## Sat Nov 16 04:59:29 2024
## emapper-2.1.12
## /data/home/zkh/miniconda3/envs/eggnog-mapper/bin/emapper.py -i /data/home/zkh/binning/bin_4635/bin/bin9/HKD_3_bin.44.fa -m mmseqs --itype genome -o HKD_3_bin.44 --output_dir /data/home/zkh/meta_analysis/eggnog-mapper/4635/HKD_3_bin.44 --cpu 28
##
#query	seed_ortholog	evalue	score	eggNOG_OGs	max_annot_lvl	COG_category	Description	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	PFAMs
HKD3_k127_109424_20	1121288.AULL01000016_gene880	3.332e-22	106.0	2AC0T@1|root,311IM@2|Bacteria,4PGCB@976|Bacteroidetes,1IH7K@117743|Flavobacteriia,3ZT8H@59732|Chryseobacterium	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_109424_21	1385517.N800_06815	8.855e-10	67.0	2ET5N@1|root,311VW@2|Bacteria,1R3HC@1224|Proteobacteria,1T681@1236|Gammaproteobacteria,1XDI8@135614|Xanthomonadales	135614|Xanthomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_109424_6	240016.ABIZ01000001_gene4739	1.767e-159	513.0	COG0527@1|root,COG0527@2|Bacteria,46SIS@74201|Verrucomicrobia,2ITJM@203494|Verrucomicrobiae	203494|Verrucomicrobiae	E	Amino acid kinase family	-	-	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT,ACT_7
HKD3_k127_109424_7	497964.CfE428DRAFT_1700	3.43e-144	465.0	COG0498@1|root,COG0498@2|Bacteria,46USE@74201|Verrucomicrobia	74201|Verrucomicrobia	E	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine	-	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HKD3_k127_109424_1	583355.Caka_2205	5.133e-288	918.0	COG0022@1|root,COG0508@1|root,COG1071@1|root,COG0022@2|Bacteria,COG0508@2|Bacteria,COG1071@2|Bacteria,46TPF@74201|Verrucomicrobia,3K7MS@414999|Opitutae	414999|Opitutae	C	Transketolase, pyrimidine binding domain	-	-	1.2.4.4	ko:K11381	ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130	M00036	R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00027,RC00627,RC02743,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh,Transket_pyr,Transketolase_C
HKD3_k127_109424_14	497964.CfE428DRAFT_2007	1.756e-68	242.0	COG0558@1|root,COG0558@2|Bacteria,46T66@74201|Verrucomicrobia	74201|Verrucomicrobia	I	CDP-alcohol phosphatidyltransferase	-	-	2.7.8.5	ko:K00995	ko00564,ko01100,map00564,map01100	-	R01801	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
HKD3_k127_109424_9	1396141.BATP01000003_gene4878	8.658e-124	412.0	COG1160@1|root,COG1160@2|Bacteria,46SJY@74201|Verrucomicrobia,2ITU6@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	KH-domain-like of EngA bacterial GTPase enzymes, C-terminal	der	-	-	ko:K03977	-	-	-	-	ko00000,ko03009	-	-	-	KH_dom-like,MMR_HSR1
HKD3_k127_109424_5	497964.CfE428DRAFT_3456	8.689e-164	520.0	COG0714@1|root,COG0714@2|Bacteria,46S9V@74201|Verrucomicrobia	74201|Verrucomicrobia	S	ATPase family associated with various cellular activities (AAA)	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
HKD3_k127_109424_10	497964.CfE428DRAFT_3457	1.692e-123	403.0	COG1721@1|root,COG1721@2|Bacteria,46TNC@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
HKD3_k127_109424_18	497964.CfE428DRAFT_3458	1.937e-38	149.0	2DR3K@1|root,33A0U@2|Bacteria,46WR8@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4381
HKD3_k127_109424_11	497964.CfE428DRAFT_3459	2.41e-117	387.0	COG2304@1|root,COG2304@2|Bacteria,46TTR@74201|Verrucomicrobia	74201|Verrucomicrobia	S	von Willebrand factor type A domain	-	-	-	-	-	-	-	-	-	-	-	-	BatA,VWA
HKD3_k127_109424_8	497964.CfE428DRAFT_3460	6.121e-144	483.0	COG0457@1|root,COG2304@1|root,COG0457@2|Bacteria,COG2304@2|Bacteria,46SP8@74201|Verrucomicrobia	74201|Verrucomicrobia	J	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	VWA_2
HKD3_k127_109424_12	497964.CfE428DRAFT_3461	7.319e-94	331.0	COG0457@1|root,COG0457@2|Bacteria,46SZM@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Oxygen tolerance	-	-	-	-	-	-	-	-	-	-	-	-	BatD
HKD3_k127_109424_17	497964.CfE428DRAFT_3462	3.663e-39	156.0	COG0457@1|root,COG0457@2|Bacteria,46W7V@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_109424_4	649638.Trad_2886	1.327e-168	541.0	COG1057@1|root,COG1057@2|Bacteria	2|Bacteria	H	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)	nadD	GO:0000309,GO:0003674,GO:0003824,GO:0004515,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	2.7.7.18,3.6.1.55	ko:K00969,ko:K03574	ko00760,ko01100,map00760,map01100	M00115	R00137,R03005	RC00002	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	CTP_transf_like
HKD3_k127_109424_16	1089548.KI783301_gene2344	1.25e-49	187.0	COG0388@1|root,COG0388@2|Bacteria,1TQDK@1239|Firmicutes,4HC44@91061|Bacilli	91061|Bacilli	S	Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase	mtnU	-	3.5.1.3	ko:K13566	ko00250,map00250	-	R00269,R00348	RC00010	ko00000,ko00001,ko01000	-	-	-	CN_hydrolase
HKD3_k127_109424_2	452637.Oter_1399	1.296e-261	822.0	COG1966@1|root,COG1966@2|Bacteria,46V26@74201|Verrucomicrobia,3K9J7@414999|Opitutae	414999|Opitutae	T	PFAM carbon starvation protein CstA	-	-	-	ko:K06200	-	-	-	-	ko00000	-	-	-	CstA,CstA_5TM
HKD3_k127_109424_19	1304275.C41B8_07522	2.939e-23	108.0	2EFWC@1|root,339NM@2|Bacteria,1NG7T@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_109424_0	1396141.BATP01000007_gene5676	5.375e-317	994.0	COG0525@1|root,COG0525@2|Bacteria,46SGP@74201|Verrucomicrobia,2IU1F@203494|Verrucomicrobiae	203494|Verrucomicrobiae	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
HKD3_k127_109424_15	261292.Nit79A3_1487	1.444e-51	201.0	2AM5X@1|root,31C0B@2|Bacteria,1PK3H@1224|Proteobacteria,2W8E1@28216|Betaproteobacteria,374C1@32003|Nitrosomonadales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_109424_13	378806.STAUR_6417	2.375e-77	268.0	COG0796@1|root,COG0796@2|Bacteria,1NAI2@1224|Proteobacteria,42P58@68525|delta/epsilon subdivisions,2WKYK@28221|Deltaproteobacteria,2YY1K@29|Myxococcales	28221|Deltaproteobacteria	M	Provides the (R)-glutamate required for cell wall biosynthesis	murI	-	5.1.1.3	ko:K01776	ko00471,ko01100,map00471,map01100	-	R00260	RC00302	ko00000,ko00001,ko01000,ko01011	-	-	iAF987.Gmet_0547	Asp_Glu_race
HKD3_k127_109424_3	349741.Amuc_1774	1.211e-195	619.0	COG0423@1|root,COG0423@2|Bacteria,46TEV@74201|Verrucomicrobia,2ITMG@203494|Verrucomicrobiae	203494|Verrucomicrobiae	J	Anticodon binding domain	-	-	6.1.1.14	ko:K01880	ko00970,map00970	M00359,M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	HGTP_anticodon,tRNA-synt_2b
HKD3_k127_1094625_2	697282.Mettu_2948	5.469e-61	214.0	2EBDF@1|root,335E4@2|Bacteria,1NH7B@1224|Proteobacteria,1SHGY@1236|Gammaproteobacteria,1XFM2@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_1094625_0	1123255.JHYS01000004_gene1011	2.564e-228	712.0	COG0286@1|root,COG0286@2|Bacteria,1MW3A@1224|Proteobacteria,2VIP4@28216|Betaproteobacteria,4ABKU@80864|Comamonadaceae	28216|Betaproteobacteria	V	N-6 DNA Methylase	-	-	2.1.1.72	ko:K03427	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	HsdM_N,N6_Mtase
HKD3_k127_1094625_1	933262.AXAM01000044_gene1408	1.537e-68	248.0	COG3385@1|root,COG3385@2|Bacteria,1MVRM@1224|Proteobacteria,42U5W@68525|delta/epsilon subdivisions,2WQUQ@28221|Deltaproteobacteria,2MKFC@213118|Desulfobacterales	28221|Deltaproteobacteria	L	PFAM transposase IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,Nterm_IS4
HKD3_k127_1094625_3	857087.Metme_1708	1.452e-10	61.0	COG0732@1|root,COG0732@2|Bacteria,1MXVH@1224|Proteobacteria,1RPS2@1236|Gammaproteobacteria,1XE9M@135618|Methylococcales	135618|Methylococcales	L	PFAM Restriction endonuclease, type I, S subunit, EcoBI	-	-	3.1.21.3	ko:K01154	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	Methylase_S
HKD3_k127_1115089_5	478741.JAFS01000002_gene44	2.571e-67	240.0	COG0791@1|root,COG0791@2|Bacteria,46SVG@74201|Verrucomicrobia,37GHP@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	M	NlpC/P60 family	spr	-	-	-	-	-	-	-	-	-	-	-	NLPC_P60
HKD3_k127_1115089_1	497964.CfE428DRAFT_0210	3.364e-188	597.0	COG0624@1|root,COG0624@2|Bacteria,46UH8@74201|Verrucomicrobia	74201|Verrucomicrobia	E	peptidase dimerisation domain protein	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
HKD3_k127_1115089_4	861299.J421_4223	3.757e-107	362.0	COG0531@1|root,COG0531@2|Bacteria,1ZSZK@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Amino acid permease	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
HKD3_k127_1115089_0	497964.CfE428DRAFT_4695	1.349e-288	927.0	COG1196@1|root,COG1196@2|Bacteria,46TT8@74201|Verrucomicrobia	74201|Verrucomicrobia	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
HKD3_k127_1115089_3	497964.CfE428DRAFT_6473	1.658e-127	417.0	COG1071@1|root,COG1071@2|Bacteria,46UAY@74201|Verrucomicrobia	74201|Verrucomicrobia	C	Dehydrogenase E1 component	-	-	1.2.4.1	ko:K00161	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
HKD3_k127_1115089_2	497964.CfE428DRAFT_6472	5.958e-162	514.0	COG0022@1|root,COG0022@2|Bacteria,46UID@74201|Verrucomicrobia	74201|Verrucomicrobia	C	Transketolase, pyrimidine binding domain	-	-	1.2.4.1	ko:K00162	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
HKD3_k127_1127743_2	204669.Acid345_1151	5.624e-124	406.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,3Y3NT@57723|Acidobacteria,2JIBK@204432|Acidobacteriia	204432|Acidobacteriia	EU	Dipeptidyl peptidase IV (DPP IV) N-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	DPPIV_N,PD40,Peptidase_S9
HKD3_k127_1127743_3	1163617.SCD_n00020	1.898e-98	342.0	COG0668@1|root,COG0668@2|Bacteria,1MW7V@1224|Proteobacteria,2VHE7@28216|Betaproteobacteria	28216|Betaproteobacteria	M	mechanosensitive ion channel	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel
HKD3_k127_1127743_1	1267534.KB906756_gene3	1.681e-147	474.0	COG1680@1|root,COG1680@2|Bacteria	2|Bacteria	V	peptidase activity	-	-	3.4.16.4	ko:K01286	-	-	-	-	ko00000,ko01000	-	-	-	Beta-lactamase
HKD3_k127_1127743_5	234621.RER_26670	1.476e-09	61.0	COG1680@1|root,COG1680@2|Bacteria,2GIX5@201174|Actinobacteria,4FUZ3@85025|Nocardiaceae	201174|Actinobacteria	V	COG1680 Beta-lactamase class C and other penicillin binding proteins	-	-	3.4.16.4	ko:K01286	-	-	-	-	ko00000,ko01000	-	-	-	Beta-lactamase
HKD3_k127_1127743_0	1396418.BATQ01000158_gene2454	2.241e-174	551.0	COG0031@1|root,COG0031@2|Bacteria,46XBI@74201|Verrucomicrobia,2IVBD@203494|Verrucomicrobiae	203494|Verrucomicrobiae	E	Pyridoxal-phosphate dependent enzyme	-	-	-	-	-	-	-	-	-	-	-	-	PALP
HKD3_k127_1127743_7	1392489.JPOL01000002_gene426	7.574e-05	48.0	COG2259@1|root,COG2259@2|Bacteria,4NSBJ@976|Bacteroidetes,1I2WV@117743|Flavobacteriia	976|Bacteroidetes	S	DoxX family	-	-	-	ko:K15977	-	-	-	-	ko00000	-	-	-	DoxX
HKD3_k127_1127743_6	478741.JAFS01000001_gene2213	3.399e-08	60.0	COG2259@1|root,COG2259@2|Bacteria	2|Bacteria	S	methylamine metabolic process	ndh	-	1.6.99.3,1.8.5.2	ko:K03885,ko:K16937	ko00190,ko00920,ko01120,map00190,map00920,map01120	-	R07177	-	ko00000,ko00001,ko01000	3.D.4.9	-	-	DoxD,DoxX,Pyr_redox_2
HKD3_k127_1127743_4	886293.Sinac_4113	6.798e-20	91.0	COG4977@1|root,COG4977@2|Bacteria,2IXH9@203682|Planctomycetes	203682|Planctomycetes	K	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain	-	-	-	ko:K17736	-	-	-	-	ko00000,ko03000	-	-	-	DJ-1_PfpI,HTH_18
HKD3_k127_1192822_1	497964.CfE428DRAFT_5501	9.716e-69	236.0	COG0008@1|root,COG0008@2|Bacteria,46S4X@74201|Verrucomicrobia	74201|Verrucomicrobia	J	glutaminyl-tRNA synthetase	glnS	-	6.1.1.18	ko:K01886	ko00970,ko01100,map00970,map01100	M00359,M00360	R03652	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1c,tRNA-synt_1c_C
HKD3_k127_1192822_0	497964.CfE428DRAFT_1797	1.301e-168	540.0	COG0008@1|root,COG0008@2|Bacteria,46SJ3@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
HKD3_k127_121535_3	1121430.JMLG01000010_gene185	5.29e-59	213.0	COG0547@1|root,COG0547@2|Bacteria,1TP8U@1239|Firmicutes,247WY@186801|Clostridia,2600U@186807|Peptococcaceae	186801|Clostridia	F	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)	trpD	-	2.4.2.18,4.1.3.27	ko:K00766,ko:K13497	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R00985,R00986,R01073	RC00010,RC00440,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3
HKD3_k127_121535_0	1396418.BATQ01000155_gene2459	2.758e-157	513.0	COG0147@1|root,COG0147@2|Bacteria,46S4I@74201|Verrucomicrobia,2ITH7@203494|Verrucomicrobiae	203494|Verrucomicrobiae	EH	Anthranilate synthase component I, N terminal region	-	-	4.1.3.27	ko:K01657	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
HKD3_k127_121535_2	497964.CfE428DRAFT_0598	5.847e-82	276.0	COG0512@1|root,COG0512@2|Bacteria,46SN1@74201|Verrucomicrobia	74201|Verrucomicrobia	EH	PFAM glutamine amidotransferase class-I	-	-	4.1.3.27	ko:K01658	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
HKD3_k127_121535_1	204669.Acid345_1883	1.513e-89	299.0	COG2876@1|root,COG2876@2|Bacteria,3Y32G@57723|Acidobacteria,2JIXH@204432|Acidobacteriia	204432|Acidobacteriia	E	NeuB family	-	-	2.5.1.54	ko:K03856	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_1
HKD3_k127_1217944_18	448385.sce7110	3.253e-39	149.0	COG0454@1|root,COG0456@2|Bacteria,1PWDA@1224|Proteobacteria,43586@68525|delta/epsilon subdivisions,2WZJ8@28221|Deltaproteobacteria,2Z296@29|Myxococcales	28221|Deltaproteobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HKD3_k127_1217944_5	485913.Krac_1073	5.99e-112	366.0	COG4221@1|root,COG4221@2|Bacteria,2G6TQ@200795|Chloroflexi	200795|Chloroflexi	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HKD3_k127_1217944_1	316056.RPC_4894	2.189e-166	527.0	COG0667@1|root,COG0667@2|Bacteria,1MVEH@1224|Proteobacteria,2TRHS@28211|Alphaproteobacteria,3JVP4@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Aldo keto reductase	-	-	1.1.1.65	ko:K05275	ko00750,ko01100,ko01120,map00750,map01100,map01120	-	R01708	RC00116	ko00000,ko00001,ko01000	-	-	-	Aldo_ket_red
HKD3_k127_1217944_17	234267.Acid_4188	2.648e-41	161.0	COG1266@1|root,COG1266@2|Bacteria,3Y5CJ@57723|Acidobacteria	57723|Acidobacteria	S	PFAM Abortive infection protein	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
HKD3_k127_1217944_11	114615.BRADO6457	7.323e-69	242.0	COG0432@1|root,COG0432@2|Bacteria,1RA5G@1224|Proteobacteria,2U5FG@28211|Alphaproteobacteria,3JY4S@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Uncharacterised protein family UPF0047	-	-	-	-	-	-	-	-	-	-	-	-	UPF0047
HKD3_k127_1217944_7	1047013.AQSP01000089_gene1181	1.281e-107	375.0	COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria	2|Bacteria	S	cAMP biosynthetic process	cyaJ	-	4.6.1.1	ko:K01768,ko:K02483	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000,ko02022	-	-	-	Guanylate_cyc,HTH_18,TPR_16,TPR_19,TPR_2,TPR_8
HKD3_k127_1217944_4	1183438.GKIL_4354	9.285e-135	462.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HKD3_k127_1217944_16	1267535.KB906767_gene1916	6.972e-45	165.0	COG1695@1|root,COG1695@2|Bacteria,3Y5C5@57723|Acidobacteria,2JNCX@204432|Acidobacteriia	204432|Acidobacteriia	K	Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	PadR
HKD3_k127_1217944_9	196490.AUEZ01000055_gene235	5.371e-78	263.0	2AUXR@1|root,2ZBPW@2|Bacteria,1RAID@1224|Proteobacteria,2U6KV@28211|Alphaproteobacteria,3JYM4@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_1217944_12	530564.Psta_0156	3.435e-68	249.0	2F56J@1|root,33XTA@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_1217944_10	278963.ATWD01000001_gene3838	6.989e-70	237.0	COG1917@1|root,COG1917@2|Bacteria,3Y4HX@57723|Acidobacteria,2JJ92@204432|Acidobacteriia	204432|Acidobacteriia	S	PFAM Cupin 2, conserved barrel	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HKD3_k127_1217944_24	1382306.JNIM01000001_gene2128	4.155e-07	54.0	2BHPS@1|root,32BT1@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_1217944_0	204669.Acid345_0840	6.676e-254	787.0	COG1249@1|root,COG1249@2|Bacteria,3Y3KM@57723|Acidobacteria,2JICF@204432|Acidobacteriia	204432|Acidobacteriia	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,Pyr_redox_dim
