,24A34@186801|Clostridia,36GWT@31979|Clostridiaceae	186801|Clostridia	S	Endonuclease exonuclease phosphatase family protein	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
HKD2_k127_5445066_5	1304880.JAGB01000001_gene475	4.527e-06	53.0	COG2843@1|root,COG2843@2|Bacteria,1UZW4@1239|Firmicutes,24950@186801|Clostridia	186801|Clostridia	M	Capsule synthesis protein	-	-	-	ko:K07282	-	-	-	-	ko00000	-	-	-	PGA_cap
HKD2_k127_5445066_2	1321778.HMPREF1982_04130	1.011e-138	445.0	COG0761@1|root,COG0761@2|Bacteria,1UHT7@1239|Firmicutes,25E67@186801|Clostridia	186801|Clostridia	IM	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis	ispH	-	1.17.7.4	ko:K02945,ko:K03527	ko00900,ko01100,ko01110,ko01130,ko03010,map00900,map01100,map01110,map01130,map03010	M00096,M00178	R05884,R08210	RC01137,RC01487	br01610,ko00000,ko00001,ko00002,ko01000,ko03011	-	-	-	LYTB
HKD2_k127_5445066_4	1443125.Z962_01905	1.998e-57	205.0	COG0212@1|root,COG0212@2|Bacteria,1VA91@1239|Firmicutes,24N7H@186801|Clostridia,36JPF@31979|Clostridiaceae	186801|Clostridia	H	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family	fthC	-	6.3.3.2	ko:K01934	ko00670,ko01100,map00670,map01100	-	R02301	RC00183	ko00000,ko00001,ko01000	-	-	-	5-FTHF_cyc-lig
HKD2_k127_5445066_1	1499689.CCNN01000007_gene1538	9.698e-192	605.0	COG0282@1|root,COG0282@2|Bacteria,1TQ22@1239|Firmicutes,248ZM@186801|Clostridia,36EE0@31979|Clostridiaceae	186801|Clostridia	F	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction	ackA	GO:0006082,GO:0006083,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016053,GO:0016999,GO:0017000,GO:0017144,GO:0019413,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:0072330,GO:1901576	2.7.2.1	ko:K00925	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00315,R01353	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetate_kinase
HKD2_k127_5445066_0	1487921.DP68_18060	9.564e-213	670.0	COG0168@1|root,COG0168@2|Bacteria,1TPAF@1239|Firmicutes,248K4@186801|Clostridia,36E52@31979|Clostridiaceae	186801|Clostridia	P	potassium uptake protein TrkH	trkH	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
HKD2_k127_5445066_3	1121335.Clst_0233	2.376e-67	236.0	COG0569@1|root,COG0569@2|Bacteria,1TPNS@1239|Firmicutes,24830@186801|Clostridia,3WGP4@541000|Ruminococcaceae	186801|Clostridia	P	K transport systems, NAD-binding component	trkA	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
HKD2_k127_5456777_2	1230342.CTM_01684	2.28e-78	270.0	COG0791@1|root,COG0791@2|Bacteria,1UZC6@1239|Firmicutes,247PE@186801|Clostridia,36E6P@31979|Clostridiaceae	186801|Clostridia	M	D-alanyl-D-alanine carboxypeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M15_4
HKD2_k127_5456777_0	913865.DOT_2662	1.004e-173	559.0	COG5002@1|root,COG5002@2|Bacteria,1TQ1H@1239|Firmicutes,247VG@186801|Clostridia,261B1@186807|Peptococcaceae	186801|Clostridia	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
HKD2_k127_5456777_1	913865.DOT_2661	3.221e-101	333.0	COG0745@1|root,COG0745@2|Bacteria,1TPZ0@1239|Firmicutes,2484X@186801|Clostridia,261D7@186807|Peptococcaceae	186801|Clostridia	K	PFAM response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
HKD2_k127_5466790_4	941824.TCEL_01765	4.669e-67	231.0	COG0699@1|root,COG0699@2|Bacteria,1TPPG@1239|Firmicutes,24829@186801|Clostridia,36DMZ@31979|Clostridiaceae	186801|Clostridia	S	ATPase. Has a role at an early stage in the morphogenesis of the spore coat	spoIVA	GO:0000003,GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0008144,GO:0008150,GO:0009653,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019954,GO:0030154,GO:0030312,GO:0030435,GO:0030436,GO:0030554,GO:0031160,GO:0032502,GO:0032553,GO:0032555,GO:0032559,GO:0034301,GO:0035639,GO:0036094,GO:0042601,GO:0042763,GO:0043167,GO:0043168,GO:0043934,GO:0043936,GO:0044464,GO:0048646,GO:0048856,GO:0048869,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K06398	-	-	-	-	ko00000	-	-	-	Spore_IV_A
HKD2_k127_5466790_3	1408422.JHYF01000015_gene464	3.329e-147	469.0	COG1586@1|root,COG1586@2|Bacteria,1TQ7S@1239|Firmicutes,2480M@186801|Clostridia,36ET4@31979|Clostridiaceae	186801|Clostridia	E	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine	speD	-	4.1.1.50	ko:K01611	ko00270,ko00330,ko01100,map00270,map00330,map01100	M00034,M00133	R00178	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	AdoMet_dc
HKD2_k127_5466790_0	941824.TCEL_00606	1.627e-178	565.0	COG2309@1|root,COG2309@2|Bacteria,1TP65@1239|Firmicutes,24AR8@186801|Clostridia,36E9B@31979|Clostridiaceae	186801|Clostridia	E	aminopeptidase	-	-	-	ko:K19689	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M29
HKD2_k127_5466790_1	857293.CAAU_2704	3.522e-170	541.0	COG2309@1|root,COG2309@2|Bacteria,1TP65@1239|Firmicutes,24AR8@186801|Clostridia,36E9B@31979|Clostridiaceae	186801|Clostridia	E	aminopeptidase	-	-	-	ko:K19689	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M29
HKD2_k127_5466790_5	857293.CAAU_0415	3.266e-64	228.0	arCOG08608@1|root,32CXY@2|Bacteria,1V6CC@1239|Firmicutes,24AQP@186801|Clostridia,36EBJ@31979|Clostridiaceae	186801|Clostridia	S	phospholipase C	-	-	3.1.4.3	ko:K01114	ko00562,ko00564,ko00565,ko01100,ko01110,ko02024,ko04919,map00562,map00564,map00565,map01100,map01110,map02024,map04919	-	R01312,R02027,R02052,R03332,R07381	RC00017,RC00425	ko00000,ko00001,ko01000,ko02042	-	-	-	Zn_dep_PLPC
HKD2_k127_5466790_6	1321778.HMPREF1982_02261	4.326e-47	173.0	COG1633@1|root,COG1633@2|Bacteria,1V860@1239|Firmicutes,24ERW@186801|Clostridia	186801|Clostridia	G	PFAM Rubrerythrin	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
HKD2_k127_5466790_2	1347392.CCEZ01000074_gene1919	1.242e-152	501.0	COG1032@1|root,COG1032@2|Bacteria,1TPGT@1239|Firmicutes,247JS@186801|Clostridia,36DF6@31979|Clostridiaceae	186801|Clostridia	C	Radical SAM	-	-	1.21.98.3	ko:K04034	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R06268,R06269,R06270	RC00741,RC01491,RC01492	ko00000,ko00001,ko01000	-	-	-	B12-binding,DUF4080,Radical_SAM
HKD2_k127_5468421_1	1304284.L21TH_2562	1.161e-75	258.0	COG1014@1|root,COG1014@2|Bacteria,1V1DT@1239|Firmicutes,24HIC@186801|Clostridia,36EAN@31979|Clostridiaceae	186801|Clostridia	C	PFAM pyruvate ferredoxin flavodoxin oxidoreductase	iorB	-	1.2.7.8	ko:K00180	-	-	-	-	br01601,ko00000,ko01000	-	-	-	POR
HKD2_k127_5468421_0	1268072.PSAB_09460	2.332e-154	510.0	COG0840@1|root,COG0840@2|Bacteria,1TP5A@1239|Firmicutes,4HGPZ@91061|Bacilli,26V9X@186822|Paenibacillaceae	91061|Bacilli	NT	chemotaxis protein	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	MCPsignal,dCache_1
HKD2_k127_5474028_1	871963.Desdi_3152	2.164e-56	199.0	COG2247@1|root,COG3420@1|root,COG2247@2|Bacteria,COG3420@2|Bacteria,1UWYH@1239|Firmicutes,24FEY@186801|Clostridia,260Q9@186807|Peptococcaceae	186801|Clostridia	M	Putative cell wall binding repeat 2	-	-	-	-	-	-	-	-	-	-	-	-	CW_binding_2
HKD2_k127_5474028_0	1304284.L21TH_1551	1.319e-171	546.0	COG1228@1|root,COG1228@2|Bacteria,1TPNQ@1239|Firmicutes,248UT@186801|Clostridia,36E56@31979|Clostridiaceae	186801|Clostridia	Q	amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1,Amidohydro_3
HKD2_k127_5474028_4	1304880.JAGB01000003_gene1137	7.094e-52	189.0	COG3601@1|root,COG3601@2|Bacteria,1V4BW@1239|Firmicutes,24E4V@186801|Clostridia	186801|Clostridia	S	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins	ribU	-	-	-	-	-	-	-	-	-	-	-	ECF_trnsprt
HKD2_k127_5474028_2	1304284.L21TH_1555	1.574e-54	195.0	COG0802@1|root,COG0802@2|Bacteria,1V6CV@1239|Firmicutes,24MSS@186801|Clostridia,36IUF@31979|Clostridiaceae	186801|Clostridia	S	Threonylcarbamoyl adenosine biosynthesis protein TsaE	ydiB	-	-	ko:K06925	-	-	-	-	ko00000,ko03016	-	-	-	TsaE
HKD2_k127_5474028_3	1121289.JHVL01000009_gene1456	1.646e-54	205.0	COG1214@1|root,COG1214@2|Bacteria,1V4YX@1239|Firmicutes,24A0P@186801|Clostridia,36EHE@31979|Clostridiaceae	186801|Clostridia	O	Glycoprotease	yeaZ	-	-	ko:K14742	-	-	-	-	ko00000,ko03016	-	-	-	Acetyltransf_1,Peptidase_M22
HKD2_k127_5474028_6	649747.HMPREF0083_00176	8.658e-42	168.0	COG0454@1|root,COG0456@2|Bacteria,1V6KU@1239|Firmicutes,4HIKU@91061|Bacilli,26RAQ@186822|Paenibacillaceae	91061|Bacilli	K	Acetyltransferase	rimI	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1
HKD2_k127_5474028_5	398512.JQKC01000005_gene5359	1.904e-47	175.0	COG1595@1|root,COG1595@2|Bacteria,1TS3M@1239|Firmicutes,24GQ2@186801|Clostridia,3WINH@541000|Ruminococcaceae	186801|Clostridia	K	TIGRFAM RNA polymerase sigma factor, sigma-70 family	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD2_k127_5487709_0	1195236.CTER_0329	1.908e-186	598.0	COG2608@1|root,COG2836@1|root,COG4633@1|root,COG2608@2|Bacteria,COG2836@2|Bacteria,COG4633@2|Bacteria,1TQ02@1239|Firmicutes,249HC@186801|Clostridia,3WNAJ@541000|Ruminococcaceae	186801|Clostridia	P	Cytochrome C biogenesis protein transmembrane region	-	-	-	-	-	-	-	-	-	-	-	-	Cupredoxin_1,DsbD_2,HMA
HKD2_k127_5487709_1	1122212.AULO01000009_gene934	2.321e-64	232.0	COG2199@1|root,COG3706@2|Bacteria,1MXAW@1224|Proteobacteria,1RZ41@1236|Gammaproteobacteria,1XIYN@135619|Oceanospirillales	135619|Oceanospirillales	T	Diguanylate cyclase	-	-	2.7.7.65	ko:K13590	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000	-	-	-	GGDEF
HKD2_k127_5511700_0	1487921.DP68_01870	2.175e-169	532.0	COG1063@1|root,COG1063@2|Bacteria,1TPIW@1239|Firmicutes,24AY7@186801|Clostridia,36VQ2@31979|Clostridiaceae	186801|Clostridia	E	Dehydrogenase	adhB	-	1.1.1.1,1.1.1.284,1.2.1.46	ko:K00121,ko:K00148	ko00010,ko00071,ko00350,ko00625,ko00626,ko00680,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,ko05204,map00010,map00071,map00350,map00625,map00626,map00680,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01200,map01220,map05204	-	R00604,R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R06983,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00188,RC00649,RC01715,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_N_assoc,ADH_zinc_N
HKD2_k127_5511700_1	1211814.CAPG01000065_gene3150	6.119e-96	318.0	COG2865@1|root,COG2865@2|Bacteria,1UP51@1239|Firmicutes,4IV0N@91061|Bacilli,1ZSIG@1386|Bacillus	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5511700_2	1321778.HMPREF1982_04627	2.108e-72	253.0	COG0840@1|root,COG0840@2|Bacteria,1TP5A@1239|Firmicutes,247S3@186801|Clostridia,26B24@186813|unclassified Clostridiales	186801|Clostridia	NT	Psort location CytoplasmicMembrane, score	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	4HB_MCP_1,MCPsignal
HKD2_k127_5518029_6	1408422.JHYF01000006_gene1294	7.721e-110	359.0	COG1521@1|root,COG1521@2|Bacteria,1TR0X@1239|Firmicutes,248PX@186801|Clostridia,36E0D@31979|Clostridiaceae	186801|Clostridia	F	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis	coaX	-	2.7.1.33	ko:K03525	ko00770,ko01100,map00770,map01100	M00120	R02971,R03018,R04391	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Pan_kinase
HKD2_k127_5518029_5	1304284.L21TH_0792	1.042e-113	375.0	COG0340@1|root,COG1654@1|root,COG0340@2|Bacteria,COG1654@2|Bacteria,1TQCU@1239|Firmicutes,248CK@186801|Clostridia,36F7S@31979|Clostridiaceae	186801|Clostridia	HK	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor	birA	-	6.3.4.15	ko:K03524	ko00780,ko01100,map00780,map01100	-	R01074,R05145	RC00043,RC00070,RC00096,RC02896	ko00000,ko00001,ko01000,ko03000	-	-	-	BPL_C,BPL_LplA_LipB,HTH_11
HKD2_k127_5518029_3	1304880.JAGB01000001_gene134	6.314e-163	521.0	COG1883@1|root,COG1883@2|Bacteria,1TPEP@1239|Firmicutes,248ET@186801|Clostridia	186801|Clostridia	C	decarboxylase beta subunit	gcdB	-	4.1.1.3	ko:K01572	ko00620,ko01100,map00620,map01100	-	R00217	RC00040	ko00000,ko00001,ko01000,ko02000	3.B.1.1.1	-	-	OAD_beta
HKD2_k127_5518029_10	509191.AEDB02000003_gene1108	3.331e-32	131.0	COG4770@1|root,COG4770@2|Bacteria,1VA1E@1239|Firmicutes,24MUJ@186801|Clostridia,3WK2X@541000|Ruminococcaceae	186801|Clostridia	I	Biotin-requiring enzyme	gcdC	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl
HKD2_k127_5518029_11	1511.CLOST_0943	5.624e-09	61.0	COG3630@1|root,COG3630@2|Bacteria,1VKW0@1239|Firmicutes,24VA0@186801|Clostridia	186801|Clostridia	C	decarboxylase, gamma subunit	-	-	-	-	-	-	-	-	-	-	-	-	OAD_gamma
HKD2_k127_5518029_1	1408422.JHYF01000006_gene1278	3.649e-265	823.0	COG4799@1|root,COG4799@2|Bacteria,1TQCV@1239|Firmicutes,247WG@186801|Clostridia,36E1X@31979|Clostridiaceae	186801|Clostridia	I	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)	yqjD	-	2.1.3.15,6.4.1.3	ko:K01966	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R01859	RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
HKD2_k127_5518029_8	1304284.L21TH_0797	2.755e-62	216.0	COG0346@1|root,COG0346@2|Bacteria,1V6SC@1239|Firmicutes,24HPI@186801|Clostridia,36J72@31979|Clostridiaceae	186801|Clostridia	E	Glyoxalase-like domain	mce	-	4.4.1.5,5.1.99.1	ko:K01759,ko:K05606	ko00280,ko00620,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00620,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00375,M00376,M00741	R02530,R02765,R09979	RC00004,RC00740,RC00780,RC02739	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyoxalase_4
HKD2_k127_5518029_4	293826.Amet_4540	4.124e-114	376.0	COG1703@1|root,COG1703@2|Bacteria,1TQT4@1239|Firmicutes,24944@186801|Clostridia,36G13@31979|Clostridiaceae	186801|Clostridia	E	ArgK protein	argK	-	-	ko:K07588	-	-	-	-	ko00000,ko01000	-	-	-	ArgK
HKD2_k127_5518029_7	1304284.L21TH_0799	2.722e-63	219.0	COG2185@1|root,COG2185@2|Bacteria,1V3QN@1239|Firmicutes,24HAR@186801|Clostridia,36J94@31979|Clostridiaceae	186801|Clostridia	I	B12 binding domain	-	-	5.4.99.2	ko:K01849	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding
HKD2_k127_5518029_0	1408422.JHYF01000006_gene1274	2.917e-284	881.0	COG1884@1|root,COG1884@2|Bacteria,1TQAD@1239|Firmicutes,24BDK@186801|Clostridia,36H9W@31979|Clostridiaceae	186801|Clostridia	I	Methylmalonyl-CoA mutase	-	-	5.4.99.2	ko:K01847,ko:K01848	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	MM_CoA_mutase
HKD2_k127_5518029_9	293826.Amet_0908	2.754e-46	170.0	COG5496@1|root,COG5496@2|Bacteria,1VAZJ@1239|Firmicutes,24MWR@186801|Clostridia,36KPD@31979|Clostridiaceae	186801|Clostridia	S	THIoesterase	-	-	3.1.2.29	ko:K18700	-	-	-	-	ko00000,ko01000	-	-	-	4HBT
HKD2_k127_5518029_2	1304284.L21TH_0803	2.246e-257	806.0	COG0465@1|root,COG0465@2|Bacteria,1TPTV@1239|Firmicutes,247WQ@186801|Clostridia,36DIC@31979|Clostridiaceae	186801|Clostridia	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
HKD2_k127_5519577_2	857293.CAAU_0146	5.925e-231	720.0	COG2723@1|root,COG2723@2|Bacteria,1TP19@1239|Firmicutes,2485V@186801|Clostridia,36DZU@31979|Clostridiaceae	186801|Clostridia	G	Belongs to the glycosyl hydrolase 1 family	-	-	3.2.1.21	ko:K05350	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_1
HKD2_k127_5519577_4	857293.CAAU_0145	3.244e-229	715.0	COG2115@1|root,COG2115@2|Bacteria,1TQW2@1239|Firmicutes,24869@186801|Clostridia,36EXR@31979|Clostridiaceae	186801|Clostridia	G	Belongs to the xylose isomerase family	xylA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	5.3.1.5	ko:K01805	ko00040,ko00051,ko01100,map00040,map00051,map01100	-	R00878,R01432	RC00376,RC00516	ko00000,ko00001,ko01000	-	-	iHN637.CLJU_RS08960	AP_endonuc_2
HKD2_k127_5519577_3	1410670.JHXF01000003_gene1344	1.137e-230	723.0	COG1070@1|root,COG1070@2|Bacteria,1TQ1I@1239|Firmicutes,247NR@186801|Clostridia,3WGAY@541000|Ruminococcaceae	186801|Clostridia	G	Sugar (pentulose and hexulose) kinases	xylB	-	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
HKD2_k127_5519577_15	1321778.HMPREF1982_01898	9.601e-92	307.0	COG5482@1|root,COG5482@2|Bacteria,1V3FI@1239|Firmicutes,24IKI@186801|Clostridia	186801|Clostridia	S	Putative PD-(D/E)XK phosphodiesterase (DUF2161)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2161
HKD2_k127_5519577_1	1121335.Clst_1985	9.975e-237	741.0	COG0696@1|root,COG0696@2|Bacteria,1TPM4@1239|Firmicutes,247JG@186801|Clostridia,3WGBI@541000|Ruminococcaceae	186801|Clostridia	G	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate	gpmI	-	5.4.2.12	ko:K15633	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,Phosphodiest,iPGM_N
HKD2_k127_5519577_17	332101.JIBU02000073_gene3937	3.645e-84	286.0	COG0491@1|root,COG0491@2|Bacteria,1V0KE@1239|Firmicutes,24D1B@186801|Clostridia,36F5X@31979|Clostridiaceae	186801|Clostridia	S	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HKD2_k127_5519577_9	720554.Clocl_1088	3.519e-158	504.0	COG2502@1|root,COG2502@2|Bacteria,1TP28@1239|Firmicutes,248S4@186801|Clostridia,3WHV3@541000|Ruminococcaceae	186801|Clostridia	E	aspartate-ammonia ligase	asnA	-	6.3.1.1	ko:K01914	ko00250,ko00460,ko01100,ko01110,ko01230,map00250,map00460,map01100,map01110,map01230	-	R00483	RC00010	ko00000,ko00001,ko01000	-	-	-	AsnA
HKD2_k127_5519577_10	696281.Desru_0068	9.46e-153	488.0	COG1902@1|root,COG1902@2|Bacteria,1TPM6@1239|Firmicutes,247V1@186801|Clostridia,260GV@186807|Peptococcaceae	186801|Clostridia	C	PFAM NADH flavin oxidoreductase NADH oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_FMN
HKD2_k127_5519577_22	1294142.CINTURNW_4232	1.309e-40	154.0	COG3238@1|root,COG3238@2|Bacteria,1V7PX@1239|Firmicutes,24MM7@186801|Clostridia,36KFC@31979|Clostridiaceae	186801|Clostridia	S	Putative inner membrane exporter, YdcZ	-	-	-	ko:K09936	ko02024,map02024	-	-	-	ko00000,ko00001,ko02000	2.A.7.21	-	-	DMT_YdcZ
HKD2_k127_5519577_21	1294142.CINTURNW_4233	3.473e-48	176.0	COG3238@1|root,COG3238@2|Bacteria,1V6I0@1239|Firmicutes,24MVN@186801|Clostridia,36M40@31979|Clostridiaceae	186801|Clostridia	S	Putative inner membrane exporter, YdcZ	-	-	-	ko:K09936	ko02024,map02024	-	-	-	ko00000,ko00001,ko02000	2.A.7.21	-	-	DMT_YdcZ
HKD2_k127_5519577_16	1294142.CINTURNW_4234	6.611e-88	295.0	COG0664@1|root,COG0664@2|Bacteria,1V2AH@1239|Firmicutes,24H46@186801|Clostridia,36IIT@31979|Clostridiaceae	186801|Clostridia	K	cyclic nucleotide-binding	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Crp_2,cNMP_binding
HKD2_k127_5519577_5	864565.HMPREF0379_1303	7.39e-225	706.0	COG1328@1|root,COG1328@2|Bacteria,1TPAC@1239|Firmicutes,24A2W@186801|Clostridia	186801|Clostridia	F	glycine radical enzyme, YjjI family	yjjI	-	-	-	-	-	-	-	-	-	-	-	DUF3029
HKD2_k127_5519577_18	195103.CPF_0641	1.538e-77	269.0	COG1180@1|root,COG1180@2|Bacteria,1TPK2@1239|Firmicutes,24871@186801|Clostridia,36F0C@31979|Clostridiaceae	186801|Clostridia	O	radical SAM domain protein	yjjW	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4,Fer4_12,Fer4_6,Radical_SAM
HKD2_k127_5519577_14	1410653.JHVC01000016_gene382	2.174e-99	336.0	COG3835@1|root,COG3835@2|Bacteria,1TTCF@1239|Firmicutes,24CMJ@186801|Clostridia,36F2T@31979|Clostridiaceae	186801|Clostridia	KT	Putative sugar diacid recognition	-	-	-	ko:K02647	-	-	-	-	ko00000,ko03000	-	-	-	Diacid_rec,HTH_30
HKD2_k127_5519577_8	1262449.CP6013_1549	2.109e-164	525.0	COG1929@1|root,COG1929@2|Bacteria,1TPSI@1239|Firmicutes,249SH@186801|Clostridia,36E78@31979|Clostridiaceae	186801|Clostridia	G	Belongs to the glycerate kinase type-1 family	glxK	-	2.7.1.165	ko:K00865	ko00260,ko00561,ko00630,ko01100,ko01120,ko01130,map00260,map00561,map00630,map01100,map01120,map01130	-	R08572	RC00002,RC00428	ko00000,ko00001,ko01000	-	-	-	Gly_kinase
HKD2_k127_5519577_7	1410653.JHVC01000016_gene384	6.711e-195	617.0	COG2610@1|root,COG2610@2|Bacteria,1TQ14@1239|Firmicutes,248PQ@186801|Clostridia,36ESW@31979|Clostridiaceae	186801|Clostridia	EG	Gluconate	-	-	-	ko:K03299	-	-	-	-	ko00000,ko02000	2.A.8	-	-	GntP_permease
HKD2_k127_5519577_6	1540257.JQMW01000011_gene1811	1.035e-208	655.0	COG1362@1|root,COG1362@2|Bacteria,1TQ3Z@1239|Firmicutes,248UP@186801|Clostridia,36EV0@31979|Clostridiaceae	186801|Clostridia	E	M18 family aminopeptidase	apeB	-	3.4.11.21	ko:K01267	-	-	-	-	ko00000,ko01000,ko01002,ko04131	-	-	-	Peptidase_M18
HKD2_k127_5519577_13	435591.BDI_1734	9.183e-101	336.0	COG1052@1|root,COG1052@2|Bacteria,4NJGJ@976|Bacteroidetes,2FPFB@200643|Bacteroidia,22XF1@171551|Porphyromonadaceae	976|Bacteroidetes	CH	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	2-Hacid_dh,2-Hacid_dh_C
HKD2_k127_5519577_0	332101.JIBU02000023_gene4675	0.0	2169.0	COG1924@1|root,COG3580@1|root,COG3581@1|root,COG1924@2|Bacteria,COG3580@2|Bacteria,COG3581@2|Bacteria,1TPU5@1239|Firmicutes,2481F@186801|Clostridia,36DSJ@31979|Clostridiaceae	186801|Clostridia	I	CoA-substrate-specific enzyme activase	-	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG,DUF2229,HGD-D
HKD2_k127_5519577_20	536227.CcarbDRAFT_3210	4.788e-55	199.0	COG1309@1|root,COG1309@2|Bacteria,1VC4P@1239|Firmicutes,24NHV@186801|Clostridia,36P8J@31979|Clostridiaceae	186801|Clostridia	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
HKD2_k127_5519577_19	1121342.AUCO01000005_gene334	1.596e-70	241.0	COG1225@1|root,COG1225@2|Bacteria,1UV64@1239|Firmicutes,24HTS@186801|Clostridia,36IS2@31979|Clostridiaceae	186801|Clostridia	O	PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	-	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
HKD2_k127_5519577_12	203119.Cthe_0806	1.944e-101	357.0	COG5002@1|root,COG5002@2|Bacteria,1VRP7@1239|Firmicutes,24YHW@186801|Clostridia,3WGBY@541000|Ruminococcaceae	186801|Clostridia	T	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
HKD2_k127_5519577_11	1443125.Z962_11455	4.837e-149	481.0	COG0025@1|root,COG0025@2|Bacteria,1UJT4@1239|Firmicutes,25F9G@186801|Clostridia,36UXM@31979|Clostridiaceae	186801|Clostridia	P	Sodium/hydrogen exchanger family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
HKD2_k127_5556254_1	580327.Tthe_0656	2.439e-243	753.0	COG3534@1|root,COG3534@2|Bacteria,1TR7B@1239|Firmicutes,248ZA@186801|Clostridia,42HXK@68295|Thermoanaerobacterales	186801|Clostridia	G	SMART Alpha-L-arabinofuranosidase	-	-	3.2.1.55	ko:K01209	ko00520,map00520	-	R01762	-	ko00000,ko00001,ko01000	-	GH51	-	Alpha-L-AF_C
HKD2_k127_5556254_3	1291050.JAGE01000001_gene568	6.28e-152	485.0	COG0395@1|root,COG0395@2|Bacteria,1TPHS@1239|Firmicutes,24AJG@186801|Clostridia,3WJNM@541000|Ruminococcaceae	186801|Clostridia	U	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K17320	ko02010,map02010	M00603	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.29,3.A.1.1.9	-	-	BPD_transp_1
HKD2_k127_5556254_2	1195236.CTER_1790	2.297e-156	497.0	COG4209@1|root,COG4209@2|Bacteria,1TP33@1239|Firmicutes,247UA@186801|Clostridia	186801|Clostridia	P	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K17319	ko02010,map02010	M00603	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.29,3.A.1.1.9	-	-	BPD_transp_1
HKD2_k127_5556254_0	1195236.CTER_1791	1.888e-261	816.0	COG1653@1|root,COG1653@2|Bacteria,1TSF4@1239|Firmicutes,24DIH@186801|Clostridia,3WPEV@541000|Ruminococcaceae	186801|Clostridia	G	ABC-type sugar transport system periplasmic component	-	-	-	ko:K17318	ko02010,map02010	M00603	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.29,3.A.1.1.9	-	-	SBP_bac_1
HKD2_k127_5556254_4	1195236.CTER_1793	7.165e-130	420.0	COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1UYH7@1239|Firmicutes,249E3@186801|Clostridia	186801|Clostridia	T	response regulator	-	-	-	ko:K07720	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_18,Response_reg
HKD2_k127_5559023_2	1487921.DP68_10570	8.879e-50	179.0	2EDMK@1|root,337HE@2|Bacteria,1VJIK@1239|Firmicutes,24UB4@186801|Clostridia,36NU7@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4363
HKD2_k127_5559023_1	1487921.DP68_10565	1.82e-103	340.0	COG2323@1|root,COG2323@2|Bacteria,1V667@1239|Firmicutes,24GV0@186801|Clostridia,36IFY@31979|Clostridiaceae	186801|Clostridia	S	Protein of unknown function (DUF421)	-	-	-	-	-	-	-	-	-	-	-	-	DUF421
HKD2_k127_5559023_3	1151292.QEW_2924	2.274e-45	168.0	2F3YQ@1|root,33WQN@2|Bacteria,1VVFW@1239|Firmicutes,24NI0@186801|Clostridia,25TII@186804|Peptostreptococcaceae	186801|Clostridia	S	Protein of unknown function (DUF3785)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3785
HKD2_k127_5559023_0	1408422.JHYF01000016_gene101	0.0	1079.0	COG1032@1|root,COG1032@2|Bacteria,1TQ8X@1239|Firmicutes,248IW@186801|Clostridia,36DJY@31979|Clostridiaceae	186801|Clostridia	C	UPF0313 protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF3362,Radical_SAM,Radical_SAM_N
HKD2_k127_5559023_5	1120746.CCNL01000011_gene1884	1.39e-15	81.0	296ME@1|root,2ZTWQ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5559023_4	1280692.AUJL01000008_gene2395	2.25e-41	156.0	COG1915@1|root,COG1915@2|Bacteria,1TT91@1239|Firmicutes,24A6C@186801|Clostridia,36GXY@31979|Clostridiaceae	186801|Clostridia	S	PFAM LOR SDH bifunctional enzyme conserved region	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5586909_3	350688.Clos_2006	2.371e-29	123.0	COG2227@1|root,COG2227@2|Bacteria,1V218@1239|Firmicutes,25EUC@186801|Clostridia,36UUN@31979|Clostridiaceae	186801|Clostridia	H	Nodulation protein S (NodS)	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
HKD2_k127_5586909_4	1280692.AUJL01000007_gene1296	3.255e-15	77.0	2EIJI@1|root,33CAV@2|Bacteria,1VK5E@1239|Firmicutes,24MMQ@186801|Clostridia,36KUX@31979|Clostridiaceae	186801|Clostridia	S	Small, acid-soluble spore proteins, alpha/beta type	-	-	-	-	-	-	-	-	-	-	-	-	SASP
HKD2_k127_5586909_1	913865.DOT_1376	1.748e-106	354.0	COG1924@1|root,COG1924@2|Bacteria,1TPU5@1239|Firmicutes,2481F@186801|Clostridia,260B5@186807|Peptococcaceae	186801|Clostridia	I	BadF BadG BcrA BcrD	-	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG
HKD2_k127_5586909_0	1321778.HMPREF1982_04582	1.298e-168	536.0	COG3581@1|root,COG3581@2|Bacteria,1TPPP@1239|Firmicutes,249C8@186801|Clostridia,26ASX@186813|unclassified Clostridiales	186801|Clostridia	I	PFAM CoA enzyme activase uncharacterised domain (DUF2229)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2229
HKD2_k127_5586909_2	1196322.A370_04676	3.263e-66	229.0	COG3580@1|root,COG3580@2|Bacteria,1TR03@1239|Firmicutes,24987@186801|Clostridia,36DX9@31979|Clostridiaceae	186801|Clostridia	I	CoA enzyme activase uncharacterised domain (DUF2229)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2229
HKD2_k127_5591050_1	1128398.Curi_c28440	5.6e-58	214.0	COG3935@1|root,COG3935@2|Bacteria,1TPR5@1239|Firmicutes,248E7@186801|Clostridia,269KH@186813|unclassified Clostridiales	186801|Clostridia	L	Replication initiation and membrane attachment	dnaD	-	-	-	-	-	-	-	-	-	-	-	DnaB_2
HKD2_k127_5591050_0	580331.Thit_2316	1.701e-91	310.0	COG1484@1|root,COG1484@2|Bacteria,1TPKM@1239|Firmicutes,2483D@186801|Clostridia,42F78@68295|Thermoanaerobacterales	186801|Clostridia	L	SMART AAA ATPase	dnaC	-	-	ko:K02315	-	-	-	-	ko00000,ko03032	-	-	-	IstB_IS21
HKD2_k127_56293_0	697303.Thewi_2175	6.903e-263	821.0	COG0449@1|root,COG0449@2|Bacteria,1TPGU@1239|Firmicutes,248F8@186801|Clostridia,42EKN@68295|Thermoanaerobacterales	186801|Clostridia	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
HKD2_k127_56293_1	1304284.L21TH_0025	8.712e-127	411.0	COG1109@1|root,COG1109@2|Bacteria,1TP1X@1239|Firmicutes,2499P@186801|Clostridia,36DMU@31979|Clostridiaceae	186801|Clostridia	G	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate	glmM	-	5.4.2.10	ko:K03431	ko00520,ko01100,ko01130,map00520,map01100,map01130	-	R02060	RC00408	ko00000,ko00001,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
HKD2_k127_5633536_0	293826.Amet_1111	9.588e-173	553.0	COG0534@1|root,COG0534@2|Bacteria,1TPFM@1239|Firmicutes,247J9@186801|Clostridia,36DJD@31979|Clostridiaceae	186801|Clostridia	V	MATE efflux family protein	-	-	-	-	-	-	-	-	-	-	-	-	MatE
HKD2_k127_5633536_1	1121289.JHVL01000014_gene1802	4.839e-154	501.0	COG0697@1|root,COG0697@2|Bacteria,1TP7K@1239|Firmicutes,248Q8@186801|Clostridia,36DVY@31979|Clostridiaceae	186801|Clostridia	EG	Spore germination protein	-	-	-	ko:K06295	-	-	-	-	ko00000	-	-	-	GerA
HKD2_k127_5633536_3	398512.JQKC01000013_gene1428	1.378e-88	306.0	28M4H@1|root,2ZAIE@2|Bacteria,1TPXD@1239|Firmicutes,25EJK@186801|Clostridia,3WN8X@541000|Ruminococcaceae	186801|Clostridia	S	TIGRFAM germination protein, Ger(x)C family	gerAC	-	-	ko:K06297	-	-	-	-	ko00000	-	-	-	Spore_GerAC
HKD2_k127_5633536_5	768710.DesyoDRAFT_3492	9.549e-05	48.0	2E5EX@1|root,3306S@2|Bacteria,1VH1E@1239|Firmicutes	1239|Firmicutes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5633536_2	398512.JQKC01000013_gene1426	2.721e-105	354.0	COG0531@1|root,COG0531@2|Bacteria,1UF40@1239|Firmicutes,25EVI@186801|Clostridia,3WSMK@541000|Ruminococcaceae	186801|Clostridia	E	Spore germination protein	-	-	-	ko:K06296	-	-	-	-	ko00000,ko02000	2.A.3.9.3	-	-	Spore_permease
HKD2_k127_5633536_4	632335.Calkr_1622	1.312e-69	241.0	2DBB3@1|root,2Z85F@2|Bacteria,1UP54@1239|Firmicutes,248JK@186801|Clostridia	186801|Clostridia	S	Domain of unknown function (4846)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4846
HKD2_k127_5651780_3	558169.AGAV01000015_gene421	9.747e-78	270.0	28I0M@1|root,2Z85B@2|Bacteria,1TTBC@1239|Firmicutes,4HENN@91061|Bacilli	91061|Bacilli	S	Protein of unknown function (DUF3231)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3231
HKD2_k127_5651780_0	1511.CLOST_1906	1.631e-189	596.0	COG0012@1|root,COG0012@2|Bacteria,1TPRK@1239|Firmicutes,2482Z@186801|Clostridia,25QQJ@186804|Peptostreptococcaceae	186801|Clostridia	J	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner	ychF	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,YchF-GTPase_C
HKD2_k127_5651780_2	931276.Cspa_c47950	2.027e-135	436.0	COG2116@1|root,COG2116@2|Bacteria,1TRTT@1239|Firmicutes,24BU5@186801|Clostridia,36F4N@31979|Clostridiaceae	186801|Clostridia	P	Formate nitrite	fnt	-	-	ko:K21993	-	-	-	-	ko00000,ko02000	1.A.16.2	-	-	Form_Nir_trans
HKD2_k127_5651780_4	1078085.HMPREF1210_00641	7.913e-24	110.0	2DPBV@1|root,331FD@2|Bacteria,1VI9S@1239|Firmicutes,4HR6J@91061|Bacilli	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5651780_1	1195236.CTER_4343	1.344e-159	511.0	COG0442@1|root,COG0442@2|Bacteria,1TRBV@1239|Firmicutes,249PY@186801|Clostridia,3WI2G@541000|Ruminococcaceae	186801|Clostridia	J	Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily	proS	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA_edit
HKD2_k127_5664648_2	332101.JIBU02000006_gene456	6.123e-72	243.0	COG1388@1|root,COG3858@1|root,COG1388@2|Bacteria,COG3858@2|Bacteria,1TQK2@1239|Firmicutes,247YF@186801|Clostridia,36E8N@31979|Clostridiaceae	186801|Clostridia	M	family 18	-	-	-	ko:K06306	-	-	-	-	ko00000	-	-	-	Glyco_hydro_18,LysM
HKD2_k127_5664648_0	1487921.DP68_13000	8.949e-184	578.0	COG0306@1|root,COG0306@2|Bacteria,1TQ3D@1239|Firmicutes,247ZC@186801|Clostridia,36FB1@31979|Clostridiaceae	186801|Clostridia	P	phosphate transporter	pit	-	-	ko:K03306	-	-	-	-	ko00000	2.A.20	-	-	PHO4
HKD2_k127_5664648_1	1321778.HMPREF1982_03567	1.731e-104	342.0	COG1392@1|root,COG1392@2|Bacteria,1UYRI@1239|Firmicutes,24BCU@186801|Clostridia	186801|Clostridia	P	Phosphate transport regulator	-	-	-	ko:K07220	-	-	-	-	ko00000	-	-	-	PhoU_div
HKD2_k127_5671426_4	445335.CBN_3528	1.277e-91	304.0	COG0522@1|root,COG0522@2|Bacteria,1TR0J@1239|Firmicutes,248Y5@186801|Clostridia,36DKK@31979|Clostridiaceae	186801|Clostridia	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit	rpsD	-	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S4,S4
HKD2_k127_5671426_0	1121335.Clst_2503	7.102e-156	496.0	COG0202@1|root,COG0202@2|Bacteria,1TPR8@1239|Firmicutes,248DS@186801|Clostridia,3WGUM@541000|Ruminococcaceae	186801|Clostridia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA	-	2.7.7.6	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L
HKD2_k127_5671426_6	1294142.CINTURNW_0082	2.693e-53	189.0	COG0203@1|root,COG0203@2|Bacteria,1V6JQ@1239|Firmicutes,24J9T@186801|Clostridia,36IQ8@31979|Clostridiaceae	186801|Clostridia	J	Ribosomal protein L17	rplQ	-	-	ko:K02879	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L17
HKD2_k127_5671426_1	1304880.JAGB01000003_gene1182	5.564e-126	408.0	COG1122@1|root,COG1122@2|Bacteria,1TPH8@1239|Firmicutes,248A2@186801|Clostridia	186801|Clostridia	P	ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates	ecfA	-	-	ko:K16786,ko:K16787	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	ABC_tran
HKD2_k127_5671426_3	1410653.JHVC01000010_gene3468	1.034e-105	350.0	COG1122@1|root,COG1122@2|Bacteria,1TPH8@1239|Firmicutes,248A2@186801|Clostridia,36F0E@31979|Clostridiaceae	186801|Clostridia	P	ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates	ecfA	-	-	ko:K16786,ko:K16787	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	ABC_tran
HKD2_k127_5671426_2	1304284.L21TH_0925	1.501e-108	357.0	COG0619@1|root,COG0619@2|Bacteria,1TQ0E@1239|Firmicutes,248AB@186801|Clostridia,36FFB@31979|Clostridiaceae	186801|Clostridia	P	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates	ecfT	-	-	ko:K16783,ko:K16785	ko02010,map02010	M00581,M00582	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.25,3.A.1.25.1,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	CbiQ
HKD2_k127_5671426_5	857293.CAAU_1193	1.741e-57	204.0	COG0101@1|root,COG0101@2|Bacteria,1TQUY@1239|Firmicutes,248W2@186801|Clostridia,36DP0@31979|Clostridiaceae	186801|Clostridia	J	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs	truA	-	5.4.99.12	ko:K06173	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PseudoU_synth_1
HKD2_k127_5691502_7	580331.Thit_0089	3.596e-31	124.0	COG1774@1|root,COG1774@2|Bacteria,1TP1V@1239|Firmicutes,247Q6@186801|Clostridia,42ETV@68295|Thermoanaerobacterales	186801|Clostridia	S	PSP1 domain protein	yaaT	-	-	-	-	-	-	-	-	-	-	-	PSP1
HKD2_k127_5691502_2	1304284.L21TH_0866	5.923e-67	243.0	COG2812@1|root,COG2812@2|Bacteria,1VCQC@1239|Firmicutes,248U4@186801|Clostridia,36UHP@31979|Clostridiaceae	186801|Clostridia	L	DNA polymerase III	holB	-	2.7.7.7	ko:K02341	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNApol3-delta_C
HKD2_k127_5691502_6	509191.AEDB02000043_gene4862	2.594e-33	133.0	COG1728@1|root,COG1728@2|Bacteria,1VF6M@1239|Firmicutes,24S6C@186801|Clostridia,3WP37@541000|Ruminococcaceae	186801|Clostridia	S	Protein of unknown function (DUF327)	-	-	-	ko:K09770	-	-	-	-	ko00000	-	-	-	DUF327
HKD2_k127_5691502_5	1487921.DP68_00045	3.52e-40	151.0	COG3870@1|root,COG3870@2|Bacteria,1V6NI@1239|Firmicutes,24N37@186801|Clostridia,36JI0@31979|Clostridiaceae	186801|Clostridia	S	Cyclic-di-AMP receptor	yaaQ	-	-	-	-	-	-	-	-	-	-	-	CdAMP_rec
HKD2_k127_5691502_0	293826.Amet_0081	1.605e-136	449.0	COG1982@1|root,COG1982@2|Bacteria,1TNZ9@1239|Firmicutes,247RA@186801|Clostridia,36DPH@31979|Clostridiaceae	186801|Clostridia	E	Orn Lys Arg decarboxylase major	-	-	4.1.1.19	ko:K01585	ko00330,ko01100,map00330,map01100	M00133	R00566	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	OKR_DC_1,OKR_DC_1_C
HKD2_k127_5691502_3	273068.TTE0076	8.799e-67	232.0	COG1838@1|root,COG1838@2|Bacteria,1V1CP@1239|Firmicutes,24FRK@186801|Clostridia,42FEX@68295|Thermoanaerobacterales	186801|Clostridia	C	TIGRFAM hydro-lyase, Fe-S type, tartrate fumarate subfamily, beta subunit	fumB	-	4.2.1.2	ko:K01678	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumerase_C
HKD2_k127_5691502_1	203119.Cthe_3090	3.146e-117	383.0	COG1951@1|root,COG1951@2|Bacteria,1TPXQ@1239|Firmicutes,248T7@186801|Clostridia,3WH30@541000|Ruminococcaceae	186801|Clostridia	C	Hydrolyase, tartrate alpha subunit fumarate domain protein, Fe-S type	-	-	4.2.1.2	ko:K01677	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumerase
HKD2_k127_5691502_4	273068.TTE0022	7.047e-61	223.0	COG0628@1|root,COG0628@2|Bacteria,1TS4S@1239|Firmicutes,248E5@186801|Clostridia,42FZD@68295|Thermoanaerobacterales	186801|Clostridia	S	TIGRFAM Sporulation integral membrane protein YtvI	ytvI	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
HKD2_k127_5691502_8	1449063.JMLS01000013_gene5978	1.591e-05	47.0	2DJMR@1|root,306KE@2|Bacteria,1TZYH@1239|Firmicutes,4I982@91061|Bacilli,2715K@186822|Paenibacillaceae	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5739275_2	748727.CLJU_c15610	1.98e-70	250.0	2DBIQ@1|root,2Z9GR@2|Bacteria,1USK2@1239|Firmicutes,25DH0@186801|Clostridia,36UB7@31979|Clostridiaceae	186801|Clostridia	S	Spore germination B3/ GerAC like, C-terminal	-	-	-	ko:K06308	-	-	-	-	ko00000	-	-	-	Spore_GerAC
HKD2_k127_5739275_3	1230342.CTM_19424	4.712e-69	248.0	COG0531@1|root,COG0531@2|Bacteria,1V1FX@1239|Firmicutes,24BQY@186801|Clostridia,36H4F@31979|Clostridiaceae	186801|Clostridia	E	Spore germination protein	-	-	-	-	-	-	-	-	-	-	-	-	Spore_permease
HKD2_k127_5739275_0	1230342.CTM_19429	2.865e-144	473.0	COG0697@1|root,COG0697@2|Bacteria,1TP7K@1239|Firmicutes,24BPE@186801|Clostridia,36H2K@31979|Clostridiaceae	186801|Clostridia	EG	Bacillus/Clostridium GerA spore germination protein	-	-	-	-	-	-	-	-	-	-	-	-	GerA
HKD2_k127_5739275_1	580340.Tlie_1512	1.298e-79	273.0	COG0388@1|root,COG0388@2|Bacteria,3TA0U@508458|Synergistetes	2|Bacteria	S	PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase	cnhA	-	3.5.1.3	ko:K11206,ko:K13566	ko00250,map00250	-	R00269,R00348	RC00010	ko00000,ko00001,ko01000	-	-	-	CN_hydrolase
HKD2_k127_5739491_3	858215.Thexy_1740	2.02e-130	419.0	COG0673@1|root,COG0673@2|Bacteria,1TP83@1239|Firmicutes,248XQ@186801|Clostridia,42FBK@68295|Thermoanaerobacterales	186801|Clostridia	S	Oxidoreductase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
HKD2_k127_5739491_2	580331.Thit_0179	1.271e-186	587.0	COG0673@1|root,COG0673@2|Bacteria,1TNYR@1239|Firmicutes,24DRP@186801|Clostridia,42F4F@68295|Thermoanaerobacterales	186801|Clostridia	S	Oxidoreductase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
HKD2_k127_5739491_0	641107.CDLVIII_4795	1.707e-266	831.0	COG0246@1|root,COG0246@2|Bacteria,1TQ97@1239|Firmicutes,247TG@186801|Clostridia,36E50@31979|Clostridiaceae	186801|Clostridia	G	PFAM Mannitol dehydrogenase, C-terminal domain	-	-	1.1.1.57	ko:K00040	ko00040,ko01100,map00040,map01100	M00061	R02454	RC00085	ko00000,ko00001,ko00002,ko01000	-	-	-	Mannitol_dh,Mannitol_dh_C
HKD2_k127_5739491_1	1123405.AUMM01000020_gene2940	1.433e-189	597.0	COG1312@1|root,COG1312@2|Bacteria,1TP5F@1239|Firmicutes,4H9UR@91061|Bacilli	91061|Bacilli	G	Catalyzes the dehydration of D-mannonate	uxuA	GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005975,GO:0005996,GO:0006063,GO:0006064,GO:0006082,GO:0008150,GO:0008152,GO:0008198,GO:0008927,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0016829,GO:0016835,GO:0016836,GO:0019585,GO:0019752,GO:0030145,GO:0032787,GO:0042839,GO:0042840,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046365,GO:0046395,GO:0046872,GO:0046914,GO:0071704,GO:0072329,GO:1901575	4.2.1.8	ko:K01686	ko00040,ko01100,map00040,map01100	M00061	R05606	RC00543	ko00000,ko00001,ko00002,ko01000	-	-	-	UxuA
HKD2_k127_5739491_4	1122919.KB905571_gene3062	7.089e-18	84.0	COG2207@1|root,COG2207@2|Bacteria,1UJF4@1239|Firmicutes,4IT7N@91061|Bacilli	91061|Bacilli	K	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	AraC_binding,HTH_18
HKD2_k127_5750680_1	1195236.CTER_0264	1.244e-149	482.0	COG2972@1|root,COG2972@2|Bacteria,1TPVR@1239|Firmicutes,247XB@186801|Clostridia	186801|Clostridia	T	Histidine kinase	-	-	2.7.13.3	ko:K07718	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,His_kinase,dCache_1
HKD2_k127_5750680_0	1195236.CTER_0265	3.127e-181	581.0	COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1V1XR@1239|Firmicutes,24H6H@186801|Clostridia	186801|Clostridia	K	PFAM Response regulator receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18,Response_reg
HKD2_k127_5750680_2	1195236.CTER_0266	2.702e-136	443.0	COG1879@1|root,COG1879@2|Bacteria,1V66Z@1239|Firmicutes,24HDK@186801|Clostridia	186801|Clostridia	G	Periplasmic binding protein domain	-	-	-	ko:K10439	ko02010,ko02030,map02010,map02030	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	Peripla_BP_4
HKD2_k127_5760056_5	1069080.KB913028_gene1420	2.549e-173	548.0	COG0191@1|root,COG0191@2|Bacteria,1TQ01@1239|Firmicutes,4H28N@909932|Negativicutes	909932|Negativicutes	G	aldolase class II	fba	-	4.1.2.13	ko:K01624	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167,M00344,M00345	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	F_bP_aldolase
HKD2_k127_5760056_18	1033810.HLPCO_000903	1.344e-55	199.0	COG1670@1|root,COG1670@2|Bacteria	2|Bacteria	J	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins	yokL3	-	2.3.1.57	ko:K00657,ko:K07023	ko00330,ko01100,ko04216,map00330,map01100,map04216	M00135	R01154	RC00004,RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetyltransf_3
HKD2_k127_5760056_23	1121438.JNJA01000003_gene3022	4.665e-18	89.0	COG1433@1|root,COG1433@2|Bacteria,1N8RP@1224|Proteobacteria,42W3C@68525|delta/epsilon subdivisions,2WRJB@28221|Deltaproteobacteria,2MDB5@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Putative redox-active protein (C_GCAxxG_C_C)	-	-	-	-	-	-	-	-	-	-	-	-	C_GCAxxG_C_C
HKD2_k127_5760056_19	1408254.T458_18130	1.523e-47	180.0	COG2267@1|root,COG2267@2|Bacteria,1UZ5S@1239|Firmicutes,4HEHP@91061|Bacilli,275E1@186822|Paenibacillaceae	91061|Bacilli	I	Serine aminopeptidase, S33	-	-	3.1.1.5	ko:K01048	ko00564,map00564	-	-	-	ko00000,ko00001,ko01000	-	-	-	Hydrolase_4
HKD2_k127_5760056_22	1128398.Curi_c12430	2.963e-20	97.0	2DQ8Z@1|root,335CG@2|Bacteria,1V9R5@1239|Firmicutes,24JTW@186801|Clostridia,26992@186813|unclassified Clostridiales	186801|Clostridia	S	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5760056_15	1195236.CTER_1869	2.44e-65	229.0	COG0484@1|root,COG0484@2|Bacteria,1V6FQ@1239|Firmicutes,25F3F@186801|Clostridia,3WRDA@541000|Ruminococcaceae	186801|Clostridia	O	DnaJ molecular chaperone homology domain	-	-	-	-	-	-	-	-	-	-	-	-	DnaJ
HKD2_k127_5760056_7	1291050.JAGE01000001_gene2756	4.902e-83	285.0	2CC4I@1|root,2Z8PZ@2|Bacteria,1TQTT@1239|Firmicutes,24AJ3@186801|Clostridia,3WINQ@541000|Ruminococcaceae	186801|Clostridia	S	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5760056_2	1121289.JHVL01000017_gene763	3.756e-268	831.0	COG0554@1|root,COG0554@2|Bacteria,1TPX3@1239|Firmicutes,2493W@186801|Clostridia,36EMF@31979|Clostridiaceae	186801|Clostridia	F	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate	glpK	GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615	2.7.1.30	ko:K00864	ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626	-	R00847	RC00002,RC00017	ko00000,ko00001,ko01000,ko04147	-	-	-	FGGY_C,FGGY_N
HKD2_k127_5760056_21	1031288.AXAA01000022_gene1581	2.235e-35	150.0	COG0477@1|root,COG2814@2|Bacteria,1UZPE@1239|Firmicutes,2490R@186801|Clostridia,36EGS@31979|Clostridiaceae	186801|Clostridia	EGP	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_2,MFS_3
HKD2_k127_5760056_3	180332.JTGN01000027_gene1760	1.522e-191	620.0	COG0210@1|root,COG0210@2|Bacteria,1UGJW@1239|Firmicutes,24B56@186801|Clostridia	186801|Clostridia	L	UvrD-like helicase C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	UvrD-helicase,UvrD_C
HKD2_k127_5760056_0	941824.TCEL_01065	0.0	1137.0	COG1061@1|root,COG1205@1|root,COG1061@2|Bacteria,COG1205@2|Bacteria,1TSPA@1239|Firmicutes,25EG8@186801|Clostridia,36UPK@31979|Clostridiaceae	186801|Clostridia	L	Domain of unknown function (DUF1998)	-	-	-	ko:K06877	-	-	-	-	ko00000	-	-	-	DEAD,DUF1998,Helicase_C
HKD2_k127_5760056_20	97138.C820_02121	8.687e-37	143.0	COG0593@1|root,COG0593@2|Bacteria,1VAFE@1239|Firmicutes,25E3U@186801|Clostridia,36JPD@31979|Clostridiaceae	186801|Clostridia	L	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5760056_10	768706.Desor_3968	3.069e-81	283.0	COG0006@1|root,COG0006@2|Bacteria,1TQ6R@1239|Firmicutes,25CCC@186801|Clostridia,264Q5@186807|Peptococcaceae	186801|Clostridia	E	Belongs to the peptidase M24B family	pepQ	-	3.4.13.9	ko:K01271	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Peptidase_M24
HKD2_k127_5760056_6	941824.TCEL_00120	1.095e-101	343.0	COG0438@1|root,COG0438@2|Bacteria,1UASH@1239|Firmicutes,248VW@186801|Clostridia,36E4C@31979|Clostridiaceae	186801|Clostridia	M	glycosyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
HKD2_k127_5760056_11	555079.Toce_0826	4.092e-81	279.0	COG1723@1|root,COG1723@2|Bacteria,1TQMD@1239|Firmicutes,24CG0@186801|Clostridia	186801|Clostridia	S	PFAM Uncharacterised ACR, YagE family COG1723	-	-	-	-	-	-	-	-	-	-	-	-	DUF155
HKD2_k127_5760056_24	748449.Halha_1443	2.229e-09	61.0	2EGDT@1|root,33A5P@2|Bacteria,1VKCR@1239|Firmicutes	1239|Firmicutes	S	asparagine synthase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5760056_12	632335.Calkr_0141	1.017e-77	263.0	COG1592@1|root,COG1592@2|Bacteria,1V1FF@1239|Firmicutes,248V2@186801|Clostridia,42GAI@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM Rubrerythrin	rbr	GO:0003674,GO:0003824,GO:0004601,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009636,GO:0009987,GO:0016209,GO:0016491,GO:0016684,GO:0016692,GO:0022900,GO:0042221,GO:0044237,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
HKD2_k127_5760056_26	1282887.AUJG01000003_gene576	5.061e-05	52.0	COG2306@1|root,COG2306@2|Bacteria,1VD0J@1239|Firmicutes,24MAM@186801|Clostridia	186801|Clostridia	S	Protein of unknown function (DUF402)	-	-	-	ko:K07586	-	-	-	-	ko00000	-	-	-	DUF402
HKD2_k127_5760056_4	1408422.JHYF01000014_gene164	1.217e-188	601.0	COG1640@1|root,COG1640@2|Bacteria,1W5VQ@1239|Firmicutes,25E46@186801|Clostridia,36DWR@31979|Clostridiaceae	186801|Clostridia	G	4-alpha-glucanotransferase	malQ	-	2.4.1.25	ko:K00705	ko00500,ko01100,map00500,map01100	-	R05196	RC00049	ko00000,ko00001,ko01000	-	GH77	-	Glyco_hydro_77
HKD2_k127_5760056_1	1304284.L21TH_1164	2.284e-276	860.0	COG0058@1|root,COG0058@2|Bacteria,1TQAJ@1239|Firmicutes,248E1@186801|Clostridia,36E5W@31979|Clostridiaceae	186801|Clostridia	G	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties	glgP2	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	DUF3417,Glyco_transf_5,Phosphorylase
HKD2_k127_5760056_8	1121324.CLIT_13c00360	6.413e-83	278.0	COG2316@1|root,COG2316@2|Bacteria,1TSF7@1239|Firmicutes,24A1B@186801|Clostridia	186801|Clostridia	S	PFAM metal-dependent phosphohydrolase, HD sub domain	-	-	-	ko:K06951	-	-	-	-	ko00000	-	-	-	HD
HKD2_k127_5760056_16	857293.CAAU_2159	1.131e-62	220.0	COG1956@1|root,COG1956@2|Bacteria,1V6GQ@1239|Firmicutes,24J9S@186801|Clostridia,36IYQ@31979|Clostridiaceae	186801|Clostridia	T	GAF domain	-	-	1.8.4.14	ko:K08968	ko00270,map00270	-	R02025	RC00639	ko00000,ko00001,ko01000	-	-	-	GAF,GAF_2
HKD2_k127_5760056_14	756499.Desde_1722	1.216e-70	244.0	COG2094@1|root,COG2094@2|Bacteria,1V1E6@1239|Firmicutes,24FRV@186801|Clostridia,261K2@186807|Peptococcaceae	186801|Clostridia	L	Belongs to the DNA glycosylase MPG family	-	-	3.2.2.21	ko:K03652	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Pur_DNA_glyco
HKD2_k127_5760056_9	1499689.CCNN01000013_gene3032	2.432e-81	276.0	28JAU@1|root,2Z95P@2|Bacteria,1UPNR@1239|Firmicutes,25HK6@186801|Clostridia,36IBI@31979|Clostridiaceae	186801|Clostridia	S	Mpv17 / PMP22 family	-	-	-	-	-	-	-	-	-	-	-	-	Mpv17_PMP22
HKD2_k127_5760056_17	509191.AEDB02000022_gene2946	3.026e-59	212.0	COG1285@1|root,COG1285@2|Bacteria,1V409@1239|Firmicutes,249SQ@186801|Clostridia,3WJXI@541000|Ruminococcaceae	186801|Clostridia	S	MgtC family	-	-	-	ko:K07507	-	-	-	-	ko00000,ko02000	9.B.20	-	-	ACT,MgtC
HKD2_k127_5760056_13	1031288.AXAA01000003_gene1671	6.398e-72	252.0	COG0115@1|root,COG0115@2|Bacteria,1TPY2@1239|Firmicutes,25930@186801|Clostridia,36DVP@31979|Clostridiaceae	186801|Clostridia	EH	Aminotransferase class IV	ilvE2	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
HKD2_k127_5760056_25	1444310.JANV01000124_gene2944	1.943e-06	49.0	COG3048@1|root,COG3048@2|Bacteria,1TPAH@1239|Firmicutes,4HANC@91061|Bacilli,1ZASU@1386|Bacillus	91061|Bacilli	E	Belongs to the serine threonine dehydratase family. DsdA subfamily	dsdA	GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008721,GO:0009987,GO:0016829,GO:0016840,GO:0016841,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0071704,GO:1901564	4.3.1.18	ko:K01753	ko00260,map00260	-	R00221	RC02600	ko00000,ko00001,ko01000	-	-	-	PALP
HKD2_k127_5761653_7	1410653.JHVC01000036_gene3607	2.374e-72	244.0	COG2133@1|root,COG2133@2|Bacteria,1TR38@1239|Firmicutes,248E0@186801|Clostridia,36DXQ@31979|Clostridiaceae	186801|Clostridia	G	Glucose sorbosone	-	-	-	-	-	-	-	-	-	-	-	-	GSDH
HKD2_k127_5761653_0	394503.Ccel_1662	2.343e-209	655.0	COG0738@1|root,COG0738@2|Bacteria,1TPB5@1239|Firmicutes,24913@186801|Clostridia,36GA9@31979|Clostridiaceae	186801|Clostridia	G	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD2_k127_5761653_9	1007103.AFHW01000001_gene4864	1.011e-10	66.0	2BW9X@1|root,33N53@2|Bacteria,1VM1B@1239|Firmicutes,4IACI@91061|Bacilli,272ND@186822|Paenibacillaceae	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5761653_3	1321778.HMPREF1982_02853	5.908e-174	555.0	COG4188@1|root,COG4188@2|Bacteria,1V0PK@1239|Firmicutes,24C18@186801|Clostridia	186801|Clostridia	S	Platelet-activating factor acetylhydrolase, isoform II	-	-	-	-	-	-	-	-	-	-	-	-	PAF-AH_p_II
HKD2_k127_5761653_5	1321778.HMPREF1982_01472	1.02e-107	351.0	COG2197@1|root,COG2197@2|Bacteria,1TQ1U@1239|Firmicutes,25B1X@186801|Clostridia,26CPI@186813|unclassified Clostridiales	186801|Clostridia	T	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HKD2_k127_5761653_4	1321778.HMPREF1982_01471	3.185e-158	505.0	COG4585@1|root,COG4585@2|Bacteria,1UUZ9@1239|Firmicutes,248T2@186801|Clostridia	186801|Clostridia	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
HKD2_k127_5761653_1	1321778.HMPREF1982_01470	1.587e-182	574.0	COG1131@1|root,COG1131@2|Bacteria,1TPMQ@1239|Firmicutes,248QD@186801|Clostridia	186801|Clostridia	V	Abc transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
HKD2_k127_5761653_8	1104325.M7W_2424	1.257e-44	176.0	COG0842@1|root,COG0842@2|Bacteria,1TR76@1239|Firmicutes,4HN4S@91061|Bacilli,4B0VB@81852|Enterococcaceae	91061|Bacilli	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
HKD2_k127_5761653_2	1321778.HMPREF1982_01468	4.379e-174	553.0	COG0842@1|root,COG0842@2|Bacteria,1UYEY@1239|Firmicutes,24BCP@186801|Clostridia	186801|Clostridia	V	Psort location CytoplasmicMembrane, score	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
HKD2_k127_5761653_6	469618.FVAG_00099	5.957e-84	291.0	COG1388@1|root,COG1388@2|Bacteria,378A0@32066|Fusobacteria	32066|Fusobacteria	M	LysM domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5761653_10	316274.Haur_0968	2.957e-10	72.0	COG2385@1|root,COG3409@1|root,COG2385@2|Bacteria,COG3409@2|Bacteria	2|Bacteria	M	Peptidoglycan-binding domain 1 protein	-	-	3.2.1.132	ko:K01233,ko:K21449	ko00520,ko01100,map00520,map01100	-	R02833	-	ko00000,ko00001,ko01000,ko02000	1.B.40.2	-	-	ChW,Muraidase,PG_binding_1,SpoIID
HKD2_k127_5766909_3	1117108.PAALTS15_29321	0.0001668	44.0	2BIX5@1|root,32D5C@2|Bacteria,1TYU1@1239|Firmicutes,4HQP1@91061|Bacilli,26YC3@186822|Paenibacillaceae	91061|Bacilli	S	Phosphotransferase enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	APH
HKD2_k127_5766909_1	180332.JTGN01000007_gene3663	2.738e-67	233.0	COG1670@1|root,COG1670@2|Bacteria,1VCQX@1239|Firmicutes	1239|Firmicutes	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
HKD2_k127_5766909_0	1321778.HMPREF1982_02373	1.03e-121	391.0	COG0655@1|root,COG0655@2|Bacteria,1V2A8@1239|Firmicutes,24G7D@186801|Clostridia	186801|Clostridia	S	NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
HKD2_k127_5766909_2	580327.Tthe_2004	5.975e-07	53.0	COG2333@1|root,COG2333@2|Bacteria,1TS9U@1239|Firmicutes,249VR@186801|Clostridia,42EVU@68295|Thermoanaerobacterales	186801|Clostridia	S	beta-lactamase domain protein	-	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Ada_Zn_binding,LTD,Lactamase_B
HKD2_k127_5778438_2	272562.CA_C3264	6.976e-36	139.0	COG3874@1|root,COG3874@2|Bacteria,1V99U@1239|Firmicutes,24K00@186801|Clostridia,36KEV@31979|Clostridiaceae	186801|Clostridia	S	PFAM Sporulation protein YtfJ	-	-	-	-	-	-	-	-	-	-	-	-	Spore_YtfJ
HKD2_k127_5778438_4	1395587.P364_0126210	9.185e-06	54.0	2EBE8@1|root,335EW@2|Bacteria,1VI0V@1239|Firmicutes,4HQUP@91061|Bacilli,26ZQD@186822|Paenibacillaceae	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5778438_0	515635.Dtur_0172	5.078e-146	478.0	COG5434@1|root,COG5434@2|Bacteria	2|Bacteria	M	polygalacturonase activity	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,Glyco_hydro_28,Pectate_lyase_3
HKD2_k127_5778438_3	1536769.P40081_08340	7.396e-32	132.0	COG5434@1|root,COG5434@2|Bacteria,1UV7F@1239|Firmicutes,4I6T5@91061|Bacilli,26UT0@186822|Paenibacillaceae	91061|Bacilli	M	Pectate lyase superfamily protein	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,CBM_6,F5_F8_type_C,Pectate_lyase_3
