## Fri Nov 15 21:26:09 2024
## emapper-2.1.12
## /data/home/zkh/miniconda3/envs/eggnog-mapper/bin/emapper.py -i /data/home/zkh/binning/bin_4635/bin/bin9/HKD_3_bin.23.fa -m mmseqs --itype genome -o HKD_3_bin.23 --output_dir /data/home/zkh/meta_analysis/eggnog-mapper/4635/HKD_3_bin.23 --cpu 28
##
#query	seed_ortholog	evalue	score	eggNOG_OGs	max_annot_lvl	COG_category	Description	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	PFAMs
HKD3_k127_113601_0	1504672.669786222	9.893e-85	282.0	COG0148@1|root,COG0148@2|Bacteria,1MU1N@1224|Proteobacteria,2VH7Y@28216|Betaproteobacteria,4A9T6@80864|Comamonadaceae	28216|Betaproteobacteria	F	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	GO:0000015,GO:0000287,GO:0003674,GO:0003824,GO:0004634,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005856,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009986,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016829,GO:0016835,GO:0016836,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0032991,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042802,GO:0042866,GO:0043167,GO:0043169,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046872,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1902494	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
HKD3_k127_113601_2	1163617.SCD_n01609	2.026e-29	123.0	COG2919@1|root,COG2919@2|Bacteria,1N7AA@1224|Proteobacteria,2VVQJ@28216|Betaproteobacteria	28216|Betaproteobacteria	D	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic	ftsB	-	-	ko:K05589	-	-	-	-	ko00000,ko03036	-	-	-	DivIC
HKD3_k127_113601_1	1163617.SCD_n01614	9.072e-61	221.0	COG0566@1|root,COG0566@2|Bacteria,1MWBE@1224|Proteobacteria,2WGF7@28216|Betaproteobacteria	28216|Betaproteobacteria	J	methyltransferase	-	-	-	ko:K03437	-	-	-	-	ko00000,ko03016	-	-	-	SpoU_methylase
HKD3_k127_1211036_1	522306.CAP2UW1_3277	2.3e-84	288.0	COG0741@1|root,COG0790@1|root,COG0741@2|Bacteria,COG0790@2|Bacteria,1MZ4X@1224|Proteobacteria,2VM6E@28216|Betaproteobacteria	28216|Betaproteobacteria	M	lytic transglycosylase	-	-	-	-	-	-	-	-	-	-	-	-	SLT,Sel1
HKD3_k127_1211036_0	305700.B447_17831	1.506e-84	287.0	COG0265@1|root,COG0265@2|Bacteria,1R9ZV@1224|Proteobacteria,2VQ55@28216|Betaproteobacteria,2KW3P@206389|Rhodocyclales	206389|Rhodocyclales	O	COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain	-	-	-	-	-	-	-	-	-	-	-	-	Trypsin_2
HKD3_k127_1211036_2	62928.azo0471	2.352e-60	219.0	COG1434@1|root,COG1434@2|Bacteria,1MVW8@1224|Proteobacteria,2VSTA@28216|Betaproteobacteria,2KWND@206389|Rhodocyclales	206389|Rhodocyclales	S	DUF218 domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF218
HKD3_k127_1211036_3	1366050.N234_13605	3.384e-13	76.0	COG0557@1|root,COG0557@2|Bacteria,1MUS6@1224|Proteobacteria,2VHBJ@28216|Betaproteobacteria,1K3JV@119060|Burkholderiaceae	28216|Betaproteobacteria	J	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs	rnr	-	-	ko:K12573	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	OB_RNB,RNB,S1
HKD3_k127_1242769_2	911045.PSE_0437	2.677e-36	139.0	COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,2TQQH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	ABC-type dipeptide transport system periplasmic component	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
HKD3_k127_1242769_0	568706.BN118_0437	1.435e-219	692.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2VHNV@28216|Betaproteobacteria,3T1X2@506|Alcaligenaceae	28216|Betaproteobacteria	C	belongs to the aldehyde dehydrogenase family	-	-	1.2.1.3	ko:K00128	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
HKD3_k127_1242769_1	1265502.KB905945_gene654	1.768e-94	315.0	COG1028@1|root,COG1028@2|Bacteria,1MUFX@1224|Proteobacteria,2VMB3@28216|Betaproteobacteria,4ACE3@80864|Comamonadaceae	28216|Betaproteobacteria	IQ	PFAM Short-chain dehydrogenase reductase SDR	tsaC	GO:0003674,GO:0003824,GO:0006725,GO:0008150,GO:0008152,GO:0009987,GO:0010130,GO:0016043,GO:0016491,GO:0016614,GO:0016616,GO:0018913,GO:0018915,GO:0022607,GO:0042537,GO:0043933,GO:0044085,GO:0044237,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:1901360	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HKD3_k127_124533_11	748280.NH8B_0285	4.002e-53	199.0	COG0223@1|root,COG0223@2|Bacteria,1MU4Q@1224|Proteobacteria,2VIS2@28216|Betaproteobacteria,2KPK1@206351|Neisseriales	206351|Neisseriales	J	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus	fmt	-	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	-	Formyl_trans_C,Formyl_trans_N
HKD3_k127_124533_10	76114.ebB91	3.484e-65	228.0	COG0242@1|root,COG0242@2|Bacteria,1RA2P@1224|Proteobacteria,2VQ4N@28216|Betaproteobacteria,2KW47@206389|Rhodocyclales	206389|Rhodocyclales	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions	def	-	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	Pep_deformylase
HKD3_k127_124533_8	1163617.SCD_n00008	1.643e-82	292.0	COG1652@1|root,COG1652@2|Bacteria,1MUBV@1224|Proteobacteria,2VIZJ@28216|Betaproteobacteria	28216|Betaproteobacteria	S	PFAM Peptidoglycan-binding LysM	-	-	-	-	-	-	-	-	-	-	-	-	LysM
HKD3_k127_124533_5	1123393.KB891332_gene2766	4.176e-99	351.0	COG0758@1|root,COG0758@2|Bacteria,1MVF6@1224|Proteobacteria,2VH3W@28216|Betaproteobacteria,1KRGG@119069|Hydrogenophilales	119069|Hydrogenophilales	LU	DNA recombination-mediator protein A	-	-	-	ko:K04096	-	-	-	-	ko00000	-	-	-	DNA_processg_A
HKD3_k127_124533_0	640081.Dsui_0821	0.0	1150.0	COG0550@1|root,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,2VHUF@28216|Betaproteobacteria,2KUMN@206389|Rhodocyclales	206389|Rhodocyclales	L	DNA topoisomerase III	-	-	5.99.1.2	ko:K03169	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	Topoisom_bac,Toprim,Toprim_Crpt
HKD3_k127_124533_12	1265502.KB905960_gene315	1.011e-24	104.0	COG3071@1|root,COG3071@2|Bacteria,1N6Y8@1224|Proteobacteria,2VW5A@28216|Betaproteobacteria	28216|Betaproteobacteria	H	Protein of unknown function (DUF2905)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2905
HKD3_k127_124533_7	402626.Rpic_4367	5.32e-83	289.0	COG0845@1|root,COG0845@2|Bacteria,1PJHF@1224|Proteobacteria,2VIRN@28216|Betaproteobacteria,1KBW0@119060|Burkholderiaceae	28216|Betaproteobacteria	M	HlyD family secretion protein	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_3
HKD3_k127_124533_2	517417.Cpar_1162	5.564e-182	602.0	COG0577@1|root,COG0577@2|Bacteria,1FEWX@1090|Chlorobi	1090|Chlorobi	V	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX
HKD3_k127_124533_6	717785.HYPMC_3229	8.364e-93	311.0	COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,2VEU2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	V	ABC transporter	-	-	-	ko:K02003,ko:K05685	ko02010,map02010	M00258,M00709	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.122.1,3.A.1.122.12	-	-	ABC_tran
HKD3_k127_124533_3	381666.H16_B1608	1.66e-119	426.0	COG5621@1|root,COG5621@2|Bacteria,1MUVF@1224|Proteobacteria,2VHMT@28216|Betaproteobacteria,1K20W@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Lipocalin-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CrtC,Lipocalin_9
HKD3_k127_124533_1	381666.H16_B1609	2.007e-245	794.0	COG0577@1|root,COG0577@2|Bacteria,1MVCT@1224|Proteobacteria,2VJAI@28216|Betaproteobacteria,1K2BP@119060|Burkholderiaceae	28216|Betaproteobacteria	MV	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HKD3_k127_124533_9	381666.H16_B1610	1.396e-79	271.0	COG1136@1|root,COG1136@2|Bacteria,1NCFC@1224|Proteobacteria,2VIQD@28216|Betaproteobacteria,1K18U@119060|Burkholderiaceae	28216|Betaproteobacteria	V	PFAM ABC transporter related	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD3_k127_124533_4	1385935.N836_21720	1.479e-103	349.0	COG2006@1|root,COG2006@2|Bacteria,1G0X0@1117|Cyanobacteria	1117|Cyanobacteria	S	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
HKD3_k127_124533_14	518766.Rmar_2587	1.638e-19	98.0	COG0664@1|root,COG0664@2|Bacteria	2|Bacteria	T	cyclic nucleotide binding	crp	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	cNMP_binding
HKD3_k127_124533_13	497965.Cyan7822_5426	6.408e-21	94.0	COG1409@1|root,COG1409@2|Bacteria	2|Bacteria	S	acid phosphatase activity	phoA	-	3.1.3.1	ko:K01077	ko00730,ko00790,ko01100,ko02020,map00730,map00790,map01100,map02020	M00126	R02135,R04620	RC00017	ko00000,ko00001,ko00002,ko00537,ko01000,ko04147	-	-	-	F5_F8_type_C,Metallophos
HKD3_k127_1246350_0	522306.CAP2UW1_0141	3.195e-206	652.0	COG1752@1|root,COG1752@2|Bacteria,1MUI6@1224|Proteobacteria,2VHA3@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Phospholipase, patatin family	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
HKD3_k127_1246350_1	530564.Psta_3485	9.065e-73	255.0	COG0671@1|root,COG0671@2|Bacteria,2IZAS@203682|Planctomycetes	203682|Planctomycetes	I	LssY C-terminus	-	-	-	-	-	-	-	-	-	-	-	-	LssY_C
HKD3_k127_1246350_2	1500897.JQNA01000001_gene5428	0.0002902	47.0	COG2358@1|root,COG2358@2|Bacteria,1PNJV@1224|Proteobacteria,2VI8H@28216|Betaproteobacteria,1K1DT@119060|Burkholderiaceae	28216|Betaproteobacteria	S	ABC transporter substrate-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	NMT1_3
HKD3_k127_1254324_5	388051.AUFE01000079_gene2328	2.601e-56	205.0	COG3565@1|root,COG3565@2|Bacteria,1RD7C@1224|Proteobacteria,2VRG8@28216|Betaproteobacteria,1K76N@119060|Burkholderiaceae	28216|Betaproteobacteria	S	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	ko:K06991	-	-	-	-	ko00000	-	-	-	Glyoxalase
HKD3_k127_1254324_7	1163407.UU7_10740	3.176e-20	94.0	2CDT8@1|root,33C3R@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_1254324_2	94624.Bpet0411	2.064e-129	422.0	COG0600@1|root,COG0600@2|Bacteria,1PC26@1224|Proteobacteria,2VJ97@28216|Betaproteobacteria,3T3G2@506|Alcaligenaceae	28216|Betaproteobacteria	P	ABC-type nitrate sulfonate bicarbonate transport system permease component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
HKD3_k127_1254324_3	1235457.C404_01985	1.676e-120	394.0	COG1116@1|root,COG1116@2|Bacteria,1MUYG@1224|Proteobacteria,2VHDU@28216|Betaproteobacteria,1K34B@119060|Burkholderiaceae	28216|Betaproteobacteria	P	abc transporter	-	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
HKD3_k127_1254324_4	1121930.AQXG01000001_gene1099	1.625e-97	344.0	COG1171@1|root,COG1171@2|Bacteria,4NEY2@976|Bacteroidetes,1IUV5@117747|Sphingobacteriia	976|Bacteroidetes	E	Pyridoxal-phosphate dependent enzyme	ilvA	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HKD3_k127_1254324_1	204773.HEAR3326	6.361e-143	463.0	COG0715@1|root,COG0715@2|Bacteria,1MWJF@1224|Proteobacteria,2VKMA@28216|Betaproteobacteria,473SN@75682|Oxalobacteraceae	28216|Betaproteobacteria	P	ABC-type nitrate sulfonate bicarbonate transport system, periplasmic component	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1_2
HKD3_k127_1254324_6	1286631.X805_01660	3.447e-21	107.0	COG1653@1|root,COG1653@2|Bacteria,1R5TB@1224|Proteobacteria,2VXNU@28216|Betaproteobacteria,1KN77@119065|unclassified Burkholderiales	28216|Betaproteobacteria	G	Domain of unknown function (DUF4397)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4397
HKD3_k127_1254324_0	543728.Vapar_3819	7.825e-227	708.0	COG2721@1|root,COG2721@2|Bacteria,1MU9V@1224|Proteobacteria,2VK3Y@28216|Betaproteobacteria,4AGID@80864|Comamonadaceae	28216|Betaproteobacteria	G	PFAM D-galactarate dehydratase Altronate hydrolase domain protein	-	-	4.4.1.24	ko:K16846	ko00270,map00270	-	R07633	RC01785	ko00000,ko00001,ko01000	-	-	-	GD_AH_C
HKD3_k127_127469_10	1276756.AUEX01000007_gene1382	2.701e-34	135.0	COG1595@1|root,COG1595@2|Bacteria,1MX7T@1224|Proteobacteria,2VR5K@28216|Betaproteobacteria	28216|Betaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD3_k127_127469_6	1276756.AUEX01000007_gene1381	2.053e-66	233.0	COG1633@1|root,COG1633@2|Bacteria,1R5K9@1224|Proteobacteria,2VPGA@28216|Betaproteobacteria,4AD2K@80864|Comamonadaceae	28216|Betaproteobacteria	S	Domain of unknown function (DUF4439)	-	-	-	-	-	-	-	-	-	-	-	-	Ferritin_2
HKD3_k127_127469_8	596154.Alide2_3820	4.326e-46	169.0	COG3474@1|root,COG3474@2|Bacteria,1RJS5@1224|Proteobacteria,2WEPN@28216|Betaproteobacteria,4AEMS@80864|Comamonadaceae	28216|Betaproteobacteria	C	PFAM Cytochrome c, class I	-	-	-	ko:K08738	ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	3.D.4.6	-	-	Cytochrom_C
HKD3_k127_127469_1	338969.Rfer_4134	7.76e-177	563.0	COG1858@1|root,COG1858@2|Bacteria,1N4E1@1224|Proteobacteria,2VVJQ@28216|Betaproteobacteria,4AJBC@80864|Comamonadaceae	28216|Betaproteobacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C
HKD3_k127_127469_9	580332.Slit_2763	1.317e-45	175.0	COG3219@1|root,COG3219@2|Bacteria,1QAP4@1224|Proteobacteria,2VR01@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Putative DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF2063
HKD3_k127_127469_3	1500897.JQNA01000002_gene4205	1.509e-106	355.0	COG3220@1|root,COG3220@2|Bacteria,1MURE@1224|Proteobacteria,2VKD3@28216|Betaproteobacteria,1K0J2@119060|Burkholderiaceae	28216|Betaproteobacteria	S	belongs to the UPF0276 family	-	-	-	ko:K09930	-	-	-	-	ko00000	-	-	-	DUF2063,DUF692
HKD3_k127_127469_12	243365.CV_3512	1.174e-24	110.0	COG5572@1|root,COG5572@2|Bacteria,1MZ6Q@1224|Proteobacteria,2VWC8@28216|Betaproteobacteria,2KRX5@206351|Neisseriales	206351|Neisseriales	S	Predicted integral membrane protein (DUF2282)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2282
HKD3_k127_127469_4	251221.35211500	2.536e-100	337.0	COG0668@1|root,COG0668@2|Bacteria,1G1I3@1117|Cyanobacteria	1117|Cyanobacteria	M	mechanosensitive ion channel	-	-	-	ko:K03442	-	-	-	-	ko00000,ko02000	1.A.23.2	-	-	MS_channel
HKD3_k127_127469_11	365046.Rta_17100	2.813e-25	112.0	COG3753@1|root,COG3753@2|Bacteria,1N7FF@1224|Proteobacteria,2VYJW@28216|Betaproteobacteria,4AG0Q@80864|Comamonadaceae	28216|Betaproteobacteria	S	Bacterial protein of unknown function (DUF937)	-	-	-	-	-	-	-	-	-	-	-	-	DUF937
HKD3_k127_127469_7	69279.BG36_19110	1.241e-60	220.0	COG0583@1|root,COG0583@2|Bacteria,1R6BU@1224|Proteobacteria,2U3I2@28211|Alphaproteobacteria,43M6I@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	K	LysR substrate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HKD3_k127_127469_0	69279.BG36_19095	2.901e-251	789.0	COG3119@1|root,COG3119@2|Bacteria,1MV92@1224|Proteobacteria,2TTXG@28211|Alphaproteobacteria,43K0Q@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	P	Sulfatase	atsA	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
HKD3_k127_127469_5	1532558.JL39_01860	6.172e-97	333.0	COG1653@1|root,COG1653@2|Bacteria,1R877@1224|Proteobacteria,2VFF6@28211|Alphaproteobacteria,4BN97@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1
HKD3_k127_127469_2	1040987.AZUY01000031_gene4598	3.164e-117	387.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2TQQJ@28211|Alphaproteobacteria,43JHG@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	ABC transporter	malK	-	-	ko:K10112	ko02010,map02010	M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1	-	-	ABC_tran,TOBE_2
HKD3_k127_127469_13	1122214.AQWH01000008_gene1430	0.0002096	46.0	COG1175@1|root,COG1175@2|Bacteria,1MWB7@1224|Proteobacteria,2TQZY@28211|Alphaproteobacteria,2PJT4@255475|Aurantimonadaceae	28211|Alphaproteobacteria	U	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
HKD3_k127_1276613_0	1288494.EBAPG3_6760	2.563e-295	920.0	COG1674@1|root,COG1674@2|Bacteria,1MVPI@1224|Proteobacteria,2VHJV@28216|Betaproteobacteria,372D7@32003|Nitrosomonadales	28216|Betaproteobacteria	D	PFAM cell divisionFtsK SpoIIIE	ftsK	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
HKD3_k127_1276613_2	1000565.METUNv1_02871	1.691e-33	136.0	COG2834@1|root,COG2834@2|Bacteria,1PXDV@1224|Proteobacteria,2VNNH@28216|Betaproteobacteria,2KWH0@206389|Rhodocyclales	206389|Rhodocyclales	M	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)	lolA	-	-	ko:K03634	-	-	-	-	ko00000	-	-	-	LolA
HKD3_k127_1276613_3	1304883.KI912532_gene2952	4.082e-19	88.0	COG2834@1|root,COG2834@2|Bacteria,1PXDV@1224|Proteobacteria,2VNNH@28216|Betaproteobacteria,2KWH0@206389|Rhodocyclales	206389|Rhodocyclales	M	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)	lolA	-	-	ko:K03634	-	-	-	-	ko00000	-	-	-	LolA
HKD3_k127_1276613_1	1205680.CAKO01000040_gene673	5.922e-83	283.0	COG0584@1|root,COG0584@2|Bacteria,1MW6Z@1224|Proteobacteria,2V78M@28211|Alphaproteobacteria,2JSGH@204441|Rhodospirillales	204441|Rhodospirillales	C	Glycerophosphoryl diester phosphodiesterase family	-	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD
HKD3_k127_1278556_11	1134445.AJJM01000089_gene1020	4.071e-13	83.0	COG2020@1|root,COG2020@2|Bacteria,2IIDW@201174|Actinobacteria	201174|Actinobacteria	O	Phospholipid methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
HKD3_k127_1278556_10	1000565.METUNv1_03657	1.441e-35	149.0	COG5652@1|root,COG5652@2|Bacteria,1PJUW@1224|Proteobacteria,2VHEZ@28216|Betaproteobacteria,2KW9S@206389|Rhodocyclales	206389|Rhodocyclales	S	VanZ like family	-	-	-	-	-	-	-	-	-	-	-	-	VanZ
HKD3_k127_1278556_9	983917.RGE_30170	7.907e-37	147.0	COG1246@1|root,COG1246@2|Bacteria	2|Bacteria	E	Belongs to the acetyltransferase family. ArgA subfamily	-	-	-	ko:K03830	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_1,Acetyltransf_10,YiiD_C
HKD3_k127_1278556_2	1005048.CFU_0650	7.725e-159	534.0	COG0687@1|root,COG0687@2|Bacteria,1MUYW@1224|Proteobacteria,2VJDV@28216|Betaproteobacteria,472IF@75682|Oxalobacteraceae	28216|Betaproteobacteria	E	Required for the activity of the bacterial periplasmic transport system of putrescine	potD	-	-	ko:K02055,ko:K11069,ko:K11073	ko02010,ko02024,map02010,map02024	M00193,M00299,M00300	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11,3.A.1.11.1,3.A.1.11.2	-	-	SBP_bac_6,SBP_bac_8
HKD3_k127_1278556_5	1005048.CFU_0649	1.518e-115	376.0	COG1177@1|root,COG1177@2|Bacteria,1MVC5@1224|Proteobacteria,2VHYY@28216|Betaproteobacteria,473TP@75682|Oxalobacteraceae	28216|Betaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	potC	-	-	ko:K11070,ko:K11074	ko02010,map02010	M00299,M00300	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.1,3.A.1.11.2	-	-	BPD_transp_1
HKD3_k127_1278556_4	204773.HEAR2850	5.483e-135	437.0	COG1176@1|root,COG1176@2|Bacteria,1MVGM@1224|Proteobacteria,2VHYC@28216|Betaproteobacteria,473P7@75682|Oxalobacteraceae	28216|Betaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	potB	-	-	ko:K02054,ko:K11071,ko:K11075	ko02010,ko02024,map02010,map02024	M00193,M00299,M00300	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11,3.A.1.11.1,3.A.1.11.2	-	-	BPD_transp_1
HKD3_k127_1278556_3	1005048.CFU_0647	7.778e-153	524.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2VHEJ@28216|Betaproteobacteria,472GH@75682|Oxalobacteraceae	28216|Betaproteobacteria	E	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system	potA	-	3.6.3.31	ko:K11072	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.11.1	-	-	ABC_tran,TOBE_2
HKD3_k127_1278556_0	1121035.AUCH01000006_gene631	3.595e-211	667.0	COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,2VJ07@28216|Betaproteobacteria,2KVNA@206389|Rhodocyclales	206389|Rhodocyclales	H	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis	ubiB	-	-	ko:K03688	-	-	-	-	ko00000	-	-	-	ABC1
HKD3_k127_1278556_12	762376.AXYL_00499	4.935e-12	76.0	COG3165@1|root,COG3165@2|Bacteria,1N314@1224|Proteobacteria,2VU2B@28216|Betaproteobacteria,3T48H@506|Alcaligenaceae	28216|Betaproteobacteria	S	SCP-2 sterol transfer family	-	-	-	ko:K03690	-	-	-	-	ko00000	-	-	-	SCP2
HKD3_k127_1278556_8	640081.Dsui_0860	6.933e-48	195.0	COG4395@1|root,COG4395@2|Bacteria,1NSUG@1224|Proteobacteria,2VNS7@28216|Betaproteobacteria,2KV4Q@206389|Rhodocyclales	206389|Rhodocyclales	S	import inner membrane translocase subunit Tim44	-	-	-	-	-	-	-	-	-	-	-	-	Tim44
HKD3_k127_1278556_6	1437824.BN940_03456	1.838e-99	330.0	COG0500@1|root,COG2226@2|Bacteria,1MX8I@1224|Proteobacteria,2VHBM@28216|Betaproteobacteria,3T209@506|Alcaligenaceae	28216|Betaproteobacteria	H	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2)	ubiE	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Ubie_methyltran
HKD3_k127_1278556_7	62928.azo0163	1.403e-55	199.0	COG3536@1|root,COG3536@2|Bacteria,1MZ5M@1224|Proteobacteria,2VR9K@28216|Betaproteobacteria,2KWB0@206389|Rhodocyclales	206389|Rhodocyclales	S	Protein of unknown function (DUF971)	-	-	-	-	-	-	-	-	-	-	-	-	DUF971
HKD3_k127_1278556_1	640081.Dsui_0605	1.506e-160	509.0	COG5008@1|root,COG5008@2|Bacteria,1QTTX@1224|Proteobacteria,2VIWS@28216|Betaproteobacteria,2KU9J@206389|Rhodocyclales	206389|Rhodocyclales	NU	twitching motility protein	-	-	-	ko:K02670	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
HKD3_k127_130180_27	1260251.SPISAL_02610	1.663e-24	106.0	COG0454@1|root,COG0456@2|Bacteria,1RIE6@1224|Proteobacteria,1S9G0@1236|Gammaproteobacteria,1WYDP@135613|Chromatiales	135613|Chromatiales	K	Ribosomal-protein-alanine acetyltransferase	-	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1
HKD3_k127_130180_19	1266925.JHVX01000006_gene2144	4.004e-75	264.0	COG1573@1|root,COG1573@2|Bacteria,1MWX1@1224|Proteobacteria,2VPZQ@28216|Betaproteobacteria,37236@32003|Nitrosomonadales	28216|Betaproteobacteria	L	TIGRFAM Phage SPO1 DNA polymerase-related protein	dpo	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
HKD3_k127_130180_15	316056.RPC_1333	1.486e-87	296.0	COG1704@1|root,COG1704@2|Bacteria,1MVH0@1224|Proteobacteria,2TRJR@28211|Alphaproteobacteria,3JTSH@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	LemA family	lemA	-	-	ko:K03744	-	-	-	-	ko00000	-	-	-	LemA
HKD3_k127_130180_23	1122603.ATVI01000001_gene1895	2.321e-59	218.0	COG1512@1|root,COG1512@2|Bacteria,1PB41@1224|Proteobacteria,1S38U@1236|Gammaproteobacteria,1XC3C@135614|Xanthomonadales	135614|Xanthomonadales	S	TPM domain	-	-	-	ko:K06872	-	-	-	-	ko00000	-	-	-	TPM_phosphatase
HKD3_k127_130180_25	595537.Varpa_5494	8.237e-47	173.0	COG3762@1|root,COG3762@2|Bacteria,1R61N@1224|Proteobacteria,2VRJE@28216|Betaproteobacteria,4AE80@80864|Comamonadaceae	28216|Betaproteobacteria	S	TPM domain	-	-	-	-	-	-	-	-	-	-	-	-	TPM_phosphatase
HKD3_k127_130180_1	323848.Nmul_A2116	4.104e-176	562.0	COG0477@1|root,COG2814@2|Bacteria,1QTWR@1224|Proteobacteria,2VIC5@28216|Betaproteobacteria,37237@32003|Nitrosomonadales	28216|Betaproteobacteria	EGP	PFAM Major facilitator superfamily	lplT	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD3_k127_130180_7	1163617.SCD_n01786	1.321e-113	393.0	COG0787@1|root,COG0787@2|Bacteria,1MV0Q@1224|Proteobacteria,2VIXM@28216|Betaproteobacteria	28216|Betaproteobacteria	E	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids	alr	-	5.1.1.1	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	-	R00401	RC00285	ko00000,ko00001,ko01000,ko01011	-	-	-	Ala_racemase_C,Ala_racemase_N
HKD3_k127_130180_5	1163617.SCD_n01041	1.856e-142	458.0	COG0451@1|root,COG0451@2|Bacteria,1MVE4@1224|Proteobacteria,2VH69@28216|Betaproteobacteria	28216|Betaproteobacteria	GM	Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose	hldD	-	5.1.3.20	ko:K03274	ko00540,ko01100,map00540,map01100	M00064	R05176	RC01291	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Epimerase
HKD3_k127_130180_29	1051985.l11_18250	1.798e-21	108.0	COG1555@1|root,COG1555@2|Bacteria,1N6Q3@1224|Proteobacteria	1224|Proteobacteria	L	Competence protein ComEA	comEA	GO:0005575,GO:0005623,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464	-	ko:K02237	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	HHH_3
HKD3_k127_130180_30	1051985.l11_18250	1.195e-20	102.0	COG1555@1|root,COG1555@2|Bacteria,1N6Q3@1224|Proteobacteria	1224|Proteobacteria	L	Competence protein ComEA	comEA	GO:0005575,GO:0005623,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464	-	ko:K02237	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	HHH_3
HKD3_k127_130180_4	1304883.KI912532_gene2961	4.66e-149	477.0	COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,2VH7B@28216|Betaproteobacteria,2KV1N@206389|Rhodocyclales	206389|Rhodocyclales	E	Belongs to the cysteine synthase cystathionine beta- synthase family	cysM	-	2.5.1.47	ko:K12339	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03132,R03601,R04859	RC00020,RC02814,RC02821,RC02876	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HKD3_k127_130180_10	1123392.AQWL01000011_gene2254	1.871e-103	346.0	COG3298@1|root,COG3298@2|Bacteria,1MVZJ@1224|Proteobacteria,2VISP@28216|Betaproteobacteria,1KRCC@119069|Hydrogenophilales	119069|Hydrogenophilales	L	Predicted 3'-5' exonuclease related to the exonuclease domain of PolB	-	-	-	ko:K07501	-	-	-	-	ko00000	-	-	-	DNA_pol_B_exo2
HKD3_k127_130180_9	1268622.AVS7_03058	7.768e-104	346.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VJCY@28216|Betaproteobacteria,4ABM4@80864|Comamonadaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HKD3_k127_130180_12	1424334.W822_16125	2.438e-96	342.0	COG4948@1|root,COG4948@2|Bacteria,1PK0G@1224|Proteobacteria,2W8C4@28216|Betaproteobacteria,3T6J4@506|Alcaligenaceae	28216|Betaproteobacteria	M	Mandelate racemase / muconate lactonizing enzyme, C-terminal domain	-	-	4.2.1.6	ko:K01684	ko00052,ko01100,ko01120,map00052,map01100,map01120	M00552	R03033	RC00543	ko00000,ko00001,ko00002,ko01000	-	-	-	MR_MLE_C
HKD3_k127_130180_13	1366050.N234_15680	4.31e-94	317.0	COG0384@1|root,COG0384@2|Bacteria,1MUAS@1224|Proteobacteria,2VHM0@28216|Betaproteobacteria,1K3NS@119060|Burkholderiaceae	28216|Betaproteobacteria	S	phenazine biosynthesis protein PhzF family	phzF_1	-	-	-	-	-	-	-	-	-	-	-	PhzC-PhzF
HKD3_k127_130180_8	1123392.AQWL01000008_gene1266	9.66e-107	367.0	COG2603@1|root,COG2603@2|Bacteria,1N4T5@1224|Proteobacteria,2VIMH@28216|Betaproteobacteria,1KSVD@119069|Hydrogenophilales	119069|Hydrogenophilales	H	Rhodanese Homology Domain	-	-	-	ko:K06917	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Rhodanese
HKD3_k127_130180_22	1112217.PPL19_10997	6.17e-60	228.0	COG2755@1|root,COG2755@2|Bacteria,1RCXZ@1224|Proteobacteria,1S3QU@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	COG2755 Lysophospholipase L1 and related esterases	tesA	GO:0003674,GO:0003824,GO:0004620,GO:0004622,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0016289,GO:0016290,GO:0016298,GO:0016787,GO:0016788,GO:0016790,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0042802,GO:0043170,GO:0044238,GO:0044464,GO:0047617,GO:0052689,GO:0071704,GO:0140096,GO:1901564	3.1.1.5	ko:K10804	ko01040,map01040	-	-	-	ko00000,ko00001,ko01000,ko01004	-	-	iECED1_1282.ECED1_0521,iLF82_1304.LF82_2242,iNRG857_1313.NRG857_02365	Lipase_GDSL_2
HKD3_k127_130180_14	261292.Nit79A3_1318	4.934e-89	300.0	COG4181@1|root,COG4181@2|Bacteria,1MXG9@1224|Proteobacteria,2VI54@28216|Betaproteobacteria,3722E@32003|Nitrosomonadales	28216|Betaproteobacteria	Q	ABC transporter	lolD	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD3_k127_130180_0	1288494.EBAPG3_22770	4.077e-219	709.0	COG3127@1|root,COG3127@2|Bacteria,1MU9R@1224|Proteobacteria,2VHHQ@28216|Betaproteobacteria,37208@32003|Nitrosomonadales	28216|Betaproteobacteria	Q	ABC-type transport system involved in lysophospholipase L1 biosynthesis permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HKD3_k127_130180_26	1265502.KB905933_gene2105	5.389e-39	169.0	COG2346@1|root,COG2346@2|Bacteria,1RH21@1224|Proteobacteria,2VSUJ@28216|Betaproteobacteria,4ADYV@80864|Comamonadaceae	28216|Betaproteobacteria	S	PFAM globin	yjbI	-	-	ko:K06886	-	-	-	-	ko00000	-	-	-	Bac_globin
HKD3_k127_130180_11	398527.Bphyt_5921	2.138e-96	328.0	COG0061@1|root,COG3199@1|root,COG0061@2|Bacteria,COG3199@2|Bacteria,1R9QB@1224|Proteobacteria,2VKMP@28216|Betaproteobacteria,1K5YD@119060|Burkholderiaceae	28216|Betaproteobacteria	H	PFAM ATP-NAD AcoX kinase	acoX	-	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	NAD_kinase
HKD3_k127_130180_3	748247.AZKH_3815	4.8e-162	529.0	COG1071@1|root,COG1071@2|Bacteria,1MU5R@1224|Proteobacteria,2VN57@28216|Betaproteobacteria,2KYIV@206389|Rhodocyclales	206389|Rhodocyclales	C	COG1071 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit	-	-	-	ko:K21416	-	-	-	-	ko00000,ko01000	-	-	-	E1_dh
HKD3_k127_130180_2	640511.BC1002_6670	5.227e-173	547.0	COG0022@1|root,COG0022@2|Bacteria,1R8KB@1224|Proteobacteria,2VKQ0@28216|Betaproteobacteria,1K3BP@119060|Burkholderiaceae	28216|Betaproteobacteria	C	PFAM Transketolase central region	acoB	-	-	ko:K21417	-	-	-	-	ko00000,ko01000	-	-	-	Transket_pyr,Transketolase_C
HKD3_k127_130180_6	1121127.JAFA01000011_gene3884	1.525e-128	422.0	COG0508@1|root,COG0596@1|root,COG0508@2|Bacteria,COG0596@2|Bacteria,1NU1Q@1224|Proteobacteria,2VNCN@28216|Betaproteobacteria,1K2C3@119060|Burkholderiaceae	28216|Betaproteobacteria	C	PFAM alpha beta hydrolase fold	acoC	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Abhydrolase_1,Abhydrolase_6,Biotin_lipoyl
HKD3_k127_130180_20	1265505.ATUG01000002_gene1661	2.746e-67	253.0	COG2145@1|root,COG2145@2|Bacteria,1MVES@1224|Proteobacteria,42PAR@68525|delta/epsilon subdivisions,2WMWU@28221|Deltaproteobacteria,2MJHN@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)	thiM	-	2.7.1.50	ko:K00878	ko00730,ko01100,map00730,map01100	M00127	R04448	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	HK
HKD3_k127_130180_24	880526.KE386488_gene1875	5.33e-57	209.0	COG0352@1|root,COG0352@2|Bacteria,4NNFB@976|Bacteroidetes,2FMPB@200643|Bacteroidia,22V9D@171550|Rikenellaceae	976|Bacteroidetes	H	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)	thiE	-	2.5.1.3	ko:K00788	ko00730,ko01100,map00730,map01100	M00127	R03223,R10712	RC00224,RC03255,RC03397	ko00000,ko00001,ko00002,ko01000	-	-	-	TMP-TENI
HKD3_k127_130180_28	640511.BC1002_1015	5.866e-23	102.0	COG4454@1|root,COG4454@2|Bacteria,1QTWM@1224|Proteobacteria,2VU87@28216|Betaproteobacteria,1K8D0@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Cupredoxin-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupredoxin_1
HKD3_k127_130180_16	398527.Bphyt_1399	2.067e-87	298.0	COG0672@1|root,COG0672@2|Bacteria,1MX1M@1224|Proteobacteria,2VHEE@28216|Betaproteobacteria,1K21N@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Iron permease	efeU	-	-	ko:K07243	-	-	-	-	ko00000,ko02000	2.A.108.1,2.A.108.2	-	-	FTR1
HKD3_k127_130180_21	246197.MXAN_6826	1.18e-63	233.0	COG1668@1|root,COG1668@2|Bacteria,1R3RG@1224|Proteobacteria,43B64@68525|delta/epsilon subdivisions,2X6JN@28221|Deltaproteobacteria,2YVQ4@29|Myxococcales	28221|Deltaproteobacteria	CP	sodium ABC transporter, permease	-	-	-	ko:K09696	ko02010,ko02020,map02010,map02020	M00253	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.115	-	-	ABC2_membrane_2,Abi
HKD3_k127_130180_18	1500893.JQNB01000001_gene1219	5.417e-85	291.0	COG4555@1|root,COG4555@2|Bacteria,1QU2T@1224|Proteobacteria,1T1NM@1236|Gammaproteobacteria,1XD4Y@135614|Xanthomonadales	135614|Xanthomonadales	CP	abc transporter atp-binding protein	natA	-	3.6.3.7	ko:K09697	ko02010,ko02020,map02010,map02020	M00253	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.115	-	-	ABC_tran
HKD3_k127_130180_17	483219.LILAB_12320	3.168e-86	306.0	COG0596@1|root,COG0596@2|Bacteria,1R6KU@1224|Proteobacteria,438C4@68525|delta/epsilon subdivisions,2WYM4@28221|Deltaproteobacteria,2YWIJ@29|Myxococcales	28221|Deltaproteobacteria	S	hydrolases or acyltransferases (alpha beta hydrolase superfamily)	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
HKD3_k127_130180_31	1123073.KB899241_gene2107	2.698e-17	82.0	COG3483@1|root,COG3483@2|Bacteria,1MW68@1224|Proteobacteria,1RXYM@1236|Gammaproteobacteria,1X3GY@135614|Xanthomonadales	135614|Xanthomonadales	E	Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety	kynA	GO:0003674,GO:0003824,GO:0004833,GO:0005488,GO:0006082,GO:0006084,GO:0006139,GO:0006163,GO:0006520,GO:0006568,GO:0006569,GO:0006576,GO:0006586,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009072,GO:0009074,GO:0009117,GO:0009150,GO:0009259,GO:0009308,GO:0009310,GO:0009987,GO:0016043,GO:0016054,GO:0016491,GO:0016701,GO:0016702,GO:0019439,GO:0019441,GO:0019442,GO:0019637,GO:0019693,GO:0019752,GO:0020037,GO:0022607,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0035383,GO:0042180,GO:0042402,GO:0042430,GO:0042436,GO:0042537,GO:0043436,GO:0043603,GO:0043933,GO:0044085,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0046218,GO:0046395,GO:0046483,GO:0046700,GO:0046906,GO:0048037,GO:0051186,GO:0051213,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055086,GO:0055114,GO:0065003,GO:0070189,GO:0071704,GO:0071840,GO:0072521,GO:0097159,GO:1901135,GO:1901360,GO:1901361,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	1.13.11.11	ko:K00453	ko00380,ko01100,map00380,map01100	M00038	R00678	RC00356	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_dioxygenase
HKD3_k127_1311593_0	1123354.AUDR01000003_gene1561	1.304e-94	315.0	COG0079@1|root,COG0079@2|Bacteria,1MW7I@1224|Proteobacteria,2VIPQ@28216|Betaproteobacteria,1KS3I@119069|Hydrogenophilales	119069|Hydrogenophilales	E	Aminotransferase class I and II	-	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
HKD3_k127_1311593_1	269482.Bcep1808_0965	8.52e-84	290.0	COG0287@1|root,COG0287@2|Bacteria,1QTZA@1224|Proteobacteria,2VIS1@28216|Betaproteobacteria,1K2DC@119060|Burkholderiaceae	28216|Betaproteobacteria	E	prephenate dehydrogenase	tyrA	-	1.3.1.12	ko:K04517	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	M00025	R01728	RC00125	ko00000,ko00001,ko00002,ko01000	-	-	-	PDH
HKD3_k127_1311593_2	93220.LV28_20870	9.507e-47	173.0	COG0128@1|root,COG0128@2|Bacteria,1MWMK@1224|Proteobacteria,2VGZF@28216|Betaproteobacteria,1K0P7@119060|Burkholderiaceae	28216|Betaproteobacteria	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	-	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytidylate_kin,EPSP_synthase
HKD3_k127_1324619_2	742823.HMPREF9465_00291	1.352e-29	118.0	COG0333@1|root,COG0333@2|Bacteria,1N6RF@1224|Proteobacteria,2VVP5@28216|Betaproteobacteria,4PRAU@995019|Sutterellaceae	28216|Betaproteobacteria	J	Ribosomal L32p protein family	rpmF	-	-	ko:K02911	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_L32p
HKD3_k127_1324619_1	196367.JNFG01000200_gene3113	1.811e-130	429.0	COG0416@1|root,COG0416@2|Bacteria,1MVM3@1224|Proteobacteria,2VI25@28216|Betaproteobacteria,1K229@119060|Burkholderiaceae	28216|Betaproteobacteria	I	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA	plsX	-	2.3.1.15	ko:K03621	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FA_synthesis
HKD3_k127_1324619_0	511.JT27_16270	4.686e-133	447.0	COG0332@1|root,COG0332@2|Bacteria,1MU9N@1224|Proteobacteria,2VI2A@28216|Betaproteobacteria,3T29J@506|Alcaligenaceae	28216|Betaproteobacteria	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	fabH	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
HKD3_k127_1324619_3	94624.Bpet1754	5.163e-07	55.0	COG0331@1|root,COG0331@2|Bacteria,1MV6N@1224|Proteobacteria,2VJF7@28216|Betaproteobacteria,3T1JV@506|Alcaligenaceae	28216|Betaproteobacteria	I	Malonyl CoA-acyl carrier protein transacylase	fabD	GO:0003674,GO:0003824,GO:0004312,GO:0004314,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016417,GO:0016419,GO:0016420,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901576	2.3.1.39	ko:K00645,ko:K15355	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	M00082	R01626,R11671	RC00004,RC00039,RC02727	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyl_transf_1
HKD3_k127_1334530_5	1123504.JQKD01000006_gene1432	3.214e-130	428.0	COG1071@1|root,COG1071@2|Bacteria,1MU5R@1224|Proteobacteria,2VIIQ@28216|Betaproteobacteria,4ADS6@80864|Comamonadaceae	28216|Betaproteobacteria	C	dehydrogenase, E1 component	pdhA	-	1.2.4.1	ko:K00161,ko:K21416	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
HKD3_k127_1334530_6	543728.Vapar_5031	2.21e-127	433.0	COG0022@1|root,COG0022@2|Bacteria,1R8KB@1224|Proteobacteria,2VKQ0@28216|Betaproteobacteria,4ACTU@80864|Comamonadaceae	28216|Betaproteobacteria	C	PFAM Transketolase central region	-	-	1.2.4.1	ko:K00162,ko:K21417	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
HKD3_k127_1334530_2	522306.CAP2UW1_3685	2.82e-191	600.0	COG1638@1|root,COG1638@2|Bacteria,1MVHC@1224|Proteobacteria,2VM68@28216|Betaproteobacteria,1KQFH@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	G	Carbohydrate transport and metabolism	yiaO_1	-	-	ko:K21395	-	-	-	-	ko00000,ko02000	2.A.56.1	-	-	DctP
HKD3_k127_1334530_8	522306.CAP2UW1_3686	3.482e-68	252.0	COG3090@1|root,COG3090@2|Bacteria,1RDY3@1224|Proteobacteria,2VRWQ@28216|Betaproteobacteria	28216|Betaproteobacteria	G	Tripartite ATP-independent periplasmic transporter dctq component	yiaM_2	-	-	-	-	-	-	-	-	-	-	-	DctQ
HKD3_k127_1334530_1	522306.CAP2UW1_3687	7.264e-219	685.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2VHJP@28216|Betaproteobacteria,1KQ6J@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	G	Tripartite ATP-independent periplasmic transporter, DctM component	-	-	-	ko:K11690	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.56.1	-	-	DctM
HKD3_k127_1334530_10	1210884.HG799467_gene13467	5.945e-06	49.0	COG2987@1|root,COG2987@2|Bacteria,2IYV3@203682|Planctomycetes	203682|Planctomycetes	E	Urocanase C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Urocanase,Urocanase_C,Urocanase_N
HKD3_k127_1334530_0	983917.RGE_38100	2.63e-279	895.0	COG2987@1|root,COG2987@2|Bacteria,1MU4W@1224|Proteobacteria,2VK3E@28216|Betaproteobacteria,1KMZR@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate	hutU	-	4.2.1.49	ko:K01712	ko00340,ko01100,map00340,map01100	M00045	R02914	RC00804	ko00000,ko00001,ko00002,ko01000	-	-	-	Urocanase,Urocanase_C,Urocanase_N
HKD3_k127_1334530_3	1415755.JQLV01000001_gene1900	3.12e-179	577.0	COG2986@1|root,COG2986@2|Bacteria,1MU6K@1224|Proteobacteria,1RP02@1236|Gammaproteobacteria,1XH8F@135619|Oceanospirillales	135619|Oceanospirillales	E	Catalyzes the degradation of histidine to urocanate and ammmonia	hutH	-	4.3.1.3	ko:K01745	ko00340,ko01100,map00340,map01100	M00045	R01168	RC00361	ko00000,ko00001,ko00002,ko01000	-	-	-	Lyase_aromatic
HKD3_k127_1334530_7	640081.Dsui_3387	1.628e-70	261.0	COG3447@1|root,COG4191@1|root,COG3447@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2VJUT@28216|Betaproteobacteria,2KYIQ@206389|Rhodocyclales	206389|Rhodocyclales	T	MASE1	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,MASE1
HKD3_k127_1334530_9	338969.Rfer_3082	9.758e-47	183.0	COG4566@1|root,COG4566@2|Bacteria,1N6WR@1224|Proteobacteria,2VM61@28216|Betaproteobacteria,4A9SU@80864|Comamonadaceae	28216|Betaproteobacteria	K	Two component transcriptional regulator, LuxR family	-	-	-	ko:K13041	ko02020,map02020	M00514	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	GerE,Response_reg
HKD3_k127_1334530_4	1121035.AUCH01000021_gene2711	5.238e-152	502.0	COG0249@1|root,COG0249@2|Bacteria,1MUGX@1224|Proteobacteria,2VI3Z@28216|Betaproteobacteria,2KV02@206389|Rhodocyclales	206389|Rhodocyclales	L	that it carries out the mismatch recognition step. This protein has a weak ATPase activity	mutS	-	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
HKD3_k127_1358856_0	1123487.KB892863_gene1959	1.241e-208	667.0	COG1643@1|root,COG1643@2|Bacteria,1MUEQ@1224|Proteobacteria,2VI3R@28216|Betaproteobacteria,2KUB1@206389|Rhodocyclales	206389|Rhodocyclales	L	Helicase associated domain (HA2)  Add an annotation	hrpA	-	3.6.4.13	ko:K03578	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,DUF3418,HA2,Helicase_C,OB_NTP_bind
HKD3_k127_1358856_2	983917.RGE_36860	9.221e-192	619.0	COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,2VHCV@28216|Betaproteobacteria,1KJIQ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	ABC-type dipeptide transport system, periplasmic component	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
HKD3_k127_1358856_1	864051.BurJ1DRAFT_0131	2.08e-207	695.0	COG1404@1|root,COG1404@2|Bacteria,1RCVT@1224|Proteobacteria	1224|Proteobacteria	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
HKD3_k127_1358856_3	1408473.JHXO01000001_gene2299	5.588e-149	511.0	COG1266@1|root,COG1266@2|Bacteria	2|Bacteria	V	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
HKD3_k127_1382149_7	264198.Reut_B4987	2.657e-78	265.0	COG4447@1|root,COG4447@2|Bacteria,1ND1J@1224|Proteobacteria,2VMA5@28216|Betaproteobacteria,1K2TY@119060|Burkholderiaceae	28216|Betaproteobacteria	S	protein related to plant photosystem II stability assembly factor	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_1382149_8	1175306.GWL_44870	1.062e-76	260.0	COG0678@1|root,COG0678@2|Bacteria,1MU0H@1224|Proteobacteria,2VQDH@28216|Betaproteobacteria,4736X@75682|Oxalobacteraceae	28216|Betaproteobacteria	O	Redoxin	ahp1	-	1.11.1.15	ko:K03386	ko04214,map04214	-	-	-	ko00000,ko00001,ko01000,ko04147	-	-	-	Redoxin
HKD3_k127_1382149_5	748247.AZKH_0110	7.049e-99	332.0	COG1475@1|root,COG1475@2|Bacteria,1MW2E@1224|Proteobacteria,2VIG0@28216|Betaproteobacteria,2KU8M@206389|Rhodocyclales	206389|Rhodocyclales	K	Belongs to the ParB family	spoOJ	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
HKD3_k127_1382149_4	1121035.AUCH01000012_gene2975	6.816e-103	342.0	COG1192@1|root,COG1192@2|Bacteria,1MV43@1224|Proteobacteria,2VHNK@28216|Betaproteobacteria,2KV5R@206389|Rhodocyclales	206389|Rhodocyclales	D	involved in chromosome partitioning	-	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
HKD3_k127_1382149_9	1266925.JHVX01000008_gene371	3.829e-58	214.0	COG0357@1|root,COG0357@2|Bacteria,1MY0K@1224|Proteobacteria,2VR3B@28216|Betaproteobacteria,372DW@32003|Nitrosomonadales	28216|Betaproteobacteria	J	Specifically methylates the N7 position of guanine in position 527 of 16S rRNA	rsmG	-	2.1.1.170	ko:K03501	-	-	-	-	ko00000,ko01000,ko03009,ko03036	-	-	-	GidB
HKD3_k127_1382149_1	402626.Rpic_3523	4.335e-304	943.0	COG0445@1|root,COG0445@2|Bacteria,1MU6F@1224|Proteobacteria,2VIGG@28216|Betaproteobacteria,1K1UR@119060|Burkholderiaceae	28216|Betaproteobacteria	D	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34	gidA	-	-	ko:K03495	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko03016,ko03036	-	-	-	GIDA,GIDA_assoc
HKD3_k127_1382149_0	381666.H16_A3711	7.815e-311	983.0	COG1274@1|root,COG1274@2|Bacteria,1MX3C@1224|Proteobacteria,2VINZ@28216|Betaproteobacteria,1JZXA@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle	pckG	GO:0000003,GO:0001655,GO:0001822,GO:0001889,GO:0003006,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004457,GO:0004611,GO:0004613,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005975,GO:0005996,GO:0006006,GO:0006007,GO:0006066,GO:0006071,GO:0006082,GO:0006089,GO:0006090,GO:0006091,GO:0006094,GO:0006109,GO:0006111,GO:0006113,GO:0006139,GO:0006163,GO:0006464,GO:0006629,GO:0006631,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006735,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007028,GO:0007275,GO:0007276,GO:0007281,GO:0007292,GO:0007296,GO:0007610,GO:0008150,GO:0008152,GO:0008906,GO:0009056,GO:0009058,GO:0009062,GO:0009117,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009166,GO:0009167,GO:0009179,GO:0009185,GO:0009199,GO:0009205,GO:0009259,GO:0009410,GO:0009605,GO:0009636,GO:0009653,GO:0009719,GO:0009725,GO:0009790,GO:0009792,GO:0009887,GO:0009888,GO:0009889,GO:0009966,GO:0009967,GO:0009987,GO:0009991,GO:0010033,GO:0010243,GO:0010646,GO:0010647,GO:0010675,GO:0010906,GO:0014070,GO:0014074,GO:0015036,GO:0015980,GO:0016042,GO:0016043,GO:0016051,GO:0016052,GO:0016053,GO:0016054,GO:0016301,GO:0016310,GO:0016491,GO:0016614,GO:0016651,GO:0016667,GO:0016668,GO:0016740,GO:0016772,GO:0016773,GO:0016829,GO:0016830,GO:0016831,GO:0016999,GO:0017001,GO:0017144,GO:0018130,GO:0018991,GO:0019098,GO:0019222,GO:0019249,GO:0019318,GO:0019319,GO:0019320,GO:0019362,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019516,GO:0019538,GO:0019541,GO:0019543,GO:0019563,GO:0019626,GO:0019637,GO:0019659,GO:0019660,GO:0019661,GO:0019666,GO:0019674,GO:0019693,GO:0019751,GO:0019752,GO:0019953,GO:0022412,GO:0022414,GO:0023051,GO:0023056,GO:0030145,GO:0030154,GO:0030703,GO:0030855,GO:0031323,GO:0031667,GO:0031960,GO:0031974,GO:0032501,GO:0032502,GO:0032504,GO:0032787,GO:0032868,GO:0032869,GO:0032870,GO:0033993,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035690,GO:0036211,GO:0042221,GO:0042493,GO:0042594,GO:0042737,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043255,GO:0043412,GO:0043434,GO:0043436,GO:0043687,GO:0043900,GO:0043903,GO:0043949,GO:0043950,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044267,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0044703,GO:0045471,GO:0046031,GO:0046034,GO:0046164,GO:0046174,GO:0046364,GO:0046365,GO:0046394,GO:0046395,GO:0046434,GO:0046459,GO:0046483,GO:0046496,GO:0046677,GO:0046683,GO:0046700,GO:0046872,GO:0046914,GO:0047134,GO:0048468,GO:0048477,GO:0048513,GO:0048518,GO:0048522,GO:0048545,GO:0048562,GO:0048568,GO:0048583,GO:0048584,GO:0048598,GO:0048609,GO:0048646,GO:0048731,GO:0048732,GO:0048856,GO:0048869,GO:0050789,GO:0050792,GO:0050794,GO:0050896,GO:0051186,GO:0051384,GO:0051591,GO:0051704,GO:0051716,GO:0055086,GO:0055114,GO:0060429,GO:0061005,GO:0061008,GO:0062012,GO:0065007,GO:0070013,GO:0070365,GO:0070887,GO:0071236,GO:0071310,GO:0071361,GO:0071375,GO:0071383,GO:0071384,GO:0071385,GO:0071396,GO:0071407,GO:0071417,GO:0071466,GO:0071495,GO:0071548,GO:0071549,GO:0071704,GO:0071840,GO:0072001,GO:0072071,GO:0072329,GO:0072330,GO:0072521,GO:0072524,GO:0080090,GO:0097159,GO:0097237,GO:0097305,GO:0097306,GO:0097327,GO:1901135,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901575,GO:1901576,GO:1901615,GO:1901616,GO:1901617,GO:1901652,GO:1901653,GO:1901654,GO:1901655,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902531,GO:1902533	4.1.1.32	ko:K01596	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko03320,ko04068,ko04151,ko04152,ko04910,ko04920,ko04922,ko04931,ko04964,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map03320,map04068,map04151,map04152,map04910,map04920,map04922,map04931,map04964	M00003	R00431,R00726	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPCK_C,PEPCK_N
HKD3_k127_1382149_6	977880.RALTA_A3177	1.333e-79	284.0	COG3180@1|root,COG3180@2|Bacteria,1MUFS@1224|Proteobacteria,2VM18@28216|Betaproteobacteria,1KD4T@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Pfam:AmoA	-	-	-	ko:K07120	-	-	-	-	ko00000	-	-	-	AbrB
HKD3_k127_1382149_3	748247.AZKH_0471	3.977e-146	471.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2VHEJ@28216|Betaproteobacteria,2KW0A@206389|Rhodocyclales	206389|Rhodocyclales	E	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system	-	-	3.6.3.29,3.6.3.30	ko:K02010,ko:K02017,ko:K02052	ko02010,ko02024,map02010,map02024	M00189,M00190,M00193	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.10,3.A.1.11,3.A.1.8	-	-	ABC_tran
HKD3_k127_1382149_2	748247.AZKH_0470	9.932e-255	797.0	COG1178@1|root,COG1178@2|Bacteria,1MWEV@1224|Proteobacteria,2VP0Z@28216|Betaproteobacteria	28216|Betaproteobacteria	P	PFAM binding-protein-dependent transport systems inner membrane component	cysW_1	-	-	ko:K02011	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	BPD_transp_1
HKD3_k127_1383983_0	522306.CAP2UW1_1984	6.559e-208	684.0	COG2368@1|root,COG2368@2|Bacteria,1PEQG@1224|Proteobacteria,2VKCH@28216|Betaproteobacteria	28216|Betaproteobacteria	Q	4-hydroxyphenylacetate	-	-	1.14.14.9,4.2.1.120,5.3.3.3	ko:K00483,ko:K14534	ko00350,ko00650,ko00720,ko01100,ko01120,ko01200,ko01220,map00350,map00650,map00720,map01100,map01120,map01200,map01220	M00374,M00375	R02698,R03031,R03299,R10782	RC00046,RC01857,RC03277	ko00000,ko00001,ko00002,ko01000	-	-	-	HpaB,HpaB_N
HKD3_k127_1383983_1	1532557.JL37_26605	2.057e-184	612.0	COG0624@1|root,COG0624@2|Bacteria,1MW20@1224|Proteobacteria,2VHV4@28216|Betaproteobacteria,3T6G4@506|Alcaligenaceae	28216|Betaproteobacteria	E	Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase and related deacylases	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
HKD3_k127_1383983_2	426117.M446_5972	5.137e-151	495.0	COG0306@1|root,COG0306@2|Bacteria,1MVXK@1224|Proteobacteria,2TSYI@28211|Alphaproteobacteria,1JQX7@119045|Methylobacteriaceae	28211|Alphaproteobacteria	P	Phosphate transporter family	pit	-	-	ko:K03306	-	-	-	-	ko00000	2.A.20	-	-	PHO4
HKD3_k127_1383983_4	266834.SMc02862	2.15e-35	143.0	COG1392@1|root,COG1392@2|Bacteria,1R4SP@1224|Proteobacteria,2U5E0@28211|Alphaproteobacteria,4B9SS@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	phosphate transport regulator	MA20_27875	-	-	ko:K07220	-	-	-	-	ko00000	-	-	-	NUDIX,PhoU_div
HKD3_k127_1383983_3	1000565.METUNv1_02342	1.326e-46	175.0	COG3118@1|root,COG3118@2|Bacteria,1RHUA@1224|Proteobacteria,2VR2G@28216|Betaproteobacteria,2KWFN@206389|Rhodocyclales	206389|Rhodocyclales	O	Thioredoxin	-	-	1.8.1.8	ko:K03672	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Thioredoxin
HKD3_k127_1386485_4	1532557.JL37_09245	7.154e-135	434.0	COG0715@1|root,COG0715@2|Bacteria,1NUUC@1224|Proteobacteria,2VJ53@28216|Betaproteobacteria,3T56E@506|Alcaligenaceae	28216|Betaproteobacteria	P	NMT1-like family	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
HKD3_k127_1386485_0	1532557.JL37_09240	8.105e-226	706.0	COG0141@1|root,COG0141@2|Bacteria,1MUUF@1224|Proteobacteria,2VMVH@28216|Betaproteobacteria,3T71P@506|Alcaligenaceae	28216|Betaproteobacteria	E	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine	hisD2	-	1.1.1.308	ko:K15509	-	-	-	-	ko00000,ko01000	-	-	-	Histidinol_dh
HKD3_k127_1386485_7	762376.AXYL_01400	1.672e-97	325.0	COG1028@1|root,COG1028@2|Bacteria,1MWB6@1224|Proteobacteria,2VQ3M@28216|Betaproteobacteria,3T6S5@506|Alcaligenaceae	28216|Betaproteobacteria	IQ	KR domain	-	-	1.1.1.69	ko:K00046	-	-	-	-	ko00000,ko01000	-	-	-	adh_short_C2
HKD3_k127_1386485_5	795666.MW7_1874	1.382e-124	410.0	COG1063@1|root,COG1063@2|Bacteria,1MWX0@1224|Proteobacteria,2VKWS@28216|Betaproteobacteria,1K3IT@119060|Burkholderiaceae	28216|Betaproteobacteria	E	Alcohol dehydrogenase GroES-like domain	-	-	1.1.1.1	ko:K00001	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
HKD3_k127_1386485_13	706587.Desti_3221	3.958e-18	96.0	COG0715@1|root,COG0715@2|Bacteria	2|Bacteria	P	thiamine-containing compound biosynthetic process	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
HKD3_k127_1386485_9	706587.Desti_5188	1.321e-68	258.0	COG1116@1|root,COG1116@2|Bacteria,1N7FP@1224|Proteobacteria	1224|Proteobacteria	P	ABC transporter	-	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
HKD3_k127_1386485_8	706587.Desti_5187	2.818e-75	277.0	COG0600@1|root,COG0600@2|Bacteria,1MWDJ@1224|Proteobacteria,42RKW@68525|delta/epsilon subdivisions,2X5I8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
HKD3_k127_1386485_6	1121861.KB899917_gene3601	9.543e-110	362.0	COG3246@1|root,COG3246@2|Bacteria,1MZTP@1224|Proteobacteria,2TQKN@28211|Alphaproteobacteria,2JQGU@204441|Rhodospirillales	204441|Rhodospirillales	S	beta-keto acid cleavage enzyme	-	-	-	-	-	-	-	-	-	-	-	-	BKACE
HKD3_k127_1386485_2	1458357.BG58_12395	1.122e-175	563.0	COG0439@1|root,COG0439@2|Bacteria,1MU4H@1224|Proteobacteria,2VZZH@28216|Betaproteobacteria,1KGQ1@119060|Burkholderiaceae	28216|Betaproteobacteria	I	Biotin carboxylase C-terminal domain	accC	-	6.3.4.14,6.4.1.2	ko:K01961	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04385	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
HKD3_k127_1386485_12	1458357.BG58_12390	1.648e-27	119.0	COG0511@1|root,COG0511@2|Bacteria,1PZH4@1224|Proteobacteria,2W49Q@28216|Betaproteobacteria	28216|Betaproteobacteria	I	first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA	-	-	-	ko:K02160	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742	RC00040,RC00367	ko00000,ko00001,ko00002	-	-	-	Biotin_lipoyl
HKD3_k127_1386485_1	450380.JPSY01000001_gene1768	3.449e-178	579.0	COG5016@1|root,COG5016@2|Bacteria,2I6EH@201174|Actinobacteria	201174|Actinobacteria	C	Conserved carboxylase domain	-	-	-	-	-	-	-	-	-	-	-	-	HMGL-like,PYC_OADA
HKD3_k127_1386485_10	795666.MW7_1790	1.91e-51	201.0	COG1786@1|root,COG1786@2|Bacteria,1RFUH@1224|Proteobacteria,2VSAS@28216|Betaproteobacteria,1KBB8@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Protein of unknown function DUF126	-	-	-	ko:K09128	-	-	-	-	ko00000	-	-	-	DUF126
HKD3_k127_1386485_3	795666.MW7_1789	1.552e-160	528.0	COG1679@1|root,COG1679@2|Bacteria,1NFH4@1224|Proteobacteria,2VISW@28216|Betaproteobacteria,1KHHY@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Protein of unknown function (DUF521)	-	-	-	ko:K09123	-	-	-	-	ko00000	-	-	-	DUF521
HKD3_k127_1386485_11	266117.Rxyl_1269	5.294e-29	131.0	COG0405@1|root,COG0405@2|Bacteria,2GJYW@201174|Actinobacteria,4CPY9@84995|Rubrobacteria	84995|Rubrobacteria	E	Gamma-glutamyltranspeptidase	-	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
HKD3_k127_1420876_1	1163617.SCD_n00674	1.271e-38	149.0	COG0848@1|root,COG0848@2|Bacteria,1RGWR@1224|Proteobacteria,2VT20@28216|Betaproteobacteria	28216|Betaproteobacteria	U	Pfam Biopolymer transport protein ExbD TolR	tolR	-	-	ko:K03560	-	-	-	-	ko00000,ko02000	1.A.30.2.2	-	-	ExbD
HKD3_k127_1420876_0	85643.Tmz1t_0785	1.258e-79	277.0	COG0811@1|root,COG0811@2|Bacteria,1NCWW@1224|Proteobacteria,2VJPW@28216|Betaproteobacteria,2KV8T@206389|Rhodocyclales	206389|Rhodocyclales	U	MotA TolQ ExbB proton channel	tolQ	-	-	ko:K03562	ko01120,map01120	-	-	-	ko00000,ko02000	1.A.30.2.2	-	-	MotA_ExbB
HKD3_k127_1420876_2	1123392.AQWL01000005_gene2946	8.66e-38	146.0	COG0824@1|root,COG0824@2|Bacteria,1MZH6@1224|Proteobacteria,2VUEV@28216|Betaproteobacteria,1KT2T@119069|Hydrogenophilales	119069|Hydrogenophilales	S	Thioesterase-like superfamily	-	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT
HKD3_k127_145075_0	1384054.N790_05315	1.331e-135	438.0	COG1216@1|root,COG1216@2|Bacteria,1QVEM@1224|Proteobacteria,1T49M@1236|Gammaproteobacteria,1X4E9@135614|Xanthomonadales	135614|Xanthomonadales	S	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HKD3_k127_145075_4	397945.Aave_4064	1.066e-14	87.0	COG2076@1|root,COG2076@2|Bacteria,1NHR2@1224|Proteobacteria,2VXSA@28216|Betaproteobacteria,4AFU5@80864|Comamonadaceae	28216|Betaproteobacteria	P	Permeases of the drug metabolite transporter (DMT) superfamily	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HKD3_k127_145075_2	357808.RoseRS_3868	3.532e-110	379.0	COG0399@1|root,COG0399@2|Bacteria,2G7J4@200795|Chloroflexi,375E3@32061|Chloroflexia	32061|Chloroflexia	E	aromatic amino acid beta-eliminating lyase threonine aldolase	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
HKD3_k127_145075_1	35754.JNYJ01000001_gene7217	1.479e-118	389.0	COG0463@1|root,COG0463@2|Bacteria,2I3C0@201174|Actinobacteria	201174|Actinobacteria	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HKD3_k127_145075_3	768671.ThimaDRAFT_1568	5.1e-25	108.0	COG0110@1|root,COG0110@2|Bacteria,1MZV9@1224|Proteobacteria,1RXAQ@1236|Gammaproteobacteria,1WXX9@135613|Chromatiales	135613|Chromatiales	S	Hexapeptide repeat of succinyl-transferase	-	-	2.3.1.201	ko:K13018	ko00520,map00520	-	R10100	RC00004,RC00166	ko00000,ko00001,ko01000,ko01005	-	-	-	Hexapep
HKD3_k127_1453916_5	568706.BN118_0414	8.199e-54	191.0	COG4091@1|root,COG4091@2|Bacteria,1MUZX@1224|Proteobacteria,2VI2Z@28216|Betaproteobacteria,3T3EX@506|Alcaligenaceae	28216|Betaproteobacteria	E	Homoserine dehydrogenase, NAD binding domain-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,NAD_binding_3,SAF
HKD3_k127_1453916_3	426114.THI_0177	4.931e-77	263.0	COG1280@1|root,COG1280@2|Bacteria,1MXAI@1224|Proteobacteria,2VRXW@28216|Betaproteobacteria,1KPH1@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	LysE type translocator	rhtB_2	-	-	ko:K05834	-	-	-	-	ko00000,ko02000	2.A.76.1.1	-	-	LysE
HKD3_k127_1453916_2	522306.CAP2UW1_1651	3.701e-81	274.0	COG1999@1|root,COG1999@2|Bacteria,1R0QG@1224|Proteobacteria	1224|Proteobacteria	S	Redoxin	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
HKD3_k127_1453916_0	522306.CAP2UW1_1652	8.841e-276	867.0	COG4232@1|root,COG4233@1|root,COG4232@2|Bacteria,COG4233@2|Bacteria,1MU8W@1224|Proteobacteria,2VI8I@28216|Betaproteobacteria,1KQEJ@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	CO	Disulphide bond corrector protein DsbC	-	-	1.8.1.8	ko:K04084,ko:K08344	-	-	-	-	ko00000,ko01000,ko02000,ko03110	5.A.1.1,5.A.1.5	-	-	DsbC,DsbD,Thioredoxin_7
HKD3_k127_1453916_4	1100720.ALKN01000033_gene741	2.386e-64	229.0	COG2119@1|root,COG2119@2|Bacteria,1RDDV@1224|Proteobacteria,2VQ6X@28216|Betaproteobacteria,4A9XN@80864|Comamonadaceae	28216|Betaproteobacteria	S	Uncharacterized protein family UPF0016	-	-	-	-	-	-	-	-	-	-	-	-	UPF0016
HKD3_k127_1453916_1	882378.RBRH_03180	6.764e-105	344.0	COG0495@1|root,COG0495@2|Bacteria,1MV47@1224|Proteobacteria,2VH2J@28216|Betaproteobacteria,1K2G2@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
HKD3_k127_1483261_5	159450.NH14_06830	1.242e-11	77.0	COG0329@1|root,COG0329@2|Bacteria,1MWV5@1224|Proteobacteria,2VIEI@28216|Betaproteobacteria,1K1WJ@119060|Burkholderiaceae	28216|Betaproteobacteria	EM	Belongs to the DapA family	-	-	4.2.1.43,4.3.3.7	ko:K01714,ko:K13876	ko00053,ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00053,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R02278,R10147	RC00429,RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
HKD3_k127_1483261_2	1502851.FG93_04310	2.447e-72	262.0	COG2358@1|root,COG2358@2|Bacteria,1Q1N8@1224|Proteobacteria,2V9C0@28211|Alphaproteobacteria,3K4DF@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	NMT1-like family	-	-	-	-	-	-	-	-	-	-	-	-	NMT1_3
HKD3_k127_1483261_3	1234364.AMSF01000048_gene2051	2.496e-49	184.0	COG1403@1|root,COG1403@2|Bacteria,1RGZQ@1224|Proteobacteria,1S5V4@1236|Gammaproteobacteria,1X6UP@135614|Xanthomonadales	135614|Xanthomonadales	V	HNH nucleases	-	-	-	-	-	-	-	-	-	-	-	-	HNH
HKD3_k127_1483261_4	1042326.AZNV01000015_gene1441	3.006e-28	119.0	2B1JR@1|root,31U15@2|Bacteria,1NZMM@1224|Proteobacteria,2UT9C@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_1483261_1	338969.Rfer_1965	1.803e-186	592.0	COG1454@1|root,COG1454@2|Bacteria,1MVPH@1224|Proteobacteria,2VI90@28216|Betaproteobacteria,4A9Y2@80864|Comamonadaceae	28216|Betaproteobacteria	C	alcohol dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Fe-ADH
HKD3_k127_1483261_0	338969.Rfer_1964	0.0	1087.0	COG5322@1|root,COG5322@2|Bacteria,1R60X@1224|Proteobacteria,2W0QF@28216|Betaproteobacteria	28216|Betaproteobacteria	S	oxidoreductase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_1574815_10	62928.azo3374	2.824e-21	104.0	COG0607@1|root,32YCZ@2|Bacteria,1N6NN@1224|Proteobacteria,2VVV9@28216|Betaproteobacteria,2KX5R@206389|Rhodocyclales	206389|Rhodocyclales	P	Protein of unknown function (DUF2892)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2892
HKD3_k127_1574815_0	1123354.AUDR01000015_gene354	0.0	1306.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VI3F@28216|Betaproteobacteria,1KSFJ@119069|Hydrogenophilales	119069|Hydrogenophilales	V	AcrB/AcrD/AcrF family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
HKD3_k127_1574815_2	640081.Dsui_3442	2.381e-225	703.0	COG0446@1|root,COG0446@2|Bacteria,1N5MC@1224|Proteobacteria,2VKI2@28216|Betaproteobacteria,2KX65@206389|Rhodocyclales	206389|Rhodocyclales	S	FAD-dependent pyridine nucleotide-disulfide oxidoreductase	-	-	1.8.5.4	ko:K17218	ko00920,map00920	-	R10152	RC03155	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
HKD3_k127_1574815_5	1163617.SCD_n02696	7.563e-82	285.0	COG0845@1|root,COG0845@2|Bacteria,1NQZ0@1224|Proteobacteria,2VJAC@28216|Betaproteobacteria	28216|Betaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_D23
HKD3_k127_1574815_11	1279038.KB907342_gene2602	7.46e-16	85.0	2EGD6@1|root,33A4Z@2|Bacteria,1N733@1224|Proteobacteria,2UG8Q@28211|Alphaproteobacteria,2JTXJ@204441|Rhodospirillales	204441|Rhodospirillales	S	Protein of unknown function (DUF2892)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2892
HKD3_k127_1574815_9	1191523.MROS_1778	2.981e-39	161.0	COG0607@1|root,COG2391@1|root,COG0607@2|Bacteria,COG2391@2|Bacteria	2|Bacteria	P	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS	ygaP	-	-	ko:K07112	-	-	-	-	ko00000	-	-	-	DUF2892,Rhodanese,Sulf_transp
HKD3_k127_1574815_7	945713.IALB_1660	2.529e-41	162.0	COG2391@1|root,COG2391@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K07112	-	-	-	-	ko00000	-	-	-	Sulf_transp
HKD3_k127_1574815_3	1283300.ATXB01000001_gene2143	3.955e-135	449.0	COG0457@1|root,COG0457@2|Bacteria,1N0A9@1224|Proteobacteria,1RZSZ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_2,TPR_7
HKD3_k127_1574815_6	1187851.A33M_4067	6.562e-79	276.0	COG2897@1|root,COG2897@2|Bacteria,1MW4B@1224|Proteobacteria,2U2DD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Rhodanese Homology Domain	-	-	2.8.1.1,2.8.1.2	ko:K01011	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko01000	-	-	-	Rhodanese
HKD3_k127_1574815_1	1191523.MROS_1774	5.291e-316	984.0	COG0243@1|root,COG0243@2|Bacteria	2|Bacteria	C	molybdopterin cofactor binding	-	-	1.8.5.5	ko:K08352	ko00920,ko01120,map00920,map01120	-	R10149	RC02823	ko00000,ko00001,ko01000,ko02000	5.A.3.5	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
HKD3_k127_1574815_4	945713.IALB_1662	1.605e-92	307.0	COG0437@1|root,COG0437@2|Bacteria	2|Bacteria	C	4 iron, 4 sulfur cluster binding	nrfC	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0008150,GO:0008152,GO:0016491,GO:0016661,GO:0016662,GO:0030288,GO:0030313,GO:0031975,GO:0042279,GO:0042597,GO:0044464,GO:0055114,GO:0098809	-	ko:K04014,ko:K08353,ko:K08358,ko:K16293	ko00920,ko01120,ko02020,map00920,map01120,map02020	-	R10149,R10150	RC02823,RC03109	ko00000,ko00001,ko02000	5.A.3.10,5.A.3.5	-	iUMNK88_1353.UMNK88_4933	Fer4,Fer4_11,Fer4_3,Fer4_4
HKD3_k127_1574815_8	452637.Oter_1464	1.783e-39	151.0	COG3301@1|root,COG3301@2|Bacteria	2|Bacteria	P	Polysulphide reductase, NrfD	-	-	-	-	-	-	-	-	-	-	-	-	NrfD,NrfD_2
HKD3_k127_1628375_3	1500893.JQNB01000001_gene1479	2.141e-15	86.0	COG1082@1|root,COG1082@2|Bacteria,1MUQ0@1224|Proteobacteria,1RRXZ@1236|Gammaproteobacteria,1X90C@135614|Xanthomonadales	135614|Xanthomonadales	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
HKD3_k127_1628375_1	1005048.CFU_1941	1.209e-273	879.0	COG3962@1|root,COG3962@2|Bacteria,1MW0P@1224|Proteobacteria,2VP1K@28216|Betaproteobacteria,473NQ@75682|Oxalobacteraceae	28216|Betaproteobacteria	E	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain	iolD	-	3.7.1.22	ko:K03336	ko00562,ko01100,ko01120,map00562,map01100,map01120	-	R08603	RC02331	ko00000,ko00001,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
HKD3_k127_1628375_0	1169143.KB911041_gene544	1.039e-295	925.0	COG0524@1|root,COG3892@1|root,COG0524@2|Bacteria,COG3892@2|Bacteria,1MV6I@1224|Proteobacteria,2VMV5@28216|Betaproteobacteria,1K1MF@119060|Burkholderiaceae	28216|Betaproteobacteria	G	PfkB domain protein	iolC	-	2.7.1.92	ko:K03338	ko00562,ko01100,ko01120,map00562,map01100,map01120	-	R05661	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	DUF2090,PfkB
HKD3_k127_1628375_2	626418.bglu_1g29280	1.179e-74	264.0	COG0697@1|root,COG0697@2|Bacteria,1MVKG@1224|Proteobacteria,2VM56@28216|Betaproteobacteria,1K4PV@119060|Burkholderiaceae	28216|Betaproteobacteria	EG	EamA-like transporter family	eamA	-	-	ko:K15268	-	-	-	-	ko00000,ko02000	2.A.7.3.2	-	-	EamA
HKD3_k127_1628375_4	123899.JPQP01000003_gene1286	3.393e-08	57.0	COG4666@1|root,COG4666@2|Bacteria,1MUNB@1224|Proteobacteria,2VHUG@28216|Betaproteobacteria,3T1N0@506|Alcaligenaceae	28216|Betaproteobacteria	S	Transporter	-	-	-	-	-	-	-	-	-	-	-	-	DUF3394,DctM
HKD3_k127_1686692_5	1403819.BATR01000162_gene5307	5.972e-72	249.0	COG4260@1|root,COG4260@2|Bacteria,46UVR@74201|Verrucomicrobia,2IV4M@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	SPFH domain-Band 7 family	-	-	-	-	-	-	-	-	-	-	-	-	Band_7_1,HTH_17
HKD3_k127_1686692_6	1123393.KB891316_gene1654	1.409e-62	240.0	COG1651@1|root,COG1651@2|Bacteria,1RD39@1224|Proteobacteria,2VIHV@28216|Betaproteobacteria,1KRYJ@119069|Hydrogenophilales	119069|Hydrogenophilales	O	Disulfide bond isomerase protein N-terminus	-	-	5.3.4.1	ko:K03981	-	-	-	-	ko00000,ko01000,ko02044,ko03110	3.A.7.11.1	-	-	DsbC_N,Thioredoxin_2
HKD3_k127_1686692_2	1121035.AUCH01000016_gene2160	4.77e-91	325.0	COG0654@1|root,COG0654@2|Bacteria,1MU6I@1224|Proteobacteria,2VIPS@28216|Betaproteobacteria,2KUAJ@206389|Rhodocyclales	206389|Rhodocyclales	C	Ubiquinone biosynthesis hydroxylase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_2,FAD_binding_3,SE
HKD3_k127_1686692_4	1123354.AUDR01000013_gene644	1.74e-80	277.0	COG5405@1|root,COG5405@2|Bacteria,1MVF2@1224|Proteobacteria,2VIFV@28216|Betaproteobacteria,1KRFN@119069|Hydrogenophilales	119069|Hydrogenophilales	O	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery	hslV	-	3.4.25.2	ko:K01419	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Proteasome
HKD3_k127_1686692_8	85643.Tmz1t_0787	3.142e-43	174.0	COG1366@1|root,COG1366@2|Bacteria,1R08G@1224|Proteobacteria,2VIGK@28216|Betaproteobacteria,2KVYW@206389|Rhodocyclales	206389|Rhodocyclales	T	Belongs to the anti-sigma-factor antagonist family	-	-	-	-	-	-	-	-	-	-	-	-	STAS_2
HKD3_k127_1686692_3	1123368.AUIS01000033_gene1381	2.852e-89	315.0	COG0605@1|root,COG0605@2|Bacteria,1MVW2@1224|Proteobacteria,1RP7X@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Destroys radicals which are normally produced within the cells and which are toxic to biological systems	sodB	-	1.15.1.1	ko:K04564	ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016	-	-	-	ko00000,ko00001,ko01000	-	-	-	Sod_Fe_C,Sod_Fe_N
HKD3_k127_1686692_7	859657.RPSI07_3332	2.69e-55	198.0	COG1734@1|root,COG1734@2|Bacteria,1RD08@1224|Proteobacteria,2VQR5@28216|Betaproteobacteria,1K758@119060|Burkholderiaceae	28216|Betaproteobacteria	T	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters	dksA	-	-	ko:K06204	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000,ko03009,ko03021	-	-	-	zf-dskA_traR
HKD3_k127_1686692_0	1123392.AQWL01000002_gene1851	2.615e-145	472.0	COG0418@1|root,COG0418@2|Bacteria,1MUYP@1224|Proteobacteria,2VH6F@28216|Betaproteobacteria,1KRA9@119069|Hydrogenophilales	119069|Hydrogenophilales	F	Amidohydrolase family	-	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
HKD3_k127_1686692_1	59538.XP_005979433.1	3.1e-133	431.0	COG1233@1|root,KOG4254@2759|Eukaryota,38CXC@33154|Opisthokonta,3BDJK@33208|Metazoa,3CVDZ@33213|Bilateria,4861H@7711|Chordata,494P3@7742|Vertebrata,3J26K@40674|Mammalia,4IZNT@91561|Cetartiodactyla	59538.XP_005979433.1|-	H	Pyridine nucleotide-disulfide oxidoreductase domain-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_1692703_17	391937.NA2_12408	8.596e-27	119.0	COG2091@1|root,COG2091@2|Bacteria,1MZHC@1224|Proteobacteria,2UFA4@28211|Alphaproteobacteria,43M77@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	H	4'-phosphopantetheinyl transferase superfamily	-	-	-	ko:K06133	ko00770,map00770	-	R01625	RC00002	ko00000,ko00001,ko01000	-	-	-	ACPS
HKD3_k127_1692703_4	396588.Tgr7_1406	1.908e-140	479.0	COG0645@1|root,COG2187@1|root,COG0645@2|Bacteria,COG2187@2|Bacteria,1MU9M@1224|Proteobacteria,1RPG3@1236|Gammaproteobacteria,1WW4S@135613|Chromatiales	135613|Chromatiales	S	AAA domain	-	-	-	ko:K07028	-	-	-	-	ko00000	-	-	-	AAA_33,APH
HKD3_k127_1692703_9	292.DM42_4899	2.516e-93	338.0	COG2187@1|root,COG2187@2|Bacteria,1R98V@1224|Proteobacteria,2VM22@28216|Betaproteobacteria,1K6U0@119060|Burkholderiaceae	28216|Betaproteobacteria	S	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_1692703_6	1385935.N836_07005	1.152e-122	403.0	COG0462@1|root,COG0462@2|Bacteria,1G00F@1117|Cyanobacteria,1H7DZ@1150|Oscillatoriales	1117|Cyanobacteria	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	-	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyl_synth,Pribosyltran_N
HKD3_k127_1692703_0	1123393.KB891326_gene83	1.901e-235	744.0	COG1387@1|root,COG1387@2|Bacteria,1MYXV@1224|Proteobacteria,2VJIQ@28216|Betaproteobacteria,1KSJ5@119069|Hydrogenophilales	119069|Hydrogenophilales	L	DNA polymerase X family	-	-	-	ko:K02347	-	-	-	-	ko00000,ko03400	-	-	-	DNA_pol_B_thumb,HHH_5,HHH_8
HKD3_k127_1692703_7	1500894.JQNN01000001_gene2573	7.869e-118	406.0	COG2989@1|root,COG2989@2|Bacteria,1MV14@1224|Proteobacteria,2VHVQ@28216|Betaproteobacteria	28216|Betaproteobacteria	S	ErfK YbiS YcfS YnhG family protein	ycbB	-	-	ko:K21470	-	-	-	-	ko00000,ko01002,ko01011	-	-	-	PG_binding_1,YkuD
HKD3_k127_1692703_11	381666.H16_A0538	2.074e-48	181.0	COG3108@1|root,COG3108@2|Bacteria,1MWW2@1224|Proteobacteria,2VRCS@28216|Betaproteobacteria,1KB5E@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Bacterial protein of unknown function (DUF882)	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M15_2
HKD3_k127_1692703_1	713586.KB900536_gene819	1.461e-226	709.0	COG1690@1|root,COG1690@2|Bacteria,1MUHA@1224|Proteobacteria,1RMXH@1236|Gammaproteobacteria,1WW29@135613|Chromatiales	135613|Chromatiales	S	PFAM Uncharacterised protein family UPF0027	rtcB	-	6.5.1.3	ko:K14415	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RtcB
HKD3_k127_1692703_13	1123393.KB891316_gene1686	3.024e-47	173.0	COG0617@1|root,COG1371@1|root,COG0617@2|Bacteria,COG1371@2|Bacteria,1MU2X@1224|Proteobacteria,2VIN5@28216|Betaproteobacteria,1KRHG@119069|Hydrogenophilales	119069|Hydrogenophilales	J	Probable RNA and SrmB- binding site of polymerase A	-	-	2.7.7.72	ko:K00974	ko03013,map03013	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko00001,ko01000,ko03016	-	-	-	Archease,HD,PolyA_pol,PolyA_pol_RNAbd
HKD3_k127_1692703_3	388051.AUFE01000017_gene5729	2.29e-171	550.0	COG1488@1|root,COG1488@2|Bacteria,1QD76@1224|Proteobacteria,2WE4J@28216|Betaproteobacteria,1K19E@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP	-	-	6.3.4.21	ko:K00763	ko00760,ko01100,map00760,map01100	-	R01724	RC00033	ko00000,ko00001,ko01000	-	-	-	NAPRTase
HKD3_k127_1692703_18	748247.AZKH_3407	1.033e-18	87.0	COG4876@1|root,COG4876@2|Bacteria,1NJCS@1224|Proteobacteria,2VYBB@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_1692703_12	640081.Dsui_0699	7.927e-48	198.0	2DZ3T@1|root,32V6K@2|Bacteria,1N1CD@1224|Proteobacteria,2W3TW@28216|Betaproteobacteria,2KZ3D@206389|Rhodocyclales	206389|Rhodocyclales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_1692703_8	640081.Dsui_0698	7.416e-100	333.0	28P5Y@1|root,2ZC0T@2|Bacteria,1RBDV@1224|Proteobacteria,2VZTY@28216|Betaproteobacteria,2KYJ2@206389|Rhodocyclales	206389|Rhodocyclales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_1692703_2	640081.Dsui_0697	1.544e-216	699.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,2VKJ8@28216|Betaproteobacteria,2KW95@206389|Rhodocyclales	206389|Rhodocyclales	KLT	Protein tyrosine kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HKD3_k127_1692703_10	522306.CAP2UW1_0602	5.297e-67	237.0	COG0221@1|root,COG0221@2|Bacteria,1RGCP@1224|Proteobacteria,2VRVG@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Inorganic pyrophosphatase	-	-	3.6.1.1	ko:K01507	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyrophosphatase
HKD3_k127_1692703_16	267608.RSp1653	6.309e-31	125.0	COG1622@1|root,COG1622@2|Bacteria,1NEC9@1224|Proteobacteria,2VWA0@28216|Betaproteobacteria,1KGBZ@119060|Burkholderiaceae	28216|Betaproteobacteria	C	cytochrome c oxidase subunit II	-	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	Cupredoxin_1
HKD3_k127_1692703_5	1120999.JONM01000002_gene542	7.915e-137	441.0	COG1409@1|root,COG1409@2|Bacteria,1MUQJ@1224|Proteobacteria,2VJNP@28216|Betaproteobacteria,2KT4R@206351|Neisseriales	206351|Neisseriales	S	Calcineurin-like phosphoesterase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
HKD3_k127_1692703_14	485913.Krac_10224	7.367e-40	154.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD3_k127_1692703_15	485913.Krac_10225	3.035e-37	156.0	COG5662@1|root,COG5662@2|Bacteria	2|Bacteria	K	AntiSigma factor	-	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
HKD3_k127_1692703_21	983917.RGE_16330	2.134e-06	56.0	COG4096@1|root,COG4096@2|Bacteria,1QXJA@1224|Proteobacteria,2WH5I@28216|Betaproteobacteria,1KNYQ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	V	Type III restriction enzyme, res subunit	-	-	3.1.21.5	ko:K01156	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	ResIII
HKD3_k127_1692703_20	1500893.JQNB01000001_gene145	8.862e-08	59.0	2DA9N@1|root,32TUZ@2|Bacteria,1QVBT@1224|Proteobacteria,1S8UR@1236|Gammaproteobacteria,1XD95@135614|Xanthomonadales	135614|Xanthomonadales	S	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HKD3_k127_1692703_19	1117958.PE143B_0109380	1.104e-14	84.0	COG2510@1|root,COG2510@2|Bacteria,1QXAZ@1224|Proteobacteria,1T36T@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HKD3_k127_1716716_5	522306.CAP2UW1_1893	3.542e-108	355.0	COG4670@1|root,COG4670@2|Bacteria,1MUJW@1224|Proteobacteria,2VH8B@28216|Betaproteobacteria,1KR3Z@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	I	Malonate decarboxylase, alpha subunit, transporter	-	-	2.8.3.1	ko:K01026	ko00620,ko00640,ko00643,ko01100,ko01120,map00620,map00640,map00643,map01100,map01120	-	R00928,R01449,R05508	RC00012,RC00014,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
HKD3_k127_1716716_9	765910.MARPU_06830	9.236e-66	238.0	COG1477@1|root,COG1477@2|Bacteria,1MW6K@1224|Proteobacteria,1RNMZ@1236|Gammaproteobacteria,1WWAK@135613|Chromatiales	135613|Chromatiales	H	Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein	-	-	2.7.1.180	ko:K03734	-	-	-	-	ko00000,ko01000	-	-	-	ApbE
HKD3_k127_1716716_12	187272.Mlg_1220	3.545e-21	99.0	COG2905@1|root,COG2905@2|Bacteria,1QTTR@1224|Proteobacteria,1T1K1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	CBS domain	hrp1	-	-	-	-	-	-	-	-	-	-	-	CBS
HKD3_k127_1716716_2	497321.C664_04122	5.148e-183	580.0	COG2871@1|root,COG2871@2|Bacteria,1QTUV@1224|Proteobacteria,2VNTV@28216|Betaproteobacteria,2KZZW@206389|Rhodocyclales	206389|Rhodocyclales	C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway	nqrF	-	1.6.5.8	ko:K00351	-	-	-	-	ko00000,ko01000	-	-	-	FAD_binding_6,Fer2,NAD_binding_1
HKD3_k127_1716716_7	751994.AGIG01000030_gene735	4.642e-82	278.0	COG2209@1|root,COG2209@2|Bacteria,1R33S@1224|Proteobacteria,1RMWV@1236|Gammaproteobacteria,1J5JH@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol	nqrE	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0008137,GO:0008150,GO:0008152,GO:0015672,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030001,GO:0030964,GO:0032991,GO:0044425,GO:0050136,GO:0051179,GO:0051234,GO:0055114,GO:0098796,GO:1902494	1.6.5.8	ko:K00350	-	-	-	-	ko00000,ko01000	-	-	-	Rnf-Nqr
HKD3_k127_1716716_8	225937.HP15_2250	2.965e-77	276.0	COG1347@1|root,COG1347@2|Bacteria,1MUZR@1224|Proteobacteria,1RNFE@1236|Gammaproteobacteria,46413@72275|Alteromonadaceae	1236|Gammaproteobacteria	C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol	nqrD	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015672,GO:0015980,GO:0016020,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0030001,GO:0030964,GO:0032991,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044464,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0051179,GO:0051234,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072521,GO:0098796,GO:1901135,GO:1901360,GO:1901564,GO:1902494	1.6.5.8	ko:K00349	-	-	-	-	ko00000,ko01000	-	-	-	Rnf-Nqr
HKD3_k127_1716716_10	1115512.EH105704_24_00220	4.115e-65	231.0	COG2869@1|root,COG2869@2|Bacteria,1MVDI@1224|Proteobacteria,1RR85@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol	nqrC	-	1.6.5.8	ko:K00348	-	-	-	-	ko00000,ko01000	-	-	-	FMN_bind
HKD3_k127_1716716_3	1001585.MDS_1648	1.18e-145	473.0	COG1805@1|root,COG1805@2|Bacteria,1QTUU@1224|Proteobacteria,1RMGH@1236|Gammaproteobacteria,1YEGK@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol	nqrB	GO:0000166,GO:0003674,GO:0003824,GO:0003954,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0008137,GO:0008144,GO:0008150,GO:0008152,GO:0010181,GO:0015672,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0019842,GO:0030001,GO:0030964,GO:0032553,GO:0032991,GO:0036094,GO:0043167,GO:0043168,GO:0044425,GO:0044464,GO:0048037,GO:0050136,GO:0050662,GO:0051179,GO:0051234,GO:0055114,GO:0071944,GO:0097159,GO:0097367,GO:0098796,GO:1901265,GO:1901363,GO:1902444,GO:1902494	1.6.5.8	ko:K00347	-	-	-	-	ko00000,ko01000	-	-	-	NQR2_RnfD_RnfE
HKD3_k127_1716716_4	391625.PPSIR1_12063	1.192e-138	453.0	COG1726@1|root,COG1726@2|Bacteria,1MU36@1224|Proteobacteria,42PMT@68525|delta/epsilon subdivisions,2WK84@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol	nqrA	-	1.6.5.8	ko:K00346	-	-	-	-	ko00000,ko01000	-	-	-	Fer4_10,NQRA,NQRA_SLBB
HKD3_k127_1716716_0	713587.THITH_03495	7.251e-261	814.0	COG0281@1|root,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,1RQ11@1236|Gammaproteobacteria,1WX9G@135613|Chromatiales	135613|Chromatiales	C	PFAM Malic enzyme, NAD binding domain	-	-	1.1.1.40	ko:K00029	ko00620,ko00710,ko01100,ko01120,ko01200,map00620,map00710,map01100,map01120,map01200	M00169,M00172	R00216	RC00105	ko00000,ko00001,ko00002,ko01000	-	-	-	Malic_M,malic
HKD3_k127_1716716_11	85643.Tmz1t_2947	3.532e-32	128.0	COG1145@1|root,COG1145@2|Bacteria,1MZ6H@1224|Proteobacteria	1224|Proteobacteria	C	Ferredoxin	fdxB	-	-	ko:K05337	-	-	-	-	ko00000	-	-	-	Fer4
HKD3_k127_1716716_6	595460.RRSWK_03756	1.294e-104	374.0	COG0167@1|root,COG0167@2|Bacteria	2|Bacteria	F	dihydroorotate dehydrogenase activity	-	-	1.3.98.1	ko:K00226	ko00240,ko01100,map00240,map01100	M00051	R01867	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
HKD3_k127_1716716_1	595460.RRSWK_03757	8.018e-237	747.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,2IYDT@203682|Planctomycetes	203682|Planctomycetes	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	-	-	-	-	-	-	-	-	-	-	-	-	EKR,Fer4_16,PFOR_II,POR,POR_N,TPP_enzyme_C
HKD3_k127_1818573_1	768066.HELO_1070	1.472e-51	187.0	COG1414@1|root,COG1414@2|Bacteria,1MUNW@1224|Proteobacteria,1RY9N@1236|Gammaproteobacteria,1XKZ2@135619|Oceanospirillales	135619|Oceanospirillales	K	IclR family transcriptional regulator	-	-	-	ko:K02624,ko:K13641,ko:K20539	ko02024,map02024	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_IclR,IclR
HKD3_k127_1818573_0	1510531.JQJJ01000008_gene3856	7.371e-63	221.0	COG3896@1|root,COG3896@2|Bacteria,1NX1Z@1224|Proteobacteria,2U3CG@28211|Alphaproteobacteria,3K41A@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	V	Chloramphenicol phosphotransferase-like protein	-	-	-	ko:K18554	-	-	-	-	br01600,ko00000,ko01000,ko01504	-	-	-	CPT
HKD3_k127_1818573_2	395965.Msil_3913	2.589e-23	111.0	COG3474@1|root,COG3474@2|Bacteria,1RIDN@1224|Proteobacteria,2U142@28211|Alphaproteobacteria,3NB5F@45404|Beijerinckiaceae	28211|Alphaproteobacteria	C	Cytochrome c	cyc	-	-	ko:K08738	ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	3.D.4.6	-	-	Cytochrom_C
HKD3_k127_1818573_3	1123487.KB892841_gene4323	6.473e-19	88.0	COG1472@1|root,COG1472@2|Bacteria,1MVAJ@1224|Proteobacteria,2VHAR@28216|Betaproteobacteria,2KV0Y@206389|Rhodocyclales	206389|Rhodocyclales	G	Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides	nagZ	-	3.2.1.52	ko:K01207	ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501	M00628	R00022,R05963,R07809,R07810,R10831	RC00049	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyco_hydro_3
HKD3_k127_1882453_0	757424.Hsero_4125	1.307e-186	586.0	COG3396@1|root,COG3396@2|Bacteria,1MVQ7@1224|Proteobacteria,2VHQZ@28216|Betaproteobacteria,473RH@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Phenylacetic acid catabolic protein	paaA	-	1.14.13.149	ko:K02609	ko00360,ko01120,map00360,map01120	-	R09838	RC02690	ko00000,ko00001,ko01000	-	-	-	PaaA_PaaC
HKD3_k127_1882453_3	379066.GAU_0262	6.502e-75	262.0	COG3327@1|root,COG3327@2|Bacteria	2|Bacteria	K	negative regulation of DNA-templated transcription, initiation	paaX	GO:0000976,GO:0000984,GO:0001017,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0006082,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006805,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009059,GO:0009404,GO:0009407,GO:0009410,GO:0009636,GO:0009850,GO:0009852,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010124,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0010817,GO:0016054,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019439,GO:0019748,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031333,GO:0032774,GO:0032787,GO:0034641,GO:0034645,GO:0034654,GO:0042178,GO:0042221,GO:0042445,GO:0042447,GO:0042537,GO:0043170,GO:0043254,GO:0043436,GO:0043565,GO:0044087,GO:0044212,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044271,GO:0044281,GO:0044282,GO:0045892,GO:0045934,GO:0046395,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051129,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051716,GO:0060255,GO:0065007,GO:0065008,GO:0070887,GO:0071466,GO:0071704,GO:0072329,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0098754,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901575,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2000142,GO:2000143,GO:2001141	-	ko:K02616	-	-	-	-	ko00000,ko03000	-	-	-	PaaX,PaaX_C
HKD3_k127_1882453_1	1144343.PMI41_03203	1.855e-110	377.0	COG1177@1|root,COG1177@2|Bacteria,1R5TG@1224|Proteobacteria,2TUP9@28211|Alphaproteobacteria,43JZG@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
HKD3_k127_1882453_2	1449065.JMLL01000012_gene3459	4.812e-104	344.0	COG1176@1|root,COG1176@2|Bacteria,1QCGB@1224|Proteobacteria,2TVIQ@28211|Alphaproteobacteria,43N9Y@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
HKD3_k127_1926591_3	395019.Bmul_6130	2.394e-26	123.0	COG0346@1|root,COG0346@2|Bacteria,1RD12@1224|Proteobacteria,2VRQ0@28216|Betaproteobacteria,1K6Z2@119060|Burkholderiaceae	28216|Betaproteobacteria	E	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase,Glyoxalase_4
HKD3_k127_1926591_1	365044.Pnap_1551	2.181e-113	391.0	COG1893@1|root,COG1893@2|Bacteria,1P0AW@1224|Proteobacteria,2VKA6@28216|Betaproteobacteria,4AGUN@80864|Comamonadaceae	28216|Betaproteobacteria	H	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid	-	-	1.1.1.169	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R02472	RC00726	ko00000,ko00001,ko00002,ko01000	-	-	-	ApbA,ApbA_C
HKD3_k127_1926591_0	1005395.CSV86_00696	2.139e-131	429.0	COG0673@1|root,COG0673@2|Bacteria,1MUP0@1224|Proteobacteria,1S1E3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	oxidoreductase	wblB	-	1.1.1.335	ko:K13020	ko00520,map00520	-	R10140	RC00182	ko00000,ko00001,ko01000,ko01005	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
HKD3_k127_1926591_2	926550.CLDAP_26180	3.157e-76	263.0	COG0673@1|root,COG0673@2|Bacteria,2G8BH@200795|Chloroflexi	200795|Chloroflexi	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
HKD3_k127_19520_0	1157708.KB907452_gene3975	1.912e-150	480.0	COG0329@1|root,COG0329@2|Bacteria,1MWV5@1224|Proteobacteria,2VIEI@28216|Betaproteobacteria,4AARS@80864|Comamonadaceae	28216|Betaproteobacteria	EM	Belongs to the DapA family	-	-	4.2.1.43,4.3.3.7	ko:K01714,ko:K13876	ko00053,ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00053,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R02278,R10147	RC00429,RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
HKD3_k127_19520_1	1242864.D187_004492	3.737e-87	301.0	COG4403@1|root,COG4403@2|Bacteria,1PR3F@1224|Proteobacteria,438MM@68525|delta/epsilon subdivisions,2X8SR@28221|Deltaproteobacteria,2YXA3@29|Myxococcales	28221|Deltaproteobacteria	V	Lanthionine synthetase C-like protein	-	-	-	-	-	-	-	-	-	-	-	-	LANC_like
HKD3_k127_1955007_0	582744.Msip34_0342	0.0	1526.0	COG1305@1|root,COG4196@1|root,COG1305@2|Bacteria,COG4196@2|Bacteria,1MVAG@1224|Proteobacteria,2VKKZ@28216|Betaproteobacteria,2KKJ6@206350|Nitrosomonadales	206350|Nitrosomonadales	E	Putative amidoligase enzyme (DUF2126)	-	-	-	-	-	-	-	-	-	-	-	-	Bact_transglu_N,DUF2126,Transglut_core
HKD3_k127_1955007_2	1458357.BG58_04610	9.939e-186	596.0	COG0008@1|root,COG0008@2|Bacteria,1MUCR@1224|Proteobacteria,2VH5S@28216|Betaproteobacteria,1K3GE@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
HKD3_k127_1955007_1	1163617.SCD_n01612	1.471e-231	722.0	COG0504@1|root,COG0504@2|Bacteria,1MUIT@1224|Proteobacteria,2VHVA@28216|Betaproteobacteria	28216|Betaproteobacteria	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	GO:0001775,GO:0002376,GO:0003674,GO:0003824,GO:0003883,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006213,GO:0006220,GO:0006221,GO:0006241,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008283,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009208,GO:0009209,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016874,GO:0016879,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032943,GO:0034404,GO:0034641,GO:0034654,GO:0042098,GO:0042100,GO:0042110,GO:0042113,GO:0042221,GO:0042455,GO:0042493,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045321,GO:0046036,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0046649,GO:0046651,GO:0050896,GO:0055086,GO:0070661,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_synth_N,GATase
HKD3_k127_1997871_1	1123392.AQWL01000004_gene2711	5.019e-89	310.0	COG2850@1|root,COG2850@2|Bacteria,1MW30@1224|Proteobacteria,2VH3D@28216|Betaproteobacteria,1KSMT@119069|Hydrogenophilales	119069|Hydrogenophilales	S	A domain family that is part of the cupin metalloenzyme superfamily.	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_4
HKD3_k127_1997871_2	546274.EIKCOROL_01213	2.599e-49	192.0	COG1047@1|root,COG1047@2|Bacteria,1RD35@1224|Proteobacteria,2VQA2@28216|Betaproteobacteria,2KQVZ@206351|Neisseriales	206351|Neisseriales	G	Psort location Cytoplasmic, score	slyD	-	5.2.1.8	ko:K03775	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	FKBP_C
HKD3_k127_1997871_0	62928.azo2052	8.358e-171	545.0	COG0249@1|root,COG0249@2|Bacteria,1MUGX@1224|Proteobacteria,2VI3Z@28216|Betaproteobacteria,2KV02@206389|Rhodocyclales	206389|Rhodocyclales	L	that it carries out the mismatch recognition step. This protein has a weak ATPase activity	mutS	-	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
HKD3_k127_2054371_1	246197.MXAN_7158	1.836e-46	181.0	COG0308@1|root,COG0308@2|Bacteria,1MUCI@1224|Proteobacteria	1224|Proteobacteria	E	aminopeptidase N	-	-	3.4.11.14	ko:K01263	-	-	-	-	ko00000,ko01000	-	-	-	ERAP1_C,Peptidase_M1
HKD3_k127_2054371_0	76114.ebA5836	9.801e-308	955.0	COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,1MVE0@1224|Proteobacteria,2VIW3@28216|Betaproteobacteria,2KVAF@206389|Rhodocyclales	206389|Rhodocyclales	C	NADH:flavin oxidoreductase / NADH oxidase family	-	-	1.3.1.34	ko:K00219	-	-	-	-	ko00000,ko01000	-	-	-	ECH_1,Oxidored_FMN,Pyr_redox_2
HKD3_k127_2152730_0	1288494.EBAPG3_13860	1.399e-202	638.0	COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,2VI7M@28216|Betaproteobacteria,372K8@32003|Nitrosomonadales	28216|Betaproteobacteria	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
HKD3_k127_2152730_2	1348657.M622_00415	3.629e-86	295.0	COG0491@1|root,COG0491@2|Bacteria,1NCIF@1224|Proteobacteria,2VJVR@28216|Betaproteobacteria,2KV3A@206389|Rhodocyclales	206389|Rhodocyclales	S	COG0491 Zn-dependent hydrolases, including glyoxylases	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HKD3_k127_2152730_6	391735.Veis_1277	1.181e-33	135.0	COG3909@1|root,COG3909@2|Bacteria,1N1E5@1224|Proteobacteria,2VSGD@28216|Betaproteobacteria,4AEJ2@80864|Comamonadaceae	28216|Betaproteobacteria	C	PFAM cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C_2
HKD3_k127_2152730_9	94624.Bpet2597	2.878e-09	71.0	2C5P4@1|root,3310H@2|Bacteria,1N6V1@1224|Proteobacteria,2VVVI@28216|Betaproteobacteria,3T4VP@506|Alcaligenaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
HKD3_k127_2152730_1	1121479.AUBS01000005_gene2711	4.992e-150	486.0	COG4553@1|root,COG4553@2|Bacteria,1MVUH@1224|Proteobacteria,2TXBF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Protein of unknown function (DUF3141)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3141,PHB_depo_C
HKD3_k127_2152730_5	196367.JNFG01000023_gene8133	4.424e-45	174.0	COG3658@1|root,COG3658@2|Bacteria,1RIG7@1224|Proteobacteria,2VQQ0@28216|Betaproteobacteria,1K6MN@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Cytochrome B561	-	-	-	-	-	-	-	-	-	-	-	-	Ni_hydr_CYTB