HKD3_k127_1217944_8	404589.Anae109_1057	2.558e-107	351.0	COG0346@1|root,COG0346@2|Bacteria,1MV4D@1224|Proteobacteria	1224|Proteobacteria	E	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HKD3_k127_1217944_19	861299.J421_6000	1.374e-23	107.0	COG0789@1|root,COG0789@2|Bacteria,1ZVAN@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	MerR, DNA binding	-	-	-	ko:K13639	-	-	-	-	ko00000,ko03000	-	-	-	-
HKD3_k127_1217944_25	1081640.AGFU01000067_gene3611	5.756e-06	55.0	COG0662@1|root,COG0662@2|Bacteria,1NVCR@1224|Proteobacteria,2URU1@28211|Alphaproteobacteria,2K599@204457|Sphingomonadales	204457|Sphingomonadales	G	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_1,Cupin_2
HKD3_k127_1217944_22	1006000.GKAS_00437	4.399e-18	89.0	COG1226@1|root,COG4651@1|root,COG1226@2|Bacteria,COG4651@2|Bacteria,1MV34@1224|Proteobacteria,1RMM7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family	ybaL	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03455	-	-	-	-	ko00000	2.A.37	-	-	Na_H_Exchanger,TrkA_N
HKD3_k127_1217944_2	266835.14021838	1.741e-151	482.0	COG2267@1|root,COG2267@2|Bacteria,1MUG8@1224|Proteobacteria,2TRUA@28211|Alphaproteobacteria,43JM2@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	I	Serine aminopeptidase, S33	-	-	1.11.1.10	ko:K00433	-	-	-	-	ko00000,ko01000	-	-	-	Abhydrolase_1
HKD3_k127_1217944_6	485913.Krac_5038	1.586e-110	371.0	COG0702@1|root,COG0702@2|Bacteria	2|Bacteria	GM	epimerase	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_10
HKD3_k127_1217944_15	1218084.BBJK01000013_gene1334	3.464e-54	195.0	COG1917@1|root,COG1917@2|Bacteria,1RGZB@1224|Proteobacteria,2VSYK@28216|Betaproteobacteria,1K7T6@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HKD3_k127_1217944_23	1380394.JADL01000002_gene1162	1.577e-17	88.0	COG0782@1|root,COG0782@2|Bacteria,1RHU5@1224|Proteobacteria,2U95I@28211|Alphaproteobacteria,2JX3W@204441|Rhodospirillales	204441|Rhodospirillales	K	Transcription elongation factor, GreA/GreB, C-term	-	-	-	-	-	-	-	-	-	-	-	-	GreA_GreB
HKD3_k127_1217944_14	945713.IALB_2676	3.76e-58	211.0	COG4947@1|root,COG4947@2|Bacteria	2|Bacteria	P	esterase	XK27_05675	-	-	-	-	-	-	-	-	-	-	-	Esterase
HKD3_k127_1217944_13	1380394.JADL01000002_gene1525	3.063e-60	215.0	COG3791@1|root,COG3791@2|Bacteria,1RFBP@1224|Proteobacteria,2U7YA@28211|Alphaproteobacteria,2JUEE@204441|Rhodospirillales	204441|Rhodospirillales	S	Glutathione-dependent formaldehyde-activating enzyme	-	-	-	-	-	-	-	-	-	-	-	-	GFA
HKD3_k127_1217944_3	452637.Oter_2865	1.399e-135	438.0	COG1398@1|root,COG1398@2|Bacteria,46TJ8@74201|Verrucomicrobia,3K9F4@414999|Opitutae	414999|Opitutae	I	PFAM fatty acid desaturase	-	-	1.14.19.1	ko:K00507	ko01040,ko01212,ko03320,ko04152,ko04212,map01040,map01212,map03320,map04152,map04212	-	R02222	RC00917	ko00000,ko00001,ko01000,ko01004	-	-	-	FA_desaturase
HKD3_k127_1217944_20	1156937.MFUM_290017	1.67e-23	102.0	COG0361@1|root,COG0361@2|Bacteria,46T5J@74201|Verrucomicrobia,37H0F@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	J	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex	infA	-	-	ko:K02518	-	-	-	-	ko00000,ko03012	-	-	-	eIF-1a
HKD3_k127_1217944_21	497964.CfE428DRAFT_4858	2.505e-20	92.0	COG0724@1|root,COG0724@2|Bacteria,46VMU@74201|Verrucomicrobia	74201|Verrucomicrobia	S	PFAM RNP-1 like RNA-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	RRM_1
HKD3_k127_1230821_0	483219.LILAB_25795	2.526e-116	391.0	COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,42MAH@68525|delta/epsilon subdivisions,2WJT7@28221|Deltaproteobacteria,2YVB7@29|Myxococcales	28221|Deltaproteobacteria	J	Amidase	-	-	3.5.1.4,6.3.5.6,6.3.5.7	ko:K01426,ko:K02433	ko00330,ko00360,ko00380,ko00627,ko00643,ko00970,ko01100,ko01120,map00330,map00360,map00380,map00627,map00643,map00970,map01100,map01120	-	R02540,R03096,R03180,R03905,R03909,R04212,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
HKD3_k127_1230821_1	886293.Sinac_4404	5.884e-38	157.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_1
HKD3_k127_1284349_1	1173027.Mic7113_3145	2.35e-157	504.0	COG0626@1|root,COG0626@2|Bacteria,1G43Q@1117|Cyanobacteria,1HHPF@1150|Oscillatoriales	1117|Cyanobacteria	E	PFAM Cys Met metabolism PLP-dependent enzyme	metB	-	2.5.1.48,4.4.1.1	ko:K01739,ko:K01758	ko00260,ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00260,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017,M00338	R00782,R00999,R01001,R01288,R02408,R02508,R03217,R03260,R04770,R04930,R04944,R04945,R04946,R09366	RC00020,RC00056,RC00069,RC00348,RC00382,RC00420,RC00710,RC01209,RC01210,RC01245,RC02303,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Cys_Met_Meta_PP
HKD3_k127_1284349_0	497964.CfE428DRAFT_4028	6.509e-165	534.0	COG0728@1|root,COG0728@2|Bacteria,46SH1@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane	murJ	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
HKD3_k127_1284349_2	452637.Oter_1975	2.582e-26	114.0	COG1943@1|root,COG1943@2|Bacteria,46VNW@74201|Verrucomicrobia,3K8JJ@414999|Opitutae	414999|Opitutae	L	Transposase IS200 like	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
HKD3_k127_1313200_13	794903.OPIT5_02660	6.275e-41	156.0	COG0652@1|root,COG0652@2|Bacteria,46VEN@74201|Verrucomicrobia,3K93U@414999|Opitutae	414999|Opitutae	O	Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD	-	-	-	-	-	-	-	-	-	-	-	-	Pro_isomerase
HKD3_k127_1313200_0	1403819.BATR01000008_gene271	0.0	1499.0	COG0458@1|root,COG0458@2|Bacteria,46SBT@74201|Verrucomicrobia,2IU2N@203494|Verrucomicrobiae	203494|Verrucomicrobiae	EF	Carbamoyl-phosphate synthetase large chain, oligomerisation domain	-	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
HKD3_k127_1313200_9	497964.CfE428DRAFT_1077	8.936e-61	213.0	COG2166@1|root,COG2166@2|Bacteria,46SRH@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Fe-S metabolism associated domain	sufE	-	-	ko:K02426	-	-	-	-	ko00000	-	-	-	SufE
HKD3_k127_1313200_4	1396418.BATQ01000133_gene4037	4.118e-152	488.0	COG0039@1|root,COG0039@2|Bacteria,46SC4@74201|Verrucomicrobia,2ITGY@203494|Verrucomicrobiae	203494|Verrucomicrobiae	C	Catalyzes the reversible oxidation of malate to oxaloacetate	-	-	1.1.1.37	ko:K00024	ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740	R00342,R07136	RC00031	ko00000,ko00001,ko00002,ko01000	-	-	-	Ldh_1_C,Ldh_1_N
HKD3_k127_1313200_19	797114.C475_02071	5.102e-05	52.0	COG3794@1|root,arCOG02920@2157|Archaea,2XZQ0@28890|Euryarchaeota,23X32@183963|Halobacteria	183963|Halobacteria	C	Copper binding proteins, plastocyanin/azurin family	hcp1	-	-	-	-	-	-	-	-	-	-	-	Copper-bind
HKD3_k127_1313200_18	2045.KR76_07020	8.799e-12	69.0	COG0039@1|root,COG0039@2|Bacteria,2GJHS@201174|Actinobacteria,4DN1I@85009|Propionibacteriales	201174|Actinobacteria	C	Catalyzes the reversible oxidation of malate to oxaloacetate	mdh	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006107,GO:0006108,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009060,GO:0009117,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016614,GO:0016615,GO:0016616,GO:0016999,GO:0017144,GO:0019362,GO:0019637,GO:0019674,GO:0019752,GO:0030060,GO:0030312,GO:0034641,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046483,GO:0046496,GO:0051186,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072350,GO:0072524,GO:1901360,GO:1901564	1.1.1.37	ko:K00024	ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740	R00342,R07136	RC00031	ko00000,ko00001,ko00002,ko01000	-	-	-	Ldh_1_C,Ldh_1_N
HKD3_k127_1313200_15	1123508.JH636450_gene7219	1.078e-31	135.0	COG1404@1|root,COG2911@1|root,COG2931@1|root,COG3210@1|root,COG3391@1|root,COG4935@1|root,COG1404@2|Bacteria,COG2911@2|Bacteria,COG2931@2|Bacteria,COG3210@2|Bacteria,COG3391@2|Bacteria,COG4935@2|Bacteria,2IZWN@203682|Planctomycetes	203682|Planctomycetes	Q	HemY domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_1313200_10	1449976.KALB_79	9.305e-57	207.0	COG2227@1|root,COG2227@2|Bacteria	2|Bacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	-	-	2.1.1.222,2.1.1.64	ko:K00568,ko:K15257	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04988,R05614,R08769,R08781	RC00003,RC00392,RC01895	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	Methyltransf_23,Methyltransf_31,Methyltransf_9
HKD3_k127_1313200_8	351348.Maqu_2638	1.274e-67	238.0	COG0500@1|root,COG0500@2|Bacteria,1QT89@1224|Proteobacteria,1SVTS@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_1313200_3	556261.HMPREF0240_03243	1.348e-155	506.0	COG3119@1|root,COG3119@2|Bacteria,1TSUU@1239|Firmicutes,25CDH@186801|Clostridia,36WTZ@31979|Clostridiaceae	186801|Clostridia	P	Type I phosphodiesterase / nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
HKD3_k127_1313200_5	497964.CfE428DRAFT_2622	6.387e-133	430.0	COG0152@1|root,COG0152@2|Bacteria,46SIP@74201|Verrucomicrobia	74201|Verrucomicrobia	F	SAICAR synthetase	purC	-	6.3.2.6	ko:K01923	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04591	RC00064,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	SAICAR_synt
HKD3_k127_1313200_6	1396418.BATQ01000127_gene2563	3.399e-129	423.0	COG1092@1|root,COG1092@2|Bacteria,46SJ5@74201|Verrucomicrobia,2ITMI@203494|Verrucomicrobiae	203494|Verrucomicrobiae	J	S-adenosylmethionine-dependent methyltransferase	-	-	2.1.1.191	ko:K06969	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_SAM
HKD3_k127_1313200_12	497964.CfE428DRAFT_3409	3.052e-42	162.0	2FHDV@1|root,34981@2|Bacteria,46W9B@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_1313200_14	497964.CfE428DRAFT_3411	6.973e-33	130.0	COG0721@1|root,COG0721@2|Bacteria,46TA2@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatC	-	6.3.5.6,6.3.5.7	ko:K02435	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Glu-tRNAGln
HKD3_k127_1313200_2	497964.CfE428DRAFT_3412	2.849e-233	731.0	COG0154@1|root,COG0154@2|Bacteria,46SCM@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
HKD3_k127_1313200_1	497964.CfE428DRAFT_2396	1.123e-302	940.0	COG0441@1|root,COG0441@2|Bacteria,46S5A@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	-	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA_SAD
HKD3_k127_1313200_16	580332.Slit_1242	2.153e-30	123.0	COG0664@1|root,COG0664@2|Bacteria,1N6WV@1224|Proteobacteria,2VWSV@28216|Betaproteobacteria,44WIM@713636|Nitrosomonadales	28216|Betaproteobacteria	K	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
HKD3_k127_1313200_7	1454004.AW11_00497	1.465e-85	290.0	COG2518@1|root,COG2518@2|Bacteria,1MXQC@1224|Proteobacteria,2VKBQ@28216|Betaproteobacteria	28216|Betaproteobacteria	J	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	-	-	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
HKD3_k127_1313200_17	118161.KB235922_gene5226	1.98e-17	89.0	2A4TS@1|root,30TF8@2|Bacteria,1GE0Y@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_1313200_11	1173263.Syn7502_00101	3.252e-55	211.0	COG1807@1|root,COG1807@2|Bacteria,1GCHJ@1117|Cyanobacteria,1GZTK@1129|Synechococcus	1117|Cyanobacteria	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HKD3_k127_1314665_2	240015.ACP_3026	1.095e-27	114.0	COG2986@1|root,COG2986@2|Bacteria,3Y3YW@57723|Acidobacteria,2JIK6@204432|Acidobacteriia	204432|Acidobacteriia	E	Aromatic amino acid lyase	hutH	-	4.3.1.3	ko:K01745	ko00340,ko01100,map00340,map01100	M00045	R01168	RC00361	ko00000,ko00001,ko00002,ko01000	-	-	-	Lyase_aromatic
HKD3_k127_1314665_1	240016.ABIZ01000001_gene5611	5.375e-39	150.0	COG1376@1|root,COG1376@2|Bacteria,46VRV@74201|Verrucomicrobia,2IUQ8@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	L,D-transpeptidase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	YkuD
HKD3_k127_1314665_0	497964.CfE428DRAFT_5395	7.006e-134	435.0	COG0136@1|root,COG0136@2|Bacteria,46S74@74201|Verrucomicrobia	74201|Verrucomicrobia	E	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate	asd	-	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
HKD3_k127_1343344_10	1392489.JPOL01000003_gene105	2.824e-15	77.0	COG1840@1|root,COG1840@2|Bacteria,4NJ1Z@976|Bacteroidetes,1HXNT@117743|Flavobacteriia	976|Bacteroidetes	P	Bacterial extracellular solute-binding protein	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_11,SBP_bac_6,SBP_bac_8
HKD3_k127_1343344_4	1037409.BJ6T_17370	2.334e-79	272.0	COG3848@1|root,COG3848@2|Bacteria,1R7DS@1224|Proteobacteria,2U3SK@28211|Alphaproteobacteria,3JSC8@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Pyruvate phosphate dikinase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_1343344_1	269482.Bcep1808_6110	2.672e-103	344.0	COG1388@1|root,COG1388@2|Bacteria,1MY1S@1224|Proteobacteria,2VZIM@28216|Betaproteobacteria,1K4M4@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Domain of Unknown Function (DUF1259)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1529
HKD3_k127_1343344_7	1396141.BATP01000027_gene1050	2.25e-63	223.0	COG1280@1|root,COG1280@2|Bacteria,46W68@74201|Verrucomicrobia,2IVKQ@203494|Verrucomicrobiae	203494|Verrucomicrobiae	E	LysE type translocator	-	-	-	-	-	-	-	-	-	-	-	-	LysE
HKD3_k127_1343344_9	1042877.GQS_00390	7.601e-37	145.0	COG4275@1|root,arCOG10427@2157|Archaea,2XXPQ@28890|Euryarchaeota,244YW@183968|Thermococci	183968|Thermococci	S	Chromate resistance exported protein	-	-	-	-	-	-	-	-	-	-	-	-	Chrome_Resist
HKD3_k127_1343344_3	861299.J421_1374	3.588e-90	308.0	COG2423@1|root,COG2423@2|Bacteria	2|Bacteria	E	ornithine cyclodeaminase activity	ocd2	-	1.4.1.1,1.5.1.25,4.3.1.12	ko:K01750,ko:K18258,ko:K19244	ko00250,ko00330,ko00430,ko01100,ko01110,ko01130,ko01230,map00250,map00330,map00430,map01100,map01110,map01130,map01230	-	R00396,R00671	RC00008,RC00354	ko00000,ko00001,ko01000,ko04147	-	-	-	OCD_Mu_crystall
HKD3_k127_1343344_6	176946.XP_007422076.1	6.966e-71	246.0	COG3340@1|root,2QR7X@2759|Eukaryota,39DGA@33154|Opisthokonta,3BC18@33208|Metazoa,3CWYN@33213|Bilateria,484TW@7711|Chordata,499CC@7742|Vertebrata	33208|Metazoa	E	Alpha-aspartyl dipeptidase-like	-	GO:0003674,GO:0003824,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0016787,GO:0019538,GO:0043170,GO:0044238,GO:0071704,GO:0140096,GO:1901564	3.4.13.21	ko:K05995	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S51
HKD3_k127_1343344_2	497964.CfE428DRAFT_6528	2.714e-93	315.0	COG4275@1|root,COG4275@2|Bacteria	2|Bacteria	S	Chromate resistance exported protein	chrB	-	-	-	-	-	-	-	-	-	-	-	Chrome_Resist
HKD3_k127_1343344_5	1123073.KB899242_gene950	4.981e-74	265.0	COG2059@1|root,COG2059@2|Bacteria,1MUBW@1224|Proteobacteria,1RPNP@1236|Gammaproteobacteria,1X53Q@135614|Xanthomonadales	135614|Xanthomonadales	P	Chromate transporter	-	-	-	ko:K07240	-	-	-	-	ko00000,ko02000	2.A.51.1	-	-	Chromate_transp
HKD3_k127_1343344_0	1380355.JNIJ01000040_gene5198	0.0	1322.0	COG0841@1|root,COG0841@2|Bacteria,1R93M@1224|Proteobacteria,2UP7I@28211|Alphaproteobacteria,3K354@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	V	AcrB/AcrD/AcrF family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
HKD3_k127_1343344_8	330214.NIDE1686	5.722e-59	220.0	COG0845@1|root,COG0845@2|Bacteria,3J13H@40117|Nitrospirae	40117|Nitrospirae	M	HlyD family secretion protein	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_D23
HKD3_k127_1343344_11	497965.Cyan7822_2189	6.252e-14	84.0	COG1538@1|root,COG5373@1|root,COG1538@2|Bacteria,COG5373@2|Bacteria,1G0B8@1117|Cyanobacteria,3KGYW@43988|Cyanothece	1117|Cyanobacteria	MU	outer membrane efflux protein	-	-	-	ko:K03287	-	-	-	-	ko00000	1.B.17	-	-	OEP
HKD3_k127_1345055_25	1415779.JOMH01000001_gene124	1.35e-06	61.0	COG1807@1|root,COG1807@2|Bacteria	2|Bacteria	M	4-amino-4-deoxy-L-arabinose transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_22,PMT,PMT_2
HKD3_k127_1345055_17	1121448.DGI_0529	8.187e-43	179.0	COG3391@1|root,COG3391@2|Bacteria,1NT97@1224|Proteobacteria,42RMY@68525|delta/epsilon subdivisions,2WNJD@28221|Deltaproteobacteria,2MF83@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	NHL repeat	-	-	-	-	-	-	-	-	-	-	-	-	NHL
