## Wed Oct 16 20:59:02 2024
## emapper-2.1.12
## /data/home/zkh/miniconda3/envs/eggnog-mapper/bin/emapper.py -i /data/home/zkh/binning/Potential_rubisco_autotrophic/HKD2_bin.80.fa -m mmseqs --itype genome -o HKD2_bin.80 --output_dir /data/home/zkh/meta_analysis/eggnog-mapper/all_bins_1385/HKD2_bin.80 --cpu 28
##
#query	seed_ortholog	evalue	score	eggNOG_OGs	max_annot_lvl	COG_category	Description	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	PFAMs
HKD2_k127_102922_5	296591.Bpro_4269	4.977e-141	449.0	COG0719@1|root,COG0719@2|Bacteria,1MVKY@1224|Proteobacteria,2VJMX@28216|Betaproteobacteria,4AB3Y@80864|Comamonadaceae	28216|Betaproteobacteria	O	FeS assembly protein SufB	sufB	-	-	ko:K09014	-	-	-	-	ko00000	-	-	-	UPF0051
HKD2_k127_102922_6	314345.SPV1_11026	4.029e-120	391.0	COG0396@1|root,COG0396@2|Bacteria,1MUGK@1224|Proteobacteria	1224|Proteobacteria	O	FeS assembly ATPase SufC	sufC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0016043,GO:0016226,GO:0022607,GO:0031163,GO:0044085,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051186,GO:0071840	-	ko:K09013	-	-	-	-	ko00000,ko02000	-	-	iECH74115_1262.ECH74115_2396,iECIAI1_1343.ECIAI1_1734,iECIAI39_1322.ECIAI39_1376,iECSP_1301.ECSP_2249,iECs_1301.ECs2389,iEcSMS35_1347.EcSMS35_1514,iG2583_1286.G2583_2077,iSFV_1184.SFV_1705,iSFxv_1172.SFxv_1919,iSSON_1240.SSON_1474,iS_1188.S1844,iZ_1308.Z2710	ABC_tran
HKD2_k127_102922_14	713587.THITH_07300	9.165e-72	262.0	COG0719@1|root,COG0719@2|Bacteria,1MVK0@1224|Proteobacteria,1RP2A@1236|Gammaproteobacteria,1WWK5@135613|Chromatiales	135613|Chromatiales	O	FeS assembly protein SufD	-	-	-	ko:K09015	-	-	-	-	ko00000	-	-	-	UPF0051
HKD2_k127_102922_2	1026882.MAMP_02611	5.161e-176	572.0	COG0520@1|root,COG0520@2|Bacteria,1MUPD@1224|Proteobacteria,1RNIY@1236|Gammaproteobacteria,45ZNF@72273|Thiotrichales	72273|Thiotrichales	E	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine	sufS	-	2.8.1.7,4.4.1.16	ko:K11717	ko00450,ko01100,map00450,map01100	-	R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000	-	-	-	Aminotran_5
HKD2_k127_102922_15	713587.THITH_12765	2.874e-54	202.0	COG0822@1|root,COG0822@2|Bacteria,1RD5K@1224|Proteobacteria,1S3P1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters	nifU	-	-	ko:K04488	-	-	-	-	ko00000	-	-	-	NifU_N
HKD2_k127_102922_12	1442599.JAAN01000033_gene1598	7.075e-76	258.0	COG2151@1|root,COG2151@2|Bacteria,1MZ9Y@1224|Proteobacteria,1S36X@1236|Gammaproteobacteria,1X3XG@135614|Xanthomonadales	135614|Xanthomonadales	S	FeS assembly SUF system protein SufT	-	-	-	-	-	-	-	-	-	-	-	-	FeS_assembly_P
HKD2_k127_102922_22	1469245.JFBG01000025_gene1555	9.088e-31	127.0	COG2146@1|root,COG2146@2|Bacteria,1N8PE@1224|Proteobacteria,1S6B0@1236|Gammaproteobacteria,1WYPJ@135613|Chromatiales	135613|Chromatiales	P	PFAM Rieske 2Fe-2S	-	-	-	ko:K05710	ko00360,ko01120,ko01220,map00360,map01120,map01220	M00545	R06782,R06783	RC00098	br01602,ko00000,ko00001,ko00002	-	-	-	Rieske
HKD2_k127_102922_21	1237149.C900_01127	1.202e-35	148.0	COG2062@1|root,COG2062@2|Bacteria,4NQFM@976|Bacteroidetes,47R7I@768503|Cytophagia	976|Bacteroidetes	T	PFAM Phosphoglycerate mutase	sixA	-	-	ko:K08296	-	-	-	-	ko00000,ko01000	-	-	-	His_Phos_1
HKD2_k127_102922_13	883126.HMPREF9710_02529	2.82e-72	251.0	COG1028@1|root,COG1028@2|Bacteria,1N8G3@1224|Proteobacteria,2VI05@28216|Betaproteobacteria	28216|Betaproteobacteria	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HKD2_k127_102922_3	1463825.JNXC01000011_gene302	2.086e-162	544.0	COG1760@1|root,COG1760@2|Bacteria,2GJPA@201174|Actinobacteria,4DY5U@85010|Pseudonocardiales	201174|Actinobacteria	E	Serine dehydratase beta chain	sdaA	GO:0003674,GO:0003824,GO:0003941,GO:0016829,GO:0016840,GO:0016841	4.3.1.17	ko:K01752	ko00260,ko00270,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00270,map01100,map01110,map01130,map01200,map01230	-	R00220,R00590	RC00331,RC02600	ko00000,ko00001,ko01000	-	-	-	SDH_alpha,SDH_beta
HKD2_k127_102922_1	743721.Psesu_0170	0.0	1184.0	COG0506@1|root,COG4230@1|root,COG0506@2|Bacteria,COG4230@2|Bacteria,1MV93@1224|Proteobacteria,1RN48@1236|Gammaproteobacteria,1X36U@135614|Xanthomonadales	135614|Xanthomonadales	CE	Oxidizes proline to glutamate for use as a carbon and nitrogen source	putA	-	1.2.1.88,1.5.5.2	ko:K13821	ko00250,ko00330,ko01100,ko01110,ko01130,map00250,map00330,map01100,map01110,map01130	-	R00245,R00707,R00708,R01253,R04444,R04445,R05051	RC00080,RC00083,RC00216,RC00242,RC00255	ko00000,ko00001,ko01000,ko03000	-	-	-	Aldedh,Pro_dh,Pro_dh-DNA_bdg
HKD2_k127_102922_18	1384054.N790_01750	4.673e-49	183.0	COG3137@1|root,COG3137@2|Bacteria,1MWI4@1224|Proteobacteria,1RN4J@1236|Gammaproteobacteria,1X57Z@135614|Xanthomonadales	135614|Xanthomonadales	M	salt-induced outer membrane protein	-	-	-	ko:K07283	-	-	-	-	ko00000	-	-	-	DUF481
HKD2_k127_102922_16	765912.Thimo_2345	7.182e-54	200.0	COG3118@1|root,COG3118@2|Bacteria,1MV0R@1224|Proteobacteria,1RMSQ@1236|Gammaproteobacteria,1WXMF@135613|Chromatiales	135613|Chromatiales	O	PFAM Thioredoxin	-	-	-	ko:K05838	-	-	-	-	ko00000,ko03110	-	-	-	TPR_19,TPR_20,Thioredoxin
HKD2_k127_102922_0	1335757.SPICUR_06720	0.0	1264.0	COG0587@1|root,COG0587@2|Bacteria,1MUE4@1224|Proteobacteria,1RQA8@1236|Gammaproteobacteria,1WW62@135613|Chromatiales	135613|Chromatiales	L	DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase	dnaE2	-	2.7.7.7	ko:K14162	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
HKD2_k127_102922_10	292415.Tbd_0829	3.915e-82	293.0	COG0389@1|root,COG0389@2|Bacteria,1MU5X@1224|Proteobacteria,2VIKH@28216|Betaproteobacteria	28216|Betaproteobacteria	L	Nucleotidyltransferase DNA polymerase involved in DNA repair	imuB	-	-	ko:K14161	-	-	-	-	ko00000,ko03400	-	-	-	IMS
HKD2_k127_102922_17	187272.Mlg_1095	8.67e-50	185.0	COG4544@1|root,COG4544@2|Bacteria,1MZQU@1224|Proteobacteria,1S9RP@1236|Gammaproteobacteria,1WZQP@135613|Chromatiales	135613|Chromatiales	D	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division	-	-	-	ko:K14160	-	-	-	-	ko00000,ko03400	-	-	-	SulA
HKD2_k127_102922_11	382245.ASA_4206	2.093e-77	264.0	COG1974@1|root,COG1974@2|Bacteria,1MW80@1224|Proteobacteria,1RMXF@1236|Gammaproteobacteria,1Y45U@135624|Aeromonadales	135624|Aeromonadales	K	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair	lexA	-	3.4.21.88	ko:K01356	-	M00729	-	-	ko00000,ko00002,ko01000,ko01002,ko03400	-	-	-	LexA_DNA_bind,Peptidase_S24
HKD2_k127_102922_8	1123368.AUIS01000007_gene2702	1.155e-94	323.0	COG1376@1|root,COG1376@2|Bacteria,1MVYT@1224|Proteobacteria,1RMNC@1236|Gammaproteobacteria,2NCX3@225057|Acidithiobacillales	225057|Acidithiobacillales	S	L,D-transpeptidase catalytic domain	-	-	-	ko:K16291	-	-	-	-	ko00000,ko01002,ko01011	-	-	-	LysM,YkuD
HKD2_k127_102922_20	1384056.N787_03245	2.11e-40	156.0	COG3339@1|root,COG3339@2|Bacteria,1RAN7@1224|Proteobacteria,1S291@1236|Gammaproteobacteria,1X60S@135614|Xanthomonadales	135614|Xanthomonadales	S	Protein of unknown function (DUF1232)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1232
HKD2_k127_102922_7	519989.ECTPHS_10366	5.329e-116	382.0	COG0416@1|root,COG0416@2|Bacteria,1MVM3@1224|Proteobacteria,1RM7R@1236|Gammaproteobacteria,1WW6R@135613|Chromatiales	135613|Chromatiales	I	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA	plsX	-	2.3.1.15	ko:K03621	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FA_synthesis
HKD2_k127_102922_23	765913.ThidrDRAFT_0401	4.767e-20	91.0	COG0333@1|root,COG0333@2|Bacteria,1N6RF@1224|Proteobacteria,1SC9G@1236|Gammaproteobacteria,1WZ7D@135613|Chromatiales	135613|Chromatiales	J	Belongs to the bacterial ribosomal protein bL32 family	rpmF	-	-	ko:K02911	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_L32p
HKD2_k127_102922_24	314285.KT71_15294	2.115e-12	74.0	COG1399@1|root,COG1399@2|Bacteria,1QRWX@1224|Proteobacteria,1SPQ0@1236|Gammaproteobacteria,1JAFW@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Uncharacterized ACR, COG1399	-	-	-	-	-	-	-	-	-	-	-	-	DUF177
HKD2_k127_102922_19	220341.16502359	2.599e-48	189.0	COG0424@1|root,COG0424@2|Bacteria,1RDA9@1224|Proteobacteria,1S3TQ@1236|Gammaproteobacteria,3ZKHI@590|Salmonella	1236|Gammaproteobacteria	D	Maf-like protein	yceF	GO:0003674,GO:0003824,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0047429	-	ko:K06287	-	-	-	-	ko00000	-	-	-	Maf
HKD2_k127_102922_9	637390.AFOH01000044_gene2192	1.412e-89	306.0	COG0564@1|root,COG0564@2|Bacteria,1MVDX@1224|Proteobacteria,1RPAN@1236|Gammaproteobacteria,2NC9N@225057|Acidithiobacillales	225057|Acidithiobacillales	G	Responsible for synthesis of pseudouridine from uracil	-	-	5.4.99.24	ko:K06179	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
HKD2_k127_102922_4	1286106.MPL1_11453	3.82e-152	486.0	COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,1RMDS@1236|Gammaproteobacteria,45ZQF@72273|Thiotrichales	72273|Thiotrichales	J	Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs	rne	-	3.1.26.12	ko:K08300	ko03018,map03018	M00394	-	-	ko00000,ko00001,ko00002,ko01000,ko03009,ko03019	-	-	-	RNase_E_G,S1
HKD2_k127_109166_7	1280953.HOC_00440	1.235e-101	346.0	COG1752@1|root,COG1752@2|Bacteria,1NT1Q@1224|Proteobacteria,2TRM3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	PFAM Patatin	MA20_41185	-	-	-	-	-	-	-	-	-	-	-	Patatin
HKD2_k127_109166_0	522306.CAP2UW1_0138	0.0	1644.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHZQ@28216|Betaproteobacteria	28216|Betaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
HKD2_k127_109166_6	522306.CAP2UW1_0137	7.777e-142	461.0	COG0845@1|root,COG0845@2|Bacteria,1PVWV@1224|Proteobacteria	1224|Proteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
HKD2_k127_109166_4	522306.CAP2UW1_0136	5.28e-183	585.0	COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,2VKED@28216|Betaproteobacteria	28216|Betaproteobacteria	M	TIGRFAM RND efflux system, outer membrane lipoprotein, NodT family	-	-	-	-	-	-	-	-	-	-	-	-	OEP
HKD2_k127_109166_10	522306.CAP2UW1_0135	3.891e-46	173.0	2BYGX@1|root,32U2R@2|Bacteria,1RCK4@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_109166_13	522306.CAP2UW1_0134	6.687e-27	116.0	2CHK6@1|root,333A9@2|Bacteria,1N9I7@1224|Proteobacteria,2VWH1@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_109166_14	1151127.KB906326_gene762	8.029e-16	79.0	297ZI@1|root,2ZV5N@2|Bacteria,1P53M@1224|Proteobacteria,1RVN4@1236|Gammaproteobacteria,1YU6E@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_109166_1	522306.CAP2UW1_0132	0.0	1082.0	COG0457@1|root,COG3710@1|root,COG3899@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,COG3899@2|Bacteria,1PG71@1224|Proteobacteria,2W8ZS@28216|Betaproteobacteria,1KR5S@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	K	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Trans_reg_C
HKD2_k127_109166_11	292415.Tbd_1279	4.437e-44	176.0	COG3528@1|root,COG3528@2|Bacteria,1R601@1224|Proteobacteria,2VPGW@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Uncharacterized protein conserved in bacteria (DUF2219)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2219
HKD2_k127_109166_15	1202532.FF52_20160	2.267e-12	73.0	2CWBN@1|root,32SZD@2|Bacteria,4NU6S@976|Bacteroidetes,1I6B8@117743|Flavobacteriia,2NW45@237|Flavobacterium	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_109166_2	414684.RC1_3030	1.084e-234	738.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2TRII@28211|Alphaproteobacteria,2JQ74@204441|Rhodospirillales	204441|Rhodospirillales	I	AMP-binding enzyme C-terminal domain	-	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
HKD2_k127_109166_9	1380394.JADL01000001_gene2375	3.824e-49	194.0	COG3287@1|root,COG3287@2|Bacteria,1MVUZ@1224|Proteobacteria,2TRRI@28211|Alphaproteobacteria,2JRCT@204441|Rhodospirillales	204441|Rhodospirillales	S	FIST N domain	-	-	-	-	-	-	-	-	-	-	-	-	FIST,FIST_C
HKD2_k127_109166_8	1149133.ppKF707_2868	3.387e-76	275.0	COG0784@1|root,COG4191@1|root,COG0784@2|Bacteria,COG4191@2|Bacteria,1QTVB@1224|Proteobacteria,1RYDJ@1236|Gammaproteobacteria,1YCRZ@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	T	PAS fold	pedS1	-	2.7.13.3	ko:K20975	ko02020,ko02025,map02020,map02025	M00820	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS_4,PAS_7,PAS_8,Response_reg
HKD2_k127_109166_12	371731.Rsw2DRAFT_3208	5.469e-42	162.0	COG2197@1|root,COG2197@2|Bacteria,1P4TD@1224|Proteobacteria,2U06A@28211|Alphaproteobacteria,1FBXW@1060|Rhodobacter	28211|Alphaproteobacteria	K	Two component transcriptional regulator, LuxR family	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HKD2_k127_109166_3	1244869.H261_20210	4.577e-192	614.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2TQR1@28211|Alphaproteobacteria,2JPZI@204441|Rhodospirillales	204441|Rhodospirillales	C	belongs to the aldehyde dehydrogenase family	puuC	-	1.2.1.54,1.2.1.99	ko:K09472,ko:K12254	ko00330,ko01100,map00330,map01100	M00136	R02549,R03177,R07417,R07418	RC00080	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
HKD2_k127_109166_5	1114964.L485_13405	2.692e-168	552.0	COG1629@1|root,COG4771@2|Bacteria,1MWKN@1224|Proteobacteria,2TVDT@28211|Alphaproteobacteria,2K0XE@204457|Sphingomonadales	204457|Sphingomonadales	P	TonB dependent receptor	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
HKD2_k127_111004_0	1161401.ASJA01000002_gene2611	3.198e-178	571.0	COG0457@1|root,COG0457@2|Bacteria,1MVMG@1224|Proteobacteria,2TSGE@28211|Alphaproteobacteria,43WYB@69657|Hyphomonadaceae	28211|Alphaproteobacteria	S	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_3,TPR_16,TPR_19,TPR_2,TPR_8
HKD2_k127_111004_1	983920.Y88_2802	4.269e-150	488.0	COG0477@1|root,COG2814@2|Bacteria,1NU31@1224|Proteobacteria,2U5M0@28211|Alphaproteobacteria,2KEAE@204457|Sphingomonadales	204457|Sphingomonadales	EGP	of the major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD2_k127_111004_2	999550.KI421507_gene2243	2.983e-22	102.0	COG2084@1|root,COG2084@2|Bacteria,1PU4S@1224|Proteobacteria,2TT0X@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid	-	-	1.1.1.31	ko:K00020	ko00280,ko01100,map00280,map01100	-	R05066	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
HKD2_k127_1164258_2	1042326.AZNV01000003_gene4001	5.945e-06	49.0	COG2128@1|root,COG2128@2|Bacteria,1RD1K@1224|Proteobacteria,2U6ZZ@28211|Alphaproteobacteria,4BE7D@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity	-	-	-	-	-	-	-	-	-	-	-	-	CMD
HKD2_k127_1164258_0	204773.HEAR2341	7.834e-124	406.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,2VH2F@28216|Betaproteobacteria,4736T@75682|Oxalobacteraceae	28216|Betaproteobacteria	P	Cation transporter/ATPase, N-terminus	mgtA	-	3.6.3.2	ko:K01531	-	-	-	-	ko00000,ko01000	3.A.3.4	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
HKD2_k127_1164258_1	1231391.AMZF01000025_gene1427	7.264e-109	360.0	COG0305@1|root,COG0305@2|Bacteria,1MUG9@1224|Proteobacteria,2VIKN@28216|Betaproteobacteria,3T2ZE@506|Alcaligenaceae	28216|Betaproteobacteria	L	it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins	dnaB	-	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C
HKD2_k127_1239507_0	666681.M301_0832	0.0	1577.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VK70@28216|Betaproteobacteria,2KM97@206350|Nitrosomonadales	206350|Nitrosomonadales	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
HKD2_k127_1239507_5	1122604.JONR01000003_gene1536	9.872e-39	151.0	COG1846@1|root,COG1846@2|Bacteria,1MZY5@1224|Proteobacteria,1SERB@1236|Gammaproteobacteria,1X6S6@135614|Xanthomonadales	135614|Xanthomonadales	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
HKD2_k127_1239507_4	1122604.JONR01000007_gene2930	1.286e-47	180.0	2BP41@1|root,32HUW@2|Bacteria,1NGA8@1224|Proteobacteria,1SH8K@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Bacterial protein of unknown function (Gcw_chp)	-	-	-	-	-	-	-	-	-	-	-	-	Gcw_chp
HKD2_k127_1239507_3	1122604.JONR01000007_gene2931	3.263e-51	188.0	COG1595@1|root,COG1595@2|Bacteria,1MVPD@1224|Proteobacteria,1SC6Q@1236|Gammaproteobacteria,1X520@135614|Xanthomonadales	135614|Xanthomonadales	K	Belongs to the sigma-70 factor family. ECF subfamily	rpoE4	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
HKD2_k127_1239507_6	1379701.JPJC01000141_gene75	4.17e-14	81.0	2ES5B@1|root,33JQ4@2|Bacteria,1NHPR@1224|Proteobacteria,2UN83@28211|Alphaproteobacteria,2K67H@204457|Sphingomonadales	204457|Sphingomonadales	S	Putative zinc-finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
HKD2_k127_1239507_1	1122604.JONR01000007_gene2933	4.085e-111	381.0	COG1404@1|root,COG1404@2|Bacteria,1R5T3@1224|Proteobacteria,1S4DV@1236|Gammaproteobacteria,1X58K@135614|Xanthomonadales	135614|Xanthomonadales	O	serine protease	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
HKD2_k127_1239507_2	1122604.JONR01000007_gene2936	2.329e-103	347.0	28P4Q@1|root,2ZBZV@2|Bacteria,1RA48@1224|Proteobacteria,1S347@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1239507_7	1134474.O59_000466	7.173e-13	75.0	2B7EF@1|root,320I7@2|Bacteria,1NDV8@1224|Proteobacteria,1SG78@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_124797_9	1500301.JQMF01000027_gene2933	3.344e-100	331.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2TQR1@28211|Alphaproteobacteria,4B7AV@82115|Rhizobiaceae	28211|Alphaproteobacteria	C	belongs to the aldehyde dehydrogenase family	-	-	1.2.1.99	ko:K09472	ko00330,ko01100,map00330,map01100	M00136	R07417,R07418	RC00080	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
HKD2_k127_124797_4	1161401.ASJA01000014_gene1032	1.105e-170	540.0	COG0714@1|root,COG0714@2|Bacteria,1MXIW@1224|Proteobacteria,2TS1Z@28211|Alphaproteobacteria,43W7S@69657|Hyphomonadaceae	28211|Alphaproteobacteria	S	cobaltochelatase subunit CobS	cobS	-	6.6.1.2	ko:K09882	ko00860,ko01100,map00860,map01100	-	R05227	RC02000	ko00000,ko00001,ko01000	-	-	-	AAA_5,CbbQ_C,CobS_N
HKD2_k127_124797_5	190650.CC_0672	5.706e-169	562.0	COG4547@1|root,COG4547@2|Bacteria,1MX11@1224|Proteobacteria,2TS4N@28211|Alphaproteobacteria,2KFC6@204458|Caulobacterales	204458|Caulobacterales	H	cobalt chelatase	-	-	6.6.1.2	ko:K09883	ko00860,ko01100,map00860,map01100	-	R05227	RC02000	ko00000,ko00001,ko01000	-	-	-	CobT,CobT_C
HKD2_k127_124797_14	1122132.AQYH01000018_gene1153	1.187e-44	167.0	COG3791@1|root,COG3791@2|Bacteria,1N031@1224|Proteobacteria,2UC7G@28211|Alphaproteobacteria,4BG5B@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Glutathione-dependent formaldehyde-activating enzyme	-	-	-	-	-	-	-	-	-	-	-	-	GFA
HKD2_k127_124797_6	1122612.AUBA01000009_gene2133	6.508e-128	419.0	COG0604@1|root,COG0604@2|Bacteria,1MX8A@1224|Proteobacteria,2TR1J@28211|Alphaproteobacteria,2K115@204457|Sphingomonadales	204457|Sphingomonadales	C	NADPH quinone	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_124797_8	1122612.AUBA01000025_gene3117	6.968e-110	363.0	COG0583@1|root,COG0583@2|Bacteria,1RBQE@1224|Proteobacteria,2U9HS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	LysR substrate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HKD2_k127_124797_10	1996.JOFO01000005_gene294	8.701e-99	331.0	COG1028@1|root,COG1028@2|Bacteria,2GJU1@201174|Actinobacteria,4EIGN@85012|Streptosporangiales	201174|Actinobacteria	IQ	KR domain	-	-	1.1.1.100,1.1.1.69	ko:K00046,ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HKD2_k127_124797_11	1267533.KB906733_gene3591	1.249e-92	321.0	COG2271@1|root,COG2271@2|Bacteria,3Y3W5@57723|Acidobacteria,2JK7R@204432|Acidobacteriia	204432|Acidobacteriia	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD2_k127_124797_3	1122612.AUBA01000010_gene115	4.369e-220	728.0	COG1053@1|root,COG1053@2|Bacteria,1QWW9@1224|Proteobacteria,2UQQQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_oxidored
HKD2_k127_124797_1	367299.JOEE01000012_gene3247	4.324e-282	878.0	COG2303@1|root,COG2303@2|Bacteria,2GJAU@201174|Actinobacteria,4FGN4@85021|Intrasporangiaceae	201174|Actinobacteria	E	GMC oxidoreductase	betA	-	1.1.99.1	ko:K00108	ko00260,ko01100,map00260,map01100	M00555	R01025	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	GMC_oxred_C,GMC_oxred_N
HKD2_k127_124797_7	344747.PM8797T_23886	2.173e-112	369.0	COG0190@1|root,COG0190@2|Bacteria,2IXS4@203682|Planctomycetes	203682|Planctomycetes	F	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate	folD	GO:0003674,GO:0003824,GO:0004477,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0019238,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114	1.5.1.5,3.5.4.9	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R01220,R01655	RC00202,RC00578	ko00000,ko00001,ko00002,ko01000	-	-	-	THF_DHG_CYH,THF_DHG_CYH_C
HKD2_k127_124797_16	316058.RPB_0722	1.119e-13	76.0	2E4CR@1|root,32Z86@2|Bacteria,1N7UZ@1224|Proteobacteria,2UF9N@28211|Alphaproteobacteria,3K0B2@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	NADH-dependant formate dehydrogenase delta subunit FdsD	fdsD	-	1.17.1.9	ko:K00126	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	FdsD
HKD2_k127_124797_0	1122604.JONR01000032_gene81	0.0	1475.0	COG3383@1|root,COG3383@2|Bacteria,1QTZB@1224|Proteobacteria,1T1JA@1236|Gammaproteobacteria,1X3JM@135614|Xanthomonadales	135614|Xanthomonadales	C	Molybdopterin oxidoreductase Fe4S4 domain	-	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Fer2_4,Fer4,Fer4_7,Fer4_9,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
HKD2_k127_124797_2	795666.MW7_2876	6.14e-233	730.0	COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,2VIGR@28216|Betaproteobacteria,1K3B8@119060|Burkholderiaceae	28216|Betaproteobacteria	C	PFAM Respiratory-chain NADH dehydrogenase domain 51 kDa subunit	fdsB	-	-	ko:K00124	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001	-	-	-	Complex1_51K,NADH_4Fe-4S,SLBB
HKD2_k127_124797_12	1234364.AMSF01000088_gene2739	2.178e-51	187.0	COG1905@1|root,COG1905@2|Bacteria,1RHBU@1224|Proteobacteria,1T09A@1236|Gammaproteobacteria,1XCZH@135614|Xanthomonadales	135614|Xanthomonadales	C	Thioredoxin-like [2Fe-2S] ferredoxin	-	-	-	-	-	-	-	-	-	-	-	-	2Fe-2S_thioredx
HKD2_k127_124797_13	1121918.ARWE01000001_gene424	1.564e-47	185.0	COG1832@1|root,COG1832@2|Bacteria,1NJW8@1224|Proteobacteria,42WY1@68525|delta/epsilon subdivisions,2WT3S@28221|Deltaproteobacteria,43UZ1@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	CoA binding domain	-	-	-	-	-	-	-	-	-	-	-	-	CoA_binding_2
HKD2_k127_124797_15	1049564.TevJSym_ag00540	1.528e-17	82.0	COG1714@1|root,COG1714@2|Bacteria,1MZAD@1224|Proteobacteria,1S6E9@1236|Gammaproteobacteria,1J6IT@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	membrane protein domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4339,RDD
HKD2_k127_1329499_2	351160.RCIX2624	1.822e-11	70.0	COG2033@1|root,arCOG02146@2157|Archaea,2XXQW@28890|Euryarchaeota,2NAZH@224756|Methanomicrobia	224756|Methanomicrobia	C	Desulfoferrodoxin	sor	-	1.15.1.2	ko:K05919	-	-	-	-	ko00000,ko01000	-	-	-	Desulfoferrodox
HKD2_k127_1329499_1	671143.DAMO_2594	5.835e-37	142.0	COG0745@1|root,COG0745@2|Bacteria	671143.DAMO_2594|-	T	phosphorelay signal transduction system	-	-	-	ko:K11443	ko02020,ko04112,map02020,map04112	M00511	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	-
HKD2_k127_1329499_0	1038860.AXAP01000143_gene4099	5.505e-87	296.0	COG0642@1|root,COG3850@1|root,COG2205@2|Bacteria,COG3850@2|Bacteria,1NRP8@1224|Proteobacteria,2TX3Q@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Histidine kinase-like ATPases	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HAMP,HATPase_c,HisKA,Response_reg,dCache_1
HKD2_k127_1355210_12	713586.KB900536_gene2820	1.935e-21	94.0	COG0644@1|root,COG0644@2|Bacteria,1MXQY@1224|Proteobacteria,1SEJ8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	geranylgeranyl reductase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3
HKD2_k127_1355210_0	713586.KB900536_gene2819	6.797e-144	470.0	COG2230@1|root,COG2230@2|Bacteria,1MX3U@1224|Proteobacteria,1S1KY@1236|Gammaproteobacteria,1X28H@135613|Chromatiales	135613|Chromatiales	M	Mycolic acid cyclopropane synthetase	-	-	2.1.1.79	ko:K00574	-	-	-	-	ko00000,ko01000	-	-	-	CMAS
HKD2_k127_1355210_5	65393.PCC7424_4594	1.265e-60	229.0	COG3379@1|root,COG3379@2|Bacteria,1G1KP@1117|Cyanobacteria	1117|Cyanobacteria	S	type I phosphodiesterase nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
HKD2_k127_1355210_8	319003.Bra1253DRAFT_03050	1.563e-40	165.0	COG1835@1|root,COG1835@2|Bacteria	2|Bacteria	I	transferase activity, transferring acyl groups other than amino-acyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
HKD2_k127_1355210_1	1123278.KB893455_gene810	1.781e-84	307.0	COG1807@1|root,COG1807@2|Bacteria,4NG1F@976|Bacteroidetes,47NSA@768503|Cytophagia	976|Bacteroidetes	M	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family	-	-	-	-	-	-	-	-	-	-	-	-	DUF2723,PMT_2
HKD2_k127_1355210_2	396588.Tgr7_2677	3.278e-82	282.0	COG1628@1|root,COG1628@2|Bacteria,1RCX1@1224|Proteobacteria	1224|Proteobacteria	S	Protein of unknown function DUF99	-	-	-	ko:K09120	-	-	-	-	ko00000	-	-	-	DUF99
HKD2_k127_1355210_18	626887.J057_18705	6.641e-10	68.0	COG2063@1|root,COG2063@2|Bacteria,1NJPK@1224|Proteobacteria,1SJA9@1236|Gammaproteobacteria	1236|Gammaproteobacteria	N	Fibronectin type 3 domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1355210_6	1385517.N800_10830	4.207e-50	187.0	COG0398@1|root,COG0398@2|Bacteria,1N99S@1224|Proteobacteria	1224|Proteobacteria	S	SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
HKD2_k127_1355210_14	395494.Galf_2212	4.569e-18	89.0	COG4575@1|root,COG4575@2|Bacteria,1N6X7@1224|Proteobacteria,2WFR8@28216|Betaproteobacteria,44WIE@713636|Nitrosomonadales	28216|Betaproteobacteria	S	Bacterial protein of unknown function (DUF883)	-	-	-	-	-	-	-	-	-	-	-	-	DUF883
HKD2_k127_1355210_7	1049564.TevJSym_ad00220	9.978e-50	199.0	COG0515@1|root,COG0515@2|Bacteria,1MWVZ@1224|Proteobacteria,1RQBQ@1236|Gammaproteobacteria,1J4P6@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	KLT	COG0515 Serine threonine protein kinase	stk1	-	2.7.11.1	ko:K08282,ko:K11916,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001,ko02044	-	-	-	FGE-sulfatase,Pkinase
HKD2_k127_1355210_9	1005395.CSV86_24959	2.316e-28	120.0	COG1695@1|root,COG1695@2|Bacteria,1RHG3@1224|Proteobacteria,1SD48@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	PadR
HKD2_k127_1355210_19	596151.DesfrDRAFT_2898	4.674e-07	62.0	COG2755@1|root,COG2755@2|Bacteria,1NHW6@1224|Proteobacteria,42XAM@68525|delta/epsilon subdivisions,2WSXZ@28221|Deltaproteobacteria,2MDU0@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	GDSL-like Lipase/Acylhydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
HKD2_k127_1355210_4	452662.SJA_C2-02040	8.386e-61	228.0	COG0451@1|root,COG0451@2|Bacteria,1MW32@1224|Proteobacteria,2TTTU@28211|Alphaproteobacteria,2K23Q@204457|Sphingomonadales	204457|Sphingomonadales	M	NAD-dependent epimerase dehydratase	-	-	1.1.1.219	ko:K00091	-	-	-	-	ko00000,ko01000	-	-	-	Epimerase
HKD2_k127_1355210_16	1379698.RBG1_1C00001G0382	4.334e-15	87.0	COG5653@1|root,COG5653@2|Bacteria	2|Bacteria	M	Protein involved in cellulose biosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_6
HKD2_k127_1355210_20	240016.ABIZ01000001_gene5365	5.002e-07	62.0	COG1524@1|root,COG1524@2|Bacteria,46XAN@74201|Verrucomicrobia,2IV7D@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Type I phosphodiesterase / nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
HKD2_k127_1355210_21	1123073.KB899241_gene2085	2.21e-06	59.0	COG0392@1|root,COG0392@2|Bacteria,1QCDR@1224|Proteobacteria,1T83P@1236|Gammaproteobacteria,1XBRH@135614|Xanthomonadales	135614|Xanthomonadales	S	Lysylphosphatidylglycerol synthase TM region	-	-	-	-	-	-	-	-	-	-	-	-	LPG_synthase_TM
HKD2_k127_1355210_3	666685.R2APBS1_2349	2.083e-72	252.0	28PFD@1|root,2ZC6I@2|Bacteria,1R8PT@1224|Proteobacteria,1S2BA@1236|Gammaproteobacteria,1XABJ@135614|Xanthomonadales	135614|Xanthomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1355210_13	1454004.AW11_00270	5.084e-19	91.0	2DSS3@1|root,33H86@2|Bacteria,1NI05@1224|Proteobacteria,2W5BA@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1355210_17	1123261.AXDW01000017_gene3177	6.036e-10	72.0	COG5276@1|root,COG5276@2|Bacteria,1QVI5@1224|Proteobacteria	1224|Proteobacteria	N	alpha-L-arabinofuranosidase	-	-	-	-	-	-	-	-	-	-	-	-	FG-GAP,He_PIG,LVIVD
HKD2_k127_1355210_15	671143.DAMO_0449	3.204e-16	93.0	COG1572@1|root,COG1572@2|Bacteria	2|Bacteria	NU	bacterial-type flagellum-dependent cell motility	-	-	-	-	-	-	-	-	-	-	-	-	DUF11,DUF3367,DUF5122,HemolysinCabind,NPCBM
HKD2_k127_1355210_10	1123257.AUFV01000001_gene1791	5.951e-23	113.0	COG2373@1|root,COG2730@1|root,COG2373@2|Bacteria,COG2730@2|Bacteria,1RCG4@1224|Proteobacteria,1RXYQ@1236|Gammaproteobacteria,1XCHV@135614|Xanthomonadales	135614|Xanthomonadales	G	Endoglucanase	-	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	CBM_2,Calx-beta,Cellulase
HKD2_k127_1375885_0	292415.Tbd_0367	1.409e-127	422.0	COG1392@1|root,COG1392@2|Bacteria,1MW5V@1224|Proteobacteria,2VM9A@28216|Betaproteobacteria,1KRYF@119069|Hydrogenophilales	119069|Hydrogenophilales	P	Phosphate transport regulator	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1375885_1	1089544.KB912942_gene1762	7.109e-111	370.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,2GK73@201174|Actinobacteria,4E0F3@85010|Pseudonocardiales	201174|Actinobacteria	G	PEP-utilising enzyme, mobile domain	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
HKD2_k127_1376760_0	204669.Acid345_4693	4.29e-65	242.0	COG1574@1|root,COG1574@2|Bacteria,3Y2UF@57723|Acidobacteria,2JIRH@204432|Acidobacteriia	57723|Acidobacteria	S	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
HKD2_k127_1376760_1	1234364.AMSF01000010_gene479	3.179e-53	192.0	COG3428@1|root,COG3428@2|Bacteria,1NHMM@1224|Proteobacteria,1T998@1236|Gammaproteobacteria,1XBUQ@135614|Xanthomonadales	135614|Xanthomonadales	S	Bacterial PH domain	-	-	-	-	-	-	-	-	-	-	-	-	bPH_2
HKD2_k127_1380787_23	215803.DB30_7506	1.624e-63	230.0	COG0132@1|root,COG0132@2|Bacteria,1MYAE@1224|Proteobacteria,438QP@68525|delta/epsilon subdivisions,2X92A@28221|Deltaproteobacteria,2YXIK@29|Myxococcales	28221|Deltaproteobacteria	H	Domain of unknown function (DUF1611_C) P-loop domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF1611
HKD2_k127_1380787_4	518766.Rmar_0950	1.844e-118	401.0	COG0137@1|root,COG0137@2|Bacteria,4NE3R@976|Bacteroidetes,1FJVB@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	H	Belongs to the argininosuccinate synthase family. Type 1 subfamily	argG	-	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Arginosuc_synth
HKD2_k127_1380787_33	477974.Daud_1030	2.997e-23	105.0	COG1438@1|root,COG1438@2|Bacteria,1V1R7@1239|Firmicutes,24HGQ@186801|Clostridia,2625T@186807|Peptococcaceae	186801|Clostridia	K	Regulates arginine biosynthesis genes	argR	-	-	ko:K03402	-	-	-	-	ko00000,ko03000	-	-	-	Arg_repressor,Arg_repressor_C
HKD2_k127_1380787_15	342610.Patl_2769	6.71e-79	275.0	2BFHU@1|root,2Z8VP@2|Bacteria,1QR3R@1224|Proteobacteria,1SJVS@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1380787_22	1380394.JADL01000005_gene5553	2.406e-66	232.0	COG1051@1|root,COG1051@2|Bacteria,1RH0I@1224|Proteobacteria,2UB84@28211|Alphaproteobacteria,2JWEM@204441|Rhodospirillales	204441|Rhodospirillales	F	Hydrolase of X-linked nucleoside diphosphate N terminal	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX,Nudix_N
HKD2_k127_1380787_5	472759.Nhal_0217	8.369e-118	421.0	COG2911@1|root,COG2911@2|Bacteria,1MUVD@1224|Proteobacteria,1RMMF@1236|Gammaproteobacteria,1WWU1@135613|Chromatiales	135613|Chromatiales	S	TamB, inner membrane protein subunit of TAM complex	-	-	-	ko:K09800	-	-	-	-	ko00000,ko02000	-	-	-	TamB
HKD2_k127_1380787_11	472759.Nhal_0216	3.168e-95	337.0	COG0729@1|root,COG0729@2|Bacteria,1MUKM@1224|Proteobacteria,1RNQ3@1236|Gammaproteobacteria,1WWT6@135613|Chromatiales	135613|Chromatiales	M	Surface antigen variable number	-	-	-	ko:K07278	-	-	-	-	ko00000,ko02000	1.B.33.2.4	-	-	Bac_surface_Ag,POTRA,POTRA_TamA_1
HKD2_k127_1380787_19	338963.Pcar_0026	5.124e-71	250.0	COG3332@1|root,COG3332@2|Bacteria,1RDBS@1224|Proteobacteria,42QS8@68525|delta/epsilon subdivisions,2WMV7@28221|Deltaproteobacteria,43SGZ@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Transport and Golgi organisation 2	-	-	-	-	-	-	-	-	-	-	-	-	TANGO2
HKD2_k127_1380787_28	1038860.AXAP01000003_gene8172	3.438e-46	173.0	2DM5T@1|root,31U0Y@2|Bacteria,1RJ9U@1224|Proteobacteria,2UA0D@28211|Alphaproteobacteria,3JZFV@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Domain of unknown function (DUF4126)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4126
HKD2_k127_1380787_18	1366050.N234_20420	1.434e-72	254.0	COG0730@1|root,COG0730@2|Bacteria,1MXNM@1224|Proteobacteria,2VHQA@28216|Betaproteobacteria,1K0DF@119060|Burkholderiaceae	28216|Betaproteobacteria	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
HKD2_k127_1380787_13	335543.Sfum_1412	1.768e-85	293.0	COG2816@1|root,COG2816@2|Bacteria,1QGCX@1224|Proteobacteria,42R10@68525|delta/epsilon subdivisions,2WN3Z@28221|Deltaproteobacteria,2MQIY@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	NADH pyrophosphatase zinc ribbon domain	nudC	-	3.6.1.22	ko:K03426	ko00760,ko01100,ko04146,map00760,map01100,map04146	-	R00103,R03004,R11104	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX,NUDIX-like,zf-NADH-PPase
HKD2_k127_1380787_3	722419.PH505_bj00030	3.799e-125	416.0	COG1131@1|root,COG1131@2|Bacteria,1MUW7@1224|Proteobacteria,1RMC5@1236|Gammaproteobacteria,2PZY3@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	V	COG1131 ABC-type multidrug transport system, ATPase component	yadG	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0009314,GO:0009628,GO:0010165,GO:0010212,GO:0016020,GO:0044464,GO:0050896,GO:0071944	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD2_k127_1380787_9	1429851.X548_18250	5.745e-104	349.0	COG0842@1|root,COG0842@2|Bacteria,1MUH1@1224|Proteobacteria,1RP0Z@1236|Gammaproteobacteria,1X38I@135614|Xanthomonadales	135614|Xanthomonadales	V	Transport permease protein	yadH	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
HKD2_k127_1380787_24	118166.JH976537_gene4842	3.949e-63	224.0	COG2135@1|root,COG2135@2|Bacteria,1G1SA@1117|Cyanobacteria,1HAGW@1150|Oscillatoriales	1117|Cyanobacteria	S	Belongs to the SOS response-associated peptidase family	-	-	-	-	-	-	-	-	-	-	-	-	SRAP
HKD2_k127_1380787_36	1388763.O165_002245	3.105e-06	54.0	2DMIH@1|root,32RT1@2|Bacteria,1RDKU@1224|Proteobacteria,1S9NM@1236|Gammaproteobacteria,1YW9H@136845|Pseudomonas putida group	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1380787_31	861299.J421_6050	1.542e-32	139.0	COG0457@1|root,COG0457@2|Bacteria	861299.J421_6050|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1380787_21	883126.HMPREF9710_00664	5.787e-69	247.0	COG0438@1|root,COG0438@2|Bacteria,1N0VQ@1224|Proteobacteria	1224|Proteobacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_2
HKD2_k127_1380787_25	1499684.CCNP01000026_gene3737	4.146e-62	238.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
HKD2_k127_1380787_32	1463936.JOJI01000021_gene396	2.341e-23	116.0	COG2520@1|root,COG2520@2|Bacteria,2I388@201174|Actinobacteria	201174|Actinobacteria	J	Methyltransferase FkbM domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_21
HKD2_k127_1380787_2	240016.ABIZ01000001_gene4226	1.394e-152	498.0	COG3119@1|root,COG3119@2|Bacteria,46TYX@74201|Verrucomicrobia,2IVJJ@203494|Verrucomicrobiae	203494|Verrucomicrobiae	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
HKD2_k127_1380787_27	1343739.PAP_09925	4.354e-50	189.0	COG0463@1|root,arCOG01381@2157|Archaea,2XY5X@28890|Euryarchaeota	28890|Euryarchaeota	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HKD2_k127_1380787_0	768671.ThimaDRAFT_3413	7.173e-297	924.0	COG0480@1|root,COG0480@2|Bacteria,1MVVY@1224|Proteobacteria,1RYCE@1236|Gammaproteobacteria,1WWXP@135613|Chromatiales	135613|Chromatiales	J	small GTP-binding protein	-	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU
HKD2_k127_1380787_30	247633.GP2143_08469	4.97e-43	175.0	COG2199@1|root,COG3706@2|Bacteria,1QVPW@1224|Proteobacteria,1T2GC@1236|Gammaproteobacteria,1JAKM@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
HKD2_k127_1380787_12	96561.Dole_0172	3.282e-86	300.0	COG0429@1|root,COG0429@2|Bacteria,1MWV1@1224|Proteobacteria,42S0M@68525|delta/epsilon subdivisions,2WNYE@28221|Deltaproteobacteria,2MMEA@213118|Desulfobacterales	28221|Deltaproteobacteria	S	alpha/beta hydrolase fold	yheT	-	-	ko:K07019	-	-	-	-	ko00000	-	-	-	Abhydrolase_1,Abhydrolase_6
HKD2_k127_1380787_8	670487.Ocepr_0084	2.005e-104	358.0	COG0554@1|root,COG0554@2|Bacteria,1WI6Q@1297|Deinococcus-Thermus	2|Bacteria	C	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate	-	-	2.7.1.30	ko:K00864	ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626	-	R00847	RC00002,RC00017	ko00000,ko00001,ko01000,ko04147	-	-	-	FGGY_C,FGGY_N
HKD2_k127_1380787_26	472759.Nhal_1457	1.842e-50	188.0	COG0584@1|root,COG0584@2|Bacteria,1MU8H@1224|Proteobacteria,1RQWX@1236|Gammaproteobacteria,1WZGU@135613|Chromatiales	135613|Chromatiales	C	PFAM Glycerophosphoryl diester phosphodiesterase	-	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD
HKD2_k127_1380787_29	102232.GLO73106DRAFT_00029160	8.943e-46	175.0	COG2859@1|root,COG2859@2|Bacteria,1G4NY@1117|Cyanobacteria	1117|Cyanobacteria	S	periplasmic protein	-	-	-	ko:K09797	-	-	-	-	ko00000	-	-	-	SIMPL
HKD2_k127_1380787_17	228405.HNE_1455	6.281e-77	265.0	28PH0@1|root,2ZC7M@2|Bacteria,1R6YG@1224|Proteobacteria,2U2A9@28211|Alphaproteobacteria,43ZS3@69657|Hyphomonadaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1380787_1	935567.JAES01000003_gene234	4.067e-184	584.0	COG1960@1|root,COG1960@2|Bacteria,1MUK0@1224|Proteobacteria,1RNBX@1236|Gammaproteobacteria,1X45S@135614|Xanthomonadales	135614|Xanthomonadales	I	Acyl-CoA dehydrogenase	gcdH	-	1.3.8.6	ko:K00252	ko00071,ko00310,ko00362,ko00380,ko01100,ko01120,ko01130,map00071,map00310,map00362,map00380,map01100,map01120,map01130	M00032	R02487,R02488,R10074	RC00052,RC00156	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HKD2_k127_1380787_34	56780.SYN_01961	7.86e-21	102.0	COG3409@1|root,COG3409@2|Bacteria	2|Bacteria	M	Peptidoglycan-binding domain 1 protein	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_25,LysM,PG_binding_1,Peptidase_C14
HKD2_k127_1380787_35	930169.B5T_00376	3.938e-14	76.0	COG1652@1|root,COG1652@2|Bacteria,1RD8K@1224|Proteobacteria,1S4CB@1236|Gammaproteobacteria,1XPHR@135619|Oceanospirillales	135619|Oceanospirillales	S	BON domain	-	-	-	-	-	-	-	-	-	-	-	-	BON,LysM
HKD2_k127_1380787_10	309807.SRU_2067	4.011e-99	337.0	COG0123@1|root,COG0123@2|Bacteria,4NF3X@976|Bacteroidetes,1FJXN@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	BQ	Histone deacetylase domain	-	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
HKD2_k127_1380787_20	1300345.LF41_813	5.213e-69	242.0	COG2885@1|root,COG2885@2|Bacteria,1MYBP@1224|Proteobacteria,1RVRF@1236|Gammaproteobacteria,1X4JP@135614|Xanthomonadales	135614|Xanthomonadales	M	Belongs to the ompA family	-	-	-	-	-	-	-	-	-	-	-	-	Gly-zipper_Omp,Gly-zipper_YMGG,OmpA
HKD2_k127_1380787_7	1205753.A989_09551	5.072e-108	357.0	COG0568@1|root,COG0568@2|Bacteria,1MVWR@1224|Proteobacteria,1RMFR@1236|Gammaproteobacteria,1X3U9@135614|Xanthomonadales	135614|Xanthomonadales	K	RNA polymerase sigma factor RpoH	rpoH	-	-	ko:K03089	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r4
HKD2_k127_1380787_16	1049564.TevJSym_aa00850	6.294e-78	270.0	COG2177@1|root,COG2177@2|Bacteria,1MU65@1224|Proteobacteria,1RYBV@1236|Gammaproteobacteria,1J4H6@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	D	Part of the ABC transporter FtsEX involved in cellular division	ftsX	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0009274,GO:0009276,GO:0009987,GO:0016020,GO:0016021,GO:0030312,GO:0030313,GO:0031224,GO:0031975,GO:0032153,GO:0044425,GO:0044464,GO:0051301,GO:0071944	-	ko:K09811	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	FtsX
HKD2_k127_1380787_14	768671.ThimaDRAFT_2658	3.837e-85	297.0	COG2884@1|root,COG2884@2|Bacteria,1MVQ4@1224|Proteobacteria,1RMZA@1236|Gammaproteobacteria,1WWPI@135613|Chromatiales	135613|Chromatiales	D	TIGRFAM Cell division ATP-binding protein FtsE	-	-	-	ko:K09812	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	ABC_tran
HKD2_k127_1380787_6	396588.Tgr7_2988	4.609e-108	355.0	COG0552@1|root,COG0552@2|Bacteria,1MUDU@1224|Proteobacteria,1RNIN@1236|Gammaproteobacteria,1WW5G@135613|Chromatiales	135613|Chromatiales	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components	ftsY	-	-	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2,3.A.5.7	-	-	SRP54,SRP54_N
HKD2_k127_1381126_2	157783.LK03_13635	5.067e-98	326.0	COG0583@1|root,COG0583@2|Bacteria,1MU8N@1224|Proteobacteria,1RN7T@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	transcriptional regulator	cysB	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009314,GO:0009628,GO:0010165,GO:0010212,GO:0042802,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0097159,GO:1901363	-	ko:K13634	-	-	-	-	ko00000,ko03000	-	-	-	HTH_1,LysR_substrate
HKD2_k127_1381126_0	323261.Noc_2003	4.527e-183	587.0	COG0606@1|root,COG0606@2|Bacteria,1MU4R@1224|Proteobacteria,1RMB9@1236|Gammaproteobacteria,1WWMF@135613|Chromatiales	135613|Chromatiales	O	PFAM Magnesium chelatase, ChlI subunit	-	-	-	ko:K07391	-	-	-	-	ko00000	-	-	-	ChlI,Mg_chelatase,Mg_chelatase_C
HKD2_k127_1381126_1	1403819.BATR01000053_gene1641	2.728e-182	634.0	COG3209@1|root,COG3209@2|Bacteria,46UCN@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Insecticide toxin TcdB middle/N-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	RHS_repeat,VCBS
HKD2_k127_1393252_0	452637.Oter_0894	0.0	1347.0	COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,46U9T@74201|Verrucomicrobia,3K7GP@414999|Opitutae	414999|Opitutae	E	glutamate synthase	-	-	1.4.7.1	ko:K00284	ko00630,ko00910,ko01120,map00630,map00910,map01120	-	R00021,R10086	RC00006,RC00010	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
HKD2_k127_1393252_26	443144.GM21_2774	7.311e-10	63.0	COG2261@1|root,COG2261@2|Bacteria,1NGEB@1224|Proteobacteria,42VUV@68525|delta/epsilon subdivisions,2WS8X@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Transglycosylase associated protein	-	-	-	-	-	-	-	-	-	-	-	-	Transgly_assoc
HKD2_k127_1393252_23	1452718.JBOY01000059_gene1585	4.947e-32	130.0	COG0797@1|root,COG0797@2|Bacteria,1MZ8S@1224|Proteobacteria,1RMCG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides	rlpA	-	-	ko:K03642	-	-	-	-	ko00000	-	-	-	DPBB_1,SPOR
HKD2_k127_1393252_15	95619.PM1_0211110	1.15e-71	253.0	COG0657@1|root,COG0657@2|Bacteria,1RD8A@1224|Proteobacteria,1S3TH@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	esterase lipase	-	-	3.1.1.83	ko:K14731	ko00903,ko00930,ko01220,map00903,map00930,map01220	-	R03751,R06390,R06391,R06392,R06393	RC00713,RC00983,RC01505	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_3
HKD2_k127_1393252_16	1149133.ppKF707_1011	5.287e-67	241.0	COG0657@1|root,COG0657@2|Bacteria,1RD8A@1224|Proteobacteria,1S3TH@1236|Gammaproteobacteria,1YCYX@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	I	Steryl acetyl hydrolase	-	-	3.1.1.83	ko:K14731	ko00903,ko00930,ko01220,map00903,map00930,map01220	-	R03751,R06390,R06391,R06392,R06393	RC00713,RC00983,RC01505	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_3
HKD2_k127_1393252_22	1333856.L686_07175	2.172e-33	149.0	COG1309@1|root,COG1309@2|Bacteria,1R52P@1224|Proteobacteria,1S7AF@1236|Gammaproteobacteria,1YZYJ@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	K	Transcriptional regulator	phaD	-	-	-	-	-	-	-	-	-	-	-	TetR,TetR_N
HKD2_k127_1393252_12	349163.Acry_1262	3.86e-106	357.0	COG3239@1|root,COG3239@2|Bacteria,1MW29@1224|Proteobacteria,2TSHW@28211|Alphaproteobacteria,2JX06@204441|Rhodospirillales	204441|Rhodospirillales	C	Fatty acid desaturase	-	-	1.14.15.3	ko:K00496	ko00071,ko00930,map00071,map00930	-	R01347,R02281,R06945	RC00478	ko00000,ko00001,ko01000	-	-	-	FA_desaturase
HKD2_k127_1393252_25	399739.Pmen_2542	1.182e-25	110.0	COG0543@1|root,COG1018@1|root,COG0543@2|Bacteria,COG1018@2|Bacteria,1MV72@1224|Proteobacteria,1T4D8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Oxidoreductase FAD-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	DHODB_Fe-S_bind,FAD_binding_6,Fer2,NAD_binding_1
HKD2_k127_1393252_17	1439940.BAY1663_02410	6.933e-62	224.0	COG3145@1|root,COG3145@2|Bacteria,1RGXU@1224|Proteobacteria,1S6DD@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Alkylated DNA repair protein	alkB	-	-	-	-	-	-	-	-	-	-	-	2OG-FeII_Oxy_2
HKD2_k127_1393252_21	572477.Alvin_0439	5.831e-37	143.0	COG2010@1|root,COG2010@2|Bacteria,1NDHN@1224|Proteobacteria,1S700@1236|Gammaproteobacteria,1WYGG@135613|Chromatiales	135613|Chromatiales	C	Planctomycete cytochrome C	-	-	-	-	-	-	-	-	-	-	-	-	PSCyt1
HKD2_k127_1393252_24	1390370.O203_20030	5.912e-26	117.0	COG3226@1|root,COG3226@2|Bacteria,1NNVA@1224|Proteobacteria,1S5F9@1236|Gammaproteobacteria,1YISA@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
HKD2_k127_1393252_19	247633.GP2143_11499	2.156e-51	189.0	COG2863@1|root,COG2863@2|Bacteria,1QXWH@1224|Proteobacteria,1T3IQ@1236|Gammaproteobacteria,1J6M9@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	COG2863 Cytochrome c553	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,ThuA
HKD2_k127_1393252_8	314285.KT71_07749	2.971e-170	543.0	COG1858@1|root,COG1858@2|Bacteria,1MV70@1224|Proteobacteria,1RPPQ@1236|Gammaproteobacteria,1J7GB@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	COG1858 Cytochrome c peroxidase	-	-	1.11.1.5	ko:K00428	-	-	-	-	ko00000,ko01000	-	-	-	CCP_MauG,Cytochrom_C
HKD2_k127_1393252_4	425104.Ssed_1106	2.195e-225	708.0	COG2010@1|root,COG3420@1|root,COG2010@2|Bacteria,COG3420@2|Bacteria,1QUPB@1224|Proteobacteria,1T2I7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	COG3420 Nitrous oxidase accessory protein	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,NosD
HKD2_k127_1393252_2	1121015.N789_13860	4.96e-288	924.0	COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,1MWKN@1224|Proteobacteria,1T5NS@1236|Gammaproteobacteria,1XDDS@135614|Xanthomonadales	135614|Xanthomonadales	P	TonB dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
HKD2_k127_1393252_1	1282876.BAOK01000002_gene221	4.455e-290	907.0	COG2010@1|root,COG4993@1|root,COG2010@2|Bacteria,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,2TS2Q@28211|Alphaproteobacteria,4BTBE@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	CG	PQQ enzyme repeat	-	-	1.1.9.1	ko:K17760	-	-	-	-	ko00000,ko01000	-	-	-	Cytochrome_CBB3,PQQ,PQQ_2
HKD2_k127_1393252_10	1089547.KB913013_gene2997	3.443e-134	443.0	COG0154@1|root,COG0154@2|Bacteria,4NKM3@976|Bacteroidetes,47P35@768503|Cytophagia	976|Bacteroidetes	J	Belongs to the amidase family	-	-	3.5.1.4,6.3.5.6,6.3.5.7	ko:K01426,ko:K02433	ko00330,ko00360,ko00380,ko00627,ko00643,ko00970,ko01100,ko01120,map00330,map00360,map00380,map00627,map00643,map00970,map01100,map01120	-	R02540,R03096,R03180,R03905,R03909,R04212,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
HKD2_k127_1393252_3	1205680.CAKO01000006_gene3326	3.461e-266	833.0	COG0129@1|root,COG0129@2|Bacteria,1MUTQ@1224|Proteobacteria,2TRTQ@28211|Alphaproteobacteria,2JPT6@204441|Rhodospirillales	204441|Rhodospirillales	E	Belongs to the IlvD Edd family	ilvD	-	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
HKD2_k127_1393252_7	1122604.JONR01000047_gene2049	2.07e-176	560.0	COG1257@1|root,COG1257@2|Bacteria,1Q6M1@1224|Proteobacteria,1RPEP@1236|Gammaproteobacteria,1X2Y1@135614|Xanthomonadales	135614|Xanthomonadales	I	Hydroxymethylglutaryl-coenzyme A reductase	-	-	-	-	-	-	-	-	-	-	-	-	HMG-CoA_red
HKD2_k127_1393252_13	425104.Ssed_2733	8.748e-103	371.0	COG1454@1|root,COG1454@2|Bacteria,1MVPH@1224|Proteobacteria,1RMVU@1236|Gammaproteobacteria,2QDHI@267890|Shewanellaceae	1236|Gammaproteobacteria	C	Iron-containing alcohol dehydrogenase	-	-	1.1.1.1	ko:K00001	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	Fe-ADH
HKD2_k127_1393252_5	660470.Theba_1756	1.922e-202	642.0	COG3119@1|root,COG3119@2|Bacteria	2|Bacteria	P	arylsulfatase activity	aslA	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase,Sulfatase_C
HKD2_k127_1393252_6	1411685.U062_01569	2.778e-198	648.0	COG0318@1|root,COG0318@2|Bacteria,1MUMC@1224|Proteobacteria,1RMGS@1236|Gammaproteobacteria,1J5JZ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	IQ	COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II	alkK	-	6.2.1.44	ko:K20034	ko00920,map00920	-	R10820	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C
HKD2_k127_1393252_27	471856.Jden_1883	1.341e-05	53.0	COG3832@1|root,COG3832@2|Bacteria	2|Bacteria	J	glyoxalase III activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF2505
HKD2_k127_1393252_20	1168059.KB899087_gene3104	7.746e-48	190.0	COG3932@1|root,COG3932@2|Bacteria,1MZD5@1224|Proteobacteria,2U77X@28211|Alphaproteobacteria,3F0WY@335928|Xanthobacteraceae	28211|Alphaproteobacteria	S	Exopolysaccharide synthesis, ExoD	exoD	-	-	-	-	-	-	-	-	-	-	-	ExoD
HKD2_k127_1393252_9	448385.sce4900	1.445e-140	453.0	COG1064@1|root,COG1064@2|Bacteria,1MUTT@1224|Proteobacteria,42MY6@68525|delta/epsilon subdivisions,2WMDC@28221|Deltaproteobacteria,2YU5V@29|Myxococcales	28221|Deltaproteobacteria	C	Alcohol dehydrogenase GroES-like domain	-	-	1.1.1.1	ko:K13953	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
HKD2_k127_1393252_18	399739.Pmen_3735	2.014e-55	213.0	COG1028@1|root,COG1028@2|Bacteria,1QTU9@1224|Proteobacteria,1RRP9@1236|Gammaproteobacteria,1YDX1@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HKD2_k127_1393252_11	358220.C380_17780	6.68e-122	399.0	COG0451@1|root,COG0451@2|Bacteria,1N8PG@1224|Proteobacteria,2VZMU@28216|Betaproteobacteria,4AGC6@80864|Comamonadaceae	28216|Betaproteobacteria	M	NAD(P)H-binding	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
HKD2_k127_1393252_14	316055.RPE_3198	4.743e-95	319.0	COG0385@1|root,COG0385@2|Bacteria,1MXF3@1224|Proteobacteria,2U2YW@28211|Alphaproteobacteria,3JYK9@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	SBF-like CPA transporter family (DUF4137)	-	-	-	ko:K03453	-	-	-	-	ko00000	2.A.28	-	-	SBF
HKD2_k127_1411405_37	342113.DM82_4729	1.893e-99	344.0	28JQB@1|root,2Z9G8@2|Bacteria,1QCH9@1224|Proteobacteria,2VJJF@28216|Betaproteobacteria,1K17Y@119060|Burkholderiaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1411405_71	1122604.JONR01000003_gene1497	2.079e-48	181.0	COG2863@1|root,COG2863@2|Bacteria,1RM00@1224|Proteobacteria,1SQEF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C
HKD2_k127_1411405_30	1122613.ATUP01000001_gene90	1.163e-125	409.0	COG0596@1|root,COG0596@2|Bacteria,1MUSF@1224|Proteobacteria,2TSK5@28211|Alphaproteobacteria,4415K@69657|Hyphomonadaceae	28211|Alphaproteobacteria	S	Serine aminopeptidase, S33	dhmA	-	3.8.1.5	ko:K01563	ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120	-	R05284,R05367,R05368,R05369,R05370,R07669,R07670	RC01317,RC01340,RC01341,RC02013	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1
HKD2_k127_1411405_9	381666.H16_A1549	1.285e-205	648.0	COG0065@1|root,COG0065@2|Bacteria,1MVYR@1224|Proteobacteria,2VHVF@28216|Betaproteobacteria,1K2IZ@119060|Burkholderiaceae	28216|Betaproteobacteria	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	-	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
HKD2_k127_1411405_33	404589.Anae109_1731	2.837e-112	370.0	COG0053@1|root,COG0053@2|Bacteria,1MUDS@1224|Proteobacteria,42NCJ@68525|delta/epsilon subdivisions,2WM7V@28221|Deltaproteobacteria,2Z1U0@29|Myxococcales	28221|Deltaproteobacteria	P	Dimerisation domain of Zinc Transporter	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,ZT_dimer
HKD2_k127_1411405_43	745310.G432_00400	1.349e-78	267.0	COG0066@1|root,COG0066@2|Bacteria,1MVXB@1224|Proteobacteria,2VEQM@28211|Alphaproteobacteria,2K45W@204457|Sphingomonadales	204457|Sphingomonadales	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	-	-	4.2.1.33,4.2.1.35	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R10170	RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase_C
HKD2_k127_1411405_13	1248760.ANFZ01000012_gene17	7.678e-177	563.0	COG1804@1|root,COG1804@2|Bacteria,1MU5U@1224|Proteobacteria,2TRIZ@28211|Alphaproteobacteria,2K1AJ@204457|Sphingomonadales	204457|Sphingomonadales	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
HKD2_k127_1411405_29	566466.NOR53_3532	3.803e-127	415.0	COG3386@1|root,COG3386@2|Bacteria,1QN8Y@1224|Proteobacteria,1S5PU@1236|Gammaproteobacteria,1J7F2@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	G	SMP-30/Gluconolaconase/LRE-like region	-	-	3.1.1.17	ko:K01053	ko00030,ko00053,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,map00030,map00053,map00930,map01100,map01110,map01120,map01130,map01200,map01220	M00129	R01519,R02933,R03751	RC00537,RC00983	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	SGL
HKD2_k127_1411405_53	1122970.AUHC01000011_gene2715	1.186e-70	247.0	COG1024@1|root,COG1024@2|Bacteria,1N4N7@1224|Proteobacteria,2TS6T@28211|Alphaproteobacteria,2K1V0@204457|Sphingomonadales	204457|Sphingomonadales	I	enoyl-CoA hydratase	-	-	4.2.1.17	ko:K01692	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
HKD2_k127_1411405_77	298386.PBPRA1243	2.418e-37	155.0	COG3187@1|root,COG3895@1|root,COG4461@1|root,COG3187@2|Bacteria,COG3895@2|Bacteria,COG4461@2|Bacteria,1PF0Q@1224|Proteobacteria,1TBDV@1236|Gammaproteobacteria,1XWBZ@135623|Vibrionales	135623|Vibrionales	O	META domain	-	-	-	-	-	-	-	-	-	-	-	-	META
HKD2_k127_1411405_41	710421.Mycch_5260	1.151e-83	297.0	COG1020@1|root,COG1020@2|Bacteria,2GMHU@201174|Actinobacteria,235KS@1762|Mycobacteriaceae	201174|Actinobacteria	I	Belongs to the long-chain O-acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	DUF1298,WES_acyltransf
HKD2_k127_1411405_25	627192.SLG_31140	3.058e-136	447.0	COG1113@1|root,COG1113@2|Bacteria,1MUPS@1224|Proteobacteria,2U0PN@28211|Alphaproteobacteria,2KD49@204457|Sphingomonadales	204457|Sphingomonadales	E	Amino acid permease	-	-	-	ko:K11735	-	-	-	-	ko00000,ko02000	2.A.3.1.4,2.A.3.1.5	-	-	AA_permease
HKD2_k127_1411405_81	1144307.PMI04_01282	1.445e-32	143.0	COG3832@1|root,COG3832@2|Bacteria,1N2PR@1224|Proteobacteria,2VGJB@28211|Alphaproteobacteria,2KE45@204457|Sphingomonadales	204457|Sphingomonadales	J	glyoxalase III activity	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
HKD2_k127_1411405_6	1121405.dsmv_1872	3.683e-219	691.0	COG0029@1|root,COG0029@2|Bacteria,1RBQW@1224|Proteobacteria,43BKD@68525|delta/epsilon subdivisions,2WJNK@28221|Deltaproteobacteria,2MIMB@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Catalyzes the oxidation of L-aspartate to iminoaspartate	nadB	-	1.4.3.16	ko:K00278	ko00250,ko00760,ko01100,map00250,map00760,map01100	M00115	R00357,R00481	RC00006,RC02566	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
HKD2_k127_1411405_19	880073.Calab_3506	1.453e-156	501.0	COG0379@1|root,COG0379@2|Bacteria,2NP47@2323|unclassified Bacteria	2|Bacteria	H	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate	nadA	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008987,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016053,GO:0017144,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0019805,GO:0030312,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0040007,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046496,GO:0046874,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0055086,GO:0071704,GO:0071944,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	2.5.1.72	ko:K03517	ko00760,ko01100,map00760,map01100	M00115	R04292	RC01119	ko00000,ko00001,ko00002,ko01000	-	-	iAF1260.b0750,iAPECO1_1312.APECO1_1338,iB21_1397.B21_00692,iBWG_1329.BWG_0602,iECBD_1354.ECBD_2917,iECB_1328.ECB_00703,iECDH10B_1368.ECDH10B_0817,iECDH1ME8569_1439.ECDH1ME8569_0703,iECD_1391.ECD_00703,iECED1_1282.ECED1_0711,iECOK1_1307.ECOK1_0750,iECP_1309.ECP_0761,iECS88_1305.ECS88_0766,iECSP_1301.ECSP_0802,iECs_1301.ECs0778,iETEC_1333.ETEC_0754,iEcDH1_1363.EcDH1_2892,iEcolC_1368.EcolC_2912,iHN637.CLJU_RS12020,iJN746.PP_1231,iJO1366.b0750,iJR904.b0750,iUMN146_1321.UM146_13905,iUTI89_1310.UTI89_C0747,iY75_1357.Y75_RS03905,iZ_1308.Z0919	NadA
HKD2_k127_1411405_76	580332.Slit_2503	3.412e-39	158.0	COG0847@1|root,COG0847@2|Bacteria,1RCPS@1224|Proteobacteria,2WEVE@28216|Betaproteobacteria,44WB3@713636|Nitrosomonadales	28216|Betaproteobacteria	L	PFAM Exonuclease RNase T and DNA polymerase III	-	-	2.7.7.7	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	RNase_T
HKD2_k127_1411405_14	62928.azo2201	3.168e-170	558.0	COG2905@1|root,COG2905@2|Bacteria,1MW8U@1224|Proteobacteria,2VHE1@28216|Betaproteobacteria,2KVCU@206389|Rhodocyclales	206389|Rhodocyclales	T	signal-transduction protein containing cAMP-binding and CBS domains	-	-	-	ko:K07182	-	-	-	-	ko00000	-	-	-	CBS,DUF294,DUF294_C,cNMP_binding
HKD2_k127_1411405_3	1122951.ATUE01000009_gene418	1.102e-278	869.0	COG4147@1|root,COG4147@2|Bacteria,1MVJ8@1224|Proteobacteria,1RN0R@1236|Gammaproteobacteria,3NJC9@468|Moraxellaceae	1236|Gammaproteobacteria	S	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	actP	-	-	ko:K14393	-	-	-	-	ko00000,ko02000	2.A.21.7	-	-	SSF
HKD2_k127_1411405_79	395494.Galf_2630	1.539e-34	151.0	COG3162@1|root,COG3162@2|Bacteria,1N9T2@1224|Proteobacteria	1224|Proteobacteria	S	Protein of unknown function, DUF485	-	-	-	-	-	-	-	-	-	-	-	-	DUF485
HKD2_k127_1411405_16	1122603.ATVI01000008_gene2465	1.477e-163	527.0	COG3268@1|root,COG3268@2|Bacteria,1MVI3@1224|Proteobacteria,1RSCK@1236|Gammaproteobacteria,1X5F5@135614|Xanthomonadales	135614|Xanthomonadales	S	Saccharopine dehydrogenase NADP binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Sacchrp_dh_NADP
HKD2_k127_1411405_69	1280944.HY17_12270	2.135e-51	189.0	COG5331@1|root,COG5331@2|Bacteria,1N0MD@1224|Proteobacteria,2U9ZR@28211|Alphaproteobacteria,43Y43@69657|Hyphomonadaceae	28211|Alphaproteobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	MAPEG
HKD2_k127_1411405_78	697282.Mettu_4100	1.866e-35	143.0	COG2068@1|root,COG2068@2|Bacteria,1MW0X@1224|Proteobacteria,1SEGZ@1236|Gammaproteobacteria,1XGGS@135618|Methylococcales	135618|Methylococcales	S	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_3
HKD2_k127_1411405_61	883126.HMPREF9710_05176	3.317e-62	222.0	COG2080@1|root,COG2080@2|Bacteria,1RD8C@1224|Proteobacteria,2VQ9M@28216|Betaproteobacteria	28216|Betaproteobacteria	C	2Fe-2S -binding domain protein	iorA	-	1.3.99.16	ko:K07302	-	-	-	-	ko00000,ko01000	-	-	-	Fer2,Fer2_2
HKD2_k127_1411405_4	395495.Lcho_1988	8.136e-264	832.0	COG1529@1|root,COG1529@2|Bacteria,1QTTJ@1224|Proteobacteria,2VHB9@28216|Betaproteobacteria,1KJ3Z@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL CutL-like protein	-	-	1.3.99.16	ko:K07303	-	-	-	-	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
HKD2_k127_1411405_88	1123367.C666_00945	1.52e-20	100.0	COG0810@1|root,COG0810@2|Bacteria,1MZPX@1224|Proteobacteria,2VM32@28216|Betaproteobacteria,2KWVW@206389|Rhodocyclales	206389|Rhodocyclales	M	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	TonB_C
HKD2_k127_1411405_56	1385517.N800_07535	1.234e-68	248.0	COG0811@1|root,COG0811@2|Bacteria,1RDJF@1224|Proteobacteria,1T1A5@1236|Gammaproteobacteria,1XD3P@135614|Xanthomonadales	135614|Xanthomonadales	U	Biopolymer transporter ExbB	-	-	-	ko:K03561	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	MotA_ExbB
HKD2_k127_1411405_75	666681.M301_2528	5.272e-40	153.0	COG0848@1|root,COG0848@2|Bacteria,1MZ6M@1224|Proteobacteria,2VSVW@28216|Betaproteobacteria,2KN0J@206350|Nitrosomonadales	206350|Nitrosomonadales	U	PFAM Biopolymer transport protein ExbD TolR	-	-	-	ko:K03559	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	ExbD
HKD2_k127_1411405_80	1535422.ND16A_2142	6.213e-34	138.0	COG3339@1|root,COG3339@2|Bacteria,1RAN7@1224|Proteobacteria,1S291@1236|Gammaproteobacteria,2Q6RN@267889|Colwelliaceae	1236|Gammaproteobacteria	S	Protein of unknown function (DUF1232)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1232
HKD2_k127_1411405_55	1223410.KN050846_gene2424	5.17e-69	245.0	COG2964@1|root,COG2964@2|Bacteria	2|Bacteria	S	HTH domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HTH_22,HisKA,PAS_3,PAS_6,PAS_9
HKD2_k127_1411405_48	1510531.JQJJ01000008_gene3889	1.308e-75	260.0	COG0235@1|root,COG0235@2|Bacteria,1MW7B@1224|Proteobacteria,2U1NG@28211|Alphaproteobacteria,3JUW4@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Class II Aldolase and Adducin N-terminal domain	fucA	-	4.1.2.17	ko:K01628	ko00051,ko01120,map00051,map01120	-	R02262	RC00603,RC00604	ko00000,ko00001,ko01000	-	-	-	Aldolase_II
HKD2_k127_1411405_18	426355.Mrad2831_4121	2.69e-158	507.0	COG0182@1|root,COG0182@2|Bacteria,1MUPM@1224|Proteobacteria,2TSPP@28211|Alphaproteobacteria,1JS0Z@119045|Methylobacteriaceae	28211|Alphaproteobacteria	J	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)	mtnA	-	5.3.1.23	ko:K08963	ko00270,ko01100,map00270,map01100	M00034	R04420	RC01151	ko00000,ko00001,ko00002,ko01000	-	-	-	IF-2B
HKD2_k127_1411405_23	1411123.JQNH01000001_gene2252	1.126e-140	451.0	COG0005@1|root,COG0005@2|Bacteria,1MUWW@1224|Proteobacteria,2TSN3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	F	Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates	mtnP	-	2.4.2.28	ko:K00772	ko00270,ko01100,map00270,map01100	M00034	R01402	RC00063,RC02819	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
HKD2_k127_1411405_50	402881.Plav_2409	6.866e-73	256.0	COG0697@1|root,COG0697@2|Bacteria,1MVKG@1224|Proteobacteria,2U30N@28211|Alphaproteobacteria,1JQ41@119043|Rhodobiaceae	28211|Alphaproteobacteria	EG	EamA-like transporter family	-	-	-	ko:K15268	-	-	-	-	ko00000,ko02000	2.A.7.3.2	-	-	EamA
HKD2_k127_1411405_54	1266925.JHVX01000003_gene391	1.595e-70	248.0	COG1028@1|root,COG1028@2|Bacteria,1RHYX@1224|Proteobacteria,2VR0S@28216|Betaproteobacteria,372JA@32003|Nitrosomonadales	28216|Betaproteobacteria	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HKD2_k127_1411405_57	1215092.PA6_040_00330	2.494e-67	233.0	COG0346@1|root,COG0346@2|Bacteria,1RCYX@1224|Proteobacteria,1S1Z9@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione	gloA	-	4.4.1.5	ko:K01759	ko00620,map00620	-	R02530	RC00004,RC00740	ko00000,ko00001,ko01000	-	-	-	Glyoxalase
HKD2_k127_1411405_92	1121943.KB899992_gene2349	1.657e-11	72.0	COG0558@1|root,COG0558@2|Bacteria,1RCZ7@1224|Proteobacteria,1S465@1236|Gammaproteobacteria,1XJF2@135619|Oceanospirillales	135619|Oceanospirillales	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pgsA	-	2.7.8.41,2.7.8.5	ko:K00995,ko:K08744	ko00564,ko01100,map00564,map01100	-	R01801,R02030	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
HKD2_k127_1411405_59	68260.JOAY01000020_gene1611	3.167e-65	246.0	COG0075@1|root,COG0075@2|Bacteria,2GM5F@201174|Actinobacteria	201174|Actinobacteria	E	Aminotransferase	-	-	2.6.1.37	ko:K03430	ko00440,ko01100,ko01120,map00440,map01100,map01120	-	R04152	RC00008,RC00062	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_5
HKD2_k127_1411405_68	247634.GPB2148_2279	8.697e-53	192.0	COG1267@1|root,COG1267@2|Bacteria,1MZJA@1224|Proteobacteria,1S68A@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)	pgpA	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006629,GO:0006644,GO:0006650,GO:0006655,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0008962,GO:0009058,GO:0009987,GO:0010035,GO:0010038,GO:0016020,GO:0016021,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019637,GO:0030258,GO:0031224,GO:0031226,GO:0032026,GO:0042221,GO:0042577,GO:0042578,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044425,GO:0044459,GO:0044464,GO:0045017,GO:0046471,GO:0046474,GO:0046486,GO:0046839,GO:0050896,GO:0071704,GO:0071944,GO:0090407,GO:1901576	3.1.3.27	ko:K01095	ko00564,ko01100,map00564,map01100	-	R02029	RC00017	ko00000,ko00001,ko01000	-	-	iECSP_1301.ECSP_0485,iECUMN_1333.ECUMN_0456,iECs_1301.ECs0471,iG2583_1286.G2583_0529,iPC815.YPO3179,iZ_1308.Z0520	PgpA
HKD2_k127_1411405_27	1242864.D187_008484	9.254e-131	431.0	COG2843@1|root,COG2843@2|Bacteria,1P1MG@1224|Proteobacteria,42MEY@68525|delta/epsilon subdivisions,2WM0F@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Bacterial capsule synthesis protein PGA_cap	-	-	-	ko:K07282	-	-	-	-	ko00000	-	-	-	PGA_cap
HKD2_k127_1411405_5	1283300.ATXB01000001_gene1705	1.11e-221	701.0	COG1387@1|root,COG1387@2|Bacteria,1MYXV@1224|Proteobacteria,1SZW9@1236|Gammaproteobacteria,1XFPE@135618|Methylococcales	135618|Methylococcales	L	DNA polymerase X family	-	-	-	ko:K02347	-	-	-	-	ko00000,ko03400	-	-	-	DNA_pol_B_palm,DNA_pol_B_thumb,HHH_5,HHH_8,PHP
HKD2_k127_1411405_12	290397.Adeh_2271	1.165e-187	602.0	28IJB@1|root,2Z8K8@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1411405_21	926550.CLDAP_16780	4.42e-143	469.0	COG5598@1|root,COG5598@2|Bacteria	2|Bacteria	H	trimethylamine methyltransferase	-	-	2.1.1.250	ko:K14083	ko00680,ko01120,ko01200,map00680,map01120,map01200	M00563	R09124,R10016	RC00035,RC00732,RC01144,RC02984	ko00000,ko00001,ko00002,ko01000	-	-	-	MTTB
HKD2_k127_1411405_66	626887.J057_04341	3.08e-55	207.0	2DKFZ@1|root,309D6@2|Bacteria,1REQQ@1224|Proteobacteria,1S796@1236|Gammaproteobacteria,466PI@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Domain of unknown function (DUF4382)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4382
HKD2_k127_1411405_40	1384056.N787_06465	1.572e-91	318.0	COG1404@1|root,COG1404@2|Bacteria,1MU3S@1224|Proteobacteria,1RQ7X@1236|Gammaproteobacteria,1X4WC@135614|Xanthomonadales	135614|Xanthomonadales	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
HKD2_k127_1411405_73	360094.PXO_00666	1.2e-47	177.0	COG1595@1|root,COG1595@2|Bacteria,1MZMC@1224|Proteobacteria,1S4SX@1236|Gammaproteobacteria,1X776@135614|Xanthomonadales	135614|Xanthomonadales	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD2_k127_1411405_85	366602.Caul_4269	1.063e-26	121.0	COG5662@1|root,COG5662@2|Bacteria,1N1PB@1224|Proteobacteria,2VGMS@28211|Alphaproteobacteria,2KH75@204458|Caulobacterales	204458|Caulobacterales	K	AntiSigma factor	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1411405_11	1449126.JQKL01000057_gene2257	8.579e-201	640.0	COG2759@1|root,COG2759@2|Bacteria,1TP6N@1239|Firmicutes,247P5@186801|Clostridia,267QX@186813|unclassified Clostridiales	186801|Clostridia	F	Formate--tetrahydrofolate ligase	fhs	-	6.3.4.3	ko:K01938	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R00943	RC00026,RC00111	ko00000,ko00001,ko00002,ko01000	-	-	-	FTHFS
HKD2_k127_1411405_1	595494.Tola_1844	0.0	1054.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,1RMYC@1236|Gammaproteobacteria,1Y59U@135624|Aeromonadales	135624|Aeromonadales	P	Cation transporter/ATPase, N-terminus	mgtA	-	3.6.3.2	ko:K01531	-	-	-	-	ko00000,ko01000	3.A.3.4	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
HKD2_k127_1411405_31	314285.KT71_06379	2.06e-123	410.0	COG2271@1|root,COG2271@2|Bacteria,1MVPS@1224|Proteobacteria,1RNMV@1236|Gammaproteobacteria,1JAD2@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	G	COG0477 Permeases of the major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD2_k127_1411405_82	397945.Aave_0127	3.915e-32	135.0	COG1853@1|root,COG1853@2|Bacteria,1RGYM@1224|Proteobacteria,2VQA1@28216|Betaproteobacteria,4ADNK@80864|Comamonadaceae	28216|Betaproteobacteria	S	PFAM flavin reductase domain protein, FMN-binding	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
HKD2_k127_1411405_35	1366050.N234_25495	4.985e-103	348.0	COG1960@1|root,COG1960@2|Bacteria,1MW97@1224|Proteobacteria,2W1EE@28216|Betaproteobacteria,1KHM8@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_2,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HKD2_k127_1411405_36	670307.HYPDE_39243	1.359e-99	335.0	COG2207@1|root,COG2207@2|Bacteria,1N0FA@1224|Proteobacteria,2TW52@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	transcriptional regulator, AraC family	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_6,HTH_18
HKD2_k127_1411405_17	186497.PF0547	1.22e-158	513.0	COG2403@1|root,arCOG01229@2157|Archaea,2XVYH@28890|Euryarchaeota,24343@183968|Thermococci	183968|Thermococci	S	CobW/HypB/UreG, nucleotide-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	cobW
HKD2_k127_1411405_10	1192034.CAP_7111	1.489e-203	654.0	2BRHU@1|root,32KGU@2|Bacteria,1Q2UP@1224|Proteobacteria,438H4@68525|delta/epsilon subdivisions,2X3RX@28221|Deltaproteobacteria,2YWYJ@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1411405_58	748280.NH8B_3033	6.349e-67	234.0	COG5588@1|root,COG5588@2|Bacteria,1RGIE@1224|Proteobacteria,2VNWW@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Protein of unknown function (DUF1326)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1326
HKD2_k127_1411405_70	211165.AJLN01000120_gene770	7.95e-50	186.0	COG5486@1|root,COG5486@2|Bacteria,1GF5E@1117|Cyanobacteria	1117|Cyanobacteria	S	Predicted metal-binding integral membrane protein (DUF2182)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2182
HKD2_k127_1411405_38	450851.PHZ_c1372	1.732e-98	334.0	COG3000@1|root,COG3000@2|Bacteria,1NR7X@1224|Proteobacteria,2TT68@28211|Alphaproteobacteria,2KG0P@204458|Caulobacterales	204458|Caulobacterales	I	Fatty acid hydroxylase	-	-	-	-	-	-	-	-	-	-	-	-	FA_hydroxylase
HKD2_k127_1411405_86	927677.ALVU02000001_gene3540	1.279e-22	109.0	COG0317@1|root,COG0317@2|Bacteria,1GEK3@1117|Cyanobacteria	1117|Cyanobacteria	KT	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	HD_4
HKD2_k127_1411405_46	1535287.JP74_08615	4.315e-76	268.0	COG1414@1|root,COG3386@1|root,COG1414@2|Bacteria,COG3386@2|Bacteria,1MUNW@1224|Proteobacteria,2TSY8@28211|Alphaproteobacteria,3N8Q8@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	helix_turn_helix isocitrate lyase regulation	-	-	-	ko:K13641	-	-	-	-	ko00000,ko03000	-	-	-	HTH_IclR,IclR,SGL
HKD2_k127_1411405_62	981384.AEYW01000001_gene1463	5.818e-60	220.0	COG0451@1|root,COG0451@2|Bacteria,1R9YI@1224|Proteobacteria,2U5Z5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	GM	NAD dependent epimerase/dehydratase family	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
HKD2_k127_1411405_51	671143.DAMO_2979	9.492e-72	259.0	COG1216@1|root,COG1216@2|Bacteria	2|Bacteria	V	Glycosyl transferase, family 2	-	-	-	-	-	-	-	-	-	-	-	-	DUF616,Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_2,Glyphos_transf,NTP_transf_5
HKD2_k127_1411405_67	671143.DAMO_2980	6.471e-55	200.0	COG1216@1|root,COG1216@2|Bacteria,2NP6P@2323|unclassified Bacteria	2|Bacteria	S	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HKD2_k127_1411405_60	671143.DAMO_2980	1.219e-62	228.0	COG1216@1|root,COG1216@2|Bacteria,2NP6P@2323|unclassified Bacteria	2|Bacteria	S	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HKD2_k127_1411405_63	671143.DAMO_2981	1.614e-59	224.0	COG1493@1|root,COG1493@2|Bacteria	2|Bacteria	T	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion	-	-	-	-	-	-	-	-	-	-	-	-	DRTGG
HKD2_k127_1411405_87	13689.BV96_01707	1.604e-21	108.0	2E53J@1|root,32ZWN@2|Bacteria,1R99Z@1224|Proteobacteria,2U45T@28211|Alphaproteobacteria,2K9N9@204457|Sphingomonadales	204457|Sphingomonadales	S	Uncharacterised nucleotidyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_5
HKD2_k127_1411405_90	1128421.JAGA01000002_gene757	5.809e-15	88.0	COG2244@1|root,COG2244@2|Bacteria,2NPWA@2323|unclassified Bacteria	2|Bacteria	S	Polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt,Polysacc_synt_3,Polysacc_synt_C
HKD2_k127_1411405_24	1385517.N800_12900	6.524e-138	455.0	COG3118@1|root,COG3118@2|Bacteria,1QWQK@1224|Proteobacteria,1T5NR@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	Sulfotransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_3
HKD2_k127_1411405_7	722419.PH505_bc00130	6.023e-216	696.0	COG4773@1|root,COG4773@2|Bacteria,1QURT@1224|Proteobacteria,1SM3F@1236|Gammaproteobacteria,2PZVJ@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	M	COG1629 Outer membrane receptor proteins, mostly Fe transport	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
HKD2_k127_1411405_52	266265.Bxe_A2150	1.867e-71	254.0	COG1975@1|root,COG3350@1|root,COG1975@2|Bacteria,COG3350@2|Bacteria,1MWFN@1224|Proteobacteria,2W9ND@28216|Betaproteobacteria,1K1U8@119060|Burkholderiaceae	28216|Betaproteobacteria	O	YHS domain	-	-	-	ko:K07402	-	-	-	-	ko00000	-	-	-	XdhC_C,XdhC_CoxI,YHS
HKD2_k127_1411405_32	266265.Bxe_A2149	4.085e-116	394.0	COG3552@1|root,COG3552@2|Bacteria,1MUHH@1224|Proteobacteria,2VNH5@28216|Betaproteobacteria,1K1YF@119060|Burkholderiaceae	28216|Betaproteobacteria	S	VWA domain containing CoxE-like protein	-	-	-	-	-	-	-	-	-	-	-	-	VWA_CoxE
HKD2_k127_1411405_28	196367.JNFG01000011_gene6090	2.435e-127	417.0	COG0714@1|root,COG0714@2|Bacteria,1MV5I@1224|Proteobacteria,2VIJR@28216|Betaproteobacteria,1K34U@119060|Burkholderiaceae	28216|Betaproteobacteria	S	AAA domain (dynein-related subfamily)	-	-	-	-	-	-	-	-	-	-	-	-	AAA_5
HKD2_k127_1411405_65	266265.Bxe_A2147	3.23e-58	211.0	COG3427@1|root,COG3427@2|Bacteria,1N4EQ@1224|Proteobacteria,2W4Q9@28216|Betaproteobacteria,1K52T@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Carbon monoxide dehydrogenase subunit G (CoxG)	-	-	-	ko:K09386	-	-	-	-	ko00000	-	-	-	COXG
HKD2_k127_1411405_0	1123228.AUIH01000004_gene1091	0.0	1242.0	COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,1RN40@1236|Gammaproteobacteria,1XRUQ@135619|Oceanospirillales	135619|Oceanospirillales	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	1.17.1.4,1.3.99.8	ko:K11177,ko:K16877	ko00230,ko00365,ko01100,ko01120,map00230,map00365,map01100,map01120	M00546	R01768,R02103,R02987	RC00143,RC01856	ko00000,ko00001,ko00002,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2,Fer2_2
HKD2_k127_1411405_42	266265.Bxe_A2145	4.826e-82	275.0	COG2080@1|root,COG2080@2|Bacteria,1RD8C@1224|Proteobacteria,2VQ75@28216|Betaproteobacteria,1K322@119060|Burkholderiaceae	28216|Betaproteobacteria	C	[2Fe-2S] binding domain	-	-	1.2.5.3	ko:K03518	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Fer2,Fer2_2
HKD2_k127_1411405_26	266265.Bxe_A2144	3.222e-131	428.0	COG1319@1|root,COG1319@2|Bacteria,1MUDB@1224|Proteobacteria,2VSFQ@28216|Betaproteobacteria,1K13T@119060|Burkholderiaceae	28216|Betaproteobacteria	C	CO dehydrogenase flavoprotein C-terminal domain	-	-	1.2.5.3	ko:K03519	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
HKD2_k127_1411405_64	1100721.ALKO01000018_gene1169	7.536e-59	212.0	COG2068@1|root,COG2068@2|Bacteria,1MW0X@1224|Proteobacteria,2VT4G@28216|Betaproteobacteria,4AERD@80864|Comamonadaceae	28216|Betaproteobacteria	S	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	-	-	1.1.1.328,2.7.7.76	ko:K07141,ko:K19190	ko00760,ko00790,ko01120,map00760,map00790,map01120	-	R10131,R10132,R11582	RC03053	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
HKD2_k127_1411405_34	1123228.AUIH01000004_gene1085	3.903e-107	354.0	COG1975@1|root,COG1975@2|Bacteria,1MWFN@1224|Proteobacteria,1RV4F@1236|Gammaproteobacteria,1XQ7H@135619|Oceanospirillales	135619|Oceanospirillales	O	XdhC Rossmann domain	-	-	-	-	-	-	-	-	-	-	-	-	XdhC_C,XdhC_CoxI
HKD2_k127_1411405_47	566466.NOR53_477	9.529e-76	278.0	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1RWT6@1236|Gammaproteobacteria,1J7Y7@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1411405_83	713586.KB900536_gene2262	1.824e-30	124.0	2C3CF@1|root,32RRR@2|Bacteria,1MZUG@1224|Proteobacteria,1SFHW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function (DUF3175)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3175
HKD2_k127_1411405_72	56780.SYN_00659	1.136e-47	186.0	COG0834@1|root,COG1073@1|root,COG0834@2|Bacteria,COG1073@2|Bacteria,1N3ZN@1224|Proteobacteria,42VWV@68525|delta/epsilon subdivisions	1224|Proteobacteria	ET	Cache domain	-	-	-	-	-	-	-	-	-	-	-	-	dCache_1
HKD2_k127_1411405_49	1333856.L686_17940	2.039e-75	255.0	COG0590@1|root,COG0590@2|Bacteria,1RE8P@1224|Proteobacteria,1S3V3@1236|Gammaproteobacteria,1Z2V2@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	FJ	MafB19-like deaminase	cdd	-	3.5.4.1	ko:K01485	ko00240,ko00330,ko01100,map00240,map00330,map01100	-	R00974,R01411,R02922	RC00074,RC00514,RC00809	ko00000,ko00001,ko01000	-	-	-	dCMP_cyt_deam_1
HKD2_k127_1411405_93	468059.AUHA01000003_gene1550	1.929e-06	56.0	COG1917@1|root,COG1917@2|Bacteria	2|Bacteria	L	Cupin 2, conserved barrel domain protein	-	-	-	ko:K21700	-	-	-	-	ko00000	-	-	-	Cupin_2
HKD2_k127_1411405_74	713586.KB900536_gene319	4.53e-40	166.0	COG5305@1|root,COG5305@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HKD2_k127_1411405_39	1121875.KB907549_gene1715	1.016e-97	345.0	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,4NFW7@976|Bacteroidetes,1HZQR@117743|Flavobacteriia	976|Bacteroidetes	K	COGs COG5616 integral membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18,TPR_8
HKD2_k127_1411405_22	1286093.C266_24543	4.172e-141	456.0	COG0709@1|root,COG0709@2|Bacteria,1MWFG@1224|Proteobacteria,2VJSD@28216|Betaproteobacteria,1K0WI@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Synthesizes selenophosphate from selenide and ATP	selD	-	2.7.9.3	ko:K01008	ko00450,ko01100,map00450,map01100	-	R03595	RC00002,RC02878	ko00000,ko00001,ko01000,ko03016	-	-	-	AIRS,AIRS_C
HKD2_k127_1411405_8	1038869.AXAN01000034_gene6698	5.003e-206	674.0	COG3276@1|root,COG3276@2|Bacteria,1MWXH@1224|Proteobacteria,2VH0U@28216|Betaproteobacteria,1K27C@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Translation Elongation Factor	selB	-	-	ko:K03833	-	-	-	-	ko00000,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,SelB-wing_2,SelB-wing_3
HKD2_k127_1411405_20	987059.RBXJA2T_07235	3.553e-156	505.0	COG1921@1|root,COG1921@2|Bacteria,1MWXI@1224|Proteobacteria,2VHXE@28216|Betaproteobacteria	28216|Betaproteobacteria	H	Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis	selA	-	2.9.1.1	ko:K01042	ko00450,ko00970,map00450,map00970	-	R08219	RC01246	ko00000,ko00001,ko01000	-	-	-	Se-cys_synth_N,SelA
HKD2_k127_1411405_45	1216976.AX27061_0349	9.642e-77	269.0	COG3058@1|root,COG3058@2|Bacteria,1NK06@1224|Proteobacteria,2VJ30@28216|Betaproteobacteria,3T1XG@506|Alcaligenaceae	28216|Betaproteobacteria	O	Necessary for formate dehydrogenase activity	fdhE	-	-	ko:K02380	-	-	-	-	ko00000	-	-	-	FdhE
HKD2_k127_1411405_44	1192124.LIG30_1921	2.673e-78	268.0	COG2864@1|root,COG2864@2|Bacteria,1MXFQ@1224|Proteobacteria,2VQ99@28216|Betaproteobacteria,1KGZD@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Formate dehydrogenase gamma subunit	fdoI	-	-	ko:K00127	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001	-	-	-	Ni_hydr_CYTB
HKD2_k127_1411405_15	1123354.AUDR01000012_gene1807	4.006e-165	522.0	COG0437@1|root,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,2VHPC@28216|Betaproteobacteria,1KRHB@119069|Hydrogenophilales	119069|Hydrogenophilales	C	Formate dehydrogenase N, transmembrane	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_11,Fer4_7,Form-deh_trans
HKD2_k127_1411405_2	1156919.QWC_27282	1.581e-314	968.0	COG0243@1|root,COG3383@1|root,COG0243@2|Bacteria,COG3383@2|Bacteria,1MW3N@1224|Proteobacteria,2VJG2@28216|Betaproteobacteria,3T20K@506|Alcaligenaceae	28216|Betaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	fdnG	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
HKD2_k127_1413509_1	360910.BAV3142	2.166e-173	546.0	COG0243@1|root,COG3383@1|root,COG0243@2|Bacteria,COG3383@2|Bacteria,1MW3N@1224|Proteobacteria,2VJG2@28216|Betaproteobacteria,3T20K@506|Alcaligenaceae	28216|Betaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	fdnG	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
HKD2_k127_1413509_4	1123073.KB899241_gene2928	2.007e-105	345.0	COG0243@1|root,COG0243@2|Bacteria,1NS3T@1224|Proteobacteria,1RMWN@1236|Gammaproteobacteria,1X44A@135614|Xanthomonadales	1236|Gammaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
HKD2_k127_1413509_2	1300345.LF41_2649	5.343e-146	484.0	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1S1MS@1236|Gammaproteobacteria,1X9I0@135614|Xanthomonadales	135614|Xanthomonadales	T	Adenylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1413509_6	323848.Nmul_A2158	5.694e-91	311.0	COG0430@1|root,COG0430@2|Bacteria,1MX7Q@1224|Proteobacteria,2VHYS@28216|Betaproteobacteria,373YE@32003|Nitrosomonadales	28216|Betaproteobacteria	A	Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP	rtcA	-	6.5.1.4	ko:K01974	-	-	-	-	ko00000,ko01000	-	-	-	RTC,RTC_insert
HKD2_k127_1413509_7	622637.KE124774_gene585	5.198e-60	211.0	2AH4X@1|root,317EK@2|Bacteria,1RHUE@1224|Proteobacteria,2UADH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1413509_8	395494.Galf_0852	4.22e-28	120.0	2CM31@1|root,32SD0@2|Bacteria,1N2TZ@1224|Proteobacteria,2VUNK@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1413509_3	991905.SL003B_1031	1.025e-114	382.0	COG0845@1|root,COG0845@2|Bacteria,1Q112@1224|Proteobacteria,2V906@28211|Alphaproteobacteria,4BSRF@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	HlyD_3
HKD2_k127_1413509_0	991905.SL003B_1030	7.25e-279	880.0	COG0577@1|root,COG0577@2|Bacteria,1MW6D@1224|Proteobacteria,2TTJZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	V	COG0577 ABC-type antimicrobial peptide transport system permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HKD2_k127_1413509_5	404589.Anae109_2961	4.887e-103	340.0	COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,42P6Q@68525|delta/epsilon subdivisions,2WKPS@28221|Deltaproteobacteria,2YXDB@29|Myxococcales	28221|Deltaproteobacteria	P	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD2_k127_1416019_13	1101195.Meth11DRAFT_1311	4.301e-20	97.0	COG2230@1|root,COG2230@2|Bacteria,1MX3U@1224|Proteobacteria,2VIPR@28216|Betaproteobacteria,2KKYZ@206350|Nitrosomonadales	206350|Nitrosomonadales	M	Mycolic acid cyclopropane synthetase	-	-	2.1.1.79	ko:K00574	-	-	-	-	ko00000,ko01000	-	-	-	CMAS
HKD2_k127_1416019_6	887062.HGR_05454	1.093e-98	331.0	COG3496@1|root,COG3496@2|Bacteria,1RC56@1224|Proteobacteria,2VIZ9@28216|Betaproteobacteria,4AARP@80864|Comamonadaceae	28216|Betaproteobacteria	S	Protein of unknown function (DUF1365)	-	-	-	ko:K09701	-	-	-	-	ko00000	-	-	-	DUF1365
HKD2_k127_1416019_1	1458275.AZ34_07530	1.325e-182	588.0	COG2907@1|root,COG2907@2|Bacteria,1MV4Z@1224|Proteobacteria,2VHCR@28216|Betaproteobacteria,4AAI7@80864|Comamonadaceae	28216|Betaproteobacteria	S	FAD dependent oxidoreductase	-	-	-	ko:K06954	-	-	-	-	ko00000	-	-	-	Amino_oxidase
HKD2_k127_1416019_4	1458275.AZ34_07535	2.263e-133	431.0	COG1398@1|root,COG1398@2|Bacteria,1N2MA@1224|Proteobacteria,2VMFC@28216|Betaproteobacteria,4AFKG@80864|Comamonadaceae	28216|Betaproteobacteria	I	Fatty acid desaturase	-	-	1.14.19.1	ko:K00507	ko01040,ko01212,ko03320,ko04152,ko04212,map01040,map01212,map03320,map04152,map04212	-	R02222	RC00917	ko00000,ko00001,ko01000,ko01004	-	-	-	FA_desaturase
HKD2_k127_1416019_9	1458275.AZ34_07540	1.258e-67	247.0	COG3040@1|root,COG3040@2|Bacteria,1RIKA@1224|Proteobacteria,2VTSY@28216|Betaproteobacteria,4AJFE@80864|Comamonadaceae	28216|Betaproteobacteria	M	Lipocalin-like domain	-	-	-	ko:K03098	-	-	-	-	ko00000,ko04147	-	-	-	Lipocalin_2
HKD2_k127_1416019_8	1458275.AZ34_07550	3.648e-84	306.0	COG3752@1|root,COG3752@2|Bacteria,1MXCP@1224|Proteobacteria,2VQHY@28216|Betaproteobacteria,4ADH5@80864|Comamonadaceae	28216|Betaproteobacteria	S	3-oxo-5-alpha-steroid 4-dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	DUF1295
HKD2_k127_1416019_3	887062.HGR_05419	1.852e-151	493.0	COG2230@1|root,COG2230@2|Bacteria,1MUW5@1224|Proteobacteria,2VI5F@28216|Betaproteobacteria,4ACT9@80864|Comamonadaceae	28216|Betaproteobacteria	M	Mycolic acid cyclopropane synthetase	-	-	2.1.1.79	ko:K00574	-	-	-	-	ko00000,ko01000	-	-	-	CMAS
HKD2_k127_1416019_7	1458275.AZ34_07565	8.194e-87	297.0	COG0789@1|root,COG0789@2|Bacteria,1R2NF@1224|Proteobacteria,2VJDG@28216|Betaproteobacteria,4ACBQ@80864|Comamonadaceae	28216|Betaproteobacteria	K	PFAM regulatory protein, MerR	-	-	-	ko:K22491	-	-	-	-	ko00000,ko03000	-	-	-	B12-binding,B12-binding_2,MerR_1
HKD2_k127_1416019_12	883.DvMF_0050	4.822e-24	108.0	COG0724@1|root,COG0724@2|Bacteria,1N0P8@1224|Proteobacteria,43B6G@68525|delta/epsilon subdivisions,2WQ1E@28221|Deltaproteobacteria,2MH3Y@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	PFAM RNP-1 like RNA-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	RRM_1
HKD2_k127_1416019_11	1003200.AXXA_03939	1.504e-33	135.0	COG0361@1|root,COG0361@2|Bacteria,1MZFU@1224|Proteobacteria,2VU4I@28216|Betaproteobacteria,3T4E3@506|Alcaligenaceae	28216|Betaproteobacteria	J	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex	infA2	-	-	ko:K02518	-	-	-	-	ko00000,ko03012	-	-	-	eIF-1a
HKD2_k127_1416019_10	1510531.JQJJ01000008_gene3788	7.167e-50	181.0	COG1671@1|root,COG1671@2|Bacteria,1RCZA@1224|Proteobacteria,2U997@28211|Alphaproteobacteria,3JV5Z@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Belongs to the UPF0178 family	MA20_27470	-	-	ko:K09768	-	-	-	-	ko00000	-	-	-	DUF188
HKD2_k127_1416019_2	1300345.LF41_2649	7.765e-165	540.0	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1S1MS@1236|Gammaproteobacteria,1X9I0@135614|Xanthomonadales	135614|Xanthomonadales	T	Adenylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1416019_5	1267535.KB906767_gene1984	3.963e-119	389.0	COG0500@1|root,COG2226@2|Bacteria,3Y4HC@57723|Acidobacteria	57723|Acidobacteria	Q	Hypothetical methyltransferase	-	-	2.1.1.137	ko:K07755	-	-	-	-	ko00000,ko01000	-	-	-	Methyltransf_31
HKD2_k127_1416019_0	314265.R2601_20154	3.951e-248	777.0	COG1574@1|root,COG1574@2|Bacteria,1MWP2@1224|Proteobacteria,2TXAW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	metal-dependent hydrolase with the TIM-barrel fold	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
HKD2_k127_1418119_3	543913.D521_0301	5.05e-34	134.0	COG3686@1|root,COG3686@2|Bacteria,1N8EA@1224|Proteobacteria,2VSWW@28216|Betaproteobacteria	28216|Betaproteobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	MAPEG
HKD2_k127_1418119_1	1121015.N789_12830	9.794e-79	275.0	COG3000@1|root,COG3000@2|Bacteria,1R4RM@1224|Proteobacteria,1SAME@1236|Gammaproteobacteria,1XA9M@135614|Xanthomonadales	135614|Xanthomonadales	I	sterol desaturase	-	-	-	-	-	-	-	-	-	-	-	-	FA_hydroxylase
HKD2_k127_1418119_0	1122603.ATVI01000006_gene434	4.116e-108	359.0	COG2962@1|root,COG2962@2|Bacteria,1MX5G@1224|Proteobacteria,1RMAC@1236|Gammaproteobacteria,1X3PF@135614|Xanthomonadales	135614|Xanthomonadales	S	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HKD2_k127_1418119_2	264198.Reut_A3458	3.216e-40	157.0	COG2050@1|root,COG2050@2|Bacteria,1RGXI@1224|Proteobacteria	1224|Proteobacteria	Q	Thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
HKD2_k127_1418119_4	977880.RALTA_B0939	9.145e-15	76.0	COG1881@1|root,COG1881@2|Bacteria,1N0Y4@1224|Proteobacteria,2VR39@28216|Betaproteobacteria,1K5JG@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Phosphatidylethanolamine-binding protein	-	-	-	ko:K06910	-	-	-	-	ko00000	-	-	-	PBP
HKD2_k127_1513911_0	765912.Thimo_2452	0.0	1631.0	COG0046@1|root,COG0047@1|root,COG0046@2|Bacteria,COG0047@2|Bacteria,1MYN4@1224|Proteobacteria,1RMRN@1236|Gammaproteobacteria,1WX8F@135613|Chromatiales	135613|Chromatiales	F	Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS_C,GATase_5
HKD2_k127_1513911_21	1122194.AUHU01000002_gene2749	2.703e-22	104.0	290UJ@1|root,2ZNGJ@2|Bacteria,1RBSP@1224|Proteobacteria,1S3RZ@1236|Gammaproteobacteria,4675M@72275|Alteromonadaceae	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1513911_8	1122604.JONR01000025_gene4545	5.857e-137	456.0	COG2986@1|root,COG2986@2|Bacteria,1MU6K@1224|Proteobacteria,1RP02@1236|Gammaproteobacteria,1X39J@135614|Xanthomonadales	135614|Xanthomonadales	E	Histidine ammonia-lyase	hutH	-	4.3.1.3	ko:K01745	ko00340,ko01100,map00340,map01100	M00045	R01168	RC00361	ko00000,ko00001,ko00002,ko01000	-	-	-	Lyase_aromatic
HKD2_k127_1513911_3	572477.Alvin_0632	8.702e-295	913.0	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,1RPWS@1236|Gammaproteobacteria,1WWTW@135613|Chromatiales	135613|Chromatiales	S	ABC transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,ABC_tran_Xtn
HKD2_k127_1513911_5	314278.NB231_10088	1.284e-208	656.0	COG0112@1|root,COG0112@2|Bacteria,1MUIS@1224|Proteobacteria,1RMHQ@1236|Gammaproteobacteria,1WW0I@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
HKD2_k127_1513911_18	1177181.T9A_00600	2.738e-67	233.0	COG1327@1|root,COG1327@2|Bacteria,1RE7V@1224|Proteobacteria,1S3P9@1236|Gammaproteobacteria,1XJKR@135619|Oceanospirillales	135619|Oceanospirillales	K	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes	nrdR	-	-	ko:K07738	-	-	-	-	ko00000,ko03000	-	-	-	ATP-cone
HKD2_k127_1513911_10	393595.ABO_2174	2.052e-115	384.0	COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,1MUWT@1224|Proteobacteria,1RN2M@1236|Gammaproteobacteria,1XIAX@135619|Oceanospirillales	135619|Oceanospirillales	H	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate	ribD	-	1.1.1.193,3.5.4.26	ko:K11752	ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024	M00125	R03458,R03459	RC00204,RC00933	ko00000,ko00001,ko00002,ko01000	-	-	-	RibD_C,dCMP_cyt_deam_1
HKD2_k127_1513911_17	572477.Alvin_1770	6.272e-73	251.0	COG0307@1|root,COG0307@2|Bacteria,1MUMB@1224|Proteobacteria,1RMSY@1236|Gammaproteobacteria,1WXA6@135613|Chromatiales	135613|Chromatiales	H	riboflavin synthase, alpha subunit	-	-	2.5.1.9	ko:K00793	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00066	RC00958,RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	Lum_binding
HKD2_k127_1513911_7	1415780.JPOG01000001_gene894	1.132e-150	484.0	COG0108@1|root,COG0108@2|Bacteria,1MU8P@1224|Proteobacteria,1RQ49@1236|Gammaproteobacteria,1X31N@135614|Xanthomonadales	135614|Xanthomonadales	H	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate	ribB	-	3.5.4.25,4.1.99.12	ko:K14652	ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110	M00125,M00840	R00425,R07281	RC00293,RC01792,RC01815,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	-	DHBP_synthase,GTP_cyclohydro2
HKD2_k127_1513911_19	83406.HDN1F_25430	8.74e-55	196.0	COG0054@1|root,COG0054@2|Bacteria,1RD9J@1224|Proteobacteria,1S3WD@1236|Gammaproteobacteria,1J5Y6@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	H	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin	ribH	GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.78	ko:K00794	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R04457	RC00960	ko00000,ko00001,ko00002,ko01000	-	-	iSFV_1184.SFV_0380	DMRL_synthase
HKD2_k127_1513911_20	1121013.P873_03270	3.364e-32	141.0	COG0781@1|root,COG0781@2|Bacteria,1RHFZ@1224|Proteobacteria,1S6AJ@1236|Gammaproteobacteria,1X6GZ@135614|Xanthomonadales	135614|Xanthomonadales	K	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons	nusB	-	-	ko:K03625	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	NusB
HKD2_k127_1513911_14	1049564.TevJSym_ad00720	2.132e-85	293.0	COG0611@1|root,COG0611@2|Bacteria,1MU9X@1224|Proteobacteria,1RNHU@1236|Gammaproteobacteria,1J5B5@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	F	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1	thiL	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009030,GO:0009058,GO:0009108,GO:0009110,GO:0009228,GO:0009229,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0017076,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0035639,GO:0036094,GO:0042357,GO:0042364,GO:0042723,GO:0042724,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046483,GO:0046872,GO:0051186,GO:0051188,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.7.4.16	ko:K00946	ko00730,ko01100,map00730,map01100	M00127	R00617	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	iSFV_1184.SFV_0382	AIRS,AIRS_C
HKD2_k127_1513911_11	391615.ABSJ01000027_gene186	9.863e-105	358.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,1S1T4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	KLT	Protein tyrosine kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase,cNMP_binding
HKD2_k127_1513911_9	396588.Tgr7_0830	7.779e-126	409.0	COG1469@1|root,COG1469@2|Bacteria,1MV1B@1224|Proteobacteria,1RNDY@1236|Gammaproteobacteria,1WW3H@135613|Chromatiales	135613|Chromatiales	S	Converts GTP to 7,8-dihydroneopterin triphosphate	folE2	-	3.5.4.16	ko:K09007	ko00790,ko01100,map00790,map01100	M00126	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	-	GCHY-1
HKD2_k127_1513911_4	1283300.ATXB01000001_gene847	7.51e-265	840.0	COG1154@1|root,COG1154@2|Bacteria,1MUSJ@1224|Proteobacteria,1RNQD@1236|Gammaproteobacteria,1XDS0@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)	dxs	-	2.2.1.7	ko:K01662	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	M00096	R05636	RC00032	ko00000,ko00001,ko00002,ko01000	-	-	-	DXP_synthase_N,Transket_pyr,Transketolase_C
HKD2_k127_1513911_12	1123401.JHYQ01000019_gene1505	3.527e-86	300.0	COG0142@1|root,COG0142@2|Bacteria,1MWNG@1224|Proteobacteria,1RMKY@1236|Gammaproteobacteria,4609B@72273|Thiotrichales	72273|Thiotrichales	H	Belongs to the FPP GGPP synthase family	ispA	-	2.5.1.1,2.5.1.10	ko:K00795	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364	R01658,R02003	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
HKD2_k127_1513911_22	1440052.EAKF1_ch1016	1.249e-17	85.0	COG1722@1|root,COG1722@2|Bacteria,1N72V@1224|Proteobacteria,1SC7N@1236|Gammaproteobacteria,3XQ1J@561|Escherichia	1236|Gammaproteobacteria	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseB	GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008855,GO:0009056,GO:0009057,GO:0009318,GO:0009987,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0019439,GO:0032991,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901361,GO:1901575,GO:1902494	3.1.11.6	ko:K03602	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_S
HKD2_k127_1513911_15	2340.JV46_02710	2.282e-77	261.0	COG1592@1|root,COG1592@2|Bacteria,1R9WG@1224|Proteobacteria,1S25G@1236|Gammaproteobacteria,1J92R@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Rubrerythrin	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
HKD2_k127_1513911_6	713586.KB900536_gene2898	2.464e-204	645.0	COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,1RQ9M@1236|Gammaproteobacteria,1WX1I@135613|Chromatiales	135613|Chromatiales	C	Cysteine-rich domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG
HKD2_k127_1513911_16	1266909.AUAG01000019_gene416	4.95e-74	255.0	COG0247@1|root,COG0247@2|Bacteria,1RF02@1224|Proteobacteria,1S302@1236|Gammaproteobacteria,1WX78@135613|Chromatiales	135613|Chromatiales	C	Protein of unknown function (DUF3501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3501
HKD2_k127_1513911_2	713586.KB900536_gene928	1.588e-307	953.0	COG0187@1|root,COG0187@2|Bacteria,1MVH1@1224|Proteobacteria,1RMCI@1236|Gammaproteobacteria,1WXIB@135613|Chromatiales	135613|Chromatiales	L	Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule	parE	-	-	ko:K02622	-	-	-	-	ko00000,ko01000,ko02048,ko03032,ko03036	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
HKD2_k127_1513911_1	713586.KB900536_gene926	0.0	1038.0	COG0188@1|root,COG0188@2|Bacteria,1MURI@1224|Proteobacteria,1RMTC@1236|Gammaproteobacteria,1WWE3@135613|Chromatiales	135613|Chromatiales	L	Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule	parC	-	-	ko:K02621	-	-	-	-	ko00000,ko01000,ko02048,ko03032,ko03036	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
HKD2_k127_1513911_13	1123261.AXDW01000005_gene2543	4.583e-86	311.0	COG2200@1|root,COG2204@1|root,COG2200@2|Bacteria,COG2204@2|Bacteria,1PJCA@1224|Proteobacteria,1RS4H@1236|Gammaproteobacteria,1X47Y@135614|Xanthomonadales	135614|Xanthomonadales	T	COG2202 FOG PAS PAC domain	-	-	-	ko:K21025	ko02025,map02025	-	-	-	ko00000,ko00001	-	-	-	EAL,GGDEF,PAS,PAS_8,PAS_9
HKD2_k127_1531127_1	349521.HCH_00285	6.246e-145	473.0	COG1158@1|root,COG1158@2|Bacteria,1MUCF@1224|Proteobacteria,1RP95@1236|Gammaproteobacteria,1XHZA@135619|Oceanospirillales	135619|Oceanospirillales	K	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template	rho	-	-	ko:K03628	ko03018,map03018	-	-	-	ko00000,ko00001,ko03019,ko03021	-	-	-	ATP-synt_ab,Rho_N,Rho_RNA_bind
HKD2_k127_1531127_2	765912.Thimo_2083	1.844e-46	169.0	COG3118@1|root,COG3118@2|Bacteria,1MZBB@1224|Proteobacteria,1S5WR@1236|Gammaproteobacteria,1WY87@135613|Chromatiales	135613|Chromatiales	O	Belongs to the thioredoxin family	-	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
HKD2_k127_1531127_0	713586.KB900536_gene2528	8.758e-161	522.0	COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,1RMWA@1236|Gammaproteobacteria,1WWMG@135613|Chromatiales	135613|Chromatiales	L	DEAD-box RNA helicase involved in RNA degradation. Has RNA-dependent ATPase activity and unwinds double-stranded RNA	rhlB	-	3.6.4.13	ko:K03732	ko03018,map03018	M00394	-	-	ko00000,ko00001,ko00002,ko01000,ko03019	-	-	-	DEAD,Helicase_C
HKD2_k127_1543777_3	290397.Adeh_2888	7.143e-40	155.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD2_k127_1543777_1	1123368.AUIS01000033_gene1370	5.661e-106	349.0	COG0426@1|root,COG0426@2|Bacteria,1MXIE@1224|Proteobacteria	1224|Proteobacteria	C	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HKD2_k127_1543777_2	318996.AXAZ01000120_gene2539	9.752e-100	336.0	COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,2TSG1@28211|Alphaproteobacteria,3JSYZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
HKD2_k127_1543777_0	1469245.JFBG01000080_gene290	1.171e-117	389.0	COG1163@1|root,COG1163@2|Bacteria,1RFPD@1224|Proteobacteria	1224|Proteobacteria	S	TGS domain	-	-	-	ko:K06944	-	-	-	-	ko00000	-	-	-	MMR_HSR1,TGS
HKD2_k127_1543777_4	1382306.JNIM01000001_gene2891	4.887e-26	110.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	GSDH,Phage-tail_3,TIG
HKD2_k127_1553749_4	1122603.ATVI01000005_gene3690	5.53e-37	154.0	COG2067@1|root,COG2067@2|Bacteria,1PXPC@1224|Proteobacteria,1RQKS@1236|Gammaproteobacteria,1X2X6@135614|Xanthomonadales	135614|Xanthomonadales	I	Protein of unknown function (DUF3570)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3570
HKD2_k127_1553749_5	1128912.GMES_2335	1.22e-22	100.0	2E3QA@1|root,32YN8@2|Bacteria,1N98P@1224|Proteobacteria,1SCNQ@1236|Gammaproteobacteria,4691P@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Domain of unknown function (DUF4266)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4266
HKD2_k127_1553749_3	395495.Lcho_2011	3.291e-37	145.0	COG0526@1|root,COG0526@2|Bacteria,1MZ36@1224|Proteobacteria,2VTF7@28216|Betaproteobacteria,1KPJ0@119065|unclassified Burkholderiales	28216|Betaproteobacteria	CO	Thioredoxin-like	-	-	-	-	-	-	-	-	-	-	-	-	Redoxin
HKD2_k127_1553749_1	290397.Adeh_2260	4.128e-142	464.0	COG1143@1|root,COG1143@2|Bacteria,1QYG4@1224|Proteobacteria,43E88@68525|delta/epsilon subdivisions,2X7N9@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1553749_0	234267.Acid_1889	1.312e-183	593.0	COG1132@1|root,COG1132@2|Bacteria,3Y6PT@57723|Acidobacteria	57723|Acidobacteria	V	ABC transporter transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
HKD2_k127_1553749_2	1280950.HJO_13121	1.517e-56	218.0	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,43XNB@69657|Hyphomonadaceae	28211|Alphaproteobacteria	T	Adenylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	TIR_2,TPR_16,TPR_8,Trans_reg_C
HKD2_k127_1553749_7	686340.Metal_3622	5.592e-18	89.0	2EAFX@1|root,334J9@2|Bacteria,1R3G6@1224|Proteobacteria,1TGY3@1236|Gammaproteobacteria,1XGX5@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_156400_2	523791.Kkor_2302	1.174e-106	374.0	COG5184@1|root,COG5184@2|Bacteria	2|Bacteria	DZ	guanyl-nucleotide exchange factor activity	-	-	-	-	-	-	-	-	-	-	-	-	Big_5,Cadherin-like,DUF3494,TIG
HKD2_k127_156400_4	1125863.JAFN01000001_gene1812	1.577e-18	101.0	COG1520@1|root,COG2931@1|root,COG3291@1|root,COG3386@1|root,COG1520@2|Bacteria,COG2931@2|Bacteria,COG3291@2|Bacteria,COG3386@2|Bacteria,1N8Z7@1224|Proteobacteria,43AIY@68525|delta/epsilon subdivisions	1224|Proteobacteria	C	heme-binding sites	-	-	-	-	-	-	-	-	-	-	-	-	PKD,Peptidase_C1
HKD2_k127_156400_0	105559.Nwat_2185	5.356e-146	469.0	COG1087@1|root,COG1087@2|Bacteria,1MUHI@1224|Proteobacteria,1RMTU@1236|Gammaproteobacteria,1WWNR@135613|Chromatiales	135613|Chromatiales	M	Belongs to the NAD(P)-dependent epimerase dehydratase family	-	-	5.1.3.2,5.1.3.5	ko:K01784,ko:K12448	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R01473,R02984	RC00289,RC00528	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
HKD2_k127_156400_1	243365.CV_1007	2.689e-126	413.0	COG2334@1|root,COG2334@2|Bacteria,1MU2Q@1224|Proteobacteria,2VI9A@28216|Betaproteobacteria,2KQPE@206351|Neisseriales	206351|Neisseriales	F	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response	srkA	-	-	-	-	-	-	-	-	-	-	-	APH
HKD2_k127_156400_3	1123368.AUIS01000005_gene447	1.984e-102	353.0	COG0642@1|root,COG2205@2|Bacteria,1N58A@1224|Proteobacteria,1RP34@1236|Gammaproteobacteria,2NBSM@225057|Acidithiobacillales	225057|Acidithiobacillales	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	2.7.13.3	ko:K07711	ko02020,ko02024,map02020,map02024	M00502	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA
HKD2_k127_156400_5	696747.NIES39_K02410	4.984e-14	74.0	COG1598@1|root,COG1598@2|Bacteria,1G985@1117|Cyanobacteria,1HD7M@1150|Oscillatoriales	1117|Cyanobacteria	S	HicB_like antitoxin of bacterial toxin-antitoxin system	-	-	-	-	-	-	-	-	-	-	-	-	HicB_lk_antitox
HKD2_k127_1588308_1	1095769.CAHF01000012_gene3414	1.823e-24	112.0	COG1686@1|root,COG1686@2|Bacteria,1MWZA@1224|Proteobacteria,2VH1S@28216|Betaproteobacteria,47397@75682|Oxalobacteraceae	28216|Betaproteobacteria	M	Belongs to the peptidase S11 family	pbpG	-	-	ko:K07262	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_S11
HKD2_k127_1588308_0	1379270.AUXF01000002_gene1717	1.165e-161	546.0	COG5001@1|root,COG5001@2|Bacteria,1ZT12@142182|Gemmatimonadetes	142182|Gemmatimonadetes	T	Putative diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS
HKD2_k127_1588308_2	1232410.KI421424_gene1819	7.866e-20	91.0	2E9MH@1|root,333U5@2|Bacteria,1NDRZ@1224|Proteobacteria,42VYW@68525|delta/epsilon subdivisions,2WR91@28221|Deltaproteobacteria,43VTK@69541|Desulfuromonadales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1592438_0	1380394.JADL01000010_gene4323	1.693e-223	700.0	COG0633@1|root,COG3894@1|root,COG0633@2|Bacteria,COG3894@2|Bacteria,1MV6C@1224|Proteobacteria,2TUJB@28211|Alphaproteobacteria,2JQGJ@204441|Rhodospirillales	204441|Rhodospirillales	C	Domain of unknown function (DUF4445)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4445,Fer2
HKD2_k127_1592438_2	748247.AZKH_p0164	1.778e-151	493.0	COG1410@1|root,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,2VHYQ@28216|Betaproteobacteria	1224|Proteobacteria	H	Vitamin B12 dependent methionine synthase activation	metH	-	2.1.1.13,2.1.1.258	ko:K00548,ko:K15023	ko00270,ko00450,ko00670,ko00720,ko01100,ko01110,ko01120,ko01200,ko01230,map00270,map00450,map00670,map00720,map01100,map01110,map01120,map01200,map01230	M00017,M00377	R00946,R02289,R09365,R10243	RC00004,RC00035,RC00113,RC01144,RC01241,RC02871,RC02977	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