HKD2_k127_5778438_1	1321778.HMPREF1982_02387	3.705e-56	197.0	COG1609@1|root,COG1609@2|Bacteria,1TS5M@1239|Firmicutes,24AWP@186801|Clostridia,26CHE@186813|unclassified Clostridiales	186801|Clostridia	K	helix_turn _helix lactose operon repressor	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
HKD2_k127_5790548_3	1230342.CTM_10206	5.61e-44	164.0	COG1959@1|root,COG1959@2|Bacteria,1V3QB@1239|Firmicutes,24JIV@186801|Clostridia,36JGE@31979|Clostridiaceae	186801|Clostridia	K	Rrf2 family	-	-	-	-	-	-	-	-	-	-	-	-	Rrf2
HKD2_k127_5790548_1	632292.Calhy_1569	2.898e-162	515.0	COG0031@1|root,COG0031@2|Bacteria,1TP30@1239|Firmicutes,2497G@186801|Clostridia,42F5Y@68295|Thermoanaerobacterales	186801|Clostridia	E	Belongs to the cysteine synthase cystathionine beta- synthase family	cysK	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HKD2_k127_5790548_4	1321778.HMPREF1982_04598	3.312e-29	121.0	COG4892@1|root,COG4892@2|Bacteria,1VEGK@1239|Firmicutes,24QJ4@186801|Clostridia	186801|Clostridia	G	PFAM cytochrome	-	-	-	-	-	-	-	-	-	-	-	-	Cyt-b5
HKD2_k127_5790548_2	536232.CLM_1998	8.157e-129	417.0	COG1740@1|root,COG1740@2|Bacteria,1TZZD@1239|Firmicutes,2489B@186801|Clostridia,36EWC@31979|Clostridiaceae	186801|Clostridia	C	Hydrogenase (NiFe) small subunit HydA	hupS	-	1.12.99.6	ko:K06282	ko00633,ko01120,map00633,map01120	-	R08034	RC00250	ko00000,ko00001,ko01000	-	-	-	NiFe_hyd_SSU_C,Oxidored_q6,TAT_signal
HKD2_k127_5790548_0	1487921.DP68_01140	1.42e-180	576.0	COG0374@1|root,COG0374@2|Bacteria,1TQMW@1239|Firmicutes,248BB@186801|Clostridia,36F7N@31979|Clostridiaceae	186801|Clostridia	C	Belongs to the NiFe NiFeSe hydrogenase large subunit family	hupL	-	1.12.99.6	ko:K06281	ko00633,ko01120,map00633,map01120	-	R08034	RC00250	ko00000,ko00001,ko01000	-	-	-	NiFeSe_Hases
HKD2_k127_5790548_5	1540257.JQMW01000004_gene580	5.64e-21	98.0	COG0680@1|root,COG0680@2|Bacteria,1VE76@1239|Firmicutes,24S2H@186801|Clostridia,36MUP@31979|Clostridiaceae	186801|Clostridia	C	hydrogenase maturation protease	-	-	-	ko:K03605	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	HycI
HKD2_k127_5830712_5	536227.CcarbDRAFT_2338	5.049e-08	54.0	COG0531@1|root,COG0531@2|Bacteria,1UF40@1239|Firmicutes,25EVI@186801|Clostridia,36UB5@31979|Clostridiaceae	186801|Clostridia	E	TIGRFAM spore germination protein	-	-	-	ko:K06296	-	-	-	-	ko00000,ko02000	2.A.3.9.3	-	-	Spore_permease
HKD2_k127_5830712_2	545695.TREAZ_2097	1.047e-55	202.0	28M3X@1|root,2ZAHZ@2|Bacteria,2JB7I@203691|Spirochaetes	203691|Spirochaetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5830712_3	1274374.CBLK010000059_gene414	2.476e-38	146.0	COG1937@1|root,COG1937@2|Bacteria,1VEF5@1239|Firmicutes,4HJ3J@91061|Bacilli,2751S@186822|Paenibacillaceae	91061|Bacilli	S	Metal-sensitive transcriptional repressor	csoR_2	-	-	ko:K21600	-	-	-	-	ko00000,ko03000	-	-	-	Trns_repr_metal
HKD2_k127_5830712_4	350688.Clos_0055	2.765e-22	97.0	COG2608@1|root,COG2608@2|Bacteria,1VK5F@1239|Firmicutes,24RMA@186801|Clostridia,36P1S@31979|Clostridiaceae	186801|Clostridia	P	Heavy metal transport detoxification protein	copZ	-	-	ko:K07213	ko04978,map04978	-	-	-	ko00000,ko00001	-	-	-	HMA
HKD2_k127_5830712_0	610130.Closa_2579	0.0	1116.0	COG2217@1|root,COG2217@2|Bacteria,1TP5S@1239|Firmicutes,247MW@186801|Clostridia,21Y6P@1506553|Lachnoclostridium	186801|Clostridia	P	Heavy-metal-associated domain	-	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
HKD2_k127_5830712_1	1195236.CTER_4386	3.016e-283	878.0	COG0495@1|root,COG0495@2|Bacteria,1TP0Y@1239|Firmicutes,2484Y@186801|Clostridia,3WH0P@541000|Ruminococcaceae	186801|Clostridia	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
HKD2_k127_58340_2	573061.Clocel_2263	1.514e-142	454.0	COG3717@1|root,COG3717@2|Bacteria,1TP4X@1239|Firmicutes,24A00@186801|Clostridia,36FCR@31979|Clostridiaceae	186801|Clostridia	G	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate	kduI	-	5.3.1.17	ko:K01815	ko00040,map00040	-	R04383	RC00541	ko00000,ko00001,ko01000	-	-	-	KduI
HKD2_k127_58340_5	86416.Clopa_4422	5.708e-61	213.0	COG2731@1|root,COG2731@2|Bacteria,1VCI9@1239|Firmicutes,24QNC@186801|Clostridia,36NJ1@31979|Clostridiaceae	186801|Clostridia	G	protein, YhcH YjgK YiaL family	-	-	-	-	-	-	-	-	-	-	-	-	DUF386
HKD2_k127_58340_1	641107.CDLVIII_4406	9.143e-244	758.0	COG3069@1|root,COG3069@2|Bacteria,1TQVU@1239|Firmicutes,24C4I@186801|Clostridia,36GA8@31979|Clostridiaceae	186801|Clostridia	C	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_58340_0	641107.CDLVIII_4405	0.0	1247.0	COG0145@1|root,COG0145@2|Bacteria,1TQVB@1239|Firmicutes,24AJ7@186801|Clostridia,36G7J@31979|Clostridiaceae	186801|Clostridia	EQ	PFAM Hydantoinase oxoprolinase	-	-	-	-	-	-	-	-	-	-	-	-	Hydant_A_N,Hydantoinase_A
HKD2_k127_58340_4	641107.CDLVIII_4404	1.679e-105	346.0	COG0145@1|root,COG0145@2|Bacteria,1V3BH@1239|Firmicutes,24H6U@186801|Clostridia,36J3E@31979|Clostridiaceae	186801|Clostridia	EQ	ligase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_58340_3	641107.CDLVIII_4403	1.31e-115	375.0	COG1802@1|root,COG1802@2|Bacteria,1V3SB@1239|Firmicutes,24EKV@186801|Clostridia,36GMN@31979|Clostridiaceae	186801|Clostridia	K	PFAM regulatory protein GntR HTH	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
HKD2_k127_58340_6	632292.Calhy_0733	6.442e-23	104.0	COG1396@1|root,COG1396@2|Bacteria	2|Bacteria	K	sequence-specific DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	HTH_19,HTH_3
HKD2_k127_5845843_5	1499689.CCNN01000006_gene603	1.38e-82	285.0	COG3276@1|root,COG3276@2|Bacteria,1TPQS@1239|Firmicutes,2484U@186801|Clostridia,36E0X@31979|Clostridiaceae	186801|Clostridia	J	translation elongation factor	selB	-	-	ko:K03833	-	-	-	-	ko00000,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,SelB-wing_2,SelB-wing_3
HKD2_k127_5845843_10	1121430.JMLG01000003_gene643	4.534e-28	123.0	COG0860@1|root,COG0860@2|Bacteria,1UYPW@1239|Firmicutes,24BHU@186801|Clostridia,262B5@186807|Peptococcaceae	186801|Clostridia	M	PFAM cell wall hydrolase autolysin	-	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	Amidase_3,CW_binding_2,SH3_3,SPOR
HKD2_k127_5845843_4	509191.AEDB02000023_gene3570	3.985e-109	361.0	COG2204@1|root,COG2204@2|Bacteria,1VSKG@1239|Firmicutes,24ZP4@186801|Clostridia,3WSMG@541000|Ruminococcaceae	186801|Clostridia	T	Bacterial regulatory protein, Fis family	zraR	-	-	ko:K02481,ko:K07714,ko:K10943	ko02020,ko05111,map02020,map05111	M00500,M00515	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD2_k127_5845843_0	580331.Thit_1841	6.08e-249	809.0	COG2114@1|root,COG3899@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,1TRVU@1239|Firmicutes,25BEN@186801|Clostridia,42HV6@68295|Thermoanaerobacterales	186801|Clostridia	LOT	PFAM adenylyl cyclase class-3 4 guanylyl cyclase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,Guanylate_cyc,TPR_12,TPR_8
HKD2_k127_5845843_2	509191.AEDB02000023_gene3580	1.272e-150	496.0	COG2203@1|root,COG4585@1|root,COG2203@2|Bacteria,COG4585@2|Bacteria,1UVSI@1239|Firmicutes,25JK3@186801|Clostridia,3WNT5@541000|Ruminococcaceae	186801|Clostridia	T	GAF domain	-	-	2.7.13.3	ko:K07777	ko02020,map02020	M00478	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	GAF,HATPase_c,HisKA_3
HKD2_k127_5845843_3	398512.JQKC01000006_gene600	9.828e-141	455.0	COG2038@1|root,COG2038@2|Bacteria,1TPC1@1239|Firmicutes,25DH5@186801|Clostridia,3WGSW@541000|Ruminococcaceae	186801|Clostridia	H	Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB)	cobT	-	2.4.2.21	ko:K00768	ko00860,ko01100,map00860,map01100	M00122	R04148	RC00033,RC00063	ko00000,ko00001,ko00002,ko01000	-	-	-	DBI_PRT
HKD2_k127_5845843_8	1443122.Z958_07180	3.033e-56	201.0	COG2087@1|root,COG2087@2|Bacteria,1V6F8@1239|Firmicutes,24JF6@186801|Clostridia,36KXJ@31979|Clostridiaceae	186801|Clostridia	H	cobinamide kinase	cobU	-	2.7.1.156,2.7.7.62	ko:K02231	ko00860,ko01100,map00860,map01100	M00122	R05221,R05222,R06558	RC00002,RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	CobU
HKD2_k127_5845843_6	1443125.Z962_06080	1.324e-78	269.0	COG0368@1|root,COG0368@2|Bacteria,1V1QB@1239|Firmicutes,24I0D@186801|Clostridia,36H10@31979|Clostridiaceae	186801|Clostridia	H	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate	cobS	-	2.7.8.26	ko:K02233	ko00860,ko01100,map00860,map01100	M00122	R05223,R11174	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	CobS
HKD2_k127_5845843_9	592027.CLG_B0995	3.542e-51	188.0	COG0406@1|root,COG0406@2|Bacteria,1VEMM@1239|Firmicutes,24GJW@186801|Clostridia,36KFN@31979|Clostridiaceae	186801|Clostridia	G	Belongs to the phosphoglycerate mutase family	cobC	-	3.1.3.73	ko:K02226	ko00860,ko01100,map00860,map01100	M00122	R04594,R11173	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	His_Phos_1
HKD2_k127_5845843_1	386415.NT01CX_2081	3.146e-205	649.0	COG1492@1|root,COG1492@2|Bacteria,1TP5E@1239|Firmicutes,248XW@186801|Clostridia,36DBM@31979|Clostridiaceae	186801|Clostridia	H	Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation	cobQ	-	6.3.5.10	ko:K02232	ko00860,ko01100,map00860,map01100	M00122	R05225	RC00010,RC01302	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS15780	AAA_26,CbiA,GATase_3
HKD2_k127_5845843_7	1443125.Z962_06065	1.092e-57	205.0	COG1270@1|root,COG1270@2|Bacteria,1TQ3X@1239|Firmicutes,247PR@186801|Clostridia,36ERQ@31979|Clostridiaceae	186801|Clostridia	H	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group	cobD	-	6.3.1.10	ko:K02227	ko00860,ko01100,map00860,map01100	M00122	R06529,R07302	RC00090,RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	CobD_Cbib
HKD2_k127_585103_3	1304284.L21TH_0037	2.312e-63	224.0	COG0671@1|root,COG0818@1|root,COG0671@2|Bacteria,COG0818@2|Bacteria,1VEGR@1239|Firmicutes,248FD@186801|Clostridia,36DSP@31979|Clostridiaceae	186801|Clostridia	IM	Diacylglycerol kinase	dgkA	-	2.7.1.107,2.7.1.66	ko:K00887,ko:K00901	ko00550,ko00561,ko00564,ko01100,ko01110,ko04070,ko04072,ko05231,map00550,map00561,map00564,map01100,map01110,map04070,map04072,map05231	-	R02240,R05626	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	DAGK_prokar,PAP2
HKD2_k127_585103_4	273068.TTE0972	4.813e-43	163.0	COG0319@1|root,COG0319@2|Bacteria,1V6BU@1239|Firmicutes,24MQZ@186801|Clostridia,42GDP@68295|Thermoanaerobacterales	186801|Clostridia	J	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA	ybeY	-	3.5.4.5	ko:K01489,ko:K07042	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01878,R02485,R08221	RC00074,RC00514	ko00000,ko00001,ko01000,ko03009	-	-	-	UPF0054
HKD2_k127_585103_0	1304284.L21TH_0039	2.37e-164	540.0	COG1480@1|root,COG1480@2|Bacteria,1TR1A@1239|Firmicutes,249W0@186801|Clostridia,36E2C@31979|Clostridiaceae	186801|Clostridia	S	SMART Metal-dependent phosphohydrolase, HD region	-	-	-	ko:K07037	-	-	-	-	ko00000	-	-	-	7TM-7TMR_HD,7TMR-HDED,HD
HKD2_k127_585103_1	273068.TTE0970	2.396e-131	426.0	COG1702@1|root,COG1702@2|Bacteria,1TP35@1239|Firmicutes,247ZJ@186801|Clostridia,42EZD@68295|Thermoanaerobacterales	186801|Clostridia	T	PFAM PhoH family protein	phoH	-	-	ko:K06217	-	-	-	-	ko00000	-	-	-	PhoH
HKD2_k127_585103_2	720554.Clocl_1430	4.485e-75	267.0	COG0561@1|root,COG0561@2|Bacteria,1TR3N@1239|Firmicutes,24ACD@186801|Clostridia,3WJNK@541000|Ruminococcaceae	186801|Clostridia	S	sporulation protein	yqfD	-	-	ko:K06438	-	-	-	-	ko00000	-	-	-	YqfD
HKD2_k127_585103_6	580331.Thit_0916	5.763e-19	89.0	2E4EZ@1|root,32ZA5@2|Bacteria,1VF5C@1239|Firmicutes,24QWJ@186801|Clostridia,42H5R@68295|Thermoanaerobacterales	186801|Clostridia	S	sporulation protein YqfC	yqfC	-	-	-	-	-	-	-	-	-	-	-	YabP
HKD2_k127_585103_5	1449126.JQKL01000018_gene3301	2.468e-23	100.0	COG4864@1|root,COG4864@2|Bacteria,1TPTD@1239|Firmicutes,24APU@186801|Clostridia,26A0K@186813|unclassified Clostridiales	186801|Clostridia	S	SigmaW regulon antibacterial	-	-	-	-	-	-	-	-	-	-	-	-	YdfA_immunity
HKD2_k127_5856150_9	1449126.JQKL01000050_gene2673	9.899e-13	68.0	COG0050@1|root,COG0050@2|Bacteria,1TPKC@1239|Firmicutes,2485I@186801|Clostridia,267PG@186813|unclassified Clostridiales	186801|Clostridia	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
HKD2_k127_5856150_7	1507.HMPREF0262_03340	6.88e-22	94.0	COG0267@1|root,COG0267@2|Bacteria,1VEJ4@1239|Firmicutes,24QK0@186801|Clostridia,36MJQ@31979|Clostridiaceae	186801|Clostridia	J	Belongs to the bacterial ribosomal protein bL33 family	rpmG	-	-	ko:K02913	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L33
HKD2_k127_5856150_10	1246995.AFR_04420	6.117e-08	57.0	COG0690@1|root,COG0690@2|Bacteria,2GQFP@201174|Actinobacteria,4DF5J@85008|Micromonosporales	201174|Actinobacteria	U	Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation	secE	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	ko:K03073	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecE
HKD2_k127_5856150_2	1230342.CTM_21016	8.23e-79	267.0	COG0250@1|root,COG0250@2|Bacteria,1TR3P@1239|Firmicutes,248XB@186801|Clostridia,36F5J@31979|Clostridiaceae	186801|Clostridia	K	Participates in transcription elongation, termination and antitermination	nusG	-	-	ko:K02601	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KOW,NusG
HKD2_k127_5856150_3	1321778.HMPREF1982_01949	4.308e-70	240.0	COG0080@1|root,COG0080@2|Bacteria,1V1BS@1239|Firmicutes,24FSQ@186801|Clostridia,268Y4@186813|unclassified Clostridiales	186801|Clostridia	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors	rplK	-	-	ko:K02867	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L11,Ribosomal_L11_N
HKD2_k127_5856150_1	1031288.AXAA01000041_gene930	5.804e-116	376.0	COG0081@1|root,COG0081@2|Bacteria,1TPTS@1239|Firmicutes,247JB@186801|Clostridia,36EF5@31979|Clostridiaceae	186801|Clostridia	J	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release	rplA	-	-	ko:K02863	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L1
HKD2_k127_5856150_4	1304284.L21TH_0447	2.447e-46	172.0	COG0244@1|root,COG0244@2|Bacteria,1V3JJ@1239|Firmicutes,24G9R@186801|Clostridia,36I5W@31979|Clostridiaceae	186801|Clostridia	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rplJ	-	-	ko:K02864	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L10
HKD2_k127_5856150_5	1131730.BAVI_08581	5.376e-44	163.0	COG0222@1|root,COG0222@2|Bacteria,1V6EI@1239|Firmicutes,4HIGQ@91061|Bacilli,1ZG84@1386|Bacillus	91061|Bacilli	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation	rplL	-	-	ko:K02935	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L12,Ribosomal_L12_N
HKD2_k127_5856150_6	720554.Clocl_2595	5.821e-23	104.0	COG1989@1|root,COG1989@2|Bacteria,1VFC1@1239|Firmicutes,25DCN@186801|Clostridia,3WSGE@541000|Ruminococcaceae	186801|Clostridia	NOU	Type IV leader peptidase family	-	-	3.4.23.43	ko:K02278	-	-	-	-	ko00000,ko01000,ko02035,ko02044	-	-	-	Peptidase_A24
HKD2_k127_5856150_8	904296.HMPREF9124_2106	1.656e-13	82.0	COG1192@1|root,COG1192@2|Bacteria,1V11K@1239|Firmicutes,24FDX@186801|Clostridia,2PRGU@265975|Oribacterium	186801|Clostridia	D	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	AAA_31
HKD2_k127_5856150_0	720554.Clocl_2853	2.142e-160	512.0	COG4962@1|root,COG4962@2|Bacteria,1TQ0Z@1239|Firmicutes,249VS@186801|Clostridia,3WGJJ@541000|Ruminococcaceae	186801|Clostridia	U	Type II IV secretion system protein	-	-	-	ko:K02283	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
HKD2_k127_58864_3	1211817.CCAT010000012_gene2737	1.019e-104	347.0	COG1079@1|root,COG1079@2|Bacteria,1TP8Y@1239|Firmicutes,2486N@186801|Clostridia,36EJH@31979|Clostridiaceae	186801|Clostridia	S	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
HKD2_k127_58864_2	1120998.AUFC01000001_gene1829	1.67e-146	479.0	COG1508@1|root,COG1508@2|Bacteria,1TQ0H@1239|Firmicutes,2480F@186801|Clostridia,3WD6I@538999|Clostridiales incertae sedis	186801|Clostridia	K	Sigma-54 factor, Activator interacting domain (AID)	rpoN	-	-	ko:K03092	ko02020,ko05111,map02020,map05111	-	-	-	ko00000,ko00001,ko03021	-	-	-	Sigma54_AID,Sigma54_CBD,Sigma54_DBD
HKD2_k127_58864_5	332101.JIBU02000008_gene536	3.876e-90	308.0	COG2390@1|root,COG2390@2|Bacteria,1TP62@1239|Firmicutes,24B2X@186801|Clostridia,36DHS@31979|Clostridiaceae	186801|Clostridia	K	Transcriptional regulator	cggR	-	-	ko:K05311	-	-	-	-	ko00000,ko03000	-	-	-	Sugar-bind
HKD2_k127_58864_1	935948.KE386495_gene1720	3.423e-160	510.0	COG0057@1|root,COG0057@2|Bacteria,1TNYU@1239|Firmicutes,247IZ@186801|Clostridia,42F8D@68295|Thermoanaerobacterales	186801|Clostridia	C	TIGRFAM Glyceraldehyde-3-phosphate dehydrogenase, type I	gap	-	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Gp_dh_C,Gp_dh_N
HKD2_k127_58864_0	697281.Mahau_1480	7.018e-177	561.0	COG0126@1|root,COG0126@2|Bacteria,1TP3H@1239|Firmicutes,248VS@186801|Clostridia,42F8F@68295|Thermoanaerobacterales	186801|Clostridia	F	Belongs to the phosphoglycerate kinase family	pgk	-	2.7.2.3,5.3.1.1	ko:K00927,ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01015,R01512	RC00002,RC00043,RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
HKD2_k127_58864_4	935948.KE386495_gene1722	1.509e-97	324.0	COG0149@1|root,COG0149@2|Bacteria,1TP2F@1239|Firmicutes,248JN@186801|Clostridia,42FAI@68295|Thermoanaerobacterales	186801|Clostridia	G	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)	tpiA	-	5.3.1.1	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01015	RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iHN637.CLJU_RS19265	TIM
HKD2_k127_58864_6	1408422.JHYF01000004_gene1468	1.251e-32	128.0	COG0148@1|root,COG0148@2|Bacteria,1TP2S@1239|Firmicutes,247TU@186801|Clostridia,36ET7@31979|Clostridiaceae	186801|Clostridia	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
HKD2_k127_5919174_1	697281.Mahau_1484	6.858e-97	323.0	COG0726@1|root,COG0726@2|Bacteria,1UZGG@1239|Firmicutes,249C9@186801|Clostridia,42G3Z@68295|Thermoanaerobacterales	186801|Clostridia	G	PFAM Polysaccharide deacetylase	pdaB	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
HKD2_k127_5919174_0	1321778.HMPREF1982_00738	1.446e-166	533.0	COG2195@1|root,COG2195@2|Bacteria,1TP3A@1239|Firmicutes,248JJ@186801|Clostridia,2681C@186813|unclassified Clostridiales	186801|Clostridia	E	Cleaves the N-terminal amino acid of tripeptides	pepT	-	3.4.11.4	ko:K01258	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M42
HKD2_k127_5919174_2	1151292.QEW_2931	3.294e-83	278.0	COG3382@1|root,COG3382@2|Bacteria,1TT38@1239|Firmicutes,248VG@186801|Clostridia,25T3V@186804|Peptostreptococcaceae	186801|Clostridia	S	B3/4 domain	-	-	-	-	-	-	-	-	-	-	-	-	B3_4
HKD2_k127_601980_2	1123288.SOV_1c05640	4.19e-45	171.0	COG0840@1|root,COG0840@2|Bacteria,1TP5A@1239|Firmicutes,4H3VD@909932|Negativicutes	909932|Negativicutes	NT	SMART chemotaxis sensory transducer, histidine kinase HAMP region domain protein	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	4HB_MCP_1,HAMP,MCPsignal
HKD2_k127_601980_3	2325.TKV_c23420	2.975e-35	141.0	COG4492@1|root,COG4492@2|Bacteria,1VAJ9@1239|Firmicutes,24MTS@186801|Clostridia,42GC2@68295|Thermoanaerobacterales	186801|Clostridia	S	Belongs to the UPF0735 family	pheB	-	5.4.99.5	ko:K06209	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024,M00025	R01715	RC03116	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,ACT_4
HKD2_k127_601980_0	720554.Clocl_0596	3.218e-306	953.0	COG2183@1|root,COG2183@2|Bacteria,1TPFE@1239|Firmicutes,248P0@186801|Clostridia,3WGWI@541000|Ruminococcaceae	186801|Clostridia	K	Tex-like protein N-terminal domain	yhgF	-	-	ko:K06959	-	-	-	-	ko00000	-	-	-	HHH_3,S1,Tex_N,Tex_YqgF
HKD2_k127_601980_1	349161.Dred_2357	9.86e-93	338.0	COG5492@1|root,COG5492@2|Bacteria,1V17S@1239|Firmicutes,24GRG@186801|Clostridia	186801|Clostridia	N	S-layer domain-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,Big_5,Cadherin-like,SLH,Transglut_core
HKD2_k127_601980_4	871968.DESME_14160	1.377e-24	121.0	COG2247@1|root,COG3420@1|root,COG5632@1|root,COG2247@2|Bacteria,COG3420@2|Bacteria,COG5632@2|Bacteria,1VDZC@1239|Firmicutes,24A7N@186801|Clostridia,264FM@186807|Peptococcaceae	186801|Clostridia	M	Cell wall-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	CW_binding_2
HKD2_k127_6076229_4	1487921.DP68_02315	1.34e-36	140.0	COG0789@1|root,COG0789@2|Bacteria,1UKFM@1239|Firmicutes,25FVP@186801|Clostridia,36F0Y@31979|Clostridiaceae	186801|Clostridia	K	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_17
HKD2_k127_6076229_2	1121423.JONT01000005_gene2600	1.585e-47	173.0	2E49F@1|root,32Z57@2|Bacteria,1VA75@1239|Firmicutes,24NSI@186801|Clostridia,265BR@186807|Peptococcaceae	186801|Clostridia	S	Domain of unknown function (DUF4180)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4180
HKD2_k127_6076229_0	293826.Amet_4424	1.478e-157	501.0	COG0010@1|root,COG0010@2|Bacteria,1TR10@1239|Firmicutes,25D2D@186801|Clostridia,36DZW@31979|Clostridiaceae	186801|Clostridia	E	Belongs to the arginase family	rocF	-	3.5.3.1	ko:K01476	ko00220,ko00330,ko01100,ko01110,ko01130,ko01230,ko05146,map00220,map00330,map01100,map01110,map01130,map01230,map05146	M00029,M00134	R00551	RC00024,RC00329	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
HKD2_k127_6076229_5	398512.JQKC01000007_gene1047	5.873e-30	134.0	COG2931@1|root,COG4632@1|root,COG2931@2|Bacteria,COG4632@2|Bacteria	2|Bacteria	Q	calcium- and calmodulin-responsive adenylate cyclase activity	tagL	-	-	-	-	-	-	-	-	-	-	-	Calx-beta,Cu_amine_oxidN1,NAGPA,SLH
HKD2_k127_6076229_6	351627.Csac_0587	4.612e-27	122.0	2E720@1|root,331KM@2|Bacteria,1V6XB@1239|Firmicutes,24FI2@186801|Clostridia	186801|Clostridia	S	TraX protein	-	-	-	-	-	-	-	-	-	-	-	-	TraX
HKD2_k127_6076229_1	929506.CbC4_0082	4.66e-58	203.0	COG2824@1|root,COG2824@2|Bacteria,1V6NA@1239|Firmicutes,24J9K@186801|Clostridia,36K63@31979|Clostridiaceae	186801|Clostridia	P	Alkylphosphonate utilization operon protein PhnA	phnA	-	-	ko:K06193	ko01120,map01120	-	-	-	ko00000	-	-	-	PhnA,PhnA_Zn_Ribbon
HKD2_k127_6076229_3	646529.Desaci_2460	1.155e-42	159.0	COG1607@1|root,COG1607@2|Bacteria,1V3S2@1239|Firmicutes,24JIT@186801|Clostridia,265WG@186807|Peptococcaceae	186801|Clostridia	I	PFAM thioesterase superfamily	yciA	-	-	-	-	-	-	-	-	-	-	-	4HBT
HKD2_k127_6111066_0	756499.Desde_0595	7.569e-244	762.0	COG1053@1|root,COG1053@2|Bacteria,1TSI6@1239|Firmicutes,24EDZ@186801|Clostridia	1239|Firmicutes	C	Succinate dehydrogenase fumarate reductase flavoprotein subunit	-	-	1.3.5.4	ko:K00244	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020	M00009,M00011,M00150,M00173	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,FMN_bind
HKD2_k127_6111066_2	536227.CcarbDRAFT_1305	9.084e-99	342.0	COG2508@1|root,COG2508@2|Bacteria,1TRRH@1239|Firmicutes,24C6R@186801|Clostridia,36G3N@31979|Clostridiaceae	186801|Clostridia	QT	PucR C-terminal helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_30
HKD2_k127_6111066_1	469616.FMAG_00260	1.395e-122	405.0	COG0786@1|root,COG0786@2|Bacteria,3784D@32066|Fusobacteria	32066|Fusobacteria	P	Catalyzes the sodium-dependent transport of glutamate	-	-	-	ko:K03312	-	-	-	-	ko00000,ko02000	2.A.27	-	-	Glt_symporter
HKD2_k127_6111066_4	431943.CKL_2205	5.916e-45	166.0	COG1376@1|root,COG1376@2|Bacteria,1V9XU@1239|Firmicutes,24NW6@186801|Clostridia,36KPB@31979|Clostridiaceae	186801|Clostridia	M	ErfK YbiS YcfS YnhG family protein	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_1,YkuD
HKD2_k127_6111066_3	871968.DESME_03355	2.452e-69	249.0	COG1835@1|root,COG1835@2|Bacteria,1UHQ0@1239|Firmicutes,24XBH@186801|Clostridia,262ZB@186807|Peptococcaceae	186801|Clostridia	I	PFAM Acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
HKD2_k127_611340_0	1230342.CTM_01095	2.477e-73	256.0	COG0564@1|root,COG0564@2|Bacteria,1TS1T@1239|Firmicutes,249AH@186801|Clostridia,36EBK@31979|Clostridiaceae	186801|Clostridia	J	Responsible for synthesis of pseudouridine from uracil	rluA	-	5.4.99.23,5.4.99.28,5.4.99.29	ko:K06177,ko:K06180	-	-	-	-	ko00000,ko01000,ko03009,ko03016	-	-	-	PseudoU_synth_2
HKD2_k127_611340_5	580331.Thit_0450	3.351e-20	94.0	2E4QX@1|root,32ZJH@2|Bacteria,1VFAX@1239|Firmicutes,24S6V@186801|Clostridia,42GWG@68295|Thermoanaerobacterales	186801|Clostridia	S	Domain of unknown function (DUF4363)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4363
HKD2_k127_611340_1	203119.Cthe_3175	2.629e-68	239.0	COG2323@1|root,COG2323@2|Bacteria,1V3NW@1239|Firmicutes,24H1Q@186801|Clostridia,3WJ0A@541000|Ruminococcaceae	186801|Clostridia	S	Protein of unknown function (DUF421)	-	-	-	-	-	-	-	-	-	-	-	-	DUF421
HKD2_k127_611340_3	1304284.L21TH_0346	6.574e-39	149.0	COG2905@1|root,COG2905@2|Bacteria,1VW3X@1239|Firmicutes,24MYP@186801|Clostridia,36IUV@31979|Clostridiaceae	186801|Clostridia	T	CBS domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS
HKD2_k127_611340_2	536227.CcarbDRAFT_1582	2.93e-59	211.0	COG1595@1|root,COG1595@2|Bacteria,1TS3M@1239|Firmicutes,24IW2@186801|Clostridia,36VT5@31979|Clostridiaceae	186801|Clostridia	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD2_k127_611340_6	720554.Clocl_1753	6.889e-13	74.0	2C40W@1|root,334PI@2|Bacteria,1VB3H@1239|Firmicutes,24NG2@186801|Clostridia,3WJU4@541000|Ruminococcaceae	186801|Clostridia	S	Putative zinc-finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
HKD2_k127_611340_4	536227.CcarbDRAFT_1580	5.878e-26	116.0	2E841@1|root,332HT@2|Bacteria,1VJ56@1239|Firmicutes,24SDM@186801|Clostridia,36N2G@31979|Clostridiaceae	186801|Clostridia	S	Protein of unknown function (DUF2953)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2953
HKD2_k127_6300094_4	768706.Desor_3984	4.889e-46	168.0	COG1149@1|root,COG1149@2|Bacteria,1V4I0@1239|Firmicutes,24HMG@186801|Clostridia,26299@186807|Peptococcaceae	186801|Clostridia	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
HKD2_k127_6300094_1	1408422.JHYF01000001_gene3065	5.398e-152	487.0	COG0446@1|root,COG0446@2|Bacteria,1TQH5@1239|Firmicutes,247YR@186801|Clostridia,36G6B@31979|Clostridiaceae	186801|Clostridia	C	FAD dependent oxidoreductase	-	-	1.5.3.1	ko:K00302	ko00260,ko01100,map00260,map01100	-	R00610	RC00060,RC00557	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_3
HKD2_k127_6300094_3	1121422.AUMW01000026_gene383	7.222e-48	173.0	COG3383@1|root,COG3383@2|Bacteria,1VAVK@1239|Firmicutes,24MYJ@186801|Clostridia,265MS@186807|Peptococcaceae	186801|Clostridia	C	2Fe-2S iron-sulfur cluster binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer2_4
HKD2_k127_6300094_0	994573.T472_0218960	1.061e-245	767.0	COG0591@1|root,COG0591@2|Bacteria,1TPVE@1239|Firmicutes,248NQ@186801|Clostridia,36FNJ@31979|Clostridiaceae	186801|Clostridia	E	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	putP	-	-	ko:K03307,ko:K11928	-	-	-	-	ko00000,ko02000	2.A.21,2.A.21.2	-	-	SSF
HKD2_k127_6300094_2	1347392.CCEZ01000043_gene98	7.573e-118	381.0	COG0442@1|root,COG0442@2|Bacteria,1TRBV@1239|Firmicutes,249PY@186801|Clostridia,36DVT@31979|Clostridiaceae	186801|Clostridia	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS	proS	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,ProRS-C_1,tRNA-synt_2b,tRNA_edit
HKD2_k127_6319793_4	1122918.KB907245_gene5181	2.363e-30	123.0	COG0500@1|root,COG2226@2|Bacteria,1TSAZ@1239|Firmicutes,4HFFF@91061|Bacilli,26WG4@186822|Paenibacillaceae	91061|Bacilli	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
HKD2_k127_6319793_2	865861.AZSU01000002_gene3152	9.297e-36	144.0	2EFIV@1|root,339B9@2|Bacteria,1VIU3@1239|Firmicutes,24RWF@186801|Clostridia,36MVZ@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6319793_0	1211817.CCAT010000045_gene3059	2.008e-83	287.0	2DVYG@1|root,33XQ1@2|Bacteria,1VW8T@1239|Firmicutes,24AK8@186801|Clostridia,36HWT@31979|Clostridiaceae	186801|Clostridia	S	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_10
HKD2_k127_6319793_3	358681.BBR47_07270	7.607e-33	135.0	COG3755@1|root,COG3755@2|Bacteria,1VU0X@1239|Firmicutes,4HTXN@91061|Bacilli,26SB3@186822|Paenibacillaceae	91061|Bacilli	S	Lysozyme inhibitor LprI	-	-	-	-	-	-	-	-	-	-	-	-	LprI
HKD2_k127_6319793_1	350688.Clos_0110	2.547e-46	168.0	COG1670@1|root,COG1670@2|Bacteria,1V40U@1239|Firmicutes,24JVI@186801|Clostridia,36IBY@31979|Clostridiaceae	186801|Clostridia	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
HKD2_k127_6346191_17	1321778.HMPREF1982_00474	4.419e-32	127.0	2EEIV@1|root,338CT@2|Bacteria,1VHW1@1239|Firmicutes,24TGU@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6346191_2	536227.CcarbDRAFT_0831	1.344e-240	755.0	COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247T8@186801|Clostridia,36EMB@31979|Clostridiaceae	186801|Clostridia	V	ABC transporter	yfiB	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
HKD2_k127_6346191_0	1321778.HMPREF1982_01290	2.26e-265	829.0	COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247Q0@186801|Clostridia,26AWU@186813|unclassified Clostridiales	186801|Clostridia	V	ABC transporter transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
HKD2_k127_6346191_1	1195236.CTER_0226	1.341e-245	765.0	COG1488@1|root,COG1488@2|Bacteria,1TPDW@1239|Firmicutes,247NY@186801|Clostridia,3WGKF@541000|Ruminococcaceae	186801|Clostridia	H	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP	pncB	-	6.3.4.21	ko:K00763	ko00760,ko01100,map00760,map01100	-	R01724	RC00033	ko00000,ko00001,ko01000	-	-	-	NAPRTase,QRPTase_C,QRPTase_N
HKD2_k127_6346191_8	1294142.CINTURNW_0838	1.662e-144	462.0	COG0037@1|root,COG0037@2|Bacteria,1TQ0Y@1239|Firmicutes,247RP@186801|Clostridia,36DIN@31979|Clostridiaceae	186801|Clostridia	H	Belongs to the TtcA family	ttcA	-	-	-	-	-	-	-	-	-	-	-	ATP_bind_3,Rhodanese
HKD2_k127_6346191_9	293826.Amet_2819	3.65e-91	309.0	COG0457@1|root,COG0457@2|Bacteria,1V4UY@1239|Firmicutes,25B4A@186801|Clostridia,36W90@31979|Clostridiaceae	186801|Clostridia	S	Tetratricopeptide TPR_2 repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_2,TPR_7,TPR_8
HKD2_k127_6346191_5	1033810.HLPCO_001959	2.318e-173	553.0	COG1055@1|root,COG1055@2|Bacteria,2NPE3@2323|unclassified Bacteria	2|Bacteria	P	Arsenical pump membrane protein	arsA	-	-	ko:K03893	-	-	-	-	ko00000,ko02000	2.A.45.1,3.A.4.1	-	-	CitMHS
HKD2_k127_6346191_13	1033810.HLPCO_001960	9.765e-50	181.0	2C1XY@1|root,32SVI@2|Bacteria	2|Bacteria	S	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6346191_10	509191.AEDB02000073_gene1926	2.996e-83	280.0	COG1388@1|root,COG2340@1|root,COG1388@2|Bacteria,COG2340@2|Bacteria,1V6GZ@1239|Firmicutes,24BAQ@186801|Clostridia,3WJQ5@541000|Ruminococcaceae	186801|Clostridia	M	Cysteine-rich secretory protein family	safA	-	-	-	-	-	-	-	-	-	-	-	CAP,LysM
HKD2_k127_6346191_4	1487921.DP68_10935	7.52e-178	578.0	COG0840@1|root,COG0840@2|Bacteria,1TP5A@1239|Firmicutes,247S3@186801|Clostridia,36EVU@31979|Clostridiaceae	186801|Clostridia	NT	histidine kinase HAMP region domain protein	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	HAMP,MCPsignal,dCache_1,sCache_2
HKD2_k127_6346191_3	941824.TCEL_02267	1.403e-187	590.0	COG0205@1|root,COG0205@2|Bacteria,1TPF4@1239|Firmicutes,249AM@186801|Clostridia,36DN7@31979|Clostridiaceae	186801|Clostridia	F	Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis	pfkA2	-	2.7.1.11,2.7.1.90	ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
HKD2_k127_6346191_11	1414720.CBYM010000044_gene1526	4.182e-80	270.0	COG0652@1|root,COG0652@2|Bacteria,1TRHW@1239|Firmicutes,247XN@186801|Clostridia,36HY3@31979|Clostridiaceae	186801|Clostridia	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	rotA	-	5.2.1.8	ko:K03768	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Pro_isomerase
HKD2_k127_6346191_14	398512.JQKC01000008_gene949	3.985e-39	153.0	COG0526@1|root,COG0526@2|Bacteria,1VAPY@1239|Firmicutes,25B5Z@186801|Clostridia,3WKSE@541000|Ruminococcaceae	186801|Clostridia	CO	Thioredoxin-like	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,Redoxin
HKD2_k127_6346191_12	290402.Cbei_2976	6.303e-80	273.0	COG0785@1|root,COG0785@2|Bacteria,1TQH1@1239|Firmicutes,249IS@186801|Clostridia,36FFI@31979|Clostridiaceae	186801|Clostridia	O	Cytochrome c biogenesis protein transmembrane region	ccdA	-	-	ko:K06196	-	-	-	-	ko00000,ko02000	5.A.1.2	-	-	AhpC-TSA,DsbD,Redoxin
HKD2_k127_6346191_6	373903.Hore_08970	3.069e-148	475.0	COG0180@1|root,COG0180@2|Bacteria,1TPY7@1239|Firmicutes,248RC@186801|Clostridia,3WADX@53433|Halanaerobiales	186801|Clostridia	J	PFAM tRNA synthetases class I (W and Y)	trpS	-	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
HKD2_k127_6346191_18	1121289.JHVL01000013_gene1681	3.456e-27	118.0	2BAHE@1|root,323Y0@2|Bacteria,1V9HC@1239|Firmicutes,24JZ9@186801|Clostridia,36JMJ@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6346191_15	445973.CLOBAR_02559	2.552e-35	139.0	COG0736@1|root,COG0736@2|Bacteria,1VA0T@1239|Firmicutes,24RC0@186801|Clostridia,25RK6@186804|Peptostreptococcaceae	186801|Clostridia	I	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein	acpS	-	2.7.8.7	ko:K00997	ko00770,map00770	-	R01625	RC00002	ko00000,ko00001,ko01000	-	-	iHN637.CLJU_RS01470	ACPS
HKD2_k127_6346191_16	1304284.L21TH_2443	2.341e-33	136.0	COG2834@1|root,COG2834@2|Bacteria,1VQK5@1239|Firmicutes,24NV8@186801|Clostridia,36KYV@31979|Clostridiaceae	186801|Clostridia	M	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)	-	-	-	-	-	-	-	-	-	-	-	-	LolA
HKD2_k127_6346191_7	865861.AZSU01000001_gene166	3.891e-147	475.0	COG0787@1|root,COG0787@2|Bacteria,1TNYY@1239|Firmicutes,2480T@186801|Clostridia,36ES8@31979|Clostridiaceae	186801|Clostridia	M	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids	alr	-	5.1.1.1	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	-	R00401	RC00285	ko00000,ko00001,ko01000,ko01011	-	-	iHN637.CLJU_RS15830	Ala_racemase_C,Ala_racemase_N
HKD2_k127_6346191_19	1121289.JHVL01000013_gene1676	1.814e-25	108.0	COG0864@1|root,COG0864@2|Bacteria,1VA28@1239|Firmicutes,24QKP@186801|Clostridia	186801|Clostridia	K	Transcriptional regulator, CopG family	-	-	-	ko:K07723	-	-	-	-	ko00000,ko02048,ko03000	-	-	-	RHH_1
HKD2_k127_6386584_1	1128398.Curi_c01660	5.103e-121	432.0	COG4733@1|root,COG4733@2|Bacteria,1TT7S@1239|Firmicutes,24EIJ@186801|Clostridia	186801|Clostridia	S	Cell surface receptor IPT TIG	-	-	-	-	-	-	-	-	-	-	-	-	TIG,fn3
HKD2_k127_6386584_4	1121289.JHVL01000001_gene1883	1.005e-23	119.0	2E09F@1|root,32VX2@2|Bacteria,1UJNA@1239|Firmicutes,25F6D@186801|Clostridia	186801|Clostridia	S	S-layer homology domain	-	-	-	-	-	-	-	-	-	-	-	-	SLH
HKD2_k127_6386584_3	509191.AEDB02000022_gene2951	3.12e-80	286.0	COG4632@1|root,COG4632@2|Bacteria,1UKSW@1239|Firmicutes,25G2R@186801|Clostridia,3WSSE@541000|Ruminococcaceae	186801|Clostridia	G	S-layer homology domain	-	-	-	-	-	-	-	-	-	-	-	-	SLH
HKD2_k127_6386584_2	1304284.L21TH_0141	1.727e-113	381.0	COG0793@1|root,COG0793@2|Bacteria,1TPBI@1239|Firmicutes,248HZ@186801|Clostridia,36DR5@31979|Clostridiaceae	186801|Clostridia	M	Belongs to the peptidase S41A family	-	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ_2,PG_binding_1,Peptidase_S41
HKD2_k127_6386584_0	1408422.JHYF01000012_gene3181	3.117e-272	844.0	COG0504@1|root,COG0504@2|Bacteria,1TP34@1239|Firmicutes,2482E@186801|Clostridia,36DBK@31979|Clostridiaceae	186801|Clostridia	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS01075	CTP_synth_N,GATase
HKD2_k127_6386584_5	572479.Hprae_2099	7.97e-11	71.0	COG0457@1|root,COG0457@2|Bacteria,1UVB5@1239|Firmicutes,25I15@186801|Clostridia,3WBX2@53433|Halanaerobiales	186801|Clostridia	S	PFAM Tetratricopeptide TPR_1 repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_2,TPR_8
HKD2_k127_6393906_3	1304284.L21TH_2011	3.282e-121	399.0	COG1215@1|root,COG4641@1|root,COG1215@2|Bacteria,COG4641@2|Bacteria,1TQDC@1239|Firmicutes,24C5S@186801|Clostridia,36F27@31979|Clostridiaceae	186801|Clostridia	M	DUF based on E. rectale Gene description (DUF3880)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3880,Glyco_trans_1_2,Glycos_transf_2
HKD2_k127_6393906_11	1280663.ATVR01000003_gene156	2.257e-37	148.0	COG2120@1|root,COG2120@2|Bacteria	2|Bacteria	S	N-acetylglucosaminylinositol deacetylase activity	yaiS	-	-	-	-	-	-	-	-	-	-	-	PIG-L
HKD2_k127_6393906_8	484770.UFO1_4096	3.886e-74	256.0	COG0224@1|root,COG0224@2|Bacteria,1UZIQ@1239|Firmicutes,4H5ZQ@909932|Negativicutes	909932|Negativicutes	C	WbqC-like protein family	-	-	-	-	-	-	-	-	-	-	-	-	WbqC
HKD2_k127_6393906_0	350688.Clos_2304	4.686e-181	573.0	COG0436@1|root,COG0436@2|Bacteria,1TP0J@1239|Firmicutes,247NQ@186801|Clostridia,36DUZ@31979|Clostridiaceae	186801|Clostridia	E	Aminotransferase	aspC	-	2.6.1.1	ko:K00812,ko:K10907	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
HKD2_k127_6393906_4	1286171.EAL2_c17440	6.048e-120	389.0	COG1126@1|root,COG1126@2|Bacteria,1TNYD@1239|Firmicutes,247QZ@186801|Clostridia,25VT5@186806|Eubacteriaceae	186801|Clostridia	E	Psort location CytoplasmicMembrane, score	glnQ	-	3.6.3.21	ko:K02028,ko:K10041	ko02010,map02010	M00228,M00236	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.3	-	-	ABC_tran
HKD2_k127_6393906_7	1293054.HSACCH_00938	3.599e-85	287.0	COG0765@1|root,COG0765@2|Bacteria,1TPM3@1239|Firmicutes,248UY@186801|Clostridia,3WBEH@53433|Halanaerobiales	186801|Clostridia	E	TIGRFAM amine acid ABC transporter, permease protein, 3-TM region, His Glu Gln Arg opine family	-	-	-	ko:K02029,ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	BPD_transp_1
HKD2_k127_6393906_6	1304284.L21TH_0554	1.9e-96	322.0	COG0834@1|root,COG0834@2|Bacteria,1TT16@1239|Firmicutes,24CEZ@186801|Clostridia,36EZP@31979|Clostridiaceae	186801|Clostridia	ET	Belongs to the bacterial solute-binding protein 3 family	artP	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	SBP_bac_3
HKD2_k127_6393906_1	1121289.JHVL01000012_gene1688	9.894e-168	537.0	COG3875@1|root,COG3875@2|Bacteria,1TQ1C@1239|Firmicutes,247PH@186801|Clostridia,36DMW@31979|Clostridiaceae	186801|Clostridia	S	Domain of unknown function (DUF2088)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2088
HKD2_k127_6393906_12	97138.C820_02713	1.998e-34	152.0	COG0265@1|root,COG0265@2|Bacteria,1UZ8K@1239|Firmicutes,24N2F@186801|Clostridia,36NDF@31979|Clostridiaceae	186801|Clostridia	O	Trypsin	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	Cu_amine_oxidN1,DUF5050,RsgI_N,Trypsin_2
HKD2_k127_6393906_10	1121335.Clst_0437	3.653e-39	167.0	COG0265@1|root,COG0265@2|Bacteria,1UY9N@1239|Firmicutes,24E52@186801|Clostridia	186801|Clostridia	O	Belongs to the glycosyl hydrolase 43 family	-	-	-	-	-	-	-	-	-	-	-	-	SLH
HKD2_k127_6393906_9	1265503.KB905169_gene190	6.446e-51	198.0	COG2211@1|root,COG2211@2|Bacteria,1MVUM@1224|Proteobacteria,1RP5J@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	COG2211 Na melibiose symporter and related transporters	-	-	-	ko:K03292	-	-	-	-	ko00000	2.A.2	-	-	MFS_2
HKD2_k127_6393906_2	1403313.AXBR01000010_gene1057	1.873e-127	420.0	COG0477@1|root,COG0477@2|Bacteria,1UHRM@1239|Firmicutes,4ISTP@91061|Bacilli,1ZSG1@1386|Bacillus	91061|Bacilli	EGP	Transmembrane secretion effector	-	-	-	ko:K08217	-	-	-	-	br01600,ko00000,ko01504,ko02000	2.A.1.21.1,2.A.1.21.22	-	-	MFS_1
HKD2_k127_6393906_5	1121936.AUHI01000001_gene971	1.091e-102	346.0	COG0457@1|root,COG2199@1|root,COG0457@2|Bacteria,COG3706@2|Bacteria,1TQIK@1239|Firmicutes,4HBMB@91061|Bacilli	91061|Bacilli	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE3,GGDEF
HKD2_k127_6398579_5	318464.IO99_17185	9.743e-97	318.0	COG1592@1|root,COG1592@2|Bacteria,1TSUY@1239|Firmicutes,248GY@186801|Clostridia,36EFS@31979|Clostridiaceae	186801|Clostridia	C	Rubrerythrin	rbr3A	GO:0000302,GO:0003674,GO:0003824,GO:0004601,GO:0005488,GO:0005506,GO:0006091,GO:0006950,GO:0006970,GO:0006979,GO:0008150,GO:0008152,GO:0009055,GO:0009056,GO:0009266,GO:0009268,GO:0009408,GO:0009409,GO:0009628,GO:0009636,GO:0009651,GO:0009987,GO:0010035,GO:0010446,GO:0016209,GO:0016491,GO:0016684,GO:0016692,GO:0016999,GO:0017001,GO:0017144,GO:0022900,GO:0033554,GO:0034599,GO:0034605,GO:0034614,GO:0035690,GO:0042221,GO:0042493,GO:0042542,GO:0042737,GO:0042743,GO:0042744,GO:0043167,GO:0043169,GO:0044237,GO:0044248,GO:0046677,GO:0046872,GO:0046914,GO:0050896,GO:0051186,GO:0051187,GO:0051716,GO:0055114,GO:0070301,GO:0070417,GO:0070482,GO:0070887,GO:0071214,GO:0071236,GO:0071453,GO:0071467,GO:0071469,GO:0071470,GO:0071472,GO:0072593,GO:0097237,GO:0098754,GO:0098869,GO:0104004,GO:1901700,GO:1901701,GO:1990748	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
HKD2_k127_6398579_7	720554.Clocl_0586	1.128e-70	257.0	COG3409@1|root,COG3409@2|Bacteria,1V262@1239|Firmicutes,24H4C@186801|Clostridia,3WIH4@541000|Ruminococcaceae	186801|Clostridia	M	Putative peptidoglycan binding domain	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_1
HKD2_k127_6398579_12	1297617.JPJD01000076_gene1095	2.375e-14	86.0	COG3409@1|root,COG3773@1|root,COG3409@2|Bacteria,COG3773@2|Bacteria,1TRFW@1239|Firmicutes,24912@186801|Clostridia,267IR@186813|unclassified Clostridiales	186801|Clostridia	M	Cell Wall Hydrolase	sleB	-	3.5.1.28	ko:K01449	-	-	R04112	RC00064,RC00141	ko00000,ko01000	-	-	-	Hydrolase_2,PG_binding_1
HKD2_k127_6398579_1	1449126.JQKL01000002_gene1544	2.436e-192	620.0	COG0840@1|root,COG0840@2|Bacteria,1TP5A@1239|Firmicutes,247S3@186801|Clostridia,26A5N@186813|unclassified Clostridiales	186801|Clostridia	NT	Cache domain	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	HAMP,MCPsignal,dCache_1
HKD2_k127_6398579_2	720554.Clocl_2985	5.019e-151	491.0	COG2078@1|root,COG3885@1|root,COG2078@2|Bacteria,COG3885@2|Bacteria,1TQH8@1239|Firmicutes,2491Q@186801|Clostridia,3WHBY@541000|Ruminococcaceae	186801|Clostridia	S	AMMECR1	-	-	-	ko:K06990,ko:K09141	-	-	-	-	ko00000,ko04812	-	-	-	AMMECR1,LigB
HKD2_k127_6398579_3	935948.KE386495_gene2007	1.11e-131	427.0	COG1180@1|root,COG1180@2|Bacteria,1TP46@1239|Firmicutes,248K9@186801|Clostridia,42F1Z@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM Radical SAM domain protein	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
HKD2_k127_6398579_11	635013.TherJR_2376	1.513e-33	140.0	COG5521@1|root,COG5521@2|Bacteria,1V2MC@1239|Firmicutes,24EG2@186801|Clostridia	186801|Clostridia	S	Protein of unknown function (DUF1189)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1189
HKD2_k127_6398579_10	555088.DealDRAFT_0314	9.925e-47	173.0	COG0622@1|root,COG0622@2|Bacteria,1VA0U@1239|Firmicutes,24MMK@186801|Clostridia,42K6X@68298|Syntrophomonadaceae	186801|Clostridia	S	Calcineurin-like phosphoesterase superfamily domain	yfcE1	-	-	ko:K07095	-	-	-	-	ko00000	-	-	-	Metallophos_2
HKD2_k127_6398579_9	1286171.EAL2_c04360	1.345e-53	194.0	COG0746@1|root,COG0746@2|Bacteria,1VA6T@1239|Firmicutes,24JG6@186801|Clostridia,25XR2@186806|Eubacteriaceae	186801|Clostridia	H	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor	mobA	-	2.7.7.77	ko:K03752,ko:K13818	ko00790,ko01100,map00790,map01100	-	R11581	-	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
HKD2_k127_6398579_6	1408422.JHYF01000008_gene3778	6.761e-82	278.0	COG4662@1|root,COG4662@2|Bacteria,1TRK7@1239|Firmicutes,249VG@186801|Clostridia,36IMF@31979|Clostridiaceae	186801|Clostridia	P	inner membrane component	tupB	-	-	ko:K05773	ko02010,map02010	M00186	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.2,3.A.1.6.4	-	-	BPD_transp_1
HKD2_k127_6398579_8	1391646.AVSU01000100_gene3387	1.261e-62	222.0	COG3839@1|root,COG3839@2|Bacteria,1UXE2@1239|Firmicutes,25KBW@186801|Clostridia,25T70@186804|Peptostreptococcaceae	186801|Clostridia	G	ATPases associated with a variety of cellular activities	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
HKD2_k127_6398579_4	1391646.AVSU01000100_gene3386	2.816e-121	402.0	COG0303@1|root,COG0303@2|Bacteria,1TQJ8@1239|Firmicutes,248WP@186801|Clostridia,25SJQ@186804|Peptostreptococcaceae	186801|Clostridia	H	MoeA C-terminal region (domain IV)	moeA	-	2.10.1.1	ko:K03750	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N
HKD2_k127_6398579_0	903814.ELI_1429	5.353e-217	688.0	COG0303@1|root,COG1910@1|root,COG0303@2|Bacteria,COG1910@2|Bacteria,1TRH3@1239|Firmicutes,24ATZ@186801|Clostridia,25X20@186806|Eubacteriaceae	186801|Clostridia	HP	MoeA N-terminal region (domain I and II)	-	-	2.10.1.1	ko:K03750,ko:K07219	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N,PBP_like
HKD2_k127_6419068_4	203119.Cthe_0898	2.358e-82	286.0	COG2206@1|root,COG2206@2|Bacteria,1TR95@1239|Firmicutes,25AZS@186801|Clostridia,3WNWT@541000|Ruminococcaceae	186801|Clostridia	T	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	HD
HKD2_k127_6419068_6	1120746.CCNL01000014_gene2065	2.269e-68	243.0	COG0598@1|root,COG0598@2|Bacteria	2|Bacteria	P	Magnesium transport protein CorA	corA	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
HKD2_k127_6419068_1	941824.TCEL_02140	6.112e-160	515.0	COG1092@1|root,COG1092@2|Bacteria,1TRAJ@1239|Firmicutes,247TI@186801|Clostridia,36F5Z@31979|Clostridiaceae	186801|Clostridia	J	S-adenosylmethionine-dependent methyltransferase	rlmI	-	2.1.1.191	ko:K06969	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_SAM,PUA
HKD2_k127_6419068_0	1321778.HMPREF1982_02621	5.769e-174	574.0	COG5426@1|root,COG5426@2|Bacteria,1UJJE@1239|Firmicutes,25F4H@186801|Clostridia	186801|Clostridia	S	von Willebrand factor, type A	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6419068_3	1195236.CTER_1812	1.269e-125	409.0	COG1131@1|root,COG1131@2|Bacteria,1TQUS@1239|Firmicutes,25AZ1@186801|Clostridia,3WH5S@541000|Ruminococcaceae	186801|Clostridia	V	ABC-type multidrug transport system ATPase component	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
HKD2_k127_6419068_5	1321778.HMPREF1982_02619	2.661e-78	271.0	COG1668@1|root,COG1668@2|Bacteria,1UIA3@1239|Firmicutes,25EF1@186801|Clostridia	186801|Clostridia	CP	ABC-2 family transporter protein	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane_2,ABC2_membrane_3
HKD2_k127_6419068_7	1540257.JQMW01000013_gene1237	3.938e-67	248.0	COG1196@1|root,COG3064@1|root,COG1196@2|Bacteria,COG3064@2|Bacteria,1V11A@1239|Firmicutes,25EF2@186801|Clostridia,36UNM@31979|Clostridiaceae	186801|Clostridia	D	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6419068_2	1321778.HMPREF1982_02617	1.297e-157	502.0	COG0714@1|root,COG0714@2|Bacteria,1TPKR@1239|Firmicutes,248IM@186801|Clostridia,268KE@186813|unclassified Clostridiales	186801|Clostridia	S	Psort location Cytoplasmic, score 9.97	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
HKD2_k127_6419068_8	1195236.CTER_1808	1.147e-42	158.0	COG1721@1|root,COG1721@2|Bacteria,1V2UW@1239|Firmicutes,24AGA@186801|Clostridia	186801|Clostridia	S	protein some members contain a von Willebrand factor type A	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
HKD2_k127_6441867_8	293826.Amet_0496	2.829e-33	135.0	COG2866@1|root,COG2866@2|Bacteria	2|Bacteria	E	metallocarboxypeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,Big_4,Cadherin-like,Lactonase,SLH,fn3
HKD2_k127_6441867_10	1408422.JHYF01000011_gene3433	1.09e-11	76.0	2F4T9@1|root,33XFT@2|Bacteria,1VW6U@1239|Firmicutes,251EP@186801|Clostridia,36RZ2@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6441867_4	138119.DSY0802	2.756e-70	241.0	COG2210@1|root,COG2210@2|Bacteria,1V2KC@1239|Firmicutes,24GHS@186801|Clostridia,261T4@186807|Peptococcaceae	186801|Clostridia	S	DsrE/DsrF/DrsH-like family	-	-	-	-	-	-	-	-	-	-	-	-	DrsE_2
HKD2_k127_6441867_1	1321778.HMPREF1982_03017	5.642e-183	583.0	COG0520@1|root,COG0520@2|Bacteria,1TQ1W@1239|Firmicutes,249CS@186801|Clostridia,26AQ4@186813|unclassified Clostridiales	186801|Clostridia	E	Beta-eliminating lyase	csd	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
HKD2_k127_6441867_5	340099.Teth39_0886	1.755e-61	226.0	COG2843@1|root,COG2843@2|Bacteria,1UZW4@1239|Firmicutes,24950@186801|Clostridia,42HBQ@68295|Thermoanaerobacterales	186801|Clostridia	M	PFAM Capsule synthesis protein, CapA	-	-	-	ko:K07282	-	-	-	-	ko00000	-	-	-	PGA_cap
HKD2_k127_6441867_7	913865.DOT_4596	6.018e-41	156.0	COG1451@1|root,COG1451@2|Bacteria,1V6WP@1239|Firmicutes,24JGH@186801|Clostridia,2626V@186807|Peptococcaceae	186801|Clostridia	S	Metal-dependent hydrolase	-	-	-	ko:K07043	-	-	-	-	ko00000	-	-	-	DUF45
HKD2_k127_6441867_9	1487921.DP68_12025	2.752e-31	133.0	COG4939@1|root,COG4939@2|Bacteria,1TSWI@1239|Firmicutes,25CKQ@186801|Clostridia,36WXT@31979|Clostridiaceae	186801|Clostridia	S	FMN_bind	-	-	-	-	-	-	-	-	-	-	-	-	FMN_bind
HKD2_k127_6441867_0	273068.TTE2486	4.8e-211	671.0	COG1252@1|root,COG1252@2|Bacteria,1TR6X@1239|Firmicutes,249J5@186801|Clostridia,42FI1@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	1.6.99.3	ko:K03885	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	DoxD,DoxX,Pyr_redox_2
HKD2_k127_6441867_6	1304284.L21TH_1504	3.786e-59	206.0	COG0853@1|root,COG0853@2|Bacteria,1V6NQ@1239|Firmicutes,24JVN@186801|Clostridia,36K0M@31979|Clostridiaceae	186801|Clostridia	H	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine	panD	-	4.1.1.11	ko:K01579	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R00489	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Asp_decarbox
HKD2_k127_6441867_3	398512.JQKC01000020_gene4044	2.469e-111	366.0	COG0414@1|root,COG0414@2|Bacteria,1TP7A@1239|Firmicutes,248AN@186801|Clostridia,3WHX6@541000|Ruminococcaceae	186801|Clostridia	H	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate	panC	-	6.3.2.1	ko:K01918	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R02473	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_ligase
HKD2_k127_6441867_2	1304284.L21TH_1506	7.788e-129	415.0	COG0413@1|root,COG0413@2|Bacteria,1TPZA@1239|Firmicutes,248RR@186801|Clostridia,36EKX@31979|Clostridiaceae	186801|Clostridia	H	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate	panB	-	2.1.2.11	ko:K00606	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R01226	RC00022,RC00200	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_transf
HKD2_k127_6442997_3	720554.Clocl_2982	3.439e-07	52.0	COG4856@1|root,COG4856@2|Bacteria,1TSIV@1239|Firmicutes,24GKC@186801|Clostridia,3WJKV@541000|Ruminococcaceae	186801|Clostridia	S	YbbR-like protein	-	-	-	-	-	-	-	-	-	-	-	-	YbbR
HKD2_k127_6442997_1	697303.Thewi_2191	5.796e-95	318.0	COG1624@1|root,COG1624@2|Bacteria,1TPRW@1239|Firmicutes,249K8@186801|Clostridia,42FDQ@68295|Thermoanaerobacterales	186801|Clostridia	S	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria	dacA	-	2.7.7.85	ko:K18672	-	-	-	-	ko00000,ko01000	-	-	-	DisA_N
HKD2_k127_6442997_2	635013.TherJR_1405	2.125e-87	295.0	COG1968@1|root,COG1968@2|Bacteria,1TPFA@1239|Firmicutes,249KK@186801|Clostridia,260XY@186807|Peptococcaceae	186801|Clostridia	V	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin	uppP	-	3.6.1.27	ko:K06153	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	BacA
HKD2_k127_6442997_0	1304880.JAGB01000002_gene2278	1.818e-119	400.0	COG0534@1|root,COG0534@2|Bacteria,1TNZN@1239|Firmicutes,247YX@186801|Clostridia	186801|Clostridia	V	Mate efflux family protein	mepA_10	-	-	-	-	-	-	-	-	-	-	-	MatE
HKD2_k127_6444486_5	1487921.DP68_10750	7.27e-60	213.0	COG0426@1|root,COG0426@2|Bacteria,1VRFW@1239|Firmicutes,24BWR@186801|Clostridia,36GPG@31979|Clostridiaceae	186801|Clostridia	C	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6444486_2	1487921.DP68_18065	9.779e-175	559.0	COG0569@1|root,COG0569@2|Bacteria,1TPNS@1239|Firmicutes,24830@186801|Clostridia,36ERV@31979|Clostridiaceae	186801|Clostridia	P	domain protein	trkA	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
HKD2_k127_6444486_1	1487921.DP68_18060	1.476e-189	603.0	COG0168@1|root,COG0168@2|Bacteria,1TPAF@1239|Firmicutes,248K4@186801|Clostridia,36E52@31979|Clostridiaceae	186801|Clostridia	P	potassium uptake protein TrkH	trkH	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
HKD2_k127_6444486_3	1304284.L21TH_0716	1.18e-130	433.0	COG0534@1|root,COG0534@2|Bacteria,1TQ56@1239|Firmicutes,248YU@186801|Clostridia,36DVM@31979|Clostridiaceae	186801|Clostridia	V	MATE efflux family protein	-	-	-	-	-	-	-	-	-	-	-	-	MatE
HKD2_k127_6444486_0	1321778.HMPREF1982_01278	3.178e-293	905.0	COG0488@1|root,COG0488@2|Bacteria,1TPW0@1239|Firmicutes,248ST@186801|Clostridia,267PH@186813|unclassified Clostridiales	186801|Clostridia	S	ABC transporter	yheS_1	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,ABC_tran_Xtn
HKD2_k127_6444486_6	1268072.PSAB_23110	1.563e-26	115.0	COG4939@1|root,COG4939@2|Bacteria,1TSWI@1239|Firmicutes,4IR0S@91061|Bacilli,26TG6@186822|Paenibacillaceae	91061|Bacilli	S	FMN_bind	-	-	-	-	-	-	-	-	-	-	-	-	FMN_bind
HKD2_k127_6444486_4	635013.TherJR_2669	3.506e-119	388.0	COG0683@1|root,COG0683@2|Bacteria,1TPQ2@1239|Firmicutes,248H1@186801|Clostridia,260KX@186807|Peptococcaceae	186801|Clostridia	E	PFAM Extracellular ligand-binding receptor	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
HKD2_k127_6475211_5	1408823.AXUS01000006_gene17	1.487e-42	169.0	COG0826@1|root,COG0826@2|Bacteria,1TQS1@1239|Firmicutes,24909@186801|Clostridia,25QXR@186804|Peptostreptococcaceae	186801|Clostridia	O	Peptidase, U32 family	ydcP	-	-	ko:K08303	ko05120,map05120	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	DUF3656,Peptidase_U32