HKD3_k127_1345055_22	1121335.Clst_1370	2.563e-22	113.0	COG5427@1|root,COG5427@2|Bacteria,1UXXM@1239|Firmicutes,24EF9@186801|Clostridia,3WHFN@541000|Ruminococcaceae	186801|Clostridia	M	chaperone-mediated protein folding	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_1345055_16	1121448.DGI_0529	2.353e-44	186.0	COG3391@1|root,COG3391@2|Bacteria,1NT97@1224|Proteobacteria,42RMY@68525|delta/epsilon subdivisions,2WNJD@28221|Deltaproteobacteria,2MF83@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	NHL repeat	-	-	-	-	-	-	-	-	-	-	-	-	NHL
HKD3_k127_1345055_18	521011.Mpal_1474	9.978e-42	178.0	COG0614@1|root,arCOG03561@1|root,arCOG03561@2157|Archaea,arCOG03611@2157|Archaea,2Y1Q9@28890|Euryarchaeota,2N9M9@224756|Methanomicrobia	224756|Methanomicrobia	P	PFAM NHL repeat containing protein	-	-	-	-	-	-	-	-	-	-	-	-	FlgD_ig,NHL
HKD3_k127_1345055_15	1304874.JAFY01000002_gene694	1.638e-52	213.0	COG5427@1|root,COG5427@2|Bacteria,3TC17@508458|Synergistetes	508458|Synergistetes	M	chaperone-mediated protein folding	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_1345055_23	1242864.D187_010175	2.746e-11	76.0	COG1807@1|root,COG1807@2|Bacteria,1Q2FK@1224|Proteobacteria,4381I@68525|delta/epsilon subdivisions,2X3BM@28221|Deltaproteobacteria,2YUUG@29|Myxococcales	28221|Deltaproteobacteria	M	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_1345055_6	497964.CfE428DRAFT_4962	1.383e-94	316.0	COG0176@1|root,COG0176@2|Bacteria,46TNS@74201|Verrucomicrobia	74201|Verrucomicrobia	H	PFAM Transaldolase	-	-	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
HKD3_k127_1345055_13	497964.CfE428DRAFT_2552	5.429e-57	209.0	COG0241@1|root,COG0241@2|Bacteria,46T3Q@74201|Verrucomicrobia	74201|Verrucomicrobia	E	hydrolase, HAD-superfamily, subfamily IIIA	-	-	3.1.3.82,3.1.3.83	ko:K03273	ko00540,ko01100,map00540,map01100	M00064	R05647,R09771	RC00017	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	HAD_2,Hydrolase_like
HKD3_k127_1345055_8	497964.CfE428DRAFT_2551	1.337e-91	304.0	COG0279@1|root,COG0279@2|Bacteria,46TRG@74201|Verrucomicrobia	74201|Verrucomicrobia	G	SIS domain	-	-	5.3.1.28	ko:K03271	ko00540,ko01100,map00540,map01100	M00064	R05645,R09768,R09769	RC00434	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	SIS_2
HKD3_k127_1345055_9	497964.CfE428DRAFT_2550	1.358e-90	304.0	COG1208@1|root,COG1208@2|Bacteria,46UUZ@74201|Verrucomicrobia	74201|Verrucomicrobia	JM	Nucleotidyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transferase
HKD3_k127_1345055_2	497964.CfE428DRAFT_2549	3.497e-147	472.0	COG2605@1|root,COG2605@2|Bacteria,46UPC@74201|Verrucomicrobia	74201|Verrucomicrobia	H	GHMP kinase domain protein	-	-	2.7.1.168	ko:K07031	ko00540,map00540	-	R09770	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
HKD3_k127_1345055_20	215803.DB30_5801	5.323e-37	156.0	2EJZM@1|root,33DQ6@2|Bacteria,1N7GI@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_1345055_0	497964.CfE428DRAFT_2547	8.208e-180	571.0	COG0463@1|root,COG0463@2|Bacteria,46SXD@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HKD3_k127_1345055_19	1403819.BATR01000022_gene762	2.719e-40	153.0	COG0838@1|root,COG0838@2|Bacteria,46T33@74201|Verrucomicrobia,2IUK0@203494|Verrucomicrobiae	203494|Verrucomicrobiae	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoA	-	1.6.5.3	ko:K00330	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q4
HKD3_k127_1345055_4	497964.CfE428DRAFT_2617	3.917e-120	399.0	COG4974@1|root,COG4974@2|Bacteria,46SSD@74201|Verrucomicrobia	74201|Verrucomicrobia	L	integrase domain protein SAM domain protein	-	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
HKD3_k127_1345055_7	497964.CfE428DRAFT_3494	1.639e-92	310.0	COG3880@1|root,COG3880@2|Bacteria	2|Bacteria	E	PFAM UvrB UvrC protein	omcN	-	-	ko:K08999	-	-	-	-	ko00000	-	-	-	DNase-RNase,GSu_C4xC__C2xCH,Paired_CXXCH_1,UVR
HKD3_k127_1345055_3	481448.Minf_1359	1.619e-130	426.0	COG1494@1|root,COG1494@2|Bacteria,46THC@74201|Verrucomicrobia,37H8X@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	G	Bacterial fructose-1,6-bisphosphatase, glpX-encoded	glpX	-	3.1.3.11	ko:K02446	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200	M00003,M00165,M00167	R00762,R04780	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FBPase_glpX
HKD3_k127_1345055_1	240016.ABIZ01000001_gene4745	4.112e-153	518.0	COG2843@1|root,COG2843@2|Bacteria,46W53@74201|Verrucomicrobia,2IV2F@203494|Verrucomicrobiae	203494|Verrucomicrobiae	M	Bacterial capsule synthesis protein PGA_cap	-	-	-	-	-	-	-	-	-	-	-	-	PGA_cap
HKD3_k127_1345055_14	1396418.BATQ01000044_gene6460	8.568e-55	210.0	COG2304@1|root,COG2304@2|Bacteria,46Z4G@74201|Verrucomicrobia,2IVSP@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Nicotine adenine dinucleotide glycohydrolase (NADase)	-	-	-	-	-	-	-	-	-	-	-	-	NADase_NGA
HKD3_k127_1345055_12	497964.CfE428DRAFT_4864	1.933e-58	211.0	COG1595@1|root,COG1595@2|Bacteria,46VE8@74201|Verrucomicrobia	74201|Verrucomicrobia	K	DNA-templated transcription, initiation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_1345055_5	1379698.RBG1_1C00001G0518	9.439e-97	351.0	COG0515@1|root,COG0515@2|Bacteria,2NQNE@2323|unclassified Bacteria	2|Bacteria	T	Serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase,TPR_2,TPR_8
HKD3_k127_1345055_24	1472716.KBK24_0135635	1.874e-10	68.0	COG1629@1|root,COG4771@2|Bacteria,1MU9K@1224|Proteobacteria,2VN1V@28216|Betaproteobacteria,1K3PT@119060|Burkholderiaceae	28216|Betaproteobacteria	P	TonB dependent receptor	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
HKD3_k127_1358232_1	497964.CfE428DRAFT_0212	8.562e-20	90.0	COG0217@1|root,COG0217@2|Bacteria,46SP3@74201|Verrucomicrobia	74201|Verrucomicrobia	K	transcriptional regulatory protein	-	-	-	-	-	-	-	-	-	-	-	-	Transcrip_reg
HKD3_k127_1358232_0	485913.Krac_10136	2.832e-177	594.0	COG5463@1|root,COG5463@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF1190)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1190
HKD3_k127_1358232_2	1396141.BATP01000039_gene1339	4.302e-11	63.0	COG1217@1|root,COG1217@2|Bacteria,46SHA@74201|Verrucomicrobia,2ITJK@203494|Verrucomicrobiae	203494|Verrucomicrobiae	T	Elongation factor G C-terminus	-	-	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2
HKD3_k127_1371871_1	497964.CfE428DRAFT_2029	4.579e-93	310.0	COG0777@1|root,COG0777@2|Bacteria,46SI0@74201|Verrucomicrobia	74201|Verrucomicrobia	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA	accD	-	2.1.3.15,6.4.1.2	ko:K01963	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
HKD3_k127_1371871_0	497964.CfE428DRAFT_2028	2.72e-122	406.0	COG0285@1|root,COG0285@2|Bacteria,46SKD@74201|Verrucomicrobia	74201|Verrucomicrobia	H	Mur ligase middle domain	folC	-	6.3.2.12,6.3.2.17	ko:K11754	ko00790,ko01100,map00790,map01100	M00126,M00841	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	Mur_ligase_C,Mur_ligase_M
HKD3_k127_1371871_2	497964.CfE428DRAFT_2982	8.836e-16	79.0	COG1595@1|root,COG1595@2|Bacteria,46V3P@74201|Verrucomicrobia	74201|Verrucomicrobia	K	DNA-templated transcription, initiation	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2
HKD3_k127_1390814_6	497964.CfE428DRAFT_3838	1.308e-146	499.0	COG2911@1|root,COG2911@2|Bacteria,46TSK@74201|Verrucomicrobia	74201|Verrucomicrobia	S	TamB, inner membrane protein subunit of TAM complex	-	-	-	-	-	-	-	-	-	-	-	-	TamB
HKD3_k127_1390814_5	497964.CfE428DRAFT_3837	1.136e-153	511.0	COG4775@1|root,COG4775@2|Bacteria,46TFS@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Surface antigen	-	-	-	-	-	-	-	-	-	-	-	-	Bac_surface_Ag,POTRA
HKD3_k127_1390814_7	1382306.JNIM01000001_gene1966	7.389e-137	451.0	COG0076@1|root,COG0076@2|Bacteria,2G7N6@200795|Chloroflexi	200795|Chloroflexi	E	Pyridoxal-dependent decarboxylase conserved domain	-	-	4.1.1.105,4.1.1.28,4.1.2.27	ko:K01593,ko:K01634	ko00350,ko00360,ko00380,ko00600,ko00901,ko00950,ko00965,ko01100,ko01110,ko04071,ko04726,ko04728,ko05030,ko05031,ko05034,map00350,map00360,map00380,map00600,map00901,map00950,map00965,map01100,map01110,map04071,map04726,map04728,map05030,map05031,map05034	M00037,M00042,M00100	R00685,R00699,R00736,R02080,R02464,R02701,R04909,R06516	RC00264,RC00299,RC00721,RC01266	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyridoxal_deC
HKD3_k127_1390814_25	1283284.AZUK01000001_gene2565	1.73e-11	77.0	COG0760@1|root,COG0760@2|Bacteria,1MWV0@1224|Proteobacteria,1RMT5@1236|Gammaproteobacteria,1Y3R6@135624|Aeromonadales	135624|Aeromonadales	O	Peptidylprolyl isomerase	ppiD	-	5.2.1.8	ko:K03770	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase_2,Rotamase_3,SurA_N_3
HKD3_k127_1390814_18	497964.CfE428DRAFT_0050	1.764e-42	163.0	COG3063@1|root,COG3063@2|Bacteria,46T56@74201|Verrucomicrobia	74201|Verrucomicrobia	NU	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	PPR,TPR_11,TPR_2,TPR_8
HKD3_k127_1390814_2	452637.Oter_4614	1.237e-237	753.0	COG3590@1|root,COG3590@2|Bacteria,46UUX@74201|Verrucomicrobia	74201|Verrucomicrobia	O	Peptidase family M13	-	-	-	ko:K07386	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M13,Peptidase_M13_N
HKD3_k127_1390814_21	935863.AWZR01000005_gene2289	6.848e-30	133.0	COG3735@1|root,COG3735@2|Bacteria,1MVCW@1224|Proteobacteria,1RRI8@1236|Gammaproteobacteria,1X5HS@135614|Xanthomonadales	135614|Xanthomonadales	S	protein conserved in bacteria	-	-	-	ko:K09973	-	-	-	-	ko00000	-	-	-	TraB
HKD3_k127_1390814_12	497964.CfE428DRAFT_1387	3.522e-64	235.0	COG0860@1|root,COG0860@2|Bacteria,46SS7@74201|Verrucomicrobia	74201|Verrucomicrobia	M	PFAM cell wall hydrolase autolysin	-	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	Amidase_3
HKD3_k127_1390814_1	583355.Caka_2692	2.033e-307	956.0	COG0422@1|root,COG0422@2|Bacteria,46S5R@74201|Verrucomicrobia,3K77R@414999|Opitutae	414999|Opitutae	H	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction	thiC	-	4.1.99.17	ko:K03147	ko00730,ko01100,map00730,map01100	M00127	R03472	RC03251,RC03252	ko00000,ko00001,ko00002,ko01000	-	-	-	ThiC-associated,ThiC_Rad_SAM
HKD3_k127_1390814_3	204669.Acid345_1623	1.703e-194	614.0	COG0205@1|root,COG0205@2|Bacteria,3Y4A9@57723|Acidobacteria,2JKQ8@204432|Acidobacteriia	204432|Acidobacteriia	G	Phosphofructokinase	-	-	2.7.1.11,2.7.1.90	ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
HKD3_k127_1390814_23	1280952.HJA_05212	2.278e-20	92.0	COG1942@1|root,COG1942@2|Bacteria,1NBW3@1224|Proteobacteria,2UHFK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	4-oxalocrotonate tautomerase	-	-	5.3.2.6	ko:K01821	ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00362,map00621,map00622,map01100,map01120,map01220	M00569	R03966,R05389	RC01040,RC01355	ko00000,ko00001,ko00002,ko01000	-	-	-	Tautomerase
HKD3_k127_1390814_11	1278309.KB907102_gene197	3.387e-65	232.0	COG1733@1|root,COG1733@2|Bacteria,1NEKW@1224|Proteobacteria,1RYP5@1236|Gammaproteobacteria,1XRI6@135619|Oceanospirillales	135619|Oceanospirillales	K	HxlR-like helix-turn-helix	-	-	-	-	-	-	-	-	-	-	-	-	HxlR
HKD3_k127_1390814_10	221288.JH992900_gene387	6.761e-82	278.0	COG2258@1|root,COG2258@2|Bacteria,1G4BR@1117|Cyanobacteria,1JKN0@1189|Stigonemataceae	1117|Cyanobacteria	S	MOSC domain	-	-	-	-	-	-	-	-	-	-	-	-	3-alpha,MOSC
HKD3_k127_1390814_8	330214.NIDE0254	4.01e-121	402.0	COG0006@1|root,COG0006@2|Bacteria	2|Bacteria	E	proline dipeptidase activity	-	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
HKD3_k127_1390814_9	204669.Acid345_4117	7.413e-117	412.0	COG0457@1|root,COG0515@1|root,COG5616@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG5616@2|Bacteria,3Y2HR@57723|Acidobacteria,2JI02@204432|Acidobacteriia	204432|Acidobacteriia	KLT	Tetratricopeptide repeats	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_11,TPR_16,TPR_2,Trans_reg_C
HKD3_k127_1390814_14	1183438.GKIL_3396	2.183e-56	202.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K02405	ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111	-	-	-	ko00000,ko00001,ko02035,ko03021	-	-	-	Sigma70_ECF
HKD3_k127_1390814_17	1173026.Glo7428_2073	3.253e-44	175.0	COG2931@1|root,COG2931@2|Bacteria,1GB2M@1117|Cyanobacteria	1117|Cyanobacteria	Q	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_1390814_22	929506.CbC4_1324	2.441e-22	101.0	COG2337@1|root,COG2337@2|Bacteria,1VGVY@1239|Firmicutes,25DFK@186801|Clostridia,36N8P@31979|Clostridiaceae	186801|Clostridia	T	PemK-like, MazF-like toxin of type II toxin-antitoxin system	-	-	-	ko:K07171	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PemK_toxin
HKD3_k127_1390814_16	1122604.JONR01000008_gene2129	3.221e-46	179.0	COG1266@1|root,COG1266@2|Bacteria,1NXKQ@1224|Proteobacteria	1224|Proteobacteria	S	CAAX protease self-immunity	-	-	-	-	-	-	-	-	-	-	-	-	Abi
HKD3_k127_1390814_4	82995.CR62_03715	9.684e-185	590.0	COG3104@1|root,COG3104@2|Bacteria,1QXBE@1224|Proteobacteria,1RNVV@1236|Gammaproteobacteria,401XX@613|Serratia	1236|Gammaproteobacteria	E	amino acid peptide transporter	ydgR	-	-	ko:K03305,ko:K06218	-	-	-	-	ko00000,ko02048	2.A.17	-	-	MFS_1,PTR2
HKD3_k127_1390814_0	497964.CfE428DRAFT_6595	3.18e-320	992.0	COG0480@1|root,COG0480@2|Bacteria	2|Bacteria	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA2	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006790,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0030312,GO:0044237,GO:0044464,GO:0071944	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
HKD3_k127_1390814_19	1120965.AUBV01000006_gene2184	9.149e-39	152.0	28H8R@1|root,2Z7KJ@2|Bacteria,4NGZN@976|Bacteroidetes,47NH9@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_1390814_15	483219.LILAB_27650	4.199e-55	207.0	COG2374@1|root,COG2374@2|Bacteria,1RA34@1224|Proteobacteria,42XZM@68525|delta/epsilon subdivisions,2WT9C@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Protein of unknown function (DUF3616)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3616
HKD3_k127_1390814_24	583355.Caka_1871	3.362e-18	89.0	2ERKQ@1|root,33J67@2|Bacteria,46WN1@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_1390814_28	1449049.JONW01000005_gene1996	2.278e-05	48.0	COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,2TU0K@28211|Alphaproteobacteria,2KI57@204458|Caulobacterales	204458|Caulobacterales	C	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,Pyr_redox_dim
HKD3_k127_1390814_13	1366050.N234_10140	1.612e-61	228.0	COG1680@1|root,COG2815@1|root,COG1680@2|Bacteria,COG2815@2|Bacteria,1RIP7@1224|Proteobacteria,2W73Q@28216|Betaproteobacteria,1KDQJ@119060|Burkholderiaceae	28216|Betaproteobacteria	V	TIR domain	-	-	-	-	-	-	-	-	-	-	-	-	TIR_2
HKD3_k127_1390814_26	1192034.CAP_8755	1.738e-10	67.0	COG0782@1|root,COG0782@2|Bacteria,1RAP0@1224|Proteobacteria,42UCT@68525|delta/epsilon subdivisions,2WPAW@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus	greB	-	-	ko:K04760	-	-	-	-	ko00000,ko03021	-	-	-	GreA_GreB,GreA_GreB_N
HKD3_k127_1390814_27	497964.CfE428DRAFT_4858	5.706e-09	59.0	COG0724@1|root,COG0724@2|Bacteria,46VMU@74201|Verrucomicrobia	74201|Verrucomicrobia	S	PFAM RNP-1 like RNA-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	RRM_1
HKD3_k127_1439550_2	1382359.JIAL01000001_gene2085	4.599e-87	294.0	COG1228@1|root,COG1228@2|Bacteria,3Y3BK@57723|Acidobacteria,2JKVY@204432|Acidobacteriia	204432|Acidobacteriia	Q	Amidohydrolase family	hutI	-	3.5.2.7	ko:K01468	ko00340,ko01100,map00340,map01100	M00045	R02288	RC00683	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
HKD3_k127_1439550_0	1122176.KB903542_gene336	3.575e-208	661.0	COG3404@1|root,COG3643@1|root,COG3404@2|Bacteria,COG3643@2|Bacteria,4NFE3@976|Bacteroidetes	976|Bacteroidetes	E	Glutamate formimidoyltransferase	ftcD	-	2.1.2.5,4.3.1.4	ko:K00603,ko:K13990	ko00340,ko00670,ko01100,map00340,map00670,map01100	-	R02287,R02302,R03189	RC00165,RC00221,RC00223,RC00688,RC00870	ko00000,ko00001,ko01000,ko03036,ko04147	-	-	-	FTCD,FTCD_C,FTCD_N