HKD2_k127_1592438_1	748247.AZKH_p0165	1.084e-178	576.0	COG0685@1|root,COG0685@2|Bacteria,1MXTZ@1224|Proteobacteria	1224|Proteobacteria	E	Methylenetetrahydrofolate reductase	metF	-	1.5.1.20,2.1.1.10	ko:K00297,ko:K00547	ko00270,ko00670,ko00720,ko01100,ko01110,ko01120,ko01200,ko01523,map00270,map00670,map00720,map01100,map01110,map01120,map01200,map01523	M00377	R00650,R01224,R07168	RC00003,RC00035,RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	MTHFR
HKD2_k127_1592438_5	1380391.JIAS01000001_gene2818	2.558e-66	228.0	COG0685@1|root,COG0685@2|Bacteria,1RHDY@1224|Proteobacteria,2U4I0@28211|Alphaproteobacteria,2JWQ3@204441|Rhodospirillales	204441|Rhodospirillales	E	Methylene-tetrahydrofolate reductase C terminal	-	-	-	-	-	-	-	-	-	-	-	-	MTHFR_C
HKD2_k127_1592438_6	748247.AZKH_p0167	7.037e-33	139.0	2CDZD@1|root,32RYT@2|Bacteria,1N0AT@1224|Proteobacteria	1224|Proteobacteria	S	Virulence factor	-	-	-	-	-	-	-	-	-	-	-	-	Virulence_fact
HKD2_k127_1592438_4	748247.AZKH_p0168	1.609e-66	243.0	28I8Y@1|root,2Z8BR@2|Bacteria,1MXN1@1224|Proteobacteria	1224|Proteobacteria	S	Protein of unknown function (DUF1638)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1638
HKD2_k127_1592438_3	748247.AZKH_p0169	7.461e-109	354.0	COG5012@1|root,COG5012@2|Bacteria	2|Bacteria	T	cobalamin binding	mtbC	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2
HKD2_k127_1633836_0	243159.AFE_1816	0.0	1134.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,1RP3T@1236|Gammaproteobacteria,2NC9Q@225057|Acidithiobacillales	225057|Acidithiobacillales	H	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
HKD2_k127_164756_5	243365.CV_1374	6.599e-96	344.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,2KQJ6@206351|Neisseriales	206351|Neisseriales	T	signal transduction protein containing a membrane domain, an EAL and a GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS,EAL,GGDEF,PAS_9
HKD2_k127_164756_15	666685.R2APBS1_3664	1.478e-08	63.0	COG1983@1|root,COG1983@2|Bacteria	2|Bacteria	KT	positive regulation of macromolecule biosynthetic process	-	-	-	ko:K03973	-	-	-	-	ko00000,ko02048,ko03000	-	-	-	PspC
HKD2_k127_164756_10	452637.Oter_4530	8.352e-38	145.0	COG1695@1|root,COG1695@2|Bacteria	2|Bacteria	K	negative regulation of transcription, DNA-templated	-	-	-	ko:K10947	-	-	-	-	ko00000,ko03000	-	-	-	PadR
HKD2_k127_164756_9	1123073.KB899244_gene350	1.05e-76	269.0	COG0491@1|root,COG0491@2|Bacteria,1QBJF@1224|Proteobacteria,1T752@1236|Gammaproteobacteria,1X8SQ@135614|Xanthomonadales	135614|Xanthomonadales	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HKD2_k127_164756_6	1828.JOKB01000065_gene4305	3.698e-88	304.0	COG1063@1|root,COG1063@2|Bacteria,2GKC7@201174|Actinobacteria,4FVNK@85025|Nocardiaceae	201174|Actinobacteria	E	Alcohol dehydrogenase GroES-like domain	-	-	1.1.1.303,1.1.1.4	ko:K00004	ko00650,map00650	-	R02855,R02946,R10504	RC00205,RC00525	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
HKD2_k127_164756_7	1211112.ALJC01000006_gene143	8.218e-79	273.0	COG1028@1|root,COG1028@2|Bacteria,1R86W@1224|Proteobacteria,1SK3B@1236|Gammaproteobacteria	1236|Gammaproteobacteria	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HKD2_k127_164756_1	1286093.C266_15487	8.944e-198	633.0	COG2303@1|root,COG2303@2|Bacteria,1MU3F@1224|Proteobacteria,2VIBA@28216|Betaproteobacteria,1KFJJ@119060|Burkholderiaceae	28216|Betaproteobacteria	E	PFAM glucose-methanol-choline oxidoreductase	-	-	1.1.3.6	ko:K03333	ko00984,ko01120,map00984,map01120	-	R01459	RC00146	ko00000,ko00001,ko01000	-	-	-	GMC_oxred_C,GMC_oxred_N,NAD_binding_8
HKD2_k127_164756_11	402626.Rpic_2535	3.784e-36	156.0	2BXMA@1|root,2ZBQ1@2|Bacteria,1MXZ1@1224|Proteobacteria,2VT1H@28216|Betaproteobacteria,1K4UA@119060|Burkholderiaceae	28216|Betaproteobacteria	S	(twin-arginine translocation) pathway signal	-	-	-	-	-	-	-	-	-	-	-	-	Gluconate_2-dh3
HKD2_k127_164756_3	1492922.GY26_12970	7.019e-150	492.0	COG2271@1|root,COG2271@2|Bacteria,1QWH9@1224|Proteobacteria,1T3YV@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
HKD2_k127_164756_8	627192.SLG_20040	1.486e-78	273.0	COG1028@1|root,COG1028@2|Bacteria,1MYGI@1224|Proteobacteria,2UAWY@28211|Alphaproteobacteria,2KABI@204457|Sphingomonadales	204457|Sphingomonadales	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HKD2_k127_164756_14	627192.SLG_20050	2.497e-14	85.0	2FHPP@1|root,349H9@2|Bacteria,1NC8W@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_164756_0	627192.SLG_20060	2.655e-248	775.0	COG1233@1|root,COG1233@2|Bacteria,1MV2R@1224|Proteobacteria,2TSR0@28211|Alphaproteobacteria,2K3Q1@204457|Sphingomonadales	204457|Sphingomonadales	Q	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase,NAD_binding_8
HKD2_k127_164756_12	627192.SLG_20090	1.554e-35	139.0	COG3631@1|root,COG3631@2|Bacteria,1N5XE@1224|Proteobacteria,2V5KX@28211|Alphaproteobacteria,2K76M@204457|Sphingomonadales	204457|Sphingomonadales	S	SnoaL-like domain	-	-	-	ko:K06893	-	-	-	-	ko00000	-	-	-	SnoaL_2
HKD2_k127_164756_2	627192.SLG_20150	9.955e-160	512.0	COG2124@1|root,COG2124@2|Bacteria,1MY2E@1224|Proteobacteria,2TTFN@28211|Alphaproteobacteria,2K2GY@204457|Sphingomonadales	204457|Sphingomonadales	C	Cytochrome P450	-	-	-	-	-	-	-	-	-	-	-	-	p450
HKD2_k127_164756_4	627192.SLG_20160	1.492e-97	331.0	COG0491@1|root,COG0491@2|Bacteria,1N22F@1224|Proteobacteria,2U2V5@28211|Alphaproteobacteria,2K3EH@204457|Sphingomonadales	204457|Sphingomonadales	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HKD2_k127_164756_13	1492922.GY26_00650	1.316e-28	117.0	COG2303@1|root,COG2303@2|Bacteria,1MV19@1224|Proteobacteria,1RMD2@1236|Gammaproteobacteria,1J8SR@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate	betA	GO:0001505,GO:0003674,GO:0003824,GO:0005575,GO:0006091,GO:0006113,GO:0006575,GO:0006577,GO:0006578,GO:0006807,GO:0006950,GO:0006970,GO:0008150,GO:0008152,GO:0008812,GO:0009058,GO:0009628,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016614,GO:0019285,GO:0019695,GO:0031455,GO:0031456,GO:0034641,GO:0042133,GO:0042398,GO:0044237,GO:0044249,GO:0044271,GO:0050896,GO:0055114,GO:0065007,GO:0065008,GO:0071704,GO:0097164,GO:1901564,GO:1901566,GO:1901576	1.1.99.1	ko:K00108	ko00260,ko01100,map00260,map01100	M00555	R01025	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	iAPECO1_1312.APECO1_1679,iECDH10B_1368.ECDH10B_0298,iECDH1ME8569_1439.ECDH1ME8569_0299,iECH74115_1262.ECH74115_0373,iECOK1_1307.ECOK1_0305,iECS88_1305.ECS88_0319,iECSP_1301.ECSP_0366,iECs_1301.ECs0357,iEcDH1_1363.EcDH1_3295,iEcolC_1368.EcolC_3312,iG2583_1286.G2583_0415,iJN746.PP_5064,iJO1366.b0311,iUMN146_1321.UM146_15745,iY75_1357.Y75_RS01610,iZ_1308.Z0398	GMC_oxred_C,GMC_oxred_N
HKD2_k127_1667724_1	396588.Tgr7_3035	7.144e-144	475.0	COG0568@1|root,COG0568@2|Bacteria,1MVNJ@1224|Proteobacteria,1RMQI@1236|Gammaproteobacteria,1WWD1@135613|Chromatiales	135613|Chromatiales	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	rpoD	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_ner,Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
HKD2_k127_1667724_0	765911.Thivi_4083	8.905e-175	569.0	COG0358@1|root,COG0358@2|Bacteria,1MUHC@1224|Proteobacteria,1RMGA@1236|Gammaproteobacteria,1WX02@135613|Chromatiales	135613|Chromatiales	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB_bind,DnaG_DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2
HKD2_k127_1667724_2	1163409.UUA_10596	3.542e-09	58.0	COG1610@1|root,COG1610@2|Bacteria,1RGZS@1224|Proteobacteria,1S61A@1236|Gammaproteobacteria,1X6H1@135614|Xanthomonadales	135614|Xanthomonadales	S	Glutamyl-tRNA amidotransferase	-	-	-	ko:K09117	-	-	-	-	ko00000	-	-	-	YqeY
HKD2_k127_1693362_6	1121015.N789_00840	2.816e-109	359.0	COG0059@1|root,COG0059@2|Bacteria,1MV7M@1224|Proteobacteria,1RNA8@1236|Gammaproteobacteria,1X35R@135614|Xanthomonadales	135614|Xanthomonadales	EH	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate	ilvC	-	1.1.1.86	ko:K00053	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R03051,R04439,R04440,R05068,R05069,R05071	RC00726,RC00836,RC00837,RC01726	ko00000,ko00001,ko00002,ko01000	-	-	-	IlvC,IlvN
HKD2_k127_1693362_4	414684.RC1_2330	4.357e-139	457.0	COG0260@1|root,COG0260@2|Bacteria,1MUIN@1224|Proteobacteria,2TSI6@28211|Alphaproteobacteria,2JPVI@204441|Rhodospirillales	204441|Rhodospirillales	E	Belongs to the peptidase M17 family	pepB	-	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17
HKD2_k127_1693362_1	794903.OPIT5_03680	7.162e-250	783.0	COG0129@1|root,COG0129@2|Bacteria,46SBY@74201|Verrucomicrobia,3K7M4@414999|Opitutae	414999|Opitutae	EG	Dehydratase family	-	-	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
HKD2_k127_1693362_12	3988.XP_002535794.1	2.956e-41	161.0	2EVHH@1|root,2SXH0@2759|Eukaryota	2759|Eukaryota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1693362_7	987059.RBXJA2T_14851	2.419e-78	268.0	COG0811@1|root,COG0811@2|Bacteria,1NMPB@1224|Proteobacteria,2VJ4U@28216|Betaproteobacteria,1KJUF@119065|unclassified Burkholderiales	28216|Betaproteobacteria	U	PFAM MotA TolQ ExbB proton channel	exbB1	-	-	ko:K03561	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	MotA_ExbB
HKD2_k127_1693362_10	414684.RC1_0682	2.908e-49	179.0	COG0848@1|root,COG0848@2|Bacteria,1RH4U@1224|Proteobacteria,2UBQK@28211|Alphaproteobacteria,2JWSK@204441|Rhodospirillales	204441|Rhodospirillales	U	TonB dependent biopolymer transporter integral cytoplasmic membrane subunit, working with ExbB	-	-	-	ko:K03559	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	ExbD
HKD2_k127_1693362_13	983917.RGE_34400	7.662e-41	154.0	COG0848@1|root,COG0848@2|Bacteria,1RHDF@1224|Proteobacteria,2VT16@28216|Betaproteobacteria,1KM2K@119065|unclassified Burkholderiales	28216|Betaproteobacteria	U	PFAM Biopolymer transport protein ExbD TolR	exbD2	-	-	ko:K03559	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	ExbD
HKD2_k127_1693362_11	1209072.ALBT01000012_gene3452	1.272e-41	169.0	COG4105@1|root,COG4105@2|Bacteria,1NA84@1224|Proteobacteria,1SHM0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1693362_14	1120919.AUBI01000010_gene114	5.25e-39	161.0	COG0457@1|root,COG0457@2|Bacteria,1Q7UR@1224|Proteobacteria,2U8BX@28211|Alphaproteobacteria,2JWW5@204441|Rhodospirillales	204441|Rhodospirillales	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16
HKD2_k127_1693362_9	1121124.JNIX01000015_gene1935	1.089e-50	192.0	COG0346@1|root,COG0346@2|Bacteria,1RDMC@1224|Proteobacteria,2U8A2@28211|Alphaproteobacteria,2KJ97@204458|Caulobacterales	204458|Caulobacterales	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1693362_8	279238.Saro_0173	6.369e-73	256.0	COG1335@1|root,COG1335@2|Bacteria,1NZJ1@1224|Proteobacteria,2VG5P@28211|Alphaproteobacteria,2K4F2@204457|Sphingomonadales	204457|Sphingomonadales	Q	Isochorismatase family	-	-	3.5.1.107	ko:K13995	ko00760,ko01120,map00760,map01120	M00622	R03540	RC00950	ko00000,ko00001,ko00002,ko01000	-	-	-	Isochorismatase
HKD2_k127_1693362_3	1342299.Z947_1607	1.22e-175	563.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2TR7Q@28211|Alphaproteobacteria,3ZV8J@60136|Sulfitobacter	28211|Alphaproteobacteria	C	CoA-transferase family III	-	-	2.8.3.16	ko:K07749	-	-	-	-	ko00000,ko01000	-	-	-	CoA_transf_3
HKD2_k127_1693362_5	298653.Franean1_3719	1.364e-120	397.0	COG0119@1|root,COG0119@2|Bacteria,2GKTP@201174|Actinobacteria,4ES54@85013|Frankiales	201174|Actinobacteria	E	PFAM Pyruvate carboxyltransferase	-	-	4.1.3.4,4.1.3.46	ko:K01640,ko:K18314	ko00072,ko00280,ko00281,ko00650,ko01100,ko04146,map00072,map00280,map00281,map00650,map01100,map04146	M00036,M00088	R01360,R08090,R10674	RC00502,RC00503,RC01118,RC01205,RC01946	ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like
HKD2_k127_1693362_0	247639.MGP2080_08139	5.118e-281	880.0	COG0145@1|root,COG0145@2|Bacteria,1MU2Y@1224|Proteobacteria,1RN6C@1236|Gammaproteobacteria,1JA1T@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	EQ	Hydantoinase/oxoprolinase N-terminal region	hyuA	-	3.5.2.14	ko:K01473	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydant_A_N,Hydantoinase_A
HKD2_k127_1693362_2	247639.MGP2080_08144	2.665e-183	578.0	COG0146@1|root,COG0146@2|Bacteria,1QU46@1224|Proteobacteria,1T2DW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	EQ	COG0146 N-methylhydantoinase B acetone carboxylase, alpha subunit	hyuB	-	3.5.2.14	ko:K01474	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydantoinase_B
HKD2_k127_1697008_2	946362.XP_004994854.1	1.216e-30	131.0	KOG1695@1|root,KOG1695@2759|Eukaryota,3A52M@33154|Opisthokonta	33154|Opisthokonta	O	Glutathione S-transferase, C-terminal domain	-	-	2.5.1.18,5.3.99.2	ko:K04097	ko00480,ko00590,ko00980,ko00982,ko01100,ko05204,map00480,map00590,map00980,map00982,map01100,map05204	-	R02266,R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409	RC00004,RC00069,RC00672,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000	-	-	-	GST_C_3,GST_N
HKD2_k127_1697008_4	471854.Dfer_4315	6.894e-06	55.0	2DBYP@1|root,2ZBWI@2|Bacteria,4PPYC@976|Bacteroidetes,47PBE@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1697008_3	700598.Niako_3519	2.733e-06	55.0	2CAXD@1|root,2ZFE9@2|Bacteria,4P87A@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1697008_1	1122603.ATVI01000006_gene2	2.191e-45	167.0	COG3324@1|root,COG3324@2|Bacteria,1QXUH@1224|Proteobacteria	1224|Proteobacteria	S	Glyoxalase-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HKD2_k127_1697008_0	1121948.AUAC01000005_gene2012	5.321e-54	201.0	COG5616@1|root,COG5616@2|Bacteria,1NSKC@1224|Proteobacteria,2TWZ1@28211|Alphaproteobacteria,44159@69657|Hyphomonadaceae	28211|Alphaproteobacteria	K	cAMP biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,Trans_reg_C
HKD2_k127_172241_8	472759.Nhal_1698	2.536e-05	53.0	29FX1@1|root,34453@2|Bacteria,1P3CX@1224|Proteobacteria,1SVJS@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_172241_2	1121396.KB893080_gene898	9.665e-83	300.0	COG0642@1|root,COG2205@2|Bacteria,1QUJ7@1224|Proteobacteria,43BJF@68525|delta/epsilon subdivisions,2WU4G@28221|Deltaproteobacteria,2MMQM@213118|Desulfobacterales	28221|Deltaproteobacteria	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
HKD2_k127_172241_3	381666.H16_A1818	6.48e-81	277.0	COG0745@1|root,COG0745@2|Bacteria,1MU3A@1224|Proteobacteria,2VJTG@28216|Betaproteobacteria,1K25X@119060|Burkholderiaceae	28216|Betaproteobacteria	K	Two component transcriptional regulator, winged helix family	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
HKD2_k127_172241_5	529818.AMSG_11713T0	5.886e-29	134.0	COG0666@1|root,COG4886@1|root,KOG0531@2759|Eukaryota,KOG4177@2759|Eukaryota	2759|Eukaryota	I	spectrin binding	-	GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0031974,GO:0031981,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044464,GO:0070013	-	ko:K15502,ko:K15503,ko:K16717	-	-	-	-	ko00000,ko01009,ko03036,ko03400	-	-	-	Ank,Ank_2,Ank_3,Ank_4,Motile_Sperm
HKD2_k127_172241_0	1049564.TevJSym_ar00380	4.162e-165	530.0	COG0492@1|root,COG1145@1|root,COG0492@2|Bacteria,COG1145@2|Bacteria,1QYEW@1224|Proteobacteria,1T3PI@1236|Gammaproteobacteria,1JAK0@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_5,Pyr_redox_3
HKD2_k127_172241_7	765914.ThisiDRAFT_1529	6.36e-09	67.0	COG4235@1|root,COG4235@2|Bacteria,1MY4J@1224|Proteobacteria,1RZEA@1236|Gammaproteobacteria,1WWTV@135613|Chromatiales	135613|Chromatiales	O	TIGRFAM Cytochrome c-type biogenesis protein CcmI	-	-	-	ko:K02200	-	-	-	-	ko00000	-	-	-	TPR_16,TPR_2
HKD2_k127_172241_4	1049564.TevJSym_ar00370	6.856e-52	198.0	COG1142@1|root,COG1142@2|Bacteria,1RIXA@1224|Proteobacteria,1SBMD@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	4fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_172241_1	243233.MCA2189	1.801e-162	526.0	COG0484@1|root,COG0484@2|Bacteria,1MXM9@1224|Proteobacteria,1T3FX@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	heat shock protein binding	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C7
HKD2_k127_172241_6	580332.Slit_0868	1.57e-25	111.0	COG0484@1|root,COG0484@2|Bacteria,1Q629@1224|Proteobacteria,2VJ8G@28216|Betaproteobacteria	1224|Proteobacteria	C	Cytochrome c7 and related cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_c3_2,Cytochrome_C554,Cytochrome_C7,Paired_CXXCH_1
HKD2_k127_17261_4	1231391.AMZF01000022_gene1263	5.029e-38	157.0	COG3274@1|root,COG3274@2|Bacteria,1PX98@1224|Proteobacteria,2VS6C@28216|Betaproteobacteria,3T1HQ@506|Alcaligenaceae	28216|Betaproteobacteria	S	Acyltransferase family	yiaH	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
HKD2_k127_17261_3	1410665.JNKR01000011_gene878	5.039e-41	162.0	COG0726@1|root,COG0726@2|Bacteria,1V6AW@1239|Firmicutes,4H326@909932|Negativicutes	909932|Negativicutes	G	Polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
HKD2_k127_17261_1	1001240.GY21_18845	9.548e-159	526.0	COG1215@1|root,COG1215@2|Bacteria,2GN8M@201174|Actinobacteria,4FKYF@85023|Microbacteriaceae	201174|Actinobacteria	M	Glycosyl transferase family group 2	-	-	-	-	-	-	-	-	-	-	-	-	EAL,Glyco_trans_2_3
HKD2_k127_17261_0	666685.R2APBS1_1154	3.106e-176	571.0	COG3055@1|root,COG3055@2|Bacteria,1NHAC@1224|Proteobacteria,1RYBY@1236|Gammaproteobacteria,1XAGU@135614|Xanthomonadales	135614|Xanthomonadales	S	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_17261_2	1057002.KB905370_gene2611	9.699e-106	364.0	COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,4B9BA@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	Adenylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,TPR_8
HKD2_k127_17261_5	1280944.HY17_10900	9.248e-34	149.0	COG1262@1|root,COG4916@1|root,COG1262@2|Bacteria,COG4916@2|Bacteria,1NQ5K@1224|Proteobacteria,2U2VJ@28211|Alphaproteobacteria,43ZFH@69657|Hyphomonadaceae	28211|Alphaproteobacteria	M	Sulfatase-modifying factor enzyme 1	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase,Guanylate_cyc
HKD2_k127_17261_7	1437882.AZRU01000060_gene4083	0.0003359	49.0	2EKQ7@1|root,33EDZ@2|Bacteria,1NHK0@1224|Proteobacteria,1SAXC@1236|Gammaproteobacteria,1YH77@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	S	Protein of unknown function (DUF2845)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2845
HKD2_k127_17261_6	1500257.JQNM01000003_gene5483	1.351e-15	82.0	COG4319@1|root,COG4319@2|Bacteria,1NG70@1224|Proteobacteria,2UIGE@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_2
HKD2_k127_174784_3	768671.ThimaDRAFT_1028	5.103e-52	204.0	COG0206@1|root,COG0206@2|Bacteria,1MV2X@1224|Proteobacteria,1RPZS@1236|Gammaproteobacteria,1WXJ6@135613|Chromatiales	135613|Chromatiales	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
HKD2_k127_174784_0	713586.KB900536_gene1368	1.895e-211	664.0	COG0849@1|root,COG0849@2|Bacteria,1MUSR@1224|Proteobacteria,1RMXY@1236|Gammaproteobacteria,1WVUV@135613|Chromatiales	135613|Chromatiales	D	Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring	ftsA	-	-	ko:K03590	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036,ko04812	-	-	-	FtsA,SHS2_FTSA
HKD2_k127_174784_4	1429851.X548_01630	6.15e-38	152.0	COG1589@1|root,COG1589@2|Bacteria,1N0T7@1224|Proteobacteria,1S9FJ@1236|Gammaproteobacteria,1X5H6@135614|Xanthomonadales	135614|Xanthomonadales	D	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly	ftsQ	-	-	ko:K03589	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036	-	-	-	FtsQ,POTRA_1
HKD2_k127_174784_1	1121015.N789_11345	1.898e-140	461.0	COG1181@1|root,COG1181@2|Bacteria,1MUTB@1224|Proteobacteria,1RMTM@1236|Gammaproteobacteria,1X46K@135614|Xanthomonadales	135614|Xanthomonadales	F	Belongs to the D-alanine--D-alanine ligase family	ddl	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C,Dala_Dala_lig_N
HKD2_k127_174784_2	1123400.KB904780_gene1823	2.333e-122	399.0	COG0773@1|root,COG0773@2|Bacteria,1MV68@1224|Proteobacteria,1RN88@1236|Gammaproteobacteria,45ZR5@72273|Thiotrichales	72273|Thiotrichales	M	Belongs to the MurCDEF family	murC	-	6.3.2.8	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R03193	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
HKD2_k127_1750151_11	1192034.CAP_5764	3.947e-157	508.0	COG4690@1|root,COG4690@2|Bacteria,1RBRZ@1224|Proteobacteria	1224|Proteobacteria	E	dipeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C69
HKD2_k127_1750151_14	438753.AZC_4594	7.565e-84	287.0	COG0518@1|root,COG0518@2|Bacteria,1Q2PQ@1224|Proteobacteria,2U196@28211|Alphaproteobacteria,3F0JM@335928|Xanthobacteraceae	28211|Alphaproteobacteria	F	Peptidase C26	-	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase
HKD2_k127_1750151_9	570952.ATVH01000013_gene2789	2.203e-174	556.0	COG1454@1|root,COG1454@2|Bacteria,1MVPH@1224|Proteobacteria,2TSX8@28211|Alphaproteobacteria,2JQNE@204441|Rhodospirillales	204441|Rhodospirillales	C	Iron-containing alcohol dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Fe-ADH
HKD2_k127_1750151_5	1380394.JADL01000011_gene3947	5.262e-214	676.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2TRJV@28211|Alphaproteobacteria,2JP8V@204441|Rhodospirillales	204441|Rhodospirillales	C	Aldehyde dehydrogenase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldedh
HKD2_k127_1750151_4	1101190.ARWB01000001_gene2870	2.438e-214	702.0	COG0174@1|root,COG0174@2|Bacteria,1MUGQ@1224|Proteobacteria,2TU6U@28211|Alphaproteobacteria,36ZZV@31993|Methylocystaceae	28211|Alphaproteobacteria	E	Glutamine synthetase, catalytic domain	-	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C
HKD2_k127_1750151_7	1245471.PCA10_32540	1.333e-195	624.0	COG0531@1|root,COG0531@2|Bacteria,1MX13@1224|Proteobacteria	1224|Proteobacteria	E	amino acid	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
HKD2_k127_1750151_12	670487.Ocepr_1059	2.838e-101	346.0	COG4992@1|root,COG4992@2|Bacteria,1WIII@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	argD	-	2.6.1.13,2.6.1.82	ko:K00819,ko:K09251	ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130	-	R00667,R01155	RC00006,RC00062	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_3
HKD2_k127_1750151_26	1121468.AUBR01000001_gene460	3.903e-26	115.0	COG3255@1|root,COG3255@2|Bacteria,1V88A@1239|Firmicutes,24KTK@186801|Clostridia	186801|Clostridia	I	SCP-2 sterol transfer family	-	-	-	-	-	-	-	-	-	-	-	-	SCP2
HKD2_k127_1750151_13	370438.PTH_0785	1.542e-95	331.0	COG1113@1|root,COG1113@2|Bacteria,1UJS3@1239|Firmicutes,24F0Q@186801|Clostridia,2616D@186807|Peptococcaceae	186801|Clostridia	E	Amino acid permease	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
HKD2_k127_1750151_0	279238.Saro_0250	3.36e-272	863.0	COG1629@1|root,COG4771@2|Bacteria,1MWKN@1224|Proteobacteria,2UPQH@28211|Alphaproteobacteria,2KEDS@204457|Sphingomonadales	204457|Sphingomonadales	P	TonB dependent receptor	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
HKD2_k127_1750151_15	861299.J421_2010	2.358e-76	270.0	COG4221@1|root,COG4221@2|Bacteria	2|Bacteria	IQ	oxidoreductase activity	vdlC	-	-	-	-	-	-	-	-	-	-	-	adh_short
HKD2_k127_1750151_3	272560.BPSS2026	1.089e-220	695.0	COG1070@1|root,COG1070@2|Bacteria,1MW4A@1224|Proteobacteria,2VPTU@28216|Betaproteobacteria,1KDJU@119060|Burkholderiaceae	28216|Betaproteobacteria	G	FGGY family of carbohydrate kinase, N-terminal domain protein	xylB2	-	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
HKD2_k127_1750151_18	648885.KB316282_gene950	2.453e-61	226.0	COG0483@1|root,COG0483@2|Bacteria,1PPJ0@1224|Proteobacteria,2TQTX@28211|Alphaproteobacteria,1JQQR@119045|Methylobacteriaceae	28211|Alphaproteobacteria	G	PFAM Inositol monophosphatase	hisN	-	3.1.3.15,3.1.3.25,3.1.3.93	ko:K01092,ko:K18649	ko00053,ko00340,ko00521,ko00562,ko01100,ko01110,ko01230,ko04070,map00053,map00340,map00521,map00562,map01100,map01110,map01230,map04070	M00026,M00114,M00131	R01185,R01186,R01187,R03013,R07674	RC00017,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
HKD2_k127_1750151_2	272560.BPSS2021	1.012e-221	695.0	COG0076@1|root,COG0076@2|Bacteria,1MX25@1224|Proteobacteria,2W26D@28216|Betaproteobacteria,1KADQ@119060|Burkholderiaceae	28216|Betaproteobacteria	E	to Mus musculus sphingosine-1-phosphate lyase Sgpl1 SWALL O54955 (EMBL AF036894) (568 aa) fasta scores E()	-	-	4.1.2.27	ko:K01634	ko00600,ko01100,ko04071,map00600,map01100,map04071	M00100	R02464,R06516	RC00264,RC00721,RC01266	ko00000,ko00001,ko00002,ko01000	-	-	-	Pyridoxal_deC
HKD2_k127_1750151_23	566466.NOR53_2924	2.215e-32	141.0	COG0477@1|root,COG2814@2|Bacteria,1PESI@1224|Proteobacteria,1RU5E@1236|Gammaproteobacteria,1J8GW@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	EGP	GEPR COG0477 Permeases of the major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD2_k127_1750151_20	1286093.C266_03473	3e-51	199.0	COG4585@1|root,COG5278@1|root,COG4585@2|Bacteria,COG5278@2|Bacteria,1MWPN@1224|Proteobacteria,2VJR2@28216|Betaproteobacteria,1K4ZR@119060|Burkholderiaceae	28216|Betaproteobacteria	T	Histidine kinase	vsrA	-	2.7.13.1	ko:K05962	-	-	-	-	ko00000,ko01000	-	-	-	CHASE3,HATPase_c,HisKA_3
HKD2_k127_1750151_28	1266925.JHVX01000010_gene1421	2.706e-17	86.0	COG2823@1|root,COG2823@2|Bacteria,1NFG5@1224|Proteobacteria,2W46W@28216|Betaproteobacteria,373KJ@32003|Nitrosomonadales	28216|Betaproteobacteria	S	BON domain	-	-	-	-	-	-	-	-	-	-	-	-	BON
HKD2_k127_1750151_8	748280.NH8B_2742	1.262e-181	584.0	COG1502@1|root,COG1502@2|Bacteria,1MUDJ@1224|Proteobacteria,2VHSI@28216|Betaproteobacteria,2KQD0@206351|Neisseriales	206351|Neisseriales	I	Phospholipase D. Active site motifs.	-	-	-	ko:K06132	ko00564,ko01100,map00564,map01100	-	R11062	RC00017	ko00000,ko00001,ko01000	-	-	-	PLDc_2
HKD2_k127_1750151_27	1265502.KB905939_gene2370	2.058e-21	98.0	COG0784@1|root,COG0784@2|Bacteria,1QVYQ@1224|Proteobacteria,2WGV7@28216|Betaproteobacteria	28216|Betaproteobacteria	T	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
HKD2_k127_1750151_16	381666.H16_A0153	2.237e-74	255.0	COG2197@1|root,COG2197@2|Bacteria,1MWGM@1224|Proteobacteria,2VHQ0@28216|Betaproteobacteria,1K11T@119060|Burkholderiaceae	28216|Betaproteobacteria	K	response regulator	vsrD	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HKD2_k127_1750151_22	312153.Pnuc_2048	2.856e-41	159.0	2E560@1|root,32ZYT@2|Bacteria,1N9G1@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1750151_21	1117943.SFHH103_02567	3.333e-51	190.0	COG1877@1|root,COG1877@2|Bacteria,1RGY2@1224|Proteobacteria,2U9NF@28211|Alphaproteobacteria,4BCQC@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	Removes the phosphate from trehalose 6-phosphate to produce free trehalose	otsB	-	3.1.3.12	ko:K01087	ko00500,ko01100,map00500,map01100	-	R02778	RC00017	ko00000,ko00001,ko01000	-	-	-	Trehalose_PPase
HKD2_k127_1750151_1	1316936.K678_13695	5.346e-222	705.0	COG3387@1|root,COG3387@2|Bacteria,1MV08@1224|Proteobacteria,2TRMQ@28211|Alphaproteobacteria,2JQKZ@204441|Rhodospirillales	204441|Rhodospirillales	G	Glycosyl hydrolases family 15	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_15
HKD2_k127_1750151_6	1150626.PHAMO_210186	2.717e-199	638.0	COG0380@1|root,COG0380@2|Bacteria,1MUIY@1224|Proteobacteria,2TQMP@28211|Alphaproteobacteria,2JPVA@204441|Rhodospirillales	204441|Rhodospirillales	G	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor	otsA	-	2.4.1.15,2.4.1.347	ko:K00697	ko00500,ko01100,map00500,map01100	-	R02737	RC00005,RC00049,RC02748	ko00000,ko00001,ko01000,ko01003	-	GT20	-	Glyco_transf_20
HKD2_k127_1750151_17	1396418.BATQ01000136_gene3705	7.389e-72	259.0	COG1502@1|root,COG1502@2|Bacteria,46U9X@74201|Verrucomicrobia,2ITQD@203494|Verrucomicrobiae	203494|Verrucomicrobiae	I	Phospholipase D. Active site motifs.	-	-	-	-	-	-	-	-	-	-	-	-	PLDc_2
HKD2_k127_1750151_24	392500.Swoo_3426	4.778e-28	117.0	COG3809@1|root,COG3809@2|Bacteria,1QSA6@1224|Proteobacteria,1RXZ4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Transcription factor zinc-finger	-	-	-	ko:K09981	-	-	-	-	ko00000	-	-	-	zf-TFIIB
HKD2_k127_1750151_10	1117647.M5M_01555	1.204e-169	550.0	COG2234@1|root,COG2234@2|Bacteria,1MV86@1224|Proteobacteria,1RNNQ@1236|Gammaproteobacteria,1J7E4@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	aminopeptidases	-	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_M28
HKD2_k127_1750151_29	1122137.AQXF01000004_gene1615	5.101e-13	76.0	COG0558@1|root,COG0558@2|Bacteria,1QX4I@1224|Proteobacteria,2TZ8N@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1750151_25	1122604.JONR01000003_gene1417	1.611e-27	113.0	2E9H4@1|root,333Q5@2|Bacteria,1N6SM@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1750151_30	216596.RL1102	0.0001629	52.0	COG1637@1|root,COG3586@1|root,COG1637@2|Bacteria,COG3586@2|Bacteria,1R4TU@1224|Proteobacteria,2U1HP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1750151_19	1142394.PSMK_30020	4.602e-61	226.0	COG1192@1|root,COG3170@1|root,COG1192@2|Bacteria,COG3170@2|Bacteria	2|Bacteria	NU	translation initiation factor activity	soj	GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0008150,GO:0009295,GO:0016020,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044424,GO:0044464,GO:0071944	-	ko:K03496,ko:K09000	-	-	-	-	ko00000,ko02048,ko03036,ko04812	-	-	-	AAA_31
HKD2_k127_1765021_2	1448389.BAVQ01000070_gene2142	2.735e-74	259.0	COG1024@1|root,COG1024@2|Bacteria,2GNXD@201174|Actinobacteria	201174|Actinobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	4.2.1.17	ko:K01692	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
HKD2_k127_1765021_1	1448389.BAVQ01000070_gene2141	2.81e-151	499.0	COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria	201174|Actinobacteria	IQ	PFAM AMP-dependent synthetase and ligase	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
HKD2_k127_1765021_7	349124.Hhal_1175	1.251e-14	84.0	COG3071@1|root,COG3071@2|Bacteria,1N6Y8@1224|Proteobacteria	1224|Proteobacteria	H	Protein of unknown function (DUF2905)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2905
HKD2_k127_1765021_8	1333856.L686_07245	4.222e-12	74.0	COG0622@1|root,COG0622@2|Bacteria,1RGUN@1224|Proteobacteria,1S69D@1236|Gammaproteobacteria,1Z0QQ@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	S	Phosphoesterase	-	-	-	ko:K07095	-	-	-	-	ko00000	-	-	-	Metallophos_2
HKD2_k127_1765021_6	765911.Thivi_0085	3.897e-17	87.0	COG0589@1|root,COG0589@2|Bacteria,1N8EJ@1224|Proteobacteria,1SEEB@1236|Gammaproteobacteria,1WZHH@135613|Chromatiales	135613|Chromatiales	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD2_k127_1765021_4	582744.Msip34_1757	6.015e-68	239.0	2C8XG@1|root,2Z7PK@2|Bacteria,1RA5I@1224|Proteobacteria,2VQGY@28216|Betaproteobacteria,2KKNU@206350|Nitrosomonadales	206350|Nitrosomonadales	S	Protein of unknown function (DUF4197)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4197
HKD2_k127_1765021_5	1121396.KB892916_gene74	3.228e-37	156.0	2CM5J@1|root,33NXS@2|Bacteria,1NHWC@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1765021_3	1123247.AUIJ01000041_gene300	4.162e-72	254.0	COG0500@1|root,COG2226@2|Bacteria,1PPKI@1224|Proteobacteria,2TRIB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25,Methyltransf_31
HKD2_k127_1765021_0	266117.Rxyl_1929	1.497e-248	793.0	COG1067@1|root,COG1067@2|Bacteria,2H2TE@201174|Actinobacteria	201174|Actinobacteria	O	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_32,Lon_C
HKD2_k127_1770029_0	1123073.KB899241_gene2002	6.529e-165	531.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1X3DA@135614|Xanthomonadales	135614|Xanthomonadales	T	Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains	pilR	-	-	ko:K02667	ko02020,map02020	M00501	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD2_k127_1770029_2	1292034.OR37_02184	1.118e-15	85.0	COG2246@1|root,COG2246@2|Bacteria,1N87E@1224|Proteobacteria,2UHWZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	GtrA-like protein	-	-	-	-	-	-	-	-	-	-	-	-	GtrA
HKD2_k127_1770029_1	1523503.JPMY01000010_gene2722	3.183e-20	93.0	COG0642@1|root,COG2205@2|Bacteria,1MXF8@1224|Proteobacteria,1RMMI@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Histidine kinase	pilS	-	2.7.13.3	ko:K02668	ko02020,map02020	M00501	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	HATPase_c,HisKA,PAS_8
HKD2_k127_1840645_4	342113.DM82_3521	3.442e-76	266.0	COG1512@1|root,COG1512@2|Bacteria,1PB41@1224|Proteobacteria,2VMNV@28216|Betaproteobacteria,1K55Q@119060|Burkholderiaceae	28216|Betaproteobacteria	S	TPM domain	-	-	-	ko:K06872	-	-	-	-	ko00000	-	-	-	TPM_phosphatase
HKD2_k127_1840645_3	666684.AfiDRAFT_0638	2.065e-79	279.0	COG1704@1|root,COG1704@2|Bacteria,1MVH0@1224|Proteobacteria,2TRJR@28211|Alphaproteobacteria,3JTSH@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	LemA family	lemA	-	-	ko:K03744	-	-	-	-	ko00000	-	-	-	LemA
HKD2_k127_1840645_5	398767.Glov_0563	6.08e-74	266.0	COG0500@1|root,COG2226@2|Bacteria,1RFPW@1224|Proteobacteria	1224|Proteobacteria	Q	Methyl-transferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
HKD2_k127_1840645_9	1379270.AUXF01000004_gene2945	7.452e-25	111.0	2E3B5@1|root,32YAP@2|Bacteria,1ZUWQ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Protein of unknown function (DUF2721)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2721
HKD2_k127_1840645_6	349521.HCH_00585	1.93e-61	216.0	COG0782@1|root,COG0782@2|Bacteria,1RAP0@1224|Proteobacteria,1S40Q@1236|Gammaproteobacteria,1XJZG@135619|Oceanospirillales	135619|Oceanospirillales	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreB releases sequences of up to 9 nucleotides in length	greB	-	-	ko:K04760	-	-	-	-	ko00000,ko03021	-	-	-	GreA_GreB,GreA_GreB_N
HKD2_k127_1840645_8	1385517.N800_12720	1.205e-40	160.0	COG3791@1|root,COG3791@2|Bacteria,1N031@1224|Proteobacteria,1S69Q@1236|Gammaproteobacteria,1X8MY@135614|Xanthomonadales	135614|Xanthomonadales	S	Glutathione-dependent formaldehyde-activating enzyme	-	-	-	-	-	-	-	-	-	-	-	-	GFA
HKD2_k127_1840645_0	414684.RC1_1718	6.152e-231	722.0	COG5310@1|root,COG5310@2|Bacteria,1MUZB@1224|Proteobacteria,2TRTR@28211|Alphaproteobacteria,2JR46@204441|Rhodospirillales	204441|Rhodospirillales	Q	Homospermidine synthase	hss	-	2.5.1.44	ko:K00808	ko00960,ko01110,map00960,map01110	-	R00018	RC00053	ko00000,ko00001,ko01000	-	-	-	Sacchrp_dh_C,Sacchrp_dh_NADP
HKD2_k127_1840645_7	1254432.SCE1572_32740	1.151e-59	213.0	COG0625@1|root,COG3631@1|root,COG0625@2|Bacteria,COG3631@2|Bacteria,1N3UG@1224|Proteobacteria	1224|Proteobacteria	O	Glutathione S-transferase, N-terminal domain	-	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C,GST_C_2,GST_N_3
HKD2_k127_1840645_2	292.DM42_4180	6.47e-90	304.0	COG2897@1|root,COG2897@2|Bacteria,1MW4B@1224|Proteobacteria,2VHAX@28216|Betaproteobacteria,1K2GD@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Sulfurtransferase	sseA	-	2.8.1.1,2.8.1.2	ko:K01011	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko01000	-	-	-	Rhodanese
HKD2_k127_1840645_1	1123508.JH636444_gene5461	2.923e-94	329.0	COG1166@1|root,COG1166@2|Bacteria,2IX6P@203682|Planctomycetes	203682|Planctomycetes	H	Catalyzes the biosynthesis of agmatine from arginine	speA	-	4.1.1.19	ko:K01585	ko00330,ko01100,map00330,map01100	M00133	R00566	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N
HKD2_k127_1918131_0	1122951.ATUE01000008_gene215	0.0	1118.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,3NJS6@468|Moraxellaceae	1236|Gammaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
HKD2_k127_1918131_6	1123257.AUFV01000025_gene3200	1.592e-71	267.0	COG0845@1|root,COG0845@2|Bacteria,1R443@1224|Proteobacteria,1S3AT@1236|Gammaproteobacteria,1X6AV@135614|Xanthomonadales	135614|Xanthomonadales	M	Biotin-lipoyl like	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_D23
HKD2_k127_1918131_7	1122603.ATVI01000008_gene2319	5.179e-70	256.0	COG1538@1|root,COG1538@2|Bacteria,1QNF2@1224|Proteobacteria,1S00R@1236|Gammaproteobacteria,1X3MJ@135614|Xanthomonadales	135614|Xanthomonadales	MU	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
HKD2_k127_1918131_11	1123261.AXDW01000009_gene173	8.362e-55	199.0	COG1309@1|root,COG1309@2|Bacteria,1R7QV@1224|Proteobacteria,1S8ES@1236|Gammaproteobacteria,1X76F@135614|Xanthomonadales	135614|Xanthomonadales	K	WHG domain	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N,WHG
HKD2_k127_1918131_12	530564.Psta_1613	4.265e-53	193.0	COG0783@1|root,COG0783@2|Bacteria,2IZJP@203682|Planctomycetes	203682|Planctomycetes	P	Belongs to the Dps family	-	-	-	ko:K04047	-	-	-	-	ko00000,ko03036	-	-	-	Ferritin
HKD2_k127_1918131_4	1005048.CFU_2845	4.179e-114	386.0	COG0387@1|root,COG0387@2|Bacteria,1MWD8@1224|Proteobacteria,2VJQM@28216|Betaproteobacteria,472ZQ@75682|Oxalobacteraceae	28216|Betaproteobacteria	P	Sodium/calcium exchanger protein	chaA	-	-	ko:K07300	-	-	-	-	ko00000,ko02000	2.A.19	-	-	Na_Ca_ex
HKD2_k127_1918131_2	1260251.SPISAL_01180	1.667e-168	554.0	COG0475@1|root,COG1226@1|root,COG3273@1|root,COG0475@2|Bacteria,COG1226@2|Bacteria,COG3273@2|Bacteria,1MV34@1224|Proteobacteria,1RNVR@1236|Gammaproteobacteria,1WX9W@135613|Chromatiales	135613|Chromatiales	P	Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family	-	-	-	ko:K03455	-	-	-	-	ko00000	2.A.37	-	-	Na_H_Exchanger,TrkA_C,TrkA_N
HKD2_k127_1918131_8	766499.C357_21122	1.184e-69	254.0	COG0767@1|root,COG0767@2|Bacteria,1MVPN@1224|Proteobacteria,2TSGS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	ABC-type transport system involved in resistance to organic solvents permease component	MA20_08115	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE,STAS,STAS_2
HKD2_k127_1918131_5	1323663.AROI01000006_gene2974	6.443e-83	294.0	COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,1RQVA@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	(ABC) transporter	mkl	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
HKD2_k127_1918131_15	107636.JQNK01000008_gene3849	1.635e-35	149.0	COG1463@1|root,COG1463@2|Bacteria,1MU4B@1224|Proteobacteria,2U1JN@28211|Alphaproteobacteria,36YDD@31993|Methylocystaceae	28211|Alphaproteobacteria	Q	MlaD protein	MA20_08125	-	-	ko:K02067	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaD
HKD2_k127_1918131_18	1175306.GWL_22380	4.438e-14	81.0	COG3218@1|root,COG3218@2|Bacteria,1RGW3@1224|Proteobacteria,2VTGZ@28216|Betaproteobacteria	28216|Betaproteobacteria	S	transport system, auxiliary component	-	-	-	ko:K18480	-	M00669	-	-	ko00000,ko00002,ko02000	3.A.1.27.1	-	-	ABC_trans_aux
HKD2_k127_1918131_14	1121013.P873_10985	2.144e-51	194.0	COG0789@1|root,COG0789@2|Bacteria,1R9SN@1224|Proteobacteria,1SFN0@1236|Gammaproteobacteria,1X7VP@135614|Xanthomonadales	135614|Xanthomonadales	K	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,B12-binding_2,MerR_1
HKD2_k127_1918131_3	243365.CV_0542	1.583e-125	428.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,2KQJ6@206351|Neisseriales	206351|Neisseriales	T	signal transduction protein containing a membrane domain, an EAL and a GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS_9,dCache_2
HKD2_k127_1918131_10	1120980.JQKH01000043_gene1301	3.427e-63	225.0	COG1876@1|root,COG1876@2|Bacteria,1N2IC@1224|Proteobacteria,2VTBI@28216|Betaproteobacteria	28216|Betaproteobacteria	M	D-alanyl-D-alanine carboxypeptidase	-	-	-	-	-	-	-	-	-	-	-	-	VanY
HKD2_k127_1918131_13	96561.Dole_0115	1.266e-52	196.0	COG4221@1|root,COG4221@2|Bacteria,1QVS5@1224|Proteobacteria,42PP2@68525|delta/epsilon subdivisions,2WMHE@28221|Deltaproteobacteria,2MJAG@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HKD2_k127_1918131_16	1123073.KB899242_gene892	2.322e-33	135.0	COG1226@1|root,31669@2|Bacteria,1RIW0@1224|Proteobacteria,1S6HC@1236|Gammaproteobacteria,1X7X2@135614|Xanthomonadales	135614|Xanthomonadales	P	Ion channel	-	-	-	-	-	-	-	-	-	-	-	-	Ion_trans_2
HKD2_k127_1918131_17	1472716.KBK24_0118485	1.737e-25	108.0	2E35S@1|root,32Y5P@2|Bacteria,1N6WS@1224|Proteobacteria,2VX2T@28216|Betaproteobacteria,1K8JC@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Putative prokaryotic signal transducing protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF2007
HKD2_k127_1918131_9	1121935.AQXX01000131_gene2792	2.355e-66	236.0	COG0824@1|root,COG0824@2|Bacteria,1R6A6@1224|Proteobacteria	1224|Proteobacteria	S	Thioesterase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1918131_1	396588.Tgr7_0061	3.984e-192	611.0	COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,1RNQM@1236|Gammaproteobacteria,1WWEC@135613|Chromatiales	135613|Chromatiales	S	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis	ubiB	-	-	ko:K03688	-	-	-	-	ko00000	-	-	-	ABC1
HKD2_k127_196183_36	1267533.KB906733_gene3300	3.518e-13	82.0	COG1807@1|root,COG1807@2|Bacteria,3Y4VS@57723|Acidobacteria,2JK41@204432|Acidobacteriia	204432|Acidobacteriia	M	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HKD2_k127_196183_21	1157708.KB907450_gene5213	2.917e-89	303.0	COG4291@1|root,COG4291@2|Bacteria,1RGUF@1224|Proteobacteria,2VQ2N@28216|Betaproteobacteria,4ADNG@80864|Comamonadaceae	28216|Betaproteobacteria	S	Protein of unknown function (DUF1345)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1345
HKD2_k127_196183_2	1187851.A33M_3475	9.563e-268	833.0	COG0033@1|root,COG0033@2|Bacteria,1MU5S@1224|Proteobacteria,2TRUJ@28211|Alphaproteobacteria,3FDI8@34008|Rhodovulum	28211|Alphaproteobacteria	G	Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III	pgm	-	5.4.2.2	ko:K01835	ko00010,ko00030,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00549	R00959,R01057,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
HKD2_k127_196183_14	1449076.JOOE01000001_gene2245	8.867e-126	420.0	COG3104@1|root,COG3104@2|Bacteria,1MW6W@1224|Proteobacteria,2U15C@28211|Alphaproteobacteria,2K2WX@204457|Sphingomonadales	204457|Sphingomonadales	E	amino acid peptide transporter	-	-	-	ko:K03305	-	-	-	-	ko00000	2.A.17	-	-	PTR2
HKD2_k127_196183_7	1266925.JHVX01000005_gene1919	7.293e-175	554.0	COG0463@1|root,COG2246@1|root,COG0463@2|Bacteria,COG2246@2|Bacteria,1MV8J@1224|Proteobacteria,2W9NC@28216|Betaproteobacteria,3726J@32003|Nitrosomonadales	28216|Betaproteobacteria	M	GtrA-like protein	-	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2,GtrA
HKD2_k127_196183_35	1294265.JCM21738_884	1.721e-20	105.0	2DS7Z@1|root,33EXN@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	GT87
HKD2_k127_196183_8	933262.AXAM01000047_gene2343	2.338e-172	557.0	COG2252@1|root,COG2252@2|Bacteria,1MUV0@1224|Proteobacteria,42MAE@68525|delta/epsilon subdivisions,2WKFF@28221|Deltaproteobacteria,2MKCJ@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Permease family	pbuG	-	-	ko:K06901	-	-	-	-	ko00000,ko02000	2.A.1.40	-	-	Xan_ur_permease
HKD2_k127_196183_17	420662.Mpe_A0677	1.293e-99	329.0	COG1028@1|root,COG1028@2|Bacteria,1QKCK@1224|Proteobacteria,2VN0G@28216|Betaproteobacteria	28216|Betaproteobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HKD2_k127_196183_6	216595.PFLU_1208	3.028e-207	662.0	COG1232@1|root,COG1232@2|Bacteria,1QTUF@1224|Proteobacteria,1T1HM@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	NAD(P)-binding Rossmann-like domain	spdH	-	1.5.99.6	ko:K00316	ko00330,ko00410,ko01100,map00330,map00410,map01100	-	R01914,R01915	RC00053,RC00225	ko00000,ko00001,ko01000	-	-	-	NAD_binding_8
HKD2_k127_196183_30	1000565.METUNv1_03434	6.002e-32	139.0	COG2259@1|root,COG2259@2|Bacteria,1N1VA@1224|Proteobacteria,2VU9I@28216|Betaproteobacteria,2KZF6@206389|Rhodocyclales	206389|Rhodocyclales	S	DoxX	-	-	-	-	-	-	-	-	-	-	-	-	DoxX
HKD2_k127_196183_33	1159870.KB907784_gene3361	3.048e-24	113.0	COG3219@1|root,COG3219@2|Bacteria,1QAP4@1224|Proteobacteria,2VXJI@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Putative DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF2063
HKD2_k127_196183_20	1163409.UUA_09661	1.582e-89	307.0	COG3220@1|root,COG3220@2|Bacteria,1MURE@1224|Proteobacteria,1RQ9H@1236|Gammaproteobacteria,1X35S@135614|Xanthomonadales	135614|Xanthomonadales	S	Belongs to the UPF0276 family	-	-	-	ko:K09930	-	-	-	-	ko00000	-	-	-	DUF692
HKD2_k127_196183_34	402626.Rpic_4292	3.572e-23	104.0	COG5572@1|root,COG5572@2|Bacteria,1MZ6Q@1224|Proteobacteria,2VWC8@28216|Betaproteobacteria,1K9JZ@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Predicted integral membrane protein (DUF2282)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2282
HKD2_k127_196183_29	1232683.ADIMK_3435	1.791e-32	132.0	COG4103@1|root,COG4103@2|Bacteria,1N6YZ@1224|Proteobacteria,1SD1K@1236|Gammaproteobacteria,468DI@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	TerB
HKD2_k127_196183_27	204669.Acid345_3020	6.78e-49	184.0	COG2834@1|root,COG2834@2|Bacteria,3Y7NW@57723|Acidobacteria	57723|Acidobacteria	M	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_196183_0	1248916.ANFY01000009_gene99	0.0	1255.0	COG4447@1|root,COG4447@2|Bacteria,1ND1J@1224|Proteobacteria,2U0UY@28211|Alphaproteobacteria,2KDZF@204457|Sphingomonadales	204457|Sphingomonadales	S	Sortilin, neurotensin receptor 3,	-	-	-	-	-	-	-	-	-	-	-	-	Sortilin-Vps10
HKD2_k127_196183_24	713586.KB900536_gene2316	1.008e-72	253.0	COG1192@1|root,COG1192@2|Bacteria,1QBJX@1224|Proteobacteria,1S739@1236|Gammaproteobacteria	1236|Gammaproteobacteria	D	involved in chromosome partitioning	-	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31,CbiA
HKD2_k127_196183_32	1042377.AFPJ01000042_gene1071	2.006e-26	117.0	COG2068@1|root,COG2068@2|Bacteria,1MW0X@1224|Proteobacteria,1SEGZ@1236|Gammaproteobacteria,46D23@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	MobA-like NTP transferase domain	mocA	-	2.7.7.76	ko:K07141	ko00790,map00790	-	R11582	-	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
HKD2_k127_196183_1	309807.SRU_0691	5.196e-276	874.0	COG0460@1|root,COG0527@1|root,COG0460@2|Bacteria,COG0527@2|Bacteria,4NFGR@976|Bacteroidetes,1FIND@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	E	homoserine dehydrogenase	-	-	1.1.1.3,2.7.2.4	ko:K12524	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00017,M00018,M00526,M00527	R00480,R01773,R01775	RC00002,RC00043,RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT_7,Homoserine_dh,NAD_binding_3
HKD2_k127_196183_22	1131451.O1K_18273	2.983e-85	297.0	COG0083@1|root,COG0083@2|Bacteria,1MW8I@1224|Proteobacteria,1RMYR@1236|Gammaproteobacteria,1X3BS@135614|Xanthomonadales	135614|Xanthomonadales	E	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate	thrB	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004413,GO:0006082,GO:0006520,GO:0006555,GO:0006566,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009088,GO:0009092,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019202,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.1.39	ko:K00872	ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230	M00018	R01771	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
HKD2_k127_196183_10	1163407.UU7_12334	1.206e-139	460.0	COG0498@1|root,COG0498@2|Bacteria,1MUWQ@1224|Proteobacteria,1RQ0H@1236|Gammaproteobacteria,1X541@135614|Xanthomonadales	135614|Xanthomonadales	E	Threonine synthase	thrC	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP,Thr_synth_N
HKD2_k127_196183_37	765912.Thimo_2257	3.418e-09	69.0	COG0551@1|root,COG0551@2|Bacteria,1PZFI@1224|Proteobacteria,1RQ64@1236|Gammaproteobacteria,1WXVE@135613|Chromatiales	135613|Chromatiales	L	NERD domain protein	-	-	-	-	-	-	-	-	-	-	-	-	NERD,zf-C4_Topoisom
HKD2_k127_196183_5	1121013.P873_04860	3.652e-211	665.0	COG0624@1|root,COG0624@2|Bacteria,1MW20@1224|Proteobacteria,1RPN7@1236|Gammaproteobacteria,1X4BQ@135614|Xanthomonadales	135614|Xanthomonadales	E	peptidase M20	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
HKD2_k127_196183_19	1123253.AUBD01000004_gene1067	9.273e-92	317.0	COG0084@1|root,COG0084@2|Bacteria,1MXN8@1224|Proteobacteria,1RNCC@1236|Gammaproteobacteria,1X3N8@135614|Xanthomonadales	135614|Xanthomonadales	L	Preprotein translocase subunit TatD	tatD	-	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
HKD2_k127_196183_28	319225.Plut_0661	2.059e-41	162.0	COG1451@1|root,COG1451@2|Bacteria,1FE2Z@1090|Chlorobi	1090|Chlorobi	S	WLM domain	-	-	-	ko:K07043	-	-	-	-	ko00000	-	-	-	DUF45
HKD2_k127_196183_9	1122211.JMLW01000005_gene532	1.112e-148	478.0	COG0722@1|root,COG0722@2|Bacteria,1MU5Q@1224|Proteobacteria,1RMAA@1236|Gammaproteobacteria,1XHH6@135619|Oceanospirillales	135619|Oceanospirillales	E	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)	aroF-1	-	2.5.1.54	ko:K01626	ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_1
HKD2_k127_196183_4	365046.Rta_18440	1.467e-220	693.0	COG0044@1|root,COG0044@2|Bacteria,1MW10@1224|Proteobacteria,2VJZV@28216|Betaproteobacteria,4ABSY@80864|Comamonadaceae	28216|Betaproteobacteria	F	PFAM amidohydrolase	-	-	3.5.2.2,3.5.2.5	ko:K01464,ko:K01466	ko00230,ko00240,ko00410,ko00770,ko00983,ko01100,ko01120,map00230,map00240,map00410,map00770,map00983,map01100,map01120	M00046,M00546	R02269,R02425,R03055,R08227	RC00632,RC00680	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Amidohydro_1
HKD2_k127_196183_3	59538.XP_005967211.1	6.726e-234	775.0	COG0308@1|root,KOG1046@2759|Eukaryota,38CFG@33154|Opisthokonta,3BADC@33208|Metazoa,3CW5S@33213|Bilateria,486H0@7711|Chordata,48VUN@7742|Vertebrata,3JCRF@40674|Mammalia,4IYGI@91561|Cetartiodactyla	33208|Metazoa	EO	Aminopeptidase puromycin sensitive	-	-	-	-	-	-	-	-	-	-	-	-	ERAP1_C,Peptidase_M1
HKD2_k127_196183_25	394221.Mmar10_2222	3.553e-65	226.0	COG0678@1|root,COG0678@2|Bacteria,1MU0H@1224|Proteobacteria,2U6ZN@28211|Alphaproteobacteria,43XJN@69657|Hyphomonadaceae	28211|Alphaproteobacteria	O	Peroxiredoxin	MA20_20905	-	1.11.1.15	ko:K03386	ko04214,map04214	-	-	-	ko00000,ko00001,ko01000,ko04147	-	-	-	Redoxin
HKD2_k127_196183_16	1397666.RS24_00308	4.051e-102	342.0	COG2130@1|root,COG2130@2|Bacteria,1MUC2@1224|Proteobacteria,2TQYM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	NADP-dependent oxidoreductase	-	-	-	ko:K07119	-	-	-	-	ko00000	-	-	-	ADH_N_2,ADH_zinc_N
HKD2_k127_196183_15	629773.AORY01000012_gene833	5.328e-106	365.0	COG0596@1|root,COG0596@2|Bacteria,1QJMR@1224|Proteobacteria,2TUSH@28211|Alphaproteobacteria,2K6PA@204457|Sphingomonadales	204457|Sphingomonadales	S	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_196183_12	522373.Smlt0645	1.147e-133	432.0	COG2025@1|root,COG2025@2|Bacteria,1MUFI@1224|Proteobacteria,1RMK7@1236|Gammaproteobacteria,1X4RW@135614|Xanthomonadales	135614|Xanthomonadales	C	Electron transfer flavoprotein	etfA	-	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	-	ETF,ETF_alpha
HKD2_k127_196183_18	1123073.KB899241_gene2069	7.93e-99	329.0	COG2086@1|root,COG2086@2|Bacteria,1MVH6@1224|Proteobacteria,1RN6F@1236|Gammaproteobacteria,1X34D@135614|Xanthomonadales	135614|Xanthomonadales	C	electron transfer flavoprotein beta subunit	etfB	-	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
HKD2_k127_196183_13	383372.Rcas_3505	1.532e-130	427.0	COG0388@1|root,COG0388@2|Bacteria	2|Bacteria	S	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	-	-	-	-	-	-	-	-	-	-	-	-	CN_hydrolase
HKD2_k127_196183_26	396588.Tgr7_1078	8.873e-56	216.0	COG1162@1|root,COG1162@2|Bacteria,1MUEF@1224|Proteobacteria,1RMMB@1236|Gammaproteobacteria,1WW4C@135613|Chromatiales	135613|Chromatiales	S	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit	rsgA	-	3.1.3.100	ko:K06949	ko00730,ko01100,map00730,map01100	-	R00615,R02135	RC00002,RC00017	ko00000,ko00001,ko01000,ko03009	-	-	-	RsgA_GTPase
HKD2_k127_196183_11	1123399.AQVE01000001_gene559	1.937e-135	443.0	COG0501@1|root,COG0501@2|Bacteria,1MUXT@1224|Proteobacteria,1RNKP@1236|Gammaproteobacteria,45ZWZ@72273|Thiotrichales	72273|Thiotrichales	O	PFAM Peptidase family M48	-	-	3.4.24.84	ko:K06013	ko00900,ko01130,map00900,map01130	-	R09845	RC00141	ko00000,ko00001,ko01000,ko01002,ko04147	-	-	-	Peptidase_M48,Peptidase_M48_N
HKD2_k127_196183_23	1168065.DOK_11394	4.568e-79	269.0	COG1949@1|root,COG1949@2|Bacteria,1R9WX@1224|Proteobacteria,1S217@1236|Gammaproteobacteria,1J5R2@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	A	3'-to-5' exoribonuclease specific for small oligoribonucleotides	orn	GO:0000175,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004532,GO:0004536,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008296,GO:0008297,GO:0008310,GO:0008408,GO:0008946,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0016896,GO:0019439,GO:0034611,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0140097,GO:0140098,GO:1901360,GO:1901361,GO:1901575	-	ko:K13288	ko03008,map03008	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019	-	-	-	RNase_T
HKD2_k127_2119928_1	572477.Alvin_0325	1.201e-296	920.0	COG3808@1|root,COG3808@2|Bacteria,1MUQ3@1224|Proteobacteria,1RN4K@1236|Gammaproteobacteria,1WVYF@135613|Chromatiales	135613|Chromatiales	C	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
HKD2_k127_2119928_4	472759.Nhal_0506	6.158e-211	662.0	COG0205@1|root,COG0205@2|Bacteria,1MVN3@1224|Proteobacteria,1RMVY@1236|Gammaproteobacteria,1WWG7@135613|Chromatiales	135613|Chromatiales	G	Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions	pfp	-	2.7.1.11,2.7.1.90	ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
HKD2_k127_2119928_22	472759.Nhal_0505	8.619e-74	258.0	COG0563@1|root,COG0563@2|Bacteria,1MXCZ@1224|Proteobacteria,1RMT6@1236|Gammaproteobacteria,1WX43@135613|Chromatiales	135613|Chromatiales	F	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism	adk	-	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ADK,ADK_lid
HKD2_k127_2119928_20	519989.ECTPHS_09233	6.274e-80	280.0	COG0349@1|root,COG0349@2|Bacteria,1MURV@1224|Proteobacteria,1RPBP@1236|Gammaproteobacteria,1WZ40@135613|Chromatiales	135613|Chromatiales	J	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides	rnd	-	3.1.13.5	ko:K03684	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DNA_pol_A_exo1,HRDC
HKD2_k127_2119928_35	765910.MARPU_12625	1.696e-14	81.0	2952G@1|root,2ZSF9@2|Bacteria,1NFKJ@1224|Proteobacteria,1S5Q0@1236|Gammaproteobacteria,1WY9R@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2119928_10	987059.RBXJA2T_12142	6.205e-179	580.0	COG0773@1|root,COG0773@2|Bacteria,1MUC5@1224|Proteobacteria,2VIX5@28216|Betaproteobacteria,1KJCV@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	Reutilizes the intact tripeptide L-alanyl-gamma-D- glutamyl-meso-diaminopimelate by linking it to UDP-N- acetylmuramate	mpl	-	6.3.2.45	ko:K02558	-	-	-	-	ko00000,ko01000	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
HKD2_k127_2119928_25	396588.Tgr7_2427	7.343e-56	202.0	COG2802@1|root,COG2802@2|Bacteria,1NV9N@1224|Proteobacteria,1SAAZ@1236|Gammaproteobacteria,1WXGU@135613|Chromatiales	135613|Chromatiales	S	peptidase S16, lon	-	-	-	ko:K07157	-	-	-	-	ko00000	-	-	-	LON_substr_bdg
HKD2_k127_2119928_33	701176.VIBRN418_07975	5.149e-17	90.0	2EGR5@1|root,33AHA@2|Bacteria,1NH3C@1224|Proteobacteria,1SIE7@1236|Gammaproteobacteria,1XYWX@135623|Vibrionales	135623|Vibrionales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2119928_28	1216007.AOPM01000102_gene736	1.161e-52	199.0	COG1819@1|root,COG1819@2|Bacteria,1PJJ9@1224|Proteobacteria,1S07B@1236|Gammaproteobacteria,2PZVX@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	CG	glycosyl	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2119928_8	1049564.TevJSym_as00140	1.461e-191	610.0	COG0001@1|root,COG0001@2|Bacteria,1MUY5@1224|Proteobacteria,1RM7N@1236|Gammaproteobacteria,1J53B@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	H	Aminotransferase	hemL	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016853,GO:0016866,GO:0016869,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042286,GO:0042440,GO:0042802,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0046501,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	iUMNK88_1353.UMNK88_158	Aminotran_3
HKD2_k127_2119928_27	292564.Cyagr_3419	3.21e-54	209.0	COG3735@1|root,COG3735@2|Bacteria,1G6DE@1117|Cyanobacteria,22TCH@167375|Cyanobium	1117|Cyanobacteria	S	TraB family	-	-	-	ko:K09973	-	-	-	-	ko00000	-	-	-	TraB
HKD2_k127_2119928_29	1177154.Y5S_01631	5.454e-44	169.0	COG1409@1|root,COG1409@2|Bacteria,1MWKX@1224|Proteobacteria,1RPA7@1236|Gammaproteobacteria,1XJ9U@135619|Oceanospirillales	135619|Oceanospirillales	S	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes	cpdA	-	3.1.4.53	ko:K03651	ko00230,ko02025,map00230,map02025	-	R00191	RC00296	ko00000,ko00001,ko01000	-	-	-	Metallophos
HKD2_k127_2119928_38	1303518.CCALI_00587	0.0004005	51.0	COG3000@1|root,COG3000@2|Bacteria	2|Bacteria	I	iron ion binding	-	-	-	-	-	-	-	-	-	-	-	-	FA_hydroxylase,Polyketide_cyc2
HKD2_k127_2119928_2	519989.ECTPHS_03834	1.664e-254	790.0	COG0499@1|root,COG0499@2|Bacteria,1MUQ2@1224|Proteobacteria,1RMW8@1236|Gammaproteobacteria,1WVY5@135613|Chromatiales	135613|Chromatiales	H	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine	ahcY	-	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
HKD2_k127_2119928_3	1149133.ppKF707_3230	9.622e-216	674.0	COG0192@1|root,COG0192@2|Bacteria,1MUFQ@1224|Proteobacteria,1RNV6@1236|Gammaproteobacteria,1YDX4@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	H	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme	metK	GO:0000096,GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004478,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006556,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009066,GO:0009069,GO:0009108,GO:0009116,GO:0009119,GO:0009987,GO:0016740,GO:0016765,GO:0017076,GO:0017144,GO:0019752,GO:0030554,GO:0030955,GO:0031420,GO:0032553,GO:0032555,GO:0032559,GO:0033353,GO:0034641,GO:0035639,GO:0036094,GO:0042278,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0046872,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0097159,GO:0097367,GO:1901135,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901576,GO:1901605,GO:1901657	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	iJN746.PP_4967,iYL1228.KPN_03375	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
HKD2_k127_2119928_0	519989.ECTPHS_09692	3.023e-307	954.0	COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,1RMWP@1236|Gammaproteobacteria,1WVWH@135613|Chromatiales	135613|Chromatiales	G	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
HKD2_k127_2119928_5	987059.RBXJA2T_02647	2.509e-201	629.0	COG0057@1|root,COG0057@2|Bacteria,1MU93@1224|Proteobacteria,2VHHG@28216|Betaproteobacteria,1KKA5@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family	gapA	GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0036094,GO:0043891,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0097159,GO:1901265,GO:1901363	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Gp_dh_C,Gp_dh_N
HKD2_k127_2119928_11	396588.Tgr7_2891	8.048e-164	528.0	COG0126@1|root,COG0126@2|Bacteria,1MUNU@1224|Proteobacteria,1RMUQ@1236|Gammaproteobacteria,1WX6Z@135613|Chromatiales	135613|Chromatiales	F	Belongs to the phosphoglycerate kinase family	pgk	-	2.7.2.3	ko:K00927	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01512	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
HKD2_k127_2119928_12	187272.Mlg_2843	4.888e-160	519.0	COG0469@1|root,COG0469@2|Bacteria,1MU21@1224|Proteobacteria,1RMW3@1236|Gammaproteobacteria,1WXEF@135613|Chromatiales	135613|Chromatiales	G	Belongs to the pyruvate kinase family	-	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PK,PK_C
HKD2_k127_2119928_14	1123366.TH3_11595	5.71e-141	451.0	COG0714@1|root,COG0714@2|Bacteria,1MV5I@1224|Proteobacteria,2TRI8@28211|Alphaproteobacteria,2JPIE@204441|Rhodospirillales	204441|Rhodospirillales	S	AAA domain (dynein-related subfamily)	-	-	-	-	-	-	-	-	-	-	-	-	AAA,AAA_5
HKD2_k127_2119928_9	1123261.AXDW01000007_gene2232	5.048e-186	589.0	COG3825@1|root,COG3825@2|Bacteria,1MUAJ@1224|Proteobacteria,1RMRY@1236|Gammaproteobacteria,1X4SK@135614|Xanthomonadales	135614|Xanthomonadales	S	protein conserved in bacteria	-	-	-	ko:K09989	-	-	-	-	ko00000	-	-	-	VWA_CoxE
HKD2_k127_2119928_26	1123073.KB899241_gene2821	1.225e-55	201.0	COG1225@1|root,COG1225@2|Bacteria,1RD4R@1224|Proteobacteria,1RQ7F@1236|Gammaproteobacteria,1X6IK@135614|Xanthomonadales	135614|Xanthomonadales	O	Redoxin	-	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
HKD2_k127_2119928_19	85643.Tmz1t_1094	2.068e-90	312.0	COG1752@1|root,COG1752@2|Bacteria,1PIHH@1224|Proteobacteria,2VHKX@28216|Betaproteobacteria,2KUYE@206389|Rhodocyclales	206389|Rhodocyclales	S	esterase of the alpha-beta hydrolase superfamily	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
HKD2_k127_2119928_13	1260251.SPISAL_07030	1.276e-159	514.0	COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,1RNE4@1236|Gammaproteobacteria,1WW0B@135613|Chromatiales	135613|Chromatiales	P	Acts as a magnesium transporter	-	-	-	ko:K06213	-	-	-	-	ko00000,ko02000	1.A.26.1	-	-	CBS,MgtE,MgtE_N
HKD2_k127_2119928_18	1116472.MGMO_55c00170	2.998e-95	319.0	COG1660@1|root,COG1660@2|Bacteria,1MVX6@1224|Proteobacteria,1RNJX@1236|Gammaproteobacteria,1XE9S@135618|Methylococcales	135618|Methylococcales	S	Displays ATPase and GTPase activities	-	-	-	ko:K06958	-	-	-	-	ko00000,ko03019	-	-	-	ATP_bind_2
HKD2_k127_2119928_31	1415779.JOMH01000001_gene2938	1.327e-30	126.0	COG1544@1|root,COG1544@2|Bacteria,1MZHW@1224|Proteobacteria,1S8U1@1236|Gammaproteobacteria,1X7QA@135614|Xanthomonadales	135614|Xanthomonadales	J	modulation protein	raiA	-	-	ko:K05808	-	-	-	-	ko00000,ko03009	-	-	-	Ribosomal_S30AE
HKD2_k127_2119928_16	1158762.KB898044_gene358	5.682e-128	425.0	COG1508@1|root,COG1508@2|Bacteria,1MW4V@1224|Proteobacteria,1RMY0@1236|Gammaproteobacteria,1WVZD@135613|Chromatiales	135613|Chromatiales	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	-	-	-	ko:K03092	ko02020,ko05111,map02020,map05111	-	-	-	ko00000,ko00001,ko03021	-	-	-	Sigma54_AID,Sigma54_CBD,Sigma54_DBD
HKD2_k127_2119928_17	395493.BegalDRAFT_2836	1.126e-104	355.0	COG1137@1|root,COG1137@2|Bacteria,1MU8M@1224|Proteobacteria,1RPW1@1236|Gammaproteobacteria,45ZYJ@72273|Thiotrichales	72273|Thiotrichales	S	ABC transporter, ATP-binding protein	lptB	-	-	ko:K06861	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	1.B.42.1	-	-	ABC_tran,BCA_ABC_TP_C
HKD2_k127_2119928_36	1163409.UUA_02481	1.952e-09	66.0	COG1934@1|root,COG1934@2|Bacteria,1N3J5@1224|Proteobacteria,1SBBI@1236|Gammaproteobacteria,1X7U2@135614|Xanthomonadales	135614|Xanthomonadales	S	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm	lptA	-	-	ko:K09774	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	OstA
HKD2_k127_2119928_37	1384056.N787_12270	3.172e-06	57.0	COG3117@1|root,COG3117@2|Bacteria,1NGCC@1224|Proteobacteria,1SGDP@1236|Gammaproteobacteria,1X75G@135614|Xanthomonadales	135614|Xanthomonadales	S	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. Facilitates the transfer of LPS from the inner membrane to the periplasmic protein LptA. Could be a docking site for LptA	lptC	-	-	ko:K11719	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	LptC
HKD2_k127_2119928_30	243233.MCA0745	9.494e-40	161.0	COG1778@1|root,COG1778@2|Bacteria,1RH85@1224|Proteobacteria,1S6D0@1236|Gammaproteobacteria,1XEYT@135618|Methylococcales	135618|Methylococcales	S	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate	-	-	3.1.3.45	ko:K03270	ko00540,ko01100,map00540,map01100	M00063	R03350	RC00017	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hydrolase_3
HKD2_k127_2119928_15	314278.NB231_05746	5.494e-131	431.0	COG0517@1|root,COG0794@1|root,COG0517@2|Bacteria,COG0794@2|Bacteria,1MUXD@1224|Proteobacteria,1RMT9@1236|Gammaproteobacteria,1WWFJ@135613|Chromatiales	135613|Chromatiales	M	Arabinose 5-phosphate isomerase	-	-	5.3.1.13	ko:K06041	ko00540,ko01100,map00540,map01100	M00063	R01530	RC00541	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CBS,SIS
HKD2_k127_2119928_32	1122236.KB905143_gene25	5.958e-21	94.0	COG5007@1|root,COG5007@2|Bacteria,1MZCZ@1224|Proteobacteria,2VU0K@28216|Betaproteobacteria,2KN4E@206350|Nitrosomonadales	206350|Nitrosomonadales	K	Belongs to the BolA IbaG family	-	-	-	-	-	-	-	-	-	-	-	-	BolA
HKD2_k127_2119928_7	396588.Tgr7_0742	1.314e-195	617.0	COG0766@1|root,COG0766@2|Bacteria,1MUH7@1224|Proteobacteria,1RN91@1236|Gammaproteobacteria,1WXB6@135613|Chromatiales	135613|Chromatiales	M	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine	murA	-	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase
HKD2_k127_2119928_23	228410.NE0809	3.206e-72	248.0	COG0723@1|root,COG0723@2|Bacteria,1RAA2@1224|Proteobacteria,2VK46@28216|Betaproteobacteria,3721J@32003|Nitrosomonadales	28216|Betaproteobacteria	C	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis	petA	-	1.10.2.2	ko:K00411	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002,ko01000	-	-	-	Rieske,UCR_Fe-S_N
HKD2_k127_2119928_6	1123393.KB891316_gene1115	2.174e-196	619.0	COG1290@1|root,COG1290@2|Bacteria,1MV97@1224|Proteobacteria,2VHP5@28216|Betaproteobacteria,1KRDP@119069|Hydrogenophilales	119069|Hydrogenophilales	C	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis	-	-	-	ko:K00412	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002,ko03029	-	-	-	Cytochrom_B_C,Cytochrome_B
HKD2_k127_2119928_21	1049564.TevJSym_ag00070	2.031e-76	263.0	COG2857@1|root,COG2857@2|Bacteria,1QFU2@1224|Proteobacteria,1RN4Y@1236|Gammaproteobacteria,1J7JW@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	Cytochrome C1 family	petC	-	-	ko:K00413	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002	-	-	-	Cytochrom_C1
HKD2_k127_2119928_24	391615.ABSJ01000056_gene1534	8.592e-59	211.0	COG0625@1|root,COG0625@2|Bacteria,1MXJD@1224|Proteobacteria,1RP12@1236|Gammaproteobacteria,1J56A@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	O	COG0625 Glutathione S-transferase	sspA	GO:0001000,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0006950,GO:0008150,GO:0009605,GO:0009889,GO:0009891,GO:0009893,GO:0009991,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0019899,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031667,GO:0042594,GO:0043175,GO:0044424,GO:0044444,GO:0044464,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0070063,GO:0080090,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141	-	ko:K03599	-	-	-	-	ko00000,ko02000,ko03021	1.A.12.3.1	-	-	GST_C,GST_N,GST_N_3
HKD2_k127_2119928_34	1121937.AUHJ01000014_gene2630	9.652e-17	91.0	COG2969@1|root,COG2969@2|Bacteria,1MZ2Q@1224|Proteobacteria,1S8WT@1236|Gammaproteobacteria,467R0@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	COG2969 Stringent starvation protein B	sspB	GO:0000502,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008150,GO:0009376,GO:0009893,GO:0009894,GO:0009896,GO:0010604,GO:0019222,GO:0019899,GO:0031597,GO:0032781,GO:0032991,GO:0042176,GO:0042802,GO:0042803,GO:0043085,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043462,GO:0044093,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0045732,GO:0046983,GO:0048518,GO:0050789,GO:0050790,GO:0051117,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0051336,GO:0051345,GO:0060255,GO:0065007,GO:0065009,GO:0080090,GO:0097159,GO:1901363,GO:1902494,GO:1904949,GO:1905368,GO:1905369,GO:1990904	-	ko:K03600	-	-	-	-	ko00000,ko03021	-	-	-	SspB
HKD2_k127_2144466_12	1280954.HPO_19409	4.941e-07	56.0	COG2801@1|root,COG2801@2|Bacteria,1N207@1224|Proteobacteria,2UEQQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_28,HTH_32,rve,rve_3
HKD2_k127_2144466_13	570952.ATVH01000017_gene1822	0.0005311	42.0	COG2801@1|root,COG2801@2|Bacteria,1NAXT@1224|Proteobacteria,2UVUA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2144466_8	1234364.AMSF01000041_gene20	1.233e-91	312.0	COG0745@1|root,COG0745@2|Bacteria,1N0YI@1224|Proteobacteria,1RPNH@1236|Gammaproteobacteria,1X4VA@135614|Xanthomonadales	135614|Xanthomonadales	T	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	-	-	-	ko:K02483	-	-	-	-	ko00000,ko02022	-	-	-	Response_reg,Trans_reg_C
HKD2_k127_2144466_3	1234364.AMSF01000041_gene19	1.107e-134	445.0	COG4191@1|root,COG4191@2|Bacteria,1QV22@1224|Proteobacteria,1T47Z@1236|Gammaproteobacteria,1X57B@135614|Xanthomonadales	135614|Xanthomonadales	T	Histidine kinase	-	-	2.7.13.3	ko:K07649	ko02020,map02020	M00457	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	2CSK_N,HATPase_c,HisKA
HKD2_k127_2144466_5	666685.R2APBS1_1100	7.002e-127	421.0	COG1538@1|root,COG1538@2|Bacteria,1R4FF@1224|Proteobacteria,1SM23@1236|Gammaproteobacteria,1X4ZS@135614|Xanthomonadales	135614|Xanthomonadales	MU	outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
HKD2_k127_2144466_0	1163409.UUA_18314	1.512e-148	482.0	COG0577@1|root,COG0577@2|Bacteria,1NWI3@1224|Proteobacteria,1S023@1236|Gammaproteobacteria,1X5AC@135614|Xanthomonadales	135614|Xanthomonadales	V	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HKD2_k127_2144466_7	1234364.AMSF01000071_gene1747	1.196e-100	341.0	COG1136@1|root,COG1136@2|Bacteria,1QT8W@1224|Proteobacteria,1S43H@1236|Gammaproteobacteria,1X401@135614|Xanthomonadales	135614|Xanthomonadales	V	abc transporter atp-binding protein	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD2_k127_2144466_9	1234364.AMSF01000071_gene1748	1.181e-73	258.0	COG0845@1|root,COG0845@2|Bacteria,1R71G@1224|Proteobacteria,1SFIV@1236|Gammaproteobacteria,1X6RW@135614|Xanthomonadales	135614|Xanthomonadales	M	Secretion protein	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_3
HKD2_k127_2144466_6	666685.R2APBS1_1096	5.295e-126	409.0	COG1647@1|root,COG1647@2|Bacteria,1MVZP@1224|Proteobacteria,1RXZI@1236|Gammaproteobacteria,1X4ZB@135614|Xanthomonadales	135614|Xanthomonadales	S	Esterase lipase	-	-	3.1.1.1	ko:K03928	-	-	-	-	ko00000,ko01000	-	-	-	Hydrolase_4
HKD2_k127_2144466_11	666685.R2APBS1_1095	2.743e-42	161.0	2DA9N@1|root,32TUZ@2|Bacteria,1QVBT@1224|Proteobacteria,1S8UR@1236|Gammaproteobacteria,1XD95@135614|Xanthomonadales	135614|Xanthomonadales	S	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HKD2_k127_2144466_10	1163409.UUA_03628	1.72e-47	181.0	COG0697@1|root,COG0697@2|Bacteria,1RHK2@1224|Proteobacteria,1S925@1236|Gammaproteobacteria,1X7B2@135614|Xanthomonadales	135614|Xanthomonadales	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HKD2_k127_2144466_1	1163407.UU7_01137	1.734e-143	472.0	COG0399@1|root,COG0399@2|Bacteria,1QTGA@1224|Proteobacteria,1S1EX@1236|Gammaproteobacteria,1X5GY@135614|Xanthomonadales	135614|Xanthomonadales	M	Belongs to the DegT DnrJ EryC1 family	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
HKD2_k127_2144466_4	1163407.UU7_01127	1.321e-129	425.0	COG3146@1|root,COG3146@2|Bacteria,1R5A3@1224|Proteobacteria,1RZ9Q@1236|Gammaproteobacteria,1X3I0@135614|Xanthomonadales	135614|Xanthomonadales	S	Peptidogalycan biosysnthesis/recognition	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_6,FemAB_like
HKD2_k127_2144466_2	1234364.AMSF01000071_gene1756	6.094e-138	442.0	COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,1RMDE@1236|Gammaproteobacteria,1X3GS@135614|Xanthomonadales	135614|Xanthomonadales	IQ	Belongs to the beta-ketoacyl-ACP synthases family	-	-	-	ko:K14660	-	-	-	-	ko00000,ko01000	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
HKD2_k127_2148475_2	700598.Niako_0294	5.365e-11	65.0	COG0217@1|root,COG0217@2|Bacteria,4NE8Y@976|Bacteroidetes,1IQCX@117747|Sphingobacteriia	976|Bacteroidetes	K	transcriptional regulatory protein	yebC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	-	-	-	-	-	-	-	-	-	Transcrip_reg
HKD2_k127_2148475_1	118161.KB235922_gene4986	8.514e-59	213.0	COG0500@1|root,COG2226@2|Bacteria,1G0GS@1117|Cyanobacteria,3VIJE@52604|Pleurocapsales	1117|Cyanobacteria	Q	Hypothetical methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
HKD2_k127_2148475_0	1265313.HRUBRA_02126	3.919e-137	453.0	COG4774@1|root,COG4774@2|Bacteria,1RBVQ@1224|Proteobacteria,1SMVM@1236|Gammaproteobacteria,1J8EM@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	TonB-dependent Receptor Plug Domain	-	-	-	-	-	-	-	-	-	-	-	-	Plug
HKD2_k127_223017_11	521045.Kole_0059	2.097e-05	54.0	29PB5@1|root,32E1H@2|Bacteria,2GE4P@200918|Thermotogae	200918|Thermotogae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_223017_6	84531.JMTZ01000002_gene778	2.107e-116	387.0	COG1075@1|root,COG1075@2|Bacteria,1R88U@1224|Proteobacteria,1S0MF@1236|Gammaproteobacteria,1X6S0@135614|Xanthomonadales	135614|Xanthomonadales	S	PGAP1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	PGAP1
HKD2_k127_223017_9	1123519.PSJM300_04895	6.403e-21	96.0	COG2944@1|root,COG2944@2|Bacteria,1MZGM@1224|Proteobacteria,1TBCN@1236|Gammaproteobacteria,1Z37I@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	K	Transcriptional regulator	-	-	-	ko:K07726	-	-	-	-	ko00000,ko03000	-	-	-	HTH_3
HKD2_k127_223017_10	391595.RLO149_c035340	4.68e-06	54.0	COG3809@1|root,COG3809@2|Bacteria,1N6ZY@1224|Proteobacteria,2UFVY@28211|Alphaproteobacteria,2P3UP@2433|Roseobacter	28211|Alphaproteobacteria	S	Transcription factor zinc-finger	-	-	-	ko:K09981	-	-	-	-	ko00000	-	-	-	zf-TFIIB
HKD2_k127_223017_5	1265313.HRUBRA_00325	4.186e-118	399.0	COG0028@1|root,COG0028@2|Bacteria,1MX6Q@1224|Proteobacteria,1RRJR@1236|Gammaproteobacteria	1236|Gammaproteobacteria	EH	Belongs to the TPP enzyme family	mdlC	-	4.1.1.7	ko:K01576	ko00627,ko01120,map00627,map01120	-	R01764,R02672	RC00595	ko00000,ko00001,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
HKD2_k127_223017_7	247634.GPB2148_1976	8.91e-84	307.0	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1S5TW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_2,TPR_8,Trans_reg_C
HKD2_k127_223017_1	1300345.LF41_1243	1.193e-232	735.0	COG4252@1|root,COG4252@2|Bacteria,1R9GK@1224|Proteobacteria	1224|Proteobacteria	T	CHASE2 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CHASE2
HKD2_k127_223017_3	1300345.LF41_1244	4.816e-124	411.0	COG3103@1|root,COG4783@1|root,COG3103@2|Bacteria,COG4783@2|Bacteria,1MVFV@1224|Proteobacteria,1T5AG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Peptidase family M48	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
HKD2_k127_223017_8	113395.AXAI01000003_gene5841	1.156e-56	201.0	COG3791@1|root,COG3791@2|Bacteria,1RAJQ@1224|Proteobacteria,2U5ME@28211|Alphaproteobacteria,3JY8E@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Glutathione-dependent formaldehyde-activating enzyme	-	-	-	-	-	-	-	-	-	-	-	-	GFA
HKD2_k127_223017_2	314278.NB231_10403	1.298e-164	529.0	COG2719@1|root,COG2719@2|Bacteria,1MW6U@1224|Proteobacteria,1RPU2@1236|Gammaproteobacteria,1WWU8@135613|Chromatiales	135613|Chromatiales	S	SpoVR family	-	-	-	ko:K06415	-	-	-	-	ko00000	-	-	-	SpoVR
HKD2_k127_223017_4	314278.NB231_10398	4.032e-118	392.0	COG2718@1|root,COG2718@2|Bacteria,1MWQM@1224|Proteobacteria,1RQWC@1236|Gammaproteobacteria,1WWH8@135613|Chromatiales	135613|Chromatiales	S	Belongs to the UPF0229 family	-	-	-	ko:K09786	-	-	-	-	ko00000	-	-	-	DUF444
HKD2_k127_223017_0	314278.NB231_10393	7.021e-300	934.0	COG2766@1|root,COG2766@2|Bacteria,1MVW7@1224|Proteobacteria,1RNFJ@1236|Gammaproteobacteria,1WWXB@135613|Chromatiales	135613|Chromatiales	T	PFAM PrkA AAA	-	-	-	ko:K07180	-	-	-	-	ko00000	-	-	-	AAA_PrkA,PrkA
HKD2_k127_2315464_2	1071679.BG57_18970	2.977e-40	152.0	COG2985@1|root,COG2985@2|Bacteria,1MUVM@1224|Proteobacteria,2VMWJ@28216|Betaproteobacteria,1KHE3@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Predicted Permease Membrane Region	-	-	-	ko:K07085	-	-	-	-	ko00000	2.A.81	-	-	Asp-Al_Ex,TrkA_C
HKD2_k127_2315464_0	266264.Rmet_1985	1.984e-145	479.0	COG2985@1|root,COG2985@2|Bacteria,1MUVM@1224|Proteobacteria,2VMWJ@28216|Betaproteobacteria,1KHE3@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Predicted Permease Membrane Region	-	-	-	ko:K07085	-	-	-	-	ko00000	2.A.81	-	-	Asp-Al_Ex,TrkA_C
HKD2_k127_2315464_1	1458357.BG58_09870	2.412e-104	350.0	COG1538@1|root,COG1538@2|Bacteria,1REC6@1224|Proteobacteria,2VZ9S@28216|Betaproteobacteria,1KBKV@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
HKD2_k127_2426164_27	314278.NB231_11894	7.173e-100	329.0	COG2255@1|root,COG2255@2|Bacteria,1MU38@1224|Proteobacteria,1RNWY@1236|Gammaproteobacteria,1WWB3@135613|Chromatiales	135613|Chromatiales	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing	ruvB	-	3.6.4.12	ko:K03551	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvB_C,RuvB_N
HKD2_k127_2426164_34	765912.Thimo_0571	4.856e-77	263.0	COG0811@1|root,COG0811@2|Bacteria,1NCWW@1224|Proteobacteria,1RMD4@1236|Gammaproteobacteria,1WWA0@135613|Chromatiales	135613|Chromatiales	U	PFAM MotA TolQ ExbB proton channel	-	-	-	ko:K03562	ko01120,map01120	-	-	-	ko00000,ko02000	1.A.30.2.2	-	-	MotA_ExbB
HKD2_k127_2426164_50	247639.MGP2080_00280	2.34e-39	151.0	COG0848@1|root,COG0848@2|Bacteria,1MZ6M@1224|Proteobacteria,1S8RS@1236|Gammaproteobacteria,1J6H1@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	U	Biopolymer transport protein	tolR	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0015833,GO:0015893,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0032153,GO:0042221,GO:0042493,GO:0042886,GO:0042891,GO:0043213,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944	-	ko:K03560	-	-	-	-	ko00000,ko02000	1.A.30.2.2	-	-	ExbD
HKD2_k127_2426164_69	243233.MCA1228	2.126e-13	80.0	COG0810@1|root,COG0810@2|Bacteria,1QXPZ@1224|Proteobacteria,1T3FQ@1236|Gammaproteobacteria,1XH0Z@135618|Methylococcales	135618|Methylococcales	M	TolA C-terminal	-	-	-	ko:K03646	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	TonB_2
HKD2_k127_2426164_15	519989.ECTPHS_02194	3.799e-136	450.0	COG0823@1|root,COG0823@2|Bacteria,1MV09@1224|Proteobacteria,1RMCY@1236|Gammaproteobacteria,1WVZJ@135613|Chromatiales	135613|Chromatiales	U	Involved in the TonB-independent uptake of proteins	tolB	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40,TolB_N
HKD2_k127_2426164_51	1123257.AUFV01000002_gene2636	3.173e-39	153.0	COG2885@1|root,COG2885@2|Bacteria,1MZTV@1224|Proteobacteria,1S8RG@1236|Gammaproteobacteria,1X5FX@135614|Xanthomonadales	135614|Xanthomonadales	M	Belongs to the ompA family	pal	-	-	ko:K03640	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	OmpA
HKD2_k127_2426164_53	1335757.SPICUR_02180	7.973e-36	146.0	COG1729@1|root,COG1729@2|Bacteria,1MUSV@1224|Proteobacteria,1RQWA@1236|Gammaproteobacteria,1WW2G@135613|Chromatiales	135613|Chromatiales	D	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division	cpoB	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_6,TolA_bind_tri,YfiO
HKD2_k127_2426164_31	1211114.ALIP01000130_gene2191	1.423e-93	319.0	COG0602@1|root,COG0602@2|Bacteria,1MUJ2@1224|Proteobacteria,1RNQZ@1236|Gammaproteobacteria,1X4FR@135614|Xanthomonadales	135614|Xanthomonadales	H	Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds	queE	-	4.3.99.3	ko:K10026	ko00790,ko01100,map00790,map01100	-	R10002	RC02989	ko00000,ko00001,ko01000,ko03016	-	-	-	Fer4_14,Radical_SAM
HKD2_k127_2426164_29	292415.Tbd_2202	4.029e-96	323.0	COG0603@1|root,COG0603@2|Bacteria,1MU5V@1224|Proteobacteria,2VHY3@28216|Betaproteobacteria,1KS0G@119069|Hydrogenophilales	119069|Hydrogenophilales	F	Queuosine biosynthesis protein QueC	-	-	6.3.4.20	ko:K06920	ko00790,ko01100,map00790,map01100	-	R09978	RC00959	ko00000,ko00001,ko01000,ko03016	-	-	-	QueC
HKD2_k127_2426164_75	1127673.GLIP_2679	0.0006314	45.0	2DT0U@1|root,33I6V@2|Bacteria,1NMHR@1224|Proteobacteria,1SGK7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2426164_70	1044.EH31_07565	8.126e-12	69.0	COG2227@1|root,COG2227@2|Bacteria,1QUP9@1224|Proteobacteria,2TW2X@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23
HKD2_k127_2426164_13	91464.S7335_198	4.668e-147	479.0	COG0518@1|root,COG0518@2|Bacteria,1G17E@1117|Cyanobacteria,1GYTN@1129|Synechococcus	1117|Cyanobacteria	F	GMP synthase (glutamine-hydrolyzing) activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2426164_18	1479237.JMLY01000001_gene2823	1.375e-119	399.0	COG1448@1|root,COG1448@2|Bacteria,1MUT0@1224|Proteobacteria,1RN02@1236|Gammaproteobacteria,4647G@72275|Alteromonadaceae	1236|Gammaproteobacteria	E	COG1448 Aspartate tyrosine aromatic aminotransferase	phhC	-	2.6.1.1,2.6.1.57	ko:K00813,ko:K00832	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	M00024,M00025,M00034,M00040	R00355,R00694,R00734,R00896,R01731,R02433,R02619,R05052,R07396,R10845	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
HKD2_k127_2426164_22	1248760.ANFZ01000012_gene39	4.996e-105	384.0	COG2271@1|root,COG2271@2|Bacteria,1QVY6@1224|Proteobacteria,2TWTV@28211|Alphaproteobacteria,2KEFC@204457|Sphingomonadales	204457|Sphingomonadales	G	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD2_k127_2426164_8	1123256.KB907947_gene2649	1.46e-189	600.0	COG0477@1|root,COG2814@2|Bacteria,1MWKH@1224|Proteobacteria,1T5I8@1236|Gammaproteobacteria,1XC6T@135614|Xanthomonadales	135614|Xanthomonadales	EGP	Sugar (and other) transporter	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD2_k127_2426164_52	1123279.ATUS01000001_gene1962	1.356e-38	153.0	COG0779@1|root,COG0779@2|Bacteria,1RDP2@1224|Proteobacteria,1S3Y7@1236|Gammaproteobacteria,1J676@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	Required for maturation of 30S ribosomal subunits	rimP	GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576	-	ko:K09748	-	-	-	-	ko00000,ko03009	-	-	-	DUF150,DUF150_C
HKD2_k127_2426164_6	396588.Tgr7_1002	2.048e-222	699.0	COG0195@1|root,COG0195@2|Bacteria,1MWT7@1224|Proteobacteria,1RNQS@1236|Gammaproteobacteria,1WVXP@135613|Chromatiales	135613|Chromatiales	K	Participates in both transcription termination and antitermination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	HHH_5,KH_5,NusA_N,S1
HKD2_k127_2426164_2	396588.Tgr7_1003	5.244e-291	916.0	COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,1RM9X@1236|Gammaproteobacteria,1WVXH@135613|Chromatiales	135613|Chromatiales	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,GTP_EFTU_D2,IF-2,IF2_N,IF2_assoc
HKD2_k127_2426164_62	287.DR97_2086	2.836e-24	106.0	COG0858@1|root,COG0858@2|Bacteria,1MZPE@1224|Proteobacteria,1S9AF@1236|Gammaproteobacteria,1YG3C@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	J	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA	rbfA	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009266,GO:0009409,GO:0009628,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0030490,GO:0033554,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042274,GO:0043021,GO:0043024,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071840,GO:0090304,GO:1901360	-	ko:K02834	-	-	-	-	ko00000,ko03009	-	-	-	RBFA
HKD2_k127_2426164_37	754476.Q7A_1299	7.612e-72	257.0	COG0130@1|root,COG0130@2|Bacteria,1MV0N@1224|Proteobacteria,1RMKP@1236|Gammaproteobacteria,460E5@72273|Thiotrichales	72273|Thiotrichales	J	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs	truB	-	5.4.99.25	ko:K03177	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruB-C_2,TruB_C_2,TruB_N
HKD2_k127_2426164_56	1033802.SSPSH_002381	2.564e-33	131.0	COG0184@1|root,COG0184@2|Bacteria,1MZ2W@1224|Proteobacteria,1S8U6@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome	rpsO	GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006378,GO:0006396,GO:0006397,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016070,GO:0016071,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0031123,GO:0031124,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043631,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02956	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S15
HKD2_k127_2426164_1	519989.ECTPHS_07267	3.131e-311	968.0	COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,1RNBF@1236|Gammaproteobacteria,1WW27@135613|Chromatiales	135613|Chromatiales	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	-	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
HKD2_k127_2426164_54	187272.Mlg_2487	5.959e-34	140.0	COG5394@1|root,COG5394@2|Bacteria,1RHRC@1224|Proteobacteria,1S2XX@1236|Gammaproteobacteria,1WY2K@135613|Chromatiales	135613|Chromatiales	S	TIGRFAM Polyhydroxyalkanoate synthesis repressor PhaR	-	-	-	-	-	-	-	-	-	-	-	-	PHB_acc,PHB_acc_N
HKD2_k127_2426164_32	1304883.KI912532_gene1181	1.526e-84	292.0	COG0008@1|root,COG0008@2|Bacteria,1MUN7@1224|Proteobacteria,2VHYK@28216|Betaproteobacteria,2KV7X@206389|Rhodocyclales	206389|Rhodocyclales	J	Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon	gluQ	-	-	ko:K01894	-	-	-	-	ko00000,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1c
HKD2_k127_2426164_45	686340.Metal_1078	8.417e-49	183.0	COG1734@1|root,COG1734@2|Bacteria,1RD08@1224|Proteobacteria,1S47H@1236|Gammaproteobacteria,1XF2E@135618|Methylococcales	135618|Methylococcales	T	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression	dksA	-	-	ko:K06204	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000,ko03009,ko03021	-	-	-	zf-dskA_traR
HKD2_k127_2426164_0	396588.Tgr7_2026	0.0	1088.0	COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,1RNA6@1236|Gammaproteobacteria,1WW7V@135613|Chromatiales	135613|Chromatiales	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
HKD2_k127_2426164_65	472759.Nhal_1448	3.758e-22	108.0	COG3115@1|root,COG3115@2|Bacteria,1MVHR@1224|Proteobacteria,1RMDB@1236|Gammaproteobacteria,1WZA1@135613|Chromatiales	135613|Chromatiales	D	Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins	zipA	-	-	ko:K03528	-	-	-	-	ko00000,ko03036	-	-	-	ZipA_C
HKD2_k127_2426164_3	388051.AUFE01000007_gene1443	5.928e-248	783.0	COG0272@1|root,COG0272@2|Bacteria,1MV3R@1224|Proteobacteria,2VIDE@28216|Betaproteobacteria,1K0GW@119060|Burkholderiaceae	28216|Betaproteobacteria	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	-	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5
HKD2_k127_2426164_14	342610.Patl_2767	5.002e-143	470.0	COG0277@1|root,COG0277@2|Bacteria,1N22A@1224|Proteobacteria,1S1MW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	FAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_4
HKD2_k127_2426164_59	983545.Glaag_1574	6.966e-32	128.0	2EBHU@1|root,335I9@2|Bacteria,1N2MU@1224|Proteobacteria,1S9MV@1236|Gammaproteobacteria,46BQV@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	REDY-like protein HapK	-	-	-	-	-	-	-	-	-	-	-	-	HapK
HKD2_k127_2426164_19	1178482.BJB45_00960	1.988e-119	391.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,1RNJ1@1236|Gammaproteobacteria,1XJ29@135619|Oceanospirillales	135619|Oceanospirillales	P	transporter, permease	oppB	-	-	ko:K02033,ko:K15581	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	BPD_transp_1
HKD2_k127_2426164_23	553385.JEMF01000031_gene2681	8.572e-104	345.0	COG1173@1|root,COG1173@2|Bacteria,1MU26@1224|Proteobacteria,1RND6@1236|Gammaproteobacteria,1XH9S@135619|Oceanospirillales	135619|Oceanospirillales	EP	N-terminal TM domain of oligopeptide transport permease C	-	-	-	ko:K02034,ko:K15582	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	BPD_transp_1,OppC_N
HKD2_k127_2426164_30	1472716.KBK24_0109250	5.628e-94	323.0	COG0444@1|root,COG0444@2|Bacteria,1R4KB@1224|Proteobacteria,2W0NK@28216|Betaproteobacteria,1K0G7@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Belongs to the ABC transporter superfamily	oppD	-	-	ko:K02031,ko:K15583	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
HKD2_k127_2426164_38	1121028.ARQE01000010_gene1060	1.065e-71	253.0	COG4608@1|root,COG4608@2|Bacteria,1NU4K@1224|Proteobacteria,2TQTV@28211|Alphaproteobacteria,2PKI9@255475|Aurantimonadaceae	28211|Alphaproteobacteria	E	Oligopeptide/dipeptide transporter, C-terminal region	oppF	GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0008144,GO:0016020,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044464,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
HKD2_k127_2426164_49	1123269.NX02_13840	3.749e-42	166.0	COG0346@1|root,COG0346@2|Bacteria,1RDMC@1224|Proteobacteria,2U54J@28211|Alphaproteobacteria,2K37X@204457|Sphingomonadales	204457|Sphingomonadales	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2426164_5	566466.NOR53_1071	9.982e-227	720.0	COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,1MVE0@1224|Proteobacteria,1RNM8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	COG1902 NADH flavin oxidoreductases, Old Yellow Enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_FMN,Pyr_redox_2
HKD2_k127_2426164_33	909663.KI867150_gene2054	2.627e-81	276.0	COG2836@1|root,COG2836@2|Bacteria,1QVGG@1224|Proteobacteria,432GS@68525|delta/epsilon subdivisions,2WXZW@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Cytochrome C biogenesis protein transmembrane region	-	-	-	-	-	-	-	-	-	-	-	-	DsbD_2
HKD2_k127_2426164_21	1397666.RS24_00311	4.064e-105	352.0	COG0803@1|root,COG0803@2|Bacteria,1R91T@1224|Proteobacteria,2TRDQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Belongs to the bacterial solute-binding protein 9 family	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_7
HKD2_k127_2426164_11	1042377.AFPJ01000009_gene235	1.242e-163	524.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,1RNB5@1236|Gammaproteobacteria,465FA@72275|Alteromonadaceae	1236|Gammaproteobacteria	C	acyl-CoA transferases carnitine dehydratase	coaT	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
HKD2_k127_2426164_12	1385517.N800_02885	4.996e-148	480.0	COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,1RN5B@1236|Gammaproteobacteria,1X32P@135614|Xanthomonadales	135614|Xanthomonadales	E	aminotransferase	-	-	2.6.1.2,2.6.1.66	ko:K14260	ko00220,ko00250,ko00290,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00290,map01100,map01110,map01130,map01210,map01230	-	R00258,R01215	RC00006,RC00008,RC00036	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
HKD2_k127_2426164_17	105559.Nwat_2049	3.411e-125	433.0	COG3857@1|root,COG3857@2|Bacteria,1QUQD@1224|Proteobacteria,1T20Z@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	PD-(D/E)XK nuclease superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_1
HKD2_k127_2426164_4	1123261.AXDW01000006_gene2409	8.613e-240	782.0	COG1074@1|root,COG1074@2|Bacteria,1MUTF@1224|Proteobacteria,1RPC6@1236|Gammaproteobacteria,1X3M3@135614|Xanthomonadales	135614|Xanthomonadales	L	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA	recB	-	3.1.11.5	ko:K03582	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
HKD2_k127_2426164_74	1036674.A28LD_1728	2.58e-05	55.0	2CBG9@1|root,30STC@2|Bacteria,1QFRF@1224|Proteobacteria,1TCNU@1236|Gammaproteobacteria,2QGBM@267893|Idiomarinaceae	1236|Gammaproteobacteria	S	Type II secretion system (T2SS), protein N	-	-	-	ko:K02463	ko05111,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSN
HKD2_k127_2426164_64	396588.Tgr7_0237	1.254e-22	111.0	COG3149@1|root,COG3149@2|Bacteria,1N8VZ@1224|Proteobacteria,1SCSU@1236|Gammaproteobacteria,1WZQA@135613|Chromatiales	135613|Chromatiales	U	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins	-	-	-	ko:K02462	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSM
HKD2_k127_2426164_55	349124.Hhal_2388	2.224e-33	145.0	COG3297@1|root,COG3297@2|Bacteria,1NVVW@1224|Proteobacteria,1S01F@1236|Gammaproteobacteria,1X1FM@135613|Chromatiales	135613|Chromatiales	U	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins	-	-	-	ko:K02461	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	GspL_C,T2SSL
HKD2_k127_2426164_44	1499686.BN1079_02669	7.316e-50	198.0	COG3156@1|root,COG3156@2|Bacteria,1RBNV@1224|Proteobacteria,1S5US@1236|Gammaproteobacteria	1236|Gammaproteobacteria	U	COG3156 Type II secretory pathway, component PulK	xcpX	-	-	ko:K02460	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSK
HKD2_k127_2426164_57	1304275.C41B8_02832	5.715e-33	141.0	COG4795@1|root,COG4795@2|Bacteria,1RJAE@1224|Proteobacteria,1S5ZZ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	U	General secretion pathway protein J	gspJ	GO:0002790,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015628,GO:0015833,GO:0032940,GO:0033036,GO:0042886,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0098776	-	ko:K02459	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl,T2SSJ
HKD2_k127_2426164_66	1123261.AXDW01000004_gene2861	2.088e-18	94.0	COG2165@1|root,COG2165@2|Bacteria,1N737@1224|Proteobacteria,1SC8X@1236|Gammaproteobacteria,1X8HU@135614|Xanthomonadales	135614|Xanthomonadales	NU	Type II secretion system (T2SS), protein I	-	-	-	-	-	-	-	-	-	-	-	-	N_methyl,T2SSI
HKD2_k127_2426164_71	1269813.ATUL01000010_gene498	3.629e-11	72.0	COG2165@1|root,COG2165@2|Bacteria,1N7HZ@1224|Proteobacteria,1SCWD@1236|Gammaproteobacteria,1X1VZ@135613|Chromatiales	135613|Chromatiales	NU	general secretion pathway protein h	-	-	-	ko:K02457	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	GspH,N_methyl
HKD2_k127_2426164_42	396588.Tgr7_0231	3.091e-55	198.0	COG2165@1|root,COG2165@2|Bacteria,1RDX2@1224|Proteobacteria,1S3VS@1236|Gammaproteobacteria,1WY8U@135613|Chromatiales	135613|Chromatiales	U	general secretion pathway protein G	-	-	-	ko:K02456	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl,T2SSG
HKD2_k127_2426164_61	1049564.TevJSym_as00760	2.426e-29	125.0	COG0705@1|root,COG0705@2|Bacteria,1N8NS@1224|Proteobacteria,1SD4M@1236|Gammaproteobacteria,1J76C@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Rhomboid family	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
HKD2_k127_2426164_20	396588.Tgr7_1836	1.592e-113	375.0	COG0331@1|root,COG0331@2|Bacteria,1MV6N@1224|Proteobacteria,1RNH3@1236|Gammaproteobacteria,1WWNS@135613|Chromatiales	135613|Chromatiales	I	TIGRFAM malonyl CoA-acyl carrier protein transacylase	-	-	2.3.1.39	ko:K00645	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	M00082	R01626,R11671	RC00004,RC00039,RC02727	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyl_transf_1
HKD2_k127_2426164_24	1442599.JAAN01000031_gene1439	2.878e-102	339.0	COG1028@1|root,COG1028@2|Bacteria,1MU6X@1224|Proteobacteria,1RMBB@1236|Gammaproteobacteria,1X475@135614|Xanthomonadales	135614|Xanthomonadales	IQ	Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis	fabG	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HKD2_k127_2426164_58	519989.ECTPHS_03217	1.891e-32	127.0	COG0236@1|root,COG0236@2|Bacteria,1MZ4P@1224|Proteobacteria,1S8X4@1236|Gammaproteobacteria,1WYUG@135613|Chromatiales	135613|Chromatiales	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	acpP	-	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
HKD2_k127_2426164_10	1123401.JHYQ01000031_gene3404	9.857e-174	556.0	COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,1RMDE@1236|Gammaproteobacteria,45ZQ6@72273|Thiotrichales	72273|Thiotrichales	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	fabF	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
HKD2_k127_2426164_16	935567.JAES01000030_gene2863	1.961e-131	437.0	COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,1RMSE@1236|Gammaproteobacteria,1X55Q@135614|Xanthomonadales	135614|Xanthomonadales	EH	component I	pabB	-	4.1.3.27	ko:K01657	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
HKD2_k127_2426164_43	399739.Pmen_1631	2.354e-53	202.0	COG0115@1|root,COG0115@2|Bacteria,1MZAK@1224|Proteobacteria,1RPPG@1236|Gammaproteobacteria,1YEWP@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	EH	Amino-transferase class IV	pabC	GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008696,GO:0009987,GO:0016829,GO:0016830,GO:0016833,GO:0019752,GO:0019842,GO:0030170,GO:0034641,GO:0036094,GO:0042558,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0044237,GO:0044281,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0070279,GO:0071704,GO:0097159,GO:1901360,GO:1901363,GO:1901564	4.1.3.38	ko:K02619	ko00790,map00790	-	R05553	RC01843,RC02148	ko00000,ko00001,ko01000	-	-	iAPECO1_1312.APECO1_177,iE2348C_1286.E2348C_1188,iECED1_1282.ECED1_1239,iECNA114_1301.ECNA114_1153,iECOK1_1307.ECOK1_1203,iECS88_1305.ECS88_1110,iECSF_1327.ECSF_0995,iECUMN_1333.ECUMN_1273,iJN746.PP_1917,iPC815.YPO1603,iUMN146_1321.UM146_11845,iUTI89_1310.UTI89_C1222,ic_1306.c1366	Aminotran_4
HKD2_k127_2426164_28	187272.Mlg_1417	1.37e-98	334.0	COG1559@1|root,COG1559@2|Bacteria,1MUQF@1224|Proteobacteria,1RMWD@1236|Gammaproteobacteria,1WWK3@135613|Chromatiales	135613|Chromatiales	S	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation	mltG	-	-	ko:K07082	-	-	-	-	ko00000	-	-	-	YceG
HKD2_k127_2426164_39	713586.KB900536_gene666	7.21e-67	234.0	COG0125@1|root,COG0125@2|Bacteria,1MV9C@1224|Proteobacteria,1S26C@1236|Gammaproteobacteria,1WX8U@135613|Chromatiales	135613|Chromatiales	F	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis	tmk	-	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylate_kin
HKD2_k127_2426164_47	1397528.Q671_05945	4.34e-47	184.0	COG0470@1|root,COG0470@2|Bacteria,1MY1W@1224|Proteobacteria,1RNYA@1236|Gammaproteobacteria,1XIFW@135619|Oceanospirillales	135619|Oceanospirillales	L	DNA polymerase III subunit delta	holB	-	2.7.7.7	ko:K02341	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNApol3-delta_C
HKD2_k127_2426164_46	1123261.AXDW01000004_gene2877	3.423e-47	174.0	COG3215@1|root,COG3215@2|Bacteria,1RGWZ@1224|Proteobacteria,1S4YE@1236|Gammaproteobacteria,1X6W7@135614|Xanthomonadales	135614|Xanthomonadales	NU	Pilus assembly protein PilZ	pilZ	-	-	ko:K02676	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilZ
HKD2_k127_2426164_25	391615.ABSJ01000026_gene110	2.551e-101	341.0	COG0607@1|root,COG0664@1|root,COG0607@2|Bacteria,COG0664@2|Bacteria,1R9Q1@1224|Proteobacteria,1RSKD@1236|Gammaproteobacteria,1J6A4@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	PT	COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese,cNMP_binding
HKD2_k127_2426164_7	1283300.ATXB01000002_gene3073	1.752e-202	651.0	COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,1RMZ8@1236|Gammaproteobacteria,1XEFK@135618|Methylococcales	135618|Methylococcales	I	Enoyl-CoA hydratase/isomerase	-	-	-	-	-	-	-	-	-	-	-	-	3HCDH,3HCDH_N,ECH_1
HKD2_k127_2426164_35	1121405.dsmv_2076	6.281e-77	265.0	COG3568@1|root,COG3568@2|Bacteria,1RBWV@1224|Proteobacteria,42QPA@68525|delta/epsilon subdivisions,2WMPU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	PFAM Endonuclease Exonuclease phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
HKD2_k127_2426164_67	596323.HMPREF0554_0261	6.381e-17	86.0	arCOG06471@1|root,32BPX@2|Bacteria	2|Bacteria	S	MTH538 TIR-like domain (DUF1863)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1863
HKD2_k127_2426164_72	292415.Tbd_2026	3.634e-11	68.0	COG2863@1|root,COG2863@2|Bacteria,1N7W9@1224|Proteobacteria,2VUTK@28216|Betaproteobacteria	28216|Betaproteobacteria	C	cytochrome	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,Cytochrome_CBB3
HKD2_k127_2426164_63	1120999.JONM01000003_gene2633	3.872e-23	105.0	2E4IS@1|root,32ZDU@2|Bacteria,1N7N3@1224|Proteobacteria,2VVSI@28216|Betaproteobacteria	28216|Betaproteobacteria	S	PFAM PsiF repeat protein	psiF	-	-	-	-	-	-	-	-	-	-	-	PsiF_repeat
HKD2_k127_2426164_68	365044.Pnap_0159	5.093e-14	75.0	2E75R@1|root,331PX@2|Bacteria,1NAGT@1224|Proteobacteria,2W4DV@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2426164_48	279238.Saro_3537	4.816e-45	169.0	COG0346@1|root,COG0346@2|Bacteria,1MWHG@1224|Proteobacteria,2UF29@28211|Alphaproteobacteria,2K7AS@204457|Sphingomonadales	204457|Sphingomonadales	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase_4
HKD2_k127_2426164_36	1123073.KB899241_gene2873	3.824e-74	256.0	arCOG07533@1|root,2ZF5I@2|Bacteria,1RB8D@1224|Proteobacteria,1SBRH@1236|Gammaproteobacteria,1X79G@135614|Xanthomonadales	135614|Xanthomonadales	S	Domain of unknown function (DUF4386)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4386
HKD2_k127_2426164_41	748247.AZKH_p0638	4.458e-57	207.0	COG3134@1|root,COG3134@2|Bacteria,1MVWD@1224|Proteobacteria,2WA93@28216|Betaproteobacteria,2KZI5@206389|Rhodocyclales	206389|Rhodocyclales	S	Glycine zipper 2TM domain	-	-	-	-	-	-	-	-	-	-	-	-	Rick_17kDa_Anti
HKD2_k127_2426164_40	1121921.KB898706_gene2488	1.598e-59	217.0	2910Q@1|root,2ZNNC@2|Bacteria,1PCP3@1224|Proteobacteria,1S0BX@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2426164_60	469371.Tbis_1317	4.534e-30	124.0	COG4828@1|root,COG4828@2|Bacteria,2IQJ3@201174|Actinobacteria,4E5QJ@85010|Pseudonocardiales	201174|Actinobacteria	S	Protein of unknown function (DUF1622)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1622
HKD2_k127_2426164_9	1215092.PA6_006_01230	9.179e-185	597.0	COG0659@1|root,COG0659@2|Bacteria,1MWDF@1224|Proteobacteria,1SYC8@1236|Gammaproteobacteria,1YDC3@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	U	Sulfate permease family	-	-	-	-	-	-	-	-	-	-	-	-	STAS,Sulfate_transp
HKD2_k127_2427637_17	1121013.P873_05930	7.378e-82	274.0	COG0302@1|root,COG0302@2|Bacteria,1MY3N@1224|Proteobacteria,1RMQM@1236|Gammaproteobacteria,1X3YF@135614|Xanthomonadales	135614|Xanthomonadales	F	GTP cyclohydrolase	folE	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003933,GO:0003934,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006066,GO:0006725,GO:0006729,GO:0006732,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009108,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019238,GO:0019438,GO:0019751,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034311,GO:0034312,GO:0034641,GO:0035639,GO:0036094,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	3.5.4.16	ko:K01495	ko00790,ko01100,map00790,map01100	M00126,M00841,M00842,M00843	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	-	GTP_cyclohydroI
HKD2_k127_2427637_4	1123073.KB899241_gene2287	4.464e-215	674.0	COG0404@1|root,COG0404@2|Bacteria,1MV96@1224|Proteobacteria,1RN2A@1236|Gammaproteobacteria,1X7MH@135614|Xanthomonadales	135614|Xanthomonadales	E	Glycine cleavage T-protein C-terminal barrel domain	-	-	-	-	-	-	-	-	-	-	-	-	GCV_T,GCV_T_C
HKD2_k127_2427637_1	1300345.LF41_2243	8.201e-302	933.0	COG1233@1|root,COG1233@2|Bacteria,1MV2R@1224|Proteobacteria,1RSGI@1236|Gammaproteobacteria,1X5MS@135614|Xanthomonadales	135614|Xanthomonadales	Q	Oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
HKD2_k127_2427637_6	1300345.LF41_2242	1.597e-198	631.0	COG1233@1|root,COG1233@2|Bacteria,1MV2R@1224|Proteobacteria,1T7S9@1236|Gammaproteobacteria,1X9NA@135614|Xanthomonadales	135614|Xanthomonadales	Q	Thi4 family	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
HKD2_k127_2427637_7	1300345.LF41_2246	6.401e-169	557.0	COG0531@1|root,COG0531@2|Bacteria,1MUA2@1224|Proteobacteria,1RRKS@1236|Gammaproteobacteria,1X4PJ@135614|Xanthomonadales	135614|Xanthomonadales	E	Amino acid permease	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
HKD2_k127_2427637_8	1163409.UUA_08361	1.621e-165	545.0	COG4638@1|root,COG4638@2|Bacteria,1MWXW@1224|Proteobacteria,1S9NJ@1236|Gammaproteobacteria,1X5C8@135614|Xanthomonadales	135614|Xanthomonadales	P	COG4638 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit	-	-	1.14.12.1,1.14.15.7	ko:K00499,ko:K16319	ko00260,ko00627,ko01120,map00260,map00627,map01120	M00637	R00823,R00825,R07409	RC00087,RC00192	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	Rieske,Ring_hydroxyl_A
HKD2_k127_2427637_0	1163409.UUA_08346	0.0	1178.0	COG0823@1|root,COG0823@2|Bacteria,1MWYK@1224|Proteobacteria,1RXYW@1236|Gammaproteobacteria,1XD03@135614|Xanthomonadales	135614|Xanthomonadales	U	WD40-like Beta Propeller Repeat	-	-	-	-	-	-	-	-	-	-	-	-	PD40
HKD2_k127_2427637_3	1384054.N790_05515	8.968e-237	737.0	COG0160@1|root,COG0160@2|Bacteria,1MWY6@1224|Proteobacteria,1RMP0@1236|Gammaproteobacteria,1X4KU@135614|Xanthomonadales	135614|Xanthomonadales	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.19	ko:K00823	ko00250,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00410,map00640,map00650,map01100,map01120	M00027	R00908,R01648	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