HKD3_k127_2152730_4	1000565.METUNv1_02143	1.605e-52	199.0	COG2095@1|root,COG2095@2|Bacteria,1MX5T@1224|Proteobacteria,2VIBH@28216|Betaproteobacteria,2KXPV@206389|Rhodocyclales	206389|Rhodocyclales	U	MarC family integral membrane protein	-	-	-	ko:K05595	-	-	-	-	ko00000,ko02000	2.A.95.1	-	-	MarC
HKD3_k127_2152730_3	381666.H16_A3099	6.625e-80	274.0	COG1346@1|root,COG1346@2|Bacteria,1MV81@1224|Proteobacteria,2VH4N@28216|Betaproteobacteria,1K2SA@119060|Burkholderiaceae	28216|Betaproteobacteria	M	PFAM LrgB family protein	lrgB	-	-	-	-	-	-	-	-	-	-	-	LrgB
HKD3_k127_2152730_7	62928.azo1155	3.955e-24	109.0	COG1380@1|root,COG1380@2|Bacteria,1N753@1224|Proteobacteria,2VTZY@28216|Betaproteobacteria,2KX00@206389|Rhodocyclales	206389|Rhodocyclales	S	effector of murein hydrolase LrgA	-	-	-	ko:K06518	-	-	-	-	ko00000,ko02000	1.E.14.2	-	-	LrgA
HKD3_k127_2315365_0	265072.Mfla_0750	1.57e-164	522.0	COG0484@1|root,COG0484@2|Bacteria,1MVMS@1224|Proteobacteria,2VHEH@28216|Betaproteobacteria,2KKPJ@206350|Nitrosomonadales	206350|Nitrosomonadales	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
HKD3_k127_2315365_1	640081.Dsui_1012	3.849e-150	490.0	COG0683@1|root,COG0683@2|Bacteria,1MXR4@1224|Proteobacteria,2VJXR@28216|Betaproteobacteria,2KUGR@206389|Rhodocyclales	206389|Rhodocyclales	E	Receptor family ligand binding region	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
HKD3_k127_2315365_3	667632.KB890218_gene318	8.807e-50	186.0	COG2068@1|root,COG2068@2|Bacteria,1MW0X@1224|Proteobacteria,2VSIN@28216|Betaproteobacteria,1JZRE@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Molybdopterin-guanine dinucleotide biosynthesis protein MobA	-	-	2.7.7.76	ko:K07141	ko00790,map00790	-	R11582	-	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
HKD3_k127_2315365_2	1265490.JHVY01000009_gene4256	2.613e-73	255.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS_3,PAS_9,Reg_prop,Y_Y_Y
HKD3_k127_241799_1	640081.Dsui_1007	1.389e-95	331.0	COG0477@1|root,COG2814@2|Bacteria,1MVHG@1224|Proteobacteria,2VHCU@28216|Betaproteobacteria,2KUJS@206389|Rhodocyclales	206389|Rhodocyclales	EGP	Major Facilitator	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD3_k127_241799_0	713586.KB900536_gene1208	7.304e-209	687.0	COG4191@1|root,COG5000@1|root,COG4191@2|Bacteria,COG5000@2|Bacteria,1RCM9@1224|Proteobacteria,1RP53@1236|Gammaproteobacteria,1WZX9@135613|Chromatiales	135613|Chromatiales	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg
HKD3_k127_2441161_0	795666.MW7_0420	2.721e-76	257.0	COG0148@1|root,COG0148@2|Bacteria,1MU1N@1224|Proteobacteria,2VH7Y@28216|Betaproteobacteria,1K1WM@119060|Burkholderiaceae	28216|Betaproteobacteria	F	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	GO:0000015,GO:0000287,GO:0003674,GO:0003824,GO:0004634,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005856,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009986,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016829,GO:0016835,GO:0016836,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0032991,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042802,GO:0042866,GO:0043167,GO:0043169,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046872,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1902494	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
HKD3_k127_2441161_2	1163617.SCD_n01609	7.966e-33	130.0	COG2919@1|root,COG2919@2|Bacteria,1N7AA@1224|Proteobacteria,2VVQJ@28216|Betaproteobacteria	28216|Betaproteobacteria	D	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic	ftsB	-	-	ko:K05589	-	-	-	-	ko00000,ko03036	-	-	-	DivIC
HKD3_k127_2441161_1	1163617.SCD_n01614	3.121e-57	209.0	COG0566@1|root,COG0566@2|Bacteria,1MWBE@1224|Proteobacteria,2WGF7@28216|Betaproteobacteria	28216|Betaproteobacteria	J	methyltransferase	-	-	-	ko:K03437	-	-	-	-	ko00000,ko03016	-	-	-	SpoU_methylase
HKD3_k127_24426_5	62928.azo2274	7.144e-70	241.0	COG1613@1|root,COG1613@2|Bacteria,1MUAU@1224|Proteobacteria,2VIQZ@28216|Betaproteobacteria,2KV40@206389|Rhodocyclales	206389|Rhodocyclales	P	COG1613 ABC-type sulfate transport system, periplasmic component	-	-	-	ko:K02048	ko00920,ko02010,map00920,map02010	M00185	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.1,3.A.1.6.3	-	-	SBP_bac_11
HKD3_k127_24426_3	765912.Thimo_0377	1.13e-141	467.0	COG2203@1|root,COG2204@1|root,COG2203@2|Bacteria,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1T1IW@1236|Gammaproteobacteria,1X2UX@135613|Chromatiales	135613|Chromatiales	T	Sigma-54 interaction domain	-	-	-	-	-	-	-	-	-	-	-	-	Sigma54_activat
HKD3_k127_24426_4	1265502.KB905969_gene1232	2.67e-126	421.0	COG1593@1|root,COG1593@2|Bacteria,1MUQE@1224|Proteobacteria,2VHK0@28216|Betaproteobacteria,4A9P3@80864|Comamonadaceae	28216|Betaproteobacteria	G	PFAM Malonyl-CoA decarboxylase	matA	-	4.1.1.9	ko:K01578	ko00410,ko00640,ko01100,ko04146,ko04152,map00410,map00640,map01100,map04146,map04152	-	R00233	RC00040	ko00000,ko00001,ko01000	-	-	-	MCD,MCD_N
HKD3_k127_24426_6	84531.JMTZ01000014_gene2727	8.5e-46	188.0	COG1309@1|root,COG1309@2|Bacteria,1RARJ@1224|Proteobacteria,1RYD5@1236|Gammaproteobacteria,1X7IN@135614|Xanthomonadales	135614|Xanthomonadales	K	BetI-type transcriptional repressor, C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_6,TetR_N
HKD3_k127_24426_1	84531.JMTZ01000014_gene2726	8.496e-152	496.0	COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,1RMDA@1236|Gammaproteobacteria,1X3EU@135614|Xanthomonadales	135614|Xanthomonadales	M	Outer membrane efflux protein	oprM	-	-	ko:K18139	ko01501,ko02024,map01501,map02024	M00642,M00643,M00647,M00718,M00768,M00822	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	1.B.17,2.A.6.2	-	-	OEP
HKD3_k127_24426_0	204773.HEAR2382	0.0	1503.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHFI@28216|Betaproteobacteria,472ZI@75682|Oxalobacteraceae	28216|Betaproteobacteria	U	Efflux pump	acrB	-	-	ko:K03296,ko:K18138,ko:K18322	ko01501,ko01503,ko02020,map01501,map01503,map02020	M00645,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2,2.A.6.2.41	-	-	ACR_tran
HKD3_k127_24426_2	204773.HEAR2381	1.581e-144	469.0	COG0845@1|root,COG0845@2|Bacteria,1MU78@1224|Proteobacteria,2VINC@28216|Betaproteobacteria,47353@75682|Oxalobacteraceae	28216|Betaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	acrA	-	-	ko:K03585,ko:K18321	ko01501,ko01503,ko02020,map01501,map01503,map02020	M00645,M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,2.A.6.2.41,8.A.1,8.A.1.6	-	-	Biotin_lipoyl_2,HlyD_D23
HKD3_k127_2454918_9	713586.KB900536_gene706	1.044e-14	83.0	COG1951@1|root,COG1951@2|Bacteria,1MW8J@1224|Proteobacteria,1RPUD@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Tartrate	-	-	4.2.1.2	ko:K01677	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumerase
HKD3_k127_2454918_7	713586.KB900536_gene708	8.719e-30	127.0	COG2009@1|root,COG2009@2|Bacteria,1N8VA@1224|Proteobacteria	1224|Proteobacteria	C	succinate dehydrogenase	-	-	-	ko:K00247	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020	M00009,M00011,M00150,M00173	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	Sdh_cyt
HKD3_k127_2454918_8	1121861.KB899918_gene3220	1.569e-24	116.0	COG2142@1|root,COG2142@2|Bacteria,1MZKE@1224|Proteobacteria,2UDDU@28211|Alphaproteobacteria,2JY8A@204441|Rhodospirillales	204441|Rhodospirillales	C	Succinate dehydrogenase/Fumarate reductase transmembrane subunit	-	-	-	-	-	-	-	-	-	-	-	-	Sdh_cyt
HKD3_k127_2454918_5	713586.KB900536_gene710	1.196e-109	361.0	COG0479@1|root,COG0479@2|Bacteria,1MVHS@1224|Proteobacteria,1RNWR@1236|Gammaproteobacteria,1WWKQ@135613|Chromatiales	1236|Gammaproteobacteria	C	TIGRFAM succinate dehydrogenase and fumarate reductase iron-sulfur protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer2_3,Fer4_17,Fer4_8
HKD3_k127_2454918_4	1126627.BAWE01000002_gene856	6.462e-112	372.0	COG2984@1|root,COG2984@2|Bacteria,1R7C2@1224|Proteobacteria,2TZKG@28211|Alphaproteobacteria,3JXR0@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	-	-	-	-	-	-	-	-	-	ABC_sub_bind
HKD3_k127_2454918_0	1532557.JL37_06530	3.143e-278	867.0	COG0028@1|root,COG0028@2|Bacteria,1MWUB@1224|Proteobacteria,2VMC1@28216|Betaproteobacteria,3T5NB@506|Alcaligenaceae	28216|Betaproteobacteria	EH	Belongs to the TPP enzyme family	xsc	-	2.3.3.15	ko:K03852	ko00430,map00430	-	R05651	RC02903,RC02909	ko00000,ko00001,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
HKD3_k127_2454918_1	504832.OCAR_6748	1.019e-243	762.0	COG2303@1|root,COG2303@2|Bacteria,1MV19@1224|Proteobacteria,2TQKQ@28211|Alphaproteobacteria,3JSS3@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	GMC oxidoreductase	-	-	1.1.99.1	ko:K00108	ko00260,ko01100,map00260,map01100	M00555	R01025	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	GMC_oxred_C,GMC_oxred_N
HKD3_k127_2454918_2	1411123.JQNH01000001_gene3811	1.018e-191	604.0	COG0686@1|root,COG0686@2|Bacteria,1QTX1@1224|Proteobacteria,2TQQC@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Belongs to the AlaDH PNT family	ald	-	1.4.1.1	ko:K00259	ko00250,ko00430,ko01100,map00250,map00430,map01100	-	R00396	RC00008	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
HKD3_k127_2454918_6	1122603.ATVI01000005_gene2950	3.145e-31	141.0	COG3832@1|root,COG3832@2|Bacteria,1N2PR@1224|Proteobacteria,1S71Z@1236|Gammaproteobacteria,1X850@135614|Xanthomonadales	135614|Xanthomonadales	S	Polyketide cyclase / dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
HKD3_k127_2454918_3	1411123.JQNH01000001_gene3810	6.567e-140	454.0	COG1167@1|root,COG1167@2|Bacteria,1MVGT@1224|Proteobacteria,2TRK7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs	-	-	-	ko:K00375	-	-	-	-	ko00000,ko03000	-	-	-	Aminotran_1_2,GntR
HKD3_k127_2462867_5	640081.Dsui_0656	2.738e-259	834.0	COG0643@1|root,COG0784@1|root,COG2198@1|root,COG0643@2|Bacteria,COG0784@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,2VJSZ@28216|Betaproteobacteria,2KUBP@206389|Rhodocyclales	206389|Rhodocyclales	KNT	COG0643 Chemotaxis protein histidine kinase and related kinases	pilL	-	-	ko:K02487,ko:K06596	ko02020,ko02025,map02020,map02025	M00507	-	-	ko00000,ko00001,ko00002,ko01001,ko02022,ko02035	-	-	-	CheW,HATPase_c,Hpt,Response_reg
HKD3_k127_2462867_3	1123020.AUIE01000044_gene1844	3.943e-299	932.0	COG0480@1|root,COG0480@2|Bacteria,1MVVY@1224|Proteobacteria,1RYCE@1236|Gammaproteobacteria,1YFG7@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	J	Elongation factor G, domain IV	-	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
HKD3_k127_2462867_21	1121448.DGI_0174	3.238e-61	221.0	COG1305@1|root,COG1305@2|Bacteria,1MVAG@1224|Proteobacteria,42P26@68525|delta/epsilon subdivisions,2WPT6@28221|Deltaproteobacteria,2M8JQ@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	Transglutaminase/protease-like homologues	-	-	-	-	-	-	-	-	-	-	-	-	Bact_transglu_N,Transglut_core
HKD3_k127_2462867_7	85643.Tmz1t_3694	4.6e-187	596.0	COG0415@1|root,COG0415@2|Bacteria,1MV9Y@1224|Proteobacteria,2VITS@28216|Betaproteobacteria,2KUA4@206389|Rhodocyclales	206389|Rhodocyclales	L	Belongs to the DNA photolyase family	phrB	-	4.1.99.3	ko:K01669	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_photolyase,FAD_binding_7
HKD3_k127_2462867_13	518766.Rmar_1400	1.797e-102	350.0	COG3540@1|root,COG3540@2|Bacteria,4NDUS@976|Bacteroidetes,1FJNA@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	P	COG3540 Phosphodiesterase alkaline phosphatase D	-	-	3.1.3.1	ko:K01113	ko00790,ko01100,ko02020,map00790,map01100,map02020	M00126	R04620	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PhoD
HKD3_k127_2462867_18	640081.Dsui_0593	2.038e-77	269.0	COG1678@1|root,COG1678@2|Bacteria,1RCXM@1224|Proteobacteria,2VJQA@28216|Betaproteobacteria,2KVN5@206389|Rhodocyclales	206389|Rhodocyclales	K	Belongs to the UPF0301 (AlgH) family	algH	-	-	ko:K07735	-	-	-	-	ko00000,ko03000	-	-	-	DUF179
HKD3_k127_2462867_24	748280.NH8B_0467	2.563e-40	154.0	COG0816@1|root,COG0816@2|Bacteria,1RDHZ@1224|Proteobacteria,2VUH0@28216|Betaproteobacteria,2KR8J@206351|Neisseriales	206351|Neisseriales	L	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA	yqgF	-	-	ko:K07447	-	-	-	-	ko00000,ko01000	-	-	-	RuvX
HKD3_k127_2462867_22	1095769.CAHF01000014_gene2846	8.478e-51	185.0	COG2065@1|root,COG2065@2|Bacteria,1RI6U@1224|Proteobacteria,2VSNM@28216|Betaproteobacteria,4740S@75682|Oxalobacteraceae	28216|Betaproteobacteria	F	Pyrimidine operon attenuation protein uracil phosphoribosyltransferase	pyrR	-	2.4.2.9	ko:K02825	ko00240,ko01100,map00240,map01100	-	R00966	RC00063	ko00000,ko00001,ko01000,ko03000	-	-	-	Pribosyltran
HKD3_k127_2462867_10	748247.AZKH_3843	7.175e-163	516.0	COG0540@1|root,COG0540@2|Bacteria,1MWAB@1224|Proteobacteria,2VHG9@28216|Betaproteobacteria,2KUTM@206389|Rhodocyclales	206389|Rhodocyclales	F	Belongs to the ATCase OTCase family	pyrB	-	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
HKD3_k127_2462867_8	1163617.SCD_n00209	4.205e-182	578.0	COG0044@1|root,COG0044@2|Bacteria,1MVXY@1224|Proteobacteria,2VH1E@28216|Betaproteobacteria	28216|Betaproteobacteria	F	dihydroorotase	pyrX	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1,Amidohydro_3
HKD3_k127_2462867_12	441620.Mpop_1756	4.687e-103	345.0	COG0412@1|root,COG0412@2|Bacteria,1MW7S@1224|Proteobacteria,2TTPH@28211|Alphaproteobacteria,1JRED@119045|Methylobacteriaceae	28211|Alphaproteobacteria	Q	PFAM Dienelactone hydrolase	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
HKD3_k127_2462867_15	243159.AFE_1832	1.135e-95	319.0	COG3751@1|root,COG3751@2|Bacteria,1RAJ8@1224|Proteobacteria,1S3II@1236|Gammaproteobacteria,2NDK3@225057|Acidithiobacillales	225057|Acidithiobacillales	O	2OG-Fe(II) oxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_2462867_27	639283.Snov_0417	1.66e-29	122.0	COG0071@1|root,COG0071@2|Bacteria,1N0RH@1224|Proteobacteria,2UE1E@28211|Alphaproteobacteria,3F1FV@335928|Xanthobacteraceae	28211|Alphaproteobacteria	O	Hsp20/alpha crystallin family	MA20_45160	-	-	-	-	-	-	-	-	-	-	-	HSP20
HKD3_k127_2462867_2	288000.BBta_7794	0.0	1061.0	COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,2U0IK@28211|Alphaproteobacteria,3JTMI@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	-	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
HKD3_k127_2462867_20	267608.RSp0024	1.696e-72	251.0	COG1881@1|root,COG1881@2|Bacteria,1N0Y4@1224|Proteobacteria,2VR39@28216|Betaproteobacteria,1K5JG@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Phosphatidylethanolamine-binding protein	-	-	-	ko:K06910	-	-	-	-	ko00000	-	-	-	PBP
HKD3_k127_2462867_17	388051.AUFE01000006_gene1255	1.718e-93	315.0	COG2128@1|root,COG2128@2|Bacteria,1MUDM@1224|Proteobacteria,2VIMU@28216|Betaproteobacteria,1JZUC@119060|Burkholderiaceae	28216|Betaproteobacteria	O	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity	-	-	4.1.1.44	ko:K01607	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	-	R03470	RC00938	ko00000,ko00001,ko01000	-	-	-	CMD
HKD3_k127_2462867_23	1175306.GWL_28720	6.691e-44	165.0	COG2924@1|root,COG2924@2|Bacteria,1MZ2V@1224|Proteobacteria,2VTYU@28216|Betaproteobacteria,474MR@75682|Oxalobacteraceae	28216|Betaproteobacteria	CO	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes	yggX	-	-	-	-	-	-	-	-	-	-	-	Iron_traffic
HKD3_k127_2462867_9	1163617.SCD_n02840	1.245e-166	537.0	COG0548@1|root,COG1246@1|root,COG0548@2|Bacteria,COG1246@2|Bacteria,1MUUP@1224|Proteobacteria,2VGZC@28216|Betaproteobacteria	28216|Betaproteobacteria	E	Belongs to the acetyltransferase family. ArgA subfamily	argA	-	2.3.1.1	ko:K14682	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,Acetyltransf_1
HKD3_k127_2462867_4	1163617.SCD_n00049	4.78e-294	923.0	COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,2VH4I@28216|Betaproteobacteria	28216|Betaproteobacteria	L	Helicase	uvrD	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
HKD3_k127_2462867_29	522306.CAP2UW1_1113	6.9e-25	121.0	COG5473@1|root,COG5473@2|Bacteria,1N9UJ@1224|Proteobacteria,2VNM5@28216|Betaproteobacteria,1KQZ5@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_2462867_14	1485544.JQKP01000002_gene1448	2.124e-102	342.0	COG2334@1|root,COG2334@2|Bacteria,1MUKJ@1224|Proteobacteria,2VH2I@28216|Betaproteobacteria,44V2D@713636|Nitrosomonadales	28216|Betaproteobacteria	H	Belongs to the pseudomonas-type ThrB family	thrB	-	2.7.1.39	ko:K02204	ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230	M00018	R01771	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	APH
HKD3_k127_2462867_30	76114.ebB140	4.017e-17	85.0	2C1YJ@1|root,32ZXK@2|Bacteria,1N98H@1224|Proteobacteria,2VVT5@28216|Betaproteobacteria,2KXDS@206389|Rhodocyclales	206389|Rhodocyclales	S	Protein of unknown function (DUF2782)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2782
HKD3_k127_2462867_16	1123354.AUDR01000001_gene2015	3.827e-95	317.0	COG1611@1|root,COG1611@2|Bacteria,1MU6N@1224|Proteobacteria,2VK4I@28216|Betaproteobacteria,1KRBF@119069|Hydrogenophilales	119069|Hydrogenophilales	S	Possible lysine decarboxylase	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
HKD3_k127_2462867_1	1123367.C666_04180	0.0	1157.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,2VJ57@28216|Betaproteobacteria,2KUC6@206389|Rhodocyclales	206389|Rhodocyclales	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
HKD3_k127_2462867_25	631362.Thi970DRAFT_02282	7.236e-40	159.0	COG5473@1|root,COG5473@2|Bacteria,1N9UJ@1224|Proteobacteria,1SZTB@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_2462867_11	314278.NB231_04715	6.098e-110	364.0	COG1741@1|root,COG1741@2|Bacteria,1MWIP@1224|Proteobacteria,1RNVM@1236|Gammaproteobacteria,1WXMH@135613|Chromatiales	135613|Chromatiales	S	Belongs to the pirin family	-	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin,Pirin_C
HKD3_k127_2462867_19	1163407.UU7_09455	5.054e-77	269.0	COG0586@1|root,COG0607@1|root,COG0586@2|Bacteria,COG0607@2|Bacteria,1R6F1@1224|Proteobacteria,1S4IC@1236|Gammaproteobacteria,1X62F@135614|Xanthomonadales	135614|Xanthomonadales	P	Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese,SNARE_assoc
HKD3_k127_2462867_28	29581.BW37_02719	5.088e-27	119.0	COG5528@1|root,COG5528@2|Bacteria,1RDUE@1224|Proteobacteria,2VRK8@28216|Betaproteobacteria,474GK@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Predicted integral membrane protein (DUF2269)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2269
HKD3_k127_2462867_0	314230.DSM3645_19063	0.0	1253.0	COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,2IYAH@203682|Planctomycetes	203682|Planctomycetes	C	FAD linked oxidases, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG,FAD-oxidase_C,FAD_binding_4,Fer4_17,Fer4_8
HKD3_k127_2462867_26	265072.Mfla_0365	1.811e-38	145.0	COG0234@1|root,COG0234@2|Bacteria,1MZ2X@1224|Proteobacteria,2VSKJ@28216|Betaproteobacteria,2KN35@206350|Nitrosomonadales	206350|Nitrosomonadales	O	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter	groS	-	-	ko:K04078	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Cpn10
HKD3_k127_2462867_6	1288494.EBAPG3_26720	4.642e-190	598.0	COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,2VIW1@28216|Betaproteobacteria,372Q8@32003|Nitrosomonadales	28216|Betaproteobacteria	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	-	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
HKD3_k127_2500259_0	381666.H16_A0280	0.0	1235.0	COG1703@1|root,COG1884@1|root,COG2185@1|root,COG1703@2|Bacteria,COG1884@2|Bacteria,COG2185@2|Bacteria,1MUXX@1224|Proteobacteria,2VH05@28216|Betaproteobacteria,1K4Q5@119060|Burkholderiaceae	28216|Betaproteobacteria	EI	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly	icmF	GO:0000166,GO:0000287,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0006139,GO:0006163,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009117,GO:0009150,GO:0009259,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016866,GO:0017076,GO:0017111,GO:0019001,GO:0019637,GO:0019693,GO:0019842,GO:0031419,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0034784,GO:0035383,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043603,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0046872,GO:0046906,GO:0047727,GO:0048037,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:0097159,GO:0097367,GO:1901135,GO:1901265,GO:1901360,GO:1901363,GO:1901564	5.4.99.13	ko:K11942	-	-	-	-	ko00000,ko01000	-	-	-	ArgK,B12-binding,MM_CoA_mutase
HKD3_k127_2502701_9	85643.Tmz1t_1500	2.552e-54	199.0	COG1385@1|root,COG1385@2|Bacteria,1MXCU@1224|Proteobacteria,2VJS2@28216|Betaproteobacteria,2KW6H@206389|Rhodocyclales	206389|Rhodocyclales	J	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit	-	-	2.1.1.193	ko:K09761	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_RNA
HKD3_k127_2502701_8	76114.ebA1095	6.635e-72	257.0	COG1225@1|root,COG1225@2|Bacteria,1R9YF@1224|Proteobacteria,2VN9B@28216|Betaproteobacteria,2KW4T@206389|Rhodocyclales	206389|Rhodocyclales	O	Redoxin	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
HKD3_k127_2502701_7	76114.ebA4859	2.644e-75	263.0	COG5473@1|root,COG5473@2|Bacteria,1MVRU@1224|Proteobacteria,2VK3K@28216|Betaproteobacteria,2KUXE@206389|Rhodocyclales	206389|Rhodocyclales	S	Predicted integral membrane protein (DUF2189)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2189
HKD3_k127_2502701_5	640081.Dsui_3019	2.137e-85	295.0	COG2267@1|root,COG2267@2|Bacteria,1Q6AF@1224|Proteobacteria,2VJQ3@28216|Betaproteobacteria,2KWPA@206389|Rhodocyclales	206389|Rhodocyclales	I	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_4
HKD3_k127_2502701_0	1265502.KB905936_gene2642	8.782e-216	677.0	COG2873@1|root,COG2873@2|Bacteria,1NQME@1224|Proteobacteria,2VHYA@28216|Betaproteobacteria,4AB52@80864|Comamonadaceae	28216|Betaproteobacteria	E	TIGRFAM O-acetylhomoserine O-acetylserine sulfhydrylase	metY	-	2.5.1.49	ko:K01740	ko00270,ko01100,map00270,map01100	-	R01287,R04859	RC00020,RC02821,RC02848	ko00000,ko00001,ko01000	-	-	-	Cys_Met_Meta_PP
HKD3_k127_2502701_11	1336208.JADY01000009_gene2620	1.407e-48	177.0	COG1764@1|root,COG1764@2|Bacteria,1RH9U@1224|Proteobacteria,2U768@28211|Alphaproteobacteria,2JSVD@204441|Rhodospirillales	204441|Rhodospirillales	O	OsmC-like protein	osmC	-	-	ko:K04063	-	-	-	-	ko00000	-	-	-	OsmC
HKD3_k127_2502701_1	1123368.AUIS01000031_gene1422	7.858e-137	453.0	COG1533@1|root,COG1533@2|Bacteria,1MW0H@1224|Proteobacteria,1RQNF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
HKD3_k127_2502701_4	1454004.AW11_03678	2.448e-95	317.0	COG0491@1|root,COG0491@2|Bacteria,1MUDN@1224|Proteobacteria,2VHMC@28216|Betaproteobacteria,1KQ6U@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	S	Metallo-beta-lactamase superfamily	ycbL	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HKD3_k127_2502701_6	1411123.JQNH01000001_gene1084	1.132e-80	274.0	COG0625@1|root,COG0625@2|Bacteria,1RA4M@1224|Proteobacteria,2TV0I@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Glutathione S-transferase	-	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C,GST_C_2,GST_N,GST_N_3
HKD3_k127_2502701_3	323097.Nham_3981	1.442e-102	351.0	COG1295@1|root,COG1295@2|Bacteria,1NH82@1224|Proteobacteria	1224|Proteobacteria	S	ribonuclease BN	-	-	-	-	-	-	-	-	-	-	-	-	Virul_fac_BrkB
HKD3_k127_2502701_12	477228.YO5_02982	1.809e-14	76.0	2CA5H@1|root,33A7N@2|Bacteria,1NI9X@1224|Proteobacteria,1T9T1@1236|Gammaproteobacteria,1Z3IT@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	S	Cysteine-rich CWC	-	-	-	-	-	-	-	-	-	-	-	-	Cys_rich_CWC
HKD3_k127_2502701_10	404589.Anae109_2915	9.142e-53	197.0	COG2010@1|root,COG2010@2|Bacteria,1RBTK@1224|Proteobacteria,43AHK@68525|delta/epsilon subdivisions,2X5XT@28221|Deltaproteobacteria,2YVZ8@29|Myxococcales	28221|Deltaproteobacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_2502701_2	338969.Rfer_0647	5.153e-132	432.0	COG2133@1|root,COG2133@2|Bacteria,1QZ0Q@1224|Proteobacteria,2WHH9@28216|Betaproteobacteria	28216|Betaproteobacteria	G	PEP-CTERM motif	-	-	-	-	-	-	-	-	-	-	-	-	VPEP
HKD3_k127_2502701_13	1229172.JQFA01000005_gene252	6.085e-07	55.0	COG1357@1|root,COG1357@2|Bacteria,1GCFK@1117|Cyanobacteria,1HE52@1150|Oscillatoriales	1117|Cyanobacteria	S	Pentapeptide repeats (9 copies)	-	-	-	-	-	-	-	-	-	-	-	-	Pentapeptide
HKD3_k127_2522251_4	381666.H16_A2197	4.211e-22	113.0	COG0650@1|root,COG0650@2|Bacteria,1MXV5@1224|Proteobacteria,2VKBD@28216|Betaproteobacteria,1K556@119060|Burkholderiaceae	28216|Betaproteobacteria	C	NADH dehydrogenase	hyfD	-	-	-	-	-	-	-	-	-	-	-	NADHdh
HKD3_k127_2522251_1	748247.AZKH_1485	1.428e-278	870.0	COG0651@1|root,COG0651@2|Bacteria,1MXRW@1224|Proteobacteria,2VMAN@28216|Betaproteobacteria,2KVTE@206389|Rhodocyclales	206389|Rhodocyclales	CP	Proton-conducting membrane transporter	hyfB	-	-	-	-	-	-	-	-	-	-	-	Proton_antipo_M
HKD3_k127_2522251_0	257310.BB0840	9.792e-286	894.0	COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,1MUBY@1224|Proteobacteria,2VH19@28216|Betaproteobacteria,3T1BH@506|Alcaligenaceae	28216|Betaproteobacteria	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g,tRNA_bind
HKD3_k127_2522251_2	1000565.METUNv1_02967	1.066e-176	559.0	COG0489@1|root,COG0489@2|Bacteria,1MU7R@1224|Proteobacteria,2VIMV@28216|Betaproteobacteria,2KV2W@206389|Rhodocyclales	206389|Rhodocyclales	D	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP	mrp	-	-	ko:K03593	-	-	-	-	ko00000,ko03029,ko03036	-	-	-	FeS_assembly_P,ParA
HKD3_k127_2522251_3	1163617.SCD_n01869	2.629e-104	361.0	COG0717@1|root,COG0717@2|Bacteria,1MV2J@1224|Proteobacteria,2VIJ0@28216|Betaproteobacteria	28216|Betaproteobacteria	F	Belongs to the dCTP deaminase family	dcd	-	3.5.4.13	ko:K01494	ko00240,ko01100,map00240,map01100	M00053	R00568,R02325	RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	dUTPase
HKD3_k127_2561670_5	420324.KI911961_gene1871	1.126e-13	71.0	COG0667@1|root,COG0667@2|Bacteria,1MVEH@1224|Proteobacteria,2TRHS@28211|Alphaproteobacteria,1JT1V@119045|Methylobacteriaceae	28211|Alphaproteobacteria	C	PFAM aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
HKD3_k127_2561670_4	867845.KI911784_gene3313	3.307e-52	186.0	COG3651@1|root,COG3651@2|Bacteria	2|Bacteria	G	Uncharacterized protein conserved in bacteria (DUF2237)	-	-	-	ko:K09966	-	-	-	-	ko00000	-	-	-	DUF2237
HKD3_k127_2561670_2	1123393.KB891330_gene871	2.043e-72	253.0	COG3134@1|root,COG3134@2|Bacteria,1MY27@1224|Proteobacteria,2VMUB@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Beta/gamma crystallins	-	-	-	-	-	-	-	-	-	-	-	-	Crystall,Rick_17kDa_Anti
HKD3_k127_2561670_1	1198452.Jab_1c02990	2.499e-101	343.0	COG1162@1|root,COG1162@2|Bacteria,1MUEF@1224|Proteobacteria,2VNB4@28216|Betaproteobacteria,474YM@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit	rsgA1	-	3.1.3.100	ko:K06949	ko00730,ko01100,map00730,map01100	-	R00615,R02135	RC00002,RC00017	ko00000,ko00001,ko01000,ko03009	-	-	-	RsgA_GTPase
HKD3_k127_2561670_0	762376.AXYL_04466	1.681e-287	901.0	COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,2VM2H@28216|Betaproteobacteria,3T57X@506|Alcaligenaceae	28216|Betaproteobacteria	L	Superfamily I DNA and RNA helicases	pcrA	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
HKD3_k127_2561670_3	338969.Rfer_0414	4.191e-54	199.0	COG1651@1|root,COG1651@2|Bacteria,1MVS2@1224|Proteobacteria,2VQH7@28216|Betaproteobacteria,4AGU8@80864|Comamonadaceae	28216|Betaproteobacteria	O	Thioredoxin	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_4
HKD3_k127_2625455_3	1121440.AUMA01000006_gene1597	1.956e-07	54.0	2EINH@1|root,33CDW@2|Bacteria,1NN5W@1224|Proteobacteria,42XC5@68525|delta/epsilon subdivisions,2WT26@28221|Deltaproteobacteria,2MDT2@213115|Desulfovibrionales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_2625455_2	640081.Dsui_0925	3.183e-23	116.0	COG0526@1|root,COG0526@2|Bacteria,1N728@1224|Proteobacteria,2VU78@28216|Betaproteobacteria,2KX1D@206389|Rhodocyclales	206389|Rhodocyclales	CO	Thioredoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_3
HKD3_k127_2625455_0	85643.Tmz1t_1855	2.058e-207	655.0	COG0701@1|root,COG0701@2|Bacteria,1MUN8@1224|Proteobacteria,2VNTF@28216|Betaproteobacteria,2KVB8@206389|Rhodocyclales	206389|Rhodocyclales	S	Predicted permease	-	-	-	ko:K07089	-	-	-	-	ko00000	-	-	-	ArsP_1
HKD3_k127_2625455_1	1242864.D187_007383	1.949e-56	204.0	COG2358@1|root,COG2358@2|Bacteria,1MWSG@1224|Proteobacteria,42NC8@68525|delta/epsilon subdivisions,2WK4Q@28221|Deltaproteobacteria,2YZCF@29|Myxococcales	28221|Deltaproteobacteria	S	NMT1-like family	-	-	-	ko:K07080	-	-	-	-	ko00000	-	-	-	NMT1_3
HKD3_k127_2734494_2	1031711.RSPO_c00142	7.578e-102	334.0	COG0407@1|root,COG0407@2|Bacteria,1MUG1@1224|Proteobacteria,2VHC2@28216|Betaproteobacteria,1K0MW@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	hemE	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
HKD3_k127_2734494_3	1122604.JONR01000061_gene2112	6.277e-94	316.0	2C1VH@1|root,2Z7Z3@2|Bacteria,1MY5B@1224|Proteobacteria,1RRVD@1236|Gammaproteobacteria,1X6GP@135614|Xanthomonadales	135614|Xanthomonadales	S	3-deoxy-D-manno-oct-2-ulosonic acid (Kdo) hydroxylase	-	-	-	-	-	-	-	-	-	-	-	-	Kdo_hydroxy
HKD3_k127_2734494_1	1159870.KB907784_gene1383	4.233e-243	767.0	COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,2VIHR@28216|Betaproteobacteria,3T34B@506|Alcaligenaceae	28216|Betaproteobacteria	C	provides electrons to the alpha subunit, which binds L-glutamine and 2-oxoglutarate and forms L-glutamate	gltD	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4_20,Pyr_redox_2
HKD3_k127_2734494_0	882378.RBRH_02313	1.744e-251	785.0	COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,2VHUY@28216|Betaproteobacteria,1K0VQ@119060|Burkholderiaceae	28216|Betaproteobacteria	E	glutamate synthase	gltB	-	1.4.1.13,1.4.1.14,1.4.7.1	ko:K00265,ko:K00284	ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230	-	R00021,R00093,R00114,R00248,R10086	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
HKD3_k127_2748853_1	1158292.JPOE01000005_gene1137	1.658e-167	529.0	COG2414@1|root,COG2414@2|Bacteria,1MWBB@1224|Proteobacteria,2VJ8P@28216|Betaproteobacteria,1KJ1B@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Aldehyde ferredoxin oxidoreductase	aorA	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
HKD3_k127_2748853_7	1121920.AUAU01000009_gene1912	3.497e-11	67.0	2EUZI@1|root,33NER@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_2748853_3	305700.B447_01751	6.257e-151	488.0	COG0446@1|root,COG0446@2|Bacteria,1NR3M@1224|Proteobacteria,2VKIS@28216|Betaproteobacteria,2KVRE@206389|Rhodocyclales	206389|Rhodocyclales	S	FAD-dependent pyridine	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2
HKD3_k127_2748853_5	1265502.KB905933_gene2064	1.218e-28	116.0	COG2104@1|root,COG2104@2|Bacteria,1N9VX@1224|Proteobacteria,2VVYE@28216|Betaproteobacteria,4AFRB@80864|Comamonadaceae	28216|Betaproteobacteria	H	PFAM thiamineS protein	-	-	-	-	-	-	-	-	-	-	-	-	ThiS,Ub-Mut7C
HKD3_k127_2748853_0	338969.Rfer_2223	6.176e-192	606.0	COG0446@1|root,COG0446@2|Bacteria,1NR3M@1224|Proteobacteria,2VJSV@28216|Betaproteobacteria,4AAZZ@80864|Comamonadaceae	28216|Betaproteobacteria	O	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,Reductase_C,Rieske
HKD3_k127_2748853_2	1071679.BG57_17795	2.172e-155	500.0	COG1975@1|root,COG1975@2|Bacteria,1MXKU@1224|Proteobacteria,2VHIK@28216|Betaproteobacteria,1K1XI@119060|Burkholderiaceae	28216|Betaproteobacteria	O	XdhC and CoxI family	pucA	-	-	ko:K07402	-	-	-	-	ko00000	-	-	-	XdhC_C,XdhC_CoxI
HKD3_k127_2748853_6	1121013.P873_08560	1.257e-14	84.0	COG0265@1|root,COG0265@2|Bacteria,1R61I@1224|Proteobacteria	1224|Proteobacteria	O	peptidase S1 and S6 chymotrypsin Hap	-	-	3.4.21.50	ko:K01337	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Trypsin,Trypsin_2
HKD3_k127_2748853_4	292415.Tbd_0828	7.989e-133	434.0	COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,2VH3F@28216|Betaproteobacteria,1KS3D@119069|Hydrogenophilales	28216|Betaproteobacteria	L	Bacterial DNA polymerase III alpha subunit	-	-	2.7.7.7	ko:K14162	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP
HKD3_k127_2769723_9	330214.NIDE2522	2.901e-135	453.0	COG2199@1|root,COG5001@1|root,COG3706@2|Bacteria,COG5001@2|Bacteria,3J10M@40117|Nitrospirae	40117|Nitrospirae	T	Putative diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF
HKD3_k127_2769723_2	56780.SYN_03643	2.108e-297	926.0	COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,42M4Z@68525|delta/epsilon subdivisions,2WJ0D@28221|Deltaproteobacteria,2MQTC@213462|Syntrophobacterales	28221|Deltaproteobacteria	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	-	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,Peptidase_M41
HKD3_k127_2769723_7	78245.Xaut_4065	2.203e-153	511.0	COG0154@1|root,COG0154@2|Bacteria,1MW3Z@1224|Proteobacteria,2TS56@28211|Alphaproteobacteria,3EY5Z@335928|Xanthobacteraceae	28211|Alphaproteobacteria	J	Amidase	-	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
HKD3_k127_2769723_12	1297865.APJD01000003_gene6138	6.626e-60	215.0	COG4798@1|root,COG4798@2|Bacteria,1NNHX@1224|Proteobacteria,2TVU9@28211|Alphaproteobacteria,3JUSH@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Ubie_methyltran
HKD3_k127_2769723_5	1288494.EBAPG3_21100	1.152e-198	632.0	COG0448@1|root,COG0448@2|Bacteria,1MVTC@1224|Proteobacteria,2VIP2@28216|Betaproteobacteria,372V3@32003|Nitrosomonadales	28216|Betaproteobacteria	H	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans	glgC	-	2.7.7.27	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	M00565	R00948	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
HKD3_k127_2769723_15	1123073.KB899241_gene1867	1.443e-10	76.0	COG3391@1|root,COG3391@2|Bacteria,1R7H9@1224|Proteobacteria,1SGRP@1236|Gammaproteobacteria,1X57E@135614|Xanthomonadales	135614|Xanthomonadales	S	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	Lactonase
HKD3_k127_2769723_10	1223523.H340_23763	1.498e-85	319.0	COG1376@1|root,COG2304@1|root,COG1376@2|Bacteria,COG2304@2|Bacteria,2GKPD@201174|Actinobacteria	201174|Actinobacteria	E	IgA Peptidase M64	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M64
HKD3_k127_2769723_16	221288.JH992900_gene300	2.334e-09	69.0	COG0642@1|root,COG0784@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,1G4NX@1117|Cyanobacteria,1JHPD@1189|Stigonemataceae	1117|Cyanobacteria	T	Domain of unknown function (DUF4118)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4118,HATPase_c,HisKA,PAS_9,Response_reg
HKD3_k127_2769723_13	686340.Metal_1050	3.091e-23	113.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1XDYH@135618|Methylococcales	135618|Methylococcales	T	Diguanylate cyclase phosphodiesterase with PAS PAC	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,Response_reg
HKD3_k127_2769723_4	864051.BurJ1DRAFT_4048	2.875e-209	670.0	COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,2VI60@28216|Betaproteobacteria,1KIU6@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	Gamma-glutamyltranspeptidase	ggt	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
HKD3_k127_2769723_6	85643.Tmz1t_2631	7.501e-166	543.0	COG3850@1|root,COG3850@2|Bacteria,1MWZT@1224|Proteobacteria,2VIFM@28216|Betaproteobacteria,2KV4T@206389|Rhodocyclales	206389|Rhodocyclales	T	Type IV pili methyl-accepting chemotaxis transducer N-term	-	-	2.7.13.3	ko:K07673	ko02020,map02020	M00471	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	GAF_2,HAMP,HATPase_c,HisKA_3,PilJ
HKD3_k127_2769723_11	748280.NH8B_1444	8.858e-75	261.0	COG2197@1|root,COG2197@2|Bacteria,1NQH7@1224|Proteobacteria,2VMXI@28216|Betaproteobacteria,2KQ15@206351|Neisseriales	206351|Neisseriales	K	Response regulator receiver domain protein	narL	-	-	ko:K07684	ko02020,map02020	M00471	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	GerE,Response_reg
HKD3_k127_2769723_3	543913.D521_0423	2.076e-215	675.0	COG2223@1|root,COG2223@2|Bacteria,1MU27@1224|Proteobacteria,2VI6Q@28216|Betaproteobacteria,1KQQE@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	P	Major Facilitator Superfamily	narK1	-	-	ko:K02575	ko00910,map00910	M00615	-	-	ko00000,ko00001,ko00002,ko02000	2.A.1.8	-	-	MFS_1
HKD3_k127_2769723_1	1223521.BBJX01000007_gene1576	7.83e-316	972.0	COG2223@1|root,COG2223@2|Bacteria,1MU27@1224|Proteobacteria,2VI5E@28216|Betaproteobacteria,4ABQV@80864|Comamonadaceae	28216|Betaproteobacteria	P	nitrite transporter	-	-	-	ko:K02575	ko00910,map00910	M00615	-	-	ko00000,ko00001,ko00002,ko02000	2.A.1.8	-	-	MFS_1
HKD3_k127_2769723_8	653733.Selin_2438	4.729e-141	462.0	COG2223@1|root,COG2223@2|Bacteria	2|Bacteria	P	nitrite transmembrane transporter activity	-	-	-	ko:K02575	ko00910,map00910	M00615	-	-	ko00000,ko00001,ko00002,ko02000	2.A.1.8	-	-	MFS_1
HKD3_k127_2769723_0	1437824.BN940_15761	0.0	1007.0	COG5013@1|root,COG5013@2|Bacteria,1MW9S@1224|Proteobacteria,2VJ2F@28216|Betaproteobacteria,3T1DU@506|Alcaligenaceae	28216|Betaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	narZ	-	1.7.5.1	ko:K00370,ko:K17050	ko00910,ko01120,ko02020,map00910,map01120,map02020	M00529,M00530,M00804	R00798,R01106,R09497	RC02812	ko00000,ko00001,ko00002,ko01000,ko02000	5.A.3.1,5.A.3.8	-	-	Molybdopterin,Molydop_binding,Nitr_red_alph_N
HKD3_k127_2791340_1	1276756.AUEX01000001_gene1070	7.587e-53	190.0	COG1894@1|root,COG1905@1|root,COG1894@2|Bacteria,COG1905@2|Bacteria,1MV8F@1224|Proteobacteria,2VIMM@28216|Betaproteobacteria,4AB8V@80864|Comamonadaceae	28216|Betaproteobacteria	C	PFAM Respiratory-chain NADH dehydrogenase domain, 51 kDa subunit	fdwB	-	1.17.1.9	ko:K00122	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	2Fe-2S_thioredx,Complex1_51K,NADH_4Fe-4S,SLBB
HKD3_k127_2791340_0	760117.JN27_03210	3.373e-299	939.0	COG3383@1|root,COG3383@2|Bacteria,1QTZB@1224|Proteobacteria,2VP2Q@28216|Betaproteobacteria,472B9@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	Molybdopterin oxidoreductase Fe4S4 domain	fdhA1	-	1.17.1.9,1.17.99.7	ko:K00123,ko:K22015	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Fer2_4,Fer4,Fer4_9,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
HKD3_k127_2897810_16	1380391.JIAS01000014_gene2355	1.52e-17	82.0	COG2216@1|root,COG2216@2|Bacteria,1MU7D@1224|Proteobacteria,2TREM@28211|Alphaproteobacteria,2JQRV@204441|Rhodospirillales	204441|Rhodospirillales	P	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system	kdpB	-	3.6.3.12	ko:K01547	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	3.A.3.7	-	-	E1-E2_ATPase,Hydrolase
HKD3_k127_2897810_13	983917.RGE_20700	1.091e-59	212.0	COG2156@1|root,COG2156@2|Bacteria,1RABG@1224|Proteobacteria,2VQ72@28216|Betaproteobacteria,1KM06@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex	kdpC	-	3.6.3.12	ko:K01548	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	3.A.3.7	-	-	KdpC
HKD3_k127_2897810_0	375286.mma_1820	7.647e-320	1003.0	COG0642@1|root,COG2205@2|Bacteria,1MUZQ@1224|Proteobacteria,2VH62@28216|Betaproteobacteria,4727F@75682|Oxalobacteraceae	28216|Betaproteobacteria	T	Domain of unknown function (DUF4118)	kdpD	-	2.7.13.3	ko:K07646	ko02020,map02020	M00454	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	DUF4118,GAF_3,HATPase_c,HisKA,KdpD,Usp
HKD3_k127_2897810_9	1123504.JQKD01000002_gene3640	3.11e-89	331.0	COG0745@1|root,COG0745@2|Bacteria,1MWZ5@1224|Proteobacteria,2VIM1@28216|Betaproteobacteria,4AAVM@80864|Comamonadaceae	28216|Betaproteobacteria	K	Two component transcriptional regulator, winged helix family	kdpE	-	-	ko:K07667	ko02020,ko02024,map02020,map02024	M00454	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
HKD3_k127_2897810_3	1157708.KB907462_gene884	6.649e-164	545.0	COG0277@1|root,COG0277@2|Bacteria,1N4UQ@1224|Proteobacteria,2W1U4@28216|Betaproteobacteria,4AHE1@80864|Comamonadaceae	28216|Betaproteobacteria	C	FAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_4
HKD3_k127_2897810_4	1158292.JPOE01000005_gene217	7.695e-152	505.0	COG2230@1|root,COG2230@2|Bacteria,1MX3U@1224|Proteobacteria,2VSBW@28216|Betaproteobacteria	28216|Betaproteobacteria	M	Mycolic acid cyclopropane synthetase	-	-	2.1.1.79	ko:K00574	-	-	-	-	ko00000,ko01000	-	-	-	CMAS
HKD3_k127_2897810_14	1156919.QWC_12426	8.61e-57	211.0	COG0400@1|root,COG0400@2|Bacteria,1RA02@1224|Proteobacteria,2VQID@28216|Betaproteobacteria,3T48U@506|Alcaligenaceae	28216|Betaproteobacteria	S	Phospholipase/Carboxylesterase	-	-	-	ko:K06999	-	-	-	-	ko00000	-	-	-	Abhydrolase_2
HKD3_k127_2897810_11	1300345.LF41_2713	1.33e-71	262.0	COG3384@1|root,COG3384@2|Bacteria,1MXJZ@1224|Proteobacteria,1RR5P@1236|Gammaproteobacteria,1X3A0@135614|Xanthomonadales	135614|Xanthomonadales	S	dioxygenase	-	-	-	ko:K15777	ko00965,map00965	-	R08836	RC00387	ko00000,ko00001,ko01000	-	-	-	LigB
HKD3_k127_2897810_15	1005048.CFU_4089	1.03e-39	156.0	COG2259@1|root,COG2259@2|Bacteria,1N06A@1224|Proteobacteria,2VU8E@28216|Betaproteobacteria,477WH@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	DoxX	-	-	-	ko:K15977	-	-	-	-	ko00000	-	-	-	DoxX
HKD3_k127_2897810_8	316273.XCV3828	1.638e-90	309.0	COG0583@1|root,COG0583@2|Bacteria,1MW16@1224|Proteobacteria,1RPNX@1236|Gammaproteobacteria,1X60Z@135614|Xanthomonadales	135614|Xanthomonadales	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HKD3_k127_2897810_12	357808.RoseRS_4350	1.045e-61	221.0	COG2045@1|root,COG2045@2|Bacteria,2G8Z5@200795|Chloroflexi	200795|Chloroflexi	H	Belongs to the ComB family	-	-	3.1.3.71	ko:K05979	ko00680,ko01120,map00680,map01120	M00358	R05789	RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	2-ph_phosp
HKD3_k127_2897810_17	2340.JV46_16940	1.132e-05	59.0	COG1141@1|root,COG1141@2|Bacteria	2|Bacteria	C	electron transfer activity	-	-	1.2.7.1	ko:K03737,ko:K05337	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00173,M00307	R01196,R10866	RC00004,RC02742	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_13,Fer4_6,PFOR_II,POR,POR_N,TPP_enzyme_C
HKD3_k127_2897810_10	1187851.A33M_4209	1.007e-87	321.0	COG1013@1|root,COG1013@2|Bacteria	2|Bacteria	C	oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_6,PFOR_II,POR,POR_N,TPP_enzyme_C
HKD3_k127_2897810_7	1049564.TevJSym_bb00040	6.665e-104	347.0	COG1013@1|root,COG1013@2|Bacteria,1R5BF@1224|Proteobacteria,1RZ7Y@1236|Gammaproteobacteria,1J5GQ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	COG1013 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases, beta subunit	korB	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
HKD3_k127_2897810_2	1049564.TevJSym_bb00050	7.952e-221	701.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,1NBSJ@1224|Proteobacteria,1S0WV@1236|Gammaproteobacteria,1J5KF@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases	korA	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR,POR_N
HKD3_k127_2897810_1	1187851.A33M_4208	2.39e-233	731.0	COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,2TSE2@28211|Alphaproteobacteria,3FCY5@34008|Rhodovulum	28211|Alphaproteobacteria	E	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	-	-	-	-	-	-	-	-	-	-	-	-	DHODB_Fe-S_bind,Fer4_20,Pyr_redox_2
HKD3_k127_2897810_5	1187851.A33M_4207	3.629e-151	482.0	COG0543@1|root,COG0543@2|Bacteria	2|Bacteria	C	2 iron, 2 sulfur cluster binding	gltA	-	1.18.1.2,1.19.1.1,1.4.1.13,1.4.1.14	ko:K00266,ko:K00528,ko:K02823	ko00240,ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00240,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248,R10159	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	DHODB_Fe-S_bind,FAD_binding_6,Fer4_20,NAD_binding_1,Pyr_redox_2
HKD3_k127_2897810_6	1123073.KB899242_gene1459	1.223e-150	481.0	COG1013@1|root,COG1013@2|Bacteria,1R5BF@1224|Proteobacteria,1RZ7Y@1236|Gammaproteobacteria,1X9AV@135614|Xanthomonadales	135614|Xanthomonadales	C	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain	-	-	-	-	-	-	-	-	-	-	-	-	TPP_enzyme_C
HKD3_k127_2930562_4	1500894.JQNN01000001_gene421	1.408e-14	74.0	COG3279@1|root,COG3279@2|Bacteria,1R9Q4@1224|Proteobacteria,2WEES@28216|Betaproteobacteria,473Y1@75682|Oxalobacteraceae	28216|Betaproteobacteria	KT	LytTr DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	LytTR,Response_reg
HKD3_k127_2930562_0	287.DR97_5776	1.953e-157	531.0	COG1629@1|root,COG4771@2|Bacteria,1MU9K@1224|Proteobacteria,1RMTG@1236|Gammaproteobacteria,1YKP0@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	P	TonB-dependent Receptor Plug Domain	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
HKD3_k127_2930562_5	1485544.JQKP01000001_gene1043	1.6e-11	73.0	COG2972@1|root,COG2972@2|Bacteria,1MXVQ@1224|Proteobacteria,2VRIK@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	His_kinase
HKD3_k127_2930562_1	983917.RGE_02720	2.799e-47	188.0	COG2972@1|root,COG2972@2|Bacteria,1R5R0@1224|Proteobacteria,2VM7Q@28216|Betaproteobacteria,1KN1G@119065|unclassified Burkholderiales	28216|Betaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,His_kinase
HKD3_k127_2930562_2	1217718.ALOU01000026_gene3563	1.488e-37	163.0	COG2972@1|root,COG2972@2|Bacteria,1MXVQ@1224|Proteobacteria,2VH9S@28216|Betaproteobacteria,1KA7Y@119060|Burkholderiaceae	28216|Betaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	2TM,His_kinase
HKD3_k127_2930562_3	189753.AXAS01000041_gene2534	8.669e-31	126.0	COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,2TSG1@28211|Alphaproteobacteria,3JSYZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
HKD3_k127_2954176_0	859657.RPSI07_2915	0.0	1802.0	COG0247@1|root,COG0277@1|root,COG1146@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,COG1146@2|Bacteria,1MU43@1224|Proteobacteria,2VHYU@28216|Betaproteobacteria,1K40G@119060|Burkholderiaceae	28216|Betaproteobacteria	C	FAD linked oxidase domain protein	glpCD	-	-	-	-	-	-	-	-	-	-	-	CCG,DUF3400,DUF3683,FAD-oxidase_C,FAD_binding_4,Fer4_8
HKD3_k127_2954176_3	1042375.AFPL01000036_gene2996	2.642e-07	58.0	COG2010@1|root,COG2010@2|Bacteria,1N71Z@1224|Proteobacteria,1SF76@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
HKD3_k127_2954176_1	1379270.AUXF01000003_gene3535	4.284e-153	496.0	COG1007@1|root,COG1007@2|Bacteria,1ZUR0@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	-	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
HKD3_k127_2954176_2	1379270.AUXF01000003_gene3534	5.937e-78	265.0	COG1008@1|root,COG1008@2|Bacteria,1ZUBB@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	Proton-conducting membrane transporter	-	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
HKD3_k127_300053_8	1304883.KI912532_gene2601	1.358e-66	236.0	COG0750@1|root,COG0750@2|Bacteria,1MU91@1224|Proteobacteria,2VHBW@28216|Betaproteobacteria,2KV3Y@206389|Rhodocyclales	206389|Rhodocyclales	M	zinc metalloprotease	-	-	-	ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_M50
HKD3_k127_300053_0	1149133.ppKF707_0690	5.329e-137	466.0	COG0743@1|root,COG0743@2|Bacteria,1MU4G@1224|Proteobacteria,1RNNW@1236|Gammaproteobacteria,1YE9E@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	I	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)	dxr	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016114,GO:0016491,GO:0016614,GO:0016616,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030145,GO:0030604,GO:0032787,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046490,GO:0046872,GO:0046914,GO:0048037,GO:0050661,GO:0050662,GO:0051483,GO:0051484,GO:0055114,GO:0070402,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901265,GO:1901363,GO:1901576	1.1.1.267	ko:K00099	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05688	RC01452	ko00000,ko00001,ko00002,ko01000	-	-	iAPECO1_1312.APECO1_1814,iECOK1_1307.ECOK1_0174,iECS88_1305.ECS88_0183,iUMN146_1321.UM146_23670,iUTI89_1310.UTI89_C0188	DXPR_C,DXP_redisom_C,DXP_reductoisom
HKD3_k127_300053_11	1348657.M622_07995	3.171e-56	207.0	COG0575@1|root,COG0575@2|Bacteria,1MWSV@1224|Proteobacteria,2VMM0@28216|Betaproteobacteria,2KW5H@206389|Rhodocyclales	206389|Rhodocyclales	I	Belongs to the CDS family	cdsA	-	2.7.7.41	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_1
HKD3_k127_300053_4	1231391.AMZF01000014_gene2301	1.009e-92	321.0	COG0020@1|root,COG0020@2|Bacteria,1MVP1@1224|Proteobacteria,2VH2E@28216|Betaproteobacteria,3T293@506|Alcaligenaceae	28216|Betaproteobacteria	H	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids	uppS	-	2.5.1.31	ko:K00806	ko00900,ko01110,map00900,map01110	-	R06447	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
HKD3_k127_300053_6	582744.Msip34_1408	1.887e-81	275.0	COG0233@1|root,COG0233@2|Bacteria,1N66T@1224|Proteobacteria,2VIUA@28216|Betaproteobacteria,2KM1Y@206350|Nitrosomonadales	206350|Nitrosomonadales	J	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another	frr	-	-	ko:K02838	-	-	-	-	ko00000,ko03012	-	-	-	RRF
HKD3_k127_300053_2	1163617.SCD_n01633	4.142e-109	376.0	COG0528@1|root,COG0528@2|Bacteria,1MV3N@1224|Proteobacteria,2VH8A@28216|Betaproteobacteria	28216|Betaproteobacteria	F	Catalyzes the reversible phosphorylation of UMP to UDP	pyrH	-	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
HKD3_k127_300053_3	1163617.SCD_n01634	4.997e-108	362.0	COG0264@1|root,COG0264@2|Bacteria,1MUS2@1224|Proteobacteria,2VHSG@28216|Betaproteobacteria	28216|Betaproteobacteria	J	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome	tsf	-	-	ko:K02357	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EF_TS
HKD3_k127_300053_1	305700.B447_05228	3.787e-124	404.0	COG0052@1|root,COG0052@2|Bacteria,1MU33@1224|Proteobacteria,2VI8V@28216|Betaproteobacteria,2KUV5@206389|Rhodocyclales	206389|Rhodocyclales	J	Belongs to the universal ribosomal protein uS2 family	rpsB	-	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
HKD3_k127_300053_12	381666.H16_A1567	5.379e-53	200.0	COG0354@1|root,COG0354@2|Bacteria,1N852@1224|Proteobacteria,2VK2D@28216|Betaproteobacteria,1K0KG@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Belongs to the GcvT family	ygfZ	-	-	ko:K06980	-	-	-	-	ko00000,ko03016	-	-	-	GCV_T,GCV_T_C
HKD3_k127_300053_16	497321.C664_01775	7.407e-11	74.0	2EPNT@1|root,33H9E@2|Bacteria,1NI6Z@1224|Proteobacteria,2VXVE@28216|Betaproteobacteria,2KZ8W@206389|Rhodocyclales	206389|Rhodocyclales	S	Domain of unknown function (DUF4936)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4936
HKD3_k127_300053_9	243231.GSU0792	1.67e-64	232.0	COG3332@1|root,COG3332@2|Bacteria,1RDBS@1224|Proteobacteria,42QS8@68525|delta/epsilon subdivisions,2WMV7@28221|Deltaproteobacteria,43SGZ@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Transport and Golgi organisation 2	-	-	-	-	-	-	-	-	-	-	-	-	TANGO2
HKD3_k127_300053_13	85643.Tmz1t_2507	1.869e-37	159.0	COG2153@1|root,COG2153@2|Bacteria,1MZ86@1224|Proteobacteria,2VMR6@28216|Betaproteobacteria,2KYZ6@206389|Rhodocyclales	206389|Rhodocyclales	S	n-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_10
HKD3_k127_300053_5	1437824.BN940_08706	5.005e-82	289.0	COG0590@1|root,COG1619@1|root,COG0590@2|Bacteria,COG1619@2|Bacteria,1MWIY@1224|Proteobacteria,2VHAS@28216|Betaproteobacteria,3T1BE@506|Alcaligenaceae	28216|Betaproteobacteria	V	proteins homologs of microcin C7 resistance protein MccF	ldcA	-	3.4.17.13	ko:K01297	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_S66
HKD3_k127_300053_10	1000565.METUNv1_00894	1.549e-61	216.0	COG0590@1|root,COG0590@2|Bacteria,1RGU0@1224|Proteobacteria,2VR60@28216|Betaproteobacteria,2KW90@206389|Rhodocyclales	206389|Rhodocyclales	FJ	Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)	tadA	-	3.5.4.33	ko:K11991	-	-	R10223	RC00477	ko00000,ko01000,ko03016	-	-	-	MafB19-deam
HKD3_k127_300053_15	697282.Mettu_3684	4.438e-16	86.0	2E3V1@1|root,32YSA@2|Bacteria,1N7HB@1224|Proteobacteria,1SF7K@1236|Gammaproteobacteria,1XGMP@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_300053_7	1123393.KB891316_gene1541	1.289e-78	269.0	COG2818@1|root,COG2818@2|Bacteria,1R9X5@1224|Proteobacteria,2VQC5@28216|Betaproteobacteria	28216|Betaproteobacteria	L	glycosylase	tag	-	3.2.2.20	ko:K01246	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Adenine_glyco
HKD3_k127_300053_14	543913.D521_1224	1.115e-27	111.0	COG0518@1|root,COG0519@1|root,COG0518@2|Bacteria,COG0519@2|Bacteria,1MU2A@1224|Proteobacteria,2VHNG@28216|Betaproteobacteria,1KPVT@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	F	Catalyzes the synthesis of GMP from XMP	guaA	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase,GMP_synt_C,NAD_synthase
HKD3_k127_3045247_16	1366050.N234_19195	1.356e-07	58.0	COG0842@1|root,COG0842@2|Bacteria,1MUH1@1224|Proteobacteria,2VH42@28216|Betaproteobacteria,1JZYY@119060|Burkholderiaceae	28216|Betaproteobacteria	V	Transport permease protein	yadH	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
HKD3_k127_3045247_3	640081.Dsui_1404	2.608e-121	399.0	COG1131@1|root,COG1131@2|Bacteria,1MUW7@1224|Proteobacteria,2VI81@28216|Betaproteobacteria,2KVD2@206389|Rhodocyclales	206389|Rhodocyclales	V	ABC-type multidrug transport system, ATPase component	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD3_k127_3045247_17	1101195.Meth11DRAFT_0326	1.085e-05	57.0	COG3113@1|root,COG3113@2|Bacteria,1NGIE@1224|Proteobacteria,2W81J@28216|Betaproteobacteria,2KNBR@206350|Nitrosomonadales	206350|Nitrosomonadales	S	STAS domain	-	-	-	ko:K07122	ko02010,map02010	M00210	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27.3	-	-	STAS_2
HKD3_k127_3045247_8	522306.CAP2UW1_0617	5.216e-59	222.0	COG2854@1|root,COG2854@2|Bacteria,1NKFA@1224|Proteobacteria,2VR85@28216|Betaproteobacteria,1KQ2C@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	Q	MlaC protein	ttg2D	-	-	ko:K07323	ko02010,map02010	M00210	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27.3	-	-	MlaC
HKD3_k127_3045247_7	388051.AUFE01000022_gene4791	2.812e-59	229.0	COG2853@1|root,COG2853@2|Bacteria,1MVX0@1224|Proteobacteria,2VQ97@28216|Betaproteobacteria,1K1I1@119060|Burkholderiaceae	28216|Betaproteobacteria	M	PFAM VacJ family lipoprotein	vacJ	-	-	ko:K04754	-	-	-	-	ko00000	-	-	-	MlaA
HKD3_k127_3045247_9	640081.Dsui_1400	6.926e-55	197.0	COG1463@1|root,COG1463@2|Bacteria,1NCUG@1224|Proteobacteria,2VRKR@28216|Betaproteobacteria,2KWBN@206389|Rhodocyclales	206389|Rhodocyclales	Q	ABC-type transport system involved in resistance to organic solvents, periplasmic component	-	-	-	ko:K02067	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaD
HKD3_k127_3045247_5	1123392.AQWL01000001_gene1546	4.428e-114	373.0	COG0767@1|root,COG0767@2|Bacteria,1MVPN@1224|Proteobacteria,2VI5T@28216|Betaproteobacteria,1KRYU@119069|Hydrogenophilales	119069|Hydrogenophilales	Q	Permease MlaE	-	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE
HKD3_k127_3045247_4	748247.AZKH_0744	5.108e-117	385.0	COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,2VJIA@28216|Betaproteobacteria,2KUXY@206389|Rhodocyclales	206389|Rhodocyclales	Q	ABC-type transport system involved in resistance to organic solvents, ATPase component	-	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
HKD3_k127_3045247_0	1163617.SCD_n00563	9.052e-213	679.0	COG0475@1|root,COG1226@1|root,COG0475@2|Bacteria,COG1226@2|Bacteria,1MV34@1224|Proteobacteria,2VHQQ@28216|Betaproteobacteria	28216|Betaproteobacteria	P	Belongs to the monovalent cation proton antiporter 2 (cpa2) transporter (TC 2.A.37) family	kefB	-	-	ko:K03455	-	-	-	-	ko00000	2.A.37	-	-	Na_H_Exchanger,TrkA_C,TrkA_N
HKD3_k127_3045247_2	1434929.X946_2123	1.506e-122	406.0	COG0517@1|root,COG0794@1|root,COG0517@2|Bacteria,COG0794@2|Bacteria,1MUXD@1224|Proteobacteria,2VI24@28216|Betaproteobacteria,1K0GY@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Belongs to the SIS family. GutQ KpsF subfamily	kdsD	-	5.3.1.13	ko:K06041	ko00540,ko01100,map00540,map01100	M00063	R01530	RC00541	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CBS,SIS
HKD3_k127_3045247_12	1123392.AQWL01000004_gene2762	1.44e-40	169.0	COG1778@1|root,COG1778@2|Bacteria,1RH85@1224|Proteobacteria,2VRQX@28216|Betaproteobacteria,1KSY1@119069|Hydrogenophilales	119069|Hydrogenophilales	S	3-deoxy-D-manno-octulosonate 8-phosphate phosphatase, YrbI family	-	-	3.1.3.45	ko:K03270	ko00540,ko01100,map00540,map01100	M00063	R03350	RC00017	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hydrolase_3
HKD3_k127_3045247_14	1236959.BAMT01000006_gene329	8.16e-35	140.0	COG3117@1|root,COG3117@2|Bacteria,1R5UK@1224|Proteobacteria,2VU37@28216|Betaproteobacteria,2KMR4@206350|Nitrosomonadales	206350|Nitrosomonadales	S	Lipopolysaccharide-assembly, LptC-related	-	-	-	ko:K11719	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	LptC
HKD3_k127_3045247_13	1163617.SCD_n00559	3.497e-35	151.0	COG1934@1|root,COG1934@2|Bacteria,1N776@1224|Proteobacteria,2VSI4@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane	lptA	-	-	ko:K09774	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	OstA
HKD3_k127_3045247_6	1123367.C666_16175	5.506e-111	376.0	COG1137@1|root,COG1137@2|Bacteria,1MU8M@1224|Proteobacteria,2VH29@28216|Betaproteobacteria,2KUNS@206389|Rhodocyclales	206389|Rhodocyclales	S	ABC-type (Unclassified) transport system, ATPase component	-	-	-	ko:K06861	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	1.B.42.1	-	-	ABC_tran,BCA_ABC_TP_C
HKD3_k127_3045247_1	1123393.KB891328_gene576	1.656e-169	546.0	COG1508@1|root,COG1508@2|Bacteria,1MW4V@1224|Proteobacteria,2VIEV@28216|Betaproteobacteria,1KRAY@119069|Hydrogenophilales	119069|Hydrogenophilales	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	-	-	-	ko:K03092	ko02020,ko05111,map02020,map05111	-	-	-	ko00000,ko00001,ko03021	-	-	-	Sigma54_AID,Sigma54_CBD,Sigma54_DBD
HKD3_k127_3045247_15	1120999.JONM01000010_gene4058	1.055e-33	150.0	COG1544@1|root,COG1544@2|Bacteria,1MZHW@1224|Proteobacteria,2VU5H@28216|Betaproteobacteria,2KRN2@206351|Neisseriales	206351|Neisseriales	J	ribosomal subunit interface protein	raiA	-	-	ko:K05808	-	-	-	-	ko00000,ko03009	-	-	-	Ribosomal_S30AE
HKD3_k127_3045247_10	640081.Dsui_0702	4.459e-51	186.0	COG1762@1|root,COG1762@2|Bacteria,1RD0E@1224|Proteobacteria,2VRDH@28216|Betaproteobacteria,2KW4R@206389|Rhodocyclales	206389|Rhodocyclales	G	COG1762 Phosphotransferase system mannitol fructose-specific IIA domain (Ntr-type)	ptsN	-	-	ko:K02806	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	-	-	-	PTS_EIIA_2
HKD3_k127_3045247_11	1163617.SCD_n00554	1.922e-45	173.0	COG1493@1|root,COG1493@2|Bacteria,1NNN5@1224|Proteobacteria,2VJCH@28216|Betaproteobacteria	28216|Betaproteobacteria	F	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr)	hprK	-	-	ko:K06023	-	-	-	-	ko00000,ko01000	-	-	-	Hpr_kinase_C,Hpr_kinase_N
HKD3_k127_304627_3	1031711.RSPO_c00606	3.997e-137	439.0	COG0216@1|root,COG0216@2|Bacteria,1MV28@1224|Proteobacteria,2VJKV@28216|Betaproteobacteria,1K2D1@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA	prfA	-	-	ko:K02835	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
HKD3_k127_304627_19	981369.JQMJ01000004_gene1634	3.461e-32	134.0	COG1670@1|root,COG1670@2|Bacteria,2GP87@201174|Actinobacteria,2NIVH@228398|Streptacidiphilus	201174|Actinobacteria	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
HKD3_k127_304627_21	929712.KI912613_gene2911	7.622e-23	109.0	COG1670@1|root,COG1670@2|Bacteria,2GP87@201174|Actinobacteria,4CQI4@84995|Rubrobacteria	84995|Rubrobacteria	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
HKD3_k127_304627_11	1122185.N792_03085	1.096e-75	271.0	COG2890@1|root,COG2890@2|Bacteria,1MXCQ@1224|Proteobacteria,1RNGK@1236|Gammaproteobacteria,1X4AP@135614|Xanthomonadales	135614|Xanthomonadales	J	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif	prmC	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0016740,GO:0016741,GO:0018364,GO:0019538,GO:0032259,GO:0036009,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0140096,GO:1901564	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS,Methyltransf_31
HKD3_k127_304627_18	1249627.D779_0950	1.733e-36	143.0	2E4R1@1|root,32ZJK@2|Bacteria,1N8FZ@1224|Proteobacteria,1S42H@1236|Gammaproteobacteria,1WYUX@135613|Chromatiales	135613|Chromatiales	S	Nitrous oxide-stimulated promoter	-	-	-	-	-	-	-	-	-	-	-	-	YgbA_NO
HKD3_k127_304627_4	1097668.BYI23_C003270	3.558e-119	394.0	COG2055@1|root,COG2055@2|Bacteria,1MWQY@1224|Proteobacteria,2VME1@28216|Betaproteobacteria,1K3NF@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Belongs to the LDH2 MDH2 oxidoreductase family	-	-	1.1.1.27	ko:K00016	ko00010,ko00270,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko04922,map00010,map00270,map00620,map00640,map01100,map01110,map01120,map01130,map04922	-	R00703,R01000,R03104	RC00031,RC00044	ko00000,ko00001,ko01000,ko04147	-	-	-	Ldh_2
HKD3_k127_304627_16	1536773.R70331_28790	2.061e-50	193.0	COG3836@1|root,COG3836@2|Bacteria,1UZZG@1239|Firmicutes,4HEP6@91061|Bacilli,26X7G@186822|Paenibacillaceae	91061|Bacilli	G	Belongs to the HpcH HpaI aldolase family	-	-	4.1.2.20,4.1.2.52	ko:K01630,ko:K02510	ko00053,ko00350,ko01120,map00053,map00350,map01120	-	R01645,R01647,R02754,R03277	RC00307,RC00435,RC00572,RC00574,RC03057	ko00000,ko00001,ko01000	-	-	-	HpcH_HpaI
HKD3_k127_304627_13	626418.bglu_1g07390	2.461e-64	234.0	COG1216@1|root,COG1216@2|Bacteria,1RFK0@1224|Proteobacteria,2VUIZ@28216|Betaproteobacteria,1JZUE@119060|Burkholderiaceae	28216|Betaproteobacteria	S	glycosyl transferase	wbiF	-	-	ko:K07011	-	-	-	-	ko00000	-	-	-	Glyco_tranf_2_3,Glycos_transf_2
HKD3_k127_304627_12	1123392.AQWL01000001_gene1561	1.333e-67	246.0	COG0451@1|root,COG0451@2|Bacteria,1MX2J@1224|Proteobacteria,2VJHC@28216|Betaproteobacteria,1KTE1@119069|Hydrogenophilales	119069|Hydrogenophilales	M	Male sterility protein	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
HKD3_k127_304627_7	859657.RPSI07_1265	5.321e-102	342.0	COG0689@1|root,COG0689@2|Bacteria,1MVFZ@1224|Proteobacteria,2VIGI@28216|Betaproteobacteria,1K0EK@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates	rph	-	2.7.7.56	ko:K00989	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RNase_PH,RNase_PH_C
HKD3_k127_304627_10	1123393.KB891328_gene517	3.108e-78	276.0	COG0127@1|root,COG0127@2|Bacteria,1MUK5@1224|Proteobacteria,2VQ1Z@28216|Betaproteobacteria,1KRM5@119069|Hydrogenophilales	119069|Hydrogenophilales	F	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions	-	-	3.6.1.66	ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000	-	-	-	Ham1p_like
HKD3_k127_304627_2	342113.DM82_2209	3.826e-158	522.0	COG0635@1|root,COG0635@2|Bacteria,1MU76@1224|Proteobacteria,2VHBB@28216|Betaproteobacteria,1K01J@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Involved in the biosynthesis of porphyrin-containing compound	hemN2	-	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
HKD3_k127_304627_17	670292.JH26_28055	7.693e-50	185.0	COG3703@1|root,COG3703@2|Bacteria,1QA7D@1224|Proteobacteria,2U84Q@28211|Alphaproteobacteria,1JSHZ@119045|Methylobacteriaceae	28211|Alphaproteobacteria	P	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides	-	-	-	ko:K07232	-	-	-	-	ko00000	-	-	-	ChaC
HKD3_k127_304627_1	987059.RBXJA2T_11807	1.349e-173	556.0	COG4198@1|root,COG4198@2|Bacteria,1R9HY@1224|Proteobacteria,2VZEY@28216|Betaproteobacteria,1KNFU@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Protein of unknown function (DUF1015)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1015
HKD3_k127_304627_23	84531.JMTZ01000002_gene778	5.635e-11	65.0	COG1075@1|root,COG1075@2|Bacteria,1R88U@1224|Proteobacteria,1S0MF@1236|Gammaproteobacteria,1X6S0@135614|Xanthomonadales	135614|Xanthomonadales	S	PGAP1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	PGAP1
HKD3_k127_304627_20	1535287.JP74_15630	4.137e-26	109.0	COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,2UF6W@28211|Alphaproteobacteria,3N78I@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	'Cold-shock' DNA-binding domain	-	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
HKD3_k127_304627_22	1163617.SCD_n01558	1.615e-13	77.0	COG2345@1|root,COG2345@2|Bacteria,1N9W3@1224|Proteobacteria,2VWG0@28216|Betaproteobacteria	28216|Betaproteobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_304627_5	1232410.KI421421_gene3631	5.149e-115	384.0	COG3202@1|root,COG3202@2|Bacteria,1MVP5@1224|Proteobacteria,42MNS@68525|delta/epsilon subdivisions,2WSQX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	ATP ADP translocase	-	-	-	ko:K03301	-	-	-	-	ko00000	2.A.12	-	-	MFS_1,TLC
HKD3_k127_304627_8	1123392.AQWL01000006_gene565	1.328e-98	327.0	COG1028@1|root,COG1028@2|Bacteria,1MUUV@1224|Proteobacteria,2VK0U@28216|Betaproteobacteria,1KRK0@119069|Hydrogenophilales	119069|Hydrogenophilales	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.5.1.33	ko:K03793	-	-	-	-	ko00000,ko01000	-	-	-	adh_short_C2
HKD3_k127_304627_6	76114.ebA3370	1.655e-113	378.0	COG1565@1|root,COG1565@2|Bacteria,1N3CJ@1224|Proteobacteria,2VHBE@28216|Betaproteobacteria,2KUAS@206389|Rhodocyclales	206389|Rhodocyclales	S	Putative S-adenosyl-L-methionine-dependent methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_28
HKD3_k127_304627_0	1454004.AW11_00511	1.176e-183	609.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2VHEI@28216|Betaproteobacteria,1KQHG@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	IQ	AMP-binding enzyme C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
HKD3_k127_304627_15	1437824.BN940_09791	7.809e-55	194.0	COG0346@1|root,COG0346@2|Bacteria,1RH3J@1224|Proteobacteria,2VRD4@28216|Betaproteobacteria,3T49M@506|Alcaligenaceae	28216|Betaproteobacteria	E	Lactoylglutathione lyase	gloA3	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HKD3_k127_304627_14	234267.Acid_1878	4.252e-55	196.0	COG4319@1|root,COG4319@2|Bacteria,3Y90I@57723|Acidobacteria	57723|Acidobacteria	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_304627_9	113395.AXAI01000035_gene44	2.081e-93	317.0	COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,2TSG1@28211|Alphaproteobacteria,3JYHD@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
HKD3_k127_3065318_1	404589.Anae109_1167	1.856e-157	515.0	COG1502@1|root,COG1502@2|Bacteria,1MWUW@1224|Proteobacteria,42PV9@68525|delta/epsilon subdivisions,2WKF2@28221|Deltaproteobacteria,2YXVH@29|Myxococcales	28221|Deltaproteobacteria	I	Phospholipase D. Active site motifs.	-	-	-	ko:K06131	ko00564,ko01100,map00564,map01100	-	R07390	RC00017	ko00000,ko00001,ko01000	-	-	-	PLDc_2
HKD3_k127_3065318_7	358220.C380_07865	8.109e-49	182.0	COG2755@1|root,COG2755@2|Bacteria,1RHDZ@1224|Proteobacteria,2WEFV@28216|Betaproteobacteria,4AHUJ@80864|Comamonadaceae	28216|Betaproteobacteria	E	Lysophospholipase L1 and related esterases	-	-	3.1.2.20	ko:K01073	-	-	-	-	ko00000,ko01000	-	-	-	Lipase_GDSL_2
HKD3_k127_3065318_6	1163617.SCD_n01762	1.661e-80	275.0	COG1926@1|root,COG1926@2|Bacteria,1RAG8@1224|Proteobacteria,2VPNZ@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Phosphoribosyl transferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Pribosyltran
HKD3_k127_3065318_10	243233.MCA1031	7.706e-29	121.0	COG1544@1|root,COG1544@2|Bacteria,1RJ55@1224|Proteobacteria,1S5AA@1236|Gammaproteobacteria,1XFBJ@135618|Methylococcales	135618|Methylococcales	J	Sigma 54 modulation protein / S30EA ribosomal protein	-	-	-	-	-	-	-	-	-	-	-	-	Ribosomal_S30AE
HKD3_k127_3065318_2	1538295.JY96_09220	6.287e-156	514.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,2VKJ8@28216|Betaproteobacteria,1KJ47@119065|unclassified Burkholderiales	28216|Betaproteobacteria	KLT	PFAM Protein kinase	-	-	2.7.11.1	ko:K11912,ko:K12132	ko02025,ko03070,map02025,map03070	-	-	-	ko00000,ko00001,ko01000,ko01001,ko02044	-	-	-	HAMP,Pkinase
HKD3_k127_3065318_5	1288494.EBAPG3_5880	3.4e-85	297.0	COG0726@1|root,COG0726@2|Bacteria,1MVKH@1224|Proteobacteria,2VIWN@28216|Betaproteobacteria,372SU@32003|Nitrosomonadales	28216|Betaproteobacteria	G	Polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
HKD3_k127_3065318_9	1538295.JY96_09235	5.485e-32	139.0	COG1652@1|root,COG1652@2|Bacteria,1RJQP@1224|Proteobacteria,2VWKC@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Lysin motif	-	-	-	-	-	-	-	-	-	-	-	-	LysM
HKD3_k127_3065318_8	1163617.SCD_n01748	1.12e-39	159.0	COG0671@1|root,COG0671@2|Bacteria,1NAJ7@1224|Proteobacteria,2VX11@28216|Betaproteobacteria	28216|Betaproteobacteria	I	Acid phosphatase homologues	-	-	-	-	-	-	-	-	-	-	-	-	PAP2
HKD3_k127_3065318_3	62928.azo2162	2.117e-123	425.0	COG1807@1|root,COG1807@2|Bacteria,1NMIZ@1224|Proteobacteria,2VMHK@28216|Betaproteobacteria,2KVVG@206389|Rhodocyclales	206389|Rhodocyclales	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HKD3_k127_3065318_4	631362.Thi970DRAFT_04737	1.705e-122	407.0	COG0463@1|root,COG0463@2|Bacteria,1MWE5@1224|Proteobacteria,1RPCE@1236|Gammaproteobacteria,1WXFS@135613|Chromatiales	135613|Chromatiales	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HKD3_k127_3065318_11	998674.ATTE01000001_gene3549	2.003e-15	88.0	COG0392@1|root,COG0392@2|Bacteria,1R5YC@1224|Proteobacteria,1S815@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Lysylphosphatidylglycerol synthase TM region	-	-	-	-	-	-	-	-	-	-	-	-	LPG_synthase_TM
HKD3_k127_3065318_0	497964.CfE428DRAFT_0631	7.497e-165	552.0	COG2114@1|root,COG3903@1|root,COG2114@2|Bacteria,COG3903@2|Bacteria,46TZ3@74201|Verrucomicrobia	74201|Verrucomicrobia	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,NB-ARC
HKD3_k127_320182_0	94624.Bpet0633	0.0	1395.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHFI@28216|Betaproteobacteria,3T1NA@506|Alcaligenaceae	28216|Betaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	bepE_2	-	-	ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
HKD3_k127_320182_6	94624.Bpet0632	1.726e-105	357.0	COG0845@1|root,COG0845@2|Bacteria,1MUFW@1224|Proteobacteria,2VKCK@28216|Betaproteobacteria,3T39E@506|Alcaligenaceae	28216|Betaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	mdtA_2	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	HlyD_D23
HKD3_k127_320182_7	795666.MW7_0585	4.692e-100	341.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VHK8@28216|Betaproteobacteria,1K6UF@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HKD3_k127_320182_4	795666.MW7_0585	7.492e-122	399.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VHK8@28216|Betaproteobacteria,1K6UF@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HKD3_k127_320182_3	365046.Rta_34780	7.529e-128	421.0	COG3181@1|root,COG3181@2|Bacteria,1P88K@1224|Proteobacteria,2VJJP@28216|Betaproteobacteria,4AJD9@80864|Comamonadaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HKD3_k127_320182_11	1000565.METUNv1_00439	2.212e-31	130.0	COG2363@1|root,COG2363@2|Bacteria,1MZX3@1224|Proteobacteria,2VW3M@28216|Betaproteobacteria,2KX9W@206389|Rhodocyclales	206389|Rhodocyclales	S	Protein of unknown function (DUF423)	-	-	-	-	-	-	-	-	-	-	-	-	DUF423
HKD3_k127_320182_10	1205753.A989_15182	4.163e-33	137.0	COG0251@1|root,COG0251@2|Bacteria,1MZ5K@1224|Proteobacteria,1S5WM@1236|Gammaproteobacteria,1X6UX@135614|Xanthomonadales	135614|Xanthomonadales	J	translation initiation inhibitor, yjgF family	-	-	-	-	-	-	-	-	-	-	-	-	Ribonuc_L-PSP
HKD3_k127_320182_2	1523503.JPMY01000036_gene1471	2.871e-160	516.0	COG4992@1|root,COG4992@2|Bacteria,1MV3C@1224|Proteobacteria,1RMV1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	aminotransferase	argD	GO:0003674,GO:0003824,GO:0003992,GO:0004069,GO:0005488,GO:0005515,GO:0006082,GO:0006105,GO:0006520,GO:0006525,GO:0006526,GO:0006527,GO:0006553,GO:0006591,GO:0006593,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009016,GO:0009056,GO:0009058,GO:0009063,GO:0009064,GO:0009065,GO:0009066,GO:0009067,GO:0009084,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016054,GO:0016740,GO:0016769,GO:0017144,GO:0019545,GO:0019752,GO:0019842,GO:0030170,GO:0033359,GO:0036094,GO:0042450,GO:0042802,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043825,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0046394,GO:0046395,GO:0046451,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607	2.6.1.11,2.6.1.17,2.6.1.81	ko:K00821,ko:K00840	ko00220,ko00300,ko00330,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map00330,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R02283,R04217,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	iAPECO1_1312.APECO1_817,iEC55989_1330.EC55989_1916,iECABU_c1320.ECABU_c20050,iECED1_1282.ECED1_1950,iECOK1_1307.ECOK1_1868,iECP_1309.ECP_1694,iECS88_1305.ECS88_1800,iEcSMS35_1347.EcSMS35_1443,iSFV_1184.SFV_3365,iSF_1195.SF3378,iSFxv_1172.SFxv_3689,iSSON_1240.SSON_3490,iS_1188.S4385,iUMN146_1321.UM146_08405,iUTI89_1310.UTI89_C1943,ic_1306.c2148	Aminotran_3
HKD3_k127_320182_5	1283284.AZUK01000001_gene154	4.327e-118	389.0	COG3138@1|root,COG3138@2|Bacteria,1MWHC@1224|Proteobacteria,1RMXG@1236|Gammaproteobacteria,1Y3SG@135624|Aeromonadales	135624|Aeromonadales	E	Arginine N-succinyltransferase beta subunit	astA	-	2.3.1.109	ko:K00673	ko00330,ko01100,map00330,map01100	-	R00832	RC00004,RC00064	ko00000,ko00001,ko01000	-	-	-	AstA
HKD3_k127_320182_1	42565.FP66_01060	3.919e-162	524.0	COG3724@1|root,COG3724@2|Bacteria,1MUJV@1224|Proteobacteria,1RNSS@1236|Gammaproteobacteria,1XH87@135619|Oceanospirillales	135619|Oceanospirillales	E	Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2)	astB	-	3.5.3.23	ko:K01484	ko00330,ko01100,map00330,map01100	-	R04189	RC00024	ko00000,ko00001,ko01000	-	-	-	AstB
HKD3_k127_320182_8	1121033.AUCF01000001_gene1954	4.436e-72	256.0	COG2872@1|root,COG2872@2|Bacteria,1MY0P@1224|Proteobacteria,2TRRW@28211|Alphaproteobacteria,2JPPZ@204441|Rhodospirillales	204441|Rhodospirillales	S	metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain	-	-	-	ko:K07050	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA-synt_2c,tRNA_SAD
HKD3_k127_320182_9	243233.MCA0638	6.917e-45	187.0	COG2930@1|root,COG2930@2|Bacteria,1RHV6@1224|Proteobacteria,1SDNN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Las17-binding protein actin regulator	-	-	-	-	-	-	-	-	-	-	-	-	Ysc84
HKD3_k127_3256084_13	317025.Tcr_0068	4.342e-09	63.0	COG2067@1|root,COG2067@2|Bacteria,1MUU4@1224|Proteobacteria,1RQZJ@1236|Gammaproteobacteria,46005@72273|Thiotrichales	72273|Thiotrichales	I	Long-chain fatty acid transport protein	-	-	-	ko:K06076	-	-	-	-	ko00000,ko02000	1.B.9	-	-	Toluene_X
HKD3_k127_3256084_10	1304883.KI912532_gene447	8.151e-47	171.0	COG1607@1|root,COG1607@2|Bacteria,1MZAZ@1224|Proteobacteria,2VR9M@28216|Betaproteobacteria,2KWTN@206389|Rhodocyclales	206389|Rhodocyclales	I	Thioesterase superfamily	-	-	-	ko:K10806	ko01040,map01040	-	-	-	ko00000,ko00001,ko01000,ko01004	-	-	-	4HBT
HKD3_k127_3256084_1	305700.B447_01271	1.643e-255	799.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2VI0I@28216|Betaproteobacteria,2KUXQ@206389|Rhodocyclales	206389|Rhodocyclales	IQ	COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
HKD3_k127_3256084_2	748247.AZKH_4266	2.22e-249	786.0	COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,2VH0Y@28216|Betaproteobacteria,2KU6T@206389|Rhodocyclales	206389|Rhodocyclales	I	3-hydroxyacyl-CoA dehydrogenase	-	-	1.1.1.35,4.2.1.17,5.1.2.3	ko:K01782	ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212	M00032,M00087	R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094	RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	3HCDH,3HCDH_N,ECH_1
HKD3_k127_3256084_3	748247.AZKH_4267	6.23e-216	679.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2VMHS@28216|Betaproteobacteria,2KUQ2@206389|Rhodocyclales	206389|Rhodocyclales	I	Belongs to the thiolase family	fadA	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
HKD3_k127_3256084_0	1000565.METUNv1_02311	0.0	1079.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2VKIW@28216|Betaproteobacteria,2KV4W@206389|Rhodocyclales	206389|Rhodocyclales	I	AcyL-CoA dehydrogenase	fadE	-	-	ko:K06445	ko00071,ko01100,ko01212,map00071,map01100,map01212	M00087	R01175,R01279,R03777,R03857,R03990,R04751,R04754	RC00052,RC00076	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_N,DUF1974
HKD3_k127_3256084_8	395019.Bmul_1719	5.702e-62	237.0	COG1309@1|root,COG1309@2|Bacteria,1RDIM@1224|Proteobacteria,2VJQ5@28216|Betaproteobacteria,1K1H5@119060|Burkholderiaceae	28216|Betaproteobacteria	K	PFAM regulatory protein TetR	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
HKD3_k127_3256084_9	189753.AXAS01000012_gene4337	9.205e-56	209.0	COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,2TSG1@28211|Alphaproteobacteria,3JSYZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
HKD3_k127_3256084_4	224911.27351119	4.375e-134	465.0	COG2203@1|root,COG4191@1|root,COG5002@1|root,COG2203@2|Bacteria,COG4191@2|Bacteria,COG5002@2|Bacteria,1RCM9@1224|Proteobacteria,2TTJ0@28211|Alphaproteobacteria,3K6MV@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Cache domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HAMP,HATPase_c,HisKA,dCache_1
HKD3_k127_3256084_12	395495.Lcho_0046	4.155e-37	145.0	COG0745@1|root,COG0745@2|Bacteria,1RD7E@1224|Proteobacteria,2VVWD@28216|Betaproteobacteria,1KPCJ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	T	PFAM response regulator receiver	-	-	-	ko:K11443	ko02020,ko04112,map02020,map04112	M00511	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg
HKD3_k127_3256084_5	395495.Lcho_0045	2.495e-128	426.0	COG2114@1|root,COG3437@1|root,COG2114@2|Bacteria,COG3437@2|Bacteria,1QY14@1224|Proteobacteria,2WH9F@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Belongs to the adenylyl cyclase class-4 guanylyl cyclase family	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc,Response_reg
HKD3_k127_3256084_11	1510531.JQJJ01000010_gene2373	1.853e-46	182.0	COG1611@1|root,COG1611@2|Bacteria,1RJ91@1224|Proteobacteria,2U9RN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Possible lysine decarboxylase	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
HKD3_k127_3256084_6	864051.BurJ1DRAFT_4038	8.217e-81	287.0	COG0464@1|root,COG0464@2|Bacteria,1RFP5@1224|Proteobacteria	1224|Proteobacteria	O	ATPase family associated with various cellular activities (AAA)	-	-	-	-	-	-	-	-	-	-	-	-	AAA,BCS1_N
HKD3_k127_3256084_7	342113.DM82_3521	4.749e-68	243.0	COG1512@1|root,COG1512@2|Bacteria,1PB41@1224|Proteobacteria,2VMNV@28216|Betaproteobacteria,1K55Q@119060|Burkholderiaceae	28216|Betaproteobacteria	S	TPM domain	-	-	-	ko:K06872	-	-	-	-	ko00000	-	-	-	TPM_phosphatase
HKD3_k127_3288630_0	243233.MCA2543	2.668e-212	670.0	COG0209@1|root,COG1372@1|root,COG0209@2|Bacteria,COG1372@2|Bacteria,1MUJ8@1224|Proteobacteria,1RQUR@1236|Gammaproteobacteria,1XE1A@135618|Methylococcales	135618|Methylococcales	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	-	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_lgC,Ribonuc_red_lgN
HKD3_k127_335241_3	1116369.KB890024_gene4677	6.625e-64	223.0	COG3837@1|root,COG3837@2|Bacteria,1NDXV@1224|Proteobacteria,2UCF8@28211|Alphaproteobacteria,43MJR@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HKD3_k127_335241_4	296591.Bpro_0144	1.05e-57	216.0	COG0346@1|root,COG0346@2|Bacteria,1RHD4@1224|Proteobacteria,2VSJM@28216|Betaproteobacteria,4AEJT@80864|Comamonadaceae	28216|Betaproteobacteria	E	PFAM Glyoxalase bleomycin resistance protein dioxygenase	-	-	-	ko:K08234	-	-	-	-	ko00000	-	-	-	Glyoxalase
HKD3_k127_335241_5	402881.Plav_2239	1.591e-26	116.0	2ERA8@1|root,33IVV@2|Bacteria,1NMXG@1224|Proteobacteria,2UKSQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_335241_1	987059.RBXJA2T_05258	3.854e-163	537.0	COG1902@1|root,COG1902@2|Bacteria,1MVIX@1224|Proteobacteria,2VH2S@28216|Betaproteobacteria,1KJIJ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	NADH flavin oxidoreductase NADH oxidase	nemA	GO:0000003,GO:0000302,GO:0001101,GO:0003006,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0006082,GO:0006950,GO:0006979,GO:0007275,GO:0008150,GO:0008152,GO:0009058,GO:0009605,GO:0009607,GO:0009620,GO:0009694,GO:0009695,GO:0009791,GO:0009908,GO:0009987,GO:0010035,GO:0010193,GO:0010817,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0016629,GO:0019752,GO:0022414,GO:0032501,GO:0032502,GO:0032787,GO:0042221,GO:0042445,GO:0042446,GO:0042493,GO:0042579,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046677,GO:0048367,GO:0048437,GO:0048438,GO:0048443,GO:0048466,GO:0048608,GO:0048731,GO:0048827,GO:0048856,GO:0050896,GO:0051704,GO:0051707,GO:0055114,GO:0061458,GO:0065007,GO:0065008,GO:0071704,GO:0072330,GO:0090567,GO:0099402,GO:1901576,GO:1901700	-	ko:K10680	ko00633,ko01120,map00633,map01120	-	R08014,R08017,R08042	RC00250	ko00000,ko00001,ko01000	-	-	-	Oxidored_FMN
HKD3_k127_335241_0	640081.Dsui_0441	4.56e-199	631.0	COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,2VI29@28216|Betaproteobacteria,2KUHE@206389|Rhodocyclales	206389|Rhodocyclales	P	Acts as a magnesium transporter	mgtE	-	-	ko:K06213	-	-	-	-	ko00000,ko02000	1.A.26.1	-	-	CBS,MgtE,MgtE_N
HKD3_k127_335241_2	522306.CAP2UW1_0286	4.473e-90	303.0	COG0744@1|root,COG0744@2|Bacteria,1RDAQ@1224|Proteobacteria,2VHW8@28216|Betaproteobacteria,1KQVK@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	M	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors	mtgA	-	2.4.1.129	ko:K03814	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly
HKD3_k127_343437_9	1380394.JADL01000001_gene2217	2.059e-66	233.0	COG0747@1|root,COG0747@2|Bacteria,1MU3P@1224|Proteobacteria,2TT4M@28211|Alphaproteobacteria,2JQRE@204441|Rhodospirillales	204441|Rhodospirillales	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
HKD3_k127_343437_6	469595.CSAG_01073	1.711e-95	332.0	COG1028@1|root,COG1028@2|Bacteria,1MWB6@1224|Proteobacteria,1RMZB@1236|Gammaproteobacteria,3WVSW@544|Citrobacter	1236|Gammaproteobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	kduD	-	1.1.1.127	ko:K00065	ko00040,map00040	-	R01542	RC00089	ko00000,ko00001,ko01000	-	-	-	adh_short_C2
HKD3_k127_343437_2	998088.B565_2111	8.812e-122	396.0	COG3717@1|root,COG3717@2|Bacteria,1MU9D@1224|Proteobacteria,1RPDB@1236|Gammaproteobacteria,1Y3EP@135624|Aeromonadales	135624|Aeromonadales	G	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate	kduI	-	5.3.1.17	ko:K01815	ko00040,map00040	-	R04383	RC00541	ko00000,ko00001,ko01000	-	-	-	KduI
HKD3_k127_343437_0	1268622.AVS7_03485	1.326e-154	504.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2VI4Q@28216|Betaproteobacteria,4A9SZ@80864|Comamonadaceae	28216|Betaproteobacteria	O	Belongs to the peptidase S1C family	mucD	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
HKD3_k127_343437_5	62928.azo3673	9.599e-107	373.0	COG0642@1|root,COG0642@2|Bacteria,1QTSX@1224|Proteobacteria,2W1JF@28216|Betaproteobacteria,2KW6A@206389|Rhodocyclales	206389|Rhodocyclales	T	His Kinase A (phosphoacceptor) domain	-	-	2.7.13.3	ko:K02484	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA
HKD3_k127_343437_7	1123368.AUIS01000019_gene1207	2.278e-91	306.0	COG0745@1|root,COG0745@2|Bacteria,1N0YI@1224|Proteobacteria,1RQQ3@1236|Gammaproteobacteria,2NCT4@225057|Acidithiobacillales	225057|Acidithiobacillales	K	Transcriptional regulatory protein, C terminal	-	-	-	ko:K02483	-	-	-	-	ko00000,ko02022	-	-	-	Response_reg,Trans_reg_C
HKD3_k127_343437_11	402777.KB235899_gene4852	6.756e-53	209.0	COG0229@1|root,COG0229@2|Bacteria,1G5S6@1117|Cyanobacteria,1HB1V@1150|Oscillatoriales	1117|Cyanobacteria	O	Belongs to the MsrB Met sulfoxide reductase family	msrB	-	1.8.4.12	ko:K07305	-	-	-	-	ko00000,ko01000	-	-	-	SelR
HKD3_k127_343437_8	1095769.CAHF01000010_gene1271	2.041e-85	307.0	COG2271@1|root,COG2271@2|Bacteria,1QU9E@1224|Proteobacteria,2WGJT@28216|Betaproteobacteria,473TE@75682|Oxalobacteraceae	28216|Betaproteobacteria	G	Major Facilitator Superfamily	fsr1	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
HKD3_k127_343437_4	1380394.JADL01000007_gene4512	9.191e-107	371.0	COG1028@1|root,COG1028@2|Bacteria,1MWJI@1224|Proteobacteria,2TRNJ@28211|Alphaproteobacteria,2JQV0@204441|Rhodospirillales	204441|Rhodospirillales	IQ	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short,adh_short_C2
HKD3_k127_343437_3	1003200.AXXA_26745	1.58e-108	363.0	COG0625@1|root,COG0625@2|Bacteria,1MUN3@1224|Proteobacteria,2VHCD@28216|Betaproteobacteria,3T2BC@506|Alcaligenaceae	28216|Betaproteobacteria	O	Belongs to the GST superfamily	-	-	2.5.1.18	ko:K00799,ko:K11209	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C,GST_N
HKD3_k127_343437_1	1265502.KB905948_gene1027	2.139e-129	421.0	COG0037@1|root,COG0037@2|Bacteria,1MW5Q@1224|Proteobacteria,2VHWH@28216|Betaproteobacteria,4AAVN@80864|Comamonadaceae	28216|Betaproteobacteria	J	Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine cysteine desulfurase (IscS) system	ttcA	-	-	ko:K14058	-	-	-	-	ko00000,ko03016	-	-	-	ATP_bind_3
HKD3_k127_343437_10	1163617.SCD_n02382	2.073e-61	224.0	COG1192@1|root,COG1192@2|Bacteria,1QBJX@1224|Proteobacteria,2VJNI@28216|Betaproteobacteria	28216|Betaproteobacteria	D	Cobyrinic acid ac-diamide synthase	-	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31,CbiA
HKD3_k127_343437_12	312153.Pnuc_1547	2.672e-50	186.0	COG0697@1|root,COG0697@2|Bacteria,1MZXM@1224|Proteobacteria,2VK90@28216|Betaproteobacteria,1K3YE@119060|Burkholderiaceae	28216|Betaproteobacteria	EG	EamA-like transporter family	-	-	-	ko:K15270	-	-	-	-	ko00000,ko02000	2.A.7.3.7	-	-	EamA
HKD3_k127_356944_9	1122604.JONR01000005_gene960	1.786e-79	279.0	COG0845@1|root,COG0845@2|Bacteria,1MX0G@1224|Proteobacteria,1RN0S@1236|Gammaproteobacteria,1X433@135614|Xanthomonadales	135614|Xanthomonadales	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	HlyD_D23
HKD3_k127_356944_2	522306.CAP2UW1_3612	3.378e-141	461.0	COG0683@1|root,COG0683@2|Bacteria,1MWJ1@1224|Proteobacteria,2VH55@28216|Betaproteobacteria,1KQBE@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	E	Receptor family ligand binding region	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
HKD3_k127_356944_5	1454004.AW11_00402	2.28e-120	395.0	COG0559@1|root,COG0559@2|Bacteria,1MU25@1224|Proteobacteria,2VJAS@28216|Betaproteobacteria,1KQHA@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	U	Branched-chain amino acid transport system / permease component	livH	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HKD3_k127_356944_3	1454004.AW11_00403	2.457e-139	470.0	COG4177@1|root,COG4177@2|Bacteria,1MV66@1224|Proteobacteria,2VH43@28216|Betaproteobacteria,1KQDQ@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	U	Branched-chain amino acid transport system / permease component	livM	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HKD3_k127_356944_7	94624.Bpet2651	1.266e-103	361.0	COG0411@1|root,COG0411@2|Bacteria,1MUTY@1224|Proteobacteria,2VJM6@28216|Betaproteobacteria,3T22A@506|Alcaligenaceae	28216|Betaproteobacteria	E	ABC-type branched-chain amino acid transport systems ATPase component	livG	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
HKD3_k127_356944_6	94624.Bpet2650	1.092e-107	353.0	COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,2VHYN@28216|Betaproteobacteria,3T3A0@506|Alcaligenaceae	28216|Betaproteobacteria	E	ABC-type branched-chain amino acid transport systems ATPase component	livF	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
HKD3_k127_356944_14	748247.AZKH_0586	1.822e-09	69.0	COG5473@1|root,COG5473@2|Bacteria,1N9UJ@1224|Proteobacteria,2VRZ3@28216|Betaproteobacteria,2KX03@206389|Rhodocyclales	206389|Rhodocyclales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_356944_13	1157708.KB907457_gene2818	2.208e-18	94.0	COG1254@1|root,COG1254@2|Bacteria,1N6NU@1224|Proteobacteria,2VVRU@28216|Betaproteobacteria,4AFGX@80864|Comamonadaceae	28216|Betaproteobacteria	C	Belongs to the acylphosphatase family	acyP	-	3.6.1.7	ko:K01512	ko00620,ko00627,ko01120,map00620,map00627,map01120	-	R00317,R01421,R01515	RC00043	ko00000,ko00001,ko01000	-	-	-	Acylphosphatase
HKD3_k127_356944_10	360910.BAV2428	4.872e-58	209.0	COG0494@1|root,COG0494@2|Bacteria,1RCX7@1224|Proteobacteria,2VRU5@28216|Betaproteobacteria,3T3UU@506|Alcaligenaceae	28216|Betaproteobacteria	L	NUDIX domain	nudF	-	3.6.1.13	ko:K01515	ko00230,map00230	-	R01054	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX
HKD3_k127_356944_1	1123487.KB892835_gene3563	2.793e-141	456.0	COG0408@1|root,COG0408@2|Bacteria,1MWMF@1224|Proteobacteria,2VIN4@28216|Betaproteobacteria,2KV9H@206389|Rhodocyclales	206389|Rhodocyclales	H	Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX	hemF	GO:0003674,GO:0005488,GO:0005515,GO:0042802,GO:0042803,GO:0046983	1.3.3.3	ko:K00228	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03220	RC00884	ko00000,ko00001,ko00002,ko01000	-	-	-	Coprogen_oxidas