HKD3_k127_1439550_1	234267.Acid_5209	5.778e-194	610.0	COG2987@1|root,COG2987@2|Bacteria,3Y2VD@57723|Acidobacteria	57723|Acidobacteria	E	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate	hutU	-	4.2.1.49	ko:K01712	ko00340,ko01100,map00340,map01100	M00045	R02914	RC00804	ko00000,ko00001,ko00002,ko01000	-	-	-	Urocanase,Urocanase_C,Urocanase_N
HKD3_k127_1509891_1	459495.SPLC1_S208750	9.293e-36	141.0	COG2402@1|root,COG2402@2|Bacteria,1G79E@1117|Cyanobacteria,1HBMU@1150|Oscillatoriales	1117|Cyanobacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
HKD3_k127_1509891_0	1122603.ATVI01000005_gene3498	1.39e-113	393.0	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1SZ6C@1236|Gammaproteobacteria,1XCCV@135614|Xanthomonadales	1236|Gammaproteobacteria	T	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,TPR_19,TPR_2,TPR_8
HKD3_k127_1509891_2	1122604.JONR01000004_gene851	4.189e-21	102.0	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1T234@1236|Gammaproteobacteria,1X903@135614|Xanthomonadales	135614|Xanthomonadales	S	Adenylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16
HKD3_k127_1511011_1	639030.JHVA01000001_gene2743	6.938e-132	426.0	COG1064@1|root,COG1064@2|Bacteria,3Y3X1@57723|Acidobacteria,2JJDF@204432|Acidobacteriia	204432|Acidobacteriia	C	Zinc-binding dehydrogenase	-	-	1.1.1.1	ko:K00001	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
HKD3_k127_1511011_8	1038860.AXAP01000042_gene59	7.842e-13	69.0	COG2133@1|root,COG2133@2|Bacteria,1MVK5@1224|Proteobacteria,2TRN9@28211|Alphaproteobacteria,3JU1E@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Glucose / Sorbosone dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	GSDH
HKD3_k127_1511011_9	536019.Mesop_0803	3.282e-09	57.0	COG2133@1|root,COG2133@2|Bacteria,1MVK5@1224|Proteobacteria,2TRN9@28211|Alphaproteobacteria,43HCJ@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	G	Glucose / Sorbosone dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	GSDH
HKD3_k127_1511011_5	1267533.KB906737_gene1728	1.189e-65	232.0	COG2197@1|root,COG2197@2|Bacteria	2|Bacteria	K	response regulator	-	-	-	ko:K02282	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	GerE,Response_reg
HKD3_k127_1511011_7	497964.CfE428DRAFT_5881	3.762e-55	207.0	COG4585@1|root,COG4585@2|Bacteria,46V1V@74201|Verrucomicrobia	74201|Verrucomicrobia	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA_3
HKD3_k127_1511011_0	497964.CfE428DRAFT_2721	8.709e-239	749.0	COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,46U7Q@74201|Verrucomicrobia	74201|Verrucomicrobia	H	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source	-	-	6.3.5.1	ko:K01950	ko00760,ko01100,map00760,map01100	M00115	R00257	RC00010,RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase,NAD_synthase
HKD3_k127_1511011_3	1163617.SCD_n02152	2.321e-94	316.0	COG0500@1|root,COG2226@2|Bacteria,1MVXN@1224|Proteobacteria,2VQVG@28216|Betaproteobacteria	28216|Betaproteobacteria	Q	Methyltransferase type 11	arsM	-	2.1.1.137	ko:K07755	-	-	-	-	ko00000,ko01000	-	-	-	Methyltransf_31
HKD3_k127_1511011_4	452637.Oter_2612	3.552e-67	239.0	COG0457@1|root,COG0457@2|Bacteria,46VCW@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Protein of unknown function (DUF2911)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2911
HKD3_k127_1511011_6	1380354.JIAN01000006_gene425	1.659e-56	201.0	COG3157@1|root,COG3157@2|Bacteria,2IP19@201174|Actinobacteria	201174|Actinobacteria	S	Type VI secretion system effector, Hcp	-	-	-	ko:K11903	ko02025,ko03070,map02025,map03070	M00334	-	-	ko00000,ko00001,ko00002,ko02044	-	-	-	T6SS_HCP
HKD3_k127_1511011_2	1288494.EBAPG3_5720	1.179e-113	380.0	COG0457@1|root,COG4976@1|root,COG0457@2|Bacteria,COG4976@2|Bacteria,1MVMG@1224|Proteobacteria,2WH7Y@28216|Betaproteobacteria,372FY@32003|Nitrosomonadales	28216|Betaproteobacteria	H	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_11
HKD3_k127_1581369_1	398512.JQKC01000010_gene5	2.737e-15	90.0	COG0348@1|root,COG0348@2|Bacteria,1TRZZ@1239|Firmicutes,24A2P@186801|Clostridia,3WNCH@541000|Ruminococcaceae	186801|Clostridia	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_5,Fer4_9
HKD3_k127_1581369_0	1283300.ATXB01000002_gene2888	4.659e-53	195.0	2DP87@1|root,330Z8@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_1599217_5	497964.CfE428DRAFT_2462	2.059e-126	410.0	COG0105@1|root,COG0105@2|Bacteria,46T8K@74201|Verrucomicrobia	74201|Verrucomicrobia	F	Nucleoside diphosphate kinase	ndk	-	2.7.4.6	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	M00049,M00050,M00052,M00053	R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895	RC00002	ko00000,ko00001,ko00002,ko01000,ko04131	-	-	-	NDK
HKD3_k127_1599217_1	497964.CfE428DRAFT_2463	2.499e-191	603.0	COG0436@1|root,COG0436@2|Bacteria,46S4M@74201|Verrucomicrobia	74201|Verrucomicrobia	E	aminotransferase class I and II	-	-	2.6.1.1	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
HKD3_k127_1599217_0	497964.CfE428DRAFT_2513	2.363e-204	648.0	COG1543@1|root,COG1543@2|Bacteria	2|Bacteria	G	Belongs to the glycosyl hydrolase 57 family	-	-	2.4.1.18	ko:K03406,ko:K16149	ko00500,ko01100,ko01110,ko02020,ko02030,map00500,map01100,map01110,map02020,map02030	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko02035	-	GH57	-	DUF1957,Glyco_hydro_57,Glyco_transf_4,Glycos_transf_1
HKD3_k127_1599217_2	1396418.BATQ01000046_gene6169	1.897e-177	569.0	COG0764@1|root,COG0774@1|root,COG0764@2|Bacteria,COG0774@2|Bacteria,46SG1@74201|Verrucomicrobia,2ITYH@203494|Verrucomicrobiae	203494|Verrucomicrobiae	IM	Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis	fabZ	-	3.5.1.108,4.2.1.59	ko:K16363	ko00061,ko00540,ko01100,ko01212,map00061,map00540,map01100,map01212	M00060,M00083	R04428,R04535,R04537,R04544,R04568,R04587,R04954,R04965	RC00166,RC00300,RC00831,RC01095	ko00000,ko00001,ko00002,ko01000,ko01004,ko01005	-	-	-	FabA,LpxC
HKD3_k127_1599217_6	497964.CfE428DRAFT_4114	1.681e-111	365.0	COG1043@1|root,COG1043@2|Bacteria,46SD4@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxA	-	2.3.1.129	ko:K00677	ko00540,ko01100,ko01503,map00540,map01100,map01503	M00060	R04567	RC00039,RC00055	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Acetyltransf_11,Hexapep
HKD3_k127_1599217_3	1396141.BATP01000019_gene1607	1.675e-175	566.0	COG0497@1|root,COG0497@2|Bacteria,46SGB@74201|Verrucomicrobia,2IU0W@203494|Verrucomicrobiae	203494|Verrucomicrobiae	L	RecF/RecN/SMC N terminal domain	-	-	-	ko:K03631	-	-	-	-	ko00000,ko03400	-	-	-	SMC_N
HKD3_k127_1599217_13	247490.KSU1_D0778	5.554e-30	122.0	COG0614@1|root,COG0614@2|Bacteria,2J06G@203682|Planctomycetes	203682|Planctomycetes	P	PD-(D/E)XK nuclease superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_3
HKD3_k127_1599217_16	457424.BFAG_02363	2.48e-09	62.0	COG0614@1|root,COG0614@2|Bacteria,4NRGG@976|Bacteroidetes,2FT59@200643|Bacteroidia,4AREE@815|Bacteroidaceae	976|Bacteroidetes	P	PD-(D/E)XK nuclease superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_3
HKD3_k127_1599217_10	497964.CfE428DRAFT_1264	1.869e-79	271.0	COG1584@1|root,COG1584@2|Bacteria,46T3N@74201|Verrucomicrobia	74201|Verrucomicrobia	S	PFAM GPR1 FUN34 yaaH family protein	-	-	-	ko:K07034	-	-	-	-	ko00000	-	-	-	Grp1_Fun34_YaaH
HKD3_k127_1599217_4	497964.CfE428DRAFT_6235	1.136e-138	451.0	COG0446@1|root,COG0446@2|Bacteria,46SG9@74201|Verrucomicrobia	2|Bacteria	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.7.1.15	ko:K00362,ko:K07001	ko00910,ko01120,map00910,map01120	M00530	R00787	RC00176	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF3734,Patatin,Pyr_redox_2,Reductase_C
HKD3_k127_1599217_15	497964.CfE428DRAFT_5650	6.988e-19	93.0	2EGRU@1|root,33AI0@2|Bacteria,46WFI@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_1599217_7	118173.KB235914_gene2445	6.676e-91	306.0	COG4870@1|root,COG4870@2|Bacteria,1G85R@1117|Cyanobacteria,1H9NA@1150|Oscillatoriales	1117|Cyanobacteria	O	PFAM Papain family cysteine protease	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C1
HKD3_k127_1599217_11	533240.CRC_03116	1.563e-64	230.0	COG0500@1|root,COG0500@2|Bacteria,1G8N3@1117|Cyanobacteria	1117|Cyanobacteria	Q	Nodulation protein S (NodS)	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
HKD3_k127_1599217_17	1280692.AUJL01000019_gene936	0.0003797	46.0	2BE7V@1|root,327YV@2|Bacteria,1UTVX@1239|Firmicutes,254K5@186801|Clostridia,36TRY@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_1599217_12	1184267.A11Q_1123	6.196e-43	166.0	COG0251@1|root,COG0251@2|Bacteria,1MZ3J@1224|Proteobacteria,42TSD@68525|delta/epsilon subdivisions,2MT9J@213481|Bdellovibrionales,2WQ6E@28221|Deltaproteobacteria	213481|Bdellovibrionales	J	PFAM Endoribonuclease L-PSP	-	-	3.5.99.10	ko:K09022	-	-	R11098,R11099	RC03275,RC03354	ko00000,ko01000	-	-	-	Ribonuc_L-PSP
HKD3_k127_1599217_8	497964.CfE428DRAFT_1521	2.974e-85	288.0	COG0461@1|root,COG0461@2|Bacteria,46SZV@74201|Verrucomicrobia	74201|Verrucomicrobia	F	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)	pyrE	-	2.4.2.10	ko:K00762	ko00240,ko01100,map00240,map01100	M00051	R01870	RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran
HKD3_k127_1599217_9	1118054.CAGW01000053_gene1386	8.66e-82	274.0	COG0179@1|root,COG0179@2|Bacteria,1VRIW@1239|Firmicutes,4HUFK@91061|Bacilli,26U89@186822|Paenibacillaceae	91061|Bacilli	Q	Fumarylacetoacetase N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	FAA_hydrolase,FAA_hydrolase_N
HKD3_k127_1616231_5	208444.JNYY01000030_gene1157	2.408e-49	192.0	COG0500@1|root,COG2226@2|Bacteria,2H2IP@201174|Actinobacteria,4E9A2@85010|Pseudonocardiales	201174|Actinobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_12
HKD3_k127_1616231_7	1163408.UU9_14505	7.507e-16	81.0	COG0764@1|root,COG0764@2|Bacteria,1NGGK@1224|Proteobacteria,1SJ6T@1236|Gammaproteobacteria,1X85H@135614|Xanthomonadales	135614|Xanthomonadales	I	3-hydroxymyristoyl 3-hydroxydecanoyl-(acyl carrier protein)	-	-	-	-	-	-	-	-	-	-	-	-	FabA,PS-DH
HKD3_k127_1616231_1	443144.GM21_2187	1.704e-85	300.0	COG0446@1|root,COG0446@2|Bacteria,1QXXG@1224|Proteobacteria	1224|Proteobacteria	S	Sulfotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_3
HKD3_k127_1616231_2	485913.Krac_12208	2.7e-78	263.0	COG0225@1|root,COG0225@2|Bacteria	2|Bacteria	O	peptide-methionine (S)-S-oxide reductase activity	msrA	-	1.8.4.11,1.8.4.12	ko:K07304,ko:K07305,ko:K12267	-	-	-	-	ko00000,ko01000	-	-	-	PMSR
HKD3_k127_1616231_4	497964.CfE428DRAFT_5918	1.687e-69	243.0	COG0363@1|root,COG0363@2|Bacteria,46T8I@74201|Verrucomicrobia	74201|Verrucomicrobia	G	Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase	nagB	-	3.1.1.31	ko:K01057	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200	M00004,M00006,M00008	R02035	RC00537	ko00000,ko00001,ko00002,ko01000	-	-	-	Glucosamine_iso
HKD3_k127_1616231_0	497964.CfE428DRAFT_5278	6.883e-165	526.0	COG0451@1|root,COG0451@2|Bacteria,46TDU@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Male sterility protein	-	-	5.1.3.10	ko:K12454	ko00520,map00520	-	R04266	RC00528	ko00000,ko00001,ko01000	-	-	-	Epimerase
HKD3_k127_1616231_3	497964.CfE428DRAFT_0749	9.581e-75	259.0	COG0327@1|root,COG0327@2|Bacteria	2|Bacteria	L	Belongs to the GTP cyclohydrolase I type 2 NIF3 family	ybgI	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009314,GO:0009628,GO:0010212,GO:0042802,GO:0043167,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0050896	3.5.4.16	ko:K22391	ko00790,ko01100,map00790,map01100	M00126	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	-	NIF3
HKD3_k127_163057_2	585530.HMPREF0183_0092	1.765e-15	85.0	COG3276@1|root,COG3276@2|Bacteria,2GKF9@201174|Actinobacteria,4F8B3@85019|Brevibacteriaceae	201174|Actinobacteria	J	Elongation factor SelB, winged helix	selB	-	-	ko:K03833	-	-	-	-	ko00000,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,SelB-wing_2,SelB-wing_3
HKD3_k127_163057_0	1123070.KB899248_gene241	6.863e-122	407.0	COG1921@1|root,COG1921@2|Bacteria	2|Bacteria	E	L-seryl-tRNASec selenium transferase activity	selA	GO:0003674,GO:0003824,GO:0004125,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009059,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016070,GO:0016259,GO:0016260,GO:0016740,GO:0016785,GO:0018130,GO:0019438,GO:0019752,GO:0019842,GO:0030170,GO:0032774,GO:0034641,GO:0034654,GO:0034660,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0090304,GO:0097056,GO:0097159,GO:0140098,GO:0140101,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.9.1.1	ko:K01042	ko00450,ko00970,map00450,map00970	-	R08219	RC01246	ko00000,ko00001,ko01000	-	-	iECP_1309.ECP_3693,iSbBS512_1146.SbBS512_E4006	Se-cys_synth_N,SelA
HKD3_k127_163057_1	1123070.KB899250_gene603	4.835e-78	269.0	COG0709@1|root,COG0709@2|Bacteria	2|Bacteria	E	selenide, water dikinase activity	selD	-	2.7.9.3,2.8.1.7	ko:K01008,ko:K04487	ko00450,ko00730,ko01100,ko04122,map00450,map00730,map01100,map04122	-	R03595,R07460,R11528,R11529	RC00002,RC01789,RC02313,RC02878	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	AIRS,AIRS_C,Pyr_redox_2
HKD3_k127_1633520_36	497964.CfE428DRAFT_0879	5.002e-06	50.0	COG3494@1|root,COG3494@2|Bacteria,46SJ6@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Protein of unknown function (DUF1009)	-	-	-	ko:K09949	-	-	-	-	ko00000	-	-	-	DUF1009
HKD3_k127_1633520_29	497964.CfE428DRAFT_4487	2.677e-35	138.0	COG0355@1|root,COG0355@2|Bacteria,46T0F@74201|Verrucomicrobia	74201|Verrucomicrobia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpC	-	-	ko:K02114	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_DE,ATP-synt_DE_N
HKD3_k127_1633520_0	497964.CfE428DRAFT_4489	2.853e-254	789.0	COG0055@1|root,COG0055@2|Bacteria,46SCC@74201|Verrucomicrobia	74201|Verrucomicrobia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits	atpD	-	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_N
HKD3_k127_1633520_14	497964.CfE428DRAFT_4490	7.983e-103	342.0	COG0224@1|root,COG0224@2|Bacteria,46SGU@74201|Verrucomicrobia	74201|Verrucomicrobia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex	atpG	-	-	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt
HKD3_k127_1633520_2	497964.CfE428DRAFT_4491	6.487e-246	767.0	COG0056@1|root,COG0056@2|Bacteria,46SB5@74201|Verrucomicrobia	74201|Verrucomicrobia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	atpA	-	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
HKD3_k127_1633520_28	497964.CfE428DRAFT_4492	8.629e-39	149.0	COG0712@1|root,COG0712@2|Bacteria,46TC4@74201|Verrucomicrobia	74201|Verrucomicrobia	C	ATP synthase delta (OSCP) subunit	atpH	-	-	ko:K02113	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	OSCP
HKD3_k127_1633520_26	497964.CfE428DRAFT_4493	3.197e-48	179.0	COG0711@1|root,COG0711@2|Bacteria,46SYI@74201|Verrucomicrobia	74201|Verrucomicrobia	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpF	-	-	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_B
HKD3_k127_1633520_33	497964.CfE428DRAFT_4494	5.008e-18	85.0	2DS8G@1|root,33EZT@2|Bacteria,46T9M@74201|Verrucomicrobia	74201|Verrucomicrobia	S	ATP synthase subunit C	-	-	-	ko:K02110	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_C
HKD3_k127_1633520_15	497964.CfE428DRAFT_4495	2.835e-96	325.0	COG0356@1|root,COG0356@2|Bacteria,46SVZ@74201|Verrucomicrobia	74201|Verrucomicrobia	C	it plays a direct role in the translocation of protons across the membrane	atpB	-	-	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1	-	-	ATP-synt_A
HKD3_k127_1633520_10	497964.CfE428DRAFT_4498	1.713e-135	443.0	COG0438@1|root,COG0438@2|Bacteria,46TUX@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
HKD3_k127_1633520_12	1396141.BATP01000017_gene2771	6.144e-123	404.0	COG0536@1|root,COG0536@2|Bacteria,46SBS@74201|Verrucomicrobia,2ITSD@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control	obg	-	-	ko:K03979	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	GTP1_OBG,MMR_HSR1