HKD2_k127_6475211_1	1304284.L21TH_0823	8.773e-84	283.0	COG0745@1|root,COG0745@2|Bacteria,1TPZ0@1239|Firmicutes,2484X@186801|Clostridia,36I3S@31979|Clostridiaceae	186801|Clostridia	K	Transcriptional regulatory protein, C terminal	srrA	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
HKD2_k127_6475211_3	1304284.L21TH_0824	1.735e-70	257.0	COG0642@1|root,COG2205@2|Bacteria,1V10X@1239|Firmicutes,24P7E@186801|Clostridia,36UII@31979|Clostridiaceae	186801|Clostridia	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
HKD2_k127_6475211_0	1304284.L21TH_1036	1.244e-273	862.0	COG1193@1|root,COG1193@2|Bacteria,1TP5W@1239|Firmicutes,248YK@186801|Clostridia,36EFY@31979|Clostridiaceae	186801|Clostridia	L	Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity	mutS2	-	-	ko:K07456	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_V,Smr
HKD2_k127_6475211_4	1292035.H476_0400	2.276e-44	165.0	COG1683@1|root,COG1683@2|Bacteria,1V700@1239|Firmicutes,24JD2@186801|Clostridia,25RKG@186804|Peptostreptococcaceae	186801|Clostridia	S	Protein of unknown function (DUF523)	-	-	-	-	-	-	-	-	-	-	-	-	DUF523
HKD2_k127_6475211_2	756499.Desde_1008	7.935e-79	273.0	COG0583@1|root,COG1910@1|root,COG0583@2|Bacteria,COG1910@2|Bacteria,1TSA6@1239|Firmicutes,24BM8@186801|Clostridia,26291@186807|Peptococcaceae	186801|Clostridia	K	PFAM Bacterial regulatory helix-turn-helix protein, lysR family	cmpR	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HKD2_k127_6485934_11	573061.Clocel_0587	1.039e-17	87.0	COG2733@1|root,COG2733@2|Bacteria,1V1AB@1239|Firmicutes,24G52@186801|Clostridia,36JCI@31979|Clostridiaceae	186801|Clostridia	S	Protein of unknown function (DUF445)	-	-	-	-	-	-	-	-	-	-	-	-	DUF445
HKD2_k127_6485934_7	608506.COB47_0806	6.116e-60	215.0	COG0398@1|root,COG0398@2|Bacteria,1VC9M@1239|Firmicutes,25CNK@186801|Clostridia,42JF6@68295|Thermoanaerobacterales	186801|Clostridia	S	PFAM SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
HKD2_k127_6485934_6	1499689.CCNN01000014_gene3270	9.067e-72	246.0	2B66C@1|root,31Z3H@2|Bacteria,1V6U0@1239|Firmicutes,24ICU@186801|Clostridia,36J7Y@31979|Clostridiaceae	186801|Clostridia	S	Psort location Cytoplasmic, score 8.87	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6485934_1	1487921.DP68_17125	1.239e-159	518.0	COG5002@1|root,COG5002@2|Bacteria,1TPSK@1239|Firmicutes,24A2N@186801|Clostridia,36EDC@31979|Clostridiaceae	186801|Clostridia	T	Histidine kinase	arlS	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
HKD2_k127_6485934_4	1487921.DP68_17130	5.553e-108	353.0	COG0745@1|root,COG0745@2|Bacteria,1TS81@1239|Firmicutes,248XH@186801|Clostridia,36EJ3@31979|Clostridiaceae	186801|Clostridia	T	response regulator, receiver	arlR	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
HKD2_k127_6485934_10	1487921.DP68_17135	9.142e-35	138.0	COG0264@1|root,COG0264@2|Bacteria,1VGFM@1239|Firmicutes,24JNW@186801|Clostridia,36W3M@31979|Clostridiaceae	186801|Clostridia	J	Domain of unknown function (DUF4342)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4342
HKD2_k127_6485934_3	755731.Clo1100_2877	4.528e-124	410.0	COG1668@1|root,COG1668@2|Bacteria,1TXRK@1239|Firmicutes,248YS@186801|Clostridia,36GJ2@31979|Clostridiaceae	186801|Clostridia	CP	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
HKD2_k127_6485934_2	509191.AEDB02000043_gene4722	6.424e-134	433.0	COG4152@1|root,COG4152@2|Bacteria,1TR06@1239|Firmicutes,249YC@186801|Clostridia,3WGIK@541000|Ruminococcaceae	186801|Clostridia	S	Domain of unknown function (DUF4162)	natA	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
HKD2_k127_6485934_0	1226325.HMPREF1548_05114	4.421e-169	540.0	COG1690@1|root,COG1690@2|Bacteria,1TPJ2@1239|Firmicutes,2481V@186801|Clostridia,36EU8@31979|Clostridiaceae	186801|Clostridia	S	tRNA-splicing ligase RtcB	-	-	6.5.1.3	ko:K14415	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RtcB
HKD2_k127_6485934_5	1262449.CP6013_2780	9.187e-85	296.0	COG2378@1|root,COG2378@2|Bacteria,1TQYS@1239|Firmicutes,24B1B@186801|Clostridia,36FSW@31979|Clostridiaceae	186801|Clostridia	K	WYL domain	-	-	-	-	-	-	-	-	-	-	-	-	WYL
HKD2_k127_6485934_8	272562.CA_C3386	8.755e-60	219.0	2DBKZ@1|root,2Z9WA@2|Bacteria,1TRUJ@1239|Firmicutes,24ATT@186801|Clostridia,36I4E@31979|Clostridiaceae	186801|Clostridia	S	WYL domain	-	-	-	-	-	-	-	-	-	-	-	-	WYL
HKD2_k127_6485934_9	457421.CBFG_04174	4.475e-40	150.0	COG0330@1|root,COG0330@2|Bacteria,1TR6S@1239|Firmicutes,24A7V@186801|Clostridia	186801|Clostridia	O	prohibitin homologues	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
HKD2_k127_6487633_0	1347392.CCEZ01000049_gene1646	0.0	1377.0	COG0178@1|root,COG0178@2|Bacteria,1TPIJ@1239|Firmicutes,2485F@186801|Clostridia,36E0I@31979|Clostridiaceae	186801|Clostridia	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
HKD2_k127_6487633_1	350688.Clos_2258	9.116e-315	974.0	COG0556@1|root,COG0556@2|Bacteria,1TPKB@1239|Firmicutes,247P7@186801|Clostridia,36DSR@31979|Clostridiaceae	186801|Clostridia	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	-	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
HKD2_k127_6487633_18	272562.CA_C3236	2.447e-30	132.0	COG2508@1|root,COG2508@2|Bacteria,1TTA0@1239|Firmicutes,248HN@186801|Clostridia,36EQB@31979|Clostridiaceae	186801|Clostridia	QT	PucR C-terminal helix-turn-helix domain	cdaR_3	-	-	ko:K02647	-	-	-	-	ko00000,ko03000	-	-	-	HTH_30
HKD2_k127_6487633_2	1304880.JAGB01000003_gene1024	6.82e-159	508.0	COG3842@1|root,COG3842@2|Bacteria,1TP2M@1239|Firmicutes,247JR@186801|Clostridia	186801|Clostridia	P	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system	msmX	-	-	ko:K10112	ko02010,map02010	M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1	-	-	ABC_tran,TOBE,TOBE_2
HKD2_k127_6487633_8	935948.KE386494_gene407	2.595e-98	335.0	COG0265@1|root,COG0265@2|Bacteria,1TSBA@1239|Firmicutes,24BC4@186801|Clostridia,42EMZ@68295|Thermoanaerobacterales	186801|Clostridia	O	PDZ DHR GLGF domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PDZ,PDZ_2
HKD2_k127_6487633_5	1304284.L21TH_2464	1.13e-112	376.0	COG0793@1|root,COG0793@2|Bacteria,1TPBI@1239|Firmicutes,248HZ@186801|Clostridia,36DGU@31979|Clostridiaceae	186801|Clostridia	M	Belongs to the peptidase S41A family	ctpA	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_S41
HKD2_k127_6487633_17	293826.Amet_2333	1.027e-35	140.0	COG0735@1|root,COG0735@2|Bacteria,1V6RI@1239|Firmicutes,24PHW@186801|Clostridia,36KUM@31979|Clostridiaceae	186801|Clostridia	P	Ferric uptake regulator family	-	-	-	ko:K02076,ko:K03711	-	-	-	-	ko00000,ko03000	-	-	-	FUR
HKD2_k127_6487633_13	293826.Amet_1174	9.576e-84	286.0	COG1108@1|root,COG1108@2|Bacteria,1TR79@1239|Firmicutes,24875@186801|Clostridia,36EWA@31979|Clostridiaceae	186801|Clostridia	P	ABC 3 transport family	adcB	-	-	ko:K09816	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	ABC-3
HKD2_k127_6487633_14	293826.Amet_1173	6.964e-82	279.0	COG1121@1|root,COG1121@2|Bacteria,1TQ68@1239|Firmicutes,248F1@186801|Clostridia,36I3C@31979|Clostridiaceae	186801|Clostridia	P	ABC transporter	zurA	-	-	ko:K09817	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	ABC_tran
HKD2_k127_6487633_12	546269.HMPREF0389_00054	8.541e-84	288.0	COG0803@1|root,COG0803@2|Bacteria,1TPG7@1239|Firmicutes,249VZ@186801|Clostridia,25R39@186804|Peptostreptococcaceae	186801|Clostridia	P	Belongs to the bacterial solute-binding protein 9 family	adcA	-	-	ko:K09815	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	ZnuA
HKD2_k127_6487633_10	1304284.L21TH_2463	1.038e-93	320.0	COG4942@1|root,COG4942@2|Bacteria,1TQ5I@1239|Firmicutes,248ZG@186801|Clostridia,36FVZ@31979|Clostridiaceae	186801|Clostridia	D	Peptidase, M23	-	-	-	ko:K21471	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_M23
HKD2_k127_6487633_15	935948.KE386494_gene410	2.08e-71	252.0	COG2177@1|root,COG2177@2|Bacteria,1TPND@1239|Firmicutes,24AA6@186801|Clostridia,42FMA@68295|Thermoanaerobacterales	186801|Clostridia	D	Part of the ABC transporter FtsEX involved in asymmetric cellular division facilitating the initiation of sporulation	ftsX	-	-	ko:K09811	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	FtsX
HKD2_k127_6487633_11	1408422.JHYF01000003_gene863	1.826e-91	306.0	COG2884@1|root,COG2884@2|Bacteria,1TP58@1239|Firmicutes,248HW@186801|Clostridia,36DHJ@31979|Clostridiaceae	186801|Clostridia	D	cell division ATP-binding protein FtsE	ftsE	-	-	ko:K09812	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	ABC_tran
HKD2_k127_6487633_19	1410653.JHVC01000001_gene1636	3.936e-24	111.0	COG0671@1|root,COG0671@2|Bacteria,1VF2U@1239|Firmicutes,24D98@186801|Clostridia,36I34@31979|Clostridiaceae	186801|Clostridia	I	Acid phosphatase homologues	-	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2,SNARE_assoc
HKD2_k127_6487633_3	1321778.HMPREF1982_02749	1.926e-153	495.0	COG0477@1|root,COG2814@2|Bacteria,1TQDU@1239|Firmicutes,25ESY@186801|Clostridia	186801|Clostridia	EGP	Major Facilitator	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,PUCC,Sugar_tr
HKD2_k127_6487633_20	398512.JQKC01000005_gene5642	8.799e-21	93.0	COG4844@1|root,COG4844@2|Bacteria,1VGGH@1239|Firmicutes,24RAS@186801|Clostridia	186801|Clostridia	S	Protein of unknown function (DUF1450)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1450
HKD2_k127_6487633_16	536227.CcarbDRAFT_3722	2.059e-53	189.0	COG0073@1|root,COG0073@2|Bacteria,1V6N9@1239|Firmicutes,24JJZ@186801|Clostridia,36K08@31979|Clostridiaceae	186801|Clostridia	J	PFAM t-RNA-binding domain protein	csaA	-	-	ko:K06878	-	-	-	-	ko00000	-	-	-	tRNA_bind
HKD2_k127_6487633_9	373903.Hore_08350	1.245e-96	325.0	COG0705@1|root,COG0705@2|Bacteria,1TSBP@1239|Firmicutes,249D8@186801|Clostridia	186801|Clostridia	S	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
HKD2_k127_6487633_4	536232.CLM_1990	3.772e-123	404.0	COG0309@1|root,COG0309@2|Bacteria,1TQP4@1239|Firmicutes,24963@186801|Clostridia,36GDV@31979|Clostridiaceae	186801|Clostridia	O	PFAM AIR synthase related protein	hypE	-	-	ko:K04655	-	-	-	-	ko00000	-	-	-	AIRS,AIRS_C
HKD2_k127_6487633_6	290402.Cbei_3007	3.317e-111	369.0	COG0409@1|root,COG0409@2|Bacteria,1TPM7@1239|Firmicutes,248EX@186801|Clostridia,36FKI@31979|Clostridiaceae	186801|Clostridia	O	hydrogenase expression formation protein HypD	hypD	-	-	ko:K04654	-	-	-	-	ko00000	-	-	-	HypD
HKD2_k127_6487633_21	536232.CLM_1992	2.118e-12	71.0	COG0298@1|root,COG0298@2|Bacteria,1VFE0@1239|Firmicutes,24UXU@186801|Clostridia,36NYN@31979|Clostridiaceae	186801|Clostridia	O	Hydrogenase assembly chaperone hypC hupF	hypC	-	-	ko:K04653	-	-	-	-	ko00000	-	-	-	HupF_HypC
HKD2_k127_6487633_7	693746.OBV_07160	1.373e-99	334.0	COG0068@1|root,COG0068@2|Bacteria,1TQM7@1239|Firmicutes,2494A@186801|Clostridia	186801|Clostridia	O	Belongs to the carbamoyltransferase HypF family	hypF	-	-	ko:K04656	-	-	-	-	ko00000	-	-	-	Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF
HKD2_k127_6492641_0	1410653.JHVC01000002_gene4198	1.327e-112	366.0	COG0183@1|root,COG0183@2|Bacteria,1TP07@1239|Firmicutes,2482I@186801|Clostridia,36DVG@31979|Clostridiaceae	186801|Clostridia	I	Belongs to the thiolase family	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
HKD2_k127_6492641_1	398512.JQKC01000010_gene90	3.217e-81	277.0	COG2071@1|root,COG2071@2|Bacteria,1V1KC@1239|Firmicutes,24JCU@186801|Clostridia,3WIV9@541000|Ruminococcaceae	186801|Clostridia	F	peptidase C26	-	-	-	ko:K07010	-	-	-	-	ko00000,ko01002	-	-	-	Peptidase_C26
HKD2_k127_6492641_2	357809.Cphy_2416	1.22e-28	115.0	COG3384@1|root,COG3384@2|Bacteria,1TSRZ@1239|Firmicutes,24B3B@186801|Clostridia,220WF@1506553|Lachnoclostridium	186801|Clostridia	S	PFAM Extradiol ring-cleavage dioxygenase class III protein subunit B	-	-	-	ko:K15777	ko00965,map00965	-	R08836	RC00387	ko00000,ko00001,ko01000	-	-	-	LigB
HKD2_k127_64929_2	545243.BAEV01000003_gene3370	1.021e-105	355.0	COG2206@1|root,COG2206@2|Bacteria,1TS2E@1239|Firmicutes,249S8@186801|Clostridia,36F71@31979|Clostridiaceae	186801|Clostridia	T	PFAM metal-dependent phosphohydrolase HD sub domain	-	-	-	-	-	-	-	-	-	-	-	-	HD,HD_5
HKD2_k127_64929_1	1121289.JHVL01000027_gene220	2.097e-136	448.0	COG1167@1|root,COG1167@2|Bacteria,1TPS5@1239|Firmicutes,248ZB@186801|Clostridia,36EK3@31979|Clostridiaceae	186801|Clostridia	K	aminotransferase class I and II	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2,GntR
HKD2_k127_64929_4	1042163.BRLA_c005670	3.662e-63	228.0	COG0823@1|root,COG0823@2|Bacteria,1VBSM@1239|Firmicutes,4IQEP@91061|Bacilli	91061|Bacilli	U	Domain of unknown function (DUF5050)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5050
HKD2_k127_64929_3	1120746.CCNL01000014_gene2158	3.927e-104	342.0	COG0020@1|root,COG0020@2|Bacteria,2NQPS@2323|unclassified Bacteria	2|Bacteria	I	Putative undecaprenyl diphosphate synthase	uppS2	-	2.5.1.31	ko:K00806	ko00900,ko01110,map00900,map01110	-	R06447	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
HKD2_k127_64929_0	755731.Clo1100_2742	4e-144	470.0	COG0617@1|root,COG0617@2|Bacteria,1TQ2A@1239|Firmicutes,247XC@186801|Clostridia,36FRJ@31979|Clostridiaceae	186801|Clostridia	J	tRNA nucleotidyltransferase poly(A) polymerase	cca	-	2.7.7.19,2.7.7.72	ko:K00970,ko:K00974	ko03013,ko03018,map03013,map03018	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	HD,PolyA_pol,PolyA_pol_RNAbd,tRNA_NucTran2_2
HKD2_k127_64929_5	431943.CKL_3616	3.362e-07	56.0	2EJ6V@1|root,33CY2@2|Bacteria,1VPDN@1239|Firmicutes,24PMK@186801|Clostridia,36M4P@31979|Clostridiaceae	186801|Clostridia	S	Yip1 domain	-	-	-	-	-	-	-	-	-	-	-	-	Yip1
HKD2_k127_6500893_0	445973.CLOBAR_02789	9.09e-143	466.0	COG1625@1|root,COG1625@2|Bacteria,1TSFU@1239|Firmicutes,247JK@186801|Clostridia,25SXA@186804|Peptostreptococcaceae	186801|Clostridia	C	Protein of unknown function (DUF512)	-	-	-	-	-	-	-	-	-	-	-	-	DUF512
HKD2_k127_6500893_1	1230342.CTM_05940	1.734e-69	238.0	COG1160@1|root,COG1160@2|Bacteria,1TPNM@1239|Firmicutes,2493T@186801|Clostridia,36DFQ@31979|Clostridiaceae	186801|Clostridia	S	GTPase that plays an essential role in the late steps of ribosome biogenesis	der	-	-	ko:K03977	-	-	-	-	ko00000,ko03009	-	-	-	KH_dom-like,MMR_HSR1
HKD2_k127_6512779_0	1304284.L21TH_0349	1.952e-110	365.0	COG2066@1|root,COG2066@2|Bacteria,1TP64@1239|Firmicutes,2491K@186801|Clostridia,36EFX@31979|Clostridiaceae	186801|Clostridia	E	Belongs to the glutaminase family	glsA	-	3.5.1.2	ko:K01425	ko00220,ko00250,ko00471,ko01100,ko04724,ko04727,ko04964,ko05206,ko05230,map00220,map00250,map00471,map01100,map04724,map04727,map04964,map05206,map05230	-	R00256,R01579	RC00010,RC02798	ko00000,ko00001,ko01000	-	-	-	Glutaminase
HKD2_k127_6517347_9	1321778.HMPREF1982_02788	6.269e-125	403.0	COG0505@1|root,COG0505@2|Bacteria,1TQ8N@1239|Firmicutes,247Q8@186801|Clostridia,267Y9@186813|unclassified Clostridiales	186801|Clostridia	EF	Carbamoyl-phosphate synthase small chain, CPSase domain	carA	-	6.3.5.5	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_sm_chain,GATase
HKD2_k127_6517347_2	1304284.L21TH_1158	3.645e-272	849.0	COG1523@1|root,COG1523@2|Bacteria,1TP3M@1239|Firmicutes,2481P@186801|Clostridia,36E5I@31979|Clostridiaceae	186801|Clostridia	G	Belongs to the glycosyl hydrolase 13 family	pulA	-	3.2.1.41	ko:K01200	ko00500,ko01100,ko01110,map00500,map01100,map01110	-	R02111	-	ko00000,ko00001,ko01000	-	CBM48,GH13	-	Alpha-amylase,Big_2,CBM_48,DUF3372,PUD
HKD2_k127_6517347_0	1121324.CLIT_5c00480	0.0	1039.0	COG0058@1|root,COG0058@2|Bacteria,1TQAJ@1239|Firmicutes,248E1@186801|Clostridia,25QJN@186804|Peptostreptococcaceae	186801|Clostridia	G	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties	glgP	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	Phosphorylase
HKD2_k127_6517347_3	1304284.L21TH_1358	2.892e-218	685.0	COG0297@1|root,COG0297@2|Bacteria,1TQ4M@1239|Firmicutes,248G1@186801|Clostridia,36E5E@31979|Clostridiaceae	186801|Clostridia	G	Synthesizes alpha-1,4-glucan chains using ADP-glucose	glgA	-	2.4.1.21	ko:K00703	ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026	M00565	R02421	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT5	-	Glyco_transf_5,Glycos_transf_1
HKD2_k127_6517347_7	1304284.L21TH_1359	2.612e-134	437.0	COG0448@1|root,COG0448@2|Bacteria,1TPZ3@1239|Firmicutes,2482Q@186801|Clostridia,36FAK@31979|Clostridiaceae	186801|Clostridia	G	Glucose-1-phosphate adenylyltransferase, GlgD subunit	glgD	-	2.7.7.27	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	M00565	R00948	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
HKD2_k127_6517347_5	1304284.L21TH_1360	1.644e-170	542.0	COG0448@1|root,COG0448@2|Bacteria,1TNZW@1239|Firmicutes,24943@186801|Clostridia,36DKC@31979|Clostridiaceae	186801|Clostridia	H	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans	glgC	-	2.7.7.27	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	M00565	R00948	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase
HKD2_k127_6517347_1	1304284.L21TH_1361	5.713e-274	857.0	COG0296@1|root,COG0296@2|Bacteria,1TP4M@1239|Firmicutes,247WH@186801|Clostridia,36EUN@31979|Clostridiaceae	186801|Clostridia	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position	glgB	-	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48
HKD2_k127_6517347_8	1121289.JHVL01000005_gene1024	5.988e-132	439.0	COG4641@1|root,COG4641@2|Bacteria,1TQDC@1239|Firmicutes,24C5S@186801|Clostridia,36F27@31979|Clostridiaceae	186801|Clostridia	M	DUF based on E. rectale Gene description (DUF3880)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3880,Glyco_trans_1_2,Glycos_transf_2
HKD2_k127_6517347_6	1415774.U728_2162	1.369e-141	460.0	COG0677@1|root,COG0677@2|Bacteria,1TPXY@1239|Firmicutes,248NW@186801|Clostridia,36FEX@31979|Clostridiaceae	186801|Clostridia	M	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	wecC	-	1.1.1.336	ko:K02472	ko00520,ko05111,map00520,map05111	-	R03317	RC00291	ko00000,ko00001,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
HKD2_k127_6517347_4	1347392.CCEZ01000075_gene3179	1.475e-212	666.0	COG0677@1|root,COG0677@2|Bacteria,1TPXY@1239|Firmicutes,248NW@186801|Clostridia,36FEX@31979|Clostridiaceae	186801|Clostridia	M	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	-	-	-	ko:K02474	ko00520,map00520	-	R06894	RC00291	ko00000,ko00001,ko01000,ko01005	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
HKD2_k127_6517347_10	693746.OBV_39250	2.331e-59	211.0	COG1215@1|root,COG4641@1|root,COG1215@2|Bacteria,COG4641@2|Bacteria,1TQDC@1239|Firmicutes,24C5S@186801|Clostridia	186801|Clostridia	M	DUF based on E. rectale Gene description (DUF3880)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3880,Glyco_trans_1_2,Glycos_transf_2
HKD2_k127_6545969_3	858215.Thexy_1145	5.678e-61	213.0	COG0735@1|root,COG0735@2|Bacteria,1V7F0@1239|Firmicutes,24JQE@186801|Clostridia,42G3F@68295|Thermoanaerobacterales	186801|Clostridia	P	Ferric uptake regulator, Fur family	fur	-	-	ko:K03711	-	-	-	-	ko00000,ko03000	-	-	-	FUR
HKD2_k127_6545969_0	273068.TTE1253	5.845e-268	833.0	COG0595@1|root,COG0595@2|Bacteria,1TQ9G@1239|Firmicutes,2488J@186801|Clostridia,42F33@68295|Thermoanaerobacterales	186801|Clostridia	S	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay	rnj	-	-	ko:K12574	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	Lactamase_B,RMMBL
HKD2_k127_6545969_2	1487923.DP73_09360	5.208e-91	308.0	COG1597@1|root,COG1597@2|Bacteria,1TQAU@1239|Firmicutes,25CN4@186801|Clostridia,2676X@186807|Peptococcaceae	186801|Clostridia	I	Diacylglycerol kinase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	DAGK_cat
HKD2_k127_6545969_1	580327.Tthe_1108	3.917e-160	509.0	COG1217@1|root,COG1217@2|Bacteria,1TQ5Y@1239|Firmicutes,248EB@186801|Clostridia,42EYB@68295|Thermoanaerobacterales	186801|Clostridia	T	PFAM Protein synthesis factor, GTP-binding	typA	-	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,EFG_II,GTP_EFTU,GTP_EFTU_D2
HKD2_k127_6547655_0	555079.Toce_1516	1.53e-122	397.0	2BYY4@1|root,2Z80Y@2|Bacteria,1TSXF@1239|Firmicutes,24B6G@186801|Clostridia,42HNK@68295|Thermoanaerobacterales	186801|Clostridia	S	Domain of unknown function (DUF4438)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4438
HKD2_k127_6547655_2	1131462.DCF50_p1407	2.083e-30	121.0	COG4443@1|root,COG4443@2|Bacteria,1VEFE@1239|Firmicutes,24QV3@186801|Clostridia,265UM@186807|Peptococcaceae	186801|Clostridia	S	Transcriptional Coactivator p15 (PC4)	-	-	-	-	-	-	-	-	-	-	-	-	PC4
HKD2_k127_6547655_1	755731.Clo1100_0250	1.046e-49	183.0	COG1472@1|root,COG1472@2|Bacteria,1TP63@1239|Firmicutes,24YIP@186801|Clostridia,36W7H@31979|Clostridiaceae	186801|Clostridia	G	hydrolase, family 3	-	-	3.2.1.52	ko:K01207	ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501	M00628	R00022,R05963,R07809,R07810,R10831	RC00049	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyco_hydro_3
HKD2_k127_6555144_15	398512.JQKC01000007_gene1142	8.213e-25	110.0	COG3144@1|root,COG3144@2|Bacteria,1VAP1@1239|Firmicutes,24RF8@186801|Clostridia,3WMXB@541000|Ruminococcaceae	186801|Clostridia	N	PFAM Flagellar hook-length control	fliK	-	-	ko:K02414	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_hook
HKD2_k127_6555144_14	1195236.CTER_2661	1.071e-25	114.0	COG1843@1|root,COG1843@2|Bacteria,1VF85@1239|Firmicutes,24QKD@186801|Clostridia,3WMD4@541000|Ruminococcaceae	186801|Clostridia	N	Required for flagellar hook formation. May act as a scaffolding protein	flgD	-	-	ko:K02389	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FLgD_tudor,FlgD
HKD2_k127_6555144_12	350688.Clos_1487	1.483e-29	121.0	2E35U@1|root,32Y5R@2|Bacteria,1VEH9@1239|Firmicutes,24R2S@186801|Clostridia,36KRJ@31979|Clostridiaceae	186801|Clostridia	N	flagellar operon protein	flg	-	-	-	-	-	-	-	-	-	-	-	Flagellar_put
HKD2_k127_6555144_1	1408422.JHYF01000001_gene2984	3.977e-141	461.0	COG1749@1|root,COG1749@2|Bacteria,1UHS7@1239|Firmicutes,247ZT@186801|Clostridia,36UNE@31979|Clostridiaceae	186801|Clostridia	N	flagellar basal body	flgE	-	-	ko:K02390	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FlaE,Flg_bb_rod,Flg_bbr_C
HKD2_k127_6555144_16	857293.CAAU_0521	2.767e-15	77.0	COG1582@1|root,COG1582@2|Bacteria	2|Bacteria	N	Flagellar protein (FlbD)	flbD	-	-	ko:K02385	-	-	-	-	ko00000,ko02035	-	-	-	FlbD
HKD2_k127_6555144_7	1347392.CCEZ01000043_gene324	3.457e-91	306.0	COG1291@1|root,COG1291@2|Bacteria,1TRH1@1239|Firmicutes,24AEJ@186801|Clostridia,36E57@31979|Clostridiaceae	186801|Clostridia	N	PFAM MotA TolQ ExbB proton channel	motA	-	-	ko:K02556	ko02020,ko02030,ko02040,map02020,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1	-	-	MotA_ExbB
HKD2_k127_6555144_10	1209989.TepiRe1_1341	1.178e-62	223.0	COG1360@1|root,COG1360@2|Bacteria,1V8KE@1239|Firmicutes,24GQQ@186801|Clostridia,42GA3@68295|Thermoanaerobacterales	186801|Clostridia	N	PFAM OmpA MotB domain protein	motB	-	-	ko:K02557	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1	-	-	MotB_plug,OmpA
HKD2_k127_6555144_18	340099.Teth39_1246	3.476e-11	69.0	COG1580@1|root,COG1580@2|Bacteria,1V9J2@1239|Firmicutes,24J8W@186801|Clostridia,42GMM@68295|Thermoanaerobacterales	186801|Clostridia	N	Controls the rotational direction of flagella during chemotaxis	fliL	-	-	ko:K02415	-	-	-	-	ko00000,ko02035	-	-	-	FliL
HKD2_k127_6555144_3	632292.Calhy_0595	1.125e-116	384.0	COG1868@1|root,COG1868@2|Bacteria,1TPTM@1239|Firmicutes,24AGV@186801|Clostridia,42F9C@68295|Thermoanaerobacterales	186801|Clostridia	N	flagellar motor switch protein FliM	fliM	-	-	ko:K02416	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliM,FliMN_C
HKD2_k127_6555144_2	755731.Clo1100_2398	5.395e-127	417.0	COG1776@1|root,COG1886@1|root,COG1776@2|Bacteria,COG1886@2|Bacteria,1TPT8@1239|Firmicutes,24821@186801|Clostridia,36FD2@31979|Clostridiaceae	186801|Clostridia	N	flagellar motor switch protein	fliN	-	-	ko:K02417	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	CheC,FliMN_C
HKD2_k127_6555144_11	350688.Clos_1495	8.04e-60	208.0	COG2204@1|root,COG2204@2|Bacteria,1UHXE@1239|Firmicutes,25E6A@186801|Clostridia,36UNF@31979|Clostridiaceae	186801|Clostridia	T	cheY-homologous receiver domain	cheY	-	-	ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	Response_reg
HKD2_k127_6555144_19	889378.Spiaf_2090	1.323e-06	57.0	COG3190@1|root,COG3190@2|Bacteria,2J8HN@203691|Spirochaetes	203691|Spirochaetes	N	Flagellar biosynthesis protein, FliO	-	-	-	ko:K02418	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	FliO
HKD2_k127_6555144_5	1449126.JQKL01000001_gene1342	6.069e-97	323.0	COG1338@1|root,COG1338@2|Bacteria,1TPIE@1239|Firmicutes,2487C@186801|Clostridia,268V4@186813|unclassified Clostridiales	186801|Clostridia	N	Plays a role in the flagellum-specific transport system	fliP	-	-	ko:K02419	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	FliP
HKD2_k127_6555144_13	1123511.KB905845_gene2772	8.708e-26	108.0	COG1987@1|root,COG1987@2|Bacteria,1VEHF@1239|Firmicutes,4H54Q@909932|Negativicutes	909932|Negativicutes	N	Flagellar biosynthetic protein FliQ	fliQ	-	-	ko:K02420	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	Bac_export_3
HKD2_k127_6555144_9	580327.Tthe_1438	4.024e-69	243.0	COG1684@1|root,COG1684@2|Bacteria,1TRB2@1239|Firmicutes,24ECW@186801|Clostridia,42GHB@68295|Thermoanaerobacterales	186801|Clostridia	N	Flagellar biosynthetic protein FliR	fliR	-	-	ko:K02421	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	Bac_export_1
HKD2_k127_6555144_4	203119.Cthe_0484	7.793e-113	374.0	COG1377@1|root,COG1377@2|Bacteria,1TPRP@1239|Firmicutes,248N7@186801|Clostridia,3WI89@541000|Ruminococcaceae	186801|Clostridia	N	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin	flhB	-	-	ko:K02401,ko:K13820	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	Bac_export_1,Bac_export_2
HKD2_k127_6555144_0	1121289.JHVL01000003_gene2208	1.91e-284	887.0	COG1298@1|root,COG1298@2|Bacteria,1TQBM@1239|Firmicutes,248F5@186801|Clostridia,36EDM@31979|Clostridiaceae	186801|Clostridia	N	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin	flhA	-	-	ko:K02400	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	FHIPEP
HKD2_k127_6555144_8	1304880.JAGB01000001_gene207	1.557e-88	308.0	COG1419@1|root,COG1419@2|Bacteria,1TSP7@1239|Firmicutes,249R1@186801|Clostridia	186801|Clostridia	N	PFAM GTP-binding signal recognition particle SRP54 G- domain	flhF	-	-	ko:K02404	-	-	-	-	ko00000,ko02035	-	-	-	SRP54
HKD2_k127_6555144_6	509191.AEDB02000074_gene1778	2.256e-93	315.0	COG0455@1|root,COG0455@2|Bacteria,1TRZ5@1239|Firmicutes,24AIN@186801|Clostridia,3WMZV@541000|Ruminococcaceae	186801|Clostridia	D	Belongs to the ParA family	flhG	-	-	ko:K04562	-	-	-	-	ko00000,ko02035	-	-	-	CbiA,ParA
HKD2_k127_6555144_17	858215.Thexy_1310	7.724e-14	79.0	COG5581@1|root,COG5581@2|Bacteria,1VERW@1239|Firmicutes,24NU7@186801|Clostridia,42GFE@68295|Thermoanaerobacterales	186801|Clostridia	M	PFAM type IV pilus assembly PilZ	pilZ	-	-	-	-	-	-	-	-	-	-	-	PilZ,YcgR_2
HKD2_k127_6559576_3	865861.AZSU01000005_gene915	1.837e-59	210.0	COG2461@1|root,COG2461@2|Bacteria,1TRD5@1239|Firmicutes,24CKX@186801|Clostridia,36RB5@31979|Clostridiaceae	186801|Clostridia	S	PAS domain	-	-	-	ko:K09155	-	-	-	-	ko00000	-	-	-	DUF1858,DUF2249,DUF438,Hemerythrin,PAS_10
HKD2_k127_6559576_1	1321778.HMPREF1982_00417	5.173e-145	464.0	COG1917@1|root,COG2207@1|root,COG1917@2|Bacteria,COG2207@2|Bacteria,1UZ8Y@1239|Firmicutes,248SM@186801|Clostridia	186801|Clostridia	K	transcriptional regulator (AraC family)	-	-	-	-	-	-	-	-	-	-	-	-	AraC_binding,HTH_18
HKD2_k127_6559576_0	536227.CcarbDRAFT_3617	5.004e-173	552.0	COG1301@1|root,COG1301@2|Bacteria,1TQ3F@1239|Firmicutes,25CGZ@186801|Clostridia,36WVU@31979|Clostridiaceae	186801|Clostridia	C	Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family	-	-	-	-	-	-	-	-	-	-	-	-	SDF
HKD2_k127_6559576_4	931626.Awo_c18130	4.144e-56	209.0	COG3437@1|root,COG3437@2|Bacteria,1UQJH@1239|Firmicutes,248UM@186801|Clostridia,25V1R@186806|Eubacteriaceae	186801|Clostridia	T	Psort location Cytoplasmic, score	-	-	-	ko:K07814	-	-	-	-	ko00000,ko02022	-	-	-	GGDEF,HD,HD_5,Response_reg
HKD2_k127_6559576_2	1121904.ARBP01000018_gene2606	8.742e-60	227.0	COG4191@1|root,COG4191@2|Bacteria,4NE4T@976|Bacteroidetes,47K96@768503|Cytophagia	976|Bacteroidetes	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
HKD2_k127_6572344_3	1033737.CAEV01000020_gene977	1.172e-48	177.0	COG1576@1|root,COG1576@2|Bacteria,1V3JM@1239|Firmicutes,24HED@186801|Clostridia,36I0G@31979|Clostridiaceae	186801|Clostridia	J	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA	rlmH	-	2.1.1.177	ko:K00783	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SPOUT_MTase
HKD2_k127_6572344_1	935948.KE386494_gene898	3.656e-113	378.0	COG0265@1|root,COG0265@2|Bacteria,1TRM8@1239|Firmicutes,247M5@186801|Clostridia,42EX9@68295|Thermoanaerobacterales	186801|Clostridia	O	smart pdz dhr glgf	htrA	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
HKD2_k127_6572344_2	1031288.AXAA01000015_gene302	1.201e-94	317.0	COG1235@1|root,COG1235@2|Bacteria,1TQ8E@1239|Firmicutes,249U2@186801|Clostridia,36FFE@31979|Clostridiaceae	186801|Clostridia	S	domain protein	yycJ	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B,Lactamase_B_2
HKD2_k127_6572344_0	1408422.JHYF01000006_gene1063	6.371e-174	554.0	COG0766@1|root,COG0766@2|Bacteria,1TPAU@1239|Firmicutes,2488W@186801|Clostridia,36DC0@31979|Clostridiaceae	186801|Clostridia	M	Belongs to the EPSP synthase family. MurA subfamily	murA	-	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase
HKD2_k127_6576508_2	857293.CAAU_0147	1.027e-151	485.0	COG1609@1|root,COG1609@2|Bacteria,1TRFH@1239|Firmicutes,24A4M@186801|Clostridia,36DDD@31979|Clostridiaceae	186801|Clostridia	K	helix_turn _helix lactose operon repressor	-	-	-	ko:K02529,ko:K03604	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
HKD2_k127_6576508_0	857293.CAAU_0148	4.591e-252	785.0	COG3507@1|root,COG3507@2|Bacteria,1TP5K@1239|Firmicutes,247R2@186801|Clostridia,36ES1@31979|Clostridiaceae	186801|Clostridia	G	Belongs to the glycosyl hydrolase 43 family	-	-	3.2.1.37	ko:K01198	ko00520,ko01100,map00520,map01100	-	R01433	RC00467	ko00000,ko00001,ko01000	-	GH43	-	DUF1349,Glyco_hydro_43
HKD2_k127_6576508_4	857293.CAAU_0149	7.154e-135	434.0	COG0395@1|root,COG0395@2|Bacteria,1TS0R@1239|Firmicutes,248UX@186801|Clostridia,36FNN@31979|Clostridiaceae	186801|Clostridia	G	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02026,ko:K10242	ko02010,map02010	M00206,M00207	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.23	-	-	BPD_transp_1
HKD2_k127_6576508_3	857293.CAAU_0150	1.127e-151	484.0	COG1175@1|root,COG1175@2|Bacteria,1TS63@1239|Firmicutes,2489M@186801|Clostridia,36H73@31979|Clostridiaceae	186801|Clostridia	G	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
HKD2_k127_6576508_1	857293.CAAU_0151	1.632e-242	756.0	COG1653@1|root,COG1653@2|Bacteria,1TRPJ@1239|Firmicutes,24872@186801|Clostridia,36F95@31979|Clostridiaceae	186801|Clostridia	G	solute-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_8
HKD2_k127_6576795_0	573413.Spirs_1853	6.849e-239	752.0	COG1178@1|root,COG1178@2|Bacteria,2J5J4@203691|Spirochaetes	203691|Spirochaetes	P	ABC transporter permease	-	-	-	ko:K02011	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	BPD_transp_1
HKD2_k127_6576795_1	1449063.JMLS01000009_gene2222	5.332e-143	462.0	COG3842@1|root,COG3842@2|Bacteria,1TP2M@1239|Firmicutes,4I6VB@91061|Bacilli,26V55@186822|Paenibacillaceae	91061|Bacilli	E	ATPases associated with a variety of cellular activities	-	-	-	ko:K10112	ko02010,map02010	M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1	-	-	ABC_tran
HKD2_k127_6576795_2	1123274.KB899415_gene2470	4.002e-125	412.0	COG1840@1|root,COG1840@2|Bacteria,2J7IK@203691|Spirochaetes	203691|Spirochaetes	P	Bacterial extracellular solute-binding protein	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_11,SBP_bac_8
HKD2_k127_6576795_3	1169144.KB910952_gene3212	4.069e-09	65.0	COG1011@1|root,COG1011@2|Bacteria,1TRP5@1239|Firmicutes,4HBSP@91061|Bacilli,1ZDNA@1386|Bacillus	91061|Bacilli	S	Haloacid dehalogenase-like hydrolase	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2
HKD2_k127_6582145_15	1304284.L21TH_0244	7.996e-20	94.0	COG0681@1|root,COG0681@2|Bacteria,1V2HE@1239|Firmicutes,24R2U@186801|Clostridia,36NAD@31979|Clostridiaceae	186801|Clostridia	U	Peptidase S24-like	-	-	3.4.21.89	ko:K13280	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24
HKD2_k127_6582145_10	398512.JQKC01000007_gene1226	1.682e-73	258.0	COG1305@1|root,COG1305@2|Bacteria,1TP7G@1239|Firmicutes,24BSB@186801|Clostridia,3WM58@541000|Ruminococcaceae	186801|Clostridia	E	Transglutaminase-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Transglut_core
HKD2_k127_6582145_11	268407.PWYN_13535	1.067e-56	203.0	COG2206@1|root,COG2206@2|Bacteria,1UZN2@1239|Firmicutes,4HIY3@91061|Bacilli,2772E@186822|Paenibacillaceae	91061|Bacilli	T	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HD,HD_5
HKD2_k127_6582145_7	398512.JQKC01000022_gene3635	7.102e-106	349.0	COG0476@1|root,COG0476@2|Bacteria,1TQ3U@1239|Firmicutes,25CJC@186801|Clostridia,3WGRI@541000|Ruminococcaceae	186801|Clostridia	H	PFAM UBA THIF-type NAD FAD binding protein	-	-	2.7.7.80	ko:K21029	ko04122,map04122	-	R07459	RC00043	ko00000,ko00001,ko01000	-	-	-	Rhodanese,ThiF
HKD2_k127_6582145_0	1321778.HMPREF1982_04696	1.329e-285	888.0	COG0367@1|root,COG0367@2|Bacteria,1TRPB@1239|Firmicutes,247YA@186801|Clostridia,268P3@186813|unclassified Clostridiales	186801|Clostridia	E	Asparagine synthase	asnB	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
HKD2_k127_6582145_13	635013.TherJR_0965	6.233e-27	117.0	COG1971@1|root,COG1971@2|Bacteria,1V4BC@1239|Firmicutes,24KM0@186801|Clostridia,2625A@186807|Peptococcaceae	186801|Clostridia	P	Probably functions as a manganese efflux pump	ytaF	-	-	-	-	-	-	-	-	-	-	-	Mntp
HKD2_k127_6582145_2	857293.CAAU_1138	5.5e-167	533.0	COG2461@1|root,COG2461@2|Bacteria,1TRD5@1239|Firmicutes,24CKX@186801|Clostridia,36GSW@31979|Clostridiaceae	186801|Clostridia	S	Hemerythrin HHE cation binding domain	-	-	-	ko:K09155	-	-	-	-	ko00000	-	-	-	DUF1858,DUF438,Hemerythrin,PAS_10
HKD2_k127_6582145_14	871963.Desdi_1822	9.263e-26	108.0	COG2461@1|root,COG2461@2|Bacteria,1VGTV@1239|Firmicutes,24SF5@186801|Clostridia,266KG@186807|Peptococcaceae	186801|Clostridia	S	Domain of unknown function (DUF1858)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1858
HKD2_k127_6582145_16	658088.HMPREF0987_02688	2.011e-14	75.0	COG4545@1|root,COG4545@2|Bacteria,1VKJF@1239|Firmicutes,25CSZ@186801|Clostridia,27U6W@186928|unclassified Lachnospiraceae	186801|Clostridia	O	Glutaredoxin-related protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6582145_4	697303.Thewi_0295	8.811e-131	424.0	COG0095@1|root,COG0095@2|Bacteria,1TQ5U@1239|Firmicutes,247S9@186801|Clostridia,42ET4@68295|Thermoanaerobacterales	186801|Clostridia	H	biotin lipoate A B protein ligase	lplJ	-	6.3.1.20	ko:K03800	ko00785,ko01100,map00785,map01100	-	R07770,R07771,R11143	RC00043,RC00070,RC00090,RC00992,RC02896	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB,Lip_prot_lig_C
HKD2_k127_6582145_5	536227.CcarbDRAFT_0263	7.538e-125	405.0	COG0320@1|root,COG0320@2|Bacteria,1TQM4@1239|Firmicutes,2495Q@186801|Clostridia,36FJZ@31979|Clostridiaceae	186801|Clostridia	H	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives	lipA	-	2.8.1.8	ko:K03644	ko00785,ko01100,map00785,map01100	-	R07767,R07768	RC01978	ko00000,ko00001,ko01000	-	-	-	LIAS_N,Radical_SAM
HKD2_k127_6582145_8	1408422.JHYF01000010_gene3323	6.05e-88	295.0	COG0321@1|root,COG0321@2|Bacteria,1V44P@1239|Firmicutes,24GE9@186801|Clostridia,36HGP@31979|Clostridiaceae	186801|Clostridia	H	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate	lipB	-	2.3.1.181	ko:K03801	ko00785,ko01100,map00785,map01100	-	R07766,R07769	RC00039,RC00992,RC02867	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB
HKD2_k127_6582145_6	1304284.L21TH_0731	1.943e-106	352.0	COG1760@1|root,COG1760@2|Bacteria,1TP79@1239|Firmicutes,2480J@186801|Clostridia,36DCQ@31979|Clostridiaceae	186801|Clostridia	E	L-serine dehydratase, iron-sulfur-dependent, alpha subunit	sdaAA	-	4.3.1.17	ko:K01752	ko00260,ko00270,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00270,map01100,map01110,map01130,map01200,map01230	-	R00220,R00590	RC00331,RC02600	ko00000,ko00001,ko01000	-	-	-	SDH_alpha
HKD2_k127_6582145_9	941824.TCEL_01482	8.355e-77	263.0	COG1760@1|root,COG1760@2|Bacteria,1U8TZ@1239|Firmicutes,24AEE@186801|Clostridia,36EDV@31979|Clostridiaceae	186801|Clostridia	E	L-serine dehydratase, iron-sulfur-dependent, beta subunit	sdaAB	-	4.3.1.17	ko:K01752	ko00260,ko00270,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00270,map01100,map01110,map01130,map01200,map01230	-	R00220,R00590	RC00331,RC02600	ko00000,ko00001,ko01000	-	-	-	ACT,SDH_beta
HKD2_k127_6582145_1	1321778.HMPREF1982_00244	4.184e-178	563.0	COG0404@1|root,COG0404@2|Bacteria,1TRKX@1239|Firmicutes,248U7@186801|Clostridia,268C7@186813|unclassified Clostridiales	186801|Clostridia	E	The glycine cleavage system catalyzes the degradation of glycine	gcvT	-	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	GCV_T,GCV_T_C
HKD2_k127_6582145_12	1321778.HMPREF1982_00245	4.759e-50	181.0	COG0509@1|root,COG0509@2|Bacteria,1V6WV@1239|Firmicutes,24N5H@186801|Clostridia,269BB@186813|unclassified Clostridiales	186801|Clostridia	E	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	gcvH	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
HKD2_k127_6582145_3	1321778.HMPREF1982_00246	2.806e-158	505.0	COG0403@1|root,COG0403@2|Bacteria,1TQGG@1239|Firmicutes,2492A@186801|Clostridia,268QF@186813|unclassified Clostridiales	186801|Clostridia	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPA	-	1.4.4.2	ko:K00282	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	-	GDC-P
HKD2_k127_6588126_1	1321778.HMPREF1982_00209	3.007e-143	467.0	COG0659@1|root,COG0659@2|Bacteria,1TPI4@1239|Firmicutes,24978@186801|Clostridia,268H8@186813|unclassified Clostridiales	186801|Clostridia	P	Sulfate permease family	-	-	-	ko:K03321	-	-	-	-	ko00000,ko02000	2.A.53.3	-	-	STAS,Sulfate_transp
HKD2_k127_6588126_3	632292.Calhy_0230	1.806e-103	351.0	COG4690@1|root,COG4690@2|Bacteria,1V44V@1239|Firmicutes	1239|Firmicutes	E	Peptidase family C69	-	-	-	ko:K14358	-	-	-	-	ko00000,ko01002	-	-	-	Peptidase_C69
HKD2_k127_6588126_0	649747.HMPREF0083_01523	4.718e-245	764.0	COG0397@1|root,COG0397@2|Bacteria,1TQXD@1239|Firmicutes,4HBKH@91061|Bacilli,26U17@186822|Paenibacillaceae	91061|Bacilli	S	Belongs to the UPF0061 (SELO) family	M1-1044	-	-	-	-	-	-	-	-	-	-	-	UPF0061
HKD2_k127_6588126_5	1121334.KB911069_gene1530	2.808e-39	156.0	COG1131@1|root,COG1131@2|Bacteria,1VF25@1239|Firmicutes,248Y7@186801|Clostridia,3WJWF@541000|Ruminococcaceae	186801|Clostridia	V	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6588126_2	509191.AEDB02000020_gene3396	4.668e-122	394.0	COG1131@1|root,COG1131@2|Bacteria,1TPUP@1239|Firmicutes,249FR@186801|Clostridia,3WI2X@541000|Ruminococcaceae	186801|Clostridia	V	Psort location CytoplasmicMembrane, score	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD2_k127_6588126_4	768710.DesyoDRAFT_4190	4.543e-48	175.0	COG1725@1|root,COG1725@2|Bacteria,1VA2B@1239|Firmicutes,24N57@186801|Clostridia,26324@186807|Peptococcaceae	186801|Clostridia	K	PFAM Bacterial regulatory proteins, gntR family	-	-	-	-	-	-	-	-	-	-	-	-	GntR
HKD2_k127_6588126_6	1128398.Curi_c11550	3.196e-06	50.0	COG5012@1|root,COG5012@2|Bacteria,1V1P0@1239|Firmicutes,24G08@186801|Clostridia,26B33@186813|unclassified Clostridiales	186801|Clostridia	S	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,B12-binding_2
HKD2_k127_6596158_6	1476973.JMMB01000007_gene1011	1.851e-115	383.0	COG0552@1|root,COG0552@2|Bacteria,1TPRI@1239|Firmicutes,247JD@186801|Clostridia,25R1C@186804|Peptostreptococcaceae	186801|Clostridia	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)	ftsY	-	-	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2,3.A.5.7	-	-	SRP54,SRP54_N
HKD2_k127_6596158_0	1121289.JHVL01000003_gene2254	1.415e-253	823.0	COG1196@1|root,COG1196@2|Bacteria,1TPJV@1239|Firmicutes,249F4@186801|Clostridia,36ECC@31979|Clostridiaceae	186801|Clostridia	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
HKD2_k127_6596158_11	1321778.HMPREF1982_02040	2.105e-37	142.0	COG2359@1|root,COG2359@2|Bacteria,1VA4R@1239|Firmicutes,25CX3@186801|Clostridia	186801|Clostridia	S	stage V sporulation protein S	-	-	-	ko:K06416	-	-	-	-	ko00000	-	-	-	SpoVS
HKD2_k127_6596158_7	1121289.JHVL01000003_gene2255	1.287e-106	356.0	COG1243@1|root,COG1243@2|Bacteria,1TS1F@1239|Firmicutes,248YV@186801|Clostridia,36DYS@31979|Clostridiaceae	186801|Clostridia	BK	Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Fer4_14,Radical_SAM,Radical_SAM_C
HKD2_k127_6596158_9	350688.Clos_1458	2.298e-74	258.0	COG0571@1|root,COG0571@2|Bacteria,1TPGC@1239|Firmicutes,249QD@186801|Clostridia,36FEP@31979|Clostridiaceae	186801|Clostridia	J	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism	rnc	-	3.1.26.3	ko:K03685	ko03008,ko05205,map03008,map05205	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019,ko03036	-	-	-	Ribonucleas_3_3,dsrm
HKD2_k127_6596158_1	1449126.JQKL01000022_gene140	3.828e-185	586.0	COG0304@1|root,COG0304@2|Bacteria,1TPA7@1239|Firmicutes,247VF@186801|Clostridia,267N3@186813|unclassified Clostridiales	186801|Clostridia	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	fabF	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
HKD2_k127_6596158_12	340099.Teth39_1286	5.539e-28	114.0	COG0236@1|root,COG0236@2|Bacteria,1VEE3@1239|Firmicutes,24QME@186801|Clostridia,42H5S@68295|Thermoanaerobacterales	186801|Clostridia	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	acpP	-	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
HKD2_k127_6596158_8	1414720.CBYM010000027_gene2270	2.25e-96	321.0	COG1028@1|root,COG1028@2|Bacteria,1TP76@1239|Firmicutes,247PV@186801|Clostridia,36EGR@31979|Clostridiaceae	186801|Clostridia	IQ	reductase	fabG	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HKD2_k127_6596158_5	203119.Cthe_0935	3.488e-122	399.0	COG0331@1|root,COG0331@2|Bacteria,1TPB7@1239|Firmicutes,247UF@186801|Clostridia,3WGWD@541000|Ruminococcaceae	186801|Clostridia	I	malonyl CoA-acyl carrier protein transacylase	fabD	-	2.3.1.39	ko:K00645	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	M00082	R01626,R11671	RC00004,RC00039,RC02727	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyl_transf_1
HKD2_k127_6596158_2	935948.KE386495_gene1798	6.668e-143	458.0	COG2070@1|root,COG2070@2|Bacteria,1TPC3@1239|Firmicutes,24831@186801|Clostridia,42F3W@68295|Thermoanaerobacterales	186801|Clostridia	S	enoyl-(acyl-carrier-protein) reductase II	fabK	-	1.3.1.9	ko:K02371	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00083	R04429,R04724,R04955,R04958,R04961,R04966,R04969,R07765	RC00052,RC00076	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	iHN637.CLJU_RS20775	NMO
HKD2_k127_6596158_3	697303.Thewi_1430	1.27e-136	442.0	COG0332@1|root,COG0332@2|Bacteria,1TP0K@1239|Firmicutes,248V8@186801|Clostridia,42ER1@68295|Thermoanaerobacterales	186801|Clostridia	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	fabH	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
HKD2_k127_6596158_4	1121289.JHVL01000003_gene2263	2.259e-123	404.0	COG0416@1|root,COG0416@2|Bacteria,1TPXS@1239|Firmicutes,247KW@186801|Clostridia,36E96@31979|Clostridiaceae	186801|Clostridia	I	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA	plsX	-	2.3.1.15	ko:K03621	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FA_synthesis
HKD2_k127_6596158_10	1121289.JHVL01000003_gene2264	2.825e-73	251.0	COG2050@1|root,COG2050@2|Bacteria,1UIJX@1239|Firmicutes,25F1A@186801|Clostridia,36I5S@31979|Clostridiaceae	186801|Clostridia	K	Thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT,HTH_DeoR,MaoC_dehydratas
HKD2_k127_6596158_13	1304284.L21TH_1393	1.042e-10	61.0	COG0333@1|root,COG0333@2|Bacteria,1VEFI@1239|Firmicutes,24QM0@186801|Clostridia,36MII@31979|Clostridiaceae	186801|Clostridia	J	Belongs to the bacterial ribosomal protein bL32 family	rpmF	-	-	ko:K02911	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_L32p
HKD2_k127_6603469_4	293826.Amet_0148	5.289e-73	250.0	COG2195@1|root,COG2195@2|Bacteria,1TP3A@1239|Firmicutes,248JJ@186801|Clostridia,36EEA@31979|Clostridiaceae	186801|Clostridia	E	Cleaves the N-terminal amino acid of tripeptides	-	-	3.4.11.4	ko:K01258	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
HKD2_k127_6603469_3	1131462.DCF50_p293	1.164e-87	298.0	COG0190@1|root,COG0190@2|Bacteria,1TP1P@1239|Firmicutes,248DB@186801|Clostridia,2606K@186807|Peptococcaceae	186801|Clostridia	F	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate	folD	-	1.5.1.5,3.5.4.9	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R01220,R01655	RC00202,RC00578	ko00000,ko00001,ko00002,ko01000	-	-	-	THF_DHG_CYH,THF_DHG_CYH_C
HKD2_k127_6603469_5	580331.Thit_0289	1.018e-72	256.0	COG0524@1|root,COG2771@1|root,COG0524@2|Bacteria,COG2771@2|Bacteria,1TQR4@1239|Firmicutes,24AUP@186801|Clostridia,42EVE@68295|Thermoanaerobacterales	186801|Clostridia	H	PFAM PfkB domain protein	rbsK	-	2.7.1.15,2.7.1.83	ko:K00852,ko:K16328	ko00030,ko00240,map00030,map00240	-	R01051,R02750,R03315	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	HTH_24,PfkB
HKD2_k127_6603469_0	1117379.BABA_20231	2.52e-152	488.0	COG0182@1|root,COG0182@2|Bacteria,1TPDK@1239|Firmicutes,4H9WM@91061|Bacilli,1ZCD9@1386|Bacillus	91061|Bacilli	E	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)	mtnA	-	5.3.1.23	ko:K08963	ko00270,ko01100,map00270,map01100	M00034	R04420	RC01151	ko00000,ko00001,ko00002,ko01000	-	-	-	IF-2B
HKD2_k127_6603469_1	1031288.AXAA01000026_gene247	7.065e-124	403.0	COG2313@1|root,COG2313@2|Bacteria,1TR5J@1239|Firmicutes,247J8@186801|Clostridia,36F77@31979|Clostridiaceae	186801|Clostridia	Q	Catalyzes the reversible cleavage of pseudouridine 5'- phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway	psuG	-	4.2.1.70	ko:K16329	ko00240,map00240	-	R01055	RC00432,RC00433	ko00000,ko00001,ko01000	-	-	-	Indigoidine_A
HKD2_k127_6603469_6	1121335.Clst_2110	1.363e-46	183.0	COG2199@1|root,COG3706@2|Bacteria,1TQIK@1239|Firmicutes,249Y6@186801|Clostridia	186801|Clostridia	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,GGDEF,TPR_12,TPR_8
HKD2_k127_6603469_2	755731.Clo1100_1208	5.307e-108	355.0	COG4108@1|root,COG4108@2|Bacteria,1TPYT@1239|Firmicutes,247X3@186801|Clostridia,36DUQ@31979|Clostridiaceae	186801|Clostridia	J	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP	prfC	-	-	ko:K02837	-	-	-	-	ko00000,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,RF3_C
HKD2_k127_6603602_1	1120746.CCNL01000017_gene2537	5.803e-142	452.0	28HT7@1|root,2Z804@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6603602_5	1120746.CCNL01000017_gene2538	2.084e-21	93.0	COG1148@1|root,COG1148@2|Bacteria	2|Bacteria	C	4fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer2_BFD,Fer4
HKD2_k127_6603602_4	994573.T472_0205880	1.766e-71	244.0	COG1148@1|root,COG1148@2|Bacteria,1TRUH@1239|Firmicutes,24A9X@186801|Clostridia	186801|Clostridia	C	BFD-like 2Fe-2S binding	-	-	-	-	-	-	-	-	-	-	-	-	Fer2_BFD,Fer4
HKD2_k127_6603602_0	1120746.CCNL01000017_gene2539	2.721e-170	539.0	COG0119@1|root,COG0119@2|Bacteria	2|Bacteria	E	Belongs to the alpha-IPM synthase homocitrate synthase family	mhpE	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0008701,GO:0016829,GO:0016830,GO:0016833,GO:0030312,GO:0044464,GO:0071944	4.1.3.39,4.1.3.43	ko:K01666,ko:K18365	ko00360,ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00360,map00362,map00621,map00622,map01100,map01120,map01220	M00545,M00569	R00750,R05298	RC00307,RC00371,RC00572	br01602,ko00000,ko00001,ko00002,ko01000	-	-	iECIAI39_1322.ECIAI39_0326,iEcSMS35_1347.EcSMS35_0383,iYL1228.KPN_02117	DmpG_comm,HMGL-like
HKD2_k127_6603602_2	768706.Desor_0612	8.281e-142	454.0	COG4569@1|root,COG4569@2|Bacteria,1TQJS@1239|Firmicutes,248JS@186801|Clostridia,26114@186807|Peptococcaceae	186801|Clostridia	Q	Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD( ) and coenzyme A. Is the final enzyme in the meta- cleavage pathway for the degradation of aromatic compounds	mhpF	-	1.2.1.10	ko:K04073	ko00360,ko00362,ko00620,ko00621,ko00622,ko00650,ko01100,ko01120,ko01220,map00360,map00362,map00620,map00621,map00622,map00650,map01100,map01120,map01220	M00545,M00569	R00228,R01172	RC00004,RC00184,RC01195	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	AcetDehyd-dimer,Semialdhyde_dh
HKD2_k127_6603602_3	1009370.ALO_08355	1.411e-95	315.0	COG3971@1|root,COG3971@2|Bacteria,1TQVG@1239|Firmicutes,4H793@909932|Negativicutes	909932|Negativicutes	Q	Fumarylacetoacetate (FAA) hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	FAA_hydrolase
HKD2_k127_6644033_5	536227.CcarbDRAFT_4989	3.149e-79	270.0	COG0642@1|root,COG2205@2|Bacteria,1TQMV@1239|Firmicutes,247SE@186801|Clostridia,36ERF@31979|Clostridiaceae	186801|Clostridia	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,MASE3,PAS_3,PAS_8,PAS_9,Response_reg
HKD2_k127_6644033_2	1408422.JHYF01000007_gene1332	1.5e-171	554.0	COG3290@1|root,COG3290@2|Bacteria,1TQJR@1239|Firmicutes,247YE@186801|Clostridia,36EQS@31979|Clostridiaceae	186801|Clostridia	T	signal transduction histidine kinase regulating citrate malate metabolism	citS	-	2.7.13.3	ko:K02476,ko:K11614,ko:K11691	ko02020,map02020	M00489,M00490	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HATPase_c_5,PAS,PAS_10,PAS_8,PAS_9,SPOB_a,sCache_3_2
HKD2_k127_6644033_4	1499689.CCNN01000014_gene3238	3.488e-93	310.0	COG4565@1|root,COG4565@2|Bacteria,1V49R@1239|Firmicutes,24BJS@186801|Clostridia,36HG7@31979|Clostridiaceae	186801|Clostridia	KT	transcriptional regulatory protein	dctR	-	-	ko:K02475,ko:K11615,ko:K11692,ko:K11712	ko02020,map02020	M00489,M00490	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_11,Response_reg
HKD2_k127_6644033_1	293826.Amet_1304	1.035e-188	595.0	COG0281@1|root,COG0281@2|Bacteria,1TPJ3@1239|Firmicutes,2487U@186801|Clostridia,36DTC@31979|Clostridiaceae	186801|Clostridia	C	malic enzyme	-	-	1.1.1.38	ko:K00027	ko00620,ko01200,ko02020,map00620,map01200,map02020	-	R00214	RC00105	ko00000,ko00001,ko01000	-	-	-	Malic_M,malic
HKD2_k127_6644033_0	1499689.CCNN01000014_gene3239	1.368e-214	673.0	COG3493@1|root,COG3493@2|Bacteria,1TR97@1239|Firmicutes,24BDA@186801|Clostridia,36GMZ@31979|Clostridiaceae	186801|Clostridia	C	2-hydroxycarboxylate transporter family	citP	-	-	ko:K11616	ko02020,map02020	-	-	-	ko00000,ko00001	2.A.24.2	-	-	2HCT
HKD2_k127_6644033_3	293826.Amet_2963	3.443e-136	436.0	COG0065@1|root,COG0065@2|Bacteria,1TPE5@1239|Firmicutes,2484F@186801|Clostridia,36VB5@31979|Clostridiaceae	186801|Clostridia	H	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	-	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
HKD2_k127_6663192_4	720554.Clocl_1750	7.075e-17	81.0	2DMEN@1|root,32R0Q@2|Bacteria,1V71M@1239|Firmicutes,24KBN@186801|Clostridia,3WJR1@541000|Ruminococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	TadE
HKD2_k127_6663192_0	509191.AEDB02000003_gene1054	4.803e-80	295.0	2BXNJ@1|root,2ZC8M@2|Bacteria,1UYM5@1239|Firmicutes,24ASZ@186801|Clostridia,3WKGX@541000|Ruminococcaceae	186801|Clostridia	S	Psort location	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6663192_5	720554.Clocl_1748	1.257e-16	88.0	2DPM4@1|root,332KY@2|Bacteria,1VHK3@1239|Firmicutes,24KVK@186801|Clostridia,3WJI0@541000|Ruminococcaceae	186801|Clostridia	S	Pilus assembly protein TadE	-	-	-	-	-	-	-	-	-	-	-	-	TadE
HKD2_k127_6663192_1	509191.AEDB02000065_gene716	8.736e-76	263.0	COG2064@1|root,COG2064@2|Bacteria,1V2C3@1239|Firmicutes,24AN4@186801|Clostridia,3WJSN@541000|Ruminococcaceae	186801|Clostridia	NU	Type II secretion system	-	-	-	ko:K12511	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
HKD2_k127_6663192_2	203119.Cthe_1338	6.296e-70	246.0	COG4965@1|root,COG4965@2|Bacteria,1V6PB@1239|Firmicutes,24JBR@186801|Clostridia,3WJUZ@541000|Ruminococcaceae	186801|Clostridia	U	Flp pilus assembly protein TadB	tadB	-	-	ko:K12510	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
HKD2_k127_6663192_3	1410638.JHXJ01000021_gene2386	7.984e-28	113.0	COG4962@1|root,COG4962@2|Bacteria,1TQ0Z@1239|Firmicutes,249VS@186801|Clostridia,3WGJJ@541000|Ruminococcaceae	186801|Clostridia	U	Type II IV secretion system protein	-	-	-	ko:K02283	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