HKD3_k127_356944_8	1123073.KB899245_gene15	2.683e-96	321.0	COG0035@1|root,COG0035@2|Bacteria,1MV4N@1224|Proteobacteria,1RPBG@1236|Gammaproteobacteria,1X45T@135614|Xanthomonadales	135614|Xanthomonadales	F	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate	upp	GO:0003674,GO:0003824,GO:0004849,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006213,GO:0006220,GO:0006221,GO:0006222,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008655,GO:0009058,GO:0009112,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009173,GO:0009174,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0018130,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0043094,GO:0043097,GO:0043174,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046049,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.4.2.9	ko:K00761	ko00240,ko01100,map00240,map01100	-	R00966	RC00063	ko00000,ko00001,ko01000	-	-	-	UPRTase
HKD3_k127_356944_12	765910.MARPU_02025	4.805e-22	111.0	COG1073@1|root,COG1073@2|Bacteria,1RCSJ@1224|Proteobacteria,1S2PJ@1236|Gammaproteobacteria,1WY3V@135613|Chromatiales	135613|Chromatiales	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_356944_0	292415.Tbd_2459	1.558e-193	613.0	COG0151@1|root,COG0151@2|Bacteria,1MUAH@1224|Proteobacteria,2VH9J@28216|Betaproteobacteria,1KS4T@119069|Hydrogenophilales	119069|Hydrogenophilales	F	Phosphoribosylglycinamide synthetase, C domain	-	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	GARS_A,GARS_C,GARS_N
HKD3_k127_356944_11	1120999.JONM01000026_gene1526	3.711e-39	153.0	2C256@1|root,2Z7SY@2|Bacteria,1Q75P@1224|Proteobacteria,2VUK3@28216|Betaproteobacteria,2KS1F@206351|Neisseriales	206351|Neisseriales	M	Transfers a palmitate residue from the sn-1 position of a phospholipid to the N-linked hydroxymyristate on the proximal unit of lipid A or its precursors	-	-	2.3.1.251	ko:K12973	ko01503,ko05133,map01503,map05133	M00724	R11223	RC00037,RC00041	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	PagP
HKD3_k127_356944_4	323848.Nmul_A0133	6.84e-135	434.0	COG0138@1|root,COG0138@2|Bacteria,1MUDQ@1224|Proteobacteria,2VJPX@28216|Betaproteobacteria,372QA@32003|Nitrosomonadales	28216|Betaproteobacteria	F	Bifunctional purine biosynthesis protein PurH	purH	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AICARFT_IMPCHas,MGS
HKD3_k127_3640430_1	1442599.JAAN01000010_gene320	1.091e-105	354.0	COG1233@1|root,COG1233@2|Bacteria,1MV2R@1224|Proteobacteria,1RSGI@1236|Gammaproteobacteria,1X5MS@135614|Xanthomonadales	135614|Xanthomonadales	Q	Oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
HKD3_k127_3640430_0	1000565.METUNv1_02776	4.47e-111	365.0	COG0623@1|root,COG0623@2|Bacteria,1MV05@1224|Proteobacteria,2VIHE@28216|Betaproteobacteria,2KV9V@206389|Rhodocyclales	206389|Rhodocyclales	I	Enoyl- acyl-carrier-protein reductase NADH	fabI	-	1.3.1.10,1.3.1.9	ko:K00208	ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212	M00083,M00572	R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671	RC00052,RC00076,RC00120	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HKD3_k127_3640430_2	313594.PI23P_07510	5.983e-05	53.0	COG2032@1|root,COG2032@2|Bacteria,4NM88@976|Bacteroidetes,1I17T@117743|Flavobacteriia,3VWN0@52959|Polaribacter	976|Bacteroidetes	P	Copper/zinc superoxide dismutase (SODC)	sodC	-	1.15.1.1	ko:K04565	ko04146,ko04213,ko05014,ko05016,ko05020,map04146,map04213,map05014,map05016,map05020	-	-	-	ko00000,ko00001,ko01000	-	-	-	Sod_Cu
HKD3_k127_3677793_9	257310.BB3434	8.722e-53	186.0	COG3460@1|root,COG3460@2|Bacteria,1RHM5@1224|Proteobacteria,2VST3@28216|Betaproteobacteria,3T7MV@506|Alcaligenaceae	28216|Betaproteobacteria	Q	Phenylacetic acid degradation B	paaB	-	-	ko:K02610	ko00360,ko01120,map00360,map01120	-	R09838	RC02690	ko00000,ko00001	-	-	-	PaaB
HKD3_k127_3677793_6	1217718.ALOU01000005_gene1537	1.452e-101	338.0	COG3396@1|root,COG3396@2|Bacteria,1MVYQ@1224|Proteobacteria,2VJ03@28216|Betaproteobacteria	28216|Betaproteobacteria	S	phenylacetic acid	paaC	-	1.14.13.149	ko:K02611	ko00360,ko01120,map00360,map01120	-	R09838	RC02690	ko00000,ko00001,ko01000	-	-	-	PaaA_PaaC
HKD3_k127_3677793_7	1122603.ATVI01000011_gene1996	1.66e-61	220.0	COG2151@1|root,COG2151@2|Bacteria,1RF3S@1224|Proteobacteria,1S4FY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	phenylacetate-CoA oxygenase, PaaJ subunit	paaD	GO:0006082,GO:0006725,GO:0006805,GO:0008150,GO:0008152,GO:0009056,GO:0009404,GO:0009407,GO:0009410,GO:0009636,GO:0009850,GO:0009852,GO:0009987,GO:0010124,GO:0010817,GO:0016054,GO:0019439,GO:0019748,GO:0019752,GO:0032787,GO:0042178,GO:0042221,GO:0042445,GO:0042447,GO:0042537,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0050896,GO:0051716,GO:0065007,GO:0065008,GO:0070887,GO:0071466,GO:0071704,GO:0072329,GO:0098754,GO:1901360,GO:1901361,GO:1901575	-	ko:K02612	ko00360,ko01120,map00360,map01120	-	R09838	RC02690	ko00000,ko00001	-	-	iECSE_1348.ECSE_1476	FeS_assembly_P
HKD3_k127_3677793_3	1349767.GJA_640	3.49e-142	471.0	COG1018@1|root,COG1018@2|Bacteria,1MY2Q@1224|Proteobacteria,2VKK1@28216|Betaproteobacteria,4736I@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	Oxidoreductase FAD-binding domain	paaE	-	-	ko:K02613	ko00360,ko01120,map00360,map01120	-	R09838	RC02690	ko00000,ko00001	-	-	-	FAD_binding_6,Fer2,NAD_binding_1
HKD3_k127_3677793_0	264198.Reut_B3740	4.173e-262	819.0	COG1012@1|root,COG1012@2|Bacteria,1MY4N@1224|Proteobacteria,2VH9F@28216|Betaproteobacteria,1K0D7@119060|Burkholderiaceae	28216|Betaproteobacteria	C	phenylacetic acid degradation protein paaN	paaN	-	-	-	-	-	-	-	-	-	-	-	Aldedh
HKD3_k127_3677793_5	1349767.GJA_641	2.128e-118	385.0	COG1024@1|root,COG1024@2|Bacteria,1MVQN@1224|Proteobacteria,2VHE9@28216|Betaproteobacteria,472BK@75682|Oxalobacteraceae	28216|Betaproteobacteria	I	enoyl-CoA hydratase	paaG	-	5.3.3.18	ko:K15866	ko00360,ko01120,map00360,map01120	-	R09837,R09839	RC00004,RC00326,RC02689,RC03003	ko00000,ko00001,ko01000	-	-	-	ECH_1
HKD3_k127_3677793_2	883126.HMPREF9710_01411	1.98e-163	544.0	COG1250@1|root,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,2VK75@28216|Betaproteobacteria,472K8@75682|Oxalobacteraceae	28216|Betaproteobacteria	I	PFAM 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain, 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain	paaH	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
HKD3_k127_3677793_8	1392838.AWNM01000004_gene1862	2.143e-55	198.0	COG2050@1|root,COG2050@2|Bacteria,1RH35@1224|Proteobacteria,2VRC2@28216|Betaproteobacteria,3T3V9@506|Alcaligenaceae	28216|Betaproteobacteria	Q	Phenylacetic acid degradation protein	paaI	GO:0003674,GO:0003824,GO:0016289,GO:0016787,GO:0016788,GO:0016790	-	ko:K02614	ko00360,map00360	-	R09840	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	4HBT
HKD3_k127_3677793_1	977880.RALTA_B1603	1.146e-210	662.0	COG1541@1|root,COG1541@2|Bacteria,1MV1W@1224|Proteobacteria,2VI46@28216|Betaproteobacteria,1K3IM@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)	paaK	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C_2
HKD3_k127_3677793_4	1144275.COCOR_02790	3.247e-121	407.0	COG0436@1|root,COG0436@2|Bacteria,1QE0D@1224|Proteobacteria	1224|Proteobacteria	E	aminotransferase	-	-	4.1.1.12	ko:K09758	ko00250,ko00270,ko01100,ko01230,map00250,map00270,map01100,map01230	-	R00397,R00863	RC00282,RC00399,RC00400	ko00000,ko00001,ko01000	-	-	-	Aminotran_1_2
HKD3_k127_3685528_0	1095769.CAHF01000013_gene3363	0.0	1338.0	COG0495@1|root,COG0495@2|Bacteria,1MV47@1224|Proteobacteria,2VH2J@28216|Betaproteobacteria,472M6@75682|Oxalobacteraceae	28216|Betaproteobacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
HKD3_k127_3685528_3	1288494.EBAPG3_5100	3.425e-30	126.0	COG2980@1|root,COG2980@2|Bacteria,1N13K@1224|Proteobacteria,2VU54@28216|Betaproteobacteria,3738A@32003|Nitrosomonadales	28216|Betaproteobacteria	M	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane	lptE	-	-	ko:K03643	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	LptE
HKD3_k127_3685528_1	557598.LHK_00117	1.48e-92	315.0	COG1466@1|root,COG1466@2|Bacteria,1MWYT@1224|Proteobacteria,2VIKX@28216|Betaproteobacteria,2KQ18@206351|Neisseriales	206351|Neisseriales	L	DNA polymerase III, delta' subunit	holA	-	2.7.7.7	ko:K02340	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delt_C,DNA_pol3_delta
HKD3_k127_3685528_2	1095769.CAHF01000022_gene72	2.203e-32	137.0	COG0589@1|root,COG0589@2|Bacteria,1NDDA@1224|Proteobacteria,2VWAD@28216|Betaproteobacteria,474HT@75682|Oxalobacteraceae	28216|Betaproteobacteria	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD3_k127_3691830_2	395494.Galf_2490	1.718e-08	57.0	COG0845@1|root,COG0845@2|Bacteria,1MV1R@1224|Proteobacteria,2VHJC@28216|Betaproteobacteria,44WE6@713636|Nitrosomonadales	28216|Betaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_D23
HKD3_k127_3691830_0	580332.Slit_1134	4.371e-188	597.0	COG0577@1|root,COG0577@2|Bacteria,1MVSU@1224|Proteobacteria,2VKTK@28216|Betaproteobacteria,44W6X@713636|Nitrosomonadales	28216|Betaproteobacteria	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HKD3_k127_3691830_1	1123393.KB891331_gene2990	1.49e-30	123.0	COG1136@1|root,COG1136@2|Bacteria,1MXVW@1224|Proteobacteria,2VI95@28216|Betaproteobacteria,1KSHZ@119069|Hydrogenophilales	119069|Hydrogenophilales	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD3_k127_3725117_19	224911.27352037	2.968e-16	83.0	COG4757@1|root,COG4757@2|Bacteria,1Q1V6@1224|Proteobacteria,2U1QB@28211|Alphaproteobacteria,3JT7Z@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6,Hydrolase_4
HKD3_k127_3725117_9	159087.Daro_1211	3.964e-117	381.0	COG2086@1|root,COG2086@2|Bacteria,1MVH6@1224|Proteobacteria,2VHXJ@28216|Betaproteobacteria,2KUTX@206389|Rhodocyclales	206389|Rhodocyclales	C	Electron transfer flavoprotein	-	-	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
HKD3_k127_3725117_8	1121004.ATVC01000006_gene1308	1.072e-123	404.0	COG2025@1|root,COG2025@2|Bacteria,1MUFI@1224|Proteobacteria,2VI6W@28216|Betaproteobacteria,2KQB3@206351|Neisseriales	206351|Neisseriales	C	electron transfer flavoprotein	etfA	-	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	-	ETF,ETF_alpha
HKD3_k127_3725117_1	62928.azo1702	8.353e-247	775.0	COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,2VGZD@28216|Betaproteobacteria,2KUFZ@206389|Rhodocyclales	206389|Rhodocyclales	C	COG1960 Acyl-CoA dehydrogenases	-	-	-	ko:K20035	ko00920,map00920	-	R11130	RC03363	ko00000,ko00001,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N
HKD3_k127_3725117_6	1054213.HMPREF9946_03665	2.039e-127	419.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2TQMJ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system	fbpC	-	3.6.3.30	ko:K02010	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.10	-	-	ABC_tran,TOBE_2
HKD3_k127_3725117_0	331869.BAL199_21694	6.242e-264	832.0	COG1178@1|root,COG1178@2|Bacteria,1MXZZ@1224|Proteobacteria,2TT7F@28211|Alphaproteobacteria,4BRC3@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	fbpB	-	-	ko:K02011	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	BPD_transp_1
HKD3_k127_3725117_10	420324.KI912045_gene4141	4.179e-103	374.0	COG1840@1|root,COG1840@2|Bacteria,1MXZ8@1224|Proteobacteria,2TT9W@28211|Alphaproteobacteria,1JWBY@119045|Methylobacteriaceae	28211|Alphaproteobacteria	P	Bacterial extracellular solute-binding protein	afuA1	-	-	ko:K02012,ko:K11081	ko02010,map02010	M00190,M00302	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10,3.A.1.11.5	-	-	SBP_bac_6
HKD3_k127_3725117_15	1194972.MVAC_10437	1.174e-53	211.0	2AHT8@1|root,3185S@2|Bacteria,2IMSB@201174|Actinobacteria,239JV@1762|Mycobacteriaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_3725117_3	1194972.MVAC_10442	1.466e-195	627.0	COG1226@1|root,COG1226@2|Bacteria,2HX5T@201174|Actinobacteria,237N6@1762|Mycobacteriaceae	201174|Actinobacteria	P	TrkA-N domain	-	-	-	-	-	-	-	-	-	-	-	-	TrkA_N
HKD3_k127_3725117_7	335543.Sfum_0489	1.615e-124	421.0	COG1940@1|root,COG1940@2|Bacteria,1MU94@1224|Proteobacteria,42RF4@68525|delta/epsilon subdivisions,2WM43@28221|Deltaproteobacteria	28221|Deltaproteobacteria	GK	PFAM ROK family protein	mak	-	2.7.1.2,2.7.1.4	ko:K00845,ko:K00847	ko00010,ko00051,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00051,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R00760,R00867,R01600,R01786,R03920	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
HKD3_k127_3725117_14	864051.BurJ1DRAFT_0517	1.551e-56	210.0	COG1403@1|root,COG1403@2|Bacteria,1MWEQ@1224|Proteobacteria,2VKQH@28216|Betaproteobacteria,1KIUW@119065|unclassified Burkholderiales	28216|Betaproteobacteria	L	HNH nucleases	-	-	-	-	-	-	-	-	-	-	-	-	HNH_5
HKD3_k127_3725117_13	391038.Bphy_5215	2.417e-62	220.0	COG0317@1|root,COG0317@2|Bacteria,1RGUA@1224|Proteobacteria,2VQUA@28216|Betaproteobacteria,1K6XY@119060|Burkholderiaceae	28216|Betaproteobacteria	KT	SMART metal-dependent phosphohydrolase, HD region	-	-	2.7.6.5,3.1.7.2	ko:K01139	ko00230,map00230	-	R00336,R00429	RC00002,RC00078	ko00000,ko00001,ko01000,ko03009	-	-	-	HD_4
HKD3_k127_3725117_17	1123368.AUIS01000029_gene1290	4.854e-45	169.0	COG1499@1|root,COG1499@2|Bacteria,1RD49@1224|Proteobacteria,1S4E9@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	ribosomal large subunit export from nucleus	-	-	-	-	-	-	-	-	-	-	-	-	NMD3
HKD3_k127_3725117_12	1172179.AUKV01000009_gene4529	3.373e-72	250.0	COG1926@1|root,COG1926@2|Bacteria,2GJUU@201174|Actinobacteria	201174|Actinobacteria	Q	phosphoribosyltransferase	-	-	-	ko:K07100	-	-	-	-	ko00000	-	-	-	DLH,Pribosyltran
HKD3_k127_3725117_4	1265502.KB905961_gene349	7.018e-148	481.0	COG0389@1|root,COG0389@2|Bacteria,1MUUH@1224|Proteobacteria,2VJNS@28216|Betaproteobacteria,4A9Z0@80864|Comamonadaceae	28216|Betaproteobacteria	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	dinB	GO:0000731,GO:0003674,GO:0003824,GO:0003887,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0006139,GO:0006259,GO:0006281,GO:0006301,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016604,GO:0016607,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019985,GO:0031974,GO:0031981,GO:0032991,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0035770,GO:0036464,GO:0042276,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044451,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0070013,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576,GO:1990904	2.7.7.7	ko:K02346,ko:K03502	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C,IMS_HHH
HKD3_k127_3725117_11	243160.BMA0055	1.049e-89	305.0	COG0583@1|root,COG0583@2|Bacteria,1MWY0@1224|Proteobacteria,2VM7N@28216|Betaproteobacteria,1KGR4@119060|Burkholderiaceae	28216|Betaproteobacteria	K	LysR substrate binding domain	-	-	-	ko:K03566	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_1,LysR_substrate
HKD3_k127_3725117_18	748280.NH8B_2936	7.239e-32	135.0	COG0653@1|root,COG3318@1|root,COG0653@2|Bacteria,COG3318@2|Bacteria,1R4KR@1224|Proteobacteria,2VTNW@28216|Betaproteobacteria,2KRBX@206351|Neisseriales	206351|Neisseriales	U	Psort location Cytoplasmic, score 8.96	-	-	-	ko:K07039	-	-	-	-	ko00000	-	-	-	SEC-C,UPF0149
HKD3_k127_3725117_16	1238182.C882_2183	7.275e-50	196.0	COG2391@1|root,COG2391@2|Bacteria,1NADV@1224|Proteobacteria,2UGU0@28211|Alphaproteobacteria,2JY34@204441|Rhodospirillales	204441|Rhodospirillales	S	Sulphur transport	-	-	-	ko:K07112	-	-	-	-	ko00000	-	-	-	Sulf_transp
HKD3_k127_3725117_5	257310.BB0405	1.561e-138	465.0	COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,2VP9T@28216|Betaproteobacteria,3T5E3@506|Alcaligenaceae	28216|Betaproteobacteria	J	Belongs to the amidase family	gatA3	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
HKD3_k127_3725117_2	887898.HMPREF0551_2591	1.226e-205	673.0	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,2VH4J@28216|Betaproteobacteria,1K219@119060|Burkholderiaceae	28216|Betaproteobacteria	S	abc transporter	uup	-	-	ko:K15738	-	-	-	-	ko00000,ko02000	3.A.1.120.6	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
HKD3_k127_3725117_20	1237149.C900_01850	6.504e-12	78.0	COG4409@1|root,COG4409@2|Bacteria,4NJCZ@976|Bacteroidetes	976|Bacteroidetes	G	exo-alpha-(2->6)-sialidase activity	-	-	-	-	-	-	-	-	-	-	-	-	BNR_2
HKD3_k127_3739826_28	1348657.M622_12105	6.361e-06	48.0	COG1765@1|root,COG1765@2|Bacteria,1RCZW@1224|Proteobacteria,2VR62@28216|Betaproteobacteria,2KWBK@206389|Rhodocyclales	206389|Rhodocyclales	O	redox protein, regulator of disulfide bond formation	-	-	-	ko:K07397	-	-	-	-	ko00000	-	-	-	OsmC
HKD3_k127_3739826_10	693986.MOC_5191	1.501e-124	419.0	COG2084@1|root,COG2084@2|Bacteria,1MUGU@1224|Proteobacteria,2TT50@28211|Alphaproteobacteria,1JTBT@119045|Methylobacteriaceae	28211|Alphaproteobacteria	I	NADP oxidoreductase coenzyme F420-dependent	MA20_25935	-	1.1.1.31,1.1.1.60	ko:K00020,ko:K00042	ko00280,ko00630,ko01100,map00280,map00630,map01100	-	R01745,R01747,R05066	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
HKD3_k127_3739826_2	1123354.AUDR01000016_gene1294	3.177e-208	666.0	COG0165@1|root,COG0165@2|Bacteria,1MUTU@1224|Proteobacteria,2VH47@28216|Betaproteobacteria,1KRB4@119069|Hydrogenophilales	119069|Hydrogenophilales	E	Argininosuccinate lyase C-terminal	argH	-	4.3.2.1	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01086	RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ASL_C2,Lyase_1
HKD3_k127_3739826_12	1163617.SCD_n02801	4.783e-97	333.0	COG2972@1|root,COG2972@2|Bacteria,1MXVQ@1224|Proteobacteria,2VH9S@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Histidine kinase	algZ	-	2.7.13.3	ko:K08082	ko02020,map02020	M00493	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	His_kinase
HKD3_k127_3739826_14	1163617.SCD_n02800	1.384e-85	297.0	COG3279@1|root,COG3279@2|Bacteria,1MUE8@1224|Proteobacteria,2WEFP@28216|Betaproteobacteria	28216|Betaproteobacteria	KT	response regulator	algR	-	-	ko:K08083	ko02020,map02020	M00493	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	LytTR,Response_reg
HKD3_k127_3739826_7	748247.AZKH_3752	2.159e-129	420.0	COG0524@1|root,COG0524@2|Bacteria,1PDQE@1224|Proteobacteria,2VHMF@28216|Betaproteobacteria,2KUNE@206389|Rhodocyclales	206389|Rhodocyclales	G	COG0524 Sugar kinases, ribokinase family	pfkB	-	2.7.1.20	ko:K00856	ko00230,ko01100,map00230,map01100	-	R00185	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
HKD3_k127_3739826_18	1163617.SCD_n02773	4.49e-52	200.0	COG0204@1|root,COG0204@2|Bacteria,1N2DG@1224|Proteobacteria,2VSJD@28216|Betaproteobacteria	28216|Betaproteobacteria	I	Acyltransferase	plsC	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
HKD3_k127_3739826_13	76114.ebA1627	4.423e-92	313.0	COG0639@1|root,COG0639@2|Bacteria,1MV10@1224|Proteobacteria,2VHV6@28216|Betaproteobacteria,2KUKD@206389|Rhodocyclales	206389|Rhodocyclales	T	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP	apaH	-	3.6.1.41	ko:K01525	ko00230,map00230	-	R00125	RC00002	ko00000,ko00001,ko01000	-	-	-	Metallophos
HKD3_k127_3739826_1	292415.Tbd_0166	1.399e-230	733.0	COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,2VJFM@28216|Betaproteobacteria,1KRAU@119069|Hydrogenophilales	119069|Hydrogenophilales	L	it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction	rep	-	3.6.4.12	ko:K03656	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
HKD3_k127_3739826_17	1095769.CAHF01000005_gene1570	2.482e-63	231.0	COG3245@1|root,COG3245@2|Bacteria,1MZBZ@1224|Proteobacteria,2VMBB@28216|Betaproteobacteria,476ER@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
HKD3_k127_3739826_29	1150469.RSPPHO_02781	7.611e-06	51.0	COG2165@1|root,COG2165@2|Bacteria,1PJ5F@1224|Proteobacteria,2VC7I@28211|Alphaproteobacteria,2JY2W@204441|Rhodospirillales	204441|Rhodospirillales	NU	general secretion pathway protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_3739826_30	1245471.PCA10_07590	0.0003415	49.0	2E46A@1|root,32Z28@2|Bacteria,1N6V5@1224|Proteobacteria,1TC48@1236|Gammaproteobacteria,1YJTM@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_3739826_26	266264.Rmet_3472	3.446e-23	104.0	2E6EG@1|root,3311Y@2|Bacteria,1NE8A@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Gly-zipper_Omp,Gly-zipper_YMGG
HKD3_k127_3739826_23	1121127.JAFA01000043_gene4189	3.83e-36	144.0	2E9FY@1|root,333P7@2|Bacteria,1N8S6@1224|Proteobacteria,2VWAN@28216|Betaproteobacteria,1K7R1@119060|Burkholderiaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_3739826_0	1458357.BG58_05605	0.0	1048.0	COG3243@1|root,COG3243@2|Bacteria,1MUNE@1224|Proteobacteria,2VJZW@28216|Betaproteobacteria,1K3Z3@119060|Burkholderiaceae	28216|Betaproteobacteria	I	Protein of unknown function (DUF3141)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3141
HKD3_k127_3739826_3	1454004.AW11_03031	6.627e-159	505.0	COG0280@1|root,COG0280@2|Bacteria,1QTXP@1224|Proteobacteria,2VJ4B@28216|Betaproteobacteria	28216|Betaproteobacteria	C	phosphate	pta	-	2.3.1.8	ko:K00625	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00230,R00921	RC00004,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000	-	-	-	PTA_PTB
HKD3_k127_3739826_8	706587.Desti_5204	3.076e-129	439.0	COG0623@1|root,COG0623@2|Bacteria,1MV05@1224|Proteobacteria,42MA4@68525|delta/epsilon subdivisions,2WIPU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	Enoyl- acyl-carrier-protein reductase NADH	fabI	-	1.3.1.10,1.3.1.9	ko:K00208	ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212	M00083,M00572	R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671	RC00052,RC00076,RC00120	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HKD3_k127_3739826_20	335543.Sfum_1474	3.939e-46	173.0	COG1670@1|root,COG1670@2|Bacteria	2|Bacteria	J	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins	mshD	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0008080,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0017076,GO:0030551,GO:0030552,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363	2.3.1.189	ko:K09181,ko:K15520	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_1,Acetyltransf_3,cNMP_binding
HKD3_k127_3739826_25	65093.PCC7418_2879	4.375e-24	112.0	COG0385@1|root,COG0385@2|Bacteria,1G6ZW@1117|Cyanobacteria	1117|Cyanobacteria	S	Na( )-dependent transporter	-	-	-	-	-	-	-	-	-	-	-	-	SBF
HKD3_k127_3739826_5	1169143.KB911034_gene988	3.661e-132	448.0	COG4325@1|root,COG4325@2|Bacteria,1MXTM@1224|Proteobacteria,2VKHS@28216|Betaproteobacteria,1K3KH@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Predicted membrane protein (DUF2254)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2254
HKD3_k127_3739826_19	1419583.V466_02345	6.6e-47	193.0	COG1814@1|root,COG1814@2|Bacteria,1R469@1224|Proteobacteria	1224|Proteobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	VIT1
HKD3_k127_3739826_22	381666.H16_A2494	3.074e-40	166.0	2E3FB@1|root,32YE4@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_3739826_4	522306.CAP2UW1_1272	1.043e-132	431.0	COG4313@1|root,COG4313@2|Bacteria,1PRCN@1224|Proteobacteria,2VQHT@28216|Betaproteobacteria,1KQK1@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	C	Protein involved in meta-pathway of phenol degradation	-	-	-	-	-	-	-	-	-	-	-	-	Phenol_MetA_deg
HKD3_k127_3739826_27	926569.ANT_17920	1.441e-07	60.0	COG2146@1|root,COG2146@2|Bacteria,2G7AG@200795|Chloroflexi	200795|Chloroflexi	P	PFAM Rieske 2Fe-2S domain protein	-	-	1.7.1.15	ko:K00363,ko:K05710	ko00360,ko00910,ko01120,ko01220,map00360,map00910,map01120,map01220	M00530,M00545	R00787,R06782,R06783	RC00098,RC00176	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	Rieske
HKD3_k127_3739826_15	420324.KI912013_gene9358	4.477e-74	263.0	COG2207@1|root,COG2207@2|Bacteria,1MX23@1224|Proteobacteria,2TT6H@28211|Alphaproteobacteria,1JRS3@119045|Methylobacteriaceae	28211|Alphaproteobacteria	K	PFAM helix-turn-helix- domain containing protein AraC type	-	-	-	-	-	-	-	-	-	-	-	-	Arabinose_bd,HTH_18
HKD3_k127_3739826_21	1396141.BATP01000002_gene4799	1.267e-41	162.0	2DHJ6@1|root,3000S@2|Bacteria,46VCS@74201|Verrucomicrobia,2IVUB@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Protein of unknown function (DUF3302)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3302
HKD3_k127_3739826_11	1458357.BG58_09875	9.113e-118	400.0	COG1566@1|root,COG1566@2|Bacteria,1NAMI@1224|Proteobacteria,2VZSW@28216|Betaproteobacteria,1K5Z2@119060|Burkholderiaceae	28216|Betaproteobacteria	V	Biotin-lipoyl like	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2
HKD3_k127_3739826_9	1458357.BG58_09870	5.979e-128	435.0	COG1538@1|root,COG1538@2|Bacteria,1REC6@1224|Proteobacteria,2VZ9S@28216|Betaproteobacteria,1KBKV@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
HKD3_k127_3739826_6	1232410.KI421426_gene1482	1.128e-131	426.0	COG2326@1|root,COG2326@2|Bacteria,1MVE2@1224|Proteobacteria,42M26@68525|delta/epsilon subdivisions,2WKQV@28221|Deltaproteobacteria,43V5R@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Polyphosphate kinase 2 (PPK2)	-	-	2.7.4.1	ko:K22468	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PPK2
HKD3_k127_3739826_24	1101195.Meth11DRAFT_1975	1.573e-35	138.0	2CKE6@1|root,32ZEV@2|Bacteria,1NBRM@1224|Proteobacteria,2VX50@28216|Betaproteobacteria,2KP0E@206350|Nitrosomonadales	206350|Nitrosomonadales	S	Family of unknown function (DUF5329)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5329
HKD3_k127_3739826_16	1095769.CAHF01000023_gene602	4.177e-71	249.0	COG1502@1|root,COG1502@2|Bacteria,1MUDJ@1224|Proteobacteria,2VHSI@28216|Betaproteobacteria,472YU@75682|Oxalobacteraceae	28216|Betaproteobacteria	I	Phospholipase D. Active site motifs.	-	-	-	ko:K06132	ko00564,ko01100,map00564,map01100	-	R11062	RC00017	ko00000,ko00001,ko01000	-	-	-	PLDc_2
HKD3_k127_3780575_11	543728.Vapar_3325	2.899e-92	307.0	COG0169@1|root,COG0169@2|Bacteria,1MVW5@1224|Proteobacteria,2VJU3@28216|Betaproteobacteria,4A9XV@80864|Comamonadaceae	28216|Betaproteobacteria	E	Shikimate dehydrogenase substrate binding domain protein	-	-	1.1.1.25	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413	RC00206	ko00000,ko00001,ko00002,ko01000	-	-	-	Shikimate_dh_N,ThiF
HKD3_k127_3780575_0	395495.Lcho_3686	9.077e-162	519.0	COG0683@1|root,COG0683@2|Bacteria,1MX94@1224|Proteobacteria,2VHQ4@28216|Betaproteobacteria	28216|Betaproteobacteria	E	COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
HKD3_k127_3780575_4	114615.BRADO2346	2.567e-115	377.0	COG0169@1|root,COG0169@2|Bacteria,1MVH4@1224|Proteobacteria,2TS99@28211|Alphaproteobacteria,3JUXR@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)	aroE	-	1.1.1.25	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413	RC00206	ko00000,ko00001,ko00002,ko01000	-	-	-	Shikimate_DH,Shikimate_dh_N
HKD3_k127_3780575_16	1267535.KB906767_gene2349	1.793e-30	128.0	COG3193@1|root,COG3193@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K11477	-	-	-	-	ko00000	-	-	-	Haem_degrading
HKD3_k127_3780575_3	1458275.AZ34_08390	2.431e-117	385.0	COG0559@1|root,COG0559@2|Bacteria,1MU25@1224|Proteobacteria,2VIDW@28216|Betaproteobacteria,4ABK5@80864|Comamonadaceae	28216|Betaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HKD3_k127_3780575_7	1458275.AZ34_08395	2.18e-103	350.0	COG4177@1|root,COG4177@2|Bacteria,1MV66@1224|Proteobacteria,2VJN3@28216|Betaproteobacteria,4AC7N@80864|Comamonadaceae	28216|Betaproteobacteria	P	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HKD3_k127_3780575_9	395495.Lcho_3689	3.248e-97	340.0	COG0411@1|root,COG0411@2|Bacteria,1MUTY@1224|Proteobacteria,2VMEE@28216|Betaproteobacteria	28216|Betaproteobacteria	E	ABC-type branched-chain amino acid transport systems ATPase component	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
HKD3_k127_3780575_12	887062.HGR_01237	2.213e-91	308.0	COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,2VMTW@28216|Betaproteobacteria,4AD7V@80864|Comamonadaceae	28216|Betaproteobacteria	E	amino acid	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
HKD3_k127_3780575_2	365044.Pnap_1650	1.159e-128	435.0	COG0683@1|root,COG0683@2|Bacteria,1N3V5@1224|Proteobacteria,2VKRP@28216|Betaproteobacteria,4AAXR@80864|Comamonadaceae	28216|Betaproteobacteria	E	Amino acid amide ABC transporter substrate-binding protein, HAAT family	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
HKD3_k127_3780575_5	365044.Pnap_1550	7.862e-109	361.0	COG0583@1|root,COG0583@2|Bacteria,1N663@1224|Proteobacteria,2VIKU@28216|Betaproteobacteria,4ADKQ@80864|Comamonadaceae	28216|Betaproteobacteria	K	Transcriptional regulator, LysR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HKD3_k127_3780575_1	488538.SAR116_0930	2.226e-132	433.0	COG0683@1|root,COG0683@2|Bacteria	2|Bacteria	E	ABC-type branched-chain amino acid transport systems, periplasmic component	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
HKD3_k127_3780575_8	488538.SAR116_0931	1.901e-100	346.0	COG4177@1|root,COG4177@2|Bacteria,1MV66@1224|Proteobacteria,2TSJQ@28211|Alphaproteobacteria,4BQP2@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	P	Branched-chain amino acid transport system / permease component	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HKD3_k127_3780575_10	488538.SAR116_0932	2.919e-95	319.0	COG0411@1|root,COG0411@2|Bacteria,1MUTY@1224|Proteobacteria,2TQK1@28211|Alphaproteobacteria,4BQ82@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	E	Branched-chain amino acid ATP-binding cassette transporter	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
HKD3_k127_3780575_14	34007.IT40_16965	2.715e-76	278.0	COG1893@1|root,COG1893@2|Bacteria,1P0AW@1224|Proteobacteria,2VEXI@28211|Alphaproteobacteria,2PXS5@265|Paracoccus	28211|Alphaproteobacteria	H	Ketopantoate reductase PanE/ApbA C terminal	-	-	1.1.1.169	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R02472	RC00726	ko00000,ko00001,ko00002,ko01000	-	-	-	ApbA,ApbA_C
HKD3_k127_3780575_13	488538.SAR116_0928	1.288e-80	291.0	COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,2TR61@28211|Alphaproteobacteria,4BR84@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	E	ATPases associated with a variety of cellular activities	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
HKD3_k127_3780575_6	488538.SAR116_0929	9.955e-106	352.0	COG0559@1|root,COG0559@2|Bacteria,1MU25@1224|Proteobacteria,2TSDS@28211|Alphaproteobacteria,4BR8B@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	E	Branched-chain amino acid transport system / permease component	MA20_19445	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HKD3_k127_3780575_15	488538.SAR116_0918	3.241e-37	159.0	COG3971@1|root,COG3971@2|Bacteria,1MVVV@1224|Proteobacteria,2TSWB@28211|Alphaproteobacteria,4BQRZ@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	Q	2-keto-4-pentenoate hydratase	-	-	4.2.1.80	ko:K02554	ko00360,ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00360,map00362,map00621,map00622,map01100,map01120,map01220	M00545,M00569	R02601,R04781	RC00750,RC01213	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	FAA_hydrolase
HKD3_k127_3795946_3	56110.Oscil6304_3682	1.93e-43	180.0	COG0438@1|root,COG0457@1|root,COG0859@1|root,COG0438@2|Bacteria,COG0457@2|Bacteria,COG0859@2|Bacteria,1G193@1117|Cyanobacteria,1H799@1150|Oscillatoriales	1117|Cyanobacteria	M	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	DUF4915,Glyco_transf_9,Glycos_transf_1,TPR_1,TPR_11,TPR_16,TPR_17,TPR_2,TPR_8
HKD3_k127_3795946_5	557598.LHK_03041	3.09e-06	60.0	COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,2VHDH@28216|Betaproteobacteria,2KPQF@206351|Neisseriales	206351|Neisseriales	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	-	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
HKD3_k127_3795946_2	395495.Lcho_0974	1.8e-50	201.0	2CFS3@1|root,32S2D@2|Bacteria,1N23S@1224|Proteobacteria,2W4T1@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_3795946_1	472759.Nhal_3655	1.431e-66	253.0	28KU1@1|root,2ZAAZ@2|Bacteria,1R3VB@1224|Proteobacteria,1RYZK@1236|Gammaproteobacteria,1WWZ6@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_3795946_4	323261.Noc_2890	5.93e-33	144.0	2E2CQ@1|root,32XHP@2|Bacteria,1N13G@1224|Proteobacteria,1S9SS@1236|Gammaproteobacteria,1WYUI@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_3795946_0	269084.syc2069_c	2.859e-124	416.0	COG2148@1|root,COG2148@2|Bacteria,1G67M@1117|Cyanobacteria,1H45N@1129|Synechococcus	1117|Cyanobacteria	M	Bacterial sugar transferase	-	-	-	ko:K03606	ko05111,map05111	-	-	-	ko00000,ko00001	-	-	-	Bac_transf,CoA_binding_3
HKD3_k127_3795946_6	1121422.AUMW01000015_gene2612	0.0006667	44.0	COG1215@1|root,COG1215@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2,GtrA
HKD3_k127_3823209_5	279714.FuraDRAFT_3919	2.603e-22	98.0	COG1167@1|root,COG1167@2|Bacteria,1MVGT@1224|Proteobacteria,2VK4P@28216|Betaproteobacteria	28216|Betaproteobacteria	K	COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs	-	-	-	ko:K00375	-	-	-	-	ko00000,ko03000	-	-	-	Aminotran_1_2,GntR
HKD3_k127_3823209_0	1411123.JQNH01000001_gene3809	2.825e-180	578.0	COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,2TQND@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	bioA	-	2.6.1.18	ko:K00822	ko00280,ko00410,ko00640,ko01100,map00280,map00410,map00640,map01100	-	R00907,R04187	RC00008,RC00062,RC00160	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_3
HKD3_k127_3823209_2	748247.AZKH_2607	1.504e-122	423.0	COG4521@1|root,COG4521@2|Bacteria,1MVH2@1224|Proteobacteria,2VINJ@28216|Betaproteobacteria	28216|Betaproteobacteria	P	taurine ABC transporter, periplasmic binding protein	tauA1	-	-	ko:K15551	ko00920,ko02010,map00920,map02010	M00435	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.17.1,3.A.1.17.4	-	-	NMT1
HKD3_k127_3823209_3	264198.Reut_A1471	6.254e-118	384.0	COG4525@1|root,COG4525@2|Bacteria,1QTUA@1224|Proteobacteria,2VIKA@28216|Betaproteobacteria,1K2BN@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system	tauB	-	3.6.3.36	ko:K10831	ko00920,ko02010,map00920,map02010	M00435	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.17.1,3.A.1.17.4	-	-	ABC_tran
HKD3_k127_3823209_1	1366050.N234_05795	2.864e-124	417.0	COG0600@1|root,COG0600@2|Bacteria,1MWDJ@1224|Proteobacteria,2VJM9@28216|Betaproteobacteria,1K0NT@119060|Burkholderiaceae	28216|Betaproteobacteria	P	binding-protein-dependent transport systems inner membrane component	tauC	-	-	ko:K02050,ko:K15552	ko00920,ko02010,map00920,map02010	M00188,M00435	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.16,3.A.1.17,3.A.1.17.1,3.A.1.17.4	-	-	BPD_transp_1
HKD3_k127_3823209_4	644076.SCH4B_0041	1.233e-39	167.0	COG0664@1|root,COG0664@2|Bacteria,1QU34@1224|Proteobacteria	1224|Proteobacteria	T	COG1226 Kef-type K transport systems	-	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0042802,GO:0044464,GO:0071944	-	ko:K10716	-	-	-	-	ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	Ion_trans,Ion_trans_2,cNMP_binding
HKD3_k127_3823759_3	864051.BurJ1DRAFT_4844	1.617e-19	91.0	COG1011@1|root,COG1011@2|Bacteria,1MU1H@1224|Proteobacteria,2VN8N@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Haloacid dehalogenase, type II	-	-	3.8.1.2	ko:K01560	ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120	-	R05287	RC00697	ko00000,ko00001,ko01000	-	-	-	HAD_2,Hydrolase
HKD3_k127_3823759_0	666684.AfiDRAFT_2150	2.711e-155	497.0	COG1638@1|root,COG1638@2|Bacteria,1MWAW@1224|Proteobacteria,2TV91@28211|Alphaproteobacteria,3JRW0@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Bacterial extracellular solute-binding protein, family 7	MA20_30160	-	-	-	-	-	-	-	-	-	-	-	DctP
HKD3_k127_3823759_2	883080.HMPREF9697_00862	8.484e-64	238.0	COG3090@1|root,COG3090@2|Bacteria,1MVKS@1224|Proteobacteria,2U08K@28211|Alphaproteobacteria,3JQRU@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Tripartite ATP-independent periplasmic transporters, DctQ component	MA20_30165	-	-	-	-	-	-	-	-	-	-	-	DctQ
HKD3_k127_3823759_1	666684.AfiDRAFT_2148	1.69e-111	375.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2TQW5@28211|Alphaproteobacteria,3JTXU@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Tripartite ATP-independent periplasmic transporter, DctM component	MA20_30170	-	-	-	-	-	-	-	-	-	-	-	DctM
HKD3_k127_3865446_2	626418.bglu_1g31260	1.324e-08	66.0	COG2802@1|root,COG2802@2|Bacteria,1RFYH@1224|Proteobacteria,2VSA4@28216|Betaproteobacteria,1JZR8@119060|Burkholderiaceae	28216|Betaproteobacteria	S	PFAM peptidase S16 lon domain protein	-	-	-	ko:K07157	-	-	-	-	ko00000	-	-	-	LON_substr_bdg
HKD3_k127_3865446_0	1454004.AW11_01509	2.315e-85	287.0	COG0163@1|root,COG0163@2|Bacteria,1RA0P@1224|Proteobacteria,2VIWQ@28216|Betaproteobacteria,1KQZZ@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	H	Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN	ubiX	-	2.5.1.129	ko:K03186	ko00130,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00627,map00940,map01100,map01110,map01120,map01220	M00117	R01238,R02952,R03367,R04985,R04986,R11225	RC00391,RC00814,RC03392	ko00000,ko00001,ko00002,ko01000	-	-	-	Flavoprotein
HKD3_k127_3865446_1	323848.Nmul_A0081	5.381e-85	288.0	COG1660@1|root,COG1660@2|Bacteria,1MVX6@1224|Proteobacteria,2VIH5@28216|Betaproteobacteria,372SK@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Displays ATPase and GTPase activities	yhbJ	-	-	ko:K06958	-	-	-	-	ko00000,ko03019	-	-	-	ATP_bind_2
HKD3_k127_3882575_0	748280.NH8B_2498	9.143e-194	613.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2VIF8@28216|Betaproteobacteria,2KPUM@206351|Neisseriales	206351|Neisseriales	I	Belongs to the thiolase family	-	-	2.3.1.16,2.3.1.9	ko:K00626,ko:K00632	ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00087,M00088,M00095,M00113,M00373,M00374,M00375	R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
HKD3_k127_3882575_3	1031711.RSPO_c01176	4.83e-140	459.0	COG2057@1|root,COG2057@2|Bacteria,1MWW1@1224|Proteobacteria,2VIBE@28216|Betaproteobacteria,1K086@119060|Burkholderiaceae	28216|Betaproteobacteria	I	TIGRFAM 3-oxoacid CoA-transferase, B subunit	pcaJ	-	2.8.3.6	ko:K01032	ko00362,ko01100,ko01120,map00362,map01100,map01120	-	R02990	RC00014	ko00000,ko00001,ko01000	-	-	-	CoA_trans
HKD3_k127_3882575_4	1454004.AW11_03546	9.203e-138	448.0	COG1219@1|root,COG1219@2|Bacteria,1R8FT@1224|Proteobacteria,2VM85@28216|Betaproteobacteria,1KR7C@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	O	MCM2/3/5 family	-	-	-	ko:K03544	ko04112,map04112	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA_2,ClpB_D2-small
HKD3_k127_3882575_1	1218084.BBJK01000075_gene5239	5.54e-180	603.0	COG2909@1|root,COG3629@1|root,COG2909@2|Bacteria,COG3629@2|Bacteria,1MVZZ@1224|Proteobacteria,2VXDK@28216|Betaproteobacteria,1K5E1@119060|Burkholderiaceae	28216|Betaproteobacteria	K	Bacterial transcriptional activator domain	-	-	-	-	-	-	-	-	-	-	-	-	BTAD
HKD3_k127_3882575_2	1041138.KB890226_gene6307	2.585e-148	492.0	COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,4BA4K@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	Adenylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Trans_reg_C
HKD3_k127_3882575_5	75379.Tint_0707	1.053e-46	184.0	COG2010@1|root,COG2010@2|Bacteria,1N0EF@1224|Proteobacteria,2VT6G@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Cytochrome c mono- and diheme variants	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C
HKD3_k127_3882575_6	1085623.GNIT_1344	3.314e-12	66.0	COG0017@1|root,COG0017@2|Bacteria,1MWFV@1224|Proteobacteria,1RMU4@1236|Gammaproteobacteria,464RC@72275|Alteromonadaceae	1236|Gammaproteobacteria	J	COG0017 Aspartyl asparaginyl-tRNA synthetases	asnS	GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004816,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006421,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.1.1.22	ko:K01893	ko00970,map00970	M00359,M00360	R03648	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iSDY_1059.SDY_2327	tRNA-synt_2,tRNA_anti-codon
HKD3_k127_3889242_15	1125973.JNLC01000015_gene3399	3.969e-86	290.0	COG1884@1|root,COG1884@2|Bacteria,1MUXX@1224|Proteobacteria,2U39P@28211|Alphaproteobacteria,3K37Z@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	Methylmalonyl-CoA mutase	-	-	5.4.99.2,5.4.99.64	ko:K01848,ko:K20906	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	MM_CoA_mutase
HKD3_k127_3889242_11	443152.MDG893_09611	5.642e-107	359.0	COG1703@1|root,COG1703@2|Bacteria,1MVI0@1224|Proteobacteria,1RP15@1236|Gammaproteobacteria,46AA6@72275|Alteromonadaceae	1236|Gammaproteobacteria	E	ArgK protein	-	-	-	-	-	-	-	-	-	-	-	-	ArgK
HKD3_k127_3889242_2	1125973.JNLC01000015_gene3397	1.428e-239	749.0	COG1541@1|root,COG1541@2|Bacteria,1MV1W@1224|Proteobacteria,2TRVF@28211|Alphaproteobacteria,3K2QU@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	H	AMP-binding enzyme C-terminal domain	-	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C_2
HKD3_k127_3889242_20	78245.Xaut_5018	4.34e-55	202.0	COG2185@1|root,COG2185@2|Bacteria,1N56M@1224|Proteobacteria,2UEAN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	COG2185 Methylmalonyl-CoA mutase, C-terminal domain subunit (cobalamin-binding)	-	-	5.4.99.2,5.4.99.64	ko:K01849,ko:K20907	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding
HKD3_k127_3889242_31	386456.JQKN01000002_gene2431	8.851e-23	109.0	arCOG10857@1|root,arCOG10857@2157|Archaea,2Y4UI@28890|Euryarchaeota	28890|Euryarchaeota	S	Putative auto-transporter adhesin, head GIN domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF2807
HKD3_k127_3889242_32	243365.CV_1281	6.01e-22	109.0	28JEX@1|root,2Z98Z@2|Bacteria,1R5IF@1224|Proteobacteria,2VNVG@28216|Betaproteobacteria,2KQ5M@206351|Neisseriales	206351|Neisseriales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_3889242_26	266264.Rmet_2036	2.82e-37	150.0	COG2836@1|root,COG2836@2|Bacteria,1RIGJ@1224|Proteobacteria,2VINE@28216|Betaproteobacteria,1K5VC@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Cytochrome C biogenesis protein transmembrane region	-	-	-	ko:K09792	-	-	-	-	ko00000	-	-	-	DsbD_2
HKD3_k127_3889242_16	640081.Dsui_1646	6.203e-86	303.0	COG0664@1|root,COG0664@2|Bacteria,1MVGE@1224|Proteobacteria,2VH04@28216|Betaproteobacteria,2KUDT@206389|Rhodocyclales	206389|Rhodocyclales	K	COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases	fnr	-	-	ko:K01420	-	-	-	-	ko00000,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
HKD3_k127_3889242_30	391735.Veis_1164	7.813e-24	112.0	2EFX9@1|root,339PI@2|Bacteria,1NI0D@1224|Proteobacteria,2VU0U@28216|Betaproteobacteria,4AF5J@80864|Comamonadaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_3889242_28	640081.Dsui_1632	9.359e-28	130.0	COG3198@1|root,COG3198@2|Bacteria,1N75J@1224|Proteobacteria,2VTYE@28216|Betaproteobacteria,2KX1A@206389|Rhodocyclales	206389|Rhodocyclales	S	FixH family	-	-	-	ko:K09926	-	-	-	-	ko00000	-	-	-	FixH
HKD3_k127_3889242_5	983917.RGE_11620	1.137e-193	615.0	COG0348@1|root,COG0348@2|Bacteria,1MVFY@1224|Proteobacteria,2VHRH@28216|Betaproteobacteria,1KIYJ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	cytochrome C oxidase	ccoG	-	-	-	-	-	-	-	-	-	-	-	Fer4_18,Fer4_5,FixG_C
HKD3_k127_3889242_10	279714.FuraDRAFT_1094	2.759e-114	379.0	COG2010@1|root,COG2010@2|Bacteria,1MUCW@1224|Proteobacteria,2VHGS@28216|Betaproteobacteria,2KQ3Y@206351|Neisseriales	206351|Neisseriales	C	Cytochrome c oxidase, subunit	ccoP	-	-	ko:K00406	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002	3.D.4.3	-	-	Cytochrome_CBB3,FixP_N,OmpA
HKD3_k127_3889242_34	1397528.Q671_03745	3.013e-07	54.0	COG4736@1|root,COG4736@2|Bacteria,1NGAN@1224|Proteobacteria,1SGJ2@1236|Gammaproteobacteria,1XMQT@135619|Oceanospirillales	135619|Oceanospirillales	O	Cbb3-type cytochrome oxidase component FixQ	ccoQ	-	-	ko:K00407	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002	3.D.4.3	-	-	FixQ
HKD3_k127_3889242_12	760117.JN27_04155	3.884e-102	336.0	COG2993@1|root,COG2993@2|Bacteria,1MXEY@1224|Proteobacteria,2VIJ2@28216|Betaproteobacteria,472VR@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	Cytochrome C oxidase, mono-heme subunit/FixO	ccoO	-	-	ko:K00405	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002	3.D.4.3	-	-	FixO
HKD3_k127_3889242_0	1123354.AUDR01000018_gene1214	1.968e-267	831.0	COG3278@1|root,COG3278@2|Bacteria,1MU18@1224|Proteobacteria,2VIWB@28216|Betaproteobacteria,1KRDD@119069|Hydrogenophilales	119069|Hydrogenophilales	C	Cytochrome C and Quinol oxidase polypeptide I	-	-	1.9.3.1	ko:K00404	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	COX1
HKD3_k127_3889242_33	243365.CV_2041	5.881e-14	76.0	COG3197@1|root,COG3197@2|Bacteria,1NG90@1224|Proteobacteria,2VWG5@28216|Betaproteobacteria,2KS1K@206351|Neisseriales	206351|Neisseriales	P	cytochrome oxidase maturation protein cbb3-type	ccoS	-	-	-	-	-	-	-	-	-	-	-	FixS
HKD3_k127_3889242_4	1121035.AUCH01000016_gene2216	9.905e-218	703.0	COG2217@1|root,COG2608@1|root,COG2217@2|Bacteria,COG2608@2|Bacteria,1MU08@1224|Proteobacteria,2VJSM@28216|Betaproteobacteria,2KV1V@206389|Rhodocyclales	206389|Rhodocyclales	P	cation transport ATPase	ccoI	-	3.6.3.4	ko:K01533	-	-	R00086	RC00002	ko00000,ko01000	3.A.3.5	-	-	ATPase-cat_bd,E1-E2_ATPase,HMA,Hydrolase
HKD3_k127_3889242_25	1123354.AUDR01000018_gene1207	1.581e-37	146.0	COG0589@1|root,COG0589@2|Bacteria,1MZ3K@1224|Proteobacteria,2VR37@28216|Betaproteobacteria	28216|Betaproteobacteria	T	universal stress protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD3_k127_3889242_1	1458357.BG58_39975	6.143e-249	782.0	COG0442@1|root,COG0442@2|Bacteria,1MU7E@1224|Proteobacteria,2VGZ9@28216|Betaproteobacteria,1K28Y@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS	proS	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA_edit
HKD3_k127_3889242_18	1123393.KB891316_gene1421	7.562e-65	228.0	COG0741@1|root,COG0741@2|Bacteria,1R666@1224|Proteobacteria,2VHI4@28216|Betaproteobacteria,1KRNS@119069|Hydrogenophilales	119069|Hydrogenophilales	M	Transglycosylase SLT domain	-	-	-	-	-	-	-	-	-	-	-	-	SLT
HKD3_k127_3889242_13	580332.Slit_0964	3.148e-97	338.0	COG0008@1|root,COG0008@2|Bacteria,1MUN7@1224|Proteobacteria,2VHYK@28216|Betaproteobacteria,44VQH@713636|Nitrosomonadales	28216|Betaproteobacteria	J	Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon	gluQ	-	-	ko:K01894	-	-	-	-	ko00000,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1c
HKD3_k127_3889242_17	580332.Slit_0387	1.688e-73	253.0	COG5405@1|root,COG5405@2|Bacteria,1RAFD@1224|Proteobacteria,2VMEF@28216|Betaproteobacteria	28216|Betaproteobacteria	O	PFAM 20S proteasome, A and B subunits	-	-	3.4.25.2	ko:K01419	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Proteasome
HKD3_k127_3889242_21	1485544.JQKP01000010_gene821	5.415e-53	211.0	COG1281@1|root,COG1281@2|Bacteria,1MUMU@1224|Proteobacteria,2VI8B@28216|Betaproteobacteria,44V88@713636|Nitrosomonadales	28216|Betaproteobacteria	O	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress	hslO	-	-	ko:K04083	-	-	-	-	ko00000,ko03110	-	-	-	HSP33
HKD3_k127_3889242_22	1396141.BATP01000040_gene2083	5.812e-50	186.0	COG0454@1|root,COG2808@1|root,COG0456@2|Bacteria,COG2808@2|Bacteria,46U0E@74201|Verrucomicrobia,2IUJ5@203494|Verrucomicrobiae	203494|Verrucomicrobiae	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_10,Acetyltransf_7,SnoaL_2
HKD3_k127_3889242_29	1236959.BAMT01000009_gene3423	7.143e-27	117.0	COG1188@1|root,COG1188@2|Bacteria,1MZR6@1224|Proteobacteria,2VTY8@28216|Betaproteobacteria,2KMTC@206350|Nitrosomonadales	206350|Nitrosomonadales	J	PFAM RNA-binding S4 domain protein	-	-	-	ko:K04762	-	-	-	-	ko00000,ko03110	-	-	-	S4
HKD3_k127_3889242_23	62928.azo3308	1.692e-42	173.0	COG0789@1|root,COG5012@1|root,COG0789@2|Bacteria,COG5012@2|Bacteria,1R2NF@1224|Proteobacteria,2VJDG@28216|Betaproteobacteria,2KW35@206389|Rhodocyclales	206389|Rhodocyclales	K	B12 binding domain	-	-	-	ko:K22491	-	-	-	-	ko00000,ko03000	-	-	-	B12-binding,B12-binding_2,MerR_1
HKD3_k127_3889242_24	1123392.AQWL01000004_gene2747	9.57e-40	168.0	2DBUQ@1|root,2ZB76@2|Bacteria,1R4DM@1224|Proteobacteria,2VS5V@28216|Betaproteobacteria,1KSNQ@119069|Hydrogenophilales	119069|Hydrogenophilales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_3889242_3	1095769.CAHF01000010_gene1221	3.412e-231	728.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2VJ5E@28216|Betaproteobacteria,475GZ@75682|Oxalobacteraceae	28216|Betaproteobacteria	I	AMP-binding enzyme C-terminal domain	bclA_2	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
HKD3_k127_3889242_27	713586.KB900536_gene1113	4.367e-33	139.0	2EKTI@1|root,33EH9@2|Bacteria,1PYIF@1224|Proteobacteria,1SHX2@1236|Gammaproteobacteria,1X1YZ@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_3889242_19	1268622.AVS7_02723	1.11e-58	208.0	COG4083@1|root,COG4083@2|Bacteria,1RI8D@1224|Proteobacteria,2VY0W@28216|Betaproteobacteria	28216|Betaproteobacteria	S	PFAM Transmembrane exosortase (Exosortase_EpsH)	-	-	-	-	-	-	-	-	-	-	-	-	Exosortase_EpsH
HKD3_k127_3889242_9	640081.Dsui_3500	3.96e-127	419.0	COG0860@1|root,COG0860@2|Bacteria,1MUQK@1224|Proteobacteria,2VHXN@28216|Betaproteobacteria,2KV54@206389|Rhodocyclales	206389|Rhodocyclales	M	N-acetylmuramoyl-L-alanine amidase	-	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	AMIN,Amidase_3
HKD3_k127_3889242_7	292415.Tbd_1520	1.859e-153	497.0	COG1600@1|root,COG1600@2|Bacteria,1MV1H@1224|Proteobacteria,2VI7V@28216|Betaproteobacteria,1KRDQ@119069|Hydrogenophilales	119069|Hydrogenophilales	C	Domain of unknown function (DUF1730)	-	-	1.17.99.6	ko:K18979	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DUF1730,Fer4_16
HKD3_k127_3889242_14	1163617.SCD_n01316	4.459e-90	329.0	COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,2VM1X@28216|Betaproteobacteria	28216|Betaproteobacteria	U	General secretion pathway protein F	gspF	-	-	ko:K02455	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSF
HKD3_k127_3889242_6	1123368.AUIS01000003_gene1764	8.665e-183	589.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,1RMBS@1236|Gammaproteobacteria,2NCBG@225057|Acidithiobacillales	1236|Gammaproteobacteria	NU	Type II secretion system (T2SS), protein E, N-terminal domain	gspE	-	-	ko:K02454	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSE
HKD3_k127_3889242_8	1163408.UU9_12123	5.383e-145	479.0	COG1450@1|root,COG1450@2|Bacteria,1MUUA@1224|Proteobacteria,1RPJS@1236|Gammaproteobacteria,1X4RY@135614|Xanthomonadales	135614|Xanthomonadales	NU	secretion system protein	xcsD	-	-	ko:K02453	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	Secretin,Secretin_N
HKD3_k127_3908525_1	522306.CAP2UW1_0165	5.462e-180	586.0	COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,2VI5V@28216|Betaproteobacteria,1KQSR@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	M	TIGRFAM RND efflux system, outer membrane lipoprotein, NodT family	-	-	-	ko:K18139	ko01501,ko02024,map01501,map02024	M00642,M00643,M00647,M00718,M00768,M00822	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	1.B.17,2.A.6.2	-	-	OEP
HKD3_k127_3908525_0	977880.RALTA_A2813	0.0	1224.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHFI@28216|Betaproteobacteria,1K0FI@119060|Burkholderiaceae	28216|Betaproteobacteria	V	Efflux pump membrane transporter	-	-	-	ko:K03296,ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
HKD3_k127_3908525_2	398527.Bphyt_4148	6.186e-128	423.0	COG0845@1|root,COG0845@2|Bacteria,1MU78@1224|Proteobacteria,2VINC@28216|Betaproteobacteria,1K24M@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	HlyD_D23,OmpA
HKD3_k127_3908525_4	530564.Psta_3485	1.372e-68	241.0	COG0671@1|root,COG0671@2|Bacteria,2IZAS@203682|Planctomycetes	203682|Planctomycetes	I	LssY C-terminus	-	-	-	-	-	-	-	-	-	-	-	-	LssY_C
HKD3_k127_3908525_6	420324.KI912013_gene9358	8.494e-60	220.0	COG2207@1|root,COG2207@2|Bacteria,1MX23@1224|Proteobacteria,2TT6H@28211|Alphaproteobacteria,1JRS3@119045|Methylobacteriaceae	28211|Alphaproteobacteria	K	PFAM helix-turn-helix- domain containing protein AraC type	-	-	-	-	-	-	-	-	-	-	-	-	Arabinose_bd,HTH_18
HKD3_k127_3908525_5	187272.Mlg_2026	2.241e-65	229.0	COG0680@1|root,COG0680@2|Bacteria,1RE1C@1224|Proteobacteria,1S4H2@1236|Gammaproteobacteria,1WXZI@135613|Chromatiales	135613|Chromatiales	C	Hydrogenase expression formation protein	-	-	-	ko:K03605	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	HycI
HKD3_k127_3908525_9	187303.BN69_2333	2.641e-23	103.0	COG0298@1|root,COG0298@2|Bacteria,1N9Z3@1224|Proteobacteria,2UD4G@28211|Alphaproteobacteria,3717U@31993|Methylocystaceae	28211|Alphaproteobacteria	O	HupF/HypC family	hupF	-	-	ko:K04653	-	-	-	-	ko00000	-	-	-	HupF_HypC
HKD3_k127_3908525_7	187272.Mlg_2024	1.625e-28	128.0	COG3118@1|root,COG3118@2|Bacteria,1QVD0@1224|Proteobacteria,1T2X7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	Hydrogenase-1 expression protein HyaE	-	-	-	ko:K03619	-	-	-	-	ko00000	-	-	-	HyaE
HKD3_k127_3908525_3	1192124.LIG30_1252	4.215e-71	250.0	COG1773@1|root,COG1773@2|Bacteria,1MV2U@1224|Proteobacteria,2VKNQ@28216|Betaproteobacteria,1K5MW@119060|Burkholderiaceae	28216|Betaproteobacteria	C	PFAM HupH hydrogenase expression protein	hoxQ	-	-	ko:K03618	-	-	-	-	ko00000	-	-	-	HupH_C
HKD3_k127_3908525_8	1458427.BAWN01000033_gene1894	3.424e-24	103.0	COG1773@1|root,COG1773@2|Bacteria,1N6TQ@1224|Proteobacteria,2VWD0@28216|Betaproteobacteria,4AID5@80864|Comamonadaceae	28216|Betaproteobacteria	C	Rubredoxin	hoxR	-	-	-	-	-	-	-	-	-	-	-	Rubredoxin
HKD3_k127_3921486_1	1168065.DOK_09534	6.105e-28	114.0	COG1024@1|root,COG1024@2|Bacteria,1MWZC@1224|Proteobacteria,1S5P6@1236|Gammaproteobacteria,1J8EX@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
HKD3_k127_3921486_0	1168065.DOK_06702	5.638e-156	505.0	COG1804@1|root,COG1804@2|Bacteria,1MW1H@1224|Proteobacteria,1RN9B@1236|Gammaproteobacteria,1J4MI@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	acyl-CoA transferases carnitine dehydratase	-	-	5.1.99.4	ko:K01796	ko00120,ko01100,ko04146,map00120,map01100,map04146	M00104	R08734,R08739	RC02345	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_transf_3
HKD3_k127_3946909_18	85643.Tmz1t_1691	1.22e-47	173.0	COG0195@1|root,COG0195@2|Bacteria,1MWT7@1224|Proteobacteria,2VH2X@28216|Betaproteobacteria,2KVE3@206389|Rhodocyclales	206389|Rhodocyclales	K	Participates in both transcription termination and antitermination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	HHH_5,KH_5,NusA_N,S1
HKD3_k127_3946909_0	76114.ebA5841	0.0	1090.0	COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,2VK2H@28216|Betaproteobacteria,2KV2V@206389|Rhodocyclales	206389|Rhodocyclales	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,IF-2,IF2_N,IF2_assoc
HKD3_k127_3946909_21	1163617.SCD_n01714	6.732e-37	144.0	COG0858@1|root,COG0858@2|Bacteria,1MZPE@1224|Proteobacteria,2VR43@28216|Betaproteobacteria	28216|Betaproteobacteria	J	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA	rbfA	-	-	ko:K02834	-	-	-	-	ko00000,ko03009	-	-	-	RBFA
HKD3_k127_3946909_8	395019.Bmul_1753	5.012e-86	295.0	COG0130@1|root,COG0130@2|Bacteria,1MV0N@1224|Proteobacteria,2VH97@28216|Betaproteobacteria,1K0BF@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs	truB	-	5.4.99.25	ko:K03177	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruB-C_2,TruB_C_2,TruB_N
HKD3_k127_3946909_20	62928.azo2104	1.11e-38	146.0	COG0184@1|root,COG0184@2|Bacteria,1MZ2W@1224|Proteobacteria,2VU1D@28216|Betaproteobacteria,2KX1E@206389|Rhodocyclales	206389|Rhodocyclales	J	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome	rpsO	-	-	ko:K02956	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S15
HKD3_k127_3946909_1	1304883.KI912532_gene2229	0.0	1039.0	COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,2VI1P@28216|Betaproteobacteria,2KUVE@206389|Rhodocyclales	206389|Rhodocyclales	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	-	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
HKD3_k127_3946909_12	1245469.S58_62160	1.764e-71	252.0	COG0346@1|root,COG0346@2|Bacteria,1P5FR@1224|Proteobacteria,2TVCC@28211|Alphaproteobacteria,3JSK6@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	MA20_35815	-	1.13.11.25	ko:K16049	ko00984,ko01100,ko01120,ko01220,map00984,map01100,map01120,map01220	-	R04597	RC01610	ko00000,ko00001,ko01000	-	-	-	Glyoxalase
HKD3_k127_3946909_27	1392838.AWNM01000070_gene1282	2.535e-16	92.0	COG3471@1|root,COG3471@2|Bacteria,1MZA2@1224|Proteobacteria,2VQW2@28216|Betaproteobacteria,3T42E@506|Alcaligenaceae	28216|Betaproteobacteria	S	Protein of unknown function (DUF541)	-	-	-	-	-	-	-	-	-	-	-	-	SIMPL
HKD3_k127_3946909_15	1485544.JQKP01000020_gene66	2.323e-54	202.0	COG0494@1|root,COG0494@2|Bacteria,1RH6N@1224|Proteobacteria,2VR3U@28216|Betaproteobacteria,44VVC@713636|Nitrosomonadales	28216|Betaproteobacteria	L	NUDIX domain	ntpA	-	3.6.1.67	ko:K08310	ko00790,map00790	M00126	R04638	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NUDIX
HKD3_k127_3946909_26	62928.azo3242	3.168e-19	92.0	COG2732@1|root,COG2732@2|Bacteria,1NKY3@1224|Proteobacteria,2WA11@28216|Betaproteobacteria,2KXMV@206389|Rhodocyclales	206389|Rhodocyclales	K	Barstar (barnase inhibitor)	-	-	-	-	-	-	-	-	-	-	-	-	Barstar
HKD3_k127_3946909_28	644107.SL1157_2956	0.0005687	47.0	COG1043@1|root,COG1043@2|Bacteria,1MUHQ@1224|Proteobacteria,2TRK9@28211|Alphaproteobacteria,4N9WQ@97050|Ruegeria	28211|Alphaproteobacteria	M	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxA	-	2.3.1.129	ko:K00677	ko00540,ko01100,ko01503,map00540,map01100,map01503	M00060	R04567	RC00039,RC00055	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Acetyltransf_11,Hexapep
HKD3_k127_3946909_23	1112214.AHIS01000095_gene844	1.203e-32	131.0	2AJZ7@1|root,31ANF@2|Bacteria,1NDRQ@1224|Proteobacteria,2UU0D@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_3946909_11	697282.Mettu_3742	3.553e-74	263.0	COG3591@1|root,COG3591@2|Bacteria,1QZ6Z@1224|Proteobacteria,1RRNA@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	Trypsin-like peptidase domain	-	-	-	-	-	-	-	-	-	-	-	-	Trypsin_2
HKD3_k127_3946909_22	1268622.AVS7_00937	1.365e-33	150.0	COG4290@1|root,COG4290@2|Bacteria,1MZEZ@1224|Proteobacteria,2VTZ7@28216|Betaproteobacteria,4AEXX@80864|Comamonadaceae	28216|Betaproteobacteria	F	guanine-specific ribonuclease N1 and T1	rnaSA	-	3.1.27.3	ko:K01167	-	-	-	-	ko00000,ko01000,ko03016,ko03019	-	-	-	Ribonuclease
HKD3_k127_3946909_2	469610.HMPREF0189_01402	4.236e-288	895.0	COG0173@1|root,COG0173@2|Bacteria,1MUXB@1224|Proteobacteria,2VHKQ@28216|Betaproteobacteria,1KITM@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
HKD3_k127_3946909_10	1000565.METUNv1_02900	2.022e-77	268.0	COG2928@1|root,COG2928@2|Bacteria,1MWT5@1224|Proteobacteria,2VH65@28216|Betaproteobacteria,2KV5C@206389|Rhodocyclales	206389|Rhodocyclales	S	Protein of unknown function (DUF502)	-	-	-	-	-	-	-	-	-	-	-	-	DUF502
HKD3_k127_3946909_25	864051.BurJ1DRAFT_1303	1.732e-26	113.0	COG2331@1|root,COG2331@2|Bacteria,1N6Q9@1224|Proteobacteria,2VTX5@28216|Betaproteobacteria,1KMDJ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Regulatory protein, FmdB family	-	-	-	-	-	-	-	-	-	-	-	-	Zn-ribbon_8
HKD3_k127_3946909_24	580332.Slit_1574	2.475e-27	118.0	COG1585@1|root,COG1585@2|Bacteria,1PT3V@1224|Proteobacteria,2WADK@28216|Betaproteobacteria,44W42@713636|Nitrosomonadales	28216|Betaproteobacteria	OU	NfeD-like C-terminal, partner-binding	-	-	-	-	-	-	-	-	-	-	-	-	NfeD
HKD3_k127_3946909_6	1144342.PMI40_03571	2.665e-127	434.0	COG0330@1|root,COG0330@2|Bacteria,1MUM8@1224|Proteobacteria,2VHBD@28216|Betaproteobacteria,47242@75682|Oxalobacteraceae	28216|Betaproteobacteria	O	C-terminal region of band_7	qmcA	-	-	-	-	-	-	-	-	-	-	-	Band_7,Band_7_C
HKD3_k127_3946909_7	7159.AAEL015588-PA	7.254e-95	333.0	KOG1199@1|root,KOG1199@2759|Eukaryota,38CCA@33154|Opisthokonta,3BD0V@33208|Metazoa,3CY8V@33213|Bilateria,41TTR@6656|Arthropoda,3SIZ9@50557|Insecta,452SZ@7147|Diptera,45GDF@7148|Nematocera	33208|Metazoa	Q	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	1.1.1.178,1.1.1.35	ko:K08683	ko00280,ko01100,ko01110,ko01130,ko05010,map00280,map01100,map01110,map01130,map05010	-	R04203	RC00525	ko00000,ko00001,ko01000,ko03029,ko04147	-	-	-	adh_short,adh_short_C2
HKD3_k127_3946909_19	748280.NH8B_2621	7.195e-45	184.0	COG1495@1|root,COG1495@2|Bacteria,1RIJE@1224|Proteobacteria,2VREE@28216|Betaproteobacteria,2KTVE@206351|Neisseriales	206351|Neisseriales	C	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein	dsbB	-	-	ko:K03611	-	-	-	-	ko00000,ko03110	5.A.2.1	-	-	DsbB
HKD3_k127_3946909_4	1123367.C666_14405	3.566e-215	674.0	COG2873@1|root,COG2873@2|Bacteria,1NQME@1224|Proteobacteria,2VHYA@28216|Betaproteobacteria,2KV3P@206389|Rhodocyclales	206389|Rhodocyclales	E	Cys/Met metabolism PLP-dependent enzyme	-	-	2.5.1.49	ko:K01740	ko00270,ko01100,map00270,map01100	-	R01287,R04859	RC00020,RC02821,RC02848	ko00000,ko00001,ko01000	-	-	-	Cys_Met_Meta_PP
HKD3_k127_3946909_14	62928.azo0744	1.791e-64	224.0	COG1832@1|root,COG1832@2|Bacteria,1N03D@1224|Proteobacteria,2VU9G@28216|Betaproteobacteria,2KWFV@206389|Rhodocyclales	206389|Rhodocyclales	S	CoA-binding protein	-	-	-	ko:K06929	-	-	-	-	ko00000	-	-	-	CoA_binding_2
HKD3_k127_3946909_16	29581.BW37_05330	4.854e-49	192.0	COG3134@1|root,COG3134@2|Bacteria,1MY27@1224|Proteobacteria,2WA14@28216|Betaproteobacteria,477BS@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Beta/gamma crystallins	-	-	-	-	-	-	-	-	-	-	-	-	Crystall
HKD3_k127_3946909_5	1198452.Jab_1c24210	9.709e-141	497.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,472C3@75682|Oxalobacteraceae	28216|Betaproteobacteria	T	Putative diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GAF_2,GGDEF,HAMP,PAS,PAS_3,PAS_9,Response_reg
HKD3_k127_3946909_17	314278.NB231_01484	4.61e-48	188.0	COG2267@1|root,COG2267@2|Bacteria,1PWD0@1224|Proteobacteria,1S8KS@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
HKD3_k127_3946909_9	519989.ECTPHS_10346	9.07e-80	274.0	COG1573@1|root,COG1573@2|Bacteria,1MW91@1224|Proteobacteria,1S2B6@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	uracil-DNA glycosylase	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
HKD3_k127_3946909_3	1163617.SCD_n01293	9.865e-228	722.0	COG0322@1|root,COG0322@2|Bacteria,1MV38@1224|Proteobacteria,2VIM4@28216|Betaproteobacteria	28216|Betaproteobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	-	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH,HHH_2,HHH_5,UVR,UvrC_HhH_N
HKD3_k127_3946909_13	557598.LHK_02626	3.568e-71	246.0	COG0558@1|root,COG0558@2|Bacteria,1RCZ7@1224|Proteobacteria,2VQI2@28216|Betaproteobacteria,2KQW4@206351|Neisseriales	206351|Neisseriales	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pgsA	-	2.7.8.41,2.7.8.5	ko:K00995,ko:K08744	ko00564,ko01100,map00564,map01100	-	R01801,R02030	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
HKD3_k127_3954964_23	748280.NH8B_1055	2.189e-10	62.0	COG1397@1|root,COG1397@2|Bacteria,1NTUR@1224|Proteobacteria,2VM8T@28216|Betaproteobacteria	28216|Betaproteobacteria	O	ADP-ribosyl- dinitrogen reductase hydrolase	draG2	-	-	-	-	-	-	-	-	-	-	-	ADP_ribosyl_GH
HKD3_k127_3954964_20	1472716.KBK24_0128710	8.747e-35	145.0	COG3012@1|root,COG3318@1|root,COG3012@2|Bacteria,COG3318@2|Bacteria,1R4KR@1224|Proteobacteria,2VSZR@28216|Betaproteobacteria,1K6MX@119060|Burkholderiaceae	28216|Betaproteobacteria	U	TIGRFAM yecA family protein	-	-	-	ko:K07039	-	-	-	-	ko00000	-	-	-	SEC-C,UPF0149
HKD3_k127_3954964_13	1007105.PT7_0628	3.313e-80	277.0	COG0664@1|root,COG0664@2|Bacteria,1R5P7@1224|Proteobacteria,2VIQI@28216|Betaproteobacteria,3T3I8@506|Alcaligenaceae	28216|Betaproteobacteria	K	Cyclic nucleotide-monophosphate binding domain	dnrD	-	-	ko:K21563	-	-	-	-	ko00000,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
HKD3_k127_3954964_16	1380394.JADL01000008_gene3523	3.071e-70	261.0	COG0235@1|root,COG0235@2|Bacteria,1MW7B@1224|Proteobacteria,2TSX7@28211|Alphaproteobacteria,2JRUR@204441|Rhodospirillales	204441|Rhodospirillales	G	Class II Aldolase and Adducin N-terminal domain	-	-	4.1.1.104	ko:K22130	-	-	-	-	ko00000,ko01000	-	-	-	Aldolase_II
HKD3_k127_3954964_8	1380394.JADL01000008_gene3522	3.187e-155	500.0	COG3395@1|root,COG3395@2|Bacteria,1MW4G@1224|Proteobacteria,2TS85@28211|Alphaproteobacteria,2JQNX@204441|Rhodospirillales	204441|Rhodospirillales	S	Putative sugar-binding N-terminal domain	-	-	2.7.1.217	ko:K21948	-	-	R11706,R11707	-	ko00000,ko01000	-	-	-	DUF1357_C,DUF1537
HKD3_k127_3954964_22	1123368.AUIS01000008_gene2154	3.141e-15	78.0	COG0425@1|root,COG0425@2|Bacteria,1QU8C@1224|Proteobacteria,1T5JF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	Uncharacterized conserved protein (DUF2249)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2249
HKD3_k127_3954964_10	1288494.EBAPG3_12710	1.812e-130	427.0	COG1612@1|root,COG1612@2|Bacteria,1MVJ4@1224|Proteobacteria,2WAY9@28216|Betaproteobacteria,371NX@32003|Nitrosomonadales	28216|Betaproteobacteria	O	Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group	ctaA	-	-	ko:K02259	ko00190,ko00860,ko01100,ko01110,ko02020,ko04714,map00190,map00860,map01100,map01110,map02020,map04714	M00154	R07412	RC00769	ko00000,ko00001,ko00002,ko03029	3.D.4.4	-	-	COX15-CtaA
HKD3_k127_3954964_0	1123367.C666_01495	0.0	1737.0	COG2902@1|root,COG2902@2|Bacteria,1MXNV@1224|Proteobacteria,2VKIR@28216|Betaproteobacteria,2KVIK@206389|Rhodocyclales	206389|Rhodocyclales	E	Bacterial NAD-glutamate dehydrogenase	gdh	-	1.4.1.2	ko:K15371	ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100	-	R00243	RC00006,RC02799	ko00000,ko00001,ko01000	-	-	-	Bac_GDH
HKD3_k127_3954964_2	1380394.JADL01000013_gene659	0.0	1178.0	COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,2TRER@28211|Alphaproteobacteria,2JQ58@204441|Rhodospirillales	204441|Rhodospirillales	G	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties	glgP	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	Phosphorylase
HKD3_k127_3954964_6	1134912.AJTV01000020_gene3084	3.121e-212	667.0	COG0448@1|root,COG0448@2|Bacteria,1MVTC@1224|Proteobacteria,2TR6D@28211|Alphaproteobacteria,36XJN@31993|Methylocystaceae	28211|Alphaproteobacteria	G	Nucleotidyl transferase	glgC	-	2.7.7.27	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	M00565	R00948	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
HKD3_k127_3954964_7	316055.RPE_0800	3.904e-190	605.0	COG0297@1|root,COG0297@2|Bacteria,1MUGM@1224|Proteobacteria,2TT73@28211|Alphaproteobacteria,3JRIN@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Synthesizes alpha-1,4-glucan chains using ADP-glucose	glgA	GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0071704,GO:1901576	2.4.1.21	ko:K00703	ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026	M00565	R02421	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT5	-	Glyco_transf_5,Glycos_transf_1
HKD3_k127_3954964_1	1125973.JNLC01000012_gene917	0.0	1351.0	COG1523@1|root,COG1640@1|root,COG1523@2|Bacteria,COG1640@2|Bacteria,1MU19@1224|Proteobacteria,2TRVS@28211|Alphaproteobacteria,3JR1B@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Belongs to the glycosyl hydrolase 13 family	-	-	3.2.1.196	ko:K02438	ko00500,ko01100,map00500,map01100	-	R02111	-	ko00000,ko00001,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48,Glyco_hydro_77
HKD3_k127_3954964_11	1157708.KB907453_gene4278	8.876e-108	351.0	2BZ0R@1|root,2Z7U0@2|Bacteria,1MX37@1224|Proteobacteria,2VN75@28216|Betaproteobacteria,4AH58@80864|Comamonadaceae	28216|Betaproteobacteria	E	Nitrile hydratase, alpha chain	nthA	-	4.2.1.84	ko:K01721	ko00364,ko00380,ko00627,ko00643,ko01120,map00364,map00380,map00627,map00643,map01120	-	R02828,R04020,R05379,R05596,R07780,R07854	RC00483,RC00792,RC01345,RC01432	ko00000,ko00001,ko01000	-	-	-	NHase_alpha
HKD3_k127_3954964_12	595537.Varpa_1816	4.457e-83	292.0	28I45@1|root,2Z87Q@2|Bacteria,1R432@1224|Proteobacteria,2VTKQ@28216|Betaproteobacteria,4AHVD@80864|Comamonadaceae	28216|Betaproteobacteria	E	NHase catalyzes the hydration of various nitrile compounds to the corresponding amides	-	-	4.2.1.84	ko:K20807	ko00364,ko00380,ko00627,ko00643,ko01120,map00364,map00380,map00627,map00643,map01120	-	R04020,R05379,R05596,R07780,R07854	RC00483,RC01345,RC01432	ko00000,ko00001,ko01000	-	-	-	NHase_beta
HKD3_k127_3954964_17	595537.Varpa_1817	1.804e-50	192.0	2E3CR@1|root,32YC0@2|Bacteria,1N9Q9@1224|Proteobacteria,2VVMK@28216|Betaproteobacteria,4AIFJ@80864|Comamonadaceae	28216|Betaproteobacteria	S	Nitrile hydratase beta subunit	-	-	-	-	-	-	-	-	-	-	-	-	DUF3293,NHase_beta
HKD3_k127_3954964_5	29581.BW37_03022	1.346e-220	700.0	COG1164@1|root,COG1164@2|Bacteria,1MXAC@1224|Proteobacteria	1224|Proteobacteria	E	oligoendopeptidase F	pepF	-	-	ko:K08602	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3,Peptidase_M3_N
HKD3_k127_3954964_9	983917.RGE_46790	8.959e-147	497.0	COG4166@1|root,COG4166@2|Bacteria,1R87R@1224|Proteobacteria,2VKFJ@28216|Betaproteobacteria,1KKIK@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	ABC-type dipeptide transport system, periplasmic component	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_5
HKD3_k127_3954964_15	292415.Tbd_2170	1.885e-72	253.0	COG1180@1|root,COG1180@2|Bacteria,1NQC1@1224|Proteobacteria,2VQMN@28216|Betaproteobacteria,1KSHY@119069|Hydrogenophilales	119069|Hydrogenophilales	O	4Fe-4S single cluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM
HKD3_k127_3954964_21	1123367.C666_09125	3.924e-22	98.0	COG1328@1|root,COG1328@2|Bacteria,1N8MB@1224|Proteobacteria,2VW43@28216|Betaproteobacteria	28216|Betaproteobacteria	F	Anaerobic ribonucleoside-triphosphate reductase	-	-	-	-	-	-	-	-	-	-	-	-	NRDD
HKD3_k127_3954964_3	1268622.AVS7_02967	0.0	1121.0	COG1328@1|root,COG1328@2|Bacteria,1MWMS@1224|Proteobacteria,2VJYM@28216|Betaproteobacteria,4ABIQ@80864|Comamonadaceae	28216|Betaproteobacteria	F	Ribonucleoside-triphosphate reductase	nrdD	-	1.1.98.6	ko:K21636	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R11633,R11634,R11635,R11636	RC00613	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-cone,NRDD
HKD3_k127_3954964_18	69328.PVLB_14785	1.392e-39	154.0	COG2847@1|root,COG2847@2|Bacteria,1MZ3M@1224|Proteobacteria,1SCJD@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	protein conserved in bacteria	-	-	-	ko:K09796	-	-	-	-	ko00000,ko03110	-	-	-	PCuAC
HKD3_k127_3954964_19	748247.AZKH_4168	4.802e-39	163.0	COG3735@1|root,COG3735@2|Bacteria,1RBFT@1224|Proteobacteria,2VTX0@28216|Betaproteobacteria	28216|Betaproteobacteria	S	TraB family	-	-	-	ko:K09973	-	-	-	-	ko00000	-	-	-	TraB
HKD3_k127_3954964_14	331869.BAL199_05439	2.188e-73	258.0	COG3791@1|root,COG3791@2|Bacteria,1RFBP@1224|Proteobacteria,2U7YA@28211|Alphaproteobacteria,4BQZ3@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Glutathione-dependent formaldehyde-activating enzyme	-	-	-	-	-	-	-	-	-	-	-	-	GFA
HKD3_k127_3954964_4	1382306.JNIM01000001_gene1561	0.0	1089.0	COG0793@1|root,COG4946@1|root,COG0793@2|Bacteria,COG4946@2|Bacteria,2G64C@200795|Chloroflexi	200795|Chloroflexi	M	Tricorn protease homolog	-	-	-	ko:K08676	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PD40,Peptidase_S41,Tricorn_C1,Tricorn_PDZ
HKD3_k127_3961878_14	1197906.CAJQ02000053_gene4320	1.439e-11	76.0	COG1079@1|root,COG1079@2|Bacteria,1MVDQ@1224|Proteobacteria,2TSGJ@28211|Alphaproteobacteria,3JRUB@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Branched-chain amino acid transport system / permease component	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
HKD3_k127_3961878_4	1123256.KB907952_gene3164	1.188e-145	469.0	COG4603@1|root,COG4603@2|Bacteria,1MX6V@1224|Proteobacteria,1RS4S@1236|Gammaproteobacteria,1X9AR@135614|Xanthomonadales	135614|Xanthomonadales	S	Branched-chain amino acid transport system / permease component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_2
HKD3_k127_3961878_1	497321.C664_16935	3.224e-210	672.0	COG3845@1|root,COG3845@2|Bacteria,1NT0H@1224|Proteobacteria,2WGJY@28216|Betaproteobacteria,2KUT1@206389|Rhodocyclales	206389|Rhodocyclales	S	transport systems, ATPase components	-	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
HKD3_k127_3961878_8	305700.B447_06892	3.638e-70	267.0	COG1975@1|root,COG1975@2|Bacteria,1R3RT@1224|Proteobacteria,2VQKX@28216|Betaproteobacteria,2KWUR@206389|Rhodocyclales	206389|Rhodocyclales	O	COG1975 Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family	-	-	-	ko:K07402	-	-	-	-	ko00000	-	-	-	XdhC_C,XdhC_CoxI
HKD3_k127_3961878_0	1123256.KB907952_gene3167	9.23e-297	955.0	COG4631@1|root,COG4631@2|Bacteria,1NQSR@1224|Proteobacteria,1T1HI@1236|Gammaproteobacteria,1XDE8@135614|Xanthomonadales	135614|Xanthomonadales	F	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
HKD3_k127_3961878_3	1229205.BUPH_03242	2.112e-157	511.0	COG4630@1|root,COG4630@2|Bacteria,1MWI1@1224|Proteobacteria,2VI0J@28216|Betaproteobacteria,1K1BZ@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Xanthine dehydrogenase small subunit	xdhA	-	1.17.1.4	ko:K13481	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103	RC00143	ko00000,ko00001,ko00002,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5,Fer2,Fer2_2
HKD3_k127_3961878_11	243233.MCA0638	1.142e-49	186.0	COG2930@1|root,COG2930@2|Bacteria,1RHV6@1224|Proteobacteria,1SDNN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Las17-binding protein actin regulator	-	-	-	-	-	-	-	-	-	-	-	-	Ysc84
HKD3_k127_3961878_10	631362.Thi970DRAFT_01420	2.855e-61	224.0	COG0834@1|root,COG0834@2|Bacteria,1MV5D@1224|Proteobacteria,1RPBX@1236|Gammaproteobacteria	1236|Gammaproteobacteria	ET	ABC-type amino acid transport signal transduction systems periplasmic component domain	gltI	GO:0003333,GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0006820,GO:0006835,GO:0006836,GO:0006855,GO:0006865,GO:0008150,GO:0015711,GO:0015740,GO:0015800,GO:0015807,GO:0015813,GO:0015849,GO:0015893,GO:0016595,GO:0016597,GO:0030288,GO:0030313,GO:0031406,GO:0031975,GO:0034220,GO:0036094,GO:0042221,GO:0042493,GO:0042597,GO:0043167,GO:0043168,GO:0043177,GO:0044464,GO:0046942,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0070335,GO:0070778,GO:0071702,GO:0071705,GO:0098656,GO:1902475,GO:1903825,GO:1905039	-	ko:K10001	ko02010,ko02020,map02010,map02020	M00230	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3.19,3.A.1.3.4	-	iECH74115_1262.ECH74115_0748,iECSE_1348.ECSE_0725,iECSP_1301.ECSP_0707,iECW_1372.ECW_m0710,iECs_1301.ECs0694,iEKO11_1354.EKO11_3211,iG2583_1286.G2583_0819,iSFV_1184.SFV_0671,iSF_1195.SF0626,iS_1188.S0648,iWFL_1372.ECW_m0710,iZ_1308.Z0805	SBP_bac_3
HKD3_k127_3961878_9	631362.Thi970DRAFT_01420	4.706e-63	226.0	COG0834@1|root,COG0834@2|Bacteria,1MV5D@1224|Proteobacteria,1RPBX@1236|Gammaproteobacteria	1236|Gammaproteobacteria	ET	ABC-type amino acid transport signal transduction systems periplasmic component domain	gltI	GO:0003333,GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0006820,GO:0006835,GO:0006836,GO:0006855,GO:0006865,GO:0008150,GO:0015711,GO:0015740,GO:0015800,GO:0015807,GO:0015813,GO:0015849,GO:0015893,GO:0016595,GO:0016597,GO:0030288,GO:0030313,GO:0031406,GO:0031975,GO:0034220,GO:0036094,GO:0042221,GO:0042493,GO:0042597,GO:0043167,GO:0043168,GO:0043177,GO:0044464,GO:0046942,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0070335,GO:0070778,GO:0071702,GO:0071705,GO:0098656,GO:1902475,GO:1903825,GO:1905039	-	ko:K10001	ko02010,ko02020,map02010,map02020	M00230	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3.19,3.A.1.3.4	-	iECH74115_1262.ECH74115_0748,iECSE_1348.ECSE_0725,iECSP_1301.ECSP_0707,iECW_1372.ECW_m0710,iECs_1301.ECs0694,iEKO11_1354.EKO11_3211,iG2583_1286.G2583_0819,iSFV_1184.SFV_0671,iSF_1195.SF0626,iS_1188.S0648,iWFL_1372.ECW_m0710,iZ_1308.Z0805	SBP_bac_3
HKD3_k127_3961878_15	1000565.METUNv1_02630	1.443e-08	63.0	COG3133@1|root,COG3133@2|Bacteria,1RK6D@1224|Proteobacteria,2VU04@28216|Betaproteobacteria,2KWUY@206389|Rhodocyclales	206389|Rhodocyclales	M	Glycine zipper 2TM domain	-	-	-	-	-	-	-	-	-	-	-	-	Rick_17kDa_Anti
HKD3_k127_3961878_5	396588.Tgr7_1494	4.095e-110	367.0	COG0767@1|root,COG0767@2|Bacteria,1MVPN@1224|Proteobacteria,1S0WJ@1236|Gammaproteobacteria,1WWFB@135613|Chromatiales	135613|Chromatiales	Q	Permease MlaE	-	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE,STAS_2
HKD3_k127_3961878_6	1121447.JONL01000001_gene680	2.123e-91	307.0	COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,42NTG@68525|delta/epsilon subdivisions,2WKHW@28221|Deltaproteobacteria,2M8FK@213115|Desulfovibrionales	28221|Deltaproteobacteria	Q	PFAM ABC transporter related	-	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
HKD3_k127_3961878_7	1120999.JONM01000019_gene3409	1.42e-75	266.0	COG1463@1|root,COG1463@2|Bacteria,1MYEF@1224|Proteobacteria	1224|Proteobacteria	Q	Mammalian cell entry related domain protein	-	-	-	ko:K02067,ko:K06192	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaD
HKD3_k127_3961878_13	1121447.JONL01000001_gene678	4.956e-15	89.0	COG3009@1|root,COG3009@2|Bacteria,1N9IG@1224|Proteobacteria,42VAV@68525|delta/epsilon subdivisions,2WS0E@28221|Deltaproteobacteria,2MBBH@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	ABC-type transport auxiliary lipoprotein component	-	-	-	ko:K18480	-	M00669	-	-	ko00000,ko00002,ko02000	3.A.1.27.1	-	-	ABC_trans_aux
HKD3_k127_3961878_2	335543.Sfum_1077	6.048e-175	564.0	COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,42NKZ@68525|delta/epsilon subdivisions,2WK44@28221|Deltaproteobacteria,2MQ56@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	TIGRFAM RND efflux system, outer membrane lipoprotein, NodT	-	-	-	ko:K18139	ko01501,ko02024,map01501,map02024	M00642,M00643,M00647,M00718,M00768,M00822	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	1.B.17,2.A.6.2	-	-	MFS_1,OEP
HKD3_k127_3961878_12	522306.CAP2UW1_0166	6.433e-21	93.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHFI@28216|Betaproteobacteria,1KQBT@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	U	TIGRFAM transporter, hydrophobe amphiphile efflux-1 (HAE1) family	-	-	-	ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
HKD3_k127_3968560_11	1297863.APJF01000001_gene2156	1.084e-34	139.0	COG2095@1|root,COG2095@2|Bacteria,1MX5T@1224|Proteobacteria,2VA2I@28211|Alphaproteobacteria,3JYVQ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	U	MarC family integral membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	MarC
HKD3_k127_3968560_9	1485544.JQKP01000001_gene1245	4.096e-83	286.0	COG0566@1|root,COG0566@2|Bacteria,1MWCM@1224|Proteobacteria,2VHF4@28216|Betaproteobacteria,44VAT@713636|Nitrosomonadales	28216|Betaproteobacteria	J	Specifically methylates the ribose of guanosine 2251 in 23S rRNA	rlmB	-	2.1.1.185	ko:K03218	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SpoU_methylase,SpoU_sub_bind
HKD3_k127_3968560_3	1100721.ALKO01000017_gene1794	7.062e-143	461.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2VHEF@28216|Betaproteobacteria,4ABQ2@80864|Comamonadaceae	28216|Betaproteobacteria	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
HKD3_k127_3968560_2	1265502.KB905948_gene995	4.092e-161	529.0	COG1473@1|root,COG1473@2|Bacteria,1MUIV@1224|Proteobacteria,2VM4Z@28216|Betaproteobacteria,4ABJ2@80864|Comamonadaceae	28216|Betaproteobacteria	S	peptidase dimerisation domain protein	yxeP_2	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
HKD3_k127_3968560_6	257310.BB4026	6.674e-134	433.0	COG1173@1|root,COG1173@2|Bacteria,1MUG0@1224|Proteobacteria,2VIN2@28216|Betaproteobacteria,3T1KQ@506|Alcaligenaceae	28216|Betaproteobacteria	P	ABC-type dipeptide oligopeptide nickel transport systems, permease components	dppC	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
HKD3_k127_3968560_4	1380394.JADL01000008_gene3544	1.516e-138	467.0	COG0444@1|root,COG0444@2|Bacteria,1R4KB@1224|Proteobacteria,2TR0J@28211|Alphaproteobacteria,2JP9V@204441|Rhodospirillales	204441|Rhodospirillales	EP	Belongs to the ABC transporter superfamily	oppD	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
HKD3_k127_3968560_5	511.JT27_04850	1.372e-137	449.0	COG4608@1|root,COG4608@2|Bacteria,1NU4K@1224|Proteobacteria,2W19X@28216|Betaproteobacteria,3T267@506|Alcaligenaceae	28216|Betaproteobacteria	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02032,ko:K12372	ko02010,ko02024,map02010,map02024	M00239,M00324	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
HKD3_k127_3968560_0	94624.Bpet1704	5.262e-297	949.0	COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,2VJMF@28216|Betaproteobacteria,3T1XY@506|Alcaligenaceae	28216|Betaproteobacteria	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
HKD3_k127_3968560_10	261292.Nit79A3_1796	3.614e-59	220.0	COG3115@1|root,COG3115@2|Bacteria,1NJ6D@1224|Proteobacteria,2VHQ7@28216|Betaproteobacteria,372FG@32003|Nitrosomonadales	28216|Betaproteobacteria	D	Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins	zipA	-	-	-	-	-	-	-	-	-	-	-	ZipA_C
HKD3_k127_3968560_1	342113.DM82_1748	1.531e-264	839.0	COG0272@1|root,COG0272@2|Bacteria,1MV3R@1224|Proteobacteria,2VIDE@28216|Betaproteobacteria,1K0GW@119060|Burkholderiaceae	28216|Betaproteobacteria	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	-	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5
HKD3_k127_3968560_7	159087.Daro_1735	7.262e-117	383.0	COG1210@1|root,COG1210@2|Bacteria,1MV5F@1224|Proteobacteria,2VH00@28216|Betaproteobacteria,2KUS0@206389|Rhodocyclales	206389|Rhodocyclales	M	UTP-glucose-1-phosphate uridylyltransferase	epsT	-	2.7.7.9	ko:K00963	ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130	M00129,M00361,M00362,M00549	R00289	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
HKD3_k127_3968560_8	580332.Slit_0301	1.324e-109	366.0	COG0583@1|root,COG0583@2|Bacteria,1MVA1@1224|Proteobacteria,2VIBJ@28216|Betaproteobacteria,44WDP@713636|Nitrosomonadales	28216|Betaproteobacteria	K	Transcriptional regulator, LysR family	oxyR	-	-	ko:K04761	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_1,LysR_substrate
HKD3_k127_4042207_0	420662.Mpe_A3264	1.791e-169	539.0	COG2759@1|root,COG2759@2|Bacteria,1MUR8@1224|Proteobacteria,2VKR6@28216|Betaproteobacteria,1KIXT@119065|unclassified Burkholderiales	28216|Betaproteobacteria	F	Formate--tetrahydrofolate ligase	fhs	-	6.3.4.3	ko:K01938	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R00943	RC00026,RC00111	ko00000,ko00001,ko00002,ko01000	-	-	-	FTHFS
HKD3_k127_4042207_4	388051.AUFE01000052_gene272	1.904e-45	184.0	COG3663@1|root,COG3663@2|Bacteria,1REPV@1224|Proteobacteria,2VRAT@28216|Betaproteobacteria,1K7EX@119060|Burkholderiaceae	28216|Betaproteobacteria	L	glycosylase	mug	-	3.2.2.28	ko:K03649	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
HKD3_k127_4042207_2	196367.JNFG01000006_gene6980	1.467e-111	368.0	COG0382@1|root,COG0382@2|Bacteria,1MV4Q@1224|Proteobacteria,2VHEU@28216|Betaproteobacteria,1K3QR@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate	ubiA	-	2.5.1.39	ko:K03179	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R05000,R05615	RC00209,RC02895	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
HKD3_k127_4042207_3	305700.B447_11522	1.614e-91	327.0	COG0451@1|root,COG0451@2|Bacteria,1MWVJ@1224|Proteobacteria,2VJ3T@28216|Betaproteobacteria,2KUSE@206389|Rhodocyclales	206389|Rhodocyclales	GM	epimerase dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase,NAD_binding_10
HKD3_k127_4042207_1	1123392.AQWL01000006_gene692	2.236e-145	484.0	COG0543@1|root,COG0633@1|root,COG0543@2|Bacteria,COG0633@2|Bacteria,1MV72@1224|Proteobacteria,2VI9K@28216|Betaproteobacteria,1KRC9@119069|Hydrogenophilales	119069|Hydrogenophilales	CH	Oxidoreductase FAD-binding domain	-	-	1.17.1.1	ko:K00523	ko00520,map00520	-	R03391,R03392	RC00230	ko00000,ko00001,ko01000	-	-	-	FAD_binding_6,Fer2,NAD_binding_1
HKD3_k127_4042207_5	305900.GV64_06415	1.294e-19	91.0	COG3205@1|root,COG3205@2|Bacteria,1N85D@1224|Proteobacteria,1SCCN@1236|Gammaproteobacteria,1XM6R@135619|Oceanospirillales	135619|Oceanospirillales	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF2061
HKD3_k127_4046778_1	204773.HEAR1105	7.293e-49	194.0	COG2062@1|root,COG2062@2|Bacteria,1RIVH@1224|Proteobacteria,2VSSQ@28216|Betaproteobacteria,4741H@75682|Oxalobacteraceae	28216|Betaproteobacteria	T	phosphohistidine phosphatase	sixA	-	-	ko:K08296	-	-	-	-	ko00000,ko01000	-	-	-	His_Phos_1
HKD3_k127_4046778_0	1005048.CFU_2515	9.991e-147	474.0	COG0855@1|root,COG0855@2|Bacteria,1MUM3@1224|Proteobacteria,2VHH8@28216|Betaproteobacteria,47310@75682|Oxalobacteraceae	28216|Betaproteobacteria	H	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)	ppk	-	2.7.4.1	ko:K00937	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PP_kinase,PP_kinase_C,PP_kinase_N
HKD3_k127_4059292_12	1348657.M622_09140	5.42e-29	128.0	COG3235@1|root,COG3235@2|Bacteria,1RDHR@1224|Proteobacteria,2VRKF@28216|Betaproteobacteria,2KWF3@206389|Rhodocyclales	206389|Rhodocyclales	S	Cobalt uptake substrate-specific transmembrane region	-	-	-	-	-	-	-	-	-	-	-	-	CbiM
HKD3_k127_4059292_5	580332.Slit_1498	3.037e-63	224.0	COG0664@1|root,COG0664@2|Bacteria,1R6BV@1224|Proteobacteria,2VN3A@28216|Betaproteobacteria,44VNG@713636|Nitrosomonadales	28216|Betaproteobacteria	K	helix_turn_helix, cAMP Regulatory protein	nnr	-	-	ko:K01420	-	-	-	-	ko00000,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
HKD3_k127_4059292_7	395495.Lcho_1209	4.541e-46	178.0	COG3945@1|root,COG3945@2|Bacteria,1N12K@1224|Proteobacteria,2VUPY@28216|Betaproteobacteria,1KKSC@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	PFAM Hemerythrin HHE cation binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
HKD3_k127_4059292_13	987059.RBXJA2T_14501	1.141e-20	99.0	COG3094@1|root,COG3094@2|Bacteria,1NPTP@1224|Proteobacteria,2VWBN@28216|Betaproteobacteria,1KMPT@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Invasion gene expression up-regulator, SirB	-	-	-	-	-	-	-	-	-	-	-	-	SirB
HKD3_k127_4059292_8	1485544.JQKP01000003_gene98	1.163e-45	170.0	COG3945@1|root,COG3945@2|Bacteria,1N0BD@1224|Proteobacteria,2VUY4@28216|Betaproteobacteria,44WHW@713636|Nitrosomonadales	28216|Betaproteobacteria	S	Hemerythrin HHE cation binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
HKD3_k127_4059292_1	1121035.AUCH01000001_gene2080	2.056e-182	583.0	COG0635@1|root,COG0635@2|Bacteria,1MV1I@1224|Proteobacteria,2VJ1F@28216|Betaproteobacteria,2KVK4@206389|Rhodocyclales	206389|Rhodocyclales	H	Belongs to the anaerobic coproporphyrinogen-III oxidase family	-	-	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
HKD3_k127_4059292_3	748247.AZKH_2150	1.721e-108	356.0	COG1028@1|root,COG1028@2|Bacteria,1N907@1224|Proteobacteria,2VJ81@28216|Betaproteobacteria,2KYAR@206389|Rhodocyclales	206389|Rhodocyclales	IQ	KR domain	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HKD3_k127_4059292_11	648757.Rvan_0042	5.098e-38	151.0	COG1959@1|root,COG1959@2|Bacteria,1PZ79@1224|Proteobacteria,2UCUA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Rrf2
HKD3_k127_4059292_10	648757.Rvan_0043	7.973e-41	160.0	COG0454@1|root,COG0456@2|Bacteria,1N43K@1224|Proteobacteria,2UDB6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HKD3_k127_4059292_9	1380394.JADL01000002_gene1592	9.471e-44	168.0	COG5496@1|root,COG5496@2|Bacteria,1RKFT@1224|Proteobacteria,2U5DE@28211|Alphaproteobacteria,2JUEU@204441|Rhodospirillales	204441|Rhodospirillales	S	Thioesterase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_4059292_0	85643.Tmz1t_2959	0.0	1262.0	COG0243@1|root,COG0243@2|Bacteria,1P01N@1224|Proteobacteria,2VMWP@28216|Betaproteobacteria,2KVYZ@206389|Rhodocyclales	206389|Rhodocyclales	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	1.17.5.1,3.1.2.25	ko:K18361	ko00360,map00360	-	R07222,R07294	RC00004,RC01844,RC01903	ko00000,ko00001,ko01000	-	-	-	Molybdopterin,Molydop_binding
HKD3_k127_4059292_4	85643.Tmz1t_2960	7.814e-98	357.0	COG0437@1|root,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,2VKVM@28216|Betaproteobacteria,2KXUS@206389|Rhodocyclales	206389|Rhodocyclales	C	4Fe-4S binding domain	-	-	-	ko:K18362	ko00360,map00360	-	R07222,R07294	RC00004,RC01844,RC01903	ko00000,ko00001	-	-	-	-
HKD3_k127_4059292_6	62928.azo1948	2.129e-51	202.0	COG3302@1|root,COG3302@2|Bacteria,1N8SU@1224|Proteobacteria,2WGE7@28216|Betaproteobacteria,2M04N@206389|Rhodocyclales	206389|Rhodocyclales	S	DMSO reductase anchor subunit (DmsC)	-	-	-	ko:K18363	ko00360,map00360	-	R07222,R07294	RC00004,RC01844,RC01903	ko00000,ko00001	-	-	-	DmsC