HKD3_k127_1633520_6	497964.CfE428DRAFT_0835	2.064e-174	556.0	COG0297@1|root,COG0297@2|Bacteria,46Z3D@74201|Verrucomicrobia	74201|Verrucomicrobia	G	Glycosyl transferase 4-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
HKD3_k127_1633520_27	861299.J421_4362	2.489e-42	162.0	COG0589@1|root,COG0589@2|Bacteria,1ZTUZ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD3_k127_1633520_3	497964.CfE428DRAFT_0016	2.522e-231	722.0	COG1914@1|root,COG1914@2|Bacteria,46SH7@74201|Verrucomicrobia	74201|Verrucomicrobia	P	H( )-stimulated, divalent metal cation uptake system	mntH	-	-	ko:K03322	-	-	-	-	ko00000,ko02000	2.A.55.2.6,2.A.55.3	-	-	Nramp
HKD3_k127_1633520_23	497964.CfE428DRAFT_0017	2.19e-58	206.0	COG1321@1|root,COG1321@2|Bacteria,46VZN@74201|Verrucomicrobia	74201|Verrucomicrobia	K	Helix-turn-helix diphteria tox regulatory element	-	-	-	-	-	-	-	-	-	-	-	-	Fe_dep_repr_C,Fe_dep_repress
HKD3_k127_1633520_9	1403819.BATR01000162_gene5348	1.254e-144	472.0	COG1253@1|root,COG1253@2|Bacteria,46SMD@74201|Verrucomicrobia,2IU23@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	PFAM CBS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
HKD3_k127_1633520_30	1403819.BATR01000162_gene5349	1.345e-33	134.0	COG0199@1|root,COG0199@2|Bacteria,46TBH@74201|Verrucomicrobia,2IUM9@203494|Verrucomicrobiae	203494|Verrucomicrobiae	J	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site	rpsN	-	-	ko:K02954	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S14
HKD3_k127_1633520_19	1396418.BATQ01000119_gene3117	1.668e-86	295.0	COG1273@1|root,COG1273@2|Bacteria,46SB0@74201|Verrucomicrobia,2IVP3@203494|Verrucomicrobiae	203494|Verrucomicrobiae	L	Ku70/Ku80 beta-barrel domain	-	-	-	-	-	-	-	-	-	-	-	-	Ku
HKD3_k127_1633520_34	497964.CfE428DRAFT_2589	5.271e-16	83.0	COG1826@1|root,COG1826@2|Bacteria,46WPX@74201|Verrucomicrobia	74201|Verrucomicrobia	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system	tatA	-	-	ko:K03116	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
HKD3_k127_1633520_31	497964.CfE428DRAFT_5379	2.12e-27	119.0	COG0236@1|root,COG0236@2|Bacteria,46TAW@74201|Verrucomicrobia	74201|Verrucomicrobia	IQ	Phosphopantetheine attachment site	-	-	-	-	-	-	-	-	-	-	-	-	PP-binding
HKD3_k127_1633520_21	1116472.MGMO_138c00220	9.047e-78	274.0	COG0438@1|root,COG0438@2|Bacteria,1MU9C@1224|Proteobacteria,1RXGH@1236|Gammaproteobacteria,1XG2N@135618|Methylococcales	135618|Methylococcales	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_1
HKD3_k127_1633520_13	497964.CfE428DRAFT_5385	3.708e-119	394.0	COG1611@1|root,COG1611@2|Bacteria,46SEG@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Possible lysine decarboxylase	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
HKD3_k127_1633520_20	497964.CfE428DRAFT_6544	3.357e-83	286.0	COG0596@1|root,COG0596@2|Bacteria	2|Bacteria	S	hydrolase activity, acting on ester bonds	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
HKD3_k127_1633520_32	497964.CfE428DRAFT_5369	2.544e-18	92.0	2C7SB@1|root,2ZTDJ@2|Bacteria,46WHI@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_1633520_7	485913.Krac_7237	4.476e-164	528.0	COG1262@1|root,COG1262@2|Bacteria,2G89M@200795|Chloroflexi	200795|Chloroflexi	S	Sulfatase-modifying factor enzyme 1	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2,FGE-sulfatase
HKD3_k127_1633520_16	316274.Haur_0996	7.093e-92	319.0	COG4301@1|root,COG4301@2|Bacteria,2G81E@200795|Chloroflexi	200795|Chloroflexi	S	Histidine-specific methyltransferase, SAM-dependent	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_33
HKD3_k127_1633520_17	105559.Nwat_2548	3.714e-90	304.0	COG1125@1|root,COG1125@2|Bacteria,1QTUC@1224|Proteobacteria,1RQWQ@1236|Gammaproteobacteria,1WXWK@135613|Chromatiales	135613|Chromatiales	E	pfam abc	-	-	-	ko:K05847	ko02010,map02010	M00209	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	ABC_tran
HKD3_k127_1633520_8	661478.OP10G_1720	3.079e-163	530.0	COG1174@1|root,COG1732@1|root,COG1174@2|Bacteria,COG1732@2|Bacteria	2|Bacteria	M	glycine betaine transport	yehZ	-	-	ko:K05845,ko:K05846	ko02010,map02010	M00209	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	BPD_transp_1,OpuAC
HKD3_k127_1633520_5	402777.KB235904_gene3348	2.093e-177	567.0	COG1012@1|root,COG1012@2|Bacteria,1G046@1117|Cyanobacteria,1H7Q6@1150|Oscillatoriales	1117|Cyanobacteria	C	PFAM Aldehyde dehydrogenase	gabD	-	1.2.1.16,1.2.1.20,1.2.1.79	ko:K00135	ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120	M00027	R00713,R00714,R02401	RC00080	ko00000,ko00001,ko00002,ko01000	-	-	iECDH10B_1368.gabD,iJN678.gabD	Aldedh
HKD3_k127_1633520_1	1260251.SPISAL_07325	4.816e-249	782.0	COG0529@1|root,COG2046@1|root,COG0529@2|Bacteria,COG2046@2|Bacteria,1MX0D@1224|Proteobacteria,1RNWT@1236|Gammaproteobacteria,1X2EG@135613|Chromatiales	135613|Chromatiales	P	PUA-like domain	-	-	2.7.7.4	ko:K00958	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00529,R04929	RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	APS_kinase,ATP-sulfurylase,PUA_2
HKD3_k127_1633520_18	497964.CfE428DRAFT_3884	1.237e-89	297.0	COG0377@1|root,COG0377@2|Bacteria,46SMM@74201|Verrucomicrobia	74201|Verrucomicrobia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoB	-	1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q6
HKD3_k127_1633520_22	497964.CfE428DRAFT_3883	2.296e-69	240.0	COG0852@1|root,COG0852@2|Bacteria,46STM@74201|Verrucomicrobia	74201|Verrucomicrobia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoC	-	1.6.5.3	ko:K00332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa
HKD3_k127_1633520_4	497964.CfE428DRAFT_6336	6.151e-201	640.0	COG1480@1|root,COG1480@2|Bacteria,46S4P@74201|Verrucomicrobia	74201|Verrucomicrobia	S	7TM receptor with intracellular HD hydrolase	-	-	-	ko:K07037	-	-	-	-	ko00000	-	-	-	7TM-7TMR_HD,HD
HKD3_k127_1633520_11	497964.CfE428DRAFT_6337	1.17e-131	427.0	COG1702@1|root,COG1702@2|Bacteria,46S7S@74201|Verrucomicrobia	74201|Verrucomicrobia	T	PhoH-like protein	-	-	-	ko:K06217	-	-	-	-	ko00000	-	-	-	PhoH
HKD3_k127_1633520_24	497964.CfE428DRAFT_6338	7.5e-52	188.0	2FDFS@1|root,345HD@2|Bacteria,46W4Y@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_1633520_25	497964.CfE428DRAFT_6339	1.042e-49	187.0	2F4CA@1|root,342S4@2|Bacteria,46VXA@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_1637997_2	1123073.KB899243_gene600	1.616e-25	113.0	2EH9H@1|root,33B1D@2|Bacteria,1NV7J@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_1637997_1	452637.Oter_3121	5.187e-48	175.0	COG3791@1|root,COG3791@2|Bacteria,46T3T@74201|Verrucomicrobia	74201|Verrucomicrobia	S	PFAM glutathione-dependent formaldehyde-activating GFA	-	-	-	-	-	-	-	-	-	-	-	-	GFA
HKD3_k127_1637997_0	204669.Acid345_1151	1.289e-199	632.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,3Y3NT@57723|Acidobacteria,2JIBK@204432|Acidobacteriia	204432|Acidobacteriia	EU	Dipeptidyl peptidase IV (DPP IV) N-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	DPPIV_N,PD40,Peptidase_S9
HKD3_k127_1689516_3	1403819.BATR01000010_gene397	5.598e-18	94.0	COG2885@1|root,COG2885@2|Bacteria,46T6J@74201|Verrucomicrobia,2IUNT@203494|Verrucomicrobiae	203494|Verrucomicrobiae	M	OmpA family	-	-	-	-	-	-	-	-	-	-	-	-	OmpA
HKD3_k127_1689516_0	497964.CfE428DRAFT_0875	3.768e-99	329.0	COG0413@1|root,COG0413@2|Bacteria,46SPN@74201|Verrucomicrobia	74201|Verrucomicrobia	H	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate	panB	-	2.1.2.11	ko:K00606	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R01226	RC00022,RC00200	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_transf
HKD3_k127_1689516_2	497964.CfE428DRAFT_0874	3.853e-45	169.0	COG0801@1|root,COG0801@2|Bacteria,46T2Z@74201|Verrucomicrobia	74201|Verrucomicrobia	H	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK)	folK	-	2.7.6.3	ko:K00950	ko00790,ko01100,map00790,map01100	M00126,M00841	R03503	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	HPPK
HKD3_k127_1689516_1	240016.ABIZ01000001_gene2099	1.013e-65	231.0	COG0289@1|root,COG0289@2|Bacteria,46SPR@74201|Verrucomicrobia,2IU1I@203494|Verrucomicrobiae	203494|Verrucomicrobiae	E	Dihydrodipicolinate reductase, N-terminus	dapB	-	1.17.1.8	ko:K00215	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R04198,R04199	RC00478	ko00000,ko00001,ko00002,ko01000	-	-	-	DapB_C,DapB_N
HKD3_k127_170242_0	452637.Oter_2821	1.171e-173	558.0	COG0755@1|root,COG0755@2|Bacteria,46SIH@74201|Verrucomicrobia,3K7UF@414999|Opitutae	414999|Opitutae	O	PFAM cytochrome c assembly protein	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C_asm
HKD3_k127_1717130_0	700598.Niako_2565	1.085e-170	539.0	COG3185@1|root,COG3185@2|Bacteria,4NFI7@976|Bacteroidetes,1IPBI@117747|Sphingobacteriia	976|Bacteroidetes	E	4-hydroxyphenylpyruvate dioxygenase	hppD	-	1.13.11.27	ko:K00457	ko00130,ko00350,ko00360,ko01100,map00130,map00350,map00360,map01100	M00044	R01372,R02521	RC00505,RC00738	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Glyoxalase
HKD3_k127_1717130_1	886293.Sinac_1066	1.169e-153	494.0	COG3508@1|root,COG3508@2|Bacteria,2J1YX@203682|Planctomycetes	203682|Planctomycetes	Q	homogentisate 1,2-dioxygenase	-	-	1.13.11.5	ko:K00451	ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120	M00044	R02519	RC00737	ko00000,ko00001,ko00002,ko01000	-	-	-	HgmA
HKD3_k127_1717130_2	1122604.JONR01000033_gene37	3.372e-74	254.0	COG0302@1|root,COG0302@2|Bacteria,1MY3N@1224|Proteobacteria,1RMQM@1236|Gammaproteobacteria,1X3YF@135614|Xanthomonadales	135614|Xanthomonadales	F	GTP cyclohydrolase	folE	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003933,GO:0003934,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006066,GO:0006725,GO:0006729,GO:0006732,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009108,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019238,GO:0019438,GO:0019751,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034311,GO:0034312,GO:0034641,GO:0035639,GO:0036094,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	3.5.4.16	ko:K01495	ko00790,ko01100,map00790,map01100	M00126,M00841,M00842,M00843	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	-	GTP_cyclohydroI
HKD3_k127_1717130_3	710685.MycrhN_0181	3.667e-24	103.0	2BVXR@1|root,32QYG@2|Bacteria,2I832@201174|Actinobacteria,23FJM@1762|Mycobacteriaceae	201174|Actinobacteria	S	DoxX	-	-	-	-	-	-	-	-	-	-	-	-	DoxX
HKD3_k127_1717633_0	452637.Oter_2583	2.641e-77	262.0	COG3005@1|root,COG3005@2|Bacteria	2|Bacteria	C	denitrification pathway	omcI	-	-	-	-	-	-	-	-	-	-	-	Paired_CXXCH_1
HKD3_k127_1758346_5	1396418.BATQ01000049_gene427	1.511e-212	672.0	COG1012@1|root,COG1012@2|Bacteria,46TX0@74201|Verrucomicrobia,2IUT7@203494|Verrucomicrobiae	203494|Verrucomicrobiae	C	Aldehyde dehydrogenase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldedh
HKD3_k127_1758346_8	1403819.BATR01000093_gene2833	1.133e-176	565.0	COG0160@1|root,COG0160@2|Bacteria	2|Bacteria	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	lat	-	2.6.1.11,2.6.1.17,2.6.1.19,2.6.1.22,2.6.1.36	ko:K00821,ko:K03918,ko:K07250,ko:K13524	ko00220,ko00250,ko00280,ko00300,ko00410,ko00640,ko00650,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,ko04727,map00220,map00250,map00280,map00300,map00410,map00640,map00650,map01100,map01110,map01120,map01130,map01210,map01230,map04727	M00016,M00027,M00028,M00845	R00457,R00908,R01648,R02283,R04188,R04475	RC00006,RC00062,RC00160	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	iNJ661.Rv3290c	Aminotran_3
HKD3_k127_1758346_4	497964.CfE428DRAFT_5143	1.477e-233	739.0	COG1960@1|root,COG1960@2|Bacteria,46TJY@74201|Verrucomicrobia	74201|Verrucomicrobia	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HKD3_k127_1758346_7	497964.CfE428DRAFT_5144	3.617e-183	597.0	COG1250@1|root,COG1250@2|Bacteria,46U5Q@74201|Verrucomicrobia	74201|Verrucomicrobia	I	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	3HCDH,3HCDH_N,ECH_1
HKD3_k127_1758346_0	1340493.JNIF01000004_gene135	0.0	1131.0	COG0474@1|root,COG0474@2|Bacteria,3Y3ZX@57723|Acidobacteria	57723|Acidobacteria	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.2,3.6.3.6	ko:K01531,ko:K01535	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.3.3,3.A.3.4	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
HKD3_k127_1758346_16	756067.MicvaDRAFT_2865	1.874e-115	381.0	COG2234@1|root,COG2234@2|Bacteria,1G1QW@1117|Cyanobacteria,1H7N7@1150|Oscillatoriales	1117|Cyanobacteria	S	PFAM Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
HKD3_k127_1758346_19	1267534.KB906755_gene4489	3.314e-82	286.0	COG0842@1|root,COG0842@2|Bacteria,3Y4H7@57723|Acidobacteria,2JN2Y@204432|Acidobacteriia	204432|Acidobacteriia	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
HKD3_k127_1758346_15	661478.OP10G_2908	1.434e-115	380.0	COG1131@1|root,COG1131@2|Bacteria	2|Bacteria	V	ATPase activity	ybhF-C	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
HKD3_k127_1758346_29	909663.KI867150_gene2915	8.939e-30	130.0	COG1566@1|root,COG1566@2|Bacteria,1QU7Z@1224|Proteobacteria,43BPM@68525|delta/epsilon subdivisions,2X70W@28221|Deltaproteobacteria,2MSKN@213462|Syntrophobacterales	28221|Deltaproteobacteria	V	HlyD family secretion protein	-	-	-	ko:K01993	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
HKD3_k127_1758346_24	706587.Desti_3800	5.536e-60	214.0	COG1309@1|root,COG1309@2|Bacteria,1NAQF@1224|Proteobacteria,42S96@68525|delta/epsilon subdivisions	1224|Proteobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
HKD3_k127_1758346_32	338963.Pcar_3377	1.204e-17	90.0	2EMJ2@1|root,33F7N@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_1758346_27	335543.Sfum_1510	2.766e-34	142.0	2DQW0@1|root,3390A@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_1758346_1	497964.CfE428DRAFT_0990	1.108e-279	872.0	COG0514@1|root,COG0514@2|Bacteria,46S7V@74201|Verrucomicrobia	74201|Verrucomicrobia	L	TIGRFAM ATP-dependent DNA helicase, RecQ family	-	-	3.6.4.12	ko:K03654	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,HRDC,Helicase_C,RQC,RecQ_Zn_bind
HKD3_k127_1758346_26	335543.Sfum_1510	4.985e-38	153.0	2DQW0@1|root,3390A@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_1758346_31	395961.Cyan7425_0783	4.994e-24	119.0	COG0265@1|root,COG0457@1|root,COG0265@2|Bacteria,COG0457@2|Bacteria,1G7ID@1117|Cyanobacteria,3KHZI@43988|Cyanothece	1117|Cyanobacteria	O	Peptidase S1 and S6 chymotrypsin Hap	-	-	-	-	-	-	-	-	-	-	-	-	GUN4,TPR_1,TPR_11,TPR_8,Trypsin_2
HKD3_k127_1758346_38	1280390.CBQR020000083_gene1798	1.498e-05	54.0	28Q2E@1|root,2ZCKD@2|Bacteria,1V260@1239|Firmicutes	1239|Firmicutes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_1758346_33	113395.AXAI01000018_gene4848	1.101e-15	87.0	COG2358@1|root,COG2358@2|Bacteria,1MXW1@1224|Proteobacteria,2TSK2@28211|Alphaproteobacteria,3JZ7W@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	NMT1-like family	imp	-	-	ko:K07080	-	-	-	-	ko00000	-	-	-	NMT1_3
HKD3_k127_1758346_34	1396418.BATQ01000054_gene3	1.398e-13	74.0	2E3X5@1|root,32YUB@2|Bacteria,46WYM@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Protein of unknwon function (DUF3008)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3008
HKD3_k127_1758346_6	886293.Sinac_0988	4.573e-200	634.0	COG0531@1|root,COG0531@2|Bacteria,2IX7G@203682|Planctomycetes	203682|Planctomycetes	E	Amino acid permease	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
HKD3_k127_1758346_21	562970.Btus_2819	6.695e-77	265.0	COG1540@1|root,COG1540@2|Bacteria,1TR8X@1239|Firmicutes,4H9PF@91061|Bacilli,278U8@186823|Alicyclobacillaceae	91061|Bacilli	S	Belongs to the UPF0271 (lamB) family	ycsF	-	-	ko:K07160	-	-	-	-	ko00000	-	-	-	LamB_YcsF
HKD3_k127_1758346_14	794903.OPIT5_04825	2.082e-128	430.0	COG1984@1|root,COG2049@1|root,COG1984@2|Bacteria,COG2049@2|Bacteria,46VNA@74201|Verrucomicrobia,3K9I8@414999|Opitutae	414999|Opitutae	E	Allophanate hydrolase subunit 2	-	-	-	-	-	-	-	-	-	-	-	-	CT_A_B