HKD2_k127_2427637_12	1163409.UUA_08336	1.281e-120	397.0	COG2057@1|root,COG2057@2|Bacteria,1MY3S@1224|Proteobacteria,1RP1U@1236|Gammaproteobacteria,1X4IB@135614|Xanthomonadales	135614|Xanthomonadales	I	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit	gctB	-	2.8.3.12	ko:K01040	ko00643,ko00650,ko01120,map00643,map00650,map01120	-	R04000,R05509	RC00012,RC00131,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
HKD2_k127_2427637_9	1163409.UUA_08331	1.358e-142	456.0	COG1788@1|root,COG1788@2|Bacteria,1NGS5@1224|Proteobacteria,1RRZQ@1236|Gammaproteobacteria,1X4I7@135614|Xanthomonadales	135614|Xanthomonadales	I	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit	gctA	-	2.8.3.12	ko:K01039	ko00643,ko00650,ko01120,map00643,map00650,map01120	-	R04000,R05509	RC00012,RC00131,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
HKD2_k127_2427637_2	1234364.AMSF01000036_gene247	1.439e-241	756.0	COG1012@1|root,COG1012@2|Bacteria,1QWN5@1224|Proteobacteria,1T508@1236|Gammaproteobacteria,1X5AD@135614|Xanthomonadales	135614|Xanthomonadales	C	Aldehyde dehydrogenase family	-	-	1.2.1.88	ko:K00294	ko00250,ko00330,ko01100,map00250,map00330,map01100	-	R00245,R00707,R00708,R04444,R04445,R05051	RC00080,RC00216,RC00242,RC00255	ko00000,ko00001,ko01000	-	-	-	Aldedh
HKD2_k127_2427637_5	1163409.UUA_08321	1.343e-213	671.0	COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,1RNW9@1236|Gammaproteobacteria,1X38V@135614|Xanthomonadales	135614|Xanthomonadales	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.55	ko:K15372	ko00410,ko00430,ko01100,map00410,map00430,map01100	-	R00908,R01684	RC00006,RC00062	ko00000,ko00001,ko01000	-	-	-	Aminotran_3
HKD2_k127_2427637_15	1300345.LF41_2256	1.238e-95	320.0	COG1414@1|root,COG1414@2|Bacteria,1QYTM@1224|Proteobacteria,1RUTM@1236|Gammaproteobacteria,1X68N@135614|Xanthomonadales	135614|Xanthomonadales	K	Transcriptional regulator	pcaR	-	-	ko:K02624	-	-	-	-	ko00000,ko03000	-	-	-	HTH_IclR,IclR
HKD2_k127_2427637_14	414684.RC1_3371	1.057e-96	328.0	COG0627@1|root,COG0627@2|Bacteria,1QIRQ@1224|Proteobacteria,2TUU5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Putative esterase	-	-	-	-	-	-	-	-	-	-	-	-	Esterase
HKD2_k127_2427637_10	1454004.AW11_02841	9.847e-132	431.0	COG1752@1|root,COG1752@2|Bacteria,1MUM9@1224|Proteobacteria,2VK14@28216|Betaproteobacteria	28216|Betaproteobacteria	S	PFAM Patatin	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
HKD2_k127_2427637_20	243090.RB2364	1.938e-43	171.0	COG0705@1|root,COG0705@2|Bacteria	2|Bacteria	S	proteolysis	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
HKD2_k127_2427637_19	83406.HDN1F_12450	4.494e-46	169.0	COG2146@1|root,COG2146@2|Bacteria,1NNG5@1224|Proteobacteria,1SI49@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	COG2146 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases	ndoA	-	-	ko:K05710	ko00360,ko01120,ko01220,map00360,map01120,map01220	M00545	R06782,R06783	RC00098	br01602,ko00000,ko00001,ko00002	-	-	-	Rieske,Rieske_2
HKD2_k127_2427637_18	1123020.AUIE01000045_gene5229	1.131e-81	281.0	COG0596@1|root,COG0596@2|Bacteria,1QIT9@1224|Proteobacteria,1RNP9@1236|Gammaproteobacteria,1YDBH@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	S	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
HKD2_k127_2427637_16	62928.azo1465	3.457e-91	306.0	COG0564@1|root,COG0564@2|Bacteria,1N8GW@1224|Proteobacteria,2VKYT@28216|Betaproteobacteria,2KU8I@206389|Rhodocyclales	206389|Rhodocyclales	J	COG0564 Pseudouridylate synthases, 23S RNA-specific	-	-	5.4.99.26	ko:K06175	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PseudoU_synth_2
HKD2_k127_2427637_22	314285.KT71_12245	4.892e-34	138.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088,ko:K03091	-	-	-	-	ko00000,ko03021	-	-	-	Ribosomal_S30AE,Sigma70_r2,Sigma70_r4_2
HKD2_k127_2427637_13	1117318.PRUB_11196	9.885e-97	345.0	COG1629@1|root,COG4771@2|Bacteria	2|Bacteria	P	TonB-dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	OMP_b-brl_3,Plug,TonB_dep_Rec
HKD2_k127_2427637_11	886293.Sinac_7123	7.323e-124	408.0	COG0412@1|root,COG0412@2|Bacteria,2IYMM@203682|Planctomycetes	203682|Planctomycetes	Q	COG0412 Dienelactone hydrolase	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
HKD2_k127_2427637_21	1161401.ASJA01000015_gene997	1.931e-40	156.0	COG0824@1|root,COG0824@2|Bacteria,1RI3X@1224|Proteobacteria,2UC1Z@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Thioesterase superfamily	-	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT,4HBT_2,Acyl-ACP_TE
HKD2_k127_2556865_20	258533.BN977_04686	4.378e-71	244.0	COG2110@1|root,COG2110@2|Bacteria,2IFEC@201174|Actinobacteria,235P3@1762|Mycobacteriaceae	201174|Actinobacteria	S	Appr-1'-p processing enzyme	lppD	GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Macro
HKD2_k127_2556865_16	1207063.P24_18596	3.874e-82	280.0	COG2872@1|root,COG2872@2|Bacteria,1MY0P@1224|Proteobacteria,2TRRW@28211|Alphaproteobacteria,2JPPZ@204441|Rhodospirillales	204441|Rhodospirillales	S	metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain	-	-	-	ko:K07050	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA-synt_2c,tRNA_SAD
HKD2_k127_2556865_7	1123267.JONN01000001_gene661	4.328e-135	443.0	COG0665@1|root,COG0665@2|Bacteria,1MU7M@1224|Proteobacteria,2U3N5@28211|Alphaproteobacteria,2K4RF@204457|Sphingomonadales	204457|Sphingomonadales	E	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DAO
HKD2_k127_2556865_3	414684.RC1_0278	5.277e-238	760.0	COG4773@1|root,COG4773@2|Bacteria,1QURT@1224|Proteobacteria,2TYIH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	TonB dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
HKD2_k127_2556865_1	383372.Rcas_0866	3.409e-260	811.0	COG3033@1|root,COG3033@2|Bacteria,2G7YV@200795|Chloroflexi,376SB@32061|Chloroflexia	32061|Chloroflexia	E	PFAM aromatic amino acid beta-eliminating lyase threonine aldolase	tpl	-	4.1.99.2	ko:K01668	ko00350,map00350	-	R00728	RC00355,RC00364	ko00000,ko00001,ko01000	-	-	-	Beta_elim_lyase
HKD2_k127_2556865_34	1304883.KI912532_gene2816	5.457e-13	83.0	2CM31@1|root,32SD0@2|Bacteria,1N2TZ@1224|Proteobacteria,2VUNK@28216|Betaproteobacteria,2KX3J@206389|Rhodocyclales	206389|Rhodocyclales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2556865_8	402881.Plav_0474	3.331e-122	410.0	COG1024@1|root,COG1024@2|Bacteria,1MWZC@1224|Proteobacteria,2TRYS@28211|Alphaproteobacteria,1JNH3@119043|Rhodobiaceae	28211|Alphaproteobacteria	I	PFAM Enoyl-CoA hydratase isomerase	-	-	4.2.1.17	ko:K01692	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
HKD2_k127_2556865_5	935866.JAER01000007_gene386	2.782e-204	650.0	COG1022@1|root,COG1022@2|Bacteria,2GIXQ@201174|Actinobacteria,4DNI6@85009|Propionibacteriales	201174|Actinobacteria	I	AMP-binding enzyme	fadD11	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	AMP-binding
HKD2_k127_2556865_2	987059.RBXJA2T_07573	2.874e-257	803.0	COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,2VMJK@28216|Betaproteobacteria,1KNFI@119065|unclassified Burkholderiales	28216|Betaproteobacteria	I	AMP-binding enzyme	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
HKD2_k127_2556865_23	748280.NH8B_2955	2.031e-54	198.0	COG2249@1|root,COG2249@2|Bacteria,1RA5X@1224|Proteobacteria,2VQSG@28216|Betaproteobacteria,2KTKU@206351|Neisseriales	206351|Neisseriales	S	Flavodoxin-like fold	-	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_2
HKD2_k127_2556865_12	107635.AZUO01000002_gene3811	1.539e-91	311.0	COG0778@1|root,COG0778@2|Bacteria,1RDJ6@1224|Proteobacteria,2U44Q@28211|Alphaproteobacteria,36ZEX@31993|Methylocystaceae	28211|Alphaproteobacteria	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
HKD2_k127_2556865_0	1265502.KB905929_gene2195	2.166e-263	824.0	COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,2VHEM@28216|Betaproteobacteria,4ABKM@80864|Comamonadaceae	28216|Betaproteobacteria	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	-	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
HKD2_k127_2556865_17	1276756.AUEX01000030_gene200	3.954e-77	261.0	COG1853@1|root,COG1853@2|Bacteria,1NB1B@1224|Proteobacteria,2VQ0V@28216|Betaproteobacteria,4AGUW@80864|Comamonadaceae	28216|Betaproteobacteria	S	Flavin reductase like domain	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
HKD2_k127_2556865_15	710421.Mycch_5260	1.23e-83	298.0	COG1020@1|root,COG1020@2|Bacteria,2GMHU@201174|Actinobacteria,235KS@1762|Mycobacteriaceae	201174|Actinobacteria	I	Belongs to the long-chain O-acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	DUF1298,WES_acyltransf
HKD2_k127_2556865_26	580332.Slit_2333	1.081e-50	183.0	COG3324@1|root,COG3324@2|Bacteria,1N7Q5@1224|Proteobacteria,2VT7E@28216|Betaproteobacteria,44WIN@713636|Nitrosomonadales	28216|Betaproteobacteria	S	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	ko:K06996	-	-	-	-	ko00000	-	-	-	Glyoxalase
HKD2_k127_2556865_14	468059.AUHA01000002_gene563	2.367e-84	305.0	COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,4NFW7@976|Bacteroidetes,1IR3J@117747|Sphingobacteriia	976|Bacteroidetes	K	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	ANAPC3,Guanylate_cyc,HTH_18,TPR_8
HKD2_k127_2556865_31	2074.JNYD01000008_gene1241	1.05e-28	134.0	COG1262@1|root,COG2273@1|root,COG1262@2|Bacteria,COG2273@2|Bacteria,2GN0F@201174|Actinobacteria,4E1IT@85010|Pseudonocardiales	201174|Actinobacteria	G	Sulfatase-modifying factor enzyme 1	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase
HKD2_k127_2556865_19	1123399.AQVE01000001_gene632	5.369e-75	256.0	COG2032@1|root,COG2032@2|Bacteria,1RGV4@1224|Proteobacteria,1S6KW@1236|Gammaproteobacteria,462EU@72273|Thiotrichales	72273|Thiotrichales	P	Copper/zinc superoxide dismutase (SODC)	-	-	1.15.1.1	ko:K04565	ko04146,ko04213,ko05014,ko05016,ko05020,map04146,map04213,map05014,map05016,map05020	-	-	-	ko00000,ko00001,ko01000	-	-	-	Sod_Cu
HKD2_k127_2556865_35	1174684.EBMC1_15679	1.36e-09	59.0	COG0501@1|root,COG0501@2|Bacteria,1MUXT@1224|Proteobacteria,2TVI9@28211|Alphaproteobacteria,2K2GU@204457|Sphingomonadales	204457|Sphingomonadales	O	CAAX prenyl protease N-terminal, five membrane helices	-	-	3.4.24.84	ko:K06013	ko00900,ko01130,map00900,map01130	-	R09845	RC00141	ko00000,ko00001,ko01000,ko01002,ko04147	-	-	-	Peptidase_M48,Peptidase_M48_N
HKD2_k127_2556865_13	1278309.KB907108_gene1621	1.415e-87	317.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1XHS3@135619|Oceanospirillales	135619|Oceanospirillales	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS,PAS_3,PAS_9,Response_reg
HKD2_k127_2556865_9	443143.GM18_4468	1.88e-110	394.0	COG0642@1|root,COG0745@1|root,COG0745@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,42M0Y@68525|delta/epsilon subdivisions,2WJCX@28221|Deltaproteobacteria,43SZR@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	histidine kinase HAMP region domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CHASE8,HAMP,HATPase_c,HisKA,Hpt,Response_reg
HKD2_k127_2556865_24	225849.swp_4046	6.192e-52	192.0	COG4635@1|root,COG4635@2|Bacteria,1RAH2@1224|Proteobacteria,1S372@1236|Gammaproteobacteria,2QBP7@267890|Shewanellaceae	1236|Gammaproteobacteria	CH	Flavodoxin domain	hemG	GO:0000166,GO:0003674,GO:0003824,GO:0004729,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0010181,GO:0016491,GO:0016627,GO:0016634,GO:0016635,GO:0018130,GO:0019438,GO:0032553,GO:0033013,GO:0033014,GO:0034641,GO:0036094,GO:0042168,GO:0042440,GO:0043167,GO:0043168,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0055114,GO:0070818,GO:0070819,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	1.3.5.3	ko:K00230	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R09489	RC00885	ko00000,ko00001,ko00002,ko01000	-	-	iAF1260.b3850,iAPECO1_1312.APECO1_2607,iB21_1397.B21_03690,iBWG_1329.BWG_3526,iE2348C_1286.E2348C_4162,iECABU_c1320.ECABU_c43520,iECBD_1354.ECBD_4175,iECB_1328.ECB_03741,iECDH10B_1368.ECDH10B_4039,iECDH1ME8569_1439.ECDH1ME8569_3727,iECD_1391.ECD_03741,iECED1_1282.ECED1_4552,iECH74115_1262.ECH74115_5289,iECIAI1_1343.ECIAI1_4043,iECNA114_1301.ECNA114_4159,iECOK1_1307.ECOK1_4319,iECS88_1305.ECS88_4298,iECSF_1327.ECSF_3707,iECSP_1301.ECSP_4903,iECs_1301.ECs4778,iEcDH1_1363.EcDH1_4131,iEcHS_1320.EcHS_A4073,iEcolC_1368.EcolC_4160,iG2583_1286.G2583_4648,iJO1366.b3850,iJR904.b3850,iLF82_1304.LF82_0981,iNRG857_1313.NRG857_19220,iSDY_1059.SDY_3895,iUMN146_1321.UM146_19505,iUMNK88_1353.UMNK88_4678,iUTI89_1310.UTI89_C4435,iY75_1357.Y75_RS17835,iZ_1308.Z5372,ic_1306.c4797	Flavodoxin_5
HKD2_k127_2556865_29	1515746.HR45_01485	1.208e-33	145.0	2BV15@1|root,32QDR@2|Bacteria,1RJ98@1224|Proteobacteria,1S88E@1236|Gammaproteobacteria,2QBY1@267890|Shewanellaceae	1236|Gammaproteobacteria	S	Prokaryotic cytochrome b561	-	-	-	-	-	-	-	-	-	-	-	-	Ni_hydr_CYTB
HKD2_k127_2556865_27	443144.GM21_3084	3.348e-47	190.0	COG2067@1|root,COG2067@2|Bacteria,1RFDS@1224|Proteobacteria,42UMQ@68525|delta/epsilon subdivisions,2WQY1@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	Protein of unknown function (DUF3187)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3187
HKD2_k127_2556865_36	234267.Acid_6678	6.063e-05	54.0	COG2823@1|root,COG2823@2|Bacteria,3Y7ZV@57723|Acidobacteria	57723|Acidobacteria	S	Periplasmic or secreted lipoprotein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2556865_10	861299.J421_1133	4.901e-108	366.0	COG0531@1|root,COG0531@2|Bacteria	2|Bacteria	E	amino acid	gadC	GO:0003333,GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0006865,GO:0006873,GO:0006885,GO:0008150,GO:0008509,GO:0008514,GO:0009987,GO:0015075,GO:0015171,GO:0015179,GO:0015291,GO:0015297,GO:0015318,GO:0015711,GO:0015807,GO:0015849,GO:0016020,GO:0016021,GO:0019725,GO:0022804,GO:0022857,GO:0030003,GO:0030004,GO:0030641,GO:0031224,GO:0031226,GO:0034220,GO:0042592,GO:0044425,GO:0044459,GO:0044464,GO:0045852,GO:0046942,GO:0046943,GO:0048878,GO:0050801,GO:0051179,GO:0051234,GO:0051453,GO:0051454,GO:0055067,GO:0055080,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071702,GO:0071705,GO:0071944,GO:0098656,GO:0098771,GO:1902475,GO:1903825,GO:1905039	-	ko:K20265	ko02024,map02024	-	-	-	ko00000,ko00001,ko02000	2.A.3.7.1,2.A.3.7.3	-	iEC042_1314.EC042_1624	AA_permease_2
HKD2_k127_2556865_4	1123487.KB892835_gene3616	6.277e-234	737.0	COG3634@1|root,COG3634@2|Bacteria,1MUKD@1224|Proteobacteria,2VJ01@28216|Betaproteobacteria,2KUP1@206389|Rhodocyclales	206389|Rhodocyclales	O	Alkyl hydroperoxide reductase	-	-	-	ko:K03387	-	-	-	-	ko00000,ko01000	-	-	-	Pyr_redox_2,Thioredoxin_3
HKD2_k127_2556865_11	522306.CAP2UW1_4457	3.014e-103	337.0	COG0450@1|root,COG0450@2|Bacteria,1MWPY@1224|Proteobacteria,2VI7T@28216|Betaproteobacteria,1KQ43@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	O	Redoxin	ahpC	-	1.11.1.15	ko:K03386	ko04214,map04214	-	-	-	ko00000,ko00001,ko01000,ko04147	-	-	-	1-cysPrx_C,AhpC-TSA
HKD2_k127_2556865_32	1049564.TevJSym_ao00470	1.104e-17	93.0	2C7GJ@1|root,32U2W@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2556865_6	675635.Psed_6333	5.688e-141	464.0	COG1024@1|root,COG1024@2|Bacteria,2HDTB@201174|Actinobacteria,4EEMZ@85010|Pseudonocardiales	201174|Actinobacteria	I	Enoyl-CoA hydratase/isomerase	echA2	-	4.2.1.17	ko:K01692	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
HKD2_k127_2556865_30	1502724.FF80_03878	6.047e-30	135.0	COG2076@1|root,COG2076@2|Bacteria,1MZ54@1224|Proteobacteria,2UBXR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	COG2076 Membrane transporters of cations and cationic drugs	qacE	-	-	ko:K03297	-	-	-	-	ko00000,ko02000	2.A.7.1	-	-	Multi_Drug_Res
HKD2_k127_2556865_28	1244869.H261_03113	5.24e-42	163.0	COG0500@1|root,COG2226@2|Bacteria,1RKQD@1224|Proteobacteria,2UAAJ@28211|Alphaproteobacteria,2JSQ3@204441|Rhodospirillales	204441|Rhodospirillales	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
HKD2_k127_2556865_21	1101190.ARWB01000001_gene60	3.698e-62	229.0	COG0483@1|root,COG0483@2|Bacteria,1PPJ0@1224|Proteobacteria,2TQTX@28211|Alphaproteobacteria,36X89@31993|Methylocystaceae	28211|Alphaproteobacteria	G	Inositol monophosphatase family	hisN	-	3.1.3.15,3.1.3.25,3.1.3.93	ko:K01092,ko:K18649	ko00053,ko00340,ko00521,ko00562,ko01100,ko01110,ko01230,ko04070,map00053,map00340,map00521,map00562,map01100,map01110,map01230,map04070	M00026,M00114,M00131	R01185,R01186,R01187,R03013,R07674	RC00017,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
HKD2_k127_2556865_25	1123023.JIAI01000001_gene6549	1.037e-50	192.0	COG0596@1|root,COG0596@2|Bacteria,2ICXR@201174|Actinobacteria	201174|Actinobacteria	S	alpha/beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
HKD2_k127_2556865_18	1472716.KBK24_0135510	2.28e-76	261.0	COG3576@1|root,COG3576@2|Bacteria,1NBWC@1224|Proteobacteria,2VKQ8@28216|Betaproteobacteria,1K2X4@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Pfam:Pyridox_oxidase	-	-	-	ko:K07006	-	-	-	-	ko00000	-	-	-	Putative_PNPOx
HKD2_k127_2556865_22	1123257.AUFV01000016_gene3480	1.129e-56	218.0	COG2050@1|root,COG2050@2|Bacteria,1QVFN@1224|Proteobacteria,1T2G5@1236|Gammaproteobacteria,1X6JP@135614|Xanthomonadales	135614|Xanthomonadales	Q	Thioesterase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT_3
HKD2_k127_2556865_33	1121920.AUAU01000006_gene323	1.104e-17	93.0	COG2706@1|root,COG2706@2|Bacteria	2|Bacteria	G	6-phosphogluconolactonase activity	-	-	-	-	-	-	-	-	-	-	-	-	Big_5,HemolysinCabind,VCBS
HKD2_k127_2559040_7	1267535.KB906767_gene1984	5.16e-105	346.0	COG0500@1|root,COG2226@2|Bacteria,3Y4HC@57723|Acidobacteria	57723|Acidobacteria	Q	Hypothetical methyltransferase	-	-	2.1.1.137	ko:K07755	-	-	-	-	ko00000,ko01000	-	-	-	Methyltransf_31
HKD2_k127_2559040_4	159087.Daro_2636	1.818e-172	548.0	COG0798@1|root,COG0798@2|Bacteria,1MUXY@1224|Proteobacteria,2VHWA@28216|Betaproteobacteria,2KUSU@206389|Rhodocyclales	28216|Betaproteobacteria	P	COG0798 Arsenite efflux pump ACR3 and related permeases	-	-	-	ko:K03325	-	-	-	-	ko00000,ko02000	2.A.59	-	-	SBF
HKD2_k127_2559040_14	395495.Lcho_3119	1.305e-08	58.0	COG0394@1|root,COG0394@2|Bacteria,1MWYQ@1224|Proteobacteria,2VPZB@28216|Betaproteobacteria,1KK59@119065|unclassified Burkholderiales	28216|Betaproteobacteria	T	Low molecular weight phosphotyrosine protein phosphatase	arsC	-	1.20.4.1	ko:K03741	-	-	-	-	ko00000,ko01000	-	-	-	LMWPc
HKD2_k127_2559040_12	243365.CV_2438	1.493e-34	136.0	COG0640@1|root,COG0640@2|Bacteria,1MZAU@1224|Proteobacteria,2VTXZ@28216|Betaproteobacteria,2KS3J@206351|Neisseriales	206351|Neisseriales	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	HTH_20
HKD2_k127_2559040_6	1537715.JQFJ01000002_gene2533	4.206e-155	514.0	COG1629@1|root,COG4771@2|Bacteria,1MUC1@1224|Proteobacteria,2VFU5@28211|Alphaproteobacteria,2KDZN@204457|Sphingomonadales	204457|Sphingomonadales	P	TonB dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
HKD2_k127_2559040_10	1380391.JIAS01000011_gene4670	4.106e-91	306.0	COG3791@1|root,COG3791@2|Bacteria,1MX4A@1224|Proteobacteria,2TSAN@28211|Alphaproteobacteria,2JV7J@204441|Rhodospirillales	204441|Rhodospirillales	S	Glutathione-dependent formaldehyde-activating enzyme	-	-	4.4.1.22	ko:K03396	ko00680,ko01120,ko01200,map00680,map01120,map01200	-	R06982	RC00069,RC01707	ko00000,ko00001,ko01000	-	-	-	GFA
HKD2_k127_2559040_8	83406.HDN1F_36100	2.438e-103	346.0	2CDI5@1|root,2Z7ZQ@2|Bacteria,1Q9TA@1224|Proteobacteria,1SKQ9@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2559040_5	710421.Mycch_5260	6.123e-161	520.0	COG1020@1|root,COG1020@2|Bacteria,2GMHU@201174|Actinobacteria,235KS@1762|Mycobacteriaceae	201174|Actinobacteria	I	Belongs to the long-chain O-acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	DUF1298,WES_acyltransf
HKD2_k127_2559040_1	748247.AZKH_p0572	1.956e-213	674.0	COG0183@1|root,COG0183@2|Bacteria,1MU8C@1224|Proteobacteria,2VNH1@28216|Betaproteobacteria,2M00T@206389|Rhodocyclales	28216|Betaproteobacteria	I	Beta-ketoacyl synthase, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Thiolase_C,Thiolase_N
HKD2_k127_2559040_9	1207075.PputUW4_02597	3.663e-102	341.0	COG4221@1|root,COG4221@2|Bacteria,1QTXD@1224|Proteobacteria,1T5Y9@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HKD2_k127_2559040_0	205922.Pfl01_2745	1.022e-268	848.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,1RMQ4@1236|Gammaproteobacteria,1YS6R@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	IQ	AMP-binding enzyme C-terminal domain	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
HKD2_k127_2559040_3	748247.AZKH_1932	3.96e-192	605.0	COG3268@1|root,COG3268@2|Bacteria,1MVI3@1224|Proteobacteria,2VQB7@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Saccharopine dehydrogenase NADP binding domain	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_10,Sacchrp_dh_NADP
HKD2_k127_2559040_2	748247.AZKH_p0569	1.754e-212	667.0	COG1960@1|root,COG1960@2|Bacteria,1P7WH@1224|Proteobacteria,2VMPJ@28216|Betaproteobacteria	28216|Betaproteobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M
HKD2_k127_2559040_11	1207075.PputUW4_02602	8.711e-67	239.0	COG4977@1|root,COG4977@2|Bacteria,1MXZQ@1224|Proteobacteria	1224|Proteobacteria	K	transcriptional regulator	-	-	-	ko:K07506	-	-	-	-	ko00000,ko03000	-	-	-	HTH_18,HTH_AraC
HKD2_k127_2568613_20	941449.dsx2_0422	1.101e-27	122.0	COG1529@1|root,COG2080@1|root,COG1529@2|Bacteria,COG2080@2|Bacteria,1QTTJ@1224|Proteobacteria,42NU9@68525|delta/epsilon subdivisions,2WKXG@28221|Deltaproteobacteria,2MAE0@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	2Fe-2S -binding	-	-	1.3.99.16	ko:K07303	-	-	-	-	ko00000,ko01000	-	-	-	Ald_Xan_dh_C2,Fer2,Fer2_2
HKD2_k127_2568613_23	373994.Riv7116_4720	2.505e-12	74.0	2BC3M@1|root,325NE@2|Bacteria,1G76C@1117|Cyanobacteria,1HNG9@1161|Nostocales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2568613_21	29581.BW37_04425	6.285e-21	93.0	2EK70@1|root,33DXD@2|Bacteria,1NA99@1224|Proteobacteria,2WCK9@28216|Betaproteobacteria,477U2@75682|Oxalobacteraceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2568613_9	1234364.AMSF01000048_gene2043	1.878e-154	497.0	COG2141@1|root,COG2141@2|Bacteria,1MVF0@1224|Proteobacteria,1RMCE@1236|Gammaproteobacteria,1X3Z8@135614|Xanthomonadales	135614|Xanthomonadales	C	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
HKD2_k127_2568613_17	1217714.F975_00618	1.699e-59	214.0	COG1917@1|root,COG1917@2|Bacteria,1RASA@1224|Proteobacteria,1T07I@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HKD2_k127_2568613_4	1192034.CAP_5407	7.882e-259	818.0	COG0243@1|root,COG0243@2|Bacteria,1NR6J@1224|Proteobacteria,42QKW@68525|delta/epsilon subdivisions,2WKH1@28221|Deltaproteobacteria,2YWTQ@29|Myxococcales	28221|Deltaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
HKD2_k127_2568613_18	1183438.GKIL_0813	1.534e-44	180.0	COG0265@1|root,COG3386@1|root,COG0265@2|Bacteria,COG3386@2|Bacteria	2|Bacteria	G	gluconolactonase activity	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PPC,Trypsin_2
HKD2_k127_2568613_2	1123487.KB892868_gene1204	4.482e-266	833.0	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,2VHGH@28216|Betaproteobacteria,2KUY0@206389|Rhodocyclales	206389|Rhodocyclales	S	COG0488 ATPase components of ABC transporters with duplicated ATPase domains	yheS	-	-	ko:K06158	-	-	-	-	ko00000,ko03012	-	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
HKD2_k127_2568613_16	1454004.AW11_01549	1.872e-72	248.0	COG3260@1|root,COG3260@2|Bacteria,1QUBE@1224|Proteobacteria,2VP8A@28216|Betaproteobacteria	28216|Betaproteobacteria	C	NADH ubiquinone oxidoreductase 20 kDa subunit	hyfI	-	-	-	-	-	-	-	-	-	-	-	Oxidored_q6
HKD2_k127_2568613_8	1454004.AW11_01548	7.965e-168	541.0	COG3261@1|root,COG3262@1|root,COG3261@2|Bacteria,COG3262@2|Bacteria,1QUBF@1224|Proteobacteria,2VJ0R@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Respiratory-chain NADH dehydrogenase, 49 Kd subunit	hyfG	-	-	-	-	-	-	-	-	-	-	-	Complex1_30kDa,Complex1_49kDa,NiFeSe_Hases
HKD2_k127_2568613_6	1122604.JONR01000030_gene1326	1.057e-239	748.0	COG0651@1|root,COG0651@2|Bacteria,1MVBA@1224|Proteobacteria,1RPB3@1236|Gammaproteobacteria,1XA5T@135614|Xanthomonadales	135614|Xanthomonadales	CP	Formate hydrogenlyase subunit 3 Multisubunit Na H antiporter, MnhD subunit	-	-	-	ko:K12141	-	-	-	-	ko00000,ko01000	-	-	-	Proton_antipo_M
HKD2_k127_2568613_15	1123393.KB891316_gene1981	2.698e-76	261.0	COG4237@1|root,COG4237@2|Bacteria,1NAT8@1224|Proteobacteria,2VJTI@28216|Betaproteobacteria,1KSIY@119069|Hydrogenophilales	119069|Hydrogenophilales	C	hydrogenase 4 membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2568613_10	1122604.JONR01000030_gene1324	9.411e-141	455.0	COG0650@1|root,COG0650@2|Bacteria,1MXV5@1224|Proteobacteria,1RPCY@1236|Gammaproteobacteria,1X98P@135614|Xanthomonadales	135614|Xanthomonadales	C	NADH dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	NADHdh
HKD2_k127_2568613_3	666685.R2APBS1_2169	1.842e-262	824.0	COG0651@1|root,COG0651@2|Bacteria,1MXRW@1224|Proteobacteria,1RM9Q@1236|Gammaproteobacteria,1XA2F@135614|Xanthomonadales	135614|Xanthomonadales	CP	Formate hydrogenlyase subunit 3 Multisubunit Na H antiporter, MnhD subunit	-	-	-	-	-	-	-	-	-	-	-	-	Proton_antipo_M
HKD2_k127_2568613_22	75379.Tint_0282	8.374e-17	82.0	COG3905@1|root,COG3905@2|Bacteria,1N7D2@1224|Proteobacteria,2VXUN@28216|Betaproteobacteria,1KP7J@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	PFAM CopG domain protein DNA-binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	RHH_1
HKD2_k127_2568613_11	1159870.KB907784_gene393	4.414e-119	407.0	COG1304@1|root,COG1304@2|Bacteria,1MUEZ@1224|Proteobacteria,2VHZV@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Dehydrogenase	-	-	1.1.99.31	ko:K15054	ko00627,ko01120,map00627,map01120	-	R04160,R07664	RC00240	ko00000,ko00001,ko01000	-	-	-	FMN_dh
HKD2_k127_2568613_12	105559.Nwat_1361	6.091e-112	370.0	COG0673@1|root,COG0673@2|Bacteria,1MV7C@1224|Proteobacteria,1SYTB@1236|Gammaproteobacteria,1WWFT@135613|Chromatiales	135613|Chromatiales	S	PFAM oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
HKD2_k127_2568613_7	187272.Mlg_1593	2.215e-179	585.0	COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,1RMSR@1236|Gammaproteobacteria,1WVZ6@135613|Chromatiales	135613|Chromatiales	M	Belongs to the peptidase S41A family	-	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	DUF3340,PDZ,Peptidase_S41
HKD2_k127_2568613_14	1121930.AQXG01000001_gene1204	1.808e-78	276.0	COG0845@1|root,COG0845@2|Bacteria,4NF23@976|Bacteroidetes	976|Bacteroidetes	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_D23
HKD2_k127_2568613_0	1121930.AQXG01000001_gene1203	0.0	1120.0	COG0841@1|root,COG0841@2|Bacteria,4NGCI@976|Bacteroidetes	976|Bacteroidetes	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
HKD2_k127_2568613_5	1121930.AQXG01000001_gene1202	3.427e-244	790.0	COG0841@1|root,COG0841@2|Bacteria,4NDZG@976|Bacteroidetes,1IPZZ@117747|Sphingobacteriia	976|Bacteroidetes	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
HKD2_k127_2568613_19	1266909.AUAG01000030_gene2418	1.936e-32	132.0	COG3151@1|root,COG3151@2|Bacteria,1NAPI@1224|Proteobacteria,1SEY8@1236|Gammaproteobacteria,1WYT2@135613|Chromatiales	135613|Chromatiales	S	Protein of unknown function (DUF1249)	-	-	-	ko:K09920	-	-	-	-	ko00000	-	-	-	DUF1249
HKD2_k127_2568613_13	1215092.PA6_007_01500	4.667e-94	316.0	COG1806@1|root,COG1806@2|Bacteria,1MUHU@1224|Proteobacteria,1RPHX@1236|Gammaproteobacteria,1YDKJ@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	S	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation dephosphorylation	ydiA	GO:0003674,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0030234,GO:0044424,GO:0044444,GO:0044464,GO:0050790,GO:0065007,GO:0065009,GO:0098772	2.7.11.33,2.7.4.28	ko:K09773	-	-	-	-	ko00000,ko01000	-	-	-	Kinase-PPPase
HKD2_k127_2568613_1	1245471.PCA10_37180	0.0	1049.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,1RP3T@1236|Gammaproteobacteria,1YEEV@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	G	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate	ppsA	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006094,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008986,GO:0009058,GO:0009987,GO:0016051,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016781,GO:0019318,GO:0019319,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046364,GO:0046872,GO:0071704,GO:1901576	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	iEcE24377_1341.EcE24377A_1919,iYL1228.KPN_02160	PEP-utilizers,PEP-utilizers_C,PPDK_N
HKD2_k127_2607406_1	1123253.AUBD01000005_gene218	1.561e-36	140.0	COG0007@1|root,COG1648@1|root,COG0007@2|Bacteria,COG1648@2|Bacteria,1MUI0@1224|Proteobacteria,1RM9V@1236|Gammaproteobacteria,1X3CH@135614|Xanthomonadales	135614|Xanthomonadales	H	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme	cysG	-	1.3.1.76,2.1.1.107,4.99.1.4	ko:K02302	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02864,R03194,R03947	RC00003,RC00871,RC01012,RC01034	ko00000,ko00001,ko00002,ko01000	-	-	-	CysG_dimeriser,NAD_binding_7,Sirohm_synth_M,TP_methylase
HKD2_k127_2607406_0	1403819.BATR01000040_gene1173	8.664e-187	602.0	COG1301@1|root,COG1301@2|Bacteria,46U9C@74201|Verrucomicrobia,2IUC1@203494|Verrucomicrobiae	203494|Verrucomicrobiae	C	Sodium:dicarboxylate symporter family	-	-	-	-	-	-	-	-	-	-	-	-	SDF
HKD2_k127_2607406_2	1298608.JCM18900_12546	1.972e-18	93.0	COG2267@1|root,COG2267@2|Bacteria,1RATF@1224|Proteobacteria,1S088@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	hydrolases or acyltransferases (alpha beta hydrolase superfamily)	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
HKD2_k127_2608981_0	765869.BDW_04655	2.509e-64	242.0	COG5184@1|root,COG5184@2|Bacteria,1R504@1224|Proteobacteria	1224|Proteobacteria	DZ	Alpha-tubulin suppressor and related RCC1 domain-containing	-	-	-	-	-	-	-	-	-	-	-	-	He_PIG,RCC1,RCC1_2
HKD2_k127_2608981_1	1324957.K933_16512	1.911e-17	96.0	COG3291@1|root,arCOG07560@1|root,arCOG07781@1|root,arCOG10187@1|root,arCOG02546@2157|Archaea,arCOG07560@2157|Archaea,arCOG07781@2157|Archaea,arCOG10187@2157|Archaea,2XYYY@28890|Euryarchaeota,23X3J@183963|Halobacteria	183963|Halobacteria	S	PKD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CARDB,PKD
HKD2_k127_2619868_0	414684.RC1_0236	7.485e-216	692.0	COG3573@1|root,COG3573@2|Bacteria,1R00Y@1224|Proteobacteria	1224|Proteobacteria	C	FAD dependent oxidoreductase	-	-	-	ko:K07077	-	-	-	-	ko00000	-	-	-	FAD_binding_2
HKD2_k127_2619868_1	298653.Franean1_6384	3.534e-28	123.0	COG0824@1|root,COG0824@2|Bacteria,2IMK1@201174|Actinobacteria	201174|Actinobacteria	S	Thioesterase	-	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT,4HBT_2
HKD2_k127_2631095_1	1123360.thalar_02885	3.063e-246	770.0	COG0843@1|root,COG0843@2|Bacteria,1R57U@1224|Proteobacteria,2U068@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Cytochrome C and Quinol oxidase polypeptide I	-	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
HKD2_k127_2631095_3	1123360.thalar_02884	4.874e-74	253.0	COG1622@1|root,COG1622@2|Bacteria,1NZNI@1224|Proteobacteria,2UJSY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	cytochrome c oxidase (Subunit II)	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2631095_4	1123360.thalar_02883	1.476e-13	73.0	2ERCE@1|root,33IY3@2|Bacteria,1NNN9@1224|Proteobacteria,2UXY5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2631095_2	864051.BurJ1DRAFT_0197	6.015e-130	422.0	COG0668@1|root,COG0668@2|Bacteria,1N596@1224|Proteobacteria,2VIWA@28216|Betaproteobacteria,1KKEY@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	mechanosensitive ion channel	mscS	-	-	ko:K03442,ko:K16052	-	-	-	-	ko00000,ko02000	1.A.23.2,1.A.23.4	-	-	MS_channel,TM_helix
HKD2_k127_2631095_0	396588.Tgr7_0004	1.089e-246	773.0	COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,1RNB2@1236|Gammaproteobacteria,1WVZ4@135613|Chromatiales	135613|Chromatiales	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
HKD2_k127_2680148_1	1280941.HY2_07895	4.62e-307	965.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2TRKS@28211|Alphaproteobacteria,43WXQ@69657|Hyphomonadaceae	28211|Alphaproteobacteria	I	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	acsA	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
HKD2_k127_2680148_27	441620.Mpop_4837	1.68e-50	184.0	COG0537@1|root,COG0537@2|Bacteria,1RDCJ@1224|Proteobacteria,2U956@28211|Alphaproteobacteria,1JUJ9@119045|Methylobacteriaceae	28211|Alphaproteobacteria	FG	PFAM histidine triad (HIT) protein	hit	-	-	ko:K02503	-	-	-	-	ko00000,ko04147	-	-	-	HIT
HKD2_k127_2680148_13	1163617.SCD_n00497	2.18e-108	368.0	COG2027@1|root,COG2027@2|Bacteria,1MW40@1224|Proteobacteria,2VH20@28216|Betaproteobacteria	28216|Betaproteobacteria	M	D-alanyl-D-alanine carboxypeptidase	dacB	-	3.4.16.4	ko:K07259	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	Peptidase_S13
HKD2_k127_2680148_29	754477.Q7C_1416	1.138e-45	175.0	COG2928@1|root,COG2928@2|Bacteria,1R79M@1224|Proteobacteria,1S6CC@1236|Gammaproteobacteria,46131@72273|Thiotrichales	72273|Thiotrichales	S	Protein of unknown function (DUF502)	-	-	-	-	-	-	-	-	-	-	-	-	DUF502
HKD2_k127_2680148_18	1318628.MARLIPOL_17004	2.332e-95	324.0	COG0491@1|root,COG0491@2|Bacteria,1MUDN@1224|Proteobacteria,1RMMG@1236|Gammaproteobacteria,464SC@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	COG0491 Zn-dependent hydrolases, including glyoxylases	ycbL	GO:0003674,GO:0003824,GO:0004416,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006082,GO:0006089,GO:0008150,GO:0008152,GO:0009056,GO:0009438,GO:0009987,GO:0016787,GO:0016788,GO:0016790,GO:0019243,GO:0019752,GO:0032787,GO:0042180,GO:0042182,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046185,GO:0051596,GO:0061727,GO:0071704,GO:1901575,GO:1901615	3.1.2.6	ko:K01069	ko00620,map00620	-	R01736	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	Lactamase_B
HKD2_k127_2680148_36	318161.Sden_2243	2.545e-16	83.0	2E9KN@1|root,333TE@2|Bacteria,1NCTP@1224|Proteobacteria,1SFMQ@1236|Gammaproteobacteria,2QCVA@267890|Shewanellaceae	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2680148_0	1128421.JAGA01000002_gene1368	6.168e-310	963.0	COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,2NNW4@2323|unclassified Bacteria	2|Bacteria	H	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses	nadE	GO:0003674,GO:0003824,GO:0003952,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008795,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016020,GO:0016874,GO:0016879,GO:0016880,GO:0016884,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0030312,GO:0034641,GO:0034654,GO:0040007,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.1.5,6.3.5.1	ko:K01916,ko:K01950	ko00760,ko01100,map00760,map01100	M00115	R00189,R00257	RC00010,RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase,NAD_synthase
HKD2_k127_2680148_7	1038869.AXAN01000036_gene2113	1.952e-152	491.0	28M5B@1|root,2ZAJ4@2|Bacteria,1R7Y9@1224|Proteobacteria,2VSMK@28216|Betaproteobacteria,1K5H6@119060|Burkholderiaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2680148_5	349521.HCH_05222	7.911e-189	595.0	COG1180@1|root,COG1180@2|Bacteria,1NQC1@1224|Proteobacteria,1RW3Z@1236|Gammaproteobacteria,1XI20@135619|Oceanospirillales	135619|Oceanospirillales	O	Pyruvate formate lyase-activating protein	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Radical_SAM
HKD2_k127_2680148_21	1123393.KB891333_gene2646	1.17e-78	273.0	COG1355@1|root,COG2078@1|root,COG1355@2|Bacteria,COG2078@2|Bacteria,1MXK5@1224|Proteobacteria,2VKXP@28216|Betaproteobacteria,1KS3P@119069|Hydrogenophilales	119069|Hydrogenophilales	S	Memo-like protein	-	-	-	ko:K06990	-	-	-	-	ko00000,ko04812	-	-	-	AMMECR1,Memo
HKD2_k127_2680148_31	1121035.AUCH01000017_gene2280	8.712e-42	162.0	COG2078@1|root,COG2078@2|Bacteria,1RJP4@1224|Proteobacteria,2VRE4@28216|Betaproteobacteria,2KWM9@206389|Rhodocyclales	206389|Rhodocyclales	S	AMMECR1	-	-	-	-	-	-	-	-	-	-	-	-	AMMECR1
HKD2_k127_2680148_37	314287.GB2207_04039	7.598e-14	85.0	2C612@1|root,32RGH@2|Bacteria,1RGYZ@1224|Proteobacteria,1S8MM@1236|Gammaproteobacteria,1J6RN@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2680148_39	1415778.JQMM01000001_gene1134	5.81e-13	78.0	2C5F4@1|root,31I7F@2|Bacteria,1RHUH@1224|Proteobacteria,1S7M2@1236|Gammaproteobacteria,1J6PV@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2680148_17	876044.IMCC3088_857	1.768e-95	338.0	COG2304@1|root,COG2304@2|Bacteria,1QBPM@1224|Proteobacteria,1RQIU@1236|Gammaproteobacteria,1J4PZ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Secreted protein, containing von Willebrand factor (VWF) type	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2680148_15	1265313.HRUBRA_00929	8.583e-98	331.0	COG1196@1|root,COG1196@2|Bacteria,1R4BS@1224|Proteobacteria,1S13B@1236|Gammaproteobacteria,1J7UD@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	D	von Willebrand factor (VWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	VWA_2
HKD2_k127_2680148_30	1415778.JQMM01000001_gene1137	4.271e-43	175.0	2ASXF@1|root,31ID0@2|Bacteria,1RM30@1224|Proteobacteria,1S8I2@1236|Gammaproteobacteria,1JAB6@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2680148_19	1415778.JQMM01000001_gene1138	3.04e-86	297.0	COG0811@1|root,COG0811@2|Bacteria,1NXZ9@1224|Proteobacteria,1S154@1236|Gammaproteobacteria,1J4YC@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	U	COG0811 Biopolymer transport proteins	-	-	-	-	-	-	-	-	-	-	-	-	MotA_ExbB
HKD2_k127_2680148_8	1415778.JQMM01000001_gene1140	2.464e-149	504.0	COG1262@1|root,COG1262@2|Bacteria,1NQ5K@1224|Proteobacteria,1RQVS@1236|Gammaproteobacteria,1J55S@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Sulfatase-modifying factor enzyme 1	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase,PEGA
HKD2_k127_2680148_25	1415778.JQMM01000001_gene1141	5.596e-54	215.0	COG0457@1|root,COG0457@2|Bacteria,1RC07@1224|Proteobacteria,1S36N@1236|Gammaproteobacteria,1J5XV@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_8
HKD2_k127_2680148_34	452652.KSE_21030	1.089e-31	144.0	COG0515@1|root,COG0515@2|Bacteria,2GMPZ@201174|Actinobacteria,2M21I@2063|Kitasatospora	201174|Actinobacteria	KLT	Protein tyrosine kinase	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HKD2_k127_2680148_16	1415779.JOMH01000001_gene183	3.856e-96	329.0	28MBM@1|root,2ZAQ2@2|Bacteria,1R5V6@1224|Proteobacteria,1S0K0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2680148_40	1415778.JQMM01000001_gene1143	1.126e-12	80.0	2EDVS@1|root,337QX@2|Bacteria,1NEZW@1224|Proteobacteria,1SCKV@1236|Gammaproteobacteria,1J6US@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2680148_28	314287.GB2207_04099	4.741e-47	180.0	29B18@1|root,2ZY02@2|Bacteria,1REMG@1224|Proteobacteria,1S4B1@1236|Gammaproteobacteria,1JA2W@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2680148_11	1163398.AJJP01000071_gene2656	2.46e-128	422.0	COG1533@1|root,COG1533@2|Bacteria,1MW0H@1224|Proteobacteria,1RQNF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
HKD2_k127_2680148_10	448385.sce1009	6.042e-144	468.0	COG0477@1|root,COG2814@2|Bacteria,1QTX0@1224|Proteobacteria,42QJX@68525|delta/epsilon subdivisions,2WKPN@28221|Deltaproteobacteria,2Z26U@29|Myxococcales	28221|Deltaproteobacteria	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
HKD2_k127_2680148_4	743721.Psesu_1900	2.363e-218	695.0	COG4805@1|root,COG4805@2|Bacteria,1R5EP@1224|Proteobacteria,1RRS6@1236|Gammaproteobacteria,1X3WH@135614|Xanthomonadales	135614|Xanthomonadales	S	Bacterial protein of unknown function (DUF885)	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
HKD2_k127_2680148_20	987059.RBXJA2T_05838	3.552e-81	297.0	COG2267@1|root,COG2267@2|Bacteria,1QTAP@1224|Proteobacteria,2VMEV@28216|Betaproteobacteria,1KIZ7@119065|unclassified Burkholderiales	28216|Betaproteobacteria	I	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
HKD2_k127_2680148_3	765911.Thivi_3675	1.707e-227	714.0	COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,1RMY6@1236|Gammaproteobacteria,1WWPJ@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA	ilvA	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP,Thr_dehydrat_C
HKD2_k127_2680148_24	1120966.AUBU01000005_gene3545	3.529e-54	208.0	COG0520@1|root,COG0520@2|Bacteria,4NF4G@976|Bacteroidetes,47M48@768503|Cytophagia	976|Bacteroidetes	E	Aminotransferase class-V	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
HKD2_k127_2680148_35	196162.Noca_4081	1.845e-28	124.0	COG0596@1|root,COG0596@2|Bacteria,2GRVV@201174|Actinobacteria	201174|Actinobacteria	S	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
HKD2_k127_2680148_9	287.DR97_2901	6.881e-149	485.0	COG0174@1|root,COG0174@2|Bacteria,1MU6V@1224|Proteobacteria,1RPNZ@1236|Gammaproteobacteria,1YD8Z@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	E	Glutamine synthetase, catalytic domain	-	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C
HKD2_k127_2680148_38	392499.Swit_1437	1.748e-13	84.0	COG0625@1|root,COG0625@2|Bacteria,1Q05U@1224|Proteobacteria,2TTDK@28211|Alphaproteobacteria,2KD17@204457|Sphingomonadales	204457|Sphingomonadales	O	Glutathione S-transferase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	GST_C,GST_C_2,GST_N_3
HKD2_k127_2680148_12	1384054.N790_06975	3.049e-117	392.0	COG0812@1|root,COG0812@2|Bacteria,1MXDH@1224|Proteobacteria,1RNXK@1236|Gammaproteobacteria,1X3P6@135614|Xanthomonadales	135614|Xanthomonadales	M	Cell wall formation	murB	-	1.3.1.98	ko:K00075	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R03191,R03192	RC02639	ko00000,ko00001,ko01000,ko01011	-	-	-	FAD_binding_4,MurB_C
HKD2_k127_2680148_33	234267.Acid_0524	2.383e-37	150.0	COG1651@1|root,COG1651@2|Bacteria	2|Bacteria	O	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_4
HKD2_k127_2680148_14	1385517.N800_14085	3.539e-106	359.0	COG2059@1|root,COG2059@2|Bacteria,1MUBW@1224|Proteobacteria,1RPNP@1236|Gammaproteobacteria,1X53Q@135614|Xanthomonadales	135614|Xanthomonadales	P	Chromate transporter	-	-	-	ko:K07240	-	-	-	-	ko00000,ko02000	2.A.51.1	-	-	Chromate_transp
HKD2_k127_2680148_2	1122604.JONR01000025_gene4590	7.176e-296	918.0	COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,1RMQQ@1236|Gammaproteobacteria,1X45G@135614|Xanthomonadales	135614|Xanthomonadales	E	Acetolactate synthase	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
HKD2_k127_2680148_32	765914.ThisiDRAFT_0207	2.689e-41	161.0	COG0440@1|root,COG0440@2|Bacteria,1RAGN@1224|Proteobacteria,1S20I@1236|Gammaproteobacteria,1WXGS@135613|Chromatiales	135613|Chromatiales	E	TIGRFAM Acetolactate synthase, small subunit	-	-	2.2.1.6	ko:K01653	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT_5,ALS_ss_C
HKD2_k127_2680148_22	251229.Chro_4001	2.681e-73	252.0	COG0625@1|root,COG0625@2|Bacteria,1G34I@1117|Cyanobacteria,3VHY7@52604|Pleurocapsales	1117|Cyanobacteria	O	Glutathione S-transferase, C-terminal domain	-	-	2.5.1.18	ko:K00799,ko:K11209	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C,GST_N,GST_N_3
HKD2_k127_2680148_26	1323361.JPOC01000028_gene3869	6.358e-52	189.0	COG0824@1|root,COG0824@2|Bacteria,2IJV6@201174|Actinobacteria,4G0ED@85025|Nocardiaceae	201174|Actinobacteria	S	Thioesterase-like superfamily	-	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT,4HBT_2
HKD2_k127_2680148_6	1120972.AUMH01000002_gene2736	1.047e-156	502.0	COG1062@1|root,COG1062@2|Bacteria,1TP8E@1239|Firmicutes,4HAH9@91061|Bacilli	91061|Bacilli	C	alcohol dehydrogenase	adhC	-	1.1.1.1,1.1.1.90	ko:K00001,ko:K00055	ko00010,ko00071,ko00350,ko00360,ko00622,ko00623,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00360,map00622,map00623,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	M00537,M00538	R00623,R00754,R01763,R02124,R02611,R04304,R04805,R04880,R05233,R05234,R05282,R05347,R05348,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
HKD2_k127_2680148_23	1384054.N790_12970	3.133e-65	230.0	COG4775@1|root,COG4775@2|Bacteria,1PT0R@1224|Proteobacteria,1RPWY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	COG4775 Outer membrane protein protective antigen OMA87	-	-	-	-	-	-	-	-	-	-	-	-	Bac_surface_Ag,ShlB
HKD2_k127_2757579_0	62928.azo0159	1.797e-250	776.0	COG0055@1|root,COG0055@2|Bacteria,1MUFU@1224|Proteobacteria,2VHDZ@28216|Betaproteobacteria,2KUDB@206389|Rhodocyclales	206389|Rhodocyclales	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits	atpD	-	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_N
HKD2_k127_2757579_1	757424.Hsero_4361	1.28e-46	171.0	COG0355@1|root,COG0355@2|Bacteria,1RHE4@1224|Proteobacteria,2VR2R@28216|Betaproteobacteria,474C5@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpC	-	-	ko:K02114	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_DE,ATP-synt_DE_N
HKD2_k127_2757579_2	555778.Hneap_0086	8.15e-08	54.0	2EDPA@1|root,337IZ@2|Bacteria,1NF70@1224|Proteobacteria,1SFC9@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2759872_3	1112214.AHIS01000131_gene2624	5.664e-118	390.0	COG3505@1|root,COG3505@2|Bacteria,1PWIG@1224|Proteobacteria,2TSDY@28211|Alphaproteobacteria,2K29R@204457|Sphingomonadales	204457|Sphingomonadales	U	Type IV secretory pathway VirD4	-	-	-	-	-	-	-	-	-	-	-	-	TrwB_AAD_bind
HKD2_k127_2759872_8	1122604.JONR01000053_gene4482	8.398e-06	58.0	2DCSB@1|root,2ZF5K@2|Bacteria,1P7B4@1224|Proteobacteria,1SWB0@1236|Gammaproteobacteria,1XBAS@135614|Xanthomonadales	135614|Xanthomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2759872_2	1218084.BBJK01000057_gene4321	4.779e-138	466.0	COG2132@1|root,COG2132@2|Bacteria,1MU0J@1224|Proteobacteria,2VJA1@28216|Betaproteobacteria,1KGJR@119060|Burkholderiaceae	28216|Betaproteobacteria	Q	PFAM multicopper oxidase type	-	-	1.3.3.5	ko:K08100	ko00860,ko01110,map00860,map01110	-	R02394	RC01983	ko00000,ko00001,ko01000	-	-	-	Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3
HKD2_k127_2759872_6	717785.HYPMC_0876	8.41e-41	154.0	COG3439@1|root,COG3439@2|Bacteria,1RH9Z@1224|Proteobacteria,2UAEV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Domain of unknown function DUF302	-	-	-	-	-	-	-	-	-	-	-	-	DUF302
HKD2_k127_2759872_4	644801.Psest_1404	2.016e-92	307.0	COG0500@1|root,COG0500@2|Bacteria,1REJ2@1224|Proteobacteria,1S2QF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	Nodulation protein S (NodS)	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
HKD2_k127_2759872_1	702113.PP1Y_AT22654	5.877e-235	743.0	COG0672@1|root,COG2010@1|root,COG0672@2|Bacteria,COG2010@2|Bacteria,1MXHM@1224|Proteobacteria,2U17C@28211|Alphaproteobacteria,2K07Y@204457|Sphingomonadales	204457|Sphingomonadales	P	permease	-	-	-	ko:K07243	-	-	-	-	ko00000,ko02000	2.A.108.1,2.A.108.2	-	-	Cytochrome_CBB3,FTR1
HKD2_k127_2759872_0	535289.Dtpsy_2148	0.0	1023.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,2VHKE@28216|Betaproteobacteria,4AAHB@80864|Comamonadaceae	28216|Betaproteobacteria	P	heavy metal translocating P-type ATPase	-	-	3.6.3.3,3.6.3.5	ko:K01534	-	-	-	-	ko00000,ko01000	3.A.3.6	-	-	E1-E2_ATPase,HMA,Hydrolase
HKD2_k127_2759872_5	1211114.ALIP01000120_gene1071	1.301e-52	188.0	COG0789@1|root,COG0789@2|Bacteria,1MZ3P@1224|Proteobacteria,1SBZS@1236|Gammaproteobacteria,1X6X3@135614|Xanthomonadales	135614|Xanthomonadales	K	transcriptional	-	-	-	-	-	-	-	-	-	-	-	-	MerR,MerR-DNA-bind
HKD2_k127_2773712_3	1116369.KB890024_gene1718	1.04e-50	186.0	COG1174@1|root,COG1174@2|Bacteria,1MX8D@1224|Proteobacteria,2VETG@28211|Alphaproteobacteria,43IGM@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	yehW	-	-	ko:K05845,ko:K05846	ko02010,map02010	M00209	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	BPD_transp_1
HKD2_k127_2773712_1	224914.BMEI1727	6.111e-122	412.0	COG1125@1|root,COG1125@2|Bacteria,1QTUC@1224|Proteobacteria,2TTMA@28211|Alphaproteobacteria,1J1R4@118882|Brucellaceae	28211|Alphaproteobacteria	E	ATPases associated with a variety of cellular activities	yehX	GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0015695,GO:0015696,GO:0015697,GO:0015838,GO:0031460,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0072337	-	ko:K05847	ko02010,map02010	M00209	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	ABC_tran
HKD2_k127_2773712_2	1336243.JAEA01000012_gene2997	1.059e-103	347.0	COG1732@1|root,COG1732@2|Bacteria,1MV9N@1224|Proteobacteria,2TTY6@28211|Alphaproteobacteria,1JR1V@119045|Methylobacteriaceae	28211|Alphaproteobacteria	M	PFAM Substrate-binding region of ABC-type glycine betaine transport system	osmF	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006950,GO:0006970,GO:0006972,GO:0008150,GO:0009628,GO:0009987,GO:0015695,GO:0015696,GO:0015697,GO:0015838,GO:0016020,GO:0031460,GO:0033554,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0071214,GO:0071470,GO:0071474,GO:0071702,GO:0071705,GO:0071944,GO:0072337,GO:0104004	-	ko:K05845	ko02010,map02010	M00209	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	OpuAC
HKD2_k127_2773712_0	1380394.JADL01000010_gene4293	1.163e-301	951.0	COG0404@1|root,COG0665@1|root,COG0404@2|Bacteria,COG0665@2|Bacteria,1MUXJ@1224|Proteobacteria,2TRGS@28211|Alphaproteobacteria,2JR4V@204441|Rhodospirillales	204441|Rhodospirillales	E	FAD dependent oxidoreductase central domain	-	-	-	-	-	-	-	-	-	-	-	-	DAO,FAO_M,GCV_T,GCV_T_C
HKD2_k127_2773712_4	194867.ALBQ01000011_gene175	5.079e-12	68.0	COG4188@1|root,COG4188@2|Bacteria,1MW6H@1224|Proteobacteria,2TTRH@28211|Alphaproteobacteria,2K3TE@204457|Sphingomonadales	204457|Sphingomonadales	S	Platelet-activating factor acetylhydrolase, isoform II	-	-	-	-	-	-	-	-	-	-	-	-	PAF-AH_p_II
HKD2_k127_2780683_0	1121377.KB906402_gene3232	4.579e-118	418.0	COG0457@1|root,COG3899@1|root,COG0457@2|Bacteria,COG3899@2|Bacteria	2|Bacteria	T	PFAM Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	AAA_16,Trans_reg_C
HKD2_k127_2780683_1	697282.Mettu_2218	2.778e-24	106.0	COG1531@1|root,COG1531@2|Bacteria,1N7PM@1224|Proteobacteria,1SRSR@1236|Gammaproteobacteria	1236|Gammaproteobacteria	AJ	Protein of unknown function (DUF504)	-	-	-	-	-	-	-	-	-	-	-	-	DUF504
HKD2_k127_2780683_2	247634.GPB2148_57	4.577e-05	51.0	COG4774@1|root,COG4774@2|Bacteria,1NMCN@1224|Proteobacteria,1T1GZ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	receptor	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
HKD2_k127_2788304_2	1117314.PCIT_14881	1.748e-30	124.0	COG0457@1|root,COG0457@2|Bacteria,1N9D5@1224|Proteobacteria,1SAKR@1236|Gammaproteobacteria,2Q3IU@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2788304_1	1123504.JQKD01000032_gene4502	3.793e-50	190.0	28ME7@1|root,2ZARX@2|Bacteria,1R90X@1224|Proteobacteria,2VNB6@28216|Betaproteobacteria,4AA7V@80864|Comamonadaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
HKD2_k127_2788304_0	1267533.KB906735_gene4667	5.289e-54	192.0	COG1858@1|root,COG1858@2|Bacteria	2|Bacteria	C	electron transfer activity	-	-	-	-	-	-	-	-	-	-	-	-	CCP_MauG
HKD2_k127_2796831_5	391615.ABSJ01000004_gene643	2.025e-34	136.0	COG2121@1|root,COG2121@2|Bacteria,1MZID@1224|Proteobacteria,1T7TI@1236|Gammaproteobacteria,1JB79@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Domain of unknown function (DUF374)	-	-	-	-	-	-	-	-	-	-	-	-	DUF374
HKD2_k127_2796831_7	561175.KB894095_gene2371	7.899e-08	66.0	COG2091@1|root,COG2091@2|Bacteria,2IQ65@201174|Actinobacteria,4EJHZ@85012|Streptosporangiales	201174|Actinobacteria	H	4'-phosphopantetheinyl transferase superfamily	-	-	-	ko:K06133	ko00770,map00770	-	R01625	RC00002	ko00000,ko00001,ko01000	-	-	-	ACPS
HKD2_k127_2796831_1	232721.Ajs_3072	8.005e-119	396.0	COG2124@1|root,COG2124@2|Bacteria,1MV75@1224|Proteobacteria,2WGHK@28216|Betaproteobacteria,4AF4Y@80864|Comamonadaceae	28216|Betaproteobacteria	C	PFAM Cytochrome P450	-	-	1.14.14.1,1.6.2.4	ko:K14338	ko00071,ko00380,ko00627,ko01120,map00071,map00380,map00627,map01120	-	R03629,R04121,R05259	RC00046,RC01311	ko00000,ko00001,ko00199,ko01000	-	-	-	FAD_binding_1,Flavodoxin_1,NAD_binding_1,p450
HKD2_k127_2796831_0	1304275.C41B8_14930	1.581e-185	601.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,1T1II@1236|Gammaproteobacteria	1236|Gammaproteobacteria	IQ	COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II	-	-	-	ko:K13614	-	-	-	-	ko00000,ko01004,ko01008	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,NAD_binding_4,PP-binding,PS-DH,Thioesterase,ketoacyl-synt
HKD2_k127_2796831_2	1237149.C900_02855	1.135e-43	171.0	COG1560@1|root,COG1560@2|Bacteria,4NGQU@976|Bacteroidetes,47MHM@768503|Cytophagia	976|Bacteroidetes	M	Lipid A biosynthesis acyltransferase	waaM	-	2.3.1.241	ko:K02517	ko00540,ko01100,map00540,map01100	M00060	R05146	RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Lip_A_acyltrans
HKD2_k127_2796831_4	1166018.FAES_4852	8.625e-36	147.0	COG1560@1|root,COG1560@2|Bacteria,4NGQU@976|Bacteroidetes,47MHM@768503|Cytophagia	976|Bacteroidetes	M	Lipid A biosynthesis acyltransferase	waaM	-	2.3.1.241	ko:K02517	ko00540,ko01100,map00540,map01100	M00060	R05146	RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Lip_A_acyltrans
HKD2_k127_2796831_3	1158760.AQXP01000053_gene1421	7.174e-36	140.0	COG0735@1|root,COG0735@2|Bacteria,1RH58@1224|Proteobacteria,1SAXA@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	belongs to the Fur family	-	-	-	ko:K09826	-	-	-	-	ko00000,ko03000	-	-	-	FUR
HKD2_k127_2796831_6	1158762.KB898045_gene450	4.913e-23	107.0	COG4970@1|root,COG4970@2|Bacteria,1N7RS@1224|Proteobacteria,1SCFB@1236|Gammaproteobacteria,1WYQF@135613|Chromatiales	135613|Chromatiales	NU	Type II transport protein GspH	-	-	-	ko:K08084	-	-	-	-	ko00000,ko02044	3.A.15.2	-	-	GspH,N_methyl
HKD2_k127_2843192_5	1188252.AJYK01000022_gene1342	4.052e-34	134.0	COG0356@1|root,COG0356@2|Bacteria,1MV87@1224|Proteobacteria,1RPHK@1236|Gammaproteobacteria,1XT0C@135623|Vibrionales	135623|Vibrionales	C	it plays a direct role in the translocation of protons across the membrane	atpB	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016021,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0042777,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045263,GO:0045264,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1	-	-	ATP-synt_A
HKD2_k127_2843192_2	105559.Nwat_3137	1.672e-96	324.0	COG1475@1|root,COG1475@2|Bacteria,1MW2E@1224|Proteobacteria,1RN65@1236|Gammaproteobacteria,1WWNZ@135613|Chromatiales	135613|Chromatiales	K	Belongs to the ParB family	-	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
HKD2_k127_2843192_6	269796.Rru_A2472	1.21e-12	81.0	2AUKY@1|root,31K9Q@2|Bacteria,1RH1X@1224|Proteobacteria,2UBK3@28211|Alphaproteobacteria,2JTF2@204441|Rhodospirillales	204441|Rhodospirillales	S	Lipid A 3-O-deacylase (PagL)	-	-	-	-	-	-	-	-	-	-	-	-	PagL
HKD2_k127_2843192_1	270374.MELB17_00145	1.161e-98	345.0	COG1192@1|root,COG1192@2|Bacteria,1MV43@1224|Proteobacteria,1RNJK@1236|Gammaproteobacteria,464DZ@72275|Alteromonadaceae	1236|Gammaproteobacteria	D	COG1192 ATPases involved in chromosome partitioning	parA	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
HKD2_k127_2843192_4	396588.Tgr7_3315	8.494e-47	191.0	COG0357@1|root,COG0357@2|Bacteria,1MY0K@1224|Proteobacteria,1RMRZ@1236|Gammaproteobacteria,1WXDT@135613|Chromatiales	135613|Chromatiales	J	Specifically methylates the N7 position of guanine in position 527 of 16S rRNA	rsmG	-	2.1.1.170	ko:K03501	-	-	-	-	ko00000,ko01000,ko03009,ko03036	-	-	-	GidB
HKD2_k127_2843192_0	349124.Hhal_1070	9.085e-213	670.0	COG2079@1|root,COG2079@2|Bacteria,1MUIG@1224|Proteobacteria,1RPQN@1236|Gammaproteobacteria,1WWIP@135613|Chromatiales	135613|Chromatiales	S	2-methylcitrate dehydratase	prpD	-	4.2.1.79	ko:K01720	ko00640,map00640	-	R04424	RC01152	ko00000,ko00001,ko01000	-	-	-	MmgE_PrpD
HKD2_k127_2843192_3	402626.Rpic_3858	6.986e-65	223.0	COG2828@1|root,COG2828@2|Bacteria,1MXVV@1224|Proteobacteria,2VJAW@28216|Betaproteobacteria,1K18H@119060|Burkholderiaceae	28216|Betaproteobacteria	S	AcnD-accessory protein PrpF	prpF	-	-	ko:K09788	ko00640,map00640	-	R11264	RC03405	ko00000,ko00001,ko01000	-	-	-	PrpF
HKD2_k127_2849306_3	392500.Swoo_0391	1.508e-05	51.0	2DBXS@1|root,2ZBR1@2|Bacteria,1RBUD@1224|Proteobacteria,1S1ZK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2849306_1	485913.Krac_7219	4.934e-149	479.0	28JHC@1|root,2Z9AX@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_18
HKD2_k127_2849306_0	391038.Bphy_2359	4.775e-168	538.0	COG0604@1|root,COG0604@2|Bacteria,1R8NX@1224|Proteobacteria,2W0KY@28216|Betaproteobacteria,1K4PK@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Alcohol dehydrogenase GroES-like domain	-	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N_2
HKD2_k127_2849306_2	1185652.USDA257_c40280	3.748e-21	92.0	COG3791@1|root,COG3791@2|Bacteria,1RH2A@1224|Proteobacteria,2U731@28211|Alphaproteobacteria,4BE1G@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Glutathione-dependent formaldehyde-activating enzyme	-	-	-	-	-	-	-	-	-	-	-	-	GFA
HKD2_k127_2851193_2	471856.Jden_0544	5.419e-07	54.0	COG1894@1|root,COG1894@2|Bacteria,2GMMC@201174|Actinobacteria	201174|Actinobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain	nuoF	-	1.6.5.3	ko:K00335	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_51K,NADH_4Fe-4S,SLBB
HKD2_k127_2851193_1	9371.XP_004714121.1	5.307e-42	164.0	COG1905@1|root,KOG3196@2759|Eukaryota,38G5A@33154|Opisthokonta,3BI24@33208|Metazoa,3CSRY@33213|Bilateria,48532@7711|Chordata,48WTW@7742|Vertebrata,3JCA4@40674|Mammalia,352M3@311790|Afrotheria	33208|Metazoa	C	NADH dehydrogenase (ubiquinone) flavoprotein 2	NDUFV2	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005746,GO:0005747,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006996,GO:0007005,GO:0007275,GO:0007399,GO:0007507,GO:0008137,GO:0008150,GO:0008152,GO:0009055,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009888,GO:0009987,GO:0010257,GO:0014706,GO:0015980,GO:0016020,GO:0016043,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0019866,GO:0022607,GO:0022900,GO:0022904,GO:0030964,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0032501,GO:0032502,GO:0032981,GO:0032991,GO:0033108,GO:0034622,GO:0034641,GO:0042773,GO:0042775,GO:0043209,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044281,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044444,GO:0044446,GO:0044455,GO:0044464,GO:0045271,GO:0045333,GO:0046034,GO:0046483,GO:0048513,GO:0048731,GO:0048738,GO:0048856,GO:0050136,GO:0055086,GO:0055114,GO:0060537,GO:0065003,GO:0070469,GO:0071704,GO:0071840,GO:0072359,GO:0072521,GO:0098796,GO:0098798,GO:0098800,GO:0098803,GO:1901135,GO:1901360,GO:1901564,GO:1902494,GO:1990204	1.6.5.3,1.6.99.3	ko:K03943	ko00190,ko01100,ko04714,ko04723,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map04714,map04723,map04932,map05010,map05012,map05016	M00143	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1.6	-	-	2Fe-2S_thioredx
HKD2_k127_2851193_0	443143.GM18_4387	1.332e-141	459.0	COG0649@1|root,COG0649@2|Bacteria,1MVIN@1224|Proteobacteria,42M9G@68525|delta/epsilon subdivisions,2WIS7@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoD	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044464,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072521,GO:1901135,GO:1901360,GO:1901564	1.6.5.3	ko:K00333,ko:K13378,ko:K13380	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa,Complex1_49kDa,NiFeSe_Hases
HKD2_k127_2851193_3	1177179.A11A3_09765	4.19e-06	49.0	COG0279@1|root,COG0279@2|Bacteria,1NJ8X@1224|Proteobacteria,1RS1Y@1236|Gammaproteobacteria,1XI6S@135619|Oceanospirillales	135619|Oceanospirillales	G	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate	gmhA	-	5.3.1.28	ko:K03271,ko:K12961	ko00540,ko01100,map00540,map01100	M00064	R05645,R09768,R09769	RC00434	ko00000,ko00001,ko00002,ko01000,ko01005,ko03036	-	-	-	SIS_2
HKD2_k127_285562_2	489825.LYNGBM3L_49280	8.995e-153	491.0	COG1012@1|root,COG1012@2|Bacteria,1G2U1@1117|Cyanobacteria,1H7XG@1150|Oscillatoriales	1117|Cyanobacteria	C	Belongs to the aldehyde dehydrogenase family	-	-	1.2.1.3	ko:K00128	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
HKD2_k127_285562_1	1209984.BN978_01673	9.832e-222	702.0	COG4805@1|root,COG4805@2|Bacteria,2GMUR@201174|Actinobacteria,237JI@1762|Mycobacteriaceae	201174|Actinobacteria	S	Bacterial protein of unknown function (DUF885)	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
HKD2_k127_285562_5	1411123.JQNH01000001_gene2640	9.898e-72	246.0	COG2128@1|root,COG2128@2|Bacteria,1MUDM@1224|Proteobacteria,2TTY5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity	-	-	-	-	-	-	-	-	-	-	-	-	CMD
HKD2_k127_285562_0	107635.AZUO01000005_gene4310	3.374e-242	767.0	COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,2TQSC@28211|Alphaproteobacteria,36ZBN@31993|Methylocystaceae	28211|Alphaproteobacteria	L	UvrD-like helicase C-terminal domain	uvrD	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
HKD2_k127_285562_6	1122603.ATVI01000006_gene70	2.799e-59	213.0	COG5400@1|root,COG5400@2|Bacteria,1RASG@1224|Proteobacteria,1S4ZN@1236|Gammaproteobacteria,1XAAG@135614|Xanthomonadales	135614|Xanthomonadales	S	Protein of unknown function (DUF1134)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1134
HKD2_k127_285562_7	941449.dsx2_0195	1.593e-31	128.0	COG0724@1|root,COG0724@2|Bacteria,1N6VR@1224|Proteobacteria,42V9Q@68525|delta/epsilon subdivisions,2WRRT@28221|Deltaproteobacteria,2MCID@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	PFAM RNP-1 like RNA-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	RRM_1
HKD2_k127_285562_8	485915.Dret_1753	4.454e-26	109.0	COG0724@1|root,COG0724@2|Bacteria,1N0P8@1224|Proteobacteria,43B6G@68525|delta/epsilon subdivisions,2WQ1E@28221|Deltaproteobacteria,2MH3Y@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	PFAM RNP-1 like RNA-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	RRM_1
HKD2_k127_285562_4	1148.1653338	7.973e-101	337.0	KOG1110@1|root,2Z8YY@2|Bacteria,1G31V@1117|Cyanobacteria	1117|Cyanobacteria	S	Protein of unknown function (DUF1838)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1838
HKD2_k127_285562_9	261292.Nit79A3_2588	1.732e-24	105.0	COG2119@1|root,COG2119@2|Bacteria	2|Bacteria	O	membrane	-	-	-	-	-	-	-	-	-	-	-	-	UPF0016
HKD2_k127_285562_3	221288.JH992901_gene5662	9.548e-146	479.0	COG1166@1|root,COG1166@2|Bacteria,1G1C4@1117|Cyanobacteria,1JKC5@1189|Stigonemataceae	1117|Cyanobacteria	E	Pyridoxal-dependent decarboxylase, pyridoxal binding domain	speA	-	4.1.1.19	ko:K01585	ko00330,ko01100,map00330,map01100	M00133	R00566	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N
HKD2_k127_2861086_6	1297865.APJD01000006_gene4543	2.208e-77	269.0	COG2020@1|root,COG2020@2|Bacteria,1MWU6@1224|Proteobacteria,2TU80@28211|Alphaproteobacteria,3JQR6@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	O	methyltransferase activity	-	-	2.1.1.334	ko:K21310	ko00920,map00920	-	R11546	RC02653	ko00000,ko00001,ko01000	-	-	-	NnrU,PEMT
HKD2_k127_2861086_2	187272.Mlg_1699	4.563e-177	567.0	COG0172@1|root,COG0172@2|Bacteria,1MUJF@1224|Proteobacteria,1RNAQ@1236|Gammaproteobacteria,1WX7U@135613|Chromatiales	135613|Chromatiales	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Seryl_tRNA_N,tRNA-synt_2b
HKD2_k127_2861086_1	1249627.D779_4100	6.198e-179	580.0	COG2256@1|root,COG2256@2|Bacteria,1MUVS@1224|Proteobacteria,1RPBY@1236|Gammaproteobacteria,1WVV4@135613|Chromatiales	135613|Chromatiales	L	AAA ATPase, central domain protein	-	-	-	ko:K07478	-	-	-	-	ko00000	-	-	-	AAA,AAA_assoc_2,MgsA_C,RuvB_N
HKD2_k127_2861086_8	1485544.JQKP01000002_gene1541	1.351e-47	179.0	COG2834@1|root,COG2834@2|Bacteria,1PXDV@1224|Proteobacteria,2VNNH@28216|Betaproteobacteria,44VR2@713636|Nitrosomonadales	28216|Betaproteobacteria	M	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)	lolA	-	-	ko:K03634	-	-	-	-	ko00000	-	-	-	LolA
HKD2_k127_2861086_0	713586.KB900536_gene612	1.683e-288	904.0	COG1674@1|root,COG1674@2|Bacteria,1MVPI@1224|Proteobacteria,1RM9A@1236|Gammaproteobacteria,1WWP6@135613|Chromatiales	135613|Chromatiales	D	DNA segregation ATPase FtsK SpoIIIE	-	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
HKD2_k127_2861086_3	768671.ThimaDRAFT_2432	6.823e-155	497.0	COG0492@1|root,COG0492@2|Bacteria,1MV15@1224|Proteobacteria,1RMEX@1236|Gammaproteobacteria,1WWPK@135613|Chromatiales	135613|Chromatiales	C	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
HKD2_k127_2861086_4	768671.ThimaDRAFT_2431	3.474e-108	362.0	COG3146@1|root,COG3146@2|Bacteria,1MU35@1224|Proteobacteria,1RNWI@1236|Gammaproteobacteria,1WXHA@135613|Chromatiales	135613|Chromatiales	S	Peptidogalycan biosysnthesis/recognition	-	-	-	ko:K09919	-	-	-	-	ko00000	-	-	-	FemAB_like
HKD2_k127_2861086_7	76114.ebA4891	1.276e-76	272.0	COG2360@1|root,COG2360@2|Bacteria,1R9W8@1224|Proteobacteria,2VIUV@28216|Betaproteobacteria,2KV37@206389|Rhodocyclales	206389|Rhodocyclales	O	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine	aat	-	2.3.2.6	ko:K00684	-	-	R03813,R11443,R11444	RC00055,RC00064	ko00000,ko01000	-	-	-	Leu_Phe_trans
HKD2_k127_2861086_10	1004785.AMBLS11_08380	4.672e-30	134.0	COG0361@1|root,COG0361@2|Bacteria,1MZFU@1224|Proteobacteria,1S8WZ@1236|Gammaproteobacteria,467YE@72275|Alteromonadaceae	1236|Gammaproteobacteria	J	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex	infA	GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K02518	-	-	-	-	ko00000,ko03012	-	-	-	eIF-1a
HKD2_k127_2861086_5	2340.JV46_14460	1.668e-83	281.0	COG0542@1|root,COG0542@2|Bacteria,1MV8B@1224|Proteobacteria,1RMH3@1236|Gammaproteobacteria,1J5A1@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	O	Belongs to the ClpA ClpB family	clpA	GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0043335,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564	-	ko:K03694	-	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
HKD2_k127_2868325_4	1157708.KB907452_gene3820	4.098e-37	140.0	COG0723@1|root,COG0723@2|Bacteria,1RAA2@1224|Proteobacteria,2VK46@28216|Betaproteobacteria,4AAIY@80864|Comamonadaceae	28216|Betaproteobacteria	C	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis	petA	-	1.10.2.2	ko:K00411	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002,ko01000	-	-	-	Rieske,UCR_Fe-S_N
HKD2_k127_2868325_0	1095769.CAHF01000003_gene986	6.594e-228	712.0	COG1290@1|root,COG1290@2|Bacteria,1MV97@1224|Proteobacteria,2VHP5@28216|Betaproteobacteria,4727H@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis	petB	-	-	ko:K00412	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002,ko03029	-	-	-	Cytochrom_B_C,Cytochrome_B
HKD2_k127_2868325_2	94624.Bpet0120	1.866e-72	271.0	COG2857@1|root,COG2857@2|Bacteria,1QFU2@1224|Proteobacteria,2VIR6@28216|Betaproteobacteria,3T1QQ@506|Alcaligenaceae	28216|Betaproteobacteria	P	Cytochrome C1	petC	-	-	ko:K00413	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002	-	-	-	Cytochrom_C1
HKD2_k127_2868325_1	426114.THI_2532	5.739e-115	373.0	COG0625@1|root,COG0625@2|Bacteria,1MXJD@1224|Proteobacteria,2VIAW@28216|Betaproteobacteria,1KKCU@119065|unclassified Burkholderiales	28216|Betaproteobacteria	O	Glutathione S-transferase	sspA	-	-	ko:K03599	-	-	-	-	ko00000,ko02000,ko03021	1.A.12.3.1	-	-	GST_C,GST_C_2,GST_N,GST_N_3
HKD2_k127_2868325_3	1157708.KB907452_gene3816	3.856e-47	174.0	COG2969@1|root,COG2969@2|Bacteria,1MZ2Q@1224|Proteobacteria,2VSGG@28216|Betaproteobacteria,4AE0F@80864|Comamonadaceae	28216|Betaproteobacteria	S	Stringent starvation protein B	sspB	-	-	ko:K03600	-	-	-	-	ko00000,ko03021	-	-	-	SspB
HKD2_k127_2868325_5	1097668.BYI23_B000910	1.242e-31	139.0	COG1309@1|root,COG1309@2|Bacteria,1R61M@1224|Proteobacteria,2VKHM@28216|Betaproteobacteria,1K6K5@119060|Burkholderiaceae	28216|Betaproteobacteria	K	TniQ	-	-	-	-	-	-	-	-	-	-	-	-	TniQ
HKD2_k127_2924593_2	1121875.KB907548_gene1637	2.961e-14	74.0	COG0664@1|root,COG0664@2|Bacteria,4NRPE@976|Bacteroidetes	976|Bacteroidetes	T	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
HKD2_k127_2924593_0	1168034.FH5T_19015	5.528e-113	392.0	COG0644@1|root,COG0644@2|Bacteria,4P040@976|Bacteroidetes	976|Bacteroidetes	C	oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2924593_1	331678.Cphamn1_1855	3.362e-60	233.0	COG0493@1|root,COG0493@2|Bacteria,1FDFY@1090|Chlorobi	1090|Chlorobi	C	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_20,Fer4_7,Fer4_9,Pyr_redox_2
HKD2_k127_2946724_1	204669.Acid345_1716	9.053e-17	87.0	COG1664@1|root,COG1664@2|Bacteria,3Y49V@57723|Acidobacteria,2JJ4E@204432|Acidobacteriia	57723|Acidobacteria	M	Polymer-forming cytoskeletal	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
HKD2_k127_2946724_2	247634.GPB2148_1942	1.961e-16	89.0	COG1664@1|root,COG1664@2|Bacteria,1ND4H@1224|Proteobacteria,1SF92@1236|Gammaproteobacteria,1JAKJ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	Polymer-forming cytoskeletal	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
HKD2_k127_2993308_15	1210045.ALNP01000032_gene2591	3.699e-14	72.0	COG3573@1|root,COG3573@2|Bacteria,2GIYM@201174|Actinobacteria	201174|Actinobacteria	S	Dehydrogenase	-	-	-	ko:K07077	-	-	-	-	ko00000	-	-	-	FAD_binding_2
HKD2_k127_2993308_11	1123368.AUIS01000001_gene1854	2.371e-23	107.0	COG3247@1|root,COG3247@2|Bacteria,1RH69@1224|Proteobacteria,1SAIB@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Short repeat of unknown function (DUF308)	-	-	-	-	-	-	-	-	-	-	-	-	DUF308
HKD2_k127_2993308_6	1028307.EAE_03190	2.267e-81	286.0	COG0220@1|root,COG0220@2|Bacteria,1MUWJ@1224|Proteobacteria,1RMFG@1236|Gammaproteobacteria,3X1KQ@547|Enterobacter	1236|Gammaproteobacteria	H	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA	trmB	GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008176,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0034708,GO:0036265,GO:0043170,GO:0043412,GO:0043414,GO:0043527,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0106004,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1990234	2.1.1.33	ko:K03439	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltransf_4
HKD2_k127_2993308_9	266117.Rxyl_0955	8.626e-47	176.0	COG2095@1|root,COG2095@2|Bacteria,2GMCM@201174|Actinobacteria	201174|Actinobacteria	U	UPF0056 membrane protein	-	-	-	ko:K05595	-	-	-	-	ko00000,ko02000	2.A.95.1	-	-	MarC
HKD2_k127_2993308_14	314278.NB231_10368	3.095e-19	93.0	2E600@1|root,330PC@2|Bacteria,1N9V9@1224|Proteobacteria,1SHAU@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2993308_12	1278073.MYSTI_05367	3.86e-23	115.0	COG2146@1|root,COG2146@2|Bacteria,1N72F@1224|Proteobacteria,43E2Z@68525|delta/epsilon subdivisions,2WZJE@28221|Deltaproteobacteria,2Z29H@29|Myxococcales	28221|Deltaproteobacteria	P	Rieske [2Fe-2S] domain	-	-	-	-	-	-	-	-	-	-	-	-	Rieske
HKD2_k127_2993308_0	1415779.JOMH01000001_gene589	3.873e-160	520.0	COG0477@1|root,COG2814@2|Bacteria,1MUZ8@1224|Proteobacteria,1T1NH@1236|Gammaproteobacteria,1X37G@135614|Xanthomonadales	135614|Xanthomonadales	EGP	Major facilitator superfamily	ampG	-	-	ko:K08218	ko01501,map01501	M00628	-	-	ko00000,ko00001,ko00002,ko02000	2.A.1.25	-	-	MFS_1
HKD2_k127_2993308_2	396588.Tgr7_0109	6.158e-129	427.0	COG0708@1|root,COG0708@2|Bacteria,1MVII@1224|Proteobacteria,1RN4H@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Exodeoxyribonuclease III	crc	-	3.1.11.2	ko:K01142	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exo_endo_phos
HKD2_k127_2993308_5	713586.KB900536_gene2325	6.436e-83	280.0	COG0461@1|root,COG0461@2|Bacteria,1MW6F@1224|Proteobacteria,1RQYG@1236|Gammaproteobacteria,1WWYM@135613|Chromatiales	135613|Chromatiales	F	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)	pyrE	-	2.4.2.10	ko:K00762	ko00240,ko01100,map00240,map01100	M00051	R01870	RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran
HKD2_k127_2993308_7	1278309.KB907104_gene962	6.041e-72	247.0	COG0756@1|root,COG0756@2|Bacteria,1RA7P@1224|Proteobacteria,1S233@1236|Gammaproteobacteria,1XJP4@135619|Oceanospirillales	135619|Oceanospirillales	F	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA	dut	-	3.6.1.23	ko:K01520	ko00240,ko00983,ko01100,map00240,map00983,map01100	M00053	R02100,R11896	RC00002	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	dUTPase
HKD2_k127_2993308_1	1234364.AMSF01000025_gene3546	7.71e-153	492.0	COG0452@1|root,COG0452@2|Bacteria,1MVQP@1224|Proteobacteria,1RMKQ@1236|Gammaproteobacteria,1X3EH@135614|Xanthomonadales	135614|Xanthomonadales	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	dfp	-	4.1.1.36,6.3.2.5	ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	DFP,Flavoprotein
HKD2_k127_2993308_3	396588.Tgr7_0319	6.352e-103	342.0	COG0266@1|root,COG0266@2|Bacteria,1MVM5@1224|Proteobacteria,1RP3J@1236|Gammaproteobacteria,1WX0V@135613|Chromatiales	135613|Chromatiales	L	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates	fpg	-	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
HKD2_k127_2993308_13	393595.ABO_0216	7.511e-20	89.0	COG0267@1|root,COG0267@2|Bacteria,1N6QV@1224|Proteobacteria,1SCEJ@1236|Gammaproteobacteria,1XMCR@135619|Oceanospirillales	135619|Oceanospirillales	J	there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc	rpmG	-	-	ko:K02913	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L33
HKD2_k127_2993308_10	1122603.ATVI01000006_gene124	1.071e-32	128.0	COG0227@1|root,COG0227@2|Bacteria,1MZ57@1224|Proteobacteria,1S8UG@1236|Gammaproteobacteria,1X7I6@135614|Xanthomonadales	135614|Xanthomonadales	J	Belongs to the bacterial ribosomal protein bL28 family	rpmB	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02902	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L28
HKD2_k127_2993308_4	1323663.AROI01000002_gene1221	2.38e-88	298.0	COG2003@1|root,COG2003@2|Bacteria,1MXZ5@1224|Proteobacteria,1RP86@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	Belongs to the UPF0758 family	radC	GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360	-	ko:K03630	-	-	-	-	ko00000	-	-	-	RadC
HKD2_k127_2993308_8	351746.Pput_4997	1.797e-60	214.0	COG0669@1|root,COG0669@2|Bacteria,1RD9F@1224|Proteobacteria,1S41J@1236|Gammaproteobacteria,1YV02@136845|Pseudomonas putida group	1236|Gammaproteobacteria	F	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate	coaD	GO:0003674,GO:0003824,GO:0004595,GO:0005488,GO:0005515,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.7.3	ko:K00954	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	iPC815.YPO0053,iSDY_1059.SDY_4064	CTP_transf_like
HKD2_k127_3033389_0	1379270.AUXF01000002_gene1507	8.189e-184	589.0	COG1680@1|root,COG1680@2|Bacteria,1ZUDN@142182|Gemmatimonadetes	142182|Gemmatimonadetes	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
HKD2_k127_3033389_1	1379698.RBG1_1C00001G1677	3.532e-97	330.0	COG3239@1|root,COG3239@2|Bacteria,2NNTZ@2323|unclassified Bacteria	2|Bacteria	I	Fatty acid desaturase	des	-	1.14.19.23,1.14.19.45	ko:K10255	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000,ko01004	-	-	-	FA_desaturase
HKD2_k127_3083536_0	401053.AciPR4_0365	1.037e-91	312.0	COG0165@1|root,COG0165@2|Bacteria,3Y7F3@57723|Acidobacteria,2JM7C@204432|Acidobacteriia	204432|Acidobacteriia	E	Argininosuccinate lyase C-terminal	-	-	4.3.2.1	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01086	RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ASL_C2,Lyase_1
HKD2_k127_3083536_1	344747.PM8797T_30312	9.432e-37	144.0	COG0589@1|root,COG0589@2|Bacteria,2J042@203682|Planctomycetes	203682|Planctomycetes	T	COG0589 Universal stress protein UspA and related nucleotide-binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD2_k127_3083536_2	379066.GAU_0987	2.899e-10	61.0	COG2091@1|root,COG2091@2|Bacteria,1ZUPU@142182|Gemmatimonadetes	142182|Gemmatimonadetes	H	Carbohydrate family 9 binding domain-like	-	-	-	-	-	-	-	-	-	-	-	-	CBM9_1
HKD2_k127_314488_5	102129.Lepto7375DRAFT_5281	2.912e-31	126.0	COG0662@1|root,COG0662@2|Bacteria,1GEZS@1117|Cyanobacteria	1117|Cyanobacteria	G	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HKD2_k127_314488_3	395493.BegalDRAFT_1700	3.163e-137	443.0	COG2513@1|root,COG2513@2|Bacteria,1N4VT@1224|Proteobacteria,1RMR5@1236|Gammaproteobacteria,46076@72273|Thiotrichales	72273|Thiotrichales	G	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate	prpB	-	4.1.3.30	ko:K03417	ko00640,map00640	-	R00409	RC00286,RC00287	ko00000,ko00001,ko01000	-	-	-	PEP_mutase
HKD2_k127_314488_2	267608.RSp0121	1.301e-215	672.0	COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,2VHJZ@28216|Betaproteobacteria,1K1TX@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Belongs to the citrate synthase family	prpC	-	2.3.3.5	ko:K01659	ko00640,map00640	-	R00931	RC00004,RC00406,RC02827	ko00000,ko00001,ko01000	-	-	-	Citrate_synt
HKD2_k127_314488_0	859657.RPSI07_mp0085	0.0	1561.0	COG1048@1|root,COG1048@2|Bacteria,1MU9T@1224|Proteobacteria,2VKDZ@28216|Betaproteobacteria,1K1NF@119060|Burkholderiaceae	28216|Betaproteobacteria	C	aconitate hydratase	acnD	-	4.2.1.117,4.2.1.3	ko:K01681,ko:K20455	ko00020,ko00630,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900,R11263	RC00497,RC00498,RC00618,RC01152	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
HKD2_k127_314488_1	1192124.LIG30_0043	4.983e-223	695.0	COG2828@1|root,COG2828@2|Bacteria,1MXVV@1224|Proteobacteria,2VJAW@28216|Betaproteobacteria,1K18H@119060|Burkholderiaceae	28216|Betaproteobacteria	S	AcnD-accessory protein PrpF	prpF	-	-	ko:K09788	ko00640,map00640	-	R11264	RC03405	ko00000,ko00001,ko01000	-	-	-	PrpF
HKD2_k127_314488_4	1163617.SCD_n01489	1.176e-92	308.0	COG2079@1|root,COG2079@2|Bacteria,1MUIG@1224|Proteobacteria,2VH7T@28216|Betaproteobacteria	28216|Betaproteobacteria	S	2-methylcitrate dehydratase	prpD	-	4.2.1.79	ko:K01720	ko00640,map00640	-	R04424	RC01152	ko00000,ko00001,ko01000	-	-	-	MmgE_PrpD
HKD2_k127_3214178_6	1380394.JADL01000010_gene4293	5.118e-66	229.0	COG0404@1|root,COG0665@1|root,COG0404@2|Bacteria,COG0665@2|Bacteria,1MUXJ@1224|Proteobacteria,2TRGS@28211|Alphaproteobacteria,2JR4V@204441|Rhodospirillales	204441|Rhodospirillales	E	FAD dependent oxidoreductase central domain	-	-	-	-	-	-	-	-	-	-	-	-	DAO,FAO_M,GCV_T,GCV_T_C
HKD2_k127_3214178_5	748247.AZKH_p0171	3.706e-123	404.0	COG4977@1|root,COG4977@2|Bacteria,1MUDK@1224|Proteobacteria,2VKZX@28216|Betaproteobacteria	28216|Betaproteobacteria	K	PFAM helix-turn-helix- domain containing protein, AraC type	-	-	-	ko:K21826	-	-	-	-	ko00000,ko03000	-	-	-	DJ-1_PfpI,HTH_18
HKD2_k127_3214178_0	748247.AZKH_p0176	0.0	1442.0	COG0404@1|root,COG0665@1|root,COG0404@2|Bacteria,COG0665@2|Bacteria,1MUXJ@1224|Proteobacteria,2VMMA@28216|Betaproteobacteria	28216|Betaproteobacteria	E	Belongs to the GcvT family	-	-	1.5.3.19,1.5.8.4	ko:K00315,ko:K19191	ko00260,ko00760,ko01100,ko01120,map00260,map00760,map01100,map01120	-	R01565,R10102	RC00060,RC00181,RC00557	ko00000,ko00001,ko01000	-	-	-	DAO,FAO_M,GCV_T,GCV_T_C
HKD2_k127_3214178_4	1090320.KB900605_gene2346	9.805e-229	719.0	COG0665@1|root,COG0665@2|Bacteria,1MVM6@1224|Proteobacteria,2TRM7@28211|Alphaproteobacteria,2K1JV@204457|Sphingomonadales	204457|Sphingomonadales	E	sarcosine oxidase, beta subunit	-	-	1.5.3.1	ko:K00303	ko00260,ko01100,map00260,map01100	-	R00610	RC00060,RC00557	ko00000,ko00001,ko01000	-	-	-	DAO
HKD2_k127_3214178_8	1125973.JNLC01000013_gene3915	1.263e-40	151.0	COG4311@1|root,COG4311@2|Bacteria,1MZC3@1224|Proteobacteria,2UC8C@28211|Alphaproteobacteria,3K143@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Sarcosine oxidase, delta subunit family	soxD	-	1.5.3.1	ko:K00304	ko00260,ko01100,map00260,map01100	-	R00610	RC00060,RC00557	ko00000,ko00001,ko01000	-	-	-	SoxD
HKD2_k127_3214178_1	1125973.JNLC01000013_gene3914	0.0	1343.0	COG0404@1|root,COG0446@1|root,COG0404@2|Bacteria,COG0446@2|Bacteria,1MVEK@1224|Proteobacteria,2TTD7@28211|Alphaproteobacteria,3JTMR@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Glycine cleavage T-protein C-terminal barrel domain	-	-	1.5.3.1	ko:K00302	ko00260,ko01100,map00260,map01100	-	R00610	RC00060,RC00557	ko00000,ko00001,ko01000	-	-	-	FAD_oxidored,Fer2_4,GCV_T,GCV_T_C,Pyr_redox_2
HKD2_k127_3214178_7	1125973.JNLC01000013_gene3913	1.105e-41	160.0	COG4583@1|root,COG4583@2|Bacteria,1N27A@1224|Proteobacteria,2UD7S@28211|Alphaproteobacteria,3K16T@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Sarcosine oxidase, gamma subunit family	soxG	-	1.5.3.1	ko:K00305	ko00260,ko01100,map00260,map01100	-	R00610	RC00060,RC00557	ko00000,ko00001,ko01000	-	-	-	SoxG
HKD2_k127_3214178_3	1122135.KB893166_gene2825	0.0	1068.0	COG0404@1|root,COG0665@1|root,COG0404@2|Bacteria,COG0665@2|Bacteria,1MUXJ@1224|Proteobacteria,2TRGS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Belongs to the GcvT family	dmgdh4	-	1.5.8.4	ko:K00315	ko00260,ko01100,map00260,map01100	-	R01565	RC00181	ko00000,ko00001,ko01000	-	-	-	DAO,FAO_M,GCV_T,GCV_T_C
HKD2_k127_3214178_2	1097668.BYI23_B001700	0.0	1161.0	COG0404@1|root,COG0665@1|root,COG0404@2|Bacteria,COG0665@2|Bacteria,1MUXJ@1224|Proteobacteria,2VMMA@28216|Betaproteobacteria,1K51F@119060|Burkholderiaceae	28216|Betaproteobacteria	E	Belongs to the GcvT family	-	-	1.5.3.19,1.5.8.4	ko:K00315,ko:K19191	ko00260,ko00760,ko01100,ko01120,map00260,map00760,map01100,map01120	-	R01565,R10102	RC00060,RC00181,RC00557	ko00000,ko00001,ko01000	-	-	-	DAO,FAO_M,GCV_T,GCV_T_C
HKD2_k127_3214365_2	910964.GEAM_1840	5.679e-26	108.0	COG3104@1|root,COG3104@2|Bacteria,1QXBE@1224|Proteobacteria,1RNVV@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	transporter	ydgR	-	-	ko:K03305,ko:K06218	-	-	-	-	ko00000,ko02048	2.A.17	-	-	MFS_1,PTR2
HKD2_k127_3214365_1	1168067.JAGP01000001_gene837	2.768e-66	238.0	COG2199@1|root,COG3706@2|Bacteria,1QVPY@1224|Proteobacteria,1T2GE@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	diguanylate cyclase	-	-	2.7.7.65	ko:K13069	-	-	R08057	-	ko00000,ko01000	-	-	-	CZB,GGDEF
HKD2_k127_3214365_0	1095769.CAHF01000022_gene305	8.434e-83	279.0	COG0500@1|root,COG2226@2|Bacteria,1NWX3@1224|Proteobacteria,2VH8H@28216|Betaproteobacteria	28216|Betaproteobacteria	Q	Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
HKD2_k127_3217093_8	1429851.X548_07790	9.104e-64	222.0	COG0531@1|root,COG0531@2|Bacteria,1MXNJ@1224|Proteobacteria,1RMKV@1236|Gammaproteobacteria,1X49X@135614|Xanthomonadales	135614|Xanthomonadales	E	amino acid	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
HKD2_k127_3217093_5	118161.KB235922_gene4205	1.052e-122	400.0	COG0037@1|root,COG0037@2|Bacteria,1G2S7@1117|Cyanobacteria,3VHP1@52604|Pleurocapsales	1117|Cyanobacteria	D	Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine cysteine desulfurase (IscS) system	-	-	-	ko:K14058	-	-	-	-	ko00000,ko03016	-	-	-	ATP_bind_3
HKD2_k127_3217093_4	693986.MOC_0904	2.516e-140	462.0	COG2317@1|root,COG2317@2|Bacteria,1MW7T@1224|Proteobacteria,2TSMY@28211|Alphaproteobacteria,1JS04@119045|Methylobacteriaceae	28211|Alphaproteobacteria	E	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues	-	-	3.4.17.19	ko:K01299	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M32
HKD2_k127_3217093_9	863365.XHC_1554	4.75e-57	214.0	COG3946@1|root,COG3946@2|Bacteria,1R7R5@1224|Proteobacteria,1S73H@1236|Gammaproteobacteria,1X4YR@135614|Xanthomonadales	135614|Xanthomonadales	U	Virulence protein	-	-	-	-	-	-	-	-	-	-	-	-	VirJ
HKD2_k127_3217093_0	1123392.AQWL01000005_gene3146	7.531e-245	782.0	COG0392@1|root,COG2898@1|root,COG0392@2|Bacteria,COG2898@2|Bacteria,1MXH9@1224|Proteobacteria,2VK9C@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Uncharacterised conserved protein (DUF2156)	-	-	2.3.2.3	ko:K07027,ko:K14205	ko01503,ko02020,ko05150,map01503,map02020,map05150	M00726	-	-	ko00000,ko00001,ko00002,ko01000,ko01504,ko02000	2.A.1.3.37,4.D.2	-	-	DUF2156,LPG_synthase_TM
HKD2_k127_3217093_3	754476.Q7A_2535	9.434e-147	474.0	COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,1RN6J@1236|Gammaproteobacteria,460E7@72273|Thiotrichales	72273|Thiotrichales	E	Pyridoxal-phosphate dependent enzyme	-	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HKD2_k127_3217093_10	644282.Deba_1115	2.047e-48	178.0	COG2030@1|root,COG2030@2|Bacteria,1RHPH@1224|Proteobacteria,42T27@68525|delta/epsilon subdivisions,2WPTI@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	PFAM MaoC like domain	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydratas
HKD2_k127_3217093_11	1442599.JAAN01000024_gene1967	7.277e-38	152.0	COG5394@1|root,COG5394@2|Bacteria,1RHRC@1224|Proteobacteria,1S2XX@1236|Gammaproteobacteria,1XC5X@135614|Xanthomonadales	135614|Xanthomonadales	S	synthesis repressor, PhaR	phaR	-	-	-	-	-	-	-	-	-	-	-	PHB_acc,PHB_acc_N
HKD2_k127_3217093_7	41431.PCC8801_2345	1.486e-78	273.0	COG0350@1|root,COG2207@1|root,COG0350@2|Bacteria,COG2207@2|Bacteria,1GHX6@1117|Cyanobacteria,3KJ06@43988|Cyanothece	1117|Cyanobacteria	H	Methylated-DNA- protein -cysteine S-methyltransferase DNA binding	-	-	2.1.1.63	ko:K00567,ko:K10778	-	-	-	-	ko00000,ko01000,ko03000,ko03400	-	-	-	DNA_binding_1
HKD2_k127_3217093_2	880073.Calab_3584	2.142e-147	483.0	COG0297@1|root,COG0297@2|Bacteria,2NQKG@2323|unclassified Bacteria	2|Bacteria	G	Synthesizes alpha-1,4-glucan chains using ADP-glucose	glgA	GO:0003674,GO:0003824,GO:0016740,GO:0016757	2.4.1.21	ko:K00703	ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026	M00565	R02421	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT5	-	Glyco_transf_5,Glycos_transf_1
HKD2_k127_3217093_14	983545.Glaag_3776	8.886e-22	102.0	COG5608@1|root,COG5608@2|Bacteria,1N6YX@1224|Proteobacteria,1T0IE@1236|Gammaproteobacteria,46DJ9@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Water Stress and Hypersensitive response	-	-	-	-	-	-	-	-	-	-	-	-	LEA_2
HKD2_k127_3217093_1	765914.ThisiDRAFT_1725	2.43e-186	591.0	COG0448@1|root,COG0448@2|Bacteria,1MVTC@1224|Proteobacteria,1RP04@1236|Gammaproteobacteria,1WW77@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans	glgC	-	2.7.7.27	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	M00565	R00948	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase
HKD2_k127_3217093_12	1121015.N789_02185	1.431e-36	142.0	COG1695@1|root,COG1695@2|Bacteria,1NJSY@1224|Proteobacteria,1SG6R@1236|Gammaproteobacteria,1X6UG@135614|Xanthomonadales	135614|Xanthomonadales	K	PadR family transcriptional regulator	-	-	-	ko:K10947	-	-	-	-	ko00000,ko03000	-	-	-	PadR
HKD2_k127_3217093_6	1384054.N790_07400	4.537e-95	323.0	COG4709@1|root,COG4709@2|Bacteria,1NX5K@1224|Proteobacteria,1SPS6@1236|Gammaproteobacteria,1X34I@135614|Xanthomonadales	135614|Xanthomonadales	S	Putative sensor	-	-	-	-	-	-	-	-	-	-	-	-	Sensor
HKD2_k127_3217093_13	1207063.P24_04699	4.549e-25	113.0	COG1430@1|root,COG1430@2|Bacteria,1MZBJ@1224|Proteobacteria,2UBSI@28211|Alphaproteobacteria,2JTN6@204441|Rhodospirillales	204441|Rhodospirillales	S	Uncharacterized ACR, COG1430	-	-	-	ko:K09005	-	-	-	-	ko00000	-	-	-	DUF192
HKD2_k127_3217093_15	1122603.ATVI01000001_gene1875	1.422e-14	84.0	COG2885@1|root,COG2885@2|Bacteria,1RKGT@1224|Proteobacteria,1S6ZQ@1236|Gammaproteobacteria,1X563@135614|Xanthomonadales	135614|Xanthomonadales	M	Belongs to the ompA family	mopB	-	-	ko:K03286	-	-	-	-	ko00000,ko02000	1.B.6	-	-	OMP_b-brl,OmpA,TSP_3
HKD2_k127_328769_1	1335757.SPICUR_01585	6.258e-279	865.0	COG0843@1|root,COG0843@2|Bacteria,1MU7S@1224|Proteobacteria,1RPC3@1236|Gammaproteobacteria,1WWX1@135613|Chromatiales	135613|Chromatiales	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	-	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
HKD2_k127_328769_10	1323663.AROI01000008_gene2527	2.277e-34	139.0	COG3175@1|root,COG3175@2|Bacteria,1RDTU@1224|Proteobacteria,1S5XA@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	oxidase, assembly	ctaG	-	-	ko:K02258	ko00190,ko01100,ko04714,map00190,map01100,map04714	M00154	-	-	ko00000,ko00001,ko00002,ko03029	3.D.4.8	-	-	CtaG_Cox11
HKD2_k127_328769_5	1384054.N790_13520	1.092e-124	415.0	COG1845@1|root,COG1845@2|Bacteria,1MUCK@1224|Proteobacteria,1RN9D@1236|Gammaproteobacteria,1X3ZT@135614|Xanthomonadales	135614|Xanthomonadales	C	Heme copper-type cytochrome quinol oxidase subunit 3	cox3	-	1.9.3.1	ko:K02276	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.4,3.D.4.6	-	-	COX3
HKD2_k127_328769_11	297246.lpp0475	1.913e-11	69.0	2EGIJ@1|root,33AAQ@2|Bacteria,1NH9B@1224|Proteobacteria,1SGKJ@1236|Gammaproteobacteria,1JFAY@118969|Legionellales	118969|Legionellales	S	Protein of unknown function (DUF2909)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2909
HKD2_k127_328769_8	1123261.AXDW01000009_gene73	1.388e-41	162.0	COG3346@1|root,COG3346@2|Bacteria,1MZUH@1224|Proteobacteria,1S8S0@1236|Gammaproteobacteria,1X6QG@135614|Xanthomonadales	135614|Xanthomonadales	S	SURF1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	SURF1
HKD2_k127_328769_9	713586.KB900536_gene1813	1.444e-37	153.0	COG1999@1|root,COG1999@2|Bacteria,1N6R6@1224|Proteobacteria,1SWXH@1236|Gammaproteobacteria,1X1CE@135613|Chromatiales	135613|Chromatiales	S	signal sequence binding	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_328769_7	713586.KB900536_gene1812	5.097e-100	338.0	COG1612@1|root,COG1612@2|Bacteria,1MVJ4@1224|Proteobacteria,1RQWB@1236|Gammaproteobacteria,1WZSA@135613|Chromatiales	135613|Chromatiales	O	cytochrome oxidase assembly	-	-	-	ko:K02259	ko00190,ko00860,ko01100,ko01110,ko02020,ko04714,map00190,map00860,map01100,map01110,map02020,map04714	M00154	R07412	RC00769	ko00000,ko00001,ko00002,ko03029	3.D.4.4	-	-	COX15-CtaA
HKD2_k127_328769_6	1198232.CYCME_0641	2.194e-112	370.0	COG0109@1|root,COG0109@2|Bacteria,1MW3S@1224|Proteobacteria,1RNHC@1236|Gammaproteobacteria,460H9@72273|Thiotrichales	72273|Thiotrichales	O	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group	cyoE	-	2.5.1.141	ko:K02257	ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714	M00154	R07411	RC01786	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029	-	-	-	UbiA
HKD2_k127_328769_13	1454004.AW11_02142	1.577e-08	66.0	COG5652@1|root,COG5652@2|Bacteria,1PJUW@1224|Proteobacteria,2VHEZ@28216|Betaproteobacteria,1KQT3@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	S	VanZ like family	-	-	-	-	-	-	-	-	-	-	-	-	VanZ
HKD2_k127_328769_2	666685.R2APBS1_2317	9.402e-215	682.0	COG4805@1|root,COG4805@2|Bacteria,1R5EP@1224|Proteobacteria,1RRS6@1236|Gammaproteobacteria,1X5GF@135614|Xanthomonadales	135614|Xanthomonadales	S	Bacterial protein of unknown function (DUF885)	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
HKD2_k127_328769_0	396588.Tgr7_0080	1.48e-294	921.0	COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,1RNJI@1236|Gammaproteobacteria,1WWI3@135613|Chromatiales	135613|Chromatiales	L	PFAM UvrD REP helicase	uvrD	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
HKD2_k127_328769_4	713586.KB900536_gene2224	6.483e-172	551.0	COG0569@1|root,COG0569@2|Bacteria,1MW8R@1224|Proteobacteria,1RNVQ@1236|Gammaproteobacteria,1WVX7@135613|Chromatiales	135613|Chromatiales	P	PFAM TrkA-N domain	trkA	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
HKD2_k127_328769_3	580332.Slit_2941	1.18e-196	625.0	COG0168@1|root,COG0168@2|Bacteria,1MUIJ@1224|Proteobacteria,2VH82@28216|Betaproteobacteria,44W7S@713636|Nitrosomonadales	28216|Betaproteobacteria	P	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA	-	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
HKD2_k127_328769_12	498211.CJA_0659	1.459e-10	64.0	COG0744@1|root,COG0744@2|Bacteria,1QTST@1224|Proteobacteria,1RNHV@1236|Gammaproteobacteria,1FGQE@10|Cellvibrio	1236|Gammaproteobacteria	M	Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits)	mrcB	-	2.4.1.129,3.4.16.4	ko:K05365	ko00550,map00550	-	R04519	RC00005,RC00049	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase,UB2H
HKD2_k127_328770_5	1336235.JAEG01000001_gene2620	1.364e-64	233.0	COG4221@1|root,COG4221@2|Bacteria,1RAKI@1224|Proteobacteria,2TUJT@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HKD2_k127_328770_0	215803.DB30_7423	8.504e-231	732.0	COG1164@1|root,COG1164@2|Bacteria,1MWYN@1224|Proteobacteria,437WG@68525|delta/epsilon subdivisions,2X364@28221|Deltaproteobacteria,2YUG4@29|Myxococcales	28221|Deltaproteobacteria	E	Angiotensin-converting enzyme	-	-	3.4.15.1	ko:K01283	ko04614,ko04924,ko05142,ko05410,map04614,map04924,map05142,map05410	-	-	-	ko00000,ko00001,ko01000,ko01002,ko04090,ko04147	-	-	-	Peptidase_M2
HKD2_k127_328770_2	745411.B3C1_06859	7.508e-189	617.0	COG3104@1|root,COG3104@2|Bacteria,1MW6W@1224|Proteobacteria,1RM8P@1236|Gammaproteobacteria,1J5UX@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	U	COG3104 Dipeptide tripeptide permease	-	-	-	ko:K03305	-	-	-	-	ko00000	2.A.17	-	-	PTR2
HKD2_k127_328770_3	392499.Swit_0533	4.416e-163	528.0	COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,2TTYC@28211|Alphaproteobacteria,2K0Q2@204457|Sphingomonadales	204457|Sphingomonadales	Q	COG1228 Imidazolonepropionase and related amidohydrolases	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
HKD2_k127_328770_4	768671.ThimaDRAFT_3082	1.725e-82	286.0	COG0805@1|root,COG0805@2|Bacteria,1MVAY@1224|Proteobacteria,1RPRN@1236|Gammaproteobacteria,1WVX9@135613|Chromatiales	135613|Chromatiales	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides	tatC	-	-	ko:K03118	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	TatC
HKD2_k127_328770_8	1380387.JADM01000002_gene2231	2.154e-11	70.0	COG1826@1|root,COG1826@2|Bacteria,1N73F@1224|Proteobacteria,1SD9K@1236|Gammaproteobacteria,1XM56@135619|Oceanospirillales	135619|Oceanospirillales	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation	tatB	-	-	ko:K03117	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
HKD2_k127_328770_9	1123517.JOMR01000001_gene3	4.075e-11	66.0	COG1826@1|root,COG1826@2|Bacteria,1N6S4@1224|Proteobacteria,1SCC7@1236|Gammaproteobacteria,461D2@72273|Thiotrichales	72273|Thiotrichales	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system	tatA	-	-	ko:K03116	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
HKD2_k127_328770_6	765911.Thivi_2072	9.131e-54	192.0	COG1490@1|root,COG1490@2|Bacteria,1RGTV@1224|Proteobacteria,1S61I@1236|Gammaproteobacteria,1WYB4@135613|Chromatiales	135613|Chromatiales	J	rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality	dtd	-	-	ko:K07560	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Tyr_Deacylase
HKD2_k127_328770_7	1232410.KI421426_gene1441	1.691e-17	90.0	COG3063@1|root,COG3063@2|Bacteria,1QZ5S@1224|Proteobacteria,42XK8@68525|delta/epsilon subdivisions,2WSKB@28221|Deltaproteobacteria,43V3K@69541|Desulfuromonadales	28221|Deltaproteobacteria	NU	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_328770_1	1215092.PA6_020_01170	3.065e-222	711.0	COG0744@1|root,COG0744@2|Bacteria,1QTST@1224|Proteobacteria,1RNHV@1236|Gammaproteobacteria,1YD67@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	M	Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits)	mrcB	-	2.4.1.129,3.4.16.4	ko:K05365	ko00550,map00550	-	R04519	RC00005,RC00049	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase,UB2H
HKD2_k127_3295585_3	627192.SLG_20170	5.783e-187	595.0	COG2303@1|root,COG2303@2|Bacteria,1MV19@1224|Proteobacteria,2TQKQ@28211|Alphaproteobacteria,2K0FF@204457|Sphingomonadales	204457|Sphingomonadales	E	Belongs to the GMC oxidoreductase family	-	-	-	-	-	-	-	-	-	-	-	-	GMC_oxred_C,GMC_oxred_N,Lycopene_cycl
HKD2_k127_3295585_7	627192.SLG_20070	1.252e-111	376.0	COG1680@1|root,COG1680@2|Bacteria,1MVPR@1224|Proteobacteria,2VFM0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
HKD2_k127_3295585_12	743720.Psefu_0094	3.705e-60	210.0	COG0599@1|root,COG0599@2|Bacteria,1RJU6@1224|Proteobacteria,1S6JH@1236|Gammaproteobacteria,1YVDV@136845|Pseudomonas putida group	1236|Gammaproteobacteria	S	PFAM Carboxymuconolactone decarboxylase	HA62_21275	-	4.1.1.44	ko:K01607	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	-	R03470	RC00938	ko00000,ko00001,ko01000	-	-	-	CMD
HKD2_k127_3295585_9	627192.SLG_20130	1.187e-92	326.0	COG2084@1|root,COG2084@2|Bacteria,1MWR4@1224|Proteobacteria,2U157@28211|Alphaproteobacteria,2KAYX@204457|Sphingomonadales	204457|Sphingomonadales	I	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_11,NAD_binding_2
HKD2_k127_3295585_8	627192.SLG_20140	2.334e-97	334.0	COG0491@1|root,COG0491@2|Bacteria,1MUT2@1224|Proteobacteria,2TRG9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	COG0491 Zn-dependent hydrolases, including glyoxylases	MA20_14090	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HKD2_k127_3295585_13	627192.SLG_20080	9.785e-56	204.0	COG1028@1|root,COG1028@2|Bacteria,1R4GG@1224|Proteobacteria,2TV1Y@28211|Alphaproteobacteria,2KCNM@204457|Sphingomonadales	204457|Sphingomonadales	IQ	KR domain	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HKD2_k127_3295585_2	1123261.AXDW01000021_gene846	4.652e-244	775.0	COG2010@1|root,COG4993@1|root,COG2010@2|Bacteria,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,1RN5D@1236|Gammaproteobacteria,1X37B@135614|Xanthomonadales	135614|Xanthomonadales	G	PQQ-like domain	-	-	1.1.5.5	ko:K22473	ko00010,map00010	-	R09479	RC00088	ko00000,ko00001,ko01000	-	-	-	Cytochrome_CBB3,PQQ,PQQ_2
HKD2_k127_3295585_15	279238.Saro_1865	1.477e-51	188.0	COG0346@1|root,COG0346@2|Bacteria,1MWHG@1224|Proteobacteria,2U1WR@28211|Alphaproteobacteria,2K70M@204457|Sphingomonadales	204457|Sphingomonadales	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase_4
HKD2_k127_3295585_0	76114.ebA5760	9.516e-295	918.0	COG0365@1|root,COG0365@2|Bacteria,1MUX7@1224|Proteobacteria,2VKAN@28216|Betaproteobacteria,2KY70@206389|Rhodocyclales	206389|Rhodocyclales	I	Acetyl-coenzyme A synthetase N-terminus	-	-	6.2.1.16	ko:K01907	ko00280,ko00650,map00280,map00650	-	R01357	RC00004,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding
HKD2_k127_3295585_1	1192759.AKIB01000026_gene2163	1.166e-257	825.0	COG2010@1|root,COG4993@1|root,COG2010@2|Bacteria,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,2TS2Q@28211|Alphaproteobacteria,2K18E@204457|Sphingomonadales	204457|Sphingomonadales	CG	Dehydrogenase	-	-	1.1.9.1	ko:K17760	-	-	-	-	ko00000,ko01000	-	-	-	Cytochrome_CBB3,PQQ,PQQ_2
HKD2_k127_3295585_14	633149.Bresu_2051	4.362e-54	202.0	COG2207@1|root,COG2207@2|Bacteria,1MXT9@1224|Proteobacteria,2U0UP@28211|Alphaproteobacteria,2KHXI@204458|Caulobacterales	204458|Caulobacterales	K	PFAM helix-turn-helix- domain containing protein AraC type	-	-	-	-	-	-	-	-	-	-	-	-	AraC_binding_2,HTH_18
HKD2_k127_3295585_6	1449076.JOOE01000002_gene762	9.26e-132	436.0	COG2271@1|root,COG2271@2|Bacteria,1P24P@1224|Proteobacteria,2URTW@28211|Alphaproteobacteria,2KECT@204457|Sphingomonadales	204457|Sphingomonadales	G	Sugar (and other) transporter	-	-	-	ko:K08195	-	-	-	-	ko00000,ko02000	2.A.1.15	-	-	MFS_1,MFS_4
HKD2_k127_3295585_10	1552758.NC00_10450	5.034e-72	249.0	COG2021@1|root,COG2021@2|Bacteria,1RDEH@1224|Proteobacteria,1T1N9@1236|Gammaproteobacteria,1XD4T@135614|Xanthomonadales	135614|Xanthomonadales	E	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_4,Abhydrolase_6
HKD2_k127_3295585_5	675635.Psed_3709	2.358e-135	445.0	COG0022@1|root,COG0022@2|Bacteria,2GKFE@201174|Actinobacteria,4DZDF@85010|Pseudonocardiales	201174|Actinobacteria	C	Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase component beta subunit	acoB	-	1.2.4.1	ko:K00162,ko:K21417	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
HKD2_k127_3295585_4	1394178.AWOO02000013_gene7849	6.937e-152	490.0	COG1071@1|root,COG1071@2|Bacteria,2IBRC@201174|Actinobacteria,4EJ8W@85012|Streptosporangiales	201174|Actinobacteria	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	-	-	1.2.4.1	ko:K00161,ko:K21416	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
HKD2_k127_3295585_11	243924.LT42_13110	5.235e-63	227.0	COG1082@1|root,COG1082@2|Bacteria	2|Bacteria	G	myo-inosose-2 dehydratase activity	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
HKD2_k127_3295585_16	1265313.HRUBRA_01701	2.841e-06	50.0	COG0508@1|root,COG0508@2|Bacteria,1MUGY@1224|Proteobacteria,1RPKE@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	2-oxoacid dehydrogenases acyltransferase (catalytic domain)	-	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
HKD2_k127_3358265_8	471854.Dfer_0246	2.194e-45	168.0	COG1446@1|root,COG1446@2|Bacteria,4NF1U@976|Bacteroidetes,47K5N@768503|Cytophagia	976|Bacteroidetes	E	PFAM peptidase T2 asparaginase 2	-	-	3.4.19.5	ko:K13051	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Asparaginase_2
HKD2_k127_3358265_3	472759.Nhal_3173	1.505e-184	591.0	COG2918@1|root,COG2918@2|Bacteria,1MW9B@1224|Proteobacteria,1RPNQ@1236|Gammaproteobacteria,1WWFZ@135613|Chromatiales	135613|Chromatiales	H	Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily	gshA	-	6.3.2.2	ko:K01919	ko00270,ko00480,ko01100,map00270,map00480,map01100	M00118	R00894,R10993	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	Glu_cys_ligase
HKD2_k127_3358265_12	1122603.ATVI01000008_gene2377	1.101e-11	72.0	2EKQ7@1|root,33EDZ@2|Bacteria,1NHK0@1224|Proteobacteria,1SAXC@1236|Gammaproteobacteria,1X7M9@135614|Xanthomonadales	135614|Xanthomonadales	S	Protein of unknown function (DUF2845)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2845
HKD2_k127_3358265_13	319224.Sputcn32_3411	5.752e-11	71.0	2AJIK@1|root,31A5D@2|Bacteria,1QFUH@1224|Proteobacteria,1TD4X@1236|Gammaproteobacteria,2QDXU@267890|Shewanellaceae	1236|Gammaproteobacteria	S	Protein of unknown function (DUF2845)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2845
HKD2_k127_3358265_4	740709.A10D4_04190	6.949e-134	447.0	COG4805@1|root,COG4805@2|Bacteria,1MUBX@1224|Proteobacteria,1RMT7@1236|Gammaproteobacteria,2QEZK@267893|Idiomarinaceae	1236|Gammaproteobacteria	S	Bacterial protein of unknown function (DUF885)	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
HKD2_k127_3358265_1	1384056.N787_03295	8.631e-210	669.0	COG4805@1|root,COG4805@2|Bacteria,1MUBX@1224|Proteobacteria,1RMT7@1236|Gammaproteobacteria,1X39Z@135614|Xanthomonadales	135614|Xanthomonadales	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
HKD2_k127_3358265_6	1380394.JADL01000009_gene3398	2.585e-70	246.0	COG0412@1|root,COG0412@2|Bacteria,1MW7S@1224|Proteobacteria,2TTPH@28211|Alphaproteobacteria,2JYIB@204441|Rhodospirillales	204441|Rhodospirillales	Q	Dienelactone hydrolase family	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
HKD2_k127_3358265_0	305700.B447_19309	5.071e-237	750.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2VHGR@28216|Betaproteobacteria,2KUI9@206389|Rhodocyclales	206389|Rhodocyclales	C	Belongs to the aldehyde dehydrogenase family	gabD	-	1.2.1.16,1.2.1.20,1.2.1.79	ko:K00135	ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120	M00027	R00713,R00714,R02401	RC00080	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
HKD2_k127_3358265_7	1207063.P24_08539	3.614e-52	203.0	COG0477@1|root,COG2814@2|Bacteria,1MW19@1224|Proteobacteria,2TRQD@28211|Alphaproteobacteria,2JPV2@204441|Rhodospirillales	204441|Rhodospirillales	EGP	Sugar (and other) transporter	-	-	-	ko:K07552	-	-	-	-	ko00000,ko02000	2.A.1.2	-	-	MFS_1
HKD2_k127_3358265_5	572477.Alvin_0409	2.61e-128	436.0	COG0276@1|root,COG0276@2|Bacteria,1MVR1@1224|Proteobacteria,1RMMS@1236|Gammaproteobacteria,1WWRK@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the ferrous insertion into protoporphyrin IX	hemH	-	4.99.1.1,4.99.1.9	ko:K01772	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R00310,R11329	RC01012	ko00000,ko00001,ko00002,ko01000	-	-	-	Ferrochelatase