HKD3_k127_4059292_2	1150469.RSPPHO_01412	3.93e-122	399.0	COG1541@1|root,COG1541@2|Bacteria,1MV1W@1224|Proteobacteria,2TRVF@28211|Alphaproteobacteria,2JQ5N@204441|Rhodospirillales	204441|Rhodospirillales	H	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)	-	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C_2
HKD3_k127_4059882_3	375286.mma_1247	5.551e-180	572.0	COG1448@1|root,COG1448@2|Bacteria,1MUT0@1224|Proteobacteria,2VHNH@28216|Betaproteobacteria,472KW@75682|Oxalobacteraceae	28216|Betaproteobacteria	E	Aminotransferase class I and II	tyrB	-	2.6.1.57	ko:K00832	ko00270,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01230,map00270,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01230	M00024,M00025,M00034,M00040	R00694,R00734,R01731,R07396,R10845	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
HKD3_k127_4059882_2	1121033.AUCF01000001_gene2306	3.616e-234	739.0	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2TQMR@28211|Alphaproteobacteria,2JQAX@204441|Rhodospirillales	204441|Rhodospirillales	V	ABC-type multidrug transport system, ATPase and permease	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
HKD3_k127_4059882_0	640081.Dsui_2434	0.0	1043.0	COG0556@1|root,COG0556@2|Bacteria,1MUFK@1224|Proteobacteria,2VHFQ@28216|Betaproteobacteria,2KVUA@206389|Rhodocyclales	206389|Rhodocyclales	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	-	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
HKD3_k127_4059882_4	983917.RGE_46790	4.256e-140	468.0	COG4166@1|root,COG4166@2|Bacteria,1R87R@1224|Proteobacteria,2VKFJ@28216|Betaproteobacteria,1KKIK@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	ABC-type dipeptide transport system, periplasmic component	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_5
HKD3_k127_4059882_6	322710.Avin_14790	1.75e-58	207.0	COG0394@1|root,COG0394@2|Bacteria,1RH90@1224|Proteobacteria,1S5X6@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Belongs to the low molecular weight phosphotyrosine protein phosphatase family	ptpA	-	3.1.3.48	ko:K01104	-	-	-	-	ko00000,ko01000	-	-	-	LMWPc
HKD3_k127_4059882_1	1236959.BAMT01000001_gene1751	5.181e-261	834.0	COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,2VIE5@28216|Betaproteobacteria,2KKR7@206350|Nitrosomonadales	206350|Nitrosomonadales	J	Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs	rne	-	3.1.26.12	ko:K08300	ko03018,map03018	M00394	-	-	ko00000,ko00001,ko00002,ko01000,ko03009,ko03019	-	-	-	RNase_E_G,S1
HKD3_k127_4059882_5	1163617.SCD_n01546	2.121e-110	368.0	COG0564@1|root,COG0564@2|Bacteria,1MVDX@1224|Proteobacteria,2VI51@28216|Betaproteobacteria	28216|Betaproteobacteria	J	Responsible for synthesis of pseudouridine from uracil	rluC	-	5.4.99.24	ko:K06179	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
HKD3_k127_4124782_12	1163617.SCD_n00281	8.81e-59	224.0	2A8Z1@1|root,30Y2U@2|Bacteria,1PJYG@1224|Proteobacteria,2VJ83@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_4124782_1	1123392.AQWL01000006_gene548	3.491e-238	755.0	COG1331@1|root,COG1331@2|Bacteria,1MUUT@1224|Proteobacteria,2VKKI@28216|Betaproteobacteria,1KS50@119069|Hydrogenophilales	119069|Hydrogenophilales	O	Protein of unknown function, DUF255	-	-	-	-	-	-	-	-	-	-	-	-	Thioredox_DsbH
HKD3_k127_4124782_19	279714.FuraDRAFT_3349	2.846e-27	117.0	COG4654@1|root,COG4654@2|Bacteria,1N6UN@1224|Proteobacteria,2VW1Y@28216|Betaproteobacteria,2KRVU@206351|Neisseriales	206351|Neisseriales	C	Cytochrome c	-	-	-	ko:K08738	ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	3.D.4.6	-	-	Cytochrom_C,Cytochrome_CBB3
HKD3_k127_4124782_4	580332.Slit_2859	4.302e-157	507.0	COG0404@1|root,COG0404@2|Bacteria,1MV96@1224|Proteobacteria,2VIT9@28216|Betaproteobacteria,44VKF@713636|Nitrosomonadales	28216|Betaproteobacteria	E	The glycine cleavage system catalyzes the degradation of glycine	gcvT	GO:0001505,GO:0003674,GO:0003824,GO:0004047,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006544,GO:0006546,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0009056,GO:0009063,GO:0009069,GO:0009071,GO:0009987,GO:0016054,GO:0016740,GO:0016741,GO:0017144,GO:0019464,GO:0019752,GO:0032259,GO:0042133,GO:0042135,GO:0042737,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	GCV_T,GCV_T_C
HKD3_k127_4124782_17	216595.PFLU_1117	4.623e-30	130.0	COG1247@1|root,COG1247@2|Bacteria,1N8HA@1224|Proteobacteria,1T34K@1236|Gammaproteobacteria,1YUHN@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	M	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Methyltransf_25
HKD3_k127_4124782_15	748247.AZKH_2239	1.626e-51	185.0	COG0509@1|root,COG0509@2|Bacteria,1RGV7@1224|Proteobacteria,2VSD7@28216|Betaproteobacteria,2KWQ0@206389|Rhodocyclales	206389|Rhodocyclales	E	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	gcvH	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
HKD3_k127_4124782_0	264198.Reut_A3331	0.0	1349.0	COG0403@1|root,COG1003@1|root,COG0403@2|Bacteria,COG1003@2|Bacteria,1MUDP@1224|Proteobacteria,2VHQ6@28216|Betaproteobacteria,1K105@119060|Burkholderiaceae	28216|Betaproteobacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvP	-	1.4.4.2	ko:K00281	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko00002,ko01000	-	-	-	GDC-P
HKD3_k127_4124782_5	864051.BurJ1DRAFT_4026	5.487e-148	481.0	COG0665@1|root,COG0665@2|Bacteria,1MVIZ@1224|Proteobacteria,2VH1D@28216|Betaproteobacteria,1KJ8N@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	D-amino acid	dad2	-	1.4.5.1	ko:K00285	ko00360,map00360	-	R01374,R09493	RC00006,RC00025	ko00000,ko00001,ko01000	-	-	-	DAO,FAD_binding_2
HKD3_k127_4124782_20	861299.J421_0250	4.277e-22	113.0	2C802@1|root,332EH@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440
HKD3_k127_4124782_7	1288494.EBAPG3_23040	7.69e-134	449.0	COG1686@1|root,COG1686@2|Bacteria,1MUU7@1224|Proteobacteria,2VH46@28216|Betaproteobacteria,3721U@32003|Nitrosomonadales	28216|Betaproteobacteria	M	Belongs to the peptidase S11 family	dacC	-	3.4.16.4	ko:K01286,ko:K07258	ko00550,ko01100,map00550,map01100	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	PBP5_C,Peptidase_S11
HKD3_k127_4124782_9	1163617.SCD_n00104	7.495e-114	377.0	COG0115@1|root,COG0115@2|Bacteria,1MVAT@1224|Proteobacteria,2VIVK@28216|Betaproteobacteria	28216|Betaproteobacteria	EH	Aminotransferase class IV	dat	-	2.6.1.21	ko:K00824	ko00310,ko00330,ko00360,ko00472,ko00473,ko01100,map00310,map00330,map00360,map00472,map00473,map01100	-	R01148,R01582,R02459,R02851,R02924,R05053	RC00006,RC00008,RC00025	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_4
HKD3_k127_4124782_16	204773.HEAR2604	2.536e-48	179.0	COG1853@1|root,COG1853@2|Bacteria,1RDM1@1224|Proteobacteria,2VRFI@28216|Betaproteobacteria,474R7@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Conserved protein of DIM6 NTAB family	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
HKD3_k127_4124782_6	1123393.KB891327_gene347	7.197e-134	439.0	COG2230@1|root,COG2230@2|Bacteria,1MX3U@1224|Proteobacteria,2VIPR@28216|Betaproteobacteria,1KSEY@119069|Hydrogenophilales	119069|Hydrogenophilales	M	Mycolic acid cyclopropane synthetase	-	-	-	-	-	-	-	-	-	-	-	-	CMAS
HKD3_k127_4124782_18	1123487.KB892834_gene2779	2.065e-29	120.0	COG2921@1|root,COG2921@2|Bacteria,1RGV5@1224|Proteobacteria,2VTY5@28216|Betaproteobacteria,2KWZM@206389|Rhodocyclales	206389|Rhodocyclales	S	Belongs to the UPF0250 family	-	-	-	ko:K09158	-	-	-	-	ko00000	-	-	-	DUF493
HKD3_k127_4124782_11	1120999.JONM01000006_gene2440	1.448e-74	257.0	COG0321@1|root,COG0321@2|Bacteria,1MU6A@1224|Proteobacteria,2VQ1Y@28216|Betaproteobacteria,2KQEE@206351|Neisseriales	206351|Neisseriales	H	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate	lipB	-	2.3.1.181	ko:K03801	ko00785,ko01100,map00785,map01100	-	R07766,R07769	RC00039,RC00992,RC02867	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB
HKD3_k127_4124782_3	257313.BP0106	2.511e-157	503.0	COG0320@1|root,COG0320@2|Bacteria,1MVRD@1224|Proteobacteria,2VIFE@28216|Betaproteobacteria,3T25N@506|Alcaligenaceae	28216|Betaproteobacteria	H	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives	lipA	-	2.8.1.8	ko:K03644	ko00785,ko01100,map00785,map01100	-	R07767,R07768	RC01978	ko00000,ko00001,ko01000	-	-	-	LIAS_N,Radical_SAM
HKD3_k127_4124782_8	1304883.KI912532_gene1267	3.929e-129	423.0	COG2821@1|root,COG2821@2|Bacteria,1MXD4@1224|Proteobacteria,2VHBF@28216|Betaproteobacteria,2KV14@206389|Rhodocyclales	206389|Rhodocyclales	M	Membrane-bound lytic murein transglycosylase	mltA	-	-	ko:K08304	-	-	-	-	ko00000,ko01000,ko01011	-	GH102	-	3D,MltA
HKD3_k127_4124782_14	1123393.KB891316_gene1548	3.336e-52	187.0	COG2967@1|root,COG2967@2|Bacteria,1MZ2Z@1224|Proteobacteria,2VSPE@28216|Betaproteobacteria,1KT3H@119069|Hydrogenophilales	119069|Hydrogenophilales	P	ApaG domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF525
HKD3_k127_4124782_10	667632.KB890170_gene3629	5.316e-108	354.0	COG0036@1|root,COG0036@2|Bacteria,1MUZM@1224|Proteobacteria,2VIGU@28216|Betaproteobacteria,1K37J@119060|Burkholderiaceae	28216|Betaproteobacteria	G	Belongs to the ribulose-phosphate 3-epimerase family	rpe	-	5.1.3.1	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
HKD3_k127_4124782_13	1163617.SCD_n02534	9.839e-56	203.0	COG0546@1|root,COG0546@2|Bacteria,1RDDY@1224|Proteobacteria,2VIZ6@28216|Betaproteobacteria	28216|Betaproteobacteria	G	Phosphoglycolate phosphatase	gph	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
HKD3_k127_4124782_2	323848.Nmul_A2369	8.211e-173	555.0	COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,2VI2V@28216|Betaproteobacteria,372HF@32003|Nitrosomonadales	28216|Betaproteobacteria	H	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia	trpE	-	4.1.3.27	ko:K01657	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
HKD3_k127_4140477_1	257310.BB1362	1.094e-131	424.0	COG0343@1|root,COG0343@2|Bacteria,1MUCA@1224|Proteobacteria,2VIRX@28216|Betaproteobacteria,3T20J@506|Alcaligenaceae	28216|Betaproteobacteria	F	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)	tgt	-	2.4.2.29	ko:K00773	-	-	R03789,R10209	RC00063	ko00000,ko01000,ko03016	-	-	-	TGT
HKD3_k127_4140477_2	1000565.METUNv1_00172	2.932e-34	135.0	COG1862@1|root,COG1862@2|Bacteria,1MZT2@1224|Proteobacteria,2VU6T@28216|Betaproteobacteria,2KWNW@206389|Rhodocyclales	206389|Rhodocyclales	U	preprotein translocase subunit YajC	yajC	-	-	ko:K03210	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	YajC
HKD3_k127_4140477_0	1163617.SCD_n02208	1.719e-166	533.0	COG0342@1|root,COG0342@2|Bacteria,1MV5U@1224|Proteobacteria,2VHKD@28216|Betaproteobacteria	28216|Betaproteobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	-	-	ko:K03072	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD-TM1,SecD_SecF,Sec_GG
HKD3_k127_42602_0	580332.Slit_0396	2.386e-321	1001.0	COG3387@1|root,COG3387@2|Bacteria,1MYVI@1224|Proteobacteria,2VIRI@28216|Betaproteobacteria	28216|Betaproteobacteria	G	Glucodextranase, domain N	-	-	3.2.1.3	ko:K01178	ko00500,ko01100,map00500,map01100	-	R01790,R01791,R06199	-	ko00000,ko00001,ko01000	-	GH15	-	CBM_20,Glucodextran_N,Glyco_hydro_15
HKD3_k127_42602_5	572477.Alvin_0241	1.01e-118	396.0	COG0661@1|root,COG0661@2|Bacteria,1MW1J@1224|Proteobacteria,1RYAY@1236|Gammaproteobacteria,1WW8Z@135613|Chromatiales	135613|Chromatiales	S	pfam abc1	-	-	-	-	-	-	-	-	-	-	-	-	ABC1
HKD3_k127_42602_6	614083.AWQR01000028_gene3145	1.244e-109	363.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VHK8@28216|Betaproteobacteria,4A9R8@80864|Comamonadaceae	28216|Betaproteobacteria	S	PFAM conserved	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HKD3_k127_42602_1	1304883.KI912532_gene1783	1.433e-276	863.0	COG1894@1|root,COG1905@1|root,COG1894@2|Bacteria,COG1905@2|Bacteria,1MV8F@1224|Proteobacteria,2VHW2@28216|Betaproteobacteria,2KUYG@206389|Rhodocyclales	206389|Rhodocyclales	C	Respiratory-chain NADH dehydrogenase	hoxF	-	1.12.1.2	ko:K18005	-	-	-	-	ko00000,ko01000	-	-	-	2Fe-2S_thioredx,Complex1_51K,NADH_4Fe-4S,SLBB
HKD3_k127_42602_8	580332.Slit_1609	5.116e-105	376.0	COG1034@1|root,COG1034@2|Bacteria,1QVC7@1224|Proteobacteria,2VI6U@28216|Betaproteobacteria,44W9N@713636|Nitrosomonadales	28216|Betaproteobacteria	C	PFAM NADH ubiquinone oxidoreductase, subunit G, iron-sulphur binding	hoxU	-	1.12.1.2	ko:K18006	-	-	-	-	ko00000,ko01000	-	-	-	Fer2_4,Fer4_15,NADH-G_4Fe-4S_3
HKD3_k127_42602_9	580332.Slit_1610	8.49e-95	326.0	COG1941@1|root,COG1941@2|Bacteria,1NS0E@1224|Proteobacteria,2VJH8@28216|Betaproteobacteria,44WAW@713636|Nitrosomonadales	28216|Betaproteobacteria	C	PFAM NADH ubiquinone oxidoreductase 20 kDa subunit	hoxY	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	1.12.1.2	ko:K18007	-	-	-	-	ko00000,ko01000	-	-	-	Oxidored_q6
HKD3_k127_42602_2	497321.C664_02175	8.101e-246	767.0	COG3259@1|root,COG3259@2|Bacteria,1QUQ7@1224|Proteobacteria,2VJT0@28216|Betaproteobacteria,2KVAX@206389|Rhodocyclales	206389|Rhodocyclales	C	Belongs to the NiFe NiFeSe hydrogenase large subunit family	hoxH	-	1.12.1.2	ko:K00436	-	-	R00700	-	ko00000,ko01000	-	-	-	NiFeSe_Hases
HKD3_k127_42602_12	768671.ThimaDRAFT_4192	1.495e-36	145.0	COG0680@1|root,COG0680@2|Bacteria,1MZE1@1224|Proteobacteria,1SB0K@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	hydrogenase maturation protease	hoxW	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_42602_7	1095769.CAHF01000005_gene1582	3.014e-108	357.0	COG0179@1|root,COG0179@2|Bacteria,1MVFA@1224|Proteobacteria,2VHG8@28216|Betaproteobacteria,472KB@75682|Oxalobacteraceae	28216|Betaproteobacteria	Q	Fumarylacetoacetate (FAA) hydrolase family	-	-	3.7.1.20	ko:K16165	ko00350,ko01100,ko01120,map00350,map01100,map01120	-	R01085	RC00326,RC00446	ko00000,ko00001,ko01000	-	-	-	FAA_hydrolase
HKD3_k127_42602_3	243233.MCA2787	2.742e-127	422.0	COG0695@1|root,COG0695@2|Bacteria,1QVSK@1224|Proteobacteria,1T3G3@1236|Gammaproteobacteria,1XDZF@135618|Methylococcales	135618|Methylococcales	O	PFAM glutaredoxin	-	-	-	-	-	-	-	-	-	-	-	-	Glutaredoxin
HKD3_k127_42602_16	861299.J421_1578	1.61e-08	61.0	29A2M@1|root,2ZX40@2|Bacteria,1ZU3E@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_42602_4	1163617.SCD_n00016	1.663e-119	392.0	COG1432@1|root,COG1432@2|Bacteria,1MX5C@1224|Proteobacteria,2VK44@28216|Betaproteobacteria	28216|Betaproteobacteria	NU	NYN domain	-	-	-	-	-	-	-	-	-	-	-	-	NYN,OST-HTH
HKD3_k127_42602_13	264198.Reut_A2690	1.402e-30	126.0	COG2259@1|root,COG2259@2|Bacteria,1N1VA@1224|Proteobacteria,2VU9I@28216|Betaproteobacteria,1K6ZW@119060|Burkholderiaceae	28216|Betaproteobacteria	S	DoxX	-	-	-	ko:K15977	-	-	-	-	ko00000	-	-	-	DoxX
HKD3_k127_42602_11	1100720.ALKN01000030_gene1161	1.579e-57	203.0	COG1917@1|root,COG1917@2|Bacteria,1NNBT@1224|Proteobacteria,2VWRN@28216|Betaproteobacteria,4AJDV@80864|Comamonadaceae	28216|Betaproteobacteria	S	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_42602_17	62928.azo2153	2.172e-08	62.0	COG2847@1|root,COG2847@2|Bacteria,1MZ3M@1224|Proteobacteria,2VTY7@28216|Betaproteobacteria,2KWMU@206389|Rhodocyclales	206389|Rhodocyclales	S	Copper chaperone PCu(A)C	-	-	-	ko:K09796	-	-	-	-	ko00000,ko03110	-	-	-	PCuAC
HKD3_k127_42602_14	153948.NAL212_0192	3.223e-27	128.0	COG5549@1|root,COG5549@2|Bacteria,1PE84@1224|Proteobacteria,2WC16@28216|Betaproteobacteria,37458@32003|Nitrosomonadales	28216|Betaproteobacteria	O	protein import	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_42602_15	1123073.KB899241_gene1867	7.471e-10	72.0	COG3391@1|root,COG3391@2|Bacteria,1R7H9@1224|Proteobacteria,1SGRP@1236|Gammaproteobacteria,1X57E@135614|Xanthomonadales	135614|Xanthomonadales	S	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	Lactonase
HKD3_k127_4356971_3	62928.azo2921	4.851e-35	137.0	COG0315@1|root,COG0315@2|Bacteria,1RCYZ@1224|Proteobacteria,2VR7B@28216|Betaproteobacteria,2KW2Z@206389|Rhodocyclales	206389|Rhodocyclales	H	Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)	moaC	-	4.6.1.17	ko:K03637	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R11372	RC03425	ko00000,ko00001,ko01000	-	-	-	MoaC
HKD3_k127_4356971_0	1163617.SCD_n00796	2.319e-128	434.0	COG4783@1|root,COG4783@2|Bacteria,1MVFV@1224|Proteobacteria,2VHAY@28216|Betaproteobacteria	28216|Betaproteobacteria	S	peptidase m48, ste24p	yggG_1	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48,TPR_19
HKD3_k127_4356971_1	795666.MW7_0758	9.256e-117	399.0	COG0845@1|root,COG0845@2|Bacteria,1MU8D@1224|Proteobacteria,2VH9K@28216|Betaproteobacteria,1K50V@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K02005,ko:K13888	-	M00709	-	-	ko00000,ko00002,ko02000	8.A.1	-	-	HlyD_D23
HKD3_k127_4356971_2	795666.MW7_0759	5.556e-74	255.0	COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,2VIKP@28216|Betaproteobacteria,1K47S@119060|Burkholderiaceae	28216|Betaproteobacteria	V	abc transporter	macB	-	-	ko:K02003,ko:K05685	ko02010,map02010	M00258,M00709	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.122.1,3.A.1.122.12	-	-	ABC_tran,FtsX,MacB_PCD
HKD3_k127_43600_0	556268.OFAG_01921	2.016e-118	400.0	COG4166@1|root,COG4166@2|Bacteria,1R87R@1224|Proteobacteria,2VKFJ@28216|Betaproteobacteria,476HH@75682|Oxalobacteraceae	28216|Betaproteobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_5
HKD3_k127_4413643_2	375286.mma_2405	5.997e-20	92.0	COG3064@1|root,COG3064@2|Bacteria,1MXPS@1224|Proteobacteria,2VKTY@28216|Betaproteobacteria,474N0@75682|Oxalobacteraceae	28216|Betaproteobacteria	M	Protein of unknown function (DUF3300)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3300
HKD3_k127_4413643_1	634497.HAH_2430	5.939e-52	195.0	COG1296@1|root,arCOG04452@2157|Archaea,2XWP8@28890|Euryarchaeota,23VF2@183963|Halobacteria	183963|Halobacteria	E	branched-chain amino acid permease (azaleucine resistance)	azlC	-	-	-	-	-	-	-	-	-	-	-	AzlC
HKD3_k127_4413643_3	1231392.OCGS_2073	2.432e-07	63.0	COG4392@1|root,COG4392@2|Bacteria,1MZUZ@1224|Proteobacteria,2UC31@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	AzlD
HKD3_k127_4413643_0	748247.AZKH_1791	2.081e-116	378.0	COG0714@1|root,COG0714@2|Bacteria,1MV5I@1224|Proteobacteria,2VH9H@28216|Betaproteobacteria,2KVTW@206389|Rhodocyclales	206389|Rhodocyclales	O	ATPase (AAA	-	-	-	-	-	-	-	-	-	-	-	-	AAA,AAA_5
HKD3_k127_4439051_2	323848.Nmul_A2083	1.15e-186	591.0	COG0008@1|root,COG0008@2|Bacteria,1MUC8@1224|Proteobacteria,2VHZX@28216|Betaproteobacteria,3724J@32003|Nitrosomonadales	28216|Betaproteobacteria	J	Glutaminyl-tRNA synthetase	glnS	-	6.1.1.18	ko:K01886	ko00970,ko01100,map00970,map01100	M00359,M00360	R03652	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1c,tRNA-synt_1c_C
HKD3_k127_4439051_8	640081.Dsui_3268	8.759e-117	391.0	COG1570@1|root,COG1570@2|Bacteria,1MUA4@1224|Proteobacteria,2VJIC@28216|Betaproteobacteria,2KU79@206389|Rhodocyclales	206389|Rhodocyclales	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseA	-	3.1.11.6	ko:K03601	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_L,tRNA_anti_2
HKD3_k127_4439051_12	118161.KB235922_gene1131	1.465e-59	210.0	COG3837@1|root,COG3837@2|Bacteria,1G4Z5@1117|Cyanobacteria	1117|Cyanobacteria	S	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HKD3_k127_4439051_1	305700.B447_01256	1.757e-189	616.0	COG0082@1|root,COG0082@2|Bacteria,1MU98@1224|Proteobacteria,2VJA4@28216|Betaproteobacteria,2KUQ4@206389|Rhodocyclales	206389|Rhodocyclales	E	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system	aroC	-	4.2.3.5	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01714	RC00586	ko00000,ko00001,ko00002,ko01000	-	-	-	Chorismate_synt
HKD3_k127_4439051_10	42256.RradSPS_1336	5.708e-90	304.0	COG0846@1|root,COG0846@2|Bacteria,2GJI3@201174|Actinobacteria,4CU5Y@84995|Rubrobacteria	84995|Rubrobacteria	K	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form	-	-	-	ko:K12410	-	-	-	-	ko00000,ko01000	-	-	-	SIR2
HKD3_k127_4439051_4	522306.CAP2UW1_2481	6.118e-163	550.0	COG5373@1|root,COG5373@2|Bacteria,1N08V@1224|Proteobacteria,2VKJT@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Predicted membrane protein (DUF2339)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2339
HKD3_k127_4439051_0	748247.AZKH_0280	1.747e-246	784.0	COG0204@1|root,COG0204@2|Bacteria,1MWDY@1224|Proteobacteria,2VJ4I@28216|Betaproteobacteria,2KV3W@206389|Rhodocyclales	206389|Rhodocyclales	I	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	Acyltransferase,MFS_1
HKD3_k127_4439051_5	652103.Rpdx1_1864	4.784e-147	476.0	COG0207@1|root,COG0207@2|Bacteria,1MUBD@1224|Proteobacteria,2TQSB@28211|Alphaproteobacteria,3K2RP@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	F	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis	thyA	-	2.1.1.45	ko:K00560	ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523	M00053	R02101	RC00219,RC00332	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylat_synt
HKD3_k127_4439051_3	640081.Dsui_2360	2.25e-182	580.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VHSB@28216|Betaproteobacteria,2KVE6@206389|Rhodocyclales	206389|Rhodocyclales	T	COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains	-	-	-	ko:K07715	ko02020,ko02024,map02020,map02024	M00502	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Sigma54_activat
HKD3_k127_4439051_9	1123368.AUIS01000005_gene447	7.099e-113	381.0	COG0642@1|root,COG2205@2|Bacteria,1N58A@1224|Proteobacteria,1RP34@1236|Gammaproteobacteria,2NBSM@225057|Acidithiobacillales	225057|Acidithiobacillales	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	2.7.13.3	ko:K07711	ko02020,ko02024,map02020,map02024	M00502	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA
HKD3_k127_4439051_13	267608.RSc0946	3.474e-52	190.0	COG0262@1|root,COG0262@2|Bacteria,1RH0P@1224|Proteobacteria,2VSH8@28216|Betaproteobacteria,1K1KK@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis	folA	-	1.5.1.3	ko:K00287	ko00670,ko00790,ko01100,ko01523,map00670,map00790,map01100,map01523	M00126,M00840	R00936,R00937,R00939,R00940,R02235,R02236,R11765	RC00109,RC00110,RC00158	ko00000,ko00001,ko00002,ko01000	-	-	-	DHFR_1
HKD3_k127_4439051_11	864051.BurJ1DRAFT_1451	1.164e-70	244.0	28HPC@1|root,2Z7XD@2|Bacteria,1REIX@1224|Proteobacteria,2VS60@28216|Betaproteobacteria,1KMBS@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Domain of unknown function (DUF4337)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4337
HKD3_k127_4439051_6	640081.Dsui_3322	1.104e-122	403.0	COG0809@1|root,COG0809@2|Bacteria,1MUH3@1224|Proteobacteria,2VHJF@28216|Betaproteobacteria,2KVHN@206389|Rhodocyclales	206389|Rhodocyclales	F	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)	queA	-	2.4.99.17	ko:K07568	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Queuosine_synth
HKD3_k127_4439051_7	395494.Galf_2294	2.464e-121	395.0	COG0343@1|root,COG0343@2|Bacteria,1MUCA@1224|Proteobacteria,2VIRX@28216|Betaproteobacteria,44VPG@713636|Nitrosomonadales	28216|Betaproteobacteria	J	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)	tgt	-	2.4.2.29	ko:K00773	-	-	R03789,R10209	RC00063	ko00000,ko01000,ko03016	-	-	-	TGT
HKD3_k127_4477330_2	1411123.JQNH01000001_gene2795	6.727e-24	101.0	COG0493@1|root,COG1143@1|root,COG0493@2|Bacteria,COG1143@2|Bacteria,1MU2H@1224|Proteobacteria,2TQK5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases	MA20_01050	-	1.17.1.10	ko:K15022	ko00680,ko00720,ko01120,ko01200,map00680,map00720,map01120,map01200	M00377	R00134	RC02796	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4_20,Fer4_7,NADH_4Fe-4S,Pyr_redox_2,Pyr_redox_3
HKD3_k127_4477330_1	522306.CAP2UW1_2129	4.405e-145	467.0	COG0709@1|root,COG0709@2|Bacteria,1MWFG@1224|Proteobacteria,2VJSD@28216|Betaproteobacteria,1KQ8D@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	F	Synthesizes selenophosphate from selenide and ATP	selD	-	2.7.9.3	ko:K01008	ko00450,ko01100,map00450,map01100	-	R03595	RC00002,RC02878	ko00000,ko00001,ko01000,ko03016	-	-	-	AIRS,AIRS_C
HKD3_k127_4477330_0	94624.Bpet2716	1.816e-168	541.0	COG1262@1|root,COG1262@2|Bacteria,1MUNC@1224|Proteobacteria,2VH4V@28216|Betaproteobacteria,3T3DF@506|Alcaligenaceae	28216|Betaproteobacteria	NT	DinB superfamily	egtB	-	-	-	-	-	-	-	-	-	-	-	DinB_2,FGE-sulfatase
HKD3_k127_450890_0	62928.azo3482	1.86e-281	874.0	COG0243@1|root,COG3383@1|root,COG0243@2|Bacteria,COG3383@2|Bacteria,1MW3N@1224|Proteobacteria,2VJG2@28216|Betaproteobacteria,2KU82@206389|Rhodocyclales	206389|Rhodocyclales	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
HKD3_k127_450890_3	1502852.FG94_01123	9.509e-33	148.0	COG3381@1|root,COG3381@2|Bacteria,1MWWM@1224|Proteobacteria,2VJ39@28216|Betaproteobacteria,474I7@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Nitrate reductase delta subunit	torD	-	-	-	-	-	-	-	-	-	-	-	Nitrate_red_del
HKD3_k127_450890_1	204773.HEAR1409	1.709e-219	717.0	COG1148@1|root,COG1148@2|Bacteria,1QUQG@1224|Proteobacteria,2VMBE@28216|Betaproteobacteria,472MV@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_4,Fer4_6,Fer4_7
HKD3_k127_450890_4	305700.B447_11477	6.361e-22	109.0	2DNW4@1|root,32ZGA@2|Bacteria,1N7ZK@1224|Proteobacteria,2VWJH@28216|Betaproteobacteria,2KXB6@206389|Rhodocyclales	206389|Rhodocyclales	S	Protein of unknown function (DUF3306)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3306
HKD3_k127_450890_2	62928.azo3487	6.719e-37	145.0	COG0746@1|root,COG0746@2|Bacteria,1QVCV@1224|Proteobacteria,2WGQQ@28216|Betaproteobacteria	28216|Betaproteobacteria	H	Protein of unknown function (DUF3305)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3305
HKD3_k127_450890_6	1502852.FG94_03787	9.119e-09	59.0	COG2896@1|root,COG2896@2|Bacteria,1MW3W@1224|Proteobacteria,2VHW4@28216|Betaproteobacteria,4725J@75682|Oxalobacteraceae	28216|Betaproteobacteria	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	-	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Fer4_14,Mob_synth_C,Radical_SAM
HKD3_k127_450890_5	1476583.DEIPH_ctg029orf0001	6.406e-10	59.0	COG2896@1|root,COG2896@2|Bacteria,1WIGS@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	-	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Mob_synth_C,Radical_SAM
HKD3_k127_4510269_0	1288494.EBAPG3_15680	0.0	1028.0	COG0567@1|root,COG0567@2|Bacteria,1MVBF@1224|Proteobacteria,2VJ0G@28216|Betaproteobacteria,371W3@32003|Nitrosomonadales	28216|Betaproteobacteria	C	dehydrogenase, E1 component	sucA	-	1.2.4.2	ko:K00164	ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R00621,R01933,R01940,R03316,R08549	RC00004,RC00027,RC00627,RC02743,RC02833,RC02883	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr
HKD3_k127_4510269_17	1123367.C666_09550	6.963e-33	133.0	COG0508@1|root,COG0508@2|Bacteria,1MUJD@1224|Proteobacteria,2VIEM@28216|Betaproteobacteria,2KVIM@206389|Rhodocyclales	206389|Rhodocyclales	C	The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2)	odhB	-	2.3.1.61	ko:K00658	ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R02570,R02571,R08549	RC00004,RC02727,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
HKD3_k127_4510269_5	667632.KB890164_gene1841	1.522e-144	464.0	COG0508@1|root,COG0508@2|Bacteria,1MUJD@1224|Proteobacteria,2VIEM@28216|Betaproteobacteria,1K1V0@119060|Burkholderiaceae	28216|Betaproteobacteria	C	The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2)	sucB	-	2.3.1.61	ko:K00658	ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R02570,R02571,R08549	RC00004,RC02727,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
HKD3_k127_4510269_3	1349767.GJA_3483	1.21e-229	722.0	COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,2VI6G@28216|Betaproteobacteria,4734P@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain	odhL	GO:0003674,GO:0003824,GO:0004148,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005759,GO:0006082,GO:0006084,GO:0006085,GO:0006086,GO:0006090,GO:0006139,GO:0006163,GO:0006164,GO:0006464,GO:0006637,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0018130,GO:0018335,GO:0019362,GO:0019438,GO:0019538,GO:0019637,GO:0019693,GO:0019752,GO:0031974,GO:0031981,GO:0032787,GO:0032991,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0035383,GO:0035384,GO:0036211,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043412,GO:0043436,GO:0043543,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044272,GO:0044281,GO:0044422,GO:0044424,GO:0044428,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045254,GO:0046390,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0055114,GO:0061732,GO:0070013,GO:0071616,GO:0071704,GO:0072521,GO:0072522,GO:0072524,GO:0090407,GO:0106077,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902494,GO:1990204,GO:1990234	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
HKD3_k127_4510269_7	305700.B447_10258	6.709e-126	416.0	COG1485@1|root,COG1485@2|Bacteria,1MUUW@1224|Proteobacteria,2VHQX@28216|Betaproteobacteria,2KUMJ@206389|Rhodocyclales	206389|Rhodocyclales	S	AFG1-like ATPase	afg	-	-	ko:K06916	-	-	-	-	ko00000,ko03036	-	-	-	AFG1_ATPase
HKD3_k127_4510269_8	1304883.KI912532_gene3006	8.275e-112	372.0	COG0604@1|root,COG0604@2|Bacteria,1MV3W@1224|Proteobacteria,2VINX@28216|Betaproteobacteria,2KU9K@206389|Rhodocyclales	206389|Rhodocyclales	C	COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases	-	-	1.1.1.1	ko:K00001	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
HKD3_k127_4510269_2	1163617.SCD_n01505	1.36e-317	1003.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2VI3T@28216|Betaproteobacteria	28216|Betaproteobacteria	I	PrpE from Ralstonia solanacearum can produce acetyl-, propionyl-, butyryl- and acrylyl-coenzyme A, and Salmonella enterica produces propionyl- and butyryl-coenzyme A	prpE	-	6.2.1.17	ko:K01908	ko00640,ko01100,map00640,map01100	-	R00926,R01354	RC00004,RC00043,RC00070,RC02816	ko00000,ko00001,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
HKD3_k127_4510269_10	883126.HMPREF9710_03650	3.319e-103	347.0	COG4448@1|root,COG4448@2|Bacteria,1R4NH@1224|Proteobacteria,2VJES@28216|Betaproteobacteria,476PU@75682|Oxalobacteraceae	28216|Betaproteobacteria	E	L-asparaginase II	-	-	-	-	-	-	-	-	-	-	-	-	Asparaginase_II
HKD3_k127_4510269_13	1163617.SCD_n01390	6.381e-98	322.0	COG1595@1|root,COG1595@2|Bacteria,1MX7T@1224|Proteobacteria,2VHR2@28216|Betaproteobacteria	28216|Betaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	rpoE	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD3_k127_4510269_18	1485544.JQKP01000010_gene786	8.804e-18	96.0	COG3073@1|root,COG3073@2|Bacteria,1QANZ@1224|Proteobacteria,2VVPR@28216|Betaproteobacteria,44VXX@713636|Nitrosomonadales	28216|Betaproteobacteria	T	PFAM Anti sigma-E protein RseA family protein	rseA	-	-	ko:K03597	-	-	-	-	ko00000,ko03021	-	-	-	RseA_N
HKD3_k127_4510269_14	497321.C664_06953	1.146e-70	252.0	COG3026@1|root,COG3026@2|Bacteria,1MUQ8@1224|Proteobacteria,2VMZQ@28216|Betaproteobacteria,2KUKH@206389|Rhodocyclales	206389|Rhodocyclales	T	Sigma E regulatory protein, MucB RseB	rseB	-	-	ko:K03598	-	-	-	-	ko00000,ko03021	-	-	-	MucB_RseB,MucB_RseB_C
HKD3_k127_4510269_4	640081.Dsui_2455	4.369e-159	523.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2VI4Q@28216|Betaproteobacteria,2KUVY@206389|Rhodocyclales	206389|Rhodocyclales	M	Belongs to the peptidase S1C family	degQ	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
HKD3_k127_4510269_19	159087.Daro_2025	1.129e-17	87.0	COG0526@1|root,COG0526@2|Bacteria,1QVC9@1224|Proteobacteria,2VYGG@28216|Betaproteobacteria,2KXAK@206389|Rhodocyclales	206389|Rhodocyclales	CO	COG0526 Thiol-disulfide isomerase and thioredoxins	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	DUF836
HKD3_k127_4510269_1	323848.Nmul_A1751	3.169e-320	989.0	COG0481@1|root,COG0481@2|Bacteria,1MVZA@1224|Proteobacteria,2VHM5@28216|Betaproteobacteria,372EW@32003|Nitrosomonadales	28216|Betaproteobacteria	J	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner	lepA	-	-	ko:K03596	ko05134,map05134	-	-	-	ko00000,ko00001	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2,LepA_C
HKD3_k127_4510269_11	1288494.EBAPG3_14260	9.421e-100	333.0	COG0681@1|root,COG0681@2|Bacteria,1MXUF@1224|Proteobacteria,2VJ9D@28216|Betaproteobacteria,371PT@32003|Nitrosomonadales	28216|Betaproteobacteria	U	Belongs to the peptidase S26 family	lepB	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24,Peptidase_S26
HKD3_k127_4510269_20	1123392.AQWL01000001_gene1392	1.242e-13	78.0	COG4969@1|root,COG4969@2|Bacteria,1N71K@1224|Proteobacteria,2WAFV@28216|Betaproteobacteria,1KT97@119069|Hydrogenophilales	119069|Hydrogenophilales	NU	Domain of unknown function (DUF4845)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4845
HKD3_k127_4510269_15	292415.Tbd_2086	2.208e-70	245.0	COG0571@1|root,COG0571@2|Bacteria,1MUQ6@1224|Proteobacteria,2VI4M@28216|Betaproteobacteria,1KRNX@119069|Hydrogenophilales	119069|Hydrogenophilales	J	Ribonuclease III family	-	-	3.1.26.3	ko:K03685	ko03008,ko05205,map03008,map05205	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019,ko03036	-	-	-	Ribonucleas_3_3,dsrm
HKD3_k127_4510269_12	1121035.AUCH01000001_gene1913	2.202e-98	338.0	COG1159@1|root,COG1159@2|Bacteria,1MUKT@1224|Proteobacteria,2VHYP@28216|Betaproteobacteria,2KVT3@206389|Rhodocyclales	206389|Rhodocyclales	S	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism	era	-	-	ko:K03595	-	-	-	-	ko00000,ko03009,ko03029	-	-	-	KH_2,MMR_HSR1
HKD3_k127_4510269_16	1123367.C666_08470	1.018e-65	235.0	COG1381@1|root,COG1381@2|Bacteria,1RHIC@1224|Proteobacteria,2VJUC@28216|Betaproteobacteria,2KW9J@206389|Rhodocyclales	206389|Rhodocyclales	L	Involved in DNA repair and RecF pathway recombination	recO	-	-	ko:K03584	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecO_C,RecO_N
HKD3_k127_4510269_6	748247.AZKH_2832	7.826e-128	420.0	COG0854@1|root,COG0854@2|Bacteria,1MU9W@1224|Proteobacteria,2VHY7@28216|Betaproteobacteria,2KV09@206389|Rhodocyclales	206389|Rhodocyclales	H	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate	pdxJ	-	2.6.99.2	ko:K03474	ko00750,ko01100,map00750,map01100	M00124	R05838	RC01476	ko00000,ko00001,ko00002,ko01000	-	-	-	PdxJ
HKD3_k127_4510269_9	1485544.JQKP01000013_gene1798	3.531e-106	351.0	COG1472@1|root,COG1472@2|Bacteria,1MVAJ@1224|Proteobacteria,2VHAR@28216|Betaproteobacteria,44V3T@713636|Nitrosomonadales	28216|Betaproteobacteria	G	Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides	nagZ	-	2.7.8.7,3.2.1.52	ko:K00997,ko:K01207	ko00520,ko00531,ko00770,ko01100,ko01501,map00520,map00531,map00770,map01100,map01501	M00628	R00022,R01625,R05963,R07809,R07810,R10831	RC00002,RC00049	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyco_hydro_3
HKD3_k127_4601980_1	637905.SVI_2049	3.734e-53	199.0	COG1502@1|root,COG1502@2|Bacteria,1MWUW@1224|Proteobacteria,1RPQG@1236|Gammaproteobacteria,2QATE@267890|Shewanellaceae	1236|Gammaproteobacteria	I	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol	cls	GO:0003674,GO:0003824,GO:0005575,GO:0006629,GO:0006644,GO:0006650,GO:0006655,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0008808,GO:0009058,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016780,GO:0019637,GO:0030572,GO:0032048,GO:0032049,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0045017,GO:0046471,GO:0046474,GO:0046486,GO:0071704,GO:0090407,GO:1901576	-	ko:K06131	ko00564,ko01100,map00564,map01100	-	R07390	RC00017	ko00000,ko00001,ko01000	-	-	iSDY_1059.SDY_1307	PLDc_2,PLDc_N
HKD3_k127_4601980_0	1366050.N234_03455	5.064e-56	205.0	COG1522@1|root,COG1522@2|Bacteria,1MZ9D@1224|Proteobacteria,2VR5I@28216|Betaproteobacteria,1KH89@119060|Burkholderiaceae	28216|Betaproteobacteria	K	AsnC-type helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
HKD3_k127_4601980_2	614083.AWQR01000036_gene1299	4.687e-43	160.0	COG0010@1|root,COG0010@2|Bacteria,1MVFH@1224|Proteobacteria,2VJU2@28216|Betaproteobacteria,4AB3J@80864|Comamonadaceae	28216|Betaproteobacteria	E	Belongs to the arginase family	rocF	-	3.5.3.1,3.5.3.11,3.5.3.17,3.5.3.7	ko:K01476,ko:K01480,ko:K12255,ko:K18459	ko00220,ko00330,ko01100,ko01110,ko01130,ko01230,ko05146,map00220,map00330,map01100,map01110,map01130,map01230,map05146	M00029,M00133,M00134	R00551,R01157,R01990	RC00024,RC00329	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
HKD3_k127_469236_12	1265502.KB905929_gene2317	1.147e-19	90.0	COG0294@1|root,COG0294@2|Bacteria,1MUIR@1224|Proteobacteria,2VH2Q@28216|Betaproteobacteria,4AAWK@80864|Comamonadaceae	28216|Betaproteobacteria	H	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives	folP	-	2.5.1.15	ko:K00796	ko00790,ko01100,map00790,map01100	M00126,M00841	R03066,R03067	RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
HKD3_k127_469236_1	1121035.AUCH01000002_gene1697	4.479e-176	567.0	COG1109@1|root,COG1109@2|Bacteria,1MU24@1224|Proteobacteria,2VI3U@28216|Betaproteobacteria,2KUMC@206389|Rhodocyclales	206389|Rhodocyclales	G	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate	glmM	-	5.4.2.10	ko:K03431	ko00520,ko01100,ko01130,map00520,map01100,map01130	-	R02060	RC00408	ko00000,ko00001,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
HKD3_k127_469236_0	1121035.AUCH01000001_gene2041	1.506e-241	768.0	COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,2VHSK@28216|Betaproteobacteria,2KV96@206389|Rhodocyclales	206389|Rhodocyclales	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	relA	-	2.7.6.5	ko:K00951	ko00230,map00230	-	R00429	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
HKD3_k127_469236_5	640081.Dsui_2455	7.411e-147	488.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2VI4Q@28216|Betaproteobacteria,2KUVY@206389|Rhodocyclales	206389|Rhodocyclales	M	Belongs to the peptidase S1C family	degQ	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
HKD3_k127_469236_7	261292.Nit79A3_3087	1.63e-115	390.0	COG5544@1|root,COG5544@2|Bacteria,1QU58@1224|Proteobacteria,2VQZ5@28216|Betaproteobacteria,3720M@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Lipoprotein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_469236_2	365046.Rta_38020	2.677e-169	561.0	COG2059@1|root,COG2059@2|Bacteria,1MUBW@1224|Proteobacteria,2VHPW@28216|Betaproteobacteria,4AABT@80864|Comamonadaceae	28216|Betaproteobacteria	P	TIGRFAM chromate transporter, chromate ion transporter (CHR) family	chrA	-	-	ko:K07240	-	-	-	-	ko00000,ko02000	2.A.51.1	-	-	Chromate_transp
HKD3_k127_469236_4	666681.M301_2452	2.351e-149	484.0	COG0303@1|root,COG0303@2|Bacteria,1MVD5@1224|Proteobacteria,2VH78@28216|Betaproteobacteria,2KKRZ@206350|Nitrosomonadales	206350|Nitrosomonadales	H	PFAM MoeA domain protein domain I and II	-	-	2.10.1.1	ko:K03750	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N
HKD3_k127_469236_8	748247.AZKH_0068	1.801e-75	265.0	COG0746@1|root,COG0746@2|Bacteria,1RH3M@1224|Proteobacteria,2VQR2@28216|Betaproteobacteria,2KW8P@206389|Rhodocyclales	206389|Rhodocyclales	H	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor	mobA	-	2.7.7.77	ko:K03752	ko00790,ko01100,map00790,map01100	-	R11581	-	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
HKD3_k127_469236_10	1385517.N800_12720	2.047e-36	159.0	COG3791@1|root,COG3791@2|Bacteria,1N031@1224|Proteobacteria,1S69Q@1236|Gammaproteobacteria,1X8MY@135614|Xanthomonadales	135614|Xanthomonadales	S	Glutathione-dependent formaldehyde-activating enzyme	-	-	-	-	-	-	-	-	-	-	-	-	GFA
HKD3_k127_469236_6	1000565.METUNv1_04051	1.416e-118	386.0	COG1526@1|root,COG1526@2|Bacteria,1MY28@1224|Proteobacteria,2VK94@28216|Betaproteobacteria,2KV23@206389|Rhodocyclales	206389|Rhodocyclales	C	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH	fdhD	-	-	ko:K02379	-	-	-	-	ko00000	-	-	-	FdhD-NarQ
HKD3_k127_469236_3	1000565.METUNv1_04052	4.274e-162	518.0	COG2896@1|root,COG2896@2|Bacteria,1MW3W@1224|Proteobacteria,2VHW4@28216|Betaproteobacteria,2KURW@206389|Rhodocyclales	206389|Rhodocyclales	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	-	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Fer4_14,Mob_synth_C,Radical_SAM
HKD3_k127_469236_9	62928.azo3487	1.727e-36	143.0	COG0746@1|root,COG0746@2|Bacteria,1QVCV@1224|Proteobacteria,2WGQQ@28216|Betaproteobacteria	28216|Betaproteobacteria	H	Protein of unknown function (DUF3305)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3305
HKD3_k127_469236_11	305700.B447_11477	4.621e-23	112.0	2DNW4@1|root,32ZGA@2|Bacteria,1N7ZK@1224|Proteobacteria,2VWJH@28216|Betaproteobacteria,2KXB6@206389|Rhodocyclales	206389|Rhodocyclales	S	Protein of unknown function (DUF3306)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3306
HKD3_k127_4851484_6	84531.JMTZ01000014_gene2757	1.764e-33	135.0	COG0637@1|root,COG0637@2|Bacteria,1R8Z3@1224|Proteobacteria,1S4ZI@1236|Gammaproteobacteria,1XCM1@135614|Xanthomonadales	135614|Xanthomonadales	S	HAD-hyrolase-like	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
HKD3_k127_4851484_1	204773.HEAR0257	6.277e-83	281.0	COG0632@1|root,COG0632@2|Bacteria,1MWJR@1224|Proteobacteria,2VJ98@28216|Betaproteobacteria,473AX@75682|Oxalobacteraceae	28216|Betaproteobacteria	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB	ruvA	-	3.6.4.12	ko:K03550	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HHH_5,RuvA_C,RuvA_N
HKD3_k127_4851484_3	748280.NH8B_3348	8.727e-47	183.0	COG2050@1|root,COG2050@2|Bacteria,1RH0Z@1224|Proteobacteria,2VT69@28216|Betaproteobacteria,2KQKG@206351|Neisseriales	206351|Neisseriales	Q	Domain of unknown function (DUF4442)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4442
HKD3_k127_4851484_0	977880.RALTA_A0453	1.966e-174	552.0	COG2255@1|root,COG2255@2|Bacteria,1MU38@1224|Proteobacteria,2VH0J@28216|Betaproteobacteria,1K2TQ@119060|Burkholderiaceae	28216|Betaproteobacteria	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing	ruvB	-	3.6.4.12	ko:K03551	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvB_C,RuvB_N
HKD3_k127_4851484_7	1121035.AUCH01000008_gene1062	1.677e-30	137.0	COG0824@1|root,COG0824@2|Bacteria,1MZH6@1224|Proteobacteria,2VUEV@28216|Betaproteobacteria,2KWWA@206389|Rhodocyclales	206389|Rhodocyclales	S	Tol-pal system-associated acyl-CoA thioesterase	-	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT
HKD3_k127_4851484_2	305700.B447_12262	7.805e-81	280.0	COG0811@1|root,COG0811@2|Bacteria,1NCWW@1224|Proteobacteria,2VJPW@28216|Betaproteobacteria,2KV8T@206389|Rhodocyclales	206389|Rhodocyclales	U	MotA TolQ ExbB proton channel	tolQ	-	-	ko:K03562	ko01120,map01120	-	-	-	ko00000,ko02000	1.A.30.2.2	-	-	MotA_ExbB
HKD3_k127_4851484_4	1163617.SCD_n00674	5.611e-42	158.0	COG0848@1|root,COG0848@2|Bacteria,1RGWR@1224|Proteobacteria,2VT20@28216|Betaproteobacteria	28216|Betaproteobacteria	U	Pfam Biopolymer transport protein ExbD TolR	tolR	-	-	ko:K03560	-	-	-	-	ko00000,ko02000	1.A.30.2.2	-	-	ExbD
HKD3_k127_4851484_5	748247.AZKH_4298	1.58e-37	156.0	COG3064@1|root,COG3064@2|Bacteria,1RKZU@1224|Proteobacteria,2WGP5@28216|Betaproteobacteria,2KZNR@206389|Rhodocyclales	206389|Rhodocyclales	M	TonB C terminal	-	-	-	ko:K03646	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	TonB_2
HKD3_k127_4851484_8	1123392.AQWL01000004_gene2747	3.649e-15	87.0	2DBUQ@1|root,2ZB76@2|Bacteria,1R4DM@1224|Proteobacteria,2VS5V@28216|Betaproteobacteria,1KSNQ@119069|Hydrogenophilales	119069|Hydrogenophilales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_4862152_3	1304883.KI912532_gene31	1.218e-84	282.0	COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,2VI4A@28216|Betaproteobacteria,2KUXH@206389|Rhodocyclales	206389|Rhodocyclales	EF	Belongs to the CarB family	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
HKD3_k127_4862152_1	62928.azo1381	1.908e-174	555.0	COG0505@1|root,COG0505@2|Bacteria,1MUB9@1224|Proteobacteria,2VH9Q@28216|Betaproteobacteria,2KUWH@206389|Rhodocyclales	206389|Rhodocyclales	F	Belongs to the CarA family	carA	-	6.3.5.5	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_sm_chain,GATase
HKD3_k127_4862152_4	1411123.JQNH01000001_gene929	1.33e-82	285.0	COG1028@1|root,COG1028@2|Bacteria,1MWB6@1224|Proteobacteria,2TTVF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	IQ	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	-	-	1.1.1.69	ko:K00046	-	-	-	-	ko00000,ko01000	-	-	-	adh_short_C2
HKD3_k127_4862152_2	987059.RBXJA2T_02822	4.969e-100	333.0	COG0289@1|root,COG0289@2|Bacteria,1MUCT@1224|Proteobacteria,2VJC3@28216|Betaproteobacteria,1KJ45@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate	dapB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008839,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019752,GO:0019877,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576	1.17.1.8	ko:K00215	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R04198,R04199	RC00478	ko00000,ko00001,ko00002,ko01000	-	-	-	DapB_C,DapB_N
HKD3_k127_4862152_8	1071679.BG57_08210	4.602e-25	116.0	COG2913@1|root,COG2913@2|Bacteria,1N6YW@1224|Proteobacteria,2VRC6@28216|Betaproteobacteria,1K28P@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamE	-	-	ko:K06186	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	SmpA_OmlA
HKD3_k127_4862152_5	522306.CAP2UW1_3736	6.42e-66	237.0	COG0735@1|root,COG0735@2|Bacteria,1RDWJ@1224|Proteobacteria,2VR52@28216|Betaproteobacteria,1KQQD@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	K	Ferric uptake regulator family	fur	-	-	ko:K03711	-	-	-	-	ko00000,ko03000	-	-	-	FUR
HKD3_k127_4862152_0	305700.B447_00235	5.435e-181	582.0	COG0728@1|root,COG0728@2|Bacteria,1MUH0@1224|Proteobacteria,2VHTQ@28216|Betaproteobacteria,2KVHB@206389|Rhodocyclales	206389|Rhodocyclales	S	Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane	murJ	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
HKD3_k127_4862152_9	640081.Dsui_3254	1.211e-18	98.0	COG0268@1|root,COG0268@2|Bacteria,1MZ94@1224|Proteobacteria,2VTYY@28216|Betaproteobacteria,2KWZ9@206389|Rhodocyclales	206389|Rhodocyclales	J	Binds directly to 16S ribosomal RNA	rpsT	-	-	ko:K02968	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S20p
HKD3_k127_4862152_7	1267534.KB906756_gene707	2.436e-32	128.0	2CIGD@1|root,2ZM6I@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_4862152_6	746697.Aeqsu_2660	3.568e-34	140.0	COG4447@1|root,COG4447@2|Bacteria,4NEZQ@976|Bacteroidetes,1HWS9@117743|Flavobacteriia	976|Bacteroidetes	G	alpha-L-arabinofuranosidase	-	-	-	-	-	-	-	-	-	-	-	-	Sortilin-Vps10
HKD3_k127_4864382_4	1380394.JADL01000008_gene3595	9.54e-80	272.0	COG3342@1|root,COG3342@2|Bacteria,1MWQT@1224|Proteobacteria,2TRJZ@28211|Alphaproteobacteria,2JWJI@204441|Rhodospirillales	204441|Rhodospirillales	S	Family of unknown function (DUF1028)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1028
HKD3_k127_4864382_0	1380394.JADL01000008_gene3592	2.281e-198	631.0	COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,2TR1D@28211|Alphaproteobacteria,2JVA4@204441|Rhodospirillales	204441|Rhodospirillales	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
HKD3_k127_4864382_1	1380394.JADL01000008_gene3591	1.327e-149	478.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2TR0N@28211|Alphaproteobacteria,2JZH9@204441|Rhodospirillales	204441|Rhodospirillales	EP	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
HKD3_k127_4864382_3	1380394.JADL01000008_gene3590	6.06e-123	417.0	COG1173@1|root,COG1173@2|Bacteria,1MUG0@1224|Proteobacteria,2VETJ@28211|Alphaproteobacteria,2JV54@204441|Rhodospirillales	204441|Rhodospirillales	EP	N-terminal TM domain of oligopeptide transport permease C	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
HKD3_k127_4864382_2	1366050.N234_29715	6.09e-146	477.0	COG5361@1|root,COG5361@2|Bacteria,1MWTW@1224|Proteobacteria,2VMX9@28216|Betaproteobacteria,1K0PN@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Protein of unknown function (DUF1254)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1214,DUF1254
HKD3_k127_4870994_2	1121033.AUCF01000012_gene850	1.262e-70	248.0	28I53@1|root,2Z88I@2|Bacteria,1NE5N@1224|Proteobacteria,2TTBB@28211|Alphaproteobacteria,2JSU5@204441|Rhodospirillales	204441|Rhodospirillales	S	Protein of unknown function (DUF3750)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3750
HKD3_k127_4870994_5	234267.Acid_5427	2.426e-30	126.0	COG0664@1|root,COG0664@2|Bacteria	2|Bacteria	T	cyclic nucleotide binding	crp	-	1.8.1.9	ko:K00384,ko:K10914	ko00450,ko02020,ko02024,ko02025,ko02026,ko05111,map00450,map02020,map02024,map02025,map02026,map05111	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000,ko03000	-	-	-	cNMP_binding
HKD3_k127_4870994_0	661478.OP10G_1117	3.087e-180	571.0	COG1830@1|root,COG1830@2|Bacteria	2|Bacteria	G	lyase activity	fbaB	GO:0003674,GO:0003824,GO:0004332,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016829,GO:0016830,GO:0016832,GO:0042802,GO:0044424,GO:0044444,GO:0044464	4.1.2.13	ko:K11645	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	iETEC_1333.ETEC_2236,iSBO_1134.SBO_0918,iUMNK88_1353.UMNK88_2640	DeoC
HKD3_k127_4870994_3	247634.GPB2148_932	1.63e-42	163.0	COG1764@1|root,COG1764@2|Bacteria,1RJIP@1224|Proteobacteria,1S6QM@1236|Gammaproteobacteria,1J9ZC@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	O	redox protein, regulator of disulfide bond formation	-	-	-	-	-	-	-	-	-	-	-	-	OsmC
HKD3_k127_4870994_4	471853.Bcav_3927	3.65e-31	132.0	2C4FF@1|root,30I7M@2|Bacteria,2IJJV@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_4870994_1	426117.M446_0613	2.057e-137	445.0	COG0667@1|root,COG0667@2|Bacteria,1MVEH@1224|Proteobacteria,2TRHS@28211|Alphaproteobacteria,1JT1V@119045|Methylobacteriaceae	28211|Alphaproteobacteria	C	PFAM aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
HKD3_k127_4872723_0	1110502.TMO_2246	1.119e-217	687.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria,2JPMJ@204441|Rhodospirillales	204441|Rhodospirillales	V	COG0841 Cation multidrug efflux pump	-	-	-	ko:K18902,ko:K19594	-	M00698,M00768,M00769	-	-	ko00000,ko00002,ko01504,ko02000	2.A.6.2,2.A.6.2.25,2.A.6.2.34	-	-	ACR_tran
HKD3_k127_4872723_1	1500893.JQNB01000001_gene852	2.623e-70	251.0	COG0845@1|root,COG0845@2|Bacteria,1MU78@1224|Proteobacteria,1RMI7@1236|Gammaproteobacteria,1X38S@135614|Xanthomonadales	135614|Xanthomonadales	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K18298,ko:K19586	-	M00641,M00767	-	-	ko00000,ko00002,ko01504,ko02000	2.A.6.2.47,8.A.1	-	-	Biotin_lipoyl_2,HlyD_D23
HKD3_k127_4909116_0	604331.AUHY01000006_gene836	0.0	1142.0	COG0654@1|root,COG1902@1|root,COG0654@2|Bacteria,COG1902@2|Bacteria,1WIIR@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	PFAM NADH flavin oxidoreductase NADH oxidase	-	-	1.14.13.40	ko:K09461	ko00627,ko01120,map00627,map01120	-	R03998,R03999	RC00244	ko00000,ko00001,ko01000	-	-	-	FAD_binding_3,Oxidored_FMN
HKD3_k127_4909116_2	388051.AUFE01000010_gene2625	9.23e-90	303.0	COG1028@1|root,COG1028@2|Bacteria,1MUS7@1224|Proteobacteria,2VM6S@28216|Betaproteobacteria,1K3I3@119060|Burkholderiaceae	28216|Betaproteobacteria	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	abmB	GO:0003674,GO:0003824,GO:0006725,GO:0008150,GO:0008152,GO:0009987,GO:0010130,GO:0016043,GO:0016491,GO:0016614,GO:0016616,GO:0018913,GO:0018915,GO:0022607,GO:0042537,GO:0043933,GO:0044085,GO:0044237,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:1901360	1.1.1.30	ko:K00019,ko:K07535	ko00072,ko00362,ko00650,ko01100,ko01120,ko01220,map00072,map00362,map00650,map01100,map01120,map01220	M00088,M00540	R01361,R05582	RC00117,RC00154	ko00000,ko00001,ko00002,ko01000	-	-	-	adh_short,adh_short_C2
HKD3_k127_4909116_3	365046.Rta_35040	2.367e-52	201.0	COG1846@1|root,COG1846@2|Bacteria,1MZE9@1224|Proteobacteria,2VT2T@28216|Betaproteobacteria,4ADVS@80864|Comamonadaceae	28216|Betaproteobacteria	K	PFAM regulatory protein, MarR	badR	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
HKD3_k127_4909116_1	1156919.QWC_23635	1.993e-127	412.0	COG1024@1|root,COG1024@2|Bacteria,1MXHV@1224|Proteobacteria,2VHSP@28216|Betaproteobacteria,3T354@506|Alcaligenaceae	28216|Betaproteobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	abmC	-	-	-	-	-	-	-	-	-	-	-	ECH_1
HKD3_k127_4966218_3	382464.ABSI01000013_gene1570	2.849e-244	800.0	COG2114@1|root,COG3899@1|root,COG3903@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,COG3903@2|Bacteria,46U27@74201|Verrucomicrobia	74201|Verrucomicrobia	T	AAA ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,Guanylate_cyc
HKD3_k127_4966218_18	1000565.METUNv1_00089	1.072e-87	298.0	COG4582@1|root,COG4582@2|Bacteria,1MW69@1224|Proteobacteria,2VIIG@28216|Betaproteobacteria,2KUR3@206389|Rhodocyclales	206389|Rhodocyclales	D	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity	zapD	-	-	ko:K18778	-	-	-	-	ko00000,ko03036	-	-	-	ZapD
HKD3_k127_4966218_27	243233.MCA2093	5.636e-50	197.0	COG0237@1|root,COG0237@2|Bacteria,1RCXT@1224|Proteobacteria,1S3NR@1236|Gammaproteobacteria,1XF4I@135618|Methylococcales	135618|Methylococcales	F	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A	coaE	-	2.7.1.24	ko:K00859	ko00770,ko01100,map00770,map01100	M00120	R00130	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	CoaE
HKD3_k127_4966218_13	1123367.C666_04905	3.649e-105	350.0	COG1989@1|root,COG1989@2|Bacteria,1MUZF@1224|Proteobacteria,2VI08@28216|Betaproteobacteria,2KVU7@206389|Rhodocyclales	206389|Rhodocyclales	NOU	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue	pilD	-	3.4.23.43	ko:K02654	-	M00331	-	-	ko00000,ko00002,ko01000,ko01002,ko02035,ko02044	3.A.15.2	-	-	DiS_P_DiS,Peptidase_A24
HKD3_k127_4966218_8	1005048.CFU_3923	5.641e-160	514.0	COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,2VHPE@28216|Betaproteobacteria,473ER@75682|Oxalobacteraceae	28216|Betaproteobacteria	NU	type II secretion system protein	pilC	-	-	ko:K02653	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSF
HKD3_k127_4966218_1	1163617.SCD_n02465	8.825e-260	813.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,2VHQ1@28216|Betaproteobacteria	28216|Betaproteobacteria	NU	type II secretion system protein E	pilB	-	-	ko:K02454,ko:K02504,ko:K02652,ko:K12276	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15,3.A.15.2	-	-	T2SSE,T2SSE_N
HKD3_k127_4966218_9	1000565.METUNv1_02895	1.823e-137	449.0	COG4536@1|root,COG4536@2|Bacteria,1NZ99@1224|Proteobacteria,2WGFR@28216|Betaproteobacteria,2KV1H@206389|Rhodocyclales	206389|Rhodocyclales	P	Transporter associated domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
HKD3_k127_4966218_24	323848.Nmul_A2133	1.754e-55	205.0	COG4137@1|root,COG4137@2|Bacteria,1R3YD@1224|Proteobacteria,2VK0H@28216|Betaproteobacteria,371QS@32003|Nitrosomonadales	28216|Betaproteobacteria	S	PFAM Cytochrome c assembly protein	ypjD	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C_asm
HKD3_k127_4966218_5	76114.ebA4351	9.032e-210	660.0	COG0541@1|root,COG0541@2|Bacteria,1MVIA@1224|Proteobacteria,2VJ3W@28216|Betaproteobacteria,2KUVT@206389|Rhodocyclales	206389|Rhodocyclales	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components	ffh	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
HKD3_k127_4966218_33	1163617.SCD_n02461	5.068e-31	126.0	COG0228@1|root,COG0228@2|Bacteria,1MZCT@1224|Proteobacteria,2VTYP@28216|Betaproteobacteria	28216|Betaproteobacteria	J	Belongs to the bacterial ribosomal protein bS16 family	rpsP	-	-	ko:K02959	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S16
HKD3_k127_4966218_29	1163617.SCD_n02460	8.462e-40	153.0	COG0806@1|root,COG0806@2|Bacteria,1MWQR@1224|Proteobacteria,2VQ0H@28216|Betaproteobacteria	28216|Betaproteobacteria	J	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes	rimM	-	-	ko:K02860	-	-	-	-	ko00000,ko03009	-	-	-	PRC,RimM
HKD3_k127_4966218_17	395494.Galf_2707	8.245e-91	305.0	COG0336@1|root,COG0336@2|Bacteria,1MUN1@1224|Proteobacteria,2VHPY@28216|Betaproteobacteria,44V1B@713636|Nitrosomonadales	28216|Betaproteobacteria	J	Belongs to the RNA methyltransferase TrmD family	trmD	-	2.1.1.228	ko:K00554	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	tRNA_m1G_MT
HKD3_k127_4966218_25	358220.C380_06780	2.089e-55	207.0	COG0335@1|root,COG0335@2|Bacteria,1RH3A@1224|Proteobacteria,2VR2S@28216|Betaproteobacteria,4ADW5@80864|Comamonadaceae	28216|Betaproteobacteria	J	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site	rplS	-	-	ko:K02884	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L19
HKD3_k127_4966218_36	1160718.SU9_15407	6.203e-05	56.0	COG0484@1|root,COG0484@2|Bacteria,2GJKK@201174|Actinobacteria	201174|Actinobacteria	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0010468,GO:0016020,GO:0019222,GO:0030312,GO:0040007,GO:0043388,GO:0044093,GO:0044464,GO:0050789,GO:0051098,GO:0051099,GO:0051101,GO:0060255,GO:0065007,GO:0065009,GO:0071944,GO:2000677,GO:2000679	-	ko:K03686,ko:K05516	-	-	-	-	ko00000,ko03029,ko03036,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
HKD3_k127_4966218_35	768704.Desmer_2444	1.562e-12	81.0	COG1714@1|root,COG1714@2|Bacteria,1VKXD@1239|Firmicutes	1239|Firmicutes	S	RDD family	-	-	-	-	-	-	-	-	-	-	-	-	RDD
HKD3_k127_4966218_22	757424.Hsero_0841	4.58e-66	235.0	COG0679@1|root,COG0679@2|Bacteria,1N1X9@1224|Proteobacteria,2VIM5@28216|Betaproteobacteria,473AY@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Membrane transport protein	-	-	-	ko:K07088	-	-	-	-	ko00000	-	-	-	Mem_trans
HKD3_k127_4966218_26	489653.NLA_2460	5.152e-53	193.0	COG0615@1|root,COG0615@2|Bacteria,1REW3@1224|Proteobacteria,2VR6S@28216|Betaproteobacteria,2KQV5@206351|Neisseriales	206351|Neisseriales	H	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose	-	-	2.7.7.70	ko:K21345	ko00540,ko01100,map00540,map01100	M00064	R05644	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
HKD3_k127_4966218_31	1163617.SCD_n02503	4.34e-37	150.0	COG2823@1|root,COG2823@2|Bacteria,1MUZ2@1224|Proteobacteria,2VQIS@28216|Betaproteobacteria	28216|Betaproteobacteria	S	PFAM transport-associated	-	-	-	-	-	-	-	-	-	-	-	-	BON
HKD3_k127_4966218_19	1120999.JONM01000007_gene1809	7.439e-77	261.0	COG0279@1|root,COG0279@2|Bacteria,1NJ8X@1224|Proteobacteria,2VN12@28216|Betaproteobacteria,2KPW6@206351|Neisseriales	206351|Neisseriales	G	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate	gmhA	-	5.3.1.28	ko:K03271	ko00540,ko01100,map00540,map01100	M00064	R05645,R09768,R09769	RC00434	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	SIS_2
HKD3_k127_4966218_34	323848.Nmul_A0195	2.173e-27	117.0	COG0792@1|root,COG0792@2|Bacteria,1N6VN@1224|Proteobacteria,2VU20@28216|Betaproteobacteria,373I0@32003|Nitrosomonadales	28216|Betaproteobacteria	L	Belongs to the UPF0102 family	-	-	-	ko:K07460	-	-	-	-	ko00000	-	-	-	UPF0102
HKD3_k127_4966218_30	1163617.SCD_n02500	9.24e-38	159.0	COG3107@1|root,COG3107@2|Bacteria,1MUHR@1224|Proteobacteria,2VSUT@28216|Betaproteobacteria	28216|Betaproteobacteria	M	LppC putative lipoprotein	-	-	-	ko:K07121	-	-	-	-	ko00000	-	-	-	LppC
HKD3_k127_4966218_20	265072.Mfla_2281	8.33e-73	260.0	COG0313@1|root,COG0313@2|Bacteria,1MU0E@1224|Proteobacteria,2VHI1@28216|Betaproteobacteria,2KKNX@206350|Nitrosomonadales	206350|Nitrosomonadales	H	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA	rsmI	-	2.1.1.198	ko:K07056	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TP_methylase
HKD3_k127_4966218_6	62928.azo3058	3.181e-193	609.0	COG0369@1|root,COG1149@1|root,COG0369@2|Bacteria,COG1149@2|Bacteria,1NCKQ@1224|Proteobacteria,2VIZE@28216|Betaproteobacteria,2KY3Q@206389|Rhodocyclales	206389|Rhodocyclales	C	Oxidoreductase NAD-binding domain	boxA	-	1.14.13.208	ko:K15511	ko00362,map00362	-	R09555	RC01739	ko00000,ko00001,ko01000	-	-	-	FAD_binding_6,Fer4,NAD_binding_1
HKD3_k127_4966218_2	381666.H16_B1913	3.716e-255	796.0	COG3396@1|root,COG3396@2|Bacteria,1MXUK@1224|Proteobacteria,2VH89@28216|Betaproteobacteria,1K485@119060|Burkholderiaceae	28216|Betaproteobacteria	S	benzoyl-CoA oxygenase	boxB	-	1.14.13.208	ko:K15512	ko00362,map00362	-	R09555	RC01739	ko00000,ko00001,ko01000	-	-	-	-
HKD3_k127_4966218_0	1217718.ALOU01000041_gene14	7.879e-261	816.0	COG1024@1|root,COG1024@2|Bacteria,1N817@1224|Proteobacteria,2VKSK@28216|Betaproteobacteria	28216|Betaproteobacteria	I	enoyl-CoA hydratase	boxC	-	4.1.2.44	ko:K15513	ko00362,map00362	-	R09556	RC03426	ko00000,ko00001,ko01000	-	-	-	ECH_1
HKD3_k127_4966218_14	62928.azo3055	4.328e-103	344.0	COG0703@1|root,COG1476@1|root,COG0703@2|Bacteria,COG1476@2|Bacteria,1MX66@1224|Proteobacteria,2VK91@28216|Betaproteobacteria,2KYAV@206389|Rhodocyclales	206389|Rhodocyclales	F	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate	boxR	-	-	ko:K15546	-	-	-	-	ko00000,ko03000	-	-	-	HTH_31,SKI
HKD3_k127_4966218_23	62928.azo3053	3.4e-56	200.0	294JI@1|root,2ZRZ3@2|Bacteria,1REGD@1224|Proteobacteria,2VRDG@28216|Betaproteobacteria,2KYGP@206389|Rhodocyclales	206389|Rhodocyclales	S	Domain of unknown function (DUF4863)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4863
HKD3_k127_4966218_4	62928.azo3052	2.452e-242	759.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2VJJS@28216|Betaproteobacteria,2KY7V@206389|Rhodocyclales	206389|Rhodocyclales	I	AMP-binding enzyme C-terminal domain	-	-	6.2.1.25	ko:K04110	ko00362,ko00627,ko01100,ko01120,map00362,map00627,map01100,map01120	-	R01422	RC00004,RC00174	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C
HKD3_k127_4966218_7	76114.ebA5303	2.142e-178	567.0	COG0683@1|root,COG0683@2|Bacteria,1MVV2@1224|Proteobacteria,2VIK5@28216|Betaproteobacteria,2KY62@206389|Rhodocyclales	28216|Betaproteobacteria	E	Extracellular ligand-binding receptor	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
HKD3_k127_4966218_10	76114.ebA5304	3.654e-136	439.0	COG0559@1|root,COG0559@2|Bacteria,1MVND@1224|Proteobacteria,2VK6C@28216|Betaproteobacteria,2KXZ1@206389|Rhodocyclales	206389|Rhodocyclales	U	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HKD3_k127_4966218_11	62928.azo3048	4.801e-117	394.0	COG4177@1|root,COG4177@2|Bacteria,1MUPI@1224|Proteobacteria,2VK9Y@28216|Betaproteobacteria,2KV1M@206389|Rhodocyclales	206389|Rhodocyclales	U	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HKD3_k127_4966218_15	76114.ebA5307	2.106e-99	331.0	COG0411@1|root,COG0411@2|Bacteria,1MXHT@1224|Proteobacteria,2VKUM@28216|Betaproteobacteria,2KY9I@206389|Rhodocyclales	206389|Rhodocyclales	E	ABC transporter	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
HKD3_k127_4966218_12	76114.ebA5309	3.289e-113	372.0	COG0410@1|root,COG0410@2|Bacteria,1MVYI@1224|Proteobacteria,2VHGT@28216|Betaproteobacteria,2KZYM@206389|Rhodocyclales	206389|Rhodocyclales	E	ABC transporter	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
HKD3_k127_4966218_16	748247.AZKH_4508	9.998e-98	327.0	COG2267@1|root,COG2267@2|Bacteria,1NK3M@1224|Proteobacteria,2VKPD@28216|Betaproteobacteria,2KZW8@206389|Rhodocyclales	206389|Rhodocyclales	I	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
HKD3_k127_4966218_28	196367.JNFG01000008_gene6478	3.996e-40	164.0	COG0824@1|root,COG0824@2|Bacteria,1MZPN@1224|Proteobacteria,2VTCV@28216|Betaproteobacteria,1K82U@119060|Burkholderiaceae	28216|Betaproteobacteria	S	thioesterase	-	-	3.1.2.23	ko:K01075	ko00130,ko00362,ko01100,ko01110,ko01120,map00130,map00362,map01100,map01110,map01120	-	R01301	RC00004,RC00174	ko00000,ko00001,ko01000	-	-	-	4HBT,4HBT_2
HKD3_k127_4966218_32	316055.RPE_0600	3.535e-31	135.0	COG1633@1|root,COG1633@2|Bacteria,1RJFW@1224|Proteobacteria,2U6JY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Rubrerythrin	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
HKD3_k127_4966218_21	85643.Tmz1t_2956	3.081e-67	231.0	COG1013@1|root,COG1013@2|Bacteria,1R5BF@1224|Proteobacteria,2VIQM@28216|Betaproteobacteria,2KY5Y@206389|Rhodocyclales	206389|Rhodocyclales	C	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
HKD3_k127_5030070_8	46429.BV95_03044	2.092e-13	78.0	COG5430@1|root,COG5430@2|Bacteria,1N5AX@1224|Proteobacteria,2UD10@28211|Alphaproteobacteria,2K70Q@204457|Sphingomonadales	204457|Sphingomonadales	S	Spore Coat Protein U domain	-	-	-	-	-	-	-	-	-	-	-	-	SCPU
HKD3_k127_5030070_4	342113.DM82_2224	6.095e-124	426.0	COG3188@1|root,COG3188@2|Bacteria,1MWV6@1224|Proteobacteria,2VIR3@28216|Betaproteobacteria,1K5T7@119060|Burkholderiaceae	28216|Betaproteobacteria	NU	Outer membrane usher protein	-	-	-	ko:K07347	ko05133,map05133	-	-	-	ko00000,ko00001,ko02000,ko02035,ko02044	1.B.11.3	-	-	PapC_C,Usher
HKD3_k127_5030070_7	1157708.KB907473_gene1236	5.527e-22	105.0	COG3121@1|root,COG3121@2|Bacteria,1R4RJ@1224|Proteobacteria,2VVAN@28216|Betaproteobacteria,4AJKD@80864|Comamonadaceae	28216|Betaproteobacteria	NU	Pili and flagellar-assembly chaperone, PapD N-terminal domain	-	-	-	ko:K07346	-	-	-	-	ko00000,ko02035,ko02044,ko03110	-	-	-	PapD_N
HKD3_k127_5030070_9	243233.MCA0306	0.0001904	52.0	COG5430@1|root,COG5430@2|Bacteria	2|Bacteria	S	Spore Coat Protein U domain	-	-	-	-	-	-	-	-	-	-	-	-	SCPU
HKD3_k127_5030070_3	365046.Rta_05270	1.491e-138	461.0	COG0820@1|root,COG0820@2|Bacteria,1Q0HH@1224|Proteobacteria,2VMGJ@28216|Betaproteobacteria,4AB6S@80864|Comamonadaceae	28216|Betaproteobacteria	H	Belongs to the radical SAM superfamily. RlmN family	rlmN_2	-	2.1.1.192	ko:K06941	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Fer4_14,Radical_SAM
HKD3_k127_5030070_2	296591.Bpro_0275	2.397e-149	484.0	COG0508@1|root,COG0508@2|Bacteria,1MU7K@1224|Proteobacteria,2VKC1@28216|Betaproteobacteria,4ABYH@80864|Comamonadaceae	28216|Betaproteobacteria	C	e3 binding domain	bkdB	-	2.3.1.168	ko:K09699	ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130	M00036	R02662,R03174,R04097,R10998	RC00004,RC02727,RC02870	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
HKD3_k127_5030070_1	296591.Bpro_0274	1.849e-186	612.0	COG0022@1|root,COG0022@2|Bacteria,1R8KB@1224|Proteobacteria,2VKQ0@28216|Betaproteobacteria,4ACZ7@80864|Comamonadaceae	28216|Betaproteobacteria	C	Transketolase, C-terminal domain	bkdA2	-	1.2.4.4	ko:K00167	ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130	M00036	R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00027,RC00627,RC02743,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
HKD3_k127_5030070_0	1007105.PT7_0836	9.496e-190	618.0	COG1071@1|root,COG1071@2|Bacteria,1MU5R@1224|Proteobacteria,2VNZH@28216|Betaproteobacteria,3T37T@506|Alcaligenaceae	28216|Betaproteobacteria	C	Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit	bkdA1	-	1.2.4.4	ko:K00166	ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130	M00036	R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00027,RC00627,RC02743,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh,OxoDH_E1alpha_N
HKD3_k127_5030070_6	767817.Desgi_1128	3.701e-104	361.0	COG1013@1|root,COG1013@2|Bacteria,1TPF0@1239|Firmicutes,24BE5@186801|Clostridia,261RJ@186807|Peptococcaceae	186801|Clostridia	C	PFAM Thiamine pyrophosphate enzyme, C-terminal TPP binding domain	-	-	1.2.7.1	ko:K00170	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
HKD3_k127_5030070_5	767817.Desgi_1127	2.939e-121	395.0	COG0674@1|root,COG0674@2|Bacteria,1VS48@1239|Firmicutes,25E5U@186801|Clostridia,261NS@186807|Peptococcaceae	186801|Clostridia	C	2-oxoacid ferredoxin oxidoreductase, alpha subunit	porA	GO:0003674,GO:0003824,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016054,GO:0016491,GO:0016625,GO:0016903,GO:0019752,GO:0033609,GO:0033611,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0055114,GO:0071704,GO:1901575	1.2.7.1,1.2.7.10	ko:K00169,ko:K19070	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
HKD3_k127_5076155_7	28444.JODQ01000002_gene3978	4.498e-07	53.0	COG0793@1|root,COG4946@1|root,COG0793@2|Bacteria,COG4946@2|Bacteria,2GJKW@201174|Actinobacteria,4EIAC@85012|Streptosporangiales	201174|Actinobacteria	M	Tricorn protease C1 domain	-	-	-	ko:K08676	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PD40,Peptidase_S41,Tricorn_C1,Tricorn_PDZ
HKD3_k127_5076155_5	640081.Dsui_1146	3.261e-77	282.0	COG2042@1|root,COG3376@2|Bacteria,1MUYH@1224|Proteobacteria,2VJDC@28216|Betaproteobacteria,2KYK1@206389|Rhodocyclales	206389|Rhodocyclales	P	High-affinity nickel-transport protein	-	-	-	ko:K07241	-	-	-	-	ko00000,ko02000	2.A.52.1	-	-	NicO
HKD3_k127_5076155_2	1121033.AUCF01000038_gene623	4.424e-146	470.0	COG2084@1|root,COG2084@2|Bacteria,1MUGU@1224|Proteobacteria,2TT50@28211|Alphaproteobacteria,2JQ2Q@204441|Rhodospirillales	204441|Rhodospirillales	I	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_11,NAD_binding_2
HKD3_k127_5076155_4	257310.BB2000	1.422e-82	281.0	COG3836@1|root,COG3836@2|Bacteria,1MUSG@1224|Proteobacteria,2VJFT@28216|Betaproteobacteria	28216|Betaproteobacteria	G	Belongs to the HpcH HpaI aldolase family	garL	-	4.1.2.20	ko:K01630	ko00053,map00053	-	R02754,R03277	RC00307,RC00435	ko00000,ko00001,ko01000	-	-	-	HpcH_HpaI
HKD3_k127_5076155_0	204773.HEAR0417	4.076e-244	761.0	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2VHKU@28216|Betaproteobacteria,4729F@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter TctA family	tctA4	-	-	ko:K07793	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctA
HKD3_k127_5076155_6	394.NGR_c26350	9.403e-46	170.0	29717@1|root,2ZU9N@2|Bacteria,1RJ7P@1224|Proteobacteria,2U5KG@28211|Alphaproteobacteria,4BG6H@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter TctB family	-	-	-	-	-	-	-	-	-	-	-	-	TctB
HKD3_k127_5076155_1	944435.AXAJ01000005_gene3652	8.296e-238	741.0	COG4948@1|root,COG4948@2|Bacteria,1NAKW@1224|Proteobacteria,2VIQ3@28216|Betaproteobacteria,1K3Z1@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Belongs to the mandelate racemase muconate lactonizing enzyme family	gudD	-	4.2.1.40	ko:K01706	ko00053,ko01100,map00053,map01100	-	R02752,R08056	RC00543	ko00000,ko00001,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
HKD3_k127_5076155_3	1095769.CAHF01000021_gene912	2.219e-141	452.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VHK8@28216|Betaproteobacteria,4731A@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HKD3_k127_5089958_3	243231.GSU0450	8.577e-35	139.0	COG1806@1|root,COG1806@2|Bacteria,1MUHU@1224|Proteobacteria,42RV7@68525|delta/epsilon subdivisions,2WNZT@28221|Deltaproteobacteria,43T28@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation	-	-	2.7.11.33,2.7.4.28	ko:K09773	-	-	-	-	ko00000,ko01000	-	-	-	Kinase-PPPase
HKD3_k127_5089958_4	748247.AZKH_0666	4.51e-19	92.0	COG3024@1|root,COG3024@2|Bacteria,1NGJ8@1224|Proteobacteria,2VXRV@28216|Betaproteobacteria,2KXJH@206389|Rhodocyclales	206389|Rhodocyclales	S	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase	yacG	-	-	ko:K09862	-	-	-	-	ko00000	-	-	-	YacG
HKD3_k127_5089958_2	265072.Mfla_2230	2.544e-94	325.0	COG0352@1|root,COG0494@1|root,COG0352@2|Bacteria,COG0494@2|Bacteria,1RCZM@1224|Proteobacteria,2VHTP@28216|Betaproteobacteria,2KM02@206350|Nitrosomonadales	206350|Nitrosomonadales	HL	Thiamine monophosphate synthase	-	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX,TMP-TENI
HKD3_k127_5089958_1	640081.Dsui_1060	6.796e-116	380.0	COG2607@1|root,COG2607@2|Bacteria,1MVMX@1224|Proteobacteria,2VID5@28216|Betaproteobacteria,2KUQI@206389|Rhodocyclales	206389|Rhodocyclales	S	ATPase (AAA	-	-	-	ko:K06923	-	-	-	-	ko00000	-	-	-	DUF815
HKD3_k127_5089958_0	987059.RBXJA2T_07005	3.591e-151	486.0	COG1364@1|root,COG1364@2|Bacteria,1MU0T@1224|Proteobacteria,2VJ84@28216|Betaproteobacteria,1KJ4N@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate	argJ	-	2.3.1.1,2.3.1.35	ko:K00620	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259,R02282	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	ArgJ
HKD3_k127_5095856_0	1230476.C207_05607	6.406e-244	760.0	COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,2TQU2@28211|Alphaproteobacteria,3JW1N@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	ko:K09456	-	-	-	-	ko00000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M
HKD3_k127_5095856_1	1286093.C266_24073	1.406e-201	669.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2VI0I@28216|Betaproteobacteria,1K4G7@119060|Burkholderiaceae	28216|Betaproteobacteria	IQ	PFAM AMP-dependent synthetase and ligase	fadD	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
HKD3_k127_5146239_10	1122951.ATUE01000009_gene418	1.05e-85	289.0	COG4147@1|root,COG4147@2|Bacteria,1MVJ8@1224|Proteobacteria,1RN0R@1236|Gammaproteobacteria,3NJC9@468|Moraxellaceae	1236|Gammaproteobacteria	S	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	actP	-	-	ko:K14393	-	-	-	-	ko00000,ko02000	2.A.21.7	-	-	SSF
HKD3_k127_5146239_4	159087.Daro_1635	6.762e-166	542.0	COG2905@1|root,COG2905@2|Bacteria,1MW8U@1224|Proteobacteria,2VHE1@28216|Betaproteobacteria,2KVCU@206389|Rhodocyclales	206389|Rhodocyclales	T	signal-transduction protein containing cAMP-binding and CBS domains	-	-	-	ko:K07182	-	-	-	-	ko00000	-	-	-	CBS,DUF294,DUF294_C,cNMP_binding
HKD3_k127_5146239_13	296591.Bpro_4148	8.132e-15	77.0	2DNR5@1|root,32YQH@2|Bacteria,1NBXJ@1224|Proteobacteria,2VW7K@28216|Betaproteobacteria,4AIUC@80864|Comamonadaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_5146239_0	296591.Bpro_4149	0.0	1150.0	COG0591@1|root,COG0642@1|root,COG0591@2|Bacteria,COG2205@2|Bacteria,1MUY7@1224|Proteobacteria,2VKRS@28216|Betaproteobacteria,4AAXQ@80864|Comamonadaceae	28216|Betaproteobacteria	T	His Kinase A (phospho-acceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_7,Response_reg
HKD3_k127_5146239_12	1318628.MARLIPOL_05410	1.382e-50	181.0	COG0745@1|root,COG0745@2|Bacteria,1RHCU@1224|Proteobacteria,1SBB6@1236|Gammaproteobacteria,46B2G@72275|Alteromonadaceae	1236|Gammaproteobacteria	KT	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
HKD3_k127_5146239_1	748247.AZKH_1723	1.67e-237	754.0	COG2176@1|root,COG5002@1|root,COG2176@2|Bacteria,COG5002@2|Bacteria,1QUVW@1224|Proteobacteria,2VHZ3@28216|Betaproteobacteria,2KUQR@206389|Rhodocyclales	206389|Rhodocyclales	L	DNA polymerase III	-	-	2.7.7.7	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	RNase_T
HKD3_k127_5146239_9	1121106.JQKB01000003_gene2472	2.013e-105	379.0	COG0411@1|root,COG0411@2|Bacteria,1MX51@1224|Proteobacteria,2TTCE@28211|Alphaproteobacteria,2JQIS@204441|Rhodospirillales	204441|Rhodospirillales	E	Branched-chain amino acid ATP-binding cassette transporter	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
HKD3_k127_5146239_8	1211115.ALIQ01000237_gene2514	3.009e-118	386.0	COG0410@1|root,COG0410@2|Bacteria,1MUR3@1224|Proteobacteria,2TSWQ@28211|Alphaproteobacteria,3NC02@45404|Beijerinckiaceae	28211|Alphaproteobacteria	E	ATPases associated with a variety of cellular activities	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
HKD3_k127_5146239_3	1100720.ALKN01000033_gene730	7.43e-193	609.0	COG0683@1|root,COG0683@2|Bacteria,1MUCB@1224|Proteobacteria,2VHXC@28216|Betaproteobacteria,4AB9R@80864|Comamonadaceae	28216|Betaproteobacteria	E	Extracellular ligand-binding receptor	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
HKD3_k127_5146239_6	1211115.ALIQ01000237_gene2512	3.707e-143	458.0	COG0559@1|root,COG0559@2|Bacteria,1MY1E@1224|Proteobacteria,2TSIQ@28211|Alphaproteobacteria,3NCAE@45404|Beijerinckiaceae	28211|Alphaproteobacteria	E	Branched-chain amino acid transport system / permease component	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HKD3_k127_5146239_7	1380394.JADL01000003_gene5079	7.057e-140	451.0	COG4177@1|root,COG4177@2|Bacteria,1MWP3@1224|Proteobacteria,2TR99@28211|Alphaproteobacteria,2JPQ6@204441|Rhodospirillales	204441|Rhodospirillales	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HKD3_k127_5146239_14	1121352.JHZP01000001_gene551	4.141e-06	57.0	COG2849@1|root,COG2849@2|Bacteria,1RJZH@1224|Proteobacteria,2VT1T@28216|Betaproteobacteria,2KRHY@206351|Neisseriales	206351|Neisseriales	S	MORN repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	MORN_2
HKD3_k127_5146239_2	977880.RALTA_A2753	2.703e-193	618.0	COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,2VHCV@28216|Betaproteobacteria,1K2J1@119060|Burkholderiaceae	28216|Betaproteobacteria	E	ABC transporter substrate-binding protein	dppA2	-	-	ko:K02035,ko:K13889	ko02010,ko02024,map02010,map02024	M00239,M00348	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.11	-	-	SBP_bac_5
HKD3_k127_5146239_5	296591.Bpro_2531	9.764e-151	482.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2VHEF@28216|Betaproteobacteria,4ACHP@80864|Comamonadaceae	28216|Betaproteobacteria	P	PFAM binding-protein-dependent transport systems inner membrane component	dppB2	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
HKD3_k127_5146239_11	1380394.JADL01000010_gene4344	1.068e-62	222.0	COG1173@1|root,COG1173@2|Bacteria,1MUG0@1224|Proteobacteria,2TT4V@28211|Alphaproteobacteria,2JPM9@204441|Rhodospirillales	204441|Rhodospirillales	EP	N-terminal TM domain of oligopeptide transport permease C	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
HKD3_k127_5150871_1	243365.CV_1598	2.87e-294	917.0	COG2216@1|root,COG2216@2|Bacteria,1MU7D@1224|Proteobacteria,2VH26@28216|Betaproteobacteria,2KQUA@206351|Neisseriales	206351|Neisseriales	P	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system	kdpB	-	3.6.3.12	ko:K01547	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	3.A.3.7	-	-	E1-E2_ATPase,Hydrolase
HKD3_k127_5150871_2	1116472.MGMO_14c00060	3.377e-258	810.0	COG2060@1|root,COG2060@2|Bacteria,1MV1K@1224|Proteobacteria,1RQZU@1236|Gammaproteobacteria,1XE95@135618|Methylococcales	135618|Methylococcales	P	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane	kdpA	-	3.6.3.12	ko:K01546	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	3.A.3.7	-	-	KdpA
HKD3_k127_5150871_4	522306.CAP2UW1_1683	4.658e-231	730.0	COG3158@1|root,COG3158@2|Bacteria,1MUVH@1224|Proteobacteria,2VH9I@28216|Betaproteobacteria,1KQJR@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	P	Transport of potassium into the cell	kup	-	-	ko:K03549	-	-	-	-	ko00000,ko02000	2.A.72	-	-	K_trans
HKD3_k127_5150871_11	640081.Dsui_3151	8.367e-79	276.0	COG0745@1|root,COG0745@2|Bacteria,1MWZ5@1224|Proteobacteria,2VKBW@28216|Betaproteobacteria,2KYJA@206389|Rhodocyclales	206389|Rhodocyclales	T	Transcriptional regulatory protein, C terminal	-	-	-	ko:K07667	ko02020,ko02024,map02020,map02024	M00454	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
HKD3_k127_5150871_9	1538295.JY96_15880	8.959e-119	404.0	COG0642@1|root,COG2205@2|Bacteria,1MUZQ@1224|Proteobacteria,2VH62@28216|Betaproteobacteria,1KKH3@119065|unclassified Burkholderiales	28216|Betaproteobacteria	T	Histidine kinase	kdpD	-	2.7.13.3	ko:K07646	ko02020,map02020	M00454	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	DUF4118,GAF_3,HATPase_c,HisKA,KdpD
HKD3_k127_5150871_16	1380394.JADL01000011_gene3787	8.682e-53	192.0	COG0715@1|root,COG0715@2|Bacteria,1MWJF@1224|Proteobacteria,2TT19@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	-	-	-	-	-	-	-	-	-	NMT1_2
HKD3_k127_5150871_12	1504672.669787190	1.02e-70	259.0	COG1538@1|root,COG1538@2|Bacteria,1NW1T@1224|Proteobacteria,2VQKM@28216|Betaproteobacteria,4AEPD@80864|Comamonadaceae	28216|Betaproteobacteria	MU	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
HKD3_k127_5150871_7	1502852.FG94_03266	1.543e-147	499.0	COG0845@1|root,COG5569@1|root,COG0845@2|Bacteria,COG5569@2|Bacteria,1MVAS@1224|Proteobacteria,2VJXV@28216|Betaproteobacteria,473WK@75682|Oxalobacteraceae	28216|Betaproteobacteria	M	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	cusB	-	-	ko:K07798	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4,8.A.1	-	-	CusF_Ec,HlyD_D23,HlyD_D4
HKD3_k127_5150871_0	1198452.Jab_2c03860	0.0	1512.0	COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,2VHCZ@28216|Betaproteobacteria,4766G@75682|Oxalobacteraceae	28216|Betaproteobacteria	P	AcrB/AcrD/AcrF family	cusA	-	-	ko:K07787	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4	-	-	ACR_tran
HKD3_k127_5150871_26	909663.KI867150_gene1525	7.005e-07	54.0	COG1977@1|root,COG1977@2|Bacteria,1NH6M@1224|Proteobacteria,42X05@68525|delta/epsilon subdivisions,2WSK5@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	PFAM thiamineS protein	-	-	-	-	-	-	-	-	-	-	-	-	ThiS,Ub-Mut7C
HKD3_k127_5150871_10	1454004.AW11_02870	1.5e-87	308.0	COG1251@1|root,COG1251@2|Bacteria,1MW58@1224|Proteobacteria,2WH5F@28216|Betaproteobacteria	28216|Betaproteobacteria	C	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2
HKD3_k127_5150871_5	243231.GSU0910	3.705e-191	623.0	COG2414@1|root,COG2414@2|Bacteria,1MWBB@1224|Proteobacteria,42NR7@68525|delta/epsilon subdivisions,2WK49@28221|Deltaproteobacteria,43SV4@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Aldehyde ferredoxin oxidoreductase, N-terminal domain	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
HKD3_k127_5150871_17	1123355.JHYO01000030_gene359	1.16e-50	195.0	COG1142@1|root,COG1142@2|Bacteria,1QWC6@1224|Proteobacteria,2TXIR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	4Fe-4S dicluster domain	-	-	-	ko:K00196,ko:K05796	ko00633,ko00680,ko00720,ko01120,ko01200,map00633,map00680,map00720,map01120,map01200	-	R07157,R08034	RC00250,RC02800	ko00000,ko00001	-	-	-	Fer4_4,Fer4_9
HKD3_k127_5150871_14	316274.Haur_3299	1.592e-61	239.0	COG2340@1|root,COG2340@2|Bacteria	2|Bacteria	S	peptidase inhibitor activity	-	-	3.4.17.14	ko:K07260	ko00550,ko01100,ko01502,ko02020,map00550,map01100,map01502,map02020	M00651	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504	-	-	-	CAP,HemolysinCabind,LGFP,VanY
HKD3_k127_5150871_23	323261.Noc_2169	4.413e-16	93.0	COG1404@1|root,COG1404@2|Bacteria,1RDZC@1224|Proteobacteria,1S91S@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
HKD3_k127_5150871_18	522306.CAP2UW1_3355	1.184e-44	171.0	COG1396@1|root,COG1396@2|Bacteria,1R0QM@1224|Proteobacteria	1224|Proteobacteria	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_5150871_3	266264.Rmet_5795	4.159e-248	796.0	COG1297@1|root,COG1297@2|Bacteria,1NQQP@1224|Proteobacteria	1224|Proteobacteria	S	OPT oligopeptide transporter protein	-	-	-	-	-	-	-	-	-	-	-	-	OPT
HKD3_k127_5150871_6	1031711.RSPO_c01316	1.612e-148	481.0	COG0726@1|root,COG0726@2|Bacteria,1MV3V@1224|Proteobacteria,2VJQR@28216|Betaproteobacteria,1K1KN@119060|Burkholderiaceae	28216|Betaproteobacteria	G	PFAM polysaccharide deacetylase	-	-	3.5.1.41	ko:K01452	ko00520,ko01100,map00520,map01100	-	R02333	RC00166,RC00300	ko00000,ko00001,ko01000	-	-	-	Polysacc_deac_1
HKD3_k127_5150871_19	342113.DM82_1664	1.141e-40	169.0	COG2351@1|root,COG2351@2|Bacteria,1RH84@1224|Proteobacteria,2VUG8@28216|Betaproteobacteria,1K7R7@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily	uraH	-	3.5.2.17	ko:K07127	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R06601	RC03393	ko00000,ko00001,ko00002,ko01000,ko02000	9.B.35.1.2,9.B.35.2	-	-	Transthyretin
HKD3_k127_5150871_8	1349767.GJA_4389	8.966e-142	462.0	COG3748@1|root,COG3748@2|Bacteria,1MWHB@1224|Proteobacteria,2VIC0@28216|Betaproteobacteria,473XM@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Urate oxidase N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	Urate_ox_N
HKD3_k127_5150871_13	1089551.KE386572_gene2348	1.312e-68	246.0	COG2135@1|root,COG2135@2|Bacteria,1RER4@1224|Proteobacteria,2U0W2@28211|Alphaproteobacteria,4BQ4Z@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	SOS response associated peptidase (SRAP)	MA20_42060	-	-	-	-	-	-	-	-	-	-	-	SRAP
HKD3_k127_5150871_20	338969.Rfer_2035	1.456e-35	152.0	2A5P5@1|root,30UDZ@2|Bacteria,1RHAP@1224|Proteobacteria,2W2M6@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_5150871_21	375286.mma_3255	1.764e-30	126.0	COG5615@1|root,COG5615@2|Bacteria,1N3BK@1224|Proteobacteria,2VQHM@28216|Betaproteobacteria,47900@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Copper resistance protein D	-	-	-	-	-	-	-	-	-	-	-	-	CopD
HKD3_k127_5150871_15	1000565.METUNv1_02803	1.679e-59	210.0	COG1763@1|root,COG1763@2|Bacteria,1RD3Q@1224|Proteobacteria,2VSIP@28216|Betaproteobacteria,2KWDE@206389|Rhodocyclales	206389|Rhodocyclales	H	molybdopterin-guanine dinucleotide biosynthesis protein	-	-	-	ko:K03753	-	-	-	-	ko00000	-	-	-	MobB
HKD3_k127_5150871_25	1122604.JONR01000008_gene2201	4.302e-07	60.0	COG2885@1|root,COG3637@1|root,COG2885@2|Bacteria,COG3637@2|Bacteria,1N4RD@1224|Proteobacteria,1S9YV@1236|Gammaproteobacteria,1X6RP@135614|Xanthomonadales	135614|Xanthomonadales	JM	OmpA family	-	-	-	-	-	-	-	-	-	-	-	-	OmpA,SmpA_OmlA
HKD3_k127_5150871_22	1095769.CAHF01000010_gene1266	9.766e-18	86.0	COG1977@1|root,COG1977@2|Bacteria,1N0IE@1224|Proteobacteria,2VVSP@28216|Betaproteobacteria,474XC@75682|Oxalobacteraceae	28216|Betaproteobacteria	H	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin	moaD	-	-	ko:K03636	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
HKD3_k127_5222667_1	215803.DB30_6542	5.074e-54	194.0	COG0500@1|root,COG2226@2|Bacteria,1RC36@1224|Proteobacteria,42UDA@68525|delta/epsilon subdivisions,2WQHW@28221|Deltaproteobacteria,2YV8X@29|Myxococcales	28221|Deltaproteobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
HKD3_k127_5222667_0	580332.Slit_2241	0.0	1287.0	COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,2VH3Q@28216|Betaproteobacteria,44WDB@713636|Nitrosomonadales	28216|Betaproteobacteria	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	nrdJ	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_lgC,Ribonuc_red_lgN
HKD3_k127_5227247_0	1265502.KB905937_gene2591	4.904e-103	339.0	COG0018@1|root,COG0018@2|Bacteria,1MU4J@1224|Proteobacteria,2VHT1@28216|Betaproteobacteria,4AACX@80864|Comamonadaceae	28216|Betaproteobacteria	J	Arginyl-tRNA synthetase	argS	-	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
HKD3_k127_5227247_5	1454004.AW11_01996	8.342e-25	115.0	COG3087@1|root,COG3087@2|Bacteria,1RI6A@1224|Proteobacteria,2VR10@28216|Betaproteobacteria,1KR3V@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	D	Sporulation related domain	ftsN	-	-	-	-	-	-	-	-	-	-	-	SPOR
HKD3_k127_5227247_3	765912.Thimo_2969	8.089e-48	191.0	COG1651@1|root,COG1651@2|Bacteria,1RGWH@1224|Proteobacteria,1S5WA@1236|Gammaproteobacteria,1WY1E@135613|Chromatiales	135613|Chromatiales	O	Thiol disulfide interchange protein	-	-	-	ko:K03673	ko01503,map01503	M00728	-	-	ko00000,ko00001,ko00002,ko03110	-	-	-	DSBA
HKD3_k127_5227247_1	62928.azo0383	5.245e-95	318.0	COG4221@1|root,COG4221@2|Bacteria,1QTVZ@1224|Proteobacteria,2WGPF@28216|Betaproteobacteria,2KZNP@206389|Rhodocyclales	206389|Rhodocyclales	S	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HKD3_k127_5227247_2	1348657.M622_00525	2.025e-74	279.0	COG4558@1|root,COG4558@2|Bacteria,1QVI8@1224|Proteobacteria,2WGSH@28216|Betaproteobacteria,2KURN@206389|Rhodocyclales	206389|Rhodocyclales	P	COG0614 ABC-type Fe3 -hydroxamate transport system, periplasmic component	-	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_2
HKD3_k127_5227247_4	1005048.CFU_1690	1.304e-34	141.0	COG3240@1|root,COG4625@1|root,COG3240@2|Bacteria,COG4625@2|Bacteria,1MWDI@1224|Proteobacteria,2WEDW@28216|Betaproteobacteria	28216|Betaproteobacteria	I	Autotransporter beta-domain	-	-	-	ko:K12686	-	-	-	-	ko00000,ko02000,ko02044	1.B.12.8	-	-	Autotransporter,Lipase_GDSL
HKD3_k127_5325994_3	697281.Mahau_0035	2.003e-49	181.0	COG0454@1|root,COG0456@2|Bacteria,1VCET@1239|Firmicutes,24MTN@186801|Clostridia	186801|Clostridia	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HKD3_k127_5325994_1	76114.ebA2304	1.725e-108	362.0	COG1741@1|root,COG1741@2|Bacteria,1MWIP@1224|Proteobacteria,2VHUJ@28216|Betaproteobacteria,2KWM7@206389|Rhodocyclales	206389|Rhodocyclales	S	Belongs to the pirin family	-	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin,Pirin_C
HKD3_k127_5325994_4	643562.Daes_1725	1.007e-08	62.0	COG0348@1|root,COG0348@2|Bacteria,1R4WT@1224|Proteobacteria,42NQI@68525|delta/epsilon subdivisions,2WKGR@28221|Deltaproteobacteria,2M7YW@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	PFAM 4Fe-4S ferredoxin iron-sulfur binding	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_5,Fer4_9
HKD3_k127_5325994_2	331869.BAL199_03999	2.805e-87	302.0	COG0329@1|root,COG0329@2|Bacteria,1Q9QM@1224|Proteobacteria,2VA01@28211|Alphaproteobacteria,4BRSS@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	EM	Dihydrodipicolinate synthetase family	-	-	-	-	-	-	-	-	-	-	-	-	DHDPS
HKD3_k127_5325994_0	1454004.AW11_00535	7.279e-109	367.0	COG2267@1|root,COG2267@2|Bacteria,1QTZP@1224|Proteobacteria,2VKTF@28216|Betaproteobacteria	28216|Betaproteobacteria	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6,Hydrolase_4