HKD3_k127_1758346_30	521098.Aaci_0861	6.018e-29	127.0	COG2353@1|root,COG2353@2|Bacteria,1V1NX@1239|Firmicutes,4HFXF@91061|Bacilli	91061|Bacilli	S	Belongs to the UPF0312 family	-	-	-	-	-	-	-	-	-	-	-	-	YceI
HKD3_k127_1758346_25	497964.CfE428DRAFT_4583	9.29e-55	197.0	COG1381@1|root,COG1381@2|Bacteria,46VUW@74201|Verrucomicrobia	74201|Verrucomicrobia	L	Involved in DNA repair and RecF pathway recombination	recO	-	-	ko:K03584	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecO_C,RecO_N
HKD3_k127_1758346_18	1128421.JAGA01000002_gene1937	1.974e-94	324.0	COG0477@1|root,COG2814@2|Bacteria,2NS3M@2323|unclassified Bacteria	2|Bacteria	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
HKD3_k127_1758346_10	264462.Bd2731	3.868e-164	528.0	COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,42N8Y@68525|delta/epsilon subdivisions,2MSPX@213481|Bdellovibrionales,2WIR7@28221|Deltaproteobacteria	213481|Bdellovibrionales	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation	lpdA-1	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
HKD3_k127_1758346_36	204669.Acid345_3240	1.794e-08	65.0	COG1266@1|root,COG1266@2|Bacteria,3Y5CJ@57723|Acidobacteria,2JJVP@204432|Acidobacteriia	204432|Acidobacteriia	S	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
HKD3_k127_1758346_12	497964.CfE428DRAFT_2638	1.475e-135	444.0	COG0508@1|root,COG0508@2|Bacteria,46SD3@74201|Verrucomicrobia	74201|Verrucomicrobia	C	The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2)	sucB	-	2.3.1.61	ko:K00658	ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R02570,R02571,R08549	RC00004,RC02727,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
HKD3_k127_1758346_20	497964.CfE428DRAFT_2346	7.469e-81	278.0	COG3694@1|root,COG3694@2|Bacteria,46VPX@74201|Verrucomicrobia	74201|Verrucomicrobia	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_6
HKD3_k127_1758346_13	497964.CfE428DRAFT_5021	1.531e-131	430.0	COG0845@1|root,COG0845@2|Bacteria,46TJP@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	HlyD_D23
HKD3_k127_1758346_17	452637.Oter_3644	1.455e-99	331.0	COG1136@1|root,COG1136@2|Bacteria,46SKR@74201|Verrucomicrobia,3K7HB@414999|Opitutae	414999|Opitutae	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD3_k127_1758346_9	497964.CfE428DRAFT_5023	7.992e-165	527.0	COG0577@1|root,COG0577@2|Bacteria,46U7K@74201|Verrucomicrobia	74201|Verrucomicrobia	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HKD3_k127_1758346_28	1173263.Syn7502_02560	2.062e-33	132.0	COG2897@1|root,COG2897@2|Bacteria	2|Bacteria	P	thiosulfate sulfurtransferase activity	-	-	2.8.1.1,2.8.1.2	ko:K01011	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko01000	-	-	-	Rhodanese
HKD3_k127_1758346_2	479434.Sthe_2668	1.632e-259	835.0	COG4447@1|root,COG4447@2|Bacteria,2G678@200795|Chloroflexi,27YSS@189775|Thermomicrobia	189775|Thermomicrobia	S	PFAM glycosyl hydrolase BNR repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	Sortilin-Vps10
HKD3_k127_1758346_3	382464.ABSI01000017_gene26	3.042e-250	788.0	COG0674@1|root,COG0674@2|Bacteria,46SM9@74201|Verrucomicrobia,2IV6Q@203494|Verrucomicrobiae	203494|Verrucomicrobiae	C	Pyruvate:ferredoxin oxidoreductase core domain II	-	-	-	-	-	-	-	-	-	-	-	-	PFOR_II,POR,POR_N
HKD3_k127_1758346_35	481448.Minf_0829	3.861e-11	64.0	28I4Y@1|root,2Z88D@2|Bacteria,46VRF@74201|Verrucomicrobia,37GMA@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_1758346_22	478741.JAFS01000001_gene1555	4.024e-69	243.0	28I4Y@1|root,2Z88D@2|Bacteria,46VRF@74201|Verrucomicrobia,37GMA@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_1758346_11	1396418.BATQ01000046_gene6111	1.743e-139	449.0	COG1013@1|root,COG1013@2|Bacteria,46SRY@74201|Verrucomicrobia,2IV9I@203494|Verrucomicrobiae	203494|Verrucomicrobiae	C	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain	-	-	-	-	-	-	-	-	-	-	-	-	TPP_enzyme_C
HKD3_k127_1758346_23	926566.Terro_2310	1.154e-63	228.0	COG0810@1|root,COG0810@2|Bacteria,3Y6JE@57723|Acidobacteria,2JKU7@204432|Acidobacteriia	204432|Acidobacteriia	M	YXWGXW repeat (2 copies)	-	-	-	-	-	-	-	-	-	-	-	-	YXWGXW
HKD3_k127_1769767_5	497964.CfE428DRAFT_4255	2.173e-103	343.0	COG1137@1|root,COG1137@2|Bacteria,46SDI@74201|Verrucomicrobia	74201|Verrucomicrobia	S	PFAM ABC transporter related	-	-	-	ko:K06861	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	1.B.42.1	-	-	ABC_tran
HKD3_k127_1769767_13	497964.CfE428DRAFT_4259	7.174e-17	89.0	2C4M2@1|root,2ZG2A@2|Bacteria,46WV2@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_1769767_3	497964.CfE428DRAFT_4260	1.846e-123	400.0	COG2877@1|root,COG2877@2|Bacteria,46SMZ@74201|Verrucomicrobia	74201|Verrucomicrobia	M	2-dehydro-3-deoxyphosphooctonate aldolase	kdsA	-	2.5.1.55	ko:K01627	ko00540,ko01100,map00540,map01100	M00063	R03254	RC00435	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	DAHP_synth_1
HKD3_k127_1769767_9	497964.CfE428DRAFT_2092	2.708e-36	148.0	COG5522@1|root,COG5522@2|Bacteria,46WTQ@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Integral membrane protein (intg_mem_TP0381)	-	-	-	-	-	-	-	-	-	-	-	-	Intg_mem_TP0381
HKD3_k127_1769767_11	1237149.C900_00956	1.646e-34	145.0	COG0589@1|root,COG0589@2|Bacteria,4NGG8@976|Bacteroidetes,47T99@768503|Cytophagia	976|Bacteroidetes	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD3_k127_1769767_7	497964.CfE428DRAFT_3893	2.626e-68	236.0	COG0669@1|root,COG0669@2|Bacteria,46SUT@74201|Verrucomicrobia	74201|Verrucomicrobia	H	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate	coaD	-	2.7.7.3	ko:K00954	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
HKD3_k127_1769767_10	497964.CfE428DRAFT_3892	4.891e-35	138.0	COG1399@1|root,COG1399@2|Bacteria,46TBP@74201|Verrucomicrobia	74201|Verrucomicrobia	S	metal-binding, possibly nucleic acid-binding protein	-	-	-	ko:K07040	-	-	-	-	ko00000	-	-	-	DUF177
HKD3_k127_1769767_12	497964.CfE428DRAFT_3891	2.363e-21	94.0	COG0333@1|root,COG0333@2|Bacteria,46TCD@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Ribosomal L32p protein family	rpmF	-	-	ko:K02911	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_L32p
HKD3_k127_1769767_4	481448.Minf_1215	3.552e-112	373.0	COG0416@1|root,COG0416@2|Bacteria,46S8C@74201|Verrucomicrobia,37G4Q@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	I	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA	plsX	-	2.3.1.15	ko:K03621	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FA_synthesis
HKD3_k127_1769767_1	497964.CfE428DRAFT_3889	2.33e-148	476.0	COG0332@1|root,COG0332@2|Bacteria,46SE2@74201|Verrucomicrobia	74201|Verrucomicrobia	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	fabH	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
HKD3_k127_1769767_8	485918.Cpin_5156	6.833e-58	207.0	COG4297@1|root,COG4297@2|Bacteria,4NNG0@976|Bacteroidetes,1ISDM@117747|Sphingobacteriia	976|Bacteroidetes	S	Cupin	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_1,Cupin_2
HKD3_k127_1769767_6	883078.HMPREF9695_02286	4.046e-91	307.0	COG2513@1|root,COG2513@2|Bacteria,1R3SD@1224|Proteobacteria,2TRRV@28211|Alphaproteobacteria,3JSI4@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Phosphoenolpyruvate phosphomutase	MA20_35565	-	4.1.3.30	ko:K03417	ko00640,map00640	-	R00409	RC00286,RC00287	ko00000,ko00001,ko01000	-	-	-	PEP_mutase
HKD3_k127_1769767_0	497964.CfE428DRAFT_0737	1.317e-180	580.0	COG0265@1|root,COG0265@2|Bacteria,46UAN@74201|Verrucomicrobia	74201|Verrucomicrobia	O	PFAM peptidase S1 and S6 chymotrypsin Hap	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
HKD3_k127_1769767_2	497964.CfE428DRAFT_0736	1.495e-136	450.0	COG0265@1|root,COG0265@2|Bacteria,46SZ1@74201|Verrucomicrobia	74201|Verrucomicrobia	O	Domain present in PSD-95, Dlg, and ZO-1/2.	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2
HKD3_k127_192558_27	329726.AM1_3792	0.0007209	48.0	COG0515@1|root,COG0515@2|Bacteria,1GA5I@1117|Cyanobacteria	1117|Cyanobacteria	KLT	Domain of unknown function (DUF4189)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4189
HKD3_k127_192558_6	622637.KE124774_gene3597	2.591e-92	333.0	COG0642@1|root,COG2202@1|root,COG2202@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2TWK2@28211|Alphaproteobacteria,3700W@31993|Methylocystaceae	28211|Alphaproteobacteria	T	PAS fold	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg
HKD3_k127_192558_11	1040989.AWZU01000008_gene3672	3.126e-55	200.0	COG4566@1|root,COG4566@2|Bacteria,1R47Z@1224|Proteobacteria,2TSQS@28211|Alphaproteobacteria,3JQPG@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HKD3_k127_192558_18	240016.ABIZ01000001_gene3110	1.856e-26	112.0	COG4566@1|root,COG4566@2|Bacteria,46Z3N@74201|Verrucomicrobia,2IW9Z@203494|Verrucomicrobiae	203494|Verrucomicrobiae	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
HKD3_k127_192558_4	497964.CfE428DRAFT_1380	3.231e-140	454.0	COG3239@1|root,COG3239@2|Bacteria	2|Bacteria	I	unsaturated fatty acid biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	FA_desaturase
HKD3_k127_192558_1	395964.KE386496_gene186	7.426e-221	694.0	COG3119@1|root,COG3119@2|Bacteria,1MUJH@1224|Proteobacteria,2TSB8@28211|Alphaproteobacteria,3NCCR@45404|Beijerinckiaceae	28211|Alphaproteobacteria	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
HKD3_k127_192558_3	1283300.ATXB01000001_gene394	8.955e-161	514.0	COG1262@1|root,COG1262@2|Bacteria,1PHCW@1224|Proteobacteria,1RX5H@1236|Gammaproteobacteria,1XGXI@135618|Methylococcales	135618|Methylococcales	S	Sulfatase-modifying factor enzyme 1	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase
HKD3_k127_192558_19	1122176.KB903587_gene4547	1.515e-25	109.0	2DNGD@1|root,32XCZ@2|Bacteria,4NSM2@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_192558_21	886293.Sinac_2776	2.502e-24	106.0	COG0560@1|root,COG0560@2|Bacteria,2IXZ0@203682|Planctomycetes	203682|Planctomycetes	E	haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD
HKD3_k127_192558_12	1485545.JQLW01000010_gene1615	8.226e-52	201.0	COG0642@1|root,COG3829@1|root,COG2205@2|Bacteria,COG3829@2|Bacteria,1NRP8@1224|Proteobacteria	1224|Proteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HATPase_c,HisKA,Hpt,PAS_3,PAS_4,PAS_9,PocR,Response_reg,SBP_bac_3
HKD3_k127_192558_14	95619.PM1_0223610	4.474e-46	173.0	COG2928@1|root,COG2928@2|Bacteria,1NF4R@1224|Proteobacteria,1SFUD@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Conserved Protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF502
HKD3_k127_192558_2	1341181.FLJC2902T_28560	4.027e-180	571.0	COG3119@1|root,COG3119@2|Bacteria,4NFRB@976|Bacteroidetes,1HX8I@117743|Flavobacteriia,2NTFM@237|Flavobacterium	976|Bacteroidetes	P	Arylsulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase,Sulfatase_C
HKD3_k127_192558_24	402626.Rpic_3996	1.797e-10	69.0	2E9SI@1|root,333YQ@2|Bacteria,1RI7T@1224|Proteobacteria,2VXBI@28216|Betaproteobacteria,1KHJN@119060|Burkholderiaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	PsiF_repeat
HKD3_k127_192558_20	338969.Rfer_2429	1.873e-24	108.0	COG3753@1|root,COG3753@2|Bacteria,1N7FF@1224|Proteobacteria,2VVTK@28216|Betaproteobacteria,4AFP9@80864|Comamonadaceae	28216|Betaproteobacteria	S	Bacterial protein of unknown function (DUF937)	-	-	-	-	-	-	-	-	-	-	-	-	DUF937
HKD3_k127_192558_0	1267533.KB906735_gene4441	2.427e-317	975.0	COG3119@1|root,COG3119@2|Bacteria	2|Bacteria	P	arylsulfatase activity	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase,Sulfatase_C
HKD3_k127_192558_26	1169143.KB911035_gene2314	2.301e-05	53.0	COG2067@1|root,COG2067@2|Bacteria,1RJIQ@1224|Proteobacteria,2WFUS@28216|Betaproteobacteria	28216|Betaproteobacteria	I	long-chain fatty acid transport protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_192558_10	768671.ThimaDRAFT_2120	3.641e-70	241.0	29C7G@1|root,3163F@2|Bacteria,1QDGP@1224|Proteobacteria,1TKCK@1236|Gammaproteobacteria,1X1VP@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_192558_17	497964.CfE428DRAFT_3484	9.749e-31	123.0	COG2261@1|root,COG2261@2|Bacteria	2|Bacteria	S	Transglycosylase associated protein	-	-	-	-	-	-	-	-	-	-	-	-	Transgly_assoc
HKD3_k127_192558_9	478741.JAFS01000002_gene274	1.899e-75	259.0	COG0580@1|root,COG0580@2|Bacteria,46V4E@74201|Verrucomicrobia,37GHA@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	G	Major intrinsic protein	glpF	-	-	ko:K06188	-	-	-	-	ko00000,ko02000	1.A.8	-	-	MIP
HKD3_k127_192558_8	497964.CfE428DRAFT_1833	7.249e-78	282.0	COG1075@1|root,COG1075@2|Bacteria,46TIU@74201|Verrucomicrobia	74201|Verrucomicrobia	S	acetyltransferases and hydrolases with the alpha beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
HKD3_k127_192558_13	521674.Plim_2411	3.326e-48	181.0	COG1226@1|root,32Y28@2|Bacteria,2J0V4@203682|Planctomycetes	203682|Planctomycetes	P	Ion channel	-	-	-	-	-	-	-	-	-	-	-	-	Ion_trans_2
HKD3_k127_192558_5	706587.Desti_3024	1.846e-122	401.0	COG0604@1|root,COG0604@2|Bacteria,1MX8A@1224|Proteobacteria,43DPM@68525|delta/epsilon subdivisions,2X9UC@28221|Deltaproteobacteria,2MS8D@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Zinc-binding dehydrogenase	-	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
HKD3_k127_192558_15	1161401.ASJA01000003_gene2770	2.977e-44	168.0	COG3409@1|root,COG3409@2|Bacteria,1NP3I@1224|Proteobacteria,2UM8V@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Peptidoglycan-binding domain 1 protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_1951936_8	278957.ABEA03000176_gene2789	3.54e-68	242.0	COG1009@1|root,COG1009@2|Bacteria,46SDU@74201|Verrucomicrobia,3K8RK@414999|Opitutae	414999|Opitutae	CP	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus	-	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M,Proton_antipo_N
HKD3_k127_1951936_4	1267534.KB906754_gene3772	7.798e-147	481.0	COG1008@1|root,COG1008@2|Bacteria,3Y6ZF@57723|Acidobacteria,2JMB1@204432|Acidobacteriia	204432|Acidobacteriia	C	Proton-conducting membrane transporter	-	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
HKD3_k127_1951936_3	1267534.KB906754_gene3771	2.722e-159	519.0	COG1008@1|root,COG1008@2|Bacteria,3Y6FA@57723|Acidobacteria,2JM6J@204432|Acidobacteriia	204432|Acidobacteriia	C	Proton-conducting membrane transporter	-	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
HKD3_k127_1951936_5	1267534.KB906754_gene3770	5.905e-128	425.0	COG1007@1|root,COG1007@2|Bacteria,3Y73U@57723|Acidobacteria,2JMM8@204432|Acidobacteriia	204432|Acidobacteriia	C	Proton-conducting membrane transporter	-	-	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
HKD3_k127_1951936_2	1521187.JPIM01000056_gene2609	1.005e-164	523.0	COG1899@1|root,COG1899@2|Bacteria,2G7R7@200795|Chloroflexi,374VZ@32061|Chloroflexia	32061|Chloroflexia	O	PFAM deoxyhypusine synthase	-	-	2.5.1.46	ko:K00809	-	-	-	-	ko00000,ko01000	-	-	-	DS
HKD3_k127_1951936_6	497964.CfE428DRAFT_3830	1.946e-93	310.0	COG0313@1|root,COG0313@2|Bacteria,46SVC@74201|Verrucomicrobia	74201|Verrucomicrobia	H	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA	rsmI	-	2.1.1.198	ko:K07056	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TP_methylase
HKD3_k127_1951936_7	251229.Chro_5241	4.075e-77	274.0	COG5542@1|root,COG5542@2|Bacteria,1G4VD@1117|Cyanobacteria	1117|Cyanobacteria	S	integral membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_1951936_0	497964.CfE428DRAFT_4183	1.636e-226	711.0	COG1232@1|root,COG1232@2|Bacteria,46TGR@74201|Verrucomicrobia	74201|Verrucomicrobia	H	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
HKD3_k127_1951936_1	28072.Nos7524_0944	8.549e-208	653.0	COG0403@1|root,COG1003@1|root,COG0403@2|Bacteria,COG1003@2|Bacteria,1G1HW@1117|Cyanobacteria,1HJRQ@1161|Nostocales	1117|Cyanobacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvP	-	1.4.4.2	ko:K00281	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko00002,ko01000	-	-	-	GDC-P