HKD2_k127_3358265_15	1279009.ADICEAN_01751	3.382e-07	61.0	2DEGI@1|root,2ZMXA@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3358265_11	1123487.KB892857_gene2318	2.961e-30	129.0	COG2353@1|root,COG2353@2|Bacteria,1N3P9@1224|Proteobacteria,2VSMB@28216|Betaproteobacteria,2KZ87@206389|Rhodocyclales	206389|Rhodocyclales	S	YceI-like domain	-	-	-	-	-	-	-	-	-	-	-	-	YceI
HKD2_k127_3358265_9	713586.KB900536_gene2851	4.125e-41	161.0	COG3038@1|root,COG3038@2|Bacteria,1RBP8@1224|Proteobacteria,1S563@1236|Gammaproteobacteria,1WY6W@135613|Chromatiales	135613|Chromatiales	C	Cytochrome	-	-	-	ko:K12262	-	-	-	-	ko00000	-	-	-	Ni_hydr_CYTB
HKD2_k127_3358265_10	1123366.TH3_18679	1.545e-38	158.0	COG2353@1|root,COG2353@2|Bacteria,1RJFZ@1224|Proteobacteria,2UBXA@28211|Alphaproteobacteria,2JTIZ@204441|Rhodospirillales	204441|Rhodospirillales	S	YceI-like domain	-	-	-	-	-	-	-	-	-	-	-	-	YceI
HKD2_k127_3358265_2	991905.SL003B_3845	5.495e-201	636.0	COG0687@1|root,COG0687@2|Bacteria,1NKD7@1224|Proteobacteria,2TYST@28211|Alphaproteobacteria,4BPST@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	E	Bacterial extracellular solute-binding protein	ydcS	GO:0005575,GO:0005623,GO:0006810,GO:0008150,GO:0008152,GO:0009058,GO:0009290,GO:0009292,GO:0009294,GO:0009987,GO:0015931,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0042618,GO:0042619,GO:0044464,GO:0044764,GO:0050657,GO:0051027,GO:0051179,GO:0051234,GO:0051704,GO:0071702,GO:0071704,GO:0071705,GO:0098657,GO:1901440,GO:1901441,GO:1901576	-	ko:K02055	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	SBP_bac_8
HKD2_k127_3358265_14	439375.Oant_2789	1.313e-08	57.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2TQMJ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system	ydcT	-	-	ko:K02052	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	ABC_tran,TOBE_2
HKD2_k127_3371812_7	627192.SLG_06530	2.759e-20	95.0	COG0574@1|root,COG0574@2|Bacteria,1MU0R@1224|Proteobacteria,2TR38@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PPDK_N
HKD2_k127_3371812_0	627192.SLG_06540	1.022e-306	949.0	COG3848@1|root,COG3848@2|Bacteria,1MV5C@1224|Proteobacteria,2U2Y8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	PEP-utilising enzyme, mobile domain	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers
HKD2_k127_3371812_2	392499.Swit_3263	2.622e-212	690.0	COG1629@1|root,COG4774@1|root,COG1629@2|Bacteria,COG4774@2|Bacteria,1R8HM@1224|Proteobacteria,2U3RH@28211|Alphaproteobacteria,2KCYK@204457|Sphingomonadales	204457|Sphingomonadales	P	TonB dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
HKD2_k127_3371812_1	935840.JAEQ01000003_gene279	1.844e-217	686.0	COG0404@1|root,COG0404@2|Bacteria,1MWZS@1224|Proteobacteria,2TSVD@28211|Alphaproteobacteria,43JE4@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	Aminomethyltransferase folate-binding domain	-	-	2.1.1.341	ko:K15066	ko00627,ko01120,map00627,map01120	-	R09271,R10136	RC00113,RC00392	ko00000,ko00001,ko01000	-	-	-	GCV_T,GCV_T_C
HKD2_k127_3371812_4	675635.Psed_3708	2.26e-89	306.0	COG1071@1|root,COG1071@2|Bacteria,2HVS4@201174|Actinobacteria	201174|Actinobacteria	C	Dehydrogenase E1 component	-	-	1.2.4.1	ko:K00161	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
HKD2_k127_3371812_3	1121403.AUCV01000015_gene4679	1.684e-105	354.0	COG0022@1|root,COG0022@2|Bacteria,1R8KB@1224|Proteobacteria,42MBM@68525|delta/epsilon subdivisions,2WJKG@28221|Deltaproteobacteria,2MIRG@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Transketolase, pyrimidine binding domain	acoB	-	1.2.4.1	ko:K00162,ko:K21417	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
HKD2_k127_3371812_5	882082.SaccyDRAFT_2213	4.824e-62	229.0	COG0508@1|root,COG0508@2|Bacteria,2GN5J@201174|Actinobacteria,4E13H@85010|Pseudonocardiales	201174|Actinobacteria	C	acetyltransferase component of pyruvate dehydrogenase complex	-	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
HKD2_k127_3371812_6	243924.LT42_13110	8.262e-44	167.0	COG1082@1|root,COG1082@2|Bacteria	2|Bacteria	G	myo-inosose-2 dehydratase activity	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
HKD2_k127_33723_17	661367.LLO_2510	1.791e-17	81.0	COG0407@1|root,COG0407@2|Bacteria,1MUG1@1224|Proteobacteria,1RMDH@1236|Gammaproteobacteria,1JD3S@118969|Legionellales	118969|Legionellales	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	hemE	GO:0003674,GO:0003824,GO:0004853,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006536,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009064,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019353,GO:0019438,GO:0019752,GO:0033013,GO:0033014,GO:0033526,GO:0034641,GO:0042168,GO:0042440,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0046501,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
HKD2_k127_33723_10	1380394.JADL01000010_gene4126	2.472e-81	274.0	COG0221@1|root,COG0221@2|Bacteria,1RA2F@1224|Proteobacteria,2TQZM@28211|Alphaproteobacteria,2JSIR@204441|Rhodospirillales	204441|Rhodospirillales	C	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions	ppa	-	3.6.1.1	ko:K01507	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyrophosphatase
HKD2_k127_33723_13	999541.bgla_2g09980	1.323e-44	184.0	COG0454@1|root,COG0456@2|Bacteria,1NKFC@1224|Proteobacteria	1224|Proteobacteria	K	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_33723_3	305700.B447_01271	2.337e-238	749.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2VI0I@28216|Betaproteobacteria,2KUXQ@206389|Rhodocyclales	206389|Rhodocyclales	IQ	COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
HKD2_k127_33723_11	1121943.KB900004_gene2873	2.342e-66	237.0	COG2755@1|root,COG2755@2|Bacteria,1RCXZ@1224|Proteobacteria,1S3QU@1236|Gammaproteobacteria,1XJIV@135619|Oceanospirillales	135619|Oceanospirillales	E	COG2755 Lysophospholipase L1 and related esterases	tesA	-	3.1.1.5	ko:K10804	ko01040,map01040	-	-	-	ko00000,ko00001,ko01000,ko01004	-	-	-	Lipase_GDSL_2
HKD2_k127_33723_8	1121015.N789_12150	8.033e-89	299.0	COG4181@1|root,COG4181@2|Bacteria,1MXG9@1224|Proteobacteria,1RMG1@1236|Gammaproteobacteria,1X623@135614|Xanthomonadales	135614|Xanthomonadales	Q	ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD2_k127_33723_4	519989.ECTPHS_03592	1.645e-216	708.0	COG3127@1|root,COG3127@2|Bacteria,1MU9R@1224|Proteobacteria,1RM8Y@1236|Gammaproteobacteria,1WX8V@135613|Chromatiales	135613|Chromatiales	Q	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX
HKD2_k127_33723_9	452637.Oter_4554	1.231e-87	299.0	COG1043@1|root,COG1043@2|Bacteria,46V8M@74201|Verrucomicrobia,3K837@414999|Opitutae	414999|Opitutae	M	PFAM transferase hexapeptide repeat containing protein	-	-	2.3.1.129	ko:K00677	ko00540,ko01100,ko01503,map00540,map01100,map01503	M00060	R04567	RC00039,RC00055	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Acetyltransf_11,Hexapep
HKD2_k127_33723_15	522306.CAP2UW1_2233	1.487e-42	166.0	2AYXV@1|root,31R3M@2|Bacteria,1RHPG@1224|Proteobacteria,2VS4A@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_33723_7	1384056.N787_01430	4.241e-114	381.0	COG1752@1|root,COG1752@2|Bacteria,1R7RX@1224|Proteobacteria,1RRTH@1236|Gammaproteobacteria,1X4R5@135614|Xanthomonadales	135614|Xanthomonadales	S	Patatin-like phospholipase	-	-	-	-	-	-	-	-	-	-	-	-	Patatin
HKD2_k127_33723_16	1384054.N790_00750	1.323e-17	90.0	COG3937@1|root,COG3937@2|Bacteria,1N1EW@1224|Proteobacteria,1SDB2@1236|Gammaproteobacteria,1X717@135614|Xanthomonadales	135614|Xanthomonadales	S	Poly(hydroxyalcanoate) granule associated protein	-	-	-	-	-	-	-	-	-	-	-	-	Phasin
HKD2_k127_33723_6	1384054.N790_00925	2.258e-130	433.0	COG1020@1|root,COG1020@2|Bacteria,1N7HY@1224|Proteobacteria,1S1HS@1236|Gammaproteobacteria,1X48P@135614|Xanthomonadales	135614|Xanthomonadales	Q	Protein of unknown function (DUF1298)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1298,WES_acyltransf
HKD2_k127_33723_1	391615.ABSJ01000054_gene1381	9.995e-263	824.0	COG3320@1|root,COG4221@1|root,COG3320@2|Bacteria,COG4221@2|Bacteria,1QSHC@1224|Proteobacteria,1RQP8@1236|Gammaproteobacteria,1J4MV@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	Q	Short chain dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_4,adh_short
HKD2_k127_33723_12	1122603.ATVI01000006_gene804	1.593e-57	203.0	COG3791@1|root,COG3791@2|Bacteria,1RHWZ@1224|Proteobacteria,1S4HQ@1236|Gammaproteobacteria,1X72V@135614|Xanthomonadales	135614|Xanthomonadales	S	Glutathione-dependent formaldehyde-activating enzyme	-	-	-	-	-	-	-	-	-	-	-	-	GFA
HKD2_k127_33723_14	1211813.CAPH01000017_gene841	1.359e-44	177.0	COG1597@1|root,COG1597@2|Bacteria,4NGPY@976|Bacteroidetes,2FP27@200643|Bacteroidia,22U5U@171550|Rikenellaceae	976|Bacteroidetes	I	lipid kinase, YegS Rv2252 BmrU family	-	-	-	-	-	-	-	-	-	-	-	-	DAGK_cat
HKD2_k127_33723_5	1379270.AUXF01000003_gene3543	3.257e-148	477.0	COG1013@1|root,COG1013@2|Bacteria,1ZSWT@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
HKD2_k127_33723_2	394221.Mmar10_0351	5.092e-261	832.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,1NBSJ@1224|Proteobacteria,2TU21@28211|Alphaproteobacteria,43Z43@69657|Hyphomonadaceae	28211|Alphaproteobacteria	C	pyruvate flavodoxin ferredoxin oxidoreductase	MA20_01045	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR,POR_N
HKD2_k127_33723_0	1280944.HY17_08395	4.333e-285	885.0	COG0493@1|root,COG1143@1|root,COG0493@2|Bacteria,COG1143@2|Bacteria,1MU2H@1224|Proteobacteria,2TQK5@28211|Alphaproteobacteria,43ZFF@69657|Hyphomonadaceae	28211|Alphaproteobacteria	C	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	MA20_01050	-	1.17.1.10	ko:K15022	ko00680,ko00720,ko01120,ko01200,map00680,map00720,map01120,map01200	M00377	R00134	RC02796	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4_20,Fer4_7,NADH_4Fe-4S,Pyr_redox_2,Pyr_redox_3
HKD2_k127_339933_7	420662.Mpe_A3510	7.444e-123	409.0	28MAA@1|root,2ZAP0@2|Bacteria,1R5EZ@1224|Proteobacteria,2VNTE@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_339933_2	1123073.KB899241_gene1718	1.538e-165	532.0	COG0012@1|root,COG0012@2|Bacteria,1MVM4@1224|Proteobacteria,1RMBI@1236|Gammaproteobacteria,1X3B7@135614|Xanthomonadales	135614|Xanthomonadales	J	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner	ychF	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,YchF-GTPase_C
HKD2_k127_339933_12	519989.ECTPHS_02436	1.568e-65	230.0	COG0193@1|root,COG0193@2|Bacteria,1MX1P@1224|Proteobacteria,1RPK3@1236|Gammaproteobacteria,1WWEP@135613|Chromatiales	135613|Chromatiales	J	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis	pth	-	3.1.1.29	ko:K01056	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	Pept_tRNA_hydro
HKD2_k127_339933_14	1122603.ATVI01000005_gene2903	7.412e-57	206.0	COG1825@1|root,COG1825@2|Bacteria,1RDH0@1224|Proteobacteria,1S46A@1236|Gammaproteobacteria,1X34R@135614|Xanthomonadales	135614|Xanthomonadales	J	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance	ctc	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02897	ko03010,map03010	M00178	-	-	ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L25p,Ribosomal_TL5_C
HKD2_k127_339933_3	1046724.KB889908_gene927	3.087e-150	482.0	COG0462@1|root,COG0462@2|Bacteria,1MW21@1224|Proteobacteria,1RMUC@1236|Gammaproteobacteria,464JX@72275|Alteromonadaceae	1236|Gammaproteobacteria	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	prs	GO:0000287,GO:0003674,GO:0003824,GO:0004749,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006015,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016772,GO:0016778,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0042301,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046391,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	iAF1260.b1207,iAPECO1_1312.APECO1_323,iB21_1397.B21_01192,iBWG_1329.BWG_1032,iE2348C_1286.E2348C_1330,iEC042_1314.EC042_1264,iEC55989_1330.EC55989_1303,iECABU_c1320.ECABU_c14780,iECBD_1354.ECBD_2414,iECB_1328.ECB_01182,iECDH10B_1368.ECDH10B_1260,iECDH1ME8569_1439.ECDH1ME8569_1146,iECD_1391.ECD_01182,iECED1_1282.ECED1_1355,iECH74115_1262.ECH74115_1688,iECIAI1_1343.ECIAI1_1228,iECIAI39_1322.ECIAI39_1543,iECNA114_1301.ECNA114_1372,iECO103_1326.ECO103_1309,iECO111_1330.ECO111_1536,iECO26_1355.ECO26_1720,iECOK1_1307.ECOK1_1360,iECP_1309.ECP_1255,iECS88_1305.ECS88_1275,iECSE_1348.ECSE_1257,iECSF_1327.ECSF_1183,iECSP_1301.ECSP_1597,iECUMN_1333.ECUMN_1504,iECW_1372.ECW_m1293,iECs_1301.ECs1712,iEKO11_1354.EKO11_2647,iETEC_1333.ETEC_1311,iEcDH1_1363.EcDH1_2440,iEcE24377_1341.EcE24377A_1355,iEcHS_1320.EcHS_A1312,iEcSMS35_1347.EcSMS35_1935,iEcolC_1368.EcolC_2419,iG2583_1286.G2583_1478,iJO1366.b1207,iJR904.b1207,iLF82_1304.LF82_1744,iNRG857_1313.NRG857_06180,iSBO_1134.SBO_1860,iSDY_1059.SDY_1256,iSSON_1240.SSON_1971,iUMN146_1321.UM146_11025,iUMNK88_1353.UMNK88_1523,iUTI89_1310.UTI89_C1401,iWFL_1372.ECW_m1293,iY75_1357.Y75_RS06300,ic_1306.c1665	Pribosyl_synth,Pribosyltran_N
HKD2_k127_339933_8	314278.NB231_17283	1.814e-97	341.0	COG1947@1|root,COG1947@2|Bacteria,1MVU3@1224|Proteobacteria,1RP23@1236|Gammaproteobacteria,1WX6F@135613|Chromatiales	135613|Chromatiales	I	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol	ispE	-	2.7.1.148	ko:K00919	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05634	RC00002,RC01439	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
HKD2_k127_339933_15	1453503.AU05_23025	1.906e-22	106.0	COG3017@1|root,COG3017@2|Bacteria,1N02T@1224|Proteobacteria,1S91E@1236|Gammaproteobacteria,1YEHY@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	M	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein	lolB	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006807,GO:0008104,GO:0008150,GO:0008152,GO:0008289,GO:0009279,GO:0010876,GO:0016020,GO:0019538,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0033036,GO:0033218,GO:0034613,GO:0042157,GO:0042277,GO:0043170,GO:0044238,GO:0044462,GO:0044464,GO:0044872,GO:0044873,GO:0044874,GO:0051179,GO:0051641,GO:0051668,GO:0070727,GO:0071704,GO:0071723,GO:0071944,GO:0072657,GO:1901564	-	ko:K02494	-	-	-	-	ko00000	-	-	-	LolB
HKD2_k127_339933_11	391615.ABSJ01000045_gene2022	5.919e-69	255.0	COG0457@1|root,COG0457@2|Bacteria,1MYB8@1224|Proteobacteria,1RQIX@1236|Gammaproteobacteria,1J5FN@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	O	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_14,TPR_16,TPR_19,TPR_2,TPR_6,TPR_8
HKD2_k127_339933_6	1249627.D779_0933	2.844e-125	420.0	COG0373@1|root,COG0373@2|Bacteria,1MU41@1224|Proteobacteria,1RNQ8@1236|Gammaproteobacteria,1WX0A@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)	hemA	-	1.2.1.70	ko:K02492	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R04109	RC00055,RC00149	ko00000,ko00001,ko00002,ko01000	-	-	-	GlutR_N,GlutR_dimer,Shikimate_DH
HKD2_k127_339933_4	377629.TERTU_3844	1.385e-147	480.0	COG0216@1|root,COG0216@2|Bacteria,1MV28@1224|Proteobacteria,1RM7Q@1236|Gammaproteobacteria,2PMP1@256005|Alteromonadales genera incertae sedis	1236|Gammaproteobacteria	J	PCRF	prfA	GO:0003674,GO:0003676,GO:0003723,GO:0003747,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0016149,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K02835	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
HKD2_k127_339933_9	1118235.CAJH01000001_gene18	6.08e-78	271.0	COG2890@1|root,COG2890@2|Bacteria,1MXCQ@1224|Proteobacteria,1RNGK@1236|Gammaproteobacteria,1X4AP@135614|Xanthomonadales	135614|Xanthomonadales	J	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif	prmC	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0016740,GO:0016741,GO:0018364,GO:0019538,GO:0032259,GO:0036009,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0140096,GO:1901564	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS,Methyltransf_31
HKD2_k127_339933_13	187272.Mlg_0922	2.242e-63	221.0	COG0652@1|root,COG0652@2|Bacteria,1R9ZQ@1224|Proteobacteria,1S222@1236|Gammaproteobacteria,1WYD7@135613|Chromatiales	135613|Chromatiales	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	-	-	5.2.1.8	ko:K03767,ko:K03768	ko01503,ko04217,map01503,map04217	-	-	-	ko00000,ko00001,ko01000,ko03110,ko04147	-	-	-	Pro_isomerase
HKD2_k127_339933_10	1123253.AUBD01000005_gene6	4.673e-76	261.0	COG0744@1|root,COG0744@2|Bacteria,1RDAQ@1224|Proteobacteria,1RMGB@1236|Gammaproteobacteria,1X4AQ@135614|Xanthomonadales	135614|Xanthomonadales	M	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors	mtgA	-	2.4.1.129	ko:K03814	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly
HKD2_k127_339933_5	402881.Plav_0977	3.206e-147	485.0	COG2072@1|root,COG2072@2|Bacteria,1MUQH@1224|Proteobacteria,2TRG4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Flavoprotein involved in K transport	-	-	1.14.13.22	ko:K03379	ko00930,ko01120,ko01220,map00930,map01120,map01220	-	R02231,R06622	RC00662,RC01550	ko00000,ko00001,ko01000	-	-	-	FMO-like,Pyr_redox_3
HKD2_k127_339933_1	1242864.D187_000733	3.978e-238	747.0	COG2234@1|root,COG2234@2|Bacteria,1MV86@1224|Proteobacteria	1224|Proteobacteria	U	Peptidase m28	-	-	-	ko:K01269	-	-	-	-	ko00000,ko01000	-	-	-	PA,Peptidase_M28
HKD2_k127_339933_0	1286106.MPL1_11008	0.0	1010.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,1RMYD@1236|Gammaproteobacteria,4600V@72273|Thiotrichales	72273|Thiotrichales	E	Vitamin B12 dependent methionine synthase, activation	metH	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
HKD2_k127_3423741_9	1122604.JONR01000007_gene2935	8.02e-34	136.0	2B7EF@1|root,320I7@2|Bacteria,1NDV8@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	PSCyt1
HKD2_k127_3423741_0	1122604.JONR01000007_gene2934	6.515e-195	631.0	COG1404@1|root,COG3391@1|root,COG1404@2|Bacteria,COG3391@2|Bacteria,1MY07@1224|Proteobacteria	1224|Proteobacteria	O	COG3209 Rhs family protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3423741_7	886293.Sinac_3761	2.99e-41	170.0	COG1680@1|root,COG1680@2|Bacteria,2J0ZW@203682|Planctomycetes	203682|Planctomycetes	V	Beta-lactamase class C	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
HKD2_k127_3423741_1	279238.Saro_3187	5.772e-153	487.0	COG3186@1|root,COG3186@2|Bacteria,1MU29@1224|Proteobacteria,2TU1E@28211|Alphaproteobacteria,2K01F@204457|Sphingomonadales	204457|Sphingomonadales	E	Phenylalanine-4-hydroxylase	phhA	-	1.14.16.1	ko:K00500	ko00360,ko00400,ko00790,ko01100,ko01230,map00360,map00400,map00790,map01100,map01230	-	R01795,R07211	RC00490	ko00000,ko00001,ko01000	-	-	-	Biopterin_H
HKD2_k127_3423741_8	426355.Mrad2831_0936	2.444e-39	151.0	COG0251@1|root,COG0251@2|Bacteria,1MZ5K@1224|Proteobacteria,2U9DU@28211|Alphaproteobacteria,1JVSX@119045|Methylobacteriaceae	28211|Alphaproteobacteria	J	PFAM Endoribonuclease L-PSP	-	-	-	-	-	-	-	-	-	-	-	-	Ribonuc_L-PSP
HKD2_k127_3423741_3	266835.14026317	1.475e-112	375.0	COG0665@1|root,COG0665@2|Bacteria,1MY0G@1224|Proteobacteria,2TRM2@28211|Alphaproteobacteria,43IGQ@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	FAD dependent oxidoreductase	-	-	1.4.99.6	ko:K19746	ko00472,ko01100,map00472,map01100	-	R11018	RC00006	ko00000,ko00001,ko01000	-	-	-	DAO
HKD2_k127_3423741_2	420662.Mpe_A3687	1.856e-147	473.0	COG0715@1|root,COG0715@2|Bacteria,1MXA3@1224|Proteobacteria,2VI0Z@28216|Betaproteobacteria,1KKQQ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
HKD2_k127_3423741_4	420662.Mpe_A3414	1.087e-91	314.0	COG0600@1|root,COG0600@2|Bacteria,1MVAE@1224|Proteobacteria,2VI9J@28216|Betaproteobacteria,1KPEK@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
HKD2_k127_3423741_5	991905.SL003B_0792	4.206e-84	287.0	COG1116@1|root,COG1116@2|Bacteria,1MUIM@1224|Proteobacteria,2TRHM@28211|Alphaproteobacteria,4BPH4@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	P	ATPases associated with a variety of cellular activities	-	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
HKD2_k127_3423741_6	1116472.MGMO_84c00070	4.163e-64	229.0	COG1192@1|root,COG1192@2|Bacteria,1R62T@1224|Proteobacteria,1S58J@1236|Gammaproteobacteria,1XG72@135618|Methylococcales	135618|Methylococcales	D	Cellulose biosynthesis protein BcsQ	-	-	-	-	-	-	-	-	-	-	-	-	AAA_31
HKD2_k127_3423741_10	743719.PaelaDRAFT_0288	1.718e-32	132.0	COG2128@1|root,COG2128@2|Bacteria,1V66P@1239|Firmicutes,4HJTC@91061|Bacilli	91061|Bacilli	S	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3423741_11	1122603.ATVI01000013_gene1318	1.291e-23	104.0	COG0725@1|root,COG0725@2|Bacteria,1MVNA@1224|Proteobacteria,1RN71@1236|Gammaproteobacteria,1X6RU@135614|Xanthomonadales	135614|Xanthomonadales	P	ABC-type molybdate transport system periplasmic component	modA	GO:0003674,GO:0005488,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0015689,GO:0015698,GO:0030973,GO:0043167,GO:0043168,GO:0051179,GO:0051234,GO:1901359	-	ko:K02020	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.8	-	-	SBP_bac_11
HKD2_k127_378050_8	1300345.LF41_3080	6.732e-16	85.0	COG0385@1|root,COG0385@2|Bacteria,1N9IH@1224|Proteobacteria	1224|Proteobacteria	S	Bile acid	-	-	-	ko:K03453	-	-	-	-	ko00000	2.A.28	-	-	SBF
HKD2_k127_378050_3	335543.Sfum_2428	4.018e-129	444.0	COG4325@1|root,COG4325@2|Bacteria,1MXTM@1224|Proteobacteria,42NU4@68525|delta/epsilon subdivisions,2WKV0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Predicted membrane protein (DUF2254)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2254
HKD2_k127_378050_2	375286.mma_2403	9.757e-133	452.0	COG1752@1|root,COG4775@1|root,COG1752@2|Bacteria,COG4775@2|Bacteria,1MUM9@1224|Proteobacteria,2VJRI@28216|Betaproteobacteria,472FR@75682|Oxalobacteraceae	28216|Betaproteobacteria	M	Patatin-like phospholipase	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Bac_surface_Ag,POTRA,Patatin
HKD2_k127_378050_4	1210884.HG799469_gene14130	4.732e-86	291.0	COG1611@1|root,COG1611@2|Bacteria,2J21H@203682|Planctomycetes	203682|Planctomycetes	S	Possible lysine decarboxylase	-	-	-	-	-	-	-	-	-	-	-	-	Lysine_decarbox
HKD2_k127_378050_0	1042876.PPS_4079	3.726e-194	616.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,1RMBQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	belongs to the aldehyde dehydrogenase family	aldh1	-	1.2.1.3,1.2.1.83	ko:K00128,ko:K19700	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00760,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00760,map00903,map00981,map01100,map01110,map01120,map01130	M00135,M00811	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146,R10105	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
HKD2_k127_378050_6	565045.NOR51B_948	1.207e-30	132.0	COG3637@1|root,COG3637@2|Bacteria,1R0YP@1224|Proteobacteria,1T4RY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_378050_7	381666.H16_A2157	1.199e-22	105.0	2E9FY@1|root,333P7@2|Bacteria,1N8S6@1224|Proteobacteria,2VWAN@28216|Betaproteobacteria,1K7R1@119060|Burkholderiaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF1344
HKD2_k127_378050_1	1458357.BG58_13295	2.648e-186	598.0	COG4623@1|root,COG4623@2|Bacteria,1MWDS@1224|Proteobacteria,2VKSN@28216|Betaproteobacteria,1K51A@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_3,SLT
HKD2_k127_378050_5	1283300.ATXB01000001_gene397	9.883e-71	248.0	COG3900@1|root,COG3900@2|Bacteria,1RKQP@1224|Proteobacteria,1SB83@1236|Gammaproteobacteria,1XGK1@135618|Methylococcales	135618|Methylococcales	S	Predicted periplasmic protein (DUF2092)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2092
HKD2_k127_3839376_6	1211114.ALIP01000091_gene2899	2.479e-27	113.0	COG0635@1|root,COG0635@2|Bacteria,1MV1I@1224|Proteobacteria,1RN1Y@1236|Gammaproteobacteria,1X4K3@135614|Xanthomonadales	135614|Xanthomonadales	H	Belongs to the anaerobic coproporphyrinogen-III oxidase family	-	-	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
HKD2_k127_3839376_1	935863.AWZR01000003_gene2654	1.193e-73	263.0	COG3213@1|root,COG3213@2|Bacteria,1PJXJ@1224|Proteobacteria,1S4J4@1236|Gammaproteobacteria,1X3TN@135614|Xanthomonadales	135614|Xanthomonadales	P	protein involved in response to NO	-	-	-	ko:K07234	-	-	-	-	ko00000	-	-	-	NnrS
HKD2_k127_3839376_5	1122604.JONR01000008_gene2248	7.475e-31	127.0	COG3094@1|root,COG3094@2|Bacteria,1QB3J@1224|Proteobacteria,1T6ME@1236|Gammaproteobacteria,1X7S1@135614|Xanthomonadales	135614|Xanthomonadales	S	Invasion gene expression up-regulator, SirB	-	-	-	-	-	-	-	-	-	-	-	-	SirB
HKD2_k127_3839376_2	983545.Glaag_3793	9.299e-62	222.0	COG1024@1|root,COG1024@2|Bacteria,1MVQN@1224|Proteobacteria,1RPE2@1236|Gammaproteobacteria,465J5@72275|Alteromonadaceae	1236|Gammaproteobacteria	I	COG1024 Enoyl-CoA hydratase carnithine racemase	-	-	5.3.3.18	ko:K15866	ko00360,ko01120,map00360,map01120	-	R09837,R09839	RC00004,RC00326,RC02689,RC03003	ko00000,ko00001,ko01000	-	-	-	ECH_1
HKD2_k127_3839376_4	96561.Dole_1205	9.023e-35	144.0	COG3542@1|root,COG3542@2|Bacteria,1RHBE@1224|Proteobacteria,42T2P@68525|delta/epsilon subdivisions,2WPQ3@28221|Deltaproteobacteria,2MKI3@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Cupin superfamily (DUF985)	-	-	-	ko:K09705	-	-	-	-	ko00000	-	-	-	Cupin_5
HKD2_k127_3839376_3	631362.Thi970DRAFT_01296	4.418e-43	166.0	COG0664@1|root,COG0664@2|Bacteria,1R5P7@1224|Proteobacteria,1S6X3@1236|Gammaproteobacteria,1WWFD@135613|Chromatiales	135613|Chromatiales	K	PFAM Cyclic nucleotide-binding	-	-	-	ko:K21563	-	-	-	-	ko00000,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
HKD2_k127_3839376_0	1384054.N790_02840	8.401e-314	976.0	COG2010@1|root,COG2010@2|Bacteria,1N3PN@1224|Proteobacteria,1RNS0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Nitrite reductase	nirS	-	1.7.2.1,1.7.99.1	ko:K15864	ko00910,ko01120,map00910,map01120	M00529	R00143,R00783,R00785	RC00086,RC02797	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytochrom_D1,Cytochrome_CBB3
HKD2_k127_3852570_10	929556.Solca_3998	2.966e-36	146.0	COG3324@1|root,COG3324@2|Bacteria,4NZ00@976|Bacteroidetes	976|Bacteroidetes	E	translation initiation factor activity	-	-	-	ko:K06996	-	-	-	-	ko00000	-	-	-	Glyoxalase
HKD2_k127_3852570_1	1121015.N789_06390	1.392e-276	867.0	COG1770@1|root,COG1770@2|Bacteria,1MUED@1224|Proteobacteria,1RMSV@1236|Gammaproteobacteria,1X31I@135614|Xanthomonadales	135614|Xanthomonadales	E	peptidase	ptrB	-	3.4.21.83	ko:K01354	ko05142,ko05143,map05142,map05143	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S9,Peptidase_S9_N
HKD2_k127_3852570_5	1049564.TevJSym_as00320	3.472e-99	331.0	COG0501@1|root,COG0501@2|Bacteria,1MUNA@1224|Proteobacteria,1RMZ6@1236|Gammaproteobacteria,1J5TZ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	O	COG0501 Zn-dependent protease with chaperone function	Z012_09445	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
HKD2_k127_3852570_6	338969.Rfer_2632	8.553e-93	310.0	COG3917@1|root,COG3917@2|Bacteria,1RDNQ@1224|Proteobacteria,2VQJ1@28216|Betaproteobacteria,4AJTE@80864|Comamonadaceae	28216|Betaproteobacteria	Q	DSBA-like thioredoxin domain	-	-	5.99.1.4	ko:K14584	ko00626,ko01100,ko01120,ko01220,map00626,map01100,map01120,map01220	M00534	R05137	RC03084	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	DSBA
HKD2_k127_3852570_3	83406.HDN1F_27760	1.316e-131	436.0	COG1680@1|root,COG1680@2|Bacteria,1QD0J@1224|Proteobacteria,1RR1C@1236|Gammaproteobacteria,1J5C4@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	V	COG1680 Beta-lactamase class C and other penicillin binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
HKD2_k127_3852570_4	522306.CAP2UW1_2304	7.656e-109	356.0	COG0625@1|root,COG0625@2|Bacteria,1MUN3@1224|Proteobacteria,2VHCD@28216|Betaproteobacteria,1KQRA@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	O	Glutathione S-transferase, C-terminal domain	-	-	2.5.1.18	ko:K00799,ko:K11209	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C,GST_N
HKD2_k127_3852570_2	1121015.N789_02170	3.252e-190	603.0	COG1902@1|root,COG1902@2|Bacteria,1MVE0@1224|Proteobacteria,1RR6H@1236|Gammaproteobacteria,1X5MV@135614|Xanthomonadales	135614|Xanthomonadales	C	NADH:flavin oxidoreductase / NADH oxidase family	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_FMN
HKD2_k127_3852570_11	686340.Metal_3622	6.591e-17	93.0	2EAFX@1|root,334J9@2|Bacteria,1R3G6@1224|Proteobacteria,1TGY3@1236|Gammaproteobacteria,1XGX5@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3852570_0	1207075.PputUW4_02307	0.0	1082.0	COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,1RN01@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Exporters of the RND superfamily	-	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
HKD2_k127_3852570_8	1207075.PputUW4_02306	8.251e-88	302.0	COG4447@1|root,COG4447@2|Bacteria	2|Bacteria	S	cellulose binding	ycf48	-	-	-	-	-	-	-	-	-	-	-	PSII_BNR
HKD2_k127_3852570_7	1207075.PputUW4_02305	2.528e-90	299.0	28H52@1|root,2Z7HQ@2|Bacteria,1MXTF@1224|Proteobacteria,1RN8H@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function (DUF1329)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1329
HKD2_k127_3866600_1	477228.YO5_04317	6.282e-14	71.0	COG2010@1|root,COG2010@2|Bacteria,1N3PN@1224|Proteobacteria,1RNS0@1236|Gammaproteobacteria,1Z1V4@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	C	COG2010 Cytochrome c, mono- and diheme variants	nirS	GO:0005575,GO:0005623,GO:0042597,GO:0044464	1.7.2.1,1.7.99.1	ko:K15864	ko00910,ko01120,map00910,map01120	M00529	R00143,R00783,R00785	RC00086,RC02797	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytochrom_D1,Cytochrome_CBB3
HKD2_k127_3866600_0	522373.Smlt0795	1.114e-149	500.0	COG1629@1|root,COG4771@2|Bacteria,1MX42@1224|Proteobacteria,1RQ2K@1236|Gammaproteobacteria,1X35F@135614|Xanthomonadales	135614|Xanthomonadales	P	receptor	-	-	-	ko:K16087	-	-	-	-	ko00000,ko02000	1.B.14.2	-	-	Plug,TonB_dep_Rec
HKD2_k127_387802_1	1487953.JMKF01000074_gene3681	2.617e-40	162.0	COG0642@1|root,COG0745@1|root,COG2202@1|root,COG3829@1|root,COG0745@2|Bacteria,COG2202@2|Bacteria,COG2205@2|Bacteria,COG3829@2|Bacteria,1G09B@1117|Cyanobacteria,1H7M4@1150|Oscillatoriales	1117|Cyanobacteria	T	Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS,GAF,GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
HKD2_k127_387802_0	1122604.JONR01000004_gene814	1.689e-49	184.0	COG3791@1|root,COG3791@2|Bacteria,1RCYS@1224|Proteobacteria,1S3X0@1236|Gammaproteobacteria,1X6FP@135614|Xanthomonadales	135614|Xanthomonadales	S	Glutathione-dependent formaldehyde-activating enzyme	-	-	-	-	-	-	-	-	-	-	-	-	GFA
HKD2_k127_3897600_0	1147.D082_20570	1.439e-81	275.0	COG3588@1|root,COG3588@2|Bacteria,1GIGU@1117|Cyanobacteria,1H6CK@1142|Synechocystis	1117|Cyanobacteria	F	Fructose-bisphosphate aldolase class-I	-	-	4.1.2.13	ko:K01623	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000,ko03036,ko04131,ko04147	-	-	-	Glycolytic
HKD2_k127_3897600_2	42256.RradSPS_0172	2.654e-58	211.0	COG1216@1|root,COG1216@2|Bacteria,2IIII@201174|Actinobacteria	201174|Actinobacteria	S	Glycosyl transferase, family 2	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3897600_1	1056820.KB900638_gene108	2.84e-71	246.0	COG1028@1|root,COG1028@2|Bacteria,1RHYX@1224|Proteobacteria,1S0GN@1236|Gammaproteobacteria,2PNF0@256005|Alteromonadales genera incertae sedis	1236|Gammaproteobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HKD2_k127_3897600_3	1117943.SFHH103_02293	1.036e-33	134.0	COG3254@1|root,COG3254@2|Bacteria,1RIRS@1224|Proteobacteria,2UAT0@28211|Alphaproteobacteria,4BJKV@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Antibiotic biosynthesis monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	ABM
HKD2_k127_3897600_4	671143.DAMO_2421	1.625e-24	115.0	2C6B3@1|root,33P2S@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3898226_4	745310.G432_00475	4.923e-190	619.0	COG4773@1|root,COG4773@2|Bacteria,1QTXJ@1224|Proteobacteria,2TZ62@28211|Alphaproteobacteria,2K0KJ@204457|Sphingomonadales	204457|Sphingomonadales	P	TonB dependent receptor	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
HKD2_k127_3898226_2	1452718.JBOY01000055_gene1736	4.076e-230	726.0	COG0028@1|root,COG0028@2|Bacteria,1P76A@1224|Proteobacteria,1RP3S@1236|Gammaproteobacteria	1236|Gammaproteobacteria	EH	COG0028 Thiamine pyrophosphate-requiring enzymes acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
HKD2_k127_3898226_12	570952.ATVH01000013_gene3019	4.799e-68	246.0	COG3380@1|root,COG3380@2|Bacteria,1R5C0@1224|Proteobacteria,2U3PZ@28211|Alphaproteobacteria,2JT3U@204441|Rhodospirillales	204441|Rhodospirillales	S	Flavin containing amine oxidoreductase	-	-	-	ko:K06955	-	-	-	-	ko00000	-	-	-	Amino_oxidase,NAD_binding_8
HKD2_k127_3898226_15	1123392.AQWL01000005_gene3146	1.483e-44	174.0	COG0392@1|root,COG2898@1|root,COG0392@2|Bacteria,COG2898@2|Bacteria,1MXH9@1224|Proteobacteria,2VK9C@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Uncharacterised conserved protein (DUF2156)	-	-	2.3.2.3	ko:K07027,ko:K14205	ko01503,ko02020,ko05150,map01503,map02020,map05150	M00726	-	-	ko00000,ko00001,ko00002,ko01000,ko01504,ko02000	2.A.1.3.37,4.D.2	-	-	DUF2156,LPG_synthase_TM
HKD2_k127_3898226_21	640510.BC1001_0118	2.68e-18	90.0	2E69Z@1|root,330XW@2|Bacteria,1MZGG@1224|Proteobacteria,2VUXC@28216|Betaproteobacteria,1KI0S@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Specific class of high-redox-potential 4Fe-4S ferredoxins. Functions in anaerobic electron transport in most purple and in some other photosynthetic bacteria and in at least one genus (Paracoccus) of halophilic, denitrifying bacteria	-	-	-	-	-	-	-	-	-	-	-	-	HIPIP
HKD2_k127_3898226_0	1232410.KI421421_gene3797	0.0	1042.0	COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,42MEQ@68525|delta/epsilon subdivisions,2WIPF@28221|Deltaproteobacteria,43T5A@69541|Desulfuromonadales	28221|Deltaproteobacteria	G	Protein of unknown function (DUF3417)	glgP	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	DUF3417,Phosphorylase
HKD2_k127_3898226_17	237368.SCABRO_01642	3.183e-39	151.0	COG0071@1|root,COG0071@2|Bacteria,2J11X@203682|Planctomycetes	203682|Planctomycetes	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
HKD2_k127_3898226_14	572477.Alvin_1240	1.451e-59	213.0	COG0684@1|root,COG0684@2|Bacteria,1RH18@1224|Proteobacteria,1RS9U@1236|Gammaproteobacteria,1WY1P@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions	-	-	-	ko:K02553	-	-	-	-	ko00000,ko03019	-	-	-	RraA-like
HKD2_k127_3898226_19	713587.THITH_01520	1.647e-34	138.0	COG2924@1|root,COG2924@2|Bacteria,1MZ2V@1224|Proteobacteria,1S964@1236|Gammaproteobacteria,1WYU9@135613|Chromatiales	135613|Chromatiales	CO	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes	-	-	-	-	-	-	-	-	-	-	-	-	Iron_traffic
HKD2_k127_3898226_20	985665.HPL003_15905	3.972e-27	118.0	COG2363@1|root,COG2363@2|Bacteria,1VA79@1239|Firmicutes,4HKHG@91061|Bacilli,26Z1H@186822|Paenibacillaceae	91061|Bacilli	S	membrane	ywdK	-	-	-	-	-	-	-	-	-	-	-	DUF423
HKD2_k127_3898226_6	765913.ThidrDRAFT_1097	7.807e-116	386.0	COG1194@1|root,COG1194@2|Bacteria,1MUD4@1224|Proteobacteria,1RMBT@1236|Gammaproteobacteria,1WW1U@135613|Chromatiales	135613|Chromatiales	L	TIGRFAM A G-specific adenine glycosylase	-	-	-	ko:K03575	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD,NUDIX_4
HKD2_k127_3898226_11	1122603.ATVI01000005_gene3496	5.406e-88	314.0	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1S1MS@1236|Gammaproteobacteria,1X9IC@135614|Xanthomonadales	135614|Xanthomonadales	S	Adenylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3898226_16	1123261.AXDW01000007_gene2277	1.695e-41	170.0	COG3595@1|root,COG3595@2|Bacteria,1P19T@1224|Proteobacteria,1RRSR@1236|Gammaproteobacteria,1X62K@135614|Xanthomonadales	135614|Xanthomonadales	S	Putative adhesin	-	-	-	-	-	-	-	-	-	-	-	-	DUF4097
HKD2_k127_3898226_22	1384054.N790_09205	2.62e-08	63.0	2CKCT@1|root,32SC5@2|Bacteria,1N1BJ@1224|Proteobacteria,1T6U5@1236|Gammaproteobacteria,1X85I@135614|Xanthomonadales	135614|Xanthomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3898226_18	84531.JMTZ01000056_gene2533	2.087e-38	151.0	COG1595@1|root,COG1595@2|Bacteria,1RI1M@1224|Proteobacteria,1S780@1236|Gammaproteobacteria,1X678@135614|Xanthomonadales	135614|Xanthomonadales	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD2_k127_3898226_8	414684.RC1_1463	4.721e-101	338.0	COG1024@1|root,COG1024@2|Bacteria,1NDT7@1224|Proteobacteria,2U2R9@28211|Alphaproteobacteria,2JX5X@204441|Rhodospirillales	204441|Rhodospirillales	I	Enoyl-CoA hydratase/isomerase	-	-	4.2.1.17	ko:K01692	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
HKD2_k127_3898226_1	378806.STAUR_5205	2.289e-286	895.0	COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,42NY8@68525|delta/epsilon subdivisions,2WJNT@28221|Deltaproteobacteria,2YXXC@29|Myxococcales	28221|Deltaproteobacteria	E	Gamma-glutamyltranspeptidase	-	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
HKD2_k127_3898226_5	1255043.TVNIR_0100	2.87e-176	571.0	COG1232@1|root,COG1232@2|Bacteria,1R0KQ@1224|Proteobacteria,1S093@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX	-	-	1.3.3.15,1.3.3.4	ko:K00231	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03222,R04178	RC00885	ko00000,ko00001,ko00002,ko01000	-	-	-	Amino_oxidase
HKD2_k127_3898226_10	1397527.Q670_10260	2.092e-91	314.0	COG0604@1|root,COG0604@2|Bacteria,1QY04@1224|Proteobacteria,1RSP0@1236|Gammaproteobacteria,1XR3H@135619|Oceanospirillales	135619|Oceanospirillales	C	COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N,ADH_zinc_N_2
HKD2_k127_3898226_13	1163408.UU9_16426	7.533e-66	230.0	COG0705@1|root,COG0705@2|Bacteria,1RD88@1224|Proteobacteria,1S5NF@1236|Gammaproteobacteria,1X4YW@135614|Xanthomonadales	135614|Xanthomonadales	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
HKD2_k127_3898226_9	1121013.P873_05930	1.701e-100	331.0	COG0302@1|root,COG0302@2|Bacteria,1MY3N@1224|Proteobacteria,1RMQM@1236|Gammaproteobacteria,1X3YF@135614|Xanthomonadales	135614|Xanthomonadales	F	GTP cyclohydrolase	folE	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003933,GO:0003934,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006066,GO:0006725,GO:0006729,GO:0006732,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009108,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019238,GO:0019438,GO:0019751,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034311,GO:0034312,GO:0034641,GO:0035639,GO:0036094,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	3.5.4.16	ko:K01495	ko00790,ko01100,map00790,map01100	M00126,M00841,M00842,M00843	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	-	GTP_cyclohydroI
HKD2_k127_3898226_3	1123073.KB899241_gene2287	1.084e-223	698.0	COG0404@1|root,COG0404@2|Bacteria,1MV96@1224|Proteobacteria,1RN2A@1236|Gammaproteobacteria,1X7MH@135614|Xanthomonadales	135614|Xanthomonadales	E	Glycine cleavage T-protein C-terminal barrel domain	-	-	-	-	-	-	-	-	-	-	-	-	GCV_T,GCV_T_C
HKD2_k127_3898226_7	1123073.KB899241_gene2286	3.949e-109	376.0	COG1233@1|root,COG1233@2|Bacteria,1MV2R@1224|Proteobacteria,1RSGI@1236|Gammaproteobacteria,1X5MS@135614|Xanthomonadales	135614|Xanthomonadales	Q	Oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
HKD2_k127_3907835_32	1121859.KB890740_gene3836	2.778e-72	255.0	COG3119@1|root,COG3119@2|Bacteria,4NFRB@976|Bacteroidetes	976|Bacteroidetes	P	Arylsulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase,Sulfatase_C
HKD2_k127_3907835_35	269797.Mbar_A1532	2.89e-67	242.0	COG1926@1|root,arCOG06847@2157|Archaea,2XWRW@28890|Euryarchaeota,2NABG@224756|Methanomicrobia	224756|Methanomicrobia	S	Dienelactone hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	DLH
HKD2_k127_3907835_23	338969.Rfer_1232	3.812e-119	392.0	COG1234@1|root,COG1234@2|Bacteria,1PPRD@1224|Proteobacteria,2VNMY@28216|Betaproteobacteria,4AGEE@80864|Comamonadaceae	28216|Betaproteobacteria	S	Beta-lactamase superfamily domain	-	-	3.1.26.11	ko:K00784	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Lactamase_B_2
HKD2_k127_3907835_1	713587.THITH_03495	2.208e-273	852.0	COG0281@1|root,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,1RQ11@1236|Gammaproteobacteria,1WX9G@135613|Chromatiales	135613|Chromatiales	C	PFAM Malic enzyme, NAD binding domain	-	-	1.1.1.40	ko:K00029	ko00620,ko00710,ko01100,ko01120,ko01200,map00620,map00710,map01100,map01120,map01200	M00169,M00172	R00216	RC00105	ko00000,ko00001,ko00002,ko01000	-	-	-	Malic_M,malic
HKD2_k127_3907835_46	1384054.N790_07915	8.387e-45	167.0	COG0607@1|root,COG0607@2|Bacteria,1MZ87@1224|Proteobacteria,1S98V@1236|Gammaproteobacteria,1X8P0@135614|Xanthomonadales	135614|Xanthomonadales	P	Rhodanese domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
HKD2_k127_3907835_13	365044.Pnap_3840	2.083e-144	466.0	COG2355@1|root,COG2355@2|Bacteria,1MWEW@1224|Proteobacteria,2VP9R@28216|Betaproteobacteria,4AI23@80864|Comamonadaceae	28216|Betaproteobacteria	E	Membrane dipeptidase (Peptidase family M19)	-	-	3.4.13.19	ko:K01273	-	-	-	-	ko00000,ko00537,ko01000,ko01002,ko04147	-	-	-	Peptidase_M19
HKD2_k127_3907835_49	316055.RPE_0600	3.493e-37	158.0	COG1633@1|root,COG1633@2|Bacteria,1RJFW@1224|Proteobacteria,2U6JY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Rubrerythrin	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
HKD2_k127_3907835_22	85643.Tmz1t_2956	7.198e-123	408.0	COG1013@1|root,COG1013@2|Bacteria,1R5BF@1224|Proteobacteria,2VIQM@28216|Betaproteobacteria,2KY5Y@206389|Rhodocyclales	206389|Rhodocyclales	C	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
HKD2_k127_3907835_5	85643.Tmz1t_2955	5.298e-206	659.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,1NBSJ@1224|Proteobacteria,2VIEB@28216|Betaproteobacteria,2KY1I@206389|Rhodocyclales	206389|Rhodocyclales	C	Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR,POR_N
HKD2_k127_3907835_52	1123020.AUIE01000008_gene3661	4.377e-30	125.0	COG1846@1|root,COG1846@2|Bacteria,1MZY5@1224|Proteobacteria,1SERB@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
HKD2_k127_3907835_29	748247.AZKH_2921	1.704e-84	292.0	COG1566@1|root,COG1566@2|Bacteria,1MU7I@1224|Proteobacteria,2VHA2@28216|Betaproteobacteria,2KUUB@206389|Rhodocyclales	206389|Rhodocyclales	V	Biotin-lipoyl like	-	-	-	ko:K03543	-	M00701	-	-	ko00000,ko00002,ko02000	8.A.1.1	-	-	HlyD_3
HKD2_k127_3907835_16	1380391.JIAS01000011_gene5472	4.001e-141	465.0	COG0477@1|root,COG2814@2|Bacteria,1MU1I@1224|Proteobacteria,2TVXT@28211|Alphaproteobacteria,2JQ5F@204441|Rhodospirillales	204441|Rhodospirillales	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD2_k127_3907835_44	1122603.ATVI01000005_gene3859	7.962e-54	198.0	28M4Y@1|root,2ZAIT@2|Bacteria,1R7JR@1224|Proteobacteria,1S7QA@1236|Gammaproteobacteria,1X78B@135614|Xanthomonadales	135614|Xanthomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3907835_48	378806.STAUR_6009	2.259e-40	154.0	2E2SC@1|root,32XUP@2|Bacteria,1P2JD@1224|Proteobacteria,434IA@68525|delta/epsilon subdivisions,2WYVJ@28221|Deltaproteobacteria,2Z0QX@29|Myxococcales	28221|Deltaproteobacteria	S	Allene oxide cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Allene_ox_cyc
HKD2_k127_3907835_34	404589.Anae109_4324	7.086e-68	235.0	COG0204@1|root,COG0204@2|Bacteria,1RJMS@1224|Proteobacteria,42SG0@68525|delta/epsilon subdivisions,2WPEF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	Phosphate acyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Acyltransferase
HKD2_k127_3907835_12	383372.Rcas_2362	6.455e-145	477.0	COG5322@1|root,COG5322@2|Bacteria,2G7SR@200795|Chloroflexi,377XP@32061|Chloroflexia	32061|Chloroflexia	S	oxidoreductase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3907835_43	1479235.KK366039_gene3142	1.306e-54	199.0	COG3040@1|root,COG3040@2|Bacteria,1RDAI@1224|Proteobacteria,1S3PW@1236|Gammaproteobacteria,1XK1H@135619|Oceanospirillales	135619|Oceanospirillales	M	lipocalin	-	-	-	ko:K03098	-	-	-	-	ko00000,ko04147	-	-	-	Lipocalin_2
HKD2_k127_3907835_45	1463821.JOGR01000010_gene3715	3.751e-51	186.0	COG2132@1|root,COG2132@2|Bacteria,2I386@201174|Actinobacteria	201174|Actinobacteria	Q	Domain of unknown function (DUF4396)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4396
HKD2_k127_3907835_51	394.NGR_c22280	5.713e-34	136.0	COG0789@1|root,COG0789@2|Bacteria,1N0AZ@1224|Proteobacteria,2UD14@28211|Alphaproteobacteria,4BG6U@82115|Rhizobiaceae	28211|Alphaproteobacteria	K	helix_turn_helix, mercury resistance	merR	-	-	ko:K08365	-	-	-	-	ko00000,ko03000	-	-	-	MerR,MerR-DNA-bind,MerR_1
HKD2_k127_3907835_39	987059.RBXJA2T_16382	2.348e-63	223.0	COG0705@1|root,COG0705@2|Bacteria,1RB4A@1224|Proteobacteria,2VMPP@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Rhomboid family	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
HKD2_k127_3907835_11	382464.ABSI01000012_gene2146	2.677e-157	518.0	COG1593@1|root,COG1593@2|Bacteria	2|Bacteria	G	mannitol 2-dehydrogenase activity	-	-	-	ko:K11690	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.56.1	-	-	DctM,DctQ
HKD2_k127_3907835_30	395495.Lcho_3612	3.625e-78	273.0	COG1638@1|root,COG1638@2|Bacteria,1PMWE@1224|Proteobacteria,2VNJI@28216|Betaproteobacteria	28216|Betaproteobacteria	G	Bacterial extracellular solute-binding protein, family 7	-	-	-	-	-	-	-	-	-	-	-	-	DctP
HKD2_k127_3907835_31	335543.Sfum_2673	4.976e-76	269.0	COG5660@1|root,2Z7TM@2|Bacteria,1PMCV@1224|Proteobacteria,42Q81@68525|delta/epsilon subdivisions,2WIJ3@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	TRAP transporter T-component	-	-	-	-	-	-	-	-	-	-	-	-	TAtT
HKD2_k127_3907835_57	864051.BurJ1DRAFT_1493	9.714e-06	56.0	2E445@1|root,32Z0E@2|Bacteria,1N7FY@1224|Proteobacteria,2VWT7@28216|Betaproteobacteria,1KMAS@119065|unclassified Burkholderiales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3907835_42	287.DR97_5169	4.272e-61	225.0	COG0457@1|root,COG3271@1|root,COG0457@2|Bacteria,COG3271@2|Bacteria,1RA3D@1224|Proteobacteria,1S2EC@1236|Gammaproteobacteria,1YDEB@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	S	Peptidase_C39 like family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C39_2,TPR_16
HKD2_k127_3907835_4	1123261.AXDW01000002_gene1592	1.956e-223	702.0	COG0477@1|root,COG2814@2|Bacteria,1MU1I@1224|Proteobacteria,1RNTG@1236|Gammaproteobacteria,1X4BB@135614|Xanthomonadales	135614|Xanthomonadales	EGP	major facilitator superfamily	emrB	-	-	ko:K03446	-	M00701	-	-	ko00000,ko00002,ko02000	2.A.1.3	-	-	MFS_1
HKD2_k127_3907835_19	1122604.JONR01000022_gene626	1.374e-125	417.0	COG1566@1|root,COG1566@2|Bacteria,1MU7I@1224|Proteobacteria,1RMAD@1236|Gammaproteobacteria,1X3U7@135614|Xanthomonadales	135614|Xanthomonadales	V	Multidrug resistance efflux pump	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD,HlyD_3,HlyD_D23
HKD2_k127_3907835_17	1122604.JONR01000022_gene625	4.327e-131	441.0	COG1538@1|root,COG1538@2|Bacteria,1MUZZ@1224|Proteobacteria,1RQEP@1236|Gammaproteobacteria,1X3VF@135614|Xanthomonadales	135614|Xanthomonadales	M	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
HKD2_k127_3907835_53	1123261.AXDW01000002_gene1595	5.616e-30	132.0	COG1846@1|root,COG1846@2|Bacteria,1N7BV@1224|Proteobacteria,1S2AX@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	transcriptional regulator	marR	GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0042221,GO:0044212,GO:0045892,GO:0045934,GO:0046677,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051716,GO:0060255,GO:0065007,GO:0070887,GO:0071236,GO:0080090,GO:0097159,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141	-	ko:K03712	-	-	-	-	ko00000,ko03000	-	-	-	MarR,MarR_2
HKD2_k127_3907835_25	1254432.SCE1572_04735	1.465e-99	333.0	COG3791@1|root,COG3791@2|Bacteria,1N031@1224|Proteobacteria,42SVA@68525|delta/epsilon subdivisions,2WPFH@28221|Deltaproteobacteria,2Z1X4@29|Myxococcales	28221|Deltaproteobacteria	S	Glutathione-dependent formaldehyde-activating enzyme	-	-	-	-	-	-	-	-	-	-	-	-	GFA
HKD2_k127_3907835_50	640081.Dsui_2245	3.2e-34	135.0	COG2010@1|root,COG2010@2|Bacteria,1N1Z3@1224|Proteobacteria,2VU18@28216|Betaproteobacteria,2KWVD@206389|Rhodocyclales	206389|Rhodocyclales	C	Domain of unknown function (DUF1924)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1924
HKD2_k127_3907835_55	1123401.JHYQ01000013_gene689	1.079e-27	124.0	COG3658@1|root,COG3658@2|Bacteria,1N28F@1224|Proteobacteria,1S2S2@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	PFAM Di-haem cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	DHC
HKD2_k127_3907835_40	748247.AZKH_3477	1.068e-62	222.0	COG3658@1|root,COG3658@2|Bacteria,1RB03@1224|Proteobacteria,2VQQ7@28216|Betaproteobacteria,2KZTT@206389|Rhodocyclales	206389|Rhodocyclales	C	Prokaryotic cytochrome b561	-	-	-	-	-	-	-	-	-	-	-	-	Ni_hydr_CYTB
HKD2_k127_3907835_26	269482.Bcep1808_6298	4.233e-96	336.0	COG0642@1|root,COG0745@1|root,COG0642@2|Bacteria,COG0745@2|Bacteria,1QTSX@1224|Proteobacteria,2W1JF@28216|Betaproteobacteria,1K38S@119060|Burkholderiaceae	28216|Betaproteobacteria	T	histidine kinase HAMP region domain protein	-	-	2.7.13.3	ko:K07645	ko02020,ko02024,map02020,map02024	M00453	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	2CSK_N,HATPase_c,HisKA
HKD2_k127_3907835_18	686340.Metal_0669	3.236e-126	411.0	COG0583@1|root,COG0583@2|Bacteria,1MZTA@1224|Proteobacteria,1RN7R@1236|Gammaproteobacteria,1XF7G@135618|Methylococcales	135618|Methylococcales	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HKD2_k127_3907835_37	686340.Metal_0558	8.242e-65	229.0	COG1182@1|root,COG1182@2|Bacteria,1P59R@1224|Proteobacteria,1S337@1236|Gammaproteobacteria,1XG7T@135618|Methylococcales	135618|Methylococcales	C	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity	azoR	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_2
HKD2_k127_3907835_47	745411.B3C1_02850	2.18e-42	160.0	COG2259@1|root,COG2259@2|Bacteria,1MZVP@1224|Proteobacteria,1S8UI@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	membrane	yqjF	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K15977	-	-	-	-	ko00000	-	-	-	DoxX
HKD2_k127_3907835_21	1122604.JONR01000006_gene2711	2.407e-123	401.0	COG1741@1|root,COG1741@2|Bacteria,1MWIP@1224|Proteobacteria,1RNVM@1236|Gammaproteobacteria,1X33N@135614|Xanthomonadales	135614|Xanthomonadales	S	Belongs to the pirin family	-	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin,Pirin_C
HKD2_k127_3907835_0	322710.Avin_02480	0.0	1097.0	COG0392@1|root,COG0474@1|root,COG0392@2|Bacteria,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,1RMYC@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.2	ko:K01531,ko:K12955	-	-	-	-	ko00000,ko01000	3.A.3.24,3.A.3.4	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3,LPG_synthase_TM
HKD2_k127_3907835_54	748247.AZKH_1172	1.505e-29	121.0	2DNV8@1|root,32ZAX@2|Bacteria,1R3MW@1224|Proteobacteria,2VWAR@28216|Betaproteobacteria,2KWYT@206389|Rhodocyclales	206389|Rhodocyclales	S	HicA toxin of bacterial toxin-antitoxin,	-	-	-	-	-	-	-	-	-	-	-	-	HicA_toxin
HKD2_k127_3907835_27	1123257.AUFV01000002_gene2759	1.005e-95	332.0	COG1073@1|root,COG1073@2|Bacteria,1MUCD@1224|Proteobacteria,1RP4I@1236|Gammaproteobacteria,1X63I@135614|Xanthomonadales	135614|Xanthomonadales	S	X-Pro dipeptidyl-peptidase (S15 family)	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4
HKD2_k127_3907835_41	1235457.C404_00540	1.163e-62	227.0	COG0583@1|root,COG0583@2|Bacteria,1MV06@1224|Proteobacteria,2VHGD@28216|Betaproteobacteria,1K083@119060|Burkholderiaceae	28216|Betaproteobacteria	K	Transcriptional regulator	-	-	-	ko:K18900	-	M00698	-	-	ko00000,ko00002,ko01504,ko03000	-	-	-	HTH_1,LysR_substrate
HKD2_k127_3907835_8	1040986.ATYO01000002_gene3904	1.147e-176	567.0	COG0076@1|root,COG0076@2|Bacteria,1MWUX@1224|Proteobacteria,2TTUK@28211|Alphaproteobacteria,43IWV@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	PFAM Pyridoxal-dependent decarboxylase	-	-	-	-	-	-	-	-	-	-	-	-	Pyridoxal_deC
HKD2_k127_3907835_14	926560.KE387023_gene2306	4.147e-144	468.0	COG0520@1|root,COG0520@2|Bacteria	2|Bacteria	E	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine	cefD	-	5.1.1.17	ko:K04127,ko:K11325,ko:K21174	ko00311,ko01059,ko01100,ko01130,map00311,map01059,map01100,map01130	M00673,M00825	R04147	RC00302	ko00000,ko00001,ko00002,ko01000	-	-	-	Aminotran_5
HKD2_k127_3907835_15	1095769.CAHF01000023_gene442	1.437e-142	471.0	COG3246@1|root,COG3246@2|Bacteria,1MZTP@1224|Proteobacteria,2VHPB@28216|Betaproteobacteria	28216|Betaproteobacteria	S	beta-keto acid cleavage enzyme	-	-	-	-	-	-	-	-	-	-	-	-	BKACE
HKD2_k127_3907835_3	342113.DM82_6353	1.463e-245	779.0	COG4770@1|root,COG4770@2|Bacteria,1P6RE@1224|Proteobacteria,2VJHH@28216|Betaproteobacteria,1K5NC@119060|Burkholderiaceae	28216|Betaproteobacteria	I	Biotin carboxylase C-terminal domain	-	-	6.4.1.4,6.4.1.5	ko:K01968,ko:K13777	ko00280,ko00281,ko01100,map00280,map00281,map01100	M00036	R03494,R04138	RC00367,RC00942	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2
HKD2_k127_3907835_33	342113.DM82_6352	7.083e-70	246.0	COG1024@1|root,COG1024@2|Bacteria,1MVEC@1224|Proteobacteria,2VKEV@28216|Betaproteobacteria,1KDT1@119060|Burkholderiaceae	28216|Betaproteobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	4.2.1.57	ko:K13779	ko00281,map00281	-	R03493	RC00941	ko00000,ko00001,ko01000	-	-	-	ECH_1
HKD2_k127_3907835_6	272560.BPSS2032	5.775e-194	610.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2VJ5I@28216|Betaproteobacteria,1K6EI@119060|Burkholderiaceae	28216|Betaproteobacteria	C	acyl-CoA dehydrogenase	-	-	-	ko:K11731	ko00281,map00281	-	R08089	RC01893	ko00000,ko00001,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HKD2_k127_3907835_2	342113.DM82_6350	3.411e-253	805.0	COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,2VIYY@28216|Betaproteobacteria,1K4B0@119060|Burkholderiaceae	28216|Betaproteobacteria	I	Carboxyl transferase domain	-	-	6.4.1.5	ko:K13778	ko00281,map00281	-	R03494	RC00367,RC00942	ko00000,ko00001,ko01000	-	-	-	Carboxyl_trans
HKD2_k127_3907835_20	342113.DM82_6349	8.961e-125	406.0	COG1028@1|root,COG1028@2|Bacteria,1PFUB@1224|Proteobacteria,2VK16@28216|Betaproteobacteria,1K64U@119060|Burkholderiaceae	28216|Betaproteobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	ko:K13774	ko00281,map00281	-	R08087,R08096,R10125,R10126	RC00080,RC00087	ko00000,ko00001	-	-	-	adh_short_C2
HKD2_k127_3907835_9	342113.DM82_6347	1.289e-165	529.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2VJ7Q@28216|Betaproteobacteria,1KGMD@119060|Burkholderiaceae	28216|Betaproteobacteria	C	acyl-CoA dehydrogenase	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HKD2_k127_3907835_38	1434929.X946_725	1.255e-64	228.0	COG1309@1|root,COG1309@2|Bacteria,1RGJ3@1224|Proteobacteria,2VHGC@28216|Betaproteobacteria,1K5C8@119060|Burkholderiaceae	28216|Betaproteobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_4,TetR_N
HKD2_k127_3907835_28	1218075.BAYA01000031_gene5987	2.34e-87	293.0	COG0745@1|root,COG0745@2|Bacteria,1N0YI@1224|Proteobacteria,2VHIS@28216|Betaproteobacteria,1K3WC@119060|Burkholderiaceae	28216|Betaproteobacteria	T	Transcriptional regulator	-	-	-	ko:K07666	ko02020,ko02024,map02020,map02024	M00453	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
HKD2_k127_3907835_24	1348657.M622_02615	2.905e-110	381.0	COG0642@1|root,COG0642@2|Bacteria,1QTSX@1224|Proteobacteria,2W1JF@28216|Betaproteobacteria,2KW6A@206389|Rhodocyclales	206389|Rhodocyclales	T	His Kinase A (phosphoacceptor) domain	-	-	2.7.13.3	ko:K02484	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA
HKD2_k127_3907835_10	1304883.KI912532_gene1357	3.207e-165	535.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2VI4Q@28216|Betaproteobacteria,2KVHE@206389|Rhodocyclales	206389|Rhodocyclales	O	Belongs to the peptidase S1C family	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
HKD2_k127_3907835_7	1122604.JONR01000001_gene1905	1.293e-191	617.0	COG4805@1|root,COG4805@2|Bacteria,1PIM6@1224|Proteobacteria,1RRW7@1236|Gammaproteobacteria,1X3BX@135614|Xanthomonadales	135614|Xanthomonadales	S	Bacterial protein of unknown function (DUF885)	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
HKD2_k127_3907835_36	1348657.M622_13695	1.216e-65	238.0	COG3203@1|root,COG3203@2|Bacteria,1MXEB@1224|Proteobacteria,2VPRW@28216|Betaproteobacteria	28216|Betaproteobacteria	M	Protein of unknown function (DUF1302)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1302
HKD2_k127_3929828_1	196490.AUEZ01000004_gene3888	1.487e-28	124.0	COG2801@1|root,COG2801@2|Bacteria,1N207@1224|Proteobacteria,2UEQQ@28211|Alphaproteobacteria,3JWDD@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_32,rve,rve_3
HKD2_k127_3929828_2	1121937.AUHJ01000005_gene2146	0.0001812	47.0	COG2801@1|root,COG2801@2|Bacteria,1N207@1224|Proteobacteria,1S1FB@1236|Gammaproteobacteria,46AN4@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	COG2801 Transposase and inactivated derivatives	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_28,HTH_32,LZ_Tnp_IS481,rve,rve_3
HKD2_k127_3929828_0	864051.BurJ1DRAFT_2047	1.468e-161	535.0	COG1404@1|root,COG1404@2|Bacteria,1MU3S@1224|Proteobacteria,2VWI8@28216|Betaproteobacteria	28216|Betaproteobacteria	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
HKD2_k127_3933675_0	32057.KB217483_gene9032	1.625e-29	136.0	COG0457@1|root,COG4995@1|root,COG0457@2|Bacteria,COG4995@2|Bacteria,1G135@1117|Cyanobacteria,1HIJM@1161|Nostocales	1117|Cyanobacteria	S	SPTR Tetratricopeptide TPR_2 repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	CHAT,TPR_12,TPR_7
HKD2_k127_3933675_2	414684.RC1_3903	0.0005137	51.0	COG1595@1|root,COG1595@2|Bacteria,1MX7T@1224|Proteobacteria,2U5A1@28211|Alphaproteobacteria,2JTCZ@204441|Rhodospirillales	204441|Rhodospirillales	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD2_k127_3933675_1	208444.JNYY01000001_gene4756	0.0002045	45.0	COG4319@1|root,COG4319@2|Bacteria,2H1H4@201174|Actinobacteria,4EDE3@85010|Pseudonocardiales	201174|Actinobacteria	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_3
HKD2_k127_3954282_7	158500.BV97_01170	1.09e-47	181.0	COG0654@1|root,COG0654@2|Bacteria,1MUN4@1224|Proteobacteria,2TQT8@28211|Alphaproteobacteria,2K23S@204457|Sphingomonadales	204457|Sphingomonadales	CH	FAD binding domain	pcpB	-	1.14.13.127,1.14.13.50	ko:K03391,ko:K05712	ko00360,ko00361,ko00364,ko01100,ko01120,ko01220,map00360,map00361,map00364,map01100,map01120,map01220	M00545	R03982,R06786,R06787,R07779	RC00236,RC01932	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_3
HKD2_k127_3954282_2	765910.MARPU_15110	7.992e-137	451.0	COG0617@1|root,COG0617@2|Bacteria,1MVCS@1224|Proteobacteria,1RMBG@1236|Gammaproteobacteria,1WWHC@135613|Chromatiales	135613|Chromatiales	J	Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control	pcnB	-	2.7.7.19	ko:K00970	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PolyA_pol,PolyA_pol_RNAbd,PolyA_pol_arg_C
HKD2_k127_3954282_8	1335757.SPICUR_02740	5.238e-39	156.0	COG0801@1|root,COG0801@2|Bacteria,1MZH8@1224|Proteobacteria,1S63J@1236|Gammaproteobacteria,1WYQM@135613|Chromatiales	135613|Chromatiales	H	PFAM 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK	-	-	2.7.6.3	ko:K00950	ko00790,ko01100,map00790,map01100	M00126,M00841	R03503	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	HPPK
HKD2_k127_3954282_6	396588.Tgr7_0880	6.293e-74	259.0	COG1428@1|root,COG1428@2|Bacteria,1RC50@1224|Proteobacteria,1RRXT@1236|Gammaproteobacteria,1X2ET@135613|Chromatiales	135613|Chromatiales	F	Deoxynucleoside kinase	-	-	-	-	-	-	-	-	-	-	-	-	dNK
HKD2_k127_3954282_4	1415780.JPOG01000001_gene1836	1.043e-99	333.0	COG0413@1|root,COG0413@2|Bacteria,1MU3B@1224|Proteobacteria,1RM8D@1236|Gammaproteobacteria,1X3R8@135614|Xanthomonadales	135614|Xanthomonadales	H	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate	-	-	-	-	-	-	-	-	-	-	-	-	Pantoate_transf
HKD2_k127_3954282_5	1211579.PP4_46790	1.087e-90	307.0	COG0414@1|root,COG0414@2|Bacteria,1MV1S@1224|Proteobacteria,1RMEG@1236|Gammaproteobacteria,1YW2T@136845|Pseudomonas putida group	1236|Gammaproteobacteria	H	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate	panC	GO:0003674,GO:0003824,GO:0004592,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006573,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0042364,GO:0042398,GO:0042802,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605	6.3.2.1	ko:K01918	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R02473	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	iECH74115_1262.ECH74115_0142,iECSP_1301.ECSP_0134,iECs_1301.ECs0137,iG2583_1286.G2583_0137,iZ_1308.Z0144	Pantoate_ligase
HKD2_k127_3954282_1	323261.Noc_0340	1.843e-149	497.0	COG1600@1|root,COG1600@2|Bacteria,1MV1H@1224|Proteobacteria,1RMD9@1236|Gammaproteobacteria,1WWZ4@135613|Chromatiales	135613|Chromatiales	C	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)	queG	-	1.17.99.6	ko:K18979	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DUF1730,Fer4_16
HKD2_k127_3954282_0	396588.Tgr7_0892	8.498e-153	514.0	COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,1MU1Q@1224|Proteobacteria,1RMPS@1236|Gammaproteobacteria,1WW1V@135613|Chromatiales	135613|Chromatiales	G	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	-	4.2.1.136,5.1.99.6	ko:K17758,ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	Carb_kinase,YjeF_N
HKD2_k127_3954282_9	314278.NB231_15448	2.907e-33	136.0	COG0802@1|root,COG0802@2|Bacteria,1RGYU@1224|Proteobacteria,1S6IB@1236|Gammaproteobacteria,1WYI3@135613|Chromatiales	135613|Chromatiales	S	Threonylcarbamoyl adenosine biosynthesis protein TsaE	-	-	-	ko:K06925	-	-	-	-	ko00000,ko03016	-	-	-	TsaE
HKD2_k127_3954282_3	472759.Nhal_3430	8.135e-100	340.0	COG0860@1|root,COG1388@1|root,COG0860@2|Bacteria,COG1388@2|Bacteria,1MUQK@1224|Proteobacteria,1RMP1@1236|Gammaproteobacteria,1WX8Q@135613|Chromatiales	135613|Chromatiales	M	Cell wall hydrolase autolysin	-	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	AMIN,Amidase_3,LysM
HKD2_k127_3954282_10	172088.AUGA01000002_gene6105	3.583e-06	49.0	COG2909@1|root,COG2909@2|Bacteria,1MVZZ@1224|Proteobacteria,2U296@28211|Alphaproteobacteria,3K1G7@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	ko:K03556	-	-	-	-	ko00000,ko03000	-	-	-	AAA_16,GerE
HKD2_k127_3991012_0	452637.Oter_0894	0.0	2517.0	COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,46U9T@74201|Verrucomicrobia,3K7GP@414999|Opitutae	414999|Opitutae	E	glutamate synthase	-	-	1.4.7.1	ko:K00284	ko00630,ko00910,ko01120,map00630,map00910,map01120	-	R00021,R10086	RC00006,RC00010	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
HKD2_k127_3991012_1	452637.Oter_0895	3.743e-238	805.0	COG0493@1|root,COG0493@2|Bacteria,46T1M@74201|Verrucomicrobia,3K775@414999|Opitutae	414999|Opitutae	E	TIGRFAM glutamate synthase, NADH NADPH, small subunit	-	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4_20,Pyr_redox_2
HKD2_k127_3991012_11	62928.azo1544	6.958e-96	346.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,2KV9J@206389|Rhodocyclales	206389|Rhodocyclales	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS_4,PAS_9
HKD2_k127_3991012_3	640081.Dsui_0665	1.535e-180	577.0	COG2326@1|root,COG2326@2|Bacteria,1MVE2@1224|Proteobacteria,2VGZV@28216|Betaproteobacteria,2KUW9@206389|Rhodocyclales	206389|Rhodocyclales	S	Polyphosphate kinase 2 (PPK2)	-	-	2.7.4.1	ko:K22468	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PPK2
HKD2_k127_3991012_24	1116369.KB890024_gene1232	1.301e-21	101.0	arCOG05203@1|root,31A0K@2|Bacteria,1RHZR@1224|Proteobacteria,2U9JR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3991012_23	1168034.FH5T_20765	8.148e-26	118.0	COG4589@1|root,COG4589@2|Bacteria,4NT8F@976|Bacteroidetes,2FW9W@200643|Bacteroidia	976|Bacteroidetes	S	Cytidylyltransferase family	-	-	2.7.7.41	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_1
HKD2_k127_3991012_27	1463920.JOGB01000010_gene6708	1.401e-13	84.0	COG0671@1|root,COG1597@1|root,COG0671@2|Bacteria,COG1597@2|Bacteria,2GJ3K@201174|Actinobacteria	201174|Actinobacteria	I	Diacylglycerol kinase	-	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	DAGK_cat,PAP2
HKD2_k127_3991012_22	1122621.ATZA01000059_gene4147	3.456e-27	118.0	COG0558@1|root,COG0558@2|Bacteria,4NHGH@976|Bacteroidetes,1IT19@117747|Sphingobacteriia	976|Bacteroidetes	I	CDP-alcohol phosphatidyltransferase	-	-	2.7.8.5	ko:K00995	ko00564,ko01100,map00564,map01100	-	R01801	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
HKD2_k127_3991012_17	62928.azo2599	5.719e-49	178.0	COG0662@1|root,COG0662@2|Bacteria,1N40H@1224|Proteobacteria,2VWGU@28216|Betaproteobacteria,2KZHA@206389|Rhodocyclales	206389|Rhodocyclales	G	Auxin binding protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3991012_12	62928.azo2600	7.89e-95	319.0	COG0583@1|root,COG0583@2|Bacteria,1MW16@1224|Proteobacteria,2VHFY@28216|Betaproteobacteria	28216|Betaproteobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HKD2_k127_3991012_2	414684.RC1_0226	1.925e-187	601.0	COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,2TTB9@28211|Alphaproteobacteria,2JZIB@204441|Rhodospirillales	204441|Rhodospirillales	I	Carboxyl transferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Carboxyl_trans
HKD2_k127_3991012_10	1108045.GORHZ_053_00570	4.805e-96	328.0	COG0300@1|root,COG0300@2|Bacteria,2IIVW@201174|Actinobacteria,4GE8H@85026|Gordoniaceae	201174|Actinobacteria	S	NAD(P)H-binding	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HKD2_k127_3991012_29	290397.Adeh_1693	3.653e-08	58.0	COG3975@1|root,COG3975@2|Bacteria,1MUHZ@1224|Proteobacteria,42YBA@68525|delta/epsilon subdivisions,2WUP5@28221|Deltaproteobacteria,2YX31@29|Myxococcales	1224|Proteobacteria	S	Peptidase, M61	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M61,TPR_3
HKD2_k127_3991012_28	682795.AciX8_4813	1.113e-11	70.0	COG3975@1|root,COG3975@2|Bacteria,3Y411@57723|Acidobacteria,2JI4Z@204432|Acidobacteriia	204432|Acidobacteriia	S	PFAM peptidase M61	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M61
HKD2_k127_3991012_20	298653.Franean1_6325	3.018e-31	136.0	COG4627@1|root,COG4627@2|Bacteria,2GP9I@201174|Actinobacteria	201174|Actinobacteria	S	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
HKD2_k127_3991012_15	1121918.ARWE01000001_gene1848	1.028e-55	203.0	COG0545@1|root,COG0545@2|Bacteria,1RDA1@1224|Proteobacteria,42QU4@68525|delta/epsilon subdivisions,2WMRQ@28221|Deltaproteobacteria,43SHI@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase	-	-	5.2.1.8	ko:K01802,ko:K03772,ko:K03773	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	FKBP_C,FKBP_N
HKD2_k127_3991012_14	522306.CAP2UW1_1606	5.354e-87	297.0	COG2267@1|root,COG2267@2|Bacteria,1R41P@1224|Proteobacteria,2VNV3@28216|Betaproteobacteria	28216|Betaproteobacteria	I	PFAM alpha beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_4
HKD2_k127_3991012_5	1121106.JQKB01000034_gene6005	1.665e-127	425.0	COG0604@1|root,COG0604@2|Bacteria,1MX8A@1224|Proteobacteria,2TR1J@28211|Alphaproteobacteria,2JPHC@204441|Rhodospirillales	204441|Rhodospirillales	C	COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases	-	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
HKD2_k127_3991012_26	522306.CAP2UW1_0134	4.031e-18	88.0	2CHK6@1|root,333A9@2|Bacteria,1N9I7@1224|Proteobacteria,2VWH1@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3991012_8	1192034.CAP_1230	3.533e-106	355.0	COG0463@1|root,COG0463@2|Bacteria	2|Bacteria	M	Glycosyl transferase, family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HKD2_k127_3991012_7	1122604.JONR01000003_gene1413	2.508e-110	361.0	COG3752@1|root,COG3752@2|Bacteria,1RD8F@1224|Proteobacteria,1S3R5@1236|Gammaproteobacteria,1XA2S@135614|Xanthomonadales	135614|Xanthomonadales	S	Phospholipid methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	DUF1295
HKD2_k127_3991012_19	765912.Thimo_2346	2.966e-38	152.0	COG1993@1|root,COG1993@2|Bacteria,1RH30@1224|Proteobacteria,1SFPH@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Uncharacterized ACR, COG1993	-	-	-	-	-	-	-	-	-	-	-	-	DUF190
HKD2_k127_3991012_16	1454004.AW11_03451	7.825e-54	191.0	COG0239@1|root,COG0239@2|Bacteria,1MZNH@1224|Proteobacteria,2VUBZ@28216|Betaproteobacteria,1KQXJ@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	U	Important for reducing fluoride concentration in the cell, thus reducing its toxicity	crcB	-	-	ko:K06199	-	-	-	-	ko00000,ko02000	1.A.43.1,1.A.43.2,1.A.43.3	-	-	CRCB
HKD2_k127_3991012_9	1304883.KI912532_gene3026	1.884e-103	356.0	COG1538@1|root,COG1538@2|Bacteria,1MWX5@1224|Proteobacteria,2VHU4@28216|Betaproteobacteria,2KXX0@206389|Rhodocyclales	206389|Rhodocyclales	M	CyaE is necessary for transport of calmodulin-sensitive adenylate cyclase-hemolysin (cyclolysin)	-	-	-	-	-	-	-	-	-	-	-	-	OEP
HKD2_k127_3991012_6	1454004.AW11_00605	9.026e-120	401.0	COG0845@1|root,COG0845@2|Bacteria,1MU8D@1224|Proteobacteria,2VH9K@28216|Betaproteobacteria	28216|Betaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	HlyD_D23
HKD2_k127_3991012_13	1304883.KI912532_gene3024	1.203e-93	316.0	COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,2VKEW@28216|Betaproteobacteria,2KXSK@206389|Rhodocyclales	206389|Rhodocyclales	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD2_k127_3991012_4	395494.Galf_1762	1.084e-171	547.0	COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,2W3RM@28216|Betaproteobacteria,44VN6@713636|Nitrosomonadales	28216|Betaproteobacteria	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HKD2_k127_3991012_25	158500.BV97_04268	1.267e-18	89.0	COG5517@1|root,COG5517@2|Bacteria,1NDVD@1224|Proteobacteria	1224|Proteobacteria	Q	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_4
HKD2_k127_3991012_18	748280.NH8B_3096	1.032e-40	162.0	COG3103@1|root,COG3103@2|Bacteria	2|Bacteria	T	Sh3 type 3 domain protein	-	-	3.4.21.96	ko:K01361	-	-	-	-	ko00000,ko01000,ko01002,ko03110	-	-	-	CW_binding_2,PA,Peptidase_S8,SH3_3,SpoIID,fn3_5
HKD2_k127_4047811_5	1415780.JPOG01000001_gene2435	1.399e-30	127.0	COG2836@1|root,COG2836@2|Bacteria,1RIGJ@1224|Proteobacteria,1S5V1@1236|Gammaproteobacteria,1X66I@135614|Xanthomonadales	135614|Xanthomonadales	S	Cytochrome C biogenesis protein transmembrane region	-	-	-	ko:K09792	-	-	-	-	ko00000	-	-	-	DsbD_2
HKD2_k127_4047811_6	1415780.JPOG01000001_gene2436	4.198e-13	72.0	COG3197@1|root,COG3197@2|Bacteria,1QSIT@1224|Proteobacteria,1RW0B@1236|Gammaproteobacteria,1X8QU@135614|Xanthomonadales	135614|Xanthomonadales	P	Cytochrome oxidase maturation protein	-	-	-	-	-	-	-	-	-	-	-	-	FixS
HKD2_k127_4047811_0	1415780.JPOG01000001_gene2437	2.302e-232	744.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,1RN2C@1236|Gammaproteobacteria,1X32B@135614|Xanthomonadales	135614|Xanthomonadales	P	COG2217 Cation transport ATPase	-	-	3.6.3.4	ko:K01533	-	-	R00086	RC00002	ko00000,ko01000	3.A.3.5	-	-	ATPase-cat_bd,E1-E2_ATPase,HMA,Hydrolase
HKD2_k127_4047811_9	292415.Tbd_0638	6.902e-09	59.0	COG3198@1|root,COG3198@2|Bacteria,1N75J@1224|Proteobacteria,2VTYE@28216|Betaproteobacteria,1KRV3@119069|Hydrogenophilales	119069|Hydrogenophilales	S	FixH	-	-	-	ko:K09926	-	-	-	-	ko00000	-	-	-	FixH
HKD2_k127_4047811_1	187272.Mlg_1877	5.045e-184	586.0	COG0348@1|root,COG0348@2|Bacteria,1MVFY@1224|Proteobacteria,1RMDI@1236|Gammaproteobacteria,1WWVW@135613|Chromatiales	135613|Chromatiales	C	TIGRFAM cytochrome c oxidase accessory protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_18,Fer4_5,FixG_C
HKD2_k127_4047811_8	1123377.AUIV01000005_gene1731	1.727e-12	72.0	2EFX9@1|root,339PI@2|Bacteria,1NI0D@1224|Proteobacteria,1SGKH@1236|Gammaproteobacteria,1X7EB@135614|Xanthomonadales	135614|Xanthomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4047811_3	1123253.AUBD01000016_gene1972	8.128e-102	342.0	COG2010@1|root,COG2010@2|Bacteria,1MUCW@1224|Proteobacteria,1RPYJ@1236|Gammaproteobacteria,1X4SS@135614|Xanthomonadales	135614|Xanthomonadales	C	C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex	-	-	-	ko:K00406	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002	3.D.4.3	-	-	Cytochrome_CBB3,FixP_N
HKD2_k127_4047811_7	1121943.KB899989_gene3359	4.905e-13	70.0	COG4736@1|root,COG4736@2|Bacteria,1NGAN@1224|Proteobacteria,1SGJ2@1236|Gammaproteobacteria,1XMQT@135619|Oceanospirillales	135619|Oceanospirillales	O	Cbb3-type cytochrome oxidase component FixQ	ccoQ	-	-	ko:K00407	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002	3.D.4.3	-	-	FixQ
HKD2_k127_4047811_4	1123377.AUIV01000005_gene1734	1.439e-95	317.0	COG2993@1|root,COG2993@2|Bacteria,1MXEY@1224|Proteobacteria,1RPU6@1236|Gammaproteobacteria,1X3EF@135614|Xanthomonadales	135614|Xanthomonadales	C	COG2993 Cbb3-type cytochrome oxidase, cytochrome c subunit	-	-	-	ko:K00405	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002	3.D.4.3	-	-	FixO
HKD2_k127_4047811_2	2340.JV46_10130	6.367e-119	384.0	COG3278@1|root,COG3278@2|Bacteria,1MU18@1224|Proteobacteria,1RM7I@1236|Gammaproteobacteria,1J4J5@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Belongs to the heme-copper respiratory oxidase family	ccoN	-	1.9.3.1	ko:K00404	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	COX1
HKD2_k127_4048329_0	1121875.KB907549_gene1715	5.95e-106	366.0	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,4NFW7@976|Bacteroidetes,1HZQR@117743|Flavobacteriia	976|Bacteroidetes	K	COGs COG5616 integral membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18,TPR_8
HKD2_k127_4048329_2	551275.KB899545_gene2773	3.793e-51	192.0	COG0803@1|root,COG0803@2|Bacteria,1R91T@1224|Proteobacteria,2TRDQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Belongs to the bacterial solute-binding protein 9 family	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_7
HKD2_k127_4048329_1	296591.Bpro_0144	3.333e-64	225.0	COG0346@1|root,COG0346@2|Bacteria,1RHD4@1224|Proteobacteria,2VSJM@28216|Betaproteobacteria,4AEJT@80864|Comamonadaceae	28216|Betaproteobacteria	E	PFAM Glyoxalase bleomycin resistance protein dioxygenase	-	-	-	ko:K08234	-	-	-	-	ko00000	-	-	-	Glyoxalase
HKD2_k127_4054917_6	661367.LLO_1205	9.066e-16	80.0	COG0454@1|root,COG1670@1|root,COG0456@2|Bacteria,COG1670@2|Bacteria,1RHZS@1224|Proteobacteria,1S6D7@1236|Gammaproteobacteria,1JE9U@118969|Legionellales	118969|Legionellales	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10,Acetyltransf_3
HKD2_k127_4054917_2	314285.KT71_08685	4.361e-39	151.0	COG3316@1|root,COG3316@2|Bacteria,1MWZ2@1224|Proteobacteria,1RRC2@1236|Gammaproteobacteria,1J8NP@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	L	DDE domain	-	-	-	ko:K07498	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS240
HKD2_k127_4054917_7	1041146.ATZB01000036_gene722	9.159e-05	48.0	COG3119@1|root,COG3119@2|Bacteria,1MUJH@1224|Proteobacteria,2TSB8@28211|Alphaproteobacteria,4B9EB@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	Arylsulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	DUF4994,Sulfatase,Sulfatase_C
HKD2_k127_4054917_1	1230476.C207_05615	4.819e-40	160.0	COG5662@1|root,COG5662@2|Bacteria,1MV95@1224|Proteobacteria,2TVRG@28211|Alphaproteobacteria,3JRXS@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	Putative zinc-finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
HKD2_k127_4054917_4	395019.Bmul_1398	5.386e-37	145.0	COG1595@1|root,COG1595@2|Bacteria,1PT8E@1224|Proteobacteria,2W1XX@28216|Betaproteobacteria,1K2WI@119060|Burkholderiaceae	28216|Betaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD2_k127_4054917_0	216591.BCAM1960	5.449e-129	421.0	COG1409@1|root,COG1409@2|Bacteria,1MUQJ@1224|Proteobacteria,2VJNP@28216|Betaproteobacteria,1K36Q@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Metallophosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
HKD2_k127_4054917_3	1112212.JH584235_gene3412	3.206e-38	156.0	COG3474@1|root,COG3474@2|Bacteria,1N15D@1224|Proteobacteria,2UCF5@28211|Alphaproteobacteria,2K6IZ@204457|Sphingomonadales	204457|Sphingomonadales	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C
HKD2_k127_4054917_5	570952.ATVH01000017_gene1822	8.144e-20	92.0	COG2801@1|root,COG2801@2|Bacteria,1NAXT@1224|Proteobacteria,2UVUA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4143082_5	1279017.AQYJ01000020_gene1277	4.262e-38	160.0	COG1566@1|root,COG1566@2|Bacteria,1RJ3I@1224|Proteobacteria,1S7BS@1236|Gammaproteobacteria,46ACD@72275|Alteromonadaceae	1236|Gammaproteobacteria	V	Protein of unknown function (DUF3667)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3667
HKD2_k127_4143082_6	84531.JMTZ01000032_gene292	1.386e-21	109.0	2EIF9@1|root,33C6N@2|Bacteria,1ND19@1224|Proteobacteria,1SF3W@1236|Gammaproteobacteria,1XB57@135614|Xanthomonadales	135614|Xanthomonadales	S	Domain of unknown function (DUF4286)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4286
HKD2_k127_4143082_4	977880.RALTA_B1422	4.978e-78	268.0	COG2267@1|root,COG2267@2|Bacteria,1MX0N@1224|Proteobacteria,2WGH6@28216|Betaproteobacteria,1K4Q0@119060|Burkholderiaceae	28216|Betaproteobacteria	I	3-oxoadipate enol-lactonase	pcaD	-	3.1.1.24	ko:K01055	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00568	R02991	RC00825	ko00000,ko00001,ko00002,ko01000	-	-	-	Abhydrolase_1,Abhydrolase_4,CMD
HKD2_k127_4143082_2	450851.PHZ_c2025	4.817e-217	683.0	COG1062@1|root,COG1062@2|Bacteria,1MUK4@1224|Proteobacteria,2TT67@28211|Alphaproteobacteria,2KFG5@204458|Caulobacterales	204458|Caulobacterales	C	Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily	-	-	1.1.1.1,1.1.1.284	ko:K00121	ko00010,ko00071,ko00350,ko00625,ko00626,ko00680,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,ko05204,map00010,map00071,map00350,map00625,map00626,map00680,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01200,map01220,map05204	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R06983,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01715,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
HKD2_k127_4143082_3	1336243.JAEA01000001_gene1905	7.183e-125	406.0	COG0627@1|root,COG0627@2|Bacteria,1MUID@1224|Proteobacteria,2TQSM@28211|Alphaproteobacteria,1JSKD@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	Serine hydrolase involved in the detoxification of formaldehyde	fghA	-	3.1.2.12	ko:K01070	ko00680,ko01120,ko01200,map00680,map01120,map01200	-	R00527	RC00167,RC00320	ko00000,ko00001,ko01000	-	CE1	-	Esterase
HKD2_k127_4143082_0	998088.B565_1194	1.805e-292	919.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,1RPM5@1236|Gammaproteobacteria,1Y52N@135624|Aeromonadales	135624|Aeromonadales	I	Domain of unknown function (DUF1974)	-	-	-	ko:K06445	ko00071,ko01100,ko01212,map00071,map01100,map01212	M00087	R01175,R01279,R03777,R03857,R03990,R04751,R04754	RC00052,RC00076	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_N,DUF1974
HKD2_k127_4143082_1	1191523.MROS_1774	3.204e-223	698.0	COG0243@1|root,COG0243@2|Bacteria	2|Bacteria	C	molybdopterin cofactor binding	-	-	1.8.5.5	ko:K08352	ko00920,ko01120,map00920,map01120	-	R10149	RC02823	ko00000,ko00001,ko01000,ko02000	5.A.3.5	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
HKD2_k127_4147645_3	1297742.A176_02095	8.156e-83	287.0	COG0132@1|root,COG0132@2|Bacteria,1MYAE@1224|Proteobacteria	1224|Proteobacteria	H	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring	-	-	-	-	-	-	-	-	-	-	-	-	DUF1611
HKD2_k127_4147645_7	903818.KI912269_gene301	2.128e-51	199.0	COG0002@1|root,COG0002@2|Bacteria,3Y450@57723|Acidobacteria	57723|Acidobacteria	E	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde	argC	-	1.2.1.38	ko:K00145	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R03443	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
HKD2_k127_4147645_4	1121920.AUAU01000010_gene42	1.504e-81	286.0	COG4992@1|root,COG4992@2|Bacteria,3Y36P@57723|Acidobacteria	57723|Acidobacteria	E	PFAM Aminotransferase class-III	argD	-	2.6.1.11,2.6.1.17	ko:K00821	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
HKD2_k127_4147645_5	518766.Rmar_0946	1.414e-71	254.0	COG0078@1|root,COG0078@2|Bacteria,4NEYX@976|Bacteroidetes,1FJUC@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	H	Belongs to the ATCase OTCase family	argF	GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.1.3.11,2.1.3.9	ko:K09065,ko:K13043	ko00220,ko01100,ko01230,map00220,map01100,map01230	M00845	R07245,R08937	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
HKD2_k127_4147645_6	1144275.COCOR_02389	1.784e-71	265.0	COG0548@1|root,COG0548@2|Bacteria,1MU17@1224|Proteobacteria,42N8G@68525|delta/epsilon subdivisions,2WKBC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	F	Belongs to the acetylglutamate kinase family. ArgB subfamily	argB	GO:0003674,GO:0003824,GO:0003991,GO:0005488,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0019752,GO:0031406,GO:0034618,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.2.8	ko:K00930	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R02649	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase
HKD2_k127_4147645_1	309807.SRU_2221	7.68e-91	317.0	COG0165@1|root,COG0165@2|Bacteria,4NFCY@976|Bacteroidetes,1FJSI@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	E	Lyase	argH	GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.3.2.1	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01086	RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Lyase_1
HKD2_k127_4147645_8	1297742.A176_05007	1.679e-47	174.0	COG2510@1|root,COG2510@2|Bacteria,1RJ4E@1224|Proteobacteria,43A86@68525|delta/epsilon subdivisions,2X8VA@28221|Deltaproteobacteria,2Z0JB@29|Myxococcales	28221|Deltaproteobacteria	S	EamA-like transporter family	-	-	-	ko:K08978	-	-	-	-	ko00000,ko02000	2.A.7.2	-	-	EamA
HKD2_k127_4147645_2	264462.Bd0930	1.382e-86	297.0	COG0693@1|root,COG0693@2|Bacteria,1NBJV@1224|Proteobacteria,437IR@68525|delta/epsilon subdivisions,2MTRY@213481|Bdellovibrionales,2X2SJ@28221|Deltaproteobacteria	213481|Bdellovibrionales	S	ThiJ/PfpI family-like	-	-	3.5.1.124	ko:K05520	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	ThiJ_like
HKD2_k127_4147645_0	243365.CV_1441	2.494e-166	529.0	COG2220@1|root,COG2220@2|Bacteria,1MV20@1224|Proteobacteria,2VKI0@28216|Betaproteobacteria,2KQSB@206351|Neisseriales	206351|Neisseriales	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
HKD2_k127_4147645_9	861299.J421_5867	8.32e-44	164.0	2CVTP@1|root,32SY9@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF1203)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1203
HKD2_k127_4191506_15	1123360.thalar_02885	5.178e-12	67.0	COG0843@1|root,COG0843@2|Bacteria,1R57U@1224|Proteobacteria,2U068@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Cytochrome C and Quinol oxidase polypeptide I	-	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
HKD2_k127_4191506_8	522306.CAP2UW1_1789	1.042e-74	261.0	COG0109@1|root,COG0109@2|Bacteria,1MW3S@1224|Proteobacteria,2VM89@28216|Betaproteobacteria	28216|Betaproteobacteria	O	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group	-	-	2.5.1.141	ko:K02257	ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714	M00154	R07411	RC01786	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029	-	-	-	UbiA
HKD2_k127_4191506_10	1244869.H261_01537	3.883e-59	214.0	COG1999@1|root,COG1999@2|Bacteria	2|Bacteria	M	signal sequence binding	sco	-	-	ko:K07152	-	-	-	-	ko00000,ko03029	-	-	-	SCO1-SenC
HKD2_k127_4191506_5	1123360.thalar_02888	1.191e-174	571.0	COG1145@1|root,COG1290@1|root,COG1908@1|root,COG1145@2|Bacteria,COG1290@2|Bacteria,COG1908@2|Bacteria,1QSPU@1224|Proteobacteria,2UQID@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Methyl-viologen-reducing hydrogenase, delta subunit	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_B,FlpD
HKD2_k127_4191506_13	1454004.AW11_01051	3.427e-27	129.0	2CB7M@1|root,31H4T@2|Bacteria,1MYWT@1224|Proteobacteria,2VSTJ@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4191506_14	1123360.thalar_02890	4.83e-26	120.0	COG2703@1|root,COG2703@2|Bacteria	2|Bacteria	P	oxygen carrier activity	-	-	-	ko:K07216	-	-	-	-	ko00000	-	-	-	Hemerythrin
HKD2_k127_4191506_9	1266925.JHVX01000003_gene575	7.495e-67	236.0	COG0204@1|root,COG0204@2|Bacteria,1MY51@1224|Proteobacteria,2VNAX@28216|Betaproteobacteria,372BP@32003|Nitrosomonadales	28216|Betaproteobacteria	I	PFAM Phospholipid glycerol acyltransferase	nlaB	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
HKD2_k127_4191506_3	472759.Nhal_0219	7.911e-228	738.0	COG0751@1|root,COG0751@2|Bacteria,1MV2F@1224|Proteobacteria,1RNR3@1236|Gammaproteobacteria,1WWSJ@135613|Chromatiales	135613|Chromatiales	J	Glycyl-tRNA synthetase beta subunit	glyS	-	6.1.1.14	ko:K01879	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_1,tRNA_synt_2f
HKD2_k127_4191506_6	472759.Nhal_0218	1.051e-159	512.0	COG0752@1|root,COG0752@2|Bacteria,1MVCJ@1224|Proteobacteria,1RMYI@1236|Gammaproteobacteria,1WWUE@135613|Chromatiales	135613|Chromatiales	J	glycyl-tRNA synthetase alpha subunit	glyQ	-	6.1.1.14	ko:K01878	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2e
HKD2_k127_4191506_7	1166018.FAES_3608	1.6e-86	295.0	COG1526@1|root,COG1526@2|Bacteria,4NFJB@976|Bacteroidetes,47MUW@768503|Cytophagia	976|Bacteroidetes	C	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH	fdhD	-	-	ko:K02379	-	-	-	-	ko00000	-	-	-	FdhD-NarQ
HKD2_k127_4191506_11	648885.KB316283_gene2915	1.249e-36	151.0	COG4583@1|root,COG4583@2|Bacteria,1N68D@1224|Proteobacteria,2UDJV@28211|Alphaproteobacteria,1JU74@119045|Methylobacteriaceae	28211|Alphaproteobacteria	E	Sarcosine oxidase, gamma subunit	-	-	1.5.3.1,1.5.99.5	ko:K00305,ko:K22087	ko00260,ko00680,ko01100,ko01120,map00260,map00680,map01100,map01120	-	R00609,R00610	RC00060,RC00190,RC00557	ko00000,ko00001,ko01000	-	-	-	SoxG
HKD2_k127_4191506_0	1502851.FG93_00744	0.0	1334.0	COG0404@1|root,COG0446@1|root,COG0404@2|Bacteria,COG0446@2|Bacteria,1MVEK@1224|Proteobacteria,2TTD7@28211|Alphaproteobacteria,3JTMR@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Glycine cleavage T-protein C-terminal barrel domain	soxA	-	1.5.3.1,1.5.99.5	ko:K00302,ko:K22086	ko00260,ko00680,ko01100,ko01120,map00260,map00680,map01100,map01120	-	R00609,R00610	RC00060,RC00190,RC00557	ko00000,ko00001,ko01000	-	-	-	FAD_oxidored,Fer2_4,GCV_T,GCV_T_C,Pyr_redox_2
HKD2_k127_4191506_12	1120792.JAFV01000001_gene3869	6.72e-36	138.0	COG4311@1|root,COG4311@2|Bacteria,1N8ED@1224|Proteobacteria,2UFIN@28211|Alphaproteobacteria,370W5@31993|Methylocystaceae	28211|Alphaproteobacteria	E	Sarcosine oxidase, delta subunit family	soxD	-	1.5.3.1,1.5.99.5	ko:K00304,ko:K22085	ko00260,ko00680,ko01100,ko01120,map00260,map00680,map01100,map01120	-	R00609,R00610	RC00060,RC00190,RC00557	ko00000,ko00001,ko01000	-	-	-	SoxD
HKD2_k127_4191506_4	288000.BBta_1949	2.899e-224	704.0	COG0665@1|root,COG0665@2|Bacteria,1MVM6@1224|Proteobacteria,2TRM7@28211|Alphaproteobacteria,3JUTE@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	FAD dependent oxidoreductase	soxB	-	1.5.3.1,1.5.99.5	ko:K00303,ko:K22084	ko00260,ko00680,ko01100,ko01120,map00260,map00680,map01100,map01120	-	R00609,R00610	RC00060,RC00190,RC00557	ko00000,ko00001,ko01000	-	-	-	DAO
HKD2_k127_4191506_1	1320556.AVBP01000001_gene4454	0.0	1267.0	COG0404@1|root,COG0665@1|root,COG0404@2|Bacteria,COG0665@2|Bacteria,1MUXJ@1224|Proteobacteria,2TRGS@28211|Alphaproteobacteria,43NEJ@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	Belongs to the GcvT family	-	-	1.5.8.4	ko:K00315	ko00260,ko01100,map00260,map01100	-	R01565	RC00181	ko00000,ko00001,ko01000	-	-	-	DAO,FAO_M,GCV_T,GCV_T_C
HKD2_k127_4191506_2	331869.BAL199_29255	1.211e-232	729.0	COG5598@1|root,COG5598@2|Bacteria,1R7R2@1224|Proteobacteria,2TUNM@28211|Alphaproteobacteria,4BTAN@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	H	Trimethylamine methyltransferase (MTTB)	-	-	2.1.1.250	ko:K14083	ko00680,ko01120,ko01200,map00680,map01120,map01200	M00563	R09124,R10016	RC00035,RC00732,RC01144,RC02984	ko00000,ko00001,ko00002,ko01000	-	-	-	MTTB
HKD2_k127_4215173_1	365044.Pnap_1828	9.067e-132	430.0	COG1073@1|root,COG1073@2|Bacteria,1RAV7@1224|Proteobacteria,2VQ93@28216|Betaproteobacteria,4AAPM@80864|Comamonadaceae	28216|Betaproteobacteria	S	alpha beta	-	-	-	-	-	-	-	-	-	-	-	-	LIP,Peptidase_S9
HKD2_k127_4215173_0	1454004.AW11_00968	1.817e-132	436.0	COG0628@1|root,COG0628@2|Bacteria,1MW0B@1224|Proteobacteria,2VHDW@28216|Betaproteobacteria,1KR1G@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
HKD2_k127_4215173_2	1042209.HK44_007370	1.163e-32	127.0	COG1502@1|root,COG1502@2|Bacteria,1MWUW@1224|Proteobacteria,1RPQG@1236|Gammaproteobacteria,1YMB5@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	I	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol	-	-	-	ko:K06131	ko00564,ko01100,map00564,map01100	-	R07390	RC00017	ko00000,ko00001,ko01000	-	-	-	PLDc_2
HKD2_k127_4220723_2	666685.R2APBS1_0805	4.414e-88	301.0	COG0845@1|root,COG0845@2|Bacteria,1NQDN@1224|Proteobacteria,1RRFE@1236|Gammaproteobacteria,1X3QX@135614|Xanthomonadales	135614|Xanthomonadales	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	ybjY	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
HKD2_k127_4220723_1	1122185.N792_12410	6.649e-104	344.0	COG1136@1|root,COG1136@2|Bacteria,1NHCD@1224|Proteobacteria,1RNIX@1236|Gammaproteobacteria,1X4CB@135614|Xanthomonadales	135614|Xanthomonadales	V	abc transporter atp-binding protein	ycfV	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD2_k127_4220723_0	1120953.AUBH01000001_gene915	5.644e-124	411.0	COG0577@1|root,COG0577@2|Bacteria,1QSVW@1224|Proteobacteria,1RPBM@1236|Gammaproteobacteria,465M6@72275|Alteromonadaceae	1236|Gammaproteobacteria	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HKD2_k127_4220723_3	983545.Glaag_1960	2.25e-73	259.0	COG0577@1|root,COG0577@2|Bacteria,1MXFC@1224|Proteobacteria,1RQX0@1236|Gammaproteobacteria,46698@72275|Alteromonadaceae	1236|Gammaproteobacteria	V	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HKD2_k127_4231768_24	522306.CAP2UW1_4153	2e-19	95.0	COG3175@1|root,COG3175@2|Bacteria,1RDTU@1224|Proteobacteria,2VHRQ@28216|Betaproteobacteria,1KQT5@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	O	Cytochrome c oxidase assembly protein CtaG/Cox11	ctaG	-	-	ko:K02258	ko00190,ko01100,ko04714,map00190,map01100,map04714	M00154	-	-	ko00000,ko00001,ko00002,ko03029	3.D.4.8	-	-	CtaG_Cox11
HKD2_k127_4231768_1	1335757.SPICUR_01585	6.316e-280	868.0	COG0843@1|root,COG0843@2|Bacteria,1MU7S@1224|Proteobacteria,1RPC3@1236|Gammaproteobacteria,1WWX1@135613|Chromatiales	135613|Chromatiales	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	-	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
HKD2_k127_4231768_10	1122603.ATVI01000001_gene1931	4.803e-103	344.0	COG1622@1|root,COG2010@1|root,COG1622@2|Bacteria,COG2010@2|Bacteria,1MWHZ@1224|Proteobacteria,1RP4H@1236|Gammaproteobacteria,1X3IF@135614|Xanthomonadales	135614|Xanthomonadales	C	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)	ctaC	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2,COX2_TM,Cytochrome_CBB3
HKD2_k127_4231768_23	1283300.ATXB01000001_gene1077	1.3e-20	100.0	COG5488@1|root,COG5488@2|Bacteria,1N9B7@1224|Proteobacteria,1SF1J@1236|Gammaproteobacteria,1XGQI@135618|Methylococcales	135618|Methylococcales	S	Integral membrane protein (DUF2244)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2244
HKD2_k127_4231768_16	765911.Thivi_1766	2.113e-54	203.0	COG0132@1|root,COG0132@2|Bacteria,1RDRK@1224|Proteobacteria,1RSHS@1236|Gammaproteobacteria,1WXWI@135613|Chromatiales	135613|Chromatiales	H	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring	bioD	-	6.3.3.3	ko:K01935	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03182	RC00868	ko00000,ko00001,ko00002,ko01000	-	-	-	AAA_26
HKD2_k127_4231768_12	713586.KB900536_gene1821	3.833e-88	314.0	COG0500@1|root,COG2226@2|Bacteria,1PA5F@1224|Proteobacteria,1RY7A@1236|Gammaproteobacteria,1WW45@135613|Chromatiales	135613|Chromatiales	H	Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway	bioC	-	2.1.1.197	ko:K02169	ko00780,ko01100,map00780,map01100	M00572	R09543	RC00003,RC00460	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_11
HKD2_k127_4231768_13	1121013.P873_13595	1.513e-67	247.0	COG2267@1|root,COG2267@2|Bacteria,1N2R9@1224|Proteobacteria,1T1K8@1236|Gammaproteobacteria,1X3DZ@135614|Xanthomonadales	135614|Xanthomonadales	I	The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters	bioH	-	3.1.1.85	ko:K02170	ko00780,ko01100,map00780,map01100	M00572	R09725	RC00460,RC00461	ko00000,ko00001,ko00002,ko01000	-	-	-	Abhydrolase_1,Abhydrolase_6
HKD2_k127_4231768_6	203122.Sde_3138	3.542e-134	440.0	COG0156@1|root,COG0156@2|Bacteria,1MVVH@1224|Proteobacteria,1RNS6@1236|Gammaproteobacteria,4655Y@72275|Alteromonadaceae	1236|Gammaproteobacteria	E	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide	bioF	GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008710,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0017144,GO:0018130,GO:0019752,GO:0019842,GO:0030170,GO:0032787,GO:0034641,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0070279,GO:0071704,GO:0072330,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.3.1.47	ko:K00652	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03210,R10124	RC00004,RC00039,RC02725	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	iEC55989_1330.EC55989_0819,iECO111_1330.ECO111_0837,iECO26_1355.ECO26_0902,iSDY_1059.SDY_0830	Aminotran_1_2
HKD2_k127_4231768_5	1122604.JONR01000043_gene3174	1.077e-140	459.0	COG0502@1|root,COG0502@2|Bacteria,1MVFF@1224|Proteobacteria,1RMEQ@1236|Gammaproteobacteria,1X3XQ@135614|Xanthomonadales	135614|Xanthomonadales	H	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism	bioB	-	2.8.1.6	ko:K01012	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R01078	RC00441	ko00000,ko00001,ko00002,ko01000	-	-	-	BATS,Radical_SAM
HKD2_k127_4231768_17	243233.MCA1124	8.974e-54	197.0	COG1040@1|root,COG1040@2|Bacteria,1RHAV@1224|Proteobacteria,1S64Q@1236|Gammaproteobacteria,1XDVG@135618|Methylococcales	135618|Methylococcales	S	Competence protein	comF	-	-	-	-	-	-	-	-	-	-	-	Pribosyltran
HKD2_k127_4231768_7	1268237.G114_00300	8.355e-131	435.0	COG3004@1|root,COG3004@2|Bacteria,1MW15@1224|Proteobacteria,1RNDE@1236|Gammaproteobacteria,1Y47Y@135624|Aeromonadales	135624|Aeromonadales	P	) H( ) antiporter that extrudes sodium in exchange for external protons	nhaA	-	-	ko:K03313	-	-	-	-	ko00000,ko02000	2.A.33.1	-	-	Na_H_antiport_1
HKD2_k127_4231768_11	472759.Nhal_0761	2.276e-99	332.0	COG0382@1|root,COG0382@2|Bacteria,1MV4Q@1224|Proteobacteria,1RMZ1@1236|Gammaproteobacteria,1WWA7@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate	ubiA	-	2.5.1.39	ko:K03179	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R05000,R05615	RC00209,RC02895	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
HKD2_k127_4231768_3	1122194.AUHU01000009_gene3165	7.875e-265	838.0	COG1200@1|root,COG1200@2|Bacteria,1MWN2@1224|Proteobacteria,1RMMQ@1236|Gammaproteobacteria,46544@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)	recG	GO:0003674,GO:0003678,GO:0003724,GO:0003824,GO:0004003,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0008186,GO:0009314,GO:0009379,GO:0009628,GO:0009987,GO:0010501,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051276,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:0140098,GO:1901360,GO:1902494	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge
HKD2_k127_4231768_18	631362.Thi970DRAFT_01519	4.228e-53	190.0	COG0251@1|root,COG0251@2|Bacteria,1MZ3J@1224|Proteobacteria,1S5XS@1236|Gammaproteobacteria,1WY7E@135613|Chromatiales	135613|Chromatiales	J	PFAM Endoribonuclease L-PSP	-	-	3.5.99.10	ko:K09022	-	-	R11098,R11099	RC03275,RC03354	ko00000,ko01000	-	-	-	Ribonuc_L-PSP
HKD2_k127_4231768_21	1419583.V466_27350	3.584e-37	145.0	COG5605@1|root,COG5605@2|Bacteria,1RH8B@1224|Proteobacteria,1S95E@1236|Gammaproteobacteria,1YTTG@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	S	Prokaryotic Cytochrome C oxidase subunit IV	-	-	-	-	-	-	-	-	-	-	-	-	COX4_pro
HKD2_k127_4231768_8	1095769.CAHF01000013_gene3384	3.626e-112	365.0	COG1845@1|root,COG1845@2|Bacteria,1MUCK@1224|Proteobacteria,2VKKS@28216|Betaproteobacteria,473Y3@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	Cytochrome c oxidase subunit III	coxP	-	1.9.3.1	ko:K02276	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.4,3.D.4.6	-	-	COX3
HKD2_k127_4231768_20	189753.AXAS01000016_gene1404	6.664e-51	191.0	COG1845@1|root,COG1845@2|Bacteria,1MXAB@1224|Proteobacteria,2TRFQ@28211|Alphaproteobacteria,3JTBK@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Cytochrome c oxidase subunit III	coxO	-	1.9.3.1	ko:K02276	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.4,3.D.4.6	-	-	COX3
HKD2_k127_4231768_0	1038869.AXAN01000063_gene4596	3.207e-307	948.0	COG0843@1|root,COG0843@2|Bacteria,1MU7S@1224|Proteobacteria,2VMNB@28216|Betaproteobacteria,1K1HE@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	coxN	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
HKD2_k127_4231768_4	1121374.KB891577_gene3209	3.375e-167	536.0	COG1622@1|root,COG2863@1|root,COG1622@2|Bacteria,COG2863@2|Bacteria,1MVYW@1224|Proteobacteria,1RY2R@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	COG1622 Heme copper-type cytochrome quinol oxidases, subunit 2	-	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2,COX2_TM,Cytochrom_C
HKD2_k127_4231768_15	1116472.MGMO_71c00030	7.885e-58	213.0	2E0NX@1|root,32W7W@2|Bacteria,1N3K6@1224|Proteobacteria,1SA9T@1236|Gammaproteobacteria,1XFTJ@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4231768_19	1244869.H261_01537	1.17e-52	213.0	COG1999@1|root,COG1999@2|Bacteria	2|Bacteria	M	signal sequence binding	sco	-	-	ko:K07152	-	-	-	-	ko00000,ko03029	-	-	-	SCO1-SenC
HKD2_k127_4231768_2	713586.KB900536_gene1923	3.353e-265	834.0	COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,1RN3H@1236|Gammaproteobacteria,1WWZ3@135613|Chromatiales	135613|Chromatiales	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	-	-	2.7.6.5,3.1.7.2	ko:K01139	ko00230,map00230	-	R00336,R00429	RC00002,RC00078	ko00000,ko00001,ko01000,ko03009	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
HKD2_k127_4231768_22	187272.Mlg_2443	3.748e-24	104.0	COG1758@1|root,COG1758@2|Bacteria,1N6TX@1224|Proteobacteria,1SCSR@1236|Gammaproteobacteria,1WYPW@135613|Chromatiales	135613|Chromatiales	K	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits	rpoZ	-	2.7.7.6	ko:K03060	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb6
HKD2_k127_4231768_14	42565.FP66_02335	3.249e-66	232.0	COG0194@1|root,COG0194@2|Bacteria,1MW92@1224|Proteobacteria,1RN09@1236|Gammaproteobacteria,1XJ5P@135619|Oceanospirillales	135619|Oceanospirillales	F	Essential for recycling GMP and indirectly, cGMP	gmk	-	2.7.4.8	ko:K00942	ko00230,ko01100,map00230,map01100	M00050	R00332,R02090	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_kin
HKD2_k127_4231768_9	1278309.KB907099_gene2927	2.698e-106	373.0	COG4105@1|root,COG4571@1|root,COG4105@2|Bacteria,COG4571@2|Bacteria,1QWIQ@1224|Proteobacteria,1S1BG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4305045_3	383381.EH30_02410	2.783e-106	370.0	COG0457@1|root,COG0457@2|Bacteria,1N0A9@1224|Proteobacteria,2TTMN@28211|Alphaproteobacteria,2K2YU@204457|Sphingomonadales	204457|Sphingomonadales	S	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_14,TPR_8
HKD2_k127_4305045_5	1268237.G114_10895	4.763e-43	159.0	2DWY1@1|root,342G1@2|Bacteria,1N2NN@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4305045_0	666685.R2APBS1_3302	3.193e-255	797.0	COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,1RPIW@1236|Gammaproteobacteria,1X5RA@135614|Xanthomonadales	135614|Xanthomonadales	Q	Amidohydrolase family	-	-	3.5.1.81	ko:K06015	-	-	R02192	RC00064,RC00328	ko00000,ko01000	-	-	-	Amidohydro_3
HKD2_k127_4305045_7	764291.STRUR_0223	5.954e-27	120.0	COG2503@1|root,COG2503@2|Bacteria	2|Bacteria	M	HAD superfamily, subfamily IIIB (Acid phosphatase)	hel	GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Acid_phosphat_B
HKD2_k127_4305045_4	1120985.AUMI01000017_gene2729	8.994e-45	172.0	COG2930@1|root,COG2930@2|Bacteria,1VBSP@1239|Firmicutes,4H54G@909932|Negativicutes	909932|Negativicutes	S	Las17-binding protein actin regulator	-	-	-	-	-	-	-	-	-	-	-	-	Ysc84
HKD2_k127_4305045_1	335543.Sfum_0593	5.852e-145	468.0	COG0628@1|root,COG0628@2|Bacteria,1MVX7@1224|Proteobacteria,42S7F@68525|delta/epsilon subdivisions,2WK0P@28221|Deltaproteobacteria,2MS10@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Pfam:UPF0118	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
HKD2_k127_4305045_6	1349767.GJA_3067	2.338e-31	130.0	COG0251@1|root,COG0251@2|Bacteria,1RD3E@1224|Proteobacteria,2VV2Q@28216|Betaproteobacteria	28216|Betaproteobacteria	J	Endoribonuclease L-PSP	-	-	-	-	-	-	-	-	-	-	-	-	Ribonuc_L-PSP
HKD2_k127_4305045_2	493475.GARC_4235	1.252e-126	429.0	COG3356@1|root,COG3356@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Ceramidase_alk
HKD2_k127_4321051_12	247634.GPB2148_2913	5.293e-78	268.0	COG1454@1|root,COG1454@2|Bacteria,1MVPH@1224|Proteobacteria,1RMVU@1236|Gammaproteobacteria,1J61R@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	COG1454 Alcohol dehydrogenase, class IV	-	-	-	-	-	-	-	-	-	-	-	-	Fe-ADH
HKD2_k127_4321051_2	247633.GP2143_07964	4.307e-203	646.0	COG0318@1|root,COG0318@2|Bacteria,1MUMC@1224|Proteobacteria,1RMGS@1236|Gammaproteobacteria,1J5JZ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	IQ	COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II	alkK	-	6.2.1.44	ko:K20034	ko00920,map00920	-	R10820	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C
HKD2_k127_4321051_19	1234364.AMSF01000002_gene2314	1.059e-25	115.0	COG0457@1|root,COG3710@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1S720@1236|Gammaproteobacteria,1X954@135614|Xanthomonadales	135614|Xanthomonadales	K	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Trans_reg_C
HKD2_k127_4321051_7	700598.Niako_4254	6.673e-127	424.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	GSDH,Phage-tail_3,TIG
HKD2_k127_4321051_21	314285.KT71_04360	0.0001477	46.0	2DB8N@1|root,2Z7S9@2|Bacteria,1PZ8J@1224|Proteobacteria,1S1F6@1236|Gammaproteobacteria,1J5YW@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function (DUF3047)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3047
HKD2_k127_4321051_14	351348.Maqu_3067	5.696e-57	217.0	COG1020@1|root,COG1020@2|Bacteria,1N7HY@1224|Proteobacteria,1RQJX@1236|Gammaproteobacteria,464B6@72275|Alteromonadaceae	1236|Gammaproteobacteria	Q	COG1020 Non-ribosomal peptide synthetase modules and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	DUF1298,WES_acyltransf
HKD2_k127_4321051_22	1268303.RHODMAR_1830	0.0003502	49.0	COG3832@1|root,COG3832@2|Bacteria,2IH5A@201174|Actinobacteria,4G35U@85025|Nocardiaceae	201174|Actinobacteria	S	Protein of unknown function (DUF2505)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2505
HKD2_k127_4321051_17	1168059.KB899087_gene3104	1.552e-45	178.0	COG3932@1|root,COG3932@2|Bacteria,1MZD5@1224|Proteobacteria,2U77X@28211|Alphaproteobacteria,3F0WY@335928|Xanthobacteraceae	28211|Alphaproteobacteria	S	Exopolysaccharide synthesis, ExoD	exoD	-	-	-	-	-	-	-	-	-	-	-	ExoD
HKD2_k127_4321051_4	448385.sce4900	2.894e-151	484.0	COG1064@1|root,COG1064@2|Bacteria,1MUTT@1224|Proteobacteria,42MY6@68525|delta/epsilon subdivisions,2WMDC@28221|Deltaproteobacteria,2YU5V@29|Myxococcales	28221|Deltaproteobacteria	C	Alcohol dehydrogenase GroES-like domain	-	-	1.1.1.1	ko:K13953	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