HKD2_k127_6668596_0	1211817.CCAT010000023_gene2853	9.363e-197	615.0	COG0008@1|root,COG0008@2|Bacteria,1TP8G@1239|Firmicutes,247Y0@186801|Clostridia,36ENJ@31979|Clostridiaceae	186801|Clostridia	J	Glutaminyl-tRNA synthetase	glnS	-	6.1.1.18	ko:K01886	ko00970,ko01100,map00970,map01100	M00359,M00360	R03652	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1c,tRNA-synt_1c_C
HKD2_k127_6668596_1	871968.DESME_06940	1.494e-142	460.0	COG0477@1|root,COG2814@2|Bacteria,1UY64@1239|Firmicutes,249MW@186801|Clostridia,2615G@186807|Peptococcaceae	186801|Clostridia	EGP	major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD2_k127_6668669_11	1321778.HMPREF1982_04502	1.945e-26	109.0	COG0031@1|root,COG0031@2|Bacteria,1TZEW@1239|Firmicutes,249RW@186801|Clostridia,267P0@186813|unclassified Clostridiales	186801|Clostridia	E	Pyridoxal-phosphate dependent enzyme	-	-	-	-	-	-	-	-	-	-	-	-	PALP
HKD2_k127_6668669_3	1321778.HMPREF1982_04503	3.082e-172	548.0	COG0498@1|root,COG0498@2|Bacteria,1TP25@1239|Firmicutes,25B08@186801|Clostridia,2686W@186813|unclassified Clostridiales	186801|Clostridia	E	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine	-	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HKD2_k127_6668669_4	1443122.Z958_12780	2.049e-168	540.0	COG0402@1|root,COG0402@2|Bacteria,1TP43@1239|Firmicutes,248IX@186801|Clostridia,36FIQ@31979|Clostridiaceae	186801|Clostridia	F	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine	ssnA	-	3.5.4.40	ko:K20810	ko00130,ko01110,map00130,map01110	-	R10695	RC00477	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
HKD2_k127_6668669_2	1487921.DP68_16205	1.615e-172	546.0	COG0167@1|root,COG1145@1|root,COG0167@2|Bacteria,COG1145@2|Bacteria,1TRPI@1239|Firmicutes,24A0Z@186801|Clostridia,36EA4@31979|Clostridiaceae	186801|Clostridia	C	dihydroorotate dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	DHO_dh,Fer4
HKD2_k127_6668669_6	1443122.Z958_12790	4.12e-77	266.0	COG1319@1|root,COG1319@2|Bacteria,1TSNH@1239|Firmicutes,24A57@186801|Clostridia,36EPQ@31979|Clostridiaceae	186801|Clostridia	C	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM	xdhB	-	-	-	-	-	-	-	-	-	-	-	CO_deh_flav_C,FAD_binding_5
HKD2_k127_6668669_8	1487921.DP68_16215	3.615e-59	209.0	COG2080@1|root,COG2080@2|Bacteria,1V6HE@1239|Firmicutes,24HQN@186801|Clostridia,36I5I@31979|Clostridiaceae	186801|Clostridia	C	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS	hcrC	-	1.2.5.3	ko:K03518	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Fer2,Fer2_2
HKD2_k127_6668669_0	1487921.DP68_16220	0.0	1143.0	COG1529@1|root,COG1529@2|Bacteria,1TP7U@1239|Firmicutes,248BV@186801|Clostridia,36DY8@31979|Clostridiaceae	186801|Clostridia	C	aldehyde oxidase and xanthine dehydrogenase, a b hammerhead	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
HKD2_k127_6668669_7	1443122.Z958_12805	9.615e-67	232.0	COG2068@1|root,COG2068@2|Bacteria,1UY6E@1239|Firmicutes,249PV@186801|Clostridia,36FU4@31979|Clostridiaceae	186801|Clostridia	S	MobA-like NTP transferase domain	-	-	2.7.7.76	ko:K07141	ko00790,map00790	-	R11582	-	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
HKD2_k127_6668669_1	1487921.DP68_16230	2.077e-291	910.0	COG1529@1|root,COG1529@2|Bacteria,1TP7U@1239|Firmicutes,248BV@186801|Clostridia,36DY8@31979|Clostridiaceae	186801|Clostridia	C	aldehyde oxidase and xanthine dehydrogenase, a b hammerhead	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
HKD2_k127_6668669_9	656519.Halsa_2103	9.051e-52	187.0	COG2080@1|root,COG2080@2|Bacteria,1V6HE@1239|Firmicutes,24J9B@186801|Clostridia,3WBQ7@53433|Halanaerobiales	186801|Clostridia	C	[2Fe-2S] binding domain	-	-	1.17.1.5,1.2.5.3	ko:K03518,ko:K20446	ko00760,ko01120,map00760,map01120	-	R01720,R11168	RC00589,RC02800	ko00000,ko00001,ko01000	-	-	-	Fer2,Fer2_2
HKD2_k127_6668669_5	1294142.CINTURNW_3680	1.018e-83	286.0	COG1319@1|root,COG1319@2|Bacteria,1UZF3@1239|Firmicutes,25BBI@186801|Clostridia,36WC4@31979|Clostridiaceae	186801|Clostridia	C	molybdopterin dehydrogenase, FAD-binding	-	-	-	-	-	-	-	-	-	-	-	-	CO_deh_flav_C,FAD_binding_5
HKD2_k127_6668669_10	1262449.CP6013_2856	2.757e-47	173.0	COG0044@1|root,COG0044@2|Bacteria,1TP8C@1239|Firmicutes,249W6@186801|Clostridia,36EQM@31979|Clostridiaceae	186801|Clostridia	F	PFAM amidohydrolase	hydA	-	3.5.2.2	ko:K01464	ko00240,ko00410,ko00770,ko00983,ko01100,map00240,map00410,map00770,map00983,map01100	M00046	R02269,R03055,R08227	RC00632,RC00680	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Amidohydro_1
HKD2_k127_6684207_7	1209989.TepiRe1_2839	1.085e-36	144.0	COG1943@1|root,COG1943@2|Bacteria,1VCIB@1239|Firmicutes,24MZS@186801|Clostridia	186801|Clostridia	L	Transposase IS200 like	-	-	-	-	-	-	-	-	-	-	-	-	Y1_Tnp
HKD2_k127_6684207_4	697281.Mahau_0247	2.74e-81	278.0	COG0428@1|root,COG0428@2|Bacteria,1TP7J@1239|Firmicutes,247Q2@186801|Clostridia,42G5W@68295|Thermoanaerobacterales	186801|Clostridia	P	PFAM Zinc iron permease	-	-	-	ko:K07238	-	-	-	-	ko00000,ko02000	2.A.5.5	-	-	Zip
HKD2_k127_6684207_1	350688.Clos_2575	6.064e-111	369.0	COG0009@1|root,COG0009@2|Bacteria,1TP1I@1239|Firmicutes,248HS@186801|Clostridia,36EVH@31979|Clostridiaceae	186801|Clostridia	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine	sua	-	2.7.7.87	ko:K07566	-	-	R10463	RC00745	ko00000,ko01000,ko03009,ko03016	-	-	-	SUA5,Sua5_yciO_yrdC
HKD2_k127_6684207_8	349161.Dred_3164	1.026e-32	132.0	COG0394@1|root,COG0394@2|Bacteria,1VA05@1239|Firmicutes,25CRM@186801|Clostridia,262N5@186807|Peptococcaceae	186801|Clostridia	T	Low molecular weight phosphotyrosine protein phosphatase	ywlE	-	3.1.3.48,3.9.1.2	ko:K01104,ko:K20201	-	-	-	-	ko00000,ko01000	-	-	-	LMWPc
HKD2_k127_6684207_5	350688.Clos_2573	2.33e-64	223.0	COG0698@1|root,COG0698@2|Bacteria,1V3HE@1239|Firmicutes,24JWT@186801|Clostridia,36I0M@31979|Clostridiaceae	186801|Clostridia	G	Ribose 5-phosphate isomerase	rpiB	-	5.3.1.6	ko:K01808	ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01056,R09030	RC00376,RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	LacAB_rpiB
HKD2_k127_6684207_2	580327.Tthe_2529	4.767e-108	352.0	COG0035@1|root,COG0035@2|Bacteria,1TPMT@1239|Firmicutes,248FV@186801|Clostridia,42FSE@68295|Thermoanaerobacterales	186801|Clostridia	F	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate	upp	-	2.4.2.9	ko:K00761	ko00240,ko01100,map00240,map01100	-	R00966	RC00063	ko00000,ko00001,ko01000	-	-	-	UPRTase
HKD2_k127_6684207_6	1094508.Tsac_0315	2.947e-64	223.0	COG2131@1|root,COG2131@2|Bacteria,1V3PU@1239|Firmicutes,24HF0@186801|Clostridia,42GBV@68295|Thermoanaerobacterales	186801|Clostridia	F	PFAM CMP dCMP deaminase zinc-binding	comEB	-	3.5.4.12	ko:K01493	ko00240,ko01100,map00240,map01100	M00429	R01663	RC00074	ko00000,ko00001,ko00002,ko01000,ko02044	-	-	-	dCMP_cyt_deam_1
HKD2_k127_6684207_3	1123511.KB905854_gene3640	3.728e-95	323.0	COG0472@1|root,COG0472@2|Bacteria,1TP9V@1239|Firmicutes,4H2U9@909932|Negativicutes	909932|Negativicutes	M	Glycosyltransferase, group 4 family	tagO	-	2.7.8.33,2.7.8.35	ko:K02851	-	-	R08856	RC00002	ko00000,ko01000,ko01003,ko01005	-	-	-	Glycos_transf_4
HKD2_k127_6684207_0	642492.Clole_3629	1.166e-150	482.0	COG0381@1|root,COG0381@2|Bacteria,1TQZT@1239|Firmicutes,247N7@186801|Clostridia	186801|Clostridia	M	Belongs to the UDP-N-acetylglucosamine 2-epimerase family	-	-	2.7.8.33,2.7.8.35,5.1.3.14	ko:K01791,ko:K02851	ko00520,ko01100,ko05111,map00520,map01100,map05111	M00362	R00420,R08856	RC00002,RC00290	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	-	-	Epimerase_2,Glycos_transf_4
HKD2_k127_6688129_0	1122915.AUGY01000054_gene69	3.932e-173	558.0	COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1UCUQ@1239|Firmicutes,4HC5Q@91061|Bacilli,26QMW@186822|Paenibacillaceae	91061|Bacilli	T	PFAM response regulator receiver	-	-	-	ko:K07720	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_18,Response_reg
HKD2_k127_6688129_1	1122915.AUGY01000054_gene68	3.153e-126	412.0	COG2972@1|root,COG2972@2|Bacteria,1U6WN@1239|Firmicutes,4HASD@91061|Bacilli,274BU@186822|Paenibacillaceae	91061|Bacilli	T	Histidine kinase	-	-	2.7.13.3	ko:K07718	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,His_kinase
HKD2_k127_6697312_1	1321778.HMPREF1982_00037	1.079e-217	681.0	COG0534@1|root,COG0534@2|Bacteria,1TNZN@1239|Firmicutes,247YX@186801|Clostridia,268UX@186813|unclassified Clostridiales	186801|Clostridia	V	Polysaccharide biosynthesis C-terminal domain	mepA_10	-	-	-	-	-	-	-	-	-	-	-	MatE
HKD2_k127_6697312_7	332101.JIBU02000009_gene801	1.218e-94	317.0	COG4866@1|root,COG4866@2|Bacteria,1URPS@1239|Firmicutes,24XIU@186801|Clostridia,36RB0@31979|Clostridiaceae	186801|Clostridia	S	Uncharacterised conserved protein (DUF2156)	-	-	-	ko:K01163	-	-	-	-	ko00000	-	-	-	DUF2156
HKD2_k127_6697312_10	519442.Huta_0481	4.489e-61	223.0	COG3919@1|root,arCOG06897@2157|Archaea,2XVV0@28890|Euryarchaeota	28890|Euryarchaeota	S	COG0458 Carbamoylphosphate synthase large subunit (split gene in MJ)	-	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	ATPgrasp_Ter
HKD2_k127_6697312_6	755731.Clo1100_3301	3.039e-118	385.0	COG2996@1|root,COG2996@2|Bacteria,1TQ1Z@1239|Firmicutes,2498C@186801|Clostridia,36EB0@31979|Clostridiaceae	186801|Clostridia	S	S1, RNA binding domain	cvfB	-	-	ko:K00243	-	-	-	-	ko00000	-	-	-	S1,S1_2
HKD2_k127_6697312_9	696281.Desru_3235	3.697e-64	224.0	COG1528@1|root,COG1528@2|Bacteria,1V1BJ@1239|Firmicutes,24FUF@186801|Clostridia,262IN@186807|Peptococcaceae	186801|Clostridia	P	Iron-storage protein	ftnA	-	1.16.3.2	ko:K02217	-	-	-	-	ko00000,ko01000	-	-	-	Ferritin
HKD2_k127_6697312_2	1118054.CAGW01000017_gene4331	1.627e-175	572.0	COG3829@1|root,COG3829@2|Bacteria,1TP0E@1239|Firmicutes,4HADT@91061|Bacilli,272D8@186822|Paenibacillaceae	91061|Bacilli	K	Sigma-54 interaction domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_12,HTH_8,PAS,Sigma54_activat
HKD2_k127_6697312_0	411902.CLOBOL_04038	1.302e-272	848.0	COG1288@1|root,COG1288@2|Bacteria,1TQJ0@1239|Firmicutes,248UK@186801|Clostridia,222HP@1506553|Lachnoclostridium	186801|Clostridia	S	C4-dicarboxylate anaerobic carrier	-	-	-	-	-	-	-	-	-	-	-	-	DcuC
HKD2_k127_6697312_3	1033744.CAEL01000024_gene1694	4.285e-168	536.0	COG0044@1|root,COG0044@2|Bacteria,1TPI6@1239|Firmicutes,2495I@186801|Clostridia,22GJ2@1570339|Peptoniphilaceae	186801|Clostridia	F	Catalyzes the hydrolytic cleavage of a subset of L- isoaspartyl (L-beta-aspartyl) dipeptides. Used to degrade proteins damaged by L-isoaspartyl residues formation	iadA	-	-	ko:K01305	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Amidohydro_1,Amidohydro_3
HKD2_k127_6697312_11	1121289.JHVL01000004_gene2079	6.544e-51	187.0	COG1408@1|root,COG1408@2|Bacteria,1UN2Z@1239|Firmicutes,25GVP@186801|Clostridia,36V5S@31979|Clostridiaceae	186801|Clostridia	S	Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
HKD2_k127_6697312_8	1410668.JNKC01000001_gene1729	1.268e-83	289.0	arCOG05878@1|root,2ZC5B@2|Bacteria,1V210@1239|Firmicutes,24GVY@186801|Clostridia,36JCV@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6697312_4	1499689.CCNN01000014_gene3234	3.451e-134	432.0	COG2267@1|root,COG2267@2|Bacteria,1TPI0@1239|Firmicutes,247QR@186801|Clostridia,36F4I@31979|Clostridiaceae	186801|Clostridia	I	Alpha beta hydrolase	-	-	1.11.1.10,3.1.1.24	ko:K00433,ko:K01055	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00568	R02991	RC00825	ko00000,ko00001,ko00002,ko01000	-	-	-	Abhydrolase_1,Abhydrolase_4
HKD2_k127_6697312_5	1487921.DP68_10580	5.924e-123	398.0	COG2323@1|root,COG2323@2|Bacteria,1TRWQ@1239|Firmicutes,24CFP@186801|Clostridia,36EE2@31979|Clostridiaceae	186801|Clostridia	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF421
HKD2_k127_6697312_12	1487921.DP68_10575	1.899e-45	167.0	2E3DS@1|root,32YCW@2|Bacteria,1VG0X@1239|Firmicutes,24KWA@186801|Clostridia,36JPJ@31979|Clostridiaceae	186801|Clostridia	S	Domain of unknown function (DUF4363)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4363
HKD2_k127_6701457_1	350688.Clos_1997	7.713e-47	169.0	COG0251@1|root,COG0251@2|Bacteria,1VVJ9@1239|Firmicutes,24G4V@186801|Clostridia,36I89@31979|Clostridiaceae	186801|Clostridia	J	Endoribonuclease L-PSP	-	-	-	-	-	-	-	-	-	-	-	-	Ribonuc_L-PSP
HKD2_k127_6701457_0	2325.TKV_c11970	1.946e-105	351.0	COG3854@1|root,COG3854@2|Bacteria,1TQ23@1239|Firmicutes,248S2@186801|Clostridia,42ERU@68295|Thermoanaerobacterales	186801|Clostridia	S	SMART AAA ATPase	spoIIIAA	-	-	ko:K06390	-	-	-	-	ko00000	-	-	-	T2SSE
HKD2_k127_6701457_3	1157490.EL26_14980	3.617e-35	140.0	2CEWW@1|root,32S0Q@2|Bacteria,1VAEG@1239|Firmicutes,4HGSK@91061|Bacilli,278N0@186823|Alicyclobacillaceae	91061|Bacilli	S	Stage III sporulation protein AB (spore_III_AB)	spoIIIAB	-	-	ko:K06391	-	-	-	-	ko00000	-	-	-	Spore_III_AB
HKD2_k127_6701457_4	697281.Mahau_0775	7.161e-19	87.0	2E555@1|root,32ZY3@2|Bacteria,1VEM4@1239|Firmicutes,24QNR@186801|Clostridia,42H32@68295|Thermoanaerobacterales	186801|Clostridia	S	TIGRFAM stage III sporulation protein AC	spoIIIAC	-	-	ko:K06392	-	-	-	-	ko00000	-	-	-	SpoIIIAC
HKD2_k127_6701457_2	1304284.L21TH_2210	3.742e-42	158.0	2CPUI@1|root,32SJW@2|Bacteria,1VA9Y@1239|Firmicutes,24NK6@186801|Clostridia,36JVA@31979|Clostridiaceae	186801|Clostridia	S	Stage III sporulation protein AD	spoIIIAD	-	-	ko:K06393	-	-	-	-	ko00000	-	-	-	SpoIIIAC
HKD2_k127_6713541_6	994573.T472_0202285	2.517e-89	301.0	COG0805@1|root,COG0805@2|Bacteria,1U7N7@1239|Firmicutes,24KCD@186801|Clostridia,36IND@31979|Clostridiaceae	186801|Clostridia	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes	tatC	-	-	ko:K03118	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	TatC
HKD2_k127_6713541_3	1145276.T479_23425	8.369e-148	476.0	COG0225@1|root,COG0229@1|root,COG0225@2|Bacteria,COG0229@2|Bacteria,1TQ3E@1239|Firmicutes,4IV7U@91061|Bacilli	91061|Bacilli	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	-	-	1.8.4.11,1.8.4.12	ko:K12267	-	-	-	-	ko00000,ko01000	-	-	-	PMSR,SelR
HKD2_k127_6713541_0	293826.Amet_3211	6.185e-219	682.0	COG1775@1|root,COG1775@2|Bacteria,1TPEF@1239|Firmicutes,24A11@186801|Clostridia,36FZP@31979|Clostridiaceae	186801|Clostridia	E	2-hydroxyglutaryl-CoA dehydratase, D-component	-	-	-	-	-	-	-	-	-	-	-	-	HGD-D
HKD2_k127_6713541_4	350688.Clos_2148	4.305e-116	378.0	COG1924@1|root,COG1924@2|Bacteria,1TQSD@1239|Firmicutes,2481W@186801|Clostridia,36F30@31979|Clostridiaceae	186801|Clostridia	I	CoA-substrate-specific enzyme activase	hgdC	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG
HKD2_k127_6713541_5	1121342.AUCO01000005_gene321	2.769e-104	347.0	COG1893@1|root,COG1893@2|Bacteria,1UM1M@1239|Firmicutes,249J4@186801|Clostridia,36GPS@31979|Clostridiaceae	186801|Clostridia	H	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid	-	-	1.1.1.169	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R02472	RC00726	ko00000,ko00001,ko00002,ko01000	-	-	-	ApbA,ApbA_C
HKD2_k127_6713541_8	290402.Cbei_2278	7.663e-16	79.0	COG4309@1|root,COG4309@2|Bacteria,1VHYE@1239|Firmicutes,24RCX@186801|Clostridia,36KND@31979|Clostridiaceae	186801|Clostridia	S	Uncharacterized conserved protein (DUF2249)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2249,Hemerythrin
HKD2_k127_6713541_1	857293.CAAU_2589	8.996e-218	681.0	COG0112@1|root,COG0112@2|Bacteria,1TQVM@1239|Firmicutes,248W5@186801|Clostridia,36EMY@31979|Clostridiaceae	186801|Clostridia	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
HKD2_k127_6713541_2	1321778.HMPREF1982_00248	3.948e-162	519.0	COG1249@1|root,COG1249@2|Bacteria,1TP1W@1239|Firmicutes,249R3@186801|Clostridia,267IQ@186813|unclassified Clostridiales	186801|Clostridia	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain	lpdA	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Biotin_lipoyl,Pyr_redox_2,Pyr_redox_dim
HKD2_k127_6726801_16	1122921.KB898186_gene4731	1.835e-08	55.0	2DJVB@1|root,307G2@2|Bacteria,1U1M7@1239|Firmicutes,4IB3N@91061|Bacilli,273NB@186822|Paenibacillaceae	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6726801_13	1304284.L21TH_1305	2.299e-49	184.0	2B51H@1|root,31XUS@2|Bacteria,1V6KA@1239|Firmicutes,24JQP@186801|Clostridia,36HST@31979|Clostridiaceae	186801|Clostridia	S	sporulation protein YunB	yunB	-	-	-	-	-	-	-	-	-	-	-	Spore_YunB
HKD2_k127_6726801_1	555079.Toce_1390	1.574e-209	678.0	COG0744@1|root,COG0744@2|Bacteria,1TPM5@1239|Firmicutes,248A4@186801|Clostridia,42EPS@68295|Thermoanaerobacterales	186801|Clostridia	M	PFAM glycosyl transferase, family 51	pbpA1	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase
HKD2_k127_6726801_8	941824.TCEL_00407	1.835e-62	220.0	29419@1|root,2ZRG2@2|Bacteria,1V3UB@1239|Firmicutes,24HF4@186801|Clostridia,36IT4@31979|Clostridiaceae	186801|Clostridia	S	Stage V sporulation protein AE1	spoVAEA	-	-	ko:K06407	-	-	-	-	ko00000	-	-	-	SpoVAE
HKD2_k127_6726801_12	351627.Csac_0090	8.708e-52	184.0	2ANER@1|root,315MJ@2|Bacteria,1V6SU@1239|Firmicutes,24JBZ@186801|Clostridia,42GUF@68295|Thermoanaerobacterales	186801|Clostridia	S	TIGRFAM stage V sporulation protein AE	spoVAE	-	-	ko:K06407	-	-	-	-	ko00000	-	-	-	SpoVAC_SpoVAEB
HKD2_k127_6726801_3	935948.KE386495_gene2200	1.496e-153	491.0	COG0183@1|root,COG0183@2|Bacteria,1UHVW@1239|Firmicutes,248BM@186801|Clostridia,42F5C@68295|Thermoanaerobacterales	186801|Clostridia	I	PFAM Stage V sporulation AD	spoVAD	-	-	ko:K06406	-	-	-	-	ko00000	-	-	-	SpoVAD
HKD2_k127_6726801_10	697281.Mahau_1171	9.688e-58	204.0	2ANER@1|root,31DDD@2|Bacteria,1V46U@1239|Firmicutes,24JDI@186801|Clostridia,42GH0@68295|Thermoanaerobacterales	186801|Clostridia	S	stage V sporulation protein AC	spoVAC	-	-	ko:K06405	-	-	-	-	ko00000	-	-	-	SpoVAC_SpoVAEB
HKD2_k127_6726801_7	1121289.JHVL01000004_gene2088	4.096e-88	297.0	COG1191@1|root,COG1191@2|Bacteria,1TP3Q@1239|Firmicutes,2487Z@186801|Clostridia,36EZ8@31979|Clostridiaceae	186801|Clostridia	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	sigF	-	-	ko:K03091	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r3,Sigma70_r4
HKD2_k127_6726801_11	1031288.AXAA01000005_gene2084	1.567e-55	197.0	COG2172@1|root,COG2172@2|Bacteria,1V6V2@1239|Firmicutes,24JPT@186801|Clostridia,36ITI@31979|Clostridiaceae	186801|Clostridia	F	Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition	spoIIAB	-	2.7.11.1	ko:K06379	-	-	-	-	ko00000,ko01000	-	-	-	HATPase_c_2
HKD2_k127_6726801_15	697303.Thewi_1265	7.666e-27	113.0	COG1366@1|root,COG1366@2|Bacteria,1VENG@1239|Firmicutes,24R0X@186801|Clostridia,42GW0@68295|Thermoanaerobacterales	186801|Clostridia	T	Anti-sigma F factor antagonist	spoIIAA	-	-	ko:K06378	-	-	-	-	ko00000	-	-	-	STAS
HKD2_k127_6726801_6	635013.TherJR_1332	1.607e-97	330.0	COG0707@1|root,COG0707@2|Bacteria,1UQ6A@1239|Firmicutes,248FR@186801|Clostridia,2612Z@186807|Peptococcaceae	186801|Clostridia	M	PFAM Glycosyltransferase family 28 C-terminal domain	ugtP	-	2.4.1.315	ko:K03429	ko00561,ko01100,map00561,map01100	-	R02689,R04377	RC00005,RC00059	ko00000,ko00001,ko01000,ko01003	-	GT28	-	Glyco_tran_28_C,MGDG_synth
HKD2_k127_6726801_4	1321778.HMPREF1982_03779	2.61e-139	446.0	COG0421@1|root,COG0421@2|Bacteria,1TPG5@1239|Firmicutes,24827@186801|Clostridia,267QS@186813|unclassified Clostridiales	186801|Clostridia	E	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	speE	-	2.5.1.16	ko:K00797	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	M00034,M00133	R01920,R02869,R08359	RC00021,RC00053	ko00000,ko00001,ko00002,ko01000	-	-	-	Spermine_synt_N,Spermine_synth
HKD2_k127_6726801_0	697303.Thewi_1132	5.716e-237	740.0	COG1982@1|root,COG1982@2|Bacteria,1TNZ9@1239|Firmicutes,247RA@186801|Clostridia,42FKZ@68295|Thermoanaerobacterales	186801|Clostridia	E	PFAM Orn Lys Arg decarboxylase major	speA	-	4.1.1.18,4.1.1.19	ko:K01582,ko:K01585	ko00310,ko00330,ko00960,ko01100,ko01110,map00310,map00330,map00960,map01100,map01110	M00133	R00462,R00566	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	OKR_DC_1,OKR_DC_1_C
HKD2_k127_6726801_2	1230342.CTM_11425	7.402e-161	511.0	COG0252@1|root,COG0252@2|Bacteria,1TPP9@1239|Firmicutes,248F3@186801|Clostridia,36EB6@31979|Clostridiaceae	186801|Clostridia	EJ	L-asparaginase	ansA	-	3.5.1.1	ko:K01424	ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110	-	R00485	RC00010,RC02798	ko00000,ko00001,ko01000	-	-	-	Asparaginase
HKD2_k127_6726801_5	632292.Calhy_1362	2.22e-124	402.0	COG0005@1|root,COG0005@2|Bacteria,1TQ37@1239|Firmicutes,247KQ@186801|Clostridia,42EWQ@68295|Thermoanaerobacterales	186801|Clostridia	F	Purine nucleoside phosphorylase which is highly specific for 6-oxopurine nucleosides. Cleaves guanosine or inosine to respective bases and sugar-1-phosphate molecules. Involved in purine salvage	mtaP	-	2.4.2.1,2.4.2.28	ko:K00772,ko:K03783	ko00230,ko00240,ko00270,ko00760,ko01100,ko01110,map00230,map00240,map00270,map00760,map01100,map01110	M00034	R01402,R01561,R01863,R01969,R02147,R02294,R02295,R02297,R02484,R02557,R02748,R08368,R10244	RC00033,RC00063,RC00122,RC02819	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
HKD2_k127_6726801_14	536227.CcarbDRAFT_2999	1.524e-31	131.0	COG1825@1|root,COG1825@2|Bacteria,1VA38@1239|Firmicutes,24N24@186801|Clostridia,36JYR@31979|Clostridiaceae	186801|Clostridia	J	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance	ctc	-	-	ko:K02897	ko03010,map03010	M00178	-	-	ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L25p,Ribosomal_TL5_C
HKD2_k127_6726801_9	1304880.JAGB01000001_gene825	6.253e-61	213.0	COG1751@1|root,COG1751@2|Bacteria,1V1CN@1239|Firmicutes,24G0M@186801|Clostridia	186801|Clostridia	S	PFAM Pyruvate kinase, alpha beta domain	-	-	-	ko:K09126	-	-	-	-	ko00000	-	-	-	PK_C
HKD2_k127_6735068_2	1304880.JAGB01000002_gene1718	9.811e-19	90.0	COG3250@1|root,COG3250@2|Bacteria,1TPK7@1239|Firmicutes,247VE@186801|Clostridia	186801|Clostridia	G	Belongs to the glycosyl hydrolase 2 family	-	-	3.2.1.23	ko:K01190	ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100	-	R01105,R01678,R03355,R04783,R06114	RC00049,RC00452	ko00000,ko00001,ko01000	-	-	-	DUF4982,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N
HKD2_k127_6735068_1	586413.CCDL010000003_gene2781	4.124e-65	232.0	COG2207@1|root,COG2207@2|Bacteria,1VD9R@1239|Firmicutes	1239|Firmicutes	K	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18
HKD2_k127_6735068_0	332101.JIBU02000023_gene4627	6.4e-77	260.0	COG2755@1|root,COG2755@2|Bacteria,1V1CQ@1239|Firmicutes,24G68@186801|Clostridia,36JKX@31979|Clostridiaceae	186801|Clostridia	E	GDSL-like Lipase/Acylhydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
HKD2_k127_6736492_1	1304875.JAFZ01000001_gene1948	5.554e-26	108.0	COG0662@1|root,COG0662@2|Bacteria	2|Bacteria	G	Cupin 2, conserved barrel domain protein	-	-	-	ko:K21700	-	-	-	-	ko00000	-	-	-	Cupin_2,HTH_18,HTH_AraC
HKD2_k127_6736492_0	411902.CLOBOL_04038	4.479e-233	732.0	COG1288@1|root,COG1288@2|Bacteria,1TQJ0@1239|Firmicutes,248UK@186801|Clostridia,222HP@1506553|Lachnoclostridium	186801|Clostridia	S	C4-dicarboxylate anaerobic carrier	-	-	-	-	-	-	-	-	-	-	-	-	DcuC
HKD2_k127_6738616_10	1321778.HMPREF1982_01768	5.416e-65	224.0	COG1162@1|root,COG1162@2|Bacteria,1TP8Q@1239|Firmicutes,249F8@186801|Clostridia,26BMK@186813|unclassified Clostridiales	186801|Clostridia	S	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit	rsgA	-	3.1.3.100	ko:K06949	ko00730,ko01100,map00730,map01100	-	R00615,R02135	RC00002,RC00017	ko00000,ko00001,ko01000,ko03009	-	-	-	Acetyltransf_1,RsgA_GTPase
HKD2_k127_6738616_8	445335.CBN_0621	2.009e-91	304.0	COG0681@1|root,COG0681@2|Bacteria,1V7H9@1239|Firmicutes,24MVR@186801|Clostridia,36JNX@31979|Clostridiaceae	186801|Clostridia	U	Signal peptidase, peptidase S26	lepB	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24,Peptidase_S26
HKD2_k127_6738616_9	484770.UFO1_4633	7.93e-88	295.0	COG3142@1|root,COG3142@2|Bacteria,1UYI8@1239|Firmicutes,4H5W0@909932|Negativicutes	909932|Negativicutes	P	Participates in the control of copper homeostasis	cutC	-	-	ko:K06201	-	-	-	-	ko00000	-	-	-	CutC
HKD2_k127_6738616_0	931276.Cspa_c15110	0.0	1163.0	COG0330@1|root,COG0330@2|Bacteria,1UY1Y@1239|Firmicutes,24C8M@186801|Clostridia,36E6J@31979|Clostridiaceae	186801|Clostridia	O	SPFH domain / Band 7 family	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
HKD2_k127_6738616_4	1321778.HMPREF1982_04369	1.264e-195	616.0	COG0500@1|root,COG0789@1|root,COG0789@2|Bacteria,COG2226@2|Bacteria,1TSDZ@1239|Firmicutes,248EY@186801|Clostridia	186801|Clostridia	KQ	Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	MerR_1,Methyltransf_11,Methyltransf_25,Methyltransf_31
HKD2_k127_6738616_5	195103.CPF_0600	5.693e-184	578.0	COG1088@1|root,COG1088@2|Bacteria,1TPWM@1239|Firmicutes,247NE@186801|Clostridia,36E4G@31979|Clostridiaceae	186801|Clostridia	M	Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily	rfbB	-	4.2.1.46	ko:K01710	ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130	M00793	R06513	RC00402	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS02615	GDP_Man_Dehyd
HKD2_k127_6738616_6	272562.CA_C2534	6.103e-171	546.0	COG2206@1|root,COG2206@2|Bacteria,1TS2E@1239|Firmicutes,249S8@186801|Clostridia,36F71@31979|Clostridiaceae	186801|Clostridia	T	PFAM metal-dependent phosphohydrolase HD sub domain	-	-	-	-	-	-	-	-	-	-	-	-	HD,HD_5
HKD2_k127_6738616_1	1321778.HMPREF1982_01751	8.852e-280	870.0	COG0768@1|root,COG0768@2|Bacteria,1TP93@1239|Firmicutes,248KB@186801|Clostridia,26862@186813|unclassified Clostridiales	186801|Clostridia	M	Penicillin-binding Protein dimerisation domain	spoVD	-	3.4.16.4	ko:K03587,ko:K08384	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011,ko03036	-	-	-	PASTA,PBP_dimer,Transpeptidase
HKD2_k127_6738616_14	1499680.CCFE01000025_gene3259	2.799e-10	64.0	COG1595@1|root,COG1595@2|Bacteria,1UAQW@1239|Firmicutes,4IM3J@91061|Bacilli,1ZJ12@1386|Bacillus	91061|Bacilli	K	Sigma-70 region 2	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD2_k127_6738616_12	457396.CSBG_01556	3.389e-40	151.0	COG1942@1|root,COG1942@2|Bacteria,1VA6U@1239|Firmicutes,24MXT@186801|Clostridia,36KV1@31979|Clostridiaceae	186801|Clostridia	S	Domain of unknown function (DUF1904)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1904
HKD2_k127_6738616_13	1268072.PSAB_17005	2.294e-30	125.0	COG0454@1|root,COG0454@2|Bacteria,COG0456@2|Bacteria,1V5PF@1239|Firmicutes,4IUVM@91061|Bacilli	91061|Bacilli	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_10
HKD2_k127_6738616_7	1121289.JHVL01000014_gene1765	8.796e-103	338.0	COG2964@1|root,COG2964@2|Bacteria,1V2VD@1239|Firmicutes,24GH7@186801|Clostridia,36GYC@31979|Clostridiaceae	186801|Clostridia	S	HTH domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_22,PAS_6
HKD2_k127_6738616_11	1121289.JHVL01000014_gene1766	8.576e-55	194.0	COG0251@1|root,COG0251@2|Bacteria,1V6HG@1239|Firmicutes,24J8Y@186801|Clostridia,36JHE@31979|Clostridiaceae	186801|Clostridia	J	endoribonuclease L-PSP	yjgF	-	3.5.99.10	ko:K09022	-	-	R11098,R11099	RC03275,RC03354	ko00000,ko01000	-	-	-	Ribonuc_L-PSP
HKD2_k127_6738616_3	1410653.JHVC01000013_gene3635	3.503e-257	797.0	COG3033@1|root,COG3033@2|Bacteria,1TRGV@1239|Firmicutes,248WC@186801|Clostridia,36G6C@31979|Clostridiaceae	186801|Clostridia	E	Belongs to the beta-eliminating lyase family	tnaA	-	4.1.99.1	ko:K01667	ko00380,map00380	-	R00673	RC00209,RC00355	ko00000,ko00001,ko01000	-	-	-	Beta_elim_lyase
HKD2_k127_6738616_2	1286171.EAL2_808p06700	1.931e-269	835.0	COG0733@1|root,COG0733@2|Bacteria,1TP6B@1239|Firmicutes,2485D@186801|Clostridia,25V7V@186806|Eubacteriaceae	186801|Clostridia	S	Belongs to the sodium neurotransmitter symporter (SNF) (TC 2.A.22) family	-	-	-	ko:K03308	-	-	-	-	ko00000	2.A.22.4,2.A.22.5	-	-	SNF
HKD2_k127_6740692_1	1304284.L21TH_0072	1.251e-107	366.0	COG0739@1|root,COG3583@1|root,COG0739@2|Bacteria,COG3583@2|Bacteria,1TRWJ@1239|Firmicutes,24A2J@186801|Clostridia,36HF8@31979|Clostridiaceae	186801|Clostridia	M	Peptidase family M23	-	-	-	-	-	-	-	-	-	-	-	-	G5,LysM,Peptidase_M23
HKD2_k127_6740692_3	1304880.JAGB01000002_gene1683	7.669e-60	223.0	COG1404@1|root,COG1404@2|Bacteria,1TQRU@1239|Firmicutes,249H1@186801|Clostridia	186801|Clostridia	O	Belongs to the peptidase S8 family	aprX	-	-	ko:K17734	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S8
HKD2_k127_6740692_5	1304880.JAGB01000002_gene2275	1.089e-16	81.0	2E3RD@1|root,32YP3@2|Bacteria,1VHRF@1239|Firmicutes,24TA6@186801|Clostridia	186801|Clostridia	S	Putative regulatory protein	-	-	-	-	-	-	-	-	-	-	-	-	Zn-ribbon_8
HKD2_k127_6740692_4	340099.Teth39_0102	1.674e-41	163.0	COG0308@1|root,COG0308@2|Bacteria,1V5S2@1239|Firmicutes,24HG5@186801|Clostridia,42FW6@68295|Thermoanaerobacterales	186801|Clostridia	E	aminopeptidase N	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_MA_2
HKD2_k127_6740692_2	203119.Cthe_2333	3.807e-99	328.0	COG0745@1|root,COG0745@2|Bacteria,1TPQG@1239|Firmicutes,248Z4@186801|Clostridia,3WIDV@541000|Ruminococcaceae	186801|Clostridia	T	response regulator receiver	walR	-	-	ko:K07658,ko:K07668	ko02020,map02020	M00434,M00459	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
HKD2_k127_6740692_0	1128398.Curi_c28340	1.477e-137	457.0	COG5002@1|root,COG5002@2|Bacteria,1TQ1H@1239|Firmicutes,247VG@186801|Clostridia,26886@186813|unclassified Clostridiales	186801|Clostridia	T	ATPase histidine kinase DNA gyrase B HSP90 domain protein	yycG	-	2.7.13.3	ko:K07652	ko02020,map02020	M00459	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_8,PAS_9
HKD2_k127_6744144_4	536232.CLM_1969	1.162e-118	388.0	COG1737@1|root,COG1737@2|Bacteria,1TP7H@1239|Firmicutes,248ZD@186801|Clostridia,36DZB@31979|Clostridiaceae	186801|Clostridia	K	transcriptional regulator, RpiR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_6,SIS
HKD2_k127_6744144_9	865861.AZSU01000003_gene1784	5.283e-64	224.0	COG1014@1|root,COG1014@2|Bacteria,1V3RG@1239|Firmicutes,24I3Y@186801|Clostridia,36IU6@31979|Clostridiaceae	186801|Clostridia	C	Pyruvate ferredoxin/flavodoxin oxidoreductase	korC	-	1.2.7.3	ko:K00177	ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200	M00009,M00011,M00173,M00620	R01197	RC00004,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR
HKD2_k127_6744144_3	1304284.L21TH_0859	2.164e-132	426.0	COG1013@1|root,COG1013@2|Bacteria,1TQJ2@1239|Firmicutes,25CAJ@186801|Clostridia,36WSB@31979|Clostridiaceae	186801|Clostridia	C	PFAM thiamine pyrophosphate protein domain protein TPP-binding	korB	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
HKD2_k127_6744144_1	1347392.CCEZ01000043_gene437	4.243e-162	518.0	COG0674@1|root,COG0674@2|Bacteria,1TSSC@1239|Firmicutes,248I6@186801|Clostridia,36GS6@31979|Clostridiaceae	186801|Clostridia	C	Pyruvate:ferredoxin oxidoreductase core domain II	korA	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
HKD2_k127_6744144_12	697303.Thewi_1294	5.141e-22	97.0	COG4231@1|root,COG4231@2|Bacteria,1UHX9@1239|Firmicutes,24UZM@186801|Clostridia,42H2G@68295|Thermoanaerobacterales	186801|Clostridia	C	Best Blastp hit gi 7431974 pir F72256 'Fe-hydrogenase, subunit beta - Thermotoga maritima (strain MSB8)' gi 2865516 gb AAC02685.1 (AF044577) Fe-hydrogenase beta subunit Thermotoga maritima gi 4981989 gb AAD36495.1 AE001794_11 '(AE001794) Fe-hydrogenase, subunit beta Thermotoga maritima ', score	-	-	1.2.7.3	ko:K00176	ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200	M00009,M00011,M00173,M00620	R01197	RC00004,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4
HKD2_k127_6744144_7	635013.TherJR_1929	8.988e-83	282.0	COG0496@1|root,COG0496@2|Bacteria,1TS2T@1239|Firmicutes,24BI5@186801|Clostridia,260JN@186807|Peptococcaceae	186801|Clostridia	S	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates	surE	-	3.1.3.5	ko:K03787	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	SurE
HKD2_k127_6744144_8	340099.Teth39_1147	1.289e-76	263.0	arCOG11023@1|root,2ZBVW@2|Bacteria,1V1HI@1239|Firmicutes,24G3M@186801|Clostridia,42I6C@68295|Thermoanaerobacterales	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6744144_0	293826.Amet_2638	2.973e-225	705.0	COG5016@1|root,COG5016@2|Bacteria,1VT8P@1239|Firmicutes,247NZ@186801|Clostridia,36UI3@31979|Clostridiaceae	186801|Clostridia	C	carboxyltransferase	pycB	-	4.1.1.3	ko:K01571	ko00620,ko01100,map00620,map01100	-	R00217	RC00040	ko00000,ko00001,ko01000,ko02000	3.B.1.1.1	-	-	HMGL-like,PYC_OADA
HKD2_k127_6744144_6	935948.KE386495_gene2211	8.46e-87	293.0	COG1187@1|root,COG1187@2|Bacteria,1TP68@1239|Firmicutes,248UG@186801|Clostridia,42G4B@68295|Thermoanaerobacterales	186801|Clostridia	J	Belongs to the pseudouridine synthase RsuA family	rluB	-	5.4.99.19,5.4.99.22	ko:K06178,ko:K06183	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
HKD2_k127_6744144_5	2325.TKV_c12510	5.06e-108	361.0	COG1686@1|root,COG1686@2|Bacteria,1TQ8M@1239|Firmicutes,2480S@186801|Clostridia,42F4N@68295|Thermoanaerobacterales	186801|Clostridia	M	PFAM peptidase S11, D-alanyl-D-alanine carboxypeptidase	dacB1	-	3.4.16.4	ko:K07258	ko00550,ko01100,map00550,map01100	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	PBP5_C,Peptidase_S11
HKD2_k127_6744144_10	350688.Clos_1581	1.787e-54	194.0	2C10H@1|root,32Y7M@2|Bacteria,1VWCW@1239|Firmicutes,251DH@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	MazG
HKD2_k127_6744144_11	756499.Desde_2860	2.149e-38	147.0	COG3874@1|root,COG3874@2|Bacteria,1V6H7@1239|Firmicutes,24JJ5@186801|Clostridia,26234@186807|Peptococcaceae	186801|Clostridia	S	TIGRFAM sporulation protein YtfJ	ytfJ	-	-	-	-	-	-	-	-	-	-	-	Spore_YtfJ
HKD2_k127_6744144_13	580327.Tthe_1343	5.194e-12	74.0	2DPB7@1|root,331CK@2|Bacteria,1VIJ5@1239|Firmicutes,24TJR@186801|Clostridia,42H8P@68295|Thermoanaerobacterales	186801|Clostridia	S	Protein of unknown function (DUF2953)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2953
HKD2_k127_6744144_2	509191.AEDB02000063_gene436	2.192e-137	444.0	COG0389@1|root,COG0389@2|Bacteria,1TP42@1239|Firmicutes,24855@186801|Clostridia,3WIS6@541000|Ruminococcaceae	186801|Clostridia	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	dinB	-	2.7.7.7	ko:K02346	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C,IMS_HHH
HKD2_k127_6749903_3	1122927.KB895412_gene1061	6.212e-05	48.0	COG1073@1|root,COG1073@2|Bacteria,1TQYU@1239|Firmicutes,4HC4H@91061|Bacilli,26T37@186822|Paenibacillaceae	91061|Bacilli	S	Alpha beta	ybcH	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	DLH,Hydrolase_4
HKD2_k127_6749903_0	1196322.A370_05919	7.041e-132	430.0	COG0787@1|root,COG0787@2|Bacteria,1TNYY@1239|Firmicutes,24YKG@186801|Clostridia,36QXR@31979|Clostridiaceae	186801|Clostridia	M	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids	-	-	5.1.1.1	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	-	R00401	RC00285	ko00000,ko00001,ko01000,ko01011	-	-	-	Ala_racemase_C,Ala_racemase_N
HKD2_k127_6749903_1	1499689.CCNN01000007_gene2197	9.341e-105	344.0	COG0204@1|root,COG0204@2|Bacteria,1UMJA@1239|Firmicutes,249AV@186801|Clostridia,36EYB@31979|Clostridiaceae	186801|Clostridia	I	Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family	plsC	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
HKD2_k127_6749903_2	350688.Clos_2107	9.865e-89	298.0	COG4242@1|root,COG4242@2|Bacteria,1TSFA@1239|Firmicutes,249S4@186801|Clostridia,36FVF@31979|Clostridiaceae	186801|Clostridia	PQ	Belongs to the peptidase S51 family	cphB	-	3.4.15.6	ko:K13282	-	-	R09722	RC00064,RC00141	ko00000,ko01000,ko01002	-	-	-	Peptidase_S51
HKD2_k127_6750744_4	1301100.HG529322_gene6068	4.72e-13	69.0	COG1670@1|root,COG1670@2|Bacteria,1V40U@1239|Firmicutes,24JVI@186801|Clostridia,36IBY@31979|Clostridiaceae	186801|Clostridia	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
HKD2_k127_6750744_3	485916.Dtox_1548	8.279e-29	122.0	COG1514@1|root,COG1514@2|Bacteria,1VGSY@1239|Firmicutes,24RFI@186801|Clostridia,2651F@186807|Peptococcaceae	186801|Clostridia	J	2'-5' RNA ligase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	2_5_RNA_ligase2
HKD2_k127_6750744_0	1499689.CCNN01000009_gene2788	2.878e-94	311.0	COG1051@1|root,COG1051@2|Bacteria,1V1P7@1239|Firmicutes,24FSG@186801|Clostridia,36HYH@31979|Clostridiaceae	186801|Clostridia	F	hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
HKD2_k127_6750744_2	1540257.JQMW01000009_gene3811	2.568e-45	170.0	COG1713@1|root,COG1713@2|Bacteria,1V44H@1239|Firmicutes,24J6Q@186801|Clostridia,36J7N@31979|Clostridiaceae	186801|Clostridia	H	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	HD
HKD2_k127_6750744_1	1237149.C900_02138	1.956e-46	173.0	COG0716@1|root,COG0716@2|Bacteria,4NVV8@976|Bacteroidetes	976|Bacteroidetes	C	FMN binding	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6750744_5	319224.Sputcn32_3005	6.775e-05	53.0	COG1266@1|root,COG1266@2|Bacteria,1R5V2@1224|Proteobacteria,1S57F@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
HKD2_k127_6767174_1	1121289.JHVL01000050_gene2020	5.399e-124	408.0	COG1306@1|root,COG1306@2|Bacteria,1TQZV@1239|Firmicutes,24ADG@186801|Clostridia,36EXJ@31979|Clostridiaceae	186801|Clostridia	S	Putative glycosyl hydrolase domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4015
HKD2_k127_6767174_0	1408422.JHYF01000020_gene1828	2.793e-294	912.0	COG0209@1|root,COG0209@2|Bacteria,1TT3U@1239|Firmicutes,24C4U@186801|Clostridia,36G9Z@31979|Clostridiaceae	186801|Clostridia	F	TIGRFAM ribonucleoside-triphosphate reductase, adenosylcobalamin-dependent	-	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	ATP-cone,Ribonuc_red_lgC
HKD2_k127_6767927_1	1122919.KB905584_gene3897	1.82e-31	124.0	COG1653@1|root,COG1653@2|Bacteria,1TPWV@1239|Firmicutes,4HEIR@91061|Bacilli,275IK@186822|Paenibacillaceae	91061|Bacilli	G	Extracellular solute-binding protein	-	-	-	ko:K17318	ko02010,map02010	M00603	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.29,3.A.1.1.9	-	-	DUF3502,SBP_bac_1,SBP_bac_8
HKD2_k127_6767927_0	632292.Calhy_2347	3.071e-178	571.0	COG1129@1|root,COG1129@2|Bacteria,1TP6I@1239|Firmicutes,247II@186801|Clostridia	186801|Clostridia	G	import. Responsible for energy coupling to the transport system	-	-	3.6.3.17	ko:K10441	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	ABC_tran
HKD2_k127_6807272_11	138119.DSY3068	2.443e-148	473.0	COG0644@1|root,COG0644@2|Bacteria,1UZT1@1239|Firmicutes,25DJ8@186801|Clostridia	186801|Clostridia	C	oxidoreductase	cbrA	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3,Lycopene_cycl,NAD_binding_8
HKD2_k127_6807272_24	641107.CDLVIII_3965	2.786e-34	132.0	COG3655@1|root,COG3655@2|Bacteria,1VESP@1239|Firmicutes,24QSQ@186801|Clostridia,36KI4@31979|Clostridiaceae	186801|Clostridia	K	Transcriptional regulator	-	-	-	ko:K07727	-	-	-	-	ko00000,ko03000	-	-	-	HTH_26
HKD2_k127_6807272_16	1461580.CCAS010000044_gene3405	1.035e-74	253.0	293T3@1|root,2ZR8H@2|Bacteria,1V593@1239|Firmicutes,4HG8Q@91061|Bacilli,1ZFS5@1386|Bacillus	91061|Bacilli	S	Protein of unknown function (DUF2975)	yoaS	-	-	-	-	-	-	-	-	-	-	-	DUF2975
HKD2_k127_6807272_1	756499.Desde_1773	0.0	1409.0	COG0480@1|root,COG3688@1|root,COG0480@2|Bacteria,COG3688@2|Bacteria,1TPQH@1239|Firmicutes,247X4@186801|Clostridia,263J1@186807|Peptococcaceae	186801|Clostridia	J	Elongation factor Tu GTP binding domain	tetP	-	-	-	-	-	-	-	-	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,NYN_YacP
HKD2_k127_6807272_2	293826.Amet_1553	1e-323	996.0	COG0488@1|root,COG0488@2|Bacteria,1TSB8@1239|Firmicutes,248XT@186801|Clostridia,36F92@31979|Clostridiaceae	186801|Clostridia	S	ABC transporter	-	-	-	ko:K06158	-	-	-	-	ko00000,ko03012	-	-	-	ABC_tran,ABC_tran_Xtn
HKD2_k127_6807272_18	86416.Clopa_2706	7.225e-59	206.0	COG0789@1|root,COG0789@2|Bacteria,1VAAP@1239|Firmicutes,24JJN@186801|Clostridia,36JS7@31979|Clostridiaceae	186801|Clostridia	K	transcriptional regulator	adhR	-	-	-	-	-	-	-	-	-	-	-	MerR,MerR_1
HKD2_k127_6807272_7	1487921.DP68_12590	1.436e-197	618.0	COG2768@1|root,COG2768@2|Bacteria,1TQAW@1239|Firmicutes,247IS@186801|Clostridia,36EQY@31979|Clostridiaceae	186801|Clostridia	C	PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	-	ko:K07138	-	-	-	-	ko00000	-	-	-	DUF362,Fer4
HKD2_k127_6807272_14	994573.T472_0207645	1.539e-99	328.0	COG1309@1|root,COG1309@2|Bacteria,1VCMC@1239|Firmicutes,24ND2@186801|Clostridia,36MGW@31979|Clostridiaceae	186801|Clostridia	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
HKD2_k127_6807272_25	994573.T472_0207640	4.233e-30	123.0	COG3976@1|root,COG3976@2|Bacteria,1VH0E@1239|Firmicutes	1239|Firmicutes	S	FMN_bind	-	-	-	-	-	-	-	-	-	-	-	-	FMN_bind
HKD2_k127_6807272_6	994573.T472_0207635	3.657e-220	691.0	COG1053@1|root,COG1053@2|Bacteria,1TT1Q@1239|Firmicutes,249N4@186801|Clostridia,36I83@31979|Clostridiaceae	186801|Clostridia	C	FAD dependent oxidoreductase	-	-	1.3.5.4	ko:K00244	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020	M00009,M00011,M00150,M00173	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,FMN_bind
HKD2_k127_6807272_23	1321778.HMPREF1982_02622	5.302e-43	159.0	2E6A2@1|root,330XY@2|Bacteria,1VISZ@1239|Firmicutes,24QK3@186801|Clostridia	186801|Clostridia	S	Psort location Cytoplasmic, score 8.87	-	-	-	-	-	-	-	-	-	-	-	-	PqqD
HKD2_k127_6807272_3	1321778.HMPREF1982_02624	2.017e-308	955.0	COG1297@1|root,COG1297@2|Bacteria,1TQJP@1239|Firmicutes,247JY@186801|Clostridia	186801|Clostridia	S	oligopeptide transporter, OPT family	-	-	-	-	-	-	-	-	-	-	-	-	OPT
HKD2_k127_6807272_13	410358.Mlab_1708	9.336e-100	344.0	COG1511@1|root,arCOG06504@2157|Archaea	2157|Archaea	S	ABC-2 family transporter protein	-	-	-	ko:K01421	-	-	-	-	ko00000	-	-	-	ABC2_membrane_3
HKD2_k127_6807272_5	1408422.JHYF01000008_gene3803	1.54e-221	707.0	COG1033@1|root,COG1033@2|Bacteria,1VSWA@1239|Firmicutes,247R6@186801|Clostridia,36DHN@31979|Clostridiaceae	186801|Clostridia	S	Psort location CytoplasmicMembrane, score	-	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
HKD2_k127_6807272_20	394503.Ccel_2357	1.29e-53	194.0	COG1309@1|root,COG1309@2|Bacteria,1V4M4@1239|Firmicutes,25BEU@186801|Clostridia,36WFU@31979|Clostridiaceae	186801|Clostridia	K	Transcriptional regulator C-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_8,TetR_N
HKD2_k127_6807272_17	357809.Cphy_1614	5.158e-71	245.0	COG0744@1|root,COG0744@2|Bacteria,1V1XZ@1239|Firmicutes,24APC@186801|Clostridia,21Y03@1506553|Lachnoclostridium	186801|Clostridia	M	Transglycosylase	-	-	-	-	-	-	-	-	-	-	-	-	Transgly
HKD2_k127_6807272_9	1321778.HMPREF1982_02940	2.792e-160	507.0	COG2207@1|root,COG3708@1|root,COG2207@2|Bacteria,COG3708@2|Bacteria,1TPI9@1239|Firmicutes,2496K@186801|Clostridia,267YX@186813|unclassified Clostridiales	186801|Clostridia	K	K13530 AraC family transcriptional regulator, regulatory protein of adaptative response methylphosphotriester-DNA alkyltransferase methyltransferase	-	-	-	ko:K13653	-	-	-	-	ko00000,ko03000	-	-	-	GyrI-like,HTH_18
HKD2_k127_6807272_12	1408422.JHYF01000013_gene592	2.03e-121	392.0	COG0378@1|root,COG0378@2|Bacteria,1TS00@1239|Firmicutes,248T1@186801|Clostridia,36E69@31979|Clostridiaceae	186801|Clostridia	KO	Hydrogenase accessory protein HypB	hypB	-	-	ko:K04652	-	-	-	-	ko00000,ko03110	-	-	-	cobW
HKD2_k127_6807272_0	1408823.AXUS01000019_gene2192	0.0	1474.0	COG0493@1|root,COG1145@1|root,COG0493@2|Bacteria,COG1145@2|Bacteria,1TQ1A@1239|Firmicutes,248EK@186801|Clostridia,25T3S@186804|Peptostreptococcaceae	186801|Clostridia	CE	Thi4 family	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_20,Pyr_redox_2
HKD2_k127_6807272_19	1230342.CTM_06811	4.043e-54	191.0	COG0375@1|root,COG0375@2|Bacteria,1V8EK@1239|Firmicutes,25CVT@186801|Clostridia,36JK2@31979|Clostridiaceae	186801|Clostridia	S	Hydrogenase/urease nickel incorporation, metallochaperone, hypA	-	-	-	ko:K04651	-	-	-	-	ko00000,ko03110	-	-	-	HypA
HKD2_k127_6807272_8	318464.IO99_04220	1.885e-187	588.0	28H6R@1|root,2Z7J3@2|Bacteria,1TQ2I@1239|Firmicutes,247QF@186801|Clostridia,36EPD@31979|Clostridiaceae	186801|Clostridia	S	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6807272_22	1415774.U728_3129	1.13e-50	186.0	COG1309@1|root,COG1309@2|Bacteria,1VG7J@1239|Firmicutes,25B5Y@186801|Clostridia	186801|Clostridia	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
HKD2_k127_6807272_27	1131462.DCF50_p679	2.971e-15	76.0	2DT61@1|root,33IVD@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6807272_4	350688.Clos_0945	1.387e-240	754.0	COG0488@1|root,COG0488@2|Bacteria,1TQNA@1239|Firmicutes,248US@186801|Clostridia,36F40@31979|Clostridiaceae	186801|Clostridia	S	ABC transporter	-	-	-	ko:K18231	ko02010,map02010	-	-	-	br01600,ko00000,ko00001,ko01504,ko02000	3.A.1.121.1,3.A.1.121.3	-	-	ABC_tran,ABC_tran_Xtn
HKD2_k127_6807272_10	1487921.DP68_06715	1.148e-148	475.0	COG0697@1|root,COG0697@2|Bacteria,1TPUW@1239|Firmicutes,247X1@186801|Clostridia,36FB9@31979|Clostridiaceae	186801|Clostridia	EG	DMT(Drug metabolite transporter) superfamily permease	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HKD2_k127_6807272_15	1501230.ET33_34415	5.162e-94	310.0	2CK1P@1|root,2ZC9M@2|Bacteria,1V2AZ@1239|Firmicutes,4HQKI@91061|Bacilli,276WP@186822|Paenibacillaceae	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6807272_26	1286171.EAL2_c08230	1.828e-20	94.0	COG1983@1|root,COG1983@2|Bacteria,1VKBQ@1239|Firmicutes,24QU9@186801|Clostridia,25XUP@186806|Eubacteriaceae	186801|Clostridia	KT	PspC domain	-	-	-	ko:K03973	-	-	-	-	ko00000,ko02048,ko03000	-	-	-	PspC
HKD2_k127_6807272_21	1121342.AUCO01000002_gene907	1.871e-52	188.0	COG4905@1|root,COG4905@2|Bacteria,1VAQJ@1239|Firmicutes,24K5I@186801|Clostridia,36JI5@31979|Clostridiaceae	186801|Clostridia	S	Putative ABC-transporter type IV	-	-	-	-	-	-	-	-	-	-	-	-	ABC_trans_CmpB
HKD2_k127_6807482_0	941824.TCEL_02159	2.884e-174	559.0	COG1694@1|root,COG3956@2|Bacteria,1TPK1@1239|Firmicutes,247XM@186801|Clostridia,36E9N@31979|Clostridiaceae	186801|Clostridia	S	MazG family	mazG	-	3.6.1.66	ko:K02428,ko:K02499	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000,ko03036	-	-	-	MazG,TP_methylase
HKD2_k127_6807482_1	273068.TTE2453	6.515e-36	138.0	COG0776@1|root,COG0776@2|Bacteria,1V9XQ@1239|Firmicutes,24MM0@186801|Clostridia,42GZI@68295|Thermoanaerobacterales	186801|Clostridia	L	Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions	hup	-	-	ko:K03530	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
HKD2_k127_6807482_2	1041504.RATSFB_1277	4.777e-11	63.0	COG1188@1|root,COG1188@2|Bacteria,1VEI5@1239|Firmicutes,24QNF@186801|Clostridia,36KQU@31979|Clostridiaceae	186801|Clostridia	J	S4 domain protein	hslR	-	-	-	-	-	-	-	-	-	-	-	S4
HKD2_k127_68096_0	857293.CAAU_0670	1.295e-126	414.0	COG2195@1|root,COG2195@2|Bacteria,1TQBS@1239|Firmicutes,24860@186801|Clostridia,36DNZ@31979|Clostridiaceae	186801|Clostridia	E	aminoacyl-histidine dipeptidase	pepD	-	-	ko:K01270	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20
HKD2_k127_68096_1	2325.TKV_c01400	2.895e-85	287.0	COG1670@1|root,COG1670@2|Bacteria,1V1G8@1239|Firmicutes,24G73@186801|Clostridia,42G9C@68295|Thermoanaerobacterales	186801|Clostridia	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
HKD2_k127_6822531_1	768706.Desor_0625	1.544e-26	109.0	COG1136@1|root,COG1136@2|Bacteria,1TPBJ@1239|Firmicutes,248EZ@186801|Clostridia,2618D@186807|Peptococcaceae	186801|Clostridia	V	ABC-type antimicrobial peptide transport system, ATPase component	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD2_k127_6822531_0	913865.DOT_0731	7.929e-84	289.0	COG0845@1|root,COG0845@2|Bacteria,1UYE5@1239|Firmicutes,24B3X@186801|Clostridia,26017@186807|Peptococcaceae	186801|Clostridia	M	Barrel-sandwich domain of CusB or HlyD membrane-fusion	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
HKD2_k127_6834732_1	1487921.DP68_13370	3.395e-62	214.0	COG4898@1|root,COG4898@2|Bacteria,1V6U6@1239|Firmicutes,24I63@186801|Clostridia,36K64@31979|Clostridiaceae	186801|Clostridia	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF2200
HKD2_k127_6834732_0	1408422.JHYF01000013_gene569	1.438e-164	529.0	COG5337@1|root,COG5337@2|Bacteria,1U0PJ@1239|Firmicutes,248HG@186801|Clostridia,36E1D@31979|Clostridiaceae	186801|Clostridia	M	CotH protein	-	-	-	-	-	-	-	-	-	-	-	-	CotH
HKD2_k127_6944010_0	1410653.JHVC01000003_gene3876	6.085e-197	622.0	COG0534@1|root,COG0534@2|Bacteria,1TNZN@1239|Firmicutes,247YX@186801|Clostridia,36DT9@31979|Clostridiaceae	186801|Clostridia	V	Mate efflux family protein	-	-	-	-	-	-	-	-	-	-	-	-	MatE
HKD2_k127_6944010_2	588581.Cpap_2863	1.176e-48	177.0	COG1051@1|root,COG1051@2|Bacteria,1UIGB@1239|Firmicutes,24NCA@186801|Clostridia	186801|Clostridia	F	Belongs to the Nudix hydrolase family	mutT	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX
HKD2_k127_6944010_3	1286171.EAL2_c10230	2.946e-33	131.0	COG4997@1|root,COG4997@2|Bacteria,1TV2F@1239|Firmicutes,25I53@186801|Clostridia,25XWZ@186806|Eubacteriaceae	186801|Clostridia	I	bis(5'-adenosyl)-triphosphatase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6944010_1	1121468.AUBR01000019_gene2634	1.076e-68	241.0	COG1600@1|root,COG1600@2|Bacteria,1V0A3@1239|Firmicutes,249D6@186801|Clostridia,42GBE@68295|Thermoanaerobacterales	186801|Clostridia	C	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6944010_4	1408303.JNJJ01000003_gene1037	0.0004353	44.0	COG1476@1|root,COG1476@2|Bacteria,1VYTS@1239|Firmicutes,4ISUU@91061|Bacilli,1ZJY5@1386|Bacillus	91061|Bacilli	K	Helix-turn-helix XRE-family like proteins	-	-	2.1.1.265	ko:K16868	-	-	-	-	ko00000,ko01000	-	-	-	HTH_3,TehB
HKD2_k127_7009180_1	1031288.AXAA01000052_gene759	6.818e-59	210.0	COG1573@1|root,COG1573@2|Bacteria,1V4M9@1239|Firmicutes,24C6M@186801|Clostridia,36E51@31979|Clostridiaceae	186801|Clostridia	L	uracil-DNA glycosylase	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
HKD2_k127_7009180_0	1121342.AUCO01000004_gene591	1.531e-73	253.0	COG0235@1|root,COG0235@2|Bacteria,1TPDV@1239|Firmicutes,248KI@186801|Clostridia,36DCJ@31979|Clostridiaceae	186801|Clostridia	G	L-ribulose-5-phosphate 4-epimerase	araD	-	4.1.2.17,5.1.3.4	ko:K01628,ko:K03077	ko00040,ko00051,ko00053,ko01100,ko01120,map00040,map00051,map00053,map01100,map01120	M00550	R02262,R05850	RC00603,RC00604,RC01479	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS00590	Aldolase_II
HKD2_k127_7009180_2	1540257.JQMW01000009_gene2720	1.111e-41	168.0	COG0726@1|root,COG0726@2|Bacteria,1TYRH@1239|Firmicutes,24BM4@186801|Clostridia,36VG1@31979|Clostridiaceae	186801|Clostridia	G	Polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
HKD2_k127_7009180_3	445335.CBN_A0062	9.004e-17	81.0	2ERMT@1|root,33J79@2|Bacteria,1VKZE@1239|Firmicutes	1239|Firmicutes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7063870_10	1347392.CCEZ01000075_gene3192	2.451e-35	136.0	COG0615@1|root,COG0673@1|root,COG0615@2|Bacteria,COG0673@2|Bacteria,1V3KY@1239|Firmicutes,24BKY@186801|Clostridia,36VGY@31979|Clostridiaceae	186801|Clostridia	IM	Glycerol-3-phosphate cytidylyltransferase	tagD	-	2.7.7.39	ko:K00980	ko00564,map00564	-	R00856	RC00002	ko00000,ko00001,ko01000	-	-	-	CTP_transf_like,GFO_IDH_MocA
HKD2_k127_7063870_2	865861.AZSU01000002_gene2767	6.59e-149	488.0	COG0728@1|root,COG0728@2|Bacteria,1TPFI@1239|Firmicutes,247N3@186801|Clostridia,36FH2@31979|Clostridiaceae	186801|Clostridia	S	Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane	mviN	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN,Polysacc_synt_C
HKD2_k127_7063870_7	1347392.CCEZ01000014_gene2761	9.698e-61	216.0	COG3944@1|root,COG3944@2|Bacteria,1UZCR@1239|Firmicutes,24HS8@186801|Clostridia,36JT4@31979|Clostridiaceae	186801|Clostridia	M	biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	GNVR,Wzz
HKD2_k127_7063870_6	1304880.JAGB01000001_gene955	2.939e-61	218.0	COG0489@1|root,COG0489@2|Bacteria,1TS4R@1239|Firmicutes,24B0Z@186801|Clostridia	186801|Clostridia	D	Capsular exopolysaccharide family	ywqD	-	-	-	-	-	-	-	-	-	-	-	AAA_31,ParA,Wzz
HKD2_k127_7063870_8	1347392.CCEZ01000014_gene2763	2.169e-49	185.0	COG4464@1|root,COG4464@2|Bacteria,1TQ1T@1239|Firmicutes,24JQU@186801|Clostridia,36I15@31979|Clostridiaceae	186801|Clostridia	GM	biosynthesis protein	ywqE	-	3.1.3.48	ko:K01104	-	-	-	-	ko00000,ko01000	-	-	-	-
HKD2_k127_7063870_9	931626.Awo_c20860	1.166e-46	179.0	COG1316@1|root,COG1316@2|Bacteria,1TR1B@1239|Firmicutes,24AAY@186801|Clostridia,25ZG1@186806|Eubacteriaceae	186801|Clostridia	K	Cell envelope-related transcriptional attenuator domain	-	-	-	-	-	-	-	-	-	-	-	-	LytR_cpsA_psr
HKD2_k127_7063870_1	1449050.JNLE01000005_gene5057	9.118e-165	525.0	COG0306@1|root,COG0306@2|Bacteria,1TQ3D@1239|Firmicutes,247ZC@186801|Clostridia,36FB1@31979|Clostridiaceae	186801|Clostridia	P	phosphate transporter	pit	-	-	ko:K03306	-	-	-	-	ko00000	2.A.20	-	-	PHO4