HKD3_k127_5346455_14	977880.RALTA_B1715	2.292e-21	105.0	COG2207@1|root,COG2207@2|Bacteria	2|Bacteria	K	Transcriptional regulator	-	-	-	ko:K04033	-	-	-	-	ko00000,ko03000	-	-	-	HTH_18
HKD3_k127_5346455_8	1000565.METUNv1_02770	3.102e-89	297.0	COG0231@1|root,COG0231@2|Bacteria,1MW2J@1224|Proteobacteria,2VH4A@28216|Betaproteobacteria,2KVAS@206389|Rhodocyclales	206389|Rhodocyclales	J	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase	efp	-	-	ko:K02356	-	-	-	-	ko00000,ko03012	-	-	-	EFP,EFP_N,Elong-fact-P_C
HKD3_k127_5346455_5	76114.ebA2974	2.991e-100	341.0	COG4394@1|root,COG4394@2|Bacteria,1MYVF@1224|Proteobacteria,2VHIB@28216|Betaproteobacteria,2KU6H@206389|Rhodocyclales	206389|Rhodocyclales	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF2331
HKD3_k127_5346455_11	1122929.KB908236_gene388	8.451e-56	203.0	COG2761@1|root,COG2761@2|Bacteria,1NXUB@1224|Proteobacteria,2TRJ6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	dithiol-disulfide isomerase involved in polyketide biosynthesis	dsb	-	-	-	-	-	-	-	-	-	-	-	DSBA
HKD3_k127_5346455_4	1163617.SCD_n00539	8.775e-106	352.0	COG0053@1|root,COG0053@2|Bacteria,1MUDS@1224|Proteobacteria,2VJ1J@28216|Betaproteobacteria	28216|Betaproteobacteria	P	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family	fieF	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,ZT_dimer
HKD3_k127_5346455_13	1173263.Syn7502_03599	5.907e-31	128.0	COG4319@1|root,COG4319@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_2
HKD3_k127_5346455_10	580332.Slit_2524	1.449e-58	233.0	COG1877@1|root,COG1877@2|Bacteria,1RGY2@1224|Proteobacteria,2VRQ8@28216|Betaproteobacteria	28216|Betaproteobacteria	G	Removes the phosphate from trehalose 6-phosphate to produce free trehalose	otsB	-	3.1.3.12	ko:K01087	ko00500,ko01100,map00500,map01100	-	R02778	RC00017	ko00000,ko00001,ko01000	-	-	-	Trehalose_PPase
HKD3_k127_5346455_0	243231.GSU2337	3.189e-299	937.0	COG0380@1|root,COG0380@2|Bacteria,1MUIY@1224|Proteobacteria,42NBU@68525|delta/epsilon subdivisions,2WJX9@28221|Deltaproteobacteria,43UCR@69541|Desulfuromonadales	28221|Deltaproteobacteria	G	Glycosyltransferase family 20	-	-	2.4.1.15,2.4.1.347	ko:K00697	ko00500,ko01100,map00500,map01100	-	R02737	RC00005,RC00049,RC02748	ko00000,ko00001,ko01000,ko01003	-	GT20	-	Glyco_transf_20
HKD3_k127_5346455_6	1235457.C404_21005	9.138e-93	315.0	COG0600@1|root,COG0600@2|Bacteria,1MVAE@1224|Proteobacteria,2VI9J@28216|Betaproteobacteria,1K591@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
HKD3_k127_5346455_7	441620.Mpop_1094	8.473e-91	307.0	COG1116@1|root,COG1116@2|Bacteria,1MUIM@1224|Proteobacteria,2TRHM@28211|Alphaproteobacteria,1JU5E@119045|Methylobacteriaceae	28211|Alphaproteobacteria	P	ABC transporter	-	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
HKD3_k127_5346455_3	1380387.JADM01000001_gene139	9.99e-114	375.0	COG0715@1|root,COG0715@2|Bacteria,1MXA3@1224|Proteobacteria,1RR27@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems, periplasmic components	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
HKD3_k127_5346455_2	644968.DFW101_1814	2.341e-165	532.0	COG0122@1|root,COG2169@1|root,COG0122@2|Bacteria,COG2169@2|Bacteria,1QTXM@1224|Proteobacteria,42N8C@68525|delta/epsilon subdivisions,2WM3N@28221|Deltaproteobacteria,2M812@213115|Desulfovibrionales	28221|Deltaproteobacteria	K	AlkA N-terminal domain	ada	-	3.2.2.21	ko:K13529,ko:K13530	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03000,ko03400	-	-	-	Ada_Zn_binding,AlkA_N,HTH_18,HhH-GPD
HKD3_k127_5346455_12	749927.AMED_4916	3.424e-48	179.0	COG0350@1|root,COG0350@2|Bacteria,2IHXW@201174|Actinobacteria,4E3JX@85010|Pseudonocardiales	201174|Actinobacteria	L	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated	ogt	GO:0003674,GO:0003824,GO:0003908,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006304,GO:0006307,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0009987,GO:0016020,GO:0016740,GO:0016741,GO:0032259,GO:0033554,GO:0034641,GO:0035510,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051409,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:1901360	2.1.1.63	ko:K00567	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_binding_1,Methyltransf_1N
HKD3_k127_5346455_9	502025.Hoch_1468	5.204e-67	246.0	COG0697@1|root,COG0697@2|Bacteria,1MZQM@1224|Proteobacteria,42VPN@68525|delta/epsilon subdivisions,2WRK6@28221|Deltaproteobacteria,2Z1WG@29|Myxococcales	28221|Deltaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HKD3_k127_5346455_15	861299.J421_5709	2.178e-16	92.0	COG0457@1|root,COG3629@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3629@2|Bacteria,COG5616@2|Bacteria	2|Bacteria	S	cAMP biosynthetic process	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	AAA_16,BTAD,TPR_12,TPR_16,Trans_reg_C
HKD3_k127_5346455_16	1036674.A28LD_1108	0.0002423	53.0	COG3710@1|root,COG3710@2|Bacteria,1R081@1224|Proteobacteria,1T4FU@1236|Gammaproteobacteria,2QGKF@267893|Idiomarinaceae	1236|Gammaproteobacteria	K	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Trans_reg_C
HKD3_k127_5346455_1	1122132.AQYH01000002_gene1283	1.91e-166	529.0	COG1574@1|root,COG1574@2|Bacteria,1MWP2@1224|Proteobacteria,2TTRU@28211|Alphaproteobacteria,4BAGU@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
HKD3_k127_5404345_11	596152.DesU5LDRAFT_0087	3.788e-73	259.0	COG3914@1|root,COG3914@2|Bacteria,1QU3U@1224|Proteobacteria,43CQC@68525|delta/epsilon subdivisions,2X7XP@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	Glycosyl transferase family 41	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_41
HKD3_k127_5404345_7	1163617.SCD_n01749	1.246e-122	417.0	COG1807@1|root,COG1807@2|Bacteria,1NMIZ@1224|Proteobacteria,2VMHK@28216|Betaproteobacteria	28216|Betaproteobacteria	M	PFAM glycosyl transferase family 39	arnT	-	-	-	-	-	-	-	-	-	-	-	PMT,PMT_2
HKD3_k127_5404345_15	522306.CAP2UW1_3297	3.129e-37	149.0	COG2076@1|root,COG2076@2|Bacteria,1RHUW@1224|Proteobacteria,2VSEI@28216|Betaproteobacteria	28216|Betaproteobacteria	P	Small multidrug resistance	-	-	-	-	-	-	-	-	-	-	-	-	EamA,Multi_Drug_Res
HKD3_k127_5404345_4	1198452.Jab_1c17650	2.499e-142	462.0	COG0399@1|root,COG0399@2|Bacteria,1MUPN@1224|Proteobacteria,2VJDZ@28216|Betaproteobacteria,472RC@75682|Oxalobacteraceae	28216|Betaproteobacteria	E	Belongs to the DegT DnrJ EryC1 family	arnB	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
HKD3_k127_5404345_5	1163617.SCD_n01752	1.909e-131	426.0	COG0463@1|root,COG0463@2|Bacteria,1MWE5@1224|Proteobacteria,2VJ5G@28216|Betaproteobacteria	28216|Betaproteobacteria	M	Pfam Glycosyl transferase family 2	arnC	-	2.4.2.53	ko:K10012	ko00520,ko01503,map00520,map01503	M00721,M00761	R07661	RC00005,RC02954	ko00000,ko00001,ko00002,ko01000,ko01005,ko02000	4.D.2.1.8	GT2	-	Glycos_transf_2
HKD3_k127_5404345_8	522306.CAP2UW1_3294	1.585e-117	388.0	COG0223@1|root,COG0223@2|Bacteria,1MWH1@1224|Proteobacteria,2VKAI@28216|Betaproteobacteria,1KQ9M@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	J	Formyl transferase, C-terminal domain	pmrIa	-	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	-	Formyl_trans_C,Formyl_trans_N
HKD3_k127_5404345_2	1158292.JPOE01000002_gene2806	2.999e-181	572.0	COG0451@1|root,COG0451@2|Bacteria,1MXKV@1224|Proteobacteria,2VJV2@28216|Betaproteobacteria,1KKIW@119065|unclassified Burkholderiales	28216|Betaproteobacteria	GM	NAD(P)H-binding	pmrIb	-	-	-	-	-	-	-	-	-	-	-	Epimerase
HKD3_k127_5404345_6	580332.Slit_1375	1.178e-122	420.0	COG0726@1|root,COG0726@2|Bacteria,1N8Q4@1224|Proteobacteria,2VKEP@28216|Betaproteobacteria,44VD4@713636|Nitrosomonadales	28216|Betaproteobacteria	G	Polysaccharide deacetylase	arnD	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
HKD3_k127_5404345_12	640081.Dsui_1997	5.749e-61	217.0	COG1225@1|root,COG1225@2|Bacteria,1RD4R@1224|Proteobacteria,2VR4P@28216|Betaproteobacteria,2KWEZ@206389|Rhodocyclales	206389|Rhodocyclales	O	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	-	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
HKD3_k127_5404345_9	76114.ebA6733	9.059e-115	400.0	COG0500@1|root,COG2226@2|Bacteria,1MXP4@1224|Proteobacteria,2VJM3@28216|Betaproteobacteria,2KUB0@206389|Rhodocyclales	206389|Rhodocyclales	H	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
HKD3_k127_5404345_3	522306.CAP2UW1_3052	8.241e-144	465.0	COG2207@1|root,COG2207@2|Bacteria,1PG77@1224|Proteobacteria,2W9CD@28216|Betaproteobacteria,1KQXQ@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	K	Cupin	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_6,HTH_18
HKD3_k127_5404345_1	1000565.METUNv1_00777	1.962e-228	728.0	COG1875@1|root,COG1875@2|Bacteria,1MUX1@1224|Proteobacteria,2VH4P@28216|Betaproteobacteria,2KUNN@206389|Rhodocyclales	206389|Rhodocyclales	T	ATPase related to phosphate starvation-inducible protein PhoH	-	-	-	ko:K07175	-	-	-	-	ko00000	-	-	-	PIN_4,PhoH
HKD3_k127_5404345_0	1205680.CAKO01000042_gene5367	2.17e-261	817.0	COG3119@1|root,COG3119@2|Bacteria,1MUJH@1224|Proteobacteria,2TSB8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	arylsulfatase A	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	DUF4994,Sulfatase,Sulfatase_C
HKD3_k127_5404345_14	95619.PM1_0221050	5.24e-44	173.0	COG0583@1|root,COG0583@2|Bacteria,1RJXD@1224|Proteobacteria,1SBA9@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HKD3_k127_5404345_10	1123487.KB892835_gene3635	3.137e-89	323.0	COG0642@1|root,COG0784@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,1MUY7@1224|Proteobacteria,2VIXT@28216|Betaproteobacteria,2KUH6@206389|Rhodocyclales	206389|Rhodocyclales	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	DUF2222,HAMP,HATPase_c,HisKA,Response_reg,dCache_1
HKD3_k127_5404345_16	1169143.KB911037_gene4227	9.545e-16	91.0	COG2909@1|root,COG3629@1|root,COG2909@2|Bacteria,COG3629@2|Bacteria,1MVZZ@1224|Proteobacteria,2VXDK@28216|Betaproteobacteria,1K5E1@119060|Burkholderiaceae	28216|Betaproteobacteria	K	Bacterial transcriptional activator domain	-	-	-	-	-	-	-	-	-	-	-	-	BTAD
HKD3_k127_5404345_13	543728.Vapar_0555	4.791e-46	176.0	COG2197@1|root,COG2197@2|Bacteria,1P4TD@1224|Proteobacteria,2VMX4@28216|Betaproteobacteria,4AEXS@80864|Comamonadaceae	28216|Betaproteobacteria	K	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HKD3_k127_5520725_22	1000565.METUNv1_02979	1.561e-86	287.0	COG0499@1|root,COG0499@2|Bacteria,1MUQ2@1224|Proteobacteria,2VH57@28216|Betaproteobacteria,2KVI2@206389|Rhodocyclales	206389|Rhodocyclales	H	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine	ahcY	-	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
HKD3_k127_5520725_23	675635.Psed_4311	1.972e-86	298.0	COG1893@1|root,COG1893@2|Bacteria,2I3AM@201174|Actinobacteria,4E3ZP@85010|Pseudonocardiales	201174|Actinobacteria	H	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid	-	-	1.1.1.169	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R02472	RC00726	ko00000,ko00001,ko00002,ko01000	-	-	-	ApbA,ApbA_C
HKD3_k127_5520725_38	375286.mma_3195	1.026e-35	151.0	COG1950@1|root,COG1950@2|Bacteria,1N1DF@1224|Proteobacteria,2VUY1@28216|Betaproteobacteria,474RA@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Mycobacterial 4 TMS phage holin, superfamily IV	-	-	-	ko:K08972	-	-	-	-	ko00000	-	-	-	Phage_holin_4_2
HKD3_k127_5520725_10	1454004.AW11_02826	1.649e-132	428.0	COG0685@1|root,COG0685@2|Bacteria,1MUC9@1224|Proteobacteria,2VHHI@28216|Betaproteobacteria,1KQDS@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	E	Methylenetetrahydrofolate reductase	metF	GO:0000166,GO:0003674,GO:0003824,GO:0004489,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016043,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0018130,GO:0019438,GO:0019752,GO:0022607,GO:0034641,GO:0036094,GO:0042398,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0048037,GO:0050660,GO:0050662,GO:0051186,GO:0051188,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:0071949,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	1.5.1.20	ko:K00297	ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523	M00377	R01224,R07168	RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	MTHFR
HKD3_k127_5520725_26	420324.KI911950_gene7040	1.527e-69	258.0	COG2518@1|root,COG2518@2|Bacteria,1MXQC@1224|Proteobacteria,2TVCY@28211|Alphaproteobacteria,1JU6D@119045|Methylobacteriaceae	28211|Alphaproteobacteria	J	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	pcm	-	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
HKD3_k127_5520725_47	75379.Tint_3144	2.316e-08	64.0	2EJ9A@1|root,33D0G@2|Bacteria,1NIDB@1224|Proteobacteria,2VYKW@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_5520725_41	314230.DSM3645_25684	8.357e-32	127.0	COG2076@1|root,COG2076@2|Bacteria,2J0PX@203682|Planctomycetes	2|Bacteria	P	of cations and cationic drugs	yvaE	-	-	ko:K03297	-	-	-	-	ko00000,ko02000	2.A.7.1	-	-	Multi_Drug_Res
HKD3_k127_5520725_44	1278073.MYSTI_01640	6.994e-18	94.0	COG2207@1|root,COG2207@2|Bacteria,1N17J@1224|Proteobacteria,433WR@68525|delta/epsilon subdivisions,2X3X8@28221|Deltaproteobacteria,2YXFC@29|Myxococcales	28221|Deltaproteobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_5520725_0	1415779.JOMH01000001_gene2583	5.423e-279	866.0	COG0129@1|root,COG0129@2|Bacteria,1MUTQ@1224|Proteobacteria,1RMP2@1236|Gammaproteobacteria,1X4TP@135614|Xanthomonadales	135614|Xanthomonadales	E	Belongs to the IlvD Edd family	-	-	-	-	-	-	-	-	-	-	-	-	ILVD_EDD
HKD3_k127_5520725_12	1163617.SCD_n00028	1.09e-125	407.0	COG0682@1|root,COG0682@2|Bacteria,1MVE3@1224|Proteobacteria,2VHEW@28216|Betaproteobacteria	28216|Betaproteobacteria	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	lgt	-	-	ko:K13292	-	-	-	-	ko00000,ko01000	-	-	-	LGT
HKD3_k127_5520725_46	1387312.BAUS01000004_gene1432	2.168e-11	71.0	COG3030@1|root,COG3030@2|Bacteria,1NHHU@1224|Proteobacteria,2VX8I@28216|Betaproteobacteria,2KN6I@206350|Nitrosomonadales	206350|Nitrosomonadales	S	PFAM FxsA cytoplasmic membrane protein	-	-	-	ko:K07113	-	-	-	-	ko00000	-	-	-	FxsA
HKD3_k127_5520725_42	76114.ebA3572	6.38e-31	124.0	COG1324@1|root,COG1324@2|Bacteria,1N6TN@1224|Proteobacteria,2VUC8@28216|Betaproteobacteria,2KX0I@206389|Rhodocyclales	206389|Rhodocyclales	P	protein involved in tolerance to divalent cations	cutA1	-	-	ko:K03926	-	-	-	-	ko00000	-	-	-	CutA1
HKD3_k127_5520725_40	1163617.SCD_n02789	1.653e-32	136.0	COG4232@1|root,COG4232@2|Bacteria,1MU8W@1224|Proteobacteria,2VI8I@28216|Betaproteobacteria	28216|Betaproteobacteria	CO	Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps	dsbD	-	1.8.1.8	ko:K04084	-	-	-	-	ko00000,ko01000,ko03110	5.A.1.1	-	-	DsbC,DsbD,Thioredoxin_2,Thioredoxin_7
HKD3_k127_5520725_37	1288494.EBAPG3_8790	5.592e-39	151.0	COG0526@1|root,COG0526@2|Bacteria,1MZ5J@1224|Proteobacteria,2VU93@28216|Betaproteobacteria,3732S@32003|Nitrosomonadales	28216|Betaproteobacteria	CO	Thioredoxin-like	tlpA	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,Redoxin
HKD3_k127_5520725_32	395494.Galf_2880	2.806e-53	192.0	COG0511@1|root,COG0511@2|Bacteria,1RCXA@1224|Proteobacteria,2VR5S@28216|Betaproteobacteria,44VSU@713636|Nitrosomonadales	28216|Betaproteobacteria	I	first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA	accB	-	-	ko:K02160	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742	RC00040,RC00367	ko00000,ko00001,ko00002	-	-	-	Biotin_lipoyl
HKD3_k127_5520725_3	1095769.CAHF01000014_gene2868	3.844e-247	769.0	COG0439@1|root,COG0439@2|Bacteria,1MU4H@1224|Proteobacteria,2VISB@28216|Betaproteobacteria,472TI@75682|Oxalobacteraceae	28216|Betaproteobacteria	I	PFAM Carbamoyl-phosphate synthase L chain, ATP binding domain, Biotin carboxylase C-terminal domain, Carbamoyl-phosphate synthase L chain, N-terminal domain	accC	GO:0003674,GO:0003824,GO:0004075,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016053,GO:0016874,GO:0016879,GO:0019216,GO:0019217,GO:0019222,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032787,GO:0042304,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046394,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0072330,GO:0080090,GO:1901576	6.3.4.14,6.4.1.2	ko:K01961	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04385	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
HKD3_k127_5520725_21	292415.Tbd_0180	4.275e-87	317.0	COG2264@1|root,COG2264@2|Bacteria,1MUPC@1224|Proteobacteria,2VH76@28216|Betaproteobacteria,1KRXW@119069|Hydrogenophilales	119069|Hydrogenophilales	J	Ribosomal protein L11 methyltransferase (PrmA)	-	-	-	ko:K02687	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PrmA
HKD3_k127_5520725_34	522306.CAP2UW1_4140	4.424e-43	168.0	COG1273@1|root,COG1273@2|Bacteria,1QVC4@1224|Proteobacteria,2WGPK@28216|Betaproteobacteria	28216|Betaproteobacteria	S	TIGRFAM MJ0042 family finger-like protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF3426,zinc_ribbon_4,zinc_ribbon_5
HKD3_k127_5520725_2	1266925.JHVX01000012_gene1727	1.062e-263	819.0	COG0174@1|root,COG0174@2|Bacteria,1MUGQ@1224|Proteobacteria,2VHYE@28216|Betaproteobacteria,372EA@32003|Nitrosomonadales	28216|Betaproteobacteria	E	TIGRFAM glutamine synthetase, type I	glnA	GO:0003674,GO:0003824,GO:0006725,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016866,GO:0034022,GO:0042537,GO:0044237,GO:0050486,GO:0071704,GO:1901360	5.4.4.3,6.3.1.2	ko:K01915,ko:K20712	ko00220,ko00250,ko00627,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00627,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253,R06988,R09284	RC00010,RC01754,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
HKD3_k127_5520725_45	1123487.KB892857_gene2346	8.975e-13	77.0	2BWQ4@1|root,32QZV@2|Bacteria,1MZQ9@1224|Proteobacteria,2VSNR@28216|Betaproteobacteria,2KWKW@206389|Rhodocyclales	206389|Rhodocyclales	S	Domain of unknown function (DUF4124)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4124
HKD3_k127_5520725_15	62928.azo0736	1.035e-112	376.0	COG3852@1|root,COG3852@2|Bacteria,1MVN6@1224|Proteobacteria,2VJN7@28216|Betaproteobacteria,2KUZZ@206389|Rhodocyclales	206389|Rhodocyclales	T	Signal transduction histidine kinase, nitrogen specific	ntrB	-	2.7.13.3	ko:K07708	ko02020,map02020	M00497	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS,PAS_4
HKD3_k127_5520725_4	640081.Dsui_1051	3.085e-208	658.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VHSB@28216|Betaproteobacteria,2KV3K@206389|Rhodocyclales	206389|Rhodocyclales	T	COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains	ntrC	-	-	ko:K07712	ko02020,map02020	M00497	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD3_k127_5520725_33	1121438.JNJA01000007_gene1640	3.077e-43	173.0	COG0457@1|root,COG0457@2|Bacteria,1RIYN@1224|Proteobacteria,42T31@68525|delta/epsilon subdivisions,2WPYY@28221|Deltaproteobacteria,2M9SE@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	SGNH hydrolase-like domain, acetyltransferase AlgX	-	-	-	-	-	-	-	-	-	-	-	-	ALGX
HKD3_k127_5520725_6	644968.DFW101_2916	1.196e-146	478.0	COG1696@1|root,COG1696@2|Bacteria,1MUXN@1224|Proteobacteria,42MIR@68525|delta/epsilon subdivisions,2WJ85@28221|Deltaproteobacteria,2M8UI@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	PFAM membrane bound O-acyl transferase MBOAT	-	-	-	ko:K19294	-	-	-	-	ko00000	-	-	-	MBOAT
HKD3_k127_5520725_16	1485544.JQKP01000002_gene1538	1.074e-98	329.0	COG0708@1|root,COG0708@2|Bacteria,1MVII@1224|Proteobacteria,2VH7N@28216|Betaproteobacteria,44VA6@713636|Nitrosomonadales	28216|Betaproteobacteria	L	Endonuclease/Exonuclease/phosphatase family	xthA	-	3.1.11.2	ko:K01142	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exo_endo_phos
HKD3_k127_5520725_39	1123392.AQWL01000005_gene3179	1.204e-32	134.0	COG0695@1|root,COG0695@2|Bacteria,1N7X3@1224|Proteobacteria,2VVPB@28216|Betaproteobacteria,1KSYP@119069|Hydrogenophilales	119069|Hydrogenophilales	O	Domain of unknown function (DUF4124)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4124,Glutaredoxin
HKD3_k127_5520725_1	1485544.JQKP01000012_gene2151	2.253e-265	835.0	COG0339@1|root,COG0339@2|Bacteria,1MU1K@1224|Proteobacteria,2VHPQ@28216|Betaproteobacteria,44VER@713636|Nitrosomonadales	28216|Betaproteobacteria	E	PFAM peptidase M3A and M3B thimet oligopeptidase F	prlC	-	3.4.24.70	ko:K01414	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3
HKD3_k127_5520725_25	266264.Rmet_0433	3.99e-71	252.0	COG1208@1|root,COG1208@2|Bacteria,1R9ZD@1224|Proteobacteria,2VJUN@28216|Betaproteobacteria,1JZRV@119060|Burkholderiaceae	28216|Betaproteobacteria	JM	Nucleotidyl transferase	rmlA	-	2.7.7.99	ko:K00992	ko00520,ko01100,map00520,map01100	-	R11025	RC00002	ko00000,ko00001,ko01000	-	-	-	NTP_transferase
HKD3_k127_5520725_11	265072.Mfla_2148	3.291e-131	430.0	COG3178@1|root,COG3178@2|Bacteria,1MXCH@1224|Proteobacteria,2VHBC@28216|Betaproteobacteria,2KM5S@206350|Nitrosomonadales	206350|Nitrosomonadales	S	Phosphotransferase enzyme family	-	-	2.7.1.221	ko:K07102	ko00520,ko01100,map00520,map01100	-	R08968,R11024	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	APH
HKD3_k127_5520725_5	1123392.AQWL01000005_gene3071	2.299e-176	581.0	COG1452@1|root,COG1452@2|Bacteria,1MUJC@1224|Proteobacteria,2VIJ7@28216|Betaproteobacteria,1KRHD@119069|Hydrogenophilales	119069|Hydrogenophilales	M	Organic solvent tolerance protein	-	-	-	ko:K04744	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	OstA_C
HKD3_k127_5520725_8	1163617.SCD_n02560	5.298e-134	443.0	COG0760@1|root,COG0760@2|Bacteria,1MVB3@1224|Proteobacteria,2VHHS@28216|Betaproteobacteria	28216|Betaproteobacteria	M	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation	surA	-	5.2.1.8	ko:K03771	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_3,SurA_N
HKD3_k127_5520725_14	1266925.JHVX01000004_gene1149	2.82e-119	409.0	COG0116@1|root,COG0116@2|Bacteria,1MUQM@1224|Proteobacteria,2VHMY@28216|Betaproteobacteria,372QJ@32003|Nitrosomonadales	28216|Betaproteobacteria	L	THUMP	rlmL	-	-	ko:K07444	-	-	-	-	ko00000,ko01000	-	-	-	THUMP,UPF0020
HKD3_k127_5520725_18	1095769.CAHF01000003_gene1060	7.357e-94	314.0	COG0842@1|root,COG0842@2|Bacteria,1N55T@1224|Proteobacteria,2VJ7R@28216|Betaproteobacteria,476ZK@75682|Oxalobacteraceae	28216|Betaproteobacteria	V	ABC-2 type transporter	nodJ	-	-	ko:K09694	ko02010,map02010	M00252	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.102	-	-	ABC2_membrane
HKD3_k127_5520725_27	78245.Xaut_2571	3.343e-69	246.0	COG0111@1|root,COG0111@2|Bacteria,1MW1U@1224|Proteobacteria,2TSUU@28211|Alphaproteobacteria,3EYCN@335928|Xanthobacteraceae	28211|Alphaproteobacteria	EH	D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain	-	-	1.1.1.79,1.1.1.81	ko:K12972	ko00260,ko00620,ko00630,ko01100,ko01110,ko01120,map00260,map00620,map00630,map01100,map01110,map01120	-	R00465,R01388,R01392,R02527	RC00031,RC00042,RC00670	ko00000,ko00001,ko01000	-	-	-	2-Hacid_dh_C
HKD3_k127_5520725_24	113395.AXAI01000026_gene1838	1.695e-77	272.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2TQWK@28211|Alphaproteobacteria,3K63T@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HKD3_k127_5520725_9	1380394.JADL01000003_gene4756	3.417e-133	432.0	COG2159@1|root,COG2159@2|Bacteria,1N0C7@1224|Proteobacteria,2TRXY@28211|Alphaproteobacteria,2JUHF@204441|Rhodospirillales	204441|Rhodospirillales	S	Amidohydrolase	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
HKD3_k127_5520725_30	1500301.JQMF01000012_gene5375	1.54e-60	212.0	COG0432@1|root,COG0432@2|Bacteria,1RH13@1224|Proteobacteria,2U945@28211|Alphaproteobacteria,4BDY9@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Uncharacterised protein family UPF0047	-	-	-	-	-	-	-	-	-	-	-	-	UPF0047
HKD3_k127_5520725_13	1095769.CAHF01000003_gene1061	1.481e-125	426.0	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,2VI3G@28216|Betaproteobacteria,476I6@75682|Oxalobacteraceae	28216|Betaproteobacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	nodI	-	-	ko:K01990,ko:K09695	ko02010,map02010	M00252,M00254	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.102	-	-	ABC_tran
HKD3_k127_5520725_19	388051.AUFE01000089_gene5591	3.002e-91	314.0	COG3181@1|root,COG3181@2|Bacteria,1R43T@1224|Proteobacteria,2VHTA@28216|Betaproteobacteria	28216|Betaproteobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HKD3_k127_5520725_28	757424.Hsero_4307	2.779e-63	229.0	COG2945@1|root,COG2945@2|Bacteria,1MUDY@1224|Proteobacteria,2VJ8M@28216|Betaproteobacteria,4732H@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Serine aminopeptidase, S33	-	-	-	ko:K07018	-	-	-	-	ko00000	-	-	-	Hydrolase_4,Peptidase_S15
HKD3_k127_5520725_35	1123256.KB907928_gene1969	5.575e-43	161.0	COG3411@1|root,COG3411@2|Bacteria,1MZR4@1224|Proteobacteria,1S8U3@1236|Gammaproteobacteria,1X7ZG@135614|Xanthomonadales	135614|Xanthomonadales	C	Ferredoxin	-	-	-	-	-	-	-	-	-	-	-	-	2Fe-2S_thioredx
HKD3_k127_5520725_29	1122164.JHWF01000017_gene540	5.04e-62	242.0	COG1560@1|root,COG1560@2|Bacteria,1MVNI@1224|Proteobacteria,1RXSU@1236|Gammaproteobacteria,1JDJP@118969|Legionellales	118969|Legionellales	M	lipid A biosynthesis	waaM	-	2.3.1.241	ko:K02517	ko00540,ko01100,map00540,map01100	M00060	R05146	RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Lip_A_acyltrans
HKD3_k127_5520725_49	936572.HMPREF1148_0077	0.0003006	54.0	COG0736@1|root,COG0736@2|Bacteria,1VA0T@1239|Firmicutes,4H55G@909932|Negativicutes	909932|Negativicutes	I	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein	acpS	-	2.7.8.7	ko:K00997	ko00770,map00770	-	R01625	RC00002	ko00000,ko00001,ko01000	-	-	-	ACPS
HKD3_k127_5520725_17	1122165.AUHS01000023_gene238	4.136e-98	349.0	COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,1RMDE@1236|Gammaproteobacteria,1JD6F@118969|Legionellales	118969|Legionellales	IQ	Beta-ketoacyl synthase, C-terminal domain	-	-	2.3.1.41	ko:K00647	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
HKD3_k127_5520725_7	1230343.CANP01000023_gene1489	5.543e-139	455.0	COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,1RMDE@1236|Gammaproteobacteria,1JDCZ@118969|Legionellales	118969|Legionellales	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	-	-	2.3.1.179,2.3.1.41	ko:K00647,ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
HKD3_k127_5520725_43	1230343.CANP01000023_gene1488	3.416e-22	106.0	COG0764@1|root,COG0764@2|Bacteria,1PCKD@1224|Proteobacteria,1SXNH@1236|Gammaproteobacteria,1JDAD@118969|Legionellales	118969|Legionellales	I	FabA-like domain	fabA	-	-	-	-	-	-	-	-	-	-	-	FabA
HKD3_k127_5520725_36	1094715.CM001373_gene2813	9.568e-40	151.0	COG0236@1|root,COG0236@2|Bacteria,1P33T@1224|Proteobacteria,1T1D6@1236|Gammaproteobacteria,1JGNW@118969|Legionellales	118969|Legionellales	IQ	Phosphopantetheine attachment site	-	-	-	-	-	-	-	-	-	-	-	-	PP-binding
HKD3_k127_5520725_31	344747.PM8797T_12848	1.062e-58	224.0	COG1028@1|root,COG1028@2|Bacteria,2IXE0@203682|Planctomycetes	203682|Planctomycetes	IQ	with different specificities (related to short-chain alcohol	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HKD3_k127_5520725_20	272624.lpg0358	9.392e-91	305.0	COG0623@1|root,COG0623@2|Bacteria,1N64Z@1224|Proteobacteria,1T3N8@1236|Gammaproteobacteria,1JC7V@118969|Legionellales	118969|Legionellales	I	KR domain	-	-	1.3.1.104	ko:K10780	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00083	R01404,R04430,R04725,R04956,R04959,R04962,R04967,R04970	RC00052,RC00076,RC00120	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HKD3_k127_5568266_0	1005395.CSV86_20843	2.352e-209	657.0	COG1960@1|root,COG1960@2|Bacteria,1MUK0@1224|Proteobacteria,1RNBX@1236|Gammaproteobacteria,1YWNP@136845|Pseudomonas putida group	1236|Gammaproteobacteria	C	PFAM Acyl-CoA dehydrogenase	gcdH	-	1.3.8.6	ko:K00252	ko00071,ko00310,ko00362,ko00380,ko01100,ko01120,ko01130,map00071,map00310,map00362,map00380,map01100,map01120,map01130	M00032	R02487,R02488,R10074	RC00052,RC00156	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HKD3_k127_5568266_5	1121943.KB899993_gene64	7.306e-76	279.0	COG0625@1|root,COG0625@2|Bacteria,1RA4Y@1224|Proteobacteria,1S2I8@1236|Gammaproteobacteria,1XJ5Z@135619|Oceanospirillales	135619|Oceanospirillales	O	Maleylacetoacetate isomerase	-	-	5.2.1.4	ko:K01801	ko00350,ko01100,ko01120,map00350,map01100,map01120	-	R03868	RC00867	ko00000,ko00001,ko01000	-	-	-	GST_C_2,GST_C_3,GST_N,GST_N_3
HKD3_k127_5568266_4	1123073.KB899241_gene2973	1.03e-76	271.0	COG0179@1|root,COG0179@2|Bacteria,1MVFA@1224|Proteobacteria,1RN6Y@1236|Gammaproteobacteria,1X54M@135614|Xanthomonadales	135614|Xanthomonadales	Q	fumarylacetoacetate hydrolase	-	-	3.7.1.20	ko:K16165	ko00350,ko01100,ko01120,map00350,map01100,map01120	-	R01085	RC00326,RC00446	ko00000,ko00001,ko01000	-	-	-	FAA_hydrolase
HKD3_k127_5568266_6	1122221.JHVI01000003_gene370	4.198e-67	250.0	COG0657@1|root,COG0657@2|Bacteria,1WMGU@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	I	alpha/beta hydrolase fold	-	-	3.5.1.9	ko:K01432	ko00380,ko00630,ko01100,map00380,map00630,map01100	M00038	R00988,R01959,R04911	RC00263,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	Abhydrolase_3
HKD3_k127_5568266_11	1123401.JHYQ01000022_gene1110	2.984e-37	149.0	COG1309@1|root,COG1309@2|Bacteria,1NBKX@1224|Proteobacteria,1S7KQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
HKD3_k127_5568266_2	323848.Nmul_A0010	6.714e-153	505.0	COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,1MU8P@1224|Proteobacteria,2VH6S@28216|Betaproteobacteria,371M0@32003|Nitrosomonadales	28216|Betaproteobacteria	H	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate	ribB	-	3.5.4.25,4.1.99.12	ko:K14652	ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110	M00125,M00840	R00425,R07281	RC00293,RC01792,RC01815,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	-	DHBP_synthase,GTP_cyclohydro2
HKD3_k127_5568266_8	159450.NH14_03210	2.285e-46	175.0	COG0054@1|root,COG0054@2|Bacteria,1RD9J@1224|Proteobacteria,2VQGE@28216|Betaproteobacteria,1K1B3@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin	ribH	-	2.5.1.78	ko:K00794	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R04457	RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	DMRL_synthase
HKD3_k127_5568266_9	640081.Dsui_0713	2.981e-44	168.0	COG0781@1|root,COG0781@2|Bacteria,1RHFZ@1224|Proteobacteria,2VSI6@28216|Betaproteobacteria,2KWPK@206389|Rhodocyclales	206389|Rhodocyclales	K	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons	nusB	-	-	ko:K03625	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	NusB
HKD3_k127_5568266_3	1123504.JQKD01000008_gene5386	7.689e-102	343.0	COG0611@1|root,COG0611@2|Bacteria,1MU9X@1224|Proteobacteria,2VI0Q@28216|Betaproteobacteria,4AABK@80864|Comamonadaceae	28216|Betaproteobacteria	H	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1	thiL	-	2.7.4.16	ko:K00946	ko00730,ko01100,map00730,map01100	M00127	R00617	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
HKD3_k127_5568266_10	748247.AZKH_4320	1.333e-42	167.0	COG1267@1|root,COG1267@2|Bacteria,1MZJA@1224|Proteobacteria,2VSP2@28216|Betaproteobacteria,2KW78@206389|Rhodocyclales	206389|Rhodocyclales	I	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)	pgpA	-	3.1.3.27	ko:K01095	ko00564,ko01100,map00564,map01100	-	R02029	RC00017	ko00000,ko00001,ko01000	-	-	-	PgpA
HKD3_k127_5568266_12	717605.Theco_0907	5.886e-36	156.0	COG0454@1|root,COG0456@2|Bacteria,1V37I@1239|Firmicutes,4HGJH@91061|Bacilli,26TQ6@186822|Paenibacillaceae	91061|Bacilli	K	FR47-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HKD3_k127_5568266_7	76114.ebA3399	1.547e-46	173.0	COG1546@1|root,COG1546@2|Bacteria,1RH2Y@1224|Proteobacteria,2VSQF@28216|Betaproteobacteria,2KWIK@206389|Rhodocyclales	206389|Rhodocyclales	S	Belongs to the CinA family	-	-	3.5.1.42	ko:K03743	ko00760,map00760	-	R02322	RC00100	ko00000,ko00001,ko01000	-	-	-	CinA
HKD3_k127_5568266_1	1304883.KI912532_gene880	3.229e-178	567.0	COG0468@1|root,COG0468@2|Bacteria,1MU3C@1224|Proteobacteria,2VHNA@28216|Betaproteobacteria,2KUUY@206389|Rhodocyclales	206389|Rhodocyclales	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage	recA	-	-	ko:K03553	ko03440,map03440	M00729	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	RecA
HKD3_k127_5646302_0	1217718.ALOU01000027_gene3690	5.29e-238	742.0	COG1048@1|root,COG1048@2|Bacteria,1MU9T@1224|Proteobacteria,2VKDZ@28216|Betaproteobacteria,1K16W@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate	acnA	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
HKD3_k127_5646302_1	1523503.JPMY01000002_gene3992	1.258e-14	78.0	COG0697@1|root,COG0697@2|Bacteria,1MXVF@1224|Proteobacteria	1224|Proteobacteria	EG	COG0697 Permeases of the drug metabolite transporter (DMT) superfamily	-	-	-	ko:K15270	-	-	-	-	ko00000,ko02000	2.A.7.3.7	-	-	EamA
HKD3_k127_5712720_1	1380391.JIAS01000012_gene4231	9.221e-151	480.0	COG0559@1|root,COG0559@2|Bacteria,1MY1E@1224|Proteobacteria,2U0TW@28211|Alphaproteobacteria,2JR66@204441|Rhodospirillales	204441|Rhodospirillales	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_2
HKD3_k127_5712720_0	1380391.JIAS01000012_gene4232	4.626e-154	507.0	COG4177@1|root,COG4177@2|Bacteria,1MUPI@1224|Proteobacteria,2VF1H@28211|Alphaproteobacteria,2JQWD@204441|Rhodospirillales	204441|Rhodospirillales	E	Branched-chain amino acid transport system / permease component	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HKD3_k127_5712720_5	1380391.JIAS01000012_gene4233	9.2e-103	356.0	COG0411@1|root,COG0411@2|Bacteria,1MX51@1224|Proteobacteria,2TTG6@28211|Alphaproteobacteria,2JZ9N@204441|Rhodospirillales	204441|Rhodospirillales	E	Branched-chain amino acid ATP-binding cassette transporter	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
HKD3_k127_5712720_3	883080.HMPREF9697_01486	1.234e-112	369.0	COG0410@1|root,COG0410@2|Bacteria,1MVYI@1224|Proteobacteria,2TSRT@28211|Alphaproteobacteria,3JR1U@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	ABC transporter	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
HKD3_k127_5712720_2	76114.ebA3956	2.76e-148	479.0	COG1092@1|root,COG1092@2|Bacteria,1MUGB@1224|Proteobacteria,2VKNG@28216|Betaproteobacteria,2KUS1@206389|Rhodocyclales	206389|Rhodocyclales	J	Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase	-	-	2.1.1.191	ko:K06969	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_SAM
HKD3_k127_5712720_4	1123393.KB891330_gene898	3.86e-106	357.0	COG1814@1|root,COG1814@2|Bacteria,1MUZE@1224|Proteobacteria,2VJ27@28216|Betaproteobacteria,1KSVB@119069|Hydrogenophilales	119069|Hydrogenophilales	S	VIT family	-	-	-	-	-	-	-	-	-	-	-	-	VIT1
HKD3_k127_5712720_6	926550.CLDAP_06320	1.376e-89	298.0	COG0667@1|root,COG0667@2|Bacteria,2G5YU@200795|Chloroflexi	200795|Chloroflexi	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
HKD3_k127_5725343_4	568706.BN118_3565	6.433e-45	179.0	COG0141@1|root,COG0141@2|Bacteria,1MUUF@1224|Proteobacteria,2VJ7K@28216|Betaproteobacteria,3T2YB@506|Alcaligenaceae	28216|Betaproteobacteria	E	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine	hisD	GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0030145,GO:0034641,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0046914,GO:0052803,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.1.1.23	ko:K00013	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01158,R01163,R03012	RC00099,RC00242,RC00463	ko00000,ko00001,ko00002,ko01000	-	-	-	Histidinol_dh
HKD3_k127_5725343_2	522306.CAP2UW1_4032	2.173e-96	319.0	COG0040@1|root,COG0040@2|Bacteria,1MUCY@1224|Proteobacteria,2VIF9@28216|Betaproteobacteria,1KPT2@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	F	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity	hisG	-	2.4.2.17	ko:K00765	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002,ko01000	-	-	-	HisG
HKD3_k127_5725343_3	1123377.AUIV01000016_gene372	2.679e-78	272.0	COG0780@1|root,COG2904@1|root,COG0780@2|Bacteria,COG2904@2|Bacteria,1MW0M@1224|Proteobacteria,1RNXM@1236|Gammaproteobacteria,1X3ZK@135614|Xanthomonadales	135614|Xanthomonadales	S	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)	queF	-	1.7.1.13	ko:K06879	ko00790,ko01100,map00790,map01100	-	R07605	RC01875	ko00000,ko00001,ko01000,ko03016	-	-	-	QueF,QueF_N
HKD3_k127_5725343_0	323848.Nmul_A0886	5.75e-179	573.0	COG0766@1|root,COG0766@2|Bacteria,1MUH7@1224|Proteobacteria,2VHZN@28216|Betaproteobacteria,371PY@32003|Nitrosomonadales	28216|Betaproteobacteria	M	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine	murA	-	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase
HKD3_k127_5725343_5	1000565.METUNv1_02425	2.524e-26	121.0	COG5007@1|root,COG5007@2|Bacteria,1MZCZ@1224|Proteobacteria,2VU0K@28216|Betaproteobacteria,2KWVP@206389|Rhodocyclales	206389|Rhodocyclales	K	Belongs to the BolA IbaG family	-	-	-	-	-	-	-	-	-	-	-	-	BolA
HKD3_k127_5725343_1	640081.Dsui_1405	8.234e-107	351.0	COG0842@1|root,COG0842@2|Bacteria,1MUH1@1224|Proteobacteria,2VH42@28216|Betaproteobacteria,2KUGF@206389|Rhodocyclales	206389|Rhodocyclales	V	Transport permease protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
HKD3_k127_5902411_1	398527.Bphyt_3972	0.0	1066.0	COG2609@1|root,COG2609@2|Bacteria,1MV21@1224|Proteobacteria,2VHP1@28216|Betaproteobacteria,1K4GC@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	aceE1	GO:0000287,GO:0003674,GO:0003824,GO:0004738,GO:0005488,GO:0005515,GO:0008150,GO:0008152,GO:0016491,GO:0016903,GO:0019842,GO:0030976,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043169,GO:0046872,GO:0046983,GO:0048037,GO:0050662,GO:0055114,GO:0097159,GO:1901363,GO:1901681	1.2.4.1	ko:K00163	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_C,Transketolase_N
HKD3_k127_5902411_2	1002340.AFCF01000033_gene3892	1.118e-131	430.0	COG0745@1|root,COG2114@1|root,COG0745@2|Bacteria,COG2114@2|Bacteria,1MV1V@1224|Proteobacteria,2TXS1@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc
HKD3_k127_5902411_4	1002340.AFCF01000033_gene3891	2.545e-16	83.0	COG2198@1|root,COG2198@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	-	ko:K20976	ko02020,ko02025,map02020,map02025	M00820	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Hpt
HKD3_k127_5902411_0	981384.AEYW01000001_gene1562	0.0	1185.0	COG0642@1|root,COG0642@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2TX3Q@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Histidine kinase-like ATPases	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HAMP,HATPase_c,HisKA,Hpt,Response_reg,dCache_1
HKD3_k127_5902411_3	266264.Rmet_4203	2.966e-111	366.0	COG3181@1|root,COG3181@2|Bacteria,1R4FY@1224|Proteobacteria,2VMZH@28216|Betaproteobacteria	28216|Betaproteobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HKD3_k127_595421_1	522306.CAP2UW1_1149	4.547e-13	74.0	COG2518@1|root,COG2518@2|Bacteria,1RD6S@1224|Proteobacteria,2VJX3@28216|Betaproteobacteria,1KQQ4@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	J	Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)	pcm	-	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
HKD3_k127_595421_0	1349767.GJA_859	0.0	1201.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHFI@28216|Betaproteobacteria,475Z8@75682|Oxalobacteraceae	28216|Betaproteobacteria	V	AcrB/AcrD/AcrF family	mdtC3	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
HKD3_k127_600623_6	1123504.JQKD01000008_gene5351	4.135e-19	93.0	2E4IS@1|root,32ZDU@2|Bacteria,1N7N3@1224|Proteobacteria,2VVSI@28216|Betaproteobacteria,4AFGE@80864|Comamonadaceae	28216|Betaproteobacteria	S	PFAM PsiF repeat protein	psiF	-	-	-	-	-	-	-	-	-	-	-	PsiF_repeat
HKD3_k127_600623_1	1123368.AUIS01000001_gene1868	2.97e-189	602.0	COG2876@1|root,COG2876@2|Bacteria,1QVAD@1224|Proteobacteria,1S11K@1236|Gammaproteobacteria,2NBQA@225057|Acidithiobacillales	225057|Acidithiobacillales	E	DAHP synthetase I family	-	-	2.5.1.54	ko:K03856	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_1
HKD3_k127_600623_5	1288494.EBAPG3_18250	1.748e-60	230.0	COG3025@1|root,COG5607@1|root,COG3025@2|Bacteria,COG5607@2|Bacteria,1MY43@1224|Proteobacteria,2VM3G@28216|Betaproteobacteria,372SC@32003|Nitrosomonadales	28216|Betaproteobacteria	S	CHAD	-	-	-	-	-	-	-	-	-	-	-	-	CHAD,CYTH
HKD3_k127_600623_2	1121035.AUCH01000003_gene1343	1.673e-171	551.0	COG2326@1|root,COG2326@2|Bacteria,1MVE2@1224|Proteobacteria,2VGZV@28216|Betaproteobacteria,2KU63@206389|Rhodocyclales	206389|Rhodocyclales	S	Polyphosphate kinase 2 (PPK2)	-	-	-	-	-	-	-	-	-	-	-	-	PPK2
HKD3_k127_600623_4	1304883.KI912532_gene3248	1.605e-111	392.0	COG0429@1|root,COG0429@2|Bacteria,1MWV1@1224|Proteobacteria,2VHZ1@28216|Betaproteobacteria,2KVC0@206389|Rhodocyclales	206389|Rhodocyclales	S	alpha/beta hydrolase fold	-	-	-	ko:K07019	-	-	-	-	ko00000	-	-	-	Abhydrolase_1
HKD3_k127_600623_0	580332.Slit_2101	6.423e-202	638.0	COG1109@1|root,COG1109@2|Bacteria,1MUA5@1224|Proteobacteria,2VJ29@28216|Betaproteobacteria,44VB5@713636|Nitrosomonadales	28216|Betaproteobacteria	G	phosphoglucomutase phosphomannomutase alpha beta alpha domain I	algC	GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0004614,GO:0004615,GO:0005488,GO:0005975,GO:0005976,GO:0006082,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009243,GO:0009244,GO:0009311,GO:0009312,GO:0009405,GO:0009987,GO:0016051,GO:0016053,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0019752,GO:0033692,GO:0034637,GO:0034645,GO:0042120,GO:0042121,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044281,GO:0044283,GO:0044419,GO:0046394,GO:0046401,GO:0046402,GO:0046872,GO:0051704,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	5.4.2.2,5.4.2.8	ko:K01835,ko:K01840,ko:K15778	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114,M00549	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
HKD3_k127_600623_3	497964.CfE428DRAFT_5715	3.955e-120	398.0	COG1171@1|root,COG1171@2|Bacteria,46S65@74201|Verrucomicrobia	74201|Verrucomicrobia	E	Pyridoxal-phosphate dependent enzyme	-	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP,Thr_dehydrat_C
HKD3_k127_6046992_0	1454004.AW11_02623	6.114e-121	396.0	COG1741@1|root,COG1741@2|Bacteria,1MWIP@1224|Proteobacteria,2VHGK@28216|Betaproteobacteria,1KQYT@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	S	Pirin C-terminal cupin domain	-	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin,Pirin_C
HKD3_k127_6046992_1	1265502.KB905945_gene652	1.798e-59	211.0	COG1403@1|root,COG1403@2|Bacteria,1MWEQ@1224|Proteobacteria,2VKQH@28216|Betaproteobacteria,4AB9G@80864|Comamonadaceae	28216|Betaproteobacteria	L	PFAM HNH endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	HNH_5
HKD3_k127_6109831_2	1123354.AUDR01000018_gene1174	2.714e-140	467.0	COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,2VIEJ@28216|Betaproteobacteria,1KRED@119069|Hydrogenophilales	119069|Hydrogenophilales	J	Zinc finger found in FPG and IleRS	-	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1,zf-FPG_IleRS
HKD3_k127_6109831_6	1163617.SCD_n02132	4.721e-98	330.0	COG0196@1|root,COG0196@2|Bacteria,1MV9I@1224|Proteobacteria,2VHIP@28216|Betaproteobacteria	28216|Betaproteobacteria	H	Belongs to the ribF family	ribF	-	2.7.1.26,2.7.7.2	ko:K11753	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00161,R00549	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_syn,Flavokinase
HKD3_k127_6109831_1	1123261.AXDW01000006_gene2409	1.93e-223	736.0	COG1074@1|root,COG1074@2|Bacteria,1MUTF@1224|Proteobacteria,1RPC6@1236|Gammaproteobacteria,1X3M3@135614|Xanthomonadales	135614|Xanthomonadales	L	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA	recB	-	3.1.11.5	ko:K03582	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
HKD3_k127_6109831_3	472759.Nhal_2968	1.324e-119	418.0	COG3857@1|root,COG3857@2|Bacteria,1QUQD@1224|Proteobacteria,1T20Z@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	PD-(D/E)XK nuclease superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_1
HKD3_k127_6109831_9	1379270.AUXF01000002_gene1141	1.844e-18	87.0	COG5470@1|root,COG5470@2|Bacteria,1ZU5S@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Domain of unknown function (DUF1330)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1330
HKD3_k127_6109831_10	582515.KR51_00006850	2.714e-08	61.0	COG0484@1|root,COG0484@2|Bacteria,1G2FB@1117|Cyanobacteria	1117|Cyanobacteria	O	DnaJ-class molecular chaperone with C-terminal Zn finger domain	-	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ
HKD3_k127_6109831_5	1183438.GKIL_2349	7.966e-100	336.0	COG0656@1|root,COG0656@2|Bacteria,1G4UQ@1117|Cyanobacteria	1117|Cyanobacteria	S	aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
HKD3_k127_6109831_0	522306.CAP2UW1_0596	4.565e-279	883.0	COG0243@1|root,COG0243@2|Bacteria,1NR6J@1224|Proteobacteria,2VHHZ@28216|Betaproteobacteria,1KQ92@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	C	Molybdopterin oxidoreductase Fe4S4 domain	-	-	-	-	-	-	-	-	-	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
HKD3_k127_6109831_8	999541.bgla_1g24320	1.663e-50	184.0	COG3195@1|root,COG3195@2|Bacteria,1RH9S@1224|Proteobacteria,2VRV7@28216|Betaproteobacteria,1K3PK@119060|Burkholderiaceae	28216|Betaproteobacteria	S	OHCU decarboxylase	uraD	-	4.1.1.97	ko:K13485	ko00230,ko01100,map00230,map01100	M00546	R06604	RC01551	ko00000,ko00001,ko00002,ko01000	-	-	-	OHCU_decarbox
HKD3_k127_6109831_7	1163617.SCD_n01092	4.904e-75	260.0	COG1974@1|root,COG1974@2|Bacteria,1MW80@1224|Proteobacteria,2VS2C@28216|Betaproteobacteria	28216|Betaproteobacteria	KT	Belongs to the peptidase S24 family	-	-	3.4.21.88	ko:K01356	-	M00729	-	-	ko00000,ko00002,ko01000,ko01002,ko03400	-	-	-	Peptidase_S24
HKD3_k127_6109831_4	1123368.AUIS01000019_gene1225	1.356e-118	397.0	COG0847@1|root,COG0847@2|Bacteria,1MV8Z@1224|Proteobacteria,1T3CM@1236|Gammaproteobacteria,2NDP9@225057|Acidithiobacillales	225057|Acidithiobacillales	L	GIY-YIG type nucleases (URI domain)	-	-	2.7.7.7	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	RNase_T
HKD3_k127_6119557_0	1538295.JY96_07450	1.537e-164	529.0	COG0280@1|root,COG2030@1|root,COG0280@2|Bacteria,COG2030@2|Bacteria,1MWPK@1224|Proteobacteria,2WGKC@28216|Betaproteobacteria,1KJ9Z@119065|unclassified Burkholderiales	28216|Betaproteobacteria	CI	Bifunctional enoyl-CoA hydratase phosphate acetyltransferase	pta	-	2.3.1.19,2.3.1.8	ko:K00625,ko:K00634	ko00430,ko00620,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00650,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00230,R00921,R01174	RC00004,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000	-	-	-	MaoC_dehydratas,PTA_PTB
HKD3_k127_6119557_1	264198.Reut_A1203	3.515e-85	303.0	COG0282@1|root,COG0282@2|Bacteria,1MW61@1224|Proteobacteria,2VHRC@28216|Betaproteobacteria,1K1WI@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction	ackA	-	2.7.2.1	ko:K00925	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00315,R01353	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetate_kinase
HKD3_k127_6129502_8	1159870.KB907784_gene2064	7.073e-104	353.0	COG0126@1|root,COG0126@2|Bacteria,1MUNU@1224|Proteobacteria,2VHJK@28216|Betaproteobacteria,3T2U5@506|Alcaligenaceae	28216|Betaproteobacteria	F	Belongs to the phosphoglycerate kinase family	pgk	-	2.7.2.3	ko:K00927	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01512	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
HKD3_k127_6129502_26	1396141.BATP01000023_gene638	9.057e-30	136.0	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	yokL	-	-	ko:K03825	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_1,Acetyltransf_4,Acetyltransf_7
HKD3_k127_6129502_2	983917.RGE_44760	1.547e-195	612.0	COG0057@1|root,COG0057@2|Bacteria,1MU93@1224|Proteobacteria,2VHHG@28216|Betaproteobacteria,1KKA5@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family	gapA	GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0036094,GO:0043891,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0097159,GO:1901265,GO:1901363	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Gp_dh_C,Gp_dh_N
HKD3_k127_6129502_17	204773.HEAR0849	8.436e-49	188.0	COG0454@1|root,COG0456@2|Bacteria,1N6RY@1224|Proteobacteria,2WENS@28216|Betaproteobacteria,4749G@75682|Oxalobacteraceae	28216|Betaproteobacteria	K	FR47-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HKD3_k127_6129502_0	76114.ebA1101	2.367e-294	923.0	COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,2VHNX@28216|Betaproteobacteria,2KV91@206389|Rhodocyclales	206389|Rhodocyclales	H	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate	tkt	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
HKD3_k127_6129502_27	305700.B447_02301	9.195e-25	111.0	COG1586@1|root,COG1586@2|Bacteria,1QWFT@1224|Proteobacteria,2VTEG@28216|Betaproteobacteria,2KX46@206389|Rhodocyclales	206389|Rhodocyclales	E	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine	-	-	2.5.1.16	ko:K00797	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	M00034,M00133	R01920,R02869,R08359	RC00021,RC00053	ko00000,ko00001,ko00002,ko01000	-	-	-	AdoMet_dc
HKD3_k127_6129502_9	76114.ebA2152	2.113e-96	326.0	COG0421@1|root,COG1586@1|root,COG0421@2|Bacteria,COG1586@2|Bacteria,1MVV5@1224|Proteobacteria,2WGFP@28216|Betaproteobacteria,2KUTH@206389|Rhodocyclales	206389|Rhodocyclales	E	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	speE	-	2.5.1.16	ko:K00797	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	M00034,M00133	R01920,R02869,R08359	RC00021,RC00053	ko00000,ko00001,ko00002,ko01000	-	-	-	Spermine_synth
HKD3_k127_6129502_21	522306.CAP2UW1_3206	3.896e-42	174.0	COG3485@1|root,COG3485@2|Bacteria,1MUYX@1224|Proteobacteria,2VQFX@28216|Betaproteobacteria	28216|Betaproteobacteria	Q	intradiol ring-cleavage dioxygenase	-	-	1.13.11.3	ko:K00449	ko00362,ko00624,ko01100,ko01120,ko01220,map00362,map00624,map01100,map01120,map01220	-	R01631,R03549	RC00388,RC00953	br01602,ko00000,ko00001,ko01000	-	-	-	Dioxygenase_C
HKD3_k127_6129502_25	497321.C664_09948	4.178e-31	136.0	COG0640@1|root,COG0640@2|Bacteria,1Q9DY@1224|Proteobacteria,2VVWF@28216|Betaproteobacteria,2KXM8@206389|Rhodocyclales	206389|Rhodocyclales	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_5
HKD3_k127_6129502_16	497321.C664_09933	1.944e-52	201.0	COG5501@1|root,COG5501@2|Bacteria,1RH4J@1224|Proteobacteria,2VT8I@28216|Betaproteobacteria,2KWNG@206389|Rhodocyclales	206389|Rhodocyclales	S	Sulfur oxidation protein SoxY	soxY	-	-	ko:K17226	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	-	-	-	SoxY
HKD3_k127_6129502_20	93220.LV28_13550	2.808e-44	163.0	COG5501@1|root,COG5501@2|Bacteria,1N097@1224|Proteobacteria,2VU95@28216|Betaproteobacteria,1K8XJ@119060|Burkholderiaceae	28216|Betaproteobacteria	S	oxidation protein	soxZ	-	-	ko:K17227	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	-	-	-	SoxZ
HKD3_k127_6129502_24	375286.mma_0444	3.39e-38	152.0	COG1416@1|root,COG1416@2|Bacteria,1RKXJ@1224|Proteobacteria,2VTZ3@28216|Betaproteobacteria,474RQ@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	DsrE/DsrF-like family	-	-	-	ko:K09004	-	-	-	-	ko00000	-	-	-	DrsE
HKD3_k127_6129502_5	395495.Lcho_3780	4.649e-120	393.0	COG3258@1|root,COG3258@2|Bacteria,1MXB0@1224|Proteobacteria,2VJ8Q@28216|Betaproteobacteria,1KJFD@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Thiosulfate-oxidizing multienzyme system protein SoxA	-	-	-	ko:K17222	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	-	-	-	-
HKD3_k127_6129502_11	864051.BurJ1DRAFT_3451	6.764e-86	291.0	COG2010@1|root,COG2010@2|Bacteria,1P1GY@1224|Proteobacteria,2VP4W@28216|Betaproteobacteria,1KMCY@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Cytochrome c	soxX	-	-	ko:K17223	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	-	-	-	Cytochrom_C
HKD3_k127_6129502_22	1286093.C266_19545	1.205e-41	160.0	COG0526@1|root,COG0526@2|Bacteria,1MYNI@1224|Proteobacteria,2VTDT@28216|Betaproteobacteria,1KHMT@119060|Burkholderiaceae	28216|Betaproteobacteria	CO	Thioredoxin-like	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,Redoxin
HKD3_k127_6129502_1	1217718.ALOU01000009_gene1093	9.982e-285	887.0	COG0737@1|root,COG0737@2|Bacteria,1MX03@1224|Proteobacteria,2VJTS@28216|Betaproteobacteria,1K2Y9@119060|Burkholderiaceae	28216|Betaproteobacteria	F	Belongs to the 5'-nucleotidase family	soxB	-	3.1.3.5,3.6.1.45	ko:K11751,ko:K17224	ko00230,ko00240,ko00760,ko00920,ko01100,ko01110,ko01120,map00230,map00240,map00760,map00920,map01100,map01110,map01120	M00595	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346,R10151	RC00017,RC03151,RC03152	ko00000,ko00001,ko00002,ko01000	-	-	-	5_nucleotid_C
HKD3_k127_6129502_10	1163617.SCD_n01008	1.008e-95	329.0	COG2358@1|root,COG2358@2|Bacteria,1PNJV@1224|Proteobacteria,2VI8H@28216|Betaproteobacteria	28216|Betaproteobacteria	S	TRAP transporter solute receptor TAXI family	-	-	-	-	-	-	-	-	-	-	-	-	NMT1_3
HKD3_k127_6129502_3	1003200.AXXA_13884	5.593e-181	578.0	COG0162@1|root,COG0162@2|Bacteria,1MVUQ@1224|Proteobacteria,2VHF7@28216|Betaproteobacteria,3T2GD@506|Alcaligenaceae	28216|Betaproteobacteria	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	-	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	S4,S4_2,tRNA-synt_1b
HKD3_k127_6129502_19	395495.Lcho_4356	8.905e-47	185.0	COG0625@1|root,COG0625@2|Bacteria,1RAIN@1224|Proteobacteria,2VKU4@28216|Betaproteobacteria	28216|Betaproteobacteria	O	Belongs to the GST superfamily	-	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C,GST_C_3,GST_N
HKD3_k127_6129502_7	1288494.EBAPG3_2910	5.698e-112	377.0	COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,2VHBS@28216|Betaproteobacteria,3726D@32003|Nitrosomonadales	28216|Betaproteobacteria	M	PFAM peptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
HKD3_k127_6129502_6	795666.MW7_2314	3.326e-113	383.0	COG2377@1|root,COG2377@2|Bacteria,1MV4E@1224|Proteobacteria,2VHCE@28216|Betaproteobacteria,1JZNR@119060|Burkholderiaceae	28216|Betaproteobacteria	F	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling	anmK	-	2.7.1.170	ko:K09001	-	-	-	-	ko00000,ko01000	-	-	-	AnmK
HKD3_k127_6129502_15	1207063.P24_00340	4.394e-54	194.0	COG0599@1|root,COG0599@2|Bacteria,1RDSG@1224|Proteobacteria,2U72V@28211|Alphaproteobacteria,2JZJM@204441|Rhodospirillales	204441|Rhodospirillales	S	Carboxymuconolactone decarboxylase family	-	-	-	-	-	-	-	-	-	-	-	-	CMD
HKD3_k127_6129502_14	1000565.METUNv1_02878	1.814e-60	211.0	COG0316@1|root,COG0316@2|Bacteria,1RHCW@1224|Proteobacteria,2VR2M@28216|Betaproteobacteria,2KWB8@206389|Rhodocyclales	206389|Rhodocyclales	C	Required for insertion of 4Fe-4S clusters	erpA	-	-	ko:K15724	-	-	-	-	ko00000	-	-	-	Fe-S_biosyn
HKD3_k127_6129502_23	1000565.METUNv1_02879	7.689e-41	154.0	COG1664@1|root,COG1664@2|Bacteria,1MZN0@1224|Proteobacteria,2VTZQ@28216|Betaproteobacteria,2KWWR@206389|Rhodocyclales	206389|Rhodocyclales	M	Integral membrane protein CcmA involved in cell shape determination	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
HKD3_k127_6129502_28	640081.Dsui_1332	9.975e-25	120.0	28IJP@1|root,2Z8KI@2|Bacteria,1R9DP@1224|Proteobacteria,2VVJ7@28216|Betaproteobacteria,2KX2H@206389|Rhodocyclales	206389|Rhodocyclales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_6129502_4	243365.CV_3695	4.073e-153	492.0	COG0002@1|root,COG0002@2|Bacteria,1MVJ6@1224|Proteobacteria,2VJD7@28216|Betaproteobacteria,2KQFE@206351|Neisseriales	206351|Neisseriales	E	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde	argC	-	1.2.1.38	ko:K00145	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R03443	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
HKD3_k127_6129502_13	1000565.METUNv1_02882	1.717e-61	222.0	COG0103@1|root,COG0103@2|Bacteria,1RD4A@1224|Proteobacteria,2VR5R@28216|Betaproteobacteria,2KWFU@206389|Rhodocyclales	206389|Rhodocyclales	J	Belongs to the universal ribosomal protein uS9 family	rpsI	-	-	ko:K02996	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S9
HKD3_k127_6129502_12	640081.Dsui_1330	4.909e-71	242.0	COG0102@1|root,COG0102@2|Bacteria,1RA11@1224|Proteobacteria,2VQ07@28216|Betaproteobacteria,2KW9N@206389|Rhodocyclales	206389|Rhodocyclales	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly	rplM	-	-	ko:K02871	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13
HKD3_k127_6129502_18	305700.B447_07322	1.462e-48	178.0	COG1765@1|root,COG1765@2|Bacteria,1RCZW@1224|Proteobacteria,2VR62@28216|Betaproteobacteria,2KWBK@206389|Rhodocyclales	206389|Rhodocyclales	O	redox protein, regulator of disulfide bond formation	-	-	-	ko:K07397	-	-	-	-	ko00000	-	-	-	OsmC
HKD3_k127_6150145_2	1095769.CAHF01000022_gene55	4.131e-117	380.0	COG1638@1|root,COG1638@2|Bacteria,1MWAW@1224|Proteobacteria,2VJB5@28216|Betaproteobacteria,472A1@75682|Oxalobacteraceae	28216|Betaproteobacteria	G	TRAP-type C4-dicarboxylate transport system, periplasmic component	-	-	-	-	-	-	-	-	-	-	-	-	DctP
HKD3_k127_6150145_7	748247.AZKH_1592	1.153e-61	220.0	COG3090@1|root,COG3090@2|Bacteria,1PJMZ@1224|Proteobacteria,2WA3Y@28216|Betaproteobacteria,2KYXE@206389|Rhodocyclales	2|Bacteria	G	Tripartite ATP-independent periplasmic transporters, DctQ component	MA20_30165	-	-	ko:K11689,ko:K21394	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.56.1	-	-	DctQ
HKD3_k127_6150145_0	1095769.CAHF01000022_gene57	1.11e-213	681.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2VJME@28216|Betaproteobacteria,473G9@75682|Oxalobacteraceae	28216|Betaproteobacteria	G	Tripartite ATP-independent periplasmic transporter, DctM component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
HKD3_k127_6150145_1	1150469.RSPPHO_01089	5.405e-179	573.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2TR2W@28211|Alphaproteobacteria,2JQI2@204441|Rhodospirillales	204441|Rhodospirillales	IQ	COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II	-	-	-	ko:K18661	ko00280,map00280	-	R03383	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C
HKD3_k127_6150145_3	1502852.FG94_03680	3.179e-97	325.0	COG0730@1|root,COG0730@2|Bacteria,1R3V4@1224|Proteobacteria,2VKXN@28216|Betaproteobacteria,474AF@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Sulfite exporter TauE/SafE	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
HKD3_k127_6150145_6	228410.NE1889	4.539e-69	238.0	COG2947@1|root,COG2947@2|Bacteria,1RHRU@1224|Proteobacteria,2VRIB@28216|Betaproteobacteria,3732K@32003|Nitrosomonadales	28216|Betaproteobacteria	S	EVE domain	-	-	-	-	-	-	-	-	-	-	-	-	EVE
HKD3_k127_6150145_8	580332.Slit_2683	1.069e-19	97.0	COG3027@1|root,COG3027@2|Bacteria,1N6YN@1224|Proteobacteria,2VUY2@28216|Betaproteobacteria,44VZ2@713636|Nitrosomonadales	28216|Betaproteobacteria	D	Cell division protein ZapA	zapA	-	-	ko:K09888	-	-	-	-	ko00000,ko03036	-	-	-	ZapA
HKD3_k127_6150145_9	1288494.EBAPG3_10920	4.15e-06	51.0	2EG8X@1|root,33A0Q@2|Bacteria,1NMVN@1224|Proteobacteria,2VY0V@28216|Betaproteobacteria,373M2@32003|Nitrosomonadales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_6150145_5	1288494.EBAPG3_22350	4.427e-73	250.0	COG0782@1|root,COG0782@2|Bacteria,1RAP0@1224|Proteobacteria,2VQ09@28216|Betaproteobacteria,372GF@32003|Nitrosomonadales	28216|Betaproteobacteria	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreB releases sequences of up to 9 nucleotides in length	greB	-	-	ko:K04760	-	-	-	-	ko00000,ko03021	-	-	-	GreA_GreB,GreA_GreB_N
HKD3_k127_6150145_4	1380387.JADM01000001_gene345	3.434e-95	325.0	COG0609@1|root,COG0609@2|Bacteria,1MV9W@1224|Proteobacteria,1RMDF@1236|Gammaproteobacteria,1XIU2@135619|Oceanospirillales	135619|Oceanospirillales	P	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily	-	-	-	ko:K02015	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	FecCD
HKD3_k127_6170652_5	1502770.JQMG01000001_gene2057	1.453e-07	53.0	2DT3B@1|root,33IHT@2|Bacteria,1NK4F@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_6170652_1	1266925.JHVX01000010_gene1332	2.876e-70	248.0	COG1028@1|root,COG1028@2|Bacteria,1MWBC@1224|Proteobacteria,2VMWZ@28216|Betaproteobacteria,372M9@32003|Nitrosomonadales	28216|Betaproteobacteria	IQ	Short-chain dehydrogenase reductase SDR	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HKD3_k127_6170652_4	1163617.SCD_n01388	5.927e-08	61.0	COG0694@1|root,COG0694@2|Bacteria,1NHWB@1224|Proteobacteria,2VXQB@28216|Betaproteobacteria	28216|Betaproteobacteria	O	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins	-	-	-	ko:K19168	-	-	-	-	ko00000,ko02048	-	-	-	-
HKD3_k127_6170652_0	640081.Dsui_2677	0.0	1126.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,2VHQ3@28216|Betaproteobacteria,2KU6V@206389|Rhodocyclales	206389|Rhodocyclales	H	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate	pps	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
HKD3_k127_6170652_3	279714.FuraDRAFT_0789	8.821e-42	157.0	COG2944@1|root,COG2944@2|Bacteria,1N48U@1224|Proteobacteria,2VUHQ@28216|Betaproteobacteria,2KRAK@206351|Neisseriales	206351|Neisseriales	K	transcriptional regulator, XRE family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_31
HKD3_k127_6170652_2	580332.Slit_1630	2.664e-51	186.0	COG0613@1|root,COG0613@2|Bacteria,1MWIH@1224|Proteobacteria,2VHB2@28216|Betaproteobacteria,44VHP@713636|Nitrosomonadales	28216|Betaproteobacteria	S	DNA polymerase alpha chain like domain	-	GO:0003674,GO:0003824,GO:0005488,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0030145,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914,GO:0097657	3.1.3.97	ko:K07053	-	-	R00188,R11188	RC00078	ko00000,ko01000	-	-	-	PHP
HKD3_k127_6180481_6	78398.KS43_08055	1.846e-26	110.0	COG1181@1|root,COG1181@2|Bacteria,1MUTB@1224|Proteobacteria,1RMTM@1236|Gammaproteobacteria,1MRKK@122277|Pectobacterium	1236|Gammaproteobacteria	F	Cell wall formation	ddl	GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008716,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	iECO26_1355.ECO26_0095	Dala_Dala_lig_C,Dala_Dala_lig_N
HKD3_k127_6180481_5	748247.AZKH_3723	3.097e-45	173.0	COG1589@1|root,COG1589@2|Bacteria,1N0T7@1224|Proteobacteria,2VRMV@28216|Betaproteobacteria,2KW1D@206389|Rhodocyclales	206389|Rhodocyclales	D	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly	ftsQ	-	-	ko:K03589	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036	-	-	-	FtsQ,POTRA_1
HKD3_k127_6180481_1	1163617.SCD_n02480	5.02e-193	614.0	COG0849@1|root,COG0849@2|Bacteria,1MUSR@1224|Proteobacteria,2VGZP@28216|Betaproteobacteria	28216|Betaproteobacteria	D	Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring	ftsA	-	-	ko:K03590	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036,ko04812	-	-	-	FtsA,SHS2_FTSA
HKD3_k127_6180481_2	1288494.EBAPG3_28120	1.531e-162	526.0	COG0206@1|root,COG0206@2|Bacteria,1MV2X@1224|Proteobacteria,2VH0S@28216|Betaproteobacteria,372PE@32003|Nitrosomonadales	28216|Betaproteobacteria	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
HKD3_k127_6180481_3	292415.Tbd_0126	2.23e-121	402.0	COG0774@1|root,COG0774@2|Bacteria,1MV6T@1224|Proteobacteria,2VHI8@28216|Betaproteobacteria,1KSQK@119069|Hydrogenophilales	119069|Hydrogenophilales	M	Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis	lpxC	-	3.5.1.108	ko:K02535	ko00540,ko01100,map00540,map01100	M00060	R04587	RC00166,RC00300	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	LpxC
HKD3_k127_6180481_7	388051.AUFE01000028_gene5029	5.342e-07	57.0	COG4701@1|root,COG4701@2|Bacteria,1NHRC@1224|Proteobacteria,2VWI9@28216|Betaproteobacteria,1K86K@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Protein of unknown function (DUF721)	-	-	-	-	-	-	-	-	-	-	-	-	DUF721
HKD3_k127_6180481_4	1288494.EBAPG3_28070	9.915e-88	302.0	COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,2VKR8@28216|Betaproteobacteria,371UP@32003|Nitrosomonadales	28216|Betaproteobacteria	M	Peptidase family M23	-	-	3.4.24.75	ko:K08259	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_M23
HKD3_k127_6180481_0	1163617.SCD_n02474	0.0	1304.0	COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,2VHDH@28216|Betaproteobacteria	28216|Betaproteobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	-	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
HKD3_k127_6194284_4	1348657.M622_10235	2.555e-86	299.0	COG0628@1|root,COG0628@2|Bacteria,1MW0B@1224|Proteobacteria,2VHDW@28216|Betaproteobacteria,2KUGY@206389|Rhodocyclales	206389|Rhodocyclales	S	Pfam:UPF0118	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
HKD3_k127_6194284_6	76114.ebA7107	7.693e-48	181.0	COG0593@1|root,COG0593@2|Bacteria,1MVW6@1224|Proteobacteria,2VSFD@28216|Betaproteobacteria,2KWRT@206389|Rhodocyclales	206389|Rhodocyclales	L	Belongs to the DnaA family	-	-	-	ko:K10763	-	-	-	-	ko00000,ko03032	-	-	-	Bac_DnaA
HKD3_k127_6194284_5	1485544.JQKP01000007_gene1954	8.367e-49	183.0	COG1051@1|root,COG1051@2|Bacteria,1N03W@1224|Proteobacteria,2VRC0@28216|Betaproteobacteria,44VT0@713636|Nitrosomonadales	28216|Betaproteobacteria	F	Belongs to the Nudix hydrolase family. NudJ subfamily	nudJ	-	-	-	-	-	-	-	-	-	-	-	NUDIX
HKD3_k127_6194284_2	1266925.JHVX01000012_gene1683	3.691e-156	502.0	COG0482@1|root,COG0482@2|Bacteria,1MUT1@1224|Proteobacteria,2VJRR@28216|Betaproteobacteria,371SF@32003|Nitrosomonadales	28216|Betaproteobacteria	J	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34	mnmA	-	2.8.1.13	ko:K00566	ko04122,map04122	-	R08700	RC02313,RC02315	ko00000,ko00001,ko01000,ko03016	-	-	-	tRNA_Me_trans
HKD3_k127_6194284_7	887898.HMPREF0551_1845	5.159e-46	187.0	COG0629@1|root,COG0629@2|Bacteria,1RCWT@1224|Proteobacteria,2VR2Z@28216|Betaproteobacteria,1K2Q6@119060|Burkholderiaceae	28216|Betaproteobacteria	L	Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism	ssb	GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008047,GO:0008150,GO:0008152,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0030234,GO:0031668,GO:0033554,GO:0034641,GO:0042802,GO:0043085,GO:0043170,GO:0044093,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050790,GO:0050896,GO:0051716,GO:0065007,GO:0065009,GO:0071496,GO:0071704,GO:0090304,GO:0097159,GO:0098772,GO:1901360,GO:1901363	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
HKD3_k127_6194284_3	1288494.EBAPG3_25940	1.271e-138	454.0	COG0477@1|root,COG2814@2|Bacteria,1MVSH@1224|Proteobacteria,2VITN@28216|Betaproteobacteria,372X1@32003|Nitrosomonadales	28216|Betaproteobacteria	EGP	Sugar (and other) transporter	yajR	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
HKD3_k127_6194284_0	1095769.CAHF01000003_gene1026	0.0	1512.0	COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,2VIJE@28216|Betaproteobacteria,472IP@75682|Oxalobacteraceae	28216|Betaproteobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
HKD3_k127_6194284_8	1157635.KB892004_gene4631	7.988e-26	126.0	COG0454@1|root,COG0456@2|Bacteria,2IHUH@201174|Actinobacteria	201174|Actinobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_10,Acetyltransf_7
HKD3_k127_6194284_1	983917.RGE_14200	5.196e-210	661.0	COG2939@1|root,COG2939@2|Bacteria,1MW05@1224|Proteobacteria,2VK5M@28216|Betaproteobacteria	28216|Betaproteobacteria	E	PFAM peptidase S10 serine carboxypeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S10
HKD3_k127_6215227_2	94624.Bpet3948	3.627e-124	422.0	COG1063@1|root,COG1063@2|Bacteria,1MV9A@1224|Proteobacteria,2VMPR@28216|Betaproteobacteria,3T6V0@506|Alcaligenaceae	28216|Betaproteobacteria	C	Alcohol dehydrogenase GroES-like domain	idnD	-	1.1.1.264	ko:K00098	-	-	R05684	RC00089	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
HKD3_k127_6215227_4	864051.BurJ1DRAFT_3900	2.159e-70	246.0	COG2186@1|root,COG2186@2|Bacteria,1MY1K@1224|Proteobacteria,2VP3Y@28216|Betaproteobacteria	28216|Betaproteobacteria	K	Regulatory protein GntR HTH	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
HKD3_k127_6215227_6	1123368.AUIS01000032_gene1397	3.02e-59	215.0	COG0412@1|root,COG0412@2|Bacteria,1MW7S@1224|Proteobacteria,1RPGK@1236|Gammaproteobacteria,2NCSK@225057|Acidithiobacillales	225057|Acidithiobacillales	Q	Prolyl oligopeptidase family	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH,Peptidase_S9
HKD3_k127_6215227_7	640081.Dsui_1148	1.604e-55	218.0	COG0864@1|root,COG0864@2|Bacteria,1RK4R@1224|Proteobacteria,2VR6M@28216|Betaproteobacteria,2KWDQ@206389|Rhodocyclales	206389|Rhodocyclales	K	Transcriptional regulator	-	-	-	ko:K07722	-	-	-	-	ko00000,ko03000	-	-	-	NikR_C,RHH_1
HKD3_k127_6215227_0	1394178.AWOO02000027_gene5279	5.822e-193	610.0	COG4948@1|root,COG4948@2|Bacteria,2GJJR@201174|Actinobacteria,4EMET@85012|Streptosporangiales	201174|Actinobacteria	M	Mandelate racemase / muconate lactonizing enzyme, C-terminal domain	-	-	4.2.1.40	ko:K01706	ko00053,ko01100,map00053,map01100	-	R02752,R08056	RC00543	ko00000,ko00001,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
HKD3_k127_6215227_3	1096546.WYO_2189	1.882e-92	326.0	COG1028@1|root,COG1028@2|Bacteria,1MURZ@1224|Proteobacteria,2TQJ6@28211|Alphaproteobacteria,1JS8E@119045|Methylobacteriaceae	28211|Alphaproteobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	MA20_27190	-	1.1.1.30	ko:K00019,ko:K18335	ko00051,ko00072,ko00650,ko01100,ko01120,map00051,map00072,map00650,map01100,map01120	M00088	R01361,R10690	RC00089,RC00117	ko00000,ko00001,ko00002,ko01000	-	-	-	adh_short_C2
HKD3_k127_6215227_1	296591.Bpro_3959	3.827e-125	406.0	COG0179@1|root,COG0179@2|Bacteria,1MUPF@1224|Proteobacteria,2VI5Z@28216|Betaproteobacteria,4AA1T@80864|Comamonadaceae	28216|Betaproteobacteria	Q	PFAM fumarylacetoacetate (FAA) hydrolase	-	-	4.3.2.3	ko:K16856	ko00230,ko01100,map00230,map01100	-	R00776	RC00153,RC00379	ko00000,ko00001,ko01000	-	-	-	FAA_hydrolase
HKD3_k127_6215227_5	1217720.ALOX01000027_gene3694	5.843e-66	231.0	COG0637@1|root,COG0637@2|Bacteria,1QXCM@1224|Proteobacteria,2TXUC@28211|Alphaproteobacteria,2JZ36@204441|Rhodospirillales	204441|Rhodospirillales	S	Haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
HKD3_k127_6218379_20	1288494.EBAPG3_4470	9.445e-51	184.0	COG0290@1|root,COG0290@2|Bacteria,1RDD2@1224|Proteobacteria,2VQ19@28216|Betaproteobacteria,372YM@32003|Nitrosomonadales	28216|Betaproteobacteria	J	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins	infC	-	-	ko:K02520	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	IF3_C,IF3_N
HKD3_k127_6218379_26	580332.Slit_1735	7.054e-26	107.0	COG0291@1|root,COG0291@2|Bacteria,1N6V4@1224|Proteobacteria,2VVS9@28216|Betaproteobacteria,44W2J@713636|Nitrosomonadales	28216|Betaproteobacteria	J	Belongs to the bacterial ribosomal protein bL35 family	rpmI	-	-	ko:K02916	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L35p
HKD3_k127_6218379_19	323848.Nmul_A0490	2.972e-56	198.0	COG0292@1|root,COG0292@2|Bacteria,1RGU2@1224|Proteobacteria,2VRWF@28216|Betaproteobacteria,3738Y@32003|Nitrosomonadales	28216|Betaproteobacteria	J	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit	rplT	-	-	ko:K02887	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L20
HKD3_k127_6218379_10	1121004.ATVC01000010_gene1020	5.833e-143	469.0	COG0016@1|root,COG0016@2|Bacteria,1MVD7@1224|Proteobacteria,2VIM9@28216|Betaproteobacteria,2KPR5@206351|Neisseriales	206351|Neisseriales	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily	pheS	-	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Phe_tRNA-synt_N,tRNA-synt_2d
HKD3_k127_6218379_3	640081.Dsui_1963	1.796e-249	794.0	COG0072@1|root,COG0072@2|Bacteria,1MWKS@1224|Proteobacteria,2VHR1@28216|Betaproteobacteria,2KUJG@206389|Rhodocyclales	206389|Rhodocyclales	J	Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily	pheT	-	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,tRNA_bind
HKD3_k127_6218379_22	85643.Tmz1t_3019	7.804e-46	171.0	COG0776@1|root,COG0776@2|Bacteria,1RH5Z@1224|Proteobacteria,2VT12@28216|Betaproteobacteria,2KWPS@206389|Rhodocyclales	206389|Rhodocyclales	K	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control	ihfA	-	-	ko:K04764	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
HKD3_k127_6218379_21	1163617.SCD_n01115	1.921e-46	171.0	COG0789@1|root,COG0789@2|Bacteria,1RGYB@1224|Proteobacteria,2VSDF@28216|Betaproteobacteria	28216|Betaproteobacteria	K	PFAM regulatory protein, MerR	ycgE	-	-	-	-	-	-	-	-	-	-	-	MerR_1
HKD3_k127_6218379_12	1123368.AUIS01000032_gene1387	3.414e-112	376.0	COG3437@1|root,COG3437@2|Bacteria,1MUB8@1224|Proteobacteria,1RPH3@1236|Gammaproteobacteria,2NCPY@225057|Acidithiobacillales	225057|Acidithiobacillales	T	HD domain	-	-	-	ko:K13815	ko02020,ko02024,map02020,map02024	M00517	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HD,Response_reg
HKD3_k127_6218379_27	506534.Rhein_3136	1.404e-21	104.0	COG1320@1|root,COG1320@2|Bacteria,1MZ6Z@1224|Proteobacteria,1S8TM@1236|Gammaproteobacteria,1WYJD@135613|Chromatiales	135613|Chromatiales	P	PFAM Na H antiporter subunit	-	-	-	ko:K05564	-	-	-	-	ko00000,ko02000	2.A.63.1	-	-	PhaG_MnhG_YufB
HKD3_k127_6218379_28	1123053.AUDG01000004_gene3475	7.085e-21	99.0	COG2212@1|root,COG2212@2|Bacteria,1N8WJ@1224|Proteobacteria,1S8ZM@1236|Gammaproteobacteria,1WZ3A@135613|Chromatiales	135613|Chromatiales	P	Multiple resistance and pH regulation protein F	-	-	-	ko:K05563	-	-	-	-	ko00000,ko02000	2.A.63.1	-	-	MrpF_PhaF
HKD3_k127_6218379_24	1384054.N790_13045	2.953e-36	158.0	COG1863@1|root,COG1863@2|Bacteria,1RH9F@1224|Proteobacteria,1S66D@1236|Gammaproteobacteria,1XC0M@135614|Xanthomonadales	135614|Xanthomonadales	P	Na+/H+ ion antiporter subunit	-	-	-	-	-	-	-	-	-	-	-	-	MNHE
HKD3_k127_6218379_14	287.DR97_887	1.125e-107	373.0	COG0651@1|root,COG0651@2|Bacteria,1MURB@1224|Proteobacteria,1RQBG@1236|Gammaproteobacteria,1YDVC@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	CP	Proton-conducting membrane transporter	phaD	-	1.6.5.3	ko:K00342,ko:K05561,ko:K05568	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000,ko02000	2.A.63.1,2.A.63.2,3.D.1	-	-	Proton_antipo_M
HKD3_k127_6218379_25	391008.Smal_3730	2.401e-26	128.0	COG1006@1|root,COG1006@2|Bacteria,1RH8H@1224|Proteobacteria,1SA5H@1236|Gammaproteobacteria,1X6WN@135614|Xanthomonadales	135614|Xanthomonadales	P	NADH-ubiquinone oxidoreductase subunit 4L	phaC	-	-	ko:K05560	-	-	-	-	ko00000,ko02000	2.A.63.1	-	-	Oxidored_q2
HKD3_k127_6218379_1	1384056.N787_06240	1.423e-287	910.0	COG1009@1|root,COG2111@1|root,COG1009@2|Bacteria,COG2111@2|Bacteria,1MW2M@1224|Proteobacteria,1RNKN@1236|Gammaproteobacteria,1X40I@135614|Xanthomonadales	135614|Xanthomonadales	CP	Subunit A of antiporter complex involved in resistance to high concentrations of Na , K , Li and or alkali	ndhF	-	-	ko:K05559	-	-	-	-	ko00000,ko02000	2.A.63.1	-	-	DUF4040,MnhB,Proton_antipo_M,Proton_antipo_N
HKD3_k127_6218379_17	395019.Bmul_2202	2.304e-64	230.0	COG1556@1|root,COG1556@2|Bacteria,1R4TE@1224|Proteobacteria,2VJCF@28216|Betaproteobacteria,1K1I9@119060|Burkholderiaceae	28216|Betaproteobacteria	S	LUD domain	-	-	-	ko:K00782	-	-	-	-	ko00000	-	-	-	LUD_dom
HKD3_k127_6218379_11	1382304.JNIL01000001_gene1129	3.808e-118	393.0	COG0436@1|root,COG0436@2|Bacteria,1TP0J@1239|Firmicutes	1239|Firmicutes	E	Aminotransferase	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
HKD3_k127_6218379_6	264198.Reut_A1311	5.619e-192	610.0	COG1139@1|root,COG1139@2|Bacteria,1MV6J@1224|Proteobacteria,2VJ3Y@28216|Betaproteobacteria,1K165@119060|Burkholderiaceae	28216|Betaproteobacteria	C	4Fe-4S ferredoxin, iron-sulfur binding	-	-	-	ko:K18929	-	-	-	-	ko00000	-	-	-	DUF3390,Fer4_8,LUD_dom
HKD3_k127_6218379_13	76114.ebA4050	4.129e-108	357.0	COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,2VNV2@28216|Betaproteobacteria,2KUPV@206389|Rhodocyclales	206389|Rhodocyclales	C	Cysteine-rich domain	-	-	-	ko:K18928	-	-	-	-	ko00000	-	-	-	CCG
HKD3_k127_6218379_8	1163617.SCD_n00952	6.659e-160	539.0	COG1007@1|root,COG1007@2|Bacteria,1MV56@1224|Proteobacteria,2VHWX@28216|Betaproteobacteria	28216|Betaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoN	-	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
HKD3_k127_6218379_5	265072.Mfla_2049	6.234e-221	694.0	COG1008@1|root,COG1008@2|Bacteria,1MV7V@1224|Proteobacteria,2VIAX@28216|Betaproteobacteria,2KM01@206350|Nitrosomonadales	206350|Nitrosomonadales	C	TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain M	-	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q5_N,Proton_antipo_M
HKD3_k127_6218379_2	62928.azo1407	9.23e-285	889.0	COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,2VJ2J@28216|Betaproteobacteria,2KUJW@206389|Rhodocyclales	206389|Rhodocyclales	CP	COG1009 NADH ubiquinone oxidoreductase subunit 5 (chain L) Multisubunit Na H antiporter, MnhA subunit	nuoL	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M,Proton_antipo_N
HKD3_k127_6218379_23	883126.HMPREF9710_02248	7.821e-42	161.0	COG0713@1|root,COG0713@2|Bacteria,1RH0S@1224|Proteobacteria,2VSDV@28216|Betaproteobacteria,474JA@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoK	-	1.6.5.3	ko:K00340	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q2
HKD3_k127_6218379_16	292415.Tbd_1151	5.677e-66	231.0	COG0839@1|root,COG0839@2|Bacteria,1MWJV@1224|Proteobacteria,2VJ4G@28216|Betaproteobacteria,1KS7Z@119069|Hydrogenophilales	119069|Hydrogenophilales	C	NADH-ubiquinone/plastoquinone oxidoreductase chain 6	-	-	1.6.5.3	ko:K00339	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q3
HKD3_k127_6218379_15	261292.Nit79A3_2925	7.208e-88	291.0	COG1143@1|root,COG1143@2|Bacteria,1MV90@1224|Proteobacteria,2VIQP@28216|Betaproteobacteria,371MN@32003|Nitrosomonadales	28216|Betaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoI	-	1.6.5.3	ko:K00338	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer4
HKD3_k127_6218379_9	1122236.KB905141_gene1306	2.51e-153	509.0	COG1005@1|root,COG1005@2|Bacteria,1MU2R@1224|Proteobacteria,2VHD0@28216|Betaproteobacteria,2KM74@206350|Nitrosomonadales	206350|Nitrosomonadales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	nuoH	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
HKD3_k127_6218379_0	864073.HFRIS_018751	1.493e-313	980.0	COG1034@1|root,COG1034@2|Bacteria,1P8MN@1224|Proteobacteria,2VJYV@28216|Betaproteobacteria,4731E@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	NADH-quinone oxidoreductase	nuoG	-	1.6.5.3	ko:K00336	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer2_4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
HKD3_k127_6218379_4	667632.KB890198_gene1039	2.647e-230	728.0	COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,2VJJ1@28216|Betaproteobacteria,1K079@119060|Burkholderiaceae	28216|Betaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain	nuoF	-	1.6.5.3	ko:K00335	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_51K,NADH_4Fe-4S,SLBB
HKD3_k127_6218379_18	1266925.JHVX01000013_gene1667	9.983e-62	231.0	COG1905@1|root,COG1905@2|Bacteria,1MWS2@1224|Proteobacteria,2VQD9@28216|Betaproteobacteria,371SU@32003|Nitrosomonadales	28216|Betaproteobacteria	C	Thioredoxin-like [2Fe-2S] ferredoxin	nuoE	-	1.6.5.3	ko:K00334	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
HKD3_k127_6218379_7	1122236.KB905141_gene1310	2.461e-188	590.0	COG0649@1|root,COG0649@2|Bacteria,1MVIN@1224|Proteobacteria,2VHEC@28216|Betaproteobacteria,2KMAZ@206350|Nitrosomonadales	206350|Nitrosomonadales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoD	-	1.6.5.3	ko:K00333	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa
HKD3_k127_6232686_8	1304883.KI912532_gene254	6.288e-116	384.0	COG0142@1|root,COG0142@2|Bacteria,1MUK6@1224|Proteobacteria,2VHX4@28216|Betaproteobacteria,2KV65@206389|Rhodocyclales	206389|Rhodocyclales	H	Belongs to the FPP GGPP synthase family	ispB	-	2.5.1.90	ko:K02523	ko00900,ko01110,map00900,map01110	-	R09248	RC00279	ko00000,ko00001,ko01000,ko01006	-	-	-	polyprenyl_synt
HKD3_k127_6232686_13	62928.azo3167	9.306e-46	168.0	COG0261@1|root,COG0261@2|Bacteria,1MZEW@1224|Proteobacteria,2VSHZ@28216|Betaproteobacteria,2KWM1@206389|Rhodocyclales	206389|Rhodocyclales	J	This protein binds to 23S rRNA in the presence of protein L20	rplU	-	-	ko:K02888	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L21p
HKD3_k127_6232686_15	1562701.BBOF01000069_gene2238	7.997e-32	134.0	COG0211@1|root,COG0211@2|Bacteria,1MZGH@1224|Proteobacteria,2VU4W@28216|Betaproteobacteria,1K8IM@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Belongs to the bacterial ribosomal protein bL27 family	rpmA	-	-	ko:K02899	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27
HKD3_k127_6232686_10	1163617.SCD_n00813	1.964e-95	340.0	COG0795@1|root,COG0795@2|Bacteria,1MVW3@1224|Proteobacteria,2VHA1@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Permease, YjgP YjgQ family	lptG	-	-	ko:K11720	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko02000	1.B.42.1	-	-	YjgP_YjgQ
HKD3_k127_6232686_11	159087.Daro_3081	6.358e-85	295.0	COG0795@1|root,COG0795@2|Bacteria,1MUF2@1224|Proteobacteria,2VH9C@28216|Betaproteobacteria,2KVN9@206389|Rhodocyclales	206389|Rhodocyclales	S	Permease YjgP YjgQ family	-	-	-	ko:K07091	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko02000	1.B.42.1	-	-	YjgP_YjgQ
HKD3_k127_6232686_3	243365.CV_2914	1.671e-209	662.0	COG0260@1|root,COG0260@2|Bacteria,1MUF9@1224|Proteobacteria,2VH79@28216|Betaproteobacteria,2KQ8S@206351|Neisseriales	206351|Neisseriales	E	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	pepA	-	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17,Peptidase_M17_N
HKD3_k127_6232686_14	292415.Tbd_0579	7.517e-38	146.0	COG2927@1|root,COG2927@2|Bacteria,1MZ3V@1224|Proteobacteria,2VTYC@28216|Betaproteobacteria	28216|Betaproteobacteria	L	dna polymerase III (Chi subunit)	holC	-	2.7.7.7	ko:K02339	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_chi
HKD3_k127_6232686_5	582744.Msip34_1530	7.293e-155	497.0	COG2876@1|root,COG2876@2|Bacteria,1QVAD@1224|Proteobacteria,2VH85@28216|Betaproteobacteria	28216|Betaproteobacteria	E	phospho-2-dehydro-3-deoxyheptonate aldolase	aroF	-	2.5.1.54	ko:K03856	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_1
HKD3_k127_6232686_0	1095769.CAHF01000001_gene3521	0.0	1265.0	COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,2VH5Z@28216|Betaproteobacteria,4724U@75682|Oxalobacteraceae	28216|Betaproteobacteria	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
HKD3_k127_6232686_9	404380.Gbem_1224	1.135e-112	378.0	COG0477@1|root,COG2814@2|Bacteria,1QTX0@1224|Proteobacteria,42PT2@68525|delta/epsilon subdivisions,2WJ6Q@28221|Deltaproteobacteria	28221|Deltaproteobacteria	EGP	Major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
HKD3_k127_6232686_12	557598.LHK_02409	3.875e-79	291.0	COG2933@1|root,COG2933@2|Bacteria,1MWBM@1224|Proteobacteria,2VJ71@28216|Betaproteobacteria,2KSUE@206351|Neisseriales	206351|Neisseriales	J	FtsJ-like methyltransferase	-	-	2.1.1.186	ko:K06968	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ
HKD3_k127_6232686_7	977880.RALTA_A1723	1.245e-121	415.0	COG3191@1|root,COG3191@2|Bacteria,1MWDP@1224|Proteobacteria,2VKAV@28216|Betaproteobacteria,1K3B4@119060|Burkholderiaceae	28216|Betaproteobacteria	EQ	PFAM peptidase S58, DmpA	dmpA	-	3.4.11.19	ko:K01266	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S58
HKD3_k127_6232686_6	402626.Rpic_1255	3.973e-146	481.0	COG1173@1|root,COG1173@2|Bacteria,1MWMX@1224|Proteobacteria,2VIGP@28216|Betaproteobacteria,1K3XX@119060|Burkholderiaceae	28216|Betaproteobacteria	EP	PFAM binding-protein-dependent transport systems inner membrane component	gsiD	-	-	ko:K13891	ko02010,map02010	M00348	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.11	-	-	BPD_transp_1,OppC_N
HKD3_k127_6232686_4	1249634.D781_1462	1.34e-156	498.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,1RNJ1@1236|Gammaproteobacteria,400X5@613|Serratia	1236|Gammaproteobacteria	U	COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components	gsiC	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	ko:K13890	ko02010,map02010	M00348	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.11	-	ic_1306.c0916	BPD_transp_1
HKD3_k127_6232686_2	1175306.GWL_12740	5.033e-244	762.0	COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,2VHXW@28216|Betaproteobacteria,4764T@75682|Oxalobacteraceae	28216|Betaproteobacteria	E	ABC-type dipeptide transport system, periplasmic	gsiB_6	-	-	ko:K02035,ko:K13889	ko02010,ko02024,map02010,map02024	M00239,M00348	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.11	-	-	SBP_bac_5
HKD3_k127_6232686_1	360910.BAV1158	7.008e-284	886.0	COG1123@1|root,COG4172@2|Bacteria,1MU09@1224|Proteobacteria,2VH5T@28216|Betaproteobacteria,3T2UE@506|Alcaligenaceae	28216|Betaproteobacteria	P	Belongs to the ABC transporter superfamily	gsiA	-	-	ko:K02031,ko:K02032,ko:K13892	ko02010,ko02024,map02010,map02024	M00239,M00348	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.11	-	-	ABC_tran,oligo_HPY
HKD3_k127_6263068_20	1349767.GJA_37	3.366e-74	256.0	COG4166@1|root,COG4166@2|Bacteria,1R87R@1224|Proteobacteria,2VKFJ@28216|Betaproteobacteria,47408@75682|Oxalobacteraceae	28216|Betaproteobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_5
HKD3_k127_6263068_44	1156935.QWE_18448	0.0005907	48.0	COG3895@1|root,COG3895@2|Bacteria	2|Bacteria	O	Periplasmic Protein	mliC	GO:0003674,GO:0004857,GO:0005575,GO:0005623,GO:0008150,GO:0009279,GO:0016020,GO:0019867,GO:0030234,GO:0030312,GO:0030313,GO:0031975,GO:0043086,GO:0044092,GO:0044462,GO:0044464,GO:0050790,GO:0060241,GO:0065007,GO:0065009,GO:0071944,GO:0098772	-	-	-	-	-	-	-	-	-	-	MliC
HKD3_k127_6263068_1	748247.AZKH_1229	2.824e-212	679.0	COG4579@1|root,COG4579@2|Bacteria,1MVRB@1224|Proteobacteria,2VJMA@28216|Betaproteobacteria,2KUNY@206389|Rhodocyclales	206389|Rhodocyclales	F	Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation	aceK	-	2.7.11.5	ko:K00906	-	-	-	-	ko00000,ko01000	-	-	-	AceK
HKD3_k127_6263068_32	522306.CAP2UW1_3094	3.127e-41	162.0	29AFQ@1|root,2ZXFW@2|Bacteria,1RGFB@1224|Proteobacteria,2VQD0@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Transcription factor zinc-finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-TFIIB
HKD3_k127_6263068_43	987059.RBXJA2T_03683	0.0004793	45.0	2EGH0@1|root,33A93@2|Bacteria,1NHBI@1224|Proteobacteria,2VY3R@28216|Betaproteobacteria,1KMU8@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Protein of unknown function (DUF3149)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3149
HKD3_k127_6263068_15	1149133.ppKF707_0278	1.321e-95	323.0	COG2321@1|root,COG2321@2|Bacteria,1MU4U@1224|Proteobacteria,1RMF8@1236|Gammaproteobacteria,1YDXN@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	S	Putative neutral zinc metallopeptidase	ypfJ	-	-	ko:K07054	-	-	-	-	ko00000	-	-	-	Zn_peptidase
HKD3_k127_6263068_30	649831.L083_3337	7.09e-44	184.0	COG0604@1|root,COG0604@2|Bacteria,2GIS3@201174|Actinobacteria,4D9SB@85008|Micromonosporales	201174|Actinobacteria	C	Zinc-binding dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N_2
HKD3_k127_6263068_14	414684.RC1_3371	3.001e-103	349.0	COG0627@1|root,COG0627@2|Bacteria,1QIRQ@1224|Proteobacteria,2TUU5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Putative esterase	-	-	-	-	-	-	-	-	-	-	-	-	Esterase
HKD3_k127_6263068_39	1247726.MIM_c24360	1.537e-25	112.0	COG0450@1|root,COG0450@2|Bacteria,1MWPY@1224|Proteobacteria,2VKCF@28216|Betaproteobacteria,3T1U2@506|Alcaligenaceae	28216|Betaproteobacteria	O	Alkyl hydroperoxide reductase	ahpC	-	1.11.1.15	ko:K03386	ko04214,map04214	-	-	-	ko00000,ko00001,ko01000,ko04147	-	-	-	AhpC-TSA
HKD3_k127_6263068_34	438753.AZC_1051	4.907e-40	153.0	COG0450@1|root,COG0450@2|Bacteria,1MWPY@1224|Proteobacteria,2TV43@28211|Alphaproteobacteria,3F1WG@335928|Xanthobacteraceae	28211|Alphaproteobacteria	O	Redoxin	ahpC	-	1.11.1.15	ko:K03386	ko04214,map04214	-	-	-	ko00000,ko00001,ko01000,ko04147	-	-	-	1-cysPrx_C,AhpC-TSA
HKD3_k127_6263068_28	94624.Bpet0025	5.343e-49	184.0	COG2940@1|root,COG2940@2|Bacteria,1MWFB@1224|Proteobacteria,2VSZY@28216|Betaproteobacteria,3T3K6@506|Alcaligenaceae	28216|Betaproteobacteria	S	SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain	-	-	-	ko:K07117	-	-	-	-	ko00000	-	-	-	SET
HKD3_k127_6263068_19	395019.Bmul_6301	1.269e-75	270.0	COG2807@1|root,COG2807@2|Bacteria,1QUCZ@1224|Proteobacteria,2WHKR@28216|Betaproteobacteria	28216|Betaproteobacteria	P	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD3_k127_6263068_7	159087.Daro_4128	4.806e-163	518.0	COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,2VJI3@28216|Betaproteobacteria,2KVD7@206389|Rhodocyclales	206389|Rhodocyclales	E	Pyridoxal-phosphate dependent enzyme	-	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HKD3_k127_6263068_36	748247.AZKH_2012	3.869e-39	157.0	COG3712@1|root,COG3712@2|Bacteria,1N941@1224|Proteobacteria,2VIKR@28216|Betaproteobacteria,2KVI1@206389|Rhodocyclales	28216|Betaproteobacteria	PT	iron ion homeostasis	-	-	-	-	-	-	-	-	-	-	-	-	FecR