HKD3_k127_1982455_0	1396141.BATP01000059_gene2438	1.016e-232	729.0	COG0469@1|root,COG0469@2|Bacteria,46SBJ@74201|Verrucomicrobia,2ITNV@203494|Verrucomicrobiae	2|Bacteria	G	Pyruvate kinase, barrel domain	pyk	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PK,PK_C
HKD3_k127_1982455_1	452637.Oter_0554	2.865e-196	621.0	COG1236@1|root,COG1236@2|Bacteria,46UFS@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Beta-Casp domain	-	-	-	ko:K07576	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B,Lactamase_B_6,RMMBL
HKD3_k127_1982455_2	497964.CfE428DRAFT_1140	1.212e-115	377.0	COG1611@1|root,COG1611@2|Bacteria,46SEG@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Possible lysine decarboxylase	-	-	-	-	-	-	-	-	-	-	-	-	Lysine_decarbox
HKD3_k127_1982455_4	177437.HRM2_38050	1.699e-10	62.0	COG0205@1|root,COG0205@2|Bacteria,1MVN3@1224|Proteobacteria,42Q5V@68525|delta/epsilon subdivisions,2WJA1@28221|Deltaproteobacteria,2MJ9S@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis	pfk-1	-	2.7.1.11,2.7.1.90	ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
HKD3_k127_1995257_1	933262.AXAM01000047_gene2343	6.757e-177	566.0	COG2252@1|root,COG2252@2|Bacteria,1MUV0@1224|Proteobacteria,42MAE@68525|delta/epsilon subdivisions,2WKFF@28221|Deltaproteobacteria,2MKCJ@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Permease family	pbuG	-	-	ko:K06901	-	-	-	-	ko00000,ko02000	2.A.1.40	-	-	Xan_ur_permease
HKD3_k127_1995257_4	686340.Metal_0729	2.306e-40	151.0	2C82G@1|root,32RK9@2|Bacteria,1MZV5@1224|Proteobacteria,1SAWR@1236|Gammaproteobacteria,1XFGD@135618|Methylococcales	135618|Methylococcales	S	Protein of unknown function (DUF4242)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4242
HKD3_k127_1995257_2	497964.CfE428DRAFT_0924	1.16e-108	366.0	COG0795@1|root,COG0795@2|Bacteria,46STR@74201|Verrucomicrobia	74201|Verrucomicrobia	S	PFAM permease YjgP YjgQ family protein	-	-	-	ko:K07091	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko02000	1.B.42.1	-	-	YjgP_YjgQ
HKD3_k127_1995257_0	243233.MCA0472	5.72e-219	697.0	COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,1RQ7D@1236|Gammaproteobacteria,1XDVZ@135618|Methylococcales	135618|Methylococcales	F	PFAM Asparagine synthase	-	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
HKD3_k127_1995257_3	1156937.MFUM_1010020	2.57e-46	181.0	COG1807@1|root,COG1807@2|Bacteria,46SSE@74201|Verrucomicrobia,37FZY@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PAP2,PMT_2,TPR_12
HKD3_k127_2219276_9	671143.DAMO_2857	9.415e-55	217.0	COG0823@1|root,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40
HKD3_k127_2219276_12	1123508.JH636447_gene7857	1.862e-26	122.0	COG2931@1|root,COG3291@1|root,COG2931@2|Bacteria,COG3291@2|Bacteria,2IZ0P@203682|Planctomycetes	203682|Planctomycetes	Q	Haemolysin-type calcium-binding repeat (2 copies)	-	-	-	-	-	-	-	-	-	-	-	-	HemolysinCabind,Laminin_G_3
HKD3_k127_2219276_3	269797.Mbar_A3461	7.797e-158	522.0	COG3291@1|root,COG3391@1|root,arCOG02516@1|root,arCOG02550@1|root,arCOG03991@1|root,arCOG02508@2157|Archaea,arCOG02516@2157|Archaea,arCOG02550@2157|Archaea,arCOG02562@2157|Archaea,arCOG03991@2157|Archaea,2XUY6@28890|Euryarchaeota,2NAFS@224756|Methanomicrobia	224756|Methanomicrobia	O	PFAM PKD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	PKD
HKD3_k127_2219276_10	502025.Hoch_1576	6.131e-53	195.0	COG1595@1|root,COG1595@2|Bacteria,1RINW@1224|Proteobacteria,4385N@68525|delta/epsilon subdivisions,2X3FI@28221|Deltaproteobacteria,2YVVV@29|Myxococcales	28221|Deltaproteobacteria	K	ECF sigma factor	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_ECF
HKD3_k127_2219276_4	1183438.GKIL_2770	3.936e-152	516.0	COG0457@1|root,COG0515@1|root,COG5616@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG5616@2|Bacteria,1G1EB@1117|Cyanobacteria	1117|Cyanobacteria	KLT	serine threonine protein kinase	-	-	2.7.1.37,2.7.11.1	ko:K00870,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	FHA,Pkinase,TPR_11,TPR_16,TPR_8
HKD3_k127_2219276_1	468059.AUHA01000002_gene43	2.44e-206	664.0	COG3186@1|root,COG3186@2|Bacteria,4NEX5@976|Bacteroidetes,1IQDN@117747|Sphingobacteriia	976|Bacteroidetes	E	Biopterin-dependent aromatic amino acid hydroxylase	phhA	-	1.14.16.1	ko:K00500	ko00360,ko00400,ko00790,ko01100,ko01230,map00360,map00400,map00790,map01100,map01230	-	R01795,R07211	RC00490	ko00000,ko00001,ko01000	-	-	-	Biopterin_H
HKD3_k127_2219276_15	502025.Hoch_3106	1.033e-15	91.0	COG1196@1|root,COG1196@2|Bacteria,1NDEE@1224|Proteobacteria,432MG@68525|delta/epsilon subdivisions,2WX8S@28221|Deltaproteobacteria,2Z20N@29|Myxococcales	28221|Deltaproteobacteria	D	Domain of unknown function (DUF4349)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4349
HKD3_k127_2219276_14	288705.RSal33209_0464	9.833e-19	93.0	COG1595@1|root,COG1595@2|Bacteria,2GJMX@201174|Actinobacteria,1WA3Q@1268|Micrococcaceae	201174|Actinobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD3_k127_2219276_7	1403819.BATR01000021_gene754	1.976e-95	323.0	COG1376@1|root,COG1376@2|Bacteria,46UGX@74201|Verrucomicrobia,2IV70@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	L,D-transpeptidase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_1,YkuD
HKD3_k127_2219276_6	1301098.PKB_2297	3.831e-97	325.0	COG0500@1|root,COG2226@2|Bacteria,1MXP4@1224|Proteobacteria,1RRP4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	Methyl-transferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
HKD3_k127_2219276_0	644968.DFW101_2128	1.586e-225	716.0	COG0296@1|root,COG0296@2|Bacteria,1MVM7@1224|Proteobacteria,42MKI@68525|delta/epsilon subdivisions,2WM5H@28221|Deltaproteobacteria,2MEEN@213115|Desulfovibrionales	28221|Deltaproteobacteria	G	Domain of unknown function (DUF3459)	treZ-2	-	3.2.1.141	ko:K01236	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11256	RC00049	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48,DUF3459
HKD3_k127_2219276_16	1288484.APCS01000080_gene2122	8.905e-10	65.0	COG1670@1|root,COG1670@2|Bacteria,1WKC5@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	J	COGs COG1670 Acetyltransferase including N-acetylase of ribosomal protein	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
HKD3_k127_2219276_5	1192034.CAP_6066	7.485e-100	339.0	COG0604@1|root,COG0604@2|Bacteria,1MX8A@1224|Proteobacteria	1224|Proteobacteria	C	COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases	-	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N_2
HKD3_k127_2219276_17	1123073.KB899243_gene504	8.147e-08	61.0	2AEZN@1|root,314XR@2|Bacteria,1NSHG@1224|Proteobacteria,1SMR4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_2219276_2	497964.CfE428DRAFT_4128	4.546e-171	545.0	COG0045@1|root,COG0045@2|Bacteria,46TDG@74201|Verrucomicrobia	74201|Verrucomicrobia	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit	sucC	-	6.2.1.5	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,Ligase_CoA
HKD3_k127_2219276_13	237368.SCABRO_00846	3.114e-20	104.0	2CCSR@1|root,32RWC@2|Bacteria,2J1M5@203682|Planctomycetes	203682|Planctomycetes	S	23S rRNA-intervening sequence protein	-	-	-	-	-	-	-	-	-	-	-	-	23S_rRNA_IVP
HKD3_k127_2219276_8	1121904.ARBP01000011_gene1543	1.794e-60	225.0	COG1073@1|root,COG1073@2|Bacteria,4P9E8@976|Bacteroidetes,47R3G@768503|Cytophagia	976|Bacteroidetes	O	Domain present in PSD-95, Dlg, and ZO-1/2.	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4,PDZ_2
HKD3_k127_2392843_6	344747.PM8797T_25221	9.58e-08	58.0	2E4JC@1|root,32ZEE@2|Bacteria,2J0SF@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_2392843_0	1499967.BAYZ01000139_gene157	1.606e-255	812.0	COG0466@1|root,COG0466@2|Bacteria,2NNNN@2323|unclassified Bacteria	2|Bacteria	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
HKD3_k127_2392843_4	1396418.BATQ01000055_gene267	5.612e-22	100.0	COG0071@1|root,COG0071@2|Bacteria	2|Bacteria	O	Belongs to the small heat shock protein (HSP20) family	MA20_45160	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
HKD3_k127_2392843_1	215803.DB30_4063	4.382e-220	696.0	COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,42PGV@68525|delta/epsilon subdivisions,2WIS0@28221|Deltaproteobacteria,2YZVC@29|Myxococcales	28221|Deltaproteobacteria	Q	Amidohydrolase family	-	-	3.5.1.81	ko:K06015	-	-	R02192	RC00064,RC00328	ko00000,ko01000	-	-	-	Amidohydro_3
HKD3_k127_2392843_3	1203550.HMPREF1475_01227	1.524e-35	144.0	2E2TX@1|root,32XW1@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_2392843_2	1123073.KB899245_gene90	1.609e-69	240.0	COG2021@1|root,COG2021@2|Bacteria,1MVJV@1224|Proteobacteria,1RQ2N@1236|Gammaproteobacteria,1X88E@135614|Xanthomonadales	135614|Xanthomonadales	E	alpha/beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
HKD3_k127_2414627_1	240015.ACP_2101	9.04e-69	243.0	2E27Y@1|root,32XE5@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF3419
HKD3_k127_2414627_2	240015.ACP_2102	3.028e-32	130.0	2EUF0@1|root,33MXB@2|Bacteria	2|Bacteria	S	DoxX-like family	-	-	-	-	-	-	-	-	-	-	-	-	DoxX_3
HKD3_k127_2414627_0	489825.LYNGBM3L_01940	1.039e-137	444.0	COG1052@1|root,COG1052@2|Bacteria,1G028@1117|Cyanobacteria,1H7XD@1150|Oscillatoriales	1117|Cyanobacteria	CH	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain	ddh	-	1.1.1.28	ko:K03778	ko00620,ko01120,map00620,map01120	-	R00704	RC00044	ko00000,ko00001,ko01000	-	-	-	2-Hacid_dh,2-Hacid_dh_C
HKD3_k127_2419576_2	266117.Rxyl_0485	2.751e-98	326.0	COG1235@1|root,COG1235@2|Bacteria	2|Bacteria	P	May be involved in the transport of PQQ or its precursor to the periplasm	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
HKD3_k127_2419576_5	33876.JNXY01000014_gene3979	1.972e-39	154.0	COG1504@1|root,COG1504@2|Bacteria,2IRTB@201174|Actinobacteria,4DE4J@85008|Micromonosporales	201174|Actinobacteria	S	Protein of unknown function (DUF498/DUF598)	-	-	-	-	-	-	-	-	-	-	-	-	DUF498
HKD3_k127_2419576_7	526227.Mesil_1441	4.215e-12	73.0	COG0365@1|root,COG0365@2|Bacteria,1WIHG@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	I	AMP-dependent synthetase and ligase	-	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
HKD3_k127_2419576_1	370438.PTH_2316	6.726e-116	387.0	COG2271@1|root,COG2271@2|Bacteria,1TS8X@1239|Firmicutes,24A85@186801|Clostridia,2646A@186807|Peptococcaceae	186801|Clostridia	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD3_k127_2419576_0	1234364.AMSF01000055_gene1087	9.558e-234	730.0	COG1788@1|root,COG2057@1|root,COG1788@2|Bacteria,COG2057@2|Bacteria,1MVEI@1224|Proteobacteria,1RNXB@1236|Gammaproteobacteria,1X3W4@135614|Xanthomonadales	135614|Xanthomonadales	I	transferase	-	-	2.8.3.5	ko:K01027	ko00072,ko00280,ko00650,map00072,map00280,map00650	-	R00410	RC00014	ko00000,ko00001,ko01000	-	-	-	CoA_trans
HKD3_k127_2419576_3	1163409.UUA_13255	7.264e-64	223.0	COG5483@1|root,COG5483@2|Bacteria,1RDGV@1224|Proteobacteria,1S5VD@1236|Gammaproteobacteria,1XBWX@135614|Xanthomonadales	135614|Xanthomonadales	S	Protein of unknown function, DUF488	-	-	-	-	-	-	-	-	-	-	-	-	DUF488
HKD3_k127_2419576_4	497964.CfE428DRAFT_0145	1.192e-52	189.0	COG4826@1|root,COG4826@2|Bacteria,46VTK@74201|Verrucomicrobia	74201|Verrucomicrobia	O	SERine  Proteinase INhibitors	-	-	-	-	-	-	-	-	-	-	-	-	Serpin
HKD3_k127_2482875_0	1183438.GKIL_0413	1.851e-42	170.0	COG2911@1|root,COG5295@1|root,COG2911@2|Bacteria,COG5295@2|Bacteria	2|Bacteria	UW	Hep Hag repeat protein	-	GO:0005575,GO:0005576	-	-	-	-	-	-	-	-	-	-	CBM_3,CHAT,CHU_C,Cohesin,Peptidase_S74
HKD3_k127_2482875_2	1137281.D778_01482	2.146e-14	85.0	COG3209@1|root,COG5295@1|root,COG3209@2|Bacteria,COG5295@2|Bacteria,4NJTK@976|Bacteroidetes,1HZNB@117743|Flavobacteriia	976|Bacteroidetes	UW	surface antigen	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S74
HKD3_k127_2486948_3	335543.Sfum_3099	8.557e-16	78.0	2E69N@1|root,330XJ@2|Bacteria,1NM8X@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_2486948_1	497964.CfE428DRAFT_0883	1.179e-61	216.0	COG0537@1|root,COG0537@2|Bacteria,46T23@74201|Verrucomicrobia	74201|Verrucomicrobia	FG	PFAM histidine triad (HIT) protein	-	-	2.7.7.53	ko:K19710	ko00230,map00230	-	R00126,R01618	RC00002,RC02753,RC02795	ko00000,ko00001,ko01000	-	-	-	HIT
HKD3_k127_2486948_5	243090.RB7149	6.203e-08	62.0	COG3468@1|root,COG3468@2|Bacteria,2J1BR@203682|Planctomycetes	203682|Planctomycetes	MU	outer membrane autotransporter barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_2486948_0	497964.CfE428DRAFT_5482	2.795e-88	312.0	2FEQM@1|root,346PU@2|Bacteria,46W7F@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_2486948_4	761193.Runsl_5601	1.711e-08	55.0	COG0316@1|root,COG0316@2|Bacteria,4NQC8@976|Bacteroidetes,47QAX@768503|Cytophagia	976|Bacteroidetes	S	Belongs to the HesB IscA family	iscA	-	-	ko:K13628	-	-	-	-	ko00000,ko03016	-	-	-	Fe-S_biosyn
HKD3_k127_2517179_10	240016.ABIZ01000001_gene49	2.689e-15	76.0	COG1236@1|root,COG1793@1|root,COG1236@2|Bacteria,COG1793@2|Bacteria,46SCR@74201|Verrucomicrobia,2ITPW@203494|Verrucomicrobiae	203494|Verrucomicrobiae	JL	DNA ligase N terminus	-	-	-	-	-	-	-	-	-	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,DNA_ligase_A_N,RMMBL
HKD3_k127_2517179_3	497964.CfE428DRAFT_0887	1.488e-72	249.0	COG0204@1|root,COG0204@2|Bacteria,46SYR@74201|Verrucomicrobia	74201|Verrucomicrobia	I	PFAM phospholipid glycerol acyltransferase	-	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
HKD3_k127_2517179_4	497964.CfE428DRAFT_0888	6.572e-64	226.0	COG0283@1|root,COG0283@2|Bacteria	2|Bacteria	F	belongs to the cytidylate kinase family. Type 1 subfamily	cmk	GO:0003674,GO:0003824,GO:0004127,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006573,GO:0006575,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009165,GO:0009314,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0015939,GO:0015940,GO:0015949,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0034654,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046939,GO:0046940,GO:0050145,GO:0050896,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	1.17.7.4,2.5.1.19,2.7.1.26,2.7.4.25,2.7.7.2,6.3.2.1	ko:K00800,ko:K00945,ko:K02945,ko:K03527,ko:K03977,ko:K11753,ko:K13799	ko00240,ko00400,ko00410,ko00740,ko00770,ko00900,ko01100,ko01110,ko01130,ko01230,ko03010,map00240,map00400,map00410,map00740,map00770,map00900,map01100,map01110,map01130,map01230,map03010	M00022,M00052,M00096,M00119,M00125,M00178	R00158,R00161,R00512,R00549,R01665,R02473,R03460,R05884,R08210	RC00002,RC00017,RC00096,RC00141,RC00350,RC01137,RC01487	br01610,ko00000,ko00001,ko00002,ko01000,ko03009,ko03011	-	-	iPC815.YPO1391,iSDY_1059.SDY_2348	Cytidylate_kin
HKD3_k127_2517179_1	497964.CfE428DRAFT_0889	2.493e-171	548.0	COG0128@1|root,COG0128@2|Bacteria,46SFD@74201|Verrucomicrobia	74201|Verrucomicrobia	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	-	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytidylate_kin,EPSP_synthase
HKD3_k127_2517179_11	497964.CfE428DRAFT_0891	1.501e-14	79.0	2DBSP@1|root,2ZAT9@2|Bacteria,46TYZ@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_2517179_2	497964.CfE428DRAFT_2381	1.541e-90	312.0	COG2208@1|root,COG3437@1|root,COG2208@2|Bacteria,COG3437@2|Bacteria	2|Bacteria	T	response regulator, receiver	-	-	3.1.3.3	ko:K07315,ko:K20977	ko02020,ko02025,map02020,map02025	M00820	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko03021	-	-	-	HATPase_c,HATPase_c_2,HisKA,Response_reg,SpoIIE
HKD3_k127_2517179_8	278957.ABEA03000195_gene469	2.202e-31	124.0	COG5531@1|root,COG5531@2|Bacteria,46T1X@74201|Verrucomicrobia,3K8F3@414999|Opitutae	414999|Opitutae	B	SWI complex, BAF60b domains	-	-	-	-	-	-	-	-	-	-	-	-	SWIB
HKD3_k127_2517179_6	481448.Minf_0355	7.686e-42	159.0	COG0526@1|root,COG0526@2|Bacteria,46SXQ@74201|Verrucomicrobia,37GRV@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	CO	Protein of unknown function, DUF255	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_2,Thioredoxin_7