HKD2_k127_7063870_5	1449050.JNLE01000005_gene5056	5.072e-81	274.0	COG1392@1|root,COG1392@2|Bacteria,1UYRI@1239|Firmicutes,24BCU@186801|Clostridia,36DGM@31979|Clostridiaceae	186801|Clostridia	P	phosphate transport regulator	-	-	-	ko:K07220	-	-	-	-	ko00000	-	-	-	PhoU_div
HKD2_k127_7063870_4	1105031.HMPREF1141_2139	5.136e-97	321.0	28H95@1|root,2Z7KY@2|Bacteria,1TQTR@1239|Firmicutes,24BKB@186801|Clostridia,36DST@31979|Clostridiaceae	186801|Clostridia	S	Protein of unknown function (DUF4256)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4256
HKD2_k127_7063870_0	526218.Sterm_2153	9.268e-281	875.0	COG1048@1|root,COG1048@2|Bacteria,378WX@32066|Fusobacteria	32066|Fusobacteria	C	aconitate hydratase	-	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
HKD2_k127_7063870_3	1121324.CLIT_23c04740	1.227e-135	440.0	COG0473@1|root,COG0473@2|Bacteria,1TPEM@1239|Firmicutes,24A63@186801|Clostridia,25QPS@186804|Peptostreptococcaceae	186801|Clostridia	C	Isocitrate dehydrogenase	icd	-	1.1.1.41	ko:K00030	ko00020,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010	R00709	RC00114	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
HKD2_k127_7063870_11	1511.CLOST_1244	5.147e-15	77.0	COG0372@1|root,COG0372@2|Bacteria,1TPPS@1239|Firmicutes,24865@186801|Clostridia,25SK5@186804|Peptostreptococcaceae	186801|Clostridia	C	Citrate synthase, C-terminal domain	gltA	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
HKD2_k127_7065894_2	857293.CAAU_0710	1.703e-58	208.0	COG1597@1|root,COG1597@2|Bacteria,1TQAU@1239|Firmicutes,249SY@186801|Clostridia,36EPM@31979|Clostridiaceae	186801|Clostridia	I	Lipid kinase	dagK	-	2.7.1.107	ko:K07029	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	-	R02240	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	DAGK_cat
HKD2_k127_7065894_3	195103.CPF_1268	3.579e-26	109.0	2E3FD@1|root,32YE7@2|Bacteria,1VEE4@1239|Firmicutes,24QJ7@186801|Clostridia,36MNV@31979|Clostridiaceae	186801|Clostridia	S	TSCPD domain	-	-	-	-	-	-	-	-	-	-	-	-	TSCPD
HKD2_k127_7065894_1	1321778.HMPREF1982_00529	4.477e-85	290.0	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	-	-	-	ko:K18566	ko00332,ko01130,map00332,map01130	-	R10745,R10746	RC00004,RC00096	ko00000,ko00001,ko01000	-	-	-	Acetyltransf_1
HKD2_k127_7065894_0	649747.HMPREF0083_00046	1.537e-121	401.0	COG3853@1|root,COG3853@2|Bacteria,1TQVX@1239|Firmicutes,4H9Z6@91061|Bacilli	91061|Bacilli	P	Belongs to the TelA family	-	-	-	-	-	-	-	-	-	-	-	-	TelA
HKD2_k127_7074100_0	1304880.JAGB01000002_gene2071	4.586e-130	420.0	COG0653@1|root,COG0653@2|Bacteria,1TPEY@1239|Firmicutes,247N2@186801|Clostridia	186801|Clostridia	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	-	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	Helicase_C,SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
HKD2_k127_7074100_1	1121289.JHVL01000017_gene732	9.051e-46	171.0	29Y0M@1|root,30JTI@2|Bacteria,1V50V@1239|Firmicutes,24GAX@186801|Clostridia,36K0I@31979|Clostridiaceae	186801|Clostridia	S	Family of unknown function (DUF5317)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5317
HKD2_k127_7125485_1	350688.Clos_2107	2.569e-29	118.0	COG4242@1|root,COG4242@2|Bacteria,1TSFA@1239|Firmicutes,249S4@186801|Clostridia,36FVF@31979|Clostridiaceae	186801|Clostridia	PQ	Belongs to the peptidase S51 family	cphB	-	3.4.15.6	ko:K13282	-	-	R09722	RC00064,RC00141	ko00000,ko01000,ko01002	-	-	-	Peptidase_S51
HKD2_k127_7125485_0	273068.TTE2785	4.059e-244	771.0	COG0189@1|root,COG0769@1|root,COG0189@2|Bacteria,COG0769@2|Bacteria,1V3WY@1239|Firmicutes,249AA@186801|Clostridia,42F8A@68295|Thermoanaerobacterales	186801|Clostridia	D	Belongs to the MurCDEF family	cphA	-	6.3.2.29,6.3.2.30	ko:K03802	-	-	-	-	ko00000,ko01000	-	-	-	Mur_ligase_C,Mur_ligase_M,RimK
HKD2_k127_7178083_1	1304284.L21TH_0136	1.399e-47	175.0	COG0524@1|root,COG0524@2|Bacteria,1TQRC@1239|Firmicutes,249QQ@186801|Clostridia,36G1Q@31979|Clostridiaceae	186801|Clostridia	H	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway	rbsK	-	2.7.1.15	ko:K00852	ko00030,map00030	-	R01051,R02750	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
HKD2_k127_7178083_0	1304284.L21TH_0137	2.048e-129	421.0	COG1609@1|root,COG1609@2|Bacteria,1TQ7K@1239|Firmicutes,247M2@186801|Clostridia,36F5I@31979|Clostridiaceae	186801|Clostridia	K	Transcriptional regulator, LacI family	rbsR	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_1,Peripla_BP_3
HKD2_k127_7178083_2	696281.Desru_0853	4.305e-25	106.0	COG5460@1|root,COG5460@2|Bacteria,1VG76@1239|Firmicutes,24R3G@186801|Clostridia,265VT@186807|Peptococcaceae	186801|Clostridia	S	Uncharacterized conserved protein (DUF2164)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2164
HKD2_k127_7292819_13	1511.CLOST_1845	8.618e-25	104.0	COG0227@1|root,COG0227@2|Bacteria,1VEI2@1239|Firmicutes,24QNA@186801|Clostridia,25RTD@186804|Peptostreptococcaceae	186801|Clostridia	J	Belongs to the bacterial ribosomal protein bL28 family	rpmB	-	-	ko:K02902	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L28
HKD2_k127_7292819_11	203119.Cthe_0577	1.292e-57	207.0	COG1564@1|root,COG1564@2|Bacteria,1VA0W@1239|Firmicutes,24NG6@186801|Clostridia,3WJUT@541000|Ruminococcaceae	186801|Clostridia	H	thiamine pyrophosphokinase	thiN	-	2.7.6.2	ko:K00949	ko00730,ko01100,map00730,map01100	-	R00619	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	TPK_B1_binding,TPK_catalytic
HKD2_k127_7292819_6	1128398.Curi_c16760	1.857e-86	290.0	COG0036@1|root,COG0036@2|Bacteria,1TQK8@1239|Firmicutes,248AR@186801|Clostridia,268XI@186813|unclassified Clostridiales	186801|Clostridia	G	Ribulose-phosphate 3 epimerase family	rpe	-	5.1.3.1	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
HKD2_k127_7292819_5	350688.Clos_1435	9.595e-92	310.0	COG1162@1|root,COG1162@2|Bacteria,1TPSQ@1239|Firmicutes,248R5@186801|Clostridia,36ETW@31979|Clostridiaceae	186801|Clostridia	S	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit	rsgA	-	3.1.3.100	ko:K06949	ko00730,ko01100,map00730,map01100	-	R00615,R02135	RC00002,RC00017	ko00000,ko00001,ko01000,ko03009	-	-	-	RsgA_GTPase,RsgA_N
HKD2_k127_7292819_1	1304284.L21TH_0674	3.329e-178	578.0	COG0515@1|root,COG0515@2|Bacteria,1TP3F@1239|Firmicutes,2492G@186801|Clostridia,36DBS@31979|Clostridiaceae	186801|Clostridia	KLT	serine threonine protein kinase	prkC	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
HKD2_k127_7292819_10	1121289.JHVL01000003_gene2284	9.232e-66	233.0	COG0631@1|root,COG0631@2|Bacteria,1V6K5@1239|Firmicutes,24JD4@186801|Clostridia,36F03@31979|Clostridiaceae	186801|Clostridia	T	Phosphatase	stp	-	3.1.3.16	ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C,PP2C_2
HKD2_k127_7292819_3	1415775.U729_2841	2.614e-125	409.0	COG0820@1|root,COG0820@2|Bacteria,1TPVF@1239|Firmicutes,248BC@186801|Clostridia,36E1B@31979|Clostridiaceae	186801|Clostridia	J	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs	rlmN	-	2.1.1.192	ko:K06941	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Fer4_14,Radical_SAM
HKD2_k127_7292819_2	720554.Clocl_2569	8.265e-148	481.0	COG0144@1|root,COG0781@1|root,COG0144@2|Bacteria,COG0781@2|Bacteria,1TP3N@1239|Firmicutes,248CS@186801|Clostridia,3WGKM@541000|Ruminococcaceae	186801|Clostridia	J	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA	sun	-	2.1.1.176	ko:K03500	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltr_RsmB-F,Methyltr_RsmF_N,NusB
HKD2_k127_7292819_7	1304284.L21TH_0670	5.427e-80	272.0	COG2738@1|root,COG2738@2|Bacteria,1TPD3@1239|Firmicutes,2490Y@186801|Clostridia,36FA7@31979|Clostridiaceae	186801|Clostridia	S	zinc metallopeptidase	yugP	-	-	ko:K06973	-	-	-	-	ko00000	-	-	-	Zn_peptidase_2
HKD2_k127_7292819_4	1476973.JMMB01000007_gene919	5.78e-109	360.0	COG0223@1|root,COG0223@2|Bacteria,1TQ32@1239|Firmicutes,248ED@186801|Clostridia,25QKZ@186804|Peptostreptococcaceae	186801|Clostridia	J	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus	fmt	-	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	-	Formyl_trans_C,Formyl_trans_N
HKD2_k127_7292819_12	857293.CAAU_2098	1.824e-57	203.0	COG0242@1|root,COG0242@2|Bacteria,1V70B@1239|Firmicutes,24JET@186801|Clostridia,36IPZ@31979|Clostridiaceae	186801|Clostridia	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions	def	-	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	Pep_deformylase
HKD2_k127_7292819_0	1304284.L21TH_0666	2.163e-237	758.0	COG1198@1|root,COG1198@2|Bacteria,1TNYB@1239|Firmicutes,248EI@186801|Clostridia,36DH7@31979|Clostridiaceae	186801|Clostridia	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	-	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,ResIII
HKD2_k127_7292819_9	509191.AEDB02000099_gene4061	9.051e-72	248.0	COG0652@1|root,COG0652@2|Bacteria,1TRHW@1239|Firmicutes,247XN@186801|Clostridia,3WIPQ@541000|Ruminococcaceae	186801|Clostridia	M	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	-	-	5.2.1.8	ko:K01802,ko:K03768	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Pro_isomerase
HKD2_k127_7292819_8	1033734.CAET01000038_gene204	1.651e-78	274.0	28MW9@1|root,2ZB3J@2|Bacteria,1TRDK@1239|Firmicutes,4HUAT@91061|Bacilli,1ZNSE@1386|Bacillus	91061|Bacilli	S	Protein of unknown function (DUF2812)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2812
HKD2_k127_7435599_2	1511.CLOST_1134	2.641e-06	51.0	COG0183@1|root,COG0183@2|Bacteria,1TP07@1239|Firmicutes,2482I@186801|Clostridia,25R7H@186804|Peptostreptococcaceae	186801|Clostridia	I	Belongs to the thiolase family	phbA	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
HKD2_k127_7435599_0	1121422.AUMW01000006_gene683	1.112e-101	347.0	COG0642@1|root,COG2205@2|Bacteria,1V10X@1239|Firmicutes,24P7E@186801|Clostridia	186801|Clostridia	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
HKD2_k127_7435599_1	1121422.AUMW01000006_gene684	4.896e-85	287.0	COG0745@1|root,COG0745@2|Bacteria,1TPZ0@1239|Firmicutes,2484X@186801|Clostridia,261P1@186807|Peptococcaceae	186801|Clostridia	K	PFAM Response regulator receiver domain	-	-	-	ko:K07775	ko02020,map02020	M00458	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
HKD2_k127_7435599_3	697303.Thewi_0696	0.0002187	46.0	COG4166@1|root,COG4166@2|Bacteria,1TNYQ@1239|Firmicutes,25E4B@186801|Clostridia,42EYF@68295|Thermoanaerobacterales	186801|Clostridia	E	Best Blastp hit gi 98474 pir A38447 oligopeptide ABC transport system substrate-binding protein oppA precursor - Bacillus subtilis gi 143603 gb AAA62687.1 (M57689) sporulation protein Bacillus subtilis gi 2633497 emb CAB13000.1 (Z99110) oligopeptide ABC transporter (binding protein) Bacillus subtilis , score	oppA	-	-	ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	SBP_bac_5
HKD2_k127_74630_0	871968.DESME_05060	0.0	1375.0	COG0474@1|root,COG0474@2|Bacteria,1TPF5@1239|Firmicutes,247JN@186801|Clostridia,260I9@186807|Peptococcaceae	186801|Clostridia	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
HKD2_k127_7502790_4	1511.CLOST_0202	5.283e-16	77.0	28K30@1|root,2Z9SA@2|Bacteria,1TQKJ@1239|Firmicutes,24DSI@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7502790_1	1511.CLOST_0204	9.14e-160	507.0	COG0280@1|root,COG0280@2|Bacteria,1TRQU@1239|Firmicutes,24857@186801|Clostridia,25QX1@186804|Peptostreptococcaceae	186801|Clostridia	C	Phosphate acetyl/butaryl transferase	-	-	2.3.1.19	ko:K00634	ko00650,ko01100,map00650,map01100	-	R01174	RC00004,RC02816	ko00000,ko00001,ko01000	-	-	-	PTA_PTB
HKD2_k127_7502790_0	1511.CLOST_0205	0.0	1127.0	COG4231@1|root,COG4231@2|Bacteria,1TNY3@1239|Firmicutes,247U1@186801|Clostridia,25QVE@186804|Peptostreptococcaceae	186801|Clostridia	C	Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates	iorA	-	1.2.7.8	ko:K00179	-	-	-	-	br01601,ko00000,ko01000	-	-	-	Fer4,Fer4_10,Fer4_6,Fer4_9,POR_N,TPP_enzyme_C
HKD2_k127_7502790_3	350688.Clos_0050	1.954e-31	123.0	COG1014@1|root,COG1014@2|Bacteria,1V1DT@1239|Firmicutes,24HIC@186801|Clostridia,36EAN@31979|Clostridiaceae	186801|Clostridia	C	PFAM pyruvate ferredoxin flavodoxin oxidoreductase	iorB	-	1.2.7.8	ko:K00180	-	-	-	-	br01601,ko00000,ko01000	-	-	-	POR
HKD2_k127_7533673_2	1321778.HMPREF1982_03939	4.019e-119	387.0	COG0013@1|root,COG0013@2|Bacteria,1TPK6@1239|Firmicutes,248M3@186801|Clostridia,267ZC@186813|unclassified Clostridiales	186801|Clostridia	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
HKD2_k127_7533673_5	1321778.HMPREF1982_03938	1.795e-47	171.0	COG4472@1|root,COG4472@2|Bacteria,1VAC4@1239|Firmicutes,24QVQ@186801|Clostridia	186801|Clostridia	S	Belongs to the UPF0297 family	yrzL	-	-	-	-	-	-	-	-	-	-	-	DUF965
HKD2_k127_7533673_4	1321778.HMPREF1982_03937	3.458e-68	233.0	COG0816@1|root,COG0816@2|Bacteria,1V6ER@1239|Firmicutes,24JGP@186801|Clostridia,269MZ@186813|unclassified Clostridiales	186801|Clostridia	L	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA	yrrK	-	-	ko:K07447	-	-	-	-	ko00000,ko01000	-	-	-	RuvX
HKD2_k127_7533673_6	1321778.HMPREF1982_03936	1.722e-36	139.0	COG3906@1|root,COG3906@2|Bacteria,1VF5Z@1239|Firmicutes,24RAZ@186801|Clostridia	186801|Clostridia	S	Belongs to the UPF0473 family	-	-	-	-	-	-	-	-	-	-	-	-	DUF1292
HKD2_k127_7533673_3	1321778.HMPREF1982_03935	1.144e-84	281.0	COG0735@1|root,COG0735@2|Bacteria,1V7F0@1239|Firmicutes,24JQE@186801|Clostridia,269BG@186813|unclassified Clostridiales	186801|Clostridia	P	Ferric uptake regulator family	fur	-	-	ko:K03711	-	-	-	-	ko00000,ko03000	-	-	-	FUR
HKD2_k127_7533673_0	1321778.HMPREF1982_03934	0.0	1020.0	COG0595@1|root,COG0595@2|Bacteria,1TQ9G@1239|Firmicutes,2488J@186801|Clostridia,267N0@186813|unclassified Clostridiales	186801|Clostridia	S	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay	rnj	-	-	ko:K12574	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	Lactamase_B,RMMBL
HKD2_k127_7533673_1	1321778.HMPREF1982_03933	1.566e-210	658.0	COG1217@1|root,COG1217@2|Bacteria,1TQ5Y@1239|Firmicutes,248EB@186801|Clostridia,267S6@186813|unclassified Clostridiales	186801|Clostridia	T	Elongation factor G C-terminus	typA	-	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,EFG_II,GTP_EFTU,GTP_EFTU_D2
HKD2_k127_7533893_0	857293.CAAU_2253	9.098e-299	924.0	COG1328@1|root,COG1328@2|Bacteria,1TR9K@1239|Firmicutes,247WF@186801|Clostridia,36DS9@31979|Clostridiaceae	186801|Clostridia	F	Ribonucleoside-triphosphate reductase	nrdD	-	1.1.98.6	ko:K21636	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R11633,R11634,R11635,R11636	RC00613	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-cone,NRDD
HKD2_k127_7533893_3	1291050.JAGE01000002_gene3826	7.567e-63	220.0	COG0602@1|root,COG0602@2|Bacteria,1V1HG@1239|Firmicutes,24HIJ@186801|Clostridia,3WIVI@541000|Ruminococcaceae	186801|Clostridia	O	Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine	nrdG	-	1.97.1.4	ko:K04068	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
HKD2_k127_7533893_2	1304284.L21TH_2422	3.034e-254	796.0	COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247Q0@186801|Clostridia,36DEY@31979|Clostridiaceae	186801|Clostridia	V	ABC transporter transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
HKD2_k127_7533893_1	1304284.L21TH_2423	6.482e-285	885.0	COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247Q0@186801|Clostridia,36E4P@31979|Clostridiaceae	186801|Clostridia	V	ABC transporter	-	-	-	ko:K06147,ko:K11085,ko:K18888	ko02010,map02010	M00706	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
HKD2_k127_75765_9	1273538.G159_04530	3.688e-23	102.0	2EBSD@1|root,335S8@2|Bacteria,1VFSX@1239|Firmicutes,4HQIK@91061|Bacilli	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_75765_3	1414720.CBYM010000001_gene926	1.503e-140	449.0	COG0708@1|root,COG0708@2|Bacteria,1TPFB@1239|Firmicutes,24849@186801|Clostridia,36E73@31979|Clostridiaceae	186801|Clostridia	L	exodeoxyribonuclease III	xth	-	3.1.11.2	ko:K01142	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exo_endo_phos
HKD2_k127_75765_1	1321778.HMPREF1982_02812	2.536e-174	554.0	COG2211@1|root,COG2211@2|Bacteria,1UKKD@1239|Firmicutes,25GE3@186801|Clostridia	186801|Clostridia	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD2_k127_75765_8	1410653.JHVC01000006_gene230	2.633e-35	141.0	COG1309@1|root,COG1309@2|Bacteria,1VF0Y@1239|Firmicutes,24IZX@186801|Clostridia,36VVE@31979|Clostridiaceae	186801|Clostridia	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
HKD2_k127_75765_0	1487921.DP68_12340	4.107e-217	685.0	COG0477@1|root,COG0477@2|Bacteria,1TPHW@1239|Firmicutes,2492B@186801|Clostridia,36DEV@31979|Clostridiaceae	186801|Clostridia	EGP	TIGRFAM drug resistance transporter, EmrB QacA subfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD2_k127_75765_4	398512.JQKC01000019_gene3453	1.463e-132	432.0	COG1388@1|root,COG1388@2|Bacteria,1UHY7@1239|Firmicutes,24FFK@186801|Clostridia,3WNSB@541000|Ruminococcaceae	186801|Clostridia	M	Lysin motif	-	-	-	-	-	-	-	-	-	-	-	-	LysM
HKD2_k127_75765_5	1487921.DP68_02500	1.736e-92	306.0	COG1396@1|root,COG1917@1|root,COG1396@2|Bacteria,COG1917@2|Bacteria,1V5G6@1239|Firmicutes,24928@186801|Clostridia,36GWJ@31979|Clostridiaceae	186801|Clostridia	K	Helix-turn-helix domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2,HTH_3
HKD2_k127_75765_7	1487921.DP68_02495	1.047e-73	252.0	COG1280@1|root,COG1280@2|Bacteria,1TSNA@1239|Firmicutes,24CNE@186801|Clostridia,36FZM@31979|Clostridiaceae	186801|Clostridia	E	Lysine exporter protein LysE YggA	-	-	-	ko:K11249	-	-	-	-	ko00000,ko02000	2.A.76.1.4	-	-	LysE
HKD2_k127_75765_6	1321778.HMPREF1982_02873	4.646e-74	254.0	COG0778@1|root,COG0778@2|Bacteria,1V4K6@1239|Firmicutes,24B09@186801|Clostridia	186801|Clostridia	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
HKD2_k127_75765_10	1120973.AQXL01000133_gene1796	2.815e-08	55.0	COG0697@1|root,COG0697@2|Bacteria,1TRKE@1239|Firmicutes,4HE64@91061|Bacilli,27A2M@186823|Alicyclobacillaceae	91061|Bacilli	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HKD2_k127_75765_2	484770.UFO1_3837	5.365e-160	512.0	COG0513@1|root,COG0513@2|Bacteria,1TPAP@1239|Firmicutes,4H6XJ@909932|Negativicutes	909932|Negativicutes	L	DbpA RNA binding domain	-	-	3.6.4.13	ko:K05592	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019	-	-	-	DEAD,DbpA,Helicase_C
HKD2_k127_7603265_0	742767.HMPREF9456_02397	3.97e-54	197.0	2DGAP@1|root,2ZV6P@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7603265_1	679190.HMPREF0650_0103	6.078e-37	145.0	2AFQQ@1|root,315SK@2|Bacteria,4NJD4@976|Bacteroidetes,2FURH@200643|Bacteroidia	976|Bacteroidetes	L	NUMOD4 motif	-	-	-	-	-	-	-	-	-	-	-	-	HNH_3,NUMOD4
HKD2_k127_7603265_2	755731.Clo1100_1616	3.038e-14	74.0	COG3935@1|root,COG3935@2|Bacteria,1TQ65@1239|Firmicutes,249Q8@186801|Clostridia,36GNA@31979|Clostridiaceae	186801|Clostridia	L	Phage replisome organizer	-	-	-	-	-	-	-	-	-	-	-	-	DnaB_2,Phage_rep_org_N
HKD2_k127_7662757_1	555079.Toce_0847	3.9e-92	308.0	COG1387@1|root,COG1387@2|Bacteria,1TQ33@1239|Firmicutes,249TZ@186801|Clostridia,42F5D@68295|Thermoanaerobacterales	186801|Clostridia	E	SMART phosphoesterase PHP domain protein	-	-	-	ko:K04477	-	-	-	-	ko00000	-	-	-	PHP
HKD2_k127_7662757_2	1121289.JHVL01000013_gene1631	3.826e-19	90.0	COG1983@1|root,COG1983@2|Bacteria,1VKBQ@1239|Firmicutes,24QU9@186801|Clostridia,36NYT@31979|Clostridiaceae	186801|Clostridia	KT	PspC domain	-	-	-	ko:K03973	-	-	-	-	ko00000,ko02048,ko03000	-	-	-	PspC
HKD2_k127_7662757_0	350688.Clos_2255	8.996e-144	467.0	COG0322@1|root,COG0322@2|Bacteria,1TP4B@1239|Firmicutes,247TQ@186801|Clostridia,36DMH@31979|Clostridiaceae	186801|Clostridia	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	-	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N
HKD2_k127_7692768_0	1304880.JAGB01000003_gene1316	4.029e-80	271.0	COG0542@1|root,COG0542@2|Bacteria,1TPMU@1239|Firmicutes,247TD@186801|Clostridia	186801|Clostridia	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	-	-	-	ko:K03696	ko01100,map01100	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N,UVR
HKD2_k127_7692768_1	1235835.C814_02558	2.171e-09	70.0	COG4932@1|root,COG4932@2|Bacteria,1TQBI@1239|Firmicutes	1239|Firmicutes	M	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cna_B,Collagen_bind,Gram_pos_anchor
HKD2_k127_7697520_1	1321778.HMPREF1982_01277	4.36e-213	669.0	COG0531@1|root,COG0531@2|Bacteria,1TQ48@1239|Firmicutes,248C7@186801|Clostridia,26CPC@186813|unclassified Clostridiales	186801|Clostridia	E	Amino acid permease	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
HKD2_k127_7697520_8	1321778.HMPREF1982_01704	4.905e-75	256.0	COG0655@1|root,COG0655@2|Bacteria,1V1FU@1239|Firmicutes,24FWC@186801|Clostridia	186801|Clostridia	S	PFAM NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
HKD2_k127_7697520_2	398512.JQKC01000028_gene3889	2.792e-206	661.0	COG1368@1|root,COG1368@2|Bacteria,1TRMA@1239|Firmicutes,2480C@186801|Clostridia,3WI05@541000|Ruminococcaceae	186801|Clostridia	M	PFAM sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
HKD2_k127_7697520_14	1410668.JNKC01000003_gene429	2.683e-30	123.0	arCOG05253@1|root,31CTK@2|Bacteria,1VE6F@1239|Firmicutes,24MW8@186801|Clostridia,36KYZ@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7697520_12	272562.CA_C2521	8.132e-36	145.0	29ACM@1|root,2ZXD3@2|Bacteria,1W1XP@1239|Firmicutes,257EZ@186801|Clostridia,36U38@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7697520_9	272562.CA_C2588	7.353e-64	227.0	COG0463@1|root,COG0463@2|Bacteria,1V3ZF@1239|Firmicutes,24INV@186801|Clostridia	186801|Clostridia	M	PFAM Glycosyl transferase family 2	-	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2
HKD2_k127_7697520_4	272562.CA_C2523	1.729e-181	577.0	COG1215@1|root,COG1215@2|Bacteria,1TR2P@1239|Firmicutes,248SW@186801|Clostridia	186801|Clostridia	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_18,Glyco_tranf_2_3,Glycos_transf_2,Polysacc_deac_1
HKD2_k127_7697520_10	272562.CA_C2524	3.235e-58	208.0	290YK@1|root,2ZNKB@2|Bacteria,1V5MF@1239|Firmicutes,24HIN@186801|Clostridia,36J7V@31979|Clostridiaceae	186801|Clostridia	S	Transmembrane exosortase (Exosortase_EpsH)	-	-	-	-	-	-	-	-	-	-	-	-	Exosortase_EpsH
HKD2_k127_7697520_0	272562.CA_C2525	4.95e-282	888.0	COG5617@1|root,COG5617@2|Bacteria,1UXXS@1239|Firmicutes,249CZ@186801|Clostridia,36G7U@31979|Clostridiaceae	186801|Clostridia	H	6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	PTPS,PTPS_related
HKD2_k127_7697520_13	272562.CA_C2526	1.147e-35	139.0	COG0720@1|root,COG0720@2|Bacteria,1VEAX@1239|Firmicutes,24KY7@186801|Clostridia,36KKE@31979|Clostridiaceae	186801|Clostridia	H	6-pyruvoyl tetrahydropterin synthase	-	-	-	-	-	-	-	-	-	-	-	-	PTPS
HKD2_k127_7697520_16	1690.BPSG_1055	0.0001663	49.0	COG2246@1|root,COG2246@2|Bacteria,2HZBR@201174|Actinobacteria,4CZM6@85004|Bifidobacteriales	201174|Actinobacteria	S	GtrA-like protein	-	-	-	-	-	-	-	-	-	-	-	-	GtrA
HKD2_k127_7697520_15	240302.BN982_02395	2.561e-21	93.0	COG0428@1|root,COG0428@2|Bacteria,1TP7J@1239|Firmicutes,4HB3R@91061|Bacilli,3ND78@45667|Halobacillus	91061|Bacilli	P	Zinc transporter ZupT	zupT	-	-	ko:K07238	-	-	-	-	ko00000,ko02000	2.A.5.5	-	-	Zip
HKD2_k127_7697520_5	1196322.A370_01343	1.538e-138	448.0	COG0679@1|root,COG0679@2|Bacteria,1TXY4@1239|Firmicutes,24CXJ@186801|Clostridia,36HDZ@31979|Clostridiaceae	186801|Clostridia	S	Membrane transport protein	-	-	-	ko:K07088	-	-	-	-	ko00000	-	-	-	Mem_trans
HKD2_k127_7697520_3	1321778.HMPREF1982_01571	3.472e-183	580.0	COG0462@1|root,COG0462@2|Bacteria,1TQ6Q@1239|Firmicutes,248ZN@186801|Clostridia	186801|Clostridia	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	prs	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyl_synth,Pribosyltran,Pribosyltran_N
HKD2_k127_7697520_7	332101.JIBU02000047_gene3554	7.072e-88	302.0	COG0322@1|root,COG0322@2|Bacteria,1V175@1239|Firmicutes,24ATK@186801|Clostridia,36F0U@31979|Clostridiaceae	186801|Clostridia	L	Excinuclease ABC C subunit domain protein	uvrC2	-	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,UVR
HKD2_k127_7697520_6	1321778.HMPREF1982_02656	3.611e-111	366.0	COG0053@1|root,COG0053@2|Bacteria,1TSGY@1239|Firmicutes,2491V@186801|Clostridia,268DI@186813|unclassified Clostridiales	186801|Clostridia	P	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,ZT_dimer
HKD2_k127_7697520_11	1195236.CTER_5081	6.435e-48	174.0	2D5AS@1|root,32TIN@2|Bacteria,1VA4E@1239|Firmicutes,24JJQ@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7706405_1	1408422.JHYF01000004_gene1654	1.808e-176	562.0	COG0312@1|root,COG0312@2|Bacteria,1TSQC@1239|Firmicutes,248MD@186801|Clostridia,36F5C@31979|Clostridiaceae	186801|Clostridia	S	modulator of DNA gyrase	-	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
HKD2_k127_7706405_3	1408422.JHYF01000004_gene1655	1.038e-151	491.0	COG0312@1|root,COG0312@2|Bacteria,1TQJ5@1239|Firmicutes,24AGW@186801|Clostridia,36DQ8@31979|Clostridiaceae	186801|Clostridia	S	peptidase U62, modulator of DNA gyrase	-	-	-	ko:K03592	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
HKD2_k127_7706405_2	857293.CAAU_0665	2.016e-154	495.0	COG0016@1|root,COG0016@2|Bacteria,1TPFW@1239|Firmicutes,2486E@186801|Clostridia,36DSH@31979|Clostridiaceae	186801|Clostridia	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily	pheS	-	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Phe_tRNA-synt_N,tRNA-synt_2d
HKD2_k127_7706405_0	203119.Cthe_0215	4.197e-266	839.0	COG0072@1|root,COG0072@2|Bacteria,1TP98@1239|Firmicutes,248BJ@186801|Clostridia,3WHBB@541000|Ruminococcaceae	186801|Clostridia	J	phenylalanyl-tRNA synthetase (beta subunit)	pheT	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,tRNA-synt_2d,tRNA_bind
HKD2_k127_7746137_0	580331.Thit_1713	0.0	1259.0	COG0383@1|root,COG0383@2|Bacteria,1TQEH@1239|Firmicutes,248VH@186801|Clostridia,42FU3@68295|Thermoanaerobacterales	186801|Clostridia	G	glycosyl hydrolase 38 domain protein	-	-	3.2.1.24	ko:K01191	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04131	-	GH38	-	Alpha-mann_mid,Glyco_hydro_38,Glyco_hydro_38C
HKD2_k127_7746137_2	555079.Toce_1961	4.804e-51	184.0	COG1733@1|root,COG1733@2|Bacteria,1VCB0@1239|Firmicutes,25CMG@186801|Clostridia	186801|Clostridia	K	PFAM helix-turn-helix HxlR type	-	-	-	-	-	-	-	-	-	-	-	-	HxlR
HKD2_k127_7746137_1	1295642.H839_08744	2.615e-83	280.0	COG0454@1|root,COG0456@2|Bacteria,1V1MF@1239|Firmicutes,4HGE9@91061|Bacilli	91061|Bacilli	K	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HKD2_k127_7746137_3	748727.CLJU_c30300	3.786e-37	140.0	COG0407@1|root,COG0407@2|Bacteria,1USM0@1239|Firmicutes,248G3@186801|Clostridia,36EEG@31979|Clostridiaceae	186801|Clostridia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
HKD2_k127_7746349_4	981383.AEWH01000063_gene1950	4.052e-28	126.0	COG0640@1|root,COG0640@2|Bacteria,1VIR8@1239|Firmicutes,4HPZ0@91061|Bacilli	91061|Bacilli	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
HKD2_k127_7746349_3	649747.HMPREF0083_03706	2.471e-96	320.0	COG1187@1|root,COG1187@2|Bacteria,1TQZ2@1239|Firmicutes,4H9VU@91061|Bacilli,26QQ0@186822|Paenibacillaceae	91061|Bacilli	J	Belongs to the pseudouridine synthase RsuA family	rsuA	GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360	5.4.99.19	ko:K06183	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
HKD2_k127_7746349_0	1304284.L21TH_0079	0.0	1817.0	COG1057@1|root,COG1057@2|Bacteria,1TQVJ@1239|Firmicutes,249M0@186801|Clostridia,36DM4@31979|Clostridiaceae	186801|Clostridia	H	Cytidylyltransferase-like	-	-	-	-	-	-	-	-	-	-	-	-	CTP_transf_like
HKD2_k127_7746349_1	1304284.L21TH_0080	1.617e-142	464.0	COG0039@1|root,COG0039@2|Bacteria,1TQIV@1239|Firmicutes,248DK@186801|Clostridia,36GJF@31979|Clostridiaceae	186801|Clostridia	C	lactate/malate dehydrogenase, NAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Ldh_1_N
HKD2_k127_7746349_2	1408422.JHYF01000003_gene789	1.322e-109	364.0	COG0431@1|root,COG0431@2|Bacteria,1UYKJ@1239|Firmicutes,2485E@186801|Clostridia,36E7N@31979|Clostridiaceae	186801|Clostridia	S	NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
HKD2_k127_7746349_6	1410653.JHVC01000018_gene2285	1.657e-06	51.0	COG1404@1|root,COG1404@2|Bacteria,1VD5C@1239|Firmicutes,24C2E@186801|Clostridia,36H8D@31979|Clostridiaceae	186801|Clostridia	O	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
HKD2_k127_7746349_5	857293.CAAU_0628	1.817e-16	79.0	COG0334@1|root,COG0334@2|Bacteria,1TP45@1239|Firmicutes,24960@186801|Clostridia,36EGU@31979|Clostridiaceae	186801|Clostridia	E	Belongs to the Glu Leu Phe Val dehydrogenases family	gdhA	-	1.4.1.3,1.4.1.4	ko:K00261,ko:K00262	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
HKD2_k127_7785888_0	1321778.HMPREF1982_00535	1.263e-316	972.0	COG0542@1|root,COG0542@2|Bacteria,1TPMU@1239|Firmicutes,247TD@186801|Clostridia,2680Z@186813|unclassified Clostridiales	186801|Clostridia	O	Belongs to the ClpA ClpB family	clpC	-	-	ko:K03696	ko01100,map01100	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N,UVR
HKD2_k127_7813418_3	1410653.JHVC01000027_gene1069	2.365e-46	168.0	COG2267@1|root,COG2267@2|Bacteria,1TPI0@1239|Firmicutes,247QR@186801|Clostridia,36F4I@31979|Clostridiaceae	186801|Clostridia	I	Alpha beta hydrolase	-	-	1.11.1.10,3.1.1.24	ko:K00433,ko:K01055	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00568	R02991	RC00825	ko00000,ko00001,ko00002,ko01000	-	-	-	Abhydrolase_1,Abhydrolase_4
HKD2_k127_7813418_1	1262449.CP6013_1270	1.123e-81	285.0	COG2199@1|root,COG3706@2|Bacteria,1V2QN@1239|Firmicutes,249KZ@186801|Clostridia,36VH6@31979|Clostridiaceae	186801|Clostridia	T	TIGRFAM Diguanylate cyclase	-	-	2.7.7.65	ko:K18967	-	-	-	-	ko00000,ko01000,ko02000	9.B.34.1.1	-	-	5TM-5TMR_LYT,GGDEF
HKD2_k127_7813418_2	332101.JIBU02000048_gene3672	1.133e-79	269.0	COG0454@1|root,COG0456@2|Bacteria,1VHDN@1239|Firmicutes,24FXK@186801|Clostridia,36WBJ@31979|Clostridiaceae	186801|Clostridia	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HKD2_k127_7813418_0	1195236.CTER_5073	1.584e-101	340.0	COG0604@1|root,COG0604@2|Bacteria,1TT5J@1239|Firmicutes,24IEA@186801|Clostridia,3WPYS@541000|Ruminococcaceae	186801|Clostridia	C	alcohol dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7820627_7	1340434.AXVA01000040_gene198	3.991e-10	60.0	COG0206@1|root,COG0206@2|Bacteria,1TP6W@1239|Firmicutes,4H9WZ@91061|Bacilli,1ZDE2@1386|Bacillus	91061|Bacilli	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0032153,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0051301,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
HKD2_k127_7820627_4	1121289.JHVL01000030_gene413	2.381e-42	158.0	COG3856@1|root,COG3856@2|Bacteria,1VA6N@1239|Firmicutes,24N58@186801|Clostridia,36JGG@31979|Clostridiaceae	186801|Clostridia	S	small basic protein	sbp	-	-	-	-	-	-	-	-	-	-	-	DUF1290
HKD2_k127_7820627_3	273068.TTE1642	1.019e-44	171.0	COG3879@1|root,COG3879@2|Bacteria,1V0FG@1239|Firmicutes,24DRC@186801|Clostridia,42G46@68295|Thermoanaerobacterales	186801|Clostridia	S	Bacterial protein of unknown function (DUF881)	-	-	-	-	-	-	-	-	-	-	-	-	DUF881
HKD2_k127_7820627_2	340099.Teth39_0816	7.331e-51	188.0	COG3879@1|root,COG3879@2|Bacteria,1V66C@1239|Firmicutes,2492Y@186801|Clostridia,42JD3@68295|Thermoanaerobacterales	186801|Clostridia	S	Bacterial protein of unknown function (DUF881)	-	-	-	-	-	-	-	-	-	-	-	-	DUF881
HKD2_k127_7820627_5	1286171.EAL2_c10490	2.202e-32	135.0	COG1589@1|root,COG1589@2|Bacteria,1VG7K@1239|Firmicutes,25MVP@186801|Clostridia,25XQE@186806|Eubacteriaceae	186801|Clostridia	D	Cell division protein FtsQ	-	-	-	ko:K03589	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036	-	-	-	POTRA_1
HKD2_k127_7820627_0	1121289.JHVL01000030_gene409	1.023e-124	406.0	COG0766@1|root,COG0766@2|Bacteria,1TPAU@1239|Firmicutes,2488W@186801|Clostridia,36DC0@31979|Clostridiaceae	186801|Clostridia	M	Belongs to the EPSP synthase family. MurA subfamily	murA2	-	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase
HKD2_k127_7820627_1	398512.JQKC01000012_gene278	2.682e-114	387.0	COG1961@1|root,COG1961@2|Bacteria,1TPA6@1239|Firmicutes,247KF@186801|Clostridia,3WI42@541000|Ruminococcaceae	186801|Clostridia	KL	Recombinase zinc beta ribbon domain	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,SpoVT_C,Zn_ribbon_recom
HKD2_k127_7820627_8	1449063.JMLS01000053_gene2965	3.538e-06	56.0	COG1396@1|root,COG1396@2|Bacteria,1VK84@1239|Firmicutes,4HRBT@91061|Bacilli,277E8@186822|Paenibacillaceae	91061|Bacilli	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	HTH_19,HTH_3
HKD2_k127_7820627_6	293826.Amet_2878	4.266e-15	77.0	COG0766@1|root,COG0766@2|Bacteria,1TPAU@1239|Firmicutes,2488W@186801|Clostridia,36DC0@31979|Clostridiaceae	186801|Clostridia	M	Belongs to the EPSP synthase family. MurA subfamily	murA2	-	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase
HKD2_k127_7823698_2	373903.Hore_10150	9.222e-62	221.0	COG3314@1|root,COG3314@2|Bacteria,1TR0V@1239|Firmicutes,247XA@186801|Clostridia,3WAZS@53433|Halanaerobiales	186801|Clostridia	S	TIGRFAM sporulation integral membrane protein YlbJ	ylbJ	-	-	-	-	-	-	-	-	-	-	-	Gate
HKD2_k127_7823698_1	857293.CAAU_2471	1.015e-103	352.0	COG1323@1|root,COG1323@2|Bacteria,1TPP2@1239|Firmicutes,247UP@186801|Clostridia,36DM0@31979|Clostridiaceae	186801|Clostridia	S	Belongs to the UPF0348 family	-	-	-	-	-	-	-	-	-	-	-	-	HIGH_NTase1
HKD2_k127_7823698_0	941824.TCEL_01823	8.966e-188	593.0	COG0282@1|root,COG0282@2|Bacteria,1TQ22@1239|Firmicutes,248ZM@186801|Clostridia,36EE0@31979|Clostridiaceae	186801|Clostridia	F	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction	ackA	GO:0006082,GO:0006083,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016053,GO:0016999,GO:0017000,GO:0017144,GO:0019413,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:0072330,GO:1901576	2.7.2.1	ko:K00925	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00315,R01353	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetate_kinase
HKD2_k127_7823698_3	1410668.JNKC01000001_gene1294	5.495e-24	108.0	COG1399@1|root,COG1399@2|Bacteria,1VEXU@1239|Firmicutes,24RKT@186801|Clostridia,36JU8@31979|Clostridiaceae	186801|Clostridia	S	Uncharacterized ACR, COG1399	-	-	-	ko:K07040	-	-	-	-	ko00000	-	-	-	DUF177
HKD2_k127_7823698_4	1069080.KB913028_gene984	8.504e-21	94.0	COG0333@1|root,COG0333@2|Bacteria,1VEFI@1239|Firmicutes,4H5MV@909932|Negativicutes	909932|Negativicutes	J	Belongs to the bacterial ribosomal protein bL32 family	rpmF	-	-	ko:K02911	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_L32p
HKD2_k127_7835434_6	1487921.DP68_10530	2.771e-61	214.0	COG2035@1|root,COG2035@2|Bacteria,1UYD5@1239|Firmicutes,24B08@186801|Clostridia,36G4J@31979|Clostridiaceae	186801|Clostridia	S	Domain of unknown function (DUF368)	-	-	-	ko:K08974	-	-	-	-	ko00000	-	-	-	DUF368
HKD2_k127_7835434_2	484770.UFO1_3144	3.238e-185	580.0	COG1082@1|root,COG1082@2|Bacteria,1TPJT@1239|Firmicutes	1239|Firmicutes	G	Xylose isomerase	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2,AP_endonuc_2_N
HKD2_k127_7835434_3	484770.UFO1_3145	4.625e-185	582.0	COG0673@1|root,COG0673@2|Bacteria,1TRHA@1239|Firmicutes,4H3TC@909932|Negativicutes	909932|Negativicutes	S	Involved in the oxidation of myo-inositol (MI) and D- chiro-inositol (DCI) to 2-keto-myo-inositol (2KMI or 2-inosose) and 1-keto-D-chiro-inositol (1KDCI), respectively	iolG	-	1.1.1.18,1.1.1.369	ko:K00010	ko00521,ko00562,ko01100,ko01120,ko01130,map00521,map00562,map01100,map01120,map01130	-	R01183,R09951	RC00182	ko00000,ko00001,ko01000	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
HKD2_k127_7835434_4	1121342.AUCO01000008_gene105	2.165e-75	263.0	COG2207@1|root,COG2207@2|Bacteria,1TQ2W@1239|Firmicutes,24A5W@186801|Clostridia,36VIU@31979|Clostridiaceae	186801|Clostridia	K	AraC-like ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	AraC_binding,Cupin_2,HTH_18,HTH_AraC
HKD2_k127_7835434_1	1321778.HMPREF1982_01119	2.266e-199	623.0	COG0180@1|root,COG0180@2|Bacteria,1TPY7@1239|Firmicutes,248RC@186801|Clostridia,267IZ@186813|unclassified Clostridiales	186801|Clostridia	J	tRNA synthetases class I (W and Y)	trpS	-	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
HKD2_k127_7835434_5	1196322.A370_04802	9.552e-66	226.0	COG2033@1|root,COG2033@2|Bacteria,1VA34@1239|Firmicutes,24J9I@186801|Clostridia,36JYV@31979|Clostridiaceae	186801|Clostridia	C	Desulfoferrodoxin ferrous iron-binding	dfx	GO:0000302,GO:0000303,GO:0000305,GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0006091,GO:0006801,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009055,GO:0009636,GO:0009987,GO:0010035,GO:0016491,GO:0016721,GO:0019430,GO:0022900,GO:0033554,GO:0034599,GO:0034614,GO:0042221,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0071450,GO:0071451,GO:0072593,GO:0097237,GO:0098754,GO:0098869,GO:1901700,GO:1901701,GO:1990748	1.15.1.2	ko:K05919	-	-	-	-	ko00000,ko01000	-	-	-	Desulfoferrod_N,Desulfoferrodox
HKD2_k127_7835434_0	1321778.HMPREF1982_01117	0.0	1615.0	COG3459@1|root,COG3459@2|Bacteria,1TQY8@1239|Firmicutes,248YP@186801|Clostridia	186801|Clostridia	G	Glycosyltransferase 36 associated	ndvB	-	-	-	-	-	-	-	-	-	-	-	DUF3131,Glyco_hydro_36,Glyco_transf_36,Glycoamylase
HKD2_k127_783674_0	1321778.HMPREF1982_04167	1.015e-150	480.0	COG0416@1|root,COG0416@2|Bacteria,1TPY8@1239|Firmicutes,248BX@186801|Clostridia	186801|Clostridia	I	Fatty acid	grdD	-	1.21.4.2,1.21.4.3,1.21.4.4	ko:K21576	-	-	-	-	ko00000,ko01000	-	-	-	FA_synthesis
HKD2_k127_783674_1	1321778.HMPREF1982_04166	9.339e-85	285.0	COG1744@1|root,COG1744@2|Bacteria,1TPEU@1239|Firmicutes,248QT@186801|Clostridia,26875@186813|unclassified Clostridiales	186801|Clostridia	S	ABC transporter substrate-binding protein PnrA-like	-	-	-	ko:K07335	-	-	-	-	ko00000	-	-	-	Bmp
HKD2_k127_7844195_1	768704.Desmer_0850	1.816e-55	199.0	COG1595@1|root,COG1595@2|Bacteria,1VBIF@1239|Firmicutes,24P38@186801|Clostridia,2661A@186807|Peptococcaceae	186801|Clostridia	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD2_k127_7844195_2	646529.Desaci_1054	3.029e-49	183.0	2E77V@1|root,331RK@2|Bacteria,1TSI0@1239|Firmicutes,24T06@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7844195_4	1499685.CCFJ01000046_gene3047	1.792e-06	50.0	2AWWS@1|root,31NUA@2|Bacteria,1TZQC@1239|Firmicutes,4II4H@91061|Bacilli,1ZKNB@1386|Bacillus	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7844195_3	1121423.JONT01000013_gene306	5.133e-25	107.0	COG4392@1|root,COG4392@2|Bacteria	2|Bacteria	E	branched-chain amino acid	azlD	-	-	-	-	-	-	-	-	-	-	-	AzlD
HKD2_k127_7844195_0	1120973.AQXL01000133_gene1799	2.269e-90	302.0	COG1296@1|root,COG1296@2|Bacteria,1TSXD@1239|Firmicutes,4HJCQ@91061|Bacilli	91061|Bacilli	E	branched-chain amino acid	-	-	-	-	-	-	-	-	-	-	-	-	AzlC
HKD2_k127_7874535_5	293826.Amet_2067	1.017e-52	191.0	COG3653@1|root,COG3653@2|Bacteria,1TSGD@1239|Firmicutes,2482F@186801|Clostridia,36GAD@31979|Clostridiaceae	186801|Clostridia	Q	N-acyl-D-aspartate D-glutamate deacylase	-	-	3.5.1.81	ko:K06015	-	-	R02192	RC00064,RC00328	ko00000,ko01000	-	-	-	Amidohydro_1,Amidohydro_3
HKD2_k127_7874535_0	865861.AZSU01000004_gene1031	4.59e-151	489.0	COG0019@1|root,COG0019@2|Bacteria,1TPE9@1239|Firmicutes,247X7@186801|Clostridia,36FIT@31979|Clostridiaceae	186801|Clostridia	E	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine	lysA	-	4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
HKD2_k127_7874535_1	555079.Toce_0661	6.32e-148	474.0	COG0444@1|root,COG0444@2|Bacteria,1TP6E@1239|Firmicutes,247NN@186801|Clostridia,42F1U@68295|Thermoanaerobacterales	186801|Clostridia	P	Belongs to the ABC transporter superfamily	oppD	-	-	ko:K15583	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
HKD2_k127_7874535_3	555079.Toce_0660	9.304e-125	406.0	COG1173@1|root,COG1173@2|Bacteria,1TP4R@1239|Firmicutes,2489T@186801|Clostridia,42F60@68295|Thermoanaerobacterales	186801|Clostridia	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02034,ko:K15582	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	BPD_transp_1,OppC_N
HKD2_k127_7874535_2	340099.Teth39_1688	8.854e-129	417.0	COG0601@1|root,COG0601@2|Bacteria,1TP1S@1239|Firmicutes,247IP@186801|Clostridia,42FJK@68295|Thermoanaerobacterales	186801|Clostridia	P	PFAM binding-protein-dependent transport systems inner membrane component	oppB	-	-	ko:K15581	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	BPD_transp_1
HKD2_k127_7874535_4	1487921.DP68_16650	1.441e-108	355.0	COG1143@1|root,COG1143@2|Bacteria,1UI2X@1239|Firmicutes,25EBS@186801|Clostridia,36UJQ@31979|Clostridiaceae	186801|Clostridia	C	binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_4,Fer4_9,Flavodoxin_5
HKD2_k127_7895892_6	1163671.JAGI01000002_gene2230	2.342e-29	119.0	COG3467@1|root,COG3467@2|Bacteria,1V7MR@1239|Firmicutes,25B09@186801|Clostridia,36W93@31979|Clostridiaceae	186801|Clostridia	S	Pyridoxamine 5'-phosphate oxidase	-	-	-	ko:K07005	-	-	-	-	ko00000	-	-	-	Pyridox_ox_2
HKD2_k127_7895892_2	1408422.JHYF01000009_gene2132	1.309e-62	224.0	COG1376@1|root,COG3409@1|root,COG1376@2|Bacteria,COG3409@2|Bacteria,1TQAB@1239|Firmicutes,24ESH@186801|Clostridia,36JPX@31979|Clostridiaceae	186801|Clostridia	M	L,D-transpeptidase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_1,YkuD
HKD2_k127_7895892_1	1304284.L21TH_1411	5.445e-162	524.0	COG0308@1|root,COG0308@2|Bacteria,1U6PC@1239|Firmicutes,24AYS@186801|Clostridia,36F7X@31979|Clostridiaceae	186801|Clostridia	E	PFAM Peptidase M1, membrane alanine	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M1
HKD2_k127_7895892_4	1211817.CCAT010000085_gene2044	9.834e-42	154.0	COG2158@1|root,COG2158@2|Bacteria,1VFNA@1239|Firmicutes,24MYB@186801|Clostridia,36KH3@31979|Clostridiaceae	186801|Clostridia	S	Cysteine-rich small domain	-	-	-	ko:K07162	-	-	-	-	ko00000	-	-	-	zf-like
HKD2_k127_7895892_0	720554.Clocl_1089	4.548e-251	779.0	COG0017@1|root,COG0017@2|Bacteria,1TP38@1239|Firmicutes,2484D@186801|Clostridia,3WGDY@541000|Ruminococcaceae	186801|Clostridia	J	asparaginyl-tRNA synthetase	asnS	-	6.1.1.22	ko:K01893	ko00970,map00970	M00359,M00360	R03648	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
HKD2_k127_7895892_3	1121335.Clst_1137	2.42e-44	183.0	COG2041@1|root,COG2340@1|root,COG2041@2|Bacteria,COG2340@2|Bacteria,1V1IM@1239|Firmicutes,24GB5@186801|Clostridia,3WJC0@541000|Ruminococcaceae	186801|Clostridia	N	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	CAP,SLH
HKD2_k127_7895892_8	931276.Cspa_c20080	2.372e-18	100.0	COG2247@1|root,COG3291@1|root,COG4447@1|root,COG4932@1|root,COG5263@1|root,COG2247@2|Bacteria,COG3291@2|Bacteria,COG4447@2|Bacteria,COG4932@2|Bacteria,COG5263@2|Bacteria,1VCI4@1239|Firmicutes,24CF6@186801|Clostridia,36N4E@31979|Clostridiaceae	186801|Clostridia	M	repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	Cu_amine_oxidN1,N_methyl
HKD2_k127_7895892_5	1121335.Clst_0437	1.217e-41	175.0	COG0265@1|root,COG0265@2|Bacteria,1UY9N@1239|Firmicutes,24E52@186801|Clostridia	186801|Clostridia	O	Belongs to the glycosyl hydrolase 43 family	-	-	-	-	-	-	-	-	-	-	-	-	SLH
HKD2_k127_7895892_7	573061.Clocel_2056	2.787e-26	109.0	COG0015@1|root,COG0015@2|Bacteria,1TPMM@1239|Firmicutes,2485N@186801|Clostridia,36DRK@31979|Clostridiaceae	186801|Clostridia	F	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily	purB	-	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	-	ADSL_C,Lyase_1
HKD2_k127_7919599_1	1321778.HMPREF1982_00216	8.697e-91	304.0	COG0642@1|root,COG2205@2|Bacteria,1TQMV@1239|Firmicutes,247SE@186801|Clostridia,26ATW@186813|unclassified Clostridiales	186801|Clostridia	T	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_9,PocR
HKD2_k127_7919599_0	646529.Desaci_2422	8.13e-205	663.0	COG3322@1|root,COG3437@1|root,COG3322@2|Bacteria,COG3437@2|Bacteria,1TQ0S@1239|Firmicutes,25F8N@186801|Clostridia,2610P@186807|Peptococcaceae	186801|Clostridia	T	TIGRFAM PAS domain S-box	-	-	-	-	-	-	-	-	-	-	-	-	CHASE4,GGDEF,HD_5,PAS_3,PAS_4
HKD2_k127_7919599_2	1286171.EAL2_c06720	1.128e-23	101.0	2E0JW@1|root,32W5C@2|Bacteria,1VBNI@1239|Firmicutes,24J6D@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7925301_3	720554.Clocl_3430	8.588e-79	273.0	COG0330@1|root,COG0330@2|Bacteria,1TR6S@1239|Firmicutes,24A7V@186801|Clostridia,3WI4M@541000|Ruminococcaceae	186801|Clostridia	O	prohibitin homologues	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
HKD2_k127_7925301_1	697281.Mahau_1497	3.424e-107	358.0	COG1674@1|root,COG1674@2|Bacteria,1UIE4@1239|Firmicutes,25EJ8@186801|Clostridia,42FPQ@68295|Thermoanaerobacterales	186801|Clostridia	D	ftsk spoiiie	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7925301_4	1128398.Curi_c03740	2.116e-42	164.0	2CDRC@1|root,32WTE@2|Bacteria,1VFV7@1239|Firmicutes,24B1R@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7925301_0	484770.UFO1_3142	1.08e-146	470.0	COG1052@1|root,COG1052@2|Bacteria,1TPCX@1239|Firmicutes,4H24H@909932|Negativicutes	909932|Negativicutes	C	PFAM D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein, D-isomer specific 2-hydroxyacid dehydrogenase catalytic region-containing protein	-	-	1.1.1.29	ko:K00018	ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200	M00346	R00717,R01388	RC00031,RC00042	ko00000,ko00001,ko00002,ko01000	-	-	-	2-Hacid_dh,2-Hacid_dh_C
HKD2_k127_7925301_5	1304880.JAGB01000002_gene2412	1.79e-37	142.0	COG2002@1|root,COG2002@2|Bacteria,1VA3H@1239|Firmicutes,24MN7@186801|Clostridia	186801|Clostridia	K	Transcriptional regulator, AbrB family	abrB	-	-	ko:K06284	-	-	-	-	ko00000,ko03000	-	-	-	MazE_antitoxin
HKD2_k127_7925301_6	457570.Nther_1788	5.33e-17	83.0	COG2846@1|root,COG2846@2|Bacteria,1VET8@1239|Firmicutes,24QPY@186801|Clostridia	186801|Clostridia	D	cluster protein-associated redox disulfide domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF1858
HKD2_k127_7925301_2	1128398.Curi_c01180	3.333e-101	337.0	COG0313@1|root,COG0313@2|Bacteria,1TP6U@1239|Firmicutes,24864@186801|Clostridia,267QY@186813|unclassified Clostridiales	186801|Clostridia	H	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA	rsmI	-	2.1.1.198	ko:K07056	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TP_methylase
HKD2_k127_7925301_7	394503.Ccel_0162	1.046e-12	68.0	COG4123@1|root,COG4123@2|Bacteria,1TQ25@1239|Firmicutes,249UH@186801|Clostridia,36F66@31979|Clostridiaceae	186801|Clostridia	S	Methyltransferase	yfiC	-	2.1.1.223	ko:K15460	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	MTS,Methyltransf_31
HKD2_k127_7926265_1	1443122.Z958_01885	3.07e-137	440.0	COG1191@1|root,COG1191@2|Bacteria,1TPDD@1239|Firmicutes,24A1H@186801|Clostridia,36E0E@31979|Clostridiaceae	186801|Clostridia	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	sigG	-	-	ko:K03091	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r3,Sigma70_r4
HKD2_k127_7926265_2	1408422.JHYF01000002_gene2533	1.732e-115	376.0	COG1191@1|root,COG1191@2|Bacteria,1TP3T@1239|Firmicutes,24A4T@186801|Clostridia,36E4R@31979|Clostridiaceae	186801|Clostridia	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	sigE	-	-	ko:K03091	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4
HKD2_k127_7926265_3	293826.Amet_2872	2.986e-70	248.0	29ECG@1|root,301AF@2|Bacteria,1UY4W@1239|Firmicutes,24HI3@186801|Clostridia,36JFC@31979|Clostridiaceae	186801|Clostridia	M	aspartic protease that is responsible for the proteolytic cleavage of the RNA polymerase sigma E factor (SigE spoIIGB) to yield the active peptide in the mother cell during sporulation. Responds to a signal from the forespore that is triggered by the extracellular signal protein SpoIIR	spoIIGA	-	-	ko:K06383	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_U4
HKD2_k127_7926265_0	203119.Cthe_0445	2.263e-160	512.0	COG0206@1|root,COG0206@2|Bacteria,1TP6W@1239|Firmicutes,247Z5@186801|Clostridia,3WH3G@541000|Ruminococcaceae	186801|Clostridia	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
HKD2_k127_7946944_0	1476973.JMMB01000007_gene916	4.135e-105	346.0	COG0452@1|root,COG0452@2|Bacteria,1TPP3@1239|Firmicutes,247J3@186801|Clostridia,25QR8@186804|Peptostreptococcaceae	186801|Clostridia	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	coaBC	-	4.1.1.36,6.3.2.5	ko:K01598,ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	DFP,Flavoprotein
HKD2_k127_7946944_5	398512.JQKC01000012_gene186	1.362e-18	88.0	COG1758@1|root,COG1758@2|Bacteria,1UQDG@1239|Firmicutes,2584A@186801|Clostridia,3WKRR@541000|Ruminococcaceae	186801|Clostridia	K	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits	rpoZ	-	2.7.7.6	ko:K03060	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb6
HKD2_k127_7946944_2	1345695.CLSA_c13620	2.816e-73	251.0	COG0194@1|root,COG0194@2|Bacteria,1TP0M@1239|Firmicutes,24HEX@186801|Clostridia,36EVE@31979|Clostridiaceae	186801|Clostridia	F	Essential for recycling GMP and indirectly, cGMP	gmk	-	2.7.4.8	ko:K00942	ko00230,ko01100,map00230,map01100	M00050	R00332,R02090	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_kin
HKD2_k127_7946944_4	1487921.DP68_06195	4.13e-43	159.0	COG2052@1|root,COG2052@2|Bacteria,1VA40@1239|Firmicutes,24MXV@186801|Clostridia,36JMX@31979|Clostridiaceae	186801|Clostridia	S	Belongs to the UPF0296 family	NPD7_560	-	-	ko:K09777	-	-	-	-	ko00000	-	-	-	DUF370
HKD2_k127_7946944_1	203119.Cthe_1317	3.38e-90	305.0	COG1561@1|root,COG1561@2|Bacteria,1TQHJ@1239|Firmicutes,24824@186801|Clostridia,3WNGU@541000|Ruminococcaceae	186801|Clostridia	S	Domain of unknown function (DUF1732)	yicC	-	-	-	-	-	-	-	-	-	-	-	DUF1732,YicC_N
HKD2_k127_7946944_3	608506.COB47_1896	7.116e-69	240.0	COG0253@1|root,COG0253@2|Bacteria,1TPMN@1239|Firmicutes,24AGY@186801|Clostridia,42F7U@68295|Thermoanaerobacterales	186801|Clostridia	E	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan	dapF	-	5.1.1.7	ko:K01778	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00527	R02735	RC00302	ko00000,ko00001,ko00002,ko01000	-	-	-	DAP_epimerase
HKD2_k127_7977457_0	1123288.SOV_6c01920	2.178e-248	790.0	COG1067@1|root,COG1067@2|Bacteria,1TQT5@1239|Firmicutes,4H23V@909932|Negativicutes	909932|Negativicutes	O	Belongs to the peptidase S16 family	-	-	-	-	-	-	-	-	-	-	-	-	AAA_32,Lon_C
HKD2_k127_7977457_3	332101.JIBU02000004_gene146	8.289e-122	411.0	COG0840@1|root,COG0840@2|Bacteria,1U3C3@1239|Firmicutes,25AZR@186801|Clostridia	186801|Clostridia	NT	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer).	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	MCPsignal,dCache_1
HKD2_k127_7977457_6	1236976.JCM16418_1118	1.17e-70	247.0	COG0584@1|root,COG0584@2|Bacteria,1V3W4@1239|Firmicutes,4HFNQ@91061|Bacilli,26SCR@186822|Paenibacillaceae	91061|Bacilli	C	glycerophosphoryl diester phosphodiesterase	yqiK	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD
HKD2_k127_7977457_2	521045.Kole_1041	7.028e-128	420.0	COG2211@1|root,COG2211@2|Bacteria,2GCM3@200918|Thermotogae	200918|Thermotogae	G	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD2_k127_7977457_7	189425.PGRAT_13305	2.461e-54	199.0	COG0775@1|root,COG0775@2|Bacteria,1U7WK@1239|Firmicutes,4HB8K@91061|Bacilli,26TU4@186822|Paenibacillaceae	91061|Bacilli	E	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively	mtnN	-	3.2.2.9	ko:K01243	ko00270,ko01100,ko01230,map00270,map01100,map01230	M00034,M00609	R00194,R01401	RC00063,RC00318	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
HKD2_k127_7977457_4	1196322.A370_05853	3.032e-88	307.0	COG0457@1|root,COG1396@1|root,COG0457@2|Bacteria,COG1396@2|Bacteria,1UYX5@1239|Firmicutes,24HYD@186801|Clostridia,36PG5@31979|Clostridiaceae	186801|Clostridia	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	HTH_19
HKD2_k127_7977457_5	350688.Clos_2353	5.228e-88	306.0	COG0477@1|root,COG0477@2|Bacteria,1UHXP@1239|Firmicutes,25335@186801|Clostridia,36UMT@31979|Clostridiaceae	186801|Clostridia	EGP	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_3
HKD2_k127_7977457_1	1499689.CCNN01000007_gene1590	4.122e-206	654.0	COG0008@1|root,COG0008@2|Bacteria,1TPJC@1239|Firmicutes,2482P@186801|Clostridia,36E95@31979|Clostridiaceae	186801|Clostridia	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17,6.1.1.24	ko:K01885,ko:K09698	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R03651,R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
HKD2_k127_7977457_8	1094508.Tsac_1094	1.616e-46	175.0	COG1418@1|root,COG1418@2|Bacteria,1VAEC@1239|Firmicutes,251UX@186801|Clostridia	186801|Clostridia	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	ko:K06950	-	-	-	-	ko00000	-	-	-	HD
HKD2_k127_7977457_9	536227.CcarbDRAFT_3531	9.652e-40	166.0	COG1305@1|root,COG1305@2|Bacteria	2|Bacteria	E	Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	TIG,Transglut_core
HKD2_k127_7977457_10	714961.BFZC1_18465	3.404e-21	108.0	COG3103@1|root,COG4193@1|root,COG4193@2|Bacteria,COG4991@2|Bacteria,1V1F9@1239|Firmicutes,4HBQV@91061|Bacilli,3IYSS@400634|Lysinibacillus	91061|Bacilli	GT	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase	-	-	3.2.1.96	ko:K01227	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000	-	-	-	CHAP,Glucosaminidase,SH3_3,SLH