HKD3_k127_6263068_27	296591.Bpro_4325	1.556e-51	186.0	COG3266@1|root,COG3266@2|Bacteria,1QYJ8@1224|Proteobacteria,2WHG3@28216|Betaproteobacteria	28216|Betaproteobacteria	S	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_6263068_12	522306.CAP2UW1_2374	1.778e-108	360.0	COG0679@1|root,COG0679@2|Bacteria,1MY23@1224|Proteobacteria,2VI9B@28216|Betaproteobacteria,1KQZ7@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	S	Membrane transport protein	-	-	-	ko:K07088	-	-	-	-	ko00000	-	-	-	Mem_trans
HKD3_k127_6263068_21	523791.Kkor_0965	2.965e-72	250.0	COG0302@1|root,COG0302@2|Bacteria,1MY3N@1224|Proteobacteria,1RMQM@1236|Gammaproteobacteria,1XIJW@135619|Oceanospirillales	135619|Oceanospirillales	H	catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water	folE	-	3.5.4.16	ko:K01495	ko00790,ko01100,map00790,map01100	M00126,M00841,M00842,M00843	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	-	GTP_cyclohydroI
HKD3_k127_6263068_26	272568.GDI1375	3.122e-53	211.0	COG0793@1|root,COG0793@2|Bacteria,1N4T9@1224|Proteobacteria	1224|Proteobacteria	M	Aspartyl protease	-	-	-	-	-	-	-	-	-	-	-	-	Asp_protease_2,PDZ_2
HKD3_k127_6263068_13	1504672.669786368	4.178e-105	351.0	COG4221@1|root,COG4221@2|Bacteria,1MWXS@1224|Proteobacteria,2VHSZ@28216|Betaproteobacteria,4AANF@80864|Comamonadaceae	28216|Betaproteobacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HKD3_k127_6263068_10	1005048.CFU_1802	6.236e-139	474.0	COG0477@1|root,COG2814@2|Bacteria,1QTX0@1224|Proteobacteria,2VHUR@28216|Betaproteobacteria,47319@75682|Oxalobacteraceae	28216|Betaproteobacteria	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_3
HKD3_k127_6263068_2	864073.HFRIS_015371	2.261e-209	662.0	COG2233@1|root,COG2233@2|Bacteria,1MUN9@1224|Proteobacteria,2VI3I@28216|Betaproteobacteria,475TI@75682|Oxalobacteraceae	28216|Betaproteobacteria	F	Permease family	rutG	-	-	ko:K02824	-	-	-	-	ko00000,ko02000	2.A.40.1.1,2.A.40.1.2	-	-	Xan_ur_permease
HKD3_k127_6263068_22	1123392.AQWL01000002_gene1997	1.387e-71	247.0	COG3132@1|root,COG3132@2|Bacteria,1RA13@1224|Proteobacteria,2VQGS@28216|Betaproteobacteria,1KSRP@119069|Hydrogenophilales	119069|Hydrogenophilales	S	Protein of unknown function, DUF480	-	-	-	-	-	-	-	-	-	-	-	-	DUF480
HKD3_k127_6263068_41	269796.Rru_A1783	2.852e-07	64.0	2EJPN@1|root,33DEG@2|Bacteria,1NJ0G@1224|Proteobacteria,2UKKF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_6263068_9	450851.PHZ_c1121	1.376e-139	450.0	COG4257@1|root,COG4257@2|Bacteria,1QR8W@1224|Proteobacteria,2TRQ1@28211|Alphaproteobacteria	28211|Alphaproteobacteria	V	Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid	-	-	-	ko:K18235	-	-	-	-	ko00000,ko01000,ko01504	-	-	-	-
HKD3_k127_6263068_4	1121430.JMLG01000004_gene924	2.757e-206	668.0	COG4909@1|root,COG4909@2|Bacteria,1TPU7@1239|Firmicutes,24AFR@186801|Clostridia,26436@186807|Peptococcaceae	186801|Clostridia	Q	Dehydratase large subunit	dhaB	-	4.2.1.28,4.2.1.30	ko:K01699,ko:K06120	ko00561,ko00640,map00561,map00640	-	R01047,R02376	RC00429,RC00707	ko00000,ko00001,ko01000	-	-	-	Dehydratase_LU
HKD3_k127_6263068_31	634956.Geoth_1928	3.979e-42	178.0	COG4909@1|root,COG4909@2|Bacteria,1UT3J@1239|Firmicutes,4HFWN@91061|Bacilli	91061|Bacilli	Q	Dehydratase	pduD	-	4.2.1.28	ko:K13919	ko00640,map00640	-	R02376	RC00707	ko00000,ko00001,ko01000	-	-	-	Dehydratase_MU
HKD3_k127_6263068_40	1121430.JMLG01000004_gene926	1.327e-21	103.0	COG4910@1|root,COG4910@2|Bacteria,1V5ZV@1239|Firmicutes,24KHN@186801|Clostridia,2658B@186807|Peptococcaceae	186801|Clostridia	Q	Dehydratase small subunit	pduE	-	4.2.1.28,4.2.1.30	ko:K06122,ko:K13920	ko00561,ko00640,map00561,map00640	-	R01047,R02376	RC00429,RC00707	ko00000,ko00001,ko01000	-	-	-	Dehydratase_SU
HKD3_k127_6263068_25	365046.Rta_23850	4.294e-54	200.0	COG4119@1|root,COG4119@2|Bacteria,1RHCE@1224|Proteobacteria,2VV6B@28216|Betaproteobacteria	28216|Betaproteobacteria	L	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
HKD3_k127_6263068_29	795666.MW7_2201	4.552e-45	169.0	COG1186@1|root,COG1186@2|Bacteria,1RH75@1224|Proteobacteria,2VSE7@28216|Betaproteobacteria,1K7MJ@119060|Burkholderiaceae	28216|Betaproteobacteria	J	peptide chain release factor	yaeJ	-	-	ko:K15034	-	-	-	-	ko00000,ko03012	-	-	-	RF-1
HKD3_k127_6263068_6	1366050.N234_28690	7.406e-182	598.0	COG2079@1|root,COG2079@2|Bacteria,1NECN@1224|Proteobacteria,2VN65@28216|Betaproteobacteria,1K3BE@119060|Burkholderiaceae	28216|Betaproteobacteria	S	MmgE/PrpD family	-	-	-	-	-	-	-	-	-	-	-	-	MmgE_PrpD
HKD3_k127_6263068_11	312153.Pnuc_0483	3.729e-116	399.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VIGV@28216|Betaproteobacteria,1KBN9@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HKD3_k127_6263068_35	414684.RC1_1514	3.728e-39	159.0	COG0500@1|root,COG0500@2|Bacteria,1QU8V@1224|Proteobacteria,2UB0B@28211|Alphaproteobacteria,2JVQE@204441|Rhodospirillales	204441|Rhodospirillales	Q	Histone methylation protein DOT1	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
HKD3_k127_6263068_42	105559.Nwat_0860	5.069e-06	52.0	COG4446@1|root,COG4446@2|Bacteria,1N31A@1224|Proteobacteria,1RRKY@1236|Gammaproteobacteria,1X0TK@135613|Chromatiales	135613|Chromatiales	S	Protein of unknown function (DUF1499)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1499
HKD3_k127_6263068_38	425104.Ssed_1389	2.774e-30	130.0	COG4094@1|root,COG4094@2|Bacteria,1RDHB@1224|Proteobacteria,1S78U@1236|Gammaproteobacteria,2QD6D@267890|Shewanellaceae	1236|Gammaproteobacteria	S	NnrU protein	nnrU	-	-	-	-	-	-	-	-	-	-	-	NnrU
HKD3_k127_6263068_23	1385517.N800_10410	5.437e-66	231.0	COG0705@1|root,COG0705@2|Bacteria,1RD88@1224|Proteobacteria,1S5NF@1236|Gammaproteobacteria,1X4YW@135614|Xanthomonadales	135614|Xanthomonadales	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
HKD3_k127_6263068_16	1380391.JIAS01000020_gene1621	1.728e-90	306.0	COG0625@1|root,COG0625@2|Bacteria,1N8XH@1224|Proteobacteria,2TTHQ@28211|Alphaproteobacteria,2JPQW@204441|Rhodospirillales	204441|Rhodospirillales	O	Glutathione S-transferase, C-terminal domain	-	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C_3
HKD3_k127_6263068_37	243233.MCA2572	7.978e-33	130.0	COG1833@1|root,COG1833@2|Bacteria,1N8Y1@1224|Proteobacteria,1SDIB@1236|Gammaproteobacteria,1XGWK@135618|Methylococcales	135618|Methylococcales	S	Domain of unknown function DUF123	-	-	-	-	-	-	-	-	-	-	-	-	DUF123
HKD3_k127_6263068_24	420662.Mpe_A0662	1.397e-63	228.0	COG1652@1|root,COG1652@2|Bacteria,1RD8K@1224|Proteobacteria,2VR7C@28216|Betaproteobacteria,1KM1Q@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Lysin motif	ygaU	-	-	-	-	-	-	-	-	-	-	-	BON,LysM
HKD3_k127_6263068_5	398527.Bphyt_5013	5.61e-201	635.0	COG0215@1|root,COG0215@2|Bacteria,1MV8H@1224|Proteobacteria,2VZEK@28216|Betaproteobacteria,1K56M@119060|Burkholderiaceae	28216|Betaproteobacteria	J	tRNA synthetases class I (C) catalytic domain	-	-	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1e
HKD3_k127_6263068_8	1121033.AUCF01000016_gene5418	1.522e-145	479.0	COG0179@1|root,COG0179@2|Bacteria,1MV0V@1224|Proteobacteria,2TQYU@28211|Alphaproteobacteria,2JQ2T@204441|Rhodospirillales	204441|Rhodospirillales	Q	Fumarylacetoacetate (FAA) hydrolase family	-	-	3.7.1.2	ko:K16171	ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120	M00044	R01364	RC00326,RC00446	ko00000,ko00001,ko00002,ko01000	-	-	-	FAA_hydrolase
HKD3_k127_6263068_18	342113.DM82_2513	5.016e-78	267.0	COG2096@1|root,COG2096@2|Bacteria,1RDUF@1224|Proteobacteria,2VQ7P@28216|Betaproteobacteria,1K1TA@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Adenosyltransferase	yvqK	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005525,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016043,GO:0016740,GO:0016765,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019003,GO:0019438,GO:0019538,GO:0022607,GO:0030091,GO:0030554,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0033013,GO:0033014,GO:0034641,GO:0035639,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0051186,GO:0051188,GO:0051259,GO:0051260,GO:0065003,GO:0070206,GO:0070207,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.5.1.17	ko:K00798	ko00860,ko01100,map00860,map01100	M00122	R01492,R05220,R07268	RC00533	ko00000,ko00001,ko00002,ko01000	-	-	-	Cob_adeno_trans
HKD3_k127_6263068_0	279714.FuraDRAFT_2225	4.542e-260	812.0	COG0318@1|root,COG0318@2|Bacteria,1MUMC@1224|Proteobacteria,2VIJ8@28216|Betaproteobacteria,2KQG8@206351|Neisseriales	206351|Neisseriales	IQ	AMP-binding enzyme C-terminal domain	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
HKD3_k127_6263068_17	342113.DM82_4802	1.415e-86	296.0	COG1024@1|root,COG1024@2|Bacteria,1MUJ7@1224|Proteobacteria,2VIP5@28216|Betaproteobacteria,1K20F@119060|Burkholderiaceae	28216|Betaproteobacteria	I	enoyl-CoA hydratase	fadB3	-	-	-	-	-	-	-	-	-	-	-	ECH_1
HKD3_k127_6263068_33	1123399.AQVE01000001_gene754	2.165e-40	152.0	COG3162@1|root,COG3162@2|Bacteria,1N9T2@1224|Proteobacteria,1SSS2@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function, DUF485	-	-	-	-	-	-	-	-	-	-	-	-	DUF485
HKD3_k127_6263068_3	1122951.ATUE01000009_gene418	9.25e-207	655.0	COG4147@1|root,COG4147@2|Bacteria,1MVJ8@1224|Proteobacteria,1RN0R@1236|Gammaproteobacteria,3NJC9@468|Moraxellaceae	1236|Gammaproteobacteria	S	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	actP	-	-	ko:K14393	-	-	-	-	ko00000,ko02000	2.A.21.7	-	-	SSF
HKD3_k127_6332221_32	351607.Acel_0233	3.233e-60	216.0	COG3391@1|root,COG3391@2|Bacteria,2I1IX@201174|Actinobacteria,4EVVE@85013|Frankiales	2|Bacteria	S	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,DUF11,DUF4114,Lactonase,Phage-tail_3
HKD3_k127_6332221_13	1454004.AW11_00571	8.981e-127	412.0	COG0204@1|root,COG0204@2|Bacteria,1MVWG@1224|Proteobacteria,2VI6Y@28216|Betaproteobacteria	28216|Betaproteobacteria	I	Acyl-transferase	yihG	-	-	-	-	-	-	-	-	-	-	-	Acyltransferase
HKD3_k127_6332221_41	748247.AZKH_2760	8.925e-24	111.0	COG1514@1|root,COG1514@2|Bacteria,1RDB2@1224|Proteobacteria,2VTZU@28216|Betaproteobacteria,2KWXS@206389|Rhodocyclales	206389|Rhodocyclales	J	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester	ligT	-	3.1.4.58	ko:K01975	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	LigT_PEase
HKD3_k127_6332221_23	316055.RPE_2935	2.516e-81	276.0	COG1011@1|root,COG1011@2|Bacteria,1MU1H@1224|Proteobacteria,2TQVC@28211|Alphaproteobacteria,3JS84@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Haloacid dehalogenase-like hydrolase	MA20_30570	-	3.8.1.2	ko:K01560	ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120	-	R05287	RC00697	ko00000,ko00001,ko01000	-	-	-	HAD_2
HKD3_k127_6332221_19	640081.Dsui_3504	5.636e-96	323.0	COG2897@1|root,COG2897@2|Bacteria,1MW4B@1224|Proteobacteria,2VHAX@28216|Betaproteobacteria,2KVPB@206389|Rhodocyclales	206389|Rhodocyclales	P	Rhodanese Homology Domain	tst	-	2.8.1.1,2.8.1.2	ko:K01011	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko01000	-	-	-	Rhodanese
HKD3_k127_6332221_29	292415.Tbd_0883	1.806e-65	235.0	COG0697@1|root,COG0697@2|Bacteria,1MZXM@1224|Proteobacteria,2VK90@28216|Betaproteobacteria	28216|Betaproteobacteria	EG	of the drug metabolite transporter (DMT) superfamily	-	-	-	ko:K15270	-	-	-	-	ko00000,ko02000	2.A.7.3.7	-	-	EamA
HKD3_k127_6332221_39	983917.RGE_13100	3.161e-28	120.0	2E3B5@1|root,32YAP@2|Bacteria,1N7KQ@1224|Proteobacteria,2VWEG@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Protein of unknown function (DUF2721)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2721
HKD3_k127_6332221_26	189753.AXAS01000041_gene2534	2.513e-70	260.0	COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,2TSG1@28211|Alphaproteobacteria,3JSYZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
HKD3_k127_6332221_6	1000565.METUNv1_02498	1.71e-185	587.0	COG4638@1|root,COG4638@2|Bacteria,1MWXW@1224|Proteobacteria,2VH18@28216|Betaproteobacteria,2KUAN@206389|Rhodocyclales	206389|Rhodocyclales	P	COG4638 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit	-	-	-	-	-	-	-	-	-	-	-	-	Rieske,Ring_hydroxyl_A
HKD3_k127_6332221_42	1454004.AW11_00765	2.939e-18	88.0	COG1722@1|root,COG1722@2|Bacteria,1PTYP@1224|Proteobacteria,2VVQV@28216|Betaproteobacteria,1KQ52@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseB	-	3.1.11.6	ko:K03602	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_S
HKD3_k127_6332221_20	159087.Daro_3060	1.278e-90	311.0	COG0142@1|root,COG0142@2|Bacteria,1MWNG@1224|Proteobacteria,2VHQV@28216|Betaproteobacteria,2KV0J@206389|Rhodocyclales	206389|Rhodocyclales	H	Belongs to the FPP GGPP synthase family	ispA	-	2.5.1.1,2.5.1.10	ko:K00795	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364	R01658,R02003	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
HKD3_k127_6332221_1	228410.NE1161	2.701e-287	899.0	COG1154@1|root,COG1154@2|Bacteria,1MUSJ@1224|Proteobacteria,2VHXG@28216|Betaproteobacteria,372IT@32003|Nitrosomonadales	28216|Betaproteobacteria	F	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)	dxs	-	2.2.1.7	ko:K01662	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	M00096	R05636	RC00032	ko00000,ko00001,ko00002,ko01000	-	-	-	DXP_synthase_N,Transket_pyr,Transketolase_C
HKD3_k127_6332221_21	667632.KB890166_gene1381	1.843e-90	310.0	COG1469@1|root,COG1469@2|Bacteria,1MV1B@1224|Proteobacteria,2VIC9@28216|Betaproteobacteria,1K2E8@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Converts GTP to 7,8-dihydroneopterin triphosphate	folE2	-	3.5.4.16	ko:K09007	ko00790,ko01100,map00790,map01100	M00126	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	-	GCHY-1
HKD3_k127_6332221_27	265072.Mfla_0438	8.934e-68	239.0	COG0518@1|root,COG0518@2|Bacteria,1MUDH@1224|Proteobacteria,2VJEI@28216|Betaproteobacteria,2KKPM@206350|Nitrosomonadales	206350|Nitrosomonadales	F	PFAM Glutamine amidotransferase class-I	-	-	-	-	-	-	-	-	-	-	-	-	GATase
HKD3_k127_6332221_5	1123392.AQWL01000003_gene305	8.029e-195	625.0	COG0323@1|root,COG0323@2|Bacteria,1MV61@1224|Proteobacteria,2VIBW@28216|Betaproteobacteria,1KS5U@119069|Hydrogenophilales	119069|Hydrogenophilales	L	DNA mismatch repair protein, C-terminal domain	-	-	-	ko:K03572	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	DNA_mis_repair,HATPase_c_3,MutL_C
HKD3_k127_6332221_16	1031711.RSPO_c00887	5.816e-106	362.0	COG0324@1|root,COG0324@2|Bacteria,1MUB2@1224|Proteobacteria,2VHEP@28216|Betaproteobacteria,1K1TT@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)	miaA	-	2.5.1.75	ko:K00791	ko00908,ko01100,ko01110,map00908,map01100,map01110	-	R01122	RC02820	ko00000,ko00001,ko01000,ko01006,ko03016	-	-	-	IPPT
HKD3_k127_6332221_45	391612.CY0110_22914	1.191e-09	72.0	COG5001@1|root,COG5001@2|Bacteria,1G0SY@1117|Cyanobacteria,3KGRE@43988|Cyanothece	1117|Cyanobacteria	T	GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL,FHA,GGDEF,PAS,PAS_8,PAS_9
HKD3_k127_6332221_2	159087.Daro_0861	3.526e-239	747.0	COG0065@1|root,COG0065@2|Bacteria,1MVYR@1224|Proteobacteria,2VHSH@28216|Betaproteobacteria,2KVD8@206389|Rhodocyclales	206389|Rhodocyclales	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuC	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
HKD3_k127_6332221_46	1434929.X946_401	0.0005888	46.0	2BGC5@1|root,32A9V@2|Bacteria,1PYM6@1224|Proteobacteria,2WDT3@28216|Betaproteobacteria,1KAYH@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Entericidin EcnA/B family	-	-	-	-	-	-	-	-	-	-	-	-	Entericidin
HKD3_k127_6332221_15	1095769.CAHF01000011_gene2553	1.108e-106	370.0	COG0066@1|root,COG0066@2|Bacteria,1MVXB@1224|Proteobacteria,2VIJC@28216|Betaproteobacteria,472UP@75682|Oxalobacteraceae	28216|Betaproteobacteria	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuD	-	4.2.1.33,4.2.1.35	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R10170	RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase_C
HKD3_k127_6332221_10	395494.Galf_0493	4.504e-158	506.0	COG0473@1|root,COG0473@2|Bacteria,1MUH4@1224|Proteobacteria,2VH2M@28216|Betaproteobacteria,44VCP@713636|Nitrosomonadales	28216|Betaproteobacteria	C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate	leuB	GO:0003674,GO:0003824,GO:0003862,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
HKD3_k127_6332221_8	323848.Nmul_A1917	6.286e-179	567.0	COG0136@1|root,COG0136@2|Bacteria,1MUHG@1224|Proteobacteria,2VH2N@28216|Betaproteobacteria,3729Z@32003|Nitrosomonadales	28216|Betaproteobacteria	E	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate	asd	-	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
HKD3_k127_6332221_14	375286.mma_2167	1.727e-125	436.0	COG3170@1|root,COG3170@2|Bacteria,1MXV7@1224|Proteobacteria,2VHX1@28216|Betaproteobacteria,473WU@75682|Oxalobacteraceae	28216|Betaproteobacteria	NU	LysM domain	fimV	-	-	ko:K08086	-	-	-	-	ko00000	-	-	-	LysM
HKD3_k127_6332221_18	1163617.SCD_n00879	1.616e-96	322.0	COG0101@1|root,COG0101@2|Bacteria,1MUYI@1224|Proteobacteria,2VI0R@28216|Betaproteobacteria	28216|Betaproteobacteria	J	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs	truA	-	5.4.99.12	ko:K06173	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PseudoU_synth_1
HKD3_k127_6332221_28	1163617.SCD_n00880	1.519e-65	232.0	COG0135@1|root,COG0135@2|Bacteria,1RA87@1224|Proteobacteria,2VPZV@28216|Betaproteobacteria	28216|Betaproteobacteria	E	Belongs to the TrpF family	trpF	-	5.3.1.24	ko:K01817	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03509	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	PRAI
HKD3_k127_6332221_4	85643.Tmz1t_3062	1.306e-228	713.0	COG0133@1|root,COG0133@2|Bacteria,1MUS8@1224|Proteobacteria,2VHV3@28216|Betaproteobacteria,2KUYW@206389|Rhodocyclales	206389|Rhodocyclales	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB	-	4.2.1.20	ko:K01696	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HKD3_k127_6332221_17	257310.BB3773	2.281e-97	344.0	COG0159@1|root,COG0159@2|Bacteria,1MXJV@1224|Proteobacteria,2VI78@28216|Betaproteobacteria,3T1U1@506|Alcaligenaceae	28216|Betaproteobacteria	E	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate	trpA	-	4.2.1.20	ko:K01695	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_syntA
HKD3_k127_6332221_11	999541.bgla_2g18100	2.349e-142	456.0	COG0777@1|root,COG0777@2|Bacteria,1MW8G@1224|Proteobacteria,2VHEQ@28216|Betaproteobacteria,1K1C4@119060|Burkholderiaceae	28216|Betaproteobacteria	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA	accD	-	2.1.3.15,6.4.1.2	ko:K01963	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
HKD3_k127_6332221_12	477184.KYC_25273	1.908e-132	436.0	COG0285@1|root,COG0285@2|Bacteria,1MVCH@1224|Proteobacteria,2VI0H@28216|Betaproteobacteria,3T1IK@506|Alcaligenaceae	28216|Betaproteobacteria	H	Belongs to the folylpolyglutamate synthase family	folC	-	6.3.2.12,6.3.2.17	ko:K11754	ko00790,ko01100,map00790,map01100	M00126,M00841	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	Mur_ligase_C,Mur_ligase_M
HKD3_k127_6332221_43	1265502.KB905929_gene2277	9.546e-17	91.0	COG3147@1|root,COG3147@2|Bacteria,1R7IV@1224|Proteobacteria,2VPE1@28216|Betaproteobacteria,4AC9S@80864|Comamonadaceae	28216|Betaproteobacteria	D	PFAM Sporulation domain protein	dedD	-	-	ko:K03749	-	-	-	-	ko00000	-	-	-	SPOR
HKD3_k127_6332221_40	1288494.EBAPG3_25370	3.843e-28	121.0	COG1286@1|root,COG1286@2|Bacteria,1NF4G@1224|Proteobacteria,2VUM6@28216|Betaproteobacteria,3739Y@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Colicin V production	cvpA	-	-	ko:K03558	-	-	-	-	ko00000	-	-	-	Colicin_V
HKD3_k127_6332221_3	640081.Dsui_3186	8.947e-229	717.0	COG0034@1|root,COG0034@2|Bacteria,1MU0V@1224|Proteobacteria,2VJM1@28216|Betaproteobacteria,2KUPY@206389|Rhodocyclales	206389|Rhodocyclales	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	-	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_6,Pribosyltran
HKD3_k127_6332221_7	1175306.GWL_26740	3.081e-182	580.0	COG2873@1|root,COG2873@2|Bacteria,1NQME@1224|Proteobacteria,2VI2K@28216|Betaproteobacteria,47398@75682|Oxalobacteraceae	28216|Betaproteobacteria	E	Cys/Met metabolism PLP-dependent enzyme	mdeA_1	-	2.5.1.48,2.5.1.49	ko:K01739,ko:K01740	ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017	R00999,R01287,R01288,R02508,R03217,R03260,R04859,R04944,R04945,R04946	RC00020,RC00056,RC00069,RC00420,RC02821,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000	-	-	-	Cys_Met_Meta_PP
HKD3_k127_6332221_31	1205680.CAKO01000041_gene5520	3.855e-62	227.0	COG0861@1|root,COG0861@2|Bacteria,1QZU6@1224|Proteobacteria,2TURK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Integral membrane protein TerC	-	-	-	-	-	-	-	-	-	-	-	-	TerC
HKD3_k127_6332221_30	314278.NB231_05045	2.914e-64	229.0	COG2908@1|root,COG2908@2|Bacteria,1N3U7@1224|Proteobacteria,1RP1X@1236|Gammaproteobacteria,1WX0F@135613|Chromatiales	135613|Chromatiales	S	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxH	-	3.6.1.54	ko:K03269	ko00540,ko01100,map00540,map01100	M00060	R04549	RC00002	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Metallophos,Metallophos_2
HKD3_k127_6332221_24	1133849.O3I_000765	2.169e-75	256.0	COG0652@1|root,COG0652@2|Bacteria,2IGYX@201174|Actinobacteria,4FXVU@85025|Nocardiaceae	201174|Actinobacteria	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	-	-	5.2.1.8	ko:K03768	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Pro_isomerase
HKD3_k127_6332221_34	323848.Nmul_A1884	1.641e-55	201.0	COG0652@1|root,COG0652@2|Bacteria,1R9ZQ@1224|Proteobacteria,2VQ3Z@28216|Betaproteobacteria,3731S@32003|Nitrosomonadales	28216|Betaproteobacteria	M	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	ppiA	-	5.2.1.8	ko:K01802,ko:K03767,ko:K03768	ko01503,ko04217,map01503,map04217	-	-	-	ko00000,ko00001,ko01000,ko03110,ko04147	-	-	-	Pro_isomerase
HKD3_k127_6332221_37	398578.Daci_2506	2.399e-29	135.0	COG0457@1|root,COG0457@2|Bacteria,1Q84V@1224|Proteobacteria,2VJAQ@28216|Betaproteobacteria,4AB2J@80864|Comamonadaceae	28216|Betaproteobacteria	NU	PFAM TPR repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440,TPR_11,TPR_16,TPR_17,TPR_19,TPR_8
HKD3_k127_6332221_35	1123368.AUIS01000009_gene2433	8.88e-46	169.0	COG3439@1|root,COG3439@2|Bacteria,1RH9Z@1224|Proteobacteria,1T9P7@1236|Gammaproteobacteria,2NDUI@225057|Acidithiobacillales	225057|Acidithiobacillales	S	Domain of unknown function DUF302	-	-	-	-	-	-	-	-	-	-	-	-	DUF302
HKD3_k127_6332221_36	1123487.KB892835_gene3590	3.076e-33	144.0	COG0824@1|root,COG0824@2|Bacteria,1RI3X@1224|Proteobacteria,2VX1P@28216|Betaproteobacteria,2KZ3V@206389|Rhodocyclales	206389|Rhodocyclales	S	Acyl-ACP thioesterase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-ACP_TE
HKD3_k127_6332221_25	1121920.AUAU01000018_gene1774	4.909e-75	270.0	COG2162@1|root,COG2162@2|Bacteria	2|Bacteria	Q	arylamine N-acetyltransferase activity	nat	-	2.3.1.118	ko:K00675	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_2
HKD3_k127_6332221_22	748247.AZKH_2167	5.104e-83	285.0	COG2816@1|root,COG2816@2|Bacteria,1QGCX@1224|Proteobacteria,2VQIR@28216|Betaproteobacteria,2KW28@206389|Rhodocyclales	206389|Rhodocyclales	L	NADH pyrophosphatase-like rudimentary NUDIX domain	-	-	3.6.1.22	ko:K03426	ko00760,ko01100,ko04146,map00760,map01100,map04146	-	R00103,R03004,R11104	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX,NUDIX-like,zf-NADH-PPase
HKD3_k127_6332221_0	748247.AZKH_3902	1.637e-307	967.0	COG1529@1|root,COG1529@2|Bacteria,1QTTJ@1224|Proteobacteria,2VHB9@28216|Betaproteobacteria,2KVA6@206389|Rhodocyclales	206389|Rhodocyclales	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	1.3.99.16	ko:K07303	-	-	-	-	ko00000,ko01000	-	-	-	Ald_Xan_dh_C2
HKD3_k127_6332221_33	1000565.METUNv1_03498	8.512e-59	207.0	COG2080@1|root,COG2080@2|Bacteria,1RD8C@1224|Proteobacteria,2VQ9M@28216|Betaproteobacteria,2KWI4@206389|Rhodocyclales	206389|Rhodocyclales	C	[2Fe-2S] binding domain	-	-	1.3.99.16	ko:K07302	-	-	-	-	ko00000,ko01000	-	-	-	Fer2,Fer2_2
HKD3_k127_6332221_9	522306.CAP2UW1_1030	1.474e-177	561.0	COG1186@1|root,COG1186@2|Bacteria,1MUAW@1224|Proteobacteria,2VJ6C@28216|Betaproteobacteria,1KPV3@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	J	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA	prfB	-	-	ko:K02836	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
HKD3_k127_6332221_38	1101192.KB910516_gene1126	3.67e-29	124.0	COG5135@1|root,COG5135@2|Bacteria,1QVB4@1224|Proteobacteria,2TYMC@28211|Alphaproteobacteria,1JZJ6@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	Pyridoxamine 5'-phosphate oxidase	-	-	1.4.3.5	ko:K00275	ko00750,ko01100,ko01120,map00750,map01100,map01120	M00124	R00277,R00278,R01710,R01711	RC00048,RC00116	ko00000,ko00001,ko00002,ko01000	-	-	-	Putative_PNPOx
HKD3_k127_6332221_44	477184.KYC_04467	1.888e-11	74.0	COG1190@1|root,COG1190@2|Bacteria,1MX1V@1224|Proteobacteria,2VH1A@28216|Betaproteobacteria,3T2GE@506|Alcaligenaceae	28216|Betaproteobacteria	J	Belongs to the class-II aminoacyl-tRNA synthetase family	lysS	-	6.1.1.6	ko:K04567	ko00970,map00970	M00359,M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
HKD3_k127_6339270_1	1123368.AUIS01000031_gene1420	6.305e-156	509.0	COG0659@1|root,COG0659@2|Bacteria,1MWDF@1224|Proteobacteria,1SYC8@1236|Gammaproteobacteria,2NE68@225057|Acidithiobacillales	225057|Acidithiobacillales	P	STAS domain	-	-	-	ko:K03321	-	-	-	-	ko00000,ko02000	2.A.53.3	-	-	STAS,Sulfate_transp
HKD3_k127_6339270_0	572477.Alvin_2061	0.0	1317.0	COG1982@1|root,COG1982@2|Bacteria,1MWK4@1224|Proteobacteria,1RMVF@1236|Gammaproteobacteria,1WXY3@135613|Chromatiales	135613|Chromatiales	E	PFAM Orn Lys Arg decarboxylase	-	-	4.1.1.19	ko:K01584	ko00330,ko01100,map00330,map01100	M00133	R00566	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	OKR_DC_1,OKR_DC_1_C,OKR_DC_1_N
HKD3_k127_6339270_4	267608.RSp0711	8.846e-80	274.0	COG5486@1|root,COG5486@2|Bacteria,1R6FN@1224|Proteobacteria,2VMCU@28216|Betaproteobacteria,1K22S@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Predicted metal-binding integral membrane protein (DUF2182)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2182
HKD3_k127_6339270_3	296591.Bpro_1658	1.536e-85	288.0	COG5588@1|root,COG5588@2|Bacteria,1MWK3@1224|Proteobacteria,2VMAI@28216|Betaproteobacteria,4AHFW@80864|Comamonadaceae	28216|Betaproteobacteria	S	Protein of unknown function (DUF1326)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1326
HKD3_k127_6339270_2	1380391.JIAS01000012_gene3935	1.157e-125	411.0	COG2223@1|root,COG2223@2|Bacteria,1QVKP@1224|Proteobacteria,2TRVV@28211|Alphaproteobacteria,2JRW4@204441|Rhodospirillales	204441|Rhodospirillales	P	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD3_k127_6346062_9	522306.CAP2UW1_2752	1.057e-65	231.0	COG0663@1|root,COG0663@2|Bacteria,1MVUI@1224|Proteobacteria,2VH4Y@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Phenylacetic acid degradation protein PaaY	paaY	-	-	ko:K02617,ko:K08279	-	-	-	-	ko00000	-	-	-	Hexapep
HKD3_k127_6346062_0	265072.Mfla_0887	0.0	1675.0	COG0046@1|root,COG0047@1|root,COG0046@2|Bacteria,COG0047@2|Bacteria,1MYN4@1224|Proteobacteria,2VHTE@28216|Betaproteobacteria,2KKQX@206350|Nitrosomonadales	206350|Nitrosomonadales	F	Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS_C,GATase_5
HKD3_k127_6346062_1	762966.HMPREF9439_00396	1.549e-163	521.0	COG0516@1|root,COG0516@2|Bacteria,1MUJM@1224|Proteobacteria,2VJMM@28216|Betaproteobacteria,4PQBE@995019|Sutterellaceae	28216|Betaproteobacteria	F	Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides	guaC	-	1.7.1.7	ko:K00364	ko00230,map00230	-	R01134	RC00457	ko00000,ko00001,ko01000	-	-	-	IMPDH
HKD3_k127_6346062_8	1117318.PRUB_05556	1.897e-74	287.0	COG0288@1|root,COG0288@2|Bacteria,1NGFN@1224|Proteobacteria,1RSY6@1236|Gammaproteobacteria,2Q1PN@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	P	Reversible hydration of carbon dioxide	can	GO:0003674,GO:0003824,GO:0004089,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008270,GO:0015976,GO:0016829,GO:0016835,GO:0016836,GO:0043167,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914	4.2.1.1	ko:K01673	ko00910,map00910	-	R00132,R10092	RC02807	ko00000,ko00001,ko01000	-	-	iSBO_1134.SBO_0115,iSbBS512_1146.SbBS512_E0119	Pro_CA
HKD3_k127_6346062_3	62928.azo0439	1.064e-131	422.0	COG1126@1|root,COG1126@2|Bacteria,1MU9Q@1224|Proteobacteria,2VHIC@28216|Betaproteobacteria,2KUY5@206389|Rhodocyclales	206389|Rhodocyclales	E	ABC-type polar amino acid transport system, ATPase component	-	-	-	ko:K10004	ko02010,ko02020,map02010,map02020	M00230	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.3.19,3.A.1.3.4	-	-	ABC_tran
HKD3_k127_6346062_6	1095769.CAHF01000001_gene3551	1.482e-94	315.0	COG0765@1|root,COG0765@2|Bacteria,1MV3I@1224|Proteobacteria,2VIQB@28216|Betaproteobacteria,472AN@75682|Oxalobacteraceae	28216|Betaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	gltK	-	-	ko:K10002	ko02010,ko02020,map02010,map02020	M00230	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3.19,3.A.1.3.4	-	-	BPD_transp_1
HKD3_k127_6346062_5	375286.mma_0280	1.226e-94	316.0	COG0765@1|root,COG0765@2|Bacteria,1MUVX@1224|Proteobacteria,2VJ8A@28216|Betaproteobacteria,472RX@75682|Oxalobacteraceae	28216|Betaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	gltJ	-	-	ko:K02029,ko:K10003	ko02010,ko02020,map02010,map02020	M00230,M00236	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3,3.A.1.3.19,3.A.1.3.4	-	-	BPD_transp_1
HKD3_k127_6346062_2	204773.HEAR0225	7.873e-133	454.0	COG0834@1|root,COG0834@2|Bacteria,1MV5D@1224|Proteobacteria,2VHFS@28216|Betaproteobacteria,4737I@75682|Oxalobacteraceae	28216|Betaproteobacteria	ET	Bacterial periplasmic substrate-binding proteins	gltI	-	-	ko:K10001	ko02010,ko02020,map02010,map02020	M00230	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3.19,3.A.1.3.4	-	-	SBP_bac_3
HKD3_k127_6346062_4	85643.Tmz1t_2570	3.697e-112	380.0	COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,1MU1Q@1224|Proteobacteria,2VJZD@28216|Betaproteobacteria,2KU9G@206389|Rhodocyclales	206389|Rhodocyclales	H	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	-	-	-	-	-	-	-	-	-	-	-	Carb_kinase,YjeF_N
HKD3_k127_6346062_7	375286.mma_0551	2.049e-94	313.0	COG0604@1|root,COG0604@2|Bacteria,1MWBD@1224|Proteobacteria,2VH3Z@28216|Betaproteobacteria,472IJ@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	NADPH quinone	qor	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
HKD3_k127_6394010_3	1300345.LF41_1446	8.12e-85	306.0	COG1075@1|root,COG1075@2|Bacteria	2|Bacteria	KLT	acetyltransferases and hydrolases with the alpha beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	DUF900,PGAP1,Peptidase_C14
HKD3_k127_6394010_1	1097668.BYI23_B013350	2.221e-141	454.0	COG0500@1|root,COG2226@2|Bacteria,1MXP4@1224|Proteobacteria,2VJM3@28216|Betaproteobacteria,1K5G7@119060|Burkholderiaceae	28216|Betaproteobacteria	Q	Methionine biosynthesis protein MetW	ubiE_1	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
HKD3_k127_6394010_2	1097668.BYI23_B013360	1.114e-123	409.0	COG2207@1|root,COG2207@2|Bacteria,1N0FA@1224|Proteobacteria,2VKR0@28216|Betaproteobacteria,1K2I8@119060|Burkholderiaceae	28216|Betaproteobacteria	K	Cupin	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_6,HTH_18
HKD3_k127_6394010_0	1121939.L861_00430	4.791e-203	646.0	COG0277@1|root,COG0277@2|Bacteria,1MUPW@1224|Proteobacteria,1RRDD@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	FAD linked oxidase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	BBE,FAD_binding_4
HKD3_k127_6447498_3	94624.Bpet3414	2.921e-130	421.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2VIF8@28216|Betaproteobacteria,3T30A@506|Alcaligenaceae	28216|Betaproteobacteria	I	Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation	fadA	-	2.3.1.16	ko:K00632	ko00071,ko00280,ko00281,ko00362,ko00592,ko00642,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00362,map00592,map00642,map01100,map01110,map01120,map01130,map01212	M00087,M00113	R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000	-	-	-	Thiolase_C,Thiolase_N
HKD3_k127_6447498_13	762376.AXYL_04503	2.056e-35	142.0	COG0810@1|root,COG0810@2|Bacteria,1MZQW@1224|Proteobacteria,2VU0N@28216|Betaproteobacteria,3T4FY@506|Alcaligenaceae	28216|Betaproteobacteria	M	Chalcone isomerase-like	-	-	-	-	-	-	-	-	-	-	-	-	Chalcone_3
HKD3_k127_6447498_2	365046.Rta_02380	4.934e-137	445.0	2C7F6@1|root,2Z8AK@2|Bacteria,1PEE5@1224|Proteobacteria,2VKQ6@28216|Betaproteobacteria,4ABA6@80864|Comamonadaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_6447498_16	1449049.JONW01000011_gene2311	7.829e-17	94.0	2E902@1|root,3339H@2|Bacteria,1N9U6@1224|Proteobacteria,2UFG4@28211|Alphaproteobacteria,2KH8D@204458|Caulobacterales	204458|Caulobacterales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_6447498_14	1123368.AUIS01000003_gene1841	1.57e-30	124.0	COG4783@1|root,COG4783@2|Bacteria,1N76P@1224|Proteobacteria,1T4CE@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16
HKD3_k127_6447498_10	1120999.JONM01000023_gene3147	5.498e-66	230.0	COG0328@1|root,COG0328@2|Bacteria,1RCZ1@1224|Proteobacteria,2VR4W@28216|Betaproteobacteria,2KR3R@206351|Neisseriales	206351|Neisseriales	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhA	-	3.1.26.4	ko:K03469	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_H
HKD3_k127_6447498_8	292415.Tbd_1664	1.112e-74	259.0	COG0500@1|root,COG2226@2|Bacteria,1QTWC@1224|Proteobacteria,2VQ89@28216|Betaproteobacteria,1KRS7@119069|Hydrogenophilales	119069|Hydrogenophilales	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
HKD3_k127_6447498_6	123899.JPQP01000019_gene2726	8.042e-93	312.0	COG0491@1|root,COG0491@2|Bacteria,1MU8Q@1224|Proteobacteria,2VGZG@28216|Betaproteobacteria,3T1K5@506|Alcaligenaceae	28216|Betaproteobacteria	S	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid	gloB	-	3.1.2.6	ko:K01069	ko00620,map00620	-	R01736	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	HAGH_C,Lactamase_B
HKD3_k127_6447498_4	640081.Dsui_2797	6.264e-124	425.0	COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,1MWKE@1224|Proteobacteria,2VIR7@28216|Betaproteobacteria,2KUQ6@206389|Rhodocyclales	206389|Rhodocyclales	M	COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains)	-	-	-	ko:K08307	-	-	-	-	ko00000,ko01000,ko01011	-	-	-	LysM,SLT
HKD3_k127_6447498_1	1123392.AQWL01000002_gene1982	4.771e-157	519.0	COG0019@1|root,COG0019@2|Bacteria,1MUA6@1224|Proteobacteria,2VI3M@28216|Betaproteobacteria,1KRG7@119069|Hydrogenophilales	119069|Hydrogenophilales	E	Pyridoxal-dependent decarboxylase, pyridoxal binding domain	-	-	4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
HKD3_k127_6447498_15	1123392.AQWL01000002_gene1983	1.692e-25	109.0	COG1965@1|root,COG1965@2|Bacteria,1RH9A@1224|Proteobacteria,2VVS3@28216|Betaproteobacteria,1KT80@119069|Hydrogenophilales	119069|Hydrogenophilales	P	Frataxin-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Frataxin_Cyay
HKD3_k127_6447498_12	999541.bgla_1g34140	3.013e-48	183.0	COG1451@1|root,COG1451@2|Bacteria,1MXZU@1224|Proteobacteria,2VNC5@28216|Betaproteobacteria,1K1N3@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Metal-dependent hydrolase	-	-	-	ko:K07043	-	-	-	-	ko00000	-	-	-	DUF45
HKD3_k127_6447498_9	261292.Nit79A3_3443	1.694e-73	254.0	COG0204@1|root,COG0204@2|Bacteria,1MY51@1224|Proteobacteria,2VNAX@28216|Betaproteobacteria,372BP@32003|Nitrosomonadales	28216|Betaproteobacteria	I	PFAM Phospholipid glycerol acyltransferase	nlaB	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
HKD3_k127_6447498_7	1163617.SCD_n02567	3.924e-83	280.0	COG0241@1|root,COG0241@2|Bacteria,1RDGR@1224|Proteobacteria,2VQ49@28216|Betaproteobacteria	28216|Betaproteobacteria	E	D,D-heptose 1,7-bisphosphate phosphatase	gmhB	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008270,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0034200,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914	3.1.3.82,3.1.3.83	ko:K03273	ko00540,ko01100,map00540,map01100	M00064	R05647,R09771	RC00017	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hydrolase,Hydrolase_like,PNK3P
HKD3_k127_6447498_0	859657.RPSI07_2840	1.691e-221	718.0	COG0751@1|root,COG0751@2|Bacteria,1MV2F@1224|Proteobacteria,2VICG@28216|Betaproteobacteria,1K0KS@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Glycyl-tRNA synthetase beta subunit	glyS	-	6.1.1.14	ko:K01879	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_1,tRNA_synt_2f
HKD3_k127_6447498_5	1144319.PMI16_00757	4.685e-112	364.0	COG0752@1|root,COG0752@2|Bacteria,1MVCJ@1224|Proteobacteria,2VIQX@28216|Betaproteobacteria,4735F@75682|Oxalobacteraceae	28216|Betaproteobacteria	J	Glycyl-tRNA synthetase, alpha subunit	glyQ	-	6.1.1.14	ko:K01878	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2e
HKD3_k127_6537747_3	497321.C664_11580	3.044e-58	204.0	COG3384@1|root,COG3384@2|Bacteria,1MW77@1224|Proteobacteria,2VN0D@28216|Betaproteobacteria,2KXGN@206389|Rhodocyclales	206389|Rhodocyclales	C	Catalytic LigB subunit of aromatic ring-opening dioxygenase	-	-	1.13.11.8	ko:K04101	ko00362,ko00624,ko00627,ko01120,map00362,map00624,map00627,map01120	-	R01632,R03550,R04280,R09565	RC00233,RC00387,RC00535,RC02567,RC02694	br01602,ko00000,ko00001,ko01000	-	-	-	LigB
HKD3_k127_6537747_5	62928.azo2523	2.377e-44	178.0	COG3384@1|root,COG3384@2|Bacteria,1RIBC@1224|Proteobacteria,2VSU2@28216|Betaproteobacteria,2KYSN@206389|Rhodocyclales	206389|Rhodocyclales	S	Aromatic-ring-opening dioxygenase LigAB, LigA subunit	-	-	1.13.11.8	ko:K04100	ko00362,ko00624,ko00627,ko01120,map00362,map00624,map00627,map01120	-	R01632,R03550,R04280,R09565	RC00233,RC00387,RC00535,RC02567,RC02694	br01602,ko00000,ko00001,ko01000	-	-	-	LigA
HKD3_k127_6537747_1	1123367.C666_09805	5.455e-154	494.0	COG0673@1|root,COG0673@2|Bacteria,1MXUP@1224|Proteobacteria,2VIRJ@28216|Betaproteobacteria	28216|Betaproteobacteria	E	oxidoreductase	ligC	-	1.1.1.312	ko:K10219	ko00350,ko00362,ko00627,ko01120,ko01220,map00350,map00362,map00627,map01120,map01220	M00533	R04278,R04279,R04418,R04419	RC00251,RC00254	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_zinc_N,GFO_IDH_MocA
HKD3_k127_6537747_0	365044.Pnap_1901	2.457e-225	702.0	COG0654@1|root,COG0654@2|Bacteria,1MV8T@1224|Proteobacteria,2VIVU@28216|Betaproteobacteria,4A9N6@80864|Comamonadaceae	28216|Betaproteobacteria	CH	4-hydroxybenzoate 3-monooxygenase	pobA	-	1.14.13.2	ko:K00481	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	-	R01298	RC00046	ko00000,ko00001,ko01000	-	-	-	FAD_binding_3
HKD3_k127_6537747_2	1449076.JOOE01000002_gene754	1.614e-140	451.0	COG3384@1|root,COG3384@2|Bacteria,1MW77@1224|Proteobacteria,2TRP1@28211|Alphaproteobacteria,2K02T@204457|Sphingomonadales	204457|Sphingomonadales	S	Extradiol catechol dioxygenase that catalyzes the oxidative cleavage of substituted catechols	-	-	1.13.11.8	ko:K04101	ko00362,ko00624,ko00627,ko01120,map00362,map00624,map00627,map01120	-	R01632,R03550,R04280,R09565	RC00233,RC00387,RC00535,RC02567,RC02694	br01602,ko00000,ko00001,ko01000	-	-	-	LigB
HKD3_k127_6537747_4	1437824.BN940_08551	7.794e-50	180.0	COG3384@1|root,COG3384@2|Bacteria,1RA8A@1224|Proteobacteria,2VQ2B@28216|Betaproteobacteria,3T7IJ@506|Alcaligenaceae	28216|Betaproteobacteria	S	Aromatic-ring-opening dioxygenase LigAB, LigA subunit	-	-	1.13.11.8	ko:K04100	ko00362,ko00624,ko00627,ko01120,map00362,map00624,map00627,map01120	-	R01632,R03550,R04280,R09565	RC00233,RC00387,RC00535,RC02567,RC02694	br01602,ko00000,ko00001,ko01000	-	-	-	LigA
HKD3_k127_6537747_6	1442599.JAAN01000005_gene980	3.772e-13	68.0	COG3618@1|root,COG3618@2|Bacteria,1N2QM@1224|Proteobacteria,1RQ8V@1236|Gammaproteobacteria,1X6AE@135614|Xanthomonadales	135614|Xanthomonadales	S	Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
HKD3_k127_6563470_6	1268622.AVS7_04198	1.352e-27	128.0	2BKYI@1|root,32FF5@2|Bacteria,1RB6X@1224|Proteobacteria,2WE8M@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter TctB family	-	-	-	-	-	-	-	-	-	-	-	-	TctB
HKD3_k127_6563470_2	1095769.CAHF01000015_gene2818	2.868e-142	480.0	COG3181@1|root,COG3181@2|Bacteria,1MXEX@1224|Proteobacteria,2VKSV@28216|Betaproteobacteria	1224|Proteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HKD3_k127_6563470_1	1095769.CAHF01000015_gene2817	4.97e-169	548.0	COG4091@1|root,COG4091@2|Bacteria,1MUZX@1224|Proteobacteria,2VI2Z@28216|Betaproteobacteria	28216|Betaproteobacteria	E	homoserine dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,NAD_binding_3,SAF
HKD3_k127_6563470_4	1095769.CAHF01000015_gene2824	1.631e-67	242.0	COG0583@1|root,COG0583@2|Bacteria,1Q6E2@1224|Proteobacteria,2VMC3@28216|Betaproteobacteria,4729V@75682|Oxalobacteraceae	28216|Betaproteobacteria	K	Bacterial regulatory helix-turn-helix protein, lysR family	gbpR	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HKD3_k127_6563470_0	1485544.JQKP01000004_gene505	7.195e-218	681.0	COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,2VI9I@28216|Betaproteobacteria,44V4J@713636|Nitrosomonadales	28216|Betaproteobacteria	P	Ammonium Transporter Family	-	-	-	ko:K03320,ko:K06580	-	-	-	-	ko00000,ko02000,ko04090	1.A.11,1.A.11.4	-	-	Ammonium_transp
HKD3_k127_6563470_5	679197.HMPREF9336_02699	8.924e-63	233.0	COG2017@1|root,COG2017@2|Bacteria	2|Bacteria	G	converts alpha-aldose to the beta-anomer	-	-	5.1.3.3	ko:K01785	ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130	M00632	R01602,R10619	RC00563	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldose_epim
HKD3_k127_6563470_3	1121004.ATVC01000045_gene848	2.548e-139	455.0	COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,2VIA1@28216|Betaproteobacteria,2KQ2R@206351|Neisseriales	206351|Neisseriales	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	spoT	-	2.7.6.5,3.1.7.2	ko:K01139	ko00230,map00230	-	R00336,R00429	RC00002,RC00078	ko00000,ko00001,ko01000,ko03009	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
HKD3_k127_659668_7	488538.SAR116_0921	4.375e-65	228.0	COG1028@1|root,COG1028@2|Bacteria	488538.SAR116_0921|-	IQ	oxidoreductase activity, acting on CH-OH group of donors	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	-
HKD3_k127_659668_3	1187851.A33M_2617	2.277e-89	312.0	COG0169@1|root,COG0169@2|Bacteria,1MVH4@1224|Proteobacteria,2TS99@28211|Alphaproteobacteria,3FD0F@34008|Rhodovulum	28211|Alphaproteobacteria	E	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)	aroE	-	1.1.1.25	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413	RC00206	ko00000,ko00001,ko00002,ko01000	-	-	-	Shikimate_DH,Shikimate_dh_N
HKD3_k127_659668_4	331869.BAL199_08288	2.355e-83	299.0	COG1082@1|root,COG1082@2|Bacteria,1Q173@1224|Proteobacteria,2TTFM@28211|Alphaproteobacteria,4BQK3@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
HKD3_k127_659668_2	1071679.BG57_14510	8.158e-100	331.0	COG1028@1|root,COG1028@2|Bacteria,1MU2T@1224|Proteobacteria,2VN5A@28216|Betaproteobacteria,1K6M7@119060|Burkholderiaceae	28216|Betaproteobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HKD3_k127_659668_5	1121372.AULK01000014_gene1807	1.02e-81	283.0	COG0673@1|root,COG0673@2|Bacteria,2GJCY@201174|Actinobacteria,4FM2G@85023|Microbacteriaceae	201174|Actinobacteria	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	1.1.1.18,1.1.1.369	ko:K00010	ko00521,ko00562,ko01100,ko01120,ko01130,map00521,map00562,map01100,map01120,map01130	-	R01183,R09951	RC00182	ko00000,ko00001,ko01000	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
HKD3_k127_659668_8	1125973.JNLC01000012_gene1029	6.103e-65	231.0	COG1028@1|root,COG1028@2|Bacteria,1R6D6@1224|Proteobacteria,2U672@28211|Alphaproteobacteria,3JZB6@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HKD3_k127_659668_0	748247.AZKH_p0529	3.246e-223	731.0	COG4670@1|root,COG4670@2|Bacteria,1MUJW@1224|Proteobacteria,2VH8B@28216|Betaproteobacteria,2KVP5@206389|Rhodocyclales	28216|Betaproteobacteria	I	CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons	-	-	-	-	-	-	-	-	-	-	-	-	CoA_trans
HKD3_k127_659668_1	748247.AZKH_p0530	9.935e-172	547.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2VN2C@28216|Betaproteobacteria	28216|Betaproteobacteria	C	PFAM acyl-CoA dehydrogenase domain protein	-	-	1.3.8.3,1.3.8.7	ko:K00249,ko:K07545	ko00071,ko00280,ko00410,ko00623,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko01220,ko03320,map00071,map00280,map00410,map00623,map00640,map01100,map01110,map01120,map01130,map01200,map01212,map01220,map03320	M00013,M00036,M00087,M00418	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754,R05584	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246,RC02037	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HKD3_k127_659668_6	237609.PSAKL28_46490	3.837e-65	228.0	COG1414@1|root,COG1414@2|Bacteria,1MUNW@1224|Proteobacteria,1RRQD@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_IclR,IclR
HKD3_k127_6615596_6	1297865.APJD01000014_gene958	1.071e-29	129.0	COG3038@1|root,COG3038@2|Bacteria,1MZ7X@1224|Proteobacteria,2UBYU@28211|Alphaproteobacteria,3JU04@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Prokaryotic cytochrome b561	-	-	-	ko:K12262	-	-	-	-	ko00000	-	-	-	Ni_hydr_CYTB
HKD3_k127_6615596_9	497321.C664_16505	1.312e-06	62.0	2ECPV@1|root,336MK@2|Bacteria,1NC90@1224|Proteobacteria,2VWA4@28216|Betaproteobacteria,2KXBP@206389|Rhodocyclales	206389|Rhodocyclales	S	FeoA	-	-	-	-	-	-	-	-	-	-	-	-	FeoA
HKD3_k127_6615596_0	85643.Tmz1t_3531	2.729e-248	786.0	COG0370@1|root,COG0370@2|Bacteria,1MUZC@1224|Proteobacteria,2VIRG@28216|Betaproteobacteria,2KVZR@206389|Rhodocyclales	206389|Rhodocyclales	P	transporter of a GTP-driven Fe(2 ) uptake system	-	-	-	ko:K04759	-	-	-	-	ko00000,ko02000	9.A.8.1	-	-	FeoB_C,FeoB_N,Gate
HKD3_k127_6615596_7	383372.Rcas_1524	2.618e-27	116.0	COG0517@1|root,COG0517@2|Bacteria,2G6TI@200795|Chloroflexi,376YQ@32061|Chloroflexia	32061|Chloroflexia	S	amino acid-binding ACT domain protein	-	-	-	ko:K04767	-	-	-	-	ko00000	-	-	-	CBS
HKD3_k127_6615596_3	1380394.JADL01000006_gene5309	9.201e-98	342.0	COG0265@1|root,COG0265@2|Bacteria,1MURF@1224|Proteobacteria,2TUVW@28211|Alphaproteobacteria,2JRVV@204441|Rhodospirillales	204441|Rhodospirillales	O	Domain present in PSD-95, Dlg, and ZO-1/2.	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
HKD3_k127_6615596_1	977880.RALTA_B1328	1.288e-213	688.0	COG3119@1|root,COG3119@2|Bacteria,1MV0B@1224|Proteobacteria,2VNBG@28216|Betaproteobacteria,1KGHC@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
HKD3_k127_6615596_2	391735.Veis_3562	8.801e-111	374.0	COG1126@1|root,COG1126@2|Bacteria,1MU9Q@1224|Proteobacteria,2VHIC@28216|Betaproteobacteria,4AB90@80864|Comamonadaceae	28216|Betaproteobacteria	E	PFAM ABC transporter related	-	-	3.6.3.21	ko:K02028	-	M00236	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.3	-	-	ABC_tran
HKD3_k127_6615596_5	391735.Veis_3563	2.725e-85	288.0	COG0765@1|root,COG0765@2|Bacteria,1R8X2@1224|Proteobacteria,2WEZK@28216|Betaproteobacteria,4AHCV@80864|Comamonadaceae	28216|Betaproteobacteria	P	TIGRFAM polar amino acid ABC transporter, inner membrane subunit	-	-	-	ko:K02029	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	BPD_transp_1
HKD3_k127_6615596_4	391735.Veis_3564	2.956e-90	302.0	COG0765@1|root,COG0765@2|Bacteria,1R90A@1224|Proteobacteria,2W0IR@28216|Betaproteobacteria,4AGSW@80864|Comamonadaceae	28216|Betaproteobacteria	P	TIGRFAM polar amino acid ABC transporter, inner membrane subunit	-	-	-	ko:K02029	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	BPD_transp_1
HKD3_k127_6615596_8	1122604.JONR01000006_gene2513	5.779e-14	75.0	COG0454@1|root,COG0456@2|Bacteria,1NCMN@1224|Proteobacteria,1SFS0@1236|Gammaproteobacteria,1X7VK@135614|Xanthomonadales	135614|Xanthomonadales	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_10
HKD3_k127_6618138_9	1313421.JHBV01000038_gene2852	0.000946	44.0	COG1404@1|root,COG1520@1|root,COG3291@1|root,COG1404@2|Bacteria,COG1520@2|Bacteria,COG3291@2|Bacteria,4PMDA@976|Bacteroidetes	976|Bacteroidetes	O	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	MAM,PKD,Sortilin-Vps10
HKD3_k127_6618138_8	1297742.A176_02454	5.612e-06	60.0	COG1404@1|root,COG1404@2|Bacteria,1MU3S@1224|Proteobacteria,42Q14@68525|delta/epsilon subdivisions,2WJ8C@28221|Deltaproteobacteria,2YX9F@29|Myxococcales	28221|Deltaproteobacteria	O	Belongs to the peptidase S8 family	-	-	-	ko:K14645	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002,ko03110	-	-	-	Peptidase_S8
HKD3_k127_6618138_4	1218084.BBJK01000195_gene8088	8.117e-107	382.0	COG4409@1|root,COG4409@2|Bacteria,1Q513@1224|Proteobacteria,2WB3C@28216|Betaproteobacteria,1K536@119060|Burkholderiaceae	28216|Betaproteobacteria	G	BNR repeat-like domain	-	-	-	-	-	-	-	-	-	-	-	-	BNR,BNR_2
HKD3_k127_6618138_0	640081.Dsui_1637	3.476e-166	531.0	COG2070@1|root,COG2070@2|Bacteria,1N52W@1224|Proteobacteria,2VJ45@28216|Betaproteobacteria,2KVWV@206389|Rhodocyclales	206389|Rhodocyclales	S	2-nitropropane dioxygenase	-	-	1.13.12.16	ko:K00459	ko00910,map00910	-	R00025	RC02541,RC02759	ko00000,ko00001,ko01000	-	-	-	NMO
HKD3_k127_6618138_1	748247.AZKH_3236	7.858e-163	516.0	COG0078@1|root,COG0078@2|Bacteria,1MUFM@1224|Proteobacteria,2VIVG@28216|Betaproteobacteria,2KV71@206389|Rhodocyclales	206389|Rhodocyclales	E	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline	argF	-	2.1.3.3	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844	R01398	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
HKD3_k127_6618138_7	1192034.CAP_7792	1.753e-40	159.0	COG0346@1|root,COG0346@2|Bacteria,1RH79@1224|Proteobacteria,43ACF@68525|delta/epsilon subdivisions,2X5SA@28221|Deltaproteobacteria,2Z208@29|Myxococcales	28221|Deltaproteobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HKD3_k127_6618138_3	1095769.CAHF01000011_gene2435	1.689e-112	376.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VHK8@28216|Betaproteobacteria,4731A@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HKD3_k127_6618138_2	1121035.AUCH01000012_gene3013	2.916e-135	441.0	COG0466@1|root,COG0466@2|Bacteria,1MWQ9@1224|Proteobacteria,2VJKY@28216|Betaproteobacteria,2KV7N@206389|Rhodocyclales	206389|Rhodocyclales	O	ATPase family associated with various cellular activities (AAA)	-	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA
HKD3_k127_6618138_6	279714.FuraDRAFT_0774	3.118e-66	242.0	COG1666@1|root,COG1666@2|Bacteria,1RDTF@1224|Proteobacteria,2VPZU@28216|Betaproteobacteria,2KQYV@206351|Neisseriales	206351|Neisseriales	S	Belongs to the UPF0234 family	-	-	-	ko:K09767	-	-	-	-	ko00000	-	-	-	DUF520
HKD3_k127_6618138_5	1218074.BAXZ01000022_gene4201	2.548e-71	245.0	COG0247@1|root,COG0247@2|Bacteria,1RF02@1224|Proteobacteria,2VRBG@28216|Betaproteobacteria,1K5WP@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Protein of unknown function (DUF3501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3501
HKD3_k127_6654201_2	859657.RPSI07_mp0735	1.213e-169	553.0	COG0587@1|root,COG0587@2|Bacteria,1MUE4@1224|Proteobacteria,2VHCS@28216|Betaproteobacteria,1K1R9@119060|Burkholderiaceae	28216|Betaproteobacteria	L	DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase	dnaE2	-	2.7.7.7	ko:K14162	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
HKD3_k127_6654201_0	1128421.JAGA01000002_gene557	1.238e-251	787.0	COG2866@1|root,COG2866@2|Bacteria,2NPI7@2323|unclassified Bacteria	2|Bacteria	E	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M14
HKD3_k127_6654201_1	243233.MCA2512	3.579e-196	640.0	COG3511@1|root,COG3511@2|Bacteria,1MVNS@1224|Proteobacteria,1RZUB@1236|Gammaproteobacteria,1XDZS@135618|Methylococcales	135618|Methylococcales	M	Phosphoesterase family	-	-	-	-	-	-	-	-	-	-	-	-	Phosphoesterase
HKD3_k127_6654201_11	1336233.JAEH01000026_gene1013	3.25e-40	153.0	COG0346@1|root,COG0346@2|Bacteria,1N08M@1224|Proteobacteria,1SBEZ@1236|Gammaproteobacteria,2QC5U@267890|Shewanellaceae	1236|Gammaproteobacteria	E	COG0346 Lactoylglutathione lyase and related lyases	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HKD3_k127_6654201_4	1411123.JQNH01000001_gene2879	1.861e-125	415.0	COG0477@1|root,COG2814@2|Bacteria,1MXPM@1224|Proteobacteria,2TSB9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
HKD3_k127_6654201_3	1095769.CAHF01000009_gene1397	7.899e-155	501.0	COG2334@1|root,COG2334@2|Bacteria,1MU2Q@1224|Proteobacteria,2VI9A@28216|Betaproteobacteria,4730X@75682|Oxalobacteraceae	28216|Betaproteobacteria	F	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response	srkA	-	-	-	-	-	-	-	-	-	-	-	APH
HKD3_k127_6654201_5	95619.PM1_0213830	4.765e-111	374.0	COG0154@1|root,COG0154@2|Bacteria,1MWRI@1224|Proteobacteria,1RS2Z@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	Amidase	-	-	-	-	-	-	-	-	-	-	-	-	Amidase
HKD3_k127_6654201_13	266265.Bxe_C0368	1.304e-08	59.0	COG3043@1|root,COG3043@2|Bacteria,1RHGD@1224|Proteobacteria,2VTPE@28216|Betaproteobacteria,1KHG9@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Electron transfer subunit of the periplasmic nitrate reductase complex NapAB	napB	-	-	ko:K02568	ko00910,ko01120,map00910,map01120	M00529,M00530	R00798	RC02812	ko00000,ko00001,ko00002	-	-	-	NapB
HKD3_k127_6654201_6	76114.ebA3079	8.657e-90	313.0	COG0389@1|root,COG0389@2|Bacteria,1MU5X@1224|Proteobacteria,2VIKH@28216|Betaproteobacteria,2KV3B@206389|Rhodocyclales	206389|Rhodocyclales	L	DNA polymerase involved in DNA repair	-	-	-	ko:K14161	-	-	-	-	ko00000,ko03400	-	-	-	IMS
HKD3_k127_6654201_7	237609.PSAKL28_34860	4.736e-77	262.0	COG2318@1|root,COG2318@2|Bacteria,1RH1I@1224|Proteobacteria,1SQT3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Damage-inducible protein DinB	-	-	-	-	-	-	-	-	-	-	-	-	DinB
HKD3_k127_6654201_10	292415.Tbd_0830	4.542e-55	202.0	COG4544@1|root,COG4544@2|Bacteria,1MZQU@1224|Proteobacteria,2VUGI@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division	-	-	-	ko:K13053,ko:K14160	-	-	-	-	ko00000,ko03036,ko03400	-	-	-	SulA
HKD3_k127_6654201_9	404589.Anae109_1654	2.17e-58	212.0	COG2764@1|root,COG2764@2|Bacteria,1RF5T@1224|Proteobacteria,42SN0@68525|delta/epsilon subdivisions,2WPY6@28221|Deltaproteobacteria,2Z0UJ@29|Myxococcales	28221|Deltaproteobacteria	S	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	ko:K04750	-	-	-	-	ko00000	-	-	-	3-dmu-9_3-mt,Glyoxalase
HKD3_k127_6654201_12	1121015.N789_03265	1.411e-24	119.0	2CHW3@1|root,32S6N@2|Bacteria,1N0I3@1224|Proteobacteria,1SCE5@1236|Gammaproteobacteria,1XAE3@135614|Xanthomonadales	135614|Xanthomonadales	S	Pathogenicity locus	mcrB	-	-	-	-	-	-	-	-	-	-	-	Cdd1
HKD3_k127_6654201_8	932213.SPM24T3_19997	5.305e-71	247.0	COG1974@1|root,COG1974@2|Bacteria,1MW80@1224|Proteobacteria,1RMXF@1236|Gammaproteobacteria,400DF@613|Serratia	1236|Gammaproteobacteria	K	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. Binds to the 16 bp palindromic sequence 5'-CTGTATATATATACAG-3'. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair	lexA	GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006282,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009432,GO:0009605,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0009991,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031668,GO:0032774,GO:0032991,GO:0032993,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0043170,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0046483,GO:0048519,GO:0048523,GO:0048583,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051716,GO:0060255,GO:0065007,GO:0071496,GO:0071704,GO:0080090,GO:0080134,GO:0080135,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001020,GO:2001141	3.4.21.88	ko:K01356	-	M00729	-	-	ko00000,ko00002,ko01000,ko01002,ko03400	-	-	-	LexA_DNA_bind,Peptidase_S24
HKD3_k127_6654201_14	1121920.AUAU01000017_gene1225	1.784e-06	56.0	COG0748@1|root,COG0748@2|Bacteria,3Y2Q3@57723|Acidobacteria	57723|Acidobacteria	P	Pyridoxamine 5'-phosphate oxidase	-	-	-	ko:K07226	-	-	-	-	ko00000	-	-	-	DUF2470,Pyrid_oxidase_2
HKD3_k127_6702695_10	290397.Adeh_3929	2.258e-113	374.0	COG0266@1|root,COG0266@2|Bacteria,1MVHK@1224|Proteobacteria,43791@68525|delta/epsilon subdivisions,2X9X0@28221|Deltaproteobacteria,2YZTI@29|Myxococcales	28221|Deltaproteobacteria	L	Belongs to the FPG family	-	-	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
HKD3_k127_6702695_9	397945.Aave_4261	3.659e-130	421.0	COG1250@1|root,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,2VGZU@28216|Betaproteobacteria,4ACD5@80864|Comamonadaceae	28216|Betaproteobacteria	I	3-hydroxyacyl-CoA dehydrogenase	paaH1	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
HKD3_k127_6702695_15	296591.Bpro_0362	1.648e-90	312.0	COG0715@1|root,COG0715@2|Bacteria,1RCBF@1224|Proteobacteria,2VZS3@28216|Betaproteobacteria	28216|Betaproteobacteria	P	NMT1-like family	-	-	-	-	-	-	-	-	-	-	-	-	NMT1
HKD3_k127_6702695_2	1380394.JADL01000002_gene1394	1.664e-208	659.0	COG0006@1|root,COG0006@2|Bacteria,1MVX5@1224|Proteobacteria,2TRMK@28211|Alphaproteobacteria,2JT4J@204441|Rhodospirillales	204441|Rhodospirillales	E	Metallopeptidase family M24	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M24
HKD3_k127_6702695_12	1449353.JQMQ01000004_gene5932	4.991e-106	359.0	COG2084@1|root,COG2084@2|Bacteria,2GNB0@201174|Actinobacteria,2NHIR@228398|Streptacidiphilus	201174|Actinobacteria	I	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase	-	-	1.1.1.31	ko:K00020	ko00280,ko01100,map00280,map01100	-	R05066	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
HKD3_k127_6702695_14	264198.Reut_B5849	4.147e-92	321.0	COG3181@1|root,COG3181@2|Bacteria,1N4MC@1224|Proteobacteria,2VKJS@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HKD3_k127_6702695_13	1125863.JAFN01000001_gene3237	2.133e-99	331.0	COG1024@1|root,COG1024@2|Bacteria,1MWZC@1224|Proteobacteria,42QPM@68525|delta/epsilon subdivisions,2WMRG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	4.2.1.17	ko:K01715	ko00650,ko01200,map00650,map01200	-	R03026	RC00831	ko00000,ko00001,ko01000	-	-	iAF987.Gmet_1716	ECH_1
HKD3_k127_6702695_22	1211115.ALIQ01000005_gene4352	8.429e-52	192.0	COG3971@1|root,COG3971@2|Bacteria,1RA35@1224|Proteobacteria,2VFYX@28211|Alphaproteobacteria,3NBWC@45404|Beijerinckiaceae	28211|Alphaproteobacteria	Q	Fumarylacetoacetate (FAA) hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	FAA_hydrolase
HKD3_k127_6702695_17	1298867.AUES01000038_gene820	3.201e-79	292.0	COG0659@1|root,COG0664@1|root,COG0659@2|Bacteria,COG0664@2|Bacteria,1MVWV@1224|Proteobacteria,2UNZ9@28211|Alphaproteobacteria,3K2C1@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	PT	Sulfate permease family	-	-	-	-	-	-	-	-	-	-	-	-	STAS,Sulfate_transp,cNMP_binding
HKD3_k127_6702695_16	640081.Dsui_1107	5.603e-87	293.0	COG0664@1|root,COG0664@2|Bacteria,1MUHT@1224|Proteobacteria,2VI43@28216|Betaproteobacteria,2KY92@206389|Rhodocyclales	206389|Rhodocyclales	K	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Crp_2,cNMP_binding
HKD3_k127_6702695_0	1304883.KI912532_gene541	2e-323	1003.0	COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,2VI0U@28216|Betaproteobacteria,2KV98@206389|Rhodocyclales	206389|Rhodocyclales	I	AMP-dependent synthetase and ligase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
HKD3_k127_6702695_8	640081.Dsui_1109	3.734e-133	430.0	COG0411@1|root,COG0411@2|Bacteria,1MUTY@1224|Proteobacteria,2VJ0Q@28216|Betaproteobacteria,2KVIG@206389|Rhodocyclales	206389|Rhodocyclales	E	COG0411 ABC-type branched-chain amino acid transport systems, ATPase component	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
HKD3_k127_6702695_6	640081.Dsui_1110	2.238e-147	471.0	COG0559@1|root,COG0559@2|Bacteria,1N54M@1224|Proteobacteria,2VIID@28216|Betaproteobacteria,2KVZ8@206389|Rhodocyclales	206389|Rhodocyclales	U	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HKD3_k127_6702695_5	29581.BW37_02824	4.924e-166	531.0	COG4177@1|root,COG4177@2|Bacteria,1MV66@1224|Proteobacteria,2VHRM@28216|Betaproteobacteria,473XU@75682|Oxalobacteraceae	28216|Betaproteobacteria	U	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HKD3_k127_6702695_3	640081.Dsui_1112	6.124e-196	620.0	COG0683@1|root,COG0683@2|Bacteria,1MV5T@1224|Proteobacteria,2VI33@28216|Betaproteobacteria,2KVMF@206389|Rhodocyclales	206389|Rhodocyclales	E	ABC-type branched-chain amino acid transport systems, periplasmic component	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
HKD3_k127_6702695_7	159087.Daro_0254	5.688e-140	449.0	COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,2VHET@28216|Betaproteobacteria,2KUVN@206389|Rhodocyclales	206389|Rhodocyclales	E	ABC-type branched-chain amino acid transport systems, ATPase component	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
HKD3_k127_6702695_24	1163407.UU7_02067	1.348e-25	111.0	COG2315@1|root,COG2315@2|Bacteria,1RHEZ@1224|Proteobacteria,1S69J@1236|Gammaproteobacteria,1X8AE@135614|Xanthomonadales	135614|Xanthomonadales	S	YjbR	-	-	-	-	-	-	-	-	-	-	-	-	YjbR
HKD3_k127_6702695_4	85643.Tmz1t_3359	6.113e-175	565.0	COG1541@1|root,COG1541@2|Bacteria,1MV1W@1224|Proteobacteria,2VHRJ@28216|Betaproteobacteria,2KUZ8@206389|Rhodocyclales	206389|Rhodocyclales	H	Coenzyme F390 synthetase	-	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding
HKD3_k127_6702695_21	472759.Nhal_3549	5.379e-57	206.0	COG0664@1|root,COG0664@2|Bacteria,1MXID@1224|Proteobacteria,1S5PP@1236|Gammaproteobacteria,1WYN6@135613|Chromatiales	135613|Chromatiales	K	SMART cyclic nucleotide-binding	-	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
HKD3_k127_6702695_1	864073.HFRIS_022308	2.893e-226	711.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2VHGR@28216|Betaproteobacteria,472HD@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	Belongs to the aldehyde dehydrogenase family	gabD	-	1.2.1.16,1.2.1.20,1.2.1.79	ko:K00135	ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120	M00027	R00713,R00714,R02401	RC00080	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
HKD3_k127_6702695_20	1121035.AUCH01000008_gene1043	6.882e-72	264.0	COG0697@1|root,COG0697@2|Bacteria,1MYHQ@1224|Proteobacteria,2VJMU@28216|Betaproteobacteria,2KVWH@206389|Rhodocyclales	206389|Rhodocyclales	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HKD3_k127_6702695_11	1095769.CAHF01000013_gene3397	2.1e-110	366.0	COG1968@1|root,COG1968@2|Bacteria,1MX02@1224|Proteobacteria,2VHSA@28216|Betaproteobacteria,473CE@75682|Oxalobacteraceae	28216|Betaproteobacteria	V	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin	uppP	-	3.6.1.27	ko:K06153	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	BacA
HKD3_k127_6702695_19	1038867.AXAY01000027_gene7530	2.797e-74	271.0	COG0395@1|root,COG0395@2|Bacteria,1R8XQ@1224|Proteobacteria,2TS5W@28211|Alphaproteobacteria,3K37V@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
HKD3_k127_6702695_18	1089551.KE386572_gene556	2.264e-74	258.0	COG1175@1|root,COG1175@2|Bacteria,1MWB7@1224|Proteobacteria,2TQZY@28211|Alphaproteobacteria,4BQJF@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	G	Carbohydrate ABC transporter membrane protein 1, CUT1 family	-	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
HKD3_k127_6870137_1	987059.RBXJA2T_16907	2.129e-91	301.0	COG0055@1|root,COG0055@2|Bacteria,1MUFU@1224|Proteobacteria,2VHDZ@28216|Betaproteobacteria,1KJX9@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits	atpD	-	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_N
HKD3_k127_6870137_2	883126.HMPREF9710_02395	1.355e-46	180.0	COG0355@1|root,COG0355@2|Bacteria,1RHE4@1224|Proteobacteria,2VR2R@28216|Betaproteobacteria,474C5@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpC	-	-	ko:K02114	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_DE,ATP-synt_DE_N
HKD3_k127_6870137_0	420324.KI912014_gene9393	4.131e-263	832.0	COG3243@1|root,COG3243@2|Bacteria,1MUNE@1224|Proteobacteria,2TRK4@28211|Alphaproteobacteria,1JS63@119045|Methylobacteriaceae	28211|Alphaproteobacteria	I	Protein of unknown function (DUF3141)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3141
HKD3_k127_6918578_5	1123393.KB891317_gene2299	1.81e-65	229.0	COG0750@1|root,COG0750@2|Bacteria,1MU91@1224|Proteobacteria,2VHBW@28216|Betaproteobacteria,1KREM@119069|Hydrogenophilales	119069|Hydrogenophilales	M	Peptidase family M50	-	-	-	ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_M50
HKD3_k127_6918578_0	1000565.METUNv1_01292	7.358e-281	883.0	COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,2VHTX@28216|Betaproteobacteria,2KV13@206389|Rhodocyclales	206389|Rhodocyclales	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamA	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
HKD3_k127_6918578_7	1163617.SCD_n01626	1.444e-55	200.0	COG2825@1|root,COG2825@2|Bacteria,1RD8X@1224|Proteobacteria,2VRZI@28216|Betaproteobacteria	28216|Betaproteobacteria	M	Belongs to the skp family	ompH	-	-	ko:K06142	-	-	-	-	ko00000	-	-	-	OmpH
HKD3_k127_6918578_3	572477.Alvin_2054	2.635e-99	336.0	COG1044@1|root,COG1044@2|Bacteria,1MUX6@1224|Proteobacteria,1RNYI@1236|Gammaproteobacteria,1WWER@135613|Chromatiales	135613|Chromatiales	M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxD	-	2.3.1.191	ko:K02536	ko00540,ko01100,map00540,map01100	M00060	R04550	RC00039,RC00166	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hexapep,Hexapep_2,LpxD
HKD3_k127_6918578_9	305700.B447_05283	8.919e-30	135.0	COG0764@1|root,COG0764@2|Bacteria,1RH2T@1224|Proteobacteria,2VRKQ@28216|Betaproteobacteria,2KWAJ@206389|Rhodocyclales	206389|Rhodocyclales	I	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs	fabZ	-	4.2.1.59	ko:K02372	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07764,R10117,R10121	RC00831,RC01095	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FabA
HKD3_k127_6918578_2	522306.CAP2UW1_2865	1.228e-99	339.0	COG1043@1|root,COG1043@2|Bacteria,1MUHQ@1224|Proteobacteria,2VHDG@28216|Betaproteobacteria,1KPN9@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	I	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxA	-	2.3.1.129	ko:K00677	ko00540,ko01100,ko01503,map00540,map01100,map01503	M00060	R04567	RC00039,RC00055	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Acetyltransf_11,Hexapep
HKD3_k127_6918578_1	1121004.ATVC01000010_gene1039	1.889e-117	389.0	COG0763@1|root,COG0763@2|Bacteria,1MVBI@1224|Proteobacteria,2VIBP@28216|Betaproteobacteria,2KPQB@206351|Neisseriales	206351|Neisseriales	M	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxB	-	2.4.1.182	ko:K00748	ko00540,ko01100,map00540,map01100	M00060	R04606	RC00005,RC00059	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT19	-	LpxB
HKD3_k127_6918578_6	477184.KYC_25388	3.766e-63	246.0	COG0164@1|root,COG0164@2|Bacteria,1RA65@1224|Proteobacteria,2VQ06@28216|Betaproteobacteria,3T3JQ@506|Alcaligenaceae	28216|Betaproteobacteria	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhB	-	3.1.26.4	ko:K03470	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_HII
HKD3_k127_6918578_4	204773.HEAR3324	3.913e-73	263.0	COG2188@1|root,COG2188@2|Bacteria,1R790@1224|Proteobacteria,2VKB7@28216|Betaproteobacteria,476XB@75682|Oxalobacteraceae	28216|Betaproteobacteria	K	UTRA	-	-	-	ko:K03710	-	-	-	-	ko00000,ko03000	-	-	-	GntR,UTRA
HKD3_k127_6918578_8	94624.Bpet0415	3.335e-39	148.0	COG2721@1|root,COG2721@2|Bacteria,1MZBN@1224|Proteobacteria,2VU0R@28216|Betaproteobacteria,3T7XU@506|Alcaligenaceae	28216|Betaproteobacteria	G	SAF	-	-	4.4.1.24	ko:K16845	ko00270,map00270	-	R07633	RC01785	ko00000,ko00001,ko01000	-	-	-	SAF
HKD3_k127_6952631_17	1002339.HMPREF9373_0662	2.069e-12	66.0	COG0492@1|root,COG0492@2|Bacteria,1MV15@1224|Proteobacteria,1RMEX@1236|Gammaproteobacteria,3NJMY@468|Moraxellaceae	1236|Gammaproteobacteria	C	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family	trxB	GO:0000166,GO:0003674,GO:0003824,GO:0004791,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050660,GO:0050662,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901265,GO:1901363,GO:1990748	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	iPC815.YPO1374	Pyr_redox_2
HKD3_k127_6952631_14	204773.HEAR1016	9.744e-43	166.0	COG2840@1|root,COG2840@2|Bacteria,1RH34@1224|Proteobacteria,2VQ2S@28216|Betaproteobacteria,472P7@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Small MutS-related domain	smrA	-	-	-	-	-	-	-	-	-	-	-	Smr
HKD3_k127_6952631_11	640081.Dsui_0696	4.382e-80	278.0	COG1716@1|root,COG2114@1|root,COG1716@2|Bacteria,COG2114@2|Bacteria,1NAJG@1224|Proteobacteria,2VJW8@28216|Betaproteobacteria,2KWIW@206389|Rhodocyclales	206389|Rhodocyclales	T	Forkhead associated domain	-	-	-	-	-	-	-	-	-	-	-	-	FHA,Guanylate_cyc
HKD3_k127_6952631_8	85643.Tmz1t_1219	1.24e-109	361.0	COG0388@1|root,COG0388@2|Bacteria,1MUUB@1224|Proteobacteria,2VIR4@28216|Betaproteobacteria,2KV3M@206389|Rhodocyclales	206389|Rhodocyclales	S	Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase	-	-	3.5.5.1	ko:K01501,ko:K11206	ko00380,ko00460,ko00627,ko00643,ko00910,ko01120,map00380,map00460,map00627,map00643,map00910,map01120	-	R00540,R01887,R03093,R03542,R05591,R07855	RC00315,RC00325,RC00617,RC00959,RC02811	ko00000,ko00001,ko01000	-	-	-	CN_hydrolase
HKD3_k127_6952631_1	1163617.SCD_n01950	1.442e-257	858.0	COG3164@1|root,COG3164@2|Bacteria,1MXWF@1224|Proteobacteria,2VH52@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Protein of unknown function	-	-	-	-	-	-	-	-	-	-	-	-	AsmA_2,DUF3971
HKD3_k127_6952631_0	243365.CV_2095	1.664e-266	848.0	COG1391@1|root,COG1391@2|Bacteria,1MU4I@1224|Proteobacteria,2VH5B@28216|Betaproteobacteria,2KQ5Z@206351|Neisseriales	206351|Neisseriales	H	Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell	glnE	-	2.7.7.42,2.7.7.89	ko:K00982	-	-	-	-	ko00000,ko01000	-	-	-	GlnD_UR_UTase,GlnE
HKD3_k127_6952631_6	1230338.MOMA_07946	1.61e-140	452.0	COG0115@1|root,COG0115@2|Bacteria,1MVB0@1224|Proteobacteria,1RP6Z@1236|Gammaproteobacteria,3NK5G@468|Moraxellaceae	1236|Gammaproteobacteria	E	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family	ilvE	GO:0003674,GO:0003824,GO:0004084,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006531,GO:0006532,GO:0006551,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009081,GO:0009082,GO:0009098,GO:0009099,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0019752,GO:0042802,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	iB21_1397.B21_03597,iECBD_1354.ECBD_4269,iECB_1328.ECB_03648,iECD_1391.ECD_03648,iECO103_1326.ECO103_4394	Aminotran_4
HKD3_k127_6952631_16	1392838.AWNM01000031_gene60	8.714e-16	89.0	COG4391@1|root,COG4391@2|Bacteria,1N7QM@1224|Proteobacteria,2VVV6@28216|Betaproteobacteria,3T4S6@506|Alcaligenaceae	28216|Betaproteobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	zf-CHCC
HKD3_k127_6952631_9	580332.Slit_2100	2.705e-101	340.0	COG0859@1|root,COG0859@2|Bacteria,1MXA2@1224|Proteobacteria,2VHHX@28216|Betaproteobacteria,44UZE@713636|Nitrosomonadales	28216|Betaproteobacteria	M	Glycosyltransferase family 9 (heptosyltransferase)	rfaF	-	-	ko:K02843	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9
HKD3_k127_6952631_15	1123487.KB892835_gene3512	3.953e-31	134.0	COG3631@1|root,COG3631@2|Bacteria,1QXIX@1224|Proteobacteria,2WH4R@28216|Betaproteobacteria,2KZY7@206389|Rhodocyclales	206389|Rhodocyclales	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_3
HKD3_k127_6952631_3	1120999.JONM01000005_gene3839	9.052e-217	695.0	COG0312@1|root,COG0312@2|Bacteria,1MUSK@1224|Proteobacteria,2VHJ9@28216|Betaproteobacteria,2KPJ1@206351|Neisseriales	206351|Neisseriales	S	TldD PmbA family protein	tldD	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
HKD3_k127_6952631_10	859657.RPSI07_mp0605	1.633e-94	319.0	COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,2VJNG@28216|Betaproteobacteria,1K20Y@119060|Burkholderiaceae	28216|Betaproteobacteria	E	abc transporter	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
HKD3_k127_6952631_2	159087.Daro_4098	2.018e-231	732.0	COG0411@1|root,COG0559@1|root,COG4177@1|root,COG0411@2|Bacteria,COG0559@2|Bacteria,COG4177@2|Bacteria,1MUTY@1224|Proteobacteria,2VH2P@28216|Betaproteobacteria,2KUY7@206389|Rhodocyclales	206389|Rhodocyclales	P	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01995,ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C,BPD_transp_2
HKD3_k127_6952631_7	1235457.C404_07155	1.48e-122	403.0	COG0559@1|root,COG0559@2|Bacteria,1MXMC@1224|Proteobacteria,2VJ1Y@28216|Betaproteobacteria,1K081@119060|Burkholderiaceae	28216|Betaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HKD3_k127_6952631_5	595537.Varpa_1323	2.441e-150	489.0	COG0683@1|root,COG0683@2|Bacteria,1MXR4@1224|Proteobacteria,2VHP9@28216|Betaproteobacteria,4ACT4@80864|Comamonadaceae	28216|Betaproteobacteria	E	PFAM Extracellular ligand-binding receptor	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
HKD3_k127_6952631_13	338969.Rfer_2428	6.352e-54	192.0	COG1970@1|root,COG1970@2|Bacteria,1RHG8@1224|Proteobacteria,2VT9K@28216|Betaproteobacteria,4ADW1@80864|Comamonadaceae	28216|Betaproteobacteria	M	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell	mscL	-	-	ko:K03282	-	-	-	-	ko00000,ko02000	1.A.22.1	-	-	MscL
HKD3_k127_6952631_12	1123392.AQWL01000004_gene2515	2.003e-56	198.0	COG0347@1|root,COG0347@2|Bacteria,1RGWK@1224|Proteobacteria,2VSEZ@28216|Betaproteobacteria,1KT59@119069|Hydrogenophilales	119069|Hydrogenophilales	K	Nitrogen regulatory protein P-II	-	-	-	ko:K04751	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	P-II
HKD3_k127_6952631_4	1485544.JQKP01000001_gene1143	1.666e-206	659.0	COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,1MU9U@1224|Proteobacteria,2VJ8C@28216|Betaproteobacteria,44V57@713636|Nitrosomonadales	28216|Betaproteobacteria	H	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source	nadE	-	6.3.1.5,6.3.5.1	ko:K01916,ko:K01950	ko00760,ko01100,map00760,map01100	M00115	R00189,R00257	RC00010,RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase,NAD_synthase
HKD3_k127_722911_7	1288494.EBAPG3_17600	7.953e-135	439.0	COG0064@1|root,COG0064@2|Bacteria,1MUKG@1224|Proteobacteria,2VI3A@28216|Betaproteobacteria,371YV@32003|Nitrosomonadales	28216|Betaproteobacteria	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatB	-	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	GatB_N,GatB_Yqey
HKD3_k127_722911_2	76114.ebA3030	9.016e-213	676.0	COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,2VIG3@28216|Betaproteobacteria,2KUD1@206389|Rhodocyclales	206389|Rhodocyclales	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
HKD3_k127_722911_15	1123392.AQWL01000002_gene2021	7.927e-31	125.0	COG0721@1|root,COG0721@2|Bacteria,1MZQP@1224|Proteobacteria,2VUFB@28216|Betaproteobacteria,1KRUT@119069|Hydrogenophilales	119069|Hydrogenophilales	J	Glu-tRNAGln amidotransferase C subunit	-	-	-	-	-	-	-	-	-	-	-	-	Glu-tRNAGln
HKD3_k127_722911_3	1123487.KB892834_gene2786	4.8e-194	612.0	COG1077@1|root,COG1077@2|Bacteria,1MUMW@1224|Proteobacteria,2VIR9@28216|Betaproteobacteria,2KUHG@206389|Rhodocyclales	206389|Rhodocyclales	D	Rod shape-determining protein MreB	mreB	-	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
HKD3_k127_722911_10	1095769.CAHF01000014_gene3091	9.545e-76	264.0	COG1792@1|root,COG1792@2|Bacteria,1N8ZS@1224|Proteobacteria,2VK0Y@28216|Betaproteobacteria,47326@75682|Oxalobacteraceae	28216|Betaproteobacteria	M	Involved in formation and maintenance of cell shape	mreC	-	-	ko:K03570	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreC
HKD3_k127_722911_13	323848.Nmul_A0318	1.812e-41	158.0	COG2891@1|root,COG2891@2|Bacteria,1RBNF@1224|Proteobacteria,2VQQ3@28216|Betaproteobacteria,373D2@32003|Nitrosomonadales	28216|Betaproteobacteria	M	shape-determining protein MreD	mreD	-	-	ko:K03571	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreD
HKD3_k127_722911_0	522306.CAP2UW1_0695	8.24e-269	846.0	COG0768@1|root,COG0768@2|Bacteria,1MV8C@1224|Proteobacteria,2VHBZ@28216|Betaproteobacteria,1KPQQ@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	M	Penicillin-binding protein 2	mrdA	-	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	-	PBP_dimer,Transpeptidase
HKD3_k127_722911_6	640081.Dsui_0892	8.936e-142	458.0	COG0772@1|root,COG0772@2|Bacteria,1MUK3@1224|Proteobacteria,2VH8Q@28216|Betaproteobacteria,2KURV@206389|Rhodocyclales	206389|Rhodocyclales	M	Peptidoglycan polymerase that is essential for cell wall elongation	mrdB	-	-	ko:K05837	-	-	-	-	ko00000,ko03036	-	-	-	FTSW_RODA_SPOVE
HKD3_k127_722911_1	1458427.BAWN01000003_gene144	8.178e-226	715.0	COG2066@1|root,COG2905@1|root,COG2066@2|Bacteria,COG2905@2|Bacteria,1MWB5@1224|Proteobacteria,2VIM8@28216|Betaproteobacteria,4ADKU@80864|Comamonadaceae	28216|Betaproteobacteria	E	Belongs to the glutaminase family	glsA	-	3.5.1.2	ko:K01425	ko00220,ko00250,ko00471,ko01100,ko04724,ko04727,ko04964,ko05206,ko05230,map00220,map00250,map00471,map01100,map04724,map04727,map04964,map05206,map05230	-	R00256,R01579	RC00010,RC02798	ko00000,ko00001,ko01000	-	-	-	Glutaminase
HKD3_k127_722911_5	1379270.AUXF01000001_gene2209	1.571e-145	471.0	COG0332@1|root,COG0332@2|Bacteria,1ZU9P@142182|Gemmatimonadetes	142182|Gemmatimonadetes	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	-	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
HKD3_k127_722911_17	420662.Mpe_A0013	1.162e-08	60.0	2CIC8@1|root,33JK4@2|Bacteria,1NH5Z@1224|Proteobacteria,2VYDU@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_722911_14	1149133.ppKF707_1197	4.835e-31	141.0	2CNK3@1|root,32SH9@2|Bacteria,1N02U@1224|Proteobacteria,1SA77@1236|Gammaproteobacteria,1YGFT@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	S	Protein of Unknown function (DUF2784)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2784
HKD3_k127_722911_16	880071.Fleli_0273	5.898e-22	104.0	COG3183@1|root,COG3183@2|Bacteria,4NTGK@976|Bacteroidetes,47RKJ@768503|Cytophagia	976|Bacteroidetes	L	PFAM HNH endonuclease	-	-	-	ko:K07451	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	HNH
HKD3_k127_722911_9	62928.azo0179	5.227e-90	305.0	COG0797@1|root,COG3087@1|root,COG0797@2|Bacteria,COG3087@2|Bacteria,1MZ8S@1224|Proteobacteria,2VJAN@28216|Betaproteobacteria,2KUPW@206389|Rhodocyclales	206389|Rhodocyclales	DM	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides	rlpA	-	-	ko:K03642	-	-	-	-	ko00000	-	-	-	DPBB_1,SPOR
HKD3_k127_722911_4	1163617.SCD_n00676	3.649e-154	507.0	COG0823@1|root,COG0823@2|Bacteria,1MV09@1224|Proteobacteria,2VH9R@28216|Betaproteobacteria	28216|Betaproteobacteria	U	Involved in the tonB-independent uptake of proteins	tolB	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40,TolB_N
HKD3_k127_722911_12	1288494.EBAPG3_9070	3.246e-50	187.0	COG2885@1|root,COG2885@2|Bacteria,1MZTV@1224|Proteobacteria,2VSP6@28216|Betaproteobacteria,3736X@32003|Nitrosomonadales	28216|Betaproteobacteria	M	Belongs to the ompA family	pal	-	-	ko:K03640	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	OmpA
HKD3_k127_722911_11	640081.Dsui_0477	4.148e-55	205.0	COG1729@1|root,COG1729@2|Bacteria,1MUSV@1224|Proteobacteria,2VIPC@28216|Betaproteobacteria,2KW31@206389|Rhodocyclales	206389|Rhodocyclales	D	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division	cpoB	-	-	-	-	-	-	-	-	-	-	-	TPR_6,TolA_bind_tri
HKD3_k127_722911_8	640510.BC1001_0305	1.368e-115	405.0	COG1194@1|root,COG1194@2|Bacteria,1MUD4@1224|Proteobacteria,2VH21@28216|Betaproteobacteria,1K2KI@119060|Burkholderiaceae	28216|Betaproteobacteria	L	a g-specific adenine glycosylase	mutY	-	-	ko:K03575	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD,NUDIX_4
HKD3_k127_7252994_5	1123393.KB891329_gene1022	4.639e-39	146.0	COG0582@1|root,COG0582@2|Bacteria,1NWGS@1224|Proteobacteria,2VKWM@28216|Betaproteobacteria,1KTHJ@119069|Hydrogenophilales	119069|Hydrogenophilales	L	Phage integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
HKD3_k127_7252994_6	1121121.KB894312_gene3241	1.341e-09	66.0	2DREZ@1|root,33BFB@2|Bacteria,1UPXP@1239|Firmicutes,4IVCS@91061|Bacilli,2743X@186822|Paenibacillaceae	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_7252994_2	1458357.BG58_04155	1.159e-110	371.0	COG0600@1|root,COG0600@2|Bacteria,1MVD2@1224|Proteobacteria,2VI9N@28216|Betaproteobacteria,1K17T@119060|Burkholderiaceae	28216|Betaproteobacteria	P	binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
HKD3_k127_7252994_1	1229205.BUPH_02276	5.295e-126	409.0	COG1116@1|root,COG1116@2|Bacteria,1N7FP@1224|Proteobacteria,2VHGX@28216|Betaproteobacteria,1KGMZ@119060|Burkholderiaceae	28216|Betaproteobacteria	P	PFAM ABC transporter related	-	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
HKD3_k127_7252994_3	1211115.ALIQ01000230_gene1670	2.598e-92	334.0	COG0715@1|root,COG0715@2|Bacteria,1R5S6@1224|Proteobacteria,2U3X1@28211|Alphaproteobacteria,3NB44@45404|Beijerinckiaceae	28211|Alphaproteobacteria	P	NMT1-like family	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1_2
HKD3_k127_7252994_4	857087.Metme_3221	3.536e-42	172.0	COG4249@1|root,COG4249@2|Bacteria,1QU7W@1224|Proteobacteria,1RZ8P@1236|Gammaproteobacteria,1XG8B@135618|Methylococcales	135618|Methylococcales	S	Peptidase C13 family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C13
HKD3_k127_7252994_0	323848.Nmul_A1550	1.268e-186	590.0	COG0498@1|root,COG0498@2|Bacteria,1MUWQ@1224|Proteobacteria,2VHR6@28216|Betaproteobacteria,372MN@32003|Nitrosomonadales	28216|Betaproteobacteria	E	Threonine synthase	thrC	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP,Thr_synth_N
HKD3_k127_7262036_6	196367.JNFG01000009_gene6255	3.121e-12	71.0	COG0346@1|root,COG0346@2|Bacteria,1MUBT@1224|Proteobacteria,2VPKK@28216|Betaproteobacteria,1K4UG@119060|Burkholderiaceae	28216|Betaproteobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	1.13.11.2	ko:K00446	ko00361,ko00362,ko00622,ko00643,ko01100,ko01120,ko01220,map00361,map00362,map00622,map00643,map01100,map01120,map01220	M00569	R00816,R04089,R05295,R05404,R05406,R07795	RC00387,RC00643,RC01075,RC01364,RC01914	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	Glyoxalase
HKD3_k127_7262036_2	1123354.AUDR01000014_gene925	2.189e-95	320.0	COG0030@1|root,COG0030@2|Bacteria,1MVNU@1224|Proteobacteria,2VH15@28216|Betaproteobacteria,1KSRA@119069|Hydrogenophilales	119069|Hydrogenophilales	J	Ribosomal RNA adenine dimethylases	-	-	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
HKD3_k127_7262036_1	1123367.C666_01820	2.564e-100	338.0	COG1995@1|root,COG1995@2|Bacteria,1MX5W@1224|Proteobacteria,2VJN0@28216|Betaproteobacteria,2KV6F@206389|Rhodocyclales	206389|Rhodocyclales	H	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)	pdxA	-	1.1.1.262	ko:K00097	ko00750,ko01100,map00750,map01100	M00124	R05681,R05837,R07406	RC00089,RC00675,RC01475	ko00000,ko00001,ko00002,ko01000	-	-	-	PdxA
HKD3_k127_7262036_0	1128912.GMES_1519	9.813e-207	671.0	COG1501@1|root,COG1501@2|Bacteria,1MWNJ@1224|Proteobacteria,1RMJ9@1236|Gammaproteobacteria,4679Q@72275|Alteromonadaceae	1236|Gammaproteobacteria	G	Belongs to the glycosyl hydrolase 31 family	yicI	GO:0003674,GO:0003824,GO:0004553,GO:0005488,GO:0005515,GO:0016787,GO:0016798,GO:0042802,GO:0080176	3.2.1.177	ko:K01811	-	-	-	-	ko00000,ko01000	-	GH31	-	Gal_mutarotas_2,Glyco_hydro_31
HKD3_k127_7262036_4	574966.KB898648_gene780	3.652e-93	329.0	COG3386@1|root,COG3386@2|Bacteria,1MWTR@1224|Proteobacteria,1RSKQ@1236|Gammaproteobacteria,1XNK5@135619|Oceanospirillales	135619|Oceanospirillales	G	SMP-30/Gluconolaconase/LRE-like region	-	-	-	ko:K14274	ko00040,map00040	-	R02427	RC00713	ko00000,ko00001,ko01000	-	-	-	SGL
HKD3_k127_7262036_3	1057002.KB905370_gene3449	2.995e-95	318.0	COG3836@1|root,COG3836@2|Bacteria,1MUSG@1224|Proteobacteria,2TT2W@28211|Alphaproteobacteria,4B76M@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	Belongs to the HpcH HpaI aldolase family	-	-	4.1.2.20	ko:K01630	ko00053,map00053	-	R02754,R03277	RC00307,RC00435	ko00000,ko00001,ko01000	-	-	-	HpcH_HpaI
HKD3_k127_7262036_5	1156919.QWC_06329	6.819e-35	134.0	COG0129@1|root,COG0129@2|Bacteria,1MV4I@1224|Proteobacteria,2VKKY@28216|Betaproteobacteria,3T5BW@506|Alcaligenaceae	28216|Betaproteobacteria	EG	Belongs to the IlvD Edd family	ilvD3	-	4.2.1.82,4.2.1.9	ko:K01687,ko:K22186	ko00040,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00040,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R02429,R04441,R05070	RC00468,RC00543,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
HKD3_k127_7271973_0	1000565.METUNv1_00744	3.764e-197	625.0	COG0527@1|root,COG0527@2|Bacteria,1MW3H@1224|Proteobacteria,2VINP@28216|Betaproteobacteria,2KUEA@206389|Rhodocyclales	206389|Rhodocyclales	E	Belongs to the aspartokinase family	lysC	-	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT,ACT_7
HKD3_k127_7271973_1	1000565.METUNv1_00622	6.397e-197	621.0	COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,2VI6I@28216|Betaproteobacteria,2KUW2@206389|Rhodocyclales	206389|Rhodocyclales	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	-	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
HKD3_k127_7271973_6	62928.azo1626	4.03e-36	139.0	COG0236@1|root,COG0236@2|Bacteria,1MZ4P@1224|Proteobacteria,2VTZH@28216|Betaproteobacteria,2KWX1@206389|Rhodocyclales	206389|Rhodocyclales	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	acpP	-	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
HKD3_k127_7271973_5	292415.Tbd_1549	7.608e-103	343.0	COG1028@1|root,COG1028@2|Bacteria,1MU6X@1224|Proteobacteria,2VJ3S@28216|Betaproteobacteria,1KS53@119069|Hydrogenophilales	119069|Hydrogenophilales	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HKD3_k127_7271973_4	85643.Tmz1t_2327	4.691e-115	379.0	COG0331@1|root,COG0331@2|Bacteria,1MV6N@1224|Proteobacteria,2VJF7@28216|Betaproteobacteria,2KV8M@206389|Rhodocyclales	206389|Rhodocyclales	I	malonyl CoA-acyl carrier protein transacylase	fabD	-	2.3.1.39	ko:K00645	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	M00082	R01626,R11671	RC00004,RC00039,RC02727	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyl_transf_1
HKD3_k127_7271973_3	335283.Neut_0470	9.459e-131	428.0	COG0332@1|root,COG0332@2|Bacteria,1MU9N@1224|Proteobacteria,2VI2A@28216|Betaproteobacteria,371X7@32003|Nitrosomonadales	28216|Betaproteobacteria	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	fabH	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
HKD3_k127_7271973_2	265072.Mfla_1508	1.686e-135	443.0	COG0416@1|root,COG0416@2|Bacteria,1MVM3@1224|Proteobacteria,2VI25@28216|Betaproteobacteria,2KMA0@206350|Nitrosomonadales	206350|Nitrosomonadales	I	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA	plsX	-	2.3.1.15	ko:K03621	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FA_synthesis
HKD3_k127_7271973_7	395494.Galf_1555	3.202e-26	111.0	COG0333@1|root,COG0333@2|Bacteria,1N6RF@1224|Proteobacteria,2VVP5@28216|Betaproteobacteria,44W39@713636|Nitrosomonadales	28216|Betaproteobacteria	J	Belongs to the bacterial ribosomal protein bL32 family	rpmF	-	-	ko:K02911	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_L32p
HKD3_k127_7271973_8	1437824.BN940_05391	4.389e-05	46.0	COG1399@1|root,COG1399@2|Bacteria,1PGKW@1224|Proteobacteria,2VUIG@28216|Betaproteobacteria,3T4RJ@506|Alcaligenaceae	28216|Betaproteobacteria	S	Uncharacterized ACR, COG1399	-	-	-	ko:K07040	-	-	-	-	ko00000	-	-	-	DUF177
HKD3_k127_7293153_3	991905.SL003B_3820	8.641e-33	127.0	COG1574@1|root,COG1574@2|Bacteria,1QVE6@1224|Proteobacteria,2TSU6@28211|Alphaproteobacteria,4BQES@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Pfam:DUF1446	-	-	-	-	-	-	-	-	-	-	-	-	AtuA
HKD3_k127_7293153_2	991905.SL003B_3821	5.233e-43	163.0	2CDKX@1|root,32RXZ@2|Bacteria,1RKGY@1224|Proteobacteria,2V2J4@28211|Alphaproteobacteria,4BSZ7@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Domain of unknown function (DUF4387)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4387
HKD3_k127_7293153_0	1394178.AWOO02000004_gene2433	2.638e-93	313.0	COG0500@1|root,COG2226@2|Bacteria,2GNTH@201174|Actinobacteria	201174|Actinobacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
HKD3_k127_7293153_1	640512.BC1003_0703	6.477e-46	169.0	COG0346@1|root,COG0346@2|Bacteria,1RGVH@1224|Proteobacteria,2W3WX@28216|Betaproteobacteria,1K8W6@119060|Burkholderiaceae	28216|Betaproteobacteria	E	Glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HKD3_k127_7293153_4	1007105.PT7_0956	7.144e-29	116.0	COG0329@1|root,COG0329@2|Bacteria,1MXI1@1224|Proteobacteria,2W0AM@28216|Betaproteobacteria,3T617@506|Alcaligenaceae	28216|Betaproteobacteria	EM	Dihydrodipicolinate synthetase family	-	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