HKD2_k127_4321051_15	439235.Dalk_1399	1.293e-56	211.0	COG4221@1|root,COG4221@2|Bacteria,1R08W@1224|Proteobacteria,43CRM@68525|delta/epsilon subdivisions	1224|Proteobacteria	S	Polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HKD2_k127_4321051_8	316055.RPE_3197	1.078e-124	410.0	COG0451@1|root,COG0451@2|Bacteria,1N8PG@1224|Proteobacteria,2U1A9@28211|Alphaproteobacteria,3JXC0@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	M	Polysaccharide biosynthesis protein	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
HKD2_k127_4321051_10	316055.RPE_3198	5.118e-92	328.0	COG0385@1|root,COG0385@2|Bacteria,1MXF3@1224|Proteobacteria,2U2YW@28211|Alphaproteobacteria,3JYK9@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	SBF-like CPA transporter family (DUF4137)	-	-	-	ko:K03453	-	-	-	-	ko00000	2.A.28	-	-	SBF
HKD2_k127_4321051_1	1002809.SSIL_2408	2.062e-234	738.0	COG0028@1|root,COG0028@2|Bacteria,1TQE8@1239|Firmicutes,4H9VR@91061|Bacilli,26DUZ@186818|Planococcaceae	91061|Bacilli	E	COG0028 Thiamine pyrophosphate-requiring enzymes acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
HKD2_k127_4321051_13	1030157.AFMP01000040_gene1562	1.267e-74	261.0	COG0730@1|root,COG0730@2|Bacteria,1R3V4@1224|Proteobacteria,2TRYX@28211|Alphaproteobacteria,2K204@204457|Sphingomonadales	204457|Sphingomonadales	S	membrane transporter protein	-	-	-	-	-	-	-	-	-	-	-	-	TauE
HKD2_k127_4321051_16	13690.CP98_01765	7.174e-55	202.0	COG4798@1|root,COG4798@2|Bacteria,1RHGZ@1224|Proteobacteria,2U7R8@28211|Alphaproteobacteria,2KDKG@204457|Sphingomonadales	204457|Sphingomonadales	S	Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4321051_11	886293.Sinac_5242	3.344e-85	289.0	2C3PP@1|root,2Z954@2|Bacteria,2J2AE@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4321051_5	886293.Sinac_5243	5.949e-140	449.0	COG0115@1|root,COG0115@2|Bacteria,2J2GT@203682|Planctomycetes	203682|Planctomycetes	H	Branched-chain amino acid aminotransferase 4-amino-4-deoxychorismate lyase	-	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
HKD2_k127_4321051_9	1454004.AW11_00884	5.804e-100	340.0	COG2378@1|root,COG2378@2|Bacteria,1P2ZE@1224|Proteobacteria,2VMDI@28216|Betaproteobacteria,1KQ7Z@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	K	WYL domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_11,WYL
HKD2_k127_4321051_3	448385.sce5468	1.432e-186	599.0	COG0475@1|root,COG1226@1|root,COG0475@2|Bacteria,COG1226@2|Bacteria,1MV34@1224|Proteobacteria,42MEM@68525|delta/epsilon subdivisions,2WKYA@28221|Deltaproteobacteria,2YU1C@29|Myxococcales	28221|Deltaproteobacteria	P	Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family	kefB	-	-	ko:K03455,ko:K11745,ko:K11747	-	-	-	-	ko00000,ko02000	2.A.37,2.A.37.1.1,2.A.37.1.2	-	-	Na_H_Exchanger,TrkA_N
HKD2_k127_4321051_6	794903.OPIT5_18365	3.604e-137	455.0	COG0366@1|root,COG0366@2|Bacteria,46W69@74201|Verrucomicrobia,3K94Z@414999|Opitutae	414999|Opitutae	G	Alpha-amylase domain	-	-	3.2.1.1	ko:K01176	ko00500,ko01100,ko04973,map00500,map01100,map04973	-	R02108,R02112,R11262	-	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase
HKD2_k127_4321051_0	1384054.N790_09885	0.0	1062.0	COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,1RN05@1236|Gammaproteobacteria,1X39C@135614|Xanthomonadales	135614|Xanthomonadales	S	Peptidase M16	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
HKD2_k127_4321051_18	94624.Bpet0151	7.392e-42	167.0	COG3047@1|root,COG3047@2|Bacteria,1NUZJ@1224|Proteobacteria,2VS6T@28216|Betaproteobacteria,3T2EP@506|Alcaligenaceae	28216|Betaproteobacteria	M	OmpW family	ompW	GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944	-	ko:K07275	-	-	-	-	ko00000	-	-	-	OmpW
HKD2_k127_4321051_20	1461577.CCMH01000045_gene835	1.673e-05	56.0	COG2885@1|root,COG3637@1|root,COG2885@2|Bacteria,COG3637@2|Bacteria,4NIV8@976|Bacteroidetes,1HYGM@117743|Flavobacteriia	976|Bacteroidetes	M	Belongs to the ompA family	-	-	-	ko:K03286	-	-	-	-	ko00000,ko02000	1.B.6	-	-	OmpA
HKD2_k127_4350851_1	1123269.NX02_25980	7.062e-36	149.0	COG3577@1|root,COG3577@2|Bacteria,1MYAD@1224|Proteobacteria,2U8U8@28211|Alphaproteobacteria,2KCU8@204457|Sphingomonadales	204457|Sphingomonadales	S	gag-polyprotein putative aspartyl protease	-	-	-	-	-	-	-	-	-	-	-	-	Asp_protease_2
HKD2_k127_4350851_0	1381123.AYOD01000005_gene1218	4.706e-117	384.0	COG0646@1|root,COG0646@2|Bacteria,1NPFY@1224|Proteobacteria,2UJRS@28211|Alphaproteobacteria,43GPP@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	Catalyzes the formation of methionine from L-homocysteine and S-adenosyl-L-methionine	yitJ	-	2.1.1.13,2.1.1.5	ko:K00544,ko:K00548	ko00260,ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00260,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R02821,R09365	RC00035,RC00113,RC00496,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	S-methyl_trans
HKD2_k127_4401066_4	1384054.N790_12970	1.691e-55	215.0	COG4775@1|root,COG4775@2|Bacteria,1PT0R@1224|Proteobacteria,1RPWY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	COG4775 Outer membrane protein protective antigen OMA87	-	-	-	-	-	-	-	-	-	-	-	-	Bac_surface_Ag,ShlB
HKD2_k127_4401066_2	713586.KB900536_gene841	3.877e-130	424.0	COG0604@1|root,COG0604@2|Bacteria,1MWBD@1224|Proteobacteria,1RPCQ@1236|Gammaproteobacteria,1X2AC@135613|Chromatiales	135613|Chromatiales	C	N-terminal domain of oxidoreductase	-	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
HKD2_k127_4401066_6	1128421.JAGA01000003_gene2807	3.131e-33	133.0	COG3411@1|root,COG3411@2|Bacteria	2|Bacteria	C	Ferredoxin	-	-	6.6.1.2	ko:K02230	ko00860,ko01100,map00860,map01100	-	R05227	RC02000	ko00000,ko00001,ko01000	-	-	-	-
HKD2_k127_4401066_5	715451.ambt_16330	2.257e-50	181.0	COG0347@1|root,COG0347@2|Bacteria,1RGWK@1224|Proteobacteria,1S67I@1236|Gammaproteobacteria,467D0@72275|Alteromonadaceae	1236|Gammaproteobacteria	K	Belongs to the P(II) protein family	glnK	GO:0003674,GO:0005488,GO:0005515,GO:0006808,GO:0008150,GO:0042802,GO:0045848,GO:0048518,GO:0050789,GO:0065007	-	ko:K04752	-	-	-	-	ko00000	-	-	-	P-II
HKD2_k127_4401066_1	296591.Bpro_5300	1.092e-135	445.0	COG0446@1|root,COG0446@2|Bacteria,1NR3M@1224|Proteobacteria,2VJSV@28216|Betaproteobacteria,4AAZZ@80864|Comamonadaceae	28216|Betaproteobacteria	O	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	1.18.1.3	ko:K00529	ko00071,ko00360,ko01120,ko01220,map00071,map00360,map01120,map01220	M00545	R02000,R06782,R06783	RC00098	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	AIF_C,Pyr_redox_2,Reductase_C
HKD2_k127_4401066_0	1234364.AMSF01000016_gene1486	1.064e-184	594.0	COG3243@1|root,COG3243@2|Bacteria,1MU68@1224|Proteobacteria,1RPVQ@1236|Gammaproteobacteria,1X53T@135614|Xanthomonadales	135614|Xanthomonadales	I	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus	-	-	-	ko:K03821	ko00650,map00650	-	R04254	RC00004	ko00000,ko00001,ko01000	-	-	-	PHBC_N,PhaC_N
HKD2_k127_4401066_3	1385517.N800_09905	5.819e-111	369.0	COG0842@1|root,COG0842@2|Bacteria,1MW5R@1224|Proteobacteria,1RPB4@1236|Gammaproteobacteria,1X3TB@135614|Xanthomonadales	135614|Xanthomonadales	V	Transport permease protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
HKD2_k127_4401066_7	435908.IDSA_03870	1.791e-05	49.0	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,1RMM4@1236|Gammaproteobacteria,2QG7H@267893|Idiomarinaceae	1236|Gammaproteobacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	ybhF	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD2_k127_4402620_2	301.JNHE01000044_gene3840	4.056e-144	483.0	COG1502@1|root,COG1502@2|Bacteria,1MUDJ@1224|Proteobacteria,1RMIF@1236|Gammaproteobacteria,1YD4C@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	I	Phospholipase D. Active site motifs.	-	-	-	ko:K06132	ko00564,ko01100,map00564,map01100	-	R11062	RC00017	ko00000,ko00001,ko01000	-	-	-	PLDc_2
HKD2_k127_4402620_0	1121022.ABENE_19485	1.424e-184	586.0	COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,2TTYC@28211|Alphaproteobacteria,2KF9Q@204458|Caulobacterales	204458|Caulobacterales	Q	PFAM Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
HKD2_k127_4402620_5	1535422.ND16A_3506	1.81e-05	55.0	COG3210@1|root,COG3637@1|root,COG5184@1|root,COG3210@2|Bacteria,COG3637@2|Bacteria,COG5184@2|Bacteria,1QUXB@1224|Proteobacteria	1224|Proteobacteria	U	6-phosphogluconolactonase activity	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Big_3_2,Cadherin_3,Calx-beta,DUF4347,FecR,He_PIG
HKD2_k127_4402620_1	1381123.AYOD01000054_gene392	3.586e-146	480.0	COG5598@1|root,COG5598@2|Bacteria,1R7R2@1224|Proteobacteria,2TUNM@28211|Alphaproteobacteria,43NQG@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	H	Trimethylamine methyltransferase (MTTB)	-	-	2.1.1.250	ko:K14083	ko00680,ko01120,ko01200,map00680,map01120,map01200	M00563	R09124,R10016	RC00035,RC00732,RC01144,RC02984	ko00000,ko00001,ko00002,ko01000	-	-	-	MTTB
HKD2_k127_4402620_3	1502851.FG93_05927	6.199e-59	214.0	COG3221@1|root,COG3221@2|Bacteria,1QJET@1224|Proteobacteria,2TRTB@28211|Alphaproteobacteria,3JZ0G@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	ABC transporter, phosphonate, periplasmic substrate-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	Phosphonate-bd
HKD2_k127_4402620_4	1101190.ARWB01000001_gene3905	5.214e-22	96.0	COG3239@1|root,COG3239@2|Bacteria,1MXA8@1224|Proteobacteria,2TUQG@28211|Alphaproteobacteria,36ZZG@31993|Methylocystaceae	28211|Alphaproteobacteria	I	Fatty acid desaturase	-	-	-	-	-	-	-	-	-	-	-	-	FA_desaturase
HKD2_k127_4420226_0	748658.KB907313_gene2178	3.872e-113	381.0	COG0544@1|root,COG0544@2|Bacteria,1MUJP@1224|Proteobacteria,1RNZE@1236|Gammaproteobacteria,1WWKF@135613|Chromatiales	135613|Chromatiales	O	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase	tig	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03545	-	-	-	-	ko00000	-	-	-	FKBP_C,Trigger_C,Trigger_N
HKD2_k127_4420226_1	765910.MARPU_03380	2.658e-101	332.0	COG0740@1|root,COG0740@2|Bacteria,1MV46@1224|Proteobacteria,1RNR6@1236|Gammaproteobacteria,1WW24@135613|Chromatiales	135613|Chromatiales	OU	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins	clpP	-	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	CLP_protease
HKD2_k127_4420226_2	713586.KB900536_gene2994	1.45e-77	262.0	COG1219@1|root,COG1219@2|Bacteria,1MVQK@1224|Proteobacteria,1RN9N@1236|Gammaproteobacteria,1WX82@135613|Chromatiales	135613|Chromatiales	O	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP	clpX	-	-	ko:K03544	ko04112,map04112	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA_2,ClpB_D2-small,zf-C4_ClpX
HKD2_k127_44514_3	326427.Cagg_0822	5.224e-38	165.0	2DM58@1|root,31S4C@2|Bacteria,2GBK4@200795|Chloroflexi,376UX@32061|Chloroflexia	32061|Chloroflexia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_44514_0	59538.XP_005970412.1	3.681e-195	621.0	COG0624@1|root,KOG2275@2759|Eukaryota,39RWD@33154|Opisthokonta,3BEKC@33208|Metazoa,3CSZJ@33213|Bilateria,4818N@7711|Chordata,493PC@7742|Vertebrata,3J52B@40674|Mammalia,4IYI2@91561|Cetartiodactyla	33208|Metazoa	E	Carboxypeptidase	-	-	-	ko:K13049	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20
HKD2_k127_44514_1	566466.NOR53_3522	1.937e-183	598.0	COG0457@1|root,COG0457@2|Bacteria,1MYQU@1224|Proteobacteria,1RWMR@1236|Gammaproteobacteria,1JABK@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	K	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_12,TPR_7
HKD2_k127_44514_2	1163409.UUA_01295	1.214e-131	439.0	COG0758@1|root,COG0758@2|Bacteria,1N2UI@1224|Proteobacteria,1SEVM@1236|Gammaproteobacteria,1X3XH@135614|Xanthomonadales	135614|Xanthomonadales	LU	DNA mediated transformation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4498055_7	1174684.EBMC1_14450	1.177e-64	228.0	COG1446@1|root,COG4242@1|root,COG1446@2|Bacteria,COG4242@2|Bacteria,1MWFC@1224|Proteobacteria,2TU8K@28211|Alphaproteobacteria,2K0JU@204457|Sphingomonadales	204457|Sphingomonadales	E	Asparaginase	-	-	3.4.19.5	ko:K13051	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Asparaginase_2,Peptidase_S51
HKD2_k127_4498055_0	1150626.PHAMO_280061	0.0	1572.0	COG1038@1|root,COG1038@2|Bacteria,1NW9R@1224|Proteobacteria,2TQXU@28211|Alphaproteobacteria,2JQHD@204441|Rhodospirillales	204441|Rhodospirillales	C	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second	-	-	6.4.1.1	ko:K01958	ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230	M00173	R00344	RC00040,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2,HMGL-like,PYC_OADA
HKD2_k127_4498055_1	1348657.M622_06235	7.523e-156	502.0	COG0477@1|root,COG2814@2|Bacteria,1NE49@1224|Proteobacteria,2VNGV@28216|Betaproteobacteria,2KVR8@206389|Rhodocyclales	206389|Rhodocyclales	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD2_k127_4498055_6	640081.Dsui_1139	1.35e-67	240.0	COG4275@1|root,COG4275@2|Bacteria,1MYDE@1224|Proteobacteria,2VQ0S@28216|Betaproteobacteria,2KYFQ@206389|Rhodocyclales	206389|Rhodocyclales	S	Chromate resistance exported protein	-	-	-	-	-	-	-	-	-	-	-	-	Chrome_Resist
HKD2_k127_4498055_8	1248760.ANFZ01000009_gene1382	1.515e-59	214.0	COG0605@1|root,COG0605@2|Bacteria,1R4Z3@1224|Proteobacteria,2U38P@28211|Alphaproteobacteria,2K37I@204457|Sphingomonadales	204457|Sphingomonadales	P	Iron/manganese superoxide dismutases, C-terminal domain	-	-	1.15.1.1	ko:K04564	ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016	-	-	-	ko00000,ko00001,ko01000	-	-	-	Sod_Fe_C
HKD2_k127_4498055_9	580332.Slit_2205	2.71e-55	199.0	COG3118@1|root,COG3118@2|Bacteria,1RHUA@1224|Proteobacteria,2VR2G@28216|Betaproteobacteria,44VT6@713636|Nitrosomonadales	28216|Betaproteobacteria	O	Thioredoxin	trxC	-	1.8.1.8	ko:K03672	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Thioredoxin
HKD2_k127_4498055_2	1049564.TevJSym_af00130	7.151e-117	386.0	COG0484@1|root,COG0484@2|Bacteria,1MUZ4@1224|Proteobacteria,1RP09@1236|Gammaproteobacteria,1J5VE@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	O	DnaJ-class molecular chaperone	cbpA	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0097159,GO:1901363	-	ko:K05516	-	-	-	-	ko00000,ko03036,ko03110	-	-	-	DnaJ,DnaJ_C
HKD2_k127_4498055_12	1342301.JASD01000008_gene1158	7.118e-18	87.0	COG0789@1|root,COG0789@2|Bacteria,1N9MT@1224|Proteobacteria,2UFSF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	MerR HTH family regulatory protein	-	-	-	ko:K18997	-	-	-	-	ko00000,ko03036	-	-	-	MerR_2
HKD2_k127_4498055_3	1384056.N787_12415	1.796e-116	384.0	COG1814@1|root,COG1814@2|Bacteria,1MUZE@1224|Proteobacteria,1S2G7@1236|Gammaproteobacteria,1X61U@135614|Xanthomonadales	135614|Xanthomonadales	S	VIT family	-	-	-	-	-	-	-	-	-	-	-	-	VIT1
HKD2_k127_4498055_11	1408419.JHYG01000030_gene1259	3.256e-24	107.0	COG0642@1|root,COG1352@1|root,COG2201@1|root,COG4566@1|root,COG1352@2|Bacteria,COG2201@2|Bacteria,COG2205@2|Bacteria,COG4566@2|Bacteria,1NRP8@1224|Proteobacteria,2TWP9@28211|Alphaproteobacteria,2JYV4@204441|Rhodospirillales	204441|Rhodospirillales	T	Protein-glutamate methylesterase	-	-	2.1.1.80,3.1.1.61	ko:K13924	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest,CheR,CheR_N,GerE,HATPase_c,HisKA,PAS_10,Response_reg
HKD2_k127_4498055_5	1027273.GZ77_15620	2.051e-80	272.0	COG4566@1|root,COG4566@2|Bacteria,1N6WR@1224|Proteobacteria,1S0TV@1236|Gammaproteobacteria,1XJ7K@135619|Oceanospirillales	135619|Oceanospirillales	T	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HKD2_k127_4498055_4	1123256.KB907927_gene1762	5.162e-104	361.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,1RR5W@1236|Gammaproteobacteria,1X7AW@135614|Xanthomonadales	135614|Xanthomonadales	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_8
HKD2_k127_4498055_10	330214.NIDE3859	2.16e-32	133.0	COG0071@1|root,COG0071@2|Bacteria,3J0TV@40117|Nitrospirae	40117|Nitrospirae	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
HKD2_k127_4498055_13	1415780.JPOG01000001_gene2435	8.167e-16	81.0	COG2836@1|root,COG2836@2|Bacteria,1RIGJ@1224|Proteobacteria,1S5V1@1236|Gammaproteobacteria,1X66I@135614|Xanthomonadales	135614|Xanthomonadales	S	Cytochrome C biogenesis protein transmembrane region	-	-	-	ko:K09792	-	-	-	-	ko00000	-	-	-	DsbD_2
HKD2_k127_4499123_5	279238.Saro_2863	7.218e-52	187.0	COG0346@1|root,COG0346@2|Bacteria,1N4DA@1224|Proteobacteria,2UEPZ@28211|Alphaproteobacteria,2K534@204457|Sphingomonadales	204457|Sphingomonadales	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HKD2_k127_4499123_0	279238.Saro_2861	5.962e-277	854.0	COG0404@1|root,COG0404@2|Bacteria,1MWZS@1224|Proteobacteria,2TSVD@28211|Alphaproteobacteria,2K1VS@204457|Sphingomonadales	204457|Sphingomonadales	E	Aminomethyltransferase folate-binding domain	-	-	2.1.1.341	ko:K15066	ko00627,ko01120,map00627,map01120	-	R09271,R10136	RC00113,RC00392	ko00000,ko00001,ko01000	-	-	-	GCV_T,GCV_T_C
HKD2_k127_4499123_3	279238.Saro_1864	7.162e-138	450.0	COG0604@1|root,COG0604@2|Bacteria,1MXUX@1224|Proteobacteria,2TTWF@28211|Alphaproteobacteria,2K2II@204457|Sphingomonadales	204457|Sphingomonadales	C	COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
HKD2_k127_4499123_2	279238.Saro_2868	3.615e-168	531.0	COG2159@1|root,COG2159@2|Bacteria,1MUUR@1224|Proteobacteria,2TSQB@28211|Alphaproteobacteria,2K2FP@204457|Sphingomonadales	204457|Sphingomonadales	S	Amidohydrolase	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
HKD2_k127_4499123_4	627192.SLG_06490	1.632e-82	288.0	COG0647@1|root,COG0647@2|Bacteria,1QGX4@1224|Proteobacteria,2U834@28211|Alphaproteobacteria,2K8P7@204457|Sphingomonadales	204457|Sphingomonadales	G	Haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_6,Hydrolase_like
HKD2_k127_4499123_1	627192.SLG_06500	1.193e-220	692.0	COG5016@1|root,COG5016@2|Bacteria,1QTTG@1224|Proteobacteria,2TT4W@28211|Alphaproteobacteria,2K9IS@204457|Sphingomonadales	204457|Sphingomonadales	C	Conserved carboxylase domain	-	-	4.1.1.3	ko:K01571	ko00620,ko01100,map00620,map01100	-	R00217	RC00040	ko00000,ko00001,ko01000,ko02000	3.B.1.1.1	-	-	HMGL-like,PYC_OADA
HKD2_k127_4660898_3	452637.Oter_1466	1.45e-160	510.0	COG0243@1|root,COG0243@2|Bacteria,46U1H@74201|Verrucomicrobia	74201|Verrucomicrobia	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	1.8.5.5	ko:K08352	ko00920,ko01120,map00920,map01120	-	R10149	RC02823	ko00000,ko00001,ko01000,ko02000	5.A.3.5	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
HKD2_k127_4660898_7	1191523.MROS_1775	1.3e-92	306.0	COG0437@1|root,COG0437@2|Bacteria	2|Bacteria	C	4 iron, 4 sulfur cluster binding	nrfC	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0008150,GO:0008152,GO:0016491,GO:0016661,GO:0016662,GO:0030288,GO:0030313,GO:0031975,GO:0042279,GO:0042597,GO:0044464,GO:0055114,GO:0098809	-	ko:K04014,ko:K08353,ko:K08358,ko:K16293	ko00920,ko01120,ko02020,map00920,map01120,map02020	-	R10149,R10150	RC02823,RC03109	ko00000,ko00001,ko02000	5.A.3.10,5.A.3.5	-	iUMNK88_1353.UMNK88_4933	Fer4,Fer4_11,Fer4_3,Fer4_4
HKD2_k127_4660898_8	1191523.MROS_1776	7.978e-90	306.0	COG3301@1|root,COG3301@2|Bacteria	2|Bacteria	P	Polysulphide reductase, NrfD	-	-	-	-	-	-	-	-	-	-	-	-	NrfD,NrfD_2
HKD2_k127_4660898_12	945713.IALB_1660	1.611e-63	223.0	COG2391@1|root,COG2391@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K07112	-	-	-	-	ko00000	-	-	-	Sulf_transp
HKD2_k127_4660898_11	1191523.MROS_1778	6.159e-69	247.0	COG0607@1|root,COG2391@1|root,COG0607@2|Bacteria,COG2391@2|Bacteria	2|Bacteria	P	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS	ygaP	-	-	ko:K07112	-	-	-	-	ko00000	-	-	-	DUF2892,Rhodanese,Sulf_transp
HKD2_k127_4660898_15	452637.Oter_1462	1.214e-38	153.0	COG0607@1|root,COG2391@1|root,COG0607@2|Bacteria,COG2391@2|Bacteria	2|Bacteria	P	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS	-	-	2.8.1.1,2.8.1.2	ko:K00406,ko:K01011,ko:K07112	ko00190,ko00270,ko00920,ko01100,ko01120,ko02020,ko04122,map00190,map00270,map00920,map01100,map01120,map02020,map04122	M00156	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	PALP,Rhodanese,Sulf_transp
HKD2_k127_4660898_17	279714.FuraDRAFT_3796	6.486e-21	95.0	COG2010@1|root,COG2010@2|Bacteria,1NJ3U@1224|Proteobacteria,2VYBQ@28216|Betaproteobacteria	28216|Betaproteobacteria	C	cytochrome C oxidoreductase subunit B	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4660898_1	748280.NH8B_0017	1.292e-171	547.0	COG2041@1|root,COG2041@2|Bacteria,1MX9E@1224|Proteobacteria,2VK72@28216|Betaproteobacteria,2KSEM@206351|Neisseriales	206351|Neisseriales	C	Mo-co oxidoreductase dimerisation domain	sorA	-	-	-	-	-	-	-	-	-	-	-	Mo-co_dimer,Oxidored_molyb
HKD2_k127_4660898_9	1273538.G159_17110	1.034e-81	284.0	COG2855@1|root,COG2855@2|Bacteria,1TQYA@1239|Firmicutes,4HCCP@91061|Bacilli,26FJQ@186818|Planococcaceae	91061|Bacilli	S	Conserved hypothetical protein 698	-	-	-	-	-	-	-	-	-	-	-	-	Cons_hypoth698
HKD2_k127_4660898_5	314285.KT71_03492	1.756e-123	411.0	COG2067@1|root,COG2067@2|Bacteria,1MV7W@1224|Proteobacteria,1RPTU@1236|Gammaproteobacteria,1J804@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	I	Outer membrane protein transport protein (OMPP1/FadL/TodX)	-	-	-	ko:K06076	-	-	-	-	ko00000,ko02000	1.B.9	-	-	Toluene_X
HKD2_k127_4660898_16	648757.Rvan_0606	1.348e-23	110.0	COG0425@1|root,COG0425@2|Bacteria,1MZA5@1224|Proteobacteria,2UF3C@28211|Alphaproteobacteria,3N7C7@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	O	Belongs to the sulfur carrier protein TusA family	tusA	-	-	ko:K04085	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	TusA
HKD2_k127_4660898_10	648757.Rvan_0605	7.957e-73	249.0	COG2210@1|root,COG2210@2|Bacteria,1RDUG@1224|Proteobacteria,2U6FZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	DsrE/DsrF/DrsH-like family	-	-	-	-	-	-	-	-	-	-	-	-	DrsE_2
HKD2_k127_4660898_4	371731.Rsw2DRAFT_1856	2.378e-125	412.0	COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,2TRGU@28211|Alphaproteobacteria,1FCJZ@1060|Rhodobacter	28211|Alphaproteobacteria	BQ	PFAM Histone deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
HKD2_k127_4660898_2	1417296.U879_08050	7.856e-164	527.0	COG1856@1|root,COG1856@2|Bacteria,1R6PW@1224|Proteobacteria,2U1YU@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Radical SAM	-	-	-	ko:K09711	-	-	-	-	ko00000	-	-	-	Radical_SAM
HKD2_k127_4660898_0	582899.Hden_0685	8.491e-214	672.0	COG2516@1|root,COG2516@2|Bacteria,1MWZQ@1224|Proteobacteria,2U4HP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Radical SAM	-	-	2.8.1.6	ko:K01012	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R01078	RC00441	ko00000,ko00001,ko00002,ko01000	-	-	-	Radical_SAM
HKD2_k127_4660898_6	1417296.U879_08035	3.603e-111	369.0	COG0095@1|root,COG0095@2|Bacteria,1N1T8@1224|Proteobacteria,2U1PC@28211|Alphaproteobacteria	28211|Alphaproteobacteria	H	biotin lipoate A B protein ligase	-	-	6.3.1.20	ko:K03800	ko00785,ko01100,map00785,map01100	-	R07770,R07771,R11143	RC00043,RC00070,RC00090,RC00992,RC02896	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB
HKD2_k127_4660898_14	582899.Hden_0687	1.255e-60	221.0	COG0518@1|root,COG0518@2|Bacteria,1MYXC@1224|Proteobacteria,2UBE9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	F	GMP synthase (glutamine-hydrolyzing) activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4660898_13	582899.Hden_0688	5.683e-63	218.0	COG2044@1|root,COG2044@2|Bacteria,1RGWS@1224|Proteobacteria,2UB97@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	DsrE/DsrF/DrsH-like family	-	-	-	-	-	-	-	-	-	-	-	-	DrsE_2
HKD2_k127_468964_17	1122603.ATVI01000013_gene1318	1.504e-73	252.0	COG0725@1|root,COG0725@2|Bacteria,1MVNA@1224|Proteobacteria,1RN71@1236|Gammaproteobacteria,1X6RU@135614|Xanthomonadales	135614|Xanthomonadales	P	ABC-type molybdate transport system periplasmic component	modA	GO:0003674,GO:0005488,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0015689,GO:0015698,GO:0030973,GO:0043167,GO:0043168,GO:0051179,GO:0051234,GO:1901359	-	ko:K02020	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.8	-	-	SBP_bac_11
HKD2_k127_468964_13	1122603.ATVI01000013_gene1317	8.037e-110	361.0	COG4149@1|root,COG4149@2|Bacteria,1MUXR@1224|Proteobacteria,1RRDV@1236|Gammaproteobacteria,1X5DM@135614|Xanthomonadales	135614|Xanthomonadales	P	abc transporter, permease	modB	-	-	ko:K02018	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.8	-	-	BPD_transp_1
HKD2_k127_468964_15	1122603.ATVI01000013_gene1316	2.593e-83	282.0	COG4148@1|root,COG4148@2|Bacteria,1MU8K@1224|Proteobacteria,1RQCV@1236|Gammaproteobacteria,1X6W6@135614|Xanthomonadales	135614|Xanthomonadales	P	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system	modC	-	3.6.3.29	ko:K02017	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.8	-	-	ABC_tran,TOBE
HKD2_k127_468964_19	1366050.N234_03375	2.297e-68	241.0	COG2005@1|root,COG3585@1|root,COG2005@2|Bacteria,COG3585@2|Bacteria,1P9SX@1224|Proteobacteria,2VMCH@28216|Betaproteobacteria,1K2CT@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Transcriptional regulator	modE	-	-	ko:K02019	-	-	-	-	ko00000,ko03000	-	-	-	HTH_1,TOBE
HKD2_k127_468964_8	631362.Thi970DRAFT_02987	1.544e-140	467.0	COG0038@1|root,COG0038@2|Bacteria,1MV4K@1224|Proteobacteria,1RQZQ@1236|Gammaproteobacteria,1WXQ3@135613|Chromatiales	135613|Chromatiales	P	FimV N-terminal domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Voltage_CLC
HKD2_k127_468964_14	311402.Avi_2831	7.736e-99	330.0	COG0581@1|root,COG0581@2|Bacteria,1MUWB@1224|Proteobacteria,2TQYQ@28211|Alphaproteobacteria,4BCJY@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	pstA	GO:0003674,GO:0005215,GO:0005315,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0010921,GO:0015291,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0019220,GO:0019222,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0031323,GO:0033554,GO:0034220,GO:0035303,GO:0035435,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051174,GO:0051179,GO:0051234,GO:0051336,GO:0051716,GO:0055085,GO:0065007,GO:0065009,GO:0071944,GO:0098656,GO:0098660,GO:0098661	-	ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
HKD2_k127_468964_10	1187851.A33M_3704	1.505e-124	406.0	COG0573@1|root,COG0573@2|Bacteria,1MVKP@1224|Proteobacteria,2TQU1@28211|Alphaproteobacteria,3FDA6@34008|Rhodovulum	28211|Alphaproteobacteria	U	probably responsible for the translocation of the substrate across the membrane	pstC	-	-	ko:K02037	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
HKD2_k127_468964_9	1380391.JIAS01000013_gene3644	4.722e-137	447.0	COG0226@1|root,COG0226@2|Bacteria,1MUAZ@1224|Proteobacteria,2TTJA@28211|Alphaproteobacteria,2JV0W@204441|Rhodospirillales	204441|Rhodospirillales	P	Part of the ABC transporter complex PstSACB involved in phosphate import	-	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
HKD2_k127_468964_24	1123377.AUIV01000021_gene2532	6.419e-15	78.0	COG2608@1|root,COG2608@2|Bacteria,1NGBD@1224|Proteobacteria,1SGGE@1236|Gammaproteobacteria,1X93V@135614|Xanthomonadales	135614|Xanthomonadales	P	Heavy-metal-associated domain	-	-	-	ko:K07213	ko04978,map04978	-	-	-	ko00000,ko00001	-	-	-	HMA
HKD2_k127_468964_2	1385515.N791_05555	2.423e-276	868.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,1RN2C@1236|Gammaproteobacteria,1X3GA@135614|Xanthomonadales	135614|Xanthomonadales	P	Heavy metal translocating P-type atpase	-	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
HKD2_k127_468964_20	913325.N799_00885	7.439e-62	215.0	COG0789@1|root,COG0789@2|Bacteria,1RGX6@1224|Proteobacteria,1S8ZG@1236|Gammaproteobacteria,1X6V1@135614|Xanthomonadales	135614|Xanthomonadales	K	helix_turn_helix, mercury resistance	-	-	-	ko:K19591	-	M00769	-	-	ko00000,ko00002,ko01504,ko03000	-	-	-	MerR,MerR-DNA-bind
HKD2_k127_468964_11	351746.Pput_4528	4e-123	403.0	COG1230@1|root,COG1230@2|Bacteria,1MVQB@1224|Proteobacteria,1RMR8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	cation diffusion facilitator family transporter	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux
HKD2_k127_468964_3	991905.SL003B_2026	2.985e-229	722.0	COG4986@1|root,COG4986@2|Bacteria,1MV85@1224|Proteobacteria,2TTRP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
HKD2_k127_468964_6	991905.SL003B_2024	1.673e-189	602.0	COG1116@1|root,COG4754@1|root,COG1116@2|Bacteria,COG4754@2|Bacteria,1MUDV@1224|Proteobacteria,2TRXZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	ABC transporter	-	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	AAA_assoc_C,ABC_tran
HKD2_k127_468964_18	1121920.AUAU01000018_gene1785	1.627e-68	243.0	COG0671@1|root,COG0671@2|Bacteria,3Y90S@57723|Acidobacteria	57723|Acidobacteria	I	PAP2 superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PAP2_3
HKD2_k127_468964_12	1121920.AUAU01000018_gene1786	5.258e-114	375.0	COG0508@1|root,COG0508@2|Bacteria	2|Bacteria	C	S-acyltransferase activity	-	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh
HKD2_k127_468964_7	1452718.JBOY01000032_gene28	1.435e-184	587.0	COG1680@1|root,COG1680@2|Bacteria,1P3SQ@1224|Proteobacteria,1RRMI@1236|Gammaproteobacteria	1236|Gammaproteobacteria	V	COG1680 Beta-lactamase class C and other penicillin binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
HKD2_k127_468964_22	1523503.JPMY01000006_gene2275	2.722e-43	171.0	COG0583@1|root,COG0583@2|Bacteria,1RJXD@1224|Proteobacteria,1SBA9@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HKD2_k127_468964_1	622637.KE124774_gene1454	3.63e-283	876.0	COG3119@1|root,COG3119@2|Bacteria,1MUJH@1224|Proteobacteria,2TSB8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	arylsulfatase A	aslA	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase,Sulfatase_C
HKD2_k127_468964_4	469383.Cwoe_4226	2.404e-225	709.0	COG2303@1|root,COG2303@2|Bacteria,2GJ3J@201174|Actinobacteria,4CRRH@84995|Rubrobacteria	84995|Rubrobacteria	E	GMC oxidoreductase	-	-	1.1.3.6	ko:K03333	ko00984,ko01120,map00984,map01120	-	R01459	RC00146	ko00000,ko00001,ko01000	-	-	-	GMC_oxred_C,GMC_oxred_N
HKD2_k127_468964_0	298386.PBPRA1265	4.18e-306	951.0	COG2015@1|root,COG2015@2|Bacteria,1MU82@1224|Proteobacteria,1RMHR@1236|Gammaproteobacteria,1XUC7@135623|Vibrionales	135623|Vibrionales	Q	COG2015 Alkyl sulfatase and related hydrolases	-	-	-	ko:K01138	-	-	-	-	ko00000,ko01000	-	-	-	Alkyl_sulf_C,Alkyl_sulf_dimr,Lactamase_B
HKD2_k127_468964_21	1280949.HAD_07805	6.428e-57	202.0	COG0432@1|root,COG0432@2|Bacteria,1RH13@1224|Proteobacteria,2U945@28211|Alphaproteobacteria,43XUZ@69657|Hyphomonadaceae	28211|Alphaproteobacteria	S	Uncharacterised protein family UPF0047	-	-	-	-	-	-	-	-	-	-	-	-	UPF0047
HKD2_k127_468964_23	62928.azo1213	2.006e-20	102.0	COG4313@1|root,COG4313@2|Bacteria,1R58D@1224|Proteobacteria,2WFRB@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Putative MetA-pathway of phenol degradation	-	-	-	-	-	-	-	-	-	-	-	-	Phenol_MetA_deg
HKD2_k127_468964_5	926550.CLDAP_36720	4.579e-212	672.0	COG3961@1|root,COG3961@2|Bacteria,2G8R7@200795|Chloroflexi	200795|Chloroflexi	C	PFAM thiamine pyrophosphate protein TPP binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
HKD2_k127_4695341_2	1028307.EAE_19840	7.108e-124	403.0	COG2326@1|root,COG2326@2|Bacteria,1MVE2@1224|Proteobacteria,1RM9U@1236|Gammaproteobacteria,3X31V@547|Enterobacter	1236|Gammaproteobacteria	S	Polyphosphate kinase 2 (PPK2)	ppk2	-	2.7.4.1	ko:K22468	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PPK2
HKD2_k127_4695341_3	1419583.V466_02345	3.379e-30	126.0	COG1814@1|root,COG1814@2|Bacteria,1R469@1224|Proteobacteria	1224|Proteobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	VIT1
HKD2_k127_4695341_4	1366050.N234_22595	1.817e-05	49.0	COG1814@1|root,COG1814@2|Bacteria,1R469@1224|Proteobacteria,2W0Q1@28216|Betaproteobacteria,1K5B3@119060|Burkholderiaceae	28216|Betaproteobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	VIT1
HKD2_k127_4695341_0	1267534.KB906760_gene1237	6.863e-216	684.0	COG0659@1|root,COG0659@2|Bacteria,3Y6R7@57723|Acidobacteria,2JM1A@204432|Acidobacteriia	204432|Acidobacteriia	P	Sulfate permease family	-	-	-	-	-	-	-	-	-	-	-	-	STAS,Sulfate_transp
HKD2_k127_4695341_1	1379270.AUXF01000002_gene1286	6.015e-204	639.0	COG0166@1|root,COG0166@2|Bacteria,1ZU5D@142182|Gemmatimonadetes	142182|Gemmatimonadetes	G	Phosphoglucose isomerase	pgi	-	5.3.1.9	ko:K01810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114	R02739,R02740,R03321	RC00376,RC00563	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGI
HKD2_k127_4794241_0	391625.PPSIR1_22616	4.765e-167	537.0	COG3547@1|root,COG3547@2|Bacteria,1MUKH@1224|Proteobacteria,42NNJ@68525|delta/epsilon subdivisions,2WKP9@28221|Deltaproteobacteria,2Z0JD@29|Myxococcales	28221|Deltaproteobacteria	L	COG3547 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,DUF2924,Transposase_20
HKD2_k127_4794241_1	743299.Acife_1163	1.333e-36	145.0	COG3385@1|root,COG3385@2|Bacteria,1PJ6W@1224|Proteobacteria,1SW6A@1236|Gammaproteobacteria,2NDUM@225057|Acidithiobacillales	225057|Acidithiobacillales	L	transposase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_489551_1	204669.Acid345_4693	9.392e-103	343.0	COG1574@1|root,COG1574@2|Bacteria,3Y2UF@57723|Acidobacteria,2JIRH@204432|Acidobacteriia	57723|Acidobacteria	S	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
HKD2_k127_489551_8	1346791.M529_07045	3.67e-29	126.0	2919Q@1|root,2ZNWS@2|Bacteria,1NAF5@1224|Proteobacteria,2U3AC@28211|Alphaproteobacteria,2KEWN@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_489551_5	861299.J421_5905	3.8e-39	158.0	2AC8C@1|root,311T1@2|Bacteria,1ZU75@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_489551_3	1545915.JROG01000004_gene2569	3.094e-57	226.0	COG4774@1|root,COG4774@2|Bacteria,1NSNU@1224|Proteobacteria,2UR6B@28211|Alphaproteobacteria,2K91M@204457|Sphingomonadales	204457|Sphingomonadales	P	TonB dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
HKD2_k127_489551_7	338966.Ppro_3323	1.122e-32	140.0	COG0823@1|root,COG0823@2|Bacteria,1MV09@1224|Proteobacteria,42PHP@68525|delta/epsilon subdivisions,2WIXN@28221|Deltaproteobacteria,43UDK@69541|Desulfuromonadales	28221|Deltaproteobacteria	U	Involved in the TonB-independent uptake of proteins	tolB	GO:0003674,GO:0005215,GO:0006810,GO:0008150,GO:0019534,GO:0022857,GO:0051179,GO:0051234,GO:0055085,GO:1901998	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40,TolB_N
HKD2_k127_489551_4	1267535.KB906767_gene3662	1.288e-39	166.0	COG0457@1|root,COG3710@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria	2|Bacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Trans_reg_C
HKD2_k127_489551_6	240015.ACP_0484	1.101e-37	150.0	COG0607@1|root,COG0607@2|Bacteria,3Y58X@57723|Acidobacteria,2JK2A@204432|Acidobacteriia	204432|Acidobacteriia	P	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_489551_9	1535422.ND16A_0718	1.889e-09	65.0	COG3409@1|root,COG3409@2|Bacteria,1NB3C@1224|Proteobacteria,1SDV0@1236|Gammaproteobacteria,2Q8CH@267889|Colwelliaceae	1236|Gammaproteobacteria	M	Peptidoglycan-binding domain 1 protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_489551_2	243233.MCA1608	5.416e-102	351.0	COG2251@1|root,COG2251@2|Bacteria,1QUUG@1224|Proteobacteria,1T3FR@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Domain of unknown function(DUF2779)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2779
HKD2_k127_489551_0	887062.HGR_05459	3.681e-148	475.0	COG2230@1|root,COG2230@2|Bacteria,1MX3U@1224|Proteobacteria,2VJ00@28216|Betaproteobacteria,4AC6Q@80864|Comamonadaceae	28216|Betaproteobacteria	M	Cyclopropane-fatty-acyl-phospholipid synthase	cfa	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008168,GO:0008610,GO:0008757,GO:0009058,GO:0009059,GO:0009273,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016741,GO:0019752,GO:0030312,GO:0032259,GO:0032787,GO:0034645,GO:0042546,GO:0043170,GO:0043436,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0070589,GO:0071554,GO:0071704,GO:0071766,GO:0071767,GO:0071768,GO:0071840,GO:0071944,GO:0072330,GO:1901576	2.1.1.79	ko:K00574	-	-	-	-	ko00000,ko01000	-	-	-	CMAS
HKD2_k127_493064_10	1384056.N787_02780	2.41e-09	59.0	COG0591@1|root,COG0642@1|root,COG0745@1|root,COG0591@2|Bacteria,COG0745@2|Bacteria,COG2205@2|Bacteria,1MUY7@1224|Proteobacteria,1RP2U@1236|Gammaproteobacteria,1X43U@135614|Xanthomonadales	135614|Xanthomonadales	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_7,Response_reg
HKD2_k127_493064_6	570952.ATVH01000011_gene197	1.807e-118	392.0	COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,2TQN9@28211|Alphaproteobacteria,2JQE6@204441|Rhodospirillales	204441|Rhodospirillales	E	Pyridoxal-phosphate dependent enzyme	-	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HKD2_k127_493064_7	584708.Apau_0960	1.214e-109	368.0	COG2265@1|root,COG2265@2|Bacteria,3TAEF@508458|Synergistetes	508458|Synergistetes	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	tRNA_U5-meth_tr
HKD2_k127_493064_4	497964.CfE428DRAFT_5240	7.701e-127	438.0	COG2326@1|root,COG2326@2|Bacteria,46SAH@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Polyphosphate kinase 2 (PPK2)	-	-	-	-	-	-	-	-	-	-	-	-	PPK2
HKD2_k127_493064_5	381666.H16_B2544	4.613e-121	421.0	COG1752@1|root,COG4775@1|root,COG1752@2|Bacteria,COG4775@2|Bacteria,1MUM9@1224|Proteobacteria,2VJRI@28216|Betaproteobacteria,1KBZ2@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Surface antigen	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Bac_surface_Ag,POTRA,Patatin
HKD2_k127_493064_8	1248760.ANFZ01000006_gene2546	2.495e-102	354.0	COG0793@1|root,COG0793@2|Bacteria,1MUA3@1224|Proteobacteria,2U1FI@28211|Alphaproteobacteria,2K0WR@204457|Sphingomonadales	204457|Sphingomonadales	M	Peptidase family S41	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S41
HKD2_k127_493064_0	1056512.D515_04118	4.502e-246	784.0	COG2873@1|root,COG2873@2|Bacteria,1R3QG@1224|Proteobacteria,1RNSA@1236|Gammaproteobacteria,1XUQ3@135623|Vibrionales	135623|Vibrionales	E	Cys Met metabolism pyridoxal-phosphate-dependent enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Cys_Met_Meta_PP
HKD2_k127_493064_2	857087.Metme_2063	4.83e-206	659.0	COG3291@1|root,COG3291@2|Bacteria,1R5MQ@1224|Proteobacteria,1TI1G@1236|Gammaproteobacteria,1XGA7@135618|Methylococcales	135618|Methylococcales	C	Cytochrome c5530 family protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_493064_3	857087.Metme_2063	1.423e-204	653.0	COG3291@1|root,COG3291@2|Bacteria,1R5MQ@1224|Proteobacteria,1TI1G@1236|Gammaproteobacteria,1XGA7@135618|Methylococcales	135618|Methylococcales	C	Cytochrome c5530 family protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_493064_1	522306.CAP2UW1_1025	2.913e-232	725.0	COG2873@1|root,COG2873@2|Bacteria,1NQME@1224|Proteobacteria,2VHYA@28216|Betaproteobacteria,1KQGY@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	E	Cys/Met metabolism PLP-dependent enzyme	metY	-	2.5.1.49	ko:K01740	ko00270,ko01100,map00270,map01100	-	R01287,R04859	RC00020,RC02821,RC02848	ko00000,ko00001,ko01000	-	-	-	Cys_Met_Meta_PP
HKD2_k127_5109055_26	1122951.ATUE01000006_gene1497	1.985e-34	133.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,1RM93@1236|Gammaproteobacteria,3NK7D@468|Moraxellaceae	1236|Gammaproteobacteria	I	Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed	fadA	GO:0003674,GO:0003824,GO:0003988,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016408,GO:0016740,GO:0016746,GO:0016747,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575	2.3.1.16	ko:K00632	ko00071,ko00280,ko00281,ko00362,ko00592,ko00642,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00362,map00592,map00642,map01100,map01110,map01120,map01130,map01212	M00087,M00113	R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000	-	-	iAPECO1_1312.APECO1_2612,iECNA114_1301.ECNA114_4154,iECOK1_1307.ECOK1_4314,iECP_1309.ECP_4058,iECS88_1305.ECS88_4293,iECSF_1327.ECSF_3702,iEcE24377_1341.EcE24377A_4364,iLF82_1304.LF82_0613,iNRG857_1313.NRG857_19195,iPC815.YPO3767	Thiolase_C,Thiolase_N
HKD2_k127_5109055_1	1122951.ATUE01000006_gene1498	0.0	1055.0	COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,1RMZ8@1236|Gammaproteobacteria,3NIPR@468|Moraxellaceae	1236|Gammaproteobacteria	I	Involved in the aerobic and anaerobic degradation of long-chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate	fadB	GO:0003674,GO:0003824,GO:0003857,GO:0004165,GO:0004300,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0008692,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016854,GO:0016856,GO:0016860,GO:0016863,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575	1.1.1.35,4.2.1.17,5.1.2.3,5.3.3.8	ko:K01782,ko:K01825	ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212	M00032,M00087	R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R04756,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094	RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01078,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	iLF82_1304.LF82_0614,iNRG857_1313.NRG857_19200	3HCDH,3HCDH_N,ECH_1
HKD2_k127_5109055_8	1122604.JONR01000010_gene3999	1.658e-191	618.0	COG0741@1|root,COG0741@2|Bacteria,1MV3F@1224|Proteobacteria,1RMS8@1236|Gammaproteobacteria,1X4NS@135614|Xanthomonadales	135614|Xanthomonadales	M	Lytic murein transglycosylase	slt	-	-	ko:K08309	-	-	-	-	ko00000,ko01000,ko01011	-	GH23	-	SLT,SLT_L
HKD2_k127_5109055_24	1279009.ADICEAN_00034	6.868e-40	155.0	2C8PG@1|root,32RMK@2|Bacteria,4P5DF@976|Bacteroidetes,47VYD@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5109055_15	765911.Thivi_3292	1.566e-112	374.0	COG4589@1|root,COG4589@2|Bacteria,1MX58@1224|Proteobacteria,1RRAG@1236|Gammaproteobacteria,1WY6I@135613|Chromatiales	135613|Chromatiales	I	Cytidylyltransferase family	-	-	2.7.7.41	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_1
HKD2_k127_5109055_20	631362.Thi970DRAFT_04637	2.248e-55	200.0	COG0204@1|root,COG0204@2|Bacteria,1RA8V@1224|Proteobacteria,1RSDQ@1236|Gammaproteobacteria,1WZI7@135613|Chromatiales	135613|Chromatiales	I	Phosphate acyltransferases	-	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
HKD2_k127_5109055_22	1044.EH31_14965	5.052e-42	163.0	COG0558@1|root,COG0558@2|Bacteria,1RHFC@1224|Proteobacteria,2UACA@28211|Alphaproteobacteria,2KA7A@204457|Sphingomonadales	204457|Sphingomonadales	I	cdp-diacylglycerol--glycerol-3-phosphate	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5109055_16	1469245.JFBG01000080_gene290	7.237e-104	347.0	COG1163@1|root,COG1163@2|Bacteria,1RFPD@1224|Proteobacteria	1224|Proteobacteria	S	TGS domain	-	-	-	ko:K06944	-	-	-	-	ko00000	-	-	-	MMR_HSR1,TGS
HKD2_k127_5109055_9	1234364.AMSF01000033_gene402	5.627e-160	524.0	COG0364@1|root,COG0364@2|Bacteria,1MUN0@1224|Proteobacteria,1RQE4@1236|Gammaproteobacteria,1X59Z@135614|Xanthomonadales	135614|Xanthomonadales	G	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone	-	-	1.1.1.363,1.1.1.49	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	M00004,M00006,M00008	R00835,R02736,R10907	RC00001,RC00066	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	G6PD_C,G6PD_N
HKD2_k127_5109055_21	404589.Anae109_0599	5.093e-53	203.0	COG0363@1|root,COG0363@2|Bacteria,1R5K6@1224|Proteobacteria	1224|Proteobacteria	G	6-phosphogluconolactonase	pgl	-	2.7.1.12,3.1.1.31	ko:K00851,ko:K01057	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200	M00004,M00006,M00008	R01737,R02035	RC00002,RC00017,RC00537	ko00000,ko00001,ko00002,ko01000	-	-	-	Glucosamine_iso
HKD2_k127_5109055_18	1265310.CCBD010000007_gene2956	1.977e-74	259.0	COG1024@1|root,COG1024@2|Bacteria,2I9MR@201174|Actinobacteria,2373R@1762|Mycobacteriaceae	201174|Actinobacteria	I	Enoyl-CoA hydratase	echA8_1	-	-	-	-	-	-	-	-	-	-	-	ECH_1
HKD2_k127_5109055_0	870187.Thini_0322	0.0	1408.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MUT8@1224|Proteobacteria,1RN6R@1236|Gammaproteobacteria,460EP@72273|Thiotrichales	72273|Thiotrichales	G	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
HKD2_k127_5109055_23	1415780.JPOG01000001_gene2196	2.427e-40	166.0	COG3714@1|root,COG3714@2|Bacteria,1QE44@1224|Proteobacteria,1TAFY@1236|Gammaproteobacteria,1X8EB@135614|Xanthomonadales	135614|Xanthomonadales	S	YhhN family	-	-	-	-	-	-	-	-	-	-	-	-	YhhN
HKD2_k127_5109055_10	550540.Fbal_1135	5.554e-153	504.0	COG0665@1|root,COG0665@2|Bacteria,1MVGP@1224|Proteobacteria,1RNJ9@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	oxidoreductase	ordL	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0016491,GO:0044424,GO:0044464,GO:0055114	-	ko:K09471	ko00330,ko01100,map00330,map01100	M00136	R07415	RC00062	ko00000,ko00001,ko00002,ko01000	-	-	-	DAO
HKD2_k127_5109055_17	1198452.Jab_2c23490	4.534e-100	339.0	COG1752@1|root,COG1752@2|Bacteria,1MU6Z@1224|Proteobacteria,2VHBX@28216|Betaproteobacteria,473T3@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Esterase of the alpha-beta hydrolase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Patatin
HKD2_k127_5109055_25	522306.CAP2UW1_3689	8.77e-35	143.0	2C0PI@1|root,32VVI@2|Bacteria,1N1H7@1224|Proteobacteria,2VUDK@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5109055_5	159087.Daro_3713	6.744e-211	661.0	COG3876@1|root,COG3876@2|Bacteria,1MX3S@1224|Proteobacteria,2VMMF@28216|Betaproteobacteria,2KV9B@206389|Rhodocyclales	206389|Rhodocyclales	S	Protein of unknown function (DUF1343)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1343
HKD2_k127_5109055_7	29581.BW37_03849	2.145e-200	635.0	COG0578@1|root,COG0578@2|Bacteria,1MUMY@1224|Proteobacteria,2VN8I@28216|Betaproteobacteria,472EJ@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family	glpD	-	1.1.5.3	ko:K00111	ko00564,ko01110,map00564,map01110	-	R00848	RC00029	ko00000,ko00001,ko01000	-	-	-	DAO,DAO_C
HKD2_k127_5109055_6	1540221.JQNI01000004_gene194	3.826e-210	663.0	COG0554@1|root,COG0554@2|Bacteria,1WI6Q@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate	glpK	GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615	2.7.1.30	ko:K00864	ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626	-	R00847	RC00002,RC00017	ko00000,ko00001,ko01000,ko04147	-	-	-	FGGY_C,FGGY_N
HKD2_k127_5109055_11	595537.Varpa_5280	2.827e-145	469.0	COG3000@1|root,COG3714@1|root,COG3000@2|Bacteria,COG3714@2|Bacteria,1NR7X@1224|Proteobacteria,2VJ4E@28216|Betaproteobacteria,4ABMB@80864|Comamonadaceae	28216|Betaproteobacteria	I	PFAM fatty acid hydroxylase	-	-	-	-	-	-	-	-	-	-	-	-	FA_hydroxylase,YhhN
HKD2_k127_5109055_3	1385935.N836_20045	2.98e-274	873.0	COG0474@1|root,COG0474@2|Bacteria,1G0JX@1117|Cyanobacteria,1H7PF@1150|Oscillatoriales	1117|Cyanobacteria	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
HKD2_k127_5109055_29	317013.NY99_19795	0.0001206	52.0	COG3047@1|root,COG3047@2|Bacteria,1NUZJ@1224|Proteobacteria,1RRRC@1236|Gammaproteobacteria,1X5TV@135614|Xanthomonadales	135614|Xanthomonadales	M	Outer membrane protein W	ompW1	-	-	ko:K07275	-	-	-	-	ko00000	-	-	-	OmpW
HKD2_k127_5109055_4	1122951.ATUE01000006_gene1361	6.888e-241	754.0	COG1233@1|root,COG1233@2|Bacteria,1MV2R@1224|Proteobacteria,1RMGJ@1236|Gammaproteobacteria,3NPIS@468|Moraxellaceae	1236|Gammaproteobacteria	Q	Flavin containing amine oxidoreductase	-	-	1.3.99.23	ko:K09516	ko00830,map00830	-	R07163	RC01835	ko00000,ko00001,ko01000	-	-	-	Amino_oxidase,FAD_binding_6,NAD_binding_1,NAD_binding_8
HKD2_k127_5109055_12	1123073.KB899242_gene1574	3.392e-134	446.0	COG3954@1|root,COG3954@2|Bacteria,1MWN9@1224|Proteobacteria,1RMS7@1236|Gammaproteobacteria,1X5H5@135614|Xanthomonadales	135614|Xanthomonadales	C	Phosphoribulokinase / Uridine kinase family	-	-	-	-	-	-	-	-	-	-	-	-	PRK
HKD2_k127_5109055_13	75379.Tint_0136	1.052e-132	451.0	COG0158@1|root,COG0158@2|Bacteria,1MW0E@1224|Proteobacteria,2VIJT@28216|Betaproteobacteria,1KKER@119065|unclassified Burkholderiales	28216|Betaproteobacteria	G	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1	fbp2	-	3.1.3.11,3.1.3.37	ko:K01086,ko:K03841	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko04152,ko04910,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map04152,map04910	M00003,M00165,M00167,M00344	R00762,R01845,R04780	RC00017	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	FBPase
HKD2_k127_5109055_14	159450.NH14_07930	1.646e-124	411.0	COG0464@1|root,COG0464@2|Bacteria,1MUCN@1224|Proteobacteria,2VIA8@28216|Betaproteobacteria,1K15U@119060|Burkholderiaceae	28216|Betaproteobacteria	O	CbbX protein	cbbX	-	-	-	-	-	-	-	-	-	-	-	AAA
HKD2_k127_5109055_19	1187851.A33M_4374	4.626e-60	209.0	COG4451@1|root,COG4451@2|Bacteria,1R9ZE@1224|Proteobacteria,2U7JJ@28211|Alphaproteobacteria,3FDI4@34008|Rhodovulum	28211|Alphaproteobacteria	C	Ribulose bisphosphate carboxylase, small chain	cbbS	-	4.1.1.39	ko:K01602	ko00630,ko00710,ko01100,ko01120,ko01200,map00630,map00710,map01100,map01120,map01200	M00165,M00166,M00532	R00024,R03140	RC00172,RC00859	ko00000,ko00001,ko00002,ko01000	-	-	-	RuBisCO_small
HKD2_k127_5109055_2	305700.B447_09153	1.038e-276	855.0	COG1850@1|root,COG1850@2|Bacteria,1MWEB@1224|Proteobacteria,2VJF4@28216|Betaproteobacteria,2KV1C@206389|Rhodocyclales	206389|Rhodocyclales	H	RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site	rbcL	-	4.1.1.39	ko:K01601	ko00630,ko00710,ko01100,ko01120,ko01200,map00630,map00710,map01100,map01120,map01200	M00165,M00166,M00532	R00024,R03140	RC00172,RC00859	ko00000,ko00001,ko00002,ko01000	-	-	-	RuBisCO_large,RuBisCO_large_N
HKD2_k127_5109055_27	743299.Acife_1239	4.15e-11	64.0	COG0583@1|root,COG0583@2|Bacteria,1MWVU@1224|Proteobacteria,1RPT8@1236|Gammaproteobacteria,2NBS6@225057|Acidithiobacillales	225057|Acidithiobacillales	K	LysR substrate binding domain	-	-	-	ko:K21703	-	-	-	-	ko00000,ko03000	-	-	-	HTH_1,LysR_substrate
HKD2_k127_5110690_1	1123269.NX02_24375	4.792e-40	156.0	COG0308@1|root,COG0308@2|Bacteria,1MUCI@1224|Proteobacteria,2TRUM@28211|Alphaproteobacteria,2K13Z@204457|Sphingomonadales	204457|Sphingomonadales	E	aminopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	ERAP1_C,Peptidase_M1
HKD2_k127_5110690_0	1453501.JELR01000001_gene2627	8.904e-127	415.0	COG0304@1|root,COG0304@2|Bacteria,1MV67@1224|Proteobacteria,1RMXJ@1236|Gammaproteobacteria,4660E@72275|Alteromonadaceae	1236|Gammaproteobacteria	IQ	Beta-ketoacyl synthase, C-terminal domain	-	-	2.3.1.180	ko:K18473	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
HKD2_k127_5110720_0	519989.ECTPHS_03672	6.627e-184	591.0	COG0072@1|root,COG0072@2|Bacteria,1MWKS@1224|Proteobacteria,1RMIH@1236|Gammaproteobacteria,1WW51@135613|Chromatiales	135613|Chromatiales	J	Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily	pheT	-	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,tRNA_bind
HKD2_k127_5110720_1	765912.Thimo_2824	1.52e-141	460.0	COG0016@1|root,COG0016@2|Bacteria,1MVD7@1224|Proteobacteria,1RN22@1236|Gammaproteobacteria,1WXAD@135613|Chromatiales	135613|Chromatiales	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily	pheS	-	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Phe_tRNA-synt_N,tRNA-synt_2d
HKD2_k127_5110720_4	1269813.ATUL01000025_gene2753	7.649e-49	176.0	COG0292@1|root,COG0292@2|Bacteria,1RGU2@1224|Proteobacteria,1S3P3@1236|Gammaproteobacteria,1WYQC@135613|Chromatiales	135613|Chromatiales	J	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit	rplT	-	-	ko:K02887	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L20
HKD2_k127_5110720_5	1201293.AKXQ01000028_gene1328	1.672e-17	83.0	COG0291@1|root,COG0291@2|Bacteria,1N6V4@1224|Proteobacteria,1SCHI@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	Belongs to the bacterial ribosomal protein bL35 family	rpmI	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02916	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L35p
HKD2_k127_5110720_3	765911.Thivi_1564	8.07e-67	231.0	COG0290@1|root,COG0290@2|Bacteria,1RDD2@1224|Proteobacteria,1S4E6@1236|Gammaproteobacteria,1WWSS@135613|Chromatiales	135613|Chromatiales	J	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins	infC	-	-	ko:K02520	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	IF3_C,IF3_N
HKD2_k127_5110720_2	1238182.C882_1247	5.469e-118	384.0	COG0441@1|root,COG0441@2|Bacteria,1MUP2@1224|Proteobacteria,2TQWI@28211|Alphaproteobacteria,2JQ7K@204441|Rhodospirillales	204441|Rhodospirillales	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	-	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD
HKD2_k127_51486_27	702113.PP1Y_AT11717	2.432e-137	451.0	COG0477@1|root,COG2814@2|Bacteria,1MVQQ@1224|Proteobacteria,2TRBF@28211|Alphaproteobacteria,2K261@204457|Sphingomonadales	204457|Sphingomonadales	EGP	Major Facilitator	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD2_k127_51486_29	627192.SLG_25030	5.713e-135	434.0	COG1024@1|root,COG1024@2|Bacteria,1MVB1@1224|Proteobacteria,2TVK3@28211|Alphaproteobacteria,2K2WS@204457|Sphingomonadales	204457|Sphingomonadales	I	Catalyzes the conversion of feruloyl-CoA to vanillin and acetyl-CoA	ferB	-	4.1.2.41,4.2.1.101	ko:K18383	ko00360,ko01100,ko01110,map00360,map01100,map01110	-	R05772,R05773	RC00307,RC01468,RC01828	ko00000,ko00001,ko01000	-	-	-	ECH_1
HKD2_k127_51486_7	1122612.AUBA01000015_gene882	2.273e-248	779.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2TQR1@28211|Alphaproteobacteria,2JZVD@204457|Sphingomonadales	204457|Sphingomonadales	C	belongs to the aldehyde dehydrogenase family	-	-	1.2.1.39	ko:K00146	ko00360,ko00643,ko01100,ko01120,map00360,map00643,map01100,map01120	-	R02536	RC00080	ko00000,ko00001,ko01000	-	-	-	Aldedh
HKD2_k127_51486_30	62928.azo2535	1.173e-133	449.0	COG0667@1|root,COG0667@2|Bacteria,1MVEH@1224|Proteobacteria,2VH1Q@28216|Betaproteobacteria,2KVKF@206389|Rhodocyclales	206389|Rhodocyclales	C	oxidoreductases (related to aryl-alcohol dehydrogenases)	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
HKD2_k127_51486_19	258594.RPA4703	1.242e-158	514.0	COG0673@1|root,COG0673@2|Bacteria,1MXUP@1224|Proteobacteria,2TV6R@28211|Alphaproteobacteria,3JWGS@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Oxidoreductase family, NAD-binding Rossmann fold	ligC	-	1.1.1.312	ko:K10219	ko00350,ko00362,ko00627,ko01120,ko01220,map00350,map00362,map00627,map01120,map01220	M00533	R04278,R04279,R04418,R04419	RC00251,RC00254	ko00000,ko00001,ko00002,ko01000	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
HKD2_k127_51486_26	1158292.JPOE01000005_gene198	1.011e-143	468.0	COG3384@1|root,COG3384@2|Bacteria,1MW77@1224|Proteobacteria,2VI4U@28216|Betaproteobacteria,1KKIV@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Catalytic LigB subunit of aromatic ring-opening dioxygenase	ligB	-	1.13.11.57,1.13.11.8	ko:K04099,ko:K04101	ko00362,ko00624,ko00627,ko01120,map00362,map00624,map00627,map01120	-	R01632,R03550,R04280,R09565	RC00233,RC00387,RC00535,RC02567,RC02694	br01602,ko00000,ko00001,ko01000	-	-	-	LigA,LigB
HKD2_k127_51486_47	1437824.BN940_08551	1.273e-57	209.0	COG3384@1|root,COG3384@2|Bacteria,1RA8A@1224|Proteobacteria,2VQ2B@28216|Betaproteobacteria,3T7IJ@506|Alcaligenaceae	28216|Betaproteobacteria	S	Aromatic-ring-opening dioxygenase LigAB, LigA subunit	-	-	1.13.11.8	ko:K04100	ko00362,ko00624,ko00627,ko01120,map00362,map00624,map00627,map01120	-	R01632,R03550,R04280,R09565	RC00233,RC00387,RC00535,RC02567,RC02694	br01602,ko00000,ko00001,ko01000	-	-	-	LigA
HKD2_k127_51486_25	1118235.CAJH01000009_gene526	4.414e-144	474.0	COG3618@1|root,COG3618@2|Bacteria,1N2QM@1224|Proteobacteria,1RQ8V@1236|Gammaproteobacteria,1X6AE@135614|Xanthomonadales	135614|Xanthomonadales	S	Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
HKD2_k127_51486_14	1217720.ALOX01000032_gene168	1.257e-191	601.0	COG2159@1|root,COG2159@2|Bacteria,1MVHB@1224|Proteobacteria,2TVM0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	4-oxalomesaconate hydratase	ligJ	-	4.1.1.45,4.2.1.83	ko:K03392,ko:K10220	ko00362,ko00380,ko01100,ko01120,map00362,map00380,map01100,map01120	M00038	R04323,R04478	RC00498,RC00779	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_2
HKD2_k127_51486_42	1043493.BBLU01000004_gene2674	3.972e-74	264.0	COG2084@1|root,COG2084@2|Bacteria,2ICA7@201174|Actinobacteria	201174|Actinobacteria	I	6-phosphogluconate dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	DUF1932,NAD_binding_2
HKD2_k127_51486_24	1168065.DOK_12291	2.07e-144	470.0	COG2828@1|root,COG2828@2|Bacteria,1MXVV@1224|Proteobacteria,1RNE6@1236|Gammaproteobacteria,1J5BN@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	protein conserved in bacteria	galD	GO:0003674,GO:0003824,GO:0006082,GO:0006725,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016054,GO:0016853,GO:0016860,GO:0016863,GO:0017144,GO:0018918,GO:0018958,GO:0019336,GO:0019396,GO:0019439,GO:0019752,GO:0032787,GO:0042537,GO:0042737,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0071704,GO:0072329,GO:1901360,GO:1901361,GO:1901575,GO:1901615,GO:1901616	5.3.2.8	ko:K16514	ko00362,ko01120,map00362,map01120	-	R07839	RC02426	ko00000,ko00001,ko01000	-	-	-	PrpF
HKD2_k127_51486_34	266834.SMc00502	1.249e-95	322.0	COG0684@1|root,COG0684@2|Bacteria,1MW9P@1224|Proteobacteria,2TTGT@28211|Alphaproteobacteria,4B9GM@82115|Rhizobiaceae	28211|Alphaproteobacteria	H	Aldolase/RraA	ligK	-	4.1.3.17	ko:K02553,ko:K10218	ko00362,ko00660,ko01120,map00362,map00660,map01120	-	R00008,R00350	RC00067,RC00502,RC01205	ko00000,ko00001,ko01000,ko03019	-	-	-	RraA-like
HKD2_k127_51486_11	381666.H16_A1113	1.033e-206	656.0	COG0028@1|root,COG0028@2|Bacteria,1MX6Q@1224|Proteobacteria,2VIGQ@28216|Betaproteobacteria,1K395@119060|Burkholderiaceae	28216|Betaproteobacteria	EH	Belongs to the TPP enzyme family	mdlC	-	4.1.1.7	ko:K01576	ko00627,ko01120,map00627,map01120	-	R01764,R02672	RC00595	ko00000,ko00001,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
HKD2_k127_51486_13	497321.C664_15668	8.075e-194	616.0	COG3384@1|root,COG3384@2|Bacteria,1MW77@1224|Proteobacteria,2VI4U@28216|Betaproteobacteria	28216|Betaproteobacteria	S	PFAM Extradiol ring-cleavage dioxygenase class III protein subunit B	ligB	-	1.13.11.57	ko:K04099	ko00627,ko01120,map00627,map01120	-	R03550,R04280,R09565	RC00233,RC00535,RC02567,RC02694	ko00000,ko00001,ko01000	-	-	-	LigA,LigB
HKD2_k127_51486_54	526227.Mesil_3475	9.594e-29	118.0	COG4274@1|root,COG4274@2|Bacteria	2|Bacteria	S	GYD domain	-	-	-	-	-	-	-	-	-	-	-	-	GYD
HKD2_k127_51486_62	381666.H16_A1676	2.848e-05	49.0	COG0431@1|root,COG0431@2|Bacteria,1RAFI@1224|Proteobacteria,2VKQS@28216|Betaproteobacteria,1K02Y@119060|Burkholderiaceae	28216|Betaproteobacteria	S	NADPH-dependent FMN reductase	-	-	-	ko:K19784	-	-	-	-	ko00000	-	-	-	FMN_red
HKD2_k127_51486_32	497964.CfE428DRAFT_1821	2.276e-111	368.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	NHL
HKD2_k127_51486_20	1123072.AUDH01000002_gene2548	4.283e-158	511.0	COG0457@1|root,COG0457@2|Bacteria,1N01S@1224|Proteobacteria,2TSR4@28211|Alphaproteobacteria,2JQKI@204441|Rhodospirillales	204441|Rhodospirillales	S	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_51486_55	1356852.N008_20065	7.823e-25	108.0	COG4319@1|root,COG4319@2|Bacteria,4PKK4@976|Bacteroidetes,47W5Y@768503|Cytophagia	976|Bacteroidetes	S	Domain of unknown function (DUF4440)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440
HKD2_k127_51486_58	399739.Pmen_4353	6.11e-23	108.0	COG0664@1|root,COG0664@2|Bacteria,1RE4X@1224|Proteobacteria,1S4QX@1236|Gammaproteobacteria,1YEPD@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	K	helix_turn_helix, cAMP Regulatory protein	-	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
HKD2_k127_51486_18	1122604.JONR01000071_gene4514	1.987e-162	544.0	COG1196@1|root,COG1196@2|Bacteria,1R4SX@1224|Proteobacteria,1RVI9@1236|Gammaproteobacteria,1X8VV@135614|Xanthomonadales	135614|Xanthomonadales	D	Domain of Unknown Function (DUF349)	-	-	-	-	-	-	-	-	-	-	-	-	DUF349
HKD2_k127_51486_48	1038860.AXAP01000003_gene8216	1.686e-56	205.0	COG1309@1|root,COG1309@2|Bacteria,1N8IR@1224|Proteobacteria,2U336@28211|Alphaproteobacteria,3JVKF@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_13,TetR_N
HKD2_k127_51486_1	243160.BMA1612	0.0	1098.0	COG0243@1|root,COG0243@2|Bacteria,1NS3T@1224|Proteobacteria,2VIB1@28216|Betaproteobacteria,1KDQ8@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Molybdopterin oxidoreductase Fe4S4 domain	-	-	-	-	-	-	-	-	-	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
HKD2_k127_51486_57	667632.KB890185_gene478	3.683e-23	103.0	COG3360@1|root,COG3360@2|Bacteria,1PW6C@1224|Proteobacteria,2VXDE@28216|Betaproteobacteria,1KB0W@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Dodecin	-	-	-	ko:K09165	-	-	-	-	ko00000	-	-	-	Dodecin
HKD2_k127_51486_35	440512.C211_21257	2.228e-93	310.0	2C1VC@1|root,2Z83Q@2|Bacteria,1MV9V@1224|Proteobacteria,1S31Q@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_51486_53	1458275.AZ34_14860	1.887e-41	156.0	2DBI3@1|root,32TXG@2|Bacteria,1RF32@1224|Proteobacteria,2W4D7@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	YCII
HKD2_k127_51486_4	264198.Reut_B4712	9.622e-306	947.0	COG3119@1|root,COG3119@2|Bacteria,1MV0B@1224|Proteobacteria,2VNB8@28216|Betaproteobacteria,1KGH9@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
HKD2_k127_51486_12	983917.RGE_08450	1.527e-206	647.0	COG1473@1|root,COG1473@2|Bacteria,1MUIV@1224|Proteobacteria,2VIS0@28216|Betaproteobacteria,1KJJ9@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Peptidase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
HKD2_k127_51486_15	639030.JHVA01000001_gene592	6.362e-184	591.0	COG0591@1|root,COG0591@2|Bacteria,3Y3RT@57723|Acidobacteria,2JHK6@204432|Acidobacteriia	2|Bacteria	E	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	yhjB	-	-	ko:K03307	-	-	-	-	ko00000	2.A.21	-	-	SSF
HKD2_k127_51486_37	1276756.AUEX01000028_gene2128	7.662e-83	287.0	COG0697@1|root,COG0697@2|Bacteria,1MXJ6@1224|Proteobacteria,2VIA7@28216|Betaproteobacteria,4AHW3@80864|Comamonadaceae	28216|Betaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HKD2_k127_51486_49	748247.AZKH_1953	7.87e-55	201.0	2C6CV@1|root,33W8F@2|Bacteria,1RM05@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_51486_31	748247.AZKH_1952	1.875e-114	374.0	COG0596@1|root,COG0596@2|Bacteria,1N5ZI@1224|Proteobacteria,2VJ9I@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
HKD2_k127_51486_9	1430440.MGMSRv2_2570	6.34e-225	724.0	COG0380@1|root,COG0380@2|Bacteria,1MUIY@1224|Proteobacteria,2TQMP@28211|Alphaproteobacteria,2JPVA@204441|Rhodospirillales	204441|Rhodospirillales	G	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor	otsA	-	2.4.1.15,2.4.1.347	ko:K00697	ko00500,ko01100,map00500,map01100	-	R02737	RC00005,RC00049,RC02748	ko00000,ko00001,ko01000,ko01003	-	GT20	-	Glyco_transf_20
HKD2_k127_51486_10	314278.NB231_12004	2.291e-219	698.0	COG3387@1|root,COG3387@2|Bacteria,1MV08@1224|Proteobacteria,1RS4U@1236|Gammaproteobacteria,1X0E1@135613|Chromatiales	135613|Chromatiales	G	Glycosyl hydrolases family 15	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_15
HKD2_k127_51486_50	359.CN09_14315	3.609e-52	194.0	COG1877@1|root,COG1877@2|Bacteria,1RGY2@1224|Proteobacteria,2U9NF@28211|Alphaproteobacteria,4BCQC@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	Removes the phosphate from trehalose 6-phosphate to produce free trehalose	otsB	-	3.1.3.12	ko:K01087	ko00500,ko01100,map00500,map01100	-	R02778	RC00017	ko00000,ko00001,ko01000	-	-	-	Trehalose_PPase
HKD2_k127_51486_43	1121033.AUCF01000001_gene2120	9.995e-70	250.0	COG0583@1|root,COG0583@2|Bacteria,1MWY0@1224|Proteobacteria,2TSD9@28211|Alphaproteobacteria,2JQUN@204441|Rhodospirillales	204441|Rhodospirillales	K	LysR substrate binding domain	-	-	-	ko:K03566	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_1,LysR_substrate
HKD2_k127_51486_28	1163617.SCD_n01205	4.605e-136	447.0	COG0038@1|root,COG0038@2|Bacteria,1MV4K@1224|Proteobacteria,2VHFE@28216|Betaproteobacteria	28216|Betaproteobacteria	P	Chloride channel	clcA	-	-	-	-	-	-	-	-	-	-	-	Voltage_CLC
HKD2_k127_51486_5	264198.Reut_A1185	4.959e-305	956.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,2VNZQ@28216|Betaproteobacteria,1KGKU@119060|Burkholderiaceae	28216|Betaproteobacteria	P	E1-E2 ATPase	-	-	3.6.3.6	ko:K01535	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.3.3	-	-	Cation_ATPase_N,E1-E2_ATPase,Hydrolase
HKD2_k127_51486_22	1385517.N800_04690	7.714e-148	478.0	COG0845@1|root,COG0845@2|Bacteria,1MU78@1224|Proteobacteria,1RPI1@1236|Gammaproteobacteria,1X3FF@135614|Xanthomonadales	135614|Xanthomonadales	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	mexA	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	Biotin_lipoyl_2,HlyD,HlyD_D23
HKD2_k127_51486_0	204773.HEAR2382	0.0	1577.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHFI@28216|Betaproteobacteria,472ZI@75682|Oxalobacteraceae	28216|Betaproteobacteria	U	Efflux pump	acrB	-	-	ko:K03296,ko:K18138,ko:K18322	ko01501,ko01503,ko02020,map01501,map01503,map02020	M00645,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2,2.A.6.2.41	-	-	ACR_tran
HKD2_k127_51486_17	1118235.CAJH01000063_gene3501	1.162e-163	529.0	COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,1RMDA@1236|Gammaproteobacteria,1X3EU@135614|Xanthomonadales	135614|Xanthomonadales	M	Outer membrane efflux protein	oprM	-	-	ko:K18139	ko01501,ko02024,map01501,map02024	M00642,M00643,M00647,M00718,M00768,M00822	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	1.B.17,2.A.6.2	-	-	OEP
HKD2_k127_51486_52	84531.JMTZ01000014_gene2727	1.111e-45	183.0	COG1309@1|root,COG1309@2|Bacteria,1RARJ@1224|Proteobacteria,1RYD5@1236|Gammaproteobacteria,1X7IN@135614|Xanthomonadales	135614|Xanthomonadales	K	BetI-type transcriptional repressor, C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_6,TetR_N
HKD2_k127_51486_16	335283.Neut_1292	5.148e-171	548.0	COG0448@1|root,COG0448@2|Bacteria,1MVTC@1224|Proteobacteria,2VIP2@28216|Betaproteobacteria,372V3@32003|Nitrosomonadales	28216|Betaproteobacteria	H	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans	glgC	-	2.7.7.27	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	M00565	R00948	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
HKD2_k127_51486_40	1088721.NSU_0979	2.727e-76	263.0	COG3279@1|root,COG3279@2|Bacteria,1MUE8@1224|Proteobacteria,2TSPC@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Response regulator of the LytR AlgR family	-	-	-	ko:K02477	-	-	-	-	ko00000,ko02022	-	-	-	LytTR,Response_reg
HKD2_k127_51486_56	1088721.NSU_0980	2.274e-24	107.0	COG1917@1|root,COG1917@2|Bacteria	2|Bacteria	L	Cupin 2, conserved barrel domain protein	-	-	-	ko:K21700	-	-	-	-	ko00000	-	-	-	Cupin_2
HKD2_k127_51486_60	666685.R2APBS1_1583	3.248e-09	69.0	COG2972@1|root,COG2972@2|Bacteria,1MXVQ@1224|Proteobacteria,1S5XF@1236|Gammaproteobacteria,1X4HJ@135614|Xanthomonadales	135614|Xanthomonadales	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	His_kinase
HKD2_k127_51486_46	1088721.NSU_0982	7.829e-58	215.0	COG2972@1|root,COG2972@2|Bacteria,1MXVQ@1224|Proteobacteria,2U103@28211|Alphaproteobacteria	1224|Proteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	His_kinase
HKD2_k127_51486_36	1121015.N789_02840	4.315e-87	293.0	COG0605@1|root,COG0605@2|Bacteria,1MVW2@1224|Proteobacteria,1RP7X@1236|Gammaproteobacteria,1X3PD@135614|Xanthomonadales	135614|Xanthomonadales	P	Destroys radicals which are normally produced within the cells and which are toxic to biological systems	sodB	-	1.15.1.1	ko:K04564	ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016	-	-	-	ko00000,ko00001,ko01000	-	-	-	Sod_Fe_C,Sod_Fe_N
HKD2_k127_51486_51	1121927.GOHSU_46_00260	6.801e-52	189.0	COG2128@1|root,COG2128@2|Bacteria,2H4IP@201174|Actinobacteria	201174|Actinobacteria	S	carboxymuconolactone decarboxylase	-	-	-	-	-	-	-	-	-	-	-	-	CMD
HKD2_k127_51486_44	1192034.CAP_4227	2.012e-66	235.0	COG0300@1|root,COG0300@2|Bacteria,1PG5S@1224|Proteobacteria,43473@68525|delta/epsilon subdivisions,2X263@28221|Deltaproteobacteria,2YXTC@29|Myxococcales	28221|Deltaproteobacteria	S	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HKD2_k127_51486_41	1207075.PputUW4_02593	7.748e-75	265.0	COG0300@1|root,COG0300@2|Bacteria,1QXK1@1224|Proteobacteria,1T3DF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	IQR COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,adh_short
HKD2_k127_51486_8	557599.MKAN_25710	2.158e-235	741.0	COG0028@1|root,COG0028@2|Bacteria,2GM6Y@201174|Actinobacteria,234PM@1762|Mycobacteriaceae	201174|Actinobacteria	EH	Belongs to the TPP enzyme family	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
HKD2_k127_51486_39	1217718.ALOU01000010_gene896	2.422e-80	279.0	COG2207@1|root,COG2207@2|Bacteria,1RH01@1224|Proteobacteria,2VQ3J@28216|Betaproteobacteria,1K3U6@119060|Burkholderiaceae	28216|Betaproteobacteria	K	PFAM helix-turn-helix- domain containing protein AraC type	-	-	-	-	-	-	-	-	-	-	-	-	Arabinose_bd,HTH_18
HKD2_k127_51486_6	234267.Acid_7278	5.053e-262	823.0	COG0339@1|root,COG0339@2|Bacteria,3Y2RS@57723|Acidobacteria	57723|Acidobacteria	E	M3B, thimet oligopeptidase F	-	-	3.4.24.15	ko:K01392	ko04614,ko05143,map04614,map05143	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M3
HKD2_k127_51486_61	1120963.KB894492_gene1455	5.123e-09	65.0	2C79Y@1|root,33267@2|Bacteria,1N7XV@1224|Proteobacteria,1SEFE@1236|Gammaproteobacteria,2Q2JY@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_51486_38	321846.PS417_27545	5.153e-82	279.0	COG0625@1|root,COG0625@2|Bacteria,1R9KA@1224|Proteobacteria,1S1D7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	Glutathione S-Transferase	-	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C,GST_C_3,GST_N_3
HKD2_k127_51486_3	452637.Oter_4609	5.446e-311	972.0	COG1297@1|root,COG1297@2|Bacteria	2|Bacteria	S	iron-nicotianamine transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	OPT
HKD2_k127_51486_33	1217718.ALOU01000007_gene1258	1.219e-95	323.0	COG0760@1|root,COG0760@2|Bacteria,1R4ZR@1224|Proteobacteria,2W0N2@28216|Betaproteobacteria	28216|Betaproteobacteria	O	PPIC-type PPIASE domain	-	-	-	-	-	-	-	-	-	-	-	-	Rotamase_2
HKD2_k127_51486_23	1217718.ALOU01000007_gene1259	3.571e-147	473.0	COG2370@1|root,COG2370@2|Bacteria,1MV6Z@1224|Proteobacteria,2VM5U@28216|Betaproteobacteria,1KF02@119060|Burkholderiaceae	28216|Betaproteobacteria	O	HupE / UreJ protein	-	-	-	-	-	-	-	-	-	-	-	-	HupE_UreJ_2
HKD2_k127_51486_2	1217718.ALOU01000007_gene1257	0.0	1078.0	28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria	1224|Proteobacteria	S	Protein of unknown function (DUF3604)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3604
HKD2_k127_51486_21	666681.M301_0834	1.829e-149	487.0	COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,2VISZ@28216|Betaproteobacteria,2KMNT@206350|Nitrosomonadales	206350|Nitrosomonadales	M	PFAM Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
HKD2_k127_51486_45	666681.M301_0833	7.208e-60	213.0	COG0845@1|root,COG0845@2|Bacteria,1NQZ0@1224|Proteobacteria,2VNHM@28216|Betaproteobacteria,2KMD3@206350|Nitrosomonadales	206350|Nitrosomonadales	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_D23
HKD2_k127_5182662_15	472759.Nhal_2680	1.154e-20	95.0	COG2919@1|root,COG2919@2|Bacteria,1N7AA@1224|Proteobacteria,1SD8H@1236|Gammaproteobacteria,1WZ9J@135613|Chromatiales	135613|Chromatiales	D	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic	ftsB	-	-	ko:K05589	-	-	-	-	ko00000,ko03036	-	-	-	DivIC
HKD2_k127_5182662_8	1123253.AUBD01000008_gene341	1.061e-66	240.0	COG1211@1|root,COG1211@2|Bacteria,1MY3B@1224|Proteobacteria,1S21S@1236|Gammaproteobacteria,1X3QB@135614|Xanthomonadales	135614|Xanthomonadales	I	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP)	ispD	GO:0003674,GO:0003824,GO:0016740,GO:0016772,GO:0016779,GO:0050518,GO:0070567	2.7.7.60	ko:K00991	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	IspD
HKD2_k127_5182662_9	1300345.LF41_2582	1.082e-62	220.0	COG0245@1|root,COG0245@2|Bacteria,1MVHA@1224|Proteobacteria,1S3RQ@1236|Gammaproteobacteria,1X5Z0@135614|Xanthomonadales	135614|Xanthomonadales	I	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP)	ispF	-	4.6.1.12	ko:K01770	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05637	RC00002,RC01440	ko00000,ko00001,ko00002,ko01000	-	-	-	YgbB
HKD2_k127_5182662_6	765912.Thimo_1327	3.27e-85	299.0	COG0585@1|root,COG0585@2|Bacteria,1MXHD@1224|Proteobacteria,1RPRF@1236|Gammaproteobacteria,1WWFE@135613|Chromatiales	135613|Chromatiales	J	Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs	truD	-	5.4.99.27	ko:K06176	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruD
HKD2_k127_5182662_5	1049564.TevJSym_au00580	1.025e-96	331.0	COG0496@1|root,COG0496@2|Bacteria,1MVHE@1224|Proteobacteria,1RN36@1236|Gammaproteobacteria,1J5TA@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates	surE	GO:0003674,GO:0003824,GO:0004309,GO:0005488,GO:0005515,GO:0006139,GO:0006213,GO:0006220,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008252,GO:0008253,GO:0008254,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009125,GO:0009129,GO:0009131,GO:0009158,GO:0009161,GO:0009164,GO:0009166,GO:0009173,GO:0009175,GO:0009218,GO:0009222,GO:0009259,GO:0009261,GO:0009987,GO:0016311,GO:0016462,GO:0016787,GO:0016788,GO:0016791,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0030145,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042454,GO:0042578,GO:0042802,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0046049,GO:0046050,GO:0046131,GO:0046133,GO:0046135,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0046914,GO:0055086,GO:0071704,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901657,GO:1901658	3.1.3.5	ko:K03787	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	iSFxv_1172.SFxv_3035	SurE
HKD2_k127_5182662_7	396588.Tgr7_1433	1.885e-78	271.0	COG2518@1|root,COG2518@2|Bacteria,1MXQC@1224|Proteobacteria,1RMHZ@1236|Gammaproteobacteria,1WX9P@135613|Chromatiales	135613|Chromatiales	O	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	pcm	-	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
HKD2_k127_5182662_13	713586.KB900536_gene340	7.956e-28	125.0	COG3737@1|root,COG3737@2|Bacteria,1N083@1224|Proteobacteria,1SD91@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function (DUF498/DUF598)	-	-	-	-	-	-	-	-	-	-	-	-	DUF498
HKD2_k127_5182662_12	76114.ebA5817	5.291e-29	128.0	COG4255@1|root,COG4255@2|Bacteria,1R59K@1224|Proteobacteria,2VKW9@28216|Betaproteobacteria,2KVHV@206389|Rhodocyclales	206389|Rhodocyclales	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	PhosphMutase
HKD2_k127_5182662_2	1049564.TevJSym_ac01450	1.213e-176	574.0	COG0608@1|root,COG0608@2|Bacteria,1MU1M@1224|Proteobacteria,1RMF4@1236|Gammaproteobacteria,1J5AY@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	L	COG0608 Single-stranded DNA-specific exonuclease	recJ	GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008297,GO:0008409,GO:0009314,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0033554,GO:0034641,GO:0035312,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0045145,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360	-	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
HKD2_k127_5182662_3	765914.ThisiDRAFT_1225	3.065e-160	512.0	COG1186@1|root,COG1186@2|Bacteria,1MUAW@1224|Proteobacteria,1RP9Z@1236|Gammaproteobacteria,1WWPU@135613|Chromatiales	135613|Chromatiales	J	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA	prfB	-	-	ko:K02836	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
HKD2_k127_5182662_1	765910.MARPU_08105	1.377e-210	666.0	COG1190@1|root,COG1190@2|Bacteria,1MX1V@1224|Proteobacteria,1RMJN@1236|Gammaproteobacteria,1WVXY@135613|Chromatiales	135613|Chromatiales	J	Belongs to the class-II aminoacyl-tRNA synthetase family	lysS	-	6.1.1.6	ko:K04567	ko00970,map00970	M00359,M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
HKD2_k127_5182662_10	1215092.PA6_005_00740	1.041e-38	156.0	COG0354@1|root,COG0354@2|Bacteria,1N852@1224|Proteobacteria,1RPWB@1236|Gammaproteobacteria,1YDW1@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	S	Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication	ygfZ	GO:0003674,GO:0005488,GO:0005542,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016226,GO:0019842,GO:0022607,GO:0031163,GO:0031406,GO:0033218,GO:0036094,GO:0043167,GO:0043168,GO:0043177,GO:0044085,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0051186,GO:0071840,GO:0072341,GO:0097159,GO:1901363	-	ko:K06980	-	-	-	-	ko00000,ko03016	-	-	-	GCV_T,GCV_T_C
HKD2_k127_5182662_17	340.xcc-b100_2045	8.419e-11	73.0	COG5508@1|root,COG5508@2|Bacteria,1QBN7@1224|Proteobacteria,1SGI9@1236|Gammaproteobacteria,1X8XH@135614|Xanthomonadales	135614|Xanthomonadales	S	Protein of unknown function (DUF1674)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1674
HKD2_k127_5182662_11	570952.ATVH01000013_gene2905	1.675e-30	124.0	COG2009@1|root,COG2009@2|Bacteria,1N02N@1224|Proteobacteria,2UC47@28211|Alphaproteobacteria,2JTDG@204441|Rhodospirillales	204441|Rhodospirillales	C	COG2009 Succinate dehydrogenase fumarate reductase, cytochrome b subunit	sdhC	-	-	ko:K00241	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	Sdh_cyt
HKD2_k127_5182662_14	1415780.JPOG01000001_gene1863	1.397e-22	115.0	COG2142@1|root,COG2142@2|Bacteria,1MZND@1224|Proteobacteria,1SAC6@1236|Gammaproteobacteria,1X7KQ@135614|Xanthomonadales	135614|Xanthomonadales	C	succinate dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Sdh_cyt
HKD2_k127_5182662_0	187272.Mlg_1334	1.526e-308	961.0	COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,1RMU2@1236|Gammaproteobacteria,1WW72@135613|Chromatiales	135613|Chromatiales	C	Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily	sdhA	-	1.3.5.1,1.3.5.4	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
HKD2_k127_5182662_4	1123073.KB899244_gene430	6.895e-136	437.0	COG0479@1|root,COG0479@2|Bacteria,1MVHS@1224|Proteobacteria,1RNWR@1236|Gammaproteobacteria,1X3D9@135614|Xanthomonadales	135614|Xanthomonadales	C	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family	sdhB	-	1.3.5.1,1.3.5.4	ko:K00240	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_3,Fer4_17
HKD2_k127_5182662_16	1123253.AUBD01000008_gene496	2.056e-14	76.0	COG2938@1|root,COG2938@2|Bacteria,1N7P4@1224|Proteobacteria,1SCKB@1236|Gammaproteobacteria,1X883@135614|Xanthomonadales	135614|Xanthomonadales	S	Flavinator of succinate dehydrogenase	-	-	-	ko:K09159	-	-	-	-	ko00000,ko02048	-	-	-	Sdh5
HKD2_k127_5218071_1	104623.Ser39006_00265	9.599e-19	99.0	COG0477@1|root,COG2814@2|Bacteria,1MWKH@1224|Proteobacteria,1RS23@1236|Gammaproteobacteria,401NT@613|Serratia	1236|Gammaproteobacteria	EGP	Sugar (and other) transporter	jen	-	-	ko:K08178	-	-	-	-	ko00000,ko02000	2.A.1.12	-	-	MFS_1,Sugar_tr
HKD2_k127_5218071_0	543728.Vapar_2775	1.462e-107	356.0	COG2513@1|root,COG2513@2|Bacteria,1N4VT@1224|Proteobacteria,2VZBQ@28216|Betaproteobacteria,4AH87@80864|Comamonadaceae	28216|Betaproteobacteria	G	Phosphoenolpyruvate phosphomutase	-	-	4.1.3.32	ko:K20454	ko00760,ko01120,map00760,map01120	-	R01355	RC00286,RC01810	ko00000,ko00001,ko01000	-	-	-	PEP_mutase
HKD2_k127_5223036_9	1234364.AMSF01000046_gene1983	1.152e-146	472.0	COG1301@1|root,COG1301@2|Bacteria,1MU0Q@1224|Proteobacteria,1RMEN@1236|Gammaproteobacteria,1X37F@135614|Xanthomonadales	135614|Xanthomonadales	U	Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family	gltP	-	-	ko:K03309	-	-	-	-	ko00000	2.A.23	-	-	SDF
HKD2_k127_5223036_22	1452718.JBOY01000002_gene468	1.099e-43	171.0	COG0589@1|root,COG0589@2|Bacteria,1MVZS@1224|Proteobacteria,1RPAE@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	universal stress protein	ydaA	-	-	ko:K14055	-	-	-	-	ko00000	-	-	-	Usp
HKD2_k127_5223036_13	765912.Thimo_2459	9.766e-118	399.0	COG0645@1|root,COG2187@1|root,COG0645@2|Bacteria,COG2187@2|Bacteria,1MU9M@1224|Proteobacteria,1RPG3@1236|Gammaproteobacteria,1WW4S@135613|Chromatiales	135613|Chromatiales	S	AAA domain	-	-	-	ko:K07028	-	-	-	-	ko00000	-	-	-	AAA_33,APH
HKD2_k127_5223036_7	748247.AZKH_2794	2.494e-159	514.0	COG1488@1|root,COG1488@2|Bacteria,1MV8U@1224|Proteobacteria,2VGZ5@28216|Betaproteobacteria,2KXJ8@206389|Rhodocyclales	206389|Rhodocyclales	H	Nicotinate phosphoribosyltransferase (NAPRTase) family	-	-	6.3.4.21	ko:K00763	ko00760,ko01100,map00760,map01100	-	R01724	RC00033	ko00000,ko00001,ko01000	-	-	-	NAPRTase
HKD2_k127_5223036_19	243233.MCA2761	1.046e-61	222.0	COG1335@1|root,COG1335@2|Bacteria,1MUGW@1224|Proteobacteria,1RZBF@1236|Gammaproteobacteria,1XF7J@135618|Methylococcales	135618|Methylococcales	Q	Isochorismatase family	-	-	3.5.1.19	ko:K08281	ko00760,ko01100,map00760,map01100	-	R01268	RC00100	ko00000,ko00001,ko01000	-	-	-	Isochorismatase
HKD2_k127_5223036_23	472759.Nhal_2244	1.087e-30	124.0	COG1544@1|root,COG1544@2|Bacteria,1RJ55@1224|Proteobacteria,1S5AA@1236|Gammaproteobacteria,1X0WB@135613|Chromatiales	135613|Chromatiales	J	PFAM Cold-shock protein, DNA-binding	-	-	-	-	-	-	-	-	-	-	-	-	CSD,Ribosomal_S30AE
HKD2_k127_5223036_21	396588.Tgr7_1949	5.008e-45	175.0	COG1371@1|root,COG1371@2|Bacteria,1RJU0@1224|Proteobacteria,1S8F6@1236|Gammaproteobacteria,1X1E9@135613|Chromatiales	135613|Chromatiales	S	Archease protein family (MTH1598/TM1083)	-	-	-	-	-	-	-	-	-	-	-	-	Archease
HKD2_k127_5223036_2	1279019.ARQK01000049_gene26	2.49e-217	683.0	COG1690@1|root,COG1690@2|Bacteria,1MUHA@1224|Proteobacteria,1RMXH@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Belongs to the RtcB family	rtcB	-	6.5.1.3	ko:K14415,ko:K18148	ko01501,map01501	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	RtcB
HKD2_k127_5223036_14	102129.Lepto7375DRAFT_2382	1.019e-96	326.0	COG0462@1|root,COG0462@2|Bacteria,1G00F@1117|Cyanobacteria,1H7DZ@1150|Oscillatoriales	1117|Cyanobacteria	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	-	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyl_synth,Pribosyltran_N
HKD2_k127_5223036_17	231434.JQJH01000004_gene554	8.855e-66	237.0	COG2187@1|root,COG2187@2|Bacteria,1MU9M@1224|Proteobacteria,2TQJN@28211|Alphaproteobacteria,3NAZ0@45404|Beijerinckiaceae	28211|Alphaproteobacteria	S	Aminoglycoside phosphotransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5223036_18	886293.Sinac_3851	1.786e-63	229.0	COG1926@1|root,COG1926@2|Bacteria,2J36S@203682|Planctomycetes	203682|Planctomycetes	F	Phosphoribosyl transferase domain	-	-	-	ko:K07100	-	-	-	-	ko00000	-	-	-	Pribosyltran
HKD2_k127_5223036_25	1121015.N789_05695	3.312e-29	121.0	COG3450@1|root,COG3450@2|Bacteria,1N0F7@1224|Proteobacteria,1S92W@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	transcriptional regulator	-	-	-	ko:K06995	-	-	-	-	ko00000	-	-	-	Cupin_3
HKD2_k127_5223036_24	207954.MED92_02529	2.618e-29	129.0	2C5U9@1|root,2Z9NJ@2|Bacteria,1R6D0@1224|Proteobacteria,1S1VT@1236|Gammaproteobacteria,1XREX@135619|Oceanospirillales	135619|Oceanospirillales	S	Bacterial protein of unknown function (Gcw_chp)	-	-	-	-	-	-	-	-	-	-	-	-	Gcw_chp
HKD2_k127_5223036_1	1380394.JADL01000001_gene2803	8.55e-218	686.0	COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,2TQND@28211|Alphaproteobacteria,2JPRX@204441|Rhodospirillales	204441|Rhodospirillales	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.18	ko:K00822	ko00280,ko00410,ko00640,ko01100,map00280,map00410,map00640,map01100	-	R00907,R04187	RC00008,RC00062,RC00160	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_3
HKD2_k127_5223036_16	243365.CV_2021	2.837e-69	240.0	COG0662@1|root,COG1396@1|root,COG0662@2|Bacteria,COG1396@2|Bacteria,1RCYA@1224|Proteobacteria,2WGXA@28216|Betaproteobacteria,2KU4A@206351|Neisseriales	206351|Neisseriales	K	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2,HTH_3
HKD2_k127_5223036_4	760117.JN27_18295	5.664e-213	672.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2VHNV@28216|Betaproteobacteria,472A3@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	Belongs to the aldehyde dehydrogenase family	puuC	-	1.2.1.54,1.2.1.8,1.2.1.99	ko:K00130,ko:K09472,ko:K12254	ko00260,ko00330,ko01100,map00260,map00330,map01100	M00136,M00555	R02549,R02565,R02566,R03177,R07417,R07418	RC00080	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
HKD2_k127_5223036_8	1538295.JY96_07450	3.399e-158	512.0	COG0280@1|root,COG2030@1|root,COG0280@2|Bacteria,COG2030@2|Bacteria,1MWPK@1224|Proteobacteria,2WGKC@28216|Betaproteobacteria,1KJ9Z@119065|unclassified Burkholderiales	28216|Betaproteobacteria	CI	Bifunctional enoyl-CoA hydratase phosphate acetyltransferase	pta	-	2.3.1.19,2.3.1.8	ko:K00625,ko:K00634	ko00430,ko00620,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00650,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00230,R00921,R01174	RC00004,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000	-	-	-	MaoC_dehydratas,PTA_PTB
HKD2_k127_5223036_12	1122132.AQYH01000010_gene4257	6.023e-136	437.0	COG0388@1|root,COG0388@2|Bacteria,1MXG5@1224|Proteobacteria,2TVCS@28211|Alphaproteobacteria,4BDES@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Carbon-nitrogen hydrolase	aguB	-	3.5.1.53	ko:K12251	ko00330,ko01100,map00330,map01100	-	R01152	RC00096	ko00000,ko00001,ko01000	-	-	-	CN_hydrolase
HKD2_k127_5223036_11	1123368.AUIS01000019_gene1225	2.119e-136	449.0	COG0847@1|root,COG0847@2|Bacteria,1MV8Z@1224|Proteobacteria,1T3CM@1236|Gammaproteobacteria,2NDP9@225057|Acidithiobacillales	225057|Acidithiobacillales	L	GIY-YIG type nucleases (URI domain)	-	-	2.7.7.7	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	RNase_T
HKD2_k127_5223036_0	572477.Alvin_2173	1.28e-242	770.0	COG0116@1|root,COG1092@1|root,COG0116@2|Bacteria,COG1092@2|Bacteria,1MUQM@1224|Proteobacteria,1RNMH@1236|Gammaproteobacteria,1WW3V@135613|Chromatiales	135613|Chromatiales	J	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA	rlmL	-	2.1.1.173,2.1.1.264	ko:K12297	-	-	R07234	RC00003	ko00000,ko01000,ko03009	-	-	-	Methyltrans_SAM,THUMP,UPF0020
HKD2_k127_5223036_20	1211114.ALIP01000105_gene1709	7.477e-61	213.0	COG0720@1|root,COG0720@2|Bacteria,1RI4P@1224|Proteobacteria,1S3T6@1236|Gammaproteobacteria,1X6I0@135614|Xanthomonadales	135614|Xanthomonadales	H	synthase	ptpS	-	4.1.2.50,4.2.3.12	ko:K01737	ko00790,ko01100,map00790,map01100	M00842,M00843	R04286,R09959	RC01117,RC02846,RC02847	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	PTPS
HKD2_k127_5223036_6	550540.Fbal_1135	5.802e-160	514.0	COG0665@1|root,COG0665@2|Bacteria,1MVGP@1224|Proteobacteria,1RNJ9@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	oxidoreductase	ordL	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0016491,GO:0044424,GO:0044464,GO:0055114	-	ko:K09471	ko00330,ko01100,map00330,map01100	M00136	R07415	RC00062	ko00000,ko00001,ko00002,ko01000	-	-	-	DAO
HKD2_k127_5223036_10	1279015.KB908462_gene1885	2.806e-144	470.0	COG0174@1|root,COG0174@2|Bacteria,1MU6V@1224|Proteobacteria,1RPNZ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	glutamine synthetase	-	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C
HKD2_k127_5223036_15	1121033.AUCF01000003_gene3316	2.322e-88	301.0	COG2071@1|root,COG2071@2|Bacteria,1MV8E@1224|Proteobacteria,2TSU3@28211|Alphaproteobacteria,2JRWK@204441|Rhodospirillales	204441|Rhodospirillales	S	Peptidase C26	puuD	-	-	ko:K07010	-	-	-	-	ko00000,ko01002	-	-	-	Peptidase_C26
HKD2_k127_5223036_5	349163.Acry_0538	3.633e-195	617.0	COG0174@1|root,COG0174@2|Bacteria,1MU6V@1224|Proteobacteria,2TRCP@28211|Alphaproteobacteria,2JQHA@204441|Rhodospirillales	204441|Rhodospirillales	E	Glutamine synthetase, catalytic domain	-	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C
HKD2_k127_5223036_3	382245.ASA_0173	1.922e-213	671.0	COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,1RNW9@1236|Gammaproteobacteria,1Y586@135624|Aeromonadales	135624|Aeromonadales	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.113	ko:K12256	ko00330,ko01100,map00330,map01100	-	R08714	RC00008,RC00062	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_3
HKD2_k127_5254279_6	1123392.AQWL01000004_gene2603	1.371e-58	208.0	COG0668@1|root,COG0668@2|Bacteria,1N596@1224|Proteobacteria,2VQ9J@28216|Betaproteobacteria,1KSDQ@119069|Hydrogenophilales	119069|Hydrogenophilales	M	Conserved TM helix	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel,TM_helix
HKD2_k127_5254279_2	713586.KB900536_gene2395	1.267e-134	435.0	COG0702@1|root,COG0702@2|Bacteria,1N12V@1224|Proteobacteria,1S93R@1236|Gammaproteobacteria	1236|Gammaproteobacteria	GM	NmrA-like family	-	-	-	-	-	-	-	-	-	-	-	-	NmrA
HKD2_k127_5254279_5	1120999.JONM01000002_gene760	6.97e-63	230.0	COG1120@1|root,COG1120@2|Bacteria,1RDJP@1224|Proteobacteria,2VRTY@28216|Betaproteobacteria,2KU31@206351|Neisseriales	206351|Neisseriales	HP	ATPases associated with a variety of cellular activities	-	-	3.6.3.34	ko:K02013	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14	-	-	ABC_tran
HKD2_k127_5254279_9	640081.Dsui_2000	9.37e-56	218.0	28RZD@1|root,2ZEBA@2|Bacteria,1RBEH@1224|Proteobacteria,2VQVV@28216|Betaproteobacteria,2KVMI@206389|Rhodocyclales	206389|Rhodocyclales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5254279_8	1071679.BG57_14115	4.026e-56	206.0	COG0259@1|root,COG0259@2|Bacteria,1NZUU@1224|Proteobacteria,2VIXW@28216|Betaproteobacteria,1JZMU@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP)	pdxH	-	1.4.3.5	ko:K00275	ko00750,ko01100,ko01120,map00750,map01100,map01120	M00124	R00277,R00278,R01710,R01711	RC00048,RC00116	ko00000,ko00001,ko00002,ko01000	-	-	-	Hemerythrin,PNP_phzG_C,Putative_PNPOx
HKD2_k127_5254279_3	502025.Hoch_6599	3.788e-125	411.0	COG0287@1|root,COG1605@1|root,COG0287@2|Bacteria,COG1605@2|Bacteria,1QA4K@1224|Proteobacteria,42V3B@68525|delta/epsilon subdivisions,2WRIN@28221|Deltaproteobacteria,2YW0I@29|Myxococcales	28221|Deltaproteobacteria	E	Prephenate dehydrogenase chorismate mutase	-	-	1.3.1.12	ko:K00210	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	M00025	R01728	RC00125	ko00000,ko00001,ko00002,ko01000	-	-	-	CM_2,PDH
HKD2_k127_5254279_11	375286.mma_3133	6.717e-39	158.0	COG2199@1|root,COG3159@1|root,COG3159@2|Bacteria,COG3706@2|Bacteria,1R8F2@1224|Proteobacteria,2VJGD@28216|Betaproteobacteria,472P5@75682|Oxalobacteraceae	28216|Betaproteobacteria	T	Protein of unknown function, DUF484	-	-	-	-	-	-	-	-	-	-	-	-	DUF484,GGDEF
HKD2_k127_5254279_4	930169.B5T_04141	6.911e-96	325.0	COG0609@1|root,COG0609@2|Bacteria,1MV9W@1224|Proteobacteria,1RMDF@1236|Gammaproteobacteria,1XIU2@135619|Oceanospirillales	135619|Oceanospirillales	P	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily	-	-	-	ko:K02015	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	FecCD
HKD2_k127_5254279_7	187272.Mlg_0427	3.357e-58	211.0	COG0494@1|root,COG0494@2|Bacteria,1RDGJ@1224|Proteobacteria,1S3PQ@1236|Gammaproteobacteria,1WXC4@135613|Chromatiales	135613|Chromatiales	L	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage	nudH	-	-	ko:K08311	ko03018,map03018	-	R10816	RC00002	ko00000,ko00001,ko01000,ko03019	-	-	-	NUDIX
HKD2_k127_5254279_12	1201293.AKXQ01000003_gene2487	5.14e-13	78.0	2DA4I@1|root,32TUN@2|Bacteria,1N0WK@1224|Proteobacteria,1S6HI@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5254279_10	1008459.TASI_1370	1.117e-51	185.0	COG0316@1|root,COG0316@2|Bacteria,1RHCW@1224|Proteobacteria,2VR2M@28216|Betaproteobacteria,3T3W7@506|Alcaligenaceae	28216|Betaproteobacteria	C	Required for insertion of 4Fe-4S clusters	erpA	-	-	ko:K15724	-	-	-	-	ko00000	-	-	-	Fe-S_biosyn
HKD2_k127_5254279_1	396588.Tgr7_2467	5.796e-154	501.0	COG0248@1|root,COG0248@2|Bacteria,1MV35@1224|Proteobacteria,1RN3V@1236|Gammaproteobacteria,1WWTY@135613|Chromatiales	135613|Chromatiales	FP	Belongs to the GppA Ppx family	-	-	3.6.1.11,3.6.1.40	ko:K01524	ko00230,map00230	-	R03409	RC00002	ko00000,ko00001,ko01000	-	-	-	Ppx-GppA
HKD2_k127_5254279_0	1122604.JONR01000026_gene3009	2.833e-240	758.0	COG0855@1|root,COG0855@2|Bacteria,1MUM3@1224|Proteobacteria,1RNRX@1236|Gammaproteobacteria,1X3E8@135614|Xanthomonadales	135614|Xanthomonadales	P	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)	ppk	-	2.7.4.1	ko:K00937	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PP_kinase,PP_kinase_C,PP_kinase_N
HKD2_k127_5263757_3	1380394.JADL01000002_gene1193	7.257e-122	406.0	COG1014@1|root,COG4231@1|root,COG1014@2|Bacteria,COG4231@2|Bacteria,1MUKS@1224|Proteobacteria,2TSHH@28211|Alphaproteobacteria,2JQ67@204441|Rhodospirillales	204441|Rhodospirillales	C	COG4231 Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits	-	-	1.2.7.8	ko:K04090	-	-	-	-	br01601,ko00000,ko01000	-	-	-	POR,TPP_enzyme_C
HKD2_k127_5263757_1	1366050.N234_31955	1.619e-156	507.0	COG0534@1|root,COG0534@2|Bacteria,1MVRV@1224|Proteobacteria,2VKQ7@28216|Betaproteobacteria,1KBPM@119060|Burkholderiaceae	28216|Betaproteobacteria	V	Polysaccharide biosynthesis C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	MatE
HKD2_k127_5263757_8	1122604.JONR01000040_gene4032	7.547e-55	214.0	COG0426@1|root,COG0426@2|Bacteria,1N4CQ@1224|Proteobacteria,1SC4U@1236|Gammaproteobacteria,1XDEF@135614|Xanthomonadales	135614|Xanthomonadales	C	NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
HKD2_k127_5263757_11	1120973.AQXL01000128_gene2783	1.461e-41	163.0	COG0300@1|root,COG0300@2|Bacteria,1TSJ3@1239|Firmicutes,4HDU5@91061|Bacilli,279ZC@186823|Alicyclobacillaceae	91061|Bacilli	S	KR domain	yqjQ	-	-	ko:K07124	-	-	-	-	ko00000	-	-	-	adh_short
HKD2_k127_5263757_6	882082.SaccyDRAFT_3006	6.035e-77	267.0	COG1024@1|root,COG1024@2|Bacteria,2GJG7@201174|Actinobacteria,4E086@85010|Pseudonocardiales	201174|Actinobacteria	I	Enoyl-CoA hydratase carnithine racemase	echA21	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005777,GO:0042579,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464	4.2.1.17	ko:K01692	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
HKD2_k127_5263757_0	1095769.CAHF01000001_gene3559	3.845e-266	830.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2VI0I@28216|Betaproteobacteria,473Q4@75682|Oxalobacteraceae	28216|Betaproteobacteria	IQ	AMP-binding enzyme C-terminal domain	fadD	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
HKD2_k127_5263757_4	1384056.N787_05635	1.728e-119	391.0	COG0652@1|root,COG0652@2|Bacteria,1QCY4@1224|Proteobacteria,1RY8D@1236|Gammaproteobacteria,1X4AR@135614|Xanthomonadales	135614|Xanthomonadales	O	peptidyl-prolyl cis-trans isomerase	-	-	5.2.1.8	ko:K01802	-	-	-	-	ko00000,ko01000	-	-	-	Pro_isomerase
HKD2_k127_5263757_9	1121385.AQXW01000004_gene2650	1.476e-48	193.0	COG3340@1|root,COG3340@2|Bacteria,2IGG2@201174|Actinobacteria	201174|Actinobacteria	E	Belongs to the peptidase S51 family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S51
HKD2_k127_5263757_5	1172188.KB911820_gene2095	1.341e-104	361.0	COG2382@1|root,COG2382@2|Bacteria,2I844@201174|Actinobacteria,4FE3S@85021|Intrasporangiaceae	201174|Actinobacteria	P	Putative esterase	-	-	-	ko:K07214	-	-	-	-	ko00000	-	-	-	DUF3327,Esterase
HKD2_k127_5263757_2	710696.Intca_3443	2.191e-123	408.0	COG0189@1|root,COG0189@2|Bacteria,2I5WV@201174|Actinobacteria,4FF3F@85021|Intrasporangiaceae	201174|Actinobacteria	HJ	ligase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5263757_7	1172188.KB911820_gene2094	1.064e-76	276.0	COG4947@1|root,COG4947@2|Bacteria,2I9H9@201174|Actinobacteria,4FFF6@85021|Intrasporangiaceae	201174|Actinobacteria	S	Putative esterase	-	-	-	-	-	-	-	-	-	-	-	-	Esterase
HKD2_k127_5263757_12	765910.MARPU_04685	3.965e-14	76.0	2A022@1|root,30N4C@2|Bacteria,1PU9F@1224|Proteobacteria,1SCMU@1236|Gammaproteobacteria,1WYYW@135613|Chromatiales	135613|Chromatiales	S	Domain of unknown function (DUF1840)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1840
HKD2_k127_5263757_13	665942.HMPREF1022_01740	9.544e-06	57.0	COG0348@1|root,COG0348@2|Bacteria,1R4WT@1224|Proteobacteria,42NQI@68525|delta/epsilon subdivisions,2WKGR@28221|Deltaproteobacteria,2M7YW@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	PFAM 4Fe-4S ferredoxin iron-sulfur binding	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_5,Fer4_9
HKD2_k127_5263757_10	929556.Solca_3998	9.548e-47	181.0	COG3324@1|root,COG3324@2|Bacteria,4NZ00@976|Bacteroidetes	976|Bacteroidetes	E	translation initiation factor activity	-	-	-	ko:K06996	-	-	-	-	ko00000	-	-	-	Glyoxalase
HKD2_k127_5292406_7	1449049.JONW01000006_gene2883	1.169e-12	72.0	COG0385@1|root,COG0385@2|Bacteria,1N9IH@1224|Proteobacteria	1224|Proteobacteria	S	Bile acid	-	-	-	ko:K03453	-	-	-	-	ko00000	2.A.28	-	-	SBF
HKD2_k127_5292406_6	491916.RHECIAT_CH0001784	1.599e-39	155.0	COG1814@1|root,COG1814@2|Bacteria,1R469@1224|Proteobacteria,2U4KR@28211|Alphaproteobacteria,4BCYP@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	VIT family	-	-	-	-	-	-	-	-	-	-	-	-	VIT1
HKD2_k127_5292406_4	631362.Thi970DRAFT_00381	1.21e-58	217.0	COG2207@1|root,COG2207@2|Bacteria,1MX23@1224|Proteobacteria,1RRXM@1236|Gammaproteobacteria,1WYGD@135613|Chromatiales	135613|Chromatiales	K	PFAM Bacterial regulatory helix-turn-helix proteins, AraC family	-	-	-	-	-	-	-	-	-	-	-	-	Arabinose_bd,HTH_18
HKD2_k127_5292406_0	234267.Acid_4974	5.094e-240	752.0	COG1760@1|root,COG1760@2|Bacteria,3Y420@57723|Acidobacteria	57723|Acidobacteria	E	serine dehydratase beta chain	-	-	4.3.1.17	ko:K01752	ko00260,ko00270,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00270,map01100,map01110,map01130,map01200,map01230	-	R00220,R00590	RC00331,RC02600	ko00000,ko00001,ko01000	-	-	-	SDH_alpha,SDH_beta
HKD2_k127_5292406_2	1449049.JONW01000005_gene1183	2.868e-172	550.0	COG2271@1|root,COG2271@2|Bacteria,1RGKJ@1224|Proteobacteria,2TV2F@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	PFAM major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD2_k127_5292406_3	1267534.KB906761_gene1194	9.266e-128	435.0	COG0280@1|root,COG0280@2|Bacteria,3Y4QI@57723|Acidobacteria	57723|Acidobacteria	C	Phosphate acetyl/butaryl transferase	-	-	2.3.1.8	ko:K00625	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00230,R00921	RC00004,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000	-	-	-	PTA_PTB
HKD2_k127_5292406_1	1267534.KB906761_gene1193	8.667e-178	565.0	COG0282@1|root,COG0282@2|Bacteria,3Y3Y4@57723|Acidobacteria,2JI6D@204432|Acidobacteriia	57723|Acidobacteria	C	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction	ackA	-	2.7.2.1	ko:K00925	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00315,R01353	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetate_kinase
HKD2_k127_5292406_5	1348663.KCH_28830	6.121e-40	151.0	COG1882@1|root,COG1882@2|Bacteria,2GTTT@201174|Actinobacteria,2M1R1@2063|Kitasatospora	201174|Actinobacteria	C	Pyruvate formate lyase-like	pflB	-	2.3.1.54	ko:K00656	ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120	-	R00212,R06987	RC00004,RC01181,RC02742,RC02833	ko00000,ko00001,ko01000	-	-	-	Gly_radical,PFL-like
HKD2_k127_5307441_9	1260251.SPISAL_08215	1.025e-50	180.0	COG1158@1|root,COG1158@2|Bacteria,1MUCF@1224|Proteobacteria,1RP95@1236|Gammaproteobacteria,1WW22@135613|Chromatiales	135613|Chromatiales	K	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template	rho	-	-	ko:K03628	ko03018,map03018	-	-	-	ko00000,ko00001,ko03019,ko03021	-	-	-	ATP-synt_ab,Rho_N,Rho_RNA_bind
HKD2_k127_5307441_7	358220.C380_16725	3.009e-80	281.0	COG0697@1|root,COG0697@2|Bacteria,1MXPW@1224|Proteobacteria,2VNUP@28216|Betaproteobacteria,4ACX6@80864|Comamonadaceae	28216|Betaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HKD2_k127_5307441_4	1121861.KB899920_gene2862	8.96e-133	430.0	COG0451@1|root,COG0451@2|Bacteria,1MVE4@1224|Proteobacteria,2TQJI@28211|Alphaproteobacteria,2JR70@204441|Rhodospirillales	204441|Rhodospirillales	G	Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose	hldD	-	5.1.3.20	ko:K03274	ko00540,ko01100,map00540,map01100	M00064	R05176	RC01291	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Epimerase
HKD2_k127_5307441_13	637389.Acaty_c2233	3.297e-41	164.0	COG0241@1|root,COG0241@2|Bacteria,1RDGR@1224|Proteobacteria,1S3UD@1236|Gammaproteobacteria,2NBS8@225057|Acidithiobacillales	225057|Acidithiobacillales	E	D,D-heptose 1,7-bisphosphate phosphatase	-	-	3.1.3.82,3.1.3.83	ko:K03273	ko00540,ko01100,map00540,map01100	M00064	R05647,R09771	RC00017	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hydrolase_like
HKD2_k127_5307441_12	526227.Mesil_0237	6.166e-48	179.0	COG0279@1|root,COG0279@2|Bacteria,1WMGK@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	G	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate	gmhA	-	5.3.1.28	ko:K03271	ko00540,ko01100,map00540,map01100	M00064	R05645,R09768,R09769	RC00434	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	SIS_2
HKD2_k127_5307441_6	401053.AciPR4_1391	1.314e-114	395.0	COG0615@1|root,COG2870@1|root,COG0615@2|Bacteria,COG2870@2|Bacteria,3Y303@57723|Acidobacteria,2JINA@204432|Acidobacteriia	204432|Acidobacteriia	H	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose	hldE	-	2.7.1.167,2.7.7.70	ko:K03272	ko00540,ko01100,map00540,map01100	M00064	R05644,R05646	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CTP_transf_like,PfkB
HKD2_k127_5307441_14	1236517.BAKO01000029_gene360	5.557e-31	142.0	COG1215@1|root,COG1215@2|Bacteria,4NFI8@976|Bacteroidetes,2FQAZ@200643|Bacteroidia	976|Bacteroidetes	M	Psort location CytoplasmicMembrane, score 10.00	-	-	-	-	-	-	-	-	-	-	-	-	GT87
HKD2_k127_5307441_8	1123393.KB891317_gene2260	1.25e-76	273.0	COG3394@1|root,COG3394@2|Bacteria,1MX3P@1224|Proteobacteria,2W9EU@28216|Betaproteobacteria,1KTD9@119069|Hydrogenophilales	119069|Hydrogenophilales	G	YdjC-like protein	-	-	-	-	-	-	-	-	-	-	-	-	YdjC
HKD2_k127_5307441_1	1123393.KB891317_gene2258	4.293e-169	556.0	COG1807@1|root,COG1807@2|Bacteria,1NMIZ@1224|Proteobacteria,2VMHK@28216|Betaproteobacteria,1KTF4@119069|Hydrogenophilales	119069|Hydrogenophilales	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HKD2_k127_5307441_3	1123393.KB891317_gene2257	7.879e-140	452.0	COG0463@1|root,COG0463@2|Bacteria,1MWE5@1224|Proteobacteria,2VIY2@28216|Betaproteobacteria,1KT2X@119069|Hydrogenophilales	119069|Hydrogenophilales	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HKD2_k127_5307441_10	1286106.MPL1_00887	1.471e-50	200.0	COG1807@1|root,COG1807@2|Bacteria	2|Bacteria	M	4-amino-4-deoxy-L-arabinose transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HKD2_k127_5307441_11	1033802.SSPSH_000596	1.853e-49	195.0	COG0859@1|root,COG0859@2|Bacteria,1N2DA@1224|Proteobacteria,1SBNA@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	glycosyl transferase family	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_9
HKD2_k127_5307441_2	95619.PM1_0204230	2.324e-167	537.0	COG0151@1|root,COG0151@2|Bacteria,1MUAH@1224|Proteobacteria,1RNS4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	F	Belongs to the GARS family	purD	GO:0000166,GO:0003674,GO:0003824,GO:0004637,GO:0005488,GO:0005524,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016874,GO:0016879,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0050896,GO:0051716,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.3.2.6,6.3.4.13	ko:K01945,ko:K13713	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144,R04591	RC00064,RC00090,RC00162,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	iECNA114_1301.ECNA114_3417,iECSF_1327.ECSF_3859,iJN746.PP_4823,iPC815.YPO3729	GARS_A,GARS_C,GARS_N
HKD2_k127_5307441_0	745411.B3C1_06173	9.641e-222	702.0	COG0138@1|root,COG0138@2|Bacteria,1MUDQ@1224|Proteobacteria,1RMWS@1236|Gammaproteobacteria,1J4DF@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	F	Bifunctional purine biosynthesis protein PurH	purH	GO:0003674,GO:0003824,GO:0004643,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016741,GO:0016742,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iEcHS_1320.EcHS_A4240,iPC815.YPO3728	AICARFT_IMPCHas,MGS