HKD2_k127_7977492_0	243275.TDE_0047	1.074e-147	477.0	COG1228@1|root,COG1228@2|Bacteria,2J5E4@203691|Spirochaetes	203691|Spirochaetes	F	Imidazolone-5-propionate hydrolase	hutI	-	3.5.2.7	ko:K01468	ko00340,ko01100,map00340,map01100	M00045	R02288	RC00683	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
HKD2_k127_7977492_6	1347392.CCEZ01000010_gene2405	5.378e-57	205.0	COG3404@1|root,COG3404@2|Bacteria,1V1X8@1239|Firmicutes,24JZM@186801|Clostridia,36JRA@31979|Clostridiaceae	186801|Clostridia	E	cyclohydrolase	fchA	-	-	-	-	-	-	-	-	-	-	-	FTCD_C
HKD2_k127_7977492_9	858215.Thexy_0284	1.049e-11	68.0	COG4224@1|root,COG4224@2|Bacteria,1UEJA@1239|Firmicutes,25JH3@186801|Clostridia,42H7T@68295|Thermoanaerobacterales	186801|Clostridia	S	UPF0291 protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF896
HKD2_k127_7977492_7	1304284.L21TH_0274	1.654e-47	175.0	COG0835@1|root,COG0835@2|Bacteria,1V4HH@1239|Firmicutes,24JV4@186801|Clostridia,36ITK@31979|Clostridiaceae	186801|Clostridia	NT	Chemotaxis protein cheW	cheW	-	-	ko:K03408	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheW
HKD2_k127_7977492_2	203119.Cthe_1268	1.272e-113	377.0	COG4585@1|root,COG4585@2|Bacteria,1TQI3@1239|Firmicutes,249R9@186801|Clostridia,3WN3W@541000|Ruminococcaceae	186801|Clostridia	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	degS	-	2.7.13.3	ko:K07777	ko02020,map02020	M00478	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	DegS,HATPase_c,HisKA_3
HKD2_k127_7977492_4	1408422.JHYF01000002_gene2301	3.16e-81	276.0	COG2197@1|root,COG2197@2|Bacteria,1TRXG@1239|Firmicutes,24FZX@186801|Clostridia,36H48@31979|Clostridiaceae	186801|Clostridia	K	response regulator, receiver	degU	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HKD2_k127_7977492_5	649747.HMPREF0083_00841	1.261e-77	281.0	COG0457@1|root,COG0457@2|Bacteria,1UBH2@1239|Firmicutes,4HB47@91061|Bacilli,26R7D@186822|Paenibacillaceae	91061|Bacilli	S	fOG TPR repeat	yvcD	-	-	-	-	-	-	-	-	-	-	-	HTH_psq,TPR_16,TPR_19,TPR_2,TPR_8
HKD2_k127_7977492_3	1031288.AXAA01000009_gene681	2.51e-84	283.0	COG1853@1|root,COG1853@2|Bacteria,1V1EA@1239|Firmicutes,24FWS@186801|Clostridia,36FKV@31979|Clostridiaceae	186801|Clostridia	S	flavin reductase	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
HKD2_k127_7977492_11	411470.RUMGNA_01176	0.000369	46.0	2DSHC@1|root,33G4Q@2|Bacteria,1VMRV@1239|Firmicutes,25AFM@186801|Clostridia,3Y0T4@572511|Blautia	186801|Clostridia	S	Psort location Extracellular, score 8.82	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7977492_1	857293.CAAU_0041	7.897e-134	439.0	COG1253@1|root,COG1253@2|Bacteria,1TPN0@1239|Firmicutes,2489N@186801|Clostridia,36F3D@31979|Clostridiaceae	186801|Clostridia	S	CBS domain	-	-	-	ko:K03699	-	-	-	-	ko00000,ko02042	-	-	-	CBS,CorC_HlyC,DUF21
HKD2_k127_7977492_10	1120746.CCNL01000014_gene2079	7.884e-05	45.0	COG1961@1|root,COG1961@2|Bacteria,2NQ37@2323|unclassified Bacteria	2|Bacteria	L	Recombinase	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
HKD2_k127_7977492_8	1304284.L21TH_2160	2.854e-39	161.0	COG1376@1|root,COG1376@2|Bacteria,1TQAB@1239|Firmicutes,25BS1@186801|Clostridia	186801|Clostridia	S	L,D-transpeptidase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	YkuD
HKD2_k127_7986201_2	580340.Tlie_0508	1.069e-46	171.0	COG0450@1|root,COG0450@2|Bacteria,3TB27@508458|Synergistetes	508458|Synergistetes	O	Alkyl hydroperoxide reductase	-	-	1.11.1.15	ko:K03386	ko04214,map04214	-	-	-	ko00000,ko00001,ko01000,ko04147	-	-	-	1-cysPrx_C,AhpC-TSA
HKD2_k127_7986201_1	868131.MSWAN_2169	4.056e-49	184.0	arCOG02575@1|root,arCOG02575@2157|Archaea,2XZ2N@28890|Euryarchaeota,23P4G@183925|Methanobacteria	183925|Methanobacteria	S	Flavodoxin-like fold	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
HKD2_k127_7986201_3	86416.Clopa_4696	2.463e-33	137.0	COG1309@1|root,COG1309@2|Bacteria,1VINQ@1239|Firmicutes	1239|Firmicutes	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
HKD2_k127_7986201_0	509191.AEDB02000073_gene1980	2.332e-275	861.0	COG1331@1|root,COG1331@2|Bacteria,1TPRD@1239|Firmicutes,248PD@186801|Clostridia,3WHE8@541000|Ruminococcaceae	186801|Clostridia	O	Protein of unknown function, DUF255	-	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	GlcNAc_2-epim,Thioredox_DsbH
HKD2_k127_8015822_5	293826.Amet_3023	4.317e-16	79.0	COG1308@1|root,COG1308@2|Bacteria,1V7I9@1239|Firmicutes,24M6Q@186801|Clostridia,36JCP@31979|Clostridiaceae	186801|Clostridia	K	UBA TS-N domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4342
HKD2_k127_8015822_1	350688.Clos_1253	7.147e-57	207.0	COG1381@1|root,COG1381@2|Bacteria,1UZ19@1239|Firmicutes,249TI@186801|Clostridia,36FFV@31979|Clostridiaceae	186801|Clostridia	L	Involved in DNA repair and RecF pathway recombination	recO	-	-	ko:K03584	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecO_C,RecO_N
HKD2_k127_8015822_0	97138.C820_02365	5.441e-106	351.0	COG1159@1|root,COG1159@2|Bacteria,1TP3R@1239|Firmicutes,24876@186801|Clostridia,36DFX@31979|Clostridiaceae	186801|Clostridia	S	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism	era	-	-	ko:K03595	-	-	-	-	ko00000,ko03009,ko03029	-	-	-	KH_2,MMR_HSR1
HKD2_k127_8015822_2	411463.EUBVEN_01248	5.605e-41	154.0	COG0295@1|root,COG0295@2|Bacteria,1V6IP@1239|Firmicutes,24JEM@186801|Clostridia,25WWH@186806|Eubacteriaceae	186801|Clostridia	F	This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis	cdd	-	3.5.4.5	ko:K01489	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01878,R02485,R08221	RC00074,RC00514	ko00000,ko00001,ko01000	-	-	-	dCMP_cyt_deam_1,dCMP_cyt_deam_2
HKD2_k127_8015822_3	1128398.Curi_c18120	1.134e-31	130.0	COG1470@1|root,COG1470@2|Bacteria,1TRGE@1239|Firmicutes,24EHG@186801|Clostridia,267X6@186813|unclassified Clostridiales	186801|Clostridia	S	Protein of unknown function (DUF3048) C-terminal domain	yerB	-	-	-	-	-	-	-	-	-	-	-	DUF3048,DUF3048_C
HKD2_k127_8015822_4	635013.TherJR_2420	1.134e-31	130.0	COG1470@1|root,COG1470@2|Bacteria,1TRGE@1239|Firmicutes,24EHG@186801|Clostridia	186801|Clostridia	D	Protein of unknown function (DUF3048) C-terminal domain	yerB	-	-	-	-	-	-	-	-	-	-	-	DUF3048,DUF3048_C
HKD2_k127_8033142_3	857293.CAAU_0151	9.222e-133	428.0	COG1653@1|root,COG1653@2|Bacteria,1TRPJ@1239|Firmicutes,24872@186801|Clostridia,36F95@31979|Clostridiaceae	186801|Clostridia	G	solute-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_8
HKD2_k127_8033142_1	857293.CAAU_0150	4.51e-140	451.0	COG1175@1|root,COG1175@2|Bacteria,1TS63@1239|Firmicutes,2489M@186801|Clostridia,36H73@31979|Clostridiaceae	186801|Clostridia	G	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
HKD2_k127_8033142_2	857293.CAAU_0149	3.451e-134	432.0	COG0395@1|root,COG0395@2|Bacteria,1TS0R@1239|Firmicutes,248UX@186801|Clostridia,36FNN@31979|Clostridiaceae	186801|Clostridia	G	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02026,ko:K10242	ko02010,map02010	M00206,M00207	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.23	-	-	BPD_transp_1
HKD2_k127_8033142_0	857293.CAAU_0147	9.892e-148	474.0	COG1609@1|root,COG1609@2|Bacteria,1TRFH@1239|Firmicutes,24A4M@186801|Clostridia,36DDD@31979|Clostridiaceae	186801|Clostridia	K	helix_turn _helix lactose operon repressor	-	-	-	ko:K02529,ko:K03604	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
HKD2_k127_8033142_4	1321778.HMPREF1982_01068	4.875e-38	142.0	COG2723@1|root,COG2723@2|Bacteria,1TP19@1239|Firmicutes,2485V@186801|Clostridia	186801|Clostridia	G	Belongs to the glycosyl hydrolase 1 family	-	-	3.2.1.21	ko:K05350	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_1,PMI_typeI
HKD2_k127_8036885_2	857293.CAAU_1543	2.072e-13	74.0	COG1574@1|root,COG1574@2|Bacteria,1TQ6G@1239|Firmicutes,24A5F@186801|Clostridia,36DJ1@31979|Clostridiaceae	186801|Clostridia	S	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
HKD2_k127_8036885_0	1128398.Curi_c06470	6.905e-113	369.0	COG1116@1|root,COG1116@2|Bacteria,1TRM6@1239|Firmicutes,248CG@186801|Clostridia,26AP6@186813|unclassified Clostridiales	186801|Clostridia	P	ATPases associated with a variety of cellular activities	ssuB_2	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
HKD2_k127_8036885_1	1449126.JQKL01000029_gene2547	3.707e-95	319.0	COG0600@1|root,COG0600@2|Bacteria,1TR6A@1239|Firmicutes,247VM@186801|Clostridia,26AD5@186813|unclassified Clostridiales	186801|Clostridia	P	Binding-protein-dependent transport system inner membrane component	ssuC_2	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
HKD2_k127_8044170_2	293826.Amet_3538	3.942e-203	644.0	COG1109@1|root,COG1208@1|root,COG1109@2|Bacteria,COG1208@2|Bacteria,1VDBC@1239|Firmicutes,24AGU@186801|Clostridia,36UK6@31979|Clostridiaceae	186801|Clostridia	GJM	phosphoglucomutase phosphomannomutase alpha beta alpha domain I	-	-	2.7.7.13,5.4.2.8	ko:K00966,ko:K16881	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114,M00361,M00362	R00885,R01818	RC00002,RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase,PGM_PMM_I
HKD2_k127_8044170_0	720554.Clocl_2838	0.0	1105.0	COG0013@1|root,COG0013@2|Bacteria,1TPK6@1239|Firmicutes,248M3@186801|Clostridia,3WGEX@541000|Ruminococcaceae	186801|Clostridia	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
HKD2_k127_8044170_8	1304284.L21TH_1999	2.207e-78	274.0	COG0628@1|root,COG0628@2|Bacteria,1TQ84@1239|Firmicutes,248FS@186801|Clostridia,36EAC@31979|Clostridiaceae	186801|Clostridia	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
HKD2_k127_8044170_21	635013.TherJR_1909	1.595e-11	72.0	COG3881@1|root,COG3881@2|Bacteria,1VEG9@1239|Firmicutes,24RA7@186801|Clostridia	186801|Clostridia	S	PFAM PRC-barrel domain	-	-	-	-	-	-	-	-	-	-	-	-	PRC
HKD2_k127_8044170_19	720554.Clocl_2117	2.328e-13	72.0	2EM44@1|root,339E4@2|Bacteria,1VH49@1239|Firmicutes,24TJS@186801|Clostridia,3WQ74@541000|Ruminococcaceae	186801|Clostridia	S	Rubrerythrin	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
HKD2_k127_8044170_5	720554.Clocl_1836	2.998e-161	514.0	COG0482@1|root,COG0482@2|Bacteria,1TPIZ@1239|Firmicutes,247YV@186801|Clostridia,3WGZU@541000|Ruminococcaceae	186801|Clostridia	J	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34	mnmA	-	2.8.1.13	ko:K00566	ko04122,map04122	-	R08700	RC02313,RC02315	ko00000,ko00001,ko01000,ko03016	-	-	-	tRNA_Me_trans
HKD2_k127_8044170_14	1160721.RBI_I01200	4.226e-58	204.0	COG0822@1|root,COG0822@2|Bacteria,1V3H9@1239|Firmicutes,24HDD@186801|Clostridia,3WITG@541000|Ruminococcaceae	186801|Clostridia	C	Fe-S iron-sulfur cluster assembly protein, NifU family	nifU	-	-	ko:K04488	-	-	-	-	ko00000	-	-	-	NifU_N
HKD2_k127_8044170_3	941824.TCEL_00309	1.17e-182	578.0	COG1104@1|root,COG1104@2|Bacteria,1TP21@1239|Firmicutes,24888@186801|Clostridia,36DXY@31979|Clostridiaceae	186801|Clostridia	E	Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins	iscS	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
HKD2_k127_8044170_16	350688.Clos_1671	3.518e-52	188.0	COG1959@1|root,COG1959@2|Bacteria,1V3QB@1239|Firmicutes,24JIV@186801|Clostridia,36J5P@31979|Clostridiaceae	186801|Clostridia	K	Transcriptional regulator	iscR	-	-	-	-	-	-	-	-	-	-	-	Rrf2
HKD2_k127_8044170_13	720555.BATR1942_01240	8.282e-70	246.0	COG1442@1|root,COG1442@2|Bacteria,1VS6N@1239|Firmicutes,4HUAY@91061|Bacilli,1ZRVS@1386|Bacillus	91061|Bacilli	M	Nucleotide-diphospho-sugar transferase	yfnF	-	-	-	-	-	-	-	-	-	-	-	Nucleotid_trans
HKD2_k127_8044170_15	1117108.PAALTS15_14321	5.654e-53	199.0	COG2334@1|root,COG2334@2|Bacteria,1TYJQ@1239|Firmicutes,4I162@91061|Bacilli,26X60@186822|Paenibacillaceae	91061|Bacilli	S	Phosphotransferase enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	APH
HKD2_k127_8044170_18	1395513.P343_09525	1.03e-38	151.0	COG0515@1|root,COG0515@2|Bacteria,1VBSJ@1239|Firmicutes,4HKRP@91061|Bacilli	91061|Bacilli	KLT	COG0515 Serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	RIO1
HKD2_k127_8044170_17	1403313.AXBR01000005_gene1805	1.761e-42	163.0	COG0515@1|root,COG0515@2|Bacteria,1VBSJ@1239|Firmicutes,4HKRP@91061|Bacilli,1ZHE2@1386|Bacillus	91061|Bacilli	KLT	COG0515 Serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	RIO1
HKD2_k127_8044170_20	326423.RBAM_007560	5.028e-12	68.0	COG1442@1|root,COG1442@2|Bacteria,1UZ8Q@1239|Firmicutes,4HURC@91061|Bacilli,1ZF68@1386|Bacillus	91061|Bacilli	M	Nucleotide-diphospho-sugar transferase	yfnD	-	-	-	-	-	-	-	-	-	-	-	Nucleotid_trans
HKD2_k127_8044170_10	1121091.AUMP01000001_gene316	7.175e-74	255.0	COG1442@1|root,COG1442@2|Bacteria,1UZ8Q@1239|Firmicutes,4HURC@91061|Bacilli	91061|Bacilli	M	Nucleotide-diphospho-sugar transferase	yfnD	-	-	-	-	-	-	-	-	-	-	-	Nucleotid_trans
HKD2_k127_8044170_12	1117379.BABA_12785	7.242e-71	250.0	COG1442@1|root,COG1442@2|Bacteria,1VDR9@1239|Firmicutes,4IRMX@91061|Bacilli,1ZESE@1386|Bacillus	91061|Bacilli	M	glycosyl transferase family 8	-	-	-	-	-	-	-	-	-	-	-	-	Nucleotid_trans
HKD2_k127_8044170_6	326423.RBAM_007530	5.821e-159	506.0	COG0451@1|root,COG0451@2|Bacteria,1VP6I@1239|Firmicutes,4ISWU@91061|Bacilli,1ZFBK@1386|Bacillus	91061|Bacilli	M	dehydratase	yfnG	-	4.2.1.45,4.2.1.46	ko:K01709,ko:K01710	ko00520,ko00521,ko00523,ko00525,ko01055,ko01130,map00520,map00521,map00523,map00525,map01055,map01130	M00793	R02426,R06513	RC00402	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
HKD2_k127_8044170_7	1121091.AUMP01000001_gene312	4.012e-102	338.0	COG1208@1|root,COG1208@2|Bacteria,1TT1F@1239|Firmicutes,4HUVJ@91061|Bacilli	91061|Bacilli	JM	Nucleotidyl transferase	yfnH	-	2.7.7.33	ko:K00978	ko00500,ko00520,ko01100,map00500,map00520,map01100	-	R00956	RC00002	ko00000,ko00001,ko01000	-	-	-	NTP_transferase
HKD2_k127_8044170_11	1121091.AUMP01000001_gene315	1.194e-71	256.0	COG1216@1|root,COG1216@2|Bacteria,1VDP9@1239|Firmicutes,4IPY5@91061|Bacilli	91061|Bacilli	S	Glycosyl transferase family 2	yfnE	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HKD2_k127_8044170_1	941824.TCEL_02324	3.624e-288	890.0	COG0488@1|root,COG0488@2|Bacteria,1TPAX@1239|Firmicutes,247U6@186801|Clostridia,36ER9@31979|Clostridiaceae	186801|Clostridia	S	ABC transporter	yfmM	-	-	ko:K06158	-	-	-	-	ko00000,ko03012	-	-	-	ABC_tran,ABC_tran_Xtn
HKD2_k127_8044170_9	1304284.L21TH_2010	1.418e-77	267.0	COG1215@1|root,COG1215@2|Bacteria,1V7YV@1239|Firmicutes,24IIA@186801|Clostridia,36JCY@31979|Clostridiaceae	186801|Clostridia	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HKD2_k127_8044170_22	509635.N824_19860	1.985e-06	59.0	COG1940@1|root,COG1940@2|Bacteria,4NFNR@976|Bacteroidetes,1IPGV@117747|Sphingobacteriia	976|Bacteroidetes	GK	ROK family	ppgK	-	2.7.1.2,2.7.1.63	ko:K00845,ko:K00886	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786,R02187,R02189	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
HKD2_k127_8044170_23	203119.Cthe_1088	5.759e-06	57.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554,DUF1863,TIR_2
HKD2_k127_8044170_4	1304284.L21TH_0539	1.549e-178	568.0	COG2256@1|root,COG2256@2|Bacteria,1TPVV@1239|Firmicutes,247X2@186801|Clostridia,36EXD@31979|Clostridiaceae	186801|Clostridia	L	AAA ATPase	rarA	-	-	ko:K07478	-	-	-	-	ko00000	-	-	-	AAA,AAA_assoc_2,MgsA_C,RuvB_N
HKD2_k127_8056032_1	203119.Cthe_2040	0.0	1223.0	COG3857@1|root,COG3857@2|Bacteria,1TQJW@1239|Firmicutes,2487T@186801|Clostridia,3WG8U@541000|Ruminococcaceae	186801|Clostridia	L	ATP-dependent helicase deoxyribonuclease subunit B	addB	-	3.6.4.12	ko:K16899	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	Exonuc_V_gamma,PDDEXK_1,UvrD_C
HKD2_k127_8056032_0	720554.Clocl_3382	0.0	1310.0	COG1074@1|root,COG1074@2|Bacteria,1TQ35@1239|Firmicutes,248ZF@186801|Clostridia,3WGE1@541000|Ruminococcaceae	186801|Clostridia	L	ATP-dependent helicase nuclease subunit A	addA	-	3.6.4.12	ko:K16898	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
HKD2_k127_8056032_6	1408473.JHXO01000008_gene2695	8.093e-19	90.0	arCOG12964@1|root,2Z7HP@2|Bacteria,4P10P@976|Bacteroidetes	976|Bacteroidetes	S	Tocopherol cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Tocopherol_cycl
HKD2_k127_8056032_3	203119.Cthe_2521	5.086e-71	247.0	COG1191@1|root,COG1191@2|Bacteria,1V5E6@1239|Firmicutes,24I8Q@186801|Clostridia,3WJU1@541000|Ruminococcaceae	186801|Clostridia	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	sigI	-	-	ko:K03093	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2
HKD2_k127_8056032_5	203119.Cthe_2522	1.908e-33	142.0	2E3R1@1|root,32YNU@2|Bacteria,1VEND@1239|Firmicutes,24RRZ@186801|Clostridia,3WKJ8@541000|Ruminococcaceae	186801|Clostridia	S	Anti-sigma factor N-terminus	-	-	-	-	-	-	-	-	-	-	-	-	RsgI_N
HKD2_k127_8056032_2	1120973.AQXL01000134_gene1622	1.785e-120	400.0	COG0420@1|root,COG0420@2|Bacteria,1TQY6@1239|Firmicutes,4HAKB@91061|Bacilli	91061|Bacilli	L	SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'- 5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity	sbcD	-	-	ko:K03547	-	-	-	-	ko00000,ko03400	-	-	-	Metallophos,Metallophos_2,SbcD_C
HKD2_k127_8056032_4	1123226.KB899278_gene750	6.58e-61	220.0	COG0419@1|root,COG0419@2|Bacteria,1TPCS@1239|Firmicutes,4H9Q3@91061|Bacilli,26QV1@186822|Paenibacillaceae	91061|Bacilli	L	ATPase involved in DNA repair	sbcC	-	-	ko:K03546	-	-	-	-	ko00000,ko03400	-	-	-	AAA_23,AAA_29,SbcCD_C
HKD2_k127_8070377_2	293826.Amet_3159	4.921e-196	628.0	COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247Q0@186801|Clostridia,36DEY@31979|Clostridiaceae	186801|Clostridia	V	ABC transporter transmembrane region	-	-	-	ko:K18889	ko02010,map02010	M00707	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.106.13,3.A.1.106.5	-	-	ABC_membrane,ABC_tran
HKD2_k127_8070377_1	293826.Amet_3160	8.681e-252	794.0	COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247Q0@186801|Clostridia,36E82@31979|Clostridiaceae	186801|Clostridia	V	ABC transporter transmembrane region	-	-	-	ko:K18890	ko02010,map02010	M00707	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.106.13,3.A.1.106.5	-	-	ABC_membrane,ABC_tran
HKD2_k127_8070377_4	869213.JCM21142_41645	1.3e-51	188.0	COG0693@1|root,COG0693@2|Bacteria,4NKD1@976|Bacteroidetes,47VNU@768503|Cytophagia	976|Bacteroidetes	S	DJ-1/PfpI family	-	-	-	-	-	-	-	-	-	-	-	-	DJ-1_PfpI
HKD2_k127_8070377_3	696369.KI912183_gene127	2.312e-60	212.0	COG0328@1|root,COG0328@2|Bacteria,1V4A0@1239|Firmicutes,24FSS@186801|Clostridia,26219@186807|Peptococcaceae	186801|Clostridia	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhA	-	3.1.26.4	ko:K03469	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_H
HKD2_k127_8070377_0	580331.Thit_0030	1.104e-262	840.0	COG1615@1|root,COG1615@2|Bacteria,1TQHM@1239|Firmicutes,248PM@186801|Clostridia,42FMF@68295|Thermoanaerobacterales	186801|Clostridia	S	PFAM Uncharacterised protein family (UPF0182)	-	-	-	ko:K09118	-	-	-	-	ko00000	-	-	-	UPF0182
HKD2_k127_8070377_5	1540257.JQMW01000011_gene2307	1.436e-16	82.0	COG2199@1|root,COG2203@1|root,COG3899@1|root,COG2203@2|Bacteria,COG3706@2|Bacteria,COG3899@2|Bacteria,1V9Y7@1239|Firmicutes,24A8B@186801|Clostridia,36E8P@31979|Clostridiaceae	186801|Clostridia	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GGDEF,Pkinase,TPR_12,TPR_8
HKD2_k127_8082641_6	484770.UFO1_0940	4.026e-52	188.0	COG2213@1|root,COG4668@1|root,COG2213@2|Bacteria,COG4668@2|Bacteria,1TPE3@1239|Firmicutes,4H313@909932|Negativicutes	909932|Negativicutes	G	PTS system mannitol-specific	mtlA	-	2.7.1.197	ko:K02798,ko:K02799,ko:K02800	ko00051,ko02060,map00051,map02060	M00274	R02704	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.2.1.12,4.A.2.1.2,4.A.2.1.24,4.A.2.1.5	-	-	PTS_EIIA_2,PTS_EIIC,PTS_IIB
HKD2_k127_8082641_4	1195236.CTER_1037	3.142e-86	295.0	COG1105@1|root,COG1105@2|Bacteria,1TQ36@1239|Firmicutes,249RK@186801|Clostridia,3WH8H@541000|Ruminococcaceae	186801|Clostridia	H	Belongs to the carbohydrate kinase PfkB family. LacC subfamily	pfkB	-	2.7.1.56	ko:K00882	ko00051,map00051	-	R02071	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
HKD2_k127_8082641_0	293826.Amet_4267	2.203e-202	636.0	COG1063@1|root,COG1063@2|Bacteria,1TQ60@1239|Firmicutes,248JR@186801|Clostridia,36H91@31979|Clostridiaceae	186801|Clostridia	E	PFAM Alcohol dehydrogenase	-	-	-	ko:K19956	ko00051,map00051	-	R03234	RC00089	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
HKD2_k127_8082641_9	656519.Halsa_1174	1.843e-20	93.0	COG1925@1|root,COG1925@2|Bacteria,1VA0R@1239|Firmicutes,24QIP@186801|Clostridia	186801|Clostridia	G	phosphocarrier, HPr family	-	-	-	ko:K11189	-	-	-	-	ko00000,ko02000	4.A.2.1	-	-	PTS-HPr
HKD2_k127_8082641_1	1304284.L21TH_2295	3.155e-176	569.0	COG1080@1|root,COG1080@2|Bacteria,1TPK8@1239|Firmicutes,248QP@186801|Clostridia,36DCW@31979|Clostridiaceae	186801|Clostridia	G	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)	ptsP	-	2.7.3.9,2.7.9.2	ko:K01007,ko:K08483	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,ko02060,map00620,map00680,map00720,map01100,map01120,map01200,map02060	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko02000	8.A.7	-	-	PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C
HKD2_k127_8082641_3	645991.Sgly_2008	1.667e-90	304.0	28NMK@1|root,2ZBN3@2|Bacteria,1TT4K@1239|Firmicutes,24EKK@186801|Clostridia,261U5@186807|Peptococcaceae	186801|Clostridia	U	Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane	amj	-	-	-	-	-	-	-	-	-	-	-	Amj
HKD2_k127_8082641_5	861454.HMPREF9099_00005	1.663e-59	211.0	COG3012@1|root,COG3012@2|Bacteria,1V1CC@1239|Firmicutes,24FYC@186801|Clostridia,27MFJ@186928|unclassified Lachnospiraceae	186801|Clostridia	U	SEC-C motif	secA_2	-	-	-	-	-	-	-	-	-	-	-	SEC-C
HKD2_k127_8082641_7	572547.Amico_0050	3.706e-48	178.0	COG0225@1|root,COG0225@2|Bacteria	2|Bacteria	O	peptide-methionine (S)-S-oxide reductase activity	msrA	-	1.8.4.11,1.8.4.12	ko:K07304,ko:K12267	-	-	-	-	ko00000,ko01000	-	-	-	PMSR,SelR
HKD2_k127_8082641_2	935836.JAEL01000059_gene721	3.262e-168	542.0	COG0154@1|root,COG0154@2|Bacteria,1TRFI@1239|Firmicutes,4HBZA@91061|Bacilli,1ZCZT@1386|Bacillus	91061|Bacilli	J	COG0154 Asp-tRNAAsn Glu-tRNAGln amidotransferase A subunit and related amidases	-	-	3.5.1.4	ko:K01426	ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120	-	R02540,R03096,R03180,R03909,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000	-	-	-	Amidase
HKD2_k127_8082641_8	1487921.DP68_06180	9.379e-25	105.0	2ED4Q@1|root,307YN@2|Bacteria,1U2FP@1239|Firmicutes,24NIT@186801|Clostridia,36KVQ@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8093069_1	1499689.CCNN01000007_gene1034	5.991e-64	224.0	COG1544@1|root,COG1544@2|Bacteria,1V1D5@1239|Firmicutes,24HDH@186801|Clostridia,36I5Z@31979|Clostridiaceae	186801|Clostridia	J	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase	hpf	-	-	ko:K05808	-	-	-	-	ko00000,ko03009	-	-	-	Ribosom_S30AE_C,Ribosomal_S30AE
HKD2_k127_8093069_2	1304284.L21TH_2303	7.626e-36	144.0	2C0MY@1|root,2ZC2Z@2|Bacteria,1V9XB@1239|Firmicutes,24PCF@186801|Clostridia,36J6H@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8093069_0	1121289.JHVL01000017_gene731	1.845e-105	356.0	COG2206@1|root,COG2206@2|Bacteria,1UZN2@1239|Firmicutes,25EWN@186801|Clostridia,36USS@31979|Clostridiaceae	186801|Clostridia	T	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF3369,GAF_2,HAMP,HD,HD_5,Reg_prop,Response_reg,Y_Y_Y
HKD2_k127_8093069_3	1304284.L21TH_2301	1.328e-06	51.0	29Y0M@1|root,30JTI@2|Bacteria,1V50V@1239|Firmicutes,24GAX@186801|Clostridia,36K0I@31979|Clostridiaceae	186801|Clostridia	S	Family of unknown function (DUF5317)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5317
HKD2_k127_8116664_9	1280390.CBQR020000094_gene2105	2.786e-33	130.0	COG5566@1|root,COG5566@2|Bacteria,1VEZS@1239|Firmicutes,4HNM8@91061|Bacilli,26Y3N@186822|Paenibacillaceae	91061|Bacilli	S	Mor transcription activator family	-	-	-	-	-	-	-	-	-	-	-	-	Mor
HKD2_k127_8116664_1	35841.BT1A1_0914	3.842e-126	413.0	COG1162@1|root,COG1162@2|Bacteria,1TP8Q@1239|Firmicutes,4H9PJ@91061|Bacilli,1ZCAI@1386|Bacillus	91061|Bacilli	S	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit	rsgA_2	-	3.1.3.100	ko:K06949	ko00730,ko01100,map00730,map01100	-	R00615,R02135	RC00002,RC00017	ko00000,ko00001,ko01000,ko03009	-	-	-	RsgA_GTPase
HKD2_k127_8116664_0	1487921.DP68_12905	5.694e-132	434.0	COG1757@1|root,COG1757@2|Bacteria,1TQ3B@1239|Firmicutes,248WN@186801|Clostridia,36FFK@31979|Clostridiaceae	186801|Clostridia	C	Na H antiporter	-	-	-	ko:K03315	-	-	-	-	ko00000,ko02000	2.A.35	-	-	Na_H_antiporter
HKD2_k127_8116664_6	1410653.JHVC01000001_gene1635	8.654e-73	250.0	COG0490@1|root,COG2188@1|root,COG0490@2|Bacteria,COG2188@2|Bacteria,1UZRI@1239|Firmicutes,2496Y@186801|Clostridia,36E5U@31979|Clostridiaceae	186801|Clostridia	K	hmm pf02080	-	-	-	-	-	-	-	-	-	-	-	-	GntR,TrkA_C
HKD2_k127_8116664_10	1121289.JHVL01000042_gene3085	2.017e-29	129.0	28I50@1|root,2Z88F@2|Bacteria,1V10M@1239|Firmicutes,24I2A@186801|Clostridia,36UAU@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8116664_13	1122917.KB899660_gene1395	3.874e-17	95.0	COG5513@1|root,COG5513@2|Bacteria,1V4PH@1239|Firmicutes,4HG7Y@91061|Bacilli	91061|Bacilli	S	Protein of unknown function (DUF3298)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3298,DUF4163
HKD2_k127_8116664_7	632335.Calkr_1515	3.61e-69	255.0	COG5263@1|root,COG5263@2|Bacteria,1V2GT@1239|Firmicutes,24EI0@186801|Clostridia,42IJP@68295|Thermoanaerobacterales	186801|Clostridia	S	WG containing repeat	-	-	-	-	-	-	-	-	-	-	-	-	Cu_amine_oxidN1,WG_beta_rep
HKD2_k127_8116664_12	1487921.DP68_10685	1.122e-17	92.0	2BAT8@1|root,3248G@2|Bacteria,1UQJS@1239|Firmicutes,24U7H@186801|Clostridia,36SHK@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8116664_14	479436.Vpar_0467	2.478e-09	65.0	COG2885@1|root,COG3637@1|root,COG2885@2|Bacteria,COG3637@2|Bacteria,1UZZN@1239|Firmicutes,4H3VX@909932|Negativicutes	909932|Negativicutes	M	Belongs to the ompA family	-	-	-	ko:K03286	-	-	-	-	ko00000,ko02000	1.B.6	-	-	OMP_b-brl,OmpA
HKD2_k127_8116664_3	1294142.CINTURNW_1739	1.808e-101	350.0	COG0642@1|root,COG0642@2|Bacteria,1UYZX@1239|Firmicutes,25E9T@186801|Clostridia,36US5@31979|Clostridiaceae	186801|Clostridia	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	4HB_MCP_1,GAF_2,HATPase_c,HisKA,Response_reg
HKD2_k127_8116664_5	1410653.JHVC01000006_gene146	1.466e-73	253.0	COG2844@1|root,COG2844@2|Bacteria,1V2GH@1239|Firmicutes,24FRR@186801|Clostridia,36I1R@31979|Clostridiaceae	186801|Clostridia	O	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	HD
HKD2_k127_8116664_8	1078085.HMPREF1210_02763	3.839e-43	168.0	COG1295@1|root,COG1295@2|Bacteria,1U7HM@1239|Firmicutes,4H9MJ@91061|Bacilli,26CYV@186818|Planococcaceae	91061|Bacilli	S	Belongs to the UPF0761 family	-	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Virul_fac_BrkB
HKD2_k127_8116664_11	509191.AEDB02000100_gene4084	6.755e-29	121.0	COG4753@1|root,COG4753@2|Bacteria,1UJJ3@1239|Firmicutes,25F44@186801|Clostridia,3WP7C@541000|Ruminococcaceae	186801|Clostridia	T	cheY-homologous receiver domain	-	-	-	ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	Response_reg
HKD2_k127_8116664_2	865861.AZSU01000005_gene948	2.264e-115	379.0	COG2355@1|root,COG2355@2|Bacteria,1UA7M@1239|Firmicutes,24AE6@186801|Clostridia,36EIQ@31979|Clostridiaceae	186801|Clostridia	E	PFAM Peptidase M19, renal dipeptidase	-	-	3.4.13.19	ko:K01273	-	-	-	-	ko00000,ko00537,ko01000,ko01002,ko04147	-	-	-	Peptidase_M19
HKD2_k127_8116664_4	1405.DJ92_4532	4.364e-101	335.0	2DB8K@1|root,2Z7S1@2|Bacteria,1TRA1@1239|Firmicutes,4HBIE@91061|Bacilli,1ZE40@1386|Bacillus	91061|Bacilli	G	Streptomycin adenylyltransferase	aadK	-	-	ko:K05593	-	-	-	-	ko00000,ko01000,ko01504	-	-	-	Adenyl_transf
HKD2_k127_8117223_4	580327.Tthe_1203	1.361e-32	133.0	COG1308@1|root,COG1308@2|Bacteria,1V7I9@1239|Firmicutes,24M6Q@186801|Clostridia,42GD9@68295|Thermoanaerobacterales	186801|Clostridia	K	Ubiquitin-associated translation elongation factor EF1B, N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	DUF4342
HKD2_k127_8117223_3	941824.TCEL_01972	2.035e-75	260.0	COG0517@1|root,COG0517@2|Bacteria,1TRZD@1239|Firmicutes,24851@186801|Clostridia,36F8X@31979|Clostridiaceae	186801|Clostridia	K	CBS domain	ccpN	-	-	-	-	-	-	-	-	-	-	-	CBS,HTH_11
HKD2_k127_8117223_2	1304284.L21TH_2073	3.019e-76	265.0	COG1806@1|root,COG1806@2|Bacteria,1TPG0@1239|Firmicutes,249ID@186801|Clostridia,36EQ5@31979|Clostridiaceae	186801|Clostridia	S	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation	yqfL	-	2.7.11.33,2.7.4.28	ko:K09773	-	-	-	-	ko00000,ko01000	-	-	-	Kinase-PPPase
HKD2_k127_8117223_0	318464.IO99_00375	0.0	1259.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1TPK8@1239|Firmicutes,247RW@186801|Clostridia,36DMF@31979|Clostridiaceae	186801|Clostridia	G	Belongs to the PEP-utilizing enzyme family	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
HKD2_k127_8117223_1	340099.Teth39_1689	3.38e-88	295.0	COG4166@1|root,COG4166@2|Bacteria,1TNYQ@1239|Firmicutes,25E4B@186801|Clostridia,42FZA@68295|Thermoanaerobacterales	186801|Clostridia	E	PFAM extracellular solute-binding protein, family 5	-	-	-	ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	SBP_bac_5
HKD2_k127_8133557_2	315750.BPUM_1600	6.312e-89	299.0	COG1692@1|root,COG1692@2|Bacteria,1TR9P@1239|Firmicutes,4HAV5@91061|Bacilli,1ZC3D@1386|Bacillus	91061|Bacilli	S	protein conserved in bacteria	ymdB	GO:0003674,GO:0003824,GO:0004112,GO:0004113,GO:0008081,GO:0016787,GO:0016788,GO:0042578	-	ko:K02029,ko:K02030,ko:K09769	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	YmdB
HKD2_k127_8133557_4	1196029.ALIM01000014_gene3358	2.443e-40	150.0	COG2359@1|root,COG2359@2|Bacteria,1V6G8@1239|Firmicutes,4HIQV@91061|Bacilli,1ZH05@1386|Bacillus	91061|Bacilli	S	Stage V sporulation protein S	spoVS	-	-	ko:K06416	-	-	-	-	ko00000	-	-	-	SpoVS
HKD2_k127_8133557_3	273068.TTE1369	4.307e-85	289.0	COG0613@1|root,COG0613@2|Bacteria,1TPI5@1239|Firmicutes,248H2@186801|Clostridia,42GGH@68295|Thermoanaerobacterales	186801|Clostridia	S	SMART phosphoesterase PHP domain protein	trpH	-	3.1.3.97	ko:K07053	-	-	R00188,R11188	RC00078	ko00000,ko01000	-	-	-	PHP
HKD2_k127_8133557_1	555088.DealDRAFT_1728	1.263e-149	483.0	COG0436@1|root,COG0436@2|Bacteria,1TP0J@1239|Firmicutes,247NQ@186801|Clostridia,42JTD@68298|Syntrophomonadaceae	186801|Clostridia	H	PFAM Aminotransferase class I and II	aspB	-	2.6.1.1	ko:K00812,ko:K10907	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	iHN637.CLJU_RS06550	Aminotran_1_2
HKD2_k127_8133557_0	641107.CDLVIII_1825	4.215e-200	631.0	COG0015@1|root,COG0015@2|Bacteria,1TPMM@1239|Firmicutes,2485N@186801|Clostridia,36DRK@31979|Clostridiaceae	186801|Clostridia	F	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily	purB	-	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	-	ADSL_C,Lyase_1
HKD2_k127_8146522_0	1286171.EAL2_c15950	8.248e-151	488.0	COG3681@1|root,COG3681@2|Bacteria,1TQF5@1239|Firmicutes,2488Q@186801|Clostridia,25YXX@186806|Eubacteriaceae	186801|Clostridia	S	Serine dehydratase alpha chain	-	-	-	-	-	-	-	-	-	-	-	-	SDH_alpha
HKD2_k127_8146522_3	1410653.JHVC01000001_gene1539	6.825e-26	111.0	COG1633@1|root,COG1633@2|Bacteria,1VJB9@1239|Firmicutes,24SA5@186801|Clostridia,36MB8@31979|Clostridiaceae	186801|Clostridia	S	Domain of unknown function (DUF2383)	-	-	1.16.3.1	ko:K03594	ko00860,map00860	-	R00078	RC02758	ko00000,ko00001,ko01000	-	-	-	DUF2383
HKD2_k127_8146522_1	941824.TCEL_00664	9.969e-132	434.0	COG1757@1|root,COG1757@2|Bacteria,1TQ3B@1239|Firmicutes,248WN@186801|Clostridia,36FFK@31979|Clostridiaceae	186801|Clostridia	C	Na H antiporter	nhaC	-	-	ko:K03315	-	-	-	-	ko00000,ko02000	2.A.35	-	-	Na_H_antiporter
HKD2_k127_8146522_2	660470.Theba_2442	8.514e-98	327.0	COG0697@1|root,COG0697@2|Bacteria	2|Bacteria	EG	spore germination	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HKD2_k127_8146522_4	1408422.JHYF01000006_gene1140	6.944e-25	106.0	COG0642@1|root,COG3437@1|root,COG2205@2|Bacteria,COG3437@2|Bacteria,1TQMV@1239|Firmicutes,247SE@186801|Clostridia,36HVH@31979|Clostridiaceae	186801|Clostridia	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	5TM-5TMR_LYT,HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg
HKD2_k127_8147518_6	290402.Cbei_2899	7.674e-08	53.0	COG2050@1|root,COG2050@2|Bacteria,1VG2V@1239|Firmicutes,24T83@186801|Clostridia	186801|Clostridia	Q	PFAM thioesterase superfamily protein	-	-	-	ko:K02614	ko00360,map00360	-	R09840	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	4HBT
HKD2_k127_8147518_1	573061.Clocel_4320	1.002e-88	297.0	COG2364@1|root,COG2364@2|Bacteria,1UXHA@1239|Firmicutes,24AJQ@186801|Clostridia,36KHN@31979|Clostridiaceae	186801|Clostridia	F	Psort location CytoplasmicMembrane, score	-	-	-	ko:K07149	-	-	-	-	ko00000	-	-	-	Cytidylate_kin2
HKD2_k127_8147518_2	428125.CLOLEP_00061	4.442e-81	284.0	COG0628@1|root,COG0628@2|Bacteria,1TQ84@1239|Firmicutes,248FS@186801|Clostridia,3WGFR@541000|Ruminococcaceae	186801|Clostridia	S	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
HKD2_k127_8147518_0	1291050.JAGE01000001_gene1123	2.811e-179	566.0	COG0798@1|root,COG0798@2|Bacteria,1TRMD@1239|Firmicutes,24958@186801|Clostridia,3WIBW@541000|Ruminococcaceae	186801|Clostridia	P	TIGRFAM arsenical-resistance protein	arsB	-	-	ko:K03325	-	-	-	-	ko00000,ko02000	2.A.59	-	-	SBF
HKD2_k127_8147518_3	1321778.HMPREF1982_00630	1.69e-77	261.0	COG0394@1|root,COG0394@2|Bacteria,1V3JW@1239|Firmicutes,24HBX@186801|Clostridia,26BHM@186813|unclassified Clostridiales	186801|Clostridia	T	Low molecular weight phosphatase family	arsC	-	1.20.4.1	ko:K03741	-	-	-	-	ko00000,ko01000	-	-	-	LMWPc
HKD2_k127_8147518_4	1487921.DP68_05765	5.225e-57	200.0	COG0640@1|root,COG0640@2|Bacteria,1V9KK@1239|Firmicutes,24NXW@186801|Clostridia,36JM8@31979|Clostridiaceae	186801|Clostridia	K	regulatory protein, arsR	-	-	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	HTH_5
HKD2_k127_8175450_1	349161.Dred_1836	3.968e-85	286.0	COG0715@1|root,COG0715@2|Bacteria,1TQN5@1239|Firmicutes,248IG@186801|Clostridia,260EA@186807|Peptococcaceae	186801|Clostridia	P	ABC-type nitrate sulfonate bicarbonate transport system, periplasmic component	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
HKD2_k127_8175450_2	580327.Tthe_1033	4.216e-43	164.0	COG0558@1|root,COG0558@2|Bacteria,1V35A@1239|Firmicutes,24IIY@186801|Clostridia,42G5I@68295|Thermoanaerobacterales	186801|Clostridia	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pgsA2	-	2.7.8.41,2.7.8.5	ko:K00995,ko:K08744	ko00564,ko01100,map00564,map01100	-	R01801,R02030	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
HKD2_k127_8175450_0	203119.Cthe_0324	5.4e-323	994.0	COG0525@1|root,COG0525@2|Bacteria,1TPN4@1239|Firmicutes,248VC@186801|Clostridia,3WHFT@541000|Ruminococcaceae	186801|Clostridia	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
HKD2_k127_8181042_2	1128398.Curi_c23820	4.666e-49	187.0	COG0760@1|root,COG0760@2|Bacteria,1TX3R@1239|Firmicutes,24C7H@186801|Clostridia,269ER@186813|unclassified Clostridiales	186801|Clostridia	O	SurA N-terminal domain	prsA	-	5.2.1.8	ko:K03769,ko:K07533	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_2,Rotamase_3,SurA_N_3
HKD2_k127_8181042_0	1449126.JQKL01000009_gene316	2.112e-78	265.0	COG2002@1|root,COG2002@2|Bacteria,1V02A@1239|Firmicutes,248XR@186801|Clostridia,267NR@186813|unclassified Clostridiales	186801|Clostridia	K	SpoVT / AbrB like domain	spoVT	-	-	ko:K04769	-	-	-	-	ko00000,ko03000	-	-	-	MazE_antitoxin,SpoVT_C
HKD2_k127_8181042_1	743719.PaelaDRAFT_5297	3.337e-66	231.0	COG0586@1|root,COG0586@2|Bacteria,1TS2R@1239|Firmicutes,4HA51@91061|Bacilli,26T88@186822|Paenibacillaceae	91061|Bacilli	S	Alkaline phosphatase	apl	-	3.1.3.1	ko:K01077	ko00730,ko00790,ko01100,ko02020,map00730,map00790,map01100,map02020	M00126	R02135,R04620	RC00017	ko00000,ko00001,ko00002,ko00537,ko01000,ko04147	-	-	-	SNARE_assoc
HKD2_k127_8201986_1	645991.Sgly_2397	5.702e-136	443.0	COG1807@1|root,COG1807@2|Bacteria,1V0V2@1239|Firmicutes,24BJF@186801|Clostridia,263AS@186807|Peptococcaceae	186801|Clostridia	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HKD2_k127_8201986_8	37659.JNLN01000001_gene1133	4.873e-29	119.0	COG2510@1|root,COG2510@2|Bacteria,1VFXX@1239|Firmicutes,24NK9@186801|Clostridia,36KRQ@31979|Clostridiaceae	186801|Clostridia	S	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HKD2_k127_8201986_9	1321778.HMPREF1982_01306	9.378e-22	100.0	2DQA6@1|root,335JW@2|Bacteria,1VGTM@1239|Firmicutes,24SG6@186801|Clostridia	186801|Clostridia	S	Uncharacterized conserved protein (DUF2304)	-	-	-	ko:K09153	-	-	-	-	ko00000	-	-	-	DUF2304
HKD2_k127_8201986_3	1280692.AUJL01000002_gene2621	4.044e-82	280.0	COG0463@1|root,COG0463@2|Bacteria,1UJPS@1239|Firmicutes,25F7Y@186801|Clostridia,36VAA@31979|Clostridiaceae	186801|Clostridia	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HKD2_k127_8201986_10	431943.CKL_2284	5.69e-18	85.0	2BX75@1|root,32YCI@2|Bacteria,1VEDY@1239|Firmicutes,24QPW@186801|Clostridia,36MPW@31979|Clostridiaceae	186801|Clostridia	S	Small acid-soluble spore	-	-	-	-	-	-	-	-	-	-	-	-	SASP
HKD2_k127_8201986_4	767817.Desgi_1279	1.642e-73	256.0	COG1408@1|root,COG1408@2|Bacteria,1UU17@1239|Firmicutes,248PS@186801|Clostridia,260P0@186807|Peptococcaceae	186801|Clostridia	S	PFAM Calcineurin-like phosphoesterase	-	-	-	ko:K07098	-	-	-	-	ko00000	-	-	-	Metallophos
HKD2_k127_8201986_7	717605.Theco_0716	1.16e-31	129.0	COG2201@1|root,COG2201@2|Bacteria,1V71X@1239|Firmicutes,4HITX@91061|Bacilli	91061|Bacilli	T	Chemotaxis protein CheY	yneI	-	-	ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	Response_reg
HKD2_k127_8201986_0	350688.Clos_1045	2.405e-206	651.0	COG2268@1|root,COG2268@2|Bacteria,1TQDT@1239|Firmicutes,247MK@186801|Clostridia,36DN3@31979|Clostridiaceae	186801|Clostridia	S	Band 7 protein	-	-	-	ko:K07192	ko04910,map04910	-	-	-	ko00000,ko00001,ko03036,ko04131,ko04147	-	-	-	Band_7,Flot
HKD2_k127_8201986_6	350688.Clos_1044	1.164e-42	166.0	COG1585@1|root,COG1585@2|Bacteria,1VD3E@1239|Firmicutes,24H38@186801|Clostridia,36IDP@31979|Clostridiaceae	186801|Clostridia	OU	Membrane protein implicated in regulation of membrane protease activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF1449,NfeD
HKD2_k127_8201986_5	767817.Desgi_2860	6.929e-66	231.0	COG0789@1|root,COG0789@2|Bacteria,1V1M9@1239|Firmicutes,24FUE@186801|Clostridia,262R5@186807|Peptococcaceae	186801|Clostridia	K	Domain of unknown function (DUF1836)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1836
HKD2_k127_8201986_2	858215.Thexy_0405	9.273e-84	281.0	COG1670@1|root,COG1670@2|Bacteria,1V1ZC@1239|Firmicutes,249K2@186801|Clostridia	186801|Clostridia	J	Acetyltransferase GNAT family	-	-	2.3.1.128	ko:K03790	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_3
HKD2_k127_8207495_9	1487921.DP68_01940	8.265e-148	469.0	COG0842@1|root,COG0842@2|Bacteria,1TS7U@1239|Firmicutes,24E30@186801|Clostridia,36H1P@31979|Clostridiaceae	186801|Clostridia	V	Transport permease protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
HKD2_k127_8207495_2	536227.CcarbDRAFT_4014	3.471e-223	700.0	COG0534@1|root,COG0534@2|Bacteria,1TNZN@1239|Firmicutes,247YX@186801|Clostridia,36DT9@31979|Clostridiaceae	186801|Clostridia	V	Mate efflux family protein	-	-	-	-	-	-	-	-	-	-	-	-	MatE
HKD2_k127_8207495_1	1209989.TepiRe1_0778	1.879e-226	710.0	COG0279@1|root,COG0546@1|root,COG0279@2|Bacteria,COG0546@2|Bacteria,1V2I1@1239|Firmicutes,24GTS@186801|Clostridia,42H01@68295|Thermoanaerobacterales	186801|Clostridia	G	Haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2,Hydrolase
HKD2_k127_8207495_8	1209989.TepiRe1_0779	6.611e-169	535.0	COG1915@1|root,COG1915@2|Bacteria,1UPP6@1239|Firmicutes,25HKD@186801|Clostridia	186801|Clostridia	S	PFAM LOR SDH bifunctional enzyme conserved region	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8207495_10	1209989.TepiRe1_0780	1.261e-144	465.0	COG2870@1|root,COG2870@2|Bacteria,1TSMF@1239|Firmicutes,24FJA@186801|Clostridia,42H15@68295|Thermoanaerobacterales	186801|Clostridia	H	ADP-heptose synthase, bifunctional sugar kinase adenylyltransferase	hldE	-	2.7.1.167,2.7.7.70	ko:K03272	ko00540,ko01100,map00540,map01100	M00064	R05644,R05646	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CTP_transf_like,PfkB
HKD2_k127_8207495_18	1123075.AUDP01000012_gene3496	7.989e-68	243.0	COG1063@1|root,COG1063@2|Bacteria,1VZEQ@1239|Firmicutes,253BU@186801|Clostridia	186801|Clostridia	E	Alcohol dehydrogenase GroES-like domain	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
HKD2_k127_8207495_6	1209989.TepiRe1_0781	1.161e-186	587.0	COG1879@1|root,COG1879@2|Bacteria,1V66Z@1239|Firmicutes,24HDK@186801|Clostridia	186801|Clostridia	G	Periplasmic binding protein domain	-	-	-	ko:K10439	ko02010,ko02030,map02010,map02030	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	Peripla_BP_4
HKD2_k127_8207495_0	1209989.TepiRe1_0782	1.209e-267	830.0	COG1129@1|root,COG1129@2|Bacteria,1TP6I@1239|Firmicutes,247II@186801|Clostridia,42FNU@68295|Thermoanaerobacterales	186801|Clostridia	P	Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system	-	-	3.6.3.17	ko:K10441	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	ABC_tran
HKD2_k127_8207495_15	545695.TREAZ_1011	1.644e-89	306.0	COG1172@1|root,COG1172@2|Bacteria,2J5S4@203691|Spirochaetes	203691|Spirochaetes	P	transport system permease	-	-	-	ko:K10440	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	BPD_transp_2
HKD2_k127_8207495_7	1209989.TepiRe1_0784	1.498e-185	584.0	COG0673@1|root,COG0673@2|Bacteria,1TQ72@1239|Firmicutes,24XW6@186801|Clostridia,42F0S@68295|Thermoanaerobacterales	186801|Clostridia	S	PFAM oxidoreductase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
HKD2_k127_8207495_3	1209989.TepiRe1_0785	2.689e-200	625.0	COG1082@1|root,COG1082@2|Bacteria,1TPJT@1239|Firmicutes,24A6G@186801|Clostridia,42FZ0@68295|Thermoanaerobacterales	186801|Clostridia	G	protein TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2,AP_endonuc_2_N
HKD2_k127_8207495_11	1209989.TepiRe1_0786	6.82e-137	442.0	COG1940@1|root,COG1940@2|Bacteria,1TPKW@1239|Firmicutes,248U9@186801|Clostridia,42FIY@68295|Thermoanaerobacterales	186801|Clostridia	G	PFAM ROK family protein	glcK	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS10220	ROK
HKD2_k127_8207495_17	585202.SMSK321_0550	1.279e-68	239.0	COG2148@1|root,COG2148@2|Bacteria,1TP7M@1239|Firmicutes,4HB3Z@91061|Bacilli,2TNW6@28037|Streptococcus mitis	91061|Bacilli	M	Bacterial sugar transferase	cpsE	-	-	-	-	-	-	-	-	-	-	-	Bac_transf,CoA_binding_3
HKD2_k127_8207495_4	1391646.AVSU01000050_gene1656	1.654e-193	612.0	COG0677@1|root,COG0677@2|Bacteria,1TPXY@1239|Firmicutes,248NW@186801|Clostridia	186801|Clostridia	M	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	capL	-	-	ko:K02474	ko00520,map00520	-	R06894	RC00291	ko00000,ko00001,ko01000,ko01005	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
HKD2_k127_8207495_12	398512.JQKC01000006_gene692	3.096e-134	434.0	COG0451@1|root,COG0451@2|Bacteria,1V34Y@1239|Firmicutes,25EDZ@186801|Clostridia,3WRT4@541000|Ruminococcaceae	186801|Clostridia	GM	NmrA-like family	-	-	5.1.3.2,5.1.3.20,5.1.3.7	ko:K01784,ko:K02473,ko:K03274	ko00052,ko00520,ko00540,ko01100,map00052,map00520,map00540,map01100	M00064,M00361,M00362,M00632	R00291,R00418,R02984,R05176	RC00289,RC01291	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Epimerase,GDP_Man_Dehyd
HKD2_k127_8207495_13	1301100.HG529225_gene4220	1.472e-125	413.0	COG0438@1|root,COG0438@2|Bacteria,1TPY6@1239|Firmicutes,24834@186801|Clostridia,36H9V@31979|Clostridiaceae	186801|Clostridia	M	Glycosyl transferase 4-like	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_4_2,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
HKD2_k127_8207495_16	330214.NIDE2698	4.97e-74	260.0	COG0726@1|root,COG0726@2|Bacteria	2|Bacteria	G	polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
HKD2_k127_8207495_14	946235.CAER01000012_gene178	2.439e-108	362.0	COG0438@1|root,COG0438@2|Bacteria,1V0AQ@1239|Firmicutes,4HEBD@91061|Bacilli	91061|Bacilli	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glycos_transf_1
HKD2_k127_8207495_19	358681.BBR47_42510	3.595e-63	233.0	2CFJX@1|root,33270@2|Bacteria,1VG2G@1239|Firmicutes	1239|Firmicutes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8207495_20	195103.CPF_0917	7.071e-36	146.0	COG3475@1|root,COG3475@2|Bacteria,1VBSV@1239|Firmicutes,24C5H@186801|Clostridia,36EWJ@31979|Clostridiaceae	186801|Clostridia	M	LICD family	-	-	-	ko:K07271	-	-	-	-	ko00000,ko01000	-	-	-	LicD
HKD2_k127_8207495_5	1347392.CCEZ01000075_gene3192	1.337e-188	597.0	COG0615@1|root,COG0673@1|root,COG0615@2|Bacteria,COG0673@2|Bacteria,1V3KY@1239|Firmicutes,24BKY@186801|Clostridia,36VGY@31979|Clostridiaceae	186801|Clostridia	IM	Glycerol-3-phosphate cytidylyltransferase	tagD	-	2.7.7.39	ko:K00980	ko00564,map00564	-	R00856	RC00002	ko00000,ko00001,ko01000	-	-	-	CTP_transf_like,GFO_IDH_MocA
HKD2_k127_8211355_0	1408422.JHYF01000011_gene3404	2.626e-259	806.0	COG0459@1|root,COG0459@2|Bacteria,1TP1T@1239|Firmicutes,248BG@186801|Clostridia,36E1F@31979|Clostridiaceae	186801|Clostridia	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
HKD2_k127_8211355_3	1209989.TepiRe1_0435	2.912e-42	156.0	COG0234@1|root,COG0234@2|Bacteria,1V9ZM@1239|Firmicutes,24MMM@186801|Clostridia,42GV4@68295|Thermoanaerobacterales	186801|Clostridia	O	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter	groS	-	-	ko:K04078	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Cpn10
HKD2_k127_8211355_1	1123009.AUID01000019_gene217	7.177e-73	254.0	COG1811@1|root,COG1811@2|Bacteria,1UH19@1239|Firmicutes,24AZ3@186801|Clostridia,2692B@186813|unclassified Clostridiales	186801|Clostridia	S	Protein of unknown function (DUF554)	-	-	-	ko:K07150	-	-	-	-	ko00000	-	-	-	DUF554
HKD2_k127_8211355_2	1121324.CLIT_20c00260	1.057e-45	168.0	COG0122@1|root,COG0122@2|Bacteria,1TQAF@1239|Firmicutes,2495X@186801|Clostridia,25QV1@186804|Peptostreptococcaceae	186801|Clostridia	L	8-oxoguanine DNA glycosylase, N-terminal domain	alkA	-	4.2.99.18	ko:K03660	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD,OGG_N
HKD2_k127_8246437_0	1131462.DCF50_p2820	2.747e-120	402.0	COG2120@1|root,COG2120@2|Bacteria,1TQM2@1239|Firmicutes,24EYU@186801|Clostridia,262YI@186807|Peptococcaceae	186801|Clostridia	S	GlcNAc-PI de-N-acetylase	-	-	-	-	-	-	-	-	-	-	-	-	F5_F8_type_C,PIG-L
HKD2_k127_8246437_2	697281.Mahau_2861	2.275e-20	99.0	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	DUF3579
HKD2_k127_8246437_1	386415.NT01CX_0711	1.28e-58	209.0	COG2715@1|root,COG2715@2|Bacteria,1V1E2@1239|Firmicutes,249G0@186801|Clostridia,36E11@31979|Clostridiaceae	186801|Clostridia	S	Spore maturation protein	spmA	-	-	ko:K06373	-	-	-	-	ko00000	-	-	-	Gate
HKD2_k127_8246437_3	1033737.CAEV01000043_gene1423	1.173e-17	88.0	COG0700@1|root,COG0700@2|Bacteria,1V45M@1239|Firmicutes,24HSJ@186801|Clostridia,36HZ1@31979|Clostridiaceae	186801|Clostridia	S	Spore maturation protein	spmB	-	-	ko:K06374	-	-	-	-	ko00000	-	-	-	Gate
HKD2_k127_8280132_2	1449063.JMLS01000013_gene5978	1.164e-06	51.0	2DJMR@1|root,306KE@2|Bacteria,1TZYH@1239|Firmicutes,4I982@91061|Bacilli,2715K@186822|Paenibacillaceae	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8280132_0	857293.CAAU_1095	1.434e-122	411.0	COG0793@1|root,COG0793@2|Bacteria,1V2B2@1239|Firmicutes,24A3A@186801|Clostridia,36EJR@31979|Clostridiaceae	186801|Clostridia	M	Peptidase family S41	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S41,Tricorn_C1
HKD2_k127_8280132_1	318464.IO99_12125	1.803e-20	97.0	2DK45@1|root,308DR@2|Bacteria,1V4G7@1239|Firmicutes,25D8R@186801|Clostridia	186801|Clostridia	S	Zinc dependent phospholipase C	-	-	-	-	-	-	-	-	-	-	-	-	Zn_dep_PLPC
HKD2_k127_8283915_2	1128398.Curi_c25830	4.04e-64	223.0	COG1595@1|root,COG1595@2|Bacteria,1V734@1239|Firmicutes,24MQB@186801|Clostridia,268VU@186813|unclassified Clostridiales	186801|Clostridia	K	Sigma-70, region 4	sigV	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD2_k127_8283915_1	1209989.TepiRe1_1110	2.79e-116	381.0	2DBFK@1|root,2Z8Z7@2|Bacteria,1TQKG@1239|Firmicutes,2482J@186801|Clostridia	186801|Clostridia	S	Protein of unknown function (DUF3298)	rsiV	-	-	-	-	-	-	-	-	-	-	-	DUF3298,DUF4163
HKD2_k127_8283915_0	498761.HM1_0850	1.982e-177	563.0	COG0172@1|root,COG0172@2|Bacteria,1TP4W@1239|Firmicutes,2485M@186801|Clostridia	186801|Clostridia	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Seryl_tRNA_N,tRNA-synt_2b
HKD2_k127_8293158_2	555088.DealDRAFT_0517	2.626e-16	79.0	COG1595@1|root,COG1595@2|Bacteria,1V98V@1239|Firmicutes,25BR6@186801|Clostridia	186801|Clostridia	K	Sigma-70, region 4	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r4_2
HKD2_k127_8293158_0	290402.Cbei_0719	4.161e-135	436.0	COG2801@1|root,COG2801@2|Bacteria,1TQEG@1239|Firmicutes,25B5A@186801|Clostridia,36FD0@31979|Clostridiaceae	186801|Clostridia	L	hmm pf00665	-	-	-	-	-	-	-	-	-	-	-	-	HTH_21,rve,rve_2
HKD2_k127_8293158_1	1345695.CLSA_c10590	5.444e-82	278.0	COG2963@1|root,COG2963@2|Bacteria,1V4FD@1239|Firmicutes,24GUY@186801|Clostridia,36I6D@31979|Clostridiaceae	186801|Clostridia	L	hmm pf01527	-	-	-	-	-	-	-	-	-	-	-	-	HTH_28,HTH_Tnp_1
HKD2_k127_8314993_4	871968.DESME_00490	1.521e-21	97.0	COG0398@1|root,COG0398@2|Bacteria,1V3DJ@1239|Firmicutes,24G6T@186801|Clostridia,265X4@186807|Peptococcaceae	186801|Clostridia	S	SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
HKD2_k127_8314993_3	768710.DesyoDRAFT_5097	1.582e-39	163.0	COG2733@1|root,COG2733@2|Bacteria,1V1AB@1239|Firmicutes,24G52@186801|Clostridia,261HD@186807|Peptococcaceae	186801|Clostridia	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF445
HKD2_k127_8314993_2	931276.Cspa_c28830	1.225e-39	162.0	COG2733@1|root,COG2733@2|Bacteria,1TS8F@1239|Firmicutes,24GP2@186801|Clostridia,36JDE@31979|Clostridiaceae	186801|Clostridia	S	Protein of unknown function (DUF445)	-	-	-	-	-	-	-	-	-	-	-	-	DUF445
HKD2_k127_8314993_1	1487921.DP68_15495	1.083e-220	696.0	COG3829@1|root,COG3829@2|Bacteria,1TP0E@1239|Firmicutes,247MB@186801|Clostridia,36EY7@31979|Clostridiaceae	186801|Clostridia	KT	Bacterial regulatory protein, Fis family	-	-	-	ko:K06714	-	-	-	-	ko00000,ko03000	-	-	-	HTH_8,PAS,PAS_4,PAS_8,PAS_9,Sigma54_activat
HKD2_k127_8314993_0	1487921.DP68_15490	5.546e-224	699.0	COG1292@1|root,COG1292@2|Bacteria,1TRS6@1239|Firmicutes,2482K@186801|Clostridia,36E19@31979|Clostridiaceae	186801|Clostridia	M	Belongs to the BCCT transporter (TC 2.A.15) family	-	-	-	ko:K02168,ko:K05020	-	-	-	-	ko00000,ko02000	2.A.15.1.1,2.A.15.1.11,2.A.15.1.3,2.A.15.1.4	-	-	BCCT
HKD2_k127_8335966_2	1487921.DP68_14190	1.1e-44	168.0	2F9HQ@1|root,341U6@2|Bacteria,1VYFD@1239|Firmicutes,24IPU@186801|Clostridia,36IPS@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8335966_1	646529.Desaci_1704	2.72e-303	941.0	COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247Q0@186801|Clostridia,260DJ@186807|Peptococcaceae	186801|Clostridia	V	ABC-type multidrug transport system ATPase and permease	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
HKD2_k127_8335966_0	580327.Tthe_2606	0.0	1049.0	COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247T8@186801|Clostridia,42FRT@68295|Thermoanaerobacterales	186801|Clostridia	P	ABC transporter, transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
HKD2_k127_8335966_3	580327.Tthe_2607	4.293e-43	160.0	COG1846@1|root,COG1846@2|Bacteria,1V3P7@1239|Firmicutes,24IJX@186801|Clostridia,42GGP@68295|Thermoanaerobacterales	186801|Clostridia	K	PFAM regulatory protein, MarR	-	-	-	-	-	-	-	-	-	-	-	-	MarR
HKD2_k127_8481653_3	1122927.KB895418_gene2838	3.479e-130	421.0	COG2132@1|root,COG2132@2|Bacteria,1TQJK@1239|Firmicutes,4HG57@91061|Bacilli,26VB4@186822|Paenibacillaceae	91061|Bacilli	Q	Multicopper oxidase	-	-	1.16.3.3	ko:K22348	-	-	-	-	ko00000,ko01000	-	-	-	Cu-oxidase_2,Cu-oxidase_3
HKD2_k127_8481653_5	931276.Cspa_c19920	4.141e-80	295.0	COG0642@1|root,COG2205@2|Bacteria,1TQMV@1239|Firmicutes,247SE@186801|Clostridia,36ERF@31979|Clostridiaceae	186801|Clostridia	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,dCache_1
HKD2_k127_8481653_7	1511.CLOST_0670	5.919e-63	237.0	COG2199@1|root,COG2206@1|root,COG2199@2|Bacteria,COG2206@2|Bacteria,1V6WM@1239|Firmicutes,25E5R@186801|Clostridia	186801|Clostridia	T	Diguanylate cyclase (GGDEF) domain	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,HD,HD_5,PAS_3,PAS_9,PocR
HKD2_k127_8481653_8	1168034.FH5T_20815	3.081e-33	147.0	COG2199@1|root,COG4251@1|root,COG3706@2|Bacteria,COG4251@2|Bacteria,4PN7F@976|Bacteroidetes,2G14N@200643|Bacteroidia	976|Bacteroidetes	T	Response regulator receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg
HKD2_k127_8481653_4	756499.Desde_1474	1.621e-122	404.0	COG3947@1|root,COG3947@2|Bacteria,1V85E@1239|Firmicutes,24ENV@186801|Clostridia,263EB@186807|Peptococcaceae	186801|Clostridia	K	Response regulator containing CheY-like receiver and SARP domains	-	-	-	-	-	-	-	-	-	-	-	-	BTAD,Response_reg,Trans_reg_C
HKD2_k127_8481653_1	1195236.CTER_2294	9.481e-246	790.0	COG5001@1|root,COG5001@2|Bacteria,1TP8V@1239|Firmicutes,247PX@186801|Clostridia,3WNHQ@541000|Ruminococcaceae	186801|Clostridia	T	Putative diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	ABC_sub_bind,EAL,GGDEF,PAS_3,PAS_9,PocR
HKD2_k127_8481653_0	1487921.DP68_10925	1.587e-260	818.0	COG0840@1|root,COG0840@2|Bacteria,1TP5A@1239|Firmicutes,247S3@186801|Clostridia,36EQK@31979|Clostridiaceae	186801|Clostridia	NT	chemotaxis	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	HAMP,MCPsignal,dCache_1
HKD2_k127_8481653_2	1304284.L21TH_2712	1.556e-177	578.0	COG3829@1|root,COG3829@2|Bacteria,1TP0E@1239|Firmicutes,247MB@186801|Clostridia,36DY7@31979|Clostridiaceae	186801|Clostridia	KT	PFAM sigma-54 factor interaction domain-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_12,HTH_8,PAS,PAS_9,Sigma54_activat
HKD2_k127_8481653_6	1009370.ALO_00705	4.098e-75	256.0	COG0044@1|root,COG0044@2|Bacteria,1TPI6@1239|Firmicutes,4H9F2@909932|Negativicutes	909932|Negativicutes	F	Catalyzes the hydrolytic cleavage of a subset of L- isoaspartyl (L-beta-aspartyl) dipeptides. Used to degrade proteins damaged by L-isoaspartyl residues formation	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
HKD2_k127_8579801_0	1286171.EAL2_808p05370	1.234e-163	531.0	COG3973@1|root,COG3973@2|Bacteria,1TP39@1239|Firmicutes,249IG@186801|Clostridia,25VKS@186806|Eubacteriaceae	186801|Clostridia	L	UvrD-like helicase C-terminal domain	-	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AAA_19,UvrD-helicase,UvrD_C,UvrD_C_2
HKD2_k127_8579801_1	1391646.AVSU01000001_gene241	1.081e-157	501.0	COG0191@1|root,COG0191@2|Bacteria,1TQ01@1239|Firmicutes,248B7@186801|Clostridia,25R5K@186804|Peptostreptococcaceae	186801|Clostridia	G	Fructose-bisphosphate aldolase class-II	fba	-	4.1.2.13	ko:K01624	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167,M00344,M00345	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	F_bP_aldolase
HKD2_k127_8579801_2	1499689.CCNN01000014_gene3270	1.055e-74	255.0	2B66C@1|root,31Z3H@2|Bacteria,1V6U0@1239|Firmicutes,24ICU@186801|Clostridia,36J7Y@31979|Clostridiaceae	186801|Clostridia	S	Psort location Cytoplasmic, score 8.87	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_872525_7	340099.Teth39_1790	6.95e-117	378.0	COG0192@1|root,COG0192@2|Bacteria,1TPCV@1239|Firmicutes,248QF@186801|Clostridia,42ESY@68295|Thermoanaerobacterales	186801|Clostridia	H	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme	metK	-	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
HKD2_k127_872525_0	1304284.L21TH_2580	1.318e-274	862.0	COG0507@1|root,COG0507@2|Bacteria,1TPZH@1239|Firmicutes,247R7@186801|Clostridia,36ER3@31979|Clostridiaceae	186801|Clostridia	L	DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity	recD2	-	3.1.11.5	ko:K03581	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AAA_30,HHH_4,HHH_5,UvrD_C_2
HKD2_k127_872525_15	580327.Tthe_2199	2.334e-43	167.0	COG1040@1|root,COG1040@2|Bacteria,1VF2G@1239|Firmicutes,24IG6@186801|Clostridia,42FNR@68295|Thermoanaerobacterales	186801|Clostridia	F	PFAM Phosphoribosyltransferase	comF	-	-	ko:K02242	-	M00429	-	-	ko00000,ko00002,ko02044	-	-	-	Pribosyltran
HKD2_k127_872525_18	350688.Clos_2524	1.045e-39	151.0	2D61I@1|root,32TKA@2|Bacteria,1VB5H@1239|Firmicutes,24NZW@186801|Clostridia,36MAF@31979|Clostridiaceae	186801|Clostridia	N	TIGRFAM flagellar operon protein	yvyF	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_872525_26	1280696.ATVY01000014_gene2059	4.992e-08	58.0	COG2747@1|root,COG2747@2|Bacteria,1VFH9@1239|Firmicutes,24QZ8@186801|Clostridia,4BZQS@830|Butyrivibrio	186801|Clostridia	KNU	Anti-sigma-28 factor, FlgM	flgM	-	-	ko:K02398	ko02020,ko02025,ko02026,ko02040,map02020,map02025,map02026,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FlgM
HKD2_k127_872525_22	588581.Cpap_2164	1.813e-23	106.0	COG3418@1|root,COG3418@2|Bacteria,1VF67@1239|Firmicutes,24SF3@186801|Clostridia	186801|Clostridia	NOU	PFAM FlgN	-	-	-	-	-	-	-	-	-	-	-	-	FlgN
HKD2_k127_872525_9	1304284.L21TH_2575	7.668e-100	342.0	COG1256@1|root,COG1256@2|Bacteria,1TPXH@1239|Firmicutes,249PE@186801|Clostridia,36DE8@31979|Clostridiaceae	186801|Clostridia	N	flagellar hook-associated protein	flgK	-	-	ko:K02396	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod,Flg_bbr_C,VWA
HKD2_k127_872525_6	1121289.JHVL01000009_gene1411	4.439e-121	405.0	COG1256@1|root,COG1256@2|Bacteria,1TPXH@1239|Firmicutes,249PE@186801|Clostridia,36DE8@31979|Clostridiaceae	186801|Clostridia	N	flagellar hook-associated protein	flgK	-	-	ko:K02396	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod,Flg_bbr_C
HKD2_k127_872525_11	1304284.L21TH_2572	2.022e-89	304.0	COG1344@1|root,COG1344@2|Bacteria,1TPDT@1239|Firmicutes,248FN@186801|Clostridia,36FHE@31979|Clostridiaceae	186801|Clostridia	N	Belongs to the bacterial flagellin family	flgL	-	-	ko:K02397	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flagellin_C,Flagellin_N
HKD2_k127_872525_17	340099.Teth39_1782	3.847e-41	158.0	2D8PV@1|root,32TRS@2|Bacteria,1V1NF@1239|Firmicutes,24AEP@186801|Clostridia,42G0M@68295|Thermoanaerobacterales	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_872525_21	1033734.CAET01000039_gene333	1.864e-30	125.0	COG1699@1|root,COG1699@2|Bacteria,1VA6Y@1239|Firmicutes,4HKYD@91061|Bacilli,1ZI2D@1386|Bacillus	91061|Bacilli	S	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum	fliW	-	-	ko:K13626	-	-	-	-	ko00000,ko02035	-	-	-	FliW
HKD2_k127_872525_25	1449126.JQKL01000003_gene1776	7.097e-14	73.0	COG1551@1|root,COG1551@2|Bacteria,1VEEF@1239|Firmicutes,24QPD@186801|Clostridia,269V3@186813|unclassified Clostridiales	186801|Clostridia	T	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding	csrA	-	-	ko:K03563	ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03019	-	-	-	CsrA
HKD2_k127_872525_8	350688.Clos_2518	2.055e-116	381.0	COG1344@1|root,COG1344@2|Bacteria,1TP1K@1239|Firmicutes,247JQ@186801|Clostridia,36ED6@31979|Clostridiaceae	186801|Clostridia	N	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella	fliC	-	-	ko:K02406	ko02020,ko02040,ko04621,ko04626,ko05132,ko05134,map02020,map02040,map04621,map04626,map05132,map05134	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flagellin_C,Flagellin_N
HKD2_k127_872525_4	350688.Clos_2517	1.727e-138	461.0	COG2604@1|root,COG2604@2|Bacteria,1U2BC@1239|Firmicutes,24CSU@186801|Clostridia,36G68@31979|Clostridiaceae	186801|Clostridia	S	Protein of unknown function DUF115	-	-	-	-	-	-	-	-	-	-	-	-	MAF_flag10
HKD2_k127_872525_23	1443125.Z962_09420	1.723e-20	96.0	2EI2Q@1|root,33BU4@2|Bacteria,1VKQD@1239|Firmicutes,24QY0@186801|Clostridia,36MWB@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_872525_13	1134413.ANNK01000034_gene1260	4.601e-80	282.0	COG0727@1|root,COG0727@2|Bacteria,1TSB6@1239|Firmicutes,4HFAZ@91061|Bacilli,1ZKM1@1386|Bacillus	91061|Bacilli	S	Psort location Cytoplasmic, score	-	-	-	ko:K18475	-	-	-	-	ko00000,ko01000,ko02035	-	-	-	-
HKD2_k127_872525_1	350688.Clos_2515	1.335e-182	575.0	COG1086@1|root,COG1086@2|Bacteria,1TPTC@1239|Firmicutes,247YC@186801|Clostridia,36VQ0@31979|Clostridiaceae	186801|Clostridia	M	biosynthesis protein	pseB	-	4.2.1.115	ko:K15894	ko00520,map00520	-	R09697	RC02609	ko00000,ko00001,ko01000	-	-	-	Polysacc_synt_2
HKD2_k127_872525_12	350688.Clos_2513	1.444e-80	274.0	COG1861@1|root,COG1861@2|Bacteria,1U4YD@1239|Firmicutes,24B0X@186801|Clostridia,36GFB@31979|Clostridiaceae	186801|Clostridia	M	Cytidylyltransferase	spsF	-	-	ko:K07257	-	-	-	-	ko00000	-	-	-	CTP_transf_3
HKD2_k127_872525_14	350688.Clos_2511	1.984e-56	200.0	COG1670@1|root,COG1670@2|Bacteria,1VH5J@1239|Firmicutes	1239|Firmicutes	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
HKD2_k127_872525_2	865861.AZSU01000002_gene2985	4.871e-181	570.0	COG2089@1|root,COG2089@2|Bacteria,1TS09@1239|Firmicutes,249DN@186801|Clostridia,36F2S@31979|Clostridiaceae	186801|Clostridia	M	synthase	pseI	-	2.5.1.56,2.5.1.97	ko:K01654,ko:K15898	ko00520,ko01100,map00520,map01100	-	R01804,R04435,R09841	RC00159	ko00000,ko00001,ko01000	-	-	-	NeuB,SAF
HKD2_k127_872525_10	865861.AZSU01000002_gene2986	1.531e-93	318.0	COG3980@1|root,COG3980@2|Bacteria,1U2ZW@1239|Firmicutes,24HWM@186801|Clostridia,36G5R@31979|Clostridiaceae	186801|Clostridia	M	pseudaminic acid biosynthesis-associated protein PseG	pseG	-	3.6.1.57	ko:K15897	ko00520,map00520	-	R09834	RC00005,RC00078	ko00000,ko00001,ko01000	-	-	-	Glyco_tran_28_C
HKD2_k127_872525_3	865861.AZSU01000002_gene2980	9.373e-178	563.0	COG0399@1|root,COG0399@2|Bacteria,1TPDH@1239|Firmicutes,24862@186801|Clostridia,36ENR@31979|Clostridiaceae	186801|Clostridia	E	Belongs to the DegT DnrJ EryC1 family	pseC	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
HKD2_k127_872525_20	398512.JQKC01000002_gene1902	2.556e-31	126.0	COG1334@1|root,COG1334@2|Bacteria,1VFRY@1239|Firmicutes,24QPX@186801|Clostridia,3WPZZ@541000|Ruminococcaceae	186801|Clostridia	N	FlaG protein	flaG	-	-	ko:K06603	-	-	-	-	ko00000,ko02035	-	-	-	FlaG
HKD2_k127_872525_5	398512.JQKC01000002_gene1903	1.699e-133	447.0	COG1345@1|root,COG1345@2|Bacteria,1TQ66@1239|Firmicutes,248Q9@186801|Clostridia,3WI8H@541000|Ruminococcaceae	186801|Clostridia	N	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end	fliD	-	-	ko:K02407	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flagellin_IN,FliD_C,FliD_N
HKD2_k127_872525_16	394503.Ccel_0106	3.847e-41	158.0	COG1516@1|root,COG1516@2|Bacteria,1VA8K@1239|Firmicutes,24MRW@186801|Clostridia,36JGU@31979|Clostridiaceae	186801|Clostridia	N	flagellar protein FliS	fliS	-	-	ko:K02422	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliS
HKD2_k127_872525_19	697281.Mahau_2724	9.139e-37	142.0	COG1278@1|root,COG1278@2|Bacteria,1VBBH@1239|Firmicutes,24QK9@186801|Clostridia,42GTD@68295|Thermoanaerobacterales	186801|Clostridia	K	Probable zinc-ribbon domain	-	-	-	-	-	-	-	-	-	-	-	-	zf-trcl
HKD2_k127_878661_0	913865.DOT_6283	1.082e-238	746.0	COG0446@1|root,COG0607@1|root,COG2210@1|root,COG0446@2|Bacteria,COG0607@2|Bacteria,COG2210@2|Bacteria,1TPWW@1239|Firmicutes,2484C@186801|Clostridia,2606T@186807|Peptococcaceae	186801|Clostridia	P	pyridine nucleotide-disulphide oxidoreductase dimerisation	cdr	-	-	-	-	-	-	-	-	-	-	-	DrsE_2,Pyr_redox_2,Pyr_redox_dim,Rhodanese,TusA
HKD2_k127_878661_3	868595.Desca_0677	9.087e-33	129.0	COG0640@1|root,COG0640@2|Bacteria,1VF14@1239|Firmicutes,24MW7@186801|Clostridia,262SE@186807|Peptococcaceae	186801|Clostridia	K	helix_turn_helix, Arsenical Resistance Operon Repressor	pagR	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
HKD2_k127_878661_1	370438.PTH_1734	1.391e-196	627.0	COG0446@1|root,COG0607@1|root,COG0446@2|Bacteria,COG0607@2|Bacteria,1TPWW@1239|Firmicutes,2484C@186801|Clostridia,2606T@186807|Peptococcaceae	186801|Clostridia	P	pyridine nucleotide-disulphide oxidoreductase dimerisation	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,NIR_SIR,NIR_SIR_ferr,Pyr_redox_2,Pyr_redox_dim,Rhodanese
HKD2_k127_878661_4	1449126.JQKL01000002_gene1612	9.037e-26	107.0	COG0425@1|root,COG0425@2|Bacteria,1VHQI@1239|Firmicutes,24TWT@186801|Clostridia	186801|Clostridia	O	Belongs to the sulfur carrier protein TusA family	-	-	-	-	-	-	-	-	-	-	-	-	TusA
HKD2_k127_878661_2	1449126.JQKL01000030_gene2506	2.185e-41	154.0	COG2210@1|root,COG2210@2|Bacteria,1UIFM@1239|Firmicutes,24H1I@186801|Clostridia	186801|Clostridia	S	DsrE/DsrF/DrsH-like family	-	-	-	-	-	-	-	-	-	-	-	-	DrsE_2
HKD2_k127_8889434_1	1347392.CCEZ01000016_gene2929	1.396e-60	234.0	COG1173@1|root,COG1173@2|Bacteria,1V21B@1239|Firmicutes,2498X@186801|Clostridia,36GUS@31979|Clostridiaceae	186801|Clostridia	EP	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,Peptidase_M28
HKD2_k127_8889434_0	1487921.DP68_17275	4.218e-73	251.0	COG0483@1|root,COG0483@2|Bacteria,1TR4E@1239|Firmicutes,24KJZ@186801|Clostridia,36JCB@31979|Clostridiaceae	186801|Clostridia	G	Inositol monophosphatase	-	-	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
HKD2_k127_8905569_3	589924.Ferp_0678	7.262e-05	55.0	COG3979@1|root,arCOG07581@2157|Archaea,2Y78D@28890|Euryarchaeota,247FP@183980|Archaeoglobi	183980|Archaeoglobi	G	PKD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8905569_1	1031288.AXAA01000004_gene1945	4.057e-126	407.0	COG5012@1|root,COG5012@2|Bacteria,1UJB2@1239|Firmicutes,25F0A@186801|Clostridia,36EPZ@31979|Clostridiaceae	186801|Clostridia	S	Dimerisation domain of d-ornithine 4,5-aminomutase	-	-	5.4.3.3	ko:K18011	ko00310,map00310	-	R02852,R03275	RC00719	ko00000,ko00001,ko01000	-	-	-	B12-binding,OAM_dimer
HKD2_k127_8905569_0	1304284.L21TH_0212	1.306e-261	812.0	COG0274@1|root,COG0274@2|Bacteria,1TPA0@1239|Firmicutes,249YN@186801|Clostridia,36F7D@31979|Clostridiaceae	186801|Clostridia	F	D-Lysine 5,6-aminomutase TIM-barrel domain of alpha subunit	kamD	-	5.4.3.3	ko:K01844	ko00310,map00310	-	R02852,R03275	RC00719	ko00000,ko00001,ko01000	-	-	-	Lys-AminoMut_A
HKD2_k127_8905569_2	1304284.L21TH_0213	1.083e-82	287.0	COG1193@1|root,COG1193@2|Bacteria,1TSBW@1239|Firmicutes,24814@186801|Clostridia,36FV5@31979|Clostridiaceae	186801|Clostridia	L	ATPase domain of DNA mismatch repair MUTS family	-	-	-	ko:K07456	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_V
HKD2_k127_8952581_0	398512.JQKC01000002_gene2035	3.368e-204	640.0	COG0148@1|root,COG0148@2|Bacteria,1TP2S@1239|Firmicutes,247TU@186801|Clostridia,3WGBH@541000|Ruminococcaceae	186801|Clostridia	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
HKD2_k127_8952581_4	1120998.AUFC01000001_gene1835	1.017e-14	76.0	COG1314@1|root,COG1314@2|Bacteria,1U4FP@1239|Firmicutes,24R3X@186801|Clostridia,3WDKU@538999|Clostridiales incertae sedis	186801|Clostridia	U	Preprotein translocase SecG subunit	secG	-	-	ko:K03075	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecG
HKD2_k127_8952581_3	1226325.HMPREF1548_04921	1.242e-26	111.0	COG3326@1|root,COG3326@2|Bacteria,1VEJY@1239|Firmicutes,24QJW@186801|Clostridia,36MRK@31979|Clostridiaceae	186801|Clostridia	S	Protein of unknown function (DUF1294)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1294
HKD2_k127_8952581_2	1304284.L21TH_1208	1.291e-72	253.0	COG1647@1|root,COG1647@2|Bacteria,1TQ7X@1239|Firmicutes,24HZH@186801|Clostridia,36G4R@31979|Clostridiaceae	186801|Clostridia	S	Serine aminopeptidase, S33	-	-	3.1.1.1	ko:K03928	-	-	-	-	ko00000,ko01000	-	-	-	Hydrolase_4
HKD2_k127_8952581_1	720554.Clocl_1197	1.364e-81	278.0	COG0557@1|root,COG0557@2|Bacteria,1TQ1G@1239|Firmicutes,247ZS@186801|Clostridia,3WGHJ@541000|Ruminococcaceae	186801|Clostridia	J	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs	rnr	-	-	ko:K12573	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	OB_RNB,RNB,S1
HKD2_k127_895466_6	526218.Sterm_2197	4.012e-05	55.0	COG1192@1|root,COG1192@2|Bacteria,37ARP@32066|Fusobacteria	32066|Fusobacteria	D	CobQ CobB MinD ParA nucleotide binding domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_31
HKD2_k127_895466_5	743719.PaelaDRAFT_2816	4.473e-07	61.0	COG1192@1|root,COG1192@2|Bacteria,1V47U@1239|Firmicutes,4HHBK@91061|Bacilli,26WX5@186822|Paenibacillaceae	91061|Bacilli	D	Involved in chromosome partitioning	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_895466_0	1395587.P364_0123715	2.396e-26	125.0	COG4962@1|root,COG4962@2|Bacteria,1TQE3@1239|Firmicutes,4HB5R@91061|Bacilli,26SVQ@186822|Paenibacillaceae	91061|Bacilli	U	Pilus assembly protein	-	-	-	ko:K02283	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
HKD2_k127_895466_3	743719.PaelaDRAFT_3825	2.138e-12	76.0	28K4V@1|root,2Z9TN@2|Bacteria,1TT6X@1239|Firmicutes,4HDQP@91061|Bacilli,26SMN@186822|Paenibacillaceae	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_895466_1	203119.Cthe_2186	3.133e-18	88.0	COG0629@1|root,COG0629@2|Bacteria,1V3WT@1239|Firmicutes,24HF9@186801|Clostridia,3WJ32@541000|Ruminococcaceae	186801|Clostridia	L	Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism	ssb	-	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
HKD2_k127_895466_4	865861.AZSU01000002_gene2733	1.357e-09	64.0	COG1943@1|root,COG1943@2|Bacteria,1V6R5@1239|Firmicutes,24NQE@186801|Clostridia,36VW5@31979|Clostridiaceae	186801|Clostridia	L	Transposase IS200 like	-	-	-	-	-	-	-	-	-	-	-	-	Bac_DnaA_C,Y1_Tnp
HKD2_k127_895466_2	1121335.Clst_1736	5.538e-13	75.0	COG0791@1|root,COG0791@2|Bacteria,1VCXA@1239|Firmicutes,24P8U@186801|Clostridia	186801|Clostridia	M	S-layer homology domain	-	-	-	-	-	-	-	-	-	-	-	-	SLH
HKD2_k127_8963615_7	1408422.JHYF01000004_gene1566	1.528e-19	90.0	COG2721@1|root,COG2721@2|Bacteria,1TPTX@1239|Firmicutes,24AEC@186801|Clostridia,36G4P@31979|Clostridiaceae	186801|Clostridia	G	D-galactarate dehydratase altronate hydrolase	uxaA	-	4.2.1.7	ko:K01685	ko00040,ko01100,map00040,map01100	M00631	R01540	RC00543	ko00000,ko00001,ko00002,ko01000	-	-	-	GD_AH_C,SAF
HKD2_k127_8963615_2	1408422.JHYF01000004_gene1565	3.402e-239	746.0	COG0246@1|root,COG0246@2|Bacteria,1TPZU@1239|Firmicutes,248J5@186801|Clostridia,36FPY@31979|Clostridiaceae	186801|Clostridia	G	Belongs to the mannitol dehydrogenase family. UxaB subfamily	uxaB	-	1.1.1.58	ko:K00041	ko00040,ko01100,map00040,map01100	M00631	R02555	RC00085	ko00000,ko00001,ko00002,ko01000	-	-	-	Mannitol_dh,Mannitol_dh_C
HKD2_k127_8963615_4	357809.Cphy_1132	4.844e-127	414.0	COG1879@1|root,COG1879@2|Bacteria,1V5XB@1239|Firmicutes,24E4G@186801|Clostridia,223TF@1506553|Lachnoclostridium	186801|Clostridia	G	Periplasmic binding protein domain	-	-	-	ko:K10439	ko02010,ko02030,map02010,map02030	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	Peripla_BP_4
HKD2_k127_8963615_3	357809.Cphy_1133	7.138e-133	431.0	COG1172@1|root,COG1172@2|Bacteria,1TP72@1239|Firmicutes,249FA@186801|Clostridia,21XEX@1506553|Lachnoclostridium	186801|Clostridia	G	Psort location CytoplasmicMembrane, score 10.00	-	-	-	ko:K10440	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	BPD_transp_2
HKD2_k127_8963615_1	357809.Cphy_1134	4.602e-252	785.0	COG1129@1|root,COG1129@2|Bacteria,1TP6I@1239|Firmicutes,247II@186801|Clostridia,21XJ5@1506553|Lachnoclostridium	186801|Clostridia	P	Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system	-	-	3.6.3.17	ko:K10441	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	ABC_tran
HKD2_k127_8963615_0	1268072.PSAB_22935	6.129e-268	833.0	COG0129@1|root,COG0129@2|Bacteria,1TP1R@1239|Firmicutes,4H9ZG@91061|Bacilli,26RAG@186822|Paenibacillaceae	91061|Bacilli	E	Belongs to the IlvD Edd family	-	-	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
HKD2_k127_8963615_5	1321778.HMPREF1982_01584	6.911e-125	405.0	COG1737@1|root,COG1737@2|Bacteria,1TR0N@1239|Firmicutes,24BR4@186801|Clostridia	186801|Clostridia	K	transcriptional regulator (RpiR family)	-	-	-	-	-	-	-	-	-	-	-	-	HTH_6,SIS
HKD2_k127_8963615_6	1321778.HMPREF1982_01276	1.548e-57	202.0	COG1376@1|root,COG1376@2|Bacteria,1V9XU@1239|Firmicutes,24NW6@186801|Clostridia	186801|Clostridia	M	ErfK YbiS YcfS YnhG family protein	-	-	-	-	-	-	-	-	-	-	-	-	YkuD
HKD2_k127_8964181_7	941824.TCEL_00161	1.401e-31	128.0	COG5011@1|root,COG5011@2|Bacteria,1V4D0@1239|Firmicutes,249GU@186801|Clostridia,36EY8@31979|Clostridiaceae	186801|Clostridia	S	Radical SAM-linked protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF2344
HKD2_k127_8964181_0	1195236.CTER_4627	7.935e-272	848.0	COG1032@1|root,COG1032@2|Bacteria,1TR2C@1239|Firmicutes,248HM@186801|Clostridia,3WHME@541000|Ruminococcaceae	186801|Clostridia	C	Radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
HKD2_k127_8964181_8	926561.KB900617_gene1822	2.312e-31	134.0	COG1994@1|root,COG1994@2|Bacteria,1V72P@1239|Firmicutes,24B9J@186801|Clostridia,3WAVT@53433|Halanaerobiales	186801|Clostridia	K	PFAM Peptidase family M50	-	-	-	ko:K06402	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	CBS,Peptidase_M50
HKD2_k127_8964181_6	697281.Mahau_1016	1.02e-34	143.0	COG0739@1|root,COG0739@2|Bacteria,1VAC5@1239|Firmicutes,25E3G@186801|Clostridia,42GZQ@68295|Thermoanaerobacterales	186801|Clostridia	M	Peptidase family M23	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
HKD2_k127_8964181_5	350688.Clos_1759	5.057e-35	136.0	COG0851@1|root,COG0851@2|Bacteria,1VFST@1239|Firmicutes,24QT6@186801|Clostridia,36MK5@31979|Clostridiaceae	186801|Clostridia	D	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell	minE	-	-	ko:K03608	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	MinE
HKD2_k127_8964181_2	509191.AEDB02000100_gene4106	2.457e-131	423.0	COG2894@1|root,COG2894@2|Bacteria,1TP6P@1239|Firmicutes,249BB@186801|Clostridia,3WH0T@541000|Ruminococcaceae	186801|Clostridia	D	Belongs to the ParA family	minD	-	-	ko:K03609	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31,CbiA
HKD2_k127_8964181_4	1304284.L21TH_2128	1.776e-48	181.0	COG0850@1|root,COG0850@2|Bacteria,1VAPC@1239|Firmicutes,24MV1@186801|Clostridia,36FSA@31979|Clostridiaceae	186801|Clostridia	D	Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization	minC	-	-	ko:K03610	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	MinC_C
HKD2_k127_8964181_1	2325.TKV_c09120	5.118e-152	510.0	COG0768@1|root,COG0768@2|Bacteria,1TQHY@1239|Firmicutes,2480Z@186801|Clostridia,42FN0@68295|Thermoanaerobacterales	186801|Clostridia	M	Penicillin-binding protein, dimerisation domain	mrdA	-	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	-	PBP_dimer,Transpeptidase
HKD2_k127_8964181_9	350688.Clos_1763	1.599e-21	100.0	COG2891@1|root,COG2891@2|Bacteria,1V1EJ@1239|Firmicutes,24GF4@186801|Clostridia	186801|Clostridia	M	rod shape-determining protein MreD	mreD	-	-	ko:K03571	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreD
HKD2_k127_8964181_3	340099.Teth39_1451	2.977e-54	201.0	COG1792@1|root,COG1792@2|Bacteria,1TR1V@1239|Firmicutes,249M3@186801|Clostridia,42GQR@68295|Thermoanaerobacterales	186801|Clostridia	M	Involved in formation and maintenance of cell shape	mreC	-	-	ko:K03570	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreC
HKD2_k127_8964181_10	457396.CSBG_02805	4.098e-05	46.0	COG1077@1|root,COG1077@2|Bacteria,1TP51@1239|Firmicutes,247RG@186801|Clostridia,36DUP@31979|Clostridiaceae	186801|Clostridia	D	Cell shape determining protein, MreB Mrl family	mreB	-	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
HKD2_k127_8964401_1	1321778.HMPREF1982_04095	1.958e-115	378.0	COG2008@1|root,COG2008@2|Bacteria,1TPZI@1239|Firmicutes	1239|Firmicutes	E	Threonine aldolase	ltaA	-	4.1.2.48	ko:K01620	ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230	-	R00751,R06171	RC00312,RC00372	ko00000,ko00001,ko01000	-	-	-	Beta_elim_lyase
HKD2_k127_8964401_0	1121335.Clst_2556	4.767e-193	620.0	COG0488@1|root,COG0488@2|Bacteria,1TPAX@1239|Firmicutes,247U6@186801|Clostridia,3WGHX@541000|Ruminococcaceae	186801|Clostridia	S	ABC transporter	-	-	-	ko:K06158	-	-	-	-	ko00000,ko03012	-	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
HKD2_k127_8965985_1	1347392.CCEZ01000019_gene1026	9.608e-53	191.0	COG1304@1|root,COG1304@2|Bacteria,1TQZ3@1239|Firmicutes,249PR@186801|Clostridia	186801|Clostridia	C	Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP)	fni	-	5.3.3.2	ko:K01823	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00095,M00096,M00364,M00365,M00366,M00367	R01123	RC00455	ko00000,ko00001,ko00002,ko01000	-	-	-	FMN_dh
HKD2_k127_8965985_4	1121428.DESHY_160021___1	7.91e-19	89.0	2FJGG@1|root,34B62@2|Bacteria,1VYQ0@1239|Firmicutes,254CW@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8965985_2	1157490.EL26_06000	5.328e-50	192.0	COG1657@1|root,COG1657@2|Bacteria	2|Bacteria	I	PFAM Prenyltransferase squalene oxidase	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,DUF1194,DUF4159,Methyltransf_23,Prenyltrans,SLH,SQHop_cyclase_C
HKD2_k127_8965985_3	398512.JQKC01000087_gene2560	1.24e-33	136.0	2EK21@1|root,33DSG@2|Bacteria,1VPBH@1239|Firmicutes	1239|Firmicutes	S	Protein of unknown function (DUF3221)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3221
HKD2_k127_8965985_0	1294142.CINTURNW_1538	3.206e-113	385.0	COG0642@1|root,COG2205@2|Bacteria,1TQMV@1239|Firmicutes,247SE@186801|Clostridia,36ERX@31979|Clostridiaceae	186801|Clostridia	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_9
HKD2_k127_8983930_3	1321778.HMPREF1982_01557	1.98e-96	320.0	2DTDV@1|root,33JXB@2|Bacteria,1UIPN@1239|Firmicutes,24WD8@186801|Clostridia	186801|Clostridia	S	FR47-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HKD2_k127_8983930_2	246194.CHY_1128	2.195e-169	551.0	COG0747@1|root,COG0747@2|Bacteria,1TQ6S@1239|Firmicutes,248A3@186801|Clostridia,42GBR@68295|Thermoanaerobacterales	186801|Clostridia	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
HKD2_k127_8983930_6	635013.TherJR_0796	2.551e-25	113.0	28NEN@1|root,2ZBH5@2|Bacteria,1VH0Z@1239|Firmicutes,24IXB@186801|Clostridia,265W6@186807|Peptococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8983930_5	1071073.KI530539_gene19	3.537e-64	238.0	COG0642@1|root,COG2205@2|Bacteria,1U59C@1239|Firmicutes,4ITWI@91061|Bacilli	91061|Bacilli	T	GHKL domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
HKD2_k127_8983930_4	635013.TherJR_0798	6.689e-65	229.0	COG0745@1|root,COG0745@2|Bacteria,1V13C@1239|Firmicutes,25GGZ@186801|Clostridia,261TM@186807|Peptococcaceae	186801|Clostridia	T	response regulator	-	-	-	ko:K11692	ko02020,map02020	M00489	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_IclR,Response_reg
HKD2_k127_8983930_1	525903.Taci_0120	8.709e-179	569.0	COG1879@1|root,COG1879@2|Bacteria,3TA8M@508458|Synergistetes	508458|Synergistetes	G	Protein of unknown function (DUF3798)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3798
HKD2_k127_8983930_0	525903.Taci_0121	2.113e-193	613.0	COG1129@1|root,COG1129@2|Bacteria,3TA0G@508458|Synergistetes	508458|Synergistetes	G	PFAM ABC transporter	-	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
HKD2_k127_8996503_5	1121324.CLIT_10c03170	2.029e-65	232.0	COG2843@1|root,COG2843@2|Bacteria,1V20N@1239|Firmicutes,24AI2@186801|Clostridia	186801|Clostridia	M	D-alanyl-D-alanine carboxypeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M15_4
HKD2_k127_8996503_2	1304284.L21TH_0721	1.238e-139	456.0	COG0312@1|root,COG0312@2|Bacteria,1V3G5@1239|Firmicutes,249ZM@186801|Clostridia,36DH9@31979|Clostridiaceae	186801|Clostridia	S	Putative modulator of DNA gyrase	-	-	-	ko:K03592	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
HKD2_k127_8996503_0	1304284.L21TH_0720	1.115e-201	637.0	COG0312@1|root,COG0312@2|Bacteria,1TSQC@1239|Firmicutes,248MD@186801|Clostridia,36F5C@31979|Clostridiaceae	186801|Clostridia	S	modulator of DNA gyrase	-	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
HKD2_k127_8996503_6	1304284.L21TH_2216	3.014e-63	235.0	COG2199@1|root,COG3706@2|Bacteria,1V2AM@1239|Firmicutes,25EYJ@186801|Clostridia,36USX@31979|Clostridiaceae	186801|Clostridia	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,GGDEF,HisKA_7TM,PAS_9
HKD2_k127_8996503_3	1410668.JNKC01000006_gene605	1.434e-101	346.0	COG0477@1|root,COG2814@2|Bacteria,1UM9R@1239|Firmicutes,2486D@186801|Clostridia,36IWQ@31979|Clostridiaceae	186801|Clostridia	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD2_k127_8996503_1	335541.Swol_0353	3.466e-140	468.0	COG0643@1|root,COG1406@1|root,COG4191@1|root,COG0643@2|Bacteria,COG1406@2|Bacteria,COG4191@2|Bacteria,1TRES@1239|Firmicutes,24CUR@186801|Clostridia	186801|Clostridia	T	Histidine kinase-like ATPases	-	-	2.7.13.3	ko:K03407	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	CheX,HATPase_c
HKD2_k127_8996503_4	945713.IALB_2955	2.501e-94	323.0	COG0006@1|root,COG0006@2|Bacteria	2|Bacteria	E	proline dipeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M24
HKD2_k127_9037997_5	457396.CSBG_02415	8.707e-17	82.0	COG2017@1|root,COG2017@2|Bacteria,1TQGJ@1239|Firmicutes,249DZ@186801|Clostridia,36F59@31979|Clostridiaceae	186801|Clostridia	G	Converts alpha-aldose to the beta-anomer	-	-	5.1.3.3	ko:K01785	ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130	M00632	R01602,R10619	RC00563	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldose_epim
HKD2_k127_9037997_3	1540257.JQMW01000011_gene1478	2.775e-37	149.0	COG5423@1|root,COG5423@2|Bacteria,1V8BX@1239|Firmicutes,24JN8@186801|Clostridia,36KEI@31979|Clostridiaceae	186801|Clostridia	S	Predicted metal-binding protein (DUF2284)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2284
HKD2_k127_9037997_1	293826.Amet_4714	8.089e-134	432.0	COG0697@1|root,COG0697@2|Bacteria,1TTAJ@1239|Firmicutes,24EE0@186801|Clostridia	186801|Clostridia	EG	EamA-like transporter family	-	-	-	ko:K15268	-	-	-	-	ko00000,ko02000	2.A.7.3.2	-	-	EamA
HKD2_k127_9037997_2	1128398.Curi_c23240	4.298e-78	263.0	COG1853@1|root,COG1853@2|Bacteria,1V41U@1239|Firmicutes,24HTA@186801|Clostridia,268RV@186813|unclassified Clostridiales	186801|Clostridia	S	Flavin reductase like domain	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
HKD2_k127_9037997_0	1273538.G159_18085	0.0	1232.0	COG0553@1|root,COG4715@1|root,COG0553@2|Bacteria,COG4715@2|Bacteria,1TPFZ@1239|Firmicutes,4HAIF@91061|Bacilli,26E2D@186818|Planococcaceae	91061|Bacilli	KL	COG0553 Superfamily II DNA RNA helicases, SNF2 family	snf	-	-	-	-	-	-	-	-	-	-	-	Helicase_C,SNF2_N,SNF2_assoc,SWIM
HKD2_k127_9037997_4	646529.Desaci_2460	1.393e-20	93.0	COG1607@1|root,COG1607@2|Bacteria,1V3S2@1239|Firmicutes,24JIT@186801|Clostridia,265WG@186807|Peptococcaceae	186801|Clostridia	I	PFAM thioesterase superfamily	yciA	-	-	-	-	-	-	-	-	-	-	-	4HBT
HKD2_k127_9068158_0	1321778.HMPREF1982_01720	4.124e-118	393.0	COG4552@1|root,COG4552@2|Bacteria,1UHGY@1239|Firmicutes,25Q87@186801|Clostridia,26801@186813|unclassified Clostridiales	186801|Clostridia	S	Sterol carrier protein domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_9,SCP2_2
HKD2_k127_9068158_2	663278.Ethha_2271	2.341e-53	201.0	COG0640@1|root,COG0640@2|Bacteria,1VIR8@1239|Firmicutes	1239|Firmicutes	K	transcriptional regulator, ArsR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
HKD2_k127_9068158_4	398767.Glov_1988	2.502e-46	183.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,42M0W@68525|delta/epsilon subdivisions,2WIK8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS_9
HKD2_k127_9068158_3	1499967.BAYZ01000077_gene874	2.524e-47	173.0	COG0745@1|root,COG0745@2|Bacteria	1499967.BAYZ01000077_gene874|-	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9068158_1	1288494.EBAPG3_16830	2.741e-91	325.0	COG2770@1|root,COG4251@1|root,COG2770@2|Bacteria,COG4251@2|Bacteria,1NSQ1@1224|Proteobacteria,2VJGY@28216|Betaproteobacteria,372VE@32003|Nitrosomonadales	28216|Betaproteobacteria	T	GHKL domain	-	-	-	-	-	-	-	-	-	-	-	-	CHASE3,HAMP,HATPase_c,HisKA,PAS,PAS_9,TarH
HKD2_k127_9069627_7	350688.Clos_2162	2.835e-68	234.0	COG2217@1|root,COG2217@2|Bacteria,1TQ07@1239|Firmicutes,248EH@186801|Clostridia,36DXT@31979|Clostridiaceae	186801|Clostridia	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	cadA	-	3.6.3.3,3.6.3.5	ko:K01534	-	-	-	-	ko00000,ko01000	3.A.3.6	-	-	E1-E2_ATPase,HMA,Hydrolase
HKD2_k127_9069627_10	293826.Amet_3251	2.873e-20	95.0	COG3086@1|root,COG3086@2|Bacteria,1VECS@1239|Firmicutes,25DMR@186801|Clostridia,36UD3@31979|Clostridiaceae	186801|Clostridia	T	Positive regulator of sigma(E), RseC/MucC	-	-	-	ko:K03803	-	-	-	-	ko00000,ko03021	-	-	-	RseC_MucC
HKD2_k127_9069627_8	509191.AEDB02000021_gene3107	1.904e-47	175.0	2E9ZM@1|root,318K1@2|Bacteria,1V7PV@1239|Firmicutes,24T4K@186801|Clostridia,3WJKZ@541000|Ruminococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF2680
HKD2_k127_9069627_5	768706.Desor_0435	9.798e-99	326.0	COG0745@1|root,COG0745@2|Bacteria,1TPZ0@1239|Firmicutes,249IC@186801|Clostridia,260FJ@186807|Peptococcaceae	186801|Clostridia	K	PFAM response regulator receiver	-	-	-	ko:K07775	ko02020,map02020	M00458	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
HKD2_k127_9069627_2	509191.AEDB02000021_gene3109	1.069e-153	499.0	COG5002@1|root,COG5002@2|Bacteria,1TQ1H@1239|Firmicutes,247VG@186801|Clostridia,3WGR7@541000|Ruminococcaceae	186801|Clostridia	T	His Kinase A (phosphoacceptor) domain	-	-	2.7.13.3	ko:K07651,ko:K07652	ko02020,map02020	M00458,M00459	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
HKD2_k127_9069627_14	720554.Clocl_3235	3.359e-05	47.0	COG0251@1|root,COG0251@2|Bacteria,1V6PV@1239|Firmicutes,24JCM@186801|Clostridia	186801|Clostridia	J	Endoribonuclease L-PSP	-	-	-	-	-	-	-	-	-	-	-	-	Ribonuc_L-PSP
HKD2_k127_9069627_3	1304284.L21TH_0178	2.791e-131	427.0	COG4974@1|root,COG4974@2|Bacteria,1TQRG@1239|Firmicutes,247QQ@186801|Clostridia,36EKH@31979|Clostridiaceae	186801|Clostridia	L	Belongs to the 'phage' integrase family	xerC	-	-	ko:K03733,ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
HKD2_k127_9069627_11	871968.DESME_07685	4.171e-13	72.0	2ESBA@1|root,33JW1@2|Bacteria,1VN1A@1239|Firmicutes,24W5F@186801|Clostridia,2636U@186807|Peptococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9069627_13	1118054.CAGW01000003_gene42	1.232e-06	54.0	COG1388@1|root,COG1388@2|Bacteria,1VK5T@1239|Firmicutes	1239|Firmicutes	M	Inhibits cell division during the SOS response. Affects a later stage of the cell division protein assembly, after the assembly of the Z ring, by probably suppressing recruitment of FtsL and or DivIC to the division machinery	yneA	GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496	-	-	-	-	-	-	-	-	-	-	LysM
HKD2_k127_9069627_6	635013.TherJR_1501	1.269e-85	290.0	COG1974@1|root,COG1974@2|Bacteria,1TQ3H@1239|Firmicutes,24AXJ@186801|Clostridia,2612Y@186807|Peptococcaceae	186801|Clostridia	K	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair	lexA	-	3.4.21.88	ko:K01356	-	M00729	-	-	ko00000,ko00002,ko01000,ko01002,ko03400	-	-	-	LexA_DNA_bind,Peptidase_S24
HKD2_k127_9069627_0	536227.CcarbDRAFT_0971	6.059e-247	779.0	COG0174@1|root,COG0174@2|Bacteria,1TNZA@1239|Firmicutes,2489S@186801|Clostridia,36DYK@31979|Clostridiaceae	186801|Clostridia	E	glutamine synthetase	glnA	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C
HKD2_k127_9069627_1	720554.Clocl_2019	1.953e-179	571.0	COG4100@1|root,COG4100@2|Bacteria,1TQ88@1239|Firmicutes,247Y4@186801|Clostridia,3WGF6@541000|Ruminococcaceae	186801|Clostridia	P	Cystathionine beta-lyase family protein involved in aluminum resistance	ynbB	-	-	-	-	-	-	-	-	-	-	-	Met_gamma_lyase
HKD2_k127_9069627_9	720554.Clocl_1745	8.355e-34	133.0	COG1923@1|root,COG1923@2|Bacteria,1VEGI@1239|Firmicutes,24QIM@186801|Clostridia,3WKJW@541000|Ruminococcaceae	186801|Clostridia	J	RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs	hfq	-	-	ko:K03666	ko02024,ko03018,ko05111,map02024,map03018,map05111	-	-	-	ko00000,ko00001,ko03019,ko03036	-	-	-	Hfq
HKD2_k127_9069627_4	857293.CAAU_0551	1.772e-113	374.0	COG0324@1|root,COG0324@2|Bacteria,1TPSC@1239|Firmicutes,248HB@186801|Clostridia,36DRA@31979|Clostridiaceae	186801|Clostridia	J	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)	miaA	-	2.5.1.75	ko:K00791	ko00908,ko01100,ko01110,map00908,map01100,map01110	-	R01122	RC02820	ko00000,ko00001,ko01000,ko01006,ko03016	-	-	-	IPPT
HKD2_k127_9069627_12	610130.Closa_2050	9.167e-10	59.0	COG0323@1|root,COG0323@2|Bacteria,1TPGK@1239|Firmicutes,24902@186801|Clostridia,21Z0R@1506553|Lachnoclostridium	186801|Clostridia	L	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex	mutL	-	-	ko:K03572	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	DNA_mis_repair,HATPase_c_3,MutL_C
HKD2_k127_9080101_2	1294142.CINTURNW_4241	2.467e-29	120.0	COG1942@1|root,COG1942@2|Bacteria,1VA6U@1239|Firmicutes,24MXT@186801|Clostridia,36KV1@31979|Clostridiaceae	186801|Clostridia	S	Domain of unknown function (DUF1904)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1904
HKD2_k127_9080101_0	697303.Thewi_0414	2.838e-143	459.0	COG0714@1|root,COG0714@2|Bacteria,1TPKR@1239|Firmicutes,248IM@186801|Clostridia,42FB4@68295|Thermoanaerobacterales	186801|Clostridia	S	PFAM ATPase associated with various cellular activities	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
HKD2_k127_9080101_1	580331.Thit_0325	7.02e-93	318.0	COG1721@1|root,COG1721@2|Bacteria,1TSYT@1239|Firmicutes,249GJ@186801|Clostridia,42GIH@68295|Thermoanaerobacterales	186801|Clostridia	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
HKD2_k127_9088274_1	1294142.CINTURNW_3271	2.117e-61	221.0	COG0778@1|root,COG0778@2|Bacteria,1VCIT@1239|Firmicutes,25CKS@186801|Clostridia,36WXU@31979|Clostridiaceae	186801|Clostridia	C	Putative TM nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	TM1586_NiRdase
HKD2_k127_9088274_3	1321778.HMPREF1982_00682	1.933e-27	117.0	COG1846@1|root,COG1846@2|Bacteria,1VQ9C@1239|Firmicutes	1239|Firmicutes	K	Winged helix DNA-binding domain	-	-	-	ko:K22296	-	-	-	-	ko00000,ko03000	-	-	-	MarR,MarR_2
HKD2_k127_9088274_2	318464.IO99_05685	1.389e-30	125.0	COG2846@1|root,COG2846@2|Bacteria,1VGYW@1239|Firmicutes,24RAK@186801|Clostridia,36NBW@31979|Clostridiaceae	186801|Clostridia	D	PFAM Hemerythrin HHE cation binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
HKD2_k127_9088274_0	509191.AEDB02000022_gene3080	1.394e-174	550.0	COG0369@1|root,COG1151@2|Bacteria,1TRSC@1239|Firmicutes,248HQ@186801|Clostridia,3WH69@541000|Ruminococcaceae	186801|Clostridia	C	TIGRFAM carbon-monoxide dehydrogenase, catalytic subunit	cooS	-	1.2.7.4	ko:K00198	ko00633,ko00680,ko00720,ko01120,ko01200,map00633,map00680,map00720,map01120,map01200	M00377	R07157,R08034	RC00250,RC02800	ko00000,ko00001,ko00002,ko01000	-	-	-	Prismane
HKD2_k127_9100690_0	509191.AEDB02000074_gene1744	1.619e-70	243.0	COG0697@1|root,COG0697@2|Bacteria,1TP7K@1239|Firmicutes,248Q8@186801|Clostridia,3WHDF@541000|Ruminococcaceae	186801|Clostridia	EG	spore germination protein	gerKA1	-	-	ko:K06295	-	-	-	-	ko00000	-	-	-	GerA
HKD2_k127_9100690_1	509191.AEDB02000074_gene1745	4.683e-67	243.0	2DBJR@1|root,2Z9N7@2|Bacteria,1TRSN@1239|Firmicutes,249AT@186801|Clostridia,3WKX8@541000|Ruminococcaceae	186801|Clostridia	S	Spore germination B3/ GerAC like, C-terminal	-	-	-	ko:K06297	-	-	-	-	ko00000	-	-	-	Spore_GerAC
HKD2_k127_9100690_2	324057.Pjdr2_2914	5.07e-10	70.0	COG0531@1|root,COG0531@2|Bacteria,1UM4D@1239|Firmicutes,4IT7U@91061|Bacilli,2779N@186822|Paenibacillaceae	1239|Firmicutes	E	TIGRFAM spore germination protein	-	-	-	ko:K06296	-	-	-	-	ko00000,ko02000	2.A.3.9.3	-	-	Spore_permease
HKD2_k127_9100868_1	1121335.Clst_1455	2.264e-81	272.0	COG1388@1|root,COG2866@1|root,COG3409@1|root,COG1388@2|Bacteria,COG2866@2|Bacteria,COG3409@2|Bacteria,1TP3K@1239|Firmicutes,249MT@186801|Clostridia,3WHJW@541000|Ruminococcaceae	186801|Clostridia	EM	Carboxypeptidase	-	-	3.4.19.11	ko:K01308	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	LysM,PG_binding_1,Peptidase_M14
HKD2_k127_9100868_3	1408422.JHYF01000002_gene2603	1.038e-37	151.0	2EDJ2@1|root,337EY@2|Bacteria,1VERQ@1239|Firmicutes,24M7K@186801|Clostridia,36K3K@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9100868_0	1408422.JHYF01000002_gene2602	1.11e-127	413.0	COG1131@1|root,COG1131@2|Bacteria,1TS5Y@1239|Firmicutes,24AH1@186801|Clostridia,36FUM@31979|Clostridiaceae	186801|Clostridia	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD2_k127_9100868_2	1408422.JHYF01000002_gene2601	1.58e-52	187.0	COG1725@1|root,COG1725@2|Bacteria,1VAC6@1239|Firmicutes,24MVE@186801|Clostridia,36KRS@31979|Clostridiaceae	186801|Clostridia	K	GntR family	-	-	-	-	-	-	-	-	-	-	-	-	GntR
HKD2_k127_9100868_4	1321778.HMPREF1982_00672	4.06e-22	95.0	COG1592@1|root,COG1592@2|Bacteria,1V1PW@1239|Firmicutes,25B8Q@186801|Clostridia	186801|Clostridia	C	PFAM Rubrerythrin	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
HKD2_k127_9108980_0	509191.AEDB02000016_gene25	1.609e-288	904.0	COG3973@1|root,COG3973@2|Bacteria,1TP39@1239|Firmicutes,249IG@186801|Clostridia,3WHDZ@541000|Ruminococcaceae	186801|Clostridia	L	Superfamily I DNA and RNA	-	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AAA_19,UvrD-helicase,UvrD_C,UvrD_C_2
HKD2_k127_9108980_2	1206777.B195_17319	1.867e-12	73.0	COG0454@1|root,COG0456@2|Bacteria,1RCTN@1224|Proteobacteria,1SRRN@1236|Gammaproteobacteria,1Z838@136849|Pseudomonas syringae group	1236|Gammaproteobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_10
HKD2_k127_9108980_1	1444309.JAQG01000157_gene3303	1.48e-82	280.0	COG1082@1|root,COG1082@2|Bacteria,1VCF0@1239|Firmicutes,4HTNJ@91061|Bacilli,27543@186822|Paenibacillaceae	91061|Bacilli	G	Xylose isomerase domain protein TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
HKD2_k127_9117219_4	931276.Cspa_c35070	1.204e-31	125.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,1TSSC@1239|Firmicutes,248I6@186801|Clostridia,36EW0@31979|Clostridiaceae	186801|Clostridia	C	pyruvate flavodoxin ferredoxin oxidoreductase domain protein	korA	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR,POR_N
HKD2_k127_9117219_2	293826.Amet_1212	1.865e-130	421.0	COG1013@1|root,COG1013@2|Bacteria,1TQJ2@1239|Firmicutes,25CAJ@186801|Clostridia,36WSB@31979|Clostridiaceae	186801|Clostridia	C	PFAM thiamine pyrophosphate protein domain protein TPP-binding	korB	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFO_beta_C,TPP_enzyme_C
HKD2_k127_9117219_3	1291050.JAGE01000001_gene2848	1.266e-111	369.0	COG4286@1|root,COG4286@2|Bacteria,1V2PW@1239|Firmicutes,248SR@186801|Clostridia,3WJFD@541000|Ruminococcaceae	186801|Clostridia	S	Uncharacterised protein family (UPF0160)	-	-	-	-	-	-	-	-	-	-	-	-	UPF0160
HKD2_k127_9117219_1	1487921.DP68_10470	2.977e-160	511.0	COG0010@1|root,COG0010@2|Bacteria,1TP2A@1239|Firmicutes,2493V@186801|Clostridia,36EJ8@31979|Clostridiaceae	186801|Clostridia	E	Catalyzes the conversion of N-formimidoyl-L-glutamate to L-glutamate and formamide	hutG	-	3.5.3.8	ko:K01479	ko00340,ko01100,map00340,map01100	M00045	R02285	RC00221,RC00681	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
HKD2_k127_9117219_0	755731.Clo1100_3206	3.269e-168	536.0	COG0550@1|root,COG0551@1|root,COG0550@2|Bacteria,COG0551@2|Bacteria,1TPJD@1239|Firmicutes,24810@186801|Clostridia,36DHG@31979|Clostridiaceae	186801|Clostridia	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topB	-	5.99.1.2	ko:K03169	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	Topoisom_bac,Toprim
HKD2_k127_9133308_0	1304284.L21TH_2172	4.052e-95	316.0	COG0174@1|root,COG0174@2|Bacteria,1TNZA@1239|Firmicutes,2489S@186801|Clostridia,36DYK@31979|Clostridiaceae	186801|Clostridia	E	glutamine synthetase	-	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
HKD2_k127_9133308_1	536232.CLM_3377	6.801e-49	187.0	COG1316@1|root,COG1316@2|Bacteria,1TR1B@1239|Firmicutes,24AAY@186801|Clostridia,36FHF@31979|Clostridiaceae	186801|Clostridia	K	cell envelope-related function transcriptional attenuator	lytR	-	-	-	-	-	-	-	-	-	-	-	LytR_C,LytR_cpsA_psr
HKD2_k127_9133308_2	272563.CD630_36660	2.202e-14	76.0	2DR4V@1|root,33A63@2|Bacteria,1VKGM@1239|Firmicutes,25NV6@186801|Clostridia,25RWC@186804|Peptostreptococcaceae	186801|Clostridia	S	Protein of unknown function (DUF3343)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3343
HKD2_k127_9135385_1	857293.CAAU_1470	8.143e-96	320.0	COG0322@1|root,COG0322@2|Bacteria,1TP4B@1239|Firmicutes,247TQ@186801|Clostridia,36DMH@31979|Clostridiaceae	186801|Clostridia	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	-	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N
HKD2_k127_9135385_3	1408422.JHYF01000003_gene882	9.194e-11	71.0	2ECVT@1|root,336T3@2|Bacteria,1VFU4@1239|Firmicutes,24S6H@186801|Clostridia,36NC8@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9135385_0	720554.Clocl_1676	1.863e-194	616.0	COG0771@1|root,COG0771@2|Bacteria,1TQ3P@1239|Firmicutes,248GS@186801|Clostridia,3WG85@541000|Ruminococcaceae	186801|Clostridia	M	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)	murD	-	6.3.2.9	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R02783	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	iHN637.CLJU_RS20420	Mur_ligase_C,Mur_ligase_M
HKD2_k127_9135385_2	1487921.DP68_17275	1.987e-66	230.0	COG0483@1|root,COG0483@2|Bacteria,1TR4E@1239|Firmicutes,24KJZ@186801|Clostridia,36JCB@31979|Clostridiaceae	186801|Clostridia	G	Inositol monophosphatase	-	-	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
HKD2_k127_9156066_2	398512.JQKC01000033_gene5004	5.864e-13	70.0	COG0566@1|root,COG0566@2|Bacteria,1V3JP@1239|Firmicutes,248DV@186801|Clostridia,3WIQ9@541000|Ruminococcaceae	186801|Clostridia	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family	spoU	-	-	ko:K03437	-	-	-	-	ko00000,ko03016	-	-	-	SpoU_methylase,SpoU_sub_bind
HKD2_k127_9156066_0	697281.Mahau_1066	1.451e-209	662.0	COG0606@1|root,COG0606@2|Bacteria,1TPPB@1239|Firmicutes,248T8@186801|Clostridia,42EQT@68295|Thermoanaerobacterales	186801|Clostridia	O	PFAM Magnesium chelatase, ChlI subunit	comM	-	-	ko:K07391	-	-	-	-	ko00000	-	-	-	ChlI,Mg_chelatase,Mg_chelatase_C
HKD2_k127_9156066_1	203119.Cthe_2680	3.208e-144	479.0	COG0457@1|root,COG0457@2|Bacteria,1V076@1239|Firmicutes,25B8Z@186801|Clostridia,3WM09@541000|Ruminococcaceae	186801|Clostridia	M	tail specific protease	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S41,TPR_1,TPR_2,TPR_8
HKD2_k127_9156066_3	509191.AEDB02000074_gene1750	1.162e-08	60.0	COG0758@1|root,COG0758@2|Bacteria,1TPP7@1239|Firmicutes,24AS2@186801|Clostridia,3WIM4@541000|Ruminococcaceae	186801|Clostridia	LU	DNA protecting protein DprA	dprA	-	-	ko:K04096	-	-	-	-	ko00000	-	-	-	DNA_processg_A
HKD2_k127_9162882_8	1121090.KB894685_gene3741	7.536e-15	74.0	COG0564@1|root,COG0564@2|Bacteria,1TPCM@1239|Firmicutes,4HBG2@91061|Bacilli,1ZC3M@1386|Bacillus	91061|Bacilli	J	Responsible for synthesis of pseudouridine from uracil	rluD	GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
HKD2_k127_9162882_6	1391646.AVSU01000054_gene1154	3.57e-66	229.0	COG2065@1|root,COG2065@2|Bacteria,1V3GV@1239|Firmicutes,24FQD@186801|Clostridia,25RCD@186804|Peptostreptococcaceae	186801|Clostridia	F	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant	pyrR	-	2.4.2.9	ko:K02825	ko00240,ko01100,map00240,map01100	-	R00966	RC00063	ko00000,ko00001,ko01000,ko03000	-	-	iHN637.CLJU_RS05275	Pribosyltran
HKD2_k127_9162882_1	1304880.JAGB01000001_gene578	4.215e-135	442.0	COG0044@1|root,COG0044@2|Bacteria,1TPQM@1239|Firmicutes,247V2@186801|Clostridia	186801|Clostridia	F	Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily	pyrC	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
HKD2_k127_9162882_3	1304284.L21TH_0654	9.799e-108	357.0	COG0284@1|root,COG0284@2|Bacteria,1TQ7P@1239|Firmicutes,247SZ@186801|Clostridia,36E3E@31979|Clostridiaceae	186801|Clostridia	F	Belongs to the OMP decarboxylase family. Type 2 subfamily	pyrF	-	4.1.1.23	ko:K01591	ko00240,ko01100,map00240,map01100	M00051	R00965	RC00409	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS17585	OMPdecase
HKD2_k127_9162882_5	720554.Clocl_2390	3.788e-70	245.0	COG0543@1|root,COG0543@2|Bacteria,1TQ5D@1239|Firmicutes,24AY2@186801|Clostridia,3WGW1@541000|Ruminococcaceae	186801|Clostridia	C	Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( )	pyrK	-	-	ko:K02823	ko00240,ko01100,map00240,map01100	-	-	-	ko00000,ko00001	-	-	-	DHODB_Fe-S_bind,FAD_binding_6,NAD_binding_1
HKD2_k127_9162882_2	398512.JQKC01000024_gene3189	1.908e-127	415.0	COG0167@1|root,COG0167@2|Bacteria,1TPFV@1239|Firmicutes,248CQ@186801|Clostridia,3WGC5@541000|Ruminococcaceae	186801|Clostridia	F	Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily	pyrD	-	1.3.1.14	ko:K17828	ko00240,ko01100,map00240,map01100	M00051	R01869	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
HKD2_k127_9162882_0	857293.CAAU_0947	2.018e-260	810.0	COG0733@1|root,COG0733@2|Bacteria,1TP6B@1239|Firmicutes,2485D@186801|Clostridia,36DFC@31979|Clostridiaceae	186801|Clostridia	S	Belongs to the sodium neurotransmitter symporter (SNF) (TC 2.A.22) family	-	-	-	ko:K03308	-	-	-	-	ko00000	2.A.22.4,2.A.22.5	-	-	SNF
HKD2_k127_9162882_7	857293.CAAU_0948	2.511e-44	169.0	29NU7@1|root,309SB@2|Bacteria,1V68J@1239|Firmicutes,24HMM@186801|Clostridia,36M13@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9162882_4	1304880.JAGB01000001_gene572	2.052e-88	299.0	COG1293@1|root,COG1293@2|Bacteria,1TQ8A@1239|Firmicutes,248RK@186801|Clostridia	186801|Clostridia	K	Fibronectin-binding protein	FbpA	-	-	-	-	-	-	-	-	-	-	-	DUF814,FbpA
HKD2_k127_9166119_13	592028.GCWU000321_01622	8.967e-60	213.0	COG1247@1|root,COG1247@2|Bacteria,1UMCM@1239|Firmicutes	1239|Firmicutes	M	-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9166119_2	1410653.JHVC01000001_gene1870	3.593e-176	557.0	COG1775@1|root,COG1775@2|Bacteria,1TSHM@1239|Firmicutes,249WE@186801|Clostridia,36EPN@31979|Clostridiaceae	186801|Clostridia	E	2-hydroxyglutaryl-CoA dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	HGD-D
HKD2_k127_9166119_3	1487921.DP68_16785	3.021e-138	441.0	COG1924@1|root,COG1924@2|Bacteria,1TQWR@1239|Firmicutes,2484G@186801|Clostridia,36DUS@31979|Clostridiaceae	186801|Clostridia	I	CoA-substrate-specific enzyme activase	fldI1	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG
HKD2_k127_9166119_11	1230342.CTM_10421	2.371e-74	251.0	COG0720@1|root,COG0720@2|Bacteria,1VAJX@1239|Firmicutes,24JS9@186801|Clostridia,36JJD@31979|Clostridiaceae	186801|Clostridia	H	synthase	queD	-	4.1.2.50,4.2.3.12	ko:K01737	ko00790,ko01100,map00790,map01100	M00842,M00843	R04286,R09959	RC01117,RC02846,RC02847	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	PTPS
HKD2_k127_9166119_6	536232.CLM_1796	6.95e-117	378.0	COG0602@1|root,COG0602@2|Bacteria,1TQ58@1239|Firmicutes,2499R@186801|Clostridia,36HKB@31979|Clostridiaceae	186801|Clostridia	H	Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds	queE	-	4.3.99.3	ko:K10026	ko00790,ko01100,map00790,map01100	-	R10002	RC02989	ko00000,ko00001,ko01000,ko03016	-	-	-	Fer4_12,Fer4_14,Radical_SAM
HKD2_k127_9166119_8	1487921.DP68_16770	1.134e-106	347.0	COG0302@1|root,COG0302@2|Bacteria,1TRNM@1239|Firmicutes,24867@186801|Clostridia,36DD1@31979|Clostridiaceae	186801|Clostridia	F	GTP cyclohydrolase	folE	-	3.5.4.16	ko:K01495	ko00790,ko01100,map00790,map01100	M00126,M00841,M00842,M00843	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	-	GTP_cyclohydroI
HKD2_k127_9166119_4	1410653.JHVC01000001_gene1865	2.786e-134	428.0	COG0603@1|root,COG0603@2|Bacteria,1TP4Z@1239|Firmicutes,2497A@186801|Clostridia,36DMD@31979|Clostridiaceae	186801|Clostridia	F	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))	queC	-	6.3.4.20	ko:K06920	ko00790,ko01100,map00790,map01100	-	R09978	RC00959	ko00000,ko00001,ko01000,ko03016	-	-	-	QueC
HKD2_k127_9166119_9	478749.BRYFOR_06113	1.683e-87	312.0	COG0515@1|root,COG4886@1|root,COG0515@2|Bacteria,COG4886@2|Bacteria,1V7U3@1239|Firmicutes	1239|Firmicutes	KLT	serine threonine protein kinase	pkn2	-	-	-	-	-	-	-	-	-	-	-	Pkinase
HKD2_k127_9166119_10	349161.Dred_2357	4.035e-82	312.0	COG5492@1|root,COG5492@2|Bacteria,1V17S@1239|Firmicutes,24GRG@186801|Clostridia	186801|Clostridia	N	S-layer domain-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,Big_5,Cadherin-like,SLH,Transglut_core
HKD2_k127_9166119_17	1121904.ARBP01000074_gene262	1.482e-17	99.0	COG4886@1|root,COG5492@1|root,COG4886@2|Bacteria,COG5492@2|Bacteria	2|Bacteria	N	domain, Protein	ligA1	-	-	-	-	-	-	-	-	-	-	-	Big_2
HKD2_k127_9166119_16	903814.ELI_0092	2.021e-20	109.0	COG5492@1|root,COG5492@2|Bacteria,1VBT6@1239|Firmicutes,25B2B@186801|Clostridia,25ZQX@186806|Eubacteriaceae	186801|Clostridia	N	Bacterial Ig-like domain 2	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,Flg_new
HKD2_k127_9166119_14	1122947.FR7_1196	3.46e-25	110.0	2CBD3@1|root,32RT4@2|Bacteria,1VCM9@1239|Firmicutes	1239|Firmicutes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9166119_0	913865.DOT_0168	1.396e-181	573.0	COG0287@1|root,COG0287@2|Bacteria,1UJAA@1239|Firmicutes,25EZ8@186801|Clostridia	186801|Clostridia	E	PFAM Ketopantoate reductase	-	-	1.1.1.169	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R02472	RC00726	ko00000,ko00001,ko00002,ko01000	-	-	-	ApbA
HKD2_k127_9166119_7	1195236.CTER_1481	5.308e-107	348.0	COG1309@1|root,COG1309@2|Bacteria,1V9RG@1239|Firmicutes,248Q6@186801|Clostridia	186801|Clostridia	K	Transcriptional regulator C-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_8,TetR_N