HKD3_k127_7310622_1	1158292.JPOE01000005_gene471	1.156e-235	737.0	COG0499@1|root,COG0499@2|Bacteria,1MUQ2@1224|Proteobacteria,2VH57@28216|Betaproteobacteria,1KJB5@119065|unclassified Burkholderiales	28216|Betaproteobacteria	F	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine	ahcY	GO:0000096,GO:0000097,GO:0000166,GO:0001666,GO:0002376,GO:0002437,GO:0002439,GO:0002544,GO:0003674,GO:0003824,GO:0004013,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006152,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0006950,GO:0006952,GO:0006954,GO:0006955,GO:0007584,GO:0007610,GO:0007622,GO:0007623,GO:0008150,GO:0008152,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009066,GO:0009069,GO:0009116,GO:0009119,GO:0009164,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016053,GO:0016054,GO:0016787,GO:0016801,GO:0016802,GO:0017076,GO:0017144,GO:0019439,GO:0019510,GO:0019752,GO:0030554,GO:0031667,GO:0033353,GO:0034641,GO:0034655,GO:0034656,GO:0036094,GO:0036293,GO:0042219,GO:0042221,GO:0042278,GO:0042454,GO:0042745,GO:0042802,GO:0042995,GO:0043005,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044272,GO:0044273,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046130,GO:0046394,GO:0046395,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0046700,GO:0048037,GO:0048511,GO:0048512,GO:0050662,GO:0050667,GO:0050896,GO:0051186,GO:0051187,GO:0051287,GO:0055086,GO:0070482,GO:0071268,GO:0071704,GO:0072521,GO:0072523,GO:0097159,GO:0097458,GO:0098604,GO:0120025,GO:1901135,GO:1901136,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607,GO:1901657,GO:1901658	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
HKD3_k127_7310622_12	62928.azo1600	4.423e-69	248.0	2DBFU@1|root,2Z90B@2|Bacteria,1PI0M@1224|Proteobacteria,2WGPR@28216|Betaproteobacteria,2KW4Y@206389|Rhodocyclales	206389|Rhodocyclales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_7310622_7	272560.BPSL3429	4.559e-151	486.0	COG1902@1|root,COG1902@2|Bacteria,1MVE0@1224|Proteobacteria,2VHDY@28216|Betaproteobacteria,1K3NA@119060|Burkholderiaceae	28216|Betaproteobacteria	C	NADH flavin oxidoreductase NADH oxidase	namA	-	1.3.1.34	ko:K00219	-	-	-	-	ko00000,ko01000	-	-	-	Oxidored_FMN
HKD3_k127_7310622_3	977880.RALTA_A0174	1.985e-193	623.0	COG0192@1|root,COG0192@2|Bacteria,1MUFQ@1224|Proteobacteria,2VH7U@28216|Betaproteobacteria,1K2M9@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme	metK	-	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
HKD3_k127_7310622_10	748247.AZKH_1458	2.738e-96	330.0	COG0009@1|root,COG0009@2|Bacteria,1MVPM@1224|Proteobacteria,2VIFT@28216|Betaproteobacteria,2KUUI@206389|Rhodocyclales	206389|Rhodocyclales	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine	sua5	-	2.7.7.87	ko:K07566	-	-	R10463	RC00745	ko00000,ko01000,ko03009,ko03016	-	-	-	SUA5,Sua5_yciO_yrdC
HKD3_k127_7310622_13	292415.Tbd_2669	6.102e-47	193.0	COG1073@1|root,COG1073@2|Bacteria,1N1WH@1224|Proteobacteria,2W50B@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Protein of unknown function (DUF3530)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3530
HKD3_k127_7310622_9	1286093.C266_12505	1.129e-114	386.0	COG1929@1|root,COG1929@2|Bacteria,1MVG9@1224|Proteobacteria,2VK3Q@28216|Betaproteobacteria,1K1VI@119060|Burkholderiaceae	28216|Betaproteobacteria	G	Belongs to the glycerate kinase type-1 family	glxK	-	2.7.1.165	ko:K00865	ko00260,ko00561,ko00630,ko01100,ko01120,ko01130,map00260,map00561,map00630,map01100,map01120,map01130	-	R08572	RC00002,RC00428	ko00000,ko00001,ko01000	-	-	-	Gly_kinase
HKD3_k127_7310622_0	684949.ATTJ01000001_gene2189	1.718e-241	762.0	COG4799@1|root,COG4799@2|Bacteria,1WI9K@1297|Deinococcus-Thermus	2|Bacteria	I	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)	-	-	-	-	-	-	-	-	-	-	-	-	Carboxyl_trans
HKD3_k127_7310622_16	326427.Cagg_0380	2.806e-28	117.0	COG3630@1|root,COG3630@2|Bacteria	2|Bacteria	C	sodium ion export across plasma membrane	oadG	GO:0003674,GO:0003824,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0008150,GO:0008948,GO:0015672,GO:0016829,GO:0016830,GO:0016831,GO:0030001,GO:0051179,GO:0051234	4.1.1.3	ko:K01573	ko00620,ko01100,map00620,map01100	-	R00217	RC00040	ko00000,ko00001,ko01000,ko02000	3.B.1.1.1	-	-	OAD_gamma
HKD3_k127_7310622_18	926569.ANT_05820	9.241e-20	104.0	COG4770@1|root,COG4770@2|Bacteria	2|Bacteria	I	CoA carboxylase activity	gcdC	-	2.1.3.1,4.1.1.70,6.4.1.3	ko:K01615,ko:K01965,ko:K02160,ko:K17490	ko00061,ko00280,ko00362,ko00620,ko00630,ko00640,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00280,map00362,map00620,map00630,map00640,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00373,M00376,M00741	R00353,R00742,R01859,R03028	RC00040,RC00097,RC00367,RC00609,RC00832	ko00000,ko00001,ko00002,ko01000,ko02000	3.B.1.1.3	-	-	Biotin_lipoyl
HKD3_k127_7310622_4	684949.ATTJ01000001_gene2186	9.321e-188	593.0	COG1883@1|root,COG1883@2|Bacteria	2|Bacteria	C	oxaloacetate decarboxylase activity	oadB	-	4.1.1.3	ko:K01572	ko00620,ko01100,map00620,map01100	-	R00217	RC00040	ko00000,ko00001,ko01000,ko02000	3.B.1.1.1	-	-	OAD_beta
HKD3_k127_7310622_11	1297742.A176_01248	1.858e-75	255.0	COG0346@1|root,COG0346@2|Bacteria,1RA9H@1224|Proteobacteria,439N8@68525|delta/epsilon subdivisions,2X4ZH@28221|Deltaproteobacteria,2YZW4@29|Myxococcales	28221|Deltaproteobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	4.4.1.5	ko:K01759	ko00620,map00620	-	R02530	RC00004,RC00740	ko00000,ko00001,ko01000	-	-	-	Glyoxalase_4
HKD3_k127_7310622_5	1079460.ATTQ01000002_gene5150	4.534e-164	531.0	COG1748@1|root,COG1748@2|Bacteria,1MY1G@1224|Proteobacteria,2TU0J@28211|Alphaproteobacteria,4B8U8@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	Saccharopine dehydrogenase	lys1	-	1.5.1.7	ko:K00290	ko00300,ko00310,ko01100,ko01110,ko01130,ko01230,map00300,map00310,map01100,map01110,map01130,map01230	M00030,M00032	R00715	RC00217,RC01532	ko00000,ko00001,ko00002,ko01000	-	-	-	Sacchrp_dh_C,Sacchrp_dh_NADP
HKD3_k127_7310622_2	1437824.BN940_16151	2.69e-230	721.0	COG1012@1|root,COG1012@2|Bacteria,1MW72@1224|Proteobacteria,2VIBR@28216|Betaproteobacteria,3T3DW@506|Alcaligenaceae	28216|Betaproteobacteria	C	belongs to the aldehyde dehydrogenase family	-	-	1.2.1.3	ko:K00128	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
HKD3_k127_7310622_8	269799.Gmet_1194	4.276e-132	462.0	2DB7D@1|root,2Z7KR@2|Bacteria,1Q0FB@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_7310622_6	269799.Gmet_1193	6.417e-156	543.0	28JBD@1|root,2Z964@2|Bacteria,1R79R@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_7310622_15	420662.Mpe_A0864	1.203e-32	131.0	COG1917@1|root,COG1917@2|Bacteria,1N0MR@1224|Proteobacteria,2VVE1@28216|Betaproteobacteria,1KMMB@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	AraC_binding,Cupin_2
HKD3_k127_7310622_17	1144305.PMI02_04274	4.11e-22	99.0	COG3497@1|root,COG3497@2|Bacteria,1MX89@1224|Proteobacteria,2TVB3@28211|Alphaproteobacteria,2K4BS@204457|Sphingomonadales	204457|Sphingomonadales	S	Phage tail sheath protein	-	-	-	ko:K06907	-	-	-	-	ko00000	-	-	-	Phage_sheath_1,Phage_sheath_1C
HKD3_k127_7313835_11	1163617.SCD_n00511	7.278e-55	199.0	COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,2VIA1@28216|Betaproteobacteria	28216|Betaproteobacteria	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	spoT	-	2.7.6.5,3.1.7.2	ko:K01139	ko00230,map00230	-	R00336,R00429	RC00002,RC00078	ko00000,ko00001,ko01000,ko03009	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
HKD3_k127_7313835_15	1123487.KB892868_gene1248	2.728e-25	108.0	COG1758@1|root,COG1758@2|Bacteria,1N6TX@1224|Proteobacteria,2VVUH@28216|Betaproteobacteria,2KX71@206389|Rhodocyclales	206389|Rhodocyclales	K	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits	rpoZ	-	2.7.7.6	ko:K03060	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb6
HKD3_k127_7313835_9	743721.Psesu_0536	3.471e-71	247.0	COG0194@1|root,COG0194@2|Bacteria,1MW92@1224|Proteobacteria,1RN09@1236|Gammaproteobacteria,1X4E7@135614|Xanthomonadales	135614|Xanthomonadales	F	Essential for recycling GMP and indirectly, cGMP	gmk	GO:0003674,GO:0003824,GO:0004385,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009150,GO:0009161,GO:0009165,GO:0009167,GO:0009179,GO:0009185,GO:0009259,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0042278,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046483,GO:0046710,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901657	2.7.4.8	ko:K00942	ko00230,ko01100,map00230,map01100	M00050	R00332,R02090	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_kin
HKD3_k127_7313835_7	557598.LHK_01709	5.916e-90	305.0	COG1561@1|root,COG1561@2|Bacteria,1MWRA@1224|Proteobacteria,2VIFC@28216|Betaproteobacteria,2KPIX@206351|Neisseriales	206351|Neisseriales	S	Psort location Cytoplasmic, score 8.96	-	-	-	-	-	-	-	-	-	-	-	-	DUF1732,YicC_N
HKD3_k127_7313835_5	1163617.SCD_n00515	2.553e-128	419.0	COG0515@1|root,COG0515@2|Bacteria,1PJRR@1224|Proteobacteria,2VHMW@28216|Betaproteobacteria	28216|Betaproteobacteria	KLT	serine threonine protein kinase	spkD	-	-	-	-	-	-	-	-	-	-	-	Pkinase
HKD3_k127_7313835_6	1163617.SCD_n00516	6.934e-97	325.0	COG0631@1|root,COG0631@2|Bacteria,1MVE7@1224|Proteobacteria,2VIAV@28216|Betaproteobacteria	28216|Betaproteobacteria	T	protein phosphatase 2C domain protein	pphA	-	3.1.3.16	ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C,PP2C_2
HKD3_k127_7313835_8	159087.Daro_1592	2.653e-75	278.0	COG0847@1|root,COG0847@2|Bacteria,1MV8Z@1224|Proteobacteria,2VH1Z@28216|Betaproteobacteria,2KU7N@206389|Rhodocyclales	206389|Rhodocyclales	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease	dnaQ	-	2.7.7.7	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	RNase_T
HKD3_k127_7313835_0	1005048.CFU_2515	2.557e-275	863.0	COG0855@1|root,COG0855@2|Bacteria,1MUM3@1224|Proteobacteria,2VHH8@28216|Betaproteobacteria,47310@75682|Oxalobacteraceae	28216|Betaproteobacteria	H	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)	ppk	-	2.7.4.1	ko:K00937	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PP_kinase,PP_kinase_C,PP_kinase_N
HKD3_k127_7313835_12	1163617.SCD_n02383	9.562e-55	198.0	COG2062@1|root,COG2062@2|Bacteria,1RIVH@1224|Proteobacteria,2VSSQ@28216|Betaproteobacteria	28216|Betaproteobacteria	T	phosphohistidine phosphatase	sixA	-	-	ko:K08296	-	-	-	-	ko00000,ko01000	-	-	-	His_Phos_1
HKD3_k127_7313835_4	1163617.SCD_n00389	2.655e-138	456.0	COG0248@1|root,COG0248@2|Bacteria,1MV35@1224|Proteobacteria,2VI1K@28216|Betaproteobacteria	28216|Betaproteobacteria	FP	PFAM Ppx GppA phosphatase	ppx	-	3.6.1.11,3.6.1.40	ko:K01524	ko00230,map00230	-	R03409	RC00002	ko00000,ko00001,ko01000	-	-	-	Ppx-GppA
HKD3_k127_7313835_1	395494.Galf_2668	4.111e-238	745.0	COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,2VI5U@28216|Betaproteobacteria,44UZX@713636|Nitrosomonadales	28216|Betaproteobacteria	E	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA	ilvA	GO:0006082,GO:0006520,GO:0006566,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009987,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0071704,GO:1901564,GO:1901605	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP,Thr_dehydrat_C
HKD3_k127_7313835_10	640081.Dsui_0660	5.227e-63	222.0	COG0745@1|root,COG0745@2|Bacteria,1RDYB@1224|Proteobacteria,2VR2Q@28216|Betaproteobacteria,2KWB2@206389|Rhodocyclales	206389|Rhodocyclales	T	cheY-homologous receiver domain	pilG	-	-	ko:K02657	ko02020,ko02025,map02020,map02025	M00507	-	-	ko00000,ko00001,ko00002,ko02022,ko02035,ko02044	-	-	-	Response_reg
HKD3_k127_7313835_13	1163617.SCD_n02925	3.213e-52	188.0	COG0745@1|root,COG0745@2|Bacteria,1RI9T@1224|Proteobacteria,2VSSD@28216|Betaproteobacteria	28216|Betaproteobacteria	T	RESPONSE REGULATOR receiver	pilH	-	-	ko:K02658	ko02020,ko02025,map02020,map02025	M00507	-	-	ko00000,ko00001,ko00002,ko02022,ko02035,ko02044	-	-	-	Response_reg
HKD3_k127_7313835_14	640081.Dsui_0658	5.442e-39	157.0	COG0835@1|root,COG0835@2|Bacteria,1N07Q@1224|Proteobacteria,2VU6N@28216|Betaproteobacteria,2KX20@206389|Rhodocyclales	206389|Rhodocyclales	NT	Chemotaxis signal transduction protein	pilI	-	-	ko:K02659	ko02020,ko02025,map02020,map02025	-	-	-	ko00000,ko00001,ko02035,ko02044	-	-	-	CheW
HKD3_k127_7313835_2	159087.Daro_3896	7.95e-183	596.0	COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2VJBX@28216|Betaproteobacteria,2KU9U@206389|Rhodocyclales	206389|Rhodocyclales	NT	Methyl-accepting chemotaxis protein	pilJ	-	-	ko:K02660	ko02020,ko02025,map02020,map02025	-	-	-	ko00000,ko00001,ko02035,ko02044	-	-	-	MCPsignal,PilJ
HKD3_k127_7313835_3	1163617.SCD_n02922	7.433e-150	508.0	COG0643@1|root,COG0784@1|root,COG2198@1|root,COG0643@2|Bacteria,COG0784@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,2VJSZ@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Histidine kinase	pilL	-	-	ko:K02487,ko:K06596	ko02020,ko02025,map02020,map02025	M00507	-	-	ko00000,ko00001,ko00002,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg
HKD3_k127_7360733_8	1037409.BJ6T_61420	1.341e-25	112.0	COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,2TSG1@28211|Alphaproteobacteria,3JSYZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
HKD3_k127_7360733_6	670292.JH26_25280	1.07e-78	269.0	28NKC@1|root,2ZBM7@2|Bacteria,1MWMY@1224|Proteobacteria,2TU05@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	MA20_08580	-	-	-	-	-	-	-	-	-	-	-	Endostatin
HKD3_k127_7360733_2	243160.BMA2060	1.675e-165	529.0	COG0491@1|root,COG0491@2|Bacteria,1MX4H@1224|Proteobacteria,2VI82@28216|Betaproteobacteria,1K352@119060|Burkholderiaceae	28216|Betaproteobacteria	S	PFAM beta-lactamase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HKD3_k127_7360733_0	1123354.AUDR01000011_gene1465	6.034e-231	728.0	COG0654@1|root,COG0654@2|Bacteria,1MUN4@1224|Proteobacteria,2VI73@28216|Betaproteobacteria	28216|Betaproteobacteria	CH	PFAM monooxygenase FAD-binding	-	-	1.14.13.127	ko:K05712	ko00360,ko01120,ko01220,map00360,map01120,map01220	M00545	R06786,R06787	RC00236	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_3
HKD3_k127_7360733_9	339670.Bamb_0699	4.607e-19	91.0	2E3JP@1|root,32YI0@2|Bacteria,1N6ZI@1224|Proteobacteria,2VWGY@28216|Betaproteobacteria,1KA6J@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Protein of unknown function (DUF2783)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2783
HKD3_k127_7360733_1	267608.RSp0691	6.652e-226	708.0	COG3508@1|root,COG3508@2|Bacteria,1MV9G@1224|Proteobacteria,2VJUH@28216|Betaproteobacteria,1K0PW@119060|Burkholderiaceae	28216|Betaproteobacteria	Q	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate	hmgA	-	1.13.11.5	ko:K00451	ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120	M00044	R02519	RC00737	ko00000,ko00001,ko00002,ko01000	-	-	-	HgmA
HKD3_k127_7360733_3	1217718.ALOU01000028_gene3587	5.988e-112	366.0	COG1024@1|root,COG1024@2|Bacteria,1MWZC@1224|Proteobacteria,2VJVA@28216|Betaproteobacteria,1K0P4@119060|Burkholderiaceae	28216|Betaproteobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	paaF	-	4.2.1.17	ko:K01692,ko:K01715	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01200,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
HKD3_k127_7360733_10	439235.Dalk_1107	1.77e-06	59.0	COG3187@1|root,COG3187@2|Bacteria	2|Bacteria	O	response to heat	-	-	-	ko:K03668,ko:K06079,ko:K09914	ko01503,map01503	-	-	-	ko00000,ko00001	-	-	-	META,NlpE,NlpE_C,YscW
HKD3_k127_7360733_7	204773.HEAR0477	5.102e-45	171.0	COG0778@1|root,COG0778@2|Bacteria,1PKUV@1224|Proteobacteria,2VSFP@28216|Betaproteobacteria,4784P@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	Nitroreductase family	aoxC	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
HKD3_k127_7360733_4	1000565.METUNv1_03362	3.3e-102	353.0	2ESTR@1|root,33KC5@2|Bacteria,1NHBB@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_7360733_5	1500894.JQNN01000001_gene667	8.43e-87	300.0	COG4301@1|root,COG4301@2|Bacteria,1MUCG@1224|Proteobacteria,2VJHK@28216|Betaproteobacteria,473AH@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Histidine-specific methyltransferase, SAM-dependent	egtD	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_33
HKD3_k127_7404373_2	1454004.AW11_03642	3.443e-59	206.0	COG2308@1|root,COG2308@2|Bacteria,1MUAD@1224|Proteobacteria,2VI55@28216|Betaproteobacteria,1KQ7E@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	S	Circularly permuted ATP-grasp type 2	-	-	-	-	-	-	-	-	-	-	-	-	CP_ATPgrasp_2
HKD3_k127_7404373_1	640081.Dsui_3235	7.171e-100	341.0	COG2307@1|root,COG2307@2|Bacteria,1MVZK@1224|Proteobacteria,2VIB5@28216|Betaproteobacteria,2KV8E@206389|Rhodocyclales	206389|Rhodocyclales	S	A predicted alpha-helical domain with a conserved ER motif.	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-E
HKD3_k127_7404373_0	857087.Metme_0558	7.883e-101	334.0	COG3484@1|root,COG3484@2|Bacteria,1N057@1224|Proteobacteria,1RRR0@1236|Gammaproteobacteria,1XE4U@135618|Methylococcales	135618|Methylococcales	O	PFAM 20S proteasome, A and B subunits	-	-	-	ko:K07395	-	-	-	-	ko00000	-	-	-	-
HKD3_k127_7404373_3	883126.HMPREF9710_00168	0.0001682	55.0	COG1305@1|root,COG4196@1|root,COG1305@2|Bacteria,COG4196@2|Bacteria,1MVAG@1224|Proteobacteria,2VKKZ@28216|Betaproteobacteria,472JR@75682|Oxalobacteraceae	28216|Betaproteobacteria	E	Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Bact_transglu_N,DUF2126,Transglut_core
HKD3_k127_7419313_21	1386089.N865_10585	5.675e-65	224.0	COG2931@1|root,COG2931@2|Bacteria	2|Bacteria	Q	calcium- and calmodulin-responsive adenylate cyclase activity	rtxA	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	CBM_2,Calx-beta,DUF4214,HemolysinCabind,SdrD_B
HKD3_k127_7419313_0	1380394.JADL01000009_gene3150	0.0	1098.0	COG0404@1|root,COG0665@1|root,COG0404@2|Bacteria,COG0665@2|Bacteria,1MUXJ@1224|Proteobacteria,2TRGS@28211|Alphaproteobacteria,2JREU@204441|Rhodospirillales	204441|Rhodospirillales	E	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DAO,FAO_M,GCV_T,GCV_T_C
HKD3_k127_7419313_19	1123504.JQKD01000002_gene4029	5.113e-70	248.0	COG0697@1|root,COG0697@2|Bacteria,1R46X@1224|Proteobacteria,2VNGN@28216|Betaproteobacteria,4AJ8R@80864|Comamonadaceae	28216|Betaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HKD3_k127_7419313_2	365046.Rta_31810	6.077e-190	610.0	COG1283@1|root,COG1283@2|Bacteria,1MUDE@1224|Proteobacteria,2VJWM@28216|Betaproteobacteria,4AAPQ@80864|Comamonadaceae	28216|Betaproteobacteria	P	Na Pi-cotransporter II-related protein	nptA	-	-	ko:K03324	-	-	-	-	ko00000,ko02000	2.A.58.2	-	-	Na_Pi_cotrans,PhoU
HKD3_k127_7419313_8	983917.RGE_31510	4.92e-175	560.0	COG0160@1|root,COG0160@2|Bacteria,1QTZ3@1224|Proteobacteria	1224|Proteobacteria	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.19,2.6.1.76	ko:K00823,ko:K00836	ko00250,ko00260,ko00410,ko00640,ko00650,ko01100,ko01120,ko01210,ko01230,map00250,map00260,map00410,map00640,map00650,map01100,map01120,map01210,map01230	M00027,M00033	R00908,R01648,R06977	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
HKD3_k127_7419313_1	1005048.CFU_0638	4.444e-244	762.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2VHGR@28216|Betaproteobacteria,472HD@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	Belongs to the aldehyde dehydrogenase family	-	-	1.2.1.3	ko:K00128	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
HKD3_k127_7419313_5	795666.MW7_1442	8.625e-182	579.0	COG1524@1|root,COG1524@2|Bacteria,1N5SF@1224|Proteobacteria,2VM3U@28216|Betaproteobacteria,1K2Y0@119060|Burkholderiaceae	28216|Betaproteobacteria	S	phosphonoacetate hydrolase	phnA	-	3.11.1.2	ko:K19670	ko00440,map00440	-	R00318	RC01309	ko00000,ko00001,ko01000	-	-	-	Phosphodiest
HKD3_k127_7419313_20	1005048.CFU_0636	4.624e-65	255.0	COG1802@1|root,COG1802@2|Bacteria,1RE3J@1224|Proteobacteria,2VQMY@28216|Betaproteobacteria	28216|Betaproteobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
HKD3_k127_7419313_10	296591.Bpro_4694	2.488e-152	490.0	COG1840@1|root,COG1840@2|Bacteria,1MXZ8@1224|Proteobacteria,2VKTZ@28216|Betaproteobacteria,4AB2I@80864|Comamonadaceae	28216|Betaproteobacteria	P	TIGRFAM 2-aminoethylphosphonate ABC transport system, 1-aminoethylphosphonate-binding protein component	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6
HKD3_k127_7419313_14	1279015.KB908458_gene2561	7.85e-105	353.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,1RMTS@1236|Gammaproteobacteria,1Y5GJ@135624|Aeromonadales	135624|Aeromonadales	E	Belongs to the ABC transporter superfamily	-	-	3.6.3.30	ko:K02010	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.10	-	-	ABC_tran,TOBE_2
HKD3_k127_7419313_6	296591.Bpro_3217	1.208e-177	575.0	COG1178@1|root,COG1178@2|Bacteria,1MXZZ@1224|Proteobacteria,2VI17@28216|Betaproteobacteria,4ACCU@80864|Comamonadaceae	28216|Betaproteobacteria	P	binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02011	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	BPD_transp_1
HKD3_k127_7419313_7	1005048.CFU_0632	2.647e-175	557.0	COG0075@1|root,COG0075@2|Bacteria,1MWHJ@1224|Proteobacteria,2VKXZ@28216|Betaproteobacteria	28216|Betaproteobacteria	E	Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. PhnW subfamily	phnW	-	2.6.1.37	ko:K03430	ko00440,ko01100,ko01120,map00440,map01100,map01120	-	R04152	RC00008,RC00062	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_5
HKD3_k127_7419313_22	1122604.JONR01000068_gene4223	9.543e-60	217.0	COG0494@1|root,COG0494@2|Bacteria,1RAFY@1224|Proteobacteria,1T5SZ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Domain of unknown function (DUF4743)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4743,NUDIX
HKD3_k127_7419313_23	265072.Mfla_0520	9.056e-48	180.0	COG0560@1|root,COG0560@2|Bacteria,1RA1A@1224|Proteobacteria,2VMGV@28216|Betaproteobacteria,2KKU6@206350|Nitrosomonadales	206350|Nitrosomonadales	E	TIGRFAM HAD-superfamily subfamily IB hydrolase, TIGR01490	-	-	-	-	-	-	-	-	-	-	-	-	HAD
HKD3_k127_7419313_13	1049564.TevJSym_ac01720	2.563e-113	389.0	COG0190@1|root,COG0190@2|Bacteria,1MWU4@1224|Proteobacteria,1RNSW@1236|Gammaproteobacteria,1J5I0@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	F	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate	folD	GO:0003674,GO:0003824,GO:0004477,GO:0004486,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0019238,GO:0019752,GO:0034641,GO:0042558,GO:0043436,GO:0043603,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0055114,GO:0071704,GO:1901360,GO:1901564	1.5.1.5,3.5.4.9	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R01220,R01655	RC00202,RC00578	ko00000,ko00001,ko00002,ko01000	-	-	-	THF_DHG_CYH,THF_DHG_CYH_C
HKD3_k127_7419313_16	595537.Varpa_1071	5.375e-86	310.0	COG1177@1|root,COG1177@2|Bacteria,1MUQD@1224|Proteobacteria,2VJ92@28216|Betaproteobacteria,4AD2D@80864|Comamonadaceae	28216|Betaproteobacteria	P	binding-protein-dependent transport systems inner membrane component	potC	-	-	ko:K02053	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	BPD_transp_1
HKD3_k127_7419313_11	269796.Rru_A2046	1.711e-140	458.0	COG1176@1|root,COG1176@2|Bacteria,1MU1Y@1224|Proteobacteria,2TTJ6@28211|Alphaproteobacteria,2JQGS@204441|Rhodospirillales	204441|Rhodospirillales	E	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02054	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	BPD_transp_1
HKD3_k127_7419313_9	595537.Varpa_1073	2.732e-157	521.0	COG0687@1|root,COG0687@2|Bacteria,1MU0I@1224|Proteobacteria,2VICQ@28216|Betaproteobacteria,4AAM0@80864|Comamonadaceae	28216|Betaproteobacteria	E	PFAM extracellular solute-binding protein family 1	-	-	-	ko:K02055	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	SBP_bac_8
HKD3_k127_7419313_12	1121861.KB899914_gene2050	3.992e-134	437.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2TQMJ@28211|Alphaproteobacteria,2JQQC@204441|Rhodospirillales	28211|Alphaproteobacteria	E	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system	-	-	-	ko:K02052	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	ABC_tran,TOBE_2
HKD3_k127_7419313_15	443598.AUFA01000023_gene3317	7.373e-88	298.0	COG1028@1|root,COG1028@2|Bacteria,1MVT2@1224|Proteobacteria,2TQKU@28211|Alphaproteobacteria,3JS01@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	fixR	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HKD3_k127_7419313_4	1123072.AUDH01000003_gene998	2.563e-182	582.0	COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,2TQND@28211|Alphaproteobacteria,2JPGU@204441|Rhodospirillales	204441|Rhodospirillales	H	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.96	ko:K16871	ko00250,ko00650,ko01100,ko01120,map00250,map00650,map01100,map01120	M00027	R10178	RC00008,RC00062	ko00000,ko00001,ko00002,ko01000	-	-	-	Aminotran_3
HKD3_k127_7419313_3	296591.Bpro_4702	1.756e-189	609.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2VK5V@28216|Betaproteobacteria,4AAPR@80864|Comamonadaceae	28216|Betaproteobacteria	C	Aldehyde dehydrogenase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldedh
HKD3_k127_7419313_17	1219031.BBJR01000043_gene1341	1.098e-81	289.0	COG2071@1|root,COG2071@2|Bacteria,1MV8E@1224|Proteobacteria,2VMMI@28216|Betaproteobacteria,4AAN2@80864|Comamonadaceae	28216|Betaproteobacteria	S	Peptidase C26	-	-	4.1.3.27	ko:K01658,ko:K07010	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	Peptidase_C26
HKD3_k127_7419313_18	296591.Bpro_4700	4.556e-71	245.0	COG1454@1|root,COG1454@2|Bacteria,1MVPH@1224|Proteobacteria,2VI90@28216|Betaproteobacteria,4AD0R@80864|Comamonadaceae	28216|Betaproteobacteria	C	Iron-containing alcohol dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Fe-ADH
HKD3_k127_7442640_2	292415.Tbd_1100	2.78e-50	186.0	COG1235@1|root,COG1235@2|Bacteria,1R5N4@1224|Proteobacteria,2VKSE@28216|Betaproteobacteria	28216|Betaproteobacteria	S	PFAM beta-lactamase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
HKD3_k127_7442640_1	1163617.SCD_n01244	1.169e-97	332.0	COG3317@1|root,COG3317@2|Bacteria,1N670@1224|Proteobacteria,2VHS5@28216|Betaproteobacteria	28216|Betaproteobacteria	M	(Lipo)protein	nlpB	-	-	ko:K07287	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	Lipoprotein_18
HKD3_k127_7442640_0	292415.Tbd_1098	1.597e-128	416.0	COG0329@1|root,COG0329@2|Bacteria,1MUCM@1224|Proteobacteria,2VIQ4@28216|Betaproteobacteria,1KS9J@119069|Hydrogenophilales	119069|Hydrogenophilales	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	dapA	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
HKD3_k127_7442640_3	497321.C664_00955	3.378e-36	141.0	COG0500@1|root,COG0500@2|Bacteria,1QU9M@1224|Proteobacteria,2WGK0@28216|Betaproteobacteria,2KWMJ@206389|Rhodocyclales	206389|Rhodocyclales	Q	tellurite resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23,Methyltransf_25
HKD3_k127_7448984_14	1298867.AUES01000011_gene5600	0.0001193	46.0	COG0697@1|root,COG0697@2|Bacteria,1MXX1@1224|Proteobacteria,2TQN0@28211|Alphaproteobacteria,3JTCS@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EG	EamA-like transporter family	MA20_35620	-	-	-	-	-	-	-	-	-	-	-	EamA
HKD3_k127_7448984_9	240016.ABIZ01000001_gene5948	1.639e-83	310.0	COG1052@1|root,COG1052@2|Bacteria,46SAN@74201|Verrucomicrobia	74201|Verrucomicrobia	CH	D-isomer specific 2-hydroxyacid dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	2-Hacid_dh,2-Hacid_dh_C
HKD3_k127_7448984_10	1304883.KI912532_gene1326	1.513e-59	217.0	COG1587@1|root,COG1587@2|Bacteria,1MWZD@1224|Proteobacteria,2VRU9@28216|Betaproteobacteria,2KVD0@206389|Rhodocyclales	206389|Rhodocyclales	H	Uroporphyrinogen-III synthase HemD	hemD	-	4.2.1.75	ko:K01719	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R03165	RC01861	ko00000,ko00001,ko00002,ko01000	-	-	-	HEM4
HKD3_k127_7448984_7	640081.Dsui_1602	1.957e-113	380.0	COG0181@1|root,COG0181@2|Bacteria,1MU56@1224|Proteobacteria,2VHT4@28216|Betaproteobacteria,2KVQ9@206389|Rhodocyclales	206389|Rhodocyclales	H	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps	hemC	-	2.5.1.61	ko:K01749	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00084	RC02317	ko00000,ko00001,ko00002,ko01000	-	-	-	Porphobil_deam,Porphobil_deamC
HKD3_k127_7448984_13	1123393.KB891316_gene1929	6.873e-24	115.0	COG2143@1|root,COG2143@2|Bacteria,1NP6X@1224|Proteobacteria,2WGR9@28216|Betaproteobacteria,1KT3R@119069|Hydrogenophilales	119069|Hydrogenophilales	O	Thioredoxin-like	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_7448984_12	1234364.AMSF01000025_gene3603	8.916e-43	165.0	COG3751@1|root,COG3751@2|Bacteria,1RD3H@1224|Proteobacteria,1S40I@1236|Gammaproteobacteria,1X70N@135614|Xanthomonadales	135614|Xanthomonadales	O	2OG-Fe(II) oxygenase superfamily	-	-	-	ko:K07394	-	-	-	-	ko00000	-	-	-	2OG-FeII_Oxy_3
HKD3_k127_7448984_6	29581.BW37_02380	6.477e-120	393.0	COG0451@1|root,COG0451@2|Bacteria,1MU1A@1224|Proteobacteria,2VHGA@28216|Betaproteobacteria,472GQ@75682|Oxalobacteraceae	28216|Betaproteobacteria	M	Male sterility protein	-	-	1.1.1.410	ko:K22025	-	-	-	-	ko00000,ko01000	-	-	-	Epimerase
HKD3_k127_7448984_4	983917.RGE_26390	7.588e-130	423.0	COG0042@1|root,COG0042@2|Bacteria,1MUY1@1224|Proteobacteria,2VHCA@28216|Betaproteobacteria,1KIVF@119065|unclassified Burkholderiales	28216|Betaproteobacteria	J	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs	dusA	-	-	ko:K05539	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Dus
HKD3_k127_7448984_3	94624.Bpet4766	1.316e-144	486.0	COG1638@1|root,COG1638@2|Bacteria,1MVHC@1224|Proteobacteria,2VHPJ@28216|Betaproteobacteria,3T2W1@506|Alcaligenaceae	28216|Betaproteobacteria	G	C4-dicarboxylate ABC transporter	-	-	-	ko:K11688	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.56.1	-	-	DctP
HKD3_k127_7448984_5	1095769.CAHF01000011_gene2117	1.45e-122	399.0	COG3777@1|root,COG3777@2|Bacteria,1P96N@1224|Proteobacteria,2VIUS@28216|Betaproteobacteria	28216|Betaproteobacteria	S	N-terminal half of MaoC dehydratase	-	-	4.2.1.153,4.2.1.56	ko:K09709,ko:K18291	ko00660,ko00720,ko01120,ko01200,map00660,map00720,map01120,map01200	M00376	R02491,R09282	RC00730,RC02479	ko00000,ko00001,ko00002,ko01000	-	-	-	MaoC_dehydrat_N
HKD3_k127_7448984_0	342113.DM82_901	3.297e-226	707.0	COG1960@1|root,COG1960@2|Bacteria,1MVAH@1224|Proteobacteria,2VKD1@28216|Betaproteobacteria,1JZRA@119060|Burkholderiaceae	28216|Betaproteobacteria	C	acyl-CoA dehydrogenase	acd12	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HKD3_k127_7448984_2	398527.Bphyt_6602	4.912e-191	602.0	COG1804@1|root,COG1804@2|Bacteria,1MU4A@1224|Proteobacteria,2VKDA@28216|Betaproteobacteria,1JZU6@119060|Burkholderiaceae	28216|Betaproteobacteria	C	L-carnitine dehydratase bile acid-inducible protein F	-	-	2.8.3.22	ko:K18289	ko00660,map00660	-	R02407,R03154	RC00014	ko00000,ko00001,ko01000	-	-	-	CoA_transf_3
HKD3_k127_7448984_1	1216976.AX27061_2712	8.77e-198	630.0	COG2079@1|root,COG2079@2|Bacteria,1R5UM@1224|Proteobacteria,2VI2F@28216|Betaproteobacteria,3T1R0@506|Alcaligenaceae	28216|Betaproteobacteria	S	protein involved in propionate catabolism	-	-	-	-	-	-	-	-	-	-	-	-	MmgE_PrpD
HKD3_k127_7448984_11	1454004.AW11_03405	3.132e-57	203.0	COG0500@1|root,COG0500@2|Bacteria,1R0QC@1224|Proteobacteria,2WHV7@28216|Betaproteobacteria	28216|Betaproteobacteria	H	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_7448984_8	883126.HMPREF9710_04222	8.485e-86	305.0	COG2301@1|root,COG2301@2|Bacteria,1MW0A@1224|Proteobacteria,2VMC8@28216|Betaproteobacteria,4776P@75682|Oxalobacteraceae	28216|Betaproteobacteria	G	Belongs to the HpcH HpaI aldolase family	citE	-	4.1.3.24,4.1.3.25,4.1.3.34	ko:K01644,ko:K08691	ko00630,ko00660,ko00680,ko00720,ko01120,ko01200,ko02020,map00630,map00660,map00680,map00720,map01120,map01200,map02020	M00346,M00373,M00376	R00237,R00362,R00473,R00934	RC00067,RC00307,RC00308,RC00311,RC00407,RC00502,RC01118,RC01205	ko00000,ko00001,ko00002,ko01000	-	-	-	HpcH_HpaI
HKD3_k127_7497741_0	1121035.AUCH01000005_gene108	2.928e-212	668.0	COG0280@1|root,COG0281@1|root,COG0280@2|Bacteria,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,2VIYB@28216|Betaproteobacteria,2KVTV@206389|Rhodocyclales	206389|Rhodocyclales	C	Malic enzyme	-	-	1.1.1.40	ko:K00029	ko00620,ko00710,ko01100,ko01120,ko01200,map00620,map00710,map01100,map01120,map01200	M00169,M00172	R00216	RC00105	ko00000,ko00001,ko00002,ko01000	-	-	-	Malic_M,PTA_PTB,malic
HKD3_k127_7497741_4	483219.LILAB_06435	1.772e-27	119.0	COG3871@1|root,COG3871@2|Bacteria,1RF7K@1224|Proteobacteria,431CF@68525|delta/epsilon subdivisions,2WX0W@28221|Deltaproteobacteria,2YYTY@29|Myxococcales	28221|Deltaproteobacteria	S	Pyridoxamine 5'-phosphate oxidase like	-	-	-	-	-	-	-	-	-	-	-	-	Pyrid_ox_like
HKD3_k127_7497741_1	1144342.PMI40_00966	1.783e-142	492.0	COG0715@1|root,COG0715@2|Bacteria,1MW53@1224|Proteobacteria,2VIMG@28216|Betaproteobacteria	28216|Betaproteobacteria	P	ABC-type nitrate sulfonate bicarbonate transport	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
HKD3_k127_7497741_2	864073.HFRIS_001409	4.978e-129	417.0	COG1116@1|root,COG1116@2|Bacteria,1P4HB@1224|Proteobacteria,2VISQ@28216|Betaproteobacteria	28216|Betaproteobacteria	P	ABC-type nitrate sulfonate bicarbonate transport system ATPase component	-	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
HKD3_k127_7497741_3	1166948.JPZL01000002_gene1211	1.551e-118	385.0	COG0600@1|root,COG0600@2|Bacteria,1MVAE@1224|Proteobacteria,1RPEN@1236|Gammaproteobacteria,1XR75@135619|Oceanospirillales	135619|Oceanospirillales	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
HKD3_k127_7522270_3	235909.GK3403	8.912e-33	135.0	COG3278@1|root,COG3278@2|Bacteria,1VAHS@1239|Firmicutes,4HKKG@91061|Bacilli,1WGKE@129337|Geobacillus	91061|Bacilli	O	COG3278 Cbb3-type cytochrome oxidase, subunit 1	-	-	-	-	-	-	-	-	-	-	-	-	COX1
HKD3_k127_7522270_6	1207076.ALAT01000204_gene1781	1.256e-18	92.0	2C7M1@1|root,33I9V@2|Bacteria,1NNVG@1224|Proteobacteria,1SSTU@1236|Gammaproteobacteria,1Z2YU@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF1992
HKD3_k127_7522270_4	1210884.HG799463_gene9611	8.955e-23	111.0	COG0454@1|root,COG0456@2|Bacteria,2J1HM@203682|Planctomycetes	203682|Planctomycetes	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HKD3_k127_7522270_5	292.DM42_6039	4.529e-20	102.0	2EIDG@1|root,33C4V@2|Bacteria,1N0P4@1224|Proteobacteria,2VYCP@28216|Betaproteobacteria,1K9BA@119060|Burkholderiaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_7522270_2	85643.Tmz1t_0743	3.297e-66	231.0	2DKA3@1|root,30905@2|Bacteria,1RGG6@1224|Proteobacteria	1224|Proteobacteria	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_2
HKD3_k127_7522270_0	1396418.BATQ01000184_gene2632	1.141e-172	573.0	COG2114@1|root,COG3903@1|root,COG2114@2|Bacteria,COG3903@2|Bacteria,46TZ3@74201|Verrucomicrobia	74201|Verrucomicrobia	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,NB-ARC
HKD3_k127_7522270_1	296591.Bpro_3893	7.188e-114	377.0	COG2304@1|root,COG2304@2|Bacteria,1MXQ7@1224|Proteobacteria,2VHRY@28216|Betaproteobacteria,4ACKS@80864|Comamonadaceae	28216|Betaproteobacteria	S	von Willebrand factor, type A	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	BatA,VWA
HKD3_k127_753283_30	1123393.KB891332_gene2763	8.32e-17	83.0	COG0223@1|root,COG0223@2|Bacteria,1MU4Q@1224|Proteobacteria,2VIS2@28216|Betaproteobacteria,1KS9N@119069|Hydrogenophilales	119069|Hydrogenophilales	J	Formyl transferase, C-terminal domain	-	-	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	-	Formyl_trans_C,Formyl_trans_N
HKD3_k127_753283_9	1120999.JONM01000013_gene2143	6.191e-119	400.0	COG0144@1|root,COG0144@2|Bacteria,1MWPE@1224|Proteobacteria,2VI4V@28216|Betaproteobacteria,2KQCQ@206351|Neisseriales	206351|Neisseriales	J	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA	sun	-	2.1.1.176	ko:K03500	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltr_RsmB-F,NusB
HKD3_k127_753283_27	1000565.METUNv1_03067	1.434e-37	162.0	29CX4@1|root,2ZZV8@2|Bacteria,1RFY7@1224|Proteobacteria,2VR98@28216|Betaproteobacteria,2KWGK@206389|Rhodocyclales	206389|Rhodocyclales	S	Domain of unknown function (DUF4390)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4390
HKD3_k127_753283_4	1163617.SCD_n00013	4.033e-191	628.0	COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,2VIDI@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Histidine kinase	ntrY	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS_4,PAS_7,PAS_8
HKD3_k127_753283_11	153948.NAL212_2985	2.694e-111	374.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VKD8@28216|Betaproteobacteria,3721F@32003|Nitrosomonadales	28216|Betaproteobacteria	T	Sigma-54 interaction domain	ntrX	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activ_2
HKD3_k127_753283_0	1163617.SCD_n00015	2.702e-244	769.0	COG3158@1|root,COG3158@2|Bacteria,1MUVH@1224|Proteobacteria,2VH9I@28216|Betaproteobacteria	28216|Betaproteobacteria	P	Transport of potassium into the cell	kup	-	-	ko:K03549	-	-	-	-	ko00000,ko02000	2.A.72	-	-	K_trans
HKD3_k127_753283_13	497321.C664_18242	3.561e-107	356.0	COG0568@1|root,COG0568@2|Bacteria,1MVWR@1224|Proteobacteria,2VI91@28216|Betaproteobacteria,2KUT2@206389|Rhodocyclales	206389|Rhodocyclales	K	RNA polymerase sigma	rpoH	-	-	ko:K03089	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r4
HKD3_k127_753283_8	1000565.METUNv1_03797	1.99e-121	403.0	COG0552@1|root,COG0552@2|Bacteria,1MUDU@1224|Proteobacteria,2VHK7@28216|Betaproteobacteria,2KVC3@206389|Rhodocyclales	206389|Rhodocyclales	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components	ftsY	-	-	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2,3.A.5.7	-	-	SRP54,SRP54_N
HKD3_k127_753283_25	395494.Galf_0464	8.144e-45	169.0	COG0742@1|root,COG0742@2|Bacteria,1MXKW@1224|Proteobacteria,2VRD3@28216|Betaproteobacteria,44VUP@713636|Nitrosomonadales	28216|Betaproteobacteria	L	Conserved hypothetical protein 95	rsmD	-	2.1.1.171	ko:K08316	-	-	R07234	RC00003	ko00000,ko01000,ko03009	-	-	-	Cons_hypoth95
HKD3_k127_753283_19	640081.Dsui_1028	6.966e-63	227.0	COG0669@1|root,COG0669@2|Bacteria,1RD9F@1224|Proteobacteria,2VMQQ@28216|Betaproteobacteria,2KW7T@206389|Rhodocyclales	206389|Rhodocyclales	H	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate	coaD	-	2.7.7.3	ko:K00954	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
HKD3_k127_753283_26	754476.Q7A_1273	2.321e-38	148.0	COG1145@1|root,COG1145@2|Bacteria,1MZ6H@1224|Proteobacteria,1S8ZV@1236|Gammaproteobacteria,460XB@72273|Thiotrichales	72273|Thiotrichales	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
HKD3_k127_753283_7	1005048.CFU_3656	1.139e-129	425.0	COG0683@1|root,COG0683@2|Bacteria,1MWR8@1224|Proteobacteria,2VHH6@28216|Betaproteobacteria,476W0@75682|Oxalobacteraceae	28216|Betaproteobacteria	E	Receptor family ligand binding region	-	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_6
HKD3_k127_753283_1	1163617.SCD_n02632	1.006e-223	711.0	COG0699@1|root,COG0699@2|Bacteria,1MXBK@1224|Proteobacteria,2VKA1@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Dynamin family	-	-	-	-	-	-	-	-	-	-	-	-	Dynamin_N
HKD3_k127_753283_14	1120999.JONM01000010_gene4104	7.749e-94	316.0	COG0266@1|root,COG0266@2|Bacteria,1MVM5@1224|Proteobacteria,2VI10@28216|Betaproteobacteria,2KQ88@206351|Neisseriales	206351|Neisseriales	L	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates	mutM	-	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
HKD3_k127_753283_12	1163617.SCD_n02625	1.296e-109	376.0	COG0457@1|root,COG0457@2|Bacteria,1MYB8@1224|Proteobacteria,2VI6C@28216|Betaproteobacteria	28216|Betaproteobacteria	H	SMART Tetratricopeptide domain protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_19,TPR_8
HKD3_k127_753283_28	580332.Slit_2356	2.973e-28	121.0	COG3017@1|root,COG3017@2|Bacteria,1N02T@1224|Proteobacteria,2VUIR@28216|Betaproteobacteria	28216|Betaproteobacteria	M	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein	lolB	-	-	ko:K02494	-	-	-	-	ko00000	-	-	-	LolB
HKD3_k127_753283_17	292415.Tbd_0386	2.219e-80	277.0	COG1947@1|root,COG1947@2|Bacteria,1MVU3@1224|Proteobacteria,2VHK3@28216|Betaproteobacteria,1KRYI@119069|Hydrogenophilales	119069|Hydrogenophilales	I	GHMP kinases N terminal domain	-	-	2.7.1.148	ko:K00919	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05634	RC00002,RC01439	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
HKD3_k127_753283_6	1163617.SCD_n02621	1.562e-158	504.0	COG0462@1|root,COG0462@2|Bacteria,1MW21@1224|Proteobacteria,2VHU0@28216|Betaproteobacteria	28216|Betaproteobacteria	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	prs	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyl_synth,Pribosyltran_N
HKD3_k127_753283_16	1156919.QWC_13547	1.235e-89	304.0	COG1028@1|root,COG1028@2|Bacteria,1QIZD@1224|Proteobacteria,2VNCS@28216|Betaproteobacteria	28216|Betaproteobacteria	IQ	PFAM Short-chain dehydrogenase reductase SDR	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HKD3_k127_753283_18	85643.Tmz1t_3628	1.635e-67	241.0	COG1825@1|root,COG1825@2|Bacteria,1RDH0@1224|Proteobacteria,2VQNU@28216|Betaproteobacteria,2KV6M@206389|Rhodocyclales	206389|Rhodocyclales	J	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance	ctc	-	-	ko:K02897	ko03010,map03010	M00178	-	-	ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L25p,Ribosomal_TL5_C
HKD3_k127_753283_22	1286093.C266_05224	1.484e-61	222.0	COG0193@1|root,COG0193@2|Bacteria,1MX1P@1224|Proteobacteria,2VKKJ@28216|Betaproteobacteria,1K2H3@119060|Burkholderiaceae	28216|Betaproteobacteria	J	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis	pth	-	3.1.1.29	ko:K01056	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	Pept_tRNA_hydro
HKD3_k127_753283_5	1038869.AXAN01000055_gene425	5.069e-171	550.0	COG0012@1|root,COG0012@2|Bacteria,1MVM4@1224|Proteobacteria,2VJ1W@28216|Betaproteobacteria,1K3VB@119060|Burkholderiaceae	28216|Betaproteobacteria	J	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner	ychF	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,YchF-GTPase_C
HKD3_k127_753283_32	292415.Tbd_0149	1.795e-05	57.0	COG5608@1|root,COG5608@2|Bacteria	2|Bacteria	S	Late embryogenesis abundant protein	-	-	-	-	-	-	-	-	-	-	-	-	LEA_2
HKD3_k127_753283_10	1121035.AUCH01000012_gene2966	8.99e-119	395.0	COG0253@1|root,COG0253@2|Bacteria,1MWDH@1224|Proteobacteria,2VI0C@28216|Betaproteobacteria,2KV20@206389|Rhodocyclales	206389|Rhodocyclales	E	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan	dapF	-	5.1.1.7	ko:K01778	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00527	R02735	RC00302	ko00000,ko00001,ko00002,ko01000	-	-	-	DAP_epimerase
HKD3_k127_753283_23	1163617.SCD_n00312	2.864e-58	211.0	COG3159@1|root,COG3159@2|Bacteria,1R4BP@1224|Proteobacteria,2VPN6@28216|Betaproteobacteria	28216|Betaproteobacteria	S	protein conserved in bacteria	-	-	-	ko:K09921	-	-	-	-	ko00000	-	-	-	DUF484
HKD3_k127_753283_15	582744.Msip34_0172	1.377e-92	324.0	COG4973@1|root,COG4973@2|Bacteria,1MUJJ@1224|Proteobacteria,2VJ5V@28216|Betaproteobacteria,2KKM7@206350|Nitrosomonadales	206350|Nitrosomonadales	L	Belongs to the 'phage' integrase family. XerC subfamily	xerC	-	-	ko:K03733	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
HKD3_k127_753283_21	1173025.GEI7407_2260	8.227e-62	217.0	COG2318@1|root,COG2318@2|Bacteria,1G5EJ@1117|Cyanobacteria,1HAJ9@1150|Oscillatoriales	1117|Cyanobacteria	S	PFAM DinB family	-	-	-	-	-	-	-	-	-	-	-	-	DinB
HKD3_k127_753283_2	1123073.KB899241_gene2530	7.045e-222	704.0	COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,1RNKF@1236|Gammaproteobacteria,1X39P@135614|Xanthomonadales	135614|Xanthomonadales	P	Ammonium transporter	amtB	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
HKD3_k127_753283_24	62928.azo3739	3.441e-58	205.0	COG0347@1|root,COG0347@2|Bacteria,1RGWK@1224|Proteobacteria,2VSEZ@28216|Betaproteobacteria,2KWCQ@206389|Rhodocyclales	206389|Rhodocyclales	K	Belongs to the P(II) protein family	glnK	-	-	ko:K04752	-	-	-	-	ko00000	-	-	-	P-II
HKD3_k127_753283_20	1000565.METUNv1_03322	1.195e-62	226.0	2C5U9@1|root,30FF7@2|Bacteria,1N2U0@1224|Proteobacteria,2VSBN@28216|Betaproteobacteria,2KWHS@206389|Rhodocyclales	206389|Rhodocyclales	S	Bacterial protein of unknown function (Gcw_chp)	-	-	-	-	-	-	-	-	-	-	-	-	Gcw_chp
HKD3_k127_753283_29	395494.Galf_0068	3.454e-22	98.0	COG2960@1|root,COG2960@2|Bacteria,1N7AH@1224|Proteobacteria,2VVR4@28216|Betaproteobacteria,44W3N@713636|Nitrosomonadales	28216|Betaproteobacteria	S	Membrane fusogenic activity	yqiC	-	-	ko:K09806	-	-	-	-	ko00000	-	-	-	BMFP
HKD3_k127_753283_3	522306.CAP2UW1_0748	4.746e-192	614.0	COG0606@1|root,COG0606@2|Bacteria,1MU4R@1224|Proteobacteria,2VHRV@28216|Betaproteobacteria,1KQFP@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	O	Magnesium chelatase, subunit ChlI	comM	-	-	ko:K07391	-	-	-	-	ko00000	-	-	-	ChlI,Mg_chelatase,Mg_chelatase_C
HKD3_k127_753283_31	713587.THITH_10385	1.631e-10	65.0	COG0838@1|root,COG0838@2|Bacteria	2|Bacteria	C	NADH dehydrogenase (ubiquinone) activity	nuoA	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0044425,GO:0050136,GO:0055114,GO:0098796,GO:1902494	1.6.5.3	ko:K00330	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q4
HKD3_k127_757905_2	1307759.JOMJ01000004_gene2582	8.457e-12	69.0	COG0134@1|root,COG0134@2|Bacteria,1MW5K@1224|Proteobacteria,42MAG@68525|delta/epsilon subdivisions,2WM94@28221|Deltaproteobacteria,2M9ZB@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	Belongs to the TrpC family	trpC	-	4.1.1.48,5.3.1.24	ko:K01609,ko:K13498	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03508,R03509	RC00944,RC00945	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2494	IGPS
HKD3_k127_757905_1	1068978.AMETH_4371	5.162e-29	126.0	COG0135@1|root,COG0135@2|Bacteria,2IHPP@201174|Actinobacteria,4E306@85010|Pseudonocardiales	201174|Actinobacteria	E	N-(5'phosphoribosyl)anthranilate (PRA) isomerase	trpF	-	5.3.1.24	ko:K01817	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03509	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	PRAI
HKD3_k127_757905_0	379066.GAU_1723	1.812e-87	295.0	COG0133@1|root,COG0133@2|Bacteria,1ZSUM@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB	-	4.2.1.20	ko:K01696	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HKD3_k127_7669027_2	398767.Glov_1803	2.458e-06	54.0	COG3303@1|root,COG3303@2|Bacteria,1QX6Q@1224|Proteobacteria,42MHA@68525|delta/epsilon subdivisions,2WMF3@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	Cytochrome c554 and c-prime	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C552,Cytochrome_C554,Paired_CXXCH_1
HKD3_k127_7669027_1	1221522.B723_01045	2.408e-36	147.0	COG1695@1|root,COG1695@2|Bacteria,1RHG3@1224|Proteobacteria	1224|Proteobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	PadR
HKD3_k127_7669027_0	395961.Cyan7425_1449	3.542e-159	507.0	COG3119@1|root,COG3119@2|Bacteria,1G3EC@1117|Cyanobacteria,3KGWJ@43988|Cyanothece	1117|Cyanobacteria	P	Sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase,Sulfatase_C
HKD3_k127_76720_1	522306.CAP2UW1_3278	4.738e-145	477.0	COG0451@1|root,COG0451@2|Bacteria,1MU7J@1224|Proteobacteria,2VI0M@28216|Betaproteobacteria,1KR3Y@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	M	Male sterility protein	wbpP	-	5.1.3.7	ko:K02473	ko00520,ko01100,map00520,map01100	-	R00418	RC00289	ko00000,ko00001,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
HKD3_k127_76720_0	395495.Lcho_3069	1.552e-211	666.0	COG0677@1|root,COG0677@2|Bacteria,1MUC6@1224|Proteobacteria,2VJ7A@28216|Betaproteobacteria,1KK08@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	-	-	-	ko:K02474	ko00520,map00520	-	R06894	RC00291	ko00000,ko00001,ko01000,ko01005	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
HKD3_k127_76720_2	522306.CAP2UW1_2041	1.292e-54	201.0	COG0457@1|root,COG3063@1|root,COG0457@2|Bacteria,COG3063@2|Bacteria,1MXMD@1224|Proteobacteria,2VIMP@28216|Betaproteobacteria	28216|Betaproteobacteria	O	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_19,TPR_2,TPR_6,TPR_8
HKD3_k127_7679144_10	627192.SLG_02620	1.158e-67	236.0	COG0620@1|root,COG0620@2|Bacteria,1MV2Z@1224|Proteobacteria,2TSRH@28211|Alphaproteobacteria,2K9SZ@204457|Sphingomonadales	204457|Sphingomonadales	E	Cobalamin-independent synthase, Catalytic domain	-	-	2.1.1.14	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R04405,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Meth_synt_2
HKD3_k127_7679144_7	1238182.C882_2963	9.114e-92	316.0	COG0477@1|root,COG2814@2|Bacteria,1MW19@1224|Proteobacteria,2TRQD@28211|Alphaproteobacteria,2JZMC@204441|Rhodospirillales	204441|Rhodospirillales	EGP	Sugar (and other) transporter	-	-	-	ko:K07552	-	-	-	-	ko00000,ko02000	2.A.1.2	-	-	MFS_1
HKD3_k127_7679144_8	987059.RBXJA2T_17731	4.836e-89	303.0	COG2979@1|root,COG2979@2|Bacteria,1R221@1224|Proteobacteria,2WI84@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Protein of unknown function (DUF533)	-	-	-	-	-	-	-	-	-	-	-	-	DUF533
HKD3_k127_7679144_2	1492922.GY26_10300	1.989e-170	544.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,1RNB5@1236|Gammaproteobacteria,1J4ZP@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	acyl-CoA transferases carnitine dehydratase	-	-	2.8.3.16	ko:K07749	-	-	-	-	ko00000,ko01000	-	-	-	CoA_transf_3
HKD3_k127_7679144_15	296591.Bpro_4881	5.148e-38	149.0	COG3090@1|root,COG3090@2|Bacteria,1RAZ5@1224|Proteobacteria,2VQ8J@28216|Betaproteobacteria,4ADJZ@80864|Comamonadaceae	28216|Betaproteobacteria	G	Tripartite ATP-independent periplasmic transporter, DctQ	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
HKD3_k127_7679144_5	595537.Varpa_2336	2.445e-144	482.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2VHJP@28216|Betaproteobacteria,4ACPD@80864|Comamonadaceae	28216|Betaproteobacteria	G	Trap dicarboxylate transporter, dctm subunit	-	-	-	-	-	-	-	-	-	-	-	-	DctM
HKD3_k127_7679144_4	1123504.JQKD01000040_gene2795	6.467e-151	487.0	COG1638@1|root,COG1638@2|Bacteria,1MVHC@1224|Proteobacteria,2VM68@28216|Betaproteobacteria,4AA1S@80864|Comamonadaceae	28216|Betaproteobacteria	G	TIGRFAM TRAP dicarboxylate transporter, DctP subunit	yiaO	-	-	-	-	-	-	-	-	-	-	-	DctP
HKD3_k127_7679144_0	76114.ebA4490	3.772e-219	691.0	COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2VH8M@28216|Betaproteobacteria,2KUI1@206389|Rhodocyclales	206389|Rhodocyclales	C	Glycolate oxidase subunit GlcD	glcD	-	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
HKD3_k127_7679144_1	1157708.KB907454_gene3046	1.837e-191	608.0	COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2VI85@28216|Betaproteobacteria,4AAZB@80864|Comamonadaceae	28216|Betaproteobacteria	C	PFAM FAD linked oxidase domain protein	dldH	-	1.1.2.4,1.1.5.12	ko:K00102,ko:K03777	ko00620,ko01120,map00620,map01120	-	R00197,R00704,R11591	RC00044	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
HKD3_k127_7679144_11	62928.azo0494	3.85e-64	229.0	COG0625@1|root,COG0625@2|Bacteria,1PHM1@1224|Proteobacteria,2VI65@28216|Betaproteobacteria,2KW9Y@206389|Rhodocyclales	206389|Rhodocyclales	O	Glutathione S-transferase	-	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C_2,GST_N_3
HKD3_k127_7679144_6	1502852.FG94_02032	3.133e-126	414.0	COG0277@1|root,COG0277@2|Bacteria,1MVYV@1224|Proteobacteria,2VHUQ@28216|Betaproteobacteria,4725H@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	FAD binding domain	glcE	-	-	ko:K11472	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	FAD_binding_4
HKD3_k127_7679144_3	76114.ebA4492	1.222e-162	539.0	COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,2VISA@28216|Betaproteobacteria,2KUHR@206389|Rhodocyclales	206389|Rhodocyclales	C	glycolate oxidase iron-sulfur subunit	glcF	-	-	ko:K11473	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	CCG,Fer4_7
HKD3_k127_7679144_14	640511.BC1002_2055	1.78e-51	193.0	COG0824@1|root,COG0824@2|Bacteria,1RGZN@1224|Proteobacteria,2VREZ@28216|Betaproteobacteria,1K703@119060|Burkholderiaceae	28216|Betaproteobacteria	S	PFAM thioesterase superfamily protein	-	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT,4HBT_2
HKD3_k127_7679144_16	1173020.Cha6605_2960	1.687e-36	150.0	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10
HKD3_k127_7679144_13	1123392.AQWL01000003_gene516	1.195e-58	213.0	COG1211@1|root,COG1211@2|Bacteria,1MY3B@1224|Proteobacteria,2VMD6@28216|Betaproteobacteria,1KSNG@119069|Hydrogenophilales	119069|Hydrogenophilales	I	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	-	-	2.7.7.60	ko:K00991	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	IspD
HKD3_k127_7679144_12	1123393.KB891329_gene1058	3.027e-60	212.0	COG0245@1|root,COG0245@2|Bacteria,1MVHA@1224|Proteobacteria,2VR7F@28216|Betaproteobacteria,1KRPQ@119069|Hydrogenophilales	119069|Hydrogenophilales	I	YgbB family	-	-	4.6.1.12	ko:K01770	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05637	RC00002,RC01440	ko00000,ko00001,ko00002,ko01000	-	-	-	YgbB
HKD3_k127_7679144_9	159087.Daro_1979	2.359e-70	248.0	COG0642@1|root,COG5000@1|root,COG2205@2|Bacteria,COG5000@2|Bacteria,1MUAK@1224|Proteobacteria,2VJ6W@28216|Betaproteobacteria,2KUEB@206389|Rhodocyclales	206389|Rhodocyclales	T	Periplasmic domain of Sensor histidine kinase RisS	-	-	2.7.13.3	ko:K07638	ko02020,ko02026,map02020,map02026	M00445,M00742,M00743	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,RisS_PPD
HKD3_k127_7708472_22	522306.CAP2UW1_2866	1.23e-33	135.0	COG0764@1|root,COG0764@2|Bacteria,1RH2T@1224|Proteobacteria,2VRKQ@28216|Betaproteobacteria,1KQ0V@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	I	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs	fabZ	-	4.2.1.59	ko:K02372	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07764,R10117,R10121	RC00831,RC01095	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FabA
HKD3_k127_7708472_9	1304883.KI912532_gene3016	8.166e-108	359.0	COG2935@1|root,COG2935@2|Bacteria,1MW62@1224|Proteobacteria,2VJ8E@28216|Betaproteobacteria,2KVBA@206389|Rhodocyclales	206389|Rhodocyclales	O	May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate	ate	-	2.3.2.29	ko:K21420	-	-	R11547,R11548	RC00064	ko00000,ko01000	-	-	-	ATE_C,ATE_N
HKD3_k127_7708472_13	1163617.SCD_n01859	1.194e-84	286.0	COG2360@1|root,COG2360@2|Bacteria,1R9W8@1224|Proteobacteria,2VIUV@28216|Betaproteobacteria	28216|Betaproteobacteria	O	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine	aat	-	2.3.2.6	ko:K00684	-	-	R03813,R11443,R11444	RC00055,RC00064	ko00000,ko01000	-	-	-	Leu_Phe_trans
HKD3_k127_7708472_15	1255043.TVNIR_0889	8.656e-81	287.0	COG2199@1|root,COG2703@1|root,COG2703@2|Bacteria,COG3706@2|Bacteria,1MZV7@1224|Proteobacteria,1S5H1@1236|Gammaproteobacteria,1X16Q@135613|Chromatiales	135613|Chromatiales	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
HKD3_k127_7708472_24	1121875.KB907547_gene3443	1.623e-21	99.0	2BWYK@1|root,32R5D@2|Bacteria,4NS4D@976|Bacteroidetes	976|Bacteroidetes	T	PAS domain	-	-	-	-	-	-	-	-	-	-	-	-	PAS_4,PAS_8
HKD3_k127_7708472_11	388413.ALPR1_05140	9.242e-89	300.0	COG1235@1|root,COG1235@2|Bacteria,4NM16@976|Bacteroidetes,47U32@768503|Cytophagia	976|Bacteroidetes	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
HKD3_k127_7708472_8	439235.Dalk_2094	8.32e-119	410.0	COG0664@1|root,COG1752@1|root,COG0664@2|Bacteria,COG1752@2|Bacteria,1MUM9@1224|Proteobacteria,42RSN@68525|delta/epsilon subdivisions,2WNDI@28221|Deltaproteobacteria,2MPUY@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Patatin-like phospholipase	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin,cNMP_binding
HKD3_k127_7708472_1	1123368.AUIS01000001_gene2024	7.988e-215	684.0	COG3975@1|root,COG3975@2|Bacteria,1MUHZ@1224|Proteobacteria,1RR50@1236|Gammaproteobacteria,2NC0C@225057|Acidithiobacillales	225057|Acidithiobacillales	S	M61 glycyl aminopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Peptidase_M61
HKD3_k127_7708472_7	1267533.KB906740_gene284	7.851e-168	563.0	COG1505@1|root,COG1505@2|Bacteria,3Y2UH@57723|Acidobacteria,2JHQ3@204432|Acidobacteriia	204432|Acidobacteriia	E	Prolyl oligopeptidase, N-terminal beta-propeller domain	-	-	3.4.21.26	ko:K01322	ko04614,map04614	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S9,Peptidase_S9_N
HKD3_k127_7708472_12	1392838.AWNM01000070_gene1181	1.679e-87	302.0	COG1881@1|root,COG1881@2|Bacteria,1N0Y4@1224|Proteobacteria,2VJ4C@28216|Betaproteobacteria,3T2J4@506|Alcaligenaceae	28216|Betaproteobacteria	S	Phospholipid-binding protein	ybhB	-	-	ko:K06910	-	-	-	-	ko00000	-	-	-	PBP
HKD3_k127_7708472_19	1380391.JIAS01000013_gene3694	7.327e-56	222.0	COG0625@1|root,COG0625@2|Bacteria,1RA4Y@1224|Proteobacteria,2U5B6@28211|Alphaproteobacteria,2JRTT@204441|Rhodospirillales	204441|Rhodospirillales	O	maleylacetoacetate isomerase	-	-	-	-	-	-	-	-	-	-	-	-	GST_N_3
HKD3_k127_7708472_27	522306.CAP2UW1_1619	5.045e-08	60.0	2EDY7@1|root,337T3@2|Bacteria,1RKSZ@1224|Proteobacteria,2VTSJ@28216|Betaproteobacteria,1KR4N@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_7708472_6	1001585.MDS_1256	3.541e-171	549.0	COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,1RQX2@1236|Gammaproteobacteria,1YFCW@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	C	FAD linked oxidases, C-terminal domain	-	-	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
HKD3_k127_7708472_26	257313.BP0077	1.414e-09	65.0	2EHK0@1|root,33BBV@2|Bacteria,1NGIK@1224|Proteobacteria,2VXN8@28216|Betaproteobacteria,3T4XJ@506|Alcaligenaceae	28216|Betaproteobacteria	-	-	-	-	-	ko:K06950	-	-	-	-	ko00000	-	-	-	-
HKD3_k127_7708472_10	1163617.SCD_n02102	5.51e-103	355.0	COG3852@1|root,COG3852@2|Bacteria,1QVPN@1224|Proteobacteria,2WH69@28216|Betaproteobacteria	28216|Betaproteobacteria	T	ATPase histidine kinase DNA gyrase B HSP90 domain protein	pilS	-	2.7.13.3	ko:K02668	ko02020,map02020	M00501	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	HATPase_c,HisKA
HKD3_k127_7708472_4	243365.CV_0073	9.289e-177	564.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VHSB@28216|Betaproteobacteria,2KPJ5@206351|Neisseriales	206351|Neisseriales	T	Sigma-54 interaction domain protein	pilR	-	-	ko:K02667	ko02020,map02020	M00501	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD3_k127_7708472_17	1123392.AQWL01000004_gene2546	1.393e-75	263.0	COG3023@1|root,COG3023@2|Bacteria,1RDHU@1224|Proteobacteria,2VR5A@28216|Betaproteobacteria,1KRM8@119069|Hydrogenophilales	119069|Hydrogenophilales	V	Ami_2	-	-	3.5.1.28	ko:K03806	-	-	-	-	ko00000,ko01000,ko01011	-	-	-	Amidase_2
HKD3_k127_7708472_18	640081.Dsui_2886	2.811e-57	204.0	COG2917@1|root,COG2917@2|Bacteria,1NWIZ@1224|Proteobacteria,2VRHB@28216|Betaproteobacteria,2KVFB@206389|Rhodocyclales	206389|Rhodocyclales	D	probably involved in intracellular septation	ispZ	-	-	ko:K06190	-	-	-	-	ko00000	-	-	-	IspA
HKD3_k127_7708472_25	1120999.JONM01000001_gene1264	1.035e-19	99.0	COG0271@1|root,COG0271@2|Bacteria,1MZG5@1224|Proteobacteria,2VVNP@28216|Betaproteobacteria,2KRYY@206351|Neisseriales	206351|Neisseriales	T	Belongs to the BolA IbaG family	bolA	-	-	ko:K05527	-	-	-	-	ko00000,ko03000	-	-	-	BolA
HKD3_k127_7708472_16	62928.azo1703	2.678e-76	269.0	COG0760@1|root,COG0760@2|Bacteria,1MZDK@1224|Proteobacteria,2VJZP@28216|Betaproteobacteria,2KVE7@206389|Rhodocyclales	206389|Rhodocyclales	M	peptidylprolyl isomerase	-	-	5.2.1.8	ko:K03769	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase_3
HKD3_k127_7708472_5	1122185.N792_08240	1.17e-175	564.0	COG0364@1|root,COG0364@2|Bacteria,1MUN0@1224|Proteobacteria,1RQE4@1236|Gammaproteobacteria,1X59Z@135614|Xanthomonadales	135614|Xanthomonadales	G	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone	-	-	1.1.1.363,1.1.1.49	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	M00004,M00006,M00008	R00835,R02736,R10907	RC00001,RC00066	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	G6PD_C,G6PD_N
HKD3_k127_7708472_21	1110502.TMO_0530	1.764e-49	183.0	COG1309@1|root,COG1309@2|Bacteria,1N2QP@1224|Proteobacteria,2UD2J@28211|Alphaproteobacteria,2JX7S@204441|Rhodospirillales	204441|Rhodospirillales	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
HKD3_k127_7708472_20	1354722.JQLS01000004_gene4224	1.226e-49	181.0	COG2185@1|root,COG2185@2|Bacteria,1NVW6@1224|Proteobacteria,2US8B@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	B12 binding domain	-	GO:0003674,GO:0003824,GO:0005488,GO:0006139,GO:0006163,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009117,GO:0009150,GO:0009259,GO:0009987,GO:0016853,GO:0016866,GO:0019637,GO:0019693,GO:0019842,GO:0031419,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0034784,GO:0035383,GO:0036094,GO:0043603,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0046906,GO:0048037,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:0097159,GO:1901135,GO:1901360,GO:1901363,GO:1901564	5.4.99.2	ko:K01849	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding
HKD3_k127_7708472_0	78245.Xaut_5043	3.898e-233	735.0	COG1884@1|root,COG1884@2|Bacteria,1NQI2@1224|Proteobacteria,2UP9V@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Methylmalonyl-CoA mutase	-	GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009150,GO:0009259,GO:0009987,GO:0016853,GO:0016866,GO:0019637,GO:0019693,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0034784,GO:0035383,GO:0043603,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564	5.4.99.2	ko:K01848	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	MM_CoA_mutase
HKD3_k127_7708472_14	76114.ebA2092	1.023e-82	293.0	COG1703@1|root,COG1975@1|root,COG1703@2|Bacteria,COG1975@2|Bacteria,1MVI0@1224|Proteobacteria,2VIRF@28216|Betaproteobacteria,2KVDF@206389|Rhodocyclales	28216|Betaproteobacteria	E	periplasmic protein kinase ArgK and related GTPases of G3E family	-	-	-	ko:K07588	-	-	-	-	ko00000,ko01000	-	-	-	ArgK
HKD3_k127_7708472_3	649638.Trad_2420	8.706e-196	626.0	COG0405@1|root,COG0405@2|Bacteria,1WI9V@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	PFAM Gamma-glutamyltranspeptidase	-	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
HKD3_k127_7708472_2	1123393.KB891332_gene2710	2.767e-202	645.0	COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,2VH3Q@28216|Betaproteobacteria,1KSBS@119069|Hydrogenophilales	119069|Hydrogenophilales	F	Ribonucleotide reductase, barrel domain	-	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_lgC,Ribonuc_red_lgN
HKD3_k127_7708472_23	85643.Tmz1t_1515	2.801e-27	113.0	COG0663@1|root,COG0663@2|Bacteria,1MVUI@1224|Proteobacteria,2VH4Y@28216|Betaproteobacteria,2KUST@206389|Rhodocyclales	206389|Rhodocyclales	S	Phenylacetic acid degradation protein PaaY	-	-	-	ko:K02617	-	-	-	-	ko00000	-	-	-	Hexapep
HKD3_k127_7727798_2	292415.Tbd_0231	1.052e-11	66.0	COG3279@1|root,COG3279@2|Bacteria,1MUE8@1224|Proteobacteria,2WEFP@28216|Betaproteobacteria	28216|Betaproteobacteria	KT	response regulator	algR	-	-	ko:K08083	ko02020,map02020	M00493	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	LytTR,Response_reg
HKD3_k127_7727798_1	1095769.CAHF01000011_gene2611	1.32e-61	227.0	COG2972@1|root,COG2972@2|Bacteria,1MXVQ@1224|Proteobacteria,2VH9S@28216|Betaproteobacteria,473HB@75682|Oxalobacteraceae	28216|Betaproteobacteria	T	Histidine kinase	algZ	-	2.7.13.3	ko:K08082	ko02020,map02020	M00493	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	His_kinase
HKD3_k127_7727798_0	977880.RALTA_A2407	1.508e-73	259.0	COG0165@1|root,COG0165@2|Bacteria,1MUTU@1224|Proteobacteria,2VH47@28216|Betaproteobacteria,1K0Y8@119060|Burkholderiaceae	28216|Betaproteobacteria	E	argininosuccinate lyase	argH	-	4.3.2.1	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01086	RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ASL_C2,Lyase_1
HKD3_k127_7749427_4	296591.Bpro_1260	2.216e-147	473.0	COG0395@1|root,COG0395@2|Bacteria,1N4I0@1224|Proteobacteria,2VNEK@28216|Betaproteobacteria,4AEIK@80864|Comamonadaceae	28216|Betaproteobacteria	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
HKD3_k127_7749427_2	864051.BurJ1DRAFT_0686	1.512e-158	508.0	COG1175@1|root,COG1175@2|Bacteria,1MWB7@1224|Proteobacteria,2VHA0@28216|Betaproteobacteria,1KKBG@119065|unclassified Burkholderiales	28216|Betaproteobacteria	U	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02025,ko:K10237	ko02010,map02010	M00204,M00207	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.17	-	-	BPD_transp_1
HKD3_k127_7749427_0	595537.Varpa_5385	8.052e-211	662.0	COG1653@1|root,COG1653@2|Bacteria,1MU64@1224|Proteobacteria,2VJYY@28216|Betaproteobacteria,4ACCN@80864|Comamonadaceae	28216|Betaproteobacteria	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1,SBP_bac_8
HKD3_k127_7749427_3	1095769.CAHF01000007_gene1662	1.661e-157	507.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2VGZM@28216|Betaproteobacteria	28216|Betaproteobacteria	P	Part of the ABC transporter complex UgpABCE involved in sn-glycerol-3-phosphate import. Responsible for energy coupling to the transport system	-	-	-	ko:K10112	ko02010,map02010	M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1	-	-	ABC_tran,TOBE_2
HKD3_k127_7749427_6	1071679.BG57_31385	3.575e-124	406.0	COG1052@1|root,COG1052@2|Bacteria,1RAWT@1224|Proteobacteria,2VRZN@28216|Betaproteobacteria	28216|Betaproteobacteria	CH	D-isomer specific 2-hydroxyacid dehydrogenase	-	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
HKD3_k127_7749427_1	1122214.AQWH01000003_gene4062	6.509e-163	520.0	COG0620@1|root,COG0620@2|Bacteria,1MUI9@1224|Proteobacteria,2TTWK@28211|Alphaproteobacteria,2PKRY@255475|Aurantimonadaceae	28211|Alphaproteobacteria	E	Cobalamin-independent synthase, Catalytic domain	MA20_32395	-	2.1.1.14,4.4.1.23	ko:K00549,ko:K22363	ko00270,ko00450,ko00625,ko01100,ko01110,ko01230,map00270,map00450,map00625,map01100,map01110,map01230	M00017	R04405,R09365,R11897,R11899	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Meth_synt_2
HKD3_k127_7749427_10	887327.HMPREF0476_0342	1.82e-31	124.0	COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,2VVTG@28216|Betaproteobacteria,2KRPH@206351|Neisseriales	206351|Neisseriales	K	Cold-shock DNA-binding domain protein	-	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
HKD3_k127_7749427_5	420662.Mpe_A0126	1.194e-128	421.0	COG1118@1|root,COG1118@2|Bacteria,1QTTT@1224|Proteobacteria,2VH92@28216|Betaproteobacteria,1KKEI@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system	cysA	-	3.6.3.25	ko:K02045	ko00920,ko02010,map00920,map02010	M00185	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.6.1,3.A.1.6.3	-	-	ABC_tran,TOBE_3
HKD3_k127_7749427_7	395495.Lcho_3806	1.507e-121	411.0	COG4208@1|root,COG4208@2|Bacteria,1MV8X@1224|Proteobacteria,2VI3S@28216|Betaproteobacteria,1KJAP@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	cysW	-	-	ko:K02047	ko00920,ko02010,map00920,map02010	M00185	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.1,3.A.1.6.3	-	-	BPD_transp_1
HKD3_k127_7749427_8	1288494.EBAPG3_4720	5.118e-116	392.0	COG0555@1|root,COG0555@2|Bacteria,1QTTU@1224|Proteobacteria,2VHKY@28216|Betaproteobacteria,372C9@32003|Nitrosomonadales	28216|Betaproteobacteria	P	PFAM binding-protein-dependent transport systems inner membrane component	cysT	-	-	ko:K02046,ko:K15496	ko00920,ko02010,map00920,map02010	M00185,M00423	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.1,3.A.1.6.3,3.A.1.6.5	-	-	BPD_transp_1
HKD3_k127_7749427_9	983917.RGE_46230	2.486e-111	362.0	COG1613@1|root,COG1613@2|Bacteria,1MUAU@1224|Proteobacteria,2VIQZ@28216|Betaproteobacteria,1KJR9@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	Bacterial extracellular solute-binding protein	sbp	-	-	ko:K02048	ko00920,ko02010,map00920,map02010	M00185	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.1,3.A.1.6.3	-	-	SBP_bac_11
HKD3_k127_7807676_2	395495.Lcho_0055	7.638e-27	115.0	COG3850@1|root,COG3850@2|Bacteria,1QW6N@1224|Proteobacteria	1224|Proteobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	2.7.13.3,4.6.1.1	ko:K01768,ko:K07678	ko00230,ko02020,ko02025,ko02026,ko04113,ko04213,ko05111,map00230,map02020,map02025,map02026,map04113,map04213,map05111	M00475,M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	DUF2222,GAF_2,Guanylate_cyc,HAMP,dCache_1
HKD3_k127_7807676_1	1126627.BAWE01000002_gene856	6.27e-74	261.0	COG2984@1|root,COG2984@2|Bacteria,1R7C2@1224|Proteobacteria,2TZKG@28211|Alphaproteobacteria,3JXR0@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	-	-	-	-	-	-	-	-	-	ABC_sub_bind
HKD3_k127_7807676_0	189753.AXAS01000075_gene6004	3.687e-78	274.0	COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,2TSG1@28211|Alphaproteobacteria,3JSYZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
HKD3_k127_7831418_5	1163617.SCD_n01772	2.455e-190	598.0	COG1219@1|root,COG1219@2|Bacteria,1MVQK@1224|Proteobacteria,2VIEU@28216|Betaproteobacteria	28216|Betaproteobacteria	O	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP	clpX	-	-	ko:K03544	ko04112,map04112	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA_2,ClpB_D2-small,zf-C4_ClpX
HKD3_k127_7831418_10	1123393.KB891329_gene990	2.798e-104	345.0	COG0740@1|root,COG0740@2|Bacteria,1MV46@1224|Proteobacteria,2VHAZ@28216|Betaproteobacteria,1KRDV@119069|Hydrogenophilales	119069|Hydrogenophilales	OU	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins	clpP	-	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	CLP_protease
HKD3_k127_7831418_6	1304883.KI912532_gene2189	7.414e-141	462.0	COG0544@1|root,COG0544@2|Bacteria,1MUJP@1224|Proteobacteria,2VING@28216|Betaproteobacteria,2KU9B@206389|Rhodocyclales	206389|Rhodocyclales	D	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase	tig	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03545	-	-	-	-	ko00000	-	-	-	FKBP_C,Trigger_C,Trigger_N
HKD3_k127_7831418_12	864073.HFRIS_013549	8.402e-86	292.0	COG1562@1|root,COG1562@2|Bacteria,1N6J2@1224|Proteobacteria,2VIZC@28216|Betaproteobacteria,473HF@75682|Oxalobacteraceae	28216|Betaproteobacteria	I	Squalene/phytoene synthase	hpnC	-	2.5.1.32,2.5.1.99	ko:K02291	ko00906,ko01062,ko01100,ko01110,map00906,map01062,map01100,map01110	M00097	R02065,R04218,R07270,R10177	RC00362,RC01101,RC02869	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	SQS_PSY
HKD3_k127_7831418_11	1000565.METUNv1_00666	1.481e-103	377.0	COG1562@1|root,COG1562@2|Bacteria,1MX4W@1224|Proteobacteria,2VJ13@28216|Betaproteobacteria,2KUHC@206389|Rhodocyclales	206389|Rhodocyclales	I	Squalene synthase HpnD	-	-	2.5.1.32,2.5.1.99	ko:K02291	ko00906,ko01062,ko01100,ko01110,map00906,map01062,map01100,map01110	M00097	R02065,R04218,R07270,R10177	RC00362,RC01101,RC02869	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	SQS_PSY
HKD3_k127_7831418_14	76114.ebA6811	6.554e-75	271.0	COG1232@1|root,COG1232@2|Bacteria,1NQUH@1224|Proteobacteria,2VJV1@28216|Betaproteobacteria,2KVAB@206389|Rhodocyclales	206389|Rhodocyclales	H	squalene-associated FAD-dependent desaturase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
HKD3_k127_7831418_13	1217718.ALOU01000009_gene1023	1.207e-75	269.0	COG1028@1|root,COG1028@2|Bacteria,1MXWI@1224|Proteobacteria,2VJIU@28216|Betaproteobacteria	28216|Betaproteobacteria	IQ	Short-chain dehydrogenase reductase (SDR)	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HKD3_k127_7831418_4	1123242.JH636435_gene3078	1.511e-216	690.0	COG0318@1|root,COG0318@2|Bacteria,2J325@203682|Planctomycetes	203682|Planctomycetes	IQ	AMP-binding enzyme C-terminal domain	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
HKD3_k127_7831418_18	292415.Tbd_1756	2.592e-64	226.0	COG0691@1|root,COG0691@2|Bacteria,1RDFP@1224|Proteobacteria,2VRG9@28216|Betaproteobacteria,1KRM7@119069|Hydrogenophilales	119069|Hydrogenophilales	O	SmpB protein	-	-	-	ko:K03664	-	-	-	-	ko00000	-	-	-	SmpB
HKD3_k127_7831418_25	1485544.JQKP01000003_gene135	1.075e-44	169.0	COG2867@1|root,COG2867@2|Bacteria,1RGUH@1224|Proteobacteria,2VR4X@28216|Betaproteobacteria,44VUY@713636|Nitrosomonadales	28216|Betaproteobacteria	I	Polyketide cyclase / dehydrase and lipid transport	ratA	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc
HKD3_k127_7831418_32	1205753.A989_06913	3.096e-13	76.0	COG2914@1|root,COG2914@2|Bacteria	2|Bacteria	S	Belongs to the UPF0125 (RnfH) family	rnfH	-	-	ko:K03154,ko:K09801	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	Ub-RnfH
HKD3_k127_7831418_24	1218084.BBJK01000028_gene2701	1.494e-46	175.0	COG0791@1|root,COG0791@2|Bacteria,1RGPT@1224|Proteobacteria,2WEAT@28216|Betaproteobacteria,1K2X6@119060|Burkholderiaceae	28216|Betaproteobacteria	M	NLP P60 protein	-	-	-	-	-	-	-	-	-	-	-	-	NLPC_P60
HKD3_k127_7831418_28	323848.Nmul_A1380	1.484e-38	154.0	COG0666@1|root,COG0666@2|Bacteria,1N952@1224|Proteobacteria,2VPIV@28216|Betaproteobacteria,3733C@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Ankyrin repeat	arp3	-	-	ko:K06867	-	-	-	-	ko00000	-	-	-	Ank_2,Ank_3,Ank_4,Ank_5
HKD3_k127_7831418_8	1217718.ALOU01000097_gene4928	8.632e-108	360.0	COG0084@1|root,COG0084@2|Bacteria,1MUC0@1224|Proteobacteria,2VHCT@28216|Betaproteobacteria,1K1E9@119060|Burkholderiaceae	28216|Betaproteobacteria	L	TIGRFAM hydrolase, TatD family	ycfH	-	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
HKD3_k127_7831418_26	1163617.SCD_n01525	2.858e-43	161.0	COG3215@1|root,COG3215@2|Bacteria,1RGWZ@1224|Proteobacteria,2VT2B@28216|Betaproteobacteria	28216|Betaproteobacteria	NU	PFAM Type IV pilus assembly PilZ	pilZ	-	-	ko:K02676	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilZ
HKD3_k127_7831418_20	216591.BCAL1963	8.285e-59	222.0	COG0470@1|root,COG0470@2|Bacteria,1MY1W@1224|Proteobacteria,2VNED@28216|Betaproteobacteria,1K0JG@119060|Burkholderiaceae	28216|Betaproteobacteria	L	dna polymerase iii	holB	-	2.7.7.7	ko:K02341	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNApol3-delta_C
HKD3_k127_7831418_16	1121035.AUCH01000001_gene1830	3.144e-73	256.0	COG0125@1|root,COG0125@2|Bacteria,1MV9C@1224|Proteobacteria,2VQ24@28216|Betaproteobacteria,2KW0K@206389|Rhodocyclales	206389|Rhodocyclales	F	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis	tmk	-	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylate_kin
HKD3_k127_7831418_9	1454004.AW11_01221	1.037e-105	354.0	COG1559@1|root,COG1559@2|Bacteria,1MUQF@1224|Proteobacteria,2VHD4@28216|Betaproteobacteria,1KPZ8@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	S	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation	mltG	-	-	ko:K07082	-	-	-	-	ko00000	-	-	-	YceG
HKD3_k127_7831418_19	266264.Rmet_3384	8.909e-64	226.0	COG2165@1|root,COG2165@2|Bacteria,1RDX2@1224|Proteobacteria,2VR7N@28216|Betaproteobacteria,1KH6M@119060|Burkholderiaceae	28216|Betaproteobacteria	U	general secretion pathway protein G	gspG	-	-	ko:K02456	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl,T2SSG
HKD3_k127_7831418_34	243365.CV_3810	3.393e-07	61.0	COG2165@1|root,COG2165@2|Bacteria	2|Bacteria	NU	general secretion pathway protein	gspH	GO:0002790,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0032940,GO:0033036,GO:0042886,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0071702,GO:0071705	-	ko:K02456,ko:K02457,ko:K02458,ko:K02650	ko02020,ko03070,ko05111,map02020,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15,3.A.15.2	-	-	GspH,N_methyl
HKD3_k127_7831418_31	580332.Slit_0494	1.118e-19	100.0	COG2165@1|root,COG2165@2|Bacteria,1N737@1224|Proteobacteria	1224|Proteobacteria	NU	General secretion pathway protein I	gspI	GO:0002790,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0032940,GO:0033036,GO:0042886,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0071702,GO:0071705	-	ko:K02458	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl,T2SSI
HKD3_k127_7831418_30	323848.Nmul_A1895	1.416e-21	106.0	COG4795@1|root,COG4795@2|Bacteria,1Q8VQ@1224|Proteobacteria,2WBWY@28216|Betaproteobacteria,373Y8@32003|Nitrosomonadales	28216|Betaproteobacteria	U	Type II secretion system (T2SS), protein J	-	-	-	ko:K02459	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl,T2SSJ
HKD3_k127_7831418_21	1163408.UU9_12148	1.415e-54	207.0	COG3156@1|root,COG3156@2|Bacteria,1RAQM@1224|Proteobacteria,1S2N8@1236|Gammaproteobacteria,1X561@135614|Xanthomonadales	135614|Xanthomonadales	U	Type II secretion system protein K	xcsK	-	-	ko:K02460	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSK
HKD3_k127_7831418_36	1158292.JPOE01000002_gene3708	5.293e-06	59.0	COG3297@1|root,COG3297@2|Bacteria,1MX9I@1224|Proteobacteria,2VH8V@28216|Betaproteobacteria,1KJQQ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	U	General secretion pathway	gspL	-	-	ko:K02461	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	GspL_C,T2SSL
HKD3_k127_7831418_22	1120999.JONM01000026_gene1550	6.168e-52	195.0	COG3503@1|root,COG3503@2|Bacteria,1RA1Q@1224|Proteobacteria,2VNUA@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Protein of unknown function (DUF1624)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1624
HKD3_k127_7831418_7	1232410.KI421421_gene3491	8.009e-131	439.0	COG3408@1|root,COG3408@2|Bacteria,1PGVT@1224|Proteobacteria,42Z6Q@68525|delta/epsilon subdivisions,2WURJ@28221|Deltaproteobacteria,43TU0@69541|Desulfuromonadales	28221|Deltaproteobacteria	G	Alkaline and neutral invertase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_100
HKD3_k127_7831418_2	397945.Aave_2024	0.0	1007.0	COG0296@1|root,COG0296@2|Bacteria,1MVM7@1224|Proteobacteria,2W14D@28216|Betaproteobacteria,4AJPK@80864|Comamonadaceae	28216|Betaproteobacteria	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position	glgB	-	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48
HKD3_k127_7831418_3	472759.Nhal_2490	1.304e-292	911.0	COG0366@1|root,COG0366@2|Bacteria,1MWBZ@1224|Proteobacteria,1RYKS@1236|Gammaproteobacteria,1WX35@135613|Chromatiales	135613|Chromatiales	G	Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB	glgE	-	2.4.99.16	ko:K16147	ko00500,ko01100,map00500,map01100	-	R09994	-	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,DUF3416
HKD3_k127_7831418_0	1157708.KB907450_gene5829	0.0	1487.0	COG0366@1|root,COG3281@1|root,COG0366@2|Bacteria,COG3281@2|Bacteria,1MVKX@1224|Proteobacteria,2VHW5@28216|Betaproteobacteria,4ABG1@80864|Comamonadaceae	28216|Betaproteobacteria	G	SMART alpha amylase catalytic sub domain	treS	-	3.2.1.1,5.4.99.16	ko:K05343	ko00500,ko01100,map00500,map01100	-	R01557,R02108,R02112,R11262	RC01816	ko00000,ko00001,ko01000	-	GH13	-	APH,Alpha-amylase,Malt_amylase_C
HKD3_k127_7831418_15	987059.RBXJA2T_07993	1.956e-73	254.0	COG0668@1|root,COG0668@2|Bacteria,1N2GE@1224|Proteobacteria,2WFQP@28216|Betaproteobacteria	28216|Betaproteobacteria	M	PFAM Conserved TM helix repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	TM_helix
HKD3_k127_7831418_17	1485544.JQKP01000007_gene1968	2.276e-67	241.0	COG0837@1|root,COG0837@2|Bacteria,1MVFI@1224|Proteobacteria,2VH5F@28216|Betaproteobacteria,44VRA@713636|Nitrosomonadales	28216|Betaproteobacteria	H	Belongs to the bacterial glucokinase family	glk	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Glucokinase,HTH_6,SIS
HKD3_k127_7831418_35	269800.Tfu_3036	5.71e-07	61.0	COG0589@1|root,COG0589@2|Bacteria,2GMFE@201174|Actinobacteria,4EJD9@85012|Streptosporangiales	201174|Actinobacteria	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD3_k127_7831418_23	1122201.AUAZ01000014_gene254	1.41e-46	169.0	COG3461@1|root,COG3461@2|Bacteria,1MZZN@1224|Proteobacteria,1S688@1236|Gammaproteobacteria,4687U@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Evidence 4 Homologs of previously reported genes of	-	-	-	ko:K09700	-	-	-	-	ko00000	-	-	-	-
HKD3_k127_7831418_33	640081.Dsui_0871	7.614e-10	65.0	COG4575@1|root,COG4575@2|Bacteria,1N6X7@1224|Proteobacteria,2WFR8@28216|Betaproteobacteria,2KX05@206389|Rhodocyclales	206389|Rhodocyclales	S	Bacterial protein of unknown function (DUF883)	-	-	-	-	-	-	-	-	-	-	-	-	DUF883
HKD3_k127_7831418_27	338969.Rfer_0637	1.013e-40	161.0	COG2905@1|root,COG2905@2|Bacteria,1N7MU@1224|Proteobacteria,2VVGU@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
HKD3_k127_7831418_1	1095769.CAHF01000011_gene2475	0.0	1050.0	COG0441@1|root,COG0441@2|Bacteria,1MUP2@1224|Proteobacteria,2VHFD@28216|Betaproteobacteria,472DF@75682|Oxalobacteraceae	28216|Betaproteobacteria	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	-	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD
HKD3_k127_7831418_29	522306.CAP2UW1_1210	3.54e-38	145.0	COG0290@1|root,COG0290@2|Bacteria,1RDD2@1224|Proteobacteria,2VQ19@28216|Betaproteobacteria,1KQ06@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	J	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins	infC	-	-	ko:K02520	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	IF3_C,IF3_N
HKD3_k127_784296_7	156889.Mmc1_1535	3.435e-42	156.0	COG0451@1|root,COG0451@2|Bacteria,1MXKV@1224|Proteobacteria,2TRM0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	GM	Nad-dependent epimerase dehydratase	-	-	4.1.1.35	ko:K08678	ko00520,ko01100,map00520,map01100	M00361	R01384	RC00508	ko00000,ko00001,ko00002,ko01000	-	-	-	GDP_Man_Dehyd
HKD3_k127_784296_6	575540.Isop_2075	3.421e-42	173.0	COG1215@1|root,COG1215@2|Bacteria,2J02Q@203682|Planctomycetes	203682|Planctomycetes	M	glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HKD3_k127_784296_1	557598.LHK_02039	2.186e-188	601.0	COG1066@1|root,COG1066@2|Bacteria,1MUJQ@1224|Proteobacteria,2VH93@28216|Betaproteobacteria,2KPX7@206351|Neisseriales	206351|Neisseriales	L	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function	radA	-	-	ko:K04485	-	-	-	-	ko00000,ko03400	-	-	-	AAA_25,ATPase,ChlI
HKD3_k127_784296_3	1454004.AW11_01590	7.249e-125	413.0	COG2870@1|root,COG2870@2|Bacteria,1MV3Z@1224|Proteobacteria,2VHNS@28216|Betaproteobacteria,1KQ96@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	H	pfkB family carbohydrate kinase	rfaE	-	2.7.1.167,2.7.7.70	ko:K03272,ko:K21344	ko00540,ko01100,map00540,map01100	M00064	R05644,R05646	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CTP_transf_like,PfkB
HKD3_k127_784296_9	1163617.SCD_n00331	6.131e-14	79.0	COG1495@1|root,COG1495@2|Bacteria,1RIJE@1224|Proteobacteria,2VREE@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein	dsbB	-	-	ko:K03611	-	-	-	-	ko00000,ko03110	5.A.2.1	-	-	DsbB
HKD3_k127_784296_0	640081.Dsui_1947	1.23e-211	677.0	COG1004@1|root,COG1004@2|Bacteria,1MW5U@1224|Proteobacteria,2VGZI@28216|Betaproteobacteria,2KUMY@206389|Rhodocyclales	206389|Rhodocyclales	C	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	ugd	-	1.1.1.22	ko:K00012	ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100	M00014,M00129,M00361,M00362	R00286	RC00291	ko00000,ko00001,ko00002,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
HKD3_k127_784296_4	292415.Tbd_0960	2.063e-78	270.0	COG0284@1|root,COG0284@2|Bacteria,1MW2C@1224|Proteobacteria,2VJRD@28216|Betaproteobacteria	28216|Betaproteobacteria	F	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)	pyrF	-	4.1.1.23	ko:K01591	ko00240,ko01100,map00240,map01100	M00051	R00965	RC00409	ko00000,ko00001,ko00002,ko01000	-	-	-	OMPdecase
HKD3_k127_784296_2	640081.Dsui_1946	1.514e-137	451.0	COG2956@1|root,COG2956@2|Bacteria,1MVDP@1224|Proteobacteria,2VH49@28216|Betaproteobacteria,2KU7Z@206389|Rhodocyclales	206389|Rhodocyclales	G	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane	lapB	-	-	ko:K19804	-	-	-	-	ko00000	-	-	-	TPR_16
HKD3_k127_784296_10	983917.RGE_13850	4.286e-07	59.0	COG5416@1|root,COG5416@2|Bacteria,1N4UI@1224|Proteobacteria,2VU63@28216|Betaproteobacteria,1KMI6@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Pfam:DUF1049	-	-	-	ko:K08992	-	-	-	-	ko00000	-	-	-	LapA_dom
HKD3_k127_784296_5	1288494.EBAPG3_23290	8.045e-45	164.0	COG0776@1|root,COG0776@2|Bacteria,1MZ7M@1224|Proteobacteria,2VSPN@28216|Betaproteobacteria,373DE@32003|Nitrosomonadales	28216|Betaproteobacteria	K	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control	himD	-	-	ko:K05788	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
HKD3_k127_784296_8	261292.Nit79A3_0441	1.788e-37	143.0	COG0539@1|root,COG1185@1|root,COG0539@2|Bacteria,COG1185@2|Bacteria,1MVAV@1224|Proteobacteria,2VI12@28216|Betaproteobacteria,372RZ@32003|Nitrosomonadales	28216|Betaproteobacteria	J	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence	rpsA	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
HKD3_k127_7862085_1	1123073.KB899241_gene2828	4.231e-54	198.0	2EIBB@1|root,32TVT@2|Bacteria,1MZJN@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_7862085_0	1349767.GJA_2623	1.472e-162	520.0	COG2766@1|root,COG2766@2|Bacteria,1MVW7@1224|Proteobacteria,2VI2M@28216|Betaproteobacteria,476GU@75682|Oxalobacteraceae	28216|Betaproteobacteria	T	PrkA AAA domain	-	-	-	ko:K07180	-	-	-	-	ko00000	-	-	-	AAA_PrkA,PrkA
HKD3_k127_7926150_2	1458275.AZ34_09505	1.272e-109	364.0	COG2084@1|root,COG2084@2|Bacteria,1MV48@1224|Proteobacteria,2VKTQ@28216|Betaproteobacteria,4ABGJ@80864|Comamonadaceae	28216|Betaproteobacteria	I	PFAM 6-phosphogluconate dehydrogenase NAD-binding	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_11,NAD_binding_2
HKD3_k127_7926150_3	640081.Dsui_2899	4.079e-56	210.0	COG0697@1|root,COG0697@2|Bacteria,1MXVF@1224|Proteobacteria,2VKMQ@28216|Betaproteobacteria,2KVQX@206389|Rhodocyclales	206389|Rhodocyclales	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HKD3_k127_7926150_1	257310.BB4460	4.008e-120	392.0	COG0351@1|root,COG0351@2|Bacteria,1MU9J@1224|Proteobacteria,2VHWQ@28216|Betaproteobacteria,3T1X4@506|Alcaligenaceae	28216|Betaproteobacteria	H	Phosphomethylpyrimidine kinase	thiD	-	2.7.1.49,2.7.4.7	ko:K00941	ko00730,ko01100,map00730,map01100	M00127	R03471,R04509	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Phos_pyr_kin
HKD3_k127_7926150_0	1095769.CAHF01000001_gene3520	7.185e-151	485.0	COG0422@1|root,COG0422@2|Bacteria,1MUVV@1224|Proteobacteria,2VHS3@28216|Betaproteobacteria,472N5@75682|Oxalobacteraceae	28216|Betaproteobacteria	H	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction	thiC	-	4.1.99.17	ko:K03147	ko00730,ko01100,map00730,map01100	M00127	R03472	RC03251,RC03252	ko00000,ko00001,ko00002,ko01000	-	-	-	ThiC-associated,ThiC_Rad_SAM
HKD3_k127_7979694_0	999541.bgla_2g29110	2.011e-166	525.0	COG0473@1|root,COG0473@2|Bacteria,1MUH4@1224|Proteobacteria,2VHN0@28216|Betaproteobacteria,1K2HI@119060|Burkholderiaceae	28216|Betaproteobacteria	CE	Tartrate dehydrogenase	-	-	1.1.1.83,1.1.1.93,4.1.1.73	ko:K07246	ko00630,ko00650,map00630,map00650	-	R00215,R01751,R02545,R06180	RC00084,RC00105,RC00594	ko00000,ko00001,ko01000	-	-	-	Iso_dh
HKD3_k127_7979694_1	296591.Bpro_0722	7.14e-100	329.0	COG0583@1|root,COG0583@2|Bacteria,1MVJ7@1224|Proteobacteria,2VHIJ@28216|Betaproteobacteria,4ABDK@80864|Comamonadaceae	28216|Betaproteobacteria	K	Transcriptional regulator, LysR	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HKD3_k127_8126790_2	748247.AZKH_0645	4.781e-146	471.0	COG0008@1|root,COG0008@2|Bacteria,1MUC8@1224|Proteobacteria,2VHZX@28216|Betaproteobacteria,2KVV7@206389|Rhodocyclales	206389|Rhodocyclales	J	glutaminyl-tRNA	glnS	-	6.1.1.18	ko:K01886	ko00970,ko01100,map00970,map01100	M00359,M00360	R03652	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1c,tRNA-synt_1c_C
HKD3_k127_8126790_3	1392838.AWNM01000046_gene2017	9.831e-122	399.0	COG0501@1|root,COG0501@2|Bacteria,1MUV4@1224|Proteobacteria,2VIVB@28216|Betaproteobacteria,3T1UG@506|Alcaligenaceae	28216|Betaproteobacteria	O	Belongs to the peptidase M48B family	htpX	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
HKD3_k127_8126790_13	1430440.MGMSRv2_2525	9.202e-37	148.0	COG0625@1|root,COG0625@2|Bacteria,1MUN3@1224|Proteobacteria,2TTVR@28211|Alphaproteobacteria,2JPS1@204441|Rhodospirillales	204441|Rhodospirillales	O	Belongs to the GST superfamily	-	-	-	ko:K11209	-	-	-	-	ko00000,ko01000	-	-	-	GST_C,GST_N,GST_N_3
HKD3_k127_8126790_11	864051.BurJ1DRAFT_4936	1.814e-43	162.0	COG5531@1|root,COG5531@2|Bacteria,1N3MD@1224|Proteobacteria,2VSPC@28216|Betaproteobacteria,1KMDW@119065|unclassified Burkholderiales	28216|Betaproteobacteria	B	SWI complex, BAF60b domains	-	-	-	-	-	-	-	-	-	-	-	-	SWIB