HKD2_k127_5307441_15	519989.ECTPHS_06012	1.472e-20	96.0	COG2901@1|root,COG2901@2|Bacteria,1N7MJ@1224|Proteobacteria,1SD35@1236|Gammaproteobacteria,1WZ4D@135613|Chromatiales	135613|Chromatiales	KL	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters	-	-	-	ko:K03557	ko05111,map05111	-	-	-	ko00000,ko00001,ko03000,ko03036,ko03400	-	-	-	HTH_8
HKD2_k127_5307441_5	1442599.JAAN01000035_gene665	1.099e-122	409.0	COG0042@1|root,COG0042@2|Bacteria,1MV5V@1224|Proteobacteria,1RMJP@1236|Gammaproteobacteria,1X3G9@135614|Xanthomonadales	135614|Xanthomonadales	J	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines	dusB	-	-	ko:K05540	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Dus
HKD2_k127_5307441_16	396588.Tgr7_0364	2.949e-16	84.0	COG1273@1|root,COG1273@2|Bacteria,1MWCU@1224|Proteobacteria,1S892@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function (DUF3426)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3426,zinc_ribbon_5
HKD2_k127_5434148_8	478741.JAFS01000001_gene2071	9.195e-25	111.0	COG1309@1|root,COG1309@2|Bacteria,46T9V@74201|Verrucomicrobia	74201|Verrucomicrobia	K	WHG domain	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N,WHG
HKD2_k127_5434148_5	316057.RPD_3316	2.817e-36	155.0	COG2030@1|root,COG2030@2|Bacteria,1RFHT@1224|Proteobacteria,2UKBG@28211|Alphaproteobacteria,3K446@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	PFAM MaoC domain protein dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydratas
HKD2_k127_5434148_1	580332.Slit_2572	9.645e-97	321.0	arCOG09454@1|root,30G4A@2|Bacteria,1N61J@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5434148_6	1123393.KB891317_gene2473	4.124e-32	144.0	2EMF3@1|root,2ZKNW@2|Bacteria,1RAZA@1224|Proteobacteria,2VQE2@28216|Betaproteobacteria	28216|Betaproteobacteria	S	PEP-CTERM motif	-	-	-	-	-	-	-	-	-	-	-	-	VPEP
HKD2_k127_5434148_11	1340493.JNIF01000003_gene4150	0.0001161	55.0	COG1470@1|root,COG4625@1|root,COG1470@2|Bacteria,COG4625@2|Bacteria,3Y354@57723|Acidobacteria	57723|Acidobacteria	M	PKD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	He_PIG
HKD2_k127_5434148_10	202698.XP_007386143.1	3.167e-06	60.0	2CZ05@1|root,2S7IZ@2759|Eukaryota,39NTD@33154|Opisthokonta	33154|Opisthokonta	S	Putative ephrin-receptor like	-	-	-	-	-	-	-	-	-	-	-	-	Ephrin_rec_like
HKD2_k127_5434148_2	1207063.P24_01480	1.666e-91	314.0	COG3213@1|root,COG3213@2|Bacteria,1MUJK@1224|Proteobacteria,2TSQ2@28211|Alphaproteobacteria,2JRD2@204441|Rhodospirillales	204441|Rhodospirillales	P	protein involved in response to NO	-	-	-	ko:K07234	-	-	-	-	ko00000	-	-	-	NnrS
HKD2_k127_5434148_0	1366050.N234_35540	2.968e-189	601.0	COG1858@1|root,COG1858@2|Bacteria,1N4E1@1224|Proteobacteria,2VVJQ@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C
HKD2_k127_5434148_3	640510.BC1001_5248	4.102e-83	282.0	COG1595@1|root,COG1595@2|Bacteria,1MX7T@1224|Proteobacteria,2VR5K@28216|Betaproteobacteria,1K265@119060|Burkholderiaceae	28216|Betaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD2_k127_5434148_7	342113.DM82_3225	2.499e-26	112.0	COG3794@1|root,COG3794@2|Bacteria,1MZHR@1224|Proteobacteria,2WFFZ@28216|Betaproteobacteria,1KI1J@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Copper binding proteins, plastocyanin/azurin family	-	-	-	-	-	-	-	-	-	-	-	-	Cupredoxin_1
HKD2_k127_5434148_4	640510.BC1001_5250	8.578e-68	236.0	COG3652@1|root,COG3652@2|Bacteria,1RDPI@1224|Proteobacteria,2VRQA@28216|Betaproteobacteria,1K202@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Domain of unknown function (DUF4142)	-	-	-	ko:K08995	-	-	-	-	ko00000	-	-	-	DUF4142
HKD2_k127_5434148_9	1101191.KI912577_gene3264	1.702e-13	80.0	COG1807@1|root,COG1807@2|Bacteria,1NMIZ@1224|Proteobacteria,2TRS4@28211|Alphaproteobacteria,1JTEY@119045|Methylobacteriaceae	28211|Alphaproteobacteria	M	PFAM glycosyl transferase family 39	MA20_30100	-	-	-	-	-	-	-	-	-	-	-	PMT,PMT_2
HKD2_k127_5450465_1	1120956.JHZK01000010_gene2780	2.394e-116	378.0	COG0404@1|root,COG0665@1|root,COG0404@2|Bacteria,COG0665@2|Bacteria,1MUXJ@1224|Proteobacteria,2TRGS@28211|Alphaproteobacteria,1JN98@119043|Rhodobiaceae	28211|Alphaproteobacteria	E	FAD dependent oxidoreductase central domain	-	-	1.5.8.4	ko:K00315	ko00260,ko01100,map00260,map01100	-	R01565	RC00181	ko00000,ko00001,ko01000	-	-	-	DAO,FAO_M,GCV_T,GCV_T_C
HKD2_k127_5450465_0	1287116.X734_25670	1.044e-167	550.0	COG5598@1|root,COG5598@2|Bacteria,1NQMY@1224|Proteobacteria,2U0NX@28211|Alphaproteobacteria,43R7V@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	H	Trimethylamine methyltransferase (MTTB)	-	-	2.1.1.250	ko:K14083	ko00680,ko01120,ko01200,map00680,map01120,map01200	M00563	R09124,R10016	RC00035,RC00732,RC01144,RC02984	ko00000,ko00001,ko00002,ko01000	-	-	-	MTTB
HKD2_k127_5450465_2	492774.JQMB01000009_gene3239	9.122e-86	295.0	COG0583@1|root,COG0583@2|Bacteria,1RKAT@1224|Proteobacteria,2UB5R@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	LysR substrate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HKD2_k127_5450465_3	983920.Y88_0697	6.265e-43	163.0	COG4774@1|root,COG4774@2|Bacteria,1QXWU@1224|Proteobacteria,2TZ8R@28211|Alphaproteobacteria,2KERA@204457|Sphingomonadales	204457|Sphingomonadales	P	TonB dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
HKD2_k127_5556466_0	1265313.HRUBRA_01699	4.188e-193	617.0	COG4993@1|root,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,1RN5D@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	PQQ,PQQ_2
HKD2_k127_5556466_4	565045.NOR51B_2579	7.272e-18	87.0	COG1359@1|root,COG1359@2|Bacteria,1PVN7@1224|Proteobacteria,1SG5I@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Antibiotic biosynthesis monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	ABM
HKD2_k127_5556466_2	1432055.GLUCORHAEAF1_02955	1.946e-124	415.0	COG0022@1|root,COG0022@2|Bacteria,1R8KB@1224|Proteobacteria,2TRFK@28211|Alphaproteobacteria,2JVBR@204441|Rhodospirillales	204441|Rhodospirillales	C	Transketolase, pyrimidine binding domain	-	-	-	ko:K21417	-	-	-	-	ko00000,ko01000	-	-	-	Transket_pyr,Transketolase_C
HKD2_k127_5556466_1	1211112.ALJC01000073_gene3212	1.459e-127	417.0	COG1071@1|root,COG1071@2|Bacteria,1MU5R@1224|Proteobacteria,1RWHU@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	dehydrogenase e1 component	acoA	-	-	ko:K21416	-	-	-	-	ko00000,ko01000	-	-	-	E1_dh
HKD2_k127_5556466_3	158500.BV97_02810	5.667e-103	344.0	COG0006@1|root,COG0006@2|Bacteria,1R9IK@1224|Proteobacteria,2UZCT@28211|Alphaproteobacteria,2K8MH@204457|Sphingomonadales	204457|Sphingomonadales	E	Creatinase/Prolidase N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Creatinase_N,Peptidase_M24
HKD2_k127_5586835_3	404589.Anae109_3152	1.046e-16	83.0	2C0SQ@1|root,33DUT@2|Bacteria,1R7NR@1224|Proteobacteria,4319Q@68525|delta/epsilon subdivisions,2WW9H@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5586835_1	1265505.ATUG01000001_gene3625	1.838e-81	278.0	COG0745@1|root,COG0745@2|Bacteria,1MU3A@1224|Proteobacteria,42S73@68525|delta/epsilon subdivisions,2WNPE@28221|Deltaproteobacteria,2MPTJ@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
HKD2_k127_5586835_0	1121396.KB893080_gene898	8.856e-84	304.0	COG0642@1|root,COG2205@2|Bacteria,1QUJ7@1224|Proteobacteria,43BJF@68525|delta/epsilon subdivisions,2WU4G@28221|Deltaproteobacteria,2MMQM@213118|Desulfobacterales	28221|Deltaproteobacteria	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
HKD2_k127_5586835_4	472759.Nhal_1698	4.516e-05	53.0	29FX1@1|root,34453@2|Bacteria,1P3CX@1224|Proteobacteria,1SVJS@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5586835_2	686340.Metal_3994	2.652e-69	241.0	COG0486@1|root,COG0486@2|Bacteria,1MUCQ@1224|Proteobacteria,1RN5S@1236|Gammaproteobacteria,1XE1Y@135618|Methylococcales	135618|Methylococcales	J	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34	mnmE	-	-	ko:K03650	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko01000,ko03016	-	-	-	MMR_HSR1,MnmE_helical,TrmE_N
HKD2_k127_5614860_1	864051.BurJ1DRAFT_2886	1.087e-86	288.0	COG1350@1|root,COG1350@2|Bacteria,1N07Y@1224|Proteobacteria,2VJ62@28216|Betaproteobacteria,1KN36@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	-	-	4.2.1.20	ko:K01696,ko:K06001	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HKD2_k127_5614860_0	589865.DaAHT2_0989	3.335e-150	485.0	COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,42MGZ@68525|delta/epsilon subdivisions,2WIY6@28221|Deltaproteobacteria,2MHSV@213118|Desulfobacterales	28221|Deltaproteobacteria	L	DEAD DEAH box helicase	-	-	3.6.4.13	ko:K11927	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DEAD,Helicase_C
HKD2_k127_5614860_2	1230476.C207_05220	1.239e-48	179.0	COG0583@1|root,COG0583@2|Bacteria,1MW16@1224|Proteobacteria,2TRIG@28211|Alphaproteobacteria,3JRV7@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	Bacterial regulatory helix-turn-helix protein, lysR family	MA20_14610	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HKD2_k127_6020901_7	666685.R2APBS1_2716	2.411e-91	309.0	COG1946@1|root,COG1946@2|Bacteria,1MV9R@1224|Proteobacteria,1RPFI@1236|Gammaproteobacteria,1X38E@135614|Xanthomonadales	135614|Xanthomonadales	I	Acyl-CoA thioesterase	tesB	-	-	ko:K10805	ko01040,map01040	-	-	-	ko00000,ko00001,ko01000,ko01004	-	-	-	4HBT_3
HKD2_k127_6020901_2	1123256.KB907925_gene1180	3.486e-179	599.0	COG2982@1|root,COG2982@2|Bacteria,1MUME@1224|Proteobacteria,1RNPC@1236|Gammaproteobacteria,1X4JW@135614|Xanthomonadales	135614|Xanthomonadales	M	Domain of Unknown Function (DUF748)	-	-	-	-	-	-	-	-	-	-	-	-	DUF748
HKD2_k127_6020901_4	331869.BAL199_20420	4.547e-156	513.0	COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2TRYI@28211|Alphaproteobacteria,4BPTY@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	FAD linked oxidases, C-terminal domain	MA20_27310	-	-	-	-	-	-	-	-	-	-	-	FAD-oxidase_C,FAD_binding_4
HKD2_k127_6020901_9	795666.MW7_0646	1.198e-47	186.0	COG2764@1|root,COG2764@2|Bacteria,1RF5T@1224|Proteobacteria,2VRX6@28216|Betaproteobacteria,1K7TG@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Glyoxalase bleomycin resistance protein dioxygenase	-	-	-	ko:K04750	-	-	-	-	ko00000	-	-	-	Glyoxalase
HKD2_k127_6020901_8	926560.KE387026_gene4246	2.753e-91	304.0	COG0288@1|root,COG0288@2|Bacteria,1WKSX@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	P	Reversible hydration of carbon dioxide	-	-	4.2.1.1	ko:K01673	ko00910,map00910	-	R00132,R10092	RC02807	ko00000,ko00001,ko01000	-	-	-	Pro_CA
HKD2_k127_6020901_12	1123517.JOMR01000001_gene993	5.262e-26	117.0	COG0664@1|root,COG0664@2|Bacteria,1NBRS@1224|Proteobacteria,1T0IJ@1236|Gammaproteobacteria,462MB@72273|Thiotrichales	72273|Thiotrichales	T	Cyclic nucleotide-monophosphate binding domain	-	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	cNMP_binding
HKD2_k127_6020901_1	713587.THITH_04325	2.063e-186	593.0	COG0415@1|root,COG0415@2|Bacteria,1MV9Y@1224|Proteobacteria,1RNGJ@1236|Gammaproteobacteria,1WXQX@135613|Chromatiales	135613|Chromatiales	L	DNA photolyase	-	-	4.1.99.3	ko:K01669	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_photolyase,FAD_binding_7
HKD2_k127_6020901_6	261292.Nit79A3_2096	1.679e-130	423.0	COG0501@1|root,COG0501@2|Bacteria,1MUV4@1224|Proteobacteria,2VIVB@28216|Betaproteobacteria,372AH@32003|Nitrosomonadales	28216|Betaproteobacteria	O	Belongs to the peptidase M48B family	htpX	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
HKD2_k127_6020901_11	661478.OP10G_1817	2.186e-29	123.0	COG1846@1|root,COG1846@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24,MarR_2
HKD2_k127_6020901_13	1121017.AUFG01000028_gene566	2.973e-15	86.0	COG5607@1|root,COG5607@2|Bacteria,2GJZH@201174|Actinobacteria,4FGGJ@85021|Intrasporangiaceae	201174|Actinobacteria	S	CHAD	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	CHAD,CYTH
HKD2_k127_6020901_10	305700.B447_12639	1.059e-29	125.0	COG0045@1|root,COG1042@1|root,COG1247@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,COG1247@2|Bacteria,1MW98@1224|Proteobacteria,2VI9R@28216|Betaproteobacteria,2KUDI@206389|Rhodocyclales	206389|Rhodocyclales	CM	Acyl-CoA synthetase (NDP forming)	yfiQ	-	-	ko:K09181	-	-	-	-	ko00000	-	-	-	ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig
HKD2_k127_6020901_14	1283300.ATXB01000001_gene1279	2.8e-10	65.0	2E600@1|root,330PC@2|Bacteria,1N9V9@1224|Proteobacteria,1SHAU@1236|Gammaproteobacteria,1XFBV@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6020901_0	1301098.PKB_0514	5.357e-227	717.0	COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,1RNV1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	acyl-CoA dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N
HKD2_k127_6020901_5	1089552.KI911559_gene771	1.421e-148	481.0	COG0263@1|root,COG0263@2|Bacteria,1MUBG@1224|Proteobacteria,2TRKB@28211|Alphaproteobacteria,2JPD3@204441|Rhodospirillales	204441|Rhodospirillales	E	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate	proB	-	2.7.2.11	ko:K00931	ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230	M00015	R00239	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,PUA
HKD2_k127_6020901_3	1333998.M2A_0825	1.069e-171	557.0	COG0014@1|root,COG0014@2|Bacteria,1MUGJ@1224|Proteobacteria,2TS83@28211|Alphaproteobacteria,4BPBI@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	E	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate	proA	GO:0003674,GO:0003824,GO:0004350,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0055114	1.2.1.41	ko:K00147	ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230	M00015	R03313	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
HKD2_k127_6020901_15	465515.Mlut_07990	1.175e-06	55.0	COG0476@1|root,COG0476@2|Bacteria,2GJB6@201174|Actinobacteria,1W898@1268|Micrococcaceae	201174|Actinobacteria	H	The proteins in this cluster have high sequence similarity to MoeB and are possibly involved in the synthesis of molybdopterin, but there has been no biochemical or physiological characterization. There is also no genetic linkage to other molybdopterin cofactor synthesis proteins. These proteins are	thiF	-	2.7.7.80,2.8.1.11	ko:K21029,ko:K21147	ko04122,map04122	-	R07459,R07461	RC00043	ko00000,ko00001,ko01000	-	-	-	Rhodanese,ThiF
HKD2_k127_6201525_3	1123487.KB892863_gene1873	8.318e-32	126.0	COG0583@1|root,COG0583@2|Bacteria,1MW16@1224|Proteobacteria,2VK4X@28216|Betaproteobacteria,2KW3S@206389|Rhodocyclales	206389|Rhodocyclales	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HKD2_k127_6201525_2	1336243.JAEA01000003_gene2396	1.146e-41	157.0	COG2259@1|root,COG2259@2|Bacteria,1N06A@1224|Proteobacteria,2U6MK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	PFAM DoxX family protein	-	-	-	ko:K15977	-	-	-	-	ko00000	-	-	-	DoxX
HKD2_k127_6201525_1	1123487.KB892863_gene1874	1.711e-84	287.0	COG3384@1|root,COG3384@2|Bacteria,1MXJZ@1224|Proteobacteria,2VIC3@28216|Betaproteobacteria,2KVN7@206389|Rhodocyclales	206389|Rhodocyclales	S	Catalytic LigB subunit of aromatic ring-opening dioxygenase	ygiD	-	-	ko:K15777	ko00965,map00965	-	R08836	RC00387	ko00000,ko00001,ko01000	-	-	-	LigB
HKD2_k127_6201525_0	1300345.LF41_1697	8.194e-109	359.0	COG0624@1|root,COG0624@2|Bacteria,1MWJS@1224|Proteobacteria,1RZXV@1236|Gammaproteobacteria,1X2ZT@135614|Xanthomonadales	135614|Xanthomonadales	E	Acetylornithine deacetylase Succinyl-diaminopimelate	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
HKD2_k127_6400159_15	1121887.AUDK01000012_gene1633	0.0001915	51.0	COG3209@1|root,COG3209@2|Bacteria,4NGJF@976|Bacteroidetes,1HYT1@117743|Flavobacteriia,2NTE8@237|Flavobacterium	976|Bacteroidetes	M	RHS repeat-associated core domain protein	-	-	-	-	-	-	-	-	-	-	-	-	RHS_repeat,SpvB,VCBS
HKD2_k127_6400159_0	1123257.AUFV01000014_gene3436	9.877e-281	880.0	COG2010@1|root,COG4993@1|root,COG2010@2|Bacteria,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,1RN5D@1236|Gammaproteobacteria,1X586@135614|Xanthomonadales	135614|Xanthomonadales	CG	PQQ-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3,PQQ,PQQ_2
HKD2_k127_6400159_5	1149133.ppKF707_5907	6.47e-149	479.0	COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,1RN6J@1236|Gammaproteobacteria,1YHS4@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	E	Pyridoxal-phosphate dependent enzyme	cysK	-	2.5.1.47,4.2.1.22	ko:K01697,ko:K01738	ko00260,ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00260,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021,M00035,M00338	R00891,R00897,R01290,R03601,R04859,R04942	RC00020,RC00056,RC00069,RC00256,RC00489,RC01246,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HKD2_k127_6400159_12	1223410.KN050846_gene2830	2.202e-08	64.0	2E3AK@1|root,320TI@2|Bacteria,4NRX2@976|Bacteroidetes,1I3SJ@117743|Flavobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6400159_6	1218084.BBJK01000038_gene3567	4.459e-102	353.0	COG4916@1|root,COG4916@2|Bacteria,1RBBR@1224|Proteobacteria,2VTPZ@28216|Betaproteobacteria	28216|Betaproteobacteria	S	TIR domain	-	-	-	-	-	-	-	-	-	-	-	-	SIR2_2,TIR_2
HKD2_k127_6400159_7	69042.WH5701_09204	3.249e-89	332.0	COG1672@1|root,COG3772@1|root,COG1672@2|Bacteria,COG3772@2|Bacteria,1GFH6@1117|Cyanobacteria	1117|Cyanobacteria	S	Phage lysozyme	-	-	-	-	-	-	-	-	-	-	-	-	Phage_lysozyme
HKD2_k127_6400159_10	713586.KB900536_gene2406	1.314e-16	90.0	COG3087@1|root,COG3087@2|Bacteria,1RCC0@1224|Proteobacteria,1SBGX@1236|Gammaproteobacteria	1236|Gammaproteobacteria	D	Sporulation related domain	-	-	-	-	-	-	-	-	-	-	-	-	SPOR
HKD2_k127_6400159_2	713586.KB900536_gene2407	1.598e-233	737.0	COG0018@1|root,COG0018@2|Bacteria,1MU4J@1224|Proteobacteria,1RPRC@1236|Gammaproteobacteria,1WVYV@135613|Chromatiales	135613|Chromatiales	J	Arginyl-tRNA synthetase	argS	-	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
HKD2_k127_6400159_8	1122194.AUHU01000016_gene1860	1.483e-53	203.0	2DKFZ@1|root,309D6@2|Bacteria,1REQQ@1224|Proteobacteria,1S796@1236|Gammaproteobacteria,466PI@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Domain of unknown function (DUF4382)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4382
HKD2_k127_6400159_3	187272.Mlg_2496	6.302e-224	715.0	COG1198@1|root,COG1198@2|Bacteria,1MUUZ@1224|Proteobacteria,1RPZ7@1236|Gammaproteobacteria,1WX60@135613|Chromatiales	135613|Chromatiales	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	-	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,ResIII
HKD2_k127_6400159_9	1049564.TevJSym_am00560	1.516e-48	182.0	COG1595@1|root,COG1595@2|Bacteria,1R9WC@1224|Proteobacteria,1SA30@1236|Gammaproteobacteria,1J6NG@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	K	COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog	rpoE1	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD2_k127_6400159_14	1042377.AFPJ01000037_gene2972	9.259e-05	53.0	2EI41@1|root,33BVF@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6400159_11	1442599.JAAN01000033_gene1604	8.431e-11	72.0	2DNXA@1|root,32ZMW@2|Bacteria,1NBF6@1224|Proteobacteria,1SDGN@1236|Gammaproteobacteria,1X7TE@135614|Xanthomonadales	135614|Xanthomonadales	S	Protein of unknown function (DUF3106)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3106
HKD2_k127_6400159_1	1000565.METUNv1_04010	5.813e-243	771.0	COG1282@1|root,COG1282@2|Bacteria,1MUP4@1224|Proteobacteria,2VIDR@28216|Betaproteobacteria,2KURP@206389|Rhodocyclales	206389|Rhodocyclales	C	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane	-	-	1.6.1.2	ko:K00325	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	PNTB
HKD2_k127_6400159_4	864051.BurJ1DRAFT_0810	6.326e-204	640.0	COG3288@1|root,COG3288@2|Bacteria,1MVXU@1224|Proteobacteria,2VJZN@28216|Betaproteobacteria,1KJ4C@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Alanine dehydrogenase/PNT, N-terminal domain	pntA	-	1.6.1.2	ko:K00324	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N,PNTB_4TM
HKD2_k127_6413690_0	84531.JMTZ01000046_gene1045	5.731e-152	501.0	COG4773@1|root,COG4773@2|Bacteria,1NZCG@1224|Proteobacteria,1T1NA@1236|Gammaproteobacteria,1X3J2@135614|Xanthomonadales	135614|Xanthomonadales	P	receptor	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	TonB_dep_Rec
HKD2_k127_6413690_4	1191523.MROS_1827	4.806e-29	126.0	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	-	-	2.3.1.82	ko:K18815	-	-	-	-	br01600,ko00000,ko01000,ko01504	-	-	-	Acetyltransf_1,Acetyltransf_10,Acetyltransf_7
HKD2_k127_6413690_6	1396418.BATQ01000024_gene5210	1.058e-15	91.0	COG1231@1|root,COG1231@2|Bacteria,46WN9@74201|Verrucomicrobia,2IWB8@203494|Verrucomicrobiae	203494|Verrucomicrobiae	E	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
HKD2_k127_6413690_5	1191523.MROS_2453	1.358e-24	113.0	COG0727@1|root,COG0727@2|Bacteria	2|Bacteria	S	metal cluster binding	-	-	-	ko:K06940,ko:K18475	-	-	-	-	ko00000,ko01000,ko02035	-	-	-	CxxCxxCC
HKD2_k127_6413690_2	945713.IALB_2306	4.736e-67	244.0	COG1181@1|root,COG1181@2|Bacteria	2|Bacteria	F	Belongs to the D-alanine--D-alanine ligase family	ddlB1	-	6.3.2.4,6.3.5.5	ko:K01921,ko:K01955	ko00240,ko00250,ko00473,ko00550,ko01100,ko01502,map00240,map00250,map00473,map00550,map01100,map01502	M00051	R00256,R00575,R01150,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC00064,RC00141,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000,ko01011	-	-	-	Dala_Dala_lig_C
HKD2_k127_6413690_3	1235457.C404_03595	3.67e-51	198.0	COG2211@1|root,COG2211@2|Bacteria,1NR4C@1224|Proteobacteria,2W1HW@28216|Betaproteobacteria,1K6BU@119060|Burkholderiaceae	28216|Betaproteobacteria	G	MFS_1 like family	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD2_k127_6413690_1	1499967.BAYZ01000028_gene1264	3.629e-121	400.0	COG1181@1|root,COG1181@2|Bacteria,2NRF0@2323|unclassified Bacteria	2|Bacteria	M	ATP-grasp domain	ddlA	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C
HKD2_k127_6420971_34	1449049.JONW01000012_gene207	9.355e-26	106.0	COG4798@1|root,COG4798@2|Bacteria,1NNHX@1224|Proteobacteria,2U5HN@28211|Alphaproteobacteria,2KFKW@204458|Caulobacterales	204458|Caulobacterales	S	Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6420971_2	946483.Cenrod_0414	1.149e-276	877.0	COG0493@1|root,COG1144@1|root,COG0493@2|Bacteria,COG1144@2|Bacteria,1MU2H@1224|Proteobacteria,2VM9R@28216|Betaproteobacteria,4AD4V@80864|Comamonadaceae	28216|Betaproteobacteria	C	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_20,Pyr_redox_2,Pyr_redox_3
HKD2_k127_6420971_9	395495.Lcho_2151	1.086e-168	534.0	COG1013@1|root,COG1013@2|Bacteria,1MUY9@1224|Proteobacteria,2VKQX@28216|Betaproteobacteria,1KJCA@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain	porB	-	1.2.1.58,1.2.7.1	ko:K00170,ko:K18356	ko00010,ko00020,ko00360,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00360,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R02450,R08034	RC00004,RC00250,RC02742,RC02833,RC02860	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4_11,Fer4_6,TPP_enzyme_C
HKD2_k127_6420971_6	522306.CAP2UW1_2511	8.753e-196	623.0	COG0674@1|root,COG0674@2|Bacteria,1MVM0@1224|Proteobacteria,2VJSA@28216|Betaproteobacteria	28216|Betaproteobacteria	C	pyruvate flavodoxin ferredoxin oxidoreductase	porA	-	1.2.7.1	ko:K00169	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
HKD2_k127_6420971_20	864051.BurJ1DRAFT_4544	2.835e-78	271.0	COG1014@1|root,COG1014@2|Bacteria,1N12F@1224|Proteobacteria,2VQ8C@28216|Betaproteobacteria,1KKPN@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Pyruvate ferredoxin/flavodoxin oxidoreductase	porC	-	1.2.1.58,1.2.7.1	ko:K00172,ko:K18357	ko00010,ko00020,ko00360,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00360,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R02450,R08034	RC00004,RC00250,RC02742,RC02833,RC02860	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR
HKD2_k127_6420971_4	1384054.N790_09365	4.872e-203	651.0	COG4805@1|root,COG4805@2|Bacteria,1MUBX@1224|Proteobacteria,1RMT7@1236|Gammaproteobacteria,1X39Z@135614|Xanthomonadales	135614|Xanthomonadales	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
HKD2_k127_6420971_8	1121013.P873_12085	5.812e-184	587.0	COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,1RN05@1236|Gammaproteobacteria,1X5E6@135614|Xanthomonadales	135614|Xanthomonadales	S	Insulinase (Peptidase family M16)	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
HKD2_k127_6420971_11	1121015.N789_05985	7.094e-158	522.0	COG0612@1|root,COG0612@2|Bacteria,1MU6R@1224|Proteobacteria,1RN3E@1236|Gammaproteobacteria,1X8AF@135614|Xanthomonadales	135614|Xanthomonadales	S	Insulinase (Peptidase family M16)	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
HKD2_k127_6420971_29	1200792.AKYF01000020_gene5048	3.533e-44	171.0	COG0702@1|root,COG0702@2|Bacteria,1UZQQ@1239|Firmicutes,4HABB@91061|Bacilli,276C2@186822|Paenibacillaceae	91061|Bacilli	GM	NAD(P)H-binding	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_10
HKD2_k127_6420971_3	316057.RPD_2526	1.268e-233	751.0	COG0457@1|root,COG1413@1|root,COG0457@2|Bacteria,COG1413@2|Bacteria,1MX2U@1224|Proteobacteria,2TVI2@28211|Alphaproteobacteria,3JUS1@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Cytochrome c554 and c-prime	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554,HEAT_2,Paired_CXXCH_1,TPR_16,TPR_19,TPR_2,TPR_8
HKD2_k127_6420971_31	1449049.JONW01000005_gene1173	5.197e-39	154.0	2DNBN@1|root,32WN2@2|Bacteria,1N5BF@1224|Proteobacteria	1224|Proteobacteria	S	Protein of unknown function (DUF3313)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3313
HKD2_k127_6420971_37	518766.Rmar_0335	2.758e-12	75.0	2EH9H@1|root,30IPX@2|Bacteria,4PF9X@976|Bacteroidetes,1FKCD@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6420971_13	398767.Glov_0364	1.01e-123	416.0	COG0668@1|root,COG0668@2|Bacteria,1N66N@1224|Proteobacteria,42MXP@68525|delta/epsilon subdivisions,2WMI1@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	mechanosensitive ion channel	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel
HKD2_k127_6420971_32	247639.MGP2080_02111	3.667e-32	137.0	COG2067@1|root,COG2067@2|Bacteria,1NDQA@1224|Proteobacteria,1TIWZ@1236|Gammaproteobacteria,1JBA2@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	I	K COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6420971_35	944435.AXAJ01000007_gene1734	3.668e-23	108.0	2E5SP@1|root,330H2@2|Bacteria,1NDBY@1224|Proteobacteria,2VXDV@28216|Betaproteobacteria,1K76Z@119060|Burkholderiaceae	28216|Betaproteobacteria	S	YMGG-like Gly-zipper	-	-	-	-	-	-	-	-	-	-	-	-	Gly-zipper_YMGG
HKD2_k127_6420971_16	1217718.ALOU01000007_gene1227	2.387e-112	391.0	COG1752@1|root,COG4775@1|root,COG1752@2|Bacteria,COG4775@2|Bacteria,1MUM9@1224|Proteobacteria,2VJRI@28216|Betaproteobacteria	28216|Betaproteobacteria	M	surface antigen variable number repeat protein	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Bac_surface_Ag,POTRA,Patatin
HKD2_k127_6420971_12	575540.Isop_2614	2.067e-130	425.0	COG0176@1|root,COG0176@2|Bacteria,2IYC8@203682|Planctomycetes	203682|Planctomycetes	H	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway	-	-	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
HKD2_k127_6420971_0	472759.Nhal_0746	0.0	1394.0	COG3957@1|root,COG3957@2|Bacteria,1MVSE@1224|Proteobacteria,1RPSW@1236|Gammaproteobacteria,1WVZE@135613|Chromatiales	135613|Chromatiales	G	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase	-	-	4.1.2.22,4.1.2.9	ko:K01621	ko00030,ko00710,ko01100,ko01120,map00030,map00710,map01100,map01120	-	R00761,R01621	RC00032,RC00226	ko00000,ko00001,ko01000	-	-	-	XFP,XFP_C,XFP_N
HKD2_k127_6420971_25	566466.NOR53_1062	2.089e-51	196.0	28MAS@1|root,318XW@2|Bacteria,1NU47@1224|Proteobacteria,1SM4U@1236|Gammaproteobacteria,1J7Z3@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function, DUF481	-	-	-	-	-	-	-	-	-	-	-	-	DUF481
HKD2_k127_6420971_15	522306.CAP2UW1_1272	2.453e-120	400.0	COG4313@1|root,COG4313@2|Bacteria,1PRCN@1224|Proteobacteria,2VQHT@28216|Betaproteobacteria,1KQK1@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	C	Protein involved in meta-pathway of phenol degradation	-	-	-	-	-	-	-	-	-	-	-	-	Phenol_MetA_deg
HKD2_k127_6420971_21	2340.JV46_10520	6.76e-68	235.0	COG2930@1|root,COG2930@2|Bacteria,1RCYH@1224|Proteobacteria,1S41U@1236|Gammaproteobacteria,1J6CJ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	s cog2930	CT2216	-	-	-	-	-	-	-	-	-	-	-	Ysc84
HKD2_k127_6420971_18	1458275.AZ34_11470	1.3e-93	320.0	COG0025@1|root,COG0025@2|Bacteria,1N07S@1224|Proteobacteria,2VP23@28216|Betaproteobacteria	28216|Betaproteobacteria	P	Sodium/hydrogen exchanger family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
HKD2_k127_6420971_24	1121033.AUCF01000023_gene49	1.704e-52	198.0	COG1773@1|root,COG1773@2|Bacteria,1N813@1224|Proteobacteria,2U0HG@28211|Alphaproteobacteria,2JU66@204441|Rhodospirillales	204441|Rhodospirillales	C	[NiFe]-hydrogenase assembly, chaperone, HybE	-	-	-	-	-	-	-	-	-	-	-	-	NiFe-hyd_HybE,Rubredoxin
HKD2_k127_6420971_23	1304878.AUGD01000002_gene2316	1.012e-52	198.0	COG1773@1|root,COG1773@2|Bacteria,1MV2U@1224|Proteobacteria,2TV0P@28211|Alphaproteobacteria,3JVWM@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	HupH hydrogenase expression protein, C-terminal conserved region	hupH	-	-	ko:K03618	-	-	-	-	ko00000	-	-	-	HupH_C
HKD2_k127_6420971_36	1123257.AUFV01000003_gene951	2.511e-15	80.0	COG0526@1|root,COG0526@2|Bacteria,1RJ41@1224|Proteobacteria,1SF3B@1236|Gammaproteobacteria	1236|Gammaproteobacteria	CO	Hydrogenase-1 expression protein HyaE	-	-	-	-	-	-	-	-	-	-	-	-	HyaE
HKD2_k127_6420971_22	371731.Rsw2DRAFT_2142	3.22e-62	224.0	COG0680@1|root,COG0680@2|Bacteria,1RE1C@1224|Proteobacteria,2U2IN@28211|Alphaproteobacteria,1FAZA@1060|Rhodobacter	28211|Alphaproteobacteria	C	Hydrogenase maturation protease	hupD	GO:0003674,GO:0003824,GO:0004175,GO:0006464,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009987,GO:0010467,GO:0016485,GO:0016787,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0051604,GO:0070011,GO:0071704,GO:0140096,GO:1901564	-	ko:K03605	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	HycI
HKD2_k127_6420971_19	1336235.JAEG01000026_gene2626	2.681e-87	297.0	COG1969@1|root,COG1969@2|Bacteria,1MU87@1224|Proteobacteria,2TSH2@28211|Alphaproteobacteria,4BDI6@82115|Rhizobiaceae	28211|Alphaproteobacteria	C	Prokaryotic cytochrome b561	hupC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03620	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	Ni_hydr_CYTB
HKD2_k127_6420971_1	1134912.AJTV01000015_gene320	6.1e-322	991.0	COG0374@1|root,COG0374@2|Bacteria,1MWFJ@1224|Proteobacteria,2TSH1@28211|Alphaproteobacteria,36X2D@31993|Methylocystaceae	28211|Alphaproteobacteria	C	Nickel-dependent hydrogenase	hupL	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	1.12.99.6	ko:K06281	ko00633,ko01120,map00633,map01120	-	R08034	RC00250	ko00000,ko00001,ko01000	-	-	-	NiFeSe_Hases
HKD2_k127_6420971_7	420662.Mpe_A2827	4.473e-187	603.0	COG1740@1|root,COG1740@2|Bacteria,1MWAC@1224|Proteobacteria,2VK03@28216|Betaproteobacteria,1KJYT@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	TIGRFAM hydrogenase (NiFe) small subunit (hydA)	hoxK	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	1.12.99.6	ko:K06282	ko00633,ko01120,map00633,map01120	-	R08034	RC00250	ko00000,ko00001,ko01000	-	-	-	NiFe_hyd_SSU_C,Oxidored_q6
HKD2_k127_6420971_33	1255043.TVNIR_2063	3.922e-32	132.0	COG0664@1|root,COG0664@2|Bacteria,1RC7W@1224|Proteobacteria,1S2ZD@1236|Gammaproteobacteria,1WY6E@135613|Chromatiales	135613|Chromatiales	T	PFAM Cyclic nucleotide-binding	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
HKD2_k127_6420971_5	631362.Thi970DRAFT_03026	1.102e-198	629.0	COG0702@1|root,COG0702@2|Bacteria,1MW54@1224|Proteobacteria,1RNS7@1236|Gammaproteobacteria,1WXFK@135613|Chromatiales	135613|Chromatiales	GM	nucleoside-diphosphate sugar epimerase	-	-	-	-	-	-	-	-	-	-	-	-	DUF2867,NAD_binding_10
HKD2_k127_6420971_27	338969.Rfer_0637	3.909e-47	183.0	COG2905@1|root,COG2905@2|Bacteria,1N7MU@1224|Proteobacteria,2VVGU@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
HKD2_k127_6420971_17	375286.mma_2426	7.292e-96	328.0	COG4775@1|root,COG4775@2|Bacteria,1QVN6@1224|Proteobacteria,2VNCE@28216|Betaproteobacteria	28216|Betaproteobacteria	M	Surface antigen	-	-	-	-	-	-	-	-	-	-	-	-	Bac_surface_Ag
HKD2_k127_6420971_26	1245471.PCA10_07040	1.096e-48	196.0	COG1814@1|root,COG1814@2|Bacteria,1R469@1224|Proteobacteria,1TCA7@1236|Gammaproteobacteria,1YK48@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6420971_28	1217718.ALOU01000042_gene227	2.332e-46	178.0	2E3FB@1|root,32YE4@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6420971_30	1231391.AMZF01000042_gene813	4.559e-40	164.0	COG3203@1|root,COG3203@2|Bacteria,1MWUN@1224|Proteobacteria,2VT6T@28216|Betaproteobacteria,3T8SN@506|Alcaligenaceae	28216|Betaproteobacteria	M	Gram-negative porin	-	-	-	-	-	-	-	-	-	-	-	-	Porin_4
HKD2_k127_6420971_10	1366050.N234_23725	1.169e-160	527.0	COG0707@1|root,COG0707@2|Bacteria,1R660@1224|Proteobacteria,2VPVW@28216|Betaproteobacteria,1KCYM@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6420971_14	497964.CfE428DRAFT_0248	4.295e-122	397.0	COG0387@1|root,COG0387@2|Bacteria,46UPT@74201|Verrucomicrobia	74201|Verrucomicrobia	P	Sodium/calcium exchanger protein	-	-	-	-	-	-	-	-	-	-	-	-	Na_Ca_ex
HKD2_k127_6451084_8	1123368.AUIS01000023_gene933	2.063e-89	322.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,2NDJD@225057|Acidithiobacillales	225057|Acidithiobacillales	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	CZB,EAL,GGDEF,PAS,PAS_4
HKD2_k127_6451084_10	247634.GPB2148_718	4.154e-66	241.0	COG4942@1|root,COG4942@2|Bacteria,1MY3E@1224|Proteobacteria,1RPQP@1236|Gammaproteobacteria,1J4S5@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	D	COG4942 Membrane-bound metallopeptidase	envC	GO:0000920,GO:0001896,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008219,GO:0009273,GO:0009314,GO:0009628,GO:0009987,GO:0012501,GO:0016020,GO:0016787,GO:0030288,GO:0030313,GO:0031975,GO:0032153,GO:0042221,GO:0042493,GO:0042546,GO:0042597,GO:0043085,GO:0044085,GO:0044093,GO:0044464,GO:0050790,GO:0050896,GO:0051301,GO:0051336,GO:0051345,GO:0065007,GO:0065009,GO:0071554,GO:0071840,GO:0071944	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
HKD2_k127_6451084_17	1123517.JOMR01000001_gene394	2.869e-24	108.0	COG0607@1|root,COG0607@2|Bacteria,1MZ83@1224|Proteobacteria,1S8ZI@1236|Gammaproteobacteria,4614X@72273|Thiotrichales	72273|Thiotrichales	P	PFAM Rhodanese-like	-	-	2.8.1.1,2.8.1.2	ko:K01011	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko01000	-	-	-	Rhodanese
HKD2_k127_6451084_16	666685.R2APBS1_2607	1.47e-27	121.0	COG0695@1|root,COG0695@2|Bacteria,1N72P@1224|Proteobacteria,1SCA2@1236|Gammaproteobacteria,1X7E1@135614|Xanthomonadales	135614|Xanthomonadales	O	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins	grxC	-	-	ko:K03676	-	-	-	-	ko00000,ko03110	-	-	-	Glutaredoxin
HKD2_k127_6451084_15	1123253.AUBD01000004_gene1109	3.485e-29	123.0	COG1952@1|root,COG1952@2|Bacteria,1RI75@1224|Proteobacteria,1S62H@1236|Gammaproteobacteria,1X65X@135614|Xanthomonadales	135614|Xanthomonadales	U	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA	secB	-	-	ko:K03071	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03110	3.A.5	-	-	SecB
HKD2_k127_6451084_6	1033802.SSPSH_002498	7.065e-108	364.0	COG0240@1|root,COG0240@2|Bacteria,1MUU3@1224|Proteobacteria,1RPQ7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	Glycerol-3-phosphate dehydrogenase	gpsA	GO:0003674,GO:0003824,GO:0004367,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006072,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0045017,GO:0046474,GO:0046486,GO:0047952,GO:0052646,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901576	1.1.1.94	ko:K00057	ko00564,ko01110,map00564,map01110	-	R00842,R00844	RC00029	ko00000,ko00001,ko01000	-	-	iJN746.PP_4169,iSFV_1184.SFV_3923	NAD_Gly3P_dh_C,NAD_Gly3P_dh_N
HKD2_k127_6451084_11	1112217.PPL19_14824	6.275e-59	211.0	COG0219@1|root,COG0219@2|Bacteria,1RCY4@1224|Proteobacteria,1S3PI@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide	trmL	GO:0001510,GO:0002128,GO:0002130,GO:0002131,GO:0002132,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016300,GO:0016427,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0052665,GO:0052666,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.1.1.207	ko:K03216	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	SpoU_methylase
HKD2_k127_6451084_13	713587.THITH_07545	4.072e-42	158.0	COG0517@1|root,COG0517@2|Bacteria,1N0H3@1224|Proteobacteria,1S6HB@1236|Gammaproteobacteria,1X24R@135613|Chromatiales	135613|Chromatiales	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
HKD2_k127_6451084_4	1279019.ARQK01000022_gene162	2.614e-150	481.0	COG0167@1|root,COG0167@2|Bacteria,1MU7C@1224|Proteobacteria,1T02D@1236|Gammaproteobacteria,1WW5T@135613|Chromatiales	135613|Chromatiales	F	Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily	pyrD	-	1.3.1.14	ko:K17828	ko00240,ko01100,map00240,map01100	M00051	R01869	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
HKD2_k127_6451084_3	349124.Hhal_1215	2.209e-185	591.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1WW4B@135613|Chromatiales	135613|Chromatiales	T	response regulator	glnG	-	-	ko:K07712	ko02020,map02020	M00497	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD2_k127_6451084_7	713586.KB900536_gene2055	2.662e-98	333.0	COG3852@1|root,COG3852@2|Bacteria,1MVN6@1224|Proteobacteria,1RN15@1236|Gammaproteobacteria,1WWFQ@135613|Chromatiales	135613|Chromatiales	T	signal transduction histidine kinase	-	-	2.7.13.3	ko:K07708	ko02020,map02020	M00497	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS,PAS_4
HKD2_k127_6451084_19	1121878.AUGL01000011_gene810	8.477e-09	64.0	2E42P@1|root,32YZ5@2|Bacteria,1N868@1224|Proteobacteria,1SCUM@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	penicillin-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	BiPBP_C,DUF4124
HKD2_k127_6451084_1	243233.MCA1677	1.225e-245	764.0	COG0174@1|root,COG0174@2|Bacteria,1MUGQ@1224|Proteobacteria,1RMD1@1236|Gammaproteobacteria,1XEEH@135618|Methylococcales	135618|Methylococcales	F	TIGRFAM glutamine synthetase, type I	-	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
HKD2_k127_6451084_14	1089551.KE386572_gene391	2.426e-41	172.0	COG3115@1|root,COG3115@2|Bacteria,1QVM5@1224|Proteobacteria,2TWI6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	D	Protein of unknown function (DUF3300)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3300
HKD2_k127_6451084_9	1267534.KB906754_gene3425	2.897e-78	272.0	COG4786@1|root,COG4786@2|Bacteria	2|Bacteria	N	Flagellar basal body rod	flgK	-	-	ko:K02396	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	DUF2950,Flg_bb_rod,Flg_bbr_C
HKD2_k127_6451084_0	511062.GU3_15895	4.752e-266	839.0	COG0028@1|root,COG0028@2|Bacteria,1MWUB@1224|Proteobacteria,1S0VC@1236|Gammaproteobacteria	1236|Gammaproteobacteria	EH	Belongs to the TPP enzyme family	xsc	-	2.3.3.15	ko:K03852	ko00430,map00430	-	R05651	RC02903,RC02909	ko00000,ko00001,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
HKD2_k127_6451084_2	652103.Rpdx1_2790	2.735e-242	761.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2TR2W@28211|Alphaproteobacteria,3JQTA@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	IQ	AMP-binding enzyme C-terminal domain	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
HKD2_k127_6451084_5	1380367.JIBC01000007_gene940	4.775e-129	420.0	COG2130@1|root,COG2130@2|Bacteria,1MUC2@1224|Proteobacteria,2TQYM@28211|Alphaproteobacteria,3ZVAE@60136|Sulfitobacter	28211|Alphaproteobacteria	S	N-terminal domain of oxidoreductase	MA20_40260	-	-	ko:K07119	-	-	-	-	ko00000	-	-	-	ADH_N_2,ADH_zinc_N
HKD2_k127_6451084_18	1123487.KB892857_gene2378	2.53e-13	72.0	2E49J@1|root,32Z5A@2|Bacteria,1NFEB@1224|Proteobacteria,2VX10@28216|Betaproteobacteria,2KZEE@206389|Rhodocyclales	206389|Rhodocyclales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6451084_12	270374.MELB17_00940	1.301e-52	188.0	COG1714@1|root,COG1714@2|Bacteria,1MZAD@1224|Proteobacteria,1S6E9@1236|Gammaproteobacteria,468IV@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	membrane protein domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4339,RDD
HKD2_k127_6457269_0	1380394.JADL01000004_gene5966	1.409e-297	921.0	COG0529@1|root,COG2895@1|root,COG0529@2|Bacteria,COG2895@2|Bacteria,1MUD9@1224|Proteobacteria,2TQNJ@28211|Alphaproteobacteria,2JPGB@204441|Rhodospirillales	204441|Rhodospirillales	P	Catalyzes the synthesis of activated sulfate	cysC	-	2.7.1.25,2.7.7.4	ko:K00955	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176	R00509,R00529,R04928,R04929	RC00002,RC00078,RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	APS_kinase,GTP_EFTU,GTP_EFTU_D2
HKD2_k127_6472080_4	1442599.JAAN01000024_gene1854	2.752e-131	429.0	COG0015@1|root,COG0015@2|Bacteria,1MV4B@1224|Proteobacteria,1RN93@1236|Gammaproteobacteria,1X3E0@135614|Xanthomonadales	135614|Xanthomonadales	F	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily	purB	-	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	-	ASL_C,Lyase_1
HKD2_k127_6472080_5	1163617.SCD_n00786	5.304e-81	274.0	COG0625@1|root,COG0625@2|Bacteria,1RHSK@1224|Proteobacteria,2VIJ5@28216|Betaproteobacteria	28216|Betaproteobacteria	O	Glutathione S-transferase	yibF	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C,GST_C_2,GST_N_3
HKD2_k127_6472080_11	582515.KR51_00029770	1.959e-48	180.0	COG3187@1|root,COG3187@2|Bacteria	2|Bacteria	O	response to heat	-	-	-	-	-	-	-	-	-	-	-	-	META
HKD2_k127_6472080_12	522306.CAP2UW1_2189	6.52e-46	181.0	2E3TX@1|root,32YRB@2|Bacteria,1NAJY@1224|Proteobacteria,2VX3D@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6472080_19	926566.Terro_4202	2.098e-19	89.0	COG2261@1|root,COG2261@2|Bacteria	2|Bacteria	S	Transglycosylase associated protein	MA20_40075	-	-	-	-	-	-	-	-	-	-	-	Transgly_assoc
HKD2_k127_6472080_7	189753.AXAS01000041_gene2534	1.613e-67	245.0	COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,2TSG1@28211|Alphaproteobacteria,3JSYZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
HKD2_k127_6472080_8	330084.JNYZ01000033_gene5642	1.221e-58	216.0	COG0667@1|root,COG0667@2|Bacteria,2GMNA@201174|Actinobacteria,4DZDK@85010|Pseudonocardiales	201174|Actinobacteria	C	Aldo/keto reductase family	yajO	-	1.1.1.91	ko:K05882	-	-	-	-	ko00000,ko01000	-	-	-	Aldo_ket_red
HKD2_k127_6472080_20	159087.Daro_1874	5.419e-15	83.0	COG3427@1|root,COG3427@2|Bacteria,1N55Y@1224|Proteobacteria,2VTZD@28216|Betaproteobacteria,2KX5B@206389|Rhodocyclales	206389|Rhodocyclales	S	Polyketide cyclase / dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc
HKD2_k127_6472080_24	1244531.CIG1485E_0530	0.0002722	51.0	COG0454@1|root,COG0456@2|Bacteria,1NKKQ@1224|Proteobacteria,42S0Q@68525|delta/epsilon subdivisions,2YP87@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	K	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HKD2_k127_6472080_18	1227349.C170_17147	7.486e-25	114.0	COG5522@1|root,COG5522@2|Bacteria,1V4XE@1239|Firmicutes,4HHC6@91061|Bacilli,26SXX@186822|Paenibacillaceae	91061|Bacilli	S	integral membrane protein	ywaF	-	-	-	-	-	-	-	-	-	-	-	Intg_mem_TP0381
HKD2_k127_6472080_13	236097.ADG881_3136	1.281e-39	160.0	COG3239@1|root,COG3239@2|Bacteria,1R8GH@1224|Proteobacteria,1S66B@1236|Gammaproteobacteria,1XKMK@135619|Oceanospirillales	135619|Oceanospirillales	I	fatty acid desaturase	-	-	-	-	-	-	-	-	-	-	-	-	FA_desaturase
HKD2_k127_6472080_14	1397527.Q670_01560	8.524e-39	157.0	COG3239@1|root,COG3239@2|Bacteria,1R8GH@1224|Proteobacteria,1S66B@1236|Gammaproteobacteria,1XKMK@135619|Oceanospirillales	135619|Oceanospirillales	I	fatty acid desaturase	-	-	-	-	-	-	-	-	-	-	-	-	FA_desaturase
HKD2_k127_6472080_22	29581.BW37_01667	2.687e-08	58.0	COG3655@1|root,COG3655@2|Bacteria,1RBPK@1224|Proteobacteria,2VIYU@28216|Betaproteobacteria,475EJ@75682|Oxalobacteraceae	28216|Betaproteobacteria	K	Cro/C1-type HTH DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_26
HKD2_k127_6472080_10	1499967.BAYZ01000123_gene2546	6.045e-49	186.0	COG3675@1|root,COG3675@2|Bacteria	2|Bacteria	I	Lipase (class 3)	-	-	3.1.1.3	ko:K01046	ko00561,ko01100,map00561,map01100	M00098	R02250,R02687	RC00020,RC00037,RC00041,RC00094	ko00000,ko00001,ko00002,ko01000	-	-	-	Lipase_3
HKD2_k127_6472080_2	716928.AJQT01000066_gene3801	1.45e-215	704.0	COG0457@1|root,COG2114@1|root,COG3899@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2TQVN@28211|Alphaproteobacteria,4B81Q@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	Adenylate	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,DZR,Guanylate_cyc,SAM_1
HKD2_k127_6472080_15	1240349.ANGC01000066_gene79	1.187e-35	152.0	COG2124@1|root,COG2124@2|Bacteria,2I9EA@201174|Actinobacteria,4FUGN@85025|Nocardiaceae	201174|Actinobacteria	Q	Cytochrome P450	-	-	-	-	-	-	-	-	-	-	-	-	p450
HKD2_k127_6472080_16	864051.BurJ1DRAFT_3758	1.377e-33	138.0	COG3945@1|root,COG3945@2|Bacteria,1PPUF@1224|Proteobacteria,2VVJ9@28216|Betaproteobacteria,1KNS8@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	PFAM Hemerythrin HHE cation binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
HKD2_k127_6472080_23	1206777.B195_18021	2.492e-06	57.0	COG0583@1|root,COG0583@2|Bacteria,1Q8UG@1224|Proteobacteria,1S05A@1236|Gammaproteobacteria,1ZAMB@136849|Pseudomonas syringae group	1236|Gammaproteobacteria	K	Bacterial regulatory helix-turn-helix protein, lysR family	hcaR	GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2001141	-	ko:K05817	-	-	-	-	ko00000,ko03000	-	-	-	HTH_1,LysR_substrate
HKD2_k127_6472080_9	1458275.AZ34_13815	3.899e-55	201.0	COG3476@1|root,COG3476@2|Bacteria,1MZC1@1224|Proteobacteria,2VTIJ@28216|Betaproteobacteria,4AFM3@80864|Comamonadaceae	28216|Betaproteobacteria	T	TspO/MBR family	-	-	-	ko:K05770	ko04080,ko04214,ko04979,ko05166,map04080,map04214,map04979,map05166	-	-	-	ko00000,ko00001,ko02000	9.A.24	-	-	TspO_MBR
HKD2_k127_6472080_3	365046.Rta_00130	8.458e-178	572.0	COG4948@1|root,COG4948@2|Bacteria,1MYZE@1224|Proteobacteria,2VJX2@28216|Betaproteobacteria,4ADRU@80864|Comamonadaceae	28216|Betaproteobacteria	M	Mandelate racemase / muconate lactonizing enzyme, C-terminal domain	mdlA	-	5.1.2.2	ko:K01781	ko00627,ko01120,map00627,map01120	-	R03791,R04161	RC00998	ko00000,ko00001,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
HKD2_k127_6472080_17	1458275.AZ34_12305	7.423e-32	133.0	COG4147@1|root,COG4147@2|Bacteria,1MVJ8@1224|Proteobacteria,2VH3P@28216|Betaproteobacteria,4AA9Z@80864|Comamonadaceae	28216|Betaproteobacteria	S	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	actP_1	-	-	ko:K14393	-	-	-	-	ko00000,ko02000	2.A.21.7	-	-	SSF
HKD2_k127_6472080_0	1163617.SCD_n01957	0.0	1071.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2VIP3@28216|Betaproteobacteria	28216|Betaproteobacteria	I	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	acsA	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
HKD2_k127_6472080_6	864051.BurJ1DRAFT_2793	7.483e-75	260.0	COG2862@1|root,COG2862@2|Bacteria,1RANN@1224|Proteobacteria,2VK3P@28216|Betaproteobacteria,1KK23@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	UPF0114 protein	-	-	-	-	-	-	-	-	-	-	-	-	UPF0114
HKD2_k127_6472080_1	1235457.C404_12315	2.872e-273	848.0	COG1838@1|root,COG1951@1|root,COG1838@2|Bacteria,COG1951@2|Bacteria,1MUV9@1224|Proteobacteria,2VIP7@28216|Betaproteobacteria,1K289@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Catalyzes the reversible hydration of fumarate to (S)- malate	fumA	-	4.2.1.2	ko:K01676	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumerase,Fumerase_C
HKD2_k127_6496267_25	266264.Rmet_2568	2.52e-130	444.0	COG0207@1|root,COG0207@2|Bacteria,1MUBD@1224|Proteobacteria,2VIIR@28216|Betaproteobacteria,1K0Y1@119060|Burkholderiaceae	28216|Betaproteobacteria	F	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis	thyA	-	2.1.1.45	ko:K00560	ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523	M00053	R02101	RC00219,RC00332	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylat_synt
HKD2_k127_6496267_34	472759.Nhal_3905	1.584e-109	359.0	COG0682@1|root,COG0682@2|Bacteria,1MVE3@1224|Proteobacteria,1RMVK@1236|Gammaproteobacteria,1WW3W@135613|Chromatiales	135613|Chromatiales	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	lgt	-	-	ko:K13292	-	-	-	-	ko00000,ko01000	-	-	-	LGT
HKD2_k127_6496267_20	477228.YO5_19347	6.186e-140	456.0	COG1092@1|root,COG1092@2|Bacteria,1MUGB@1224|Proteobacteria,1RN7Z@1236|Gammaproteobacteria,1Z0VQ@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	J	(SAM)-dependent	rlmI	-	2.1.1.191	ko:K06969	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_SAM
HKD2_k127_6496267_3	396588.Tgr7_2744	2.654e-244	773.0	COG1331@1|root,COG1331@2|Bacteria,1MUUT@1224|Proteobacteria,1RSQQ@1236|Gammaproteobacteria,1WWA4@135613|Chromatiales	135613|Chromatiales	O	Protein of unknown function, DUF255	-	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	Thioredox_DsbH
HKD2_k127_6496267_73	794903.OPIT5_21125	6.404e-43	166.0	COG0537@1|root,COG0537@2|Bacteria	2|Bacteria	FG	bis(5'-adenosyl)-triphosphatase activity	-	-	-	-	-	-	-	-	-	-	-	-	HIT
HKD2_k127_6496267_67	653733.Selin_0993	6.038e-50	183.0	COG3169@1|root,COG3169@2|Bacteria	2|Bacteria	S	Protein conserved in bacteria	-	-	-	ko:K09922	-	-	-	-	ko00000	-	-	-	DMT_6
HKD2_k127_6496267_83	1121918.ARWE01000001_gene2356	1.379e-29	129.0	COG1011@1|root,COG1011@2|Bacteria,1Q2A2@1224|Proteobacteria,42WDV@68525|delta/epsilon subdivisions,2WRQS@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Haloacid dehalogenase-like hydrolase	-	-	3.1.3.10	ko:K07025,ko:K20866	ko00010,ko01120,map00010,map01120	-	R00947	RC00078	ko00000,ko00001,ko01000	-	-	-	HAD_2
HKD2_k127_6496267_15	522306.CAP2UW1_0553	5.093e-172	549.0	COG1055@1|root,COG1055@2|Bacteria,1PUZK@1224|Proteobacteria,2VKEF@28216|Betaproteobacteria	28216|Betaproteobacteria	P	Involved in arsenical resistance. Thought to form the channel of an arsenite pump	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6496267_64	690850.Desaf_1632	3.594e-55	201.0	COG2045@1|root,COG2045@2|Bacteria,1N3KG@1224|Proteobacteria,431UT@68525|delta/epsilon subdivisions,2WWVQ@28221|Deltaproteobacteria,2MAMW@213115|Desulfovibrionales	28221|Deltaproteobacteria	H	Belongs to the ComB family	-	-	3.1.3.71	ko:K05979	ko00680,ko01120,map00680,map01120	M00358	R05789	RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	2-ph_phosp
HKD2_k127_6496267_24	1348635.BBJY01000014_gene789	1.661e-131	429.0	COG0019@1|root,COG0019@2|Bacteria,1MZ7Y@1224|Proteobacteria,1RQJ4@1236|Gammaproteobacteria,1XVHW@135623|Vibrionales	135623|Vibrionales	E	Pyridoxal-dependent decarboxylase, pyridoxal binding domain	-	-	4.1.1.17	ko:K01581	ko00330,ko00480,ko01100,ko01110,ko01130,map00330,map00480,map01100,map01110,map01130	M00134	R00670	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
HKD2_k127_6496267_38	1128421.JAGA01000002_gene1530	3.15e-96	326.0	COG0009@1|root,COG0009@2|Bacteria,2NPMH@2323|unclassified Bacteria	2|Bacteria	J	Belongs to the SUA5 family	sua5	GO:0000049,GO:0000166,GO:0002949,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006450,GO:0006725,GO:0006807,GO:0008033,GO:0008144,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034470,GO:0034641,GO:0034660,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0065007,GO:0065008,GO:0070525,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363	2.7.7.87	ko:K07566	-	-	R10463	RC00745	ko00000,ko01000,ko03009,ko03016	-	-	-	SUA5,Sua5_yciO_yrdC
HKD2_k127_6496267_48	1479238.JQMZ01000001_gene60	5.641e-78	279.0	COG1629@1|root,COG4771@2|Bacteria,1R533@1224|Proteobacteria,2TVP0@28211|Alphaproteobacteria,43Z9M@69657|Hyphomonadaceae	28211|Alphaproteobacteria	P	TonB dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
HKD2_k127_6496267_41	1479238.JQMZ01000001_gene60	1.806e-92	323.0	COG1629@1|root,COG4771@2|Bacteria,1R533@1224|Proteobacteria,2TVP0@28211|Alphaproteobacteria,43Z9M@69657|Hyphomonadaceae	28211|Alphaproteobacteria	P	TonB dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
HKD2_k127_6496267_4	36331.EPrPI00000014948	3.881e-244	784.0	COG0265@1|root,KOG1421@2759|Eukaryota,1MAFU@121069|Pythiales	121069|Pythiales	O	Pro-apoptotic serine protease	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_1,PDZ_2,Trypsin_2
HKD2_k127_6496267_29	1026882.MAMP_03142	6.902e-120	397.0	COG0524@1|root,COG0524@2|Bacteria,1QTMS@1224|Proteobacteria,1RQQY@1236|Gammaproteobacteria,460BF@72273|Thiotrichales	72273|Thiotrichales	G	PFAM pfkB family carbohydrate kinase	-	-	2.7.1.20	ko:K00856	ko00230,ko01100,map00230,map01100	-	R00185	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
HKD2_k127_6496267_2	1123256.KB907926_gene944	5.218e-246	766.0	COG1003@1|root,COG1003@2|Bacteria,1MUDP@1224|Proteobacteria,1RND3@1236|Gammaproteobacteria,1X35C@135614|Xanthomonadales	135614|Xanthomonadales	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvP	-	1.4.4.2	ko:K00281,ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko00002,ko01000	-	-	-	GDC-P
HKD2_k127_6496267_8	1122603.ATVI01000005_gene3676	1.214e-199	631.0	COG0403@1|root,COG0403@2|Bacteria,1MVC1@1224|Proteobacteria,1RPGZ@1236|Gammaproteobacteria,1X3XE@135614|Xanthomonadales	135614|Xanthomonadales	E	Glycine cleavage system P-protein	-	-	1.4.4.2	ko:K00282	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	-	GDC-P
HKD2_k127_6496267_71	1395516.PMO01_26225	6.476e-46	175.0	COG0509@1|root,COG0509@2|Bacteria,1RGV7@1224|Proteobacteria,1S656@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	gcvH	GO:0001505,GO:0003674,GO:0005488,GO:0005504,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006544,GO:0006546,GO:0006807,GO:0008150,GO:0008152,GO:0008289,GO:0009056,GO:0009063,GO:0009069,GO:0009071,GO:0009987,GO:0016054,GO:0017144,GO:0019464,GO:0019752,GO:0031405,GO:0031406,GO:0033293,GO:0036094,GO:0042133,GO:0042135,GO:0042737,GO:0043167,GO:0043168,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0048037,GO:0050662,GO:0065007,GO:0065008,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1901681	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	iE2348C_1286.E2348C_3156,iPC815.YPO0906	GCV_H
HKD2_k127_6496267_18	396588.Tgr7_2759	1.969e-150	486.0	COG0404@1|root,COG0404@2|Bacteria,1MV96@1224|Proteobacteria,1RN2A@1236|Gammaproteobacteria,1WWZ0@135613|Chromatiales	135613|Chromatiales	E	The glycine cleavage system catalyzes the degradation of glycine	gcvT	-	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	GCV_T,GCV_T_C
HKD2_k127_6496267_9	472759.Nhal_1913	3.088e-199	642.0	COG4805@1|root,COG4805@2|Bacteria,1MUBX@1224|Proteobacteria,1RMT7@1236|Gammaproteobacteria,1X04H@135613|Chromatiales	135613|Chromatiales	S	Bacterial protein of unknown function (DUF885)	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
HKD2_k127_6496267_10	522306.CAP2UW1_2111	4.883e-196	625.0	COG0821@1|root,COG0821@2|Bacteria,1MUAX@1224|Proteobacteria,2VID7@28216|Betaproteobacteria,1KQGI@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	I	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate	ispG	-	1.17.7.1,1.17.7.3	ko:K03526	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R08689,R10859	RC01486	ko00000,ko00001,ko00002,ko01000	-	-	-	GcpE
HKD2_k127_6496267_77	1415780.JPOG01000001_gene1595	9.664e-39	150.0	COG2154@1|root,COG2154@2|Bacteria,1RH99@1224|Proteobacteria,1SAUS@1236|Gammaproteobacteria,1X738@135614|Xanthomonadales	135614|Xanthomonadales	H	pterin-4-alpha-carbinolamine dehydratase	phhB	-	4.2.1.96	ko:K01724	ko00790,map00790	-	R04734	RC01208	ko00000,ko00001,ko01000,ko04147	-	-	-	Pterin_4a
HKD2_k127_6496267_53	187272.Mlg_2413	9.441e-66	235.0	COG5473@1|root,COG5473@2|Bacteria,1MVRU@1224|Proteobacteria,1RPJA@1236|Gammaproteobacteria,1WWXR@135613|Chromatiales	135613|Chromatiales	S	Predicted integral membrane protein (DUF2189)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2189
HKD2_k127_6496267_11	1128421.JAGA01000002_gene660	1.24e-194	627.0	COG1960@1|root,COG1960@2|Bacteria	2|Bacteria	I	acyl-CoA dehydrogenase activity	-	-	-	ko:K09456	-	-	-	-	ko00000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M
HKD2_k127_6496267_37	1249627.D779_0332	1.407e-96	333.0	COG0654@1|root,COG0654@2|Bacteria,1MU6I@1224|Proteobacteria,1RND5@1236|Gammaproteobacteria,1WVWX@135613|Chromatiales	135613|Chromatiales	CH	TIGRFAM Ubiquinone biosynthesis hydroxylase, UbiH UbiF VisC COQ6	-	-	-	ko:K18800	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04987,R08768	RC00046	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_3
HKD2_k127_6496267_30	713586.KB900536_gene2597	3.324e-116	388.0	COG0654@1|root,COG0654@2|Bacteria,1MU6I@1224|Proteobacteria,1RMS3@1236|Gammaproteobacteria,1WW09@135613|Chromatiales	135613|Chromatiales	CH	Ubiquinone biosynthesis hydroxylase, UbiH UbiF VisC COQ6	-	-	-	ko:K03185	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04989,R08773	RC02670	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_3
HKD2_k127_6496267_14	396588.Tgr7_2764	3.543e-188	596.0	COG0006@1|root,COG0006@2|Bacteria,1MUZS@1224|Proteobacteria,1RN0W@1236|Gammaproteobacteria,1WWJH@135613|Chromatiales	135613|Chromatiales	E	peptidase M24B, X-Pro dipeptidase aminopeptidase	-	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	AMP_N,Peptidase_M24
HKD2_k127_6496267_85	713586.KB900536_gene2595	1.839e-25	118.0	COG3079@1|root,COG3079@2|Bacteria,1N7W0@1224|Proteobacteria,1SCPW@1236|Gammaproteobacteria,1WYR7@135613|Chromatiales	135613|Chromatiales	S	Belongs to the UPF0149 family	-	-	-	ko:K09895	-	-	-	-	ko00000	-	-	-	UPF0149
HKD2_k127_6496267_90	472759.Nhal_3714	2.317e-10	70.0	2C0ET@1|root,33A9M@2|Bacteria,1NGE5@1224|Proteobacteria,1SX58@1236|Gammaproteobacteria,1WZBH@135613|Chromatiales	135613|Chromatiales	S	TIGRFAM TIGR02449 family protein	-	-	-	ko:K09892	-	-	-	-	ko00000,ko03036	-	-	-	-
HKD2_k127_6496267_86	713586.KB900536_gene2593	9.3e-23	105.0	COG3027@1|root,COG3027@2|Bacteria,1N6YN@1224|Proteobacteria,1SCBI@1236|Gammaproteobacteria,1WZF3@135613|Chromatiales	135613|Chromatiales	D	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division	-	-	-	ko:K09888	-	-	-	-	ko00000,ko03036	-	-	-	ZapA
HKD2_k127_6496267_82	1123279.ATUS01000001_gene2080	5.842e-30	127.0	COG0212@1|root,COG0212@2|Bacteria,1MZG0@1224|Proteobacteria,1S612@1236|Gammaproteobacteria,1J6KP@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	H	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family	ygfA	GO:0003674,GO:0003824,GO:0006082,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016882,GO:0018130,GO:0019438,GO:0019752,GO:0022611,GO:0030272,GO:0032502,GO:0034641,GO:0035999,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0046653,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.3.2	ko:K01934	ko00670,ko01100,map00670,map01100	-	R02301	RC00183	ko00000,ko00001,ko01000	-	-	iECABU_c1320.ECABU_c31940,iECOK1_1307.ECOK1_3298,iECSF_1327.ECSF_2705,iUTI89_1310.UTI89_C3298	5-FTHF_cyc-lig
HKD2_k127_6496267_63	118005.AWNK01000011_gene100	1.505e-55	198.0	COG2947@1|root,COG2947@2|Bacteria	2|Bacteria	L	Ubiquinol--cytochrome c reductase	MA20_25125	-	-	-	-	-	-	-	-	-	-	-	EVE
HKD2_k127_6496267_43	765911.Thivi_4240	8.417e-92	307.0	COG0120@1|root,COG0120@2|Bacteria,1MVGR@1224|Proteobacteria,1RNF8@1236|Gammaproteobacteria,1WVVE@135613|Chromatiales	135613|Chromatiales	G	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate	rpiA	-	5.3.1.6	ko:K01807	ko00030,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167,M00580	R01056	RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	Rib_5-P_isom_A
HKD2_k127_6496267_7	1123368.AUIS01000005_gene485	1.723e-201	637.0	COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,1RQX2@1236|Gammaproteobacteria,2NBSD@225057|Acidithiobacillales	225057|Acidithiobacillales	C	FAD linked oxidases, C-terminal domain	-	-	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
HKD2_k127_6496267_35	1123368.AUIS01000005_gene484	5.39e-107	359.0	COG0277@1|root,COG0277@2|Bacteria,1MVYV@1224|Proteobacteria,1RN4G@1236|Gammaproteobacteria,2NC9T@225057|Acidithiobacillales	225057|Acidithiobacillales	C	FAD binding domain	glcE	-	-	ko:K11472	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	FAD-oxidase_C,FAD_binding_4
HKD2_k127_6496267_21	1123368.AUIS01000005_gene483	2.675e-139	454.0	COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,1RPAB@1236|Gammaproteobacteria,2NBWP@225057|Acidithiobacillales	225057|Acidithiobacillales	C	4Fe-4S dicluster domain	glcF	-	-	ko:K11473	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	CCG,Fer4_7
HKD2_k127_6496267_32	666685.R2APBS1_0246	1.487e-113	372.0	COG0262@1|root,COG0262@2|Bacteria,1MU1W@1224|Proteobacteria,1S2TQ@1236|Gammaproteobacteria,1X4M1@135614|Xanthomonadales	135614|Xanthomonadales	H	RibD C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	RibD_C
HKD2_k127_6496267_91	1449049.JONW01000005_gene1246	9.447e-10	65.0	2DPXD@1|root,333T1@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF4440)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440
HKD2_k127_6496267_51	935567.JAES01000032_gene1625	5.591e-68	238.0	COG0454@1|root,COG0456@2|Bacteria,1RJEG@1224|Proteobacteria,1SP3J@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HKD2_k127_6496267_68	477228.YO5_03967	9.585e-50	192.0	COG0103@1|root,COG0103@2|Bacteria,1RD4A@1224|Proteobacteria,1S3Q7@1236|Gammaproteobacteria,1Z2R9@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	J	Belongs to the universal ribosomal protein uS9 family	rpsI	GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02996	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S9
HKD2_k127_6496267_56	1263831.F543_13130	2.022e-63	222.0	COG0102@1|root,COG0102@2|Bacteria,1RA11@1224|Proteobacteria,1S280@1236|Gammaproteobacteria,1Y83E@135625|Pasteurellales	135625|Pasteurellales	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly	rplM	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02871	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13
HKD2_k127_6496267_55	1031711.RSPO_c00654	1.518e-65	235.0	COG2941@1|root,COG2941@2|Bacteria,1RAA1@1224|Proteobacteria,2VQRE@28216|Betaproteobacteria,1K1RC@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol	coq7	-	-	ko:K06134	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00128	R04984,R08775	RC01254	ko00000,ko00001,ko00002,ko01000	-	-	-	COQ7
HKD2_k127_6496267_47	393595.ABO_2023	6.188e-82	280.0	COG0664@1|root,COG0664@2|Bacteria,1MXID@1224|Proteobacteria,1RMIZ@1236|Gammaproteobacteria,1XH7Z@135619|Oceanospirillales	135619|Oceanospirillales	K	COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases	-	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	Crp,HTH_Crp_2,cNMP_binding
HKD2_k127_6496267_33	1198232.CYCME_0421	5.642e-110	360.0	COG0036@1|root,COG0036@2|Bacteria,1MUZM@1224|Proteobacteria,1RN3K@1236|Gammaproteobacteria,46063@72273|Thiotrichales	72273|Thiotrichales	G	Belongs to the ribulose-phosphate 3-epimerase family	rpe	-	5.1.3.1	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
HKD2_k127_6496267_58	1283300.ATXB01000001_gene1280	4.579e-61	222.0	COG1076@1|root,COG1076@2|Bacteria,1N270@1224|Proteobacteria,1RP0P@1236|Gammaproteobacteria,1XEK0@135618|Methylococcales	135618|Methylococcales	O	Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host	djlA	-	-	ko:K05801	-	-	-	-	ko00000,ko03110	-	-	-	DnaJ,TerB
HKD2_k127_6496267_23	396588.Tgr7_2886	5.877e-133	432.0	COG0152@1|root,COG0152@2|Bacteria,1MUR9@1224|Proteobacteria,1RNNY@1236|Gammaproteobacteria,1WVZH@135613|Chromatiales	135613|Chromatiales	F	SAICAR synthetase	purC	-	6.3.2.6	ko:K01923	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04591	RC00064,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	SAICAR_synt
HKD2_k127_6496267_31	1121013.P873_13215	1.024e-114	379.0	COG0614@1|root,COG0614@2|Bacteria,1PK1A@1224|Proteobacteria,1RRDK@1236|Gammaproteobacteria,1X3UZ@135614|Xanthomonadales	135614|Xanthomonadales	P	ABC transporter substrate-binding protein	-	-	-	ko:K02016	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	Peripla_BP_2
HKD2_k127_6496267_42	713586.KB900536_gene2693	1.924e-92	324.0	COG1295@1|root,COG1295@2|Bacteria,1QICW@1224|Proteobacteria,1RMKI@1236|Gammaproteobacteria,1WWKW@135613|Chromatiales	135613|Chromatiales	K	ribonuclease BN	-	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Rrf2,Virul_fac_BrkB
HKD2_k127_6496267_16	314278.NB231_05806	3.064e-165	531.0	COG0312@1|root,COG0312@2|Bacteria,1MUVW@1224|Proteobacteria,1RPJF@1236|Gammaproteobacteria,1WWPA@135613|Chromatiales	135613|Chromatiales	S	modulator of DNA gyrase	-	-	-	ko:K03592	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
HKD2_k127_6496267_84	426114.THI_2499	6.395e-28	119.0	COG3028@1|root,COG3028@2|Bacteria,1MZ4R@1224|Proteobacteria,2VSGZ@28216|Betaproteobacteria,1KM7T@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Belongs to the UPF0307 family	yjgA	-	-	ko:K09889	-	-	-	-	ko00000,ko03009	-	-	-	DUF615
HKD2_k127_6496267_54	1303518.CCALI_00052	1.08e-65	236.0	COG0041@1|root,COG0041@2|Bacteria	2|Bacteria	F	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)	purE	GO:0003674,GO:0003824,GO:0004638,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0016853,GO:0016866,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034023,GO:0034641,GO:0034654,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	5.4.99.18	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07405	RC01947	ko00000,ko00001,ko00002,ko01000	-	-	iETEC_1333.ETEC_0575,iJN746.PP_5336,iPC815.YPO3076,iUTI89_1310.UTI89_C0551	AIRC
HKD2_k127_6496267_28	869210.Marky_1688	7.254e-124	407.0	COG0026@1|root,COG0026@2|Bacteria,1WITC@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	F	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)	purK	-	6.3.4.18	ko:K01589	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07404	RC01927	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp
HKD2_k127_6496267_44	396588.Tgr7_2396	1.26e-90	313.0	COG1716@1|root,COG3267@1|root,COG1716@2|Bacteria,COG3267@2|Bacteria,1MU3G@1224|Proteobacteria,1RMI0@1236|Gammaproteobacteria,1WWX7@135613|Chromatiales	135613|Chromatiales	U	Type II secretory pathway component ExeA	-	-	-	ko:K02450,ko:K12283	-	M00331	-	-	ko00000,ko00002,ko02044	9.B.42	-	-	AAA_22
HKD2_k127_6496267_5	572477.Alvin_2520	8.044e-209	665.0	COG0312@1|root,COG0312@2|Bacteria,1MUSK@1224|Proteobacteria,1RMA5@1236|Gammaproteobacteria,1WWCQ@135613|Chromatiales	135613|Chromatiales	S	modulator of DNA gyrase	tldD	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
HKD2_k127_6496267_39	572477.Alvin_2521	2.341e-95	320.0	COG0388@1|root,COG0388@2|Bacteria,1MUUB@1224|Proteobacteria,1RNVZ@1236|Gammaproteobacteria,1WW30@135613|Chromatiales	135613|Chromatiales	S	Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase	-	-	-	ko:K11206	-	-	-	-	ko00000,ko01000	-	-	-	CN_hydrolase
HKD2_k127_6496267_36	713586.KB900536_gene1091	1.55e-100	372.0	COG3164@1|root,COG3164@2|Bacteria,1MXWF@1224|Proteobacteria,1RNUK@1236|Gammaproteobacteria,1WXQJ@135613|Chromatiales	135613|Chromatiales	S	Protein of unknown function	-	-	-	-	-	-	-	-	-	-	-	-	AsmA_2,DUF3971
HKD2_k127_6496267_12	519989.ECTPHS_02996	6.232e-192	619.0	COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,1RMIW@1236|Gammaproteobacteria,1WW9V@135613|Chromatiales	135613|Chromatiales	J	TIGRFAM ribonuclease, Rne Rng family	-	-	-	ko:K08301	-	-	-	-	ko00000,ko01000,ko03009,ko03019	-	-	-	RNase_E_G,S1
HKD2_k127_6496267_61	713586.KB900536_gene1093	1.265e-57	207.0	COG0424@1|root,COG0424@2|Bacteria,1RH6H@1224|Proteobacteria,1S41D@1236|Gammaproteobacteria,1WY2J@135613|Chromatiales	135613|Chromatiales	D	Maf-like protein	-	-	-	ko:K06287	-	-	-	-	ko00000	-	-	-	Maf
HKD2_k127_6496267_78	314285.KT71_08279	2.917e-37	161.0	COG1764@1|root,COG1764@2|Bacteria,1RJIP@1224|Proteobacteria,1S6QM@1236|Gammaproteobacteria,1J9ZC@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	O	redox protein, regulator of disulfide bond formation	-	-	-	-	-	-	-	-	-	-	-	-	OsmC
HKD2_k127_6496267_75	1492922.GY26_12535	4.092e-39	151.0	COG1576@1|root,COG1576@2|Bacteria,1R9Z2@1224|Proteobacteria,1S1ZY@1236|Gammaproteobacteria,1J6C3@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA	rlmH	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042802,GO:0042803,GO:0043021,GO:0043022,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0044877,GO:0046483,GO:0046983,GO:0070037,GO:0070038,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.177	ko:K00783	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SPOUT_MTase
HKD2_k127_6496267_79	519989.ECTPHS_03011	1.234e-34	143.0	COG0799@1|root,COG0799@2|Bacteria,1MZEF@1224|Proteobacteria,1S8W3@1236|Gammaproteobacteria,1WYQV@135613|Chromatiales	135613|Chromatiales	J	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation	rsfS	-	-	ko:K09710	-	-	-	-	ko00000,ko03009	-	-	-	RsfS
HKD2_k127_6496267_60	566466.NOR53_2825	3.263e-60	227.0	COG1057@1|root,COG1057@2|Bacteria,1RD0J@1224|Proteobacteria,1RP00@1236|Gammaproteobacteria,1J982@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	H	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)	nadD	GO:0000309,GO:0003674,GO:0003824,GO:0004515,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019365,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0034355,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0043094,GO:0043173,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	2.7.7.18,3.5.4.4	ko:K00969,ko:K01488	ko00230,ko00760,ko01100,ko05340,map00230,map00760,map01100,map05340	M00115	R00137,R01560,R02556,R03005	RC00002,RC00477	ko00000,ko00001,ko00002,ko01000	-	-	iECUMN_1333.ECUMN_0733,iJN746.PP_4810,iPC815.YPO2607,iSbBS512_1146.SbBS512_E0612	CTP_transf_like
HKD2_k127_6496267_50	1121921.KB898706_gene3095	4.98e-69	246.0	COG1466@1|root,COG1466@2|Bacteria,1MWYT@1224|Proteobacteria,1RQRE@1236|Gammaproteobacteria,2PMXI@256005|Alteromonadales genera incertae sedis	1236|Gammaproteobacteria	L	DNA polymerase III, delta subunit	holA	GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0032991,GO:0034641,GO:0034645,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:1901360,GO:1901576,GO:1902494,GO:1990234	2.7.7.7	ko:K02340	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delt_C,DNA_pol3_delta
HKD2_k127_6496267_17	1163409.UUA_13590	1.077e-151	484.0	COG0596@1|root,COG0596@2|Bacteria,1MWW8@1224|Proteobacteria,1RMKF@1236|Gammaproteobacteria,1X32H@135614|Xanthomonadales	135614|Xanthomonadales	E	Belongs to the peptidase S33 family	pip	-	3.4.11.5	ko:K01259	ko00330,map00330	-	R00135	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Abhydrolase_1
HKD2_k127_6496267_88	1121013.P873_09830	7.746e-15	82.0	COG2980@1|root,COG2980@2|Bacteria,1NGPX@1224|Proteobacteria,1SGKQ@1236|Gammaproteobacteria,1X75Y@135614|Xanthomonadales	135614|Xanthomonadales	M	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane	lptE	-	-	ko:K03643	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	LptE
HKD2_k127_6496267_1	323848.Nmul_A0511	0.0	1225.0	COG0495@1|root,COG0495@2|Bacteria,1MV47@1224|Proteobacteria,2VH2J@28216|Betaproteobacteria,372EP@32003|Nitrosomonadales	28216|Betaproteobacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
HKD2_k127_6496267_49	314278.NB231_10443	5.002e-74	269.0	COG0491@1|root,COG0491@2|Bacteria,1MUXF@1224|Proteobacteria,1RP5I@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	COG0491 Zn-dependent hydrolases, including glyoxylases	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HKD2_k127_6496267_26	105559.Nwat_0339	1.337e-126	422.0	COG0815@1|root,COG0815@2|Bacteria,1MUBU@1224|Proteobacteria,1RM8M@1236|Gammaproteobacteria,1WWSQ@135613|Chromatiales	135613|Chromatiales	M	Transfers the fatty acyl group on membrane lipoproteins	lnt	-	-	ko:K03820	-	-	-	-	ko00000,ko01000	-	GT2	-	CN_hydrolase
HKD2_k127_6496267_40	572477.Alvin_2682	1.563e-94	328.0	COG4535@1|root,COG4535@2|Bacteria,1QTU8@1224|Proteobacteria,1RMKX@1236|Gammaproteobacteria,1WW4G@135613|Chromatiales	135613|Chromatiales	P	PFAM CBS domain	-	-	-	ko:K06189	-	-	-	-	ko00000,ko02000	9.A.40.1.2	-	-	CBS,CorC_HlyC
HKD2_k127_6496267_80	1163408.UU9_13286	9.081e-34	141.0	COG0319@1|root,COG0319@2|Bacteria,1MZ67@1224|Proteobacteria,1S6BS@1236|Gammaproteobacteria,1X6SP@135614|Xanthomonadales	135614|Xanthomonadales	J	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA	ybeY	-	-	ko:K07042	-	-	-	-	ko00000,ko03009	-	-	-	UPF0054
HKD2_k127_6496267_27	396588.Tgr7_2291	1.38e-124	413.0	COG1702@1|root,COG1702@2|Bacteria,1MVDV@1224|Proteobacteria,1RP2Y@1236|Gammaproteobacteria,1WW3U@135613|Chromatiales	135613|Chromatiales	T	PFAM PhoH family protein	-	-	-	ko:K06217	-	-	-	-	ko00000	-	-	-	PhoH
HKD2_k127_6496267_6	713586.KB900536_gene1139	5.785e-203	646.0	COG0621@1|root,COG0621@2|Bacteria,1MURS@1224|Proteobacteria,1RMD8@1236|Gammaproteobacteria,1WWN1@135613|Chromatiales	135613|Chromatiales	J	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine	miaB	-	2.8.4.3	ko:K06168	-	-	R10645,R10646,R10647	RC00003,RC00980,RC03221,RC03222	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
HKD2_k127_6496267_66	1415778.JQMM01000001_gene1204	2.761e-53	192.0	COG0629@1|root,COG0629@2|Bacteria,1RCWT@1224|Proteobacteria,1S3WP@1236|Gammaproteobacteria,1J5PI@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	L	Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism	ssb	-	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
HKD2_k127_6496267_46	1260251.SPISAL_07330	6.858e-88	304.0	COG0477@1|root,COG2814@2|Bacteria,1MVSH@1224|Proteobacteria,1RN70@1236|Gammaproteobacteria,1WXE2@135613|Chromatiales	135613|Chromatiales	EGP	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
HKD2_k127_6496267_0	396588.Tgr7_2295	0.0	1428.0	COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,1RMS9@1236|Gammaproteobacteria,1WX68@135613|Chromatiales	135613|Chromatiales	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
HKD2_k127_6496267_87	1123226.KB899289_gene987	7.797e-19	94.0	COG5628@1|root,COG5628@2|Bacteria,1VAGU@1239|Firmicutes,4HHK0@91061|Bacilli,26QQ8@186822|Paenibacillaceae	91061|Bacilli	S	Acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HKD2_k127_6496267_22	522373.Smlt3861	3.774e-137	451.0	COG0006@1|root,COG0006@2|Bacteria,1MURT@1224|Proteobacteria,1RMKT@1236|Gammaproteobacteria,1X3Z6@135614|Xanthomonadales	135614|Xanthomonadales	E	Splits dipeptides with a prolyl residue in the C- terminal position	pepQ	-	3.4.13.9	ko:K01271	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
HKD2_k127_6496267_76	591023.AM202_04172	7.526e-39	153.0	COG1970@1|root,COG1970@2|Bacteria,1RHG8@1224|Proteobacteria,1S3PD@1236|Gammaproteobacteria,1Y8SI@135625|Pasteurellales	135625|Pasteurellales	M	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell	mscL	-	-	ko:K03282	-	-	-	-	ko00000,ko02000	1.A.22.1	-	-	MscL
HKD2_k127_6496267_72	1028307.EAE_04825	2.721e-43	164.0	COG0203@1|root,COG0203@2|Bacteria,1RCWN@1224|Proteobacteria,1S3QK@1236|Gammaproteobacteria,3X29H@547|Enterobacter	1236|Gammaproteobacteria	J	Ribosomal protein L17	rplQ	GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02879	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L17
HKD2_k127_6496267_19	1122212.AULO01000014_gene1219	1.296e-147	473.0	COG0202@1|root,COG0202@2|Bacteria,1MU75@1224|Proteobacteria,1RMU3@1236|Gammaproteobacteria,1XH9U@135619|Oceanospirillales	135619|Oceanospirillales	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA	-	2.7.7.6	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L
HKD2_k127_6496267_45	1109445.AGSX01000044_gene3476	5.613e-90	300.0	COG0522@1|root,COG0522@2|Bacteria,1MW0U@1224|Proteobacteria,1RQ38@1236|Gammaproteobacteria,1Z219@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit	rpsD	GO:0000028,GO:0000900,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006355,GO:0006412,GO:0006417,GO:0006446,GO:0006450,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010608,GO:0010628,GO:0010629,GO:0015935,GO:0016043,GO:0017148,GO:0019219,GO:0019222,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030371,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0031554,GO:0031564,GO:0032268,GO:0032269,GO:0032270,GO:0032991,GO:0034248,GO:0034249,GO:0034250,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043244,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045182,GO:0045727,GO:0045903,GO:0045947,GO:0048027,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051172,GO:0051173,GO:0051246,GO:0051247,GO:0051248,GO:0051252,GO:0060255,GO:0065003,GO:0065007,GO:0065008,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0080090,GO:0090079,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903506,GO:1990145,GO:1990904,GO:2000112,GO:2000113,GO:2001141	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S4,S4
HKD2_k127_6496267_59	935567.JAES01000037_gene2024	5.57e-61	212.0	COG0100@1|root,COG0100@2|Bacteria,1RD0A@1224|Proteobacteria,1S3Q2@1236|Gammaproteobacteria,1X6JV@135614|Xanthomonadales	135614|Xanthomonadales	J	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome	rpsK	GO:0000028,GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0048027,GO:0065003,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02948	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S11
HKD2_k127_6496267_70	396588.Tgr7_2302	4.543e-48	175.0	COG0099@1|root,COG0099@2|Bacteria,1RD1G@1224|Proteobacteria,1S3NX@1236|Gammaproteobacteria,1WYHF@135613|Chromatiales	135613|Chromatiales	J	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits	rpsM	-	-	ko:K02952	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13
HKD2_k127_6496267_92	926550.CLDAP_03870	4.017e-08	66.0	COG0257@1|root,COG0257@2|Bacteria	2|Bacteria	J	Belongs to the bacterial ribosomal protein bL36 family	rpmJ	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02919	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L36
HKD2_k127_6496267_13	395493.BegalDRAFT_2604	2.305e-191	606.0	COG0201@1|root,COG0201@2|Bacteria,1MVU7@1224|Proteobacteria,1RNJV@1236|Gammaproteobacteria,45ZXN@72273|Thiotrichales	72273|Thiotrichales	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	-	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	SecY
HKD2_k127_6496267_69	1123400.KB904817_gene1482	8.303e-49	179.0	COG0200@1|root,COG0200@2|Bacteria,1RDC8@1224|Proteobacteria,1S3P6@1236|Gammaproteobacteria,460T4@72273|Thiotrichales	72273|Thiotrichales	J	binds to the 23S rRNA	rplO	-	-	ko:K02876	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27A
HKD2_k127_6496267_89	1112274.KI911560_gene1473	1.907e-11	73.0	COG1841@1|root,COG1841@2|Bacteria,1N6ZE@1224|Proteobacteria,2VVPT@28216|Betaproteobacteria,2KNAI@206350|Nitrosomonadales	206350|Nitrosomonadales	J	TIGRFAM ribosomal protein L30	rpmD	-	-	ko:K02907	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L30
HKD2_k127_6496267_52	1122604.JONR01000006_gene2673	3.134e-67	233.0	COG0098@1|root,COG0098@2|Bacteria,1MUS4@1224|Proteobacteria,1RNEV@1236|Gammaproteobacteria,1X5KF@135614|Xanthomonadales	135614|Xanthomonadales	J	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body	rpsE	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02988	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S5,Ribosomal_S5_C
HKD2_k127_6496267_74	326297.Sama_0229	5.352e-40	151.0	COG0256@1|root,COG0256@2|Bacteria,1RGY7@1224|Proteobacteria,1S5V2@1236|Gammaproteobacteria,2QBWU@267890|Shewanellaceae	1236|Gammaproteobacteria	J	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance	rplR	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02881	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18p
HKD2_k127_6496267_57	283942.IL1901	2.452e-63	221.0	COG0097@1|root,COG0097@2|Bacteria,1R9YZ@1224|Proteobacteria,1S1Z1@1236|Gammaproteobacteria,2QF6M@267893|Idiomarinaceae	1236|Gammaproteobacteria	J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center	rplF	GO:0000027,GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070180,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02933	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L6
HKD2_k127_6496267_62	519989.ECTPHS_13128	1.363e-56	199.0	COG0096@1|root,COG0096@2|Bacteria,1RDG3@1224|Proteobacteria,1S452@1236|Gammaproteobacteria,1WXYT@135613|Chromatiales	135613|Chromatiales	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit	rpsH	-	-	ko:K02994	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8
HKD2_k127_6496267_81	1198232.CYCME_0758	2.25e-31	131.0	COG0199@1|root,COG0199@2|Bacteria,1MZDT@1224|Proteobacteria,1S62N@1236|Gammaproteobacteria,460WT@72273|Thiotrichales	72273|Thiotrichales	J	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site	rpsN	-	-	ko:K02954	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S14
HKD2_k127_6496267_65	1195246.AGRI_12132	2.948e-54	192.0	COG0094@1|root,COG0094@2|Bacteria,1MUU9@1224|Proteobacteria,1RPE1@1236|Gammaproteobacteria,464A7@72275|Alteromonadaceae	1236|Gammaproteobacteria	J	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits	rplE	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02931	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L5,Ribosomal_L5_C
HKD2_k127_6514170_2	82995.CR62_03715	2.747e-181	578.0	COG3104@1|root,COG3104@2|Bacteria,1QXBE@1224|Proteobacteria,1RNVV@1236|Gammaproteobacteria,401XX@613|Serratia	1236|Gammaproteobacteria	E	amino acid peptide transporter	ydgR	-	-	ko:K03305,ko:K06218	-	-	-	-	ko00000,ko02048	2.A.17	-	-	MFS_1,PTR2
HKD2_k127_6514170_5	1122604.JONR01000010_gene3967	6.068e-121	405.0	COG1020@1|root,COG1020@2|Bacteria,1N7HY@1224|Proteobacteria,1RQJX@1236|Gammaproteobacteria,1X3CA@135614|Xanthomonadales	135614|Xanthomonadales	Q	Protein of unknown function (DUF1298)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1298,WES_acyltransf
HKD2_k127_6514170_7	246200.SPO3832	1.882e-78	273.0	COG2423@1|root,COG2423@2|Bacteria,1PPG5@1224|Proteobacteria,2V8U0@28211|Alphaproteobacteria,4NDIB@97050|Ruegeria	28211|Alphaproteobacteria	E	Ornithine cyclodeaminase/mu-crystallin family	-	-	4.3.1.12	ko:K01750	ko00330,ko01110,ko01130,ko01230,map00330,map01110,map01130,map01230	-	R00671	RC00354	ko00000,ko00001,ko01000	-	-	-	OCD_Mu_crystall
HKD2_k127_6514170_6	1163617.SCD_n01943	2.454e-108	373.0	COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,2VIK8@28216|Betaproteobacteria	28216|Betaproteobacteria	BQ	histone deacetylase	hda	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
HKD2_k127_6514170_0	472759.Nhal_2012	9.519e-261	831.0	COG0045@1|root,COG0454@1|root,COG1042@1|root,COG0045@2|Bacteria,COG0456@2|Bacteria,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,1RPXX@1236|Gammaproteobacteria,1WWWU@135613|Chromatiales	135613|Chromatiales	C	CoA-binding domain protein	-	-	-	ko:K09181	-	-	-	-	ko00000	-	-	-	ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig
HKD2_k127_6514170_8	1123257.AUFV01000026_gene1	4.011e-78	276.0	COG2207@1|root,COG2207@2|Bacteria,1QQ61@1224|Proteobacteria,1S3GG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	COG2207 AraC-type DNA-binding domain-containing proteins	-	-	-	-	-	-	-	-	-	-	-	-	Arabinose_bd,HTH_18
HKD2_k127_6514170_1	1123257.AUFV01000026_gene2	2.935e-229	725.0	COG2072@1|root,COG2072@2|Bacteria,1MUQH@1224|Proteobacteria,1RPJY@1236|Gammaproteobacteria,1X4PP@135614|Xanthomonadales	135614|Xanthomonadales	P	Flavin-binding monooxygenase-like	-	-	-	-	-	-	-	-	-	-	-	-	FMO-like
HKD2_k127_6514170_3	1370120.AUWR01000005_gene2244	1.318e-143	471.0	COG0208@1|root,COG0208@2|Bacteria,2GJKZ@201174|Actinobacteria,2338B@1762|Mycobacteriaceae	201174|Actinobacteria	F	P-aminobenzoate N-oxygenase AurF	-	-	-	-	-	-	-	-	-	-	-	-	AurF
HKD2_k127_6514170_4	1384054.N790_06075	1.994e-122	411.0	COG3203@1|root,COG3203@2|Bacteria,1MX4Q@1224|Proteobacteria,1RY5B@1236|Gammaproteobacteria,1X3S0@135614|Xanthomonadales	135614|Xanthomonadales	M	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6514170_9	1045855.DSC_00695	3.939e-74	255.0	COG2197@1|root,COG2197@2|Bacteria,1P4TD@1224|Proteobacteria,1RU35@1236|Gammaproteobacteria,1X3JV@135614|Xanthomonadales	135614|Xanthomonadales	KT	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain	tcsR	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HKD2_k127_6514170_10	935863.AWZR01000001_gene1751	1.516e-25	111.0	COG0591@1|root,COG0642@1|root,COG0745@1|root,COG0591@2|Bacteria,COG0745@2|Bacteria,COG2205@2|Bacteria,1MUY7@1224|Proteobacteria,1RP2U@1236|Gammaproteobacteria,1X43U@135614|Xanthomonadales	135614|Xanthomonadales	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_7,Response_reg
HKD2_k127_6562286_12	1049564.TevJSym_ac02050	2.632e-27	115.0	COG0358@1|root,COG0358@2|Bacteria,1MUHC@1224|Proteobacteria,1RMGA@1236|Gammaproteobacteria,1J4QZ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	GO:0003674,GO:0003824,GO:0003896,GO:0003899,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006269,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB_bind,DnaG_DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2
HKD2_k127_6562286_9	1163409.UUA_10596	4.722e-48	179.0	COG1610@1|root,COG1610@2|Bacteria,1RGZS@1224|Proteobacteria,1S61A@1236|Gammaproteobacteria,1X6H1@135614|Xanthomonadales	135614|Xanthomonadales	S	Glutamyl-tRNA amidotransferase	-	-	-	ko:K09117	-	-	-	-	ko00000	-	-	-	YqeY
HKD2_k127_6562286_14	767434.Fraau_2730	1.569e-22	98.0	COG0828@1|root,COG0828@2|Bacteria,1MZCC@1224|Proteobacteria,1S8QZ@1236|Gammaproteobacteria,1X7FD@135614|Xanthomonadales	135614|Xanthomonadales	J	Belongs to the bacterial ribosomal protein bS21 family	rpsU	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:1990904	-	ko:K02970	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S21
HKD2_k127_6562286_2	713586.KB900536_gene1824	1.585e-137	447.0	COG0533@1|root,COG0533@2|Bacteria,1MU6S@1224|Proteobacteria,1RN8M@1236|Gammaproteobacteria,1WWRX@135613|Chromatiales	135613|Chromatiales	O	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction	tsaD	-	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
HKD2_k127_6562286_10	395493.BegalDRAFT_2718	1.345e-42	162.0	COG1539@1|root,COG1539@2|Bacteria,1MZ8Z@1224|Proteobacteria,1S9B2@1236|Gammaproteobacteria,46173@72273|Thiotrichales	72273|Thiotrichales	H	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin	-	-	1.13.11.81,4.1.2.25,5.1.99.8	ko:K01633	ko00790,ko01100,map00790,map01100	M00126,M00840	R03504,R11037,R11073	RC00721,RC00943,RC01479,RC03333,RC03334	ko00000,ko00001,ko00002,ko01000	-	-	-	FolB
HKD2_k127_6562286_11	472759.Nhal_0030	8.684e-38	152.0	COG0801@1|root,COG0801@2|Bacteria,1RHNN@1224|Proteobacteria,1S62M@1236|Gammaproteobacteria,1WYX8@135613|Chromatiales	135613|Chromatiales	H	PFAM 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK	-	-	2.7.6.3	ko:K00950	ko00790,ko01100,map00790,map01100	M00126,M00841	R03503	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	HPPK
HKD2_k127_6562286_6	1123392.AQWL01000006_gene565	2.242e-87	298.0	COG1028@1|root,COG1028@2|Bacteria,1MUUV@1224|Proteobacteria,2VK0U@28216|Betaproteobacteria,1KRK0@119069|Hydrogenophilales	119069|Hydrogenophilales	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.5.1.33	ko:K03793	-	-	-	-	ko00000,ko01000	-	-	-	adh_short_C2
HKD2_k127_6562286_4	765912.Thimo_0563	8.297e-114	381.0	COG1565@1|root,COG1565@2|Bacteria,1N3CJ@1224|Proteobacteria,1RYCJ@1236|Gammaproteobacteria,1WWJG@135613|Chromatiales	135613|Chromatiales	S	Putative S-adenosyl-L-methionine-dependent methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_28
HKD2_k127_6562286_1	396588.Tgr7_0331	5.883e-155	501.0	COG0617@1|root,COG0617@2|Bacteria,1MU2X@1224|Proteobacteria,1RPFJ@1236|Gammaproteobacteria,1WWKR@135613|Chromatiales	135613|Chromatiales	J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. Also shows phosphatase, 2'- nucleotidase and 2',3'-cyclic phosphodiesterase activities. These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases	cca	-	2.7.7.72	ko:K00974	ko03013,map03013	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko00001,ko01000,ko03016	-	-	-	HD,PolyA_pol,PolyA_pol_RNAbd
HKD2_k127_6562286_7	1502852.FG94_03246	1.32e-84	295.0	COG4324@1|root,COG4324@2|Bacteria,1N0FE@1224|Proteobacteria,2VH73@28216|Betaproteobacteria,476PV@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Putative aminopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Aminopep
HKD2_k127_6562286_5	713586.KB900536_gene2508	3.265e-92	315.0	COG0702@1|root,COG0702@2|Bacteria,1MW54@1224|Proteobacteria,1RNS7@1236|Gammaproteobacteria,1WXE7@135613|Chromatiales	135613|Chromatiales	GM	NAD-dependent epimerase dehydratase	-	-	1.6.5.3,1.6.99.3	ko:K00329,ko:K00356	ko00190,map00190	-	R11945	RC00061	ko00000,ko00001,ko01000	-	-	-	Epimerase,NAD_binding_10
HKD2_k127_6562286_3	396595.TK90_2479	4.474e-137	449.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,1RN9T@1236|Gammaproteobacteria,1WX0Q@135613|Chromatiales	135613|Chromatiales	O	Belongs to the peptidase S1C family	-	-	3.4.21.107	ko:K04771,ko:K04772	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ,PDZ_2,Trypsin_2
HKD2_k127_6562286_0	1384056.N787_12005	0.0	1143.0	COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,1RQUR@1236|Gammaproteobacteria,1X2Z8@135614|Xanthomonadales	135614|Xanthomonadales	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	-	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	LAGLIDADG_3,Ribonuc_red_lgC,Ribonuc_red_lgN
HKD2_k127_6562286_8	1255043.TVNIR_3567	1.566e-57	215.0	COG0209@1|root,COG0209@2|Bacteria,1P4EH@1224|Proteobacteria,1RP1A@1236|Gammaproteobacteria	1236|Gammaproteobacteria	F	COG0209 Ribonucleotide reductase, alpha subunit	nrdJb	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6562286_13	1112274.KI911560_gene1289	5.537e-24	103.0	COG0209@1|root,COG0209@2|Bacteria,1P4EH@1224|Proteobacteria,2VZ6P@28216|Betaproteobacteria,2KMFP@206350|Nitrosomonadales	206350|Nitrosomonadales	F	COG0209 Ribonucleotide reductase, alpha subunit	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6574722_1	1297742.A176_00861	1.134e-27	117.0	COG0642@1|root,COG2205@2|Bacteria,1QX6V@1224|Proteobacteria,43BZK@68525|delta/epsilon subdivisions,2X7AC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_4
HKD2_k127_6574722_0	1125863.JAFN01000001_gene2828	2.684e-133	438.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,43AW1@68525|delta/epsilon subdivisions,2X6A7@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Bacterial regulatory protein, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD2_k127_6615791_0	765912.Thimo_2324	5.04e-34	136.0	COG4566@1|root,COG4566@2|Bacteria,1N6WR@1224|Proteobacteria,1S0TV@1236|Gammaproteobacteria,1WXDV@135613|Chromatiales	135613|Chromatiales	K	response regulator receiver	-	-	-	ko:K13041	ko02020,map02020	M00514	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	GerE,Response_reg
HKD2_k127_6640243_0	1123073.KB899243_gene459	0.0	1082.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1X3JU@135614|Xanthomonadales	135614|Xanthomonadales	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
HKD2_k127_6640243_1	404380.Gbem_0064	3.683e-98	335.0	COG0845@1|root,COG0845@2|Bacteria,1MW65@1224|Proteobacteria,42NJG@68525|delta/epsilon subdivisions,2WJ8R@28221|Deltaproteobacteria,43US6@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Biotin-lipoyl like	-	-	-	ko:K07799	ko02020,map02020	M00648	-	-	ko00000,ko00001,ko00002,ko02000	8.A.1	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
HKD2_k127_6640243_2	93220.LV28_07610	1.25e-94	318.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2VI4Q@28216|Betaproteobacteria,1K0B4@119060|Burkholderiaceae	28216|Betaproteobacteria	O	Belongs to the peptidase S1C family	mucD	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
HKD2_k127_6656358_5	1122963.AUHB01000001_gene634	1.249e-113	371.0	COG0174@1|root,COG0174@2|Bacteria,1MU6V@1224|Proteobacteria,2TRCP@28211|Alphaproteobacteria,36Z9B@31993|Methylocystaceae	28211|Alphaproteobacteria	E	Glutamine synthetase, catalytic domain	glnA1	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C
HKD2_k127_6656358_0	382245.ASA_0173	2.173e-207	655.0	COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,1RNW9@1236|Gammaproteobacteria,1Y586@135624|Aeromonadales	135624|Aeromonadales	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.113	ko:K12256	ko00330,ko01100,map00330,map01100	-	R08714	RC00008,RC00062	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_3
HKD2_k127_6656358_2	1454004.AW11_03118	1.133e-158	510.0	COG0687@1|root,COG0687@2|Bacteria,1MUYW@1224|Proteobacteria,2VJDV@28216|Betaproteobacteria,1KQTZ@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	E	Required for the activity of the bacterial periplasmic transport system of putrescine	potF	-	-	ko:K02055,ko:K11069,ko:K11073	ko02010,ko02024,map02010,map02024	M00193,M00299,M00300	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11,3.A.1.11.1,3.A.1.11.2	-	-	SBP_bac_8
HKD2_k127_6656358_3	1454004.AW11_03118	2.717e-152	492.0	COG0687@1|root,COG0687@2|Bacteria,1MUYW@1224|Proteobacteria,2VJDV@28216|Betaproteobacteria,1KQTZ@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	E	Required for the activity of the bacterial periplasmic transport system of putrescine	potF	-	-	ko:K02055,ko:K11069,ko:K11073	ko02010,ko02024,map02010,map02024	M00193,M00299,M00300	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11,3.A.1.11.1,3.A.1.11.2	-	-	SBP_bac_8
HKD2_k127_6656358_1	1454004.AW11_03117	4.797e-170	541.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2VHEJ@28216|Betaproteobacteria,1KQHP@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	E	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system	potA	-	3.6.3.31	ko:K11072,ko:K11076	ko02010,map02010	M00299,M00300	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.11.1,3.A.1.11.2	-	-	ABC_tran,TOBE_2
HKD2_k127_6656358_4	1454004.AW11_03116	5.157e-130	423.0	COG1176@1|root,COG1176@2|Bacteria,1MVGM@1224|Proteobacteria,2VHYC@28216|Betaproteobacteria,1KQVC@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	U	Binding-protein-dependent transport system inner membrane component	potH	-	-	ko:K11071,ko:K11075	ko02010,map02010	M00299,M00300	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.1,3.A.1.11.2	-	-	BPD_transp_1
HKD2_k127_6656358_6	1110502.TMO_0287	1.563e-74	256.0	COG1177@1|root,COG1177@2|Bacteria,1MVC5@1224|Proteobacteria,2TRRJ@28211|Alphaproteobacteria,2JQ7X@204441|Rhodospirillales	204441|Rhodospirillales	E	COG1177 ABC-type spermidine putrescine transport system, permease component II	potI	-	-	ko:K11074	ko02010,map02010	M00300	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.2	-	-	BPD_transp_1
HKD2_k127_6656908_1	713586.KB900536_gene59	2.128e-111	372.0	COG0285@1|root,COG0285@2|Bacteria,1MVCH@1224|Proteobacteria,1RMB0@1236|Gammaproteobacteria,1WWQD@135613|Chromatiales	135613|Chromatiales	H	Belongs to the folylpolyglutamate synthase family	-	-	6.3.2.12,6.3.2.17	ko:K11754	ko00790,ko01100,map00790,map01100	M00126,M00841	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	Mur_ligase_M
HKD2_k127_6656908_0	1158756.AQXQ01000008_gene2469	3.651e-130	421.0	COG0777@1|root,COG0777@2|Bacteria,1MW8G@1224|Proteobacteria,1RNDS@1236|Gammaproteobacteria,1WW2U@135613|Chromatiales	135613|Chromatiales	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA	accD	-	2.1.3.15,6.4.1.2	ko:K01963	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
HKD2_k127_6656908_2	631362.Thi970DRAFT_04971	2.866e-85	295.0	COG0101@1|root,COG0101@2|Bacteria,1MUYI@1224|Proteobacteria,1RMK2@1236|Gammaproteobacteria,1WX2M@135613|Chromatiales	135613|Chromatiales	J	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs	truA	-	5.4.99.12	ko:K06173	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PseudoU_synth_1
HKD2_k127_6656908_3	1149133.ppKF707_1745	1.293e-13	75.0	COG3170@1|root,COG3170@2|Bacteria,1MXV7@1224|Proteobacteria,1RMM5@1236|Gammaproteobacteria,1YCTA@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	NU	COG3170 Tfp pilus assembly protein FimV	fimV	-	-	ko:K08086	-	-	-	-	ko00000	-	-	-	LysM,TPR_19
HKD2_k127_6690322_18	1158756.AQXQ01000012_gene1515	2.923e-25	111.0	COG1534@1|root,COG1534@2|Bacteria,1N8K5@1224|Proteobacteria,1SDIM@1236|Gammaproteobacteria,1WYSK@135613|Chromatiales	135613|Chromatiales	J	CRS1_YhbY	-	-	-	ko:K07574	-	-	-	-	ko00000,ko03009	-	-	-	CRS1_YhbY
HKD2_k127_6690322_12	1385515.N791_12025	1.606e-71	249.0	COG0293@1|root,COG0293@2|Bacteria,1MW1C@1224|Proteobacteria,1RN5M@1236|Gammaproteobacteria,1X4P6@135614|Xanthomonadales	135614|Xanthomonadales	J	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit	ftsJ	-	2.1.1.166	ko:K02427	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ
HKD2_k127_6690322_0	765914.ThisiDRAFT_2001	2.269e-306	949.0	COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,1RME8@1236|Gammaproteobacteria,1WX7K@135613|Chromatiales	135613|Chromatiales	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
HKD2_k127_6690322_6	519989.ECTPHS_07017	3.368e-93	317.0	COG0294@1|root,COG0294@2|Bacteria,1MUIR@1224|Proteobacteria,1RM8G@1236|Gammaproteobacteria,1WXND@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives	folP	-	2.5.1.15	ko:K00796	ko00790,ko01100,map00790,map01100	M00126,M00841	R03066,R03067	RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
HKD2_k127_6690322_4	1116472.MGMO_88c00330	2.027e-163	529.0	COG1109@1|root,COG1109@2|Bacteria,1MU24@1224|Proteobacteria,1RMR2@1236|Gammaproteobacteria,1XEX8@135618|Methylococcales	135618|Methylococcales	G	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate	glmM	-	5.4.2.10	ko:K03431	ko00520,ko01100,ko01130,map00520,map01100,map01130	-	R02060	RC00408	ko00000,ko00001,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
HKD2_k127_6690322_7	292415.Tbd_1140	9.189e-92	307.0	COG0149@1|root,COG0149@2|Bacteria,1MWK5@1224|Proteobacteria,2VIRP@28216|Betaproteobacteria,1KRM4@119069|Hydrogenophilales	119069|Hydrogenophilales	F	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)	-	-	5.3.1.1	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01015	RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	TIM
HKD2_k127_6690322_17	396588.Tgr7_0985	2.731e-25	111.0	COG1314@1|root,COG1314@2|Bacteria,1N8MF@1224|Proteobacteria,1SD3P@1236|Gammaproteobacteria,1WZFD@135613|Chromatiales	135613|Chromatiales	U	PFAM Preprotein translocase SecG subunit	secG	-	-	ko:K03075	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecG
HKD2_k127_6690322_15	765914.ThisiDRAFT_0715	4.123e-47	172.0	COG0838@1|root,COG0838@2|Bacteria,1RGUT@1224|Proteobacteria,1S644@1236|Gammaproteobacteria,1WYJ8@135613|Chromatiales	135613|Chromatiales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoA	-	1.6.5.3	ko:K00330	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q4
HKD2_k127_6690322_8	637390.AFOH01000122_gene404	4.068e-91	310.0	COG0377@1|root,COG0377@2|Bacteria,1MUI2@1224|Proteobacteria,1RP4R@1236|Gammaproteobacteria,2NBQJ@225057|Acidithiobacillales	225057|Acidithiobacillales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	-	1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q6
HKD2_k127_6690322_11	396588.Tgr7_0988	1.673e-77	267.0	COG0852@1|root,COG0852@2|Bacteria,1MX4B@1224|Proteobacteria,1S2ET@1236|Gammaproteobacteria,1WWDD@135613|Chromatiales	135613|Chromatiales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoC	-	1.6.5.3	ko:K00332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa
HKD2_k127_6690322_1	472759.Nhal_3697	2.952e-252	780.0	COG0649@1|root,COG0649@2|Bacteria,1MVIN@1224|Proteobacteria,1RM98@1236|Gammaproteobacteria,1WWN5@135613|Chromatiales	135613|Chromatiales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoD	-	1.6.5.3	ko:K00333	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa
HKD2_k127_6690322_13	713586.KB900536_gene3047	7.872e-64	240.0	COG1905@1|root,COG1905@2|Bacteria,1MWS2@1224|Proteobacteria,1RN4C@1236|Gammaproteobacteria,1WWTG@135613|Chromatiales	135613|Chromatiales	C	TIGRFAM NADH-quinone oxidoreductase, E subunit	-	-	1.6.5.3	ko:K00334	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
HKD2_k127_6690322_3	396588.Tgr7_0991	3.57e-211	663.0	COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,1RMUD@1236|Gammaproteobacteria,1WWH3@135613|Chromatiales	135613|Chromatiales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain	nuoF	-	1.6.5.3	ko:K00335	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_51K,NADH_4Fe-4S,SLBB
HKD2_k127_6690322_2	519989.ECTPHS_07067	3.395e-248	791.0	COG1034@1|root,COG1034@2|Bacteria,1P8MN@1224|Proteobacteria,1RMUH@1236|Gammaproteobacteria,1WWAH@135613|Chromatiales	135613|Chromatiales	C	TIGRFAM NADH-quinone oxidoreductase, chain G	-	-	1.6.5.3	ko:K00336	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer2_4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
HKD2_k127_6690322_5	396588.Tgr7_0993	1.324e-145	470.0	COG1005@1|root,COG1005@2|Bacteria,1MU2R@1224|Proteobacteria,1RQE9@1236|Gammaproteobacteria,1WXDH@135613|Chromatiales	135613|Chromatiales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	nuoH	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
HKD2_k127_6690322_10	396588.Tgr7_0994	1.263e-80	270.0	COG1143@1|root,COG1143@2|Bacteria,1MV90@1224|Proteobacteria,1RN32@1236|Gammaproteobacteria,1WWN9@135613|Chromatiales	135613|Chromatiales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoI	-	1.6.5.3	ko:K00338	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer4
HKD2_k127_6690322_14	1469245.JFBG01000086_gene1619	4.732e-62	220.0	COG0839@1|root,COG0839@2|Bacteria,1MWJV@1224|Proteobacteria,1S65T@1236|Gammaproteobacteria,1WXHS@135613|Chromatiales	135613|Chromatiales	C	Belongs to the complex I subunit 6 family	nuoJ	-	1.6.5.3	ko:K00339	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q3
HKD2_k127_6690322_16	765913.ThidrDRAFT_4120	1.765e-38	155.0	COG0713@1|root,COG0713@2|Bacteria,1RH0S@1224|Proteobacteria,1S6FN@1236|Gammaproteobacteria,1WYHG@135613|Chromatiales	135613|Chromatiales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoK	-	1.6.5.3	ko:K00340	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q2
HKD2_k127_6690322_9	396595.TK90_0719	4.581e-87	291.0	COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,1RNKN@1236|Gammaproteobacteria,1WWQ6@135613|Chromatiales	135613|Chromatiales	CP	NADH-Ubiquinone oxidoreductase (complex I) chain 5 L domain protein	-	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M,Proton_antipo_N
HKD2_k127_6696659_1	1260251.SPISAL_04130	8.386e-225	725.0	COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,1RMDS@1236|Gammaproteobacteria,1WXN6@135613|Chromatiales	135613|Chromatiales	J	Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs	rne	-	3.1.26.12	ko:K08300	ko03018,map03018	M00394	-	-	ko00000,ko00001,ko00002,ko01000,ko03009,ko03019	-	-	-	RNase_E_G,S1
HKD2_k127_6696659_22	75379.Tint_1785	1.048e-54	196.0	COG0394@1|root,COG0394@2|Bacteria,1RH90@1224|Proteobacteria,2VSKW@28216|Betaproteobacteria,1KM3K@119065|unclassified Burkholderiales	28216|Betaproteobacteria	T	Low molecular weight phosphotyrosine protein phosphatase	ptpA	GO:0000271,GO:0003674,GO:0003824,GO:0004721,GO:0004725,GO:0005975,GO:0005976,GO:0006464,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009242,GO:0009987,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019538,GO:0033692,GO:0034637,GO:0034645,GO:0035335,GO:0036211,GO:0042578,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044267,GO:0046377,GO:0071704,GO:0140096,GO:1901135,GO:1901137,GO:1901564,GO:1901576	3.1.3.48	ko:K01104	-	-	-	-	ko00000,ko01000	-	-	-	LMWPc