HKD2_k127_9166119_1	1541959.KQ51_00282	2.038e-179	594.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria	2|Bacteria	G	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)	ppsA	-	2.7.9.2,6.5.1.3	ko:K01007,ko:K14415	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	PEP-utilizers,PPDK_N
HKD2_k127_9166119_12	1321778.HMPREF1982_02909	5.726e-63	221.0	COG1309@1|root,COG1309@2|Bacteria,1VH8G@1239|Firmicutes,24SA7@186801|Clostridia	186801|Clostridia	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_8,TetR_N
HKD2_k127_9166119_5	1304866.K413DRAFT_3687	5.59e-122	404.0	COG0477@1|root,COG2814@2|Bacteria,1TRZB@1239|Firmicutes,24YGV@186801|Clostridia,36UY5@31979|Clostridiaceae	186801|Clostridia	EGP	Major facilitator superfamily	-	-	-	ko:K08217	-	-	-	-	br01600,ko00000,ko01504,ko02000	2.A.1.21.1,2.A.1.21.22	-	-	MFS_1,MFS_3
HKD2_k127_9195_1	1415775.U729_1851	1.255e-62	229.0	COG3705@1|root,COG3705@2|Bacteria,1TPZZ@1239|Firmicutes,248CB@186801|Clostridia,36DWG@31979|Clostridiaceae	186801|Clostridia	E	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine	hisZ	-	-	ko:K02502	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002	-	-	-	tRNA-synt_His
HKD2_k127_9195_2	903814.ELI_0362	3.575e-59	212.0	COG0040@1|root,COG0040@2|Bacteria,1TSVZ@1239|Firmicutes,249AR@186801|Clostridia,25VPN@186806|Eubacteriaceae	186801|Clostridia	F	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity	hisG	-	2.4.2.17	ko:K00765,ko:K02502	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002,ko01000	-	-	-	HisG
HKD2_k127_9195_0	1123075.AUDP01000011_gene1854	1.757e-89	305.0	COG0141@1|root,COG0141@2|Bacteria,1TPAW@1239|Firmicutes,248X8@186801|Clostridia,3WGCJ@541000|Ruminococcaceae	186801|Clostridia	E	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine	hisD	-	1.1.1.23	ko:K00013	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01158,R01163,R03012	RC00099,RC00242,RC00463	ko00000,ko00001,ko00002,ko01000	-	-	-	Histidinol_dh
HKD2_k127_9195471_2	1487921.DP68_04655	8.569e-55	193.0	COG0458@1|root,COG0458@2|Bacteria,1UIGF@1239|Firmicutes,25EMV@186801|Clostridia,36USI@31979|Clostridiaceae	186801|Clostridia	EF	ATP-grasp domain	-	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_3
HKD2_k127_9195471_0	1321778.HMPREF1982_01777	5.461e-227	709.0	COG4992@1|root,COG4992@2|Bacteria,1TP9S@1239|Firmicutes,248C9@186801|Clostridia,26803@186813|unclassified Clostridiales	186801|Clostridia	E	Psort location Cytoplasmic, score	argD	-	2.6.1.11,2.6.1.17,2.6.1.82	ko:K00821,ko:K09251	ko00220,ko00300,ko00330,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map00330,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R01155,R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
HKD2_k127_9195471_1	324057.Pjdr2_1611	8.955e-72	263.0	COG1387@1|root,COG4633@1|root,COG4733@1|root,COG5263@1|root,COG1387@2|Bacteria,COG4633@2|Bacteria,COG4733@2|Bacteria,COG5263@2|Bacteria,1UJ5H@1239|Firmicutes,4IT2G@91061|Bacilli,27785@186822|Paenibacillaceae	91061|Bacilli	E	S-layer homology domain	-	-	-	-	-	-	-	-	-	-	-	-	SLH,fn3
HKD2_k127_9215435_4	293826.Amet_4264	5.285e-11	63.0	COG2350@1|root,COG2350@2|Bacteria,1VJ1A@1239|Firmicutes,24WYY@186801|Clostridia	186801|Clostridia	S	YCII-related domain	-	-	-	ko:K09780	-	-	-	-	ko00000	-	-	-	YCII
HKD2_k127_9215435_3	1236973.JCM9157_3926	1.206e-20	101.0	COG0666@1|root,COG0666@2|Bacteria,1VH3E@1239|Firmicutes,4IRMK@91061|Bacilli	91061|Bacilli	S	response to abiotic stimulus	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9215435_2	931626.Awo_c33180	1.193e-87	298.0	COG1600@1|root,COG1600@2|Bacteria,1UFJF@1239|Firmicutes,24GR0@186801|Clostridia	186801|Clostridia	C	binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
HKD2_k127_9215435_1	192952.MM_3214	2.316e-94	320.0	arCOG02449@1|root,arCOG02449@2157|Archaea,2XZ1K@28890|Euryarchaeota,2NAXS@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
HKD2_k127_9215435_0	394503.Ccel_1662	3.695e-148	473.0	COG0738@1|root,COG0738@2|Bacteria,1TPB5@1239|Firmicutes,24913@186801|Clostridia,36GA9@31979|Clostridiaceae	186801|Clostridia	G	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD2_k127_9272833_2	865861.AZSU01000005_gene809	3.518e-33	130.0	COG1135@1|root,COG1135@2|Bacteria,1TPPN@1239|Firmicutes,248PZ@186801|Clostridia,36DVA@31979|Clostridiaceae	186801|Clostridia	P	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system	metN	-	-	ko:K02071	ko02010,map02010	M00238	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.24	-	-	ABC_tran,NIL
HKD2_k127_9272833_1	332101.JIBU02000079_gene3886	1.829e-59	210.0	COG2606@1|root,COG2606@2|Bacteria,1V3MU@1239|Firmicutes,24HH2@186801|Clostridia,36J03@31979|Clostridiaceae	186801|Clostridia	S	PFAM YbaK prolyl-tRNA synthetase associated region	EbsC	-	-	-	-	-	-	-	-	-	-	-	tRNA_edit
HKD2_k127_9272833_0	1237149.C900_03848	2.135e-96	342.0	COG0642@1|root,COG2205@2|Bacteria,4NDXU@976|Bacteroidetes,47JK3@768503|Cytophagia	976|Bacteroidetes	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Hpt,PAS_3,PAS_9,Response_reg
HKD2_k127_9272833_3	931276.Cspa_c54810	5.483e-07	56.0	28WRN@1|root,2ZIRC@2|Bacteria,1W2BV@1239|Firmicutes,24P3J@186801|Clostridia,36KGV@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9275793_3	1499689.CCNN01000007_gene1897	5.818e-198	625.0	COG0534@1|root,COG0534@2|Bacteria,1TNZN@1239|Firmicutes,247YX@186801|Clostridia,36DT9@31979|Clostridiaceae	186801|Clostridia	V	Mate efflux family protein	-	-	-	-	-	-	-	-	-	-	-	-	MatE
HKD2_k127_9275793_1	1120973.AQXL01000103_gene2514	1.461e-264	823.0	COG0405@1|root,COG0405@2|Bacteria,1TR9U@1239|Firmicutes,4HB23@91061|Bacilli,277X1@186823|Alicyclobacillaceae	91061|Bacilli	E	Gamma-glutamyltranspeptidase	ggt	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
HKD2_k127_9275793_8	1321778.HMPREF1982_02870	1.01e-83	284.0	COG2454@1|root,COG2454@2|Bacteria,1V42I@1239|Firmicutes,24BAF@186801|Clostridia	186801|Clostridia	S	Protein of unknown function (DUF434)	-	-	-	-	-	-	-	-	-	-	-	-	DUF434
HKD2_k127_9275793_4	1487921.DP68_07175	5.9e-156	498.0	COG3641@1|root,COG3641@2|Bacteria,1TS5F@1239|Firmicutes,247P0@186801|Clostridia,36DSV@31979|Clostridiaceae	186801|Clostridia	S	Phosphotransferase system, EIIC	-	-	-	ko:K07035	-	-	-	-	ko00000	-	-	-	PTS_EIIC_2
HKD2_k127_9275793_11	1384049.CD29_14030	1.318e-07	55.0	2EPHH@1|root,32FYJ@2|Bacteria,1U00W@1239|Firmicutes,4IBI1@91061|Bacilli,3IZVS@400634|Lysinibacillus	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9275793_6	1321778.HMPREF1982_01583	5.769e-94	316.0	COG0778@1|root,COG0778@2|Bacteria,1V0NJ@1239|Firmicutes,24FM7@186801|Clostridia,26AZ8@186813|unclassified Clostridiales	186801|Clostridia	C	Putative TM nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	TM1586_NiRdase
HKD2_k127_9275793_2	720554.Clocl_1039	6.836e-202	638.0	COG0534@1|root,COG0534@2|Bacteria,1TQMT@1239|Firmicutes,249WJ@186801|Clostridia,3WIF4@541000|Ruminococcaceae	186801|Clostridia	V	MATE efflux family protein	-	-	-	-	-	-	-	-	-	-	-	-	MatE
HKD2_k127_9275793_5	1122915.AUGY01000031_gene7583	4.382e-96	323.0	COG0583@1|root,COG0583@2|Bacteria,1TST3@1239|Firmicutes,4HDBC@91061|Bacilli,26TJF@186822|Paenibacillaceae	91061|Bacilli	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HKD2_k127_9275793_0	1321778.HMPREF1982_03067	2.637e-287	893.0	COG0488@1|root,COG0488@2|Bacteria,1TPAX@1239|Firmicutes,247Q9@186801|Clostridia,26856@186813|unclassified Clostridiales	186801|Clostridia	S	ABC transporter C-terminal domain	yfmR	-	-	ko:K15738	-	-	-	-	ko00000,ko02000	3.A.1.120.6	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
HKD2_k127_9275793_9	768706.Desor_2654	1.264e-45	169.0	2AXEX@1|root,31PEA@2|Bacteria,1V8IU@1239|Firmicutes,24KMI@186801|Clostridia,265N2@186807|Peptococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9275793_10	645991.Sgly_2004	6.69e-33	133.0	2F975@1|root,341IJ@2|Bacteria,1VXC1@1239|Firmicutes,251I9@186801|Clostridia,265IJ@186807|Peptococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9275793_7	1211817.CCAT010000045_gene3014	1.721e-89	298.0	COG0008@1|root,COG0008@2|Bacteria,1TP8G@1239|Firmicutes,247Y0@186801|Clostridia,36ENJ@31979|Clostridiaceae	186801|Clostridia	J	Glutaminyl-tRNA synthetase	glnS	-	6.1.1.18	ko:K01886	ko00970,ko01100,map00970,map01100	M00359,M00360	R03652	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1c,tRNA-synt_1c_C
HKD2_k127_9281696_16	641107.CDLVIII_3367	7.188e-10	60.0	COG4895@1|root,COG4895@2|Bacteria,1VEG3@1239|Firmicutes,24QNU@186801|Clostridia,36MN1@31979|Clostridiaceae	186801|Clostridia	S	Uncharacterized conserved protein (DUF2196)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2196
HKD2_k127_9281696_14	350688.Clos_1685	4.262e-39	149.0	COG3860@1|root,COG3860@2|Bacteria,1VH55@1239|Firmicutes,24SY9@186801|Clostridia,36KMH@31979|Clostridiaceae	186801|Clostridia	S	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9281696_15	1163671.JAGI01000003_gene766	1.89e-26	111.0	COG3860@1|root,COG3860@2|Bacteria,1VICJ@1239|Firmicutes,24RGR@186801|Clostridia,36MQ0@31979|Clostridiaceae	186801|Clostridia	S	Uncharacterized protein conserved in bacteria (DUF2087)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2087
HKD2_k127_9281696_8	485916.Dtox_2165	7.495e-95	312.0	28NIH@1|root,2ZBJX@2|Bacteria,1V1SN@1239|Firmicutes,24DH3@186801|Clostridia,261JZ@186807|Peptococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9281696_13	1123252.ATZF01000002_gene2264	4.533e-65	230.0	COG0789@1|root,COG0789@2|Bacteria,1UWWA@1239|Firmicutes,4I2ZM@91061|Bacilli,27CWP@186824|Thermoactinomycetaceae	91061|Bacilli	K	helix_turn_helix, mercury resistance	-	-	-	-	-	-	-	-	-	-	-	-	MerR_1,TipAS
HKD2_k127_9281696_0	1321778.HMPREF1982_02792	0.0	1019.0	COG0577@1|root,COG0577@2|Bacteria,1TPHU@1239|Firmicutes,247QW@186801|Clostridia,26CG4@186813|unclassified Clostridiales	186801|Clostridia	V	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX
HKD2_k127_9281696_12	1392493.JIAB01000001_gene1498	2.42e-73	254.0	COG1136@1|root,COG1136@2|Bacteria,1TQC9@1239|Firmicutes,248Z6@186801|Clostridia,27IBR@186928|unclassified Lachnospiraceae	186801|Clostridia	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD2_k127_9281696_9	1321778.HMPREF1982_02794	3.515e-94	312.0	COG1309@1|root,COG1309@2|Bacteria,1V8M2@1239|Firmicutes,24J7T@186801|Clostridia	186801|Clostridia	K	tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
HKD2_k127_9281696_7	871963.Desdi_1444	1.141e-113	371.0	COG1277@1|root,COG1277@2|Bacteria,1V787@1239|Firmicutes,25DDT@186801|Clostridia	186801|Clostridia	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_4
HKD2_k127_9281696_4	871963.Desdi_1443	5.123e-134	433.0	COG1131@1|root,COG1131@2|Bacteria,1TPBQ@1239|Firmicutes,247M8@186801|Clostridia,2643T@186807|Peptococcaceae	186801|Clostridia	V	ABC-type multidrug transport system ATPase component	-	-	-	ko:K01990,ko:K19309	ko02010,map02010	M00254,M00747	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.131.1	-	-	ABC_tran
HKD2_k127_9281696_11	871963.Desdi_1442	1.393e-76	261.0	COG1309@1|root,COG1309@2|Bacteria,1V2EH@1239|Firmicutes,24H5Z@186801|Clostridia,266R8@186807|Peptococcaceae	186801|Clostridia	K	PFAM Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
HKD2_k127_9281696_1	290402.Cbei_2779	3.882e-248	772.0	COG0513@1|root,COG0513@2|Bacteria,1TPAP@1239|Firmicutes,247IT@186801|Clostridia,36EGF@31979|Clostridiaceae	186801|Clostridia	L	DEAD-box RNA helicase involved in the assembly of the 50S ribosomal subunit. Has an RNA-dependent ATPase activity, which is specific for 23S rRNA, and a 3' to 5' RNA helicase activity that uses the energy of ATP hydrolysis to destabilize and unwind short rRNA duplexes	dbpA	-	3.6.4.13	ko:K05592	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019	-	-	-	DEAD,DbpA,Helicase_C
HKD2_k127_9281696_5	293826.Amet_3307	5.126e-124	400.0	COG0745@1|root,COG0745@2|Bacteria,1UDAQ@1239|Firmicutes,249RQ@186801|Clostridia,36FG9@31979|Clostridiaceae	186801|Clostridia	KT	transcriptional regulatory protein	kdpE	-	-	ko:K07667	ko02020,ko02024,map02020,map02024	M00454	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
HKD2_k127_9281696_2	293826.Amet_3308	3.293e-211	666.0	COG0642@1|root,COG2205@2|Bacteria,1TQHB@1239|Firmicutes,247S4@186801|Clostridia,36DXC@31979|Clostridiaceae	186801|Clostridia	T	Histidine kinase	kdpD	-	2.7.13.3	ko:K07646	ko02020,map02020	M00454	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	DUF4118,HATPase_c,HisKA,KdpD,Usp
HKD2_k127_9281696_6	350688.Clos_0859	3.222e-115	374.0	COG0569@1|root,COG0569@2|Bacteria,1TQ9H@1239|Firmicutes,249C2@186801|Clostridia,36DGN@31979|Clostridiaceae	186801|Clostridia	P	Potassium uptake protein	ktrA	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
HKD2_k127_9281696_3	350688.Clos_0858	2.644e-208	655.0	COG0168@1|root,COG0168@2|Bacteria,1TQ4S@1239|Firmicutes,247Q3@186801|Clostridia,36DPR@31979|Clostridiaceae	186801|Clostridia	P	potassium uptake protein, TrkH family	-	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
HKD2_k127_9281696_10	398512.JQKC01000023_gene3341	1.094e-77	271.0	COG4188@1|root,COG4188@2|Bacteria,1V0PK@1239|Firmicutes,24C18@186801|Clostridia,3WIC6@541000|Ruminococcaceae	186801|Clostridia	S	Platelet-activating factor acetylhydrolase, isoform II	-	-	-	-	-	-	-	-	-	-	-	-	PAF-AH_p_II
HKD2_k127_9284456_1	1121324.CLIT_10c00910	1.623e-157	502.0	COG0372@1|root,COG0372@2|Bacteria,1TPPS@1239|Firmicutes,24865@186801|Clostridia,25SK5@186804|Peptostreptococcaceae	186801|Clostridia	C	Citrate synthase, C-terminal domain	gltA	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
HKD2_k127_9284456_2	1321778.HMPREF1982_00514	7.165e-141	451.0	COG1533@1|root,COG1533@2|Bacteria,1TSS2@1239|Firmicutes,248SB@186801|Clostridia,268M6@186813|unclassified Clostridiales	186801|Clostridia	L	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
HKD2_k127_9284456_5	1195236.CTER_2397	1.058e-103	340.0	COG1304@1|root,COG1304@2|Bacteria,1TUS7@1239|Firmicutes,248F9@186801|Clostridia,3WJ21@541000|Ruminococcaceae	186801|Clostridia	C	FMN binding	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9284456_0	484770.UFO1_0664	1.215e-192	604.0	COG0275@1|root,COG0275@2|Bacteria,1TP5R@1239|Firmicutes,4H3I3@909932|Negativicutes	909932|Negativicutes	M	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA	-	-	2.1.1.199	ko:K03438	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltransf_5
HKD2_k127_9284456_3	931626.Awo_c01650	4.666e-132	429.0	COG2110@1|root,COG2110@2|Bacteria,1TPCU@1239|Firmicutes,24ARG@186801|Clostridia,25UV0@186806|Eubacteriaceae	186801|Clostridia	S	phosphatase homologous to the C-terminal domain of histone macroH2A1	-	-	-	-	-	-	-	-	-	-	-	-	Macro
HKD2_k127_9284456_4	767817.Desgi_3508	4.714e-105	344.0	COG2304@1|root,COG2304@2|Bacteria,1TRPP@1239|Firmicutes,249HV@186801|Clostridia	186801|Clostridia	S	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	VWA
HKD2_k127_9284456_6	1304880.JAGB01000002_gene1687	1.104e-18	93.0	2DRGB@1|root,32UR1@2|Bacteria,1V72F@1239|Firmicutes,25DKW@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	ECF_trnsprt
HKD2_k127_9330361_8	272623.L0123	0.0005392	52.0	COG0745@1|root,COG0745@2|Bacteria,1TPWS@1239|Firmicutes,4H9KP@91061|Bacilli,1YBKJ@1357|Lactococcus	91061|Bacilli	K	Transcriptional regulatory protein, C terminal	phoP	-	-	ko:K07658	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
HKD2_k127_9330361_0	498761.HM1_1102	1.673e-182	584.0	COG0056@1|root,COG0056@2|Bacteria,1TNZ8@1239|Firmicutes,248IY@186801|Clostridia	186801|Clostridia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	atpA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
HKD2_k127_9330361_6	641149.HMPREF9016_01747	1.459e-08	62.0	COG0712@1|root,COG0712@2|Bacteria,1MVRH@1224|Proteobacteria,2VSJV@28216|Betaproteobacteria,2KRGX@206351|Neisseriales	206351|Neisseriales	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpH	-	-	ko:K02113	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	OSCP
HKD2_k127_9330361_7	382464.ABSI01000012_gene2276	5.342e-07	57.0	COG0711@1|root,COG0711@2|Bacteria,46SYI@74201|Verrucomicrobia,2IUEN@203494|Verrucomicrobiae	203494|Verrucomicrobiae	C	ATP synthase B/B' CF(0)	atpF	-	-	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_B
HKD2_k127_9330361_5	1128421.JAGA01000002_gene540	1.626e-23	101.0	COG0636@1|root,COG0636@2|Bacteria,2NQ21@2323|unclassified Bacteria	2|Bacteria	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpE	GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0042802,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02110,ko:K02124	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157,M00159	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1,3.A.2.2,3.A.2.3	-	-	ATP-synt_C
HKD2_k127_9330361_4	926550.CLDAP_05110	3.822e-38	154.0	COG0356@1|root,COG0356@2|Bacteria,2G6NF@200795|Chloroflexi	200795|Chloroflexi	C	it plays a direct role in the translocation of protons across the membrane	atpB	-	-	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1	-	-	ATP-synt_A
HKD2_k127_9330361_3	1347369.CCAD010000080_gene3110	1.858e-40	161.0	COG1477@1|root,COG1477@2|Bacteria,1TR9C@1239|Firmicutes,4HA6Y@91061|Bacilli,1ZECT@1386|Bacillus	91061|Bacilli	H	Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein	-	-	2.7.1.180	ko:K03734	-	-	-	-	ko00000,ko01000	-	-	-	ApbE
HKD2_k127_9330361_1	479434.Sthe_1355	6.15e-104	353.0	COG1109@1|root,COG1109@2|Bacteria,2G5YP@200795|Chloroflexi,27XV0@189775|Thermomicrobia	189775|Thermomicrobia	G	Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III	-	-	5.4.2.8	ko:K01840	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114	R01818	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
HKD2_k127_9330361_2	1280692.AUJL01000002_gene2653	1.552e-50	193.0	COG0836@1|root,COG0836@2|Bacteria,1TPC9@1239|Firmicutes,24908@186801|Clostridia,36DFS@31979|Clostridiaceae	186801|Clostridia	M	mannose-1-phosphate guanylyltransferase	manC	-	2.7.7.13	ko:K00971	ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110	M00114,M00361,M00362	R00885	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS00940	MannoseP_isomer,NTP_transferase
HKD2_k127_9351635_2	1163671.JAGI01000002_gene2338	4.461e-36	141.0	COG3290@1|root,COG3290@2|Bacteria,1TQJR@1239|Firmicutes,247YE@186801|Clostridia,36EQS@31979|Clostridiaceae	186801|Clostridia	T	signal transduction histidine kinase regulating citrate malate metabolism	citS	-	2.7.13.3	ko:K11614,ko:K11691	ko02020,map02020	M00489,M00490	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,PAS,PAS_8,PAS_9,SPOB_a,sCache_3_2
HKD2_k127_9351635_0	332101.JIBU02000005_gene404	1.197e-77	265.0	COG4565@1|root,COG4565@2|Bacteria,1V49R@1239|Firmicutes,24BJS@186801|Clostridia,36HG7@31979|Clostridiaceae	186801|Clostridia	KT	transcriptional regulatory protein	-	-	-	ko:K02475,ko:K11615,ko:K11692,ko:K11712	ko02020,map02020	M00489,M00490	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_11,HTH_IclR,Response_reg
HKD2_k127_9351635_1	1499689.CCNN01000013_gene3035	1.247e-42	160.0	COG1053@1|root,COG1053@2|Bacteria,1TPAR@1239|Firmicutes,247SY@186801|Clostridia,36UQE@31979|Clostridiaceae	186801|Clostridia	C	FAD dependent oxidoreductase	-	-	1.3.5.1,1.3.5.4	ko:K00239,ko:K00244	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,ko05134,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020,map05134	M00009,M00011,M00149,M00150,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,FMN_bind
HKD2_k127_9372622_1	1286171.EAL2_c20470	5.227e-61	214.0	COG3383@1|root,COG3383@2|Bacteria,1UI1F@1239|Firmicutes,25EAG@186801|Clostridia,25VUD@186806|Eubacteriaceae	186801|Clostridia	C	Molybdopterin oxidoreductase Fe4S4 domain	fdhA2	-	1.17.1.11,1.17.1.9	ko:K00123,ko:K22341	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Fer2_4,Fer4,Fer4_6,Fer4_7,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
HKD2_k127_9372622_0	1449126.JQKL01000020_gene3322	7.166e-157	499.0	COG1079@1|root,COG1079@2|Bacteria,1TP8Y@1239|Firmicutes,2486N@186801|Clostridia,26848@186813|unclassified Clostridiales	186801|Clostridia	S	Branched-chain amino acid transport system / permease component	tsgC13	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
HKD2_k127_9372622_2	1230342.CTM_25631	1.839e-17	83.0	COG4603@1|root,COG4603@2|Bacteria,1TP1F@1239|Firmicutes,2494C@186801|Clostridia,36EKF@31979|Clostridiaceae	186801|Clostridia	S	Belongs to the binding-protein-dependent transport system permease family	tsgB13	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
HKD2_k127_9413508_4	994573.T472_0200200	1.274e-28	119.0	COG3976@1|root,COG3976@2|Bacteria,1VFG0@1239|Firmicutes,24RHT@186801|Clostridia,36MVQ@31979|Clostridiaceae	186801|Clostridia	S	PFAM FMN-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	FMN_bind
HKD2_k127_9413508_2	666686.B1NLA3E_11880	9.968e-54	193.0	COG0716@1|root,COG0716@2|Bacteria,1VFBM@1239|Firmicutes,4HYKX@91061|Bacilli	91061|Bacilli	C	FMN binding	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9413508_3	1541960.KQ78_01718	1.183e-31	131.0	COG1309@1|root,COG1309@2|Bacteria	2|Bacteria	K	transcriptional regulator	grdR	-	-	-	-	-	-	-	-	-	-	-	TetR_N
HKD2_k127_9413508_0	1280692.AUJL01000008_gene2395	9.599e-121	392.0	COG1915@1|root,COG1915@2|Bacteria,1TT91@1239|Firmicutes,24A6C@186801|Clostridia,36GXY@31979|Clostridiaceae	186801|Clostridia	S	PFAM LOR SDH bifunctional enzyme conserved region	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9424200_1	86416.Clopa_0951	1.682e-134	433.0	COG3958@1|root,COG3958@2|Bacteria,1V0K5@1239|Firmicutes,24914@186801|Clostridia,36E9P@31979|Clostridiaceae	186801|Clostridia	G	Transketolase	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
HKD2_k127_9424200_3	871963.Desdi_1578	2.532e-62	217.0	COG1970@1|root,COG1970@2|Bacteria,1VA14@1239|Firmicutes,24JAB@186801|Clostridia,262X6@186807|Peptococcaceae	186801|Clostridia	M	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell	mscL	-	-	ko:K03282	-	-	-	-	ko00000,ko02000	1.A.22.1	-	-	MscL
HKD2_k127_9424200_2	86416.Clopa_0949	1.534e-128	421.0	COG1454@1|root,COG1454@2|Bacteria,1TPB4@1239|Firmicutes,247IQ@186801|Clostridia,36IM5@31979|Clostridiaceae	186801|Clostridia	C	Iron-containing alcohol dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Fe-ADH
HKD2_k127_9424200_0	857293.CAAU_0628	1.293e-232	724.0	COG0334@1|root,COG0334@2|Bacteria,1TP45@1239|Firmicutes,24960@186801|Clostridia,36EGU@31979|Clostridiaceae	186801|Clostridia	E	Belongs to the Glu Leu Phe Val dehydrogenases family	gdhA	-	1.4.1.3,1.4.1.4	ko:K00261,ko:K00262	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
HKD2_k127_9425845_9	555079.Toce_1272	3.133e-15	81.0	COG1300@1|root,COG1300@2|Bacteria,1V81P@1239|Firmicutes,24NU8@186801|Clostridia,42GCQ@68295|Thermoanaerobacterales	186801|Clostridia	S	stage ii sporulation protein m	spoIIM	-	-	ko:K06384	-	-	-	-	ko00000	-	-	-	SpoIIM
HKD2_k127_9425845_5	1121289.JHVL01000005_gene935	2.028e-106	352.0	COG4974@1|root,COG4974@2|Bacteria,1TQRG@1239|Firmicutes,247QQ@186801|Clostridia,36DJ0@31979|Clostridiaceae	186801|Clostridia	L	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules	xerC	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
HKD2_k127_9425845_1	941824.TCEL_00235	4.432e-173	551.0	COG1015@1|root,COG1015@2|Bacteria,1TP70@1239|Firmicutes,247WB@186801|Clostridia,36E24@31979|Clostridiaceae	186801|Clostridia	G	Phosphotransfer between the C1 and C5 carbon atoms of pentose	deoB	-	5.4.2.7	ko:K01839	ko00030,ko00230,map00030,map00230	-	R01057,R02749	RC00408	ko00000,ko00001,ko01000	-	-	-	Metalloenzyme
HKD2_k127_9425845_3	1301100.HG529268_gene607	3.235e-120	391.0	COG0005@1|root,COG0005@2|Bacteria,1TQ37@1239|Firmicutes,247KQ@186801|Clostridia,36E47@31979|Clostridiaceae	186801|Clostridia	F	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate	punA	-	2.4.2.1	ko:K03783	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R01561,R01863,R01969,R02147,R02294,R02295,R02297,R02484,R02557,R02748,R08368,R10244	RC00033,RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	PNP_UDP_1
HKD2_k127_9425845_6	350688.Clos_1590	1.647e-105	349.0	COG0005@1|root,COG0005@2|Bacteria,1TQ37@1239|Firmicutes,247KQ@186801|Clostridia,36E47@31979|Clostridiaceae	186801|Clostridia	F	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate	-	-	2.4.2.1	ko:K03783	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R01561,R01863,R01969,R02147,R02294,R02295,R02297,R02484,R02557,R02748,R08368,R10244	RC00033,RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	PNP_UDP_1
HKD2_k127_9425845_0	857293.CAAU_2330	2.075e-193	612.0	COG0213@1|root,COG0213@2|Bacteria,1TPCH@1239|Firmicutes,24848@186801|Clostridia,36DHU@31979|Clostridiaceae	186801|Clostridia	F	pyrimidine-nucleoside phosphorylase	pdp	-	2.4.2.2,2.4.2.4	ko:K00756,ko:K00758	ko00240,ko00983,ko01100,ko05219,map00240,map00983,map01100,map05219	-	R01570,R01876,R02296,R02484,R08222,R08230	RC00063	ko00000,ko00001,ko01000	-	-	iHN637.CLJU_RS08925	Glycos_trans_3N,Glycos_transf_3,PYNP_C
HKD2_k127_9425845_4	350688.Clos_1588	1.105e-110	370.0	COG1686@1|root,COG1686@2|Bacteria,1TQN0@1239|Firmicutes,249B3@186801|Clostridia,36FB8@31979|Clostridiaceae	186801|Clostridia	M	Belongs to the peptidase S11 family	dacF	-	3.4.16.4	ko:K07258	ko00550,ko01100,map00550,map01100	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	PBP5_C,Peptidase_S11
HKD2_k127_9425845_8	293826.Amet_2530	3.893e-53	194.0	COG1994@1|root,COG1994@2|Bacteria,1V6D4@1239|Firmicutes,24K0D@186801|Clostridia,36HB5@31979|Clostridiaceae	186801|Clostridia	S	peptidase	ywhC	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M50
HKD2_k127_9425845_2	697281.Mahau_1447	4.921e-150	480.0	COG0180@1|root,COG0180@2|Bacteria,1TPY7@1239|Firmicutes,248RC@186801|Clostridia,42EWC@68295|Thermoanaerobacterales	186801|Clostridia	J	PFAM aminoacyl-tRNA synthetase class Ib	trpS	-	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
HKD2_k127_9425845_7	1121289.JHVL01000005_gene928	1.873e-57	208.0	COG1354@1|root,COG1354@2|Bacteria,1TRW3@1239|Firmicutes,249VW@186801|Clostridia,36EKU@31979|Clostridiaceae	186801|Clostridia	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves	scpA	-	-	ko:K05896	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpA
HKD2_k127_9425845_10	1128398.Curi_c14110	2.261e-14	74.0	COG1386@1|root,COG1386@2|Bacteria,1V6HI@1239|Firmicutes,24JW7@186801|Clostridia,269DT@186813|unclassified Clostridiales	186801|Clostridia	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves	scpB	-	-	ko:K06024	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpB
HKD2_k127_9459291_1	1304284.L21TH_0686	8.517e-214	686.0	COG1674@1|root,COG1674@2|Bacteria,1TPJR@1239|Firmicutes,247KM@186801|Clostridia,36DDP@31979|Clostridiaceae	186801|Clostridia	D	Belongs to the FtsK SpoIIIE SftA family	ftsK	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
HKD2_k127_9459291_3	941824.TCEL_01879	2.192e-162	522.0	COG0621@1|root,COG0621@2|Bacteria,1TP2W@1239|Firmicutes,2487D@186801|Clostridia,36E1K@31979|Clostridiaceae	186801|Clostridia	J	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12	rimO	-	2.8.4.4	ko:K14441	-	-	R10652	RC00003,RC03217	ko00000,ko01000,ko03009	-	-	-	Radical_SAM,TRAM,UPF0004
HKD2_k127_9459291_6	1033739.CAEU01000005_gene989	1.402e-49	182.0	COG0558@1|root,COG0558@2|Bacteria,1V6PJ@1239|Firmicutes,4HCEX@91061|Bacilli,26DG0@186818|Planococcaceae	91061|Bacilli	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pgsA	GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0045017,GO:0046474,GO:0046486,GO:0071704,GO:0090407,GO:1901576	2.7.8.5	ko:K00995	ko00564,ko01100,map00564,map01100	-	R01801	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	iSB619.SA_RS06365	CDP-OH_P_transf
HKD2_k127_9459291_4	1321778.HMPREF1982_02587	8.599e-138	450.0	COG1058@1|root,COG1546@1|root,COG1058@2|Bacteria,COG1546@2|Bacteria,1TQ1N@1239|Firmicutes,249WC@186801|Clostridia,267XB@186813|unclassified Clostridiales	186801|Clostridia	S	Belongs to the CinA family	cinA	-	3.5.1.42	ko:K03742,ko:K03743	ko00760,map00760	-	R02322	RC00100	ko00000,ko00001,ko01000	-	-	-	CinA,MoCF_biosynth
HKD2_k127_9459291_2	941824.TCEL_01881	1.041e-168	535.0	COG0468@1|root,COG0468@2|Bacteria,1TPD5@1239|Firmicutes,247SF@186801|Clostridia,36DUE@31979|Clostridiaceae	186801|Clostridia	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage	recA	-	-	ko:K03553	ko03440,map03440	M00729	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	RecA
HKD2_k127_9459291_7	1035196.HMPREF9998_00790	8.203e-26	115.0	COG2137@1|root,COG2137@2|Bacteria,1V72V@1239|Firmicutes,24KZH@186801|Clostridia,25RI7@186804|Peptostreptococcaceae	186801|Clostridia	S	Modulates RecA activity	recX	-	-	ko:K03565	-	-	-	-	ko00000,ko03400	-	-	-	RecX
HKD2_k127_9459291_0	941824.TCEL_01887	3.573e-236	739.0	COG1418@1|root,COG1418@2|Bacteria,1TP48@1239|Firmicutes,248G8@186801|Clostridia,36DXD@31979|Clostridiaceae	186801|Clostridia	S	Endoribonuclease that initiates mRNA decay	rny	-	-	ko:K18682	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DUF3552,HD,KH_1
HKD2_k127_9459291_5	315750.BPUM_1600	2.596e-94	316.0	COG1692@1|root,COG1692@2|Bacteria,1TR9P@1239|Firmicutes,4HAV5@91061|Bacilli,1ZC3D@1386|Bacillus	91061|Bacilli	S	protein conserved in bacteria	ymdB	GO:0003674,GO:0003824,GO:0004112,GO:0004113,GO:0008081,GO:0016787,GO:0016788,GO:0042578	-	ko:K02029,ko:K02030,ko:K09769	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	YmdB
HKD2_k127_9459291_8	1294265.JCM21738_402	5.421e-15	75.0	COG2359@1|root,COG2359@2|Bacteria,1V6G8@1239|Firmicutes,4HIQV@91061|Bacilli,1ZH05@1386|Bacillus	91061|Bacilli	S	Stage V sporulation protein S	spoVS	-	-	ko:K06416	-	-	-	-	ko00000	-	-	-	SpoVS
HKD2_k127_9468439_13	545243.BAEV01000039_gene1465	6.864e-07	51.0	COG4992@1|root,COG4992@2|Bacteria,1TP9S@1239|Firmicutes,248C9@186801|Clostridia,36DPQ@31979|Clostridiaceae	186801|Clostridia	E	PFAM Aminotransferase class-III	argD	-	2.6.1.11,2.6.1.17	ko:K00821	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
HKD2_k127_9468439_2	332101.JIBU02000045_gene3282	1.782e-143	464.0	COG1473@1|root,COG1473@2|Bacteria,1VTY2@1239|Firmicutes,24B48@186801|Clostridia,36EWZ@31979|Clostridiaceae	186801|Clostridia	S	Peptidase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
HKD2_k127_9468439_0	1304880.JAGB01000001_gene498	0.0	1186.0	COG0542@1|root,COG0542@2|Bacteria,1TPMU@1239|Firmicutes,247TD@186801|Clostridia	186801|Clostridia	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpB	-	-	ko:K03695,ko:K03696	ko01100,ko04213,map01100,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
HKD2_k127_9468439_11	1304880.JAGB01000001_gene670	3.456e-23	99.0	2BX75@1|root,32YCI@2|Bacteria,1VEDY@1239|Firmicutes,24QPW@186801|Clostridia	186801|Clostridia	S	'small, acid-soluble spore protein	sasP	-	-	ko:K06421	-	-	-	-	ko00000	-	-	-	SASP
HKD2_k127_9468439_6	926692.AZYG01000007_gene1219	5.072e-61	226.0	COG0477@1|root,COG2814@2|Bacteria,1UZPE@1239|Firmicutes,2490R@186801|Clostridia,3WB54@53433|Halanaerobiales	186801|Clostridia	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_3
HKD2_k127_9468439_8	1540257.JQMW01000013_gene1303	2.732e-52	190.0	COG1670@1|root,COG1670@2|Bacteria,1V1G8@1239|Firmicutes,24G73@186801|Clostridia,36I5H@31979|Clostridiaceae	186801|Clostridia	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
HKD2_k127_9468439_9	2325.TKV_c01400	2.878e-48	178.0	COG1670@1|root,COG1670@2|Bacteria,1V1G8@1239|Firmicutes,24G73@186801|Clostridia,42G9C@68295|Thermoanaerobacterales	186801|Clostridia	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
HKD2_k127_9468439_10	1308866.J416_08002	2.52e-36	142.0	COG0454@1|root,COG0456@2|Bacteria,1VC1N@1239|Firmicutes,4HJT0@91061|Bacilli	91061|Bacilli	K	PFAM GCN5-related N-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10,Acetyltransf_7
HKD2_k127_9468439_12	1121324.CLIT_10c02000	1.199e-19	98.0	COG1813@1|root,COG1813@2|Bacteria,1V7HU@1239|Firmicutes,24BDX@186801|Clostridia	186801|Clostridia	K	PFAM helix-turn-helix domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_19,HTH_3,HTH_31
HKD2_k127_9468439_1	509191.AEDB02000065_gene620	1.862e-276	854.0	COG0423@1|root,COG0423@2|Bacteria,1TP94@1239|Firmicutes,248FB@186801|Clostridia,3WGTU@541000|Ruminococcaceae	186801|Clostridia	J	Catalyzes the attachment of glycine to tRNA(Gly)	glyQS	GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005488,GO:0005515,GO:0016874,GO:0016875,GO:0046983,GO:0140098,GO:0140101	6.1.1.14	ko:K01880	ko00970,map00970	M00359,M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	HGTP_anticodon,tRNA-synt_2b
HKD2_k127_9468439_3	865861.AZSU01000001_gene221	5.383e-111	368.0	COG1363@1|root,COG1363@2|Bacteria,1TQ86@1239|Firmicutes,25CDF@186801|Clostridia,36DEF@31979|Clostridiaceae	186801|Clostridia	G	PFAM peptidase M42 family protein	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M42
HKD2_k127_9468439_4	1216932.CM240_2978	3.266e-103	339.0	COG0461@1|root,COG0461@2|Bacteria,1TREW@1239|Firmicutes,248WM@186801|Clostridia,36ETX@31979|Clostridiaceae	186801|Clostridia	F	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)	pyrE	-	2.4.2.10	ko:K00762	ko00240,ko01100,map00240,map01100	M00051	R01870	RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran
HKD2_k127_9468439_7	1304284.L21TH_2224	3.545e-57	201.0	COG1781@1|root,COG1781@2|Bacteria,1V6U9@1239|Firmicutes,24JJU@186801|Clostridia,36JII@31979|Clostridiaceae	186801|Clostridia	F	aspartate carbamoyltransferase, regulatory	pyrI	-	-	ko:K00610	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002	-	-	-	PyrI,PyrI_C
HKD2_k127_9468439_5	1304284.L21TH_2225	4.422e-95	315.0	COG0540@1|root,COG0540@2|Bacteria,1TQ96@1239|Firmicutes,2496D@186801|Clostridia,36DT0@31979|Clostridiaceae	186801|Clostridia	F	Belongs to the ATCase OTCase family	pyrB	-	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N,PyrI_C
HKD2_k127_9504547_2	768710.DesyoDRAFT_0040	2.187e-88	300.0	2BCUG@1|root,33U09@2|Bacteria,1VUJI@1239|Firmicutes,250I8@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9504547_4	1195236.CTER_4140	1.391e-42	163.0	2EA57@1|root,334A4@2|Bacteria,1VHEA@1239|Firmicutes,24RNE@186801|Clostridia,3WQK0@541000|Ruminococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9504547_0	86416.Clopa_1136	2.83e-143	460.0	2BZ6P@1|root,2Z8AB@2|Bacteria,1TRT3@1239|Firmicutes,247PA@186801|Clostridia,36EGY@31979|Clostridiaceae	186801|Clostridia	S	Domain of unknown function (DUF2935)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2935
HKD2_k127_9504547_3	1295642.H839_06209	1.067e-45	179.0	COG0457@1|root,COG0457@2|Bacteria,1VGMJ@1239|Firmicutes,4HQSY@91061|Bacilli	91061|Bacilli	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_10,TPR_2,TPR_7
HKD2_k127_9504547_6	857293.CAAU_0673	7.991e-29	118.0	2E9SM@1|root,333YT@2|Bacteria,1UM0N@1239|Firmicutes,25G8M@186801|Clostridia,36Q3P@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9504547_8	588581.Cpap_2316	1.522e-14	76.0	COG1331@1|root,COG1331@2|Bacteria,1TPRD@1239|Firmicutes,248PD@186801|Clostridia,3WHE8@541000|Ruminococcaceae	186801|Clostridia	O	Protein of unknown function, DUF255	-	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	GlcNAc_2-epim,Thioredox_DsbH
HKD2_k127_9504547_5	1033734.CAET01000065_gene2198	3.771e-37	147.0	COG0672@1|root,COG0672@2|Bacteria	2|Bacteria	P	high-affinity ferrous iron transmembrane transporter activity	-	-	-	ko:K07243	-	-	-	-	ko00000,ko02000	2.A.108.1,2.A.108.2	-	-	DUF2318,FTR1
HKD2_k127_9504547_1	1195236.CTER_3072	4.674e-115	375.0	COG2119@1|root,COG2119@2|Bacteria,1UFX2@1239|Firmicutes,24DHF@186801|Clostridia,3WJB8@541000|Ruminococcaceae	186801|Clostridia	S	Uncharacterized protein family UPF0016	-	-	-	-	-	-	-	-	-	-	-	-	UPF0016
HKD2_k127_9504547_9	86416.Clopa_0536	0.0002582	46.0	2ERU8@1|root,33JDF@2|Bacteria,1VQS4@1239|Firmicutes,24UNN@186801|Clostridia,36P0M@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9504547_7	588581.Cpap_2316	5.004e-19	89.0	COG1331@1|root,COG1331@2|Bacteria,1TPRD@1239|Firmicutes,248PD@186801|Clostridia,3WHE8@541000|Ruminococcaceae	186801|Clostridia	O	Protein of unknown function, DUF255	-	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	GlcNAc_2-epim,Thioredox_DsbH
HKD2_k127_9573969_1	573061.Clocel_4047	1.004e-132	429.0	COG4992@1|root,COG4992@2|Bacteria,1TP9S@1239|Firmicutes,248C9@186801|Clostridia,36DPQ@31979|Clostridiaceae	186801|Clostridia	E	PFAM Aminotransferase class-III	argD	-	2.6.1.11,2.6.1.17	ko:K00821	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
HKD2_k127_9573969_3	1487921.DP68_18460	1.129e-106	353.0	COG0548@1|root,COG0548@2|Bacteria,1TP0N@1239|Firmicutes,2486J@186801|Clostridia,36FWU@31979|Clostridiaceae	186801|Clostridia	E	Belongs to the acetylglutamate kinase family. ArgB subfamily	argB	-	2.7.2.8	ko:K00930	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R02649	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase
HKD2_k127_9573969_0	1487921.DP68_18465	5.814e-159	507.0	COG0002@1|root,COG0002@2|Bacteria,1TPVI@1239|Firmicutes,247R3@186801|Clostridia,36E3S@31979|Clostridiaceae	186801|Clostridia	E	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde	argC	-	1.2.1.38	ko:K00145	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R03443	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
HKD2_k127_9573969_6	332101.JIBU02000031_gene3112	4.421e-64	224.0	COG1246@1|root,COG1246@2|Bacteria,1V34P@1239|Firmicutes,24JDM@186801|Clostridia,36KBX@31979|Clostridiaceae	186801|Clostridia	E	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HKD2_k127_9573969_7	1321778.HMPREF1982_02312	1.328e-47	173.0	COG1393@1|root,COG1393@2|Bacteria,1V6H8@1239|Firmicutes,24JH6@186801|Clostridia,2695U@186813|unclassified Clostridiales	186801|Clostridia	P	ArsC family	-	-	-	-	-	-	-	-	-	-	-	-	ArsC,Glutaredoxin
HKD2_k127_9573969_8	1460635.JCM19038_2038	6.486e-08	58.0	2CP03@1|root,32SI7@2|Bacteria,1VB01@1239|Firmicutes,4HMV9@91061|Bacilli	91061|Bacilli	S	Cupin	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HKD2_k127_9573969_5	1304284.L21TH_0344	1.127e-83	288.0	COG0564@1|root,COG0564@2|Bacteria,1TR1M@1239|Firmicutes,248W3@186801|Clostridia,36E8F@31979|Clostridiaceae	186801|Clostridia	J	Responsible for synthesis of pseudouridine from uracil	rluC	-	5.4.99.24	ko:K06179	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
HKD2_k127_9573969_2	398512.JQKC01000006_gene715	3.328e-119	394.0	COG0500@1|root,COG0500@2|Bacteria,1UHX5@1239|Firmicutes,25E63@186801|Clostridia,3WHXA@541000|Ruminococcaceae	186801|Clostridia	Q	Methyltransferase TRM13	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_32
HKD2_k127_9573969_4	349161.Dred_1308	4.156e-102	341.0	COG2006@1|root,COG2006@2|Bacteria,1TRQ9@1239|Firmicutes,248BF@186801|Clostridia,266YZ@186807|Peptococcaceae	186801|Clostridia	S	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362,Fer4
HKD2_k127_9603625_2	641107.CDLVIII_1997	1.061e-57	204.0	COG0680@1|root,COG0680@2|Bacteria,1VE76@1239|Firmicutes,24S2H@186801|Clostridia,36MUP@31979|Clostridiaceae	186801|Clostridia	C	hydrogenase maturation protease	-	-	-	ko:K03605	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	HycI
HKD2_k127_9603625_3	536232.CLM_1995	5.176e-33	132.0	COG4892@1|root,COG4892@2|Bacteria,1VEGK@1239|Firmicutes,24QJ4@186801|Clostridia,36MKT@31979|Clostridiaceae	186801|Clostridia	G	PFAM cytochrome	-	-	-	-	-	-	-	-	-	-	-	-	Cyt-b5
HKD2_k127_9603625_0	1499689.CCNN01000006_gene737	4.061e-245	779.0	COG0068@1|root,COG0068@2|Bacteria,1TQM7@1239|Firmicutes,2494A@186801|Clostridia,36EAU@31979|Clostridiaceae	186801|Clostridia	O	Belongs to the carbamoyltransferase HypF family	hypF	-	-	ko:K04656	-	-	-	-	ko00000	-	-	-	Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF
HKD2_k127_9603625_4	290402.Cbei_3008	4.675e-26	110.0	COG0298@1|root,COG0298@2|Bacteria,1VFE0@1239|Firmicutes,24UXU@186801|Clostridia,36NYN@31979|Clostridiaceae	186801|Clostridia	O	Hydrogenase assembly chaperone hypC hupF	hypC	-	-	ko:K04653	-	-	-	-	ko00000	-	-	-	HupF_HypC
HKD2_k127_9603625_1	290402.Cbei_3007	2.392e-83	280.0	COG0409@1|root,COG0409@2|Bacteria,1TPM7@1239|Firmicutes,248EX@186801|Clostridia,36FKI@31979|Clostridiaceae	186801|Clostridia	O	hydrogenase expression formation protein HypD	hypD	-	-	ko:K04654	-	-	-	-	ko00000	-	-	-	HypD
HKD2_k127_9738277_1	1304880.JAGB01000003_gene1306	7.582e-95	314.0	COG0215@1|root,COG0215@2|Bacteria,1TP9D@1239|Firmicutes,247KS@186801|Clostridia	186801|Clostridia	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	-	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e,tRNA-synt_1g
HKD2_k127_9738277_3	498761.HM1_1354	3.114e-66	229.0	COG0245@1|root,COG1211@1|root,COG0245@2|Bacteria,COG1211@2|Bacteria,1V3P0@1239|Firmicutes,24HCM@186801|Clostridia	186801|Clostridia	I	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP)	ispF	-	2.7.7.60,4.6.1.12	ko:K01770,ko:K12506	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633,R05637	RC00002,RC01440	ko00000,ko00001,ko00002,ko01000	-	-	-	IspD,YgbB
HKD2_k127_9738277_2	1094508.Tsac_0984	1.371e-68	240.0	COG1211@1|root,COG1211@2|Bacteria,1V3M7@1239|Firmicutes,248E6@186801|Clostridia,42G6V@68295|Thermoanaerobacterales	186801|Clostridia	I	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP)	ispD	-	2.7.7.60	ko:K00991	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS20335	IspD
HKD2_k127_9738277_0	350688.Clos_0461	2.647e-125	412.0	COG4956@1|root,COG4956@2|Bacteria,1TP0P@1239|Firmicutes,248F4@186801|Clostridia,36DKW@31979|Clostridiaceae	186801|Clostridia	S	PFAM PilT protein domain protein	yacL	-	-	-	-	-	-	-	-	-	-	-	PIN,PIN_4,TRAM
HKD2_k127_9738277_4	1121289.JHVL01000023_gene75	2.933e-53	192.0	COG1329@1|root,COG1329@2|Bacteria,1V40K@1239|Firmicutes,24HHP@186801|Clostridia,36HYR@31979|Clostridiaceae	186801|Clostridia	K	PFAM Transcription factor CarD	carD	-	-	ko:K07736	-	-	-	-	ko00000,ko03000	-	-	-	CarD_CdnL_TRCF
HKD2_k127_9757608_12	195103.CPF_0032	4.82e-47	182.0	2BW9D@1|root,32W1C@2|Bacteria,1VDVK@1239|Firmicutes,24990@186801|Clostridia,36FDU@31979|Clostridiaceae	186801|Clostridia	S	Domain of unknown function (DUF1887)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1887
HKD2_k127_9757608_13	1410653.JHVC01000012_gene2355	1.236e-35	139.0	2C860@1|root,32RKH@2|Bacteria,1VATE@1239|Firmicutes,24MQ7@186801|Clostridia,36M3Y@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9757608_7	1031288.AXAA01000025_gene549	6.856e-112	366.0	COG1028@1|root,COG1028@2|Bacteria,1TPIK@1239|Firmicutes,25073@186801|Clostridia,36DHT@31979|Clostridiaceae	186801|Clostridia	IQ	Enoyl-(Acyl carrier protein) reductase	baiA	-	1.1.1.100,1.1.1.159	ko:K00059,ko:K00076	ko00061,ko00121,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00121,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short,adh_short_C2
HKD2_k127_9757608_2	1033740.CAEW01000024_gene1477	2.399e-169	540.0	COG0183@1|root,COG0183@2|Bacteria,1TP07@1239|Firmicutes,4H9RJ@91061|Bacilli,26D7U@186818|Planococcaceae	91061|Bacilli	I	Belongs to the thiolase family	atoB	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
HKD2_k127_9757608_8	138119.DSY3635	2.056e-110	366.0	COG2267@1|root,COG2267@2|Bacteria,1TSC4@1239|Firmicutes,24DBP@186801|Clostridia	186801|Clostridia	I	hydrolases or acyltransferases (alpha beta hydrolase superfamily)	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
HKD2_k127_9757608_10	1408422.JHYF01000002_gene2625	1.365e-93	314.0	COG2267@1|root,COG2267@2|Bacteria,1V049@1239|Firmicutes,25F0M@186801|Clostridia,36UU9@31979|Clostridiaceae	186801|Clostridia	I	Ndr family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
HKD2_k127_9757608_1	1304284.L21TH_1621	1.098e-197	626.0	COG3829@1|root,COG3829@2|Bacteria,1TP0E@1239|Firmicutes,247MB@186801|Clostridia,36DY7@31979|Clostridiaceae	186801|Clostridia	KT	PFAM sigma-54 factor interaction domain-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,PAS,PAS_4,PAS_9,Sigma54_activat
HKD2_k127_9757608_5	1304284.L21TH_1626	1.125e-140	451.0	COG0559@1|root,COG0559@2|Bacteria,1TR24@1239|Firmicutes,2480A@186801|Clostridia,36DZ6@31979|Clostridiaceae	186801|Clostridia	U	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HKD2_k127_9757608_6	1304284.L21TH_1627	1.926e-122	401.0	COG4177@1|root,COG4177@2|Bacteria,1TPMZ@1239|Firmicutes,248WH@186801|Clostridia,36DQT@31979|Clostridiaceae	186801|Clostridia	U	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01998,ko:K11961	ko02010,ko02024,map02010,map02024	M00237,M00323	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4,3.A.1.4.4,3.A.1.4.5	-	-	BPD_transp_2
HKD2_k127_9757608_11	697303.Thewi_0627	3.36e-93	312.0	COG0411@1|root,COG0411@2|Bacteria,1TR0P@1239|Firmicutes,2490B@186801|Clostridia,42FCE@68295|Thermoanaerobacterales	186801|Clostridia	E	PFAM ABC transporter related	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
HKD2_k127_9757608_9	1304284.L21TH_1629	3.315e-100	332.0	COG0410@1|root,COG0410@2|Bacteria,1TPW4@1239|Firmicutes,247PN@186801|Clostridia,36DF9@31979|Clostridiaceae	186801|Clostridia	E	ABC transporter	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
HKD2_k127_9757608_4	1304284.L21TH_1630	1.087e-152	492.0	COG0683@1|root,COG0683@2|Bacteria,1TPQ2@1239|Firmicutes,248H1@186801|Clostridia,36DTA@31979|Clostridiaceae	186801|Clostridia	E	PFAM Extracellular ligand-binding receptor	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
HKD2_k127_9757608_3	1304284.L21TH_1632	1.281e-166	529.0	COG0332@1|root,COG0332@2|Bacteria,1TRHZ@1239|Firmicutes,24BGX@186801|Clostridia,36H3V@31979|Clostridiaceae	186801|Clostridia	I	3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal	-	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
HKD2_k127_9757608_0	1304284.L21TH_1633	9.007e-218	682.0	COG0427@1|root,COG0427@2|Bacteria,1TPHC@1239|Firmicutes,247V0@186801|Clostridia,36FHR@31979|Clostridiaceae	186801|Clostridia	C	acetyl-CoA hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	AcetylCoA_hyd_C,AcetylCoA_hydro
HKD2_k127_9757608_14	1347368.HG964407_gene6725	9.935e-13	80.0	COG0457@1|root,COG1396@1|root,COG0457@2|Bacteria,COG1396@2|Bacteria,1UYX5@1239|Firmicutes,4HF70@91061|Bacilli,1ZD6X@1386|Bacillus	91061|Bacilli	K	Helix-turn-helix domain	-	-	-	ko:K20342,ko:K20391	ko02024,map02024	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_19,HTH_3
HKD2_k127_9762657_1	1304284.L21TH_1475	9.063e-67	233.0	2A5VR@1|root,30UMK@2|Bacteria,1V55I@1239|Firmicutes,24IJC@186801|Clostridia,36INN@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9762657_0	720554.Clocl_1443	2.021e-115	380.0	COG0309@1|root,COG0309@2|Bacteria,1TQP4@1239|Firmicutes,24963@186801|Clostridia,3WIME@541000|Ruminococcaceae	186801|Clostridia	O	PFAM AIR synthase related protein	hypE	-	-	ko:K04655	-	-	-	-	ko00000	-	-	-	AIRS,AIRS_C
HKD2_k127_9762657_2	323850.Shew_3183	1.148e-05	53.0	2DT0W@1|root,33I7A@2|Bacteria,1NYBT@1224|Proteobacteria,1SQYA@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9787808_0	97139.C824_03951	2.534e-311	959.0	COG2936@1|root,COG2936@2|Bacteria,1TT0H@1239|Firmicutes,248PY@186801|Clostridia,36KCX@31979|Clostridiaceae	186801|Clostridia	S	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain	-	-	-	ko:K06978	-	-	-	-	ko00000	-	-	-	PepX_C,Peptidase_S15
HKD2_k127_9787808_1	97139.C824_03952	7.807e-41	159.0	COG1309@1|root,COG1309@2|Bacteria,1VVPP@1239|Firmicutes,24I44@186801|Clostridia	186801|Clostridia	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
HKD2_k127_9787808_2	1410616.JHXE01000002_gene908	1.032e-40	162.0	COG0477@1|root,COG2814@2|Bacteria,1TS1N@1239|Firmicutes,24C0C@186801|Clostridia	186801|Clostridia	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD2_k127_9829317_0	857293.CAAU_2161	7.529e-222	697.0	COG2986@1|root,COG2986@2|Bacteria,1TPCW@1239|Firmicutes,247XP@186801|Clostridia,36DCC@31979|Clostridiaceae	186801|Clostridia	E	Histidine ammonia-lyase	hutH	-	4.3.1.3	ko:K01745	ko00340,ko01100,map00340,map01100	M00045	R01168	RC00361	ko00000,ko00001,ko00002,ko01000	-	-	-	Lyase_aromatic
HKD2_k127_9829317_6	756499.Desde_0837	3.302e-20	98.0	2E41I@1|root,32YY5@2|Bacteria,1VVZK@1239|Firmicutes,250RQ@186801|Clostridia,265ER@186807|Peptococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9829317_3	608506.COB47_0936	1.208e-42	162.0	COG1514@1|root,COG1514@2|Bacteria,1VEU2@1239|Firmicutes,24MTR@186801|Clostridia,42H6P@68295|Thermoanaerobacterales	186801|Clostridia	J	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester	ligT	-	3.1.4.58	ko:K01975	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	LigT_PEase
HKD2_k127_9829317_7	1051501.AYTL01000027_gene1010	1.579e-11	68.0	2E5FN@1|root,3307C@2|Bacteria,1VH91@1239|Firmicutes,4HP9B@91061|Bacilli,1ZJ6Z@1386|Bacillus	91061|Bacilli	S	Belongs to the UPF0180 family	ykuS	-	-	-	-	-	-	-	-	-	-	-	UPF0180
HKD2_k127_9829317_2	697303.Thewi_0928	6.476e-51	192.0	COG0739@1|root,COG0739@2|Bacteria,1V3ZU@1239|Firmicutes,24JM4@186801|Clostridia,42FFZ@68295|Thermoanaerobacterales	186801|Clostridia	M	Peptidase, M23	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
HKD2_k127_9829317_5	580331.Thit_0787	1.936e-32	130.0	COG1664@1|root,COG1664@2|Bacteria,1VEVU@1239|Firmicutes,24QT5@186801|Clostridia,42GQS@68295|Thermoanaerobacterales	186801|Clostridia	M	Polymer-forming cytoskeletal	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
HKD2_k127_9829317_4	1408422.JHYF01000017_gene1837	1.592e-34	134.0	2E34K@1|root,32Y4P@2|Bacteria,1VEWQ@1239|Firmicutes,24QJP@186801|Clostridia,36N03@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9829317_1	1408422.JHYF01000017_gene1838	3.526e-186	589.0	COG0389@1|root,COG0389@2|Bacteria,1TP42@1239|Firmicutes,24855@186801|Clostridia,36E0M@31979|Clostridiaceae	186801|Clostridia	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	dinB	-	2.7.7.7	ko:K02346	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C,IMS_HHH
HKD2_k127_9829317_8	203119.Cthe_2506	7.305e-08	55.0	COG1657@1|root,COG2911@1|root,COG3266@1|root,COG3533@1|root,COG1657@2|Bacteria,COG2911@2|Bacteria,COG3266@2|Bacteria,COG3533@2|Bacteria,1UIUN@1239|Firmicutes,25ESG@186801|Clostridia,3WNZG@541000|Ruminococcaceae	186801|Clostridia	G	Concanavalin A-like lectin/glucanases superfamily	-	-	-	-	-	-	-	-	-	-	-	-	CBM_3,Laminin_G_3
HKD2_k127_9870373_1	748727.CLJU_c18680	1.655e-110	358.0	COG3547@1|root,COG3547@2|Bacteria,1V1QJ@1239|Firmicutes,24ATE@186801|Clostridia,36E1N@31979|Clostridiaceae	186801|Clostridia	L	Transposase (IS116 IS110 IS902 family)	-	-	-	ko:K03599	-	-	-	-	ko00000,ko02000,ko03021	1.A.12.3.1	-	-	-
HKD2_k127_9870373_3	1321778.HMPREF1982_01413	8.339e-108	353.0	COG5523@1|root,COG5523@2|Bacteria,1V6FC@1239|Firmicutes,24JPX@186801|Clostridia,26B19@186813|unclassified Clostridiales	186801|Clostridia	S	Protein of unknown function (DUF975)	-	-	-	-	-	-	-	-	-	-	-	-	DUF975
HKD2_k127_9870373_4	1449050.JNLE01000003_gene2424	2.668e-56	208.0	COG2378@1|root,COG2378@2|Bacteria,1UXQS@1239|Firmicutes,24MHE@186801|Clostridia,36JSI@31979|Clostridiaceae	186801|Clostridia	K	WYL domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_11,WYL
HKD2_k127_9870373_2	1196322.A370_01578	8.744e-109	359.0	COG2404@1|root,COG2404@2|Bacteria,1UFBQ@1239|Firmicutes,24C28@186801|Clostridia	186801|Clostridia	S	hydrolase activity, acting on ester bonds	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9870373_0	1321778.HMPREF1982_01548	1.277e-110	362.0	COG0561@1|root,COG0561@2|Bacteria,1V8XN@1239|Firmicutes,24HQW@186801|Clostridia	186801|Clostridia	S	Sucrose-6F-phosphate phosphohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_3
HKD2_k127_9870373_5	1321778.HMPREF1982_00871	3.871e-25	105.0	COG2972@1|root,COG2972@2|Bacteria,1TPVR@1239|Firmicutes,247XB@186801|Clostridia,267NN@186813|unclassified Clostridiales	186801|Clostridia	T	Histidine kinase	-	-	2.7.13.3	ko:K07718	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,His_kinase,dCache_1
HKD2_k127_9968299_2	913865.DOT_2660	7.986e-32	135.0	2ECRX@1|root,336PJ@2|Bacteria,1VJAC@1239|Firmicutes,24RBA@186801|Clostridia,265Y4@186807|Peptococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9968299_0	332101.JIBU02000012_gene1049	2.169e-158	517.0	COG1835@1|root,COG1835@2|Bacteria,1V0J2@1239|Firmicutes,247YD@186801|Clostridia,36EK5@31979|Clostridiaceae	186801|Clostridia	I	Domain of unknown function (DUF4153)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4153
HKD2_k127_9968299_1	1499680.CCFE01000031_gene3710	2.546e-62	217.0	COG0577@1|root,COG1511@1|root,COG4591@1|root,COG0577@2|Bacteria,COG1511@2|Bacteria,COG4591@2|Bacteria,1TPHU@1239|Firmicutes,4HA2C@91061|Bacilli,1ZDI6@1386|Bacillus	91061|Bacilli	V	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
## 3106 queries scanned
## Total time (seconds): 36.598939418792725
## Rate: 84.87 q/s