HKD3_k127_8126790_7	338969.Rfer_0960	1.198e-86	301.0	COG0477@1|root,COG2814@2|Bacteria,1R3WC@1224|Proteobacteria,2VKT9@28216|Betaproteobacteria	28216|Betaproteobacteria	EGP	major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD3_k127_8126790_9	1336208.JADY01000001_gene1109	1.359e-71	249.0	COG0225@1|root,COG0225@2|Bacteria,1MVUS@1224|Proteobacteria,2TSAM@28211|Alphaproteobacteria,2JPX2@204441|Rhodospirillales	204441|Rhodospirillales	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	msrA	-	1.8.4.11	ko:K07304	-	-	-	-	ko00000,ko01000	-	-	-	PMSR
HKD3_k127_8126790_10	580332.Slit_0742	2.015e-49	197.0	COG1295@1|root,COG1295@2|Bacteria,1QICW@1224|Proteobacteria,2VJNM@28216|Betaproteobacteria,44VKC@713636|Nitrosomonadales	28216|Betaproteobacteria	S	Virulence factor BrkB	rbn	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Virul_fac_BrkB
HKD3_k127_8126790_8	279714.FuraDRAFT_2876	5.084e-80	273.0	COG0811@1|root,COG0811@2|Bacteria,1QNJ1@1224|Proteobacteria,2VITY@28216|Betaproteobacteria,2KQBN@206351|Neisseriales	206351|Neisseriales	U	MotA/TolQ/ExbB proton channel family	-	-	-	ko:K03561	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	MotA_ExbB
HKD3_k127_8126790_12	1163617.SCD_n01894	2.563e-40	156.0	COG0848@1|root,COG0848@2|Bacteria,1N0ZA@1224|Proteobacteria,2VUF4@28216|Betaproteobacteria	28216|Betaproteobacteria	U	Biopolymer transport protein	exbD2	-	-	ko:K03559	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	ExbD
HKD3_k127_8126790_6	580332.Slit_1364	6.207e-90	308.0	COG1663@1|root,COG1663@2|Bacteria,1MU8G@1224|Proteobacteria,2VHPG@28216|Betaproteobacteria,44UYT@713636|Nitrosomonadales	28216|Betaproteobacteria	M	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)	lpxK	-	2.7.1.130	ko:K00912	ko00540,ko01100,map00540,map01100	M00060	R04657	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	LpxK
HKD3_k127_8126790_14	1122236.KB905141_gene1475	1.594e-25	106.0	COG2835@1|root,COG2835@2|Bacteria,1N6Y2@1224|Proteobacteria,2VW58@28216|Betaproteobacteria,2KNA4@206350|Nitrosomonadales	206350|Nitrosomonadales	S	Belongs to the UPF0434 family	-	-	-	ko:K09791	-	-	-	-	ko00000	-	-	-	Trm112p
HKD3_k127_8126790_5	381666.H16_A0604	2.808e-96	327.0	COG1212@1|root,COG1212@2|Bacteria,1MUUU@1224|Proteobacteria,2VINM@28216|Betaproteobacteria,1K2A1@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria	kdsB	-	2.7.7.38	ko:K00979	ko00540,ko01100,map00540,map01100	M00063	R03351,R11396	RC00152,RC00910	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CTP_transf_3
HKD3_k127_8126790_4	375286.mma_2576	2.629e-105	355.0	COG0563@1|root,COG0563@2|Bacteria,1MXCZ@1224|Proteobacteria,2VH1C@28216|Betaproteobacteria,472VC@75682|Oxalobacteraceae	28216|Betaproteobacteria	F	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism	adk	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ADK,ADK_lid
HKD3_k127_8126790_1	243233.MCA1251	1.772e-203	640.0	COG0205@1|root,COG0205@2|Bacteria,1MVN3@1224|Proteobacteria,1SX3B@1236|Gammaproteobacteria,1XDZ9@135618|Methylococcales	135618|Methylococcales	F	Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions	pfp	-	2.7.1.11,2.7.1.90	ko:K00895,ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
HKD3_k127_8126790_0	522306.CAP2UW1_0384	0.0	1100.0	COG2885@1|root,COG3808@1|root,COG2885@2|Bacteria,COG3808@2|Bacteria,1MUQ3@1224|Proteobacteria,2VI3K@28216|Betaproteobacteria,1KQ7I@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	C	Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase,OmpA
HKD3_k127_8466201_2	1144275.COCOR_07348	3.091e-29	124.0	COG1595@1|root,COG1595@2|Bacteria,1MX7T@1224|Proteobacteria,42U04@68525|delta/epsilon subdivisions,2WQA9@28221|Deltaproteobacteria,2YV9U@29|Myxococcales	28221|Deltaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD3_k127_8466201_3	1110502.TMO_1528	6.403e-13	72.0	COG1366@1|root,COG1366@2|Bacteria,1N7D9@1224|Proteobacteria,2UH20@28211|Alphaproteobacteria,2JTY1@204441|Rhodospirillales	204441|Rhodospirillales	T	Belongs to the anti-sigma-factor antagonist family	-	-	-	ko:K04749	-	-	-	-	ko00000,ko03021	-	-	-	STAS,STAS_2
HKD3_k127_8466201_4	243233.MCA1666	6.849e-11	76.0	COG2172@1|root,COG2172@2|Bacteria,1PVRH@1224|Proteobacteria,1RU0B@1236|Gammaproteobacteria,1XGSJ@135618|Methylococcales	135618|Methylococcales	T	Histidine kinase-like ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c_2
HKD3_k127_8466201_1	1254432.SCE1572_38865	1.71e-108	376.0	COG2203@1|root,COG2208@1|root,COG2203@2|Bacteria,COG2208@2|Bacteria,1R7WZ@1224|Proteobacteria,42Q3R@68525|delta/epsilon subdivisions,2WM5A@28221|Deltaproteobacteria	28221|Deltaproteobacteria	KT	SMART protein phosphatase 2C domain protein	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	GAF_2,SSF,SpoIIE
HKD3_k127_8466201_0	420662.Mpe_A2185	1.582e-218	694.0	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2VIAP@28216|Betaproteobacteria,1KJ8T@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	ABC transporter transmembrane region	-	-	-	ko:K06147,ko:K18893	ko02010,map02010	-	-	-	ko00000,ko00001,ko02000	3.A.1,3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
HKD3_k127_847681_37	160488.PP_3791	1.035e-25	106.0	COG0582@1|root,COG0582@2|Bacteria,1P1R9@1224|Proteobacteria,1RRV0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Integrase	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
HKD3_k127_847681_35	93220.LV28_14485	3.222e-32	134.0	COG2963@1|root,COG2963@2|Bacteria,1MZ3D@1224|Proteobacteria,2VUTU@28216|Betaproteobacteria,1K9RG@119060|Burkholderiaceae	28216|Betaproteobacteria	L	Evidence 2b Function of strongly homologous gene	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_Tnp_1
HKD3_k127_847681_8	1288494.EBAPG3_26060	1.284e-144	469.0	COG0582@1|root,COG0582@2|Bacteria,1MU23@1224|Proteobacteria,2VHG5@28216|Betaproteobacteria,371Q8@32003|Nitrosomonadales	28216|Betaproteobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Arm-DNA-bind_3,Phage_int_SAM_3,Phage_integrase
HKD3_k127_847681_23	864051.BurJ1DRAFT_4198	1.281e-67	236.0	COG2227@1|root,COG2227@2|Bacteria,1QVH1@1224|Proteobacteria,2VRX7@28216|Betaproteobacteria,1KKJH@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	Thiopurine S-methyltransferase (TPMT)	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
HKD3_k127_847681_7	1266925.JHVX01000007_gene2330	2.716e-155	502.0	COG1914@1|root,COG1914@2|Bacteria,1MW6X@1224|Proteobacteria,2VK6I@28216|Betaproteobacteria	28216|Betaproteobacteria	P	Natural resistance-associated macrophage protein	-	-	-	-	-	-	-	-	-	-	-	-	Nramp
HKD3_k127_847681_2	338969.Rfer_2145	8.163e-277	880.0	COG0204@1|root,COG0236@1|root,COG0318@1|root,COG0204@2|Bacteria,COG0236@2|Bacteria,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2WGHZ@28216|Betaproteobacteria,4AB3C@80864|Comamonadaceae	28216|Betaproteobacteria	IQ	PFAM AMP-dependent synthetase and ligase	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,Acyltransferase,PP-binding
HKD3_k127_847681_18	977880.RALTA_A1714	1.373e-82	284.0	COG4589@1|root,COG4589@2|Bacteria,1MX58@1224|Proteobacteria,2VH1P@28216|Betaproteobacteria,1K6P8@119060|Burkholderiaceae	28216|Betaproteobacteria	M	phosphatidate Cytidylyltransferase	-	-	2.7.7.41	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_1
HKD3_k127_847681_26	1111728.ATYS01000015_gene4732	1.012e-49	184.0	COG4319@1|root,COG4319@2|Bacteria,1RBU6@1224|Proteobacteria,1S33C@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	ketosteroid isomerase	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_3
HKD3_k127_847681_22	757424.Hsero_0080	3.99e-71	245.0	COG0558@1|root,COG0558@2|Bacteria,1RE0I@1224|Proteobacteria,2VR68@28216|Betaproteobacteria	28216|Betaproteobacteria	I	CDP-alcohol phosphatidyltransferase	-	-	2.7.8.5	ko:K00995	ko00564,ko01100,map00564,map01100	-	R01801	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
HKD3_k127_847681_4	62928.azo0664	5.943e-239	751.0	COG2267@1|root,COG2267@2|Bacteria,1MWF5@1224|Proteobacteria,2VNMX@28216|Betaproteobacteria,2KUGJ@206389|Rhodocyclales	206389|Rhodocyclales	I	Putative methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4,Methyltransf_20
HKD3_k127_847681_9	1437882.AZRU01000061_gene4058	1.27e-143	492.0	COG0671@1|root,COG2453@1|root,COG0671@2|Bacteria,COG2453@2|Bacteria,1QSUD@1224|Proteobacteria,1RQAC@1236|Gammaproteobacteria,1YDPJ@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	IT	Dual specificity phosphatase, catalytic domain	ynbD	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	3.1.3.16	ko:K01090	-	-	-	-	ko00000,ko01000	-	-	-	DAGK_cat,DSPc,PAP2_3
HKD3_k127_847681_25	868131.MSWAN_1839	1.897e-51	207.0	COG1926@1|root,arCOG00041@2157|Archaea,2XWHP@28890|Euryarchaeota	28890|Euryarchaeota	F	phosphoribosyltransferases	prt	-	-	-	-	-	-	-	-	-	-	-	Pribosyltran
HKD3_k127_847681_32	697282.Mettu_0374	1.093e-38	150.0	COG0517@1|root,COG0517@2|Bacteria,1QJRF@1224|Proteobacteria,1THSQ@1236|Gammaproteobacteria,1XFJQ@135618|Methylococcales	135618|Methylococcales	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
HKD3_k127_847681_33	1123393.KB891326_gene63	6.99e-38	145.0	COG1734@1|root,COG1734@2|Bacteria,1NH80@1224|Proteobacteria,2VY9Z@28216|Betaproteobacteria,1KT52@119069|Hydrogenophilales	119069|Hydrogenophilales	T	Prokaryotic dksA/traR C4-type zinc finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-dskA_traR
HKD3_k127_847681_15	342113.DM82_4886	4.953e-95	350.0	COG1796@1|root,COG1796@2|Bacteria,1QF8Z@1224|Proteobacteria,2WASJ@28216|Betaproteobacteria,1K40Q@119060|Burkholderiaceae	28216|Betaproteobacteria	L	Helix-hairpin-helix domain	-	-	-	ko:K04477	-	-	-	-	ko00000	-	-	-	HHH_5,HHH_8
HKD3_k127_847681_3	478741.JAFS01000002_gene790	1.726e-257	818.0	COG1067@1|root,COG1067@2|Bacteria,46YV9@74201|Verrucomicrobia,37G14@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	O	AAA domain	lonB	-	-	-	-	-	-	-	-	-	-	-	AAA_32,Lon_C
HKD3_k127_847681_39	926550.CLDAP_01920	2.105e-12	80.0	COG0589@1|root,COG0589@2|Bacteria	2|Bacteria	T	AMP binding	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD3_k127_847681_36	697282.Mettu_2218	7.332e-27	113.0	COG1531@1|root,COG1531@2|Bacteria,1N7PM@1224|Proteobacteria,1SRSR@1236|Gammaproteobacteria	1236|Gammaproteobacteria	AJ	Protein of unknown function (DUF504)	-	-	-	-	-	-	-	-	-	-	-	-	DUF504
HKD3_k127_847681_0	667632.KB890167_gene1513	0.0	1069.0	COG0280@1|root,COG0281@1|root,COG0280@2|Bacteria,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,2VIYB@28216|Betaproteobacteria,1K2P6@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Malic enzyme	maeB	-	1.1.1.40	ko:K00029	ko00620,ko00710,ko01100,ko01120,ko01200,map00620,map00710,map01100,map01120,map01200	M00169,M00172	R00216	RC00105	ko00000,ko00001,ko00002,ko01000	-	-	-	Malate_DH,Malic_M,PTA_PTB,malic
HKD3_k127_847681_28	1121035.AUCH01000025_gene3329	2.274e-47	178.0	COG4133@1|root,COG4133@2|Bacteria,1MZPC@1224|Proteobacteria,2VMGA@28216|Betaproteobacteria,2KW6J@206389|Rhodocyclales	206389|Rhodocyclales	O	once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system	ccmA	-	3.6.3.41	ko:K02193	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.107	-	-	ABC_tran
HKD3_k127_847681_21	1288494.EBAPG3_12810	1.024e-72	253.0	COG2386@1|root,COG2386@2|Bacteria,1NJB0@1224|Proteobacteria,2VNPU@28216|Betaproteobacteria,371Q1@32003|Nitrosomonadales	28216|Betaproteobacteria	U	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes	ccmB	-	-	ko:K02194	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.107	-	-	CcmB
HKD3_k127_847681_14	323848.Nmul_A1212	1.191e-108	363.0	COG0755@1|root,COG0755@2|Bacteria,1MU61@1224|Proteobacteria,2VHF8@28216|Betaproteobacteria,3729C@32003|Nitrosomonadales	28216|Betaproteobacteria	U	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes	ccmC	-	-	ko:K02195	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.107	-	-	Cytochrom_C_asm
HKD3_k127_847681_24	1288494.EBAPG3_12780	9.275e-58	204.0	COG2332@1|root,COG2332@2|Bacteria,1RHN5@1224|Proteobacteria,2VRKZ@28216|Betaproteobacteria,3731F@32003|Nitrosomonadales	28216|Betaproteobacteria	O	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH	ccmE	-	-	ko:K02197	-	-	-	-	ko00000	-	-	-	CcmE
HKD3_k127_847681_1	1131553.JIBI01000009_gene1231	2.786e-310	962.0	COG1138@1|root,COG1138@2|Bacteria,1MUQS@1224|Proteobacteria,2VHUE@28216|Betaproteobacteria,3725U@32003|Nitrosomonadales	28216|Betaproteobacteria	O	Cytochrome c-type biogenesis protein CcmF	ccmF	-	-	ko:K02198	-	-	-	-	ko00000,ko02000	9.B.14.1	-	-	CcmF_C,Cytochrom_C_asm
HKD3_k127_847681_20	153948.NAL212_1563	2.808e-74	255.0	COG0526@1|root,COG0526@2|Bacteria,1RI3N@1224|Proteobacteria,2VR8D@28216|Betaproteobacteria,372UU@32003|Nitrosomonadales	28216|Betaproteobacteria	CO	oxidoreductase DsbE	dsbE	-	-	ko:K02199	-	-	-	-	ko00000,ko03110	-	-	-	AhpC-TSA,Redoxin
HKD3_k127_847681_31	159087.Daro_3998	4.385e-41	158.0	COG3088@1|root,COG3088@2|Bacteria,1MZZ5@1224|Proteobacteria,2VU7C@28216|Betaproteobacteria,2KX2W@206389|Rhodocyclales	206389|Rhodocyclales	P	subunit of a heme lyase	-	-	-	ko:K02200	-	-	-	-	ko00000	-	-	-	CcmH
HKD3_k127_847681_17	395495.Lcho_1552	5.52e-85	300.0	COG4235@1|root,COG4235@2|Bacteria,1MY4J@1224|Proteobacteria,2VQ05@28216|Betaproteobacteria,1KKAY@119065|unclassified Burkholderiales	28216|Betaproteobacteria	O	Cytochrome c-type biogenesis protein	cycH	-	-	ko:K02200	-	-	-	-	ko00000	-	-	-	TPR_16,TPR_2
HKD3_k127_847681_5	1203554.HMPREF1476_01545	1.957e-179	579.0	COG3303@1|root,COG3303@2|Bacteria,1MVJT@1224|Proteobacteria,2W17H@28216|Betaproteobacteria,4PQ4C@995019|Sutterellaceae	28216|Betaproteobacteria	C	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C552
HKD3_k127_847681_29	522306.CAP2UW1_0720	4.731e-43	170.0	COG4235@1|root,COG4235@2|Bacteria,1MY4J@1224|Proteobacteria,2VQ05@28216|Betaproteobacteria,1KQB8@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	O	Cytochrome c-type biogenesis protein	-	-	-	ko:K02200	-	-	-	-	ko00000	-	-	-	TPR_16
HKD3_k127_847681_13	880073.Calab_3717	3.086e-110	374.0	COG1232@1|root,COG1232@2|Bacteria,2NQ1W@2323|unclassified Bacteria	2|Bacteria	H	Flavin containing amine oxidoreductase	hemG	-	1.14.19.9,1.3.3.15,1.3.3.4	ko:K00231,ko:K14266	ko00404,ko00860,ko01100,ko01110,ko01130,map00404,map00860,map01100,map01110,map01130	M00121,M00789,M00790	R03222,R04178,R09570	RC00885,RC00949	ko00000,ko00001,ko00002,ko01000	-	-	iSB619.SA_RS09325	Amino_oxidase
HKD3_k127_847681_19	748247.AZKH_p0450	1.486e-74	274.0	COG0705@1|root,COG0705@2|Bacteria,1RJYI@1224|Proteobacteria,2W1AJ@28216|Betaproteobacteria,2KXTX@206389|Rhodocyclales	206389|Rhodocyclales	S	Rhomboid family	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
HKD3_k127_847681_38	261292.Nit79A3_0699	5.255e-17	93.0	2BHIC@1|root,32BKS@2|Bacteria,1PZ7H@1224|Proteobacteria,2VYB8@28216|Betaproteobacteria,373HG@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Putative prokaryotic signal transducing protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF2007
HKD3_k127_847681_16	1122604.JONR01000025_gene4542	1.301e-90	324.0	COG3741@1|root,COG3741@2|Bacteria,1MY4D@1224|Proteobacteria,1RUSZ@1236|Gammaproteobacteria,1X5E2@135614|Xanthomonadales	135614|Xanthomonadales	E	N-formylglutamate amidohydrolase	hutG	-	3.5.1.68,3.5.3.8	ko:K01458,ko:K01479	ko00340,ko00630,ko01100,map00340,map00630,map01100	M00045	R00525,R02285	RC00165,RC00221,RC00323,RC00681	ko00000,ko00001,ko00002,ko01000	-	-	-	FGase
HKD3_k127_847681_10	392499.Swit_4633	5.124e-142	477.0	COG1228@1|root,COG1228@2|Bacteria,1MUYR@1224|Proteobacteria,2TSA1@28211|Alphaproteobacteria,2K2MP@204457|Sphingomonadales	204457|Sphingomonadales	Q	Catalyzing the hydrolysis of 4-imidazolone-5-propionate to N-formimidoyl-L-glutamate, the third step in the histidine degradation pathway	hutI	-	3.5.2.7	ko:K01468	ko00340,ko01100,map00340,map01100	M00045	R02288	RC00683	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1,Amidohydro_3
HKD3_k127_847681_11	502025.Hoch_1853	2.607e-138	466.0	COG0402@1|root,COG0402@2|Bacteria,1MUFE@1224|Proteobacteria,438T7@68525|delta/epsilon subdivisions,2X3ZR@28221|Deltaproteobacteria,2YXQF@29|Myxococcales	28221|Deltaproteobacteria	F	Amidohydrolase family	-	-	3.5.3.13	ko:K05603	ko00340,map00340	-	R02286	RC00682	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
HKD3_k127_847681_34	279714.FuraDRAFT_0160	2.622e-37	148.0	COG3758@1|root,COG3758@2|Bacteria,1RH9G@1224|Proteobacteria,2VVAA@28216|Betaproteobacteria,2KTFQ@206351|Neisseriales	206351|Neisseriales	S	HutD	-	-	-	ko:K09975	-	-	-	-	ko00000	-	-	-	HutD
HKD3_k127_847681_6	1411123.JQNH01000001_gene2359	8.976e-157	499.0	COG0715@1|root,COG0715@2|Bacteria,1MVJA@1224|Proteobacteria,2TTB8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components	MA20_34190	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
HKD3_k127_847681_27	118163.Ple7327_3130	9.486e-49	185.0	COG2267@1|root,COG2267@2|Bacteria,1G2EN@1117|Cyanobacteria,3VIY7@52604|Pleurocapsales	1117|Cyanobacteria	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4
HKD3_k127_847681_12	264198.Reut_A2719	3.522e-126	409.0	COG0600@1|root,COG0600@2|Bacteria,1MWDJ@1224|Proteobacteria,2VMK8@28216|Betaproteobacteria	28216|Betaproteobacteria	P	Pfam Binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
HKD3_k127_847681_30	629773.AORY01000004_gene449	1.86e-41	173.0	COG0457@1|root,COG3577@1|root,COG0457@2|Bacteria,COG3577@2|Bacteria,1QW7M@1224|Proteobacteria,2U1I6@28211|Alphaproteobacteria,2K1K4@204457|Sphingomonadales	204457|Sphingomonadales	S	Aspartyl protease	-	-	-	-	-	-	-	-	-	-	-	-	Asp_protease_2,TPR_16
HKD3_k127_847681_40	1287276.X752_17920	2.472e-08	66.0	COG1116@1|root,COG1116@2|Bacteria,1MUDV@1224|Proteobacteria,2TSH9@28211|Alphaproteobacteria,43K6Z@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	P	ABC-type nitrate sulfonate bicarbonate transport system ATPase component	MA20_34180	-	-	ko:K02049,ko:K15555	ko00920,ko02010,map00920,map02010	M00188,M00436	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.16,3.A.1.17,3.A.1.17.2	-	-	ABC_tran
HKD3_k127_8502985_9	1163617.SCD_n01508	1.668e-159	516.0	COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,2VH16@28216|Betaproteobacteria	1224|Proteobacteria	L	Belongs to the DEAD box helicase family	rhlE2	GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008026,GO:0008104,GO:0008150,GO:0008186,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032991,GO:0033036,GO:0035770,GO:0036464,GO:0042623,GO:0043186,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044444,GO:0044464,GO:0045495,GO:0051179,GO:0060293,GO:0070035,GO:0140098,GO:1990904	3.6.4.13	ko:K11927	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DEAD,Helicase_C
HKD3_k127_8502985_0	1288494.EBAPG3_14560	6.762e-296	921.0	COG1217@1|root,COG1217@2|Bacteria,1MV5Q@1224|Proteobacteria,2VH2W@28216|Betaproteobacteria,372H8@32003|Nitrosomonadales	28216|Betaproteobacteria	T	protein synthesis factor, GTP-binding	typA	-	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2
HKD3_k127_8502985_19	640081.Dsui_0423	8.792e-89	316.0	COG0628@1|root,COG0628@2|Bacteria,1MVX7@1224|Proteobacteria,2VIIX@28216|Betaproteobacteria,2KW9W@206389|Rhodocyclales	206389|Rhodocyclales	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
HKD3_k127_8502985_16	105559.Nwat_1010	3.175e-102	359.0	COG1404@1|root,COG1404@2|Bacteria,1MU3S@1224|Proteobacteria,1RNB8@1236|Gammaproteobacteria,1X03F@135613|Chromatiales	135613|Chromatiales	M	Subtilase family	-	-	-	ko:K14645	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002,ko03110	-	-	-	Peptidase_S8
HKD3_k127_8502985_13	335283.Neut_0407	1.476e-114	376.0	COG0483@1|root,COG0483@2|Bacteria,1MUQT@1224|Proteobacteria,2VIXG@28216|Betaproteobacteria,372NY@32003|Nitrosomonadales	28216|Betaproteobacteria	G	Inositol monophosphatase	suhB	-	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
HKD3_k127_8502985_21	1236959.BAMT01000001_gene1096	8.177e-64	235.0	COG0565@1|root,COG0565@2|Bacteria,1N47Y@1224|Proteobacteria,2VI2D@28216|Betaproteobacteria,2KM4J@206350|Nitrosomonadales	206350|Nitrosomonadales	J	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA	trmJ	-	-	ko:K02533	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	SpoU_methylase
HKD3_k127_8502985_11	1265502.KB905934_gene3259	2.148e-137	445.0	COG1638@1|root,COG1638@2|Bacteria,1MVHI@1224|Proteobacteria,2VHPP@28216|Betaproteobacteria,4ABME@80864|Comamonadaceae	28216|Betaproteobacteria	G	Bacterial extracellular solute-binding protein, family 7	-	-	-	-	-	-	-	-	-	-	-	-	DctP
HKD3_k127_8502985_18	1123393.KB891327_gene397	1.366e-97	347.0	COG1045@1|root,COG1045@2|Bacteria,1MVFX@1224|Proteobacteria,2VH8C@28216|Betaproteobacteria,1KSH1@119069|Hydrogenophilales	119069|Hydrogenophilales	E	Bacterial transferase hexapeptide (six repeats)	-	-	2.3.1.30	ko:K00640	ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111	M00021	R00586	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,SATase_N
HKD3_k127_8502985_22	522306.CAP2UW1_2019	2.142e-63	221.0	COG1959@1|root,COG1959@2|Bacteria,1RDA4@1224|Proteobacteria,2VRGK@28216|Betaproteobacteria,1KQMC@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	K	Rrf2 family transcriptional regulator, iron-sulfur cluster assembly	iscR	-	-	ko:K13643	-	-	-	-	ko00000,ko03000	-	-	-	Rrf2
HKD3_k127_8502985_3	342113.DM82_1893	8.499e-223	694.0	COG1104@1|root,COG1104@2|Bacteria,1MU1C@1224|Proteobacteria,2VH91@28216|Betaproteobacteria,1K14U@119060|Burkholderiaceae	28216|Betaproteobacteria	E	Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins	iscS	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
HKD3_k127_8502985_20	1123367.C666_02350	1.106e-67	233.0	COG0822@1|root,COG0822@2|Bacteria,1RD5K@1224|Proteobacteria,2VQ2I@28216|Betaproteobacteria,2KWB3@206389|Rhodocyclales	206389|Rhodocyclales	C	A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters	iscU	-	-	ko:K04488	-	-	-	-	ko00000	-	-	-	NifU_N
HKD3_k127_8502985_25	62928.azo2014	6.247e-55	193.0	COG0316@1|root,COG0316@2|Bacteria,1RH6T@1224|Proteobacteria,2VSKY@28216|Betaproteobacteria,2KWP9@206389|Rhodocyclales	206389|Rhodocyclales	S	Belongs to the HesB IscA family	-	-	-	ko:K13628	-	-	-	-	ko00000,ko03016	-	-	-	Fe-S_biosyn
HKD3_k127_8502985_29	667632.KB890169_gene5006	3.328e-32	134.0	COG1076@1|root,COG1076@2|Bacteria,1RHZX@1224|Proteobacteria,2VSD5@28216|Betaproteobacteria,1K1FR@119060|Burkholderiaceae	28216|Betaproteobacteria	O	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA	hscB	-	-	ko:K04082	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,HSCB_C
HKD3_k127_8502985_2	1000565.METUNv1_00566	5.213e-272	849.0	COG0443@1|root,COG0443@2|Bacteria,1MVQI@1224|Proteobacteria,2VHGV@28216|Betaproteobacteria,2KUV2@206389|Rhodocyclales	206389|Rhodocyclales	O	Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB	hscA	-	-	ko:K04044	-	-	-	-	ko00000,ko03110	1.A.33	-	-	HSP70
HKD3_k127_8502985_26	748247.AZKH_2810	5.007e-46	178.0	COG0633@1|root,COG0633@2|Bacteria,1RHDC@1224|Proteobacteria,2VSQE@28216|Betaproteobacteria,2KWP0@206389|Rhodocyclales	206389|Rhodocyclales	C	Ferredoxin, 2Fe-2S type, ISC system	-	-	-	ko:K04755	-	-	-	-	ko00000	-	-	-	Fer2
HKD3_k127_8502985_30	1123368.AUIS01000004_gene258	3.569e-28	115.0	COG2975@1|root,COG2975@2|Bacteria,1N7C1@1224|Proteobacteria,1SC9F@1236|Gammaproteobacteria,2NDAS@225057|Acidithiobacillales	225057|Acidithiobacillales	S	Iron-sulphur cluster assembly	-	-	-	-	-	-	-	-	-	-	-	-	Fe-S_assembly
HKD3_k127_8502985_5	305700.B447_00870	5.152e-192	606.0	COG0027@1|root,COG0027@2|Bacteria,1N3KA@1224|Proteobacteria,2VH4M@28216|Betaproteobacteria,2KV39@206389|Rhodocyclales	206389|Rhodocyclales	F	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate	purT	-	2.1.2.2	ko:K08289	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	M00048	R04325,R04326	RC00026,RC00197,RC01128	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp,Epimerase
HKD3_k127_8502985_1	580332.Slit_1427	1.939e-284	893.0	COG0557@1|root,COG0557@2|Bacteria,1MUS6@1224|Proteobacteria,2VHBJ@28216|Betaproteobacteria,44UYF@713636|Nitrosomonadales	28216|Betaproteobacteria	J	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs	rnr	-	-	ko:K12573	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	OB_RNB,RNB,S1
HKD3_k127_8502985_23	375286.mma_2116	3.151e-62	222.0	COG2236@1|root,COG2236@2|Bacteria,1R675@1224|Proteobacteria,2VPZG@28216|Betaproteobacteria,4745R@75682|Oxalobacteraceae	28216|Betaproteobacteria	F	Phosphoribosyl transferase domain	gpt	-	-	ko:K07101	-	-	-	-	ko00000	-	-	-	Pribosyltran
HKD3_k127_8502985_7	1123399.AQVE01000002_gene2427	1.286e-167	545.0	COG0104@1|root,COG0104@2|Bacteria,1MU5B@1224|Proteobacteria,1RNEW@1236|Gammaproteobacteria,45ZQU@72273|Thiotrichales	72273|Thiotrichales	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	-	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
HKD3_k127_8502985_14	522306.CAP2UW1_2912	9.141e-107	355.0	COG3705@1|root,COG3705@2|Bacteria,1MWIG@1224|Proteobacteria,2VHVX@28216|Betaproteobacteria,1KPU5@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	E	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine	hisZ	-	-	ko:K02502	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002	-	-	-	tRNA-synt_His
HKD3_k127_8502985_31	1163617.SCD_n01798	3.635e-16	79.0	COG3242@1|root,COG3242@2|Bacteria,1NG9Q@1224|Proteobacteria,2VXNJ@28216|Betaproteobacteria	28216|Betaproteobacteria	S	protein conserved in bacteria	-	-	-	ko:K09937	-	-	-	-	ko00000	-	-	-	DUF2065
HKD3_k127_8502985_15	522306.CAP2UW1_2914	1.898e-104	349.0	COG0330@1|root,COG0330@2|Bacteria,1MV7R@1224|Proteobacteria,2VI9W@28216|Betaproteobacteria,1KQ7P@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	O	HflC and HflK could regulate a protease	hflC	-	-	ko:K04087	-	M00742	-	-	ko00000,ko00002,ko01000	-	-	-	Band_7
HKD3_k127_8502985_10	1288494.EBAPG3_4030	2.064e-149	502.0	COG0330@1|root,COG0330@2|Bacteria,1MUM2@1224|Proteobacteria,2VIG2@28216|Betaproteobacteria,371ZU@32003|Nitrosomonadales	28216|Betaproteobacteria	O	HflC and HflK could encode or regulate a protease	hflK	-	-	ko:K04088	-	M00742	-	-	ko00000,ko00002,ko01000	-	-	-	Band_7,HflK_N
HKD3_k127_8502985_12	748247.AZKH_0812	1.004e-131	433.0	COG2262@1|root,COG2262@2|Bacteria,1MUA0@1224|Proteobacteria,2VI86@28216|Betaproteobacteria,2KV0C@206389|Rhodocyclales	206389|Rhodocyclales	S	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis	hflX	-	-	ko:K03665	-	-	-	-	ko00000,ko03009	-	-	-	GTP-bdg_M,GTP-bdg_N,MMR_HSR1
HKD3_k127_8502985_28	1121004.ATVC01000020_gene40	7.483e-37	144.0	COG1923@1|root,COG1923@2|Bacteria,1MZM1@1224|Proteobacteria,2VTXK@28216|Betaproteobacteria,2KRCS@206351|Neisseriales	206351|Neisseriales	J	RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs	hfq	-	-	ko:K03666	ko02024,ko03018,ko05111,map02024,map03018,map05111	-	-	-	ko00000,ko00001,ko03019,ko03036	-	-	-	Hfq
HKD3_k127_8502985_6	1286093.C266_17771	1.818e-185	594.0	COG1160@1|root,COG1160@2|Bacteria,1MU9S@1224|Proteobacteria,2VI8D@28216|Betaproteobacteria,1K2BU@119060|Burkholderiaceae	28216|Betaproteobacteria	S	GTPase that plays an essential role in the late steps of ribosome biogenesis	der	-	-	ko:K03977	-	-	-	-	ko00000,ko03009	-	-	-	KH_dom-like,MMR_HSR1
HKD3_k127_8502985_17	1163617.SCD_n01806	1.315e-99	344.0	COG1520@1|root,COG1520@2|Bacteria,1MXIJ@1224|Proteobacteria,2VHH5@28216|Betaproteobacteria	28216|Betaproteobacteria	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamB	-	-	ko:K17713	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	PQQ_2,PQQ_3
HKD3_k127_8502985_24	1163617.SCD_n01807	4.591e-62	223.0	COG2976@1|root,COG2976@2|Bacteria,1N117@1224|Proteobacteria,2VSHE@28216|Betaproteobacteria	28216|Betaproteobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	TPR_21
HKD3_k127_8502985_8	265072.Mfla_1619	5.362e-160	535.0	COG0124@1|root,COG0124@2|Bacteria,1MV2K@1224|Proteobacteria,2VIGA@28216|Betaproteobacteria,2KKZY@206350|Nitrosomonadales	206350|Nitrosomonadales	J	PFAM tRNA synthetase class II (G H P and S)	hisS	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
HKD3_k127_8502985_4	292415.Tbd_0594	1.477e-198	628.0	COG0821@1|root,COG0821@2|Bacteria,1MUAX@1224|Proteobacteria,2VID7@28216|Betaproteobacteria,1KREF@119069|Hydrogenophilales	119069|Hydrogenophilales	I	GcpE protein	ispG	-	1.17.7.1,1.17.7.3	ko:K03526	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R08689,R10859	RC01486	ko00000,ko00001,ko00002,ko01000	-	-	-	GcpE
HKD3_k127_8502985_27	62928.azo0926	4.804e-39	159.0	COG1426@1|root,COG1426@2|Bacteria,1N240@1224|Proteobacteria,2VVFV@28216|Betaproteobacteria,2KWMY@206389|Rhodocyclales	206389|Rhodocyclales	S	Domain of unknown function (DUF4115)	-	-	-	ko:K15539	-	-	-	-	ko00000	-	-	-	DUF4115,HTH_25
HKD3_k127_8502985_32	640081.Dsui_3144	1.888e-06	50.0	COG3063@1|root,COG3063@2|Bacteria,1MXPC@1224|Proteobacteria,2VNC8@28216|Betaproteobacteria,2KW79@206389|Rhodocyclales	206389|Rhodocyclales	NU	type 4 pilus biogenesis protein	pilF	-	-	ko:K02656	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	TPR_16,TPR_2,TPR_8
HKD3_k127_8576355_4	1125863.JAFN01000001_gene663	2.436e-282	885.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1149@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1149@2|Bacteria,1MVM0@1224|Proteobacteria,42MZ0@68525|delta/epsilon subdivisions,2WJ96@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	poR	-	1.2.7.1	ko:K03737	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00173,M00307	R01196,R10866	RC00004,RC02742	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	EKR,Fer4_16,PFOR_II,POR,POR_N,TPP_enzyme_C
HKD3_k127_8576355_26	404589.Anae109_2748	1.617e-80	302.0	COG0493@1|root,COG0543@1|root,COG1633@1|root,COG0493@2|Bacteria,COG0543@2|Bacteria,COG1633@2|Bacteria,1MU2H@1224|Proteobacteria,42MGY@68525|delta/epsilon subdivisions,2WJHC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	TIGRFAM glutamate synthase (NADPH), homotetrameric	nfnA	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	DHODB_Fe-S_bind,Fer4_20,Pyr_redox_2
HKD3_k127_8576355_0	290397.Adeh_2791	0.0	1266.0	COG0493@1|root,COG0543@1|root,COG1633@1|root,COG0493@2|Bacteria,COG0543@2|Bacteria,COG1633@2|Bacteria,1MU2H@1224|Proteobacteria,42MGY@68525|delta/epsilon subdivisions,2WKB4@28221|Deltaproteobacteria,2YTUD@29|Myxococcales	28221|Deltaproteobacteria	C	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	-	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4_20,Pyr_redox_2
HKD3_k127_8576355_22	765914.ThisiDRAFT_1965	8.778e-93	314.0	COG2009@1|root,2ZBTX@2|Bacteria,1RB22@1224|Proteobacteria,1S4JK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	fumarate reductase respiratory complex transmembrane subunit	-	-	-	ko:K00246	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020	M00009,M00011,M00150,M00173	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	Sdh_cyt
HKD3_k127_8576355_2	469610.HMPREF0189_00997	0.0	1049.0	COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,2VHM6@28216|Betaproteobacteria,1KJ0V@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily	sdhA	-	1.3.5.1,1.3.5.4	ko:K00239,ko:K00244	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,ko05134,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020,map05134	M00009,M00011,M00149,M00150,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
HKD3_k127_8576355_18	765914.ThisiDRAFT_1963	2.589e-117	384.0	COG0479@1|root,COG0479@2|Bacteria,1MVHS@1224|Proteobacteria,1RSQ8@1236|Gammaproteobacteria,1WWKV@135613|Chromatiales	135613|Chromatiales	C	TIGRFAM Succinate dehydrogenase fumarate reductase iron-sulphur protein	-	-	1.3.5.1,1.3.5.4	ko:K00240	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_3,Fer4_8
HKD3_k127_8576355_43	207559.Dde_2046	4.638e-08	62.0	COG0517@1|root,COG0517@2|Bacteria,1QUKQ@1224|Proteobacteria,42TPD@68525|delta/epsilon subdivisions,2WQQ5@28221|Deltaproteobacteria,2MC2I@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	PFAM CBS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CBS
HKD3_k127_8576355_9	1430440.MGMSRv2_2156	7.179e-174	565.0	COG1055@1|root,COG1055@2|Bacteria,1MUX4@1224|Proteobacteria,2V6WW@28211|Alphaproteobacteria,2JRJU@204441|Rhodospirillales	204441|Rhodospirillales	P	Citrate transporter	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS
HKD3_k127_8576355_5	338969.Rfer_3846	1.387e-264	824.0	COG1027@1|root,COG1027@2|Bacteria,1R9JY@1224|Proteobacteria,2W02M@28216|Betaproteobacteria,4AD99@80864|Comamonadaceae	28216|Betaproteobacteria	E	Fumarate lyase	aspA	-	4.3.1.1	ko:K01744	ko00250,ko01100,map00250,map01100	-	R00490	RC00316,RC02799	ko00000,ko00001,ko01000	-	-	-	FumaraseC_C,Lyase_1
HKD3_k127_8576355_6	522306.CAP2UW1_3015	1.127e-242	754.0	COG2704@1|root,COG2704@2|Bacteria,1MVHH@1224|Proteobacteria,2VI3D@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane	-	-	-	ko:K07791,ko:K07792	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.13.1	-	-	DcuA_DcuB
HKD3_k127_8576355_32	224911.27353343	2.772e-57	216.0	COG3203@1|root,COG3203@2|Bacteria,1Q96Q@1224|Proteobacteria,2U9II@28211|Alphaproteobacteria,3K2DE@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	M	outer membrane porin, OprD family	-	-	-	-	-	-	-	-	-	-	-	-	OprD
HKD3_k127_8576355_28	339670.Bamb_6249	4.807e-67	252.0	COG0834@1|root,COG0834@2|Bacteria,1MXEJ@1224|Proteobacteria,2VIQK@28216|Betaproteobacteria,1JZZU@119060|Burkholderiaceae	28216|Betaproteobacteria	ET	Bacterial periplasmic substrate-binding proteins	-	-	-	ko:K10001	ko02010,ko02020,map02010,map02020	M00230	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3.19,3.A.1.3.4	-	-	SBP_bac_3
HKD3_k127_8576355_11	1217718.ALOU01000020_gene2128	4.035e-154	501.0	COG1301@1|root,COG1301@2|Bacteria,1MU0Q@1224|Proteobacteria,2VIZB@28216|Betaproteobacteria,1K222@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family	-	-	-	-	-	-	-	-	-	-	-	-	SDF
HKD3_k127_8576355_7	640511.BC1002_3528	6.622e-223	706.0	COG0471@1|root,COG0471@2|Bacteria,1MUSA@1224|Proteobacteria,2VJ9R@28216|Betaproteobacteria	28216|Betaproteobacteria	P	Transporter, DASS family	-	-	-	ko:K11106,ko:K14445	-	-	-	-	ko00000,ko02000	2.A.47.1,2.A.47.3.3	-	-	Na_sulph_symp
HKD3_k127_8576355_13	469610.HMPREF0189_00442	1.548e-149	490.0	COG0471@1|root,COG0471@2|Bacteria,1MUSA@1224|Proteobacteria,2VJ9R@28216|Betaproteobacteria,1KP92@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	Sodium:sulfate symporter transmembrane region	-	-	-	ko:K11106,ko:K14445	-	-	-	-	ko00000,ko02000	2.A.47.1,2.A.47.3.3	-	-	Na_sulph_symp
HKD3_k127_8576355_1	397945.Aave_1095	0.0	1132.0	COG0280@1|root,COG0281@1|root,COG0280@2|Bacteria,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,2VIYB@28216|Betaproteobacteria,4AA5S@80864|Comamonadaceae	28216|Betaproteobacteria	C	Phosphate acetyl butaryl transferase	maeB	-	1.1.1.40	ko:K00029	ko00620,ko00710,ko01100,ko01120,ko01200,map00620,map00710,map01100,map01120,map01200	M00169,M00172	R00216	RC00105	ko00000,ko00001,ko00002,ko01000	-	-	-	Malic_M,PTA_PTB,malic
HKD3_k127_8576355_17	1424334.W822_19640	5.628e-122	407.0	COG0329@1|root,COG0329@2|Bacteria,1MXM5@1224|Proteobacteria,2VIKK@28216|Betaproteobacteria,3T6I6@506|Alcaligenaceae	28216|Betaproteobacteria	EM	Belongs to the DapA family	-	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
HKD3_k127_8576355_35	28152.DJ57_174	2.233e-41	164.0	COG0730@1|root,COG0730@2|Bacteria,1MX4T@1224|Proteobacteria,1S132@1236|Gammaproteobacteria,41D8A@629|Yersinia	1236|Gammaproteobacteria	S	Sulfite exporter TauE/SafE	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
HKD3_k127_8576355_34	1223521.BBJX01000001_gene1059	9.551e-42	166.0	COG4319@1|root,COG4319@2|Bacteria,1QVWY@1224|Proteobacteria,2WH58@28216|Betaproteobacteria,4AEG6@80864|Comamonadaceae	28216|Betaproteobacteria	S	SnoaL-like domain	-	-	5.3.3.1	ko:K01822	ko00140,ko00984,ko01100,ko01120,map00140,map00984,map01100,map01120	M00107,M00110	R01837,R02216,R02499,R02840,R03327,R04163,R04678,R04849,R09955	RC00146,RC00762	ko00000,ko00001,ko00002,ko01000	-	-	-	SnoaL_2
HKD3_k127_8576355_25	62928.azo3315	1.103e-81	283.0	COG0300@1|root,COG0300@2|Bacteria,1R735@1224|Proteobacteria,2VH63@28216|Betaproteobacteria,2KW32@206389|Rhodocyclales	206389|Rhodocyclales	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HKD3_k127_8576355_31	358220.C380_23155	1.745e-57	223.0	2ANPA@1|root,31DNS@2|Bacteria,1RHTE@1224|Proteobacteria,2VRS4@28216|Betaproteobacteria,4ADSE@80864|Comamonadaceae	28216|Betaproteobacteria	S	Protein of unknown function (DUF3833)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3833
HKD3_k127_8576355_21	1000565.METUNv1_00297	5.897e-102	354.0	COG2211@1|root,COG2211@2|Bacteria,1MVUM@1224|Proteobacteria,2VI47@28216|Betaproteobacteria,2KVBH@206389|Rhodocyclales	206389|Rhodocyclales	G	MFS/sugar transport protein	-	-	-	-	-	-	-	-	-	-	-	-	MFS_2
HKD3_k127_8576355_36	420662.Mpe_A0233	5.729e-41	160.0	COG3572@1|root,COG3572@2|Bacteria,1N0R0@1224|Proteobacteria,2VUCP@28216|Betaproteobacteria,1KMBH@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	Chalcone isomerase-like	-	-	-	-	-	-	-	-	-	-	-	-	Chalcone_3
HKD3_k127_8576355_19	1454004.AW11_02101	2.144e-114	394.0	COG2230@1|root,COG2230@2|Bacteria,1MX3U@1224|Proteobacteria,2VJ00@28216|Betaproteobacteria,1KQAD@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	M	Mycolic acid cyclopropane synthetase	cfa	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008168,GO:0008610,GO:0008757,GO:0009058,GO:0009059,GO:0009273,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016741,GO:0019752,GO:0030312,GO:0032259,GO:0032787,GO:0034645,GO:0042546,GO:0043170,GO:0043436,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0070589,GO:0071554,GO:0071704,GO:0071766,GO:0071767,GO:0071768,GO:0071840,GO:0071944,GO:0072330,GO:1901576	2.1.1.79	ko:K00574	-	-	-	-	ko00000,ko01000	-	-	-	CMAS
HKD3_k127_8576355_27	243365.CV_3225	1.848e-76	269.0	COG3496@1|root,COG3496@2|Bacteria,1RC56@1224|Proteobacteria,2VIZ9@28216|Betaproteobacteria,2KQIZ@206351|Neisseriales	206351|Neisseriales	S	Protein of unknown function (DUF1365)	-	-	-	ko:K09701	-	-	-	-	ko00000	-	-	-	DUF1365
HKD3_k127_8576355_12	305700.B447_13044	2.376e-152	496.0	COG2907@1|root,COG2907@2|Bacteria,1MV4Z@1224|Proteobacteria,2VHCR@28216|Betaproteobacteria,2KVDS@206389|Rhodocyclales	206389|Rhodocyclales	S	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
HKD3_k127_8576355_20	85643.Tmz1t_1052	3.243e-103	343.0	COG1469@1|root,COG1469@2|Bacteria,1MV1B@1224|Proteobacteria,2VIC9@28216|Betaproteobacteria,2KVNT@206389|Rhodocyclales	206389|Rhodocyclales	S	Converts GTP to 7,8-dihydroneopterin triphosphate	-	-	3.5.4.16	ko:K01495,ko:K09007	ko00790,ko01100,map00790,map01100	M00126,M00841,M00842,M00843	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	-	GCHY-1
HKD3_k127_8576355_29	522306.CAP2UW1_3961	1.562e-64	230.0	COG0386@1|root,COG0386@2|Bacteria,1RDR8@1224|Proteobacteria,2VQHV@28216|Betaproteobacteria,1KQKZ@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	O	Glutathione peroxidase	-	-	1.11.1.9	ko:K00432	ko00480,ko00590,ko04918,map00480,map00590,map04918	-	R00274,R07034,R07035	RC00011,RC00982	ko00000,ko00001,ko01000	-	-	-	GSHPx
HKD3_k127_8576355_23	85643.Tmz1t_1049	9.297e-87	301.0	COG0789@1|root,COG5012@1|root,COG0789@2|Bacteria,COG5012@2|Bacteria,1R2NF@1224|Proteobacteria,2VJDG@28216|Betaproteobacteria,2KW35@206389|Rhodocyclales	206389|Rhodocyclales	K	B12 binding domain	-	-	-	ko:K22491	-	-	-	-	ko00000,ko03000	-	-	-	B12-binding,B12-binding_2,MerR_1
HKD3_k127_8576355_15	420662.Mpe_A0239	2.038e-142	455.0	COG1633@1|root,COG1633@2|Bacteria,1MXX8@1224|Proteobacteria,2VI3H@28216|Betaproteobacteria,1KJG3@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_8576355_37	1198452.Jab_1c22290	6.915e-40	161.0	COG1075@1|root,COG1075@2|Bacteria,1N3FV@1224|Proteobacteria,2WFKG@28216|Betaproteobacteria,4747N@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	PGAP1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6,Hydrolase_4,PGAP1
HKD3_k127_8576355_3	349521.HCH_04995	7.348e-285	889.0	COG3320@1|root,COG4221@1|root,COG3320@2|Bacteria,COG4221@2|Bacteria,1QSHC@1224|Proteobacteria,1RQP8@1236|Gammaproteobacteria,1XMDW@135619|Oceanospirillales	135619|Oceanospirillales	M	dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_4,adh_short
HKD3_k127_8576355_40	1265502.KB905938_gene2476	1.974e-27	119.0	COG3937@1|root,COG3937@2|Bacteria,1RIXG@1224|Proteobacteria,2VT1J@28216|Betaproteobacteria,4ADWD@80864|Comamonadaceae	28216|Betaproteobacteria	S	PFAM poly granule associated family protein	-	-	-	-	-	-	-	-	-	-	-	-	Phasin
HKD3_k127_8576355_41	357808.RoseRS_0103	2.086e-24	105.0	COG4281@1|root,COG4281@2|Bacteria,2G98T@200795|Chloroflexi,377KT@32061|Chloroflexia	32061|Chloroflexia	I	PFAM acyl-coA-binding protein, ACBP	-	-	-	-	-	-	-	-	-	-	-	-	ACBP
HKD3_k127_8576355_14	1384056.N787_00950	1.758e-147	484.0	COG1020@1|root,COG1020@2|Bacteria,1N7HY@1224|Proteobacteria,1S1HS@1236|Gammaproteobacteria,1X48P@135614|Xanthomonadales	135614|Xanthomonadales	Q	Protein of unknown function (DUF1298)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1298,WES_acyltransf
HKD3_k127_8576355_24	358220.C380_03055	1.069e-85	290.0	COG0457@1|root,COG0457@2|Bacteria,1R3PT@1224|Proteobacteria,2VN88@28216|Betaproteobacteria,4ACX0@80864|Comamonadaceae	28216|Betaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_8576355_30	522306.CAP2UW1_3345	6.517e-58	209.0	COG1309@1|root,COG1309@2|Bacteria,1R52P@1224|Proteobacteria,2VIDN@28216|Betaproteobacteria	28216|Betaproteobacteria	K	PFAM regulatory protein TetR	-	-	-	-	-	-	-	-	-	-	-	-	TetR,TetR_N
HKD3_k127_8576355_16	1454004.AW11_03509	1.911e-122	406.0	COG1752@1|root,COG1752@2|Bacteria,1R7RX@1224|Proteobacteria,2VMTI@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Patatin-like phospholipase	-	-	-	-	-	-	-	-	-	-	-	-	Patatin
HKD3_k127_8576355_8	1095769.CAHF01000022_gene391	3.745e-207	663.0	COG2303@1|root,COG2303@2|Bacteria,1P9UF@1224|Proteobacteria,2VHUP@28216|Betaproteobacteria,4723S@75682|Oxalobacteraceae	28216|Betaproteobacteria	E	GMC oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GMC_oxred_C,GMC_oxred_N
HKD3_k127_8576355_39	760117.JN27_15845	2.192e-34	139.0	2DQ04@1|root,33466@2|Bacteria,1NA4M@1224|Proteobacteria,2VTGQ@28216|Betaproteobacteria,474JJ@75682|Oxalobacteraceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	TAT_signal
HKD3_k127_8576355_33	522306.CAP2UW1_2233	6.715e-47	188.0	2AYXV@1|root,31R3M@2|Bacteria,1RHPG@1224|Proteobacteria,2VS4A@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_8576355_42	522306.CAP2UW1_3341	6.865e-13	83.0	2EGJT@1|root,33ABY@2|Bacteria,1NGI4@1224|Proteobacteria	1224|Proteobacteria	S	polyhydroxyalkanoic acid system protein	-	-	-	-	-	-	-	-	-	-	-	-	PHA_gran_rgn
HKD3_k127_8576355_10	1163617.SCD_n00075	3.655e-173	560.0	COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,2VI0U@28216|Betaproteobacteria	28216|Betaproteobacteria	I	Amp-dependent synthetase and ligase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
HKD3_k127_8576355_38	1223521.BBJX01000001_gene889	1.727e-36	143.0	COG1664@1|root,COG1664@2|Bacteria,1N26P@1224|Proteobacteria,2VSIS@28216|Betaproteobacteria,4AE27@80864|Comamonadaceae	28216|Betaproteobacteria	M	Polymer-forming cytoskeletal	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
HKD3_k127_8601063_0	1095769.CAHF01000021_gene941	4.086e-177	562.0	COG1653@1|root,COG1653@2|Bacteria,1MU64@1224|Proteobacteria	1224|Proteobacteria	G	Extracellular solute-binding protein	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1,SBP_bac_8
HKD3_k127_8623101_3	497321.C664_10957	5.482e-105	342.0	COG0443@1|root,COG0443@2|Bacteria,1MVEN@1224|Proteobacteria,2VH14@28216|Betaproteobacteria,2KVAY@206389|Rhodocyclales	206389|Rhodocyclales	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
HKD3_k127_8623101_5	1121035.AUCH01000002_gene1676	3.595e-49	182.0	COG0576@1|root,COG0576@2|Bacteria,1RH8T@1224|Proteobacteria,2VSEQ@28216|Betaproteobacteria,2KWC2@206389|Rhodocyclales	206389|Rhodocyclales	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	grpE	-	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
HKD3_k127_8623101_2	795666.MW7_2710	1.023e-125	414.0	COG0276@1|root,COG0276@2|Bacteria,1MVR1@1224|Proteobacteria,2VH7Z@28216|Betaproteobacteria,1K1UG@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Catalyzes the ferrous insertion into protoporphyrin IX	hemH	-	4.99.1.1,4.99.1.9	ko:K01772	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R00310,R11329	RC01012	ko00000,ko00001,ko00002,ko01000	-	-	-	Ferrochelatase
HKD3_k127_8623101_1	388051.AUFE01000014_gene6017	2.912e-134	435.0	COG1420@1|root,COG1420@2|Bacteria,1MVX4@1224|Proteobacteria,2VHCK@28216|Betaproteobacteria,1JZQY@119060|Burkholderiaceae	28216|Betaproteobacteria	K	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons	hrcA	-	-	ko:K03705	-	-	-	-	ko00000,ko03000	-	-	-	HrcA,HrcA_DNA-bdg
HKD3_k127_8623101_4	1144319.PMI16_03109	1.915e-86	295.0	COG0061@1|root,COG0061@2|Bacteria,1MUBC@1224|Proteobacteria,2VIV0@28216|Betaproteobacteria,472PK@75682|Oxalobacteraceae	28216|Betaproteobacteria	H	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	nadK	-	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	NAD_kinase
HKD3_k127_8623101_0	93220.LV28_09315	3.322e-151	496.0	COG0497@1|root,COG0497@2|Bacteria,1MUNP@1224|Proteobacteria,2VHHA@28216|Betaproteobacteria,1K174@119060|Burkholderiaceae	28216|Betaproteobacteria	L	May be involved in recombinational repair of damaged DNA	recN	-	-	ko:K03631	-	-	-	-	ko00000,ko03400	-	-	-	SMC_N
HKD3_k127_8623101_7	1242864.D187_005209	4.258e-22	111.0	COG0702@1|root,COG0702@2|Bacteria	2|Bacteria	GM	epimerase	-	-	1.1.1.219	ko:K00091	-	-	-	-	ko00000,ko01000	-	-	-	Epimerase,NAD_binding_10
HKD3_k127_8623101_8	1095769.CAHF01000022_gene149	4.705e-16	92.0	COG5569@1|root,COG5569@2|Bacteria,1N8CJ@1224|Proteobacteria,2VVSU@28216|Betaproteobacteria,47524@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Copper binding periplasmic protein CusF	-	-	-	-	-	-	-	-	-	-	-	-	CusF_Ec
HKD3_k127_8623101_6	1288494.EBAPG3_1530	2.314e-29	121.0	COG1686@1|root,COG1686@2|Bacteria,1MWZA@1224|Proteobacteria,2VH1S@28216|Betaproteobacteria,371XF@32003|Nitrosomonadales	28216|Betaproteobacteria	M	Beta-lactamase enzyme family	pbpG	-	-	ko:K07262	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_S11
HKD3_k127_8635771_5	1232410.KI421426_gene1460	3.025e-28	123.0	COG0628@1|root,COG0628@2|Bacteria,1MVX7@1224|Proteobacteria,42S7F@68525|delta/epsilon subdivisions,2WK0P@28221|Deltaproteobacteria,43T7X@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
HKD3_k127_8635771_1	1121033.AUCF01000006_gene4207	3.145e-154	498.0	COG1473@1|root,COG1473@2|Bacteria,1MUIV@1224|Proteobacteria,2TR5B@28211|Alphaproteobacteria,2JPY3@204441|Rhodospirillales	204441|Rhodospirillales	S	Psort location Cytoplasmic, score 7.50	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
HKD3_k127_8635771_0	1205680.CAKO01000030_gene4920	3.252e-171	551.0	COG0578@1|root,COG0578@2|Bacteria,1MUMY@1224|Proteobacteria,2TU11@28211|Alphaproteobacteria,2JQAF@204441|Rhodospirillales	204441|Rhodospirillales	C	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family	glpD	-	1.1.5.3	ko:K00111	ko00564,ko01110,map00564,map01110	-	R00848	RC00029	ko00000,ko00001,ko01000	-	-	-	DAO,DAO_C
HKD3_k127_8635771_3	1382359.JIAL01000001_gene1483	2.939e-54	198.0	COG1611@1|root,COG1611@2|Bacteria,3Y4RU@57723|Acidobacteria,2JJDD@204432|Acidobacteriia	204432|Acidobacteriia	S	Possible lysine decarboxylase	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
HKD3_k127_8635771_2	1380391.JIAS01000011_gene4626	1.034e-95	330.0	COG0561@1|root,COG0561@2|Bacteria,1R4WX@1224|Proteobacteria,2TSDR@28211|Alphaproteobacteria,2JVQ8@204441|Rhodospirillales	204441|Rhodospirillales	S	haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_3
HKD3_k127_8635771_4	358823.DF19_29335	6.752e-47	171.0	COG0148@1|root,COG0148@2|Bacteria,2GPC3@201174|Actinobacteria	201174|Actinobacteria	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	-	-	-	-	-	-	-	-	-	-	-	-	Enolase_C,Enolase_N
HKD3_k127_8641087_3	266264.Rmet_1540	1.48e-13	79.0	COG0309@1|root,COG0309@2|Bacteria,1MVCC@1224|Proteobacteria,2VH3K@28216|Betaproteobacteria,1K3J9@119060|Burkholderiaceae	28216|Betaproteobacteria	O	hydrogenase expression formation protein HypE	hypE	-	-	ko:K04655	-	-	-	-	ko00000	-	-	-	AIRS,AIRS_C
HKD3_k127_8641087_0	266264.Rmet_1539	7.726e-198	631.0	COG0409@1|root,COG0409@2|Bacteria,1MU1F@1224|Proteobacteria,2VHKM@28216|Betaproteobacteria,1K3JF@119060|Burkholderiaceae	28216|Betaproteobacteria	O	Belongs to the HypD family	hypD	-	-	ko:K04654	-	-	-	-	ko00000	-	-	-	HypD
HKD3_k127_8641087_2	497321.C664_15513	1.697e-29	118.0	COG0298@1|root,COG0298@2|Bacteria,1N76Y@1224|Proteobacteria,2VVZH@28216|Betaproteobacteria,2KX70@206389|Rhodocyclales	206389|Rhodocyclales	O	Hydrogenase assembly chaperone hypC hupF	hypC	-	-	ko:K04653	-	-	-	-	ko00000	-	-	-	HupF_HypC
HKD3_k127_8641087_1	62928.azo3801	2.443e-150	484.0	COG0068@1|root,COG0068@2|Bacteria,1MVP8@1224|Proteobacteria,2VHS4@28216|Betaproteobacteria,2KUF2@206389|Rhodocyclales	206389|Rhodocyclales	O	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide	hypF	-	-	ko:K04656	-	-	-	-	ko00000	-	-	-	Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF
HKD3_k127_8714073_0	1040983.AXAE01000023_gene23	3.725e-264	822.0	COG0459@1|root,COG0459@2|Bacteria,1PMNK@1224|Proteobacteria,2TTPT@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	-	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0016465,GO:0032991,GO:0044183,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051082,GO:0061077,GO:0101031,GO:1990220	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
HKD3_k127_8714073_9	665571.STHERM_c19020	4.306e-18	94.0	COG0517@1|root,COG0517@2|Bacteria,2J6JU@203691|Spirochaetes	203691|Spirochaetes	S	CBS domain	-	-	-	ko:K04767	-	-	-	-	ko00000	-	-	-	ACT,CBS
HKD3_k127_8714073_4	768671.ThimaDRAFT_2451	1.513e-141	483.0	COG0457@1|root,COG3710@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1S720@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	Adenylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	TPR_11,TPR_16,TPR_19,TPR_2,TPR_8,Trans_reg_C
HKD3_k127_8714073_8	526227.Mesil_0720	5.544e-55	207.0	COG1917@1|root,COG1917@2|Bacteria	2|Bacteria	L	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_8714073_2	1095769.CAHF01000007_gene1657	9.429e-194	616.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2VJJD@28216|Betaproteobacteria,478FD@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	CoA-transferase family III	-	-	2.8.3.16	ko:K07749	-	-	-	-	ko00000,ko01000	-	-	-	CoA_transf_3
HKD3_k127_8714073_5	94624.Bpet4354	5.648e-118	385.0	COG1024@1|root,COG1024@2|Bacteria,1MXBB@1224|Proteobacteria,2VICM@28216|Betaproteobacteria,3T393@506|Alcaligenaceae	28216|Betaproteobacteria	I	enoyl-CoA hydratase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
HKD3_k127_8714073_1	1007105.PT7_1571	3.713e-205	645.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2VHJP@28216|Betaproteobacteria	28216|Betaproteobacteria	G	TRAP C4-dicarboxylate transport system permease DctM subunit	-	-	-	-	-	-	-	-	-	-	-	-	DctM
HKD3_k127_8714073_7	1007105.PT7_1572	7.667e-57	204.0	COG3090@1|root,COG3090@2|Bacteria,1N0N7@1224|Proteobacteria	1224|Proteobacteria	G	COG3090 TRAP-type C4-dicarboxylate transport system small permease component	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
HKD3_k127_8714073_3	1007105.PT7_1573	1.231e-157	503.0	COG1638@1|root,COG1638@2|Bacteria,1MVHC@1224|Proteobacteria,2VHPJ@28216|Betaproteobacteria	28216|Betaproteobacteria	G	TIGRFAM TRAP dicarboxylate transporter, DctP subunit	-	-	-	-	-	-	-	-	-	-	-	-	DctP
HKD3_k127_8714073_6	94624.Bpet4350	2.225e-87	291.0	COG0075@1|root,COG0075@2|Bacteria,1MWHJ@1224|Proteobacteria,2VI9Q@28216|Betaproteobacteria,3T51C@506|Alcaligenaceae	28216|Betaproteobacteria	E	Serine-pyruvate aminotransferase archaeal aspartate aminotransferase	sgaA	-	2.6.1.44,2.6.1.45,2.6.1.51	ko:K00830	ko00250,ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko04146,map00250,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200,map04146	M00346,M00532	R00369,R00372,R00585,R00588	RC00006,RC00008,RC00018	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_5
HKD3_k127_8715606_3	1304883.KI912532_gene1759	2.718e-29	131.0	COG0122@1|root,COG0122@2|Bacteria,1MX9C@1224|Proteobacteria,2VHMQ@28216|Betaproteobacteria,2KX76@206389|Rhodocyclales	206389|Rhodocyclales	L	endonuclease III	-	-	3.2.2.21	ko:K01247	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
HKD3_k127_8715606_2	1485544.JQKP01000001_gene1325	5.785e-37	161.0	COG3216@1|root,COG3216@2|Bacteria,1RGV6@1224|Proteobacteria,2VSHR@28216|Betaproteobacteria,44VXR@713636|Nitrosomonadales	28216|Betaproteobacteria	S	Uncharacterized protein conserved in bacteria (DUF2062)	-	-	-	ko:K09928	-	-	-	-	ko00000	-	-	-	DUF2062
HKD3_k127_8715606_0	1005048.CFU_3176	8.58e-230	738.0	COG4166@1|root,COG4166@2|Bacteria,1R87R@1224|Proteobacteria,2VKFJ@28216|Betaproteobacteria,47408@75682|Oxalobacteraceae	28216|Betaproteobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_5
HKD3_k127_8715606_1	1005048.CFU_3178	4.666e-138	448.0	COG4166@1|root,COG4166@2|Bacteria,1R87R@1224|Proteobacteria,2VKFJ@28216|Betaproteobacteria,476HH@75682|Oxalobacteraceae	28216|Betaproteobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_5
HKD3_k127_8752823_0	1118058.CAGY01000001_gene597	1.328e-152	495.0	COG0114@1|root,COG0114@2|Bacteria,2GKWY@201174|Actinobacteria,4D3ID@85005|Actinomycetales	201174|Actinobacteria	C	Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate	fumC	-	4.2.1.2	ko:K01679	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211	M00009,M00011,M00173,M00376	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	FumaraseC_C,Lyase_1
HKD3_k127_8752823_1	29581.BW37_03361	7.484e-83	291.0	COG0477@1|root,COG2814@2|Bacteria,1R3YS@1224|Proteobacteria,2VQBS@28216|Betaproteobacteria,473XW@75682|Oxalobacteraceae	28216|Betaproteobacteria	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD3_k127_8752823_2	983917.RGE_46800	3.005e-72	252.0	COG4166@1|root,COG4166@2|Bacteria,1R87R@1224|Proteobacteria,2VKFJ@28216|Betaproteobacteria,1KJPX@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_5
HKD3_k127_8760026_6	319003.Bra1253DRAFT_06926	1.294e-62	218.0	COG0604@1|root,COG0604@2|Bacteria,1MWBD@1224|Proteobacteria,2TS3Z@28211|Alphaproteobacteria,3JR0C@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Zinc-binding dehydrogenase	qor	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
HKD3_k127_8760026_8	572477.Alvin_0738	2.75e-31	132.0	COG1993@1|root,COG1993@2|Bacteria,1RH30@1224|Proteobacteria,1S7XN@1236|Gammaproteobacteria,1WYP4@135613|Chromatiales	135613|Chromatiales	S	Uncharacterized ACR, COG1993	-	-	-	-	-	-	-	-	-	-	-	-	DUF190
HKD3_k127_8760026_7	666685.R2APBS1_2746	4.272e-40	152.0	COG0239@1|root,COG0239@2|Bacteria,1MZNH@1224|Proteobacteria,1S9GR@1236|Gammaproteobacteria,1X7EW@135614|Xanthomonadales	135614|Xanthomonadales	D	Important for reducing fluoride concentration in the cell, thus reducing its toxicity	crcB	-	-	ko:K06199	-	-	-	-	ko00000,ko02000	1.A.43.1,1.A.43.2,1.A.43.3	-	-	CRCB
HKD3_k127_8760026_9	1501230.ET33_35920	5.605e-24	104.0	COG4538@1|root,COG4538@2|Bacteria,1VZE9@1239|Firmicutes,4I0FW@91061|Bacilli,270ZM@186822|Paenibacillaceae	91061|Bacilli	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_2
HKD3_k127_8760026_2	66377.JOBH01000012_gene4425	1.624e-74	258.0	COG1917@1|root,COG1917@2|Bacteria,2IAI4@201174|Actinobacteria	201174|Actinobacteria	S	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_7
HKD3_k127_8760026_1	864051.BurJ1DRAFT_2117	1.528e-83	287.0	COG1028@1|root,COG1028@2|Bacteria,1MWB6@1224|Proteobacteria,2VIXS@28216|Betaproteobacteria,1KNH5@119065|unclassified Burkholderiales	28216|Betaproteobacteria	IQ	KR domain	-	-	1.1.1.100,1.1.1.47,1.1.1.69,1.3.1.28	ko:K00034,ko:K00046,ko:K00059,ko:K00216	ko00030,ko00061,ko00333,ko00780,ko01040,ko01053,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00030,map00061,map00333,map00780,map01040,map01053,map01100,map01110,map01120,map01130,map01200,map01212	M00083,M00572	R01505,R01520,R01521,R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00066,RC00117,RC00534	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HKD3_k127_8760026_0	999541.bgla_1g22620	7.178e-101	342.0	COG0524@1|root,COG0524@2|Bacteria,1MVG2@1224|Proteobacteria,2VKA3@28216|Betaproteobacteria,1K03V@119060|Burkholderiaceae	28216|Betaproteobacteria	G	PFAM PfkB domain protein	kdgK	-	2.7.1.45	ko:K00874	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00061,M00308,M00631	R01541	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PfkB
HKD3_k127_8760026_3	1411123.JQNH01000001_gene183	5.797e-70	246.0	COG0800@1|root,COG0800@2|Bacteria,1RD0T@1224|Proteobacteria,2U7AQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Aldolase	dgoA	-	4.1.2.21	ko:K01631	ko00052,ko01100,map00052,map01100	M00552	R01064	RC00307,RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldolase
HKD3_k127_8760026_4	426117.M446_4620	2.003e-68	244.0	COG3734@1|root,COG3734@2|Bacteria,1MWGX@1224|Proteobacteria,2TTG8@28211|Alphaproteobacteria,1JR6M@119045|Methylobacteriaceae	28211|Alphaproteobacteria	G	PFAM 2-keto-3-deoxy-galactonokinase	dgoK	-	2.7.1.58	ko:K00883	ko00052,ko01100,map00052,map01100	M00552	R03387	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	DGOK
HKD3_k127_8760026_5	1304883.KI912532_gene2680	4.637e-68	233.0	COG0314@1|root,COG0314@2|Bacteria,1RGUX@1224|Proteobacteria,2VRMG@28216|Betaproteobacteria,2KW54@206389|Rhodocyclales	206389|Rhodocyclales	H	Molybdopterin converting factor, large subunit	moaE	-	2.8.1.12	ko:K03635	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09395	RC02507	ko00000,ko00001,ko01000	-	-	-	MoaE
HKD3_k127_8771882_1	748247.AZKH_p0304	2.794e-267	832.0	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,2VHRB@28216|Betaproteobacteria,2KY9N@206389|Rhodocyclales	206389|Rhodocyclales	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD3_k127_8771882_5	748247.AZKH_p0303	2.612e-146	474.0	COG0845@1|root,COG0845@2|Bacteria,1MUG6@1224|Proteobacteria,2VH7G@28216|Betaproteobacteria,2KYHU@206389|Rhodocyclales	206389|Rhodocyclales	M	Biotin-lipoyl like	-	-	-	ko:K01993	-	-	-	-	ko00000	-	-	-	HlyD_D23
HKD3_k127_8771882_15	1095769.CAHF01000013_gene3400	9.449e-55	199.0	COG1309@1|root,COG1309@2|Bacteria,1MVQV@1224|Proteobacteria,2VK6A@28216|Betaproteobacteria,4743P@75682|Oxalobacteraceae	28216|Betaproteobacteria	K	Bacterial transcriptional repressor C-terminal	-	-	-	ko:K09017	-	-	-	-	ko00000,ko03000	-	-	-	TetR_C_11,TetR_N
HKD3_k127_8771882_2	867845.KI911784_gene2483	3.779e-257	804.0	COG2225@1|root,COG2225@2|Bacteria,2G63R@200795|Chloroflexi,374XP@32061|Chloroflexia	32061|Chloroflexia	H	TIGRFAM malate synthase A	-	-	2.3.3.9	ko:K01638	ko00620,ko00630,ko01100,ko01110,ko01120,ko01200,map00620,map00630,map01100,map01110,map01120,map01200	M00012	R00472	RC00004,RC00308,RC02747	ko00000,ko00001,ko00002,ko01000	-	-	-	Malate_synthase
HKD3_k127_8771882_10	1000565.METUNv1_01281	4.272e-87	295.0	COG0725@1|root,COG0725@2|Bacteria,1MVNA@1224|Proteobacteria,2VJEC@28216|Betaproteobacteria,2KU6S@206389|Rhodocyclales	206389|Rhodocyclales	P	Molybdenum ABC transporter periplasmic molybdate-binding protein	modA	-	-	ko:K02020	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.8	-	-	SBP_bac_11
HKD3_k127_8771882_8	1000565.METUNv1_01282	7.289e-89	298.0	COG4149@1|root,COG4149@2|Bacteria,1MUXR@1224|Proteobacteria,2VIZW@28216|Betaproteobacteria,2KUKC@206389|Rhodocyclales	206389|Rhodocyclales	P	COG4149 ABC-type molybdate transport system, permease component	modB	-	-	ko:K02018	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.8	-	-	BPD_transp_1
HKD3_k127_8771882_6	1000565.METUNv1_01283	7.968e-112	394.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2WGQX@28216|Betaproteobacteria,2KZWD@206389|Rhodocyclales	206389|Rhodocyclales	E	ATPases associated with a variety of cellular activities	-	-	3.6.3.30	ko:K02010	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.10	-	-	ABC_tran
HKD3_k127_8771882_3	1205680.CAKO01000002_gene2615	7.235e-235	743.0	COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,2TSCJ@28211|Alphaproteobacteria,2JPC4@204441|Rhodospirillales	204441|Rhodospirillales	E	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)	leuA	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
HKD3_k127_8771882_17	1114970.PSF113_2074	4.773e-50	203.0	COG1807@1|root,COG1807@2|Bacteria,1QS61@1224|Proteobacteria,1RVHR@1236|Gammaproteobacteria,1YU16@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	M	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_8771882_7	640081.Dsui_3525	1.333e-97	329.0	COG1183@1|root,COG1183@2|Bacteria,1MWD9@1224|Proteobacteria,2VIME@28216|Betaproteobacteria,2KUY1@206389|Rhodocyclales	206389|Rhodocyclales	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pssA	-	2.7.8.8	ko:K17103	ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110	M00093	R01800	RC00002,RC00017,RC02795	ko00000,ko00001,ko00002,ko01000	-	-	-	CDP-OH_P_transf
HKD3_k127_8771882_11	76114.ebA7135	5.303e-87	294.0	COG0688@1|root,COG0688@2|Bacteria,1MW45@1224|Proteobacteria,2VHHT@28216|Betaproteobacteria,2KV8H@206389|Rhodocyclales	206389|Rhodocyclales	I	Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer)	psd	-	4.1.1.65	ko:K01613	ko00564,ko01100,ko01110,map00564,map01100,map01110	M00093	R02055	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	PS_Dcarbxylase
HKD3_k127_8771882_4	426114.THI_2486	3.501e-175	582.0	COG0059@1|root,COG0059@2|Bacteria,1MV7M@1224|Proteobacteria,2VIQ5@28216|Betaproteobacteria,1KIUF@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate	ilvC	-	1.1.1.86	ko:K00053	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R03051,R04439,R04440,R05068,R05069,R05071	RC00726,RC00836,RC00837,RC01726	ko00000,ko00001,ko00002,ko01000	-	-	-	IlvC,IlvN
HKD3_k127_8771882_13	323848.Nmul_A0473	8.483e-80	268.0	COG0440@1|root,COG0440@2|Bacteria,1RAGN@1224|Proteobacteria,2VH1H@28216|Betaproteobacteria,3730Y@32003|Nitrosomonadales	28216|Betaproteobacteria	E	TIGRFAM Acetolactate synthase, small subunit	ilvH	GO:0003674,GO:0003824,GO:0003984,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005948,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016053,GO:0016740,GO:0016744,GO:0019752,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494,GO:1990234	2.2.1.6	ko:K01653	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT_5,ALS_ss_C
HKD3_k127_8771882_0	323848.Nmul_A0474	2.101e-312	967.0	COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,2VJ55@28216|Betaproteobacteria,372AD@32003|Nitrosomonadales	28216|Betaproteobacteria	H	TIGRFAM Acetolactate synthase, large subunit, biosynthetic	ilvI	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
HKD3_k127_8771882_14	159087.Daro_3076	1.499e-72	252.0	COG1595@1|root,COG1595@2|Bacteria,1R9WC@1224|Proteobacteria,2VQ28@28216|Betaproteobacteria,2KW6F@206389|Rhodocyclales	206389|Rhodocyclales	K	Sigma-70, region 4	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD3_k127_8771882_19	76114.ebA7126	3.458e-27	124.0	2E3UK@1|root,32YRY@2|Bacteria,1N74J@1224|Proteobacteria,2VVQ2@28216|Betaproteobacteria,2KX7S@206389|Rhodocyclales	206389|Rhodocyclales	S	Protein of unknown function (DUF3106)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3106
HKD3_k127_8771882_20	1121127.JAFA01000016_gene3117	4.125e-19	94.0	COG1714@1|root,COG1714@2|Bacteria,1REEC@1224|Proteobacteria,2VRE0@28216|Betaproteobacteria,1K0CS@119060|Burkholderiaceae	28216|Betaproteobacteria	S	PFAM RDD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	RDD
HKD3_k127_8771882_12	62928.azo0573	6.911e-83	284.0	COG0697@1|root,COG0697@2|Bacteria,1MXCD@1224|Proteobacteria,2VMQB@28216|Betaproteobacteria,2KUKE@206389|Rhodocyclales	206389|Rhodocyclales	EG	COG0697 Permeases of the drug metabolite transporter (DMT) superfamily	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HKD3_k127_8771882_9	1163617.SCD_n01886	2.438e-87	291.0	COG0221@1|root,COG0221@2|Bacteria,1RA2F@1224|Proteobacteria,2VQC0@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions	ppa	-	3.6.1.1	ko:K01507	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyrophosphatase
HKD3_k127_8771882_18	639283.Snov_2774	3.191e-48	186.0	COG1802@1|root,COG1802@2|Bacteria,1MY2M@1224|Proteobacteria,2TTYE@28211|Alphaproteobacteria,3F0Q1@335928|Xanthobacteraceae	28211|Alphaproteobacteria	K	regulatory protein GntR HTH	MA20_06790	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
HKD3_k127_8771882_16	639283.Snov_2769	1.208e-54	206.0	COG0663@1|root,COG0663@2|Bacteria,1R511@1224|Proteobacteria,2U3I6@28211|Alphaproteobacteria,3F0NH@335928|Xanthobacteraceae	28211|Alphaproteobacteria	S	Bacterial transferase hexapeptide (six repeats)	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep
HKD3_k127_8924238_1	1123392.AQWL01000003_gene404	8.267e-90	303.0	COG0294@1|root,COG0294@2|Bacteria,1MUIR@1224|Proteobacteria,2VH2Q@28216|Betaproteobacteria,1KS4E@119069|Hydrogenophilales	119069|Hydrogenophilales	H	Pterin binding enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Pterin_bind
HKD3_k127_8924238_2	189753.AXAS01000075_gene6004	2.99e-82	287.0	COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,2TSG1@28211|Alphaproteobacteria,3JSYZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
HKD3_k127_8924238_0	1158292.JPOE01000002_gene1444	1.441e-143	459.0	COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,2VHEV@28216|Betaproteobacteria,1KJGN@119065|unclassified Burkholderiales	28216|Betaproteobacteria	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009056,GO:0009057,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019538,GO:0030163,GO:0042623,GO:0042802,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
HKD3_k127_8943645_1	383372.Rcas_3031	3.272e-153	493.0	COG3875@1|root,COG3875@2|Bacteria,2G8B3@200795|Chloroflexi	200795|Chloroflexi	S	Domain of unknown function (DUF2088)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2088
HKD3_k127_8943645_2	1037409.BJ6T_87360	5.773e-41	164.0	COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,2TSG1@28211|Alphaproteobacteria,3JSYZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
HKD3_k127_8943645_0	1458427.BAWN01000018_gene1140	5.161e-236	740.0	COG1350@1|root,COG1350@2|Bacteria,1N07Y@1224|Proteobacteria,2VJ62@28216|Betaproteobacteria,4ACES@80864|Comamonadaceae	28216|Betaproteobacteria	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	-	-	4.2.1.20	ko:K01696,ko:K06001	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HKD3_k127_896965_3	1286093.C266_03058	1.619e-27	118.0	COG2138@1|root,COG2138@2|Bacteria,1N00J@1224|Proteobacteria,2VTXE@28216|Betaproteobacteria,1K8IB@119060|Burkholderiaceae	28216|Betaproteobacteria	S	PFAM cobalamin (vitamin B12) biosynthesis CbiX protein	cbiX	-	4.99.1.3	ko:K03795	ko00860,ko01100,ko01120,map00860,map01100,map01120	-	R05807	RC01012	ko00000,ko00001,ko01000	-	-	-	CbiX
HKD3_k127_896965_1	331869.BAL199_05944	8.801e-54	199.0	COG0494@1|root,COG0494@2|Bacteria,1RD2C@1224|Proteobacteria,2TV3Q@28211|Alphaproteobacteria,4BQP3@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	L	NUDIX domain	MA20_44635	-	-	-	-	-	-	-	-	-	-	-	NUDIX
HKD3_k127_896965_0	1123367.C666_09375	4.202e-96	323.0	COG0596@1|root,COG0596@2|Bacteria,1MVVX@1224|Proteobacteria,2VH81@28216|Betaproteobacteria,2KVGE@206389|Rhodocyclales	206389|Rhodocyclales	S	hydrolases or acyltransferases (alpha beta hydrolase superfamily)	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
HKD3_k127_896965_2	1163617.SCD_n00828	2.523e-37	159.0	2C2C7@1|root,2Z85G@2|Bacteria,1PD07@1224|Proteobacteria,2VSBD@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_8984741_0	234267.Acid_1683	6.548e-71	259.0	COG0714@1|root,COG0714@2|Bacteria	2|Bacteria	KLT	Associated with various cellular activities	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3,AAA_5
HKD3_k127_9019573_15	1276756.AUEX01000021_gene3303	1.908e-19	89.0	COG0583@1|root,COG0583@2|Bacteria,1MWVU@1224|Proteobacteria,2VJJH@28216|Betaproteobacteria,4ACPS@80864|Comamonadaceae	28216|Betaproteobacteria	K	Transcriptional regulator, LysR family	-	-	-	ko:K21703	-	-	-	-	ko00000,ko03000	-	-	-	HTH_1,LysR_substrate
HKD3_k127_9019573_8	640081.Dsui_0746	2.94e-123	402.0	COG0189@1|root,COG0189@2|Bacteria,1MVUA@1224|Proteobacteria,2VIZ3@28216|Betaproteobacteria,2KUJJ@206389|Rhodocyclales	206389|Rhodocyclales	H	Belongs to the prokaryotic GSH synthase family	gshB	-	6.3.2.3	ko:K01920	ko00270,ko00480,ko01100,map00270,map00480,map01100	M00118	R00497,R10994	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	GSH-S_ATP,GSH-S_N
HKD3_k127_9019573_13	1123367.C666_13380	2.093e-45	168.0	COG2893@1|root,COG2893@2|Bacteria,1RHH7@1224|Proteobacteria,2VT9I@28216|Betaproteobacteria,2KWTC@206389|Rhodocyclales	206389|Rhodocyclales	G	Phosphotransferase system, mannose fructose-specific component IIA	ptsL	-	2.7.1.194	ko:K02821	ko00053,ko01100,ko01120,ko02060,map00053,map01100,map01120,map02060	M00283,M00550	R07671	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.7.1	-	-	EIIA-man
HKD3_k127_9019573_14	580332.Slit_0104	2.701e-34	135.0	COG1925@1|root,COG1925@2|Bacteria,1N6RM@1224|Proteobacteria,2VU8W@28216|Betaproteobacteria,44VZQ@713636|Nitrosomonadales	28216|Betaproteobacteria	G	PTS HPr component phosphorylation site	ptsH	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K11189	-	-	-	-	ko00000,ko02000	4.A.2.1	-	-	PTS-HPr
HKD3_k127_9019573_17	1123392.AQWL01000005_gene3160	1.071e-16	85.0	COG1925@1|root,COG1925@2|Bacteria,1N6RM@1224|Proteobacteria,2VU8W@28216|Betaproteobacteria,1KRUF@119069|Hydrogenophilales	119069|Hydrogenophilales	G	PTS HPr component phosphorylation site	-	-	-	-	-	-	-	-	-	-	-	-	PTS-HPr
HKD3_k127_9019573_1	1288494.EBAPG3_5570	1.568e-230	729.0	COG1080@1|root,COG1080@2|Bacteria,1MUT8@1224|Proteobacteria,2VH9N@28216|Betaproteobacteria,371S3@32003|Nitrosomonadales	28216|Betaproteobacteria	G	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)	ptsI	-	2.7.3.9	ko:K08483	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	8.A.7	-	-	PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C
HKD3_k127_9019573_4	937774.TEQUI_0452	4.575e-212	675.0	COG0500@1|root,COG2021@1|root,COG2021@2|Bacteria,COG2226@2|Bacteria,1MVJV@1224|Proteobacteria,2VHU9@28216|Betaproteobacteria,3T1KJ@506|Alcaligenaceae	28216|Betaproteobacteria	E	Transfers a succinyl group from succinyl-CoA to L- homoserine, forming succinyl-L-homoserine	metXS	-	2.3.1.31	ko:K00641	ko00270,ko01100,ko01130,map00270,map01100,map01130	-	R01776	RC00004,RC00041	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1
HKD3_k127_9019573_7	1163617.SCD_n00089	4.743e-185	595.0	COG2270@1|root,COG2270@2|Bacteria,1QUVA@1224|Proteobacteria,2WHTQ@28216|Betaproteobacteria	28216|Betaproteobacteria	S	AmpG muropeptide MFS transporter K08218	-	-	-	ko:K08218	ko01501,map01501	M00628	-	-	ko00000,ko00001,ko00002,ko02000	2.A.1.25	-	-	MFS_1
HKD3_k127_9019573_11	485913.Krac_3792	2.197e-65	232.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_12,Methyltransf_23,Methyltransf_25,Methyltransf_31
HKD3_k127_9019573_3	279714.FuraDRAFT_1766	6.655e-215	686.0	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,2VHGH@28216|Betaproteobacteria,2KPUY@206351|Neisseriales	206351|Neisseriales	S	ABC transporter	-	-	-	ko:K06158	-	-	-	-	ko00000,ko03012	-	-	-	ABC_tran,ABC_tran_Xtn
HKD3_k127_9019573_9	1266925.JHVX01000005_gene2020	5.499e-107	352.0	COG0708@1|root,COG0708@2|Bacteria,1MVII@1224|Proteobacteria,2VI74@28216|Betaproteobacteria,372JW@32003|Nitrosomonadales	28216|Betaproteobacteria	L	Exodeoxyribonuclease III xth	exoA	-	3.1.11.2	ko:K01142	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exo_endo_phos
HKD3_k127_9019573_12	1532557.JL37_22315	5.622e-64	251.0	COG3264@1|root,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,2VJTH@28216|Betaproteobacteria	28216|Betaproteobacteria	M	mechanosensitive ion channel	-	-	-	ko:K05802	-	-	-	-	ko00000,ko02000	1.A.23.1.1	-	-	MS_channel
HKD3_k127_9019573_10	640081.Dsui_0873	1.274e-85	293.0	COG0461@1|root,COG0461@2|Bacteria,1MW6F@1224|Proteobacteria,2VH9U@28216|Betaproteobacteria,2KUYU@206389|Rhodocyclales	206389|Rhodocyclales	F	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)	pyrE	-	2.4.2.10	ko:K00762	ko00240,ko01100,map00240,map01100	M00051	R01870	RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran
HKD3_k127_9019573_16	1163617.SCD_n00093	7.618e-19	96.0	2DPC5@1|root,331GN@2|Bacteria,1NCRC@1224|Proteobacteria,2VVUT@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Domain of unknown function (DUF4124)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4124
HKD3_k127_9019573_0	762966.HMPREF9439_01863	9.406e-293	905.0	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,2VHES@28216|Betaproteobacteria,4PQKW@995019|Sutterellaceae	28216|Betaproteobacteria	S	ABC transporter	yjjK	-	3.6.3.25	ko:K06020	-	-	-	-	ko00000,ko01000	-	-	-	ABC_tran,ABC_tran_Xtn
HKD3_k127_9019573_6	1458357.BG58_13295	3.02e-199	635.0	COG4623@1|root,COG4623@2|Bacteria,1MWDS@1224|Proteobacteria,2VKSN@28216|Betaproteobacteria,1K51A@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_3,SLT
HKD3_k127_9019573_2	1163617.SCD_n00094	5.973e-220	693.0	COG0064@1|root,COG0064@2|Bacteria,1MUKG@1224|Proteobacteria,2VI3A@28216|Betaproteobacteria	28216|Betaproteobacteria	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatB	-	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	GatB_N,GatB_Yqey
HKD3_k127_9019573_5	76114.ebA3030	1.302e-211	666.0	COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,2VIG3@28216|Betaproteobacteria,2KUD1@206389|Rhodocyclales	206389|Rhodocyclales	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
HKD3_k127_9203859_1	1449351.RISW2_10800	2.498e-215	685.0	COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,2TSB1@28211|Alphaproteobacteria,4KKKQ@93682|Roseivivax	28211|Alphaproteobacteria	EH	Belongs to the TPP enzyme family	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
HKD3_k127_9203859_0	748247.AZKH_p0290	8.586e-216	690.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2VH80@28216|Betaproteobacteria,2KW5T@206389|Rhodocyclales	206389|Rhodocyclales	IQ	COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
HKD3_k127_9340280_9	595537.Varpa_5500	7.11e-13	72.0	29V5H@1|root,30GJ5@2|Bacteria,1PHC8@1224|Proteobacteria,2VRT9@28216|Betaproteobacteria,4AIAH@80864|Comamonadaceae	28216|Betaproteobacteria	S	Protein of unknown function (DUF3617)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3617
HKD3_k127_9340280_1	391038.Bphy_4353	6.203e-234	741.0	COG2079@1|root,COG2079@2|Bacteria,1MUIG@1224|Proteobacteria,2VH7T@28216|Betaproteobacteria,1K4ZW@119060|Burkholderiaceae	28216|Betaproteobacteria	S	2-methylcitrate dehydratase	prpD	-	4.2.1.79	ko:K01720	ko00640,map00640	-	R04424	RC01152	ko00000,ko00001,ko01000	-	-	-	MmgE_PrpD
HKD3_k127_9340280_4	765912.Thimo_0240	1.849e-110	367.0	COG2301@1|root,COG2301@2|Bacteria,1QDT5@1224|Proteobacteria,1RQI7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Belongs to the HpcH HpaI aldolase family	-	-	4.1.3.34	ko:K01644	ko02020,map02020	-	R00362	RC00067,RC01118	ko00000,ko00001,ko01000	-	-	-	HpcH_HpaI
HKD3_k127_9340280_2	1123253.AUBD01000007_gene721	7.361e-171	542.0	COG0039@1|root,COG0039@2|Bacteria,1MV57@1224|Proteobacteria,1RMAX@1236|Gammaproteobacteria,1X3NI@135614|Xanthomonadales	135614|Xanthomonadales	C	Catalyzes the reversible oxidation of malate to oxaloacetate	mdh	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006107,GO:0006108,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009060,GO:0009117,GO:0009987,GO:0015980,GO:0016491,GO:0016614,GO:0016615,GO:0016616,GO:0016999,GO:0017144,GO:0019362,GO:0019637,GO:0019674,GO:0019752,GO:0030060,GO:0034641,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044464,GO:0045333,GO:0046483,GO:0046496,GO:0051186,GO:0055086,GO:0055114,GO:0071704,GO:0072350,GO:0072524,GO:1901360,GO:1901564	1.1.1.37	ko:K00024	ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740	R00342,R07136	RC00031	ko00000,ko00001,ko00002,ko01000	-	-	-	Ldh_1_C,Ldh_1_N
HKD3_k127_9340280_5	1095769.CAHF01000011_gene2427	2.994e-84	286.0	COG2188@1|root,COG2188@2|Bacteria,1MUEB@1224|Proteobacteria,2VJ6N@28216|Betaproteobacteria,473MV@75682|Oxalobacteraceae	28216|Betaproteobacteria	K	UTRA	frlR	-	-	ko:K03710	-	-	-	-	ko00000,ko03000	-	-	-	GntR,UTRA
HKD3_k127_9340280_7	1000565.METUNv1_01114	1.557e-28	126.0	COG2009@1|root,COG2009@2|Bacteria,1RIGZ@1224|Proteobacteria,2VSEG@28216|Betaproteobacteria,2KWKD@206389|Rhodocyclales	206389|Rhodocyclales	C	COG2009 Succinate dehydrogenase fumarate reductase, cytochrome b subunit	-	-	-	ko:K00241	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	Sdh_cyt
HKD3_k127_9340280_6	1000565.METUNv1_01115	8.685e-34	137.0	COG2142@1|root,COG2142@2|Bacteria,1MZR9@1224|Proteobacteria,2VSJN@28216|Betaproteobacteria,2KWK5@206389|Rhodocyclales	206389|Rhodocyclales	C	Succinate dehydrogenase, hydrophobic	-	-	-	ko:K00242	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	Sdh_cyt
HKD3_k127_9340280_0	1095769.CAHF01000011_gene2424	5.44e-315	972.0	COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,2VHM6@28216|Betaproteobacteria,47361@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily	sdhA	GO:0000104,GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009055,GO:0009060,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016627,GO:0016999,GO:0017144,GO:0019752,GO:0022900,GO:0032991,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045273,GO:0045274,GO:0045281,GO:0045282,GO:0045333,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0072350,GO:0097159,GO:0098796,GO:0098797,GO:0098803,GO:1901265,GO:1901363,GO:1902494,GO:1990204	1.3.5.1,1.3.5.4	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
HKD3_k127_9340280_3	1288494.EBAPG3_15710	3.554e-132	426.0	COG0479@1|root,COG0479@2|Bacteria,1MVHS@1224|Proteobacteria,2VIKC@28216|Betaproteobacteria,372KC@32003|Nitrosomonadales	28216|Betaproteobacteria	C	succinate dehydrogenase fumarate reductase	sdhB	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0022900,GO:0022904,GO:0044237,GO:0044464,GO:0045333,GO:0048037,GO:0051536,GO:0051537,GO:0051538,GO:0051539,GO:0051540,GO:0055114,GO:0071944	1.3.5.1,1.3.5.4	ko:K00240	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_3,Fer4_17,Fer4_8
HKD3_k127_9340280_8	1288494.EBAPG3_15700	7.521e-15	79.0	COG2938@1|root,COG2938@2|Bacteria,1N7P4@1224|Proteobacteria,2VY7W@28216|Betaproteobacteria,373KF@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Flavinator of succinate dehydrogenase	-	-	-	ko:K09159	-	-	-	-	ko00000,ko02048	-	-	-	Sdh5
HKD3_k127_9431732_14	1297863.APJF01000001_gene2156	1.984e-26	111.0	COG2095@1|root,COG2095@2|Bacteria,1MX5T@1224|Proteobacteria,2VA2I@28211|Alphaproteobacteria,3JYVQ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	U	MarC family integral membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	MarC
HKD3_k127_9431732_7	1349767.GJA_1052	1.005e-112	391.0	COG2199@1|root,COG2199@2|Bacteria,1RKMU@1224|Proteobacteria,2WBGU@28216|Betaproteobacteria,475SJ@75682|Oxalobacteraceae	28216|Betaproteobacteria	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
HKD3_k127_9431732_9	84531.JMTZ01000020_gene3665	5.575e-81	293.0	COG2199@1|root,COG3706@2|Bacteria,1MZV7@1224|Proteobacteria,1RPR0@1236|Gammaproteobacteria,1X4VF@135614|Xanthomonadales	135614|Xanthomonadales	T	MASE2 domain	-	-	2.7.7.65	ko:K18968	ko02026,map02026	-	-	-	ko00000,ko00001,ko01000,ko02000	9.B.34.1.2	-	-	GGDEF,MASE2
HKD3_k127_9431732_15	33876.JNXY01000026_gene3430	1.913e-09	71.0	COG1167@1|root,COG1167@2|Bacteria,2I409@201174|Actinobacteria,4DMH5@85008|Micromonosporales	201174|Actinobacteria	K	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_33,GntR
HKD3_k127_9431732_11	1100720.ALKN01000035_gene961	6.285e-77	267.0	COG0500@1|root,COG0500@2|Bacteria,1QU8V@1224|Proteobacteria,2WGJ7@28216|Betaproteobacteria,4AHEN@80864|Comamonadaceae	28216|Betaproteobacteria	Q	Histone methylation protein DOT1	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25,Methyltransf_31
HKD3_k127_9431732_5	1100720.ALKN01000035_gene962	2.678e-135	445.0	COG0531@1|root,COG0531@2|Bacteria,1MXNJ@1224|Proteobacteria,2VMP7@28216|Betaproteobacteria	28216|Betaproteobacteria	E	amino acid	steT	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
HKD3_k127_9431732_0	323848.Nmul_A1150	0.0	1514.0	COG0493@1|root,COG0543@1|root,COG0493@2|Bacteria,COG0543@2|Bacteria,1PV5D@1224|Proteobacteria,2WB3J@28216|Betaproteobacteria,37281@32003|Nitrosomonadales	28216|Betaproteobacteria	CEH	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2
HKD3_k127_9431732_3	1205680.CAKO01000040_gene1070	4.995e-178	567.0	COG0683@1|root,COG0683@2|Bacteria,1MWNB@1224|Proteobacteria,2TTAH@28211|Alphaproteobacteria,2JQHT@204441|Rhodospirillales	204441|Rhodospirillales	E	Receptor family ligand binding region	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
HKD3_k127_9431732_2	596154.Alide2_0209	1.883e-215	686.0	COG0559@1|root,COG4177@1|root,COG0559@2|Bacteria,COG4177@2|Bacteria,1MY1E@1224|Proteobacteria,2VMZ5@28216|Betaproteobacteria,4AB9X@80864|Comamonadaceae	28216|Betaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997,ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HKD3_k127_9431732_10	1121033.AUCF01000005_gene5115	2.205e-77	291.0	COG0411@1|root,COG0411@2|Bacteria,1MUTY@1224|Proteobacteria,2TR6T@28211|Alphaproteobacteria,2JQUS@204441|Rhodospirillales	204441|Rhodospirillales	E	Branched-chain amino acid ATP-binding cassette transporter	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
HKD3_k127_9431732_4	1149133.ppKF707_2490	1.703e-141	468.0	COG0626@1|root,COG0626@2|Bacteria,1MU9E@1224|Proteobacteria,1RQI0@1236|Gammaproteobacteria,1YF63@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	E	Cys/Met metabolism PLP-dependent enzyme	metC	-	4.4.1.8	ko:K01760	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R00782,R01286,R02408,R04941	RC00056,RC00069,RC00382,RC00488,RC00710,RC01245,RC02303	ko00000,ko00001,ko00002,ko01000	-	-	-	Cys_Met_Meta_PP
HKD3_k127_9431732_13	316058.RPB_1888	3.78e-44	179.0	COG3265@1|root,COG3265@2|Bacteria,1RHD0@1224|Proteobacteria,2UBQX@28211|Alphaproteobacteria,3JUIV@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Shikimate kinase	-	-	2.7.1.12	ko:K00851	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200	-	R01737	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	AAA_33,SKI
HKD3_k127_9431732_6	1123368.AUIS01000009_gene2502	7.875e-127	412.0	COG1023@1|root,COG1023@2|Bacteria,1QU14@1224|Proteobacteria,1T1KM@1236|Gammaproteobacteria,2NBSK@225057|Acidithiobacillales	225057|Acidithiobacillales	G	6-phosphogluconate dehydrogenase, C-terminal domain	-	-	1.1.1.343,1.1.1.44	ko:K00033	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200	M00004,M00006	R01528,R10221	RC00001,RC00539	ko00000,ko00001,ko00002,ko01000	-	-	-	6PGD,NAD_binding_2
HKD3_k127_9431732_12	933262.AXAM01000003_gene2829	5.183e-52	195.0	COG0697@1|root,COG0697@2|Bacteria,1N469@1224|Proteobacteria,42QXU@68525|delta/epsilon subdivisions,2WN2T@28221|Deltaproteobacteria,2MJKS@213118|Desulfobacterales	28221|Deltaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HKD3_k127_9431732_1	365046.Rta_37590	3.341e-223	718.0	COG0174@1|root,COG0174@2|Bacteria,1MUGQ@1224|Proteobacteria,2WFJM@28216|Betaproteobacteria,4AD19@80864|Comamonadaceae	28216|Betaproteobacteria	E	Glutamine synthetase, catalytic domain	-	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C
HKD3_k127_9431732_8	296591.Bpro_4700	3.26e-94	315.0	COG1454@1|root,COG1454@2|Bacteria,1MVPH@1224|Proteobacteria,2VI90@28216|Betaproteobacteria,4AD0R@80864|Comamonadaceae	28216|Betaproteobacteria	C	Iron-containing alcohol dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Fe-ADH
HKD3_k127_966518_4	292415.Tbd_1702	3.16e-95	318.0	COG0805@1|root,COG0805@2|Bacteria,1MVAY@1224|Proteobacteria,2VI2H@28216|Betaproteobacteria,1KRBX@119069|Hydrogenophilales	119069|Hydrogenophilales	U	Sec-independent protein translocase protein (TatC)	-	-	-	ko:K03118	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	TatC
HKD3_k127_966518_10	640081.Dsui_1423	1.527e-27	117.0	COG1826@1|root,COG1826@2|Bacteria,1N73F@1224|Proteobacteria,2VVPX@28216|Betaproteobacteria,2KWT9@206389|Rhodocyclales	206389|Rhodocyclales	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation	tatB	-	-	ko:K03117	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
HKD3_k127_966518_11	228410.NE0639	6.944e-25	106.0	COG1826@1|root,COG1826@2|Bacteria,1N6S4@1224|Proteobacteria,2VVT6@28216|Betaproteobacteria,373M1@32003|Nitrosomonadales	28216|Betaproteobacteria	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system	tatA	-	-	ko:K03116	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
HKD3_k127_966518_8	1123367.C666_07280	3.162e-44	175.0	COG0537@1|root,COG0537@2|Bacteria,1RDCJ@1224|Proteobacteria,2VSMS@28216|Betaproteobacteria,2KWJU@206389|Rhodocyclales	206389|Rhodocyclales	FG	COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases	-	-	-	ko:K02503	-	-	-	-	ko00000,ko04147	-	-	-	DcpS_C,HIT
HKD3_k127_966518_12	550540.Fbal_1349	2.134e-15	87.0	2E74N@1|root,331P2@2|Bacteria,1RC0J@1224|Proteobacteria,1S2MI@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_966518_9	768671.ThimaDRAFT_3085	5.807e-35	136.0	COG0140@1|root,COG0140@2|Bacteria,1MZEE@1224|Proteobacteria,1S8R4@1236|Gammaproteobacteria,1WYHH@135613|Chromatiales	135613|Chromatiales	E	phosphoribosyl-ATP pyrophosphohydrolase	hisE	-	3.6.1.31	ko:K01523	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	PRA-PH
HKD3_k127_966518_7	713586.KB900536_gene2350	8.008e-56	198.0	COG0139@1|root,COG0139@2|Bacteria,1MW67@1224|Proteobacteria,1RMV4@1236|Gammaproteobacteria,1WYNT@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP	hisI	-	3.5.4.19	ko:K01496	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04037	RC01055	ko00000,ko00001,ko00002,ko01000	-	-	-	PRA-CH,PRA-PH
HKD3_k127_966518_3	1485544.JQKP01000011_gene772	2.479e-111	369.0	COG0107@1|root,COG0107@2|Bacteria,1MUS0@1224|Proteobacteria,2VHY0@28216|Betaproteobacteria,44VIE@713636|Nitrosomonadales	28216|Betaproteobacteria	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit	hisF	GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	-	ko:K02500	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
HKD3_k127_966518_2	76114.ebA1293	1.757e-123	401.0	COG0106@1|root,COG0106@2|Bacteria,1MW6S@1224|Proteobacteria,2VI38@28216|Betaproteobacteria,2KUM6@206389|Rhodocyclales	206389|Rhodocyclales	E	1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase	hisA	-	5.3.1.16	ko:K01814	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04640	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
HKD3_k127_966518_6	1304883.KI912532_gene1666	6.311e-87	291.0	COG0118@1|root,COG0118@2|Bacteria,1MU4X@1224|Proteobacteria,2VJPI@28216|Betaproteobacteria,2KUCS@206389|Rhodocyclales	206389|Rhodocyclales	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR	hisH	-	-	ko:K02501	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
HKD3_k127_966518_5	522306.CAP2UW1_4035	4.628e-92	321.0	COG0131@1|root,COG0131@2|Bacteria,1MWBS@1224|Proteobacteria,2VI59@28216|Betaproteobacteria,1KPX0@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	E	Imidazoleglycerol-phosphate dehydratase	hisB	-	4.2.1.19	ko:K01693	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R03457	RC00932	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPD
HKD3_k127_966518_1	279714.FuraDRAFT_0097	1.054e-126	416.0	COG0079@1|root,COG0079@2|Bacteria,1MW7I@1224|Proteobacteria,2VHX2@28216|Betaproteobacteria,2KQ7D@206351|Neisseriales	206351|Neisseriales	E	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily	hisC	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
HKD3_k127_966518_0	1123392.AQWL01000008_gene1201	2.894e-151	484.0	COG0141@1|root,COG0141@2|Bacteria,1MUUF@1224|Proteobacteria,2VJ7K@28216|Betaproteobacteria,1KS1T@119069|Hydrogenophilales	119069|Hydrogenophilales	E	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine	hisD	-	1.1.1.23	ko:K00013	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01158,R01163,R03012	RC00099,RC00242,RC00463	ko00000,ko00001,ko00002,ko01000	-	-	-	Histidinol_dh
## 2182 queries scanned
## Total time (seconds): 75.0488874912262
## Rate: 29.07 q/s