HKD2_k127_6696659_4	1121374.KB891585_gene1873	1.416e-135	444.0	COG2133@1|root,COG2133@2|Bacteria,1MVK5@1224|Proteobacteria,1RPE8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	COG2133 Glucose sorbosone dehydrogenases	-	-	-	-	-	-	-	-	-	-	-	-	GSDH
HKD2_k127_6696659_24	1278073.MYSTI_04588	8.054e-48	177.0	COG1670@1|root,COG1670@2|Bacteria,1N18Y@1224|Proteobacteria,435YY@68525|delta/epsilon subdivisions,2X0G7@28221|Deltaproteobacteria,2Z0UB@29|Myxococcales	28221|Deltaproteobacteria	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
HKD2_k127_6696659_15	1234364.AMSF01000055_gene1093	1.457e-84	285.0	COG0625@1|root,COG0625@2|Bacteria,1MY47@1224|Proteobacteria,1RRI3@1236|Gammaproteobacteria,1X3MP@135614|Xanthomonadales	135614|Xanthomonadales	O	glutathione s-transferase	gst4	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C_2,GST_C_3,GST_N,GST_N_3
HKD2_k127_6696659_9	266264.Rmet_4038	2.321e-105	354.0	COG4705@1|root,COG4705@2|Bacteria,1MVMJ@1224|Proteobacteria,2VJTM@28216|Betaproteobacteria,1K18G@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Repeat of Unknown Function (DUF347)	-	-	-	-	-	-	-	-	-	-	-	-	DUF347
HKD2_k127_6696659_16	1123242.JH636436_gene528	8.01e-78	266.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_23,Methyltransf_25,Methyltransf_32,NUDIX,PCMT
HKD2_k127_6696659_20	1046724.KB889827_gene2811	1.748e-65	230.0	COG0122@1|root,COG0122@2|Bacteria,1MX9C@1224|Proteobacteria,1S5J1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase	-	-	3.2.2.21	ko:K01247	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
HKD2_k127_6696659_26	596151.DesfrDRAFT_1007	9.417e-34	139.0	COG0023@1|root,COG0023@2|Bacteria,1MZ8T@1224|Proteobacteria,42TW6@68525|delta/epsilon subdivisions,2WQNT@28221|Deltaproteobacteria,2MCKC@213115|Desulfovibrionales	28221|Deltaproteobacteria	J	PFAM translation initiation factor SUI1	yciH	-	-	ko:K03113	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	SUI1
HKD2_k127_6696659_11	1122604.JONR01000007_gene2869	1.785e-97	325.0	COG1187@1|root,COG1187@2|Bacteria,1MXQE@1224|Proteobacteria,1RMC7@1236|Gammaproteobacteria,1X338@135614|Xanthomonadales	135614|Xanthomonadales	J	Belongs to the pseudouridine synthase RsuA family	rluF	-	5.4.99.21	ko:K06182	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
HKD2_k127_6696659_27	583355.Caka_1725	2.206e-32	134.0	COG3952@1|root,COG3952@2|Bacteria	2|Bacteria	S	lipid-A-disaccharide synthase activity	-	-	-	-	-	-	-	-	-	-	-	-	LAB_N
HKD2_k127_6696659_17	1123354.AUDR01000015_gene195	2.323e-72	252.0	COG1212@1|root,COG1212@2|Bacteria,1MUUU@1224|Proteobacteria,2VINM@28216|Betaproteobacteria,1KRJM@119069|Hydrogenophilales	119069|Hydrogenophilales	M	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria	kdsB	-	2.7.7.38	ko:K00979	ko00540,ko01100,map00540,map01100	M00063	R03351,R11396	RC00152,RC00910	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CTP_transf_3
HKD2_k127_6696659_31	62928.azo1471	6.82e-22	96.0	COG2835@1|root,COG2835@2|Bacteria,1N6Y2@1224|Proteobacteria,2VW58@28216|Betaproteobacteria,2KXCI@206389|Rhodocyclales	206389|Rhodocyclales	S	Belongs to the UPF0434 family	-	-	-	ko:K09791	-	-	-	-	ko00000	-	-	-	Trm112p
HKD2_k127_6696659_18	1234364.AMSF01000016_gene1675	5.664e-68	244.0	COG1663@1|root,COG1663@2|Bacteria,1MU8G@1224|Proteobacteria,1RMMW@1236|Gammaproteobacteria,1X3DM@135614|Xanthomonadales	135614|Xanthomonadales	M	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)	lpxK	-	2.7.1.130	ko:K00912	ko00540,ko01100,map00540,map01100	M00060	R04657	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	LpxK
HKD2_k127_6696659_2	519989.ECTPHS_10706	9.799e-178	574.0	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,1RMUR@1236|Gammaproteobacteria,1WW89@135613|Chromatiales	135613|Chromatiales	V	Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation	msbA	-	-	ko:K11085	ko02010,map02010	-	-	-	ko00000,ko00001,ko01000,ko02000	3.A.1.106	-	-	ABC_membrane,ABC_tran
HKD2_k127_6696659_29	1122201.AUAZ01000002_gene987	1.453e-30	126.0	COG0848@1|root,COG0848@2|Bacteria,1N0ZA@1224|Proteobacteria,1S90K@1236|Gammaproteobacteria,467KB@72275|Alteromonadaceae	1236|Gammaproteobacteria	U	Biopolymer transport protein ExbD/TolR	exbD1	-	-	ko:K03559	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	ExbD
HKD2_k127_6696659_19	765914.ThisiDRAFT_0926	1.189e-65	232.0	COG0811@1|root,COG0811@2|Bacteria,1QNJ1@1224|Proteobacteria,1RQWT@1236|Gammaproteobacteria,1WX5A@135613|Chromatiales	135613|Chromatiales	U	PFAM MotA TolQ ExbB proton channel	-	-	-	ko:K03561	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	MotA_ExbB
HKD2_k127_6696659_5	243233.MCA2627	2.317e-129	443.0	COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,1MUKF@1224|Proteobacteria,1RMW6@1236|Gammaproteobacteria,1XDUM@135618|Methylococcales	135618|Methylococcales	S	Competence protein ComEC Rec2	-	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Competence,DUF4131,Lactamase_B
HKD2_k127_6696659_14	1123256.KB907926_gene914	2.315e-85	289.0	COG1136@1|root,COG1136@2|Bacteria,1MVSQ@1224|Proteobacteria,1RMWK@1236|Gammaproteobacteria,1X2X9@135614|Xanthomonadales	135614|Xanthomonadales	V	Part of the ABC transporter complex LolCDE involved in the translocation of	lolD	-	-	ko:K09810	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.125	-	-	ABC_tran
HKD2_k127_6696659_6	1123256.KB907926_gene915	3.718e-127	419.0	COG4591@1|root,COG4591@2|Bacteria,1MVV7@1224|Proteobacteria,1RMP9@1236|Gammaproteobacteria,1X2ZV@135614|Xanthomonadales	135614|Xanthomonadales	M	Lipoprotein releasing system transmembrane protein	lolC	-	-	ko:K09808	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.125	-	-	FtsX,MacB_PCD
HKD2_k127_6696659_7	765912.Thimo_0194	2.046e-117	391.0	COG4591@1|root,COG4591@2|Bacteria,1MVV7@1224|Proteobacteria,1RMP9@1236|Gammaproteobacteria,1WW0V@135613|Chromatiales	135613|Chromatiales	M	lipoprotein releasing system, transmembrane protein, LolC E family	-	-	-	ko:K09808	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.125	-	-	FtsX,MacB_PCD
HKD2_k127_6696659_34	1056820.KB900653_gene3063	4.471e-10	73.0	2ENKU@1|root,333B0@2|Bacteria,1N983@1224|Proteobacteria,1SDQM@1236|Gammaproteobacteria,2PP2Y@256005|Alteromonadales genera incertae sedis	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6696659_0	1123053.AUDG01000022_gene579	0.0	1109.0	COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,1RNCU@1236|Gammaproteobacteria,1WWJQ@135613|Chromatiales	135613|Chromatiales	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
HKD2_k127_6696659_32	1122135.KB893135_gene930	2.97e-16	89.0	COG2199@1|root,COG3706@2|Bacteria,1P2K6@1224|Proteobacteria,2TRAJ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
HKD2_k127_6696659_8	395493.BegalDRAFT_3022	7.158e-107	359.0	COG1472@1|root,COG1472@2|Bacteria,1MVAJ@1224|Proteobacteria,1RMQF@1236|Gammaproteobacteria,45ZWB@72273|Thiotrichales	72273|Thiotrichales	G	Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides	nagZ	-	3.2.1.52	ko:K01207	ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501	M00628	R00022,R05963,R07809,R07810,R10831	RC00049	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyco_hydro_3
HKD2_k127_6696659_23	686340.Metal_3284	4.964e-48	177.0	COG2954@1|root,COG2954@2|Bacteria,1RI38@1224|Proteobacteria,1S77V@1236|Gammaproteobacteria,1XF52@135618|Methylococcales	135618|Methylococcales	S	CYTH	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	CYTH
HKD2_k127_6696659_3	396588.Tgr7_1102	1.027e-141	464.0	COG2265@1|root,COG2265@2|Bacteria,1MV3A@1224|Proteobacteria,1RN1D@1236|Gammaproteobacteria,1WWDA@135613|Chromatiales	135613|Chromatiales	J	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA	rlmD	-	2.1.1.190	ko:K03215	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TRAM,tRNA_U5-meth_tr
HKD2_k127_6696659_10	713586.KB900536_gene166	9.404e-102	340.0	COG3298@1|root,COG3298@2|Bacteria,1MVZJ@1224|Proteobacteria,1S4HU@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	3'-5' exonuclease related to the exonuclease domain of PolB	-	-	-	ko:K07501	-	-	-	-	ko00000	-	-	-	DNA_pol_B_exo2
HKD2_k127_6696659_30	42565.FP66_08030	1.16e-25	110.0	COG0736@1|root,COG0736@2|Bacteria,1MZBF@1224|Proteobacteria,1S98P@1236|Gammaproteobacteria,1XKU7@135619|Oceanospirillales	135619|Oceanospirillales	I	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein	acpS	-	2.7.8.7	ko:K00997	ko00770,map00770	-	R01625	RC00002	ko00000,ko00001,ko01000	-	-	-	ACPS
HKD2_k127_6696659_13	187272.Mlg_1350	1.467e-93	312.0	COG0854@1|root,COG0854@2|Bacteria,1MU9W@1224|Proteobacteria,1RMS5@1236|Gammaproteobacteria,1WXFG@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate	pdxJ	-	2.6.99.2	ko:K03474	ko00750,ko01100,map00750,map01100	M00124	R05838	RC01476	ko00000,ko00001,ko00002,ko01000	-	-	-	PdxJ
HKD2_k127_6696659_25	580332.Slit_1284	2.203e-43	178.0	COG1381@1|root,COG1381@2|Bacteria,1RHIC@1224|Proteobacteria,2VJUC@28216|Betaproteobacteria,44V76@713636|Nitrosomonadales	28216|Betaproteobacteria	L	Involved in DNA repair and RecF pathway recombination	recO	-	-	ko:K03584	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecO_C,RecO_N
HKD2_k127_6696659_12	298386.PBPRA3088	7.347e-96	324.0	COG1159@1|root,COG1159@2|Bacteria,1MUKT@1224|Proteobacteria,1RN3A@1236|Gammaproteobacteria,1XUB4@135623|Vibrionales	135623|Vibrionales	S	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism	era	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0005488,GO:0005525,GO:0017076,GO:0019001,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K03595	-	-	-	-	ko00000,ko03009,ko03029	-	-	-	KH_2,MMR_HSR1
HKD2_k127_6696659_21	187272.Mlg_1347	1.843e-62	222.0	COG0571@1|root,COG0571@2|Bacteria,1MUQ6@1224|Proteobacteria,1RN0C@1236|Gammaproteobacteria,1WY7U@135613|Chromatiales	135613|Chromatiales	J	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism	rnc	-	3.1.26.3	ko:K03685	ko03008,ko05205,map03008,map05205	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019,ko03036	-	-	-	Ribonucleas_3_3,dsrm
HKD2_k127_6696659_33	1415779.JOMH01000001_gene2970	2.074e-11	73.0	2DNXQ@1|root,32ZPK@2|Bacteria,1NDS1@1224|Proteobacteria,1SE45@1236|Gammaproteobacteria,1X8FY@135614|Xanthomonadales	135614|Xanthomonadales	S	Domain of unknown function (DUF4845)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4845
HKD2_k127_6696659_28	765914.ThisiDRAFT_2308	3.521e-32	129.0	COG0681@1|root,COG0681@2|Bacteria,1MXUF@1224|Proteobacteria,1RMHI@1236|Gammaproteobacteria,1WXAU@135613|Chromatiales	135613|Chromatiales	U	Belongs to the peptidase S26 family	-	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24,Peptidase_S26
HKD2_k127_6774942_0	765913.ThidrDRAFT_3332	3.277e-258	806.0	COG0504@1|root,COG0504@2|Bacteria,1MUIT@1224|Proteobacteria,1RM92@1236|Gammaproteobacteria,1WWJ8@135613|Chromatiales	135613|Chromatiales	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_synth_N,GATase
HKD2_k127_6774942_2	935863.AWZR01000005_gene2217	9.117e-127	436.0	COG2877@1|root,COG2877@2|Bacteria,1MV91@1224|Proteobacteria,1RMGQ@1236|Gammaproteobacteria,1X45V@135614|Xanthomonadales	135614|Xanthomonadales	M	Belongs to the KdsA family	kdsA	-	2.5.1.55	ko:K01627	ko00540,ko01100,map00540,map01100	M00063	R03254	RC00435	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	DAHP_synth_1
HKD2_k127_6774942_1	1122603.ATVI01000005_gene3187	8.715e-153	503.0	COG0148@1|root,COG0148@2|Bacteria,1MU1N@1224|Proteobacteria,1RNQA@1236|Gammaproteobacteria,1X2YM@135614|Xanthomonadales	135614|Xanthomonadales	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
HKD2_k127_6775432_11	1121015.N789_01360	1.58e-72	250.0	COG1354@1|root,COG1354@2|Bacteria,1MVCN@1224|Proteobacteria,1RNBB@1236|Gammaproteobacteria,1X315@135614|Xanthomonadales	135614|Xanthomonadales	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves	scpA	-	-	ko:K05896	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpA
HKD2_k127_6775432_13	2340.JV46_18830	1.112e-67	238.0	COG1386@1|root,COG1386@2|Bacteria,1PUA6@1224|Proteobacteria,1RNXE@1236|Gammaproteobacteria,1J5NC@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves	scpB	-	-	ko:K06024	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpB
HKD2_k127_6775432_14	1121035.AUCH01000021_gene2717	1.104e-50	190.0	COG1187@1|root,COG1187@2|Bacteria,1MUCE@1224|Proteobacteria,2VITB@28216|Betaproteobacteria,2KUDH@206389|Rhodocyclales	206389|Rhodocyclales	J	Belongs to the pseudouridine synthase RsuA family	-	-	5.4.99.22	ko:K06178	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
HKD2_k127_6775432_9	1279017.AQYJ01000026_gene200	9.122e-79	272.0	COG1028@1|root,COG1028@2|Bacteria,1MWBC@1224|Proteobacteria,1RNNV@1236|Gammaproteobacteria,46407@72275|Alteromonadaceae	1236|Gammaproteobacteria	IQ	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	yciK	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0008150,GO:0008152,GO:0009056,GO:0016491,GO:0044464,GO:0055114,GO:0071704,GO:1901575	-	-	-	-	-	-	-	-	-	-	adh_short
HKD2_k127_6775432_15	1123392.AQWL01000008_gene1185	5.088e-31	136.0	COG1562@1|root,COG1562@2|Bacteria,1MX4W@1224|Proteobacteria,2VJ13@28216|Betaproteobacteria,1KS8G@119069|Hydrogenophilales	119069|Hydrogenophilales	I	Squalene/phytoene synthase	-	-	2.5.1.32,2.5.1.99	ko:K02291	ko00906,ko01062,ko01100,ko01110,map00906,map01062,map01100,map01110	M00097	R02065,R04218,R07270,R10177	RC00362,RC01101,RC02869	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	SQS_PSY
HKD2_k127_6775432_7	713586.KB900536_gene582	5.117e-125	419.0	COG1322@1|root,COG1322@2|Bacteria,1MWHV@1224|Proteobacteria,1RMB8@1236|Gammaproteobacteria,1WYRX@135613|Chromatiales	135613|Chromatiales	S	RmuC family	-	-	-	ko:K09760	-	-	-	-	ko00000	-	-	-	RmuC
HKD2_k127_6775432_12	713586.KB900536_gene583	1.954e-68	246.0	COG0546@1|root,COG0546@2|Bacteria,1RCXJ@1224|Proteobacteria,1S3VU@1236|Gammaproteobacteria,1WXXM@135613|Chromatiales	135613|Chromatiales	S	HAD-superfamily hydrolase, subfamily IA, variant 1	-	-	3.1.3.105	ko:K22292	ko00520,map00520	-	R11785	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
HKD2_k127_6775432_8	1112217.PPL19_10532	2.479e-90	302.0	COG2227@1|root,COG2227@2|Bacteria,1MU89@1224|Proteobacteria,1RMV7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway	ubiG	GO:0003674,GO:0003824,GO:0005488,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0006950,GO:0006970,GO:0006972,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008289,GO:0008689,GO:0008757,GO:0009058,GO:0009108,GO:0009628,GO:0009651,GO:0009987,GO:0016740,GO:0016741,GO:0032259,GO:0042180,GO:0042181,GO:0042538,GO:0043167,GO:0043168,GO:0043431,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051186,GO:0051188,GO:0061542,GO:0071704,GO:1901576,GO:1901611,GO:1901661,GO:1901663	2.1.1.222,2.1.1.64	ko:K00568	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04988,R05614,R08769,R08781	RC00003,RC00392,RC01895	ko00000,ko00001,ko00002,ko01000	-	-	iE2348C_1286.E2348C_2376	Methyltransf_23
HKD2_k127_6775432_5	396588.Tgr7_1531	7.774e-151	492.0	COG0402@1|root,COG0402@2|Bacteria,1MVPA@1224|Proteobacteria,1RN13@1236|Gammaproteobacteria,1WWJ0@135613|Chromatiales	135613|Chromatiales	F	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine	mtaD	-	3.5.4.28,3.5.4.31	ko:K12960	ko00270,ko01100,map00270,map01100	-	R09660	RC00477	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
HKD2_k127_6775432_0	396588.Tgr7_1535	0.0	1245.0	COG0188@1|root,COG0188@2|Bacteria,1MUGG@1224|Proteobacteria,1RN03@1236|Gammaproteobacteria,1WXK8@135613|Chromatiales	135613|Chromatiales	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
HKD2_k127_6775432_3	187272.Mlg_0924	4.176e-159	509.0	COG1932@1|root,COG1932@2|Bacteria,1MUB5@1224|Proteobacteria,1RMKU@1236|Gammaproteobacteria,1WWHV@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine	serC	-	2.6.1.52	ko:K00831	ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230	M00020,M00124	R04173,R05085	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_5
HKD2_k127_6775432_2	1123261.AXDW01000001_gene1068	5.208e-169	538.0	COG0111@1|root,COG0111@2|Bacteria,1MU5Z@1224|Proteobacteria,1RPEY@1236|Gammaproteobacteria,1X4WZ@135614|Xanthomonadales	135614|Xanthomonadales	EH	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family	-	-	-	-	-	-	-	-	-	-	-	-	2-Hacid_dh,2-Hacid_dh_C,ACT
HKD2_k127_6775432_6	1121015.N789_00165	1.504e-125	439.0	COG0077@1|root,COG1605@1|root,COG0077@2|Bacteria,COG1605@2|Bacteria,1MU60@1224|Proteobacteria,1RNRD@1236|Gammaproteobacteria,1X4R7@135614|Xanthomonadales	135614|Xanthomonadales	E	Prephenate dehydratase	pheA	-	4.2.1.51,5.4.99.5	ko:K14170	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024,M00025	R00691,R01373,R01715	RC00360,RC03116	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,CM_2,PDT
HKD2_k127_6775432_4	519989.ECTPHS_08261	3.9e-158	516.0	COG0128@1|root,COG0128@2|Bacteria,1MWMK@1224|Proteobacteria,1RQ8U@1236|Gammaproteobacteria,1WX54@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	-	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	EPSP_synthase
HKD2_k127_6775432_10	187272.Mlg_0930	1.366e-74	261.0	COG0283@1|root,COG0283@2|Bacteria,1MUUD@1224|Proteobacteria,1RNKT@1236|Gammaproteobacteria,1WXNU@135613|Chromatiales	135613|Chromatiales	F	Belongs to the cytidylate kinase family. Type 1 subfamily	cmk	-	2.7.4.25	ko:K00945	ko00240,ko01100,map00240,map01100	M00052	R00158,R00512,R01665	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytidylate_kin
HKD2_k127_6775432_1	713586.KB900536_gene484	7.304e-270	842.0	COG0539@1|root,COG0539@2|Bacteria,1MVAV@1224|Proteobacteria,1RMFY@1236|Gammaproteobacteria,1WVVK@135613|Chromatiales	135613|Chromatiales	J	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence	rpsA	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
HKD2_k127_6825584_2	713586.KB900536_gene3031	4.102e-156	499.0	COG0443@1|root,COG0443@2|Bacteria,1MVEN@1224|Proteobacteria,1RMDD@1236|Gammaproteobacteria,1WVW2@135613|Chromatiales	135613|Chromatiales	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
HKD2_k127_6825584_1	1123279.ATUS01000001_gene1976	5.211e-158	507.0	COG0484@1|root,COG0484@2|Bacteria,1MVMS@1224|Proteobacteria,1RNHY@1236|Gammaproteobacteria,1J4DE@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	GO:0006457,GO:0008150,GO:0009987	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
HKD2_k127_6825584_4	292415.Tbd_1125	3.547e-79	272.0	COG0289@1|root,COG0289@2|Bacteria,1MUCT@1224|Proteobacteria,2VJC3@28216|Betaproteobacteria,1KS1U@119069|Hydrogenophilales	119069|Hydrogenophilales	E	Dihydrodipicolinate reductase, C-terminus	-	-	1.17.1.8	ko:K00215	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R04198,R04199	RC00478	ko00000,ko00001,ko00002,ko01000	-	-	-	DapB_C,DapB_N
HKD2_k127_6825584_0	396588.Tgr7_0975	2.217e-173	550.0	COG0505@1|root,COG0505@2|Bacteria,1MUB9@1224|Proteobacteria,1RMAW@1236|Gammaproteobacteria,1WXI6@135613|Chromatiales	135613|Chromatiales	F	Belongs to the CarA family	carA	-	6.3.5.5	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_sm_chain,GATase
HKD2_k127_6825584_3	2340.JV46_05960	4.304e-134	435.0	COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,1RPIU@1236|Gammaproteobacteria,1J5E8@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	F	Carbamoyl-phosphate synthetase ammonia chain	carB	GO:0000050,GO:0000166,GO:0003674,GO:0003824,GO:0004087,GO:0004088,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005951,GO:0006082,GO:0006139,GO:0006206,GO:0006220,GO:0006221,GO:0006520,GO:0006525,GO:0006526,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016053,GO:0016597,GO:0016874,GO:0016879,GO:0016884,GO:0017076,GO:0018130,GO:0019438,GO:0019627,GO:0019637,GO:0019693,GO:0019752,GO:0019856,GO:0030554,GO:0031406,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046390,GO:0046394,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0071941,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	iAF1260.b0033,iBWG_1329.BWG_0031,iECDH10B_1368.ECDH10B_0034,iECDH1ME8569_1439.ECDH1ME8569_0031,iECUMN_1333.ECUMN_0034,iEcDH1_1363.EcDH1_3566,iJN746.PP_4723,iJO1366.b0033,iJR904.b0033,iPC815.YPO0482,iY75_1357.Y75_RS00170,iYL1228.KPN_00041	CPSase_L_D2,CPSase_L_D3,MGS
HKD2_k127_6833514_8	1210884.HG799463_gene9989	7.624e-41	158.0	COG1595@1|root,COG1595@2|Bacteria,2IZXS@203682|Planctomycetes	203682|Planctomycetes	K	Sigma-70, region 4	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
HKD2_k127_6833514_10	397945.Aave_1160	6.797e-14	76.0	COG1918@1|root,COG1918@2|Bacteria,1NASN@1224|Proteobacteria,2VVSY@28216|Betaproteobacteria,4AFGG@80864|Comamonadaceae	28216|Betaproteobacteria	P	PFAM FeoA family protein	-	-	-	ko:K04758	-	-	-	-	ko00000,ko02000	-	-	-	FeoA
HKD2_k127_6833514_0	522306.CAP2UW1_0420	2.338e-255	801.0	COG0370@1|root,COG0370@2|Bacteria,1MUZC@1224|Proteobacteria,2VIRG@28216|Betaproteobacteria,1KQ88@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	P	Ferrous iron transport protein B C terminus	feoB	-	-	ko:K04759	-	-	-	-	ko00000,ko02000	9.A.8.1	-	-	FeoB_C,FeoB_N,Gate
HKD2_k127_6833514_3	452637.Oter_2603	1.419e-149	499.0	COG2864@1|root,COG2864@2|Bacteria	2|Bacteria	C	formate dehydrogenase	cbcY	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_c3_2,Cytochrome_C7,Ni_hydr_CYTB,Paired_CXXCH_1,Rhodanese
HKD2_k127_6833514_4	290397.Adeh_1659	4.165e-141	464.0	COG3005@1|root,COG3005@2|Bacteria,1R956@1224|Proteobacteria,42Q0X@68525|delta/epsilon subdivisions,2WMHI@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	NapC/NirT cytochrome c family, N-terminal region	-	GO:0003674,GO:0003824,GO:0005575,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0022900,GO:0031224,GO:0044237,GO:0044425,GO:0045333,GO:0055114	-	-	-	-	-	-	-	-	-	-	Cytochrom_NNT
HKD2_k127_6833514_11	1211114.ALIP01000164_gene2778	2.136e-05	52.0	COG2863@1|root,COG2863@2|Bacteria,1N7W9@1224|Proteobacteria,1S90Z@1236|Gammaproteobacteria,1X787@135614|Xanthomonadales	135614|Xanthomonadales	C	cytochrome	cycM	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,Cytochrome_CBB3
HKD2_k127_6833514_2	1379698.RBG1_1C00001G0297	1.113e-149	496.0	COG4881@1|root,COG4881@2|Bacteria	2|Bacteria	-	-	cbcU	-	-	-	-	-	-	-	-	-	-	-	NrfD
HKD2_k127_6833514_5	1379698.RBG1_1C00001G0296	1.875e-99	332.0	COG0437@1|root,COG0437@2|Bacteria,2NR78@2323|unclassified Bacteria	2|Bacteria	C	4Fe-4S binding domain	ttrB	-	-	ko:K08358	ko00920,ko01120,ko02020,map00920,map01120,map02020	-	R10150	RC03109	ko00000,ko00001,ko02000	5.A.3.10	-	-	Fer4_11,Fer4_3,Fer4_7
HKD2_k127_6833514_7	1379698.RBG1_1C00001G0295	9.923e-71	247.0	COG3303@1|root,COG3303@2|Bacteria	2|Bacteria	C	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process	-	-	-	ko:K04013,ko:K15876	ko00910,ko01120,map00910,map01120	M00530	R05712	RC00176	ko00000,ko00001,ko00002	-	-	-	Cytochrom_C552,Cytochrom_c3_2,Cytochrome_C554,Paired_CXXCH_1
HKD2_k127_6833514_6	404589.Anae109_3084	1.99e-88	314.0	2C6TZ@1|root,32RHS@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6833514_1	640081.Dsui_1883	2.062e-196	631.0	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,2VH4J@28216|Betaproteobacteria,2KUGP@206389|Rhodocyclales	206389|Rhodocyclales	S	ABC transporter	abcZ	-	-	ko:K15738	-	-	-	-	ko00000,ko02000	3.A.1.120.6	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
HKD2_k127_6833514_9	1408310.JHUW01000007_gene357	1.529e-16	83.0	2C1YS@1|root,2ZD2Y@2|Bacteria	2|Bacteria	S	Protease prsW family	-	-	-	-	-	-	-	-	-	-	-	-	PrsW-protease
HKD2_k127_6839674_0	1090318.ATTI01000001_gene2231	5.098e-161	532.0	COG0308@1|root,COG0308@2|Bacteria,1MUCI@1224|Proteobacteria,2U39Z@28211|Alphaproteobacteria,2KD1X@204457|Sphingomonadales	204457|Sphingomonadales	E	ERAP1-like C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	ERAP1_C,Peptidase_M1
HKD2_k127_6861056_6	1385517.N800_06325	2.16e-90	316.0	COG1807@1|root,COG1807@2|Bacteria,1NMIZ@1224|Proteobacteria,1RMA2@1236|Gammaproteobacteria,1X3KI@135614|Xanthomonadales	135614|Xanthomonadales	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT,PMT_2
HKD2_k127_6861056_2	1121015.N789_08290	8.35e-173	559.0	COG4579@1|root,COG4579@2|Bacteria,1MVRB@1224|Proteobacteria,1RMC2@1236|Gammaproteobacteria,1X3M4@135614|Xanthomonadales	135614|Xanthomonadales	F	Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation	aceK	GO:0000166,GO:0003674,GO:0003824,GO:0004672,GO:0004721,GO:0005488,GO:0005524,GO:0006464,GO:0006468,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008772,GO:0009987,GO:0016208,GO:0016301,GO:0016310,GO:0016311,GO:0016740,GO:0016772,GO:0016773,GO:0016787,GO:0016788,GO:0016791,GO:0017076,GO:0018105,GO:0018193,GO:0018209,GO:0019538,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0036211,GO:0042578,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0050790,GO:0065007,GO:0065009,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564	2.7.11.5	ko:K00906	-	-	-	-	ko00000,ko01000	-	-	-	AceK
HKD2_k127_6861056_1	1116472.MGMO_37c00150	6.273e-223	698.0	COG0538@1|root,COG0538@2|Bacteria,1MW3J@1224|Proteobacteria,1RNMD@1236|Gammaproteobacteria,1XEUJ@135618|Methylococcales	135618|Methylococcales	C	Isocitrate dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Iso_dh
HKD2_k127_6861056_10	1230343.CANP01000044_gene3405	1.256e-59	224.0	COG1538@1|root,COG1538@2|Bacteria,1NW1T@1224|Proteobacteria,1RPGN@1236|Gammaproteobacteria,1JCRN@118969|Legionellales	118969|Legionellales	MU	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
HKD2_k127_6861056_7	1161401.ASJA01000002_gene2626	3.829e-90	312.0	COG0845@1|root,COG5569@1|root,COG0845@2|Bacteria,COG5569@2|Bacteria,1MVAS@1224|Proteobacteria,2TTGG@28211|Alphaproteobacteria,43WVF@69657|Hyphomonadaceae	28211|Alphaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	cusB	-	-	ko:K07798	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4,8.A.1	-	-	CusF_Ec,HlyD_D23,HlyD_D4
HKD2_k127_6861056_0	653733.Selin_0035	0.0	1354.0	COG3696@1|root,COG3696@2|Bacteria	2|Bacteria	P	silver ion transport	cusA	-	-	ko:K07787	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4	-	iAF987.Gmet_1547	ACR_tran
HKD2_k127_6861056_3	402881.Plav_1144	6.987e-171	543.0	COG2957@1|root,COG2957@2|Bacteria,1MX65@1224|Proteobacteria,2U0RR@28211|Alphaproteobacteria,1JQ16@119043|Rhodobiaceae	28211|Alphaproteobacteria	E	Porphyromonas-type peptidyl-arginine deiminase	aguA	-	3.5.3.12	ko:K10536	ko00330,ko01100,map00330,map01100	-	R01416	RC00177	ko00000,ko00001,ko01000	-	-	-	PAD_porph
HKD2_k127_6861056_5	1123073.KB899241_gene2140	1.586e-94	322.0	COG0189@1|root,COG0189@2|Bacteria,1MV29@1224|Proteobacteria,1SB70@1236|Gammaproteobacteria,1X81A@135614|Xanthomonadales	135614|Xanthomonadales	HJ	COG0189 Glutathione synthase Ribosomal protein S6 modification enzyme (glutaminyl transferase)	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6861056_4	1049564.TevJSym_aj00110	3.741e-136	447.0	COG2831@1|root,COG2831@2|Bacteria,1QW38@1224|Proteobacteria,1T2R4@1236|Gammaproteobacteria,1J75U@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	U	Protein of unknown function (DUF3570)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3570
HKD2_k127_6861056_13	203122.Sde_3552	1.753e-18	94.0	2E3QA@1|root,32YN8@2|Bacteria,1N98P@1224|Proteobacteria,1SCNQ@1236|Gammaproteobacteria,468BH@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Domain of unknown function (DUF4266)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4266
HKD2_k127_6861056_11	1453501.JELR01000002_gene1339	1.086e-49	182.0	COG0526@1|root,COG0526@2|Bacteria,1MZ36@1224|Proteobacteria,1S8UU@1236|Gammaproteobacteria,4677J@72275|Alteromonadaceae	1236|Gammaproteobacteria	CO	Thioredoxin-like	resA	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,Redoxin
HKD2_k127_6861056_9	1049564.TevJSym_aj00080	6.475e-62	226.0	COG3637@1|root,COG3637@2|Bacteria,1RDPZ@1224|Proteobacteria,1S4GQ@1236|Gammaproteobacteria,1JADW@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety	-	-	-	-	-	-	-	-	-	-	-	-	OMP_b-brl
HKD2_k127_6861056_8	1121935.AQXX01000098_gene1656	1.41e-62	229.0	COG3807@1|root,COG3807@2|Bacteria,1RE8W@1224|Proteobacteria,1S4BU@1236|Gammaproteobacteria,1XPIQ@135619|Oceanospirillales	135619|Oceanospirillales	S	COG3103 SH3 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	OMP_b-brl,SH3_3,SH3_4
HKD2_k127_6861056_12	225937.HP15_2147	1.436e-30	124.0	COG0823@1|root,COG0823@2|Bacteria,1R3VN@1224|Proteobacteria,1RNKG@1236|Gammaproteobacteria,46408@72275|Alteromonadaceae	1236|Gammaproteobacteria	U	COG0823 Periplasmic component of the Tol biopolymer transport system	-	-	-	-	-	-	-	-	-	-	-	-	PD40
HKD2_k127_6876280_32	1234364.AMSF01000015_gene3186	2.584e-20	98.0	COG2902@1|root,COG2902@2|Bacteria,1MXNV@1224|Proteobacteria,1RQVZ@1236|Gammaproteobacteria,1X46R@135614|Xanthomonadales	135614|Xanthomonadales	E	glutamate dehydrogenase	-	-	1.4.1.2	ko:K15371	ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100	-	R00243	RC00006,RC02799	ko00000,ko00001,ko01000	-	-	-	Bac_GDH,GDH_N
HKD2_k127_6876280_26	641149.HMPREF9016_00616	1.089e-61	230.0	COG1215@1|root,COG1216@1|root,COG1215@2|Bacteria,COG1216@2|Bacteria,1QU2Q@1224|Proteobacteria,2WGZN@28216|Betaproteobacteria,2KQUV@206351|Neisseriales	206351|Neisseriales	M	Glycosyltransferase, group 2 family protein	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_7C,Glycos_transf_2
HKD2_k127_6876280_15	575540.Isop_1724	1.091e-113	371.0	COG0588@1|root,COG0588@2|Bacteria	2|Bacteria	G	phosphoglycerate mutase activity	gpmA	GO:0003674,GO:0003824,GO:0004619,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006109,GO:0006139,GO:0006140,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009894,GO:0009987,GO:0010675,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0018130,GO:0019219,GO:0019220,GO:0019222,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0031323,GO:0031329,GO:0032787,GO:0034248,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0043455,GO:0043456,GO:0043470,GO:0043471,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046538,GO:0046700,GO:0046939,GO:0050789,GO:0050794,GO:0051171,GO:0051174,GO:0051186,GO:0051188,GO:0051193,GO:0051196,GO:0055086,GO:0060255,GO:0062012,GO:0065007,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0080090,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1902031	5.4.2.11	ko:K01834	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	His_Phos_1
HKD2_k127_6876280_22	1218076.BAYB01000027_gene4488	5.509e-85	297.0	COG3791@1|root,COG3791@2|Bacteria,1RFBP@1224|Proteobacteria,2VQN8@28216|Betaproteobacteria,1K88K@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Glutathione-dependent formaldehyde-activating enzyme	-	-	-	-	-	-	-	-	-	-	-	-	GFA
HKD2_k127_6876280_17	876044.IMCC3088_1743	3.173e-100	335.0	COG1028@1|root,COG1028@2|Bacteria,1MW9A@1224|Proteobacteria,1RMC9@1236|Gammaproteobacteria	1236|Gammaproteobacteria	IQ	Dehydrogenases with different specificities (Related to short-chain alcohol dehydrogenases)	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HKD2_k127_6876280_10	1333998.M2A_1578	3.599e-136	444.0	COG2070@1|root,COG2070@2|Bacteria,1MU0U@1224|Proteobacteria,2TS5U@28211|Alphaproteobacteria,4BR6T@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Nitronate monooxygenase	MA20_20575	-	1.13.12.16	ko:K00459	ko00910,map00910	-	R00025	RC02541,RC02759	ko00000,ko00001,ko01000	-	-	-	NMO
HKD2_k127_6876280_1	1123261.AXDW01000033_gene2110	1.162e-274	862.0	COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,1RMZ8@1236|Gammaproteobacteria,1X4U6@135614|Xanthomonadales	135614|Xanthomonadales	I	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	3HCDH,3HCDH_N,ECH_1
HKD2_k127_6876280_5	414684.RC1_1744	1.827e-176	562.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2TQQ7@28211|Alphaproteobacteria,2JQCM@204441|Rhodospirillales	204441|Rhodospirillales	I	Belongs to the thiolase family	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
HKD2_k127_6876280_25	649747.HMPREF0083_05611	1.718e-66	238.0	COG1024@1|root,COG1024@2|Bacteria,1TQ2V@1239|Firmicutes,4HTKK@91061|Bacilli,276IV@186822|Paenibacillaceae	91061|Bacilli	I	Enoyl-CoA hydratase/isomerase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
HKD2_k127_6876280_28	247634.GPB2148_3081	3.965e-41	160.0	COG1309@1|root,COG1309@2|Bacteria,1RAF9@1224|Proteobacteria,1SHKH@1236|Gammaproteobacteria,1JAII@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
HKD2_k127_6876280_23	269799.Gmet_2217	9.677e-80	274.0	COG1028@1|root,COG1028@2|Bacteria,1MVQW@1224|Proteobacteria,42ZR2@68525|delta/epsilon subdivisions,2WV3H@28221|Deltaproteobacteria,43V3V@69541|Desulfuromonadales	28221|Deltaproteobacteria	IQ	KR domain	-	-	1.1.1.51	ko:K05296	ko00140,ko00984,ko01100,ko01120,map00140,map00984,map01100,map01120	-	R01836,R01838,R02352,R02353,R03406,R03407,R09956,R09957	RC00127,RC00144	ko00000,ko00001,ko01000	-	-	-	adh_short_C2
HKD2_k127_6876280_31	34007.IT40_16315	9.198e-26	109.0	COG0633@1|root,COG0633@2|Bacteria,1N261@1224|Proteobacteria,2UC7B@28211|Alphaproteobacteria,2PYTW@265|Paracoccus	28211|Alphaproteobacteria	C	2Fe-2S iron-sulfur cluster binding domain	-	-	-	ko:K04755	-	-	-	-	ko00000	-	-	-	Fer2
HKD2_k127_6876280_20	34007.IT40_16270	2.125e-88	299.0	COG1028@1|root,COG1028@2|Bacteria,1MW46@1224|Proteobacteria,2TUTU@28211|Alphaproteobacteria,2PY7J@265|Paracoccus	28211|Alphaproteobacteria	IQ	KR domain	MA20_15935	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HKD2_k127_6876280_21	247634.GPB2148_3089	2.315e-86	292.0	COG3828@1|root,COG3828@2|Bacteria,1QWCA@1224|Proteobacteria,1SGQU@1236|Gammaproteobacteria,1J9Y1@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	ThuA
HKD2_k127_6876280_2	392499.Swit_2271	5.69e-212	668.0	COG4638@1|root,COG4638@2|Bacteria,1MXZN@1224|Proteobacteria,2U2X0@28211|Alphaproteobacteria,2KCF5@204457|Sphingomonadales	204457|Sphingomonadales	P	Ring hydroxylating alpha subunit (catalytic domain)	-	-	-	-	-	-	-	-	-	-	-	-	Rieske,Ring_hydroxyl_A
HKD2_k127_6876280_12	1114959.SZMC14600_12655	4.347e-131	436.0	COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria,4EEJV@85010|Pseudonocardiales	201174|Actinobacteria	IQ	AMP-binding enzyme C-terminal domain	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
HKD2_k127_6876280_14	247634.GPB2148_3309	1.096e-127	416.0	COG1071@1|root,COG1071@2|Bacteria,1MU5R@1224|Proteobacteria,1RWHU@1236|Gammaproteobacteria,1J80G@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Dehydrogenase E1 component	acoA	-	-	ko:K21416	-	-	-	-	ko00000,ko01000	-	-	-	E1_dh
HKD2_k127_6876280_9	34007.IT40_16370	1.123e-146	471.0	COG0022@1|root,COG0022@2|Bacteria,1R8KB@1224|Proteobacteria,2TRFK@28211|Alphaproteobacteria,2PY72@265|Paracoccus	28211|Alphaproteobacteria	C	Transketolase, C-terminal domain	-	-	-	ko:K21417	-	-	-	-	ko00000,ko01000	-	-	-	Transket_pyr,Transketolase_C
HKD2_k127_6876280_30	1380394.JADL01000009_gene3148	1.538e-26	121.0	COG0510@1|root,COG0510@2|Bacteria,1MVBB@1224|Proteobacteria,2TT5Z@28211|Alphaproteobacteria,2JV0H@204441|Rhodospirillales	204441|Rhodospirillales	M	Choline/ethanolamine kinase	-	-	-	-	-	-	-	-	-	-	-	-	Choline_kinase
HKD2_k127_6876280_27	1122134.KB893650_gene1698	8.243e-47	179.0	COG3201@1|root,COG3201@2|Bacteria,1MXN4@1224|Proteobacteria,1RMZE@1236|Gammaproteobacteria,1XMGI@135619|Oceanospirillales	135619|Oceanospirillales	H	Nicotinamide mononucleotide transporter	-	-	-	ko:K03811	-	-	-	-	ko00000,ko02000	4.B.1.1	-	-	NMN_transporter
HKD2_k127_6876280_36	1286106.MPL1_09370	3.192e-14	83.0	COG0011@1|root,COG0011@2|Bacteria,1N8R0@1224|Proteobacteria,1SCF3@1236|Gammaproteobacteria,46157@72273|Thiotrichales	72273|Thiotrichales	S	YKOF-related Family	-	-	-	-	-	-	-	-	-	-	-	-	Ykof
HKD2_k127_6876280_6	1515746.HR45_04890	8.183e-172	562.0	COG4773@1|root,COG4773@2|Bacteria,1QTXJ@1224|Proteobacteria,1T2NX@1236|Gammaproteobacteria,2Q91E@267890|Shewanellaceae	1236|Gammaproteobacteria	P	TonB-dependent receptor plug	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
HKD2_k127_6876280_24	1121334.KB911074_gene2517	9.574e-69	244.0	COG0384@1|root,COG0384@2|Bacteria,1TRAF@1239|Firmicutes,25D2F@186801|Clostridia,3WSFK@541000|Ruminococcaceae	186801|Clostridia	S	Phenazine biosynthesis-like protein	-	-	5.3.3.17	ko:K06998	ko00405,ko01130,ko02024,map00405,map01130,map02024	M00835	-	-	ko00000,ko00001,ko00002,ko01000	-	-	-	PhzC-PhzF
HKD2_k127_6876280_34	392499.Swit_2267	9.859e-19	94.0	COG1359@1|root,COG1359@2|Bacteria,1NZAF@1224|Proteobacteria,2USRM@28211|Alphaproteobacteria,2KAX9@204457|Sphingomonadales	204457|Sphingomonadales	S	Antibiotic biosynthesis monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	ABM
HKD2_k127_6876280_35	1220535.IMCC14465_09700	2.137e-15	81.0	COG1359@1|root,COG1359@2|Bacteria,1NAV0@1224|Proteobacteria,2UJ8F@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Antibiotic biosynthesis monooxygenase	-	-	5.3.1.32	ko:K11530	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000	-	-	-	ABM
HKD2_k127_6876280_33	247634.GPB2148_3294	3.696e-19	91.0	COG2146@1|root,COG2146@2|Bacteria,1N8PE@1224|Proteobacteria,1RXCG@1236|Gammaproteobacteria,1JBB2@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	Rieske-like [2Fe-2S] domain	-	-	-	-	-	-	-	-	-	-	-	-	Rieske
HKD2_k127_6876280_3	1397666.RS24_01522	1.046e-187	595.0	COG1960@1|root,COG1960@2|Bacteria,1MX17@1224|Proteobacteria,2TTRE@28211|Alphaproteobacteria,4BRHN@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	ko:K18244	-	-	-	-	ko00000,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HKD2_k127_6876280_13	1038866.KB902824_gene1251	3.807e-130	432.0	COG1804@1|root,COG1804@2|Bacteria,1MVK4@1224|Proteobacteria,2TWRE@28211|Alphaproteobacteria,3JSRH@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	CoA-transferase family III	MA20_17775	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
HKD2_k127_6876280_19	97096.XP_007792810.1	1.174e-94	319.0	2CXVQ@1|root,2S039@2759|Eukaryota,39XRR@33154|Opisthokonta,3NWXS@4751|Fungi	4751|Fungi	O	glutathione s-transferase	-	-	-	-	-	-	-	-	-	-	-	-	GST_C_2,GST_N_3
HKD2_k127_6876280_8	158500.BV97_02847	3.374e-154	497.0	COG4638@1|root,COG4638@2|Bacteria,1MWXW@1224|Proteobacteria,2TSJ5@28211|Alphaproteobacteria,2K0FW@204457|Sphingomonadales	204457|Sphingomonadales	P	Ring hydroxylating alpha subunit (catalytic domain)	-	-	-	-	-	-	-	-	-	-	-	-	Rieske,Ring_hydroxyl_A
HKD2_k127_6876280_11	748247.AZKH_p0344	2.945e-132	439.0	COG1545@1|root,COG3425@1|root,COG1545@2|Bacteria,COG3425@2|Bacteria,1QV6D@1224|Proteobacteria,2VZG4@28216|Betaproteobacteria	28216|Betaproteobacteria	I	DUF35 OB-fold domain, acyl-CoA-associated	-	-	-	-	-	-	-	-	-	-	-	-	ACP_syn_III_C,DUF35_N,OB_aCoA_assoc
HKD2_k127_6876280_4	1397666.RS24_01526	1.594e-186	598.0	COG0183@1|root,COG0183@2|Bacteria,1MU8C@1224|Proteobacteria,2TS6P@28211|Alphaproteobacteria,4BP5Q@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	I	Thiolase, C-terminal domain	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
HKD2_k127_6876280_16	392499.Swit_2258	7.589e-110	368.0	COG1028@1|root,COG1028@2|Bacteria,1PFUB@1224|Proteobacteria,2U149@28211|Alphaproteobacteria,2K2UZ@204457|Sphingomonadales	204457|Sphingomonadales	IQ	KR domain	-	-	-	ko:K13774	ko00281,map00281	-	R08087,R08096,R10125,R10126	RC00080,RC00087	ko00000,ko00001	-	-	-	adh_short_C2
HKD2_k127_6876280_29	392499.Swit_1026	1.919e-36	152.0	COG2128@1|root,COG2128@2|Bacteria	2|Bacteria	S	hydroperoxide reductase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6876280_18	247639.MGP2080_02341	6.42e-95	325.0	COG0508@1|root,COG0508@2|Bacteria,1MUGY@1224|Proteobacteria,1RXY2@1236|Gammaproteobacteria,1J9U5@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	COG0508 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes	acoC	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
HKD2_k127_6876280_0	1265313.HRUBRA_01705	1.629e-308	968.0	COG1629@1|root,COG4771@2|Bacteria,1R5XT@1224|Proteobacteria	1224|Proteobacteria	P	COG1629 Outer membrane receptor proteins, mostly Fe transport	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
HKD2_k127_6876280_7	565045.NOR51B_335	5.763e-155	500.0	COG2124@1|root,COG2124@2|Bacteria,1MY5H@1224|Proteobacteria	1224|Proteobacteria	C	cytochrome p450	-	-	-	-	-	-	-	-	-	-	-	-	p450
HKD2_k127_6876280_37	1313172.YM304_06430	1.588e-06	60.0	2EHQJ@1|root,33BGC@2|Bacteria	2|Bacteria	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_4
HKD2_k127_6877850_1	614083.AWQR01000025_gene3719	3.467e-28	115.0	2DNSI@1|root,32YXC@2|Bacteria,1N7K2@1224|Proteobacteria,2VVXF@28216|Betaproteobacteria,4AFCE@80864|Comamonadaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6877850_2	1121405.dsmv_2300	1.617e-16	80.0	2EFZF@1|root,339RM@2|Bacteria,1NH6S@1224|Proteobacteria,42WYZ@68525|delta/epsilon subdivisions,2WT48@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6877850_0	292415.Tbd_0102	1.048e-53	198.0	COG3134@1|root,COG3134@2|Bacteria,1MVWD@1224|Proteobacteria	1224|Proteobacteria	S	Outer Membrane Lipoprotein	ycfJ	GO:0008150,GO:0043900,GO:0050789,GO:0050794,GO:0065007,GO:1900190	-	-	-	-	-	-	-	-	-	-	Rick_17kDa_Anti
HKD2_k127_690608_0	572477.Alvin_1100	0.0	1182.0	COG0013@1|root,COG0013@2|Bacteria,1MU9A@1224|Proteobacteria,1RMWZ@1236|Gammaproteobacteria,1WXPB@135613|Chromatiales	135613|Chromatiales	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
HKD2_k127_690608_3	349124.Hhal_1654	1.944e-27	121.0	COG2137@1|root,COG2137@2|Bacteria,1N6P6@1224|Proteobacteria,1SCMF@1236|Gammaproteobacteria,1WYJU@135613|Chromatiales	135613|Chromatiales	S	Modulates RecA activity	recX	-	-	ko:K03565	-	-	-	-	ko00000,ko03400	-	-	-	RecX
HKD2_k127_690608_1	754476.Q7A_1665	2.743e-164	534.0	COG0468@1|root,COG0468@2|Bacteria,1MU3C@1224|Proteobacteria,1RMHP@1236|Gammaproteobacteria,45ZTK@72273|Thiotrichales	72273|Thiotrichales	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage	recA	-	-	ko:K03553	ko03440,map03440	M00729	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	RecA
HKD2_k127_690608_2	1283300.ATXB01000001_gene309	1.525e-27	117.0	COG1514@1|root,COG1514@2|Bacteria,1RDB2@1224|Proteobacteria,1SCZX@1236|Gammaproteobacteria,1XFHW@135618|Methylococcales	135618|Methylococcales	J	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester	-	-	3.1.4.58	ko:K01975	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	LigT_PEase
HKD2_k127_6933224_0	595537.Varpa_2646	5.006e-215	676.0	COG0427@1|root,COG0427@2|Bacteria,1MUGE@1224|Proteobacteria,2VIF1@28216|Betaproteobacteria,4AD4G@80864|Comamonadaceae	28216|Betaproteobacteria	C	PFAM Acetyl-CoA hydrolase transferase	-	-	3.1.2.1	ko:K01067	ko00620,map00620	-	R00227	RC00004,RC00012	ko00000,ko00001,ko01000	-	-	-	AcetylCoA_hyd_C,AcetylCoA_hydro
HKD2_k127_6933224_1	62928.azo3211	1.263e-60	211.0	COG0280@1|root,COG0281@1|root,COG0280@2|Bacteria,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,2VIYB@28216|Betaproteobacteria,2KV7P@206389|Rhodocyclales	206389|Rhodocyclales	C	Malic enzyme	-	-	1.1.1.40	ko:K00029	ko00620,ko00710,ko01100,ko01120,ko01200,map00620,map00710,map01100,map01120,map01200	M00169,M00172	R00216	RC00105	ko00000,ko00001,ko00002,ko01000	-	-	-	Malic_M,PTA_PTB,malic
HKD2_k127_7054569_1	287.DR97_4945	2.654e-40	154.0	COG1477@1|root,COG1477@2|Bacteria,1MW6K@1224|Proteobacteria,1RNMZ@1236|Gammaproteobacteria,1YF71@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	H	Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein	apbE	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009897,GO:0009986,GO:0009987,GO:0016020,GO:0016740,GO:0017013,GO:0019538,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031233,GO:0031237,GO:0031975,GO:0036094,GO:0036211,GO:0042597,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0046872,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0071944,GO:0071949,GO:0097159,GO:0098552,GO:0098567,GO:1901265,GO:1901363,GO:1901564	2.7.1.180	ko:K03734	-	-	-	-	ko00000,ko01000	-	-	-	ApbE
HKD2_k127_7054569_3	215803.DB30_7076	5.434e-15	84.0	COG0406@1|root,COG0406@2|Bacteria,1N92W@1224|Proteobacteria,433TG@68525|delta/epsilon subdivisions,2X3E8@28221|Deltaproteobacteria,2YVPC@29|Myxococcales	28221|Deltaproteobacteria	G	Phosphoglycerate mutase family	-	-	-	-	-	-	-	-	-	-	-	-	His_Phos_1
HKD2_k127_7054569_2	575540.Isop_0033	9.142e-35	138.0	COG1225@1|root,COG1225@2|Bacteria,2IZIQ@203682|Planctomycetes	203682|Planctomycetes	O	PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	-	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
HKD2_k127_7054569_0	1123253.AUBD01000002_gene1329	3.266e-55	199.0	COG0454@1|root,COG0456@2|Bacteria,1RJ1K@1224|Proteobacteria,1S6RV@1236|Gammaproteobacteria,1X6U1@135614|Xanthomonadales	135614|Xanthomonadales	K	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HKD2_k127_711210_0	519989.ECTPHS_08493	1.938e-172	563.0	COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,1RMAP@1236|Gammaproteobacteria,1WXD9@135613|Chromatiales	135613|Chromatiales	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamA	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
HKD2_k127_711210_1	267608.RSc1413	1.047e-09	66.0	COG2825@1|root,COG2825@2|Bacteria,1RD8X@1224|Proteobacteria,2VRZI@28216|Betaproteobacteria,1K13G@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Belongs to the skp family	ompH	-	-	ko:K06142	-	-	-	-	ko00000	-	-	-	OmpH
HKD2_k127_7139424_5	1121015.N789_03840	1.627e-44	166.0	COG1664@1|root,COG1664@2|Bacteria,1MZG6@1224|Proteobacteria,1S826@1236|Gammaproteobacteria,1X74A@135614|Xanthomonadales	135614|Xanthomonadales	M	Integral membrane protein CcmA involved in cell shape determination	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
HKD2_k127_7139424_7	1121015.N789_03845	1.645e-33	132.0	2BH75@1|root,32B8F@2|Bacteria,1QB6K@1224|Proteobacteria,1T6QF@1236|Gammaproteobacteria,1X7EX@135614|Xanthomonadales	135614|Xanthomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7139424_10	1552758.NC00_03610	2.779e-09	62.0	2ANYG@1|root,31DZF@2|Bacteria,1QB9H@1224|Proteobacteria,1T6TX@1236|Gammaproteobacteria,1X857@135614|Xanthomonadales	135614|Xanthomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7139424_8	765914.ThisiDRAFT_0650	9.215e-26	117.0	COG0298@1|root,COG0298@2|Bacteria,1QKV6@1224|Proteobacteria,1SE6V@1236|Gammaproteobacteria,1WZDC@135613|Chromatiales	135613|Chromatiales	O	PFAM hydrogenase expression formation protein (HUPF HYPC)	-	-	-	ko:K04653	-	-	-	-	ko00000	-	-	-	HupF_HypC
HKD2_k127_7139424_6	396588.Tgr7_1273	7.99e-38	145.0	COG0375@1|root,COG0375@2|Bacteria,1MZJH@1224|Proteobacteria,1S5WG@1236|Gammaproteobacteria,1WYQN@135613|Chromatiales	135613|Chromatiales	S	Probably plays a role in a hydrogenase nickel cofactor insertion step	hypA	-	-	ko:K04651	-	-	-	-	ko00000,ko03110	-	-	-	HypA
HKD2_k127_7139424_4	396588.Tgr7_1274	7.373e-98	332.0	COG0378@1|root,COG0378@2|Bacteria,1MVBD@1224|Proteobacteria,1RN9Y@1236|Gammaproteobacteria,1WWGI@135613|Chromatiales	135613|Chromatiales	KO	TIGRFAM Hydrogenase accessory protein HypB	-	-	-	ko:K04652	-	-	-	-	ko00000,ko03110	-	-	-	cobW
HKD2_k127_7139424_1	2340.JV46_24290	8.458e-178	572.0	COG0409@1|root,COG0409@2|Bacteria,1MU1F@1224|Proteobacteria,1RRTQ@1236|Gammaproteobacteria,1J9VF@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	O	Hydrogenase formation hypA family	hypD	GO:0003674,GO:0005488,GO:0005506,GO:0006464,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0019538,GO:0036211,GO:0042165,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046872,GO:0046914,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0051604,GO:0070025,GO:0071704,GO:1901564	-	ko:K04654	-	-	-	-	ko00000	-	-	-	HypD
HKD2_k127_7139424_0	1123392.AQWL01000003_gene150	6.346e-257	815.0	COG0068@1|root,COG0068@2|Bacteria,1MVP8@1224|Proteobacteria,2VHS4@28216|Betaproteobacteria,1KSM8@119069|Hydrogenophilales	119069|Hydrogenophilales	O	HypF finger	-	-	-	-	-	-	-	-	-	-	-	-	Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF
HKD2_k127_7139424_3	56780.SYN_01802	3.128e-119	397.0	COG0635@1|root,COG0635@2|Bacteria,1MV1I@1224|Proteobacteria,42MN3@68525|delta/epsilon subdivisions,2WMHC@28221|Deltaproteobacteria,2MQVK@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
HKD2_k127_7139424_2	1123392.AQWL01000003_gene151	5.816e-131	445.0	COG0309@1|root,COG0309@2|Bacteria,1MVCC@1224|Proteobacteria,2VH3K@28216|Betaproteobacteria,1KSUP@119069|Hydrogenophilales	119069|Hydrogenophilales	O	AIR synthase related protein, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AIRS,AIRS_C
HKD2_k127_7139424_9	1410619.SRDD_34710	3.887e-24	106.0	COG3631@1|root,COG3631@2|Bacteria,1NIDX@1224|Proteobacteria,1SZRA@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_2
HKD2_k127_7172959_2	926569.ANT_06560	6.428e-39	163.0	COG1807@1|root,COG1807@2|Bacteria	2|Bacteria	M	4-amino-4-deoxy-L-arabinose transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	PMT,PMT_2
HKD2_k127_7172959_0	492774.JQMB01000005_gene5142	7.108e-146	486.0	COG1835@1|root,COG1835@2|Bacteria,1MV2W@1224|Proteobacteria,2TRT8@28211|Alphaproteobacteria,4B7WN@82115|Rhizobiaceae	28211|Alphaproteobacteria	I	Acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
HKD2_k127_7172959_1	84531.JMTZ01000100_gene1436	5.434e-51	193.0	2EBAQ@1|root,335BC@2|Bacteria,1RGPY@1224|Proteobacteria,1SFCC@1236|Gammaproteobacteria,1X6YV@135614|Xanthomonadales	135614|Xanthomonadales	S	Putative MetA-pathway of phenol degradation	-	-	-	-	-	-	-	-	-	-	-	-	Phenol_MetA_deg
HKD2_k127_7172959_3	452637.Oter_0383	9.591e-37	144.0	COG1301@1|root,COG1301@2|Bacteria,46U9C@74201|Verrucomicrobia,3K7YK@414999|Opitutae	414999|Opitutae	U	Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family	-	-	-	-	-	-	-	-	-	-	-	-	SDF
HKD2_k127_7293598_13	1121440.AUMA01000005_gene2750	7.224e-62	228.0	COG0501@1|root,COG0501@2|Bacteria,1RH15@1224|Proteobacteria,4336I@68525|delta/epsilon subdivisions,2WXXB@28221|Deltaproteobacteria,2MB3G@213115|Desulfovibrionales	28221|Deltaproteobacteria	O	SMART PDZ DHR GLGF domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Peptidase_M48
HKD2_k127_7293598_9	83406.HDN1F_29180	1.364e-93	316.0	COG0204@1|root,COG0204@2|Bacteria,1MVWG@1224|Proteobacteria,1RR21@1236|Gammaproteobacteria,1J8T5@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	I	COG0204 1-acyl-sn-glycerol-3-phosphate acyltransferase	yihG	-	-	-	-	-	-	-	-	-	-	-	Acyltransferase
HKD2_k127_7293598_11	1163617.SCD_n02730	4.564e-66	246.0	COG3132@1|root,COG3132@2|Bacteria,1RA13@1224|Proteobacteria,2VQGS@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Belongs to the UPF0502 family	yceH	-	-	ko:K09915	-	-	-	-	ko00000	-	-	-	DUF480
HKD2_k127_7293598_6	1380394.JADL01000011_gene4046	3.98e-127	418.0	COG1902@1|root,COG1902@2|Bacteria,1MVE0@1224|Proteobacteria,2TQPY@28211|Alphaproteobacteria,2JQUF@204441|Rhodospirillales	204441|Rhodospirillales	C	COG1902 NADH flavin oxidoreductases, Old Yellow Enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_FMN
HKD2_k127_7293598_17	497321.C664_06873	1.305e-34	138.0	COG3576@1|root,COG3576@2|Bacteria,1N8Z5@1224|Proteobacteria,2VVVW@28216|Betaproteobacteria,2KX6P@206389|Rhodocyclales	206389|Rhodocyclales	S	pyridoxamine 5-phosphate	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7293598_4	62928.azo1538	4.126e-151	502.0	COG2203@1|root,COG2203@2|Bacteria,1PP8V@1224|Proteobacteria,2VKHH@28216|Betaproteobacteria,2KXR2@206389|Rhodocyclales	206389|Rhodocyclales	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	GAF_2,Putative_PNPOx
HKD2_k127_7293598_15	1123392.AQWL01000002_gene1719	2.911e-48	179.0	COG2010@1|root,COG2010@2|Bacteria,1N0EF@1224|Proteobacteria,2VT6G@28216|Betaproteobacteria,1KT3M@119069|Hydrogenophilales	119069|Hydrogenophilales	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C
HKD2_k127_7293598_7	159087.Daro_1776	4.884e-115	376.0	COG0479@1|root,COG0479@2|Bacteria,1MVHS@1224|Proteobacteria,2VIKC@28216|Betaproteobacteria,2KY25@206389|Rhodocyclales	206389|Rhodocyclales	C	2Fe-2S iron-sulfur cluster binding domain	-	-	1.3.5.4	ko:K00245	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020	M00009,M00011,M00150,M00173	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_3,Fer4_8
HKD2_k127_7293598_0	765914.ThisiDRAFT_1964	4.2e-322	998.0	COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,1RMU2@1236|Gammaproteobacteria,1WW72@135613|Chromatiales	135613|Chromatiales	C	Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily	-	-	1.3.5.4	ko:K00244	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020	M00009,M00011,M00150,M00173	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
HKD2_k127_7293598_8	765914.ThisiDRAFT_1965	1.201e-94	317.0	COG2009@1|root,2ZBTX@2|Bacteria,1RB22@1224|Proteobacteria,1S4JK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	fumarate reductase respiratory complex transmembrane subunit	-	-	-	ko:K00246	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020	M00009,M00011,M00150,M00173	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	Sdh_cyt
HKD2_k127_7293598_16	1255043.TVNIR_1957	2.094e-46	170.0	COG0838@1|root,COG0838@2|Bacteria	2|Bacteria	C	NADH dehydrogenase (ubiquinone) activity	nuoA	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0044425,GO:0050136,GO:0055114,GO:0098796,GO:1902494	1.6.5.3	ko:K00330	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q4
HKD2_k127_7293598_10	1255043.TVNIR_1956	4.323e-92	311.0	COG0377@1|root,COG0377@2|Bacteria,1MUI2@1224|Proteobacteria,1RP4R@1236|Gammaproteobacteria,1WW6I@135613|Chromatiales	135613|Chromatiales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	-	1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q6
HKD2_k127_7293598_14	713587.THITH_10375	1.73e-60	220.0	COG0852@1|root,COG0852@2|Bacteria	2|Bacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoC	GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564	1.6.5.3	ko:K00332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	iAF987.Gmet_3353	Complex1_30kDa
HKD2_k127_7293598_1	1255043.TVNIR_1954	2.724e-227	713.0	COG0649@1|root,COG0649@2|Bacteria,1MVIN@1224|Proteobacteria,1RM98@1236|Gammaproteobacteria,1WWN5@135613|Chromatiales	135613|Chromatiales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	-	1.6.5.3	ko:K00333	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa
HKD2_k127_7293598_12	713587.THITH_10365	3.245e-65	242.0	COG1905@1|root,COG1905@2|Bacteria,1MWS2@1224|Proteobacteria,1RN4C@1236|Gammaproteobacteria,1WWTG@135613|Chromatiales	135613|Chromatiales	C	TIGRFAM NADH-quinone oxidoreductase, E subunit	-	-	1.6.5.3	ko:K00334	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
HKD2_k127_7293598_3	379066.GAU_2398	4.802e-195	624.0	COG1894@1|root,COG1894@2|Bacteria,1ZUDU@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region	-	-	1.6.5.3	ko:K00335	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_51K,NADH_4Fe-4S
HKD2_k127_7293598_2	713587.THITH_10355	3.055e-212	689.0	COG1034@1|root,COG1034@2|Bacteria,1P8MN@1224|Proteobacteria,1RMUH@1236|Gammaproteobacteria,1WWAH@135613|Chromatiales	135613|Chromatiales	C	TIGRFAM NADH-quinone oxidoreductase, chain G	-	-	1.6.5.3	ko:K00336	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer2_4,Molybdop_Fe4S4,NADH-G_4Fe-4S_3
HKD2_k127_7293598_5	379066.GAU_2396	8.461e-140	454.0	COG1005@1|root,COG1005@2|Bacteria,1ZUSH@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	-	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
HKD2_k127_7387081_3	1122603.ATVI01000007_gene1604	2.239e-84	301.0	COG0626@1|root,COG0626@2|Bacteria,1MU57@1224|Proteobacteria,1RMCV@1236|Gammaproteobacteria,1X5QJ@135614|Xanthomonadales	135614|Xanthomonadales	E	Cys/Met metabolism PLP-dependent enzyme	-	-	2.5.1.48	ko:K01739	ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017	R00999,R01288,R02508,R03217,R03260,R04944,R04945,R04946	RC00020,RC00056,RC00069,RC00420,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000	-	-	-	Cys_Met_Meta_PP
HKD2_k127_7387081_0	1384054.N790_10990	4.389e-150	495.0	COG1461@1|root,COG1461@2|Bacteria,1NKAM@1224|Proteobacteria,1SHAC@1236|Gammaproteobacteria,1X3IB@135614|Xanthomonadales	135614|Xanthomonadales	S	Dak2	-	-	-	ko:K07030	-	-	-	-	ko00000	-	-	-	Dak2,DegV
HKD2_k127_7387081_4	1122604.JONR01000001_gene1685	3.065e-12	76.0	2CEXV@1|root,32S0S@2|Bacteria,1MZKB@1224|Proteobacteria,1T5SQ@1236|Gammaproteobacteria,1XDES@135614|Xanthomonadales	135614|Xanthomonadales	S	Type II secretion system protein B	-	-	-	-	-	-	-	-	-	-	-	-	T2SSB
HKD2_k127_7387081_1	671143.DAMO_0658	2.888e-141	466.0	COG3267@1|root,COG3409@1|root,COG3267@2|Bacteria,COG3409@2|Bacteria	2|Bacteria	M	Peptidoglycan-binding domain 1 protein	exeA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0016020,GO:0044424,GO:0044464,GO:0071944	-	ko:K02450	-	M00331	-	-	ko00000,ko00002,ko02044	9.B.42	-	-	AAA_22,PG_binding_1
HKD2_k127_7387081_2	448385.sce1364	5.792e-99	338.0	COG0389@1|root,COG0389@2|Bacteria,1MUUH@1224|Proteobacteria,42NGG@68525|delta/epsilon subdivisions,2WIVT@28221|Deltaproteobacteria,2YU4K@29|Myxococcales	28221|Deltaproteobacteria	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	dinB	-	2.7.7.7	ko:K02346	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C,IMS_HHH
HKD2_k127_7613547_4	247633.GP2143_10472	1.733e-14	78.0	COG4774@1|root,COG4774@2|Bacteria,1NMCN@1224|Proteobacteria,1T2IM@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	TonB-dependent receptor	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
HKD2_k127_7613547_0	1384054.N790_01945	2.464e-231	749.0	COG2352@1|root,COG2352@2|Bacteria,1MUD5@1224|Proteobacteria,1RPTP@1236|Gammaproteobacteria,1X4MI@135614|Xanthomonadales	135614|Xanthomonadales	C	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle	ppc	GO:0003674,GO:0003824,GO:0004611,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008964,GO:0016829,GO:0016830,GO:0016831,GO:0044424,GO:0044444,GO:0044464	4.1.1.31	ko:K01595	ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200	M00168,M00170,M00171,M00172,M00173,M00346,M00374	R00345	RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPcase
HKD2_k127_7613547_3	596154.Alide2_2260	8.935e-38	162.0	COG0494@1|root,COG0494@2|Bacteria,1NTFG@1224|Proteobacteria,2VMFZ@28216|Betaproteobacteria,4ACYZ@80864|Comamonadaceae	28216|Betaproteobacteria	L	PFAM NUDIX hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7613547_1	402626.Rpic_1440	3.544e-148	482.0	COG2130@1|root,COG2130@2|Bacteria,1MUC2@1224|Proteobacteria,2VIE7@28216|Betaproteobacteria,1K1B6@119060|Burkholderiaceae	28216|Betaproteobacteria	S	PFAM Alcohol dehydrogenase zinc-binding domain protein	-	-	-	ko:K07119	-	-	-	-	ko00000	-	-	-	ADH_N_2,ADH_zinc_N
HKD2_k127_7613547_2	697282.Mettu_3259	6.032e-119	392.0	COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,1RNKF@1236|Gammaproteobacteria,1XEUM@135618|Methylococcales	135618|Methylococcales	P	PFAM Ammonium Transporter	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
HKD2_k127_7669600_0	395494.Galf_1756	7.39e-123	402.0	COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,2VJIJ@28216|Betaproteobacteria,44V61@713636|Nitrosomonadales	28216|Betaproteobacteria	G	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties	-	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	Phosphorylase
HKD2_k127_7669600_1	203119.Cthe_2191	1.374e-114	379.0	COG0296@1|root,COG0296@2|Bacteria,1TP4M@1239|Firmicutes,247WH@186801|Clostridia,3WGDM@541000|Ruminococcaceae	186801|Clostridia	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position	glgB	-	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48
HKD2_k127_7675911_9	318167.Sfri_3329	2.03e-14	83.0	COG1409@1|root,COG1409@2|Bacteria,1MWKX@1224|Proteobacteria,1RPA7@1236|Gammaproteobacteria,2QA2T@267890|Shewanellaceae	1236|Gammaproteobacteria	S	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes	cpdA	GO:0003674,GO:0003824,GO:0004112,GO:0004114,GO:0004115,GO:0005488,GO:0005506,GO:0008081,GO:0008150,GO:0008198,GO:0009987,GO:0016043,GO:0016787,GO:0016788,GO:0042545,GO:0042578,GO:0043167,GO:0043169,GO:0045229,GO:0046872,GO:0046914,GO:0071554,GO:0071555,GO:0071840	3.1.4.53	ko:K03651	ko00230,ko02025,map00230,map02025	-	R00191	RC00296	ko00000,ko00001,ko01000	-	-	-	Metallophos
HKD2_k127_7675911_4	395961.Cyan7425_2892	6.699e-113	388.0	COG1136@1|root,COG2203@1|root,COG1136@2|Bacteria,COG2203@2|Bacteria,1G1SM@1117|Cyanobacteria,3KJGB@43988|Cyanothece	1117|Cyanobacteria	V	TIGRFAM ABC exporter ATP-binding subunit, DevA family	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD2_k127_7675911_3	493475.GARC_1986	6.937e-144	466.0	COG0577@1|root,COG0577@2|Bacteria,1PVW8@1224|Proteobacteria,1SZYK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	V	COG0577 ABC-type antimicrobial peptide transport system permease component	-	-	-	-	-	-	-	-	-	-	-	-	FtsX
HKD2_k127_7675911_8	493475.GARC_1985	8.654e-66	237.0	COG0845@1|root,COG0845@2|Bacteria	2|Bacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K01993	-	-	-	-	ko00000	-	-	-	HlyD_D23
HKD2_k127_7675911_5	404589.Anae109_3179	1.142e-97	342.0	COG1752@1|root,COG1752@2|Bacteria,1MUM9@1224|Proteobacteria,42RSN@68525|delta/epsilon subdivisions,2WNDI@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Patatin-like phospholipase	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin,cNMP_binding
HKD2_k127_7675911_7	279714.FuraDRAFT_1794	1.098e-66	234.0	COG0745@1|root,COG0745@2|Bacteria,1MWZ5@1224|Proteobacteria,2VIM1@28216|Betaproteobacteria,2KQYB@206351|Neisseriales	206351|Neisseriales	K	Transcriptional regulatory protein, C terminal	kdpE	-	-	ko:K07667	ko02020,ko02024,map02020,map02024	M00454	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
HKD2_k127_7675911_1	448385.sce1355	7.118e-243	780.0	COG0642@1|root,COG2205@2|Bacteria,1MUZQ@1224|Proteobacteria,42NZF@68525|delta/epsilon subdivisions,2WJNR@28221|Deltaproteobacteria,2YYGK@29|Myxococcales	28221|Deltaproteobacteria	T	Osmosensitive K+ channel His kinase sensor domain	kdpD	-	2.7.13.3	ko:K07646	ko02020,map02020	M00454	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	DUF4118,GAF_3,HATPase_c,HisKA,KdpD,Usp
HKD2_k127_7675911_6	1234364.AMSF01000016_gene1734	3.895e-74	253.0	COG2156@1|root,COG2156@2|Bacteria,1RABG@1224|Proteobacteria,1S2B0@1236|Gammaproteobacteria,1X6DA@135614|Xanthomonadales	135614|Xanthomonadales	P	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex	kdpC	-	3.6.3.12	ko:K01548	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	3.A.3.7	-	-	KdpC
HKD2_k127_7675911_0	795666.MW7_2884	1.06e-293	929.0	COG2216@1|root,COG2216@2|Bacteria,1MU7D@1224|Proteobacteria,2VH26@28216|Betaproteobacteria,1K1X1@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system	kdpB	-	3.6.3.12	ko:K01547	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	3.A.3.7	-	-	E1-E2_ATPase,Hydrolase
HKD2_k127_7675911_2	342113.DM82_3957	1.912e-218	694.0	COG2060@1|root,COG2060@2|Bacteria,1MV1K@1224|Proteobacteria,2VI68@28216|Betaproteobacteria	28216|Betaproteobacteria	P	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane	kdpA	-	3.6.3.12	ko:K01546	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	3.A.3.7	-	-	KdpA
HKD2_k127_7678065_4	1380394.JADL01000010_gene4324	1.078e-18	85.0	COG5598@1|root,COG5598@2|Bacteria,1MWJN@1224|Proteobacteria,2TR0V@28211|Alphaproteobacteria,2JRHD@204441|Rhodospirillales	204441|Rhodospirillales	H	Trimethylamine methyltransferase (MTTB)	-	-	-	-	-	-	-	-	-	-	-	-	MTTB
HKD2_k127_7678065_0	565045.NOR51B_1841	1.637e-157	511.0	COG0671@1|root,COG0671@2|Bacteria,1PX74@1224|Proteobacteria	1224|Proteobacteria	I	LssY C-terminus	-	-	-	-	-	-	-	-	-	-	-	-	LssY_C
HKD2_k127_7678065_1	102125.Xen7305DRAFT_00001380	1.33e-67	243.0	29K36@1|root,3070J@2|Bacteria,1G63U@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7678065_5	864702.OsccyDRAFT_3550	2.872e-10	68.0	2DBXS@1|root,2ZBR1@2|Bacteria,1G9A8@1117|Cyanobacteria,1HFXF@1150|Oscillatoriales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7678065_3	1211777.BN77_3205	8.187e-19	99.0	COG4977@1|root,COG4977@2|Bacteria,1N8W2@1224|Proteobacteria,2TXD8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	transcriptional regulator, AraC family	-	-	-	-	-	-	-	-	-	-	-	-	AraC_binding_2,HTH_18
HKD2_k127_7678065_2	1163407.UU7_05219	4.087e-24	115.0	COG1502@1|root,COG1502@2|Bacteria,1MUDJ@1224|Proteobacteria,1RMIF@1236|Gammaproteobacteria,1X4QW@135614|Xanthomonadales	135614|Xanthomonadales	I	Cardiolipin synthase	-	-	-	ko:K06132	ko00564,ko01100,map00564,map01100	-	R11062	RC00017	ko00000,ko00001,ko01000	-	-	-	PLDc_2
HKD2_k127_7724095_2	187272.Mlg_0001	5.447e-207	653.0	COG0593@1|root,COG0593@2|Bacteria,1MU5H@1224|Proteobacteria,1RNHP@1236|Gammaproteobacteria,1WW6C@135613|Chromatiales	135613|Chromatiales	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids	dnaA	-	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA,Bac_DnaA_C,DnaA_N
HKD2_k127_7724095_12	706587.Desti_3934	2.413e-13	72.0	COG0230@1|root,COG0230@2|Bacteria,1NGGS@1224|Proteobacteria,42WSU@68525|delta/epsilon subdivisions,2WSI8@28221|Deltaproteobacteria,2MSEK@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	Belongs to the bacterial ribosomal protein bL34 family	rpmH	-	-	ko:K02914	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L34
HKD2_k127_7724095_11	1283300.ATXB01000002_gene2637	4.075e-17	91.0	COG0594@1|root,COG0594@2|Bacteria,1MZQE@1224|Proteobacteria,1S90M@1236|Gammaproteobacteria,1XFKR@135618|Methylococcales	135618|Methylococcales	J	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme	rnpA	-	3.1.26.5	ko:K03536	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Ribonuclease_P
HKD2_k127_7724095_9	479435.Kfla_7084	1.717e-32	127.0	COG0759@1|root,COG0759@2|Bacteria,2GQZG@201174|Actinobacteria,4DSGI@85009|Propionibacteriales	201174|Actinobacteria	S	Could be involved in insertion of integral membrane proteins into the membrane	yidD	-	-	ko:K08998	-	-	-	-	ko00000	-	-	-	Haemolytic
HKD2_k127_7724095_5	713586.KB900536_gene2136	4.393e-142	469.0	COG0706@1|root,COG0706@2|Bacteria,1MV5M@1224|Proteobacteria,1RMH1@1236|Gammaproteobacteria,1WWKE@135613|Chromatiales	135613|Chromatiales	U	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins	yidC	-	-	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03029	2.A.9	-	-	60KD_IMP,YidC_periplas
HKD2_k127_7724095_4	1452718.JBOY01000005_gene3327	8.66e-151	490.0	COG0486@1|root,COG0486@2|Bacteria,1MUCQ@1224|Proteobacteria,1RN5S@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34	mnmE	GO:0000166,GO:0001510,GO:0001882,GO:0001883,GO:0002097,GO:0002098,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006457,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009268,GO:0009451,GO:0009628,GO:0009636,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019003,GO:0030488,GO:0030955,GO:0031420,GO:0032259,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034470,GO:0034641,GO:0034660,GO:0035639,GO:0036094,GO:0042221,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0050896,GO:0061077,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363	-	ko:K03650	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko01000,ko03016	-	-	-	MMR_HSR1,MnmE_helical,TrmE_N
HKD2_k127_7724095_10	1280950.HJO_16000	5.811e-18	97.0	COG0006@1|root,COG0006@2|Bacteria	2|Bacteria	E	proline dipeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Creatinase_N,Peptidase_M24
HKD2_k127_7724095_1	1265313.HRUBRA_01700	1.135e-208	666.0	COG1520@1|root,COG2010@1|root,COG1520@2|Bacteria,COG2010@2|Bacteria,1QXWN@1224|Proteobacteria,1T3I7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	PQQ-dependent polyvinyl alcohol dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3,PQQ,PQQ_2
HKD2_k127_7724095_7	158500.BV97_02838	2.607e-66	234.0	COG1309@1|root,COG1309@2|Bacteria,1PE94@1224|Proteobacteria,2UK8Y@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
HKD2_k127_7724095_6	314225.ELI_02500	1.743e-117	396.0	COG1020@1|root,COG1020@2|Bacteria,1N7HY@1224|Proteobacteria,2TRZV@28211|Alphaproteobacteria,2K46G@204457|Sphingomonadales	204457|Sphingomonadales	Q	Protein of unknown function (DUF1298)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1298,WES_acyltransf
HKD2_k127_7724095_14	1442599.JAAN01000045_gene2777	1.397e-06	61.0	COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,1RP75@1236|Gammaproteobacteria,1X4CP@135614|Xanthomonadales	135614|Xanthomonadales	M	RHS Repeat	-	-	-	-	-	-	-	-	-	-	-	-	RHS_repeat
HKD2_k127_7724095_0	870187.Thini_3341	7.183e-291	905.0	COG0445@1|root,COG0445@2|Bacteria,1MU6F@1224|Proteobacteria,1RMM1@1236|Gammaproteobacteria,4604K@72273|Thiotrichales	72273|Thiotrichales	D	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34	gidA	-	-	ko:K03495	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko03016,ko03036	-	-	-	GIDA,GIDA_assoc
HKD2_k127_7724095_3	1122604.JONR01000006_gene2654	7.572e-174	562.0	COG4166@1|root,COG4166@2|Bacteria,1P91R@1224|Proteobacteria,1RN57@1236|Gammaproteobacteria,1X48I@135614|Xanthomonadales	135614|Xanthomonadales	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	SBP_bac_5
HKD2_k127_7724095_13	1335760.ASTG01000001_gene3190	5.696e-12	70.0	COG1585@1|root,COG1585@2|Bacteria,1N241@1224|Proteobacteria,2UC8X@28211|Alphaproteobacteria,2K5WQ@204457|Sphingomonadales	204457|Sphingomonadales	OU	Membrane protein implicated in regulation of membrane protease activity	-	-	-	ko:K07340	-	-	-	-	ko00000	-	-	-	NfeD
HKD2_k127_7724095_8	448385.sce8345	3.204e-51	187.0	COG0386@1|root,COG0386@2|Bacteria,1RD1R@1224|Proteobacteria,42S35@68525|delta/epsilon subdivisions,2WNWS@28221|Deltaproteobacteria,2YV4G@29|Myxococcales	28221|Deltaproteobacteria	O	Belongs to the glutathione peroxidase family	bsaA	-	1.11.1.9	ko:K00432	ko00480,ko00590,ko04918,map00480,map00590,map04918	-	R00274,R07034,R07035	RC00011,RC00982	ko00000,ko00001,ko01000	-	-	-	GSHPx
HKD2_k127_7736688_3	748247.AZKH_p0305	1.605e-136	441.0	COG0842@1|root,COG0842@2|Bacteria,1MW5R@1224|Proteobacteria,2VKHP@28216|Betaproteobacteria,2KYM3@206389|Rhodocyclales	206389|Rhodocyclales	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
HKD2_k127_7736688_0	748247.AZKH_p0304	3.2e-282	877.0	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,2VHRB@28216|Betaproteobacteria,2KY9N@206389|Rhodocyclales	206389|Rhodocyclales	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD2_k127_7736688_2	748247.AZKH_p0303	2.612e-146	474.0	COG0845@1|root,COG0845@2|Bacteria,1MUG6@1224|Proteobacteria,2VH7G@28216|Betaproteobacteria,2KYHU@206389|Rhodocyclales	206389|Rhodocyclales	M	Biotin-lipoyl like	-	-	-	ko:K01993	-	-	-	-	ko00000	-	-	-	HlyD_D23
HKD2_k127_7736688_4	1095769.CAHF01000013_gene3400	9.449e-55	199.0	COG1309@1|root,COG1309@2|Bacteria,1MVQV@1224|Proteobacteria,2VK6A@28216|Betaproteobacteria,4743P@75682|Oxalobacteraceae	28216|Betaproteobacteria	K	Bacterial transcriptional repressor C-terminal	-	-	-	ko:K09017	-	-	-	-	ko00000,ko03000	-	-	-	TetR_C_11,TetR_N
HKD2_k127_7736688_1	867845.KI911784_gene2483	1.246e-261	813.0	COG2225@1|root,COG2225@2|Bacteria,2G63R@200795|Chloroflexi,374XP@32061|Chloroflexia	32061|Chloroflexia	H	TIGRFAM malate synthase A	-	-	2.3.3.9	ko:K01638	ko00620,ko00630,ko01100,ko01110,ko01120,ko01200,map00620,map00630,map01100,map01110,map01120,map01200	M00012	R00472	RC00004,RC00308,RC02747	ko00000,ko00001,ko00002,ko01000	-	-	-	Malate_synthase
HKD2_k127_7759510_1	452637.Oter_0578	2.065e-71	248.0	COG0491@1|root,COG0491@2|Bacteria	2|Bacteria	GM	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HKD2_k127_7759510_0	671143.DAMO_2206	1.275e-261	818.0	COG0488@1|root,COG0488@2|Bacteria,2NNP9@2323|unclassified Bacteria	2|Bacteria	S	ABC transporter	uup	GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008150,GO:0009314,GO:0009628,GO:0010528,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019219,GO:0019222,GO:0031323,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051171,GO:0060255,GO:0065007,GO:0070894,GO:0071944,GO:0080090,GO:0097159,GO:1901363	-	ko:K15738	-	-	-	-	ko00000,ko02000	3.A.1.120.6	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
HKD2_k127_7773386_8	1255043.TVNIR_1950	7.597e-34	131.0	COG1005@1|root,COG1005@2|Bacteria,1MU2R@1224|Proteobacteria,1RQE9@1236|Gammaproteobacteria,1WXDH@135613|Chromatiales	135613|Chromatiales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	-	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
HKD2_k127_7773386_6	713587.THITH_10345	8.196e-102	334.0	COG1143@1|root,COG1143@2|Bacteria	2|Bacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoI	GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564	1.6.5.3	ko:K00338,ko:K02573	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer4,Fer4_7
HKD2_k127_7773386_7	1255043.TVNIR_1947	1.19e-34	146.0	COG0839@1|root,COG0839@2|Bacteria	2|Bacteria	C	Belongs to the complex I subunit 6 family	nuoJ-1	-	1.6.5.3	ko:K00339	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q3
HKD2_k127_7773386_10	1379270.AUXF01000003_gene3532	2.278e-25	108.0	COG0713@1|root,COG0713@2|Bacteria,1ZV1C@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	-	1.6.5.3	ko:K00340	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q2
HKD2_k127_7773386_1	379066.GAU_2392	4.742e-268	837.0	COG1009@1|root,COG1009@2|Bacteria,1ZUA7@142182|Gemmatimonadetes	142182|Gemmatimonadetes	CP	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus	-	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M,Proton_antipo_N
HKD2_k127_7773386_3	1379698.RBG1_1C00001G1061	3.409e-148	486.0	COG1008@1|root,COG1008@2|Bacteria,2NNQ9@2323|unclassified Bacteria	2|Bacteria	C	NADH-quinone oxidoreductase, chain M	nuoM-1	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q5_N,Proton_antipo_M
HKD2_k127_7773386_4	1379270.AUXF01000003_gene3535	9.298e-147	485.0	COG1007@1|root,COG1007@2|Bacteria,1ZUR0@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	-	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
HKD2_k127_7773386_9	518766.Rmar_2587	2.09e-27	117.0	COG0664@1|root,COG0664@2|Bacteria	2|Bacteria	T	cyclic nucleotide binding	crp	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	cNMP_binding
HKD2_k127_7773386_5	1095769.CAHF01000011_gene2126	3.314e-140	461.0	COG1804@1|root,COG1804@2|Bacteria,1MW1H@1224|Proteobacteria,2VJJQ@28216|Betaproteobacteria,474FP@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	CoA-transferase family III	-	-	5.1.99.4	ko:K01796	ko00120,ko01100,ko04146,map00120,map01100,map04146	M00104	R08734,R08739	RC02345	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_transf_3
HKD2_k127_7773386_2	1502852.FG94_03986	5.302e-154	501.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2VH9Y@28216|Betaproteobacteria,476JS@75682|Oxalobacteraceae	28216|Betaproteobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HKD2_k127_7773386_0	765911.Thivi_3657	1.837e-290	902.0	COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,1RN8P@1236|Gammaproteobacteria,1WVYX@135613|Chromatiales	1236|Gammaproteobacteria	G	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties	-	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	Phosphorylase
HKD2_k127_7780626_15	1335757.SPICUR_01525	1.004e-38	147.0	COG0689@1|root,COG0689@2|Bacteria,1MVFZ@1224|Proteobacteria,1RNTB@1236|Gammaproteobacteria,1WW0F@135613|Chromatiales	135613|Chromatiales	J	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates	rph	-	2.7.7.56	ko:K00989	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RNase_PH,RNase_PH_C
HKD2_k127_7780626_9	1158182.KB905024_gene107	1.766e-68	244.0	COG0127@1|root,COG0127@2|Bacteria,1MUK5@1224|Proteobacteria,1S27C@1236|Gammaproteobacteria,1WWJX@135613|Chromatiales	135613|Chromatiales	F	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions	-	-	3.6.1.66	ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000	-	-	-	Ham1p_like
HKD2_k127_7780626_6	1163409.UUA_05832	2.241e-132	434.0	COG0635@1|root,COG0635@2|Bacteria,1MU76@1224|Proteobacteria,1RN6I@1236|Gammaproteobacteria,1X32N@135614|Xanthomonadales	135614|Xanthomonadales	H	Involved in the biosynthesis of porphyrin-containing compound	-	-	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
HKD2_k127_7780626_16	243233.MCA0322	1.001e-30	121.0	COG0254@1|root,COG0254@2|Bacteria,1MZ69@1224|Proteobacteria,1SCMH@1236|Gammaproteobacteria,1XFM3@135618|Methylococcales	135618|Methylococcales	J	Binds the 23S rRNA	rpmE	-	-	ko:K02909	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L31
HKD2_k127_7780626_7	1395571.TMS3_0105400	1.736e-131	435.0	COG4784@1|root,COG4784@2|Bacteria,1QTT7@1224|Proteobacteria,1RSQ1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Zn-dependent protease	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
HKD2_k127_7780626_3	1415780.JPOG01000001_gene27	9.631e-198	624.0	COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,1RNDK@1236|Gammaproteobacteria,1X3KV@135614|Xanthomonadales	135614|Xanthomonadales	C	Belongs to the citrate synthase family	gltA	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
HKD2_k127_7780626_12	1033802.SSPSH_003537	1.997e-49	183.0	COG2413@1|root,COG2413@2|Bacteria,1RFTH@1224|Proteobacteria,1T4QX@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7780626_0	105559.Nwat_0344	2.351e-232	746.0	COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,1RM7J@1236|Gammaproteobacteria,1WWH1@135613|Chromatiales	135613|Chromatiales	M	TIGRFAM penicillin-binding protein, 1A	-	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	PCB_OB,Transgly,Transpeptidase
HKD2_k127_7780626_8	1122604.JONR01000010_gene3934	1.322e-109	364.0	COG4972@1|root,COG4972@2|Bacteria,1MX8P@1224|Proteobacteria,1RN8S@1236|Gammaproteobacteria,1X3US@135614|Xanthomonadales	135614|Xanthomonadales	NU	Pilus assembly protein	pilM	-	-	ko:K02662	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilM_2
HKD2_k127_7780626_13	1049564.TevJSym_bb00150	6.277e-46	172.0	COG3166@1|root,COG3166@2|Bacteria,1RF1S@1224|Proteobacteria,1S3S0@1236|Gammaproteobacteria,1J61K@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	NU	COG3166 Tfp pilus assembly protein PilN	pilN	-	-	ko:K02663	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilN
HKD2_k127_7780626_10	1123256.KB907925_gene1205	1.022e-59	215.0	COG3167@1|root,COG3167@2|Bacteria,1RBGW@1224|Proteobacteria,1S3XQ@1236|Gammaproteobacteria,1X4H8@135614|Xanthomonadales	135614|Xanthomonadales	NU	Pilus assembly protein, PilO	pilO	-	-	ko:K02664	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilO
HKD2_k127_7780626_14	1415779.JOMH01000001_gene644	1.441e-40	164.0	COG3168@1|root,COG3168@2|Bacteria,1RI6V@1224|Proteobacteria,1S6VJ@1236|Gammaproteobacteria,1X61Y@135614|Xanthomonadales	135614|Xanthomonadales	NU	pilus assembly protein pilp	pilP	-	-	ko:K02665	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilP
HKD2_k127_7780626_2	1122603.ATVI01000006_gene499	5.215e-202	652.0	COG4796@1|root,COG4796@2|Bacteria,1QTT6@1224|Proteobacteria,1RN3Z@1236|Gammaproteobacteria,1X3SF@135614|Xanthomonadales	135614|Xanthomonadales	U	Type II secretory pathway, component HofQ	pilQ	-	-	ko:K02666	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	AMIN,STN,Secretin,Secretin_N
HKD2_k127_7780626_11	1123261.AXDW01000003_gene1860	3.77e-55	198.0	COG0703@1|root,COG0703@2|Bacteria,1MUFJ@1224|Proteobacteria,1RPF6@1236|Gammaproteobacteria,1X6GJ@135614|Xanthomonadales	135614|Xanthomonadales	F	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate	aroK	GO:0000287,GO:0003674,GO:0003824,GO:0004765,GO:0005488,GO:0006082,GO:0006520,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019438,GO:0019632,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046872,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615	2.7.1.71	ko:K00891	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	SKI
HKD2_k127_7780626_5	765910.MARPU_16470	9.275e-137	452.0	COG0337@1|root,COG0337@2|Bacteria,1MUBK@1224|Proteobacteria,1RN4I@1236|Gammaproteobacteria,1WWZW@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)	aroB	-	4.2.3.4	ko:K01735	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03083	RC00847	ko00000,ko00001,ko00002,ko01000	-	-	-	DHQ_synthase
HKD2_k127_7780626_4	713586.KB900536_gene1839	2.564e-157	516.0	COG0232@1|root,COG0232@2|Bacteria,1MVQ2@1224|Proteobacteria,1RPVJ@1236|Gammaproteobacteria,1X0VD@135613|Chromatiales	135613|Chromatiales	F	Belongs to the dGTPase family. Type 2 subfamily	-	-	3.1.5.1	ko:K01129	ko00230,map00230	-	R01856	RC00017	ko00000,ko00001,ko01000	-	-	-	HD,HD_assoc
HKD2_k127_7780626_1	1229780.BN381_100111	1.627e-220	694.0	COG1012@1|root,COG1012@2|Bacteria,2GIWZ@201174|Actinobacteria,3UWBH@52018|unclassified Actinobacteria (class)	201174|Actinobacteria	C	Belongs to the aldehyde dehydrogenase family	-	-	1.2.1.8	ko:K00130	ko00260,ko01100,map00260,map01100	M00555	R02565,R02566	RC00080	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
HKD2_k127_7786866_0	1232410.KI421413_gene539	8.391e-167	537.0	COG0034@1|root,COG0034@2|Bacteria,1MU0V@1224|Proteobacteria,42MDB@68525|delta/epsilon subdivisions,2WITV@28221|Deltaproteobacteria,43RZA@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Glutamine amidotransferases class-II	purF	-	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_6,GATase_7,Pribosyltran
HKD2_k127_7786866_1	1121430.JMLG01000005_gene785	4.04e-154	516.0	COG0015@1|root,COG0015@2|Bacteria,1TPMM@1239|Firmicutes,2485N@186801|Clostridia,260RX@186807|Peptococcaceae	186801|Clostridia	F	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily	purB	-	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	-	ADSL_C,Lyase_1
HKD2_k127_7786866_2	234267.Acid_7201	6.061e-122	404.0	COG0612@1|root,COG0612@2|Bacteria,3Y3M9@57723|Acidobacteria	57723|Acidobacteria	S	Belongs to the peptidase M16 family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
HKD2_k127_7786866_3	1507.HMPREF0262_02231	3.428e-13	75.0	COG0820@1|root,COG0820@2|Bacteria,1TPVF@1239|Firmicutes,248BC@186801|Clostridia,36E1B@31979|Clostridiaceae	186801|Clostridia	J	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs	rlmN	-	2.1.1.192	ko:K06941	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Fer4_14,Radical_SAM
HKD2_k127_7806853_2	379066.GAU_2398	1.387e-63	228.0	COG1894@1|root,COG1894@2|Bacteria,1ZUDU@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region	-	-	1.6.5.3	ko:K00335	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_51K,NADH_4Fe-4S
HKD2_k127_7806853_1	1255043.TVNIR_1953	4.362e-75	254.0	COG1905@1|root,COG1905@2|Bacteria,1RHBU@1224|Proteobacteria,1T09A@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	COG1905 NADH ubiquinone oxidoreductase 24 kD subunit	-	-	1.6.5.3	ko:K00127,ko:K00334	ko00190,ko00630,ko00680,ko01100,ko01120,ko01200,map00190,map00630,map00680,map01100,map01120,map01200	M00144	R00519,R11945	RC00061,RC02796	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
HKD2_k127_7806853_0	1255043.TVNIR_1954	4.889e-208	649.0	COG0649@1|root,COG0649@2|Bacteria,1MVIN@1224|Proteobacteria,1RM98@1236|Gammaproteobacteria,1WWN5@135613|Chromatiales	135613|Chromatiales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	-	1.6.5.3	ko:K00333	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa
HKD2_k127_7839252_52	1042377.AFPJ01000008_gene1970	1.212e-54	199.0	28PH0@1|root,2ZC7M@2|Bacteria,1R6YG@1224|Proteobacteria,1SK8N@1236|Gammaproteobacteria,469TU@72275|Alteromonadaceae	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7839252_26	555088.DealDRAFT_3112	1.062e-134	438.0	COG0332@1|root,COG0332@2|Bacteria,1TP0K@1239|Firmicutes,248V8@186801|Clostridia,42JKV@68298|Syntrophomonadaceae	186801|Clostridia	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	-	-	-	-	-	-	-	-	-	-	-	-	ACP_syn_III,ACP_syn_III_C
HKD2_k127_7839252_32	1384054.N790_07355	4.648e-107	355.0	COG0697@1|root,COG0697@2|Bacteria,1N4MD@1224|Proteobacteria,1SZQ5@1236|Gammaproteobacteria,1X4YA@135614|Xanthomonadales	135614|Xanthomonadales	EG	Permeases of the drug metabolite transporter (DMT) superfamily	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HKD2_k127_7839252_51	1442599.JAAN01000024_gene1909	6.122e-56	203.0	COG2717@1|root,COG2717@2|Bacteria,1RDUP@1224|Proteobacteria,1RS9K@1236|Gammaproteobacteria,1X631@135614|Xanthomonadales	135614|Xanthomonadales	C	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain	msrQ	-	-	ko:K17247	-	-	-	-	ko00000	-	-	-	Ferric_reduct
HKD2_k127_7839252_29	1249627.D779_2555	4.708e-125	407.0	COG2041@1|root,COG2041@2|Bacteria,1MUW0@1224|Proteobacteria,1RQ2J@1236|Gammaproteobacteria,1WXW8@135613|Chromatiales	135613|Chromatiales	C	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide	msrP	-	-	ko:K07147	-	-	-	-	ko00000,ko01000	-	-	-	Oxidored_molyb
HKD2_k127_7839252_44	42256.RradSPS_1336	1.338e-80	284.0	COG0846@1|root,COG0846@2|Bacteria,2GJI3@201174|Actinobacteria,4CU5Y@84995|Rubrobacteria	84995|Rubrobacteria	K	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form	-	-	-	ko:K12410	-	-	-	-	ko00000,ko01000	-	-	-	SIR2
HKD2_k127_7839252_0	743721.Psesu_1697	0.0	1239.0	COG1048@1|root,COG1048@2|Bacteria,1MU9T@1224|Proteobacteria,1RN5I@1236|Gammaproteobacteria,1X3SP@135614|Xanthomonadales	135614|Xanthomonadales	C	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate	acnA	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
HKD2_k127_7839252_25	1134474.O59_002328	1.591e-135	442.0	COG0482@1|root,COG0482@2|Bacteria,1MUT1@1224|Proteobacteria,1RMAK@1236|Gammaproteobacteria,1FG0P@10|Cellvibrio	1236|Gammaproteobacteria	J	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34	mnmA	GO:0001510,GO:0002097,GO:0002098,GO:0002143,GO:0003674,GO:0003824,GO:0004808,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016782,GO:0016783,GO:0030488,GO:0032259,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.8.1.13	ko:K00566	ko04122,map04122	-	R08700	RC02313,RC02315	ko00000,ko00001,ko01000,ko03016	-	-	-	tRNA_Me_trans
HKD2_k127_7839252_54	1123368.AUIS01000006_gene584	1.913e-51	187.0	COG1051@1|root,COG1051@2|Bacteria,1N03W@1224|Proteobacteria,1S970@1236|Gammaproteobacteria,2NCZI@225057|Acidithiobacillales	225057|Acidithiobacillales	F	Belongs to the Nudix hydrolase family. NudJ subfamily	nudJ	-	-	-	-	-	-	-	-	-	-	-	NUDIX
HKD2_k127_7839252_65	572477.Alvin_0841	4.579e-23	105.0	COG2153@1|root,COG2153@2|Bacteria,1N7TN@1224|Proteobacteria,1SCI6@1236|Gammaproteobacteria,1WYQK@135613|Chromatiales	135613|Chromatiales	S	protein acetylation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7839252_63	1123253.AUBD01000001_gene1715	1.134e-31	130.0	COG2153@1|root,COG2153@2|Bacteria,1MZ86@1224|Proteobacteria,1S8SK@1236|Gammaproteobacteria,1X5TH@135614|Xanthomonadales	135614|Xanthomonadales	S	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_10
HKD2_k127_7839252_15	768671.ThimaDRAFT_2420	1.776e-185	589.0	COG0015@1|root,COG0015@2|Bacteria,1MV4B@1224|Proteobacteria,1RN93@1236|Gammaproteobacteria,1WW57@135613|Chromatiales	135613|Chromatiales	F	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily	-	-	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	-	ASL_C,Lyase_1
HKD2_k127_7839252_21	1122212.AULO01000011_gene640	7.892e-171	552.0	COG0114@1|root,COG0114@2|Bacteria,1MUQI@1224|Proteobacteria,1RNUS@1236|Gammaproteobacteria,1XI5H@135619|Oceanospirillales	135619|Oceanospirillales	C	Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate	fumC	-	4.2.1.2	ko:K01679	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211	M00009,M00011,M00173,M00376	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	FumaraseC_C,Lyase_1
HKD2_k127_7839252_55	522306.CAP2UW1_2142	4.85e-51	188.0	COG0494@1|root,COG0494@2|Bacteria,1RD2C@1224|Proteobacteria,2VREV@28216|Betaproteobacteria,1KQQ5@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	L	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
HKD2_k127_7839252_42	1380394.JADL01000005_gene5463	5.977e-85	293.0	COG1694@1|root,COG3956@2|Bacteria,1MVKM@1224|Proteobacteria,2TRC9@28211|Alphaproteobacteria,2JPGN@204441|Rhodospirillales	204441|Rhodospirillales	S	MazG nucleotide pyrophosphohydrolase domain	mazG	-	3.6.1.9	ko:K04765	ko00230,ko00240,ko00760,ko00770,ko01100,map00230,map00240,map00760,map00770,map01100	-	R00086,R00087,R00103,R00287,R00426,R00515,R00662,R00720,R03004,R03036,R11323	RC00002	ko00000,ko00001,ko01000	-	-	-	MazG
HKD2_k127_7839252_2	472759.Nhal_1290	2.5e-323	1033.0	COG1643@1|root,COG1643@2|Bacteria,1MUEQ@1224|Proteobacteria,1RMU1@1236|Gammaproteobacteria,1WWGW@135613|Chromatiales	135613|Chromatiales	L	TIGRFAM ATP-dependent helicase HrpA	-	-	3.6.4.13	ko:K03578	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,DUF3418,HA2,Helicase_C,OB_NTP_bind
HKD2_k127_7839252_38	314345.SPV1_08266	2.325e-92	322.0	COG0330@1|root,COG0330@2|Bacteria,1MUM8@1224|Proteobacteria	1224|Proteobacteria	O	COG0330 Membrane protease subunits stomatin prohibitin homologs	qmcA	-	-	-	-	-	-	-	-	-	-	-	Band_7
HKD2_k127_7839252_24	314278.NB231_00740	3.369e-141	477.0	COG1030@1|root,COG1030@2|Bacteria,1MUJN@1224|Proteobacteria,1RN3U@1236|Gammaproteobacteria,1WXRD@135613|Chromatiales	135613|Chromatiales	O	NfeD-like C-terminal, partner-binding	-	-	-	ko:K07403	-	-	-	-	ko00000	-	-	-	NfeD
HKD2_k127_7839252_45	195250.CM001776_gene1121	4.773e-79	274.0	COG0491@1|root,COG0491@2|Bacteria,1G400@1117|Cyanobacteria,1H175@1129|Synechococcus	1117|Cyanobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HKD2_k127_7839252_9	297246.lpp1305	5.771e-202	663.0	COG1012@1|root,COG1012@2|Bacteria,1MW72@1224|Proteobacteria,1RY9G@1236|Gammaproteobacteria,1JE37@118969|Legionellales	118969|Legionellales	C	Aldehyde dehydrogenase family	-	-	1.2.1.3	ko:K00128	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
HKD2_k127_7839252_27	330214.NIDE4063	5.273e-134	443.0	COG1748@1|root,COG1748@2|Bacteria	2|Bacteria	E	saccharopine dehydrogenase activity	lysDH	-	1.5.1.7	ko:K00290	ko00300,ko00310,ko01100,ko01110,ko01130,ko01230,map00300,map00310,map01100,map01110,map01130,map01230	M00030,M00032	R00715	RC00217,RC01532	ko00000,ko00001,ko00002,ko01000	-	-	-	ELFV_dehydrog,Sacchrp_dh_C,Sacchrp_dh_NADP
HKD2_k127_7839252_10	1123261.AXDW01000005_gene2633	2.101e-199	629.0	COG3200@1|root,COG3200@2|Bacteria,1MUWF@1224|Proteobacteria,1RRMM@1236|Gammaproteobacteria,1X2YX@135614|Xanthomonadales	135614|Xanthomonadales	E	phospho-2-dehydro-3-deoxyheptonate aldolase	dhs1	-	2.5.1.54	ko:K01626	ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_2
HKD2_k127_7839252_46	1121033.AUCF01000008_gene5695	4.857e-71	252.0	COG1187@1|root,COG1187@2|Bacteria,1R9VV@1224|Proteobacteria,2U5H3@28211|Alphaproteobacteria,2JRS2@204441|Rhodospirillales	204441|Rhodospirillales	J	Belongs to the pseudouridine synthase RsuA family	rluE	-	5.4.99.20	ko:K06181	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2
HKD2_k127_7839252_5	1382304.JNIL01000001_gene3128	1.081e-238	750.0	COG2225@1|root,COG2225@2|Bacteria,1TPE8@1239|Firmicutes,4H9ST@91061|Bacilli,279F3@186823|Alicyclobacillaceae	91061|Bacilli	C	Malate synthase	aceB	-	2.3.3.9	ko:K01638	ko00620,ko00630,ko01100,ko01110,ko01120,ko01200,map00620,map00630,map01100,map01110,map01120,map01200	M00012	R00472	RC00004,RC00308,RC02747	ko00000,ko00001,ko00002,ko01000	-	-	-	Malate_synthase
HKD2_k127_7839252_7	279714.FuraDRAFT_1222	4.538e-237	737.0	COG2224@1|root,COG2224@2|Bacteria,1MWIF@1224|Proteobacteria,2VHWS@28216|Betaproteobacteria,2KQMU@206351|Neisseriales	206351|Neisseriales	C	Phosphoenolpyruvate phosphomutase	-	-	4.1.3.1	ko:K01637	ko00630,ko01100,ko01110,ko01120,ko01200,map00630,map01100,map01110,map01120,map01200	M00012	R00479	RC00311,RC00313	ko00000,ko00001,ko00002,ko01000	-	-	-	ICL
HKD2_k127_7839252_43	396588.Tgr7_1908	1.023e-84	285.0	COG1573@1|root,COG1573@2|Bacteria,1MW91@1224|Proteobacteria,1S2B6@1236|Gammaproteobacteria,1X0E4@135613|Chromatiales	135613|Chromatiales	L	Uracil DNA glycosylase superfamily	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
HKD2_k127_7839252_13	247633.GP2143_14881	1.322e-191	625.0	COG1629@1|root,COG4771@2|Bacteria,1QXX8@1224|Proteobacteria	1224|Proteobacteria	M	Outer membrane receptor	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
HKD2_k127_7839252_56	1265313.HRUBRA_00446	1.045e-48	181.0	COG4319@1|root,COG4319@2|Bacteria,1RIDW@1224|Proteobacteria	1224|Proteobacteria	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_4
HKD2_k127_7839252_20	1265313.HRUBRA_00447	5.693e-176	560.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,1RMMJ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	acyl-CoA dehydrogenase	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HKD2_k127_7839252_49	247633.GP2143_03428	1.285e-61	215.0	COG3777@1|root,COG3777@2|Bacteria,1QXWM@1224|Proteobacteria,1SSG2@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	N-terminal half of MaoC dehydratase	-	-	4.2.1.153	ko:K09709	ko00720,ko01120,ko01200,map00720,map01120,map01200	M00376	R09282	RC02479	ko00000,ko00001,ko00002,ko01000	-	-	-	MaoC_dehydrat_N
HKD2_k127_7839252_58	565045.NOR51B_415	2.835e-44	165.0	COG3777@1|root,COG3777@2|Bacteria,1RIJT@1224|Proteobacteria,1RMS2@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7839252_62	247633.GP2143_03443	5.867e-33	145.0	COG1545@1|root,COG1545@2|Bacteria,1N7HH@1224|Proteobacteria,1SY5W@1236|Gammaproteobacteria,1JBBQ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Rubredoxin-like zinc ribbon domain (DUF35_N)	-	-	-	-	-	-	-	-	-	-	-	-	DUF35_N,OB_aCoA_assoc
HKD2_k127_7839252_14	247633.GP2143_03438	1.448e-186	590.0	COG0183@1|root,COG0183@2|Bacteria,1MUZV@1224|Proteobacteria,1RN81@1236|Gammaproteobacteria,1JAH3@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	I	COG0183 Acetyl-CoA acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Thiolase_C,Thiolase_N
HKD2_k127_7839252_66	929712.KI912613_gene706	1.416e-19	92.0	COG0535@1|root,COG0535@2|Bacteria,2GQQT@201174|Actinobacteria,4CTWU@84995|Rubrobacteria	84995|Rubrobacteria	S	Mycofactocin system	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7839252_18	656024.FsymDg_2656	2.242e-182	579.0	COG0535@1|root,COG0535@2|Bacteria,2GNSY@201174|Actinobacteria,4ERFC@85013|Frankiales	201174|Actinobacteria	C	Radical SAM domain protein	pqqE	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM,SPASM
HKD2_k127_7839252_4	298655.KI912266_gene2260	4.598e-242	764.0	COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,2GMB6@201174|Actinobacteria	201174|Actinobacteria	C	NADH flavin oxidoreductase NADH oxidase	-	-	1.3.1.34	ko:K00219	-	-	-	-	ko00000,ko01000	-	-	-	NAD_binding_8,Oxidored_FMN,Pyr_redox,Pyr_redox_2
HKD2_k127_7839252_1	656024.FsymDg_2654	0.0	1022.0	COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,2GK8E@201174|Actinobacteria	201174|Actinobacteria	C	NADH flavin oxidoreductase NADH oxidase	-	-	1.3.1.34	ko:K00219	-	-	-	-	ko00000,ko01000	-	-	-	FAD_oxidored,Oxidored_FMN,Pyr_redox_2
HKD2_k127_7839252_34	656024.FsymDg_2653	9.218e-105	351.0	COG2025@1|root,COG2025@2|Bacteria,2IIKX@201174|Actinobacteria	201174|Actinobacteria	C	Electron transfer flavoprotein alpha subunit	-	-	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	-	ETF,ETF_alpha
HKD2_k127_7839252_11	656024.FsymDg_2652	3.753e-198	627.0	COG0644@1|root,COG0644@2|Bacteria	2|Bacteria	C	geranylgeranyl reductase activity	-	-	-	ko:K00313	-	-	-	-	ko00000,ko01000	-	-	-	DAO,FAD_binding_3,FAD_oxidored,Pyr_redox_2
HKD2_k127_7839252_60	298654.FraEuI1c_4678	3.273e-42	161.0	COG2440@1|root,COG2440@2|Bacteria,2IQVY@201174|Actinobacteria	201174|Actinobacteria	C	electron transfer flavoprotein-ubiquinone oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	ETF_QO,Fer4_9
HKD2_k127_7839252_40	656024.FsymDg_2650	1.344e-88	302.0	COG2086@1|root,COG2086@2|Bacteria,2GSWB@201174|Actinobacteria	201174|Actinobacteria	C	Electron transfer flavoprotein	-	-	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
HKD2_k127_7839252_47	1110697.NCAST_32_01600	1.164e-68	249.0	COG1402@1|root,COG1402@2|Bacteria,2HCRK@201174|Actinobacteria,4FYMR@85025|Nocardiaceae	201174|Actinobacteria	S	Creatinine amidohydrolase	mftE	-	3.5.2.10	ko:K01470	ko00330,map00330	-	R01884	RC00615	ko00000,ko00001,ko01000	-	-	-	Creatininase
HKD2_k127_7839252_48	882083.SacmaDRAFT_1195	1.921e-66	237.0	COG1028@1|root,COG1028@2|Bacteria,2ICJK@201174|Actinobacteria,4E3I3@85010|Pseudonocardiales	201174|Actinobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HKD2_k127_7839252_33	330084.JNYZ01000007_gene8741	3.827e-106	362.0	COG1216@1|root,COG1216@2|Bacteria,2I3S5@201174|Actinobacteria,4DZIU@85010|Pseudonocardiales	201174|Actinobacteria	S	Glycosyl transferase family 21	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HKD2_k127_7839252_37	526226.Gbro_1689	1.199e-93	315.0	COG1028@1|root,COG1028@2|Bacteria,2GP7P@201174|Actinobacteria,4GA4B@85026|Gordoniaceae	201174|Actinobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HKD2_k127_7839252_16	76114.p2A394	1.679e-184	585.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2VHMS@28216|Betaproteobacteria,2KXS8@206389|Rhodocyclales	206389|Rhodocyclales	I	Acetyl-CoA acetyltransferase	-	-	2.3.1.16	ko:K00632	ko00071,ko00280,ko00281,ko00362,ko00592,ko00642,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00362,map00592,map00642,map01100,map01110,map01120,map01130,map01212	M00087,M00113	R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000	-	-	-	Thiolase_C,Thiolase_N
HKD2_k127_7839252_31	266265.Bxe_C0596	2.209e-118	388.0	COG1250@1|root,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,2VGZU@28216|Betaproteobacteria,1K0VY@119060|Burkholderiaceae	28216|Betaproteobacteria	I	Dehydrogenase	-	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
HKD2_k127_7839252_35	366602.Caul_1904	1.504e-96	324.0	COG1024@1|root,COG1024@2|Bacteria,1MWZC@1224|Proteobacteria,2U6J4@28211|Alphaproteobacteria,2KIA1@204458|Caulobacterales	204458|Caulobacterales	I	Enoyl-CoA hydratase/isomerase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
HKD2_k127_7839252_17	935565.JAEM01000016_gene1474	1.668e-182	578.0	COG1960@1|root,COG1960@2|Bacteria,1MX17@1224|Proteobacteria,2TTRE@28211|Alphaproteobacteria,2PYFF@265|Paracoccus	28211|Alphaproteobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	ko:K18244	-	-	-	-	ko00000,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HKD2_k127_7839252_28	402881.Plav_1983	4.033e-128	418.0	COG3618@1|root,COG3618@2|Bacteria,1MVG0@1224|Proteobacteria,2TRU9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	metal-dependent hydrolase of the TIM-barrel fold	-	-	-	ko:K07046	ko00051,ko01120,map00051,map01120	-	R10689	RC00537	ko00000,ko00001,ko01000	-	-	-	Amidohydro_2
HKD2_k127_7839252_57	1265313.HRUBRA_00277	7.678e-47	185.0	COG1309@1|root,COG1309@2|Bacteria,1R6ZE@1224|Proteobacteria	1224|Proteobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_6,TetR_N
HKD2_k127_7839252_39	675635.Psed_2584	1.817e-90	304.0	COG1028@1|root,COG1028@2|Bacteria,2IAJK@201174|Actinobacteria,4E8F8@85010|Pseudonocardiales	201174|Actinobacteria	IQ	NAD dependent epimerase/dehydratase family	-	-	1.1.1.127	ko:K00065	ko00040,map00040	-	R01542	RC00089	ko00000,ko00001,ko01000	-	-	-	adh_short_C2
HKD2_k127_7839252_23	675635.Psed_2575	1.875e-141	460.0	COG1960@1|root,COG1960@2|Bacteria,2GK1M@201174|Actinobacteria,4E8YQ@85010|Pseudonocardiales	201174|Actinobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HKD2_k127_7839252_30	675635.Psed_2565	1.021e-121	398.0	COG0447@1|root,COG0447@2|Bacteria,2HGHM@201174|Actinobacteria,4EA63@85010|Pseudonocardiales	201174|Actinobacteria	H	Enoyl-CoA hydratase/isomerase	-	-	4.1.3.36	ko:K01661,ko:K07536	ko00130,ko00362,ko01100,ko01110,ko01120,ko01220,map00130,map00362,map01100,map01110,map01120,map01220	M00116,M00540	R05592,R07263	RC01429,RC01923	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
HKD2_k127_7839252_41	76114.p2A352	5.78e-88	293.0	COG3871@1|root,COG3871@2|Bacteria	2|Bacteria	S	Pyridoxamine 5'-phosphate oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
HKD2_k127_7839252_6	1268068.PG5_02110	4.51e-237	744.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,1RMQ4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	IQ	COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II	caiC	GO:0003674,GO:0003824,GO:0016405,GO:0016874,GO:0016877,GO:0016879,GO:0016881,GO:0051108,GO:0051109	6.2.1.48	ko:K02182	-	-	-	-	ko00000,ko01000	-	-	iECSE_1348.ECSE_0038,iNRG857_1313.NRG857_00195	AMP-binding,AMP-binding_C
HKD2_k127_7839252_19	76114.p2A2	1.505e-178	577.0	COG1053@1|root,COG1053@2|Bacteria,1MURY@1224|Proteobacteria,2VJYH@28216|Betaproteobacteria,2KXXI@206389|Rhodocyclales	206389|Rhodocyclales	C	COG1053 Succinate dehydrogenase fumarate reductase, flavoprotein subunit	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_2
HKD2_k127_7839252_64	1123367.C666_11410	7.456e-26	111.0	COG2010@1|root,COG2010@2|Bacteria,1N7I9@1224|Proteobacteria	1224|Proteobacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7839252_53	469371.Tbis_2525	7.934e-53	190.0	COG3631@1|root,COG3631@2|Bacteria,2GS8C@201174|Actinobacteria,4E7JJ@85010|Pseudonocardiales	201174|Actinobacteria	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_4
HKD2_k127_7839252_59	1348657.M622_02930	1.426e-43	167.0	COG1920@1|root,COG1920@2|Bacteria,1RJPN@1224|Proteobacteria,2VWWX@28216|Betaproteobacteria,2KZF9@206389|Rhodocyclales	206389|Rhodocyclales	H	Guanylyltransferase that catalyzes the activation of 2- phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor	cofC	-	2.7.7.68	ko:K14941	ko00680,ko01120,map00680,map01120	M00378	R09397	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CofC
HKD2_k127_7839252_3	392499.Swit_0717	4.16e-312	976.0	COG1060@1|root,COG1060@2|Bacteria,1MX50@1224|Proteobacteria,2TRX7@28211|Alphaproteobacteria,2K174@204457|Sphingomonadales	204457|Sphingomonadales	H	Elongator protein 3, MiaB family, Radical SAM	-	-	2.5.1.77	ko:K11779	ko00680,ko01120,map00680,map01120	M00378	R09396	RC01381,RC03002,RC03007	ko00000,ko00001,ko00002,ko01000	-	-	-	Radical_SAM
HKD2_k127_7839252_22	1168059.KB899087_gene2595	1.688e-167	532.0	COG2141@1|root,COG2141@2|Bacteria,1MXQU@1224|Proteobacteria,2U1X1@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
HKD2_k127_7839252_36	1168059.KB899087_gene2594	1.281e-94	316.0	COG1478@1|root,COG1478@2|Bacteria,1PQHN@1224|Proteobacteria,2TU1P@28211|Alphaproteobacteria,3F0WC@335928|Xanthobacteraceae	28211|Alphaproteobacteria	S	F420-0:Gamma-glutamyl ligase	cofE	-	6.3.2.31,6.3.2.34	ko:K12234	ko00680,ko01120,map00680,map01120	M00378	R09399,R09400	RC00064,RC00090,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_ligase
HKD2_k127_7839252_8	1121335.Clst_2416	1.127e-219	690.0	COG0362@1|root,COG0362@2|Bacteria,1TP4I@1239|Firmicutes,248YA@186801|Clostridia	186801|Clostridia	H	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH	gnd	-	1.1.1.343,1.1.1.44	ko:K00033	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200	M00004,M00006	R01528,R10221	RC00001,RC00539	ko00000,ko00001,ko00002,ko01000	-	-	-	6PGD,NAD_binding_2
HKD2_k127_7839252_61	929712.KI912613_gene858	9.396e-42	162.0	28KGF@1|root,2ZA28@2|Bacteria,2ICYP@201174|Actinobacteria,4CQKM@84995|Rubrobacteria	84995|Rubrobacteria	S	EthD domain	-	-	-	-	-	-	-	-	-	-	-	-	EthD
HKD2_k127_7839252_12	396588.Tgr7_1907	1.148e-192	641.0	COG0322@1|root,COG0322@2|Bacteria,1MV38@1224|Proteobacteria,1RNGV@1236|Gammaproteobacteria,1WWEF@135613|Chromatiales	135613|Chromatiales	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	-	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N
HKD2_k127_7839252_50	2340.JV46_03770	4.476e-60	213.0	COG0558@1|root,COG0558@2|Bacteria,1RCZ7@1224|Proteobacteria,1S465@1236|Gammaproteobacteria,1J656@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pgsA	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008444,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016772,GO:0016780,GO:0017169,GO:0019637,GO:0031224,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044425,GO:0044464,GO:0045017,GO:0046474,GO:0046486,GO:0071704,GO:0071944,GO:0090407,GO:1901576	2.7.8.41,2.7.8.5	ko:K00995,ko:K08744	ko00564,ko01100,map00564,map01100	-	R01801,R02030	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	iAF1260.b1912,iAPECO1_1312.APECO1_954,iB21_1397.B21_01866,iBWG_1329.BWG_1721,iE2348C_1286.E2348C_2030,iEC042_1314.EC042_2073,iEC55989_1330.EC55989_2132,iECABU_c1320.ECABU_c21710,iECBD_1354.ECBD_1731,iECB_1328.ECB_01877,iECDH10B_1368.ECDH10B_2053,iECDH1ME8569_1439.ECDH1ME8569_1852,iECD_1391.ECD_01877,iECED1_1282.ECED1_2177,iECH74115_1262.ECH74115_2684,iECIAI1_1343.ECIAI1_1996,iECIAI39_1322.ECIAI39_1143,iECNA114_1301.ECNA114_2003,iECO103_1326.ECO103_2168,iECO111_1330.ECO111_2492,iECO26_1355.ECO26_2804,iECOK1_1307.ECOK1_2029,iECP_1309.ECP_1852,iECS88_1305.ECS88_1966,iECSF_1327.ECSF_1764,iECSP_1301.ECSP_2516,iECUMN_1333.ECUMN_2204,iECs_1301.ECs2650,iETEC_1333.ETEC_2020,iEcDH1_1363.EcDH1_1734,iEcE24377_1341.EcE24377A_2145,iEcHS_1320.EcHS_A2010,iEcSMS35_1347.EcSMS35_1271,iEcolC_1368.EcolC_1727,iG2583_1286.G2583_2363,iJO1366.b1912,iJR904.b1912,iLF82_1304.LF82_1635,iNRG857_1313.NRG857_09550,iSDY_1059.SDY_1106,iSSON_1240.SSON_1206,iSbBS512_1146.SbBS512_E1039,iUMN146_1321.UM146_07620,iUMNK88_1353.UMNK88_2386,iUTI89_1310.UTI89_C2113,iY75_1357.Y75_RS10025,iYL1228.KPN_02410,iZ_1308.Z3000,ic_1306.c2325	CDP-OH_P_transf
HKD2_k127_7839252_67	1094715.CM001373_gene2016	1.551e-09	61.0	2APXH@1|root,31F27@2|Bacteria,1QCFC@1224|Proteobacteria,1T85P@1236|Gammaproteobacteria,1JGAF@118969|Legionellales	118969|Legionellales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7903244_11	95619.PM1_0214240	2.512e-24	114.0	COG2207@1|root,COG2207@2|Bacteria,1Q3UX@1224|Proteobacteria,1RS88@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	transcriptional regulator	eutR	GO:0003674,GO:0003824,GO:0006081,GO:0006082,GO:0006089,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009059,GO:0009438,GO:0009987,GO:0010467,GO:0016053,GO:0016070,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019172,GO:0019243,GO:0019249,GO:0019438,GO:0019752,GO:0032774,GO:0032787,GO:0034641,GO:0034645,GO:0034654,GO:0042180,GO:0042182,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0046185,GO:0046394,GO:0046483,GO:0051596,GO:0061727,GO:0071704,GO:0072330,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901575,GO:1901576,GO:1901615,GO:1901617	-	ko:K04033	-	-	-	-	ko00000,ko03000	-	-	-	HTH_18
HKD2_k127_7903244_4	1168065.DOK_13459	2.347e-151	495.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,1RMBQ@1236|Gammaproteobacteria,1J4MS@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	COG1012 NAD-dependent aldehyde dehydrogenases	-	-	-	-	-	-	-	-	-	-	-	-	Aldedh
HKD2_k127_7903244_8	1168065.DOK_13464	5.115e-90	330.0	COG1454@1|root,COG1454@2|Bacteria,1NU28@1224|Proteobacteria,1SKCS@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	alcohol dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Fe-ADH
HKD2_k127_7903244_0	1144312.PMI09_04862	0.0	1226.0	COG3119@1|root,COG3119@2|Bacteria,1MV92@1224|Proteobacteria,2TTXG@28211|Alphaproteobacteria,4B9AV@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	Sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
HKD2_k127_7903244_9	379731.PST_0613	1.615e-87	301.0	COG2207@1|root,COG2207@2|Bacteria,1MX23@1224|Proteobacteria,1RN7K@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Arabinose_bd,HTH_18
HKD2_k127_7903244_7	379731.PST_0608	6.374e-98	330.0	COG1024@1|root,COG1024@2|Bacteria,1MWZC@1224|Proteobacteria,1RPSX@1236|Gammaproteobacteria,1Z1QJ@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
HKD2_k127_7903244_1	379731.PST_0607	1.339e-183	582.0	COG0183@1|root,COG0183@2|Bacteria,1MUZV@1224|Proteobacteria,1RN81@1236|Gammaproteobacteria,1Z3JW@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	I	COG0183 Acetyl-CoA acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7903244_3	379731.PST_0606	1.772e-178	565.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,1RMMJ@1236|Gammaproteobacteria,1Z1TD@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	I	COG1960 Acyl-CoA dehydrogenases	-	-	-	ko:K18244	-	-	-	-	ko00000,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HKD2_k127_7903244_6	379731.PST_0605	4.365e-107	353.0	COG1028@1|root,COG1028@2|Bacteria,1MUBQ@1224|Proteobacteria,1RQJT@1236|Gammaproteobacteria,1Z274@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	hadH2	-	-	-	-	-	-	-	-	-	-	-	adh_short,adh_short_C2
HKD2_k127_7903244_2	379731.PST_0604	3.06e-179	575.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,1S1XU@1236|Gammaproteobacteria	1236|Gammaproteobacteria	IQ	AMP-binding enzyme C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
HKD2_k127_7903244_10	948106.AWZT01000063_gene4075	2.759e-62	226.0	COG0657@1|root,COG0657@2|Bacteria,1RD8A@1224|Proteobacteria,2VVNG@28216|Betaproteobacteria,1K21M@119060|Burkholderiaceae	28216|Betaproteobacteria	I	Alpha beta hydrolase	-	-	3.1.1.83	ko:K14731	ko00903,ko00930,ko01220,map00903,map00930,map01220	-	R03751,R06390,R06391,R06392,R06393	RC00713,RC00983,RC01505	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_3
HKD2_k127_7903244_5	1121937.AUHJ01000023_gene191	8.933e-120	414.0	COG1020@1|root,COG1020@2|Bacteria,1N7HY@1224|Proteobacteria,1RZG3@1236|Gammaproteobacteria,466R7@72275|Alteromonadaceae	1236|Gammaproteobacteria	Q	Protein of unknown function (DUF1298)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1298,WES_acyltransf
HKD2_k127_79035_34	935548.KI912159_gene4393	7.059e-39	150.0	COG0001@1|root,COG0001@2|Bacteria,1MUY5@1224|Proteobacteria,2TT6G@28211|Alphaproteobacteria,43J9D@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	H	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
HKD2_k127_79035_8	1121918.ARWE01000001_gene2336	8.956e-123	410.0	COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,42MXN@68525|delta/epsilon subdivisions,2WJN0@28221|Deltaproteobacteria,43T7B@69541|Desulfuromonadales	28221|Deltaproteobacteria	EH	Anthranilate synthase component I, N terminal region	trpE	-	4.1.3.27	ko:K01657,ko:K13503	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
HKD2_k127_79035_22	429009.Adeg_1161	2.47e-70	251.0	COG0512@1|root,COG0512@2|Bacteria,1TT9R@1239|Firmicutes,24FR0@186801|Clostridia,42G1H@68295|Thermoanaerobacterales	186801|Clostridia	EH	TIGRFAM glutamine amidotransferase of anthranilate synthase	trpG	-	2.6.1.85,4.1.3.27	ko:K01658,ko:K01664	ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986,R01716	RC00010,RC01418,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
HKD2_k127_79035_20	1211115.ALIQ01000208_gene3361	9.845e-73	257.0	COG0547@1|root,COG0547@2|Bacteria,1MUPV@1224|Proteobacteria,2TR8S@28211|Alphaproteobacteria,3NA89@45404|Beijerinckiaceae	28211|Alphaproteobacteria	E	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)	trpD	GO:0000162,GO:0003674,GO:0003824,GO:0004048,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.4.2.18,4.1.3.27	ko:K00766,ko:K13497	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R00985,R00986,R01073	RC00010,RC00440,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3
HKD2_k127_79035_33	1122609.AUGT01000012_gene4354	1.402e-40	166.0	COG0134@1|root,COG0134@2|Bacteria,2GIVV@201174|Actinobacteria,4DNTB@85009|Propionibacteriales	201174|Actinobacteria	E	Indole-3-glycerol phosphate synthase	trpC	GO:0000162,GO:0000287,GO:0003674,GO:0003824,GO:0004425,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016020,GO:0016053,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019752,GO:0030312,GO:0034641,GO:0040007,GO:0042401,GO:0042430,GO:0042435,GO:0043167,GO:0043169,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046219,GO:0046391,GO:0046394,GO:0046483,GO:0046872,GO:0071704,GO:0071944,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.1.1.48	ko:K01609	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03508	RC00944	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPS
HKD2_k127_79035_36	1068978.AMETH_4371	1.075e-28	123.0	COG0135@1|root,COG0135@2|Bacteria,2IHPP@201174|Actinobacteria,4E306@85010|Pseudonocardiales	201174|Actinobacteria	E	N-(5'phosphoribosyl)anthranilate (PRA) isomerase	trpF	-	5.3.1.24	ko:K01817	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03509	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	PRAI
HKD2_k127_79035_6	572477.Alvin_1601	1.392e-140	466.0	COG0133@1|root,COG0133@2|Bacteria,1MUS8@1224|Proteobacteria,1RP4D@1236|Gammaproteobacteria,1WW9F@135613|Chromatiales	135613|Chromatiales	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB	-	4.2.1.20	ko:K01696	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HKD2_k127_79035_29	207559.Dde_3478	7.559e-53	197.0	COG0159@1|root,COG0159@2|Bacteria,1MXJV@1224|Proteobacteria,42N5B@68525|delta/epsilon subdivisions,2WJX4@28221|Deltaproteobacteria,2M9V0@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate	trpA	-	4.2.1.20	ko:K01695	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_syntA
HKD2_k127_79035_27	1238182.C882_2913	4.834e-57	205.0	COG1611@1|root,COG1611@2|Bacteria,1RD59@1224|Proteobacteria,2U5DP@28211|Alphaproteobacteria,2JSHV@204441|Rhodospirillales	204441|Rhodospirillales	S	Belongs to the LOG family	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
HKD2_k127_79035_15	391615.ABSJ01000026_gene121	3.588e-92	316.0	2CIBN@1|root,2Z8JT@2|Bacteria,1R902@1224|Proteobacteria,1RXPM@1236|Gammaproteobacteria,1J8X1@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_79035_12	395494.Galf_0140	2.326e-108	361.0	COG0708@1|root,COG0708@2|Bacteria,1MVII@1224|Proteobacteria,2VH7N@28216|Betaproteobacteria,44VA6@713636|Nitrosomonadales	28216|Betaproteobacteria	L	Endonuclease/Exonuclease/phosphatase family	xthA	-	3.1.11.2	ko:K01142	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exo_endo_phos
HKD2_k127_79035_1	472759.Nhal_0455	7.949e-263	825.0	COG0339@1|root,COG0339@2|Bacteria,1MU1K@1224|Proteobacteria,1RMAH@1236|Gammaproteobacteria,1WW1J@135613|Chromatiales	135613|Chromatiales	E	PFAM peptidase M3A and M3B, thimet oligopeptidase F	-	-	3.4.24.70	ko:K01414	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3
HKD2_k127_79035_30	1123279.ATUS01000001_gene1490	6.322e-52	196.0	COG1704@1|root,COG1704@2|Bacteria,1RDUH@1224|Proteobacteria,1S2KR@1236|Gammaproteobacteria,1J6CD@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	E3 Ubiquitin ligase	-	-	-	-	-	-	-	-	-	-	-	-	GIDE
HKD2_k127_79035_24	765912.Thimo_3302	5.5e-68	237.0	COG1704@1|root,COG1704@2|Bacteria,1R9YG@1224|Proteobacteria,1T06D@1236|Gammaproteobacteria,1X2KZ@135613|Chromatiales	135613|Chromatiales	S	LemA family	-	-	-	ko:K03744	-	-	-	-	ko00000	-	-	-	LemA
HKD2_k127_79035_18	349521.HCH_00037	1.643e-85	291.0	COG0169@1|root,COG0169@2|Bacteria,1MVH4@1224|Proteobacteria,1RPB7@1236|Gammaproteobacteria,1XHB7@135619|Oceanospirillales	135619|Oceanospirillales	E	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)	aroE	-	1.1.1.25	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413	RC00206	ko00000,ko00001,ko00002,ko01000	-	-	-	Shikimate_DH,Shikimate_dh_N
HKD2_k127_79035_4	765912.Thimo_0133	8.491e-167	531.0	COG0113@1|root,COG0113@2|Bacteria,1MWMW@1224|Proteobacteria,1RP6Q@1236|Gammaproteobacteria,1WW00@135613|Chromatiales	135613|Chromatiales	H	Belongs to the ALAD family	-	-	4.2.1.24	ko:K01698	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00036	RC00918,RC01781	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ALAD
HKD2_k127_79035_35	1120953.AUBH01000003_gene1907	1.655e-33	143.0	COG1595@1|root,COG1595@2|Bacteria,1R9ZN@1224|Proteobacteria,1S27W@1236|Gammaproteobacteria,466M0@72275|Alteromonadaceae	1236|Gammaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	sigV	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD2_k127_79035_41	1163407.UU7_15505	2.391e-13	80.0	COG5662@1|root,COG5662@2|Bacteria	2|Bacteria	K	AntiSigma factor	-	-	-	-	-	-	-	-	-	-	-	-	DUF3379
HKD2_k127_79035_19	1121104.AQXH01000003_gene309	1.18e-79	271.0	COG2818@1|root,COG2818@2|Bacteria,4NGRC@976|Bacteroidetes,1IQSX@117747|Sphingobacteriia	976|Bacteroidetes	L	DNA-3-methyladenine glycosylase	tag	-	3.2.2.20	ko:K01246	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Adenine_glyco
HKD2_k127_79035_17	765698.Mesci_4725	8.761e-86	292.0	COG2961@1|root,COG2961@2|Bacteria,1MWGA@1224|Proteobacteria,2TU5K@28211|Alphaproteobacteria,43H7F@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Specifically methylates the adenine in position 2030 of 23S rRNA	rlmJ	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0008988,GO:0009451,GO:0009987,GO:0010467,GO:0015976,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036307,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.266	ko:K07115	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	RsmJ
HKD2_k127_79035_10	1254432.SCE1572_16865	3.923e-120	412.0	COG1404@1|root,COG1404@2|Bacteria,1RDZC@1224|Proteobacteria	1224|Proteobacteria	O	serine protease protein	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
HKD2_k127_79035_5	396588.Tgr7_0116	3.095e-154	491.0	COG0408@1|root,COG0408@2|Bacteria,1MWMF@1224|Proteobacteria,1RMM8@1236|Gammaproteobacteria,1WX13@135613|Chromatiales	135613|Chromatiales	H	Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX	hemF	GO:0003674,GO:0005488,GO:0005515,GO:0042802,GO:0042803,GO:0046983	1.3.3.3	ko:K00228	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03220	RC00884	ko00000,ko00001,ko00002,ko01000	-	-	-	Coprogen_oxidas
HKD2_k127_79035_0	396588.Tgr7_0191	7.7e-321	1004.0	COG0550@1|root,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,1RNZ2@1236|Gammaproteobacteria,1WWWP@135613|Chromatiales	135613|Chromatiales	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topo_Zn_Ribbon,Topoisom_bac,Toprim,Toprim_C_rpt,zf-C4_Topoisom
HKD2_k127_79035_32	1286106.MPL1_00747	4.773e-44	168.0	COG2922@1|root,COG2922@2|Bacteria,1RD5F@1224|Proteobacteria,1S43X@1236|Gammaproteobacteria,4612G@72273|Thiotrichales	72273|Thiotrichales	S	Belongs to the Smg family	smg	-	-	ko:K03747	-	-	-	-	ko00000	-	-	-	DUF494
HKD2_k127_79035_14	243233.MCA2841	1.143e-96	328.0	COG0758@1|root,COG0758@2|Bacteria,1MVF6@1224|Proteobacteria,1RPJE@1236|Gammaproteobacteria,1XE4B@135618|Methylococcales	135618|Methylococcales	L	PFAM DNA recombination-mediator protein A	-	-	-	ko:K04096	-	-	-	-	ko00000	-	-	-	DNA_processg_A
HKD2_k127_79035_21	519989.ECTPHS_01149	1.108e-70	255.0	COG1652@1|root,COG1652@2|Bacteria,1MUBV@1224|Proteobacteria,1RPMB@1236|Gammaproteobacteria,1WWDN@135613|Chromatiales	135613|Chromatiales	S	PFAM Peptidoglycan-binding lysin domain	-	-	-	-	-	-	-	-	-	-	-	-	LysM
HKD2_k127_79035_23	765910.MARPU_04205	1.062e-68	238.0	COG0242@1|root,COG0242@2|Bacteria,1RA2P@1224|Proteobacteria,1S247@1236|Gammaproteobacteria,1WXF4@135613|Chromatiales	135613|Chromatiales	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions	def	-	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	Pep_deformylase
HKD2_k127_79035_13	765912.Thimo_1246	2.178e-104	357.0	COG0223@1|root,COG0223@2|Bacteria,1MU4Q@1224|Proteobacteria,1RP1T@1236|Gammaproteobacteria,1WWQE@135613|Chromatiales	135613|Chromatiales	J	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus	fmt	-	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	-	Formyl_trans_C,Formyl_trans_N
HKD2_k127_79035_11	396595.TK90_2271	2.051e-112	377.0	COG0144@1|root,COG0144@2|Bacteria,1MWPE@1224|Proteobacteria,1RN8X@1236|Gammaproteobacteria,1WVWG@135613|Chromatiales	135613|Chromatiales	J	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA	-	-	2.1.1.176	ko:K03500	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltr_RsmB-F,Methyltr_RsmF_N,NusB
HKD2_k127_79035_38	713586.KB900536_gene2227	2.77e-26	115.0	29CX4@1|root,2ZZV8@2|Bacteria,1RFY7@1224|Proteobacteria,1SBT1@1236|Gammaproteobacteria,1WYAZ@135613|Chromatiales	135613|Chromatiales	S	Domain of unknown function (DUF4390)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4390
HKD2_k127_79035_3	187272.Mlg_2624	4.726e-185	606.0	COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,1RQ8B@1236|Gammaproteobacteria,1WXE6@135613|Chromatiales	135613|Chromatiales	T	signal transduction histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS_4,PAS_8
HKD2_k127_79035_7	765913.ThidrDRAFT_0380	3.281e-133	438.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RRXX@1236|Gammaproteobacteria,1WXC2@135613|Chromatiales	135613|Chromatiales	T	response regulator receiver	-	-	-	ko:K13599	ko02020,map02020	M00498	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD2_k127_79035_42	1144305.PMI02_04498	4.035e-13	77.0	2C852@1|root,32YB2@2|Bacteria,1RH28@1224|Proteobacteria,2UG74@28211|Alphaproteobacteria,2K7DU@204457|Sphingomonadales	204457|Sphingomonadales	S	Domain of unknown function (DUF4136)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4136
HKD2_k127_79035_37	1500894.JQNN01000001_gene3707	2.229e-28	122.0	COG3245@1|root,COG3245@2|Bacteria,1MZBZ@1224|Proteobacteria,2VMBB@28216|Betaproteobacteria,476ER@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
HKD2_k127_79035_43	1150469.RSPPHO_02781	1.716e-08	58.0	COG2165@1|root,COG2165@2|Bacteria,1PJ5F@1224|Proteobacteria,2VC7I@28211|Alphaproteobacteria,2JY2W@204441|Rhodospirillales	204441|Rhodospirillales	NU	general secretion pathway protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_79035_28	643562.Daes_1424	5.277e-54	194.0	COG0454@1|root,COG0454@2|Bacteria,1QVMZ@1224|Proteobacteria	1224|Proteobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10
HKD2_k127_79035_9	1163617.SCD_n00016	6.404e-122	397.0	COG1432@1|root,COG1432@2|Bacteria,1MX5C@1224|Proteobacteria,2VK44@28216|Betaproteobacteria	28216|Betaproteobacteria	NU	NYN domain	-	-	-	-	-	-	-	-	-	-	-	-	NYN,OST-HTH
HKD2_k127_79035_16	269796.Rru_A1883	1.131e-90	308.0	COG0598@1|root,COG0598@2|Bacteria,1MWMP@1224|Proteobacteria,2TQQD@28211|Alphaproteobacteria,2JQ7P@204441|Rhodospirillales	204441|Rhodospirillales	P	Mediates influx of magnesium ions	corA	-	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
HKD2_k127_79035_31	697282.Mettu_2182	9.479e-49	182.0	COG1651@1|root,COG1651@2|Bacteria,1RGWH@1224|Proteobacteria,1S5WA@1236|Gammaproteobacteria,1XEWA@135618|Methylococcales	135618|Methylococcales	O	Thiol disulfide interchange protein	dsbA	-	-	ko:K03673	ko01503,map01503	M00728	-	-	ko00000,ko00001,ko00002,ko03110	-	-	-	DSBA
HKD2_k127_79035_25	1123400.KB904754_gene1017	3.558e-58	209.0	COG2863@1|root,COG2863@2|Bacteria,1N2NB@1224|Proteobacteria,1RZFP@1236|Gammaproteobacteria,460ST@72273|Thiotrichales	72273|Thiotrichales	C	PFAM cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,Cytochrome_CBB3
HKD2_k127_79035_26	396588.Tgr7_0088	1.593e-57	207.0	COG0218@1|root,COG0218@2|Bacteria,1MY3Z@1224|Proteobacteria,1RNJP@1236|Gammaproteobacteria,1WWX9@135613|Chromatiales	135613|Chromatiales	D	Necessary for normal cell division and for the maintenance of normal septation	engB	-	-	ko:K03978	-	-	-	-	ko00000,ko03036	-	-	-	MMR_HSR1
HKD2_k127_79035_39	1385517.N800_09005	9.675e-23	106.0	COG3637@1|root,COG3637@2|Bacteria,1N3BJ@1224|Proteobacteria,1SFEZ@1236|Gammaproteobacteria,1X923@135614|Xanthomonadales	135614|Xanthomonadales	M	OmpA-like transmembrane domain	-	-	-	-	-	-	-	-	-	-	-	-	OMP_b-brl
HKD2_k127_79035_40	1385517.N800_09005	5.65e-22	102.0	COG3637@1|root,COG3637@2|Bacteria,1N3BJ@1224|Proteobacteria,1SFEZ@1236|Gammaproteobacteria,1X923@135614|Xanthomonadales	135614|Xanthomonadales	M	OmpA-like transmembrane domain	-	-	-	-	-	-	-	-	-	-	-	-	OMP_b-brl
HKD2_k127_79035_2	697282.Mettu_2187	3.409e-254	795.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,1RNBG@1236|Gammaproteobacteria,1XEFJ@135618|Methylococcales	135618|Methylococcales	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
HKD2_k127_7926387_3	1248760.ANFZ01000012_gene41	5.986e-32	136.0	2BFHU@1|root,329BM@2|Bacteria,1RFVJ@1224|Proteobacteria,2U8MF@28211|Alphaproteobacteria,2K1CV@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7926387_1	247639.MGP2080_08129	1.33e-88	302.0	COG0596@1|root,COG0596@2|Bacteria	2|Bacteria	S	hydrolase activity, acting on ester bonds	-	-	3.1.1.24	ko:K01055	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00568	R02991	RC00825	ko00000,ko00001,ko00002,ko01000	-	-	-	Abhydrolase_1
HKD2_k127_7926387_2	1121861.KB899911_gene1358	4.387e-65	229.0	COG1335@1|root,COG1335@2|Bacteria,1MZUV@1224|Proteobacteria,2U0TK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	isochorismatase	-	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
HKD2_k127_7926387_0	247639.MGP2080_08144	4.525e-156	497.0	COG0146@1|root,COG0146@2|Bacteria,1QU46@1224|Proteobacteria,1T2DW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	EQ	COG0146 N-methylhydantoinase B acetone carboxylase, alpha subunit	hyuB	-	3.5.2.14	ko:K01474	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydantoinase_B
HKD2_k127_7962734_0	1157634.KB912954_gene5818	1.94e-229	719.0	COG1960@1|root,COG1960@2|Bacteria,2GJIB@201174|Actinobacteria	201174|Actinobacteria	I	acyl-CoA dehydrogenase	-	-	1.3.8.1	ko:K00248	ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212	-	R01175,R01178,R02661,R03172,R04751	RC00052,RC00068,RC00076,RC00120,RC00148	ko00000,ko00001,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N
HKD2_k127_7962734_13	264198.Reut_B5250	5.158e-21	105.0	COG0583@1|root,COG0583@2|Bacteria,1RJXD@1224|Proteobacteria,2WEM8@28216|Betaproteobacteria,1KHS1@119060|Burkholderiaceae	28216|Betaproteobacteria	K	LysR substrate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HKD2_k127_7962734_3	1242864.D187_002585	8.742e-181	578.0	COG2304@1|root,COG2304@2|Bacteria,1R8EZ@1224|Proteobacteria,433AE@68525|delta/epsilon subdivisions,2WYFQ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	IgA Peptidase M64	-	-	-	-	-	-	-	-	-	-	-	-	M64_N,Peptidase_M64
HKD2_k127_7962734_5	1123053.AUDG01000081_gene3061	9.674e-102	345.0	COG3174@1|root,COG3174@2|Bacteria,1NDBI@1224|Proteobacteria,1RRGY@1236|Gammaproteobacteria,1WVVW@135613|Chromatiales	135613|Chromatiales	S	Domain of unknown function (DUF4010)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4010,MgtC
HKD2_k127_7962734_12	926560.KE387023_gene3760	2.143e-33	136.0	COG2133@1|root,COG2133@2|Bacteria	2|Bacteria	G	pyrroloquinoline quinone binding	-	-	-	-	-	-	-	-	-	-	-	-	CHRD,Malectin
HKD2_k127_7962734_4	1415780.JPOG01000001_gene2958	6.014e-136	437.0	COG2159@1|root,COG2159@2|Bacteria,1MUUR@1224|Proteobacteria,1S1Y6@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	amidohydrolase	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
HKD2_k127_7962734_6	383381.EH30_15640	7.07e-91	306.0	COG1028@1|root,COG1028@2|Bacteria,1NB6S@1224|Proteobacteria,2U1XH@28211|Alphaproteobacteria,2K20C@204457|Sphingomonadales	204457|Sphingomonadales	IQ	Short-chain dehydrogenase reductase sdr	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HKD2_k127_7962734_9	383381.EH30_15680	7.698e-45	168.0	COG0346@1|root,COG0346@2|Bacteria,1RKHN@1224|Proteobacteria,2UBJ1@28211|Alphaproteobacteria,2K57E@204457|Sphingomonadales	204457|Sphingomonadales	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase_4
HKD2_k127_7962734_2	392499.Swit_1323	7.52e-186	600.0	COG1520@1|root,COG2010@1|root,COG1520@2|Bacteria,COG2010@2|Bacteria,1PIDE@1224|Proteobacteria,2TTS3@28211|Alphaproteobacteria,2K3QU@204457|Sphingomonadales	204457|Sphingomonadales	C	PQQ-like domain	-	-	1.1.2.6	ko:K05889	-	-	R03136	-	ko00000,ko01000	-	-	-	Cytochrome_CBB3,PQQ,PQQ_2,PQQ_3
HKD2_k127_7962734_10	1411123.JQNH01000001_gene2788	1.083e-40	156.0	COG0346@1|root,COG0346@2|Bacteria,1MWHG@1224|Proteobacteria,2U1WR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase_4
HKD2_k127_7962734_1	1030157.AFMP01000026_gene1053	1.422e-192	619.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2TR2W@28211|Alphaproteobacteria,2K2MS@204457|Sphingomonadales	204457|Sphingomonadales	IQ	AMP-dependent synthetase and ligase	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
HKD2_k127_7962734_8	565045.NOR51B_1610	7.263e-77	264.0	COG4319@1|root,COG4319@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_4
HKD2_k127_7962734_7	1123073.KB899245_gene112	1.027e-88	315.0	COG0457@1|root,COG0457@2|Bacteria,1MVMG@1224|Proteobacteria,1RNVA@1236|Gammaproteobacteria,1X6C3@135614|Xanthomonadales	135614|Xanthomonadales	S	Putative 2OG-Fe(II) oxygenase	-	-	-	-	-	-	-	-	-	-	-	-	2OG-FeII_Oxy_5,TPR_16,TPR_19
HKD2_k127_7962734_11	1221522.B723_10880	2.451e-34	143.0	COG1853@1|root,COG1853@2|Bacteria,1RGYM@1224|Proteobacteria,1RSQV@1236|Gammaproteobacteria,1YRD7@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	K	Flavin reductase like domain	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
HKD2_k127_7982594_0	1000565.METUNv1_00688	2.445e-118	398.0	COG0175@1|root,COG0175@2|Bacteria,1MUCZ@1224|Proteobacteria,2VJH9@28216|Betaproteobacteria,2KVVW@206389|Rhodocyclales	206389|Rhodocyclales	H	COG0175 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase) FAD synthetase and related enzymes	cysD	-	2.7.7.4	ko:K00957	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00529,R04929	RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	PAPS_reduct
HKD2_k127_7982594_1	1469245.JFBG01000094_gene1658	3.365e-99	330.0	COG0604@1|root,COG0604@2|Bacteria,1MV3W@1224|Proteobacteria,1RMHG@1236|Gammaproteobacteria,1WX3U@135613|Chromatiales	135613|Chromatiales	C	PFAM Alcohol dehydrogenase	-	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
HKD2_k127_7998109_3	748247.AZKH_1917	5.506e-66	231.0	COG2828@1|root,COG2828@2|Bacteria,1MXVV@1224|Proteobacteria,2VJAW@28216|Betaproteobacteria	28216|Betaproteobacteria	S	AcnD-accessory protein PrpF	-	-	-	-	-	-	-	-	-	-	-	-	PrpF
HKD2_k127_7998109_0	398767.Glov_3541	2.744e-145	482.0	COG1053@1|root,COG1053@2|Bacteria,1MX5A@1224|Proteobacteria,42P4Z@68525|delta/epsilon subdivisions,2WK24@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM fumarate reductase succinate dehydrogenase flavoprotein domain protein	-	-	1.3.5.4	ko:K00244	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020	M00009,M00011,M00150,M00173	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytochrom_c3_2,FAD_binding_2
HKD2_k127_7998109_7	290397.Adeh_2097	1.501e-14	79.0	COG3005@1|root,COG3005@2|Bacteria	2|Bacteria	C	denitrification pathway	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C552,Cytochrom_c3_2,Paired_CXXCH_1
HKD2_k127_7998109_4	1479238.JQMZ01000001_gene2538	1.505e-64	227.0	COG1309@1|root,COG1309@2|Bacteria,1R7YG@1224|Proteobacteria,2U3ZJ@28211|Alphaproteobacteria,440Y9@69657|Hyphomonadaceae	28211|Alphaproteobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	ko:K16137	-	-	-	-	ko00000,ko03000	-	-	-	TetR_N
HKD2_k127_7998109_6	983917.RGE_09750	9.212e-44	172.0	COG5507@1|root,COG5507@2|Bacteria,1RHC1@1224|Proteobacteria,2VSZQ@28216|Betaproteobacteria,1KMDC@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Protein of unknown function (DUF1428)	ybaA	-	-	-	-	-	-	-	-	-	-	-	DUF1428
HKD2_k127_7998109_1	1096930.L284_13620	7.296e-97	324.0	COG3324@1|root,COG3324@2|Bacteria,1R81W@1224|Proteobacteria,2U6BE@28211|Alphaproteobacteria,2K4NC@204457|Sphingomonadales	204457|Sphingomonadales	S	enzyme related to lactoylglutathione lyase	-	-	-	ko:K06996	-	-	-	-	ko00000	-	-	-	Glyoxalase
HKD2_k127_7998109_2	1121939.L861_01520	2.859e-76	260.0	COG3865@1|root,COG3865@2|Bacteria,1N7IY@1224|Proteobacteria,1S25M@1236|Gammaproteobacteria,1XNFA@135619|Oceanospirillales	135619|Oceanospirillales	S	3-demethylubiquinone-9 3-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	3-dmu-9_3-mt
HKD2_k127_7998109_5	1158292.JPOE01000002_gene2108	1.606e-53	201.0	COG1309@1|root,COG1309@2|Bacteria,1RDE7@1224|Proteobacteria,2VRUC@28216|Betaproteobacteria	28216|Betaproteobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
HKD2_k127_8008678_0	28229.ND2E_4035	1.765e-106	358.0	COG3503@1|root,COG3503@2|Bacteria,1QQ9D@1224|Proteobacteria,1RMPY@1236|Gammaproteobacteria,2Q800@267889|Colwelliaceae	1236|Gammaproteobacteria	S	Protein of unknown function (DUF1624)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1624
HKD2_k127_8008678_1	1449049.JONW01000005_gene1181	9.203e-103	341.0	COG1180@1|root,COG1180@2|Bacteria,1NQC1@1224|Proteobacteria,2TV8Y@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
HKD2_k127_8008678_2	1449049.JONW01000005_gene1182	2.333e-93	308.0	COG1882@1|root,COG1882@2|Bacteria,1MWBF@1224|Proteobacteria,2TT7K@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	formate C-acetyltransferase glycine radical	-	-	2.3.1.54	ko:K00656	ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120	-	R00212,R06987	RC00004,RC01181,RC02742,RC02833	ko00000,ko00001,ko01000	-	-	-	Gly_radical,PFL-like
HKD2_k127_8067591_2	1123256.KB907925_gene1159	1.031e-28	124.0	COG2968@1|root,COG2968@2|Bacteria,1RH7T@1224|Proteobacteria,1RP7T@1236|Gammaproteobacteria,1X8DI@135614|Xanthomonadales	135614|Xanthomonadales	S	Protein of unknown function (DUF541)	-	-	-	-	-	-	-	-	-	-	-	-	SIMPL
HKD2_k127_8067591_0	391615.ABSJ01000033_gene698	4.175e-45	170.0	COG2863@1|root,COG2863@2|Bacteria,1MZU1@1224|Proteobacteria,1SBJR@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	cytochrome	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C
HKD2_k127_8067591_1	215803.DB30_7910	2.828e-35	137.0	COG0491@1|root,COG0491@2|Bacteria,1MXKX@1224|Proteobacteria,42R8E@68525|delta/epsilon subdivisions,2WN6V@28221|Deltaproteobacteria,2YZHF@29|Myxococcales	28221|Deltaproteobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HKD2_k127_8259699_5	331869.BAL199_10250	5.671e-26	112.0	COG0477@1|root,COG2814@2|Bacteria,1MW19@1224|Proteobacteria,2TRQD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EGP	COG0477 Permeases of the major facilitator superfamily	-	-	-	ko:K07552	-	-	-	-	ko00000,ko02000	2.A.1.2	-	-	MFS_1
HKD2_k127_8259699_0	713586.KB900536_gene1208	1.271e-239	772.0	COG4191@1|root,COG5000@1|root,COG4191@2|Bacteria,COG5000@2|Bacteria,1RCM9@1224|Proteobacteria,1RP53@1236|Gammaproteobacteria,1WZX9@135613|Chromatiales	135613|Chromatiales	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg
HKD2_k127_8259699_2	1149133.ppKF707_1564	7.438e-88	296.0	COG0745@1|root,COG0745@2|Bacteria,1MY3D@1224|Proteobacteria,1RXE9@1236|Gammaproteobacteria,1YJ0W@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	T	Transcriptional regulatory protein, C terminal	-	-	-	ko:K07659	ko02020,ko02026,map02020,map02026	M00445,M00742,M00743	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
HKD2_k127_8259699_1	1207075.PputUW4_02087	1.255e-120	397.0	2CCCK@1|root,2Z7UH@2|Bacteria,1R3SV@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	AurF
HKD2_k127_8259699_3	1449048.JQKU01000008_gene929	3.462e-76	269.0	COG2020@1|root,COG2020@2|Bacteria,2GN9N@201174|Actinobacteria,2336J@1762|Mycobacteriaceae	201174|Actinobacteria	O	NnrU protein	-	-	2.1.1.334	ko:K21310	ko00920,map00920	-	R11546	RC02653	ko00000,ko00001,ko01000	-	-	-	NnrU
HKD2_k127_8259699_4	765912.Thimo_2346	2.105e-42	157.0	COG1993@1|root,COG1993@2|Bacteria,1RH30@1224|Proteobacteria,1SFPH@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Uncharacterized ACR, COG1993	-	-	-	-	-	-	-	-	-	-	-	-	DUF190
HKD2_k127_8311847_1	748247.AZKH_p0144	1.793e-215	677.0	COG5598@1|root,COG5598@2|Bacteria,1MWJN@1224|Proteobacteria	1224|Proteobacteria	H	trimethylamine methyltransferase	mttB2	-	2.1.1.250	ko:K14083	ko00680,ko01120,ko01200,map00680,map01120,map01200	M00563	R09124,R10016	RC00035,RC00732,RC01144,RC02984	ko00000,ko00001,ko00002,ko01000	-	-	-	MTTB
HKD2_k127_8311847_0	1090320.KB900605_gene2341	3.329e-299	950.0	COG1629@1|root,COG4771@2|Bacteria,1MWKN@1224|Proteobacteria,2UPQH@28211|Alphaproteobacteria,2KEDS@204457|Sphingomonadales	204457|Sphingomonadales	P	TonB dependent receptor	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
HKD2_k127_8311847_2	391165.GbCGDNIH1_0086	5.625e-91	306.0	COG4175@1|root,COG4175@2|Bacteria,1MU86@1224|Proteobacteria,2TS8Y@28211|Alphaproteobacteria,2JRC8@204441|Rhodospirillales	204441|Rhodospirillales	E	ATPases associated with a variety of cellular activities	-	-	3.6.3.32	ko:K02000	ko02010,map02010	M00208	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.12	-	-	ABC_tran
HKD2_k127_8369154_3	1279017.AQYJ01000028_gene2404	4.722e-158	522.0	COG4772@1|root,COG4772@2|Bacteria,1MUIH@1224|Proteobacteria,1RQYX@1236|Gammaproteobacteria,46D6R@72275|Alteromonadaceae	1236|Gammaproteobacteria	P	TonB dependent receptor	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
HKD2_k127_8369154_4	384676.PSEEN3920	2.85e-153	512.0	COG1752@1|root,COG4775@1|root,COG1752@2|Bacteria,COG4775@2|Bacteria,1MUM9@1224|Proteobacteria,1RRSK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	esterase of the alpha-beta hydrolase superfamily	plpD	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Bac_surface_Ag,POTRA,Patatin
HKD2_k127_8369154_18	765912.Thimo_2337	4.968e-08	57.0	2EFZ6@1|root,339RC@2|Bacteria,1P76P@1224|Proteobacteria,1SIDJ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8369154_7	1286631.X805_16290	3.351e-113	376.0	COG0604@1|root,COG0604@2|Bacteria,1MWRK@1224|Proteobacteria,2VJ1C@28216|Betaproteobacteria,1KJ8H@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Alcohol dehydrogenase GroES-like domain	-	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
HKD2_k127_8369154_10	1500893.JQNB01000001_gene1501	7.367e-62	230.0	COG0515@1|root,COG0515@2|Bacteria,1QVSB@1224|Proteobacteria,1SJ90@1236|Gammaproteobacteria,1XCXV@135614|Xanthomonadales	135614|Xanthomonadales	KLT	serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8369154_15	645512.GCWU000246_01782	1.007e-23	108.0	COG2020@1|root,COG2020@2|Bacteria,3TBYY@508458|Synergistetes	508458|Synergistetes	O	Phospholipid methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
HKD2_k127_8369154_11	1120999.JONM01000023_gene3200	5.881e-53	194.0	COG2095@1|root,COG2095@2|Bacteria,1MV1C@1224|Proteobacteria,2VKRW@28216|Betaproteobacteria,2KR9I@206351|Neisseriales	206351|Neisseriales	U	MarC family integral membrane protein	-	-	-	ko:K05595	-	-	-	-	ko00000,ko02000	2.A.95.1	-	-	MarC
HKD2_k127_8369154_9	1487953.JMKF01000025_gene2357	2.69e-101	334.0	COG0225@1|root,COG0225@2|Bacteria,1G1QF@1117|Cyanobacteria,1H72I@1150|Oscillatoriales	1117|Cyanobacteria	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	msrA	-	1.8.4.11	ko:K07304	-	-	-	-	ko00000,ko01000	-	-	-	PMSR
HKD2_k127_8369154_17	555793.WSK_3233	4.952e-10	65.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	-	-	-	ko:K00406	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002	3.D.4.3	-	-	Cytochrome_CBB3
HKD2_k127_8369154_2	1120705.FG95_03677	4.281e-194	618.0	COG0277@1|root,COG0277@2|Bacteria,1MY08@1224|Proteobacteria,2U5D5@28211|Alphaproteobacteria,2K1C7@204457|Sphingomonadales	204457|Sphingomonadales	C	Protein involved in UDP-N-acetylmuramate dehydrogenase activity and amino sugar metabolic process	-	-	1.17.99.1	ko:K05797	ko00623,ko01100,ko01120,map00623,map01100,map01120	-	R02675,R11194	RC00769	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
HKD2_k127_8369154_8	685778.AORL01000013_gene1998	3.046e-105	359.0	COG1228@1|root,COG1228@2|Bacteria,1R86X@1224|Proteobacteria,2U400@28211|Alphaproteobacteria,2K1TI@204457|Sphingomonadales	204457|Sphingomonadales	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
HKD2_k127_8369154_0	488538.SAR116_2173	0.0	1294.0	COG0404@1|root,COG0665@1|root,COG0404@2|Bacteria,COG0665@2|Bacteria,1MUXJ@1224|Proteobacteria,2TRGS@28211|Alphaproteobacteria,4BR7M@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	Belongs to the GcvT family	-	-	1.5.8.4	ko:K00315	ko00260,ko01100,map00260,map01100	-	R01565	RC00181	ko00000,ko00001,ko01000	-	-	-	DAO,FAO_M,GCV_T,GCV_T_C
HKD2_k127_8369154_1	909943.HIMB100_00014370	1.104e-214	680.0	COG5598@1|root,COG5598@2|Bacteria,1MWJN@1224|Proteobacteria,2TRAM@28211|Alphaproteobacteria,4BTAP@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	H	Trimethylamine methyltransferase (MTTB)	-	-	2.1.1.250	ko:K14083	ko00680,ko01120,ko01200,map00680,map01120,map01200	M00563	R09124,R10016	RC00035,RC00732,RC01144,RC02984	ko00000,ko00001,ko00002,ko01000	-	-	-	MTTB
HKD2_k127_8369154_13	1123261.AXDW01000004_gene2935	4.092e-49	181.0	COG3832@1|root,COG3832@2|Bacteria,1RDMX@1224|Proteobacteria,1S914@1236|Gammaproteobacteria,1XC1N@135614|Xanthomonadales	135614|Xanthomonadales	KT	Polyketide cyclase / dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	GyrI-like,Polyketide_cyc2
HKD2_k127_8369154_12	1384054.N790_03655	6.459e-53	198.0	COG2930@1|root,COG2930@2|Bacteria,1RHV6@1224|Proteobacteria,1SDNN@1236|Gammaproteobacteria,1X44C@135614|Xanthomonadales	135614|Xanthomonadales	S	Las17-binding protein actin regulator	-	-	-	-	-	-	-	-	-	-	-	-	Ysc84
HKD2_k127_8369154_16	46429.BV95_04084	4.024e-12	79.0	2ANEF@1|root,31DD2@2|Bacteria,1RHST@1224|Proteobacteria,2UA6U@28211|Alphaproteobacteria,2K5G6@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8369154_6	1131814.JAFO01000001_gene3088	1.729e-127	425.0	COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,2TUKZ@28211|Alphaproteobacteria,3F0TD@335928|Xanthobacteraceae	28211|Alphaproteobacteria	J	Amidase	MA20_19360	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
HKD2_k127_8369154_5	1458357.BG58_12495	2.288e-143	468.0	COG1804@1|root,COG1804@2|Bacteria,1PRUN@1224|Proteobacteria,2W94H@28216|Betaproteobacteria,1KCNE@119060|Burkholderiaceae	28216|Betaproteobacteria	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
HKD2_k127_8369154_14	338969.Rfer_4168	1.054e-43	163.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2VMYW@28216|Betaproteobacteria,4AGYA@80864|Comamonadaceae	28216|Betaproteobacteria	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
HKD2_k127_8371338_2	1123073.KB899242_gene1569	2.043e-26	114.0	COG0583@1|root,COG0583@2|Bacteria,1MWVU@1224|Proteobacteria,1RPT8@1236|Gammaproteobacteria,1X98Y@135614|Xanthomonadales	135614|Xanthomonadales	K	LysR substrate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HKD2_k127_8371338_1	1163617.SCD_n00303	4.221e-36	139.0	COG4633@1|root,COG4633@2|Bacteria,1N6VB@1224|Proteobacteria,2WHPH@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Cupredoxin-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupredoxin_1
HKD2_k127_8371338_0	1380394.JADL01000007_gene4476	1.33e-73	260.0	COG0672@1|root,COG0672@2|Bacteria,1MX1M@1224|Proteobacteria,2TU8Z@28211|Alphaproteobacteria,2JRT0@204441|Rhodospirillales	204441|Rhodospirillales	P	Iron permease FTR1 family	-	-	-	ko:K07243	-	-	-	-	ko00000,ko02000	2.A.108.1,2.A.108.2	-	-	FTR1
HKD2_k127_8405963_20	1276756.AUEX01000018_gene2971	3.664e-11	64.0	COG2360@1|root,COG2360@2|Bacteria,1R9W8@1224|Proteobacteria,2VIUV@28216|Betaproteobacteria,4AB8H@80864|Comamonadaceae	28216|Betaproteobacteria	O	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine	aat	-	2.3.2.6	ko:K00684	-	-	R03813,R11443,R11444	RC00055,RC00064	ko00000,ko01000	-	-	-	Leu_Phe_trans
HKD2_k127_8405963_16	1121940.AUDZ01000006_gene323	5.084e-35	135.0	COG0361@1|root,COG0361@2|Bacteria,1MZFU@1224|Proteobacteria,1S8WZ@1236|Gammaproteobacteria,1XKHQ@135619|Oceanospirillales	135619|Oceanospirillales	J	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex	infA	-	-	ko:K02518	-	-	-	-	ko00000,ko03012	-	-	-	eIF-1a
HKD2_k127_8405963_0	1123073.KB899244_gene328	0.0	1063.0	COG0542@1|root,COG0542@2|Bacteria,1MV8B@1224|Proteobacteria,1RMH3@1236|Gammaproteobacteria,1X3NX@135614|Xanthomonadales	135614|Xanthomonadales	O	ATPase and specificity subunit of the ClpA-ClpP ATP dependent serine protease	clpA	-	-	ko:K03694	-	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
HKD2_k127_8405963_14	396588.Tgr7_1839	2.229e-43	160.0	COG2127@1|root,COG2127@2|Bacteria,1MZU8@1224|Proteobacteria,1S8Z7@1236|Gammaproteobacteria,1WYBV@135613|Chromatiales	135613|Chromatiales	S	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation	clpS	-	-	ko:K06891	-	-	-	-	ko00000	-	-	-	ClpS
HKD2_k127_8405963_15	1123261.AXDW01000001_gene1409	1.92e-36	151.0	COG3031@1|root,COG3031@2|Bacteria,1RD3I@1224|Proteobacteria,1RQKA@1236|Gammaproteobacteria,1X6CK@135614|Xanthomonadales	135614|Xanthomonadales	U	Type II secretion system protein C	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,T2SSC
HKD2_k127_8405963_4	1033802.SSPSH_003278	3.82e-174	574.0	COG1450@1|root,COG1450@2|Bacteria,1MUUA@1224|Proteobacteria,1RPJS@1236|Gammaproteobacteria	1236|Gammaproteobacteria	NU	General Secretion Pathway protein	gspD	-	-	ko:K02453	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	Secretin,Secretin_N
HKD2_k127_8405963_1	713586.KB900536_gene2363	1.154e-202	645.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,1RMBS@1236|Gammaproteobacteria,1WX5F@135613|Chromatiales	135613|Chromatiales	NU	PFAM Type II secretion system protein E	-	-	-	ko:K02454	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSE,T2SSE_N
HKD2_k127_8405963_8	187272.Mlg_2392	3.376e-127	418.0	COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,1RQ86@1236|Gammaproteobacteria,1WXA3@135613|Chromatiales	135613|Chromatiales	U	General secretion pathway protein F	-	-	-	ko:K02455	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSF
HKD2_k127_8405963_17	519989.ECTPHS_00265	1.2e-30	125.0	COG1188@1|root,COG1188@2|Bacteria,1MZR6@1224|Proteobacteria,1S8VU@1236|Gammaproteobacteria,1WYI6@135613|Chromatiales	135613|Chromatiales	J	Belongs to the HSP15 family	-	-	-	ko:K04762	-	-	-	-	ko00000,ko03110	-	-	-	S4
HKD2_k127_8405963_3	1121459.AQXE01000008_gene912	2.448e-176	562.0	COG0156@1|root,COG0156@2|Bacteria,1MVVH@1224|Proteobacteria,42MM1@68525|delta/epsilon subdivisions,2WIU7@28221|Deltaproteobacteria,2MA8W@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide	kbl	-	2.3.1.29,2.3.1.47	ko:K00639,ko:K00652	ko00260,ko00780,ko01100,map00260,map00780,map01100	M00123,M00573,M00577	R00371,R03210,R10124	RC00004,RC00039,RC00394,RC02725	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2,BioW
HKD2_k127_8405963_2	291112.PAU_04351	1.442e-177	578.0	COG1063@1|root,COG1063@2|Bacteria,1MV9A@1224|Proteobacteria,1RMNY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Catalyzes the NAD( )-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate	tdh	GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006563,GO:0006564,GO:0006566,GO:0006567,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0008270,GO:0008652,GO:0008743,GO:0009056,GO:0009058,GO:0009063,GO:0009066,GO:0009068,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0030145,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046395,GO:0046870,GO:0046872,GO:0046914,GO:0055114,GO:0071704,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607	1.1.1.103	ko:K00060	ko00260,map00260	-	R01465	RC00525	ko00000,ko00001,ko01000	-	-	iEC042_1314.EC042_3926,iECUMN_1333.ECUMN_4133,iPC815.YPO0060	ADH_N,ADH_zinc_N
HKD2_k127_8405963_9	1123487.KB892834_gene2626	2.334e-118	388.0	COG1968@1|root,COG1968@2|Bacteria,1MX02@1224|Proteobacteria,2VHSA@28216|Betaproteobacteria,2KV15@206389|Rhodocyclales	206389|Rhodocyclales	V	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin	uppP	-	3.6.1.27	ko:K06153	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	BacA
HKD2_k127_8405963_6	1122603.ATVI01000005_gene3347	3.469e-145	482.0	COG0616@1|root,COG0616@2|Bacteria,1MUXE@1224|Proteobacteria,1RNYW@1236|Gammaproteobacteria,1X31T@135614|Xanthomonadales	135614|Xanthomonadales	OU	signal peptide peptidase	sppA	-	-	ko:K04773	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S49
HKD2_k127_8405963_11	519989.ECTPHS_00190	9.463e-51	181.0	COG0335@1|root,COG0335@2|Bacteria,1RH3A@1224|Proteobacteria,1S5XX@1236|Gammaproteobacteria,1WYID@135613|Chromatiales	135613|Chromatiales	J	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site	rplS	-	-	ko:K02884	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L19
HKD2_k127_8405963_10	1123368.AUIS01000030_gene1260	1.762e-90	304.0	COG0336@1|root,COG0336@2|Bacteria,1MUN1@1224|Proteobacteria,1RMWC@1236|Gammaproteobacteria,2NCQM@225057|Acidithiobacillales	225057|Acidithiobacillales	J	Belongs to the RNA methyltransferase TrmD family	trmD	-	2.1.1.228	ko:K00554	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	tRNA_m1G_MT
HKD2_k127_8405963_13	1492922.GY26_15310	3.416e-44	166.0	COG0806@1|root,COG0806@2|Bacteria,1MWQR@1224|Proteobacteria,1RNJ2@1236|Gammaproteobacteria,1J6R6@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes	rimM	GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0022607,GO:0022613,GO:0022618,GO:0030490,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:1901360	-	ko:K02860	-	-	-	-	ko00000,ko03009	-	-	-	PRC,RimM
HKD2_k127_8405963_19	2340.JV46_04240	1.515e-25	109.0	COG0228@1|root,COG0228@2|Bacteria,1MZCT@1224|Proteobacteria,1S8RT@1236|Gammaproteobacteria,1J6MP@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	Belongs to the bacterial ribosomal protein bS16 family	rpsP	GO:0000028,GO:0000217,GO:0000400,GO:0003674,GO:0003676,GO:0003677,GO:0003735,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006259,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016787,GO:0016788,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02959	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S16
HKD2_k127_8405963_5	519989.ECTPHS_00170	3.057e-169	543.0	COG0541@1|root,COG0541@2|Bacteria,1MVIA@1224|Proteobacteria,1RMU9@1236|Gammaproteobacteria,1WW6N@135613|Chromatiales	135613|Chromatiales	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components	ffh	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
HKD2_k127_8405963_12	1249627.D779_3295	3.161e-44	172.0	COG4137@1|root,COG4137@2|Bacteria,1R3YD@1224|Proteobacteria,1RPUQ@1236|Gammaproteobacteria,1WX1P@135613|Chromatiales	135613|Chromatiales	S	Cytochrome c assembly protein	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C_asm
HKD2_k127_8405963_7	765911.Thivi_0053	5.326e-145	471.0	COG4536@1|root,COG4536@2|Bacteria,1NZ99@1224|Proteobacteria,1RNCE@1236|Gammaproteobacteria,1WWQM@135613|Chromatiales	135613|Chromatiales	P	CBS domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
HKD2_k127_8405963_18	686578.AFFX01000011_gene2512	4.46e-26	108.0	COG1066@1|root,COG1066@2|Bacteria,1MUJQ@1224|Proteobacteria,1RN2E@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function	radA	GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363	-	ko:K04485	-	-	-	-	ko00000,ko03400	-	-	-	AAA_25,ATPase,ChlI
HKD2_k127_860661_4	1026882.MAMP_03107	1.383e-113	373.0	COG0206@1|root,COG0206@2|Bacteria,1MV2X@1224|Proteobacteria,1RPZS@1236|Gammaproteobacteria,46072@72273|Thiotrichales	72273|Thiotrichales	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
HKD2_k127_860661_3	1301098.PKB_4514	2.003e-139	448.0	COG0774@1|root,COG0774@2|Bacteria,1MV6T@1224|Proteobacteria,1RQ72@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis	lpxC	GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008270,GO:0008610,GO:0008654,GO:0008759,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016787,GO:0016810,GO:0016811,GO:0019213,GO:0019637,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044464,GO:0046467,GO:0046493,GO:0046872,GO:0046914,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	3.5.1.108	ko:K02535	ko00540,ko01100,map00540,map01100	M00060	R04587	RC00166,RC00300	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	iECS88_1305.ECS88_0100	LpxC
HKD2_k127_860661_6	203122.Sde_0855	8.449e-69	245.0	COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,1RMIR@1236|Gammaproteobacteria,465Y3@72275|Alteromonadaceae	1236|Gammaproteobacteria	M	COG0739 Membrane proteins related to metalloendopeptidases	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
HKD2_k127_860661_0	472759.Nhal_0500	0.0	1201.0	COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,1RM9M@1236|Gammaproteobacteria,1WWZC@135613|Chromatiales	135613|Chromatiales	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	-	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
HKD2_k127_860661_10	1123261.AXDW01000010_gene432	9.236e-35	146.0	COG0352@1|root,COG0494@1|root,COG0352@2|Bacteria,COG0494@2|Bacteria,1RCZM@1224|Proteobacteria,1RS3S@1236|Gammaproteobacteria,1X3N9@135614|Xanthomonadales	135614|Xanthomonadales	HL	Belongs to the Nudix hydrolase family	-	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX,NUDIX_4,TMP-TENI
HKD2_k127_860661_1	1280954.HPO_02959	1.606e-164	530.0	COG1012@1|root,COG1012@2|Bacteria,1QIM4@1224|Proteobacteria,2TU18@28211|Alphaproteobacteria,43Z2S@69657|Hyphomonadaceae	28211|Alphaproteobacteria	C	Aldehyde dehydrogenase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldedh
HKD2_k127_860661_7	1163409.UUA_10756	3.317e-62	222.0	COG0500@1|root,COG0500@2|Bacteria,1RAE4@1224|Proteobacteria,1S0RC@1236|Gammaproteobacteria,1X4UC@135614|Xanthomonadales	135614|Xanthomonadales	Q	Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family	tpm	-	2.1.1.67	ko:K00569	ko00983,map00983	-	R08236,R08239,R08246	RC00003,RC00980,RC02277	ko00000,ko00001,ko01000	-	-	-	TPMT
HKD2_k127_860661_12	521719.ATXQ01000003_gene2084	6.552e-20	94.0	COG3024@1|root,COG3024@2|Bacteria,1NGJ8@1224|Proteobacteria,1SC7M@1236|Gammaproteobacteria,1YGYM@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	S	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase	yacG	GO:0003674,GO:0004857,GO:0005488,GO:0008150,GO:0008270,GO:0008657,GO:0010911,GO:0030234,GO:0032780,GO:0042030,GO:0043086,GO:0043167,GO:0043169,GO:0043462,GO:0044092,GO:0046872,GO:0046914,GO:0050790,GO:0051336,GO:0051346,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0072586,GO:0098772,GO:2000371,GO:2000372	-	ko:K09862	-	-	-	-	ko00000	-	-	-	YacG
HKD2_k127_860661_8	765910.MARPU_14170	1.398e-58	215.0	COG4582@1|root,COG4582@2|Bacteria,1MW69@1224|Proteobacteria,1RNPD@1236|Gammaproteobacteria,1WWH6@135613|Chromatiales	135613|Chromatiales	D	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity	zapD	-	-	ko:K18778	-	-	-	-	ko00000,ko03036	-	-	-	ZapD
HKD2_k127_860661_9	765912.Thimo_1047	8.772e-56	203.0	COG0237@1|root,COG0237@2|Bacteria,1RCXT@1224|Proteobacteria,1S3NR@1236|Gammaproteobacteria,1WY99@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A	coaE	-	2.7.1.24	ko:K00859	ko00770,ko01100,map00770,map01100	M00120	R00130	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	CoaE
HKD2_k127_860661_5	519989.ECTPHS_01954	3.513e-113	374.0	COG1989@1|root,COG1989@2|Bacteria,1MUZF@1224|Proteobacteria,1RN90@1236|Gammaproteobacteria,1WW7R@135613|Chromatiales	135613|Chromatiales	NOU	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue	-	-	3.4.23.43	ko:K02654	-	M00331	-	-	ko00000,ko00002,ko01000,ko01002,ko02035,ko02044	3.A.15.2	-	-	DiS_P_DiS,Peptidase_A24
HKD2_k127_860661_2	572477.Alvin_0162	1.33e-153	494.0	COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,1RNV0@1236|Gammaproteobacteria,1WWAB@135613|Chromatiales	135613|Chromatiales	U	Type II secretion system	-	-	-	ko:K02653	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSF
HKD2_k127_860661_11	555778.Hneap_1579	2.764e-27	111.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,1RMBS@1236|Gammaproteobacteria,1WXAR@135613|Chromatiales	135613|Chromatiales	NU	TIGRFAM type IV-A pilus assembly ATPase PilB	-	-	-	ko:K02652	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE,T2SSE_N
HKD2_k127_888011_18	1177181.T9A_00523	3.484e-15	84.0	COG3637@1|root,COG3637@2|Bacteria,1RDPZ@1224|Proteobacteria,1S4GQ@1236|Gammaproteobacteria,1XP8B@135619|Oceanospirillales	135619|Oceanospirillales	M	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety	-	-	-	-	-	-	-	-	-	-	-	-	OMP_b-brl
HKD2_k127_888011_11	1121935.AQXX01000098_gene1656	2.251e-61	219.0	COG3807@1|root,COG3807@2|Bacteria,1RE8W@1224|Proteobacteria,1S4BU@1236|Gammaproteobacteria,1XPIQ@135619|Oceanospirillales	135619|Oceanospirillales	S	COG3103 SH3 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	OMP_b-brl,SH3_3,SH3_4
HKD2_k127_888011_1	1049564.TevJSym_aj00060	3.495e-298	939.0	COG0823@1|root,COG0823@2|Bacteria,1R3VN@1224|Proteobacteria,1RNKG@1236|Gammaproteobacteria,1J98N@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	U	COG0823 Periplasmic component of the Tol biopolymer transport system	-	-	-	-	-	-	-	-	-	-	-	-	PD40
HKD2_k127_888011_6	351348.Maqu_1822	9.307e-157	505.0	28HN6@1|root,2Z7WJ@2|Bacteria,1R5QB@1224|Proteobacteria,1RNJN@1236|Gammaproteobacteria,4667S@72275|Alteromonadaceae	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_888011_0	349521.HCH_02592	1.081e-305	957.0	COG2755@1|root,COG2755@2|Bacteria,1MXTS@1224|Proteobacteria,1RTPH@1236|Gammaproteobacteria,1XN5T@135619|Oceanospirillales	135619|Oceanospirillales	E	Concanavalin A-like lectin/glucanases superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3
HKD2_k127_888011_3	1049564.TevJSym_aj00030	2.039e-227	716.0	2BWPY@1|root,2Z8BI@2|Bacteria,1QHHB@1224|Proteobacteria,1RP8D@1236|Gammaproteobacteria,1J916@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_888011_8	396588.Tgr7_0552	2.491e-108	360.0	COG1477@1|root,COG1477@2|Bacteria,1MW6K@1224|Proteobacteria,1RNMZ@1236|Gammaproteobacteria,1WWAK@135613|Chromatiales	135613|Chromatiales	H	Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein	-	-	2.7.1.180	ko:K03734	-	-	-	-	ko00000,ko01000	-	-	-	ApbE
HKD2_k127_888011_14	864051.BurJ1DRAFT_1746	1.838e-30	128.0	COG0526@1|root,COG0526@2|Bacteria,1MZ36@1224|Proteobacteria,2WF1B@28216|Betaproteobacteria,1KPKM@119065|unclassified Burkholderiales	28216|Betaproteobacteria	CO	Glutathione peroxidase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_888011_12	864051.BurJ1DRAFT_1743	1.017e-58	209.0	2B4XH@1|root,31XQC@2|Bacteria,1RHJF@1224|Proteobacteria,2W1BJ@28216|Betaproteobacteria,1KNAC@119065|unclassified Burkholderiales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_888011_7	420662.Mpe_A1224	2.178e-132	447.0	COG0457@1|root,COG0457@2|Bacteria,1MXSS@1224|Proteobacteria,2VZB4@28216|Betaproteobacteria,1KN0Q@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_888011_4	420662.Mpe_A1225	2.355e-214	706.0	COG0457@1|root,COG1729@1|root,COG0457@2|Bacteria,COG1729@2|Bacteria,1MX82@1224|Proteobacteria,2VZ4H@28216|Betaproteobacteria,1KN47@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16
HKD2_k127_888011_17	864051.BurJ1DRAFT_1740	1.224e-17	99.0	COG0457@1|root,COG0457@2|Bacteria,1NB8N@1224|Proteobacteria,2W9UY@28216|Betaproteobacteria,1KNVB@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_2
HKD2_k127_888011_19	864051.BurJ1DRAFT_1739	4.935e-12	76.0	2AHZN@1|root,318CZ@2|Bacteria,1Q06K@1224|Proteobacteria,2W4WA@28216|Betaproteobacteria,1KNW5@119065|unclassified Burkholderiales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_888011_10	396588.Tgr7_0539	2.112e-65	232.0	COG0811@1|root,COG0811@2|Bacteria,1MX5J@1224|Proteobacteria,1RMSA@1236|Gammaproteobacteria,1X07Q@135613|Chromatiales	135613|Chromatiales	U	PFAM MotA TolQ ExbB proton channel	-	-	-	ko:K03561	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	MotA_ExbB
HKD2_k127_888011_15	1049564.TevJSym_au00050	5.948e-29	123.0	COG0848@1|root,COG0848@2|Bacteria,1RHI8@1224|Proteobacteria,1S6FK@1236|Gammaproteobacteria,1JAY5@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	U	Biopolymer transport protein ExbD/TolR	-	-	-	-	-	-	-	-	-	-	-	-	ExbD
HKD2_k127_888011_16	1385517.N800_13170	3.429e-26	121.0	COG0848@1|root,COG0848@2|Bacteria,1RENY@1224|Proteobacteria,1S3TB@1236|Gammaproteobacteria,1X7V1@135614|Xanthomonadales	135614|Xanthomonadales	U	Biopolymer transport protein ExbD/TolR	-	-	-	-	-	-	-	-	-	-	-	-	ExbD
HKD2_k127_888011_13	1049564.TevJSym_au00070	4.228e-46	184.0	COG0810@1|root,COG0810@2|Bacteria,1R65W@1224|Proteobacteria,1S133@1236|Gammaproteobacteria,1JAAK@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins	-	-	-	-	-	-	-	-	-	-	-	-	TonB_C
HKD2_k127_888011_5	1242864.D187_008317	3.79e-205	655.0	COG0369@1|root,COG0369@2|Bacteria,1QW01@1224|Proteobacteria	1224|Proteobacteria	C	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component	cysJ	-	1.14.14.1,1.6.2.4,1.8.1.2	ko:K00380,ko:K14338	ko00071,ko00380,ko00627,ko00920,ko01100,ko01120,map00071,map00380,map00627,map00920,map01100,map01120	M00176	R00858,R03629,R04121,R05259	RC00046,RC00065,RC01311	ko00000,ko00001,ko00002,ko00199,ko01000	-	-	-	FAD_binding_1,Flavodoxin_1,NAD_binding_1
HKD2_k127_888011_2	1242864.D187_008316	1.851e-258	806.0	COG0155@1|root,COG0155@2|Bacteria,1MVVB@1224|Proteobacteria,42Q2M@68525|delta/epsilon subdivisions	1224|Proteobacteria	C	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate	cysI	GO:0003674,GO:0003824,GO:0004783,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006790,GO:0008150,GO:0008152,GO:0009337,GO:0009987,GO:0016002,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0016673,GO:0019419,GO:0020037,GO:0032991,GO:0044237,GO:0044424,GO:0044464,GO:0046906,GO:0048037,GO:0050311,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0097159,GO:1901363	1.7.7.1,1.8.1.2,1.8.7.1	ko:K00366,ko:K00381,ko:K00392	ko00910,ko00920,ko01100,ko01120,map00910,map00920,map01100,map01120	M00176,M00531	R00790,R00858,R00859,R03600	RC00065,RC00176	ko00000,ko00001,ko00002,ko01000	-	-	iEC55989_1330.EC55989_3037,iECH74115_1262.ECH74115_4017,iECIAI1_1343.ECIAI1_2867,iECNA114_1301.ECNA114_2794,iECO103_1326.ECO103_3307,iECSE_1348.ECSE_3019,iECSF_1327.ECSF_2552,iECSP_1301.ECSP_3712,iECUMN_1333.ECUMN_3091,iECW_1372.ECW_m2971,iECs_1301.ECs3618,iEKO11_1354.EKO11_1005,iEcE24377_1341.EcE24377A_3065,iSFV_1184.SFV_2742,iSbBS512_1146.SbBS512_E3112,iWFL_1372.ECW_m2971,iZ_1308.Z4073	NIR_SIR,NIR_SIR_ferr
HKD2_k127_888011_9	84531.JMTZ01000081_gene1304	1.601e-97	325.0	COG0175@1|root,COG0175@2|Bacteria,1MXUR@1224|Proteobacteria,1RNC5@1236|Gammaproteobacteria,1X4PS@135614|Xanthomonadales	135614|Xanthomonadales	EH	Belongs to the PAPS reductase family. CysH subfamily	cysH	GO:0003674,GO:0003824,GO:0004604,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0016491,GO:0016667,GO:0016671,GO:0044424,GO:0044464,GO:0055114	1.8.4.10,1.8.4.8	ko:K00390	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00176	R02021	RC00007,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	-	PAPS_reduct
HKD2_k127_888011_20	1007105.PT7_0172	1.217e-10	63.0	COG0007@1|root,COG1648@1|root,COG0007@2|Bacteria,COG1648@2|Bacteria,1MUI0@1224|Proteobacteria,2VICS@28216|Betaproteobacteria,3T1JA@506|Alcaligenaceae	28216|Betaproteobacteria	H	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme	cysG	-	1.3.1.76,2.1.1.107,4.99.1.4	ko:K02302,ko:K02303	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02864,R03194,R03947	RC00003,RC00871,RC01012,RC01034	ko00000,ko00001,ko00002,ko01000	-	-	-	CysG_dimeriser,NAD_binding_7,Sirohm_synth_M,TP_methylase
HKD2_k127_8953015_2	1121374.KB891575_gene1429	6.376e-55	196.0	COG0592@1|root,COG0592@2|Bacteria,1MVD9@1224|Proteobacteria,1RMNP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria	dnaN	GO:0003674,GO:0003824,GO:0003887,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0022616,GO:0032991,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0042575,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0061695,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234	2.7.7.7	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3
HKD2_k127_8953015_1	1304275.C41B8_10415	3.541e-70	252.0	COG1195@1|root,COG1195@2|Bacteria,1MX8N@1224|Proteobacteria,1RN5P@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP	recF	GO:0000731,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009411,GO:0009416,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0018130,GO:0019438,GO:0031668,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0071897,GO:0090304,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901576	-	ko:K03629	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	SMC_N
HKD2_k127_8953015_0	1122134.KB893650_gene344	0.0	1053.0	COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,1RNB2@1236|Gammaproteobacteria,1XHZE@135619|Oceanospirillales	135619|Oceanospirillales	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
HKD2_k127_8958621_3	1123401.JHYQ01000001_gene1715	1.205e-58	213.0	COG0497@1|root,COG0497@2|Bacteria,1MUNP@1224|Proteobacteria,1RNPZ@1236|Gammaproteobacteria,45ZYF@72273|Thiotrichales	72273|Thiotrichales	L	May be involved in recombinational repair of damaged DNA	recN	-	-	ko:K03631	-	-	-	-	ko00000,ko03400	-	-	-	SMC_N
HKD2_k127_8958621_2	1249627.D779_2918	5.449e-69	246.0	COG0061@1|root,COG0061@2|Bacteria,1MUBC@1224|Proteobacteria,1RP84@1236|Gammaproteobacteria,1WXJR@135613|Chromatiales	135613|Chromatiales	G	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	nadK	-	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	NAD_kinase
HKD2_k127_8958621_0	1260251.SPISAL_04555	3.423e-118	391.0	COG1420@1|root,COG1420@2|Bacteria,1MVX4@1224|Proteobacteria,1RR2F@1236|Gammaproteobacteria,1WXB7@135613|Chromatiales	135613|Chromatiales	K	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons	hrcA	-	-	ko:K03705	-	-	-	-	ko00000,ko03000	-	-	-	HrcA,HrcA_DNA-bdg
HKD2_k127_8958621_4	1033802.SSPSH_002333	8.459e-42	160.0	COG0576@1|root,COG0576@2|Bacteria,1RH8T@1224|Proteobacteria,1S5W5@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	grpE	GO:0000166,GO:0000774,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0016043,GO:0017076,GO:0019904,GO:0022607,GO:0030234,GO:0030554,GO:0032991,GO:0036094,GO:0042802,GO:0042803,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0046983,GO:0050790,GO:0050896,GO:0051082,GO:0060589,GO:0060590,GO:0065003,GO:0065007,GO:0065009,GO:0071840,GO:0097159,GO:0098772,GO:1901265,GO:1901363	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
HKD2_k127_8958621_1	2340.JV46_27120	1.028e-107	351.0	COG0443@1|root,COG0443@2|Bacteria,1MVEN@1224|Proteobacteria,1RMDD@1236|Gammaproteobacteria,1J4HD@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	O	Heat shock 70 kDa protein	dnaK	GO:0000166,GO:0000988,GO:0000989,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008144,GO:0008150,GO:0008270,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010033,GO:0010556,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0016989,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0022607,GO:0030554,GO:0031323,GO:0031326,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0034620,GO:0035639,GO:0035966,GO:0035967,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0043169,GO:0043531,GO:0043933,GO:0044085,GO:0044183,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0061077,GO:0065003,GO:0065007,GO:0070887,GO:0071310,GO:0071840,GO:0071944,GO:0080090,GO:0097159,GO:0097367,GO:0140110,GO:1901265,GO:1901363,GO:1903506,GO:2001141	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
HKD2_k127_8970237_14	1267533.KB906736_gene961	2.708e-45	168.0	COG1725@1|root,COG1725@2|Bacteria,3Y5VN@57723|Acidobacteria,2JK5T@204432|Acidobacteriia	2|Bacteria	K	helix_turn_helix gluconate operon transcriptional repressor	ytrA	-	-	ko:K07979	-	-	-	-	ko00000,ko03000	-	-	-	GntR
HKD2_k127_8970237_6	1123073.KB899242_gene1670	5.96e-158	511.0	COG0039@1|root,COG0039@2|Bacteria,1MV57@1224|Proteobacteria,1RMAX@1236|Gammaproteobacteria,1X3NI@135614|Xanthomonadales	135614|Xanthomonadales	C	Catalyzes the reversible oxidation of malate to oxaloacetate	mdh	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006107,GO:0006108,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009060,GO:0009117,GO:0009987,GO:0015980,GO:0016491,GO:0016614,GO:0016615,GO:0016616,GO:0016999,GO:0017144,GO:0019362,GO:0019637,GO:0019674,GO:0019752,GO:0030060,GO:0034641,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044464,GO:0045333,GO:0046483,GO:0046496,GO:0051186,GO:0055086,GO:0055114,GO:0071704,GO:0072350,GO:0072524,GO:1901360,GO:1901564	1.1.1.37	ko:K00024	ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740	R00342,R07136	RC00031	ko00000,ko00001,ko00002,ko01000	-	-	-	Ldh_1_C,Ldh_1_N
HKD2_k127_8970237_2	1122604.JONR01000009_gene2401	7.256e-211	675.0	COG0531@1|root,COG0531@2|Bacteria,1R829@1224|Proteobacteria,1S076@1236|Gammaproteobacteria,1X9SG@135614|Xanthomonadales	135614|Xanthomonadales	E	Amino acid permease	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
HKD2_k127_8970237_7	1278073.MYSTI_00087	4.069e-137	446.0	COG1104@1|root,COG1104@2|Bacteria,1MU1C@1224|Proteobacteria,42M5V@68525|delta/epsilon subdivisions,2WIR6@28221|Deltaproteobacteria,2YX1M@29|Myxococcales	28221|Deltaproteobacteria	E	Aminotransferase class-V	-	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
HKD2_k127_8970237_18	111105.HR09_04715	4.34e-09	70.0	COG0607@1|root,COG0607@2|Bacteria,4NSD1@976|Bacteroidetes,2FV0P@200643|Bacteroidia,22YT4@171551|Porphyromonadaceae	976|Bacteroidetes	P	Sulfurtransferase	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
HKD2_k127_8970237_3	1415779.JOMH01000001_gene3235	3.482e-183	601.0	COG0477@1|root,COG2814@2|Bacteria,1R2KY@1224|Proteobacteria,1RZ6A@1236|Gammaproteobacteria	1236|Gammaproteobacteria	EGP	Pfam Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD2_k127_8970237_10	266117.Rxyl_2941	2.201e-65	233.0	COG0607@1|root,COG0640@1|root,COG0607@2|Bacteria,COG0640@2|Bacteria,2I98A@201174|Actinobacteria,4CSYC@84995|Rubrobacteria	84995|Rubrobacteria	K	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,Rhodanese
HKD2_k127_8970237_12	1123368.AUIS01000005_gene383	1.414e-55	201.0	COG3255@1|root,COG3255@2|Bacteria,1N5G0@1224|Proteobacteria,1S8QU@1236|Gammaproteobacteria,2NCWZ@225057|Acidithiobacillales	225057|Acidithiobacillales	I	SCP-2 sterol transfer family	-	-	-	-	-	-	-	-	-	-	-	-	SCP2
HKD2_k127_8970237_0	2340.JV46_26720	1.101e-299	927.0	COG0374@1|root,COG0374@2|Bacteria,1MWFJ@1224|Proteobacteria,1RMC3@1236|Gammaproteobacteria,1JARP@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Nickel-dependent hydrogenase	hydB	-	1.12.5.1,1.12.99.6	ko:K05922,ko:K06281	ko00633,ko01120,map00633,map01120	-	R08034	RC00250	ko00000,ko00001,ko01000	-	-	-	NiFeSe_Hases
HKD2_k127_8970237_1	396588.Tgr7_1267	9.283e-224	702.0	COG0247@1|root,COG1145@1|root,COG0247@2|Bacteria,COG1145@2|Bacteria,1MUMH@1224|Proteobacteria,1RNBY@1236|Gammaproteobacteria,1WWK6@135613|Chromatiales	135613|Chromatiales	C	PFAM Cysteine-rich	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8
HKD2_k127_8970237_11	380394.Lferr_2882	7.505e-58	222.0	COG2181@1|root,COG2181@2|Bacteria,1QQCT@1224|Proteobacteria,1S05R@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	nitrate reductase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8970237_5	870187.Thini_0276	1.431e-159	509.0	COG1740@1|root,COG1740@2|Bacteria,1MWAC@1224|Proteobacteria,1RNTJ@1236|Gammaproteobacteria,462CC@72273|Thiotrichales	72273|Thiotrichales	C	Hydrogenase (NiFe) small subunit HydA	-	-	1.12.5.1	ko:K05927	-	-	-	-	ko00000,ko01000	-	-	-	NiFe_hyd_SSU_C,Oxidored_q6
HKD2_k127_8970237_16	580332.Slit_1622	3.759e-39	151.0	COG0298@1|root,COG0680@1|root,COG0298@2|Bacteria,COG0680@2|Bacteria,1RE1C@1224|Proteobacteria,2VJ4W@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Hydrogenase expression formation protein	-	-	-	ko:K03605	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	HycI
HKD2_k127_8970237_17	1385515.N791_05720	2.096e-23	113.0	COG0640@1|root,COG0640@2|Bacteria,1N72Q@1224|Proteobacteria,1SCH5@1236|Gammaproteobacteria,1X7P3@135614|Xanthomonadales	135614|Xanthomonadales	K	transcriptional	-	-	-	-	-	-	-	-	-	-	-	-	HTH_5
HKD2_k127_8970237_9	582899.Hden_0696	4.382e-66	228.0	COG0509@1|root,COG0509@2|Bacteria,1RKRS@1224|Proteobacteria,2UAPN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Glycine cleavage H-protein	-	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
HKD2_k127_8970237_15	582899.Hden_0695	1.257e-41	164.0	2AKRU@1|root,31BIQ@2|Bacteria,1Q7DM@1224|Proteobacteria,2UEKS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8970237_4	1417296.U879_08095	4.5e-160	522.0	COG2048@1|root,COG2048@2|Bacteria,1N37J@1224|Proteobacteria,2U4AQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Cysteine-rich domain	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03389	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG
HKD2_k127_8970237_8	1417296.U879_08090	6.96e-120	389.0	COG1150@1|root,COG1150@2|Bacteria,1R874@1224|Proteobacteria,2U3QM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	4Fe-4S dicluster domain	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03390	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4_9
HKD2_k127_8970237_13	582899.Hden_0692	1.358e-52	190.0	arCOG05916@1|root,30GTU@2|Bacteria,1RDX8@1224|Proteobacteria,2U853@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8976806_2	580332.Slit_1609	2.547e-76	258.0	COG1034@1|root,COG1034@2|Bacteria,1QVC7@1224|Proteobacteria,2VI6U@28216|Betaproteobacteria,44W9N@713636|Nitrosomonadales	28216|Betaproteobacteria	C	PFAM NADH ubiquinone oxidoreductase, subunit G, iron-sulphur binding	hoxU	-	1.12.1.2	ko:K18006	-	-	-	-	ko00000,ko01000	-	-	-	Fer2_4,Fer4_15,NADH-G_4Fe-4S_3
HKD2_k127_8976806_1	1454004.AW11_03447	1.947e-101	340.0	COG1941@1|root,COG1941@2|Bacteria,1NS0E@1224|Proteobacteria,2VJH8@28216|Betaproteobacteria	28216|Betaproteobacteria	C	NADH ubiquinone oxidoreductase 20 kDa subunit	hoxY	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	1.12.1.2	ko:K18007	-	-	-	-	ko00000,ko01000	-	-	-	Oxidored_q6
HKD2_k127_8976806_0	580332.Slit_1611	4.143e-255	792.0	COG3259@1|root,COG3259@2|Bacteria,1QUQ7@1224|Proteobacteria,2VJT0@28216|Betaproteobacteria,44WEG@713636|Nitrosomonadales	28216|Betaproteobacteria	C	Belongs to the NiFe NiFeSe hydrogenase large subunit family	hoxH	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	1.12.1.2	ko:K00436	-	-	R00700	-	ko00000,ko01000	-	-	-	NiFeSe_Hases
HKD2_k127_9000529_6	1123393.KB891317_gene2207	9.363e-48	175.0	COG0668@1|root,COG0668@2|Bacteria,1N596@1224|Proteobacteria,2VQ9J@28216|Betaproteobacteria,1KSDQ@119069|Hydrogenophilales	119069|Hydrogenophilales	M	Conserved TM helix	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel,TM_helix
HKD2_k127_9000529_2	1122603.ATVI01000006_gene765	1.129e-93	315.0	COG0483@1|root,COG0483@2|Bacteria,1PPJ0@1224|Proteobacteria,1RMVD@1236|Gammaproteobacteria,1X39H@135614|Xanthomonadales	135614|Xanthomonadales	G	Inositol monophosphatase family	-	-	3.1.3.15	ko:K05602	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R03013	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
HKD2_k127_9000529_1	713586.KB900536_gene2702	2.391e-111	383.0	COG4206@1|root,COG4206@2|Bacteria,1MW63@1224|Proteobacteria,1RMFJ@1236|Gammaproteobacteria,1WWF7@135613|Chromatiales	135613|Chromatiales	H	TonB-dependent Receptor Plug	-	-	-	ko:K16092	-	-	-	-	ko00000,ko02000	1.B.14.3	-	-	Plug,TonB_dep_Rec
HKD2_k127_9000529_4	1219375.CM002139_gene1251	1.887e-73	260.0	COG2096@1|root,COG2096@2|Bacteria,1RDUF@1224|Proteobacteria,1S40D@1236|Gammaproteobacteria,1X50D@135614|Xanthomonadales	135614|Xanthomonadales	S	adenosyltransferase	-	-	2.5.1.17	ko:K00798	ko00860,ko01100,map00860,map01100	M00122	R01492,R05220,R07268	RC00533	ko00000,ko00001,ko00002,ko01000	-	-	-	Cob_adeno_trans
HKD2_k127_9000529_5	1218074.BAXZ01000012_gene2888	5.727e-65	239.0	COG0614@1|root,COG0614@2|Bacteria,1MWVF@1224|Proteobacteria,2VJ7T@28216|Betaproteobacteria,1K1P1@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Periplasmic binding protein	btuF	-	-	ko:K02016,ko:K06858	ko02010,map02010	M00240,M00241	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.13,3.A.1.14	-	-	Peripla_BP_2
HKD2_k127_9000529_7	396588.Tgr7_0638	2.01e-31	139.0	COG3725@1|root,COG3725@2|Bacteria,1MYFA@1224|Proteobacteria,1SE2J@1236|Gammaproteobacteria,1WZMR@135613|Chromatiales	135613|Chromatiales	V	Membrane protein required for beta-lactamase induction	-	-	-	ko:K03807	-	-	-	-	ko00000	-	-	-	AmpE,CobD_Cbib
HKD2_k127_9000529_3	323261.Noc_0866	3.549e-77	267.0	COG3023@1|root,COG3023@2|Bacteria,1RDHU@1224|Proteobacteria,1S3PG@1236|Gammaproteobacteria,1WWUP@135613|Chromatiales	135613|Chromatiales	V	PFAM N-acetylmuramoyl-L-alanine amidase family 2	-	-	3.5.1.28	ko:K03806	-	-	-	-	ko00000,ko01000,ko01011	-	-	-	Amidase_2
HKD2_k127_9000529_0	519989.ECTPHS_03267	1.729e-175	554.0	COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,1RP0W@1236|Gammaproteobacteria,1WWIR@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor	bioA	-	2.6.1.62	ko:K00833	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03231	RC00006,RC00887	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
HKD2_k127_9020347_25	420662.Mpe_A2111	8.604e-57	203.0	COG1611@1|root,COG1611@2|Bacteria,1RD59@1224|Proteobacteria,2VRA6@28216|Betaproteobacteria,1KKNM@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Belongs to the LOG family	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
HKD2_k127_9020347_24	869210.Marky_1203	8.04e-57	211.0	COG0159@1|root,COG0159@2|Bacteria,1WJB8@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate	trpA	-	4.2.1.20	ko:K01695	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_syntA
HKD2_k127_9020347_6	555778.Hneap_1159	3.253e-143	471.0	COG0133@1|root,COG0133@2|Bacteria,1MUS8@1224|Proteobacteria,1RP4D@1236|Gammaproteobacteria,1WW9F@135613|Chromatiales	135613|Chromatiales	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB	-	4.2.1.20	ko:K01696	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HKD2_k127_9020347_35	1122132.AQYH01000005_gene573	1.915e-24	119.0	COG0135@1|root,COG0135@2|Bacteria,1RA87@1224|Proteobacteria,2U7CH@28211|Alphaproteobacteria,4B9TV@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	Belongs to the TrpF family	trpF	-	5.3.1.24	ko:K01817	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03509	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	PRAI
HKD2_k127_9020347_29	1122609.AUGT01000012_gene4354	2.565e-38	162.0	COG0134@1|root,COG0134@2|Bacteria,2GIVV@201174|Actinobacteria,4DNTB@85009|Propionibacteriales	201174|Actinobacteria	E	Indole-3-glycerol phosphate synthase	trpC	GO:0000162,GO:0000287,GO:0003674,GO:0003824,GO:0004425,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016020,GO:0016053,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019752,GO:0030312,GO:0034641,GO:0040007,GO:0042401,GO:0042430,GO:0042435,GO:0043167,GO:0043169,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046219,GO:0046391,GO:0046394,GO:0046483,GO:0046872,GO:0071704,GO:0071944,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.1.1.48	ko:K01609	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03508	RC00944	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPS
HKD2_k127_9020347_18	429009.Adeg_1160	1.9e-78	274.0	COG0547@1|root,COG0547@2|Bacteria,1TP8U@1239|Firmicutes,247WY@186801|Clostridia,42EK5@68295|Thermoanaerobacterales	186801|Clostridia	F	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)	trpD	-	2.4.2.18,4.1.3.27	ko:K00766,ko:K13497	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R00985,R00986,R01073	RC00010,RC00440,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3
HKD2_k127_9020347_22	760568.Desku_1856	3.809e-71	258.0	COG0512@1|root,COG0512@2|Bacteria,1TT9R@1239|Firmicutes,24FR0@186801|Clostridia,261J7@186807|Peptococcaceae	186801|Clostridia	EH	TIGRFAM glutamine amidotransferase of anthranilate synthase	pabA	-	2.6.1.85,4.1.3.27	ko:K01658,ko:K01664	ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986,R01716	RC00010,RC01418,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
HKD2_k127_9020347_7	1232410.KI421415_gene3080	3.601e-126	420.0	COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,42MXN@68525|delta/epsilon subdivisions,2WJN0@28221|Deltaproteobacteria,43T7B@69541|Desulfuromonadales	28221|Deltaproteobacteria	EH	Anthranilate synthase component I, N terminal region	trpE	-	4.1.3.27	ko:K01657,ko:K13503	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
HKD2_k127_9020347_3	1297570.MESS4_110161	1.178e-202	645.0	COG0001@1|root,COG0001@2|Bacteria,1MUY5@1224|Proteobacteria,2TT6G@28211|Alphaproteobacteria,43J9D@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	H	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
HKD2_k127_9020347_5	95619.PM1_0224395	6.052e-155	515.0	COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,1RQX2@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Fad linked oxidase	-	-	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
HKD2_k127_9020347_16	1122604.JONR01000009_gene2465	1.735e-83	294.0	COG1538@1|root,COG1538@2|Bacteria,1N23P@1224|Proteobacteria,1RMXN@1236|Gammaproteobacteria,1X8EQ@135614|Xanthomonadales	135614|Xanthomonadales	MU	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
HKD2_k127_9020347_4	1123255.JHYS01000017_gene1409	1.223e-193	612.0	COG0446@1|root,COG0446@2|Bacteria,1PP77@1224|Proteobacteria,2W9FF@28216|Betaproteobacteria,4AA7E@80864|Comamonadaceae	28216|Betaproteobacteria	S	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.5.4	ko:K17218	ko00920,map00920	-	R10152	RC03155	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
HKD2_k127_9020347_0	396588.Tgr7_1129	0.0	1341.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1WWJ6@135613|Chromatiales	135613|Chromatiales	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
HKD2_k127_9020347_14	396588.Tgr7_1128	3.921e-93	317.0	COG0845@1|root,COG0845@2|Bacteria,1NQZ0@1224|Proteobacteria,1RR67@1236|Gammaproteobacteria,1WX31@135613|Chromatiales	135613|Chromatiales	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_D23
HKD2_k127_9020347_37	857087.Metme_3953	9.911e-22	102.0	COG0607@1|root,30JW6@2|Bacteria,1PGPU@1224|Proteobacteria,1RUXS@1236|Gammaproteobacteria,1XGR5@135618|Methylococcales	135618|Methylococcales	P	Protein of unknown function (DUF2892)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2892
HKD2_k127_9020347_30	450851.PHZ_c0067	7.321e-34	136.0	COG0607@1|root,COG0607@2|Bacteria,1N2R7@1224|Proteobacteria,2U9G7@28211|Alphaproteobacteria,2KH63@204458|Caulobacterales	204458|Caulobacterales	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
HKD2_k127_9020347_8	1265502.KB905951_gene847	8.609e-111	365.0	COG0491@1|root,COG0491@2|Bacteria,1MURA@1224|Proteobacteria,2VJYK@28216|Betaproteobacteria,4ABHP@80864|Comamonadaceae	28216|Betaproteobacteria	S	PFAM beta-lactamase domain protein	baeB	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HKD2_k127_9020347_33	1122185.N792_10585	4.859e-31	126.0	COG0640@1|root,COG0640@2|Bacteria,1N72Q@1224|Proteobacteria,1SCH5@1236|Gammaproteobacteria,1X7P3@135614|Xanthomonadales	135614|Xanthomonadales	K	transcriptional	-	-	-	-	-	-	-	-	-	-	-	-	HTH_5
HKD2_k127_9020347_21	1384054.N790_07920	1.121e-73	263.0	COG0730@1|root,COG0730@2|Bacteria,1MVBS@1224|Proteobacteria,1S62V@1236|Gammaproteobacteria,1X3E6@135614|Xanthomonadales	135614|Xanthomonadales	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
HKD2_k127_9020347_41	1163409.UUA_13015	3.153e-05	47.0	COG0625@1|root,COG0625@2|Bacteria,1RJVR@1224|Proteobacteria,1SA53@1236|Gammaproteobacteria,1X5M0@135614|Xanthomonadales	135614|Xanthomonadales	O	Glutathione S-transferase	-	-	-	-	-	-	-	-	-	-	-	-	GST_C_3,GST_N_3
HKD2_k127_9020347_39	765912.Thimo_0100	3.043e-19	92.0	COG2960@1|root,COG2960@2|Bacteria,1N7AH@1224|Proteobacteria,1SCH1@1236|Gammaproteobacteria,1WYUC@135613|Chromatiales	135613|Chromatiales	S	Membrane fusogenic activity	-	-	-	ko:K09806	-	-	-	-	ko00000	-	-	-	BMFP
HKD2_k127_9020347_26	1415755.JQLV01000001_gene3725	2.037e-52	188.0	COG0347@1|root,COG0347@2|Bacteria,1RGWK@1224|Proteobacteria,1S67I@1236|Gammaproteobacteria,1XKBF@135619|Oceanospirillales	135619|Oceanospirillales	K	Belongs to the P(II) protein family	-	-	-	ko:K04751,ko:K04752	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	P-II
HKD2_k127_9020347_2	243233.MCA2136	2.205e-203	643.0	COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,1RNKF@1236|Gammaproteobacteria,1XE22@135618|Methylococcales	135618|Methylococcales	U	Ammonium Transporter	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
HKD2_k127_9020347_15	243233.MCA2048	3.294e-90	308.0	COG2084@1|root,COG2084@2|Bacteria,1MUGU@1224|Proteobacteria,1RQ2D@1236|Gammaproteobacteria,1XEAH@135618|Methylococcales	135618|Methylococcales	I	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_11,NAD_binding_2
HKD2_k127_9020347_19	396588.Tgr7_0032	9.809e-78	283.0	COG2972@1|root,COG2972@2|Bacteria,1MXVQ@1224|Proteobacteria,1RQDA@1236|Gammaproteobacteria,1WYMY@135613|Chromatiales	135613|Chromatiales	T	Histidine kinase	-	-	2.7.13.3	ko:K08082	ko02020,map02020	M00493	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	His_kinase
HKD2_k127_9020347_23	519989.ECTPHS_07491	5.211e-69	243.0	COG3279@1|root,COG3279@2|Bacteria,1MUE8@1224|Proteobacteria,1RMJJ@1236|Gammaproteobacteria,1WY8N@135613|Chromatiales	135613|Chromatiales	KT	Response regulator of the LytR AlgR family	-	-	-	ko:K08083	ko02020,map02020	M00493	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	LytTR,Response_reg
HKD2_k127_9020347_11	1122604.JONR01000061_gene2107	3.911e-101	338.0	COG0181@1|root,COG0181@2|Bacteria,1MU56@1224|Proteobacteria,1RMQ8@1236|Gammaproteobacteria,1X4A7@135614|Xanthomonadales	135614|Xanthomonadales	H	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps	hemC	GO:0003674,GO:0003824,GO:0004418,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.61	ko:K01749	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00084	RC02317	ko00000,ko00001,ko00002,ko01000	-	-	-	Porphobil_deam,Porphobil_deamC
HKD2_k127_9020347_31	713587.THITH_00065	8.155e-34	141.0	COG1587@1|root,COG1587@2|Bacteria,1MWZD@1224|Proteobacteria,1RM9K@1236|Gammaproteobacteria,1WWAM@135613|Chromatiales	135613|Chromatiales	H	Uroporphyrinogen III synthase	-	-	4.2.1.75	ko:K01719	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R03165	RC01861	ko00000,ko00001,ko00002,ko01000	-	-	-	HEM4
HKD2_k127_9020347_38	247634.GPB2148_266	2.375e-19	100.0	COG2959@1|root,COG2959@2|Bacteria,1MY3A@1224|Proteobacteria,1RNJY@1236|Gammaproteobacteria,1J63W@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	H	enzyme of heme biosynthesis	hemX	-	2.1.1.107,4.2.1.75	ko:K02496,ko:K13543	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R03165,R03194	RC00003,RC00871,RC01861	ko00000,ko00001,ko00002,ko01000	-	-	iAF1260.b3803,iBWG_1329.BWG_3482,iECDH1ME8569_1439.ECDH1ME8569_3682,iECUMN_1333.ECUMN_4327,iECs_1301.ECs4733,iEcDH1_1363.EcDH1_4176,iJO1366.b3803,iJR904.b3803,iPC815.YPO3851,iUMN146_1321.UM146_19140,iY75_1357.Y75_RS18060,iZ_1308.Z5317	HemX
HKD2_k127_9020347_27	713586.KB900536_gene2162	6.562e-51	196.0	COG3071@1|root,COG3071@2|Bacteria,1MU7A@1224|Proteobacteria,1RMRG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	enzyme of heme biosynthesis	hemY	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K02498	-	-	-	-	ko00000	-	-	-	HemY_N,TPR_2
HKD2_k127_9020347_13	1123401.JHYQ01000026_gene3281	6.643e-96	325.0	COG0543@1|root,COG0633@1|root,COG0543@2|Bacteria,COG0633@2|Bacteria,1MV72@1224|Proteobacteria,1RPH5@1236|Gammaproteobacteria,463NF@72273|Thiotrichales	72273|Thiotrichales	CH	Oxidoreductase FAD-binding domain	-	-	1.17.1.1	ko:K00523	ko00520,map00520	-	R03391,R03392	RC00230	ko00000,ko00001,ko01000	-	-	-	FAD_binding_6,Fer2,NAD_binding_1
HKD2_k127_9020347_20	1121920.AUAU01000005_gene929	1.065e-76	267.0	COG0451@1|root,COG0451@2|Bacteria,3Y95U@57723|Acidobacteria	57723|Acidobacteria	GM	NAD dependent epimerase/dehydratase family	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
HKD2_k127_9020347_12	765911.Thivi_2388	4.493e-99	331.0	COG0253@1|root,COG0253@2|Bacteria,1MWDH@1224|Proteobacteria,1RMGV@1236|Gammaproteobacteria,1WVYQ@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan	dapF	-	5.1.1.7	ko:K01778	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00527	R02735	RC00302	ko00000,ko00001,ko00002,ko01000	-	-	-	DAP_epimerase
HKD2_k127_9020347_32	1049564.TevJSym_at00470	8.668e-34	140.0	COG3159@1|root,COG3159@2|Bacteria,1R4BP@1224|Proteobacteria,1S9SC@1236|Gammaproteobacteria,1J612@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	protein conserved in bacteria	yigA	-	-	ko:K09921	-	-	-	-	ko00000	-	-	-	DUF484
HKD2_k127_9020347_9	1049564.TevJSym_at00460	5.974e-102	346.0	COG4973@1|root,COG4973@2|Bacteria,1MUJJ@1224|Proteobacteria,1RMJG@1236|Gammaproteobacteria,1J4JX@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	D	Belongs to the 'phage' integrase family. XerC subfamily	xerC	GO:0000150,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006276,GO:0006310,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008907,GO:0009009,GO:0009037,GO:0009987,GO:0015074,GO:0032991,GO:0034641,GO:0042150,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0048476,GO:0071139,GO:0071704,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363	-	ko:K03733	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
HKD2_k127_9020347_17	765910.MARPU_15960	5.024e-80	270.0	COG5405@1|root,COG5405@2|Bacteria,1MVF2@1224|Proteobacteria,1RP7P@1236|Gammaproteobacteria,1WVXJ@135613|Chromatiales	135613|Chromatiales	O	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery	hslV	-	3.4.25.2	ko:K01419	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Proteasome
HKD2_k127_9020347_1	765914.ThisiDRAFT_2397	2.93e-205	646.0	COG1220@1|root,COG1220@2|Bacteria,1MVK9@1224|Proteobacteria,1RMYV@1236|Gammaproteobacteria,1WWCI@135613|Chromatiales	135613|Chromatiales	O	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis	hslU	-	-	ko:K03667	-	-	-	-	ko00000,ko03110	-	-	-	AAA_2,ClpB_D2-small
HKD2_k127_9020347_28	472759.Nhal_2367	2.1e-46	174.0	COG3536@1|root,COG3536@2|Bacteria,1MZ5M@1224|Proteobacteria,1S8TB@1236|Gammaproteobacteria,1WYD9@135613|Chromatiales	135613|Chromatiales	S	Protein of unknown function (DUF971)	-	-	-	-	-	-	-	-	-	-	-	-	DUF971
HKD2_k127_9020347_10	1033802.SSPSH_002508	8.221e-102	337.0	COG0500@1|root,COG2226@2|Bacteria,1MX8I@1224|Proteobacteria,1RMAU@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2)	ubiE	GO:0003674,GO:0003824,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008425,GO:0008757,GO:0009058,GO:0009108,GO:0009233,GO:0009234,GO:0009987,GO:0016740,GO:0016741,GO:0030580,GO:0032259,GO:0042180,GO:0042181,GO:0043333,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	iAF1260.b3833,iBWG_1329.BWG_3511,iE2348C_1286.E2348C_4147,iEC042_1314.EC042_4213,iEC55989_1330.EC55989_4310,iECDH10B_1368.ECDH10B_4024,iECDH1ME8569_1439.ECDH1ME8569_3712,iECH74115_1262.ECH74115_5274,iECIAI1_1343.ECIAI1_4028,iECIAI39_1322.ECIAI39_3162,iECO103_1326.ECO103_4330,iECO111_1330.ECO111_4661,iECO26_1355.ECO26_4752,iECSE_1348.ECSE_4121,iECSP_1301.ECSP_4888,iECUMN_1333.ECUMN_4359,iECW_1372.ECW_m4135,iECs_1301.ECs4763,iEKO11_1354.EKO11_4524,iETEC_1333.ETEC_4110,iEcDH1_1363.EcDH1_4146,iEcE24377_1341.EcE24377A_4354,iEcHS_1320.EcHS_A4057,iEcSMS35_1347.EcSMS35_4216,iEcolC_1368.EcolC_4175,iG2583_1286.G2583_4633,iJO1366.b3833,iJR904.b3833,iSBO_1134.SBO_3847,iSDY_1059.SDY_3910,iSFV_1184.SFV_3665,iSF_1195.SF3911,iSFxv_1172.SFxv_4263,iSSON_1240.SSON_4008,iS_1188.S3843,iSbBS512_1146.SbBS512_E4305,iUMNK88_1353.UMNK88_4663,iWFL_1372.ECW_m4135,iY75_1357.Y75_RS17910,iZ_1308.Z5355	Ubie_methyltran
HKD2_k127_9020347_34	768671.ThimaDRAFT_1560	2.604e-25	114.0	COG3165@1|root,COG3165@2|Bacteria,1R1CM@1224|Proteobacteria,1S1SM@1236|Gammaproteobacteria,1WWJP@135613|Chromatiales	135613|Chromatiales	S	Sterol-binding domain protein	-	-	-	ko:K03690	-	-	-	-	ko00000	-	-	-	SCP2
HKD2_k127_9020347_36	396588.Tgr7_0061	7.092e-22	100.0	COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,1RNQM@1236|Gammaproteobacteria,1WWEC@135613|Chromatiales	135613|Chromatiales	S	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis	ubiB	-	-	ko:K03688	-	-	-	-	ko00000	-	-	-	ABC1
HKD2_k127_9037924_3	483219.LILAB_00455	6.257e-49	178.0	COG3791@1|root,COG3791@2|Bacteria,1NC41@1224|Proteobacteria,4337H@68525|delta/epsilon subdivisions,2WXGD@28221|Deltaproteobacteria,2Z206@29|Myxococcales	28221|Deltaproteobacteria	S	Glutathione-dependent formaldehyde-activating	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9037924_0	1122603.ATVI01000011_gene2091	1.833e-271	847.0	COG0449@1|root,COG0449@2|Bacteria,1MW4K@1224|Proteobacteria,1RMVN@1236|Gammaproteobacteria,1X43R@135614|Xanthomonadales	135614|Xanthomonadales	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
HKD2_k127_9037924_2	378806.STAUR_6136	4.272e-65	228.0	COG3791@1|root,COG3791@2|Bacteria,1N031@1224|Proteobacteria,433ED@68525|delta/epsilon subdivisions,2WY6I@28221|Deltaproteobacteria,2Z0HK@29|Myxococcales	28221|Deltaproteobacteria	S	Glutathione-dependent formaldehyde-activating enzyme	-	-	-	-	-	-	-	-	-	-	-	-	GFA
HKD2_k127_9037924_1	572477.Alvin_0048	1.519e-173	555.0	COG1207@1|root,COG1207@2|Bacteria,1MUPH@1224|Proteobacteria,1RNKE@1236|Gammaproteobacteria,1WWG8@135613|Chromatiales	135613|Chromatiales	M	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain	glmU	-	2.3.1.157,2.7.7.23	ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transf_3
HKD2_k127_9037924_6	1300345.LF41_1036	1.252e-24	110.0	2DSYW@1|root,33HZI@2|Bacteria,1NKP8@1224|Proteobacteria,1SISV@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9037924_5	1300345.LF41_1036	7.215e-25	110.0	2DSYW@1|root,33HZI@2|Bacteria,1NKP8@1224|Proteobacteria,1SISV@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9037924_7	1300345.LF41_1036	1.426e-24	108.0	2DSYW@1|root,33HZI@2|Bacteria,1NKP8@1224|Proteobacteria,1SISV@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9037924_8	438753.AZC_4005	2.106e-09	63.0	2EDPA@1|root,33B4W@2|Bacteria,1NH4B@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9037924_4	522306.CAP2UW1_4351	2.818e-37	143.0	COG0355@1|root,COG0355@2|Bacteria,1RHE4@1224|Proteobacteria,2VR2R@28216|Betaproteobacteria,1KQ1Z@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpC	-	-	ko:K02114	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_DE,ATP-synt_DE_N
HKD2_k127_9078494_1	1121127.JAFA01000078_gene6670	4.489e-280	871.0	COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,2VJIJ@28216|Betaproteobacteria,1JZQJ@119060|Burkholderiaceae	28216|Betaproteobacteria	G	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties	glgP	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	Phosphorylase
HKD2_k127_9078494_0	1169143.KB911035_gene2454	0.0	1435.0	COG3957@1|root,COG3957@2|Bacteria,1MVSE@1224|Proteobacteria,2VIGM@28216|Betaproteobacteria,1K1A2@119060|Burkholderiaceae	28216|Betaproteobacteria	G	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase	xfp	-	4.1.2.22,4.1.2.9	ko:K01621	ko00030,ko00710,ko01100,ko01120,map00030,map00710,map01100,map01120	-	R00761,R01621	RC00032,RC00226	ko00000,ko00001,ko01000	-	-	-	XFP,XFP_C,XFP_N
HKD2_k127_9078494_3	493475.GARC_5344	2.451e-109	372.0	COG0282@1|root,COG0282@2|Bacteria,1MW61@1224|Proteobacteria,1RMKB@1236|Gammaproteobacteria,464JF@72275|Alteromonadaceae	1236|Gammaproteobacteria	H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction	ackA	-	2.7.2.1,2.7.2.15	ko:K00925,ko:K19697	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00315,R01353	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetate_kinase
HKD2_k127_9078494_2	426114.THI_0164	8.242e-189	594.0	COG0191@1|root,COG0191@2|Bacteria,1MURX@1224|Proteobacteria,2VHGI@28216|Betaproteobacteria,1KJFJ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	G	Fructose-bisphosphate aldolase, class II, Calvin cycle subtype	fba	-	4.1.2.13	ko:K01624	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167,M00344,M00345	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	F_bP_aldolase
HKD2_k127_9078494_4	1026882.MAMP_01555	4.212e-07	61.0	2AUKY@1|root,31K9Q@2|Bacteria,1RH1X@1224|Proteobacteria,1SD4J@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Lipid A 3-O-deacylase (PagL)	-	-	-	-	-	-	-	-	-	-	-	-	PagL
HKD2_k127_9100077_0	264198.Reut_A2994	5.547e-249	779.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2VI0I@28216|Betaproteobacteria,1K4G7@119060|Burkholderiaceae	28216|Betaproteobacteria	IQ	PFAM AMP-dependent synthetase and ligase	fadD	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
HKD2_k127_9100077_1	1267533.KB906734_gene3765	1.152e-131	429.0	COG2040@1|root,COG2040@2|Bacteria	2|Bacteria	E	homocysteine	-	-	2.1.1.10	ko:K00547	ko00270,ko01100,ko01110,map00270,map01100,map01110	-	R00650	RC00003,RC00035	ko00000,ko00001,ko01000	-	-	-	S-methyl_trans
HKD2_k127_9100077_2	627192.SLG_15650	8.997e-18	87.0	29WJ0@1|root,30I58@2|Bacteria,1RCAX@1224|Proteobacteria,2U6YS@28211|Alphaproteobacteria,2KDDA@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9104423_0	344747.PM8797T_03274	4.587e-155	510.0	COG3593@1|root,COG3593@2|Bacteria,2J4IU@203682|Planctomycetes	203682|Planctomycetes	L	AAA ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9115458_5	1267535.KB906767_gene3393	5.677e-66	231.0	2905E@1|root,2ZMVA@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Phenol_MetA_deg
HKD2_k127_9115458_0	1267534.KB906758_gene2210	1.354e-194	618.0	COG1228@1|root,COG1228@2|Bacteria,3Y47R@57723|Acidobacteria,2JMEC@204432|Acidobacteriia	204432|Acidobacteriia	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
HKD2_k127_9115458_7	351607.Acel_0967	4.236e-31	124.0	COG1522@1|root,COG1522@2|Bacteria,2IQD4@201174|Actinobacteria,4ETA3@85013|Frankiales	201174|Actinobacteria	K	Lrp/AsnC ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg
HKD2_k127_9115458_4	414684.RC1_2508	1.348e-75	263.0	COG0625@1|root,COG0625@2|Bacteria,1RA4Y@1224|Proteobacteria,2U5B6@28211|Alphaproteobacteria,2JRTT@204441|Rhodospirillales	204441|Rhodospirillales	O	maleylacetoacetate isomerase	maiA	-	5.2.1.4	ko:K01801	ko00350,ko01100,ko01120,map00350,map01100,map01120	-	R03868	RC00867	ko00000,ko00001,ko01000	-	-	-	GST_C_2,GST_C_3,GST_N,GST_N_3
HKD2_k127_9115458_3	1123073.KB899241_gene2973	5.344e-92	308.0	COG0179@1|root,COG0179@2|Bacteria,1MVFA@1224|Proteobacteria,1RN6Y@1236|Gammaproteobacteria,1X54M@135614|Xanthomonadales	135614|Xanthomonadales	Q	fumarylacetoacetate hydrolase	-	-	3.7.1.20	ko:K16165	ko00350,ko01100,ko01120,map00350,map01100,map01120	-	R01085	RC00326,RC00446	ko00000,ko00001,ko01000	-	-	-	FAA_hydrolase
HKD2_k127_9115458_1	1121033.AUCF01000008_gene5743	2.975e-191	617.0	COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,2TQJS@28211|Alphaproteobacteria,2JPIV@204441|Rhodospirillales	204441|Rhodospirillales	I	COG1960 Acyl-CoA dehydrogenases	-	-	-	ko:K20035	ko00920,map00920	-	R11130	RC03363	ko00000,ko00001,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N
HKD2_k127_9115458_6	518766.Rmar_1468	7.798e-54	195.0	COG2050@1|root,COG2050@2|Bacteria,4NX1Y@976|Bacteroidetes,1FJMP@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	Q	Thioesterase superfamily	-	-	3.1.2.28	ko:K19222	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R07262	RC00004,RC00174	ko00000,ko00001,ko00002,ko01000	-	-	-	4HBT
HKD2_k127_9115458_2	187272.Mlg_2860	1.632e-133	438.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,1RNBG@1236|Gammaproteobacteria,1WWSC@135613|Chromatiales	135613|Chromatiales	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
HKD2_k127_913455_2	1122619.KB892284_gene1913	6.727e-15	75.0	COG0677@1|root,COG0677@2|Bacteria,1MUC6@1224|Proteobacteria,2VJ7A@28216|Betaproteobacteria,3T1BK@506|Alcaligenaceae	28216|Betaproteobacteria	M	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	wbpO	-	-	ko:K02474	ko00520,map00520	-	R06894	RC00291	ko00000,ko00001,ko01000,ko01005	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
HKD2_k127_913455_1	314278.NB231_03225	2.828e-164	522.0	COG0451@1|root,COG0451@2|Bacteria,1MU7J@1224|Proteobacteria,1RPTA@1236|Gammaproteobacteria,1WWHP@135613|Chromatiales	135613|Chromatiales	M	PFAM NAD-dependent epimerase dehydratase	-	-	5.1.3.6	ko:K08679	ko00520,ko01100,map00520,map01100	-	R01385	RC00289	ko00000,ko00001,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
HKD2_k127_913455_0	187303.BN69_3623	1.209e-175	572.0	COG0166@1|root,COG0166@2|Bacteria,1MUFP@1224|Proteobacteria,2TQKP@28211|Alphaproteobacteria,36X7B@31993|Methylocystaceae	28211|Alphaproteobacteria	G	Phosphoglucose isomerase	pgi	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	5.3.1.9	ko:K01810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114	R02739,R02740,R03321	RC00376,RC00563	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGI
HKD2_k127_9199071_4	1150626.PHAMO_570049	5.912e-29	128.0	COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,2TSCY@28211|Alphaproteobacteria,2JQXF@204441|Rhodospirillales	204441|Rhodospirillales	E	COG0367 Asparagine synthase (glutamine-hydrolyzing)	-	-	-	-	-	-	-	-	-	-	-	-	Asn_synthase,GATase_7
HKD2_k127_9199071_1	335283.Neut_0907	1.331e-72	261.0	COG0193@1|root,COG0770@1|root,COG0193@2|Bacteria,COG0770@2|Bacteria,1RHXY@1224|Proteobacteria	1224|Proteobacteria	M	Mur ligase middle domain protein	-	-	6.3.2.10	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	-	R04573,R04617	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase_M,Pept_tRNA_hydro
HKD2_k127_9199071_5	1121011.AUCB01000004_gene2691	1.928e-08	64.0	2E6PT@1|root,32JFJ@2|Bacteria,4PEY2@976|Bacteroidetes,1IFIA@117743|Flavobacteriia,23I7J@178469|Arenibacter	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9199071_6	595460.RRSWK_05931	6.997e-07	61.0	COG3146@1|root,COG3146@2|Bacteria,2J463@203682|Planctomycetes	203682|Planctomycetes	S	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_6
HKD2_k127_9199071_3	1333523.L593_06865	6.387e-31	140.0	COG3919@1|root,arCOG06897@2157|Archaea,2XUFQ@28890|Euryarchaeota,23U89@183963|Halobacteria	183963|Halobacteria	S	COG0458 Carbamoylphosphate synthase large subunit (split gene in MJ)	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_3,CPSase_L_D2
HKD2_k127_9199071_2	305700.B447_02753	9.677e-51	197.0	COG1541@1|root,COG1541@2|Bacteria,1MV1W@1224|Proteobacteria,2VMX6@28216|Betaproteobacteria,2KVNW@206389|Rhodocyclales	206389|Rhodocyclales	H	Capsular polysaccharide biosynthesis protein CapK	-	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding
HKD2_k127_9199071_0	1469245.JFBG01000010_gene592	1.006e-92	310.0	COG1893@1|root,COG1893@2|Bacteria,1MX5M@1224|Proteobacteria,1RYQS@1236|Gammaproteobacteria,1WWAX@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid	-	-	-	-	-	-	-	-	-	-	-	-	ApbA,ApbA_C
HKD2_k127_9338903_4	1123377.AUIV01000001_gene989	1.058e-98	328.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,1RM93@1236|Gammaproteobacteria,1X3A8@135614|Xanthomonadales	135614|Xanthomonadales	I	Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation	atoB	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
HKD2_k127_9338903_5	1122604.JONR01000013_gene3250	3.479e-95	317.0	COG1028@1|root,COG1028@2|Bacteria,1MUBQ@1224|Proteobacteria,1RQJT@1236|Gammaproteobacteria	1236|Gammaproteobacteria	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	fabG	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short,adh_short_C2
HKD2_k127_9338903_6	292.DM42_7364	8.635e-83	286.0	COG1028@1|root,COG1028@2|Bacteria,1MUBQ@1224|Proteobacteria,2VHU8@28216|Betaproteobacteria,1JZYE@119060|Burkholderiaceae	28216|Betaproteobacteria	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short,adh_short_C2
HKD2_k127_9338903_2	1234364.AMSF01000066_gene2273	3.601e-228	717.0	COG0644@1|root,COG2440@1|root,COG0644@2|Bacteria,COG2440@2|Bacteria,1MVU6@1224|Proteobacteria,1RNY5@1236|Gammaproteobacteria,1X31X@135614|Xanthomonadales	135614|Xanthomonadales	C	Electron transfer flavoprotein-ubiquinone oxidoreductase	etf-QO	-	1.5.5.1	ko:K00311	-	-	-	-	ko00000,ko01000	-	-	-	ETF_QO,FAD_binding_2,NAD_binding_8,Thi4
HKD2_k127_9338903_1	1042375.AFPL01000038_gene1524	1.402e-264	829.0	COG0365@1|root,COG0365@2|Bacteria,1MUX7@1224|Proteobacteria,1RPGT@1236|Gammaproteobacteria,465WE@72275|Alteromonadaceae	1236|Gammaproteobacteria	I	COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases	acsA	-	6.2.1.16	ko:K01907	ko00280,ko00650,map00280,map00650	-	R01357	RC00004,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
HKD2_k127_9338903_3	187272.Mlg_0334	2.668e-103	348.0	COG1485@1|root,COG1485@2|Bacteria,1MUUW@1224|Proteobacteria,1RMTJ@1236|Gammaproteobacteria,1WW2P@135613|Chromatiales	135613|Chromatiales	D	Reduces the stability of FtsZ polymers in the presence of ATP	zapE	-	-	ko:K06916	-	-	-	-	ko00000,ko03036	-	-	-	AFG1_ATPase
HKD2_k127_9338903_7	1121015.N789_13405	5.603e-37	151.0	COG1846@1|root,COG1846@2|Bacteria,1N1CJ@1224|Proteobacteria,1SCUJ@1236|Gammaproteobacteria,1X6IP@135614|Xanthomonadales	135614|Xanthomonadales	K	MarR family transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	MarR_2
HKD2_k127_9338903_0	266117.Rxyl_2529	0.0	1433.0	COG2902@1|root,COG2902@2|Bacteria,2GK0C@201174|Actinobacteria,4CPJ1@84995|Rubrobacteria	84995|Rubrobacteria	E	Bacterial NAD-glutamate dehydrogenase	-	-	1.4.1.2	ko:K15371	ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100	-	R00243	RC00006,RC02799	ko00000,ko00001,ko01000	-	-	-	Bac_GDH
HKD2_k127_9359994_1	1234364.AMSF01000002_gene2296	5.278e-45	169.0	COG0344@1|root,COG0344@2|Bacteria,1RD4Z@1224|Proteobacteria,1RN1J@1236|Gammaproteobacteria,1X68Z@135614|Xanthomonadales	135614|Xanthomonadales	I	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP	plsY	-	2.3.1.15	ko:K08591	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	G3P_acyltransf
HKD2_k127_9359994_3	1500890.JQNL01000001_gene648	3.443e-34	143.0	COG0599@1|root,COG0599@2|Bacteria,1N38Z@1224|Proteobacteria,1S5G6@1236|Gammaproteobacteria,1X6C8@135614|Xanthomonadales	135614|Xanthomonadales	S	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity	-	-	-	-	-	-	-	-	-	-	-	-	CMD
HKD2_k127_9359994_2	1161401.ASJA01000005_gene2488	1.745e-34	140.0	COG0662@1|root,COG0662@2|Bacteria,1N5XM@1224|Proteobacteria,2VG9V@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Lipocalin-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Lipocalin_5
HKD2_k127_9359994_0	1356852.N008_01240	6.475e-75	263.0	COG4874@1|root,COG4874@2|Bacteria,4NFG3@976|Bacteroidetes,47KEY@768503|Cytophagia	976|Bacteroidetes	S	Amidinotransferase	-	-	-	-	-	-	-	-	-	-	-	-	Amidinotransf
HKD2_k127_9359994_4	1210884.HG799463_gene9989	2.609e-09	59.0	COG1595@1|root,COG1595@2|Bacteria,2IZXS@203682|Planctomycetes	203682|Planctomycetes	K	Sigma-70, region 4	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
HKD2_k127_9376639_2	335659.S23_19590	5.513e-29	118.0	COG3119@1|root,COG3119@2|Bacteria,1MV92@1224|Proteobacteria,2TTXG@28211|Alphaproteobacteria,3JVJZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
HKD2_k127_9376639_0	335659.S23_19590	0.0	1452.0	COG3119@1|root,COG3119@2|Bacteria,1MV92@1224|Proteobacteria,2TTXG@28211|Alphaproteobacteria,3JVJZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
HKD2_k127_9376639_1	159450.NH14_20025	1.737e-152	489.0	COG0641@1|root,COG0641@2|Bacteria,1MX3M@1224|Proteobacteria,2VYFJ@28216|Betaproteobacteria,1K4C2@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Radical SAM superfamily	-	-	-	ko:K06871	-	-	-	-	ko00000	-	-	-	Fer4_12,Radical_SAM,SPASM
## 2615 queries scanned
## Total time (seconds): 73.24449729919434
## Rate: 35.70 q/s