HKD3_k127_2517179_9	497964.CfE428DRAFT_2283	9.519e-31	126.0	COG2331@1|root,COG2331@2|Bacteria,46T2S@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Putative regulatory protein	-	-	-	-	-	-	-	-	-	-	-	-	Zn-ribbon_8
HKD3_k127_2517179_7	1408473.JHXO01000012_gene336	7.143e-37	146.0	COG1418@1|root,COG1418@2|Bacteria	2|Bacteria	S	mRNA catabolic process	-	-	-	ko:K06950,ko:K09163	-	-	-	-	ko00000	-	-	-	HD
HKD3_k127_2517179_0	945713.IALB_1150	1.386e-234	742.0	COG0065@1|root,COG0066@1|root,COG0065@2|Bacteria,COG0066@2|Bacteria	2|Bacteria	E	3-isopropylmalate dehydratase activity	leuD	-	4.2.1.33,4.2.1.35,4.2.1.36	ko:K01703,ko:K01704,ko:K01705	ko00290,ko00300,ko00660,ko00966,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00290,map00300,map00660,map00966,map01100,map01110,map01120,map01130,map01210,map01230	M00030,M00432,M00433,M00535	R03896,R03898,R03968,R04001,R04371,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00618,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
HKD3_k127_2517179_5	1047013.AQSP01000140_gene2452	3.099e-46	169.0	COG0473@1|root,COG0473@2|Bacteria,2NNUM@2323|unclassified Bacteria	2|Bacteria	CE	Isocitrate/isopropylmalate dehydrogenase	dlpA	-	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh,MoCF_biosynth,RraA-like
HKD3_k127_2517753_8	1123242.JH636435_gene2613	1.114e-35	142.0	COG1595@1|root,COG1595@2|Bacteria,2IZZP@203682|Planctomycetes	203682|Planctomycetes	K	Sigma-70 region 2	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2
HKD3_k127_2517753_5	234267.Acid_7916	4.205e-124	434.0	COG0457@1|root,COG0515@1|root,COG5616@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG5616@2|Bacteria	234267.Acid_7916|-	S	cAMP biosynthetic process	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	-
HKD3_k127_2517753_6	1121937.AUHJ01000010_gene1639	1.036e-81	305.0	COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,1MU9K@1224|Proteobacteria,1RMTG@1236|Gammaproteobacteria,4651V@72275|Alteromonadaceae	1236|Gammaproteobacteria	P	COG1629 Outer membrane receptor proteins, mostly Fe transport	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
HKD3_k127_2517753_12	1267535.KB906767_gene5189	1.766e-09	68.0	COG0457@1|root,COG0457@2|Bacteria,3Y3BD@57723|Acidobacteria	57723|Acidobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TPR_11,TPR_16,TPR_2,TPR_8
HKD3_k127_2517753_10	794903.OPIT5_10435	2.737e-27	120.0	2EHW5@1|root,33BMQ@2|Bacteria,46WAC@74201|Verrucomicrobia,3K9R0@414999|Opitutae	414999|Opitutae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_2517753_1	481448.Minf_1075	1.913e-185	591.0	COG0004@1|root,COG0004@2|Bacteria,46SCE@74201|Verrucomicrobia,37FY5@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	P	Ammonium Transporter Family	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
HKD3_k127_2517753_13	1147.D082_08720	6.457e-08	64.0	COG0265@1|root,COG0265@2|Bacteria,1G0U4@1117|Cyanobacteria,1H56E@1142|Synechocystis	1117|Cyanobacteria	O	Trypsin	htrA	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
HKD3_k127_2517753_14	452637.Oter_1653	1.487e-06	57.0	2C12Z@1|root,2ZUMU@2|Bacteria,46WS3@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_2517753_9	497964.CfE428DRAFT_0192	2.816e-34	139.0	COG1595@1|root,COG1595@2|Bacteria,46WAM@74201|Verrucomicrobia	74201|Verrucomicrobia	K	TIGRFAM RNA polymerase sigma factor, sigma-70 family	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
HKD3_k127_2517753_3	497964.CfE428DRAFT_3886	2.09e-131	430.0	COG4124@1|root,COG4124@2|Bacteria	2|Bacteria	G	Belongs to the glycosyl hydrolase 26 family	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_26
HKD3_k127_2517753_11	1396141.BATP01000016_gene2783	3.097e-11	72.0	2BN1X@1|root,32GN2@2|Bacteria,46XN3@74201|Verrucomicrobia,2IW8A@203494|Verrucomicrobiae	203494|Verrucomicrobiae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_2517753_0	1304885.AUEY01000078_gene1047	8.869e-201	649.0	COG3664@1|root,COG3664@2|Bacteria,1NSK2@1224|Proteobacteria	1224|Proteobacteria	G	F5/8 type C domain	-	-	-	-	-	-	-	-	-	-	-	-	F5_F8_type_C
HKD3_k127_2517753_4	1396418.BATQ01000046_gene6165	9.461e-128	418.0	COG2805@1|root,COG2805@2|Bacteria,46XD7@74201|Verrucomicrobia,2IVHZ@203494|Verrucomicrobiae	203494|Verrucomicrobiae	NU	Type II/IV secretion system protein	-	-	-	-	-	-	-	-	-	-	-	-	T2SSE
HKD3_k127_2517753_2	1403819.BATR01000181_gene6180	1.285e-143	463.0	COG2805@1|root,COG2805@2|Bacteria,46ZKR@74201|Verrucomicrobia,2IVJW@203494|Verrucomicrobiae	203494|Verrucomicrobiae	NU	Type II/IV secretion system protein	-	-	-	-	-	-	-	-	-	-	-	-	T2SSE
HKD3_k127_2517753_7	1267533.KB906741_gene641	6.201e-41	157.0	COG4319@1|root,COG4319@2|Bacteria,3Y5EF@57723|Acidobacteria,2JJP7@204432|Acidobacteriia	204432|Acidobacteriia	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440
HKD3_k127_2524036_7	1403819.BATR01000027_gene885	3.817e-83	284.0	COG1505@1|root,COG1505@2|Bacteria,46TIX@74201|Verrucomicrobia	74201|Verrucomicrobia	E	Prolyl oligopeptidase, N-terminal beta-propeller domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S9,Peptidase_S9_N
HKD3_k127_2524036_12	497964.CfE428DRAFT_1503	2.937e-58	210.0	COG2867@1|root,COG2867@2|Bacteria	2|Bacteria	I	negative regulation of translational initiation	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc,Polyketide_cyc2,START
HKD3_k127_2524036_1	497964.CfE428DRAFT_3287	4.813e-188	598.0	COG2204@1|root,COG2204@2|Bacteria,46SFE@74201|Verrucomicrobia	74201|Verrucomicrobia	T	Two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD3_k127_2524036_0	497964.CfE428DRAFT_3032	3.811e-222	698.0	COG1109@1|root,COG1109@2|Bacteria,46SJ2@74201|Verrucomicrobia	74201|Verrucomicrobia	G	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate	glmM	-	5.4.2.10	ko:K03431	ko00520,ko01100,ko01130,map00520,map01100,map01130	-	R02060	RC00408	ko00000,ko00001,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
HKD3_k127_2524036_13	240016.ABIZ01000001_gene1756	5.379e-57	206.0	COG1386@1|root,COG1386@2|Bacteria,46VRU@74201|Verrucomicrobia,2IUTS@203494|Verrucomicrobiae	203494|Verrucomicrobiae	K	Segregation and condensation complex subunit ScpB	-	-	-	-	-	-	-	-	-	-	-	-	SMC_ScpB
HKD3_k127_2524036_6	1156937.MFUM_250004	3.215e-89	306.0	COG1680@1|root,COG1680@2|Bacteria,46UDJ@74201|Verrucomicrobia,37GHB@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	V	Beta-lactamase	ampC	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
HKD3_k127_2524036_18	1123073.KB899244_gene352	7.473e-11	69.0	COG4319@1|root,COG4319@2|Bacteria,1QDB7@1224|Proteobacteria,1T990@1236|Gammaproteobacteria,1XBUD@135614|Xanthomonadales	135614|Xanthomonadales	S	Domain of unknown function (DUF4440)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440
HKD3_k127_2524036_9	452637.Oter_0012	2.372e-66	232.0	COG1704@1|root,COG1704@2|Bacteria,46V9M@74201|Verrucomicrobia,3K7DK@414999|Opitutae	2|Bacteria	S	PFAM LemA family protein	lemA	-	-	ko:K03744	-	-	-	-	ko00000	-	-	-	LemA
HKD3_k127_2524036_11	452637.Oter_0011	2.912e-60	221.0	COG1512@1|root,COG1512@2|Bacteria,46T36@74201|Verrucomicrobia	74201|Verrucomicrobia	S	TPM domain	-	-	-	ko:K06872	-	-	-	-	ko00000	-	-	-	TPM_phosphatase
HKD3_k127_2524036_16	497964.CfE428DRAFT_4724	1.807e-37	148.0	COG3762@1|root,COG3762@2|Bacteria,46T8V@74201|Verrucomicrobia	74201|Verrucomicrobia	S	TPM domain	-	-	-	-	-	-	-	-	-	-	-	-	TPM_phosphatase
HKD3_k127_2524036_3	240016.ABIZ01000001_gene1994	8.164e-152	486.0	COG0202@1|root,COG0202@2|Bacteria,46S52@74201|Verrucomicrobia,2ITN6@203494|Verrucomicrobiae	203494|Verrucomicrobiae	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA	-	2.7.7.6	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L
HKD3_k127_2524036_14	1123070.KB899251_gene717	3.611e-41	159.0	COG0203@1|root,COG0203@2|Bacteria,46TC9@74201|Verrucomicrobia,2IUE5@203494|Verrucomicrobiae	203494|Verrucomicrobiae	J	Ribosomal protein L17	rplQ	-	-	ko:K02879	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L17
HKD3_k127_2524036_15	278957.ABEA03000176_gene2798	2.971e-39	149.0	COG0838@1|root,COG0838@2|Bacteria,46XVA@74201|Verrucomicrobia,3K8I9@414999|Opitutae	414999|Opitutae	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain	-	-	1.6.5.3	ko:K00330	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q4
HKD3_k127_2524036_4	1267534.KB906754_gene3780	2.256e-95	316.0	COG0377@1|root,COG0377@2|Bacteria,3Y74G@57723|Acidobacteria,2JKT1@204432|Acidobacteriia	204432|Acidobacteriia	C	NADH ubiquinone oxidoreductase, 20 Kd subunit	-	-	1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q6
HKD3_k127_2524036_5	1267534.KB906754_gene3779	7.084e-91	303.0	COG0852@1|root,COG0852@2|Bacteria,3Y72R@57723|Acidobacteria,2JM53@204432|Acidobacteriia	204432|Acidobacteriia	C	Respiratory-chain NADH dehydrogenase, 30 Kd subunit	-	-	1.6.5.3	ko:K00332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa
HKD3_k127_2524036_2	240015.ACP_2568	2.21e-183	580.0	COG0649@1|root,COG0649@2|Bacteria,3Y6MU@57723|Acidobacteria,2JKN7@204432|Acidobacteriia	204432|Acidobacteriia	C	Respiratory-chain NADH dehydrogenase, 49 Kd subunit	-	-	1.6.5.3	ko:K00333	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa
HKD3_k127_2524036_8	240015.ACP_2569	1.131e-74	256.0	COG1143@1|root,COG1143@2|Bacteria,3Y6N6@57723|Acidobacteria,2JKQS@204432|Acidobacteriia	204432|Acidobacteriia	C	4Fe-4S dicluster domain	-	-	1.6.5.3	ko:K00338	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer4_7
HKD3_k127_2524036_19	1396418.BATQ01000110_gene4764	1.308e-06	57.0	2BTYD@1|root,32P6T@2|Bacteria,46VNV@74201|Verrucomicrobia,2IW7E@203494|Verrucomicrobiae	203494|Verrucomicrobiae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_2524036_17	1122137.AQXF01000003_gene2307	1.965e-19	104.0	COG4783@1|root,COG4783@2|Bacteria,1QUMJ@1224|Proteobacteria,2TXU6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Peptidase family M48	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
HKD3_k127_2524036_10	221288.JH992901_gene2934	1.627e-63	245.0	COG0457@1|root,COG4995@1|root,COG0457@2|Bacteria,COG4995@2|Bacteria,1G135@1117|Cyanobacteria,1JKJ2@1189|Stigonemataceae	1117|Cyanobacteria	S	CHAT domain	-	-	-	-	-	-	-	-	-	-	-	-	CHAT,TPR_12,TPR_7,TPR_8
HKD3_k127_2581288_1	497964.CfE428DRAFT_2172	1.02e-126	417.0	COG1058@1|root,COG1546@1|root,COG1058@2|Bacteria,COG1546@2|Bacteria,46SRG@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Competence-damaged protein	cinA	-	3.5.1.42	ko:K03742	ko00760,map00760	-	R02322	RC00100	ko00000,ko00001,ko01000	-	-	-	CinA,MoCF_biosynth
HKD3_k127_2581288_0	497964.CfE428DRAFT_2713	3.773e-226	706.0	COG1219@1|root,COG1219@2|Bacteria,46SIK@74201|Verrucomicrobia	74201|Verrucomicrobia	O	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP	clpX	-	-	ko:K03544	ko04112,map04112	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA_2,ClpB_D2-small,zf-C4_ClpX
HKD3_k127_2581288_3	497964.CfE428DRAFT_2712	2.901e-99	329.0	COG0740@1|root,COG0740@2|Bacteria,46SAB@74201|Verrucomicrobia	74201|Verrucomicrobia	OU	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins	clpP	-	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	CLP_protease
HKD3_k127_2581288_2	497964.CfE428DRAFT_2711	7.363e-114	381.0	COG0544@1|root,COG0544@2|Bacteria,46SJZ@74201|Verrucomicrobia	74201|Verrucomicrobia	D	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase	tig	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03545	-	-	-	-	ko00000	-	-	-	FKBP_C,Trigger_C,Trigger_N
HKD3_k127_2581288_4	1382359.JIAL01000001_gene2085	3.252e-74	254.0	COG1228@1|root,COG1228@2|Bacteria,3Y3BK@57723|Acidobacteria,2JKVY@204432|Acidobacteriia	204432|Acidobacteriia	Q	Amidohydrolase family	hutI	-	3.5.2.7	ko:K01468	ko00340,ko01100,map00340,map01100	M00045	R02288	RC00683	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
HKD3_k127_2629508_0	452637.Oter_1616	2.685e-129	427.0	COG0642@1|root,COG2205@2|Bacteria,46TFN@74201|Verrucomicrobia	74201|Verrucomicrobia	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
HKD3_k127_2711063_1	497964.CfE428DRAFT_2215	6.64e-97	335.0	COG1524@1|root,COG1524@2|Bacteria	2|Bacteria	S	mannose-ethanolamine phosphotransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
HKD3_k127_2711063_2	497964.CfE428DRAFT_1796	2.656e-77	271.0	COG0169@1|root,COG0169@2|Bacteria,46SVF@74201|Verrucomicrobia	74201|Verrucomicrobia	E	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)	aroE	-	1.1.1.25	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413	RC00206	ko00000,ko00001,ko00002,ko01000	-	-	-	Shikimate_DH,Shikimate_dh_N
HKD3_k127_2711063_0	497964.CfE428DRAFT_5501	4.961e-140	457.0	COG0008@1|root,COG0008@2|Bacteria,46S4X@74201|Verrucomicrobia	74201|Verrucomicrobia	J	glutaminyl-tRNA synthetase	glnS	-	6.1.1.18	ko:K01886	ko00970,ko01100,map00970,map01100	M00359,M00360	R03652	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1c,tRNA-synt_1c_C
HKD3_k127_28569_22	497964.CfE428DRAFT_4864	8.787e-23	106.0	COG1595@1|root,COG1595@2|Bacteria,46VE8@74201|Verrucomicrobia	74201|Verrucomicrobia	K	DNA-templated transcription, initiation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_28569_2	478741.JAFS01000002_gene442	6.155e-134	435.0	COG4864@1|root,COG4864@2|Bacteria,46TWZ@74201|Verrucomicrobia,37FZ0@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	S	SigmaW regulon antibacterial	-	-	-	-	-	-	-	-	-	-	-	-	YdfA_immunity
HKD3_k127_28569_33	309799.DICTH_0765	3.477e-05	54.0	COG0613@1|root,COG0613@2|Bacteria	2|Bacteria	Q	PHP domain protein	-	-	3.1.3.97	ko:K07053	-	-	R00188,R11188	RC00078	ko00000,ko01000	-	-	-	AAA_21,AAA_23,AlbA_2,PHP,PHP_C
HKD3_k127_28569_3	497964.CfE428DRAFT_4457	8.685e-134	452.0	COG5427@1|root,COG5427@2|Bacteria	2|Bacteria	M	chaperone-mediated protein folding	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_28569_5	497964.CfE428DRAFT_4456	3.465e-129	432.0	COG4745@1|root,COG4745@2|Bacteria,46T45@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HKD3_k127_28569_4	634956.Geoth_0303	9.673e-130	422.0	COG1088@1|root,COG1088@2|Bacteria,1TPWM@1239|Firmicutes,4HA3Y@91061|Bacilli,1WHF3@129337|Geobacillus	91061|Bacilli	M	Male sterility protein	-	-	4.2.1.46	ko:K01710	ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130	M00793	R06513	RC00402	ko00000,ko00001,ko00002,ko01000	-	-	-	GDP_Man_Dehyd
HKD3_k127_28569_8	497964.CfE428DRAFT_4453	5.677e-92	310.0	COG1091@1|root,COG1091@2|Bacteria,46T6F@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose	-	-	1.1.1.133	ko:K00067	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R02777	RC00182	ko00000,ko00001,ko00002,ko01000	-	-	-	RmlD_sub_bind
HKD3_k127_28569_18	497964.CfE428DRAFT_0576	5.457e-30	127.0	COG2010@1|root,COG2010@2|Bacteria,46W2Y@74201|Verrucomicrobia	74201|Verrucomicrobia	C	Protein of unknown function (DUF1573)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1573
HKD3_k127_28569_19	278957.ABEA03000133_gene1595	8.212e-25	109.0	COG0607@1|root,COG0607@2|Bacteria,46WVZ@74201|Verrucomicrobia,3K8HQ@414999|Opitutae	414999|Opitutae	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
HKD3_k127_28569_26	240016.ABIZ01000001_gene3464	7.519e-18	90.0	COG2259@1|root,COG2259@2|Bacteria,46WSE@74201|Verrucomicrobia,2IWGT@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Methylamine utilisation protein MauE	-	-	-	-	-	-	-	-	-	-	-	-	MauE
HKD3_k127_28569_32	1235797.C816_00211	1.051e-06	60.0	COG0265@1|root,COG0265@2|Bacteria,1UZ8K@1239|Firmicutes,24N2F@186801|Clostridia,2N6Z1@216572|Oscillospiraceae	186801|Clostridia	O	Trypsin	-	-	-	-	-	-	-	-	-	-	-	-	Cu_amine_oxidN1,DUF5050,RsgI_N,Trypsin_2
HKD3_k127_28569_14	1185652.USDA257_c02200	7.54e-47	175.0	COG1247@1|root,COG1247@2|Bacteria,1RDF5@1224|Proteobacteria,2U73C@28211|Alphaproteobacteria,4BDAB@82115|Rhizobiaceae	28211|Alphaproteobacteria	M	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_4
HKD3_k127_28569_12	700598.Niako_4073	3.883e-70	245.0	COG3945@1|root,COG3945@2|Bacteria,4NWY3@976|Bacteroidetes	976|Bacteroidetes	S	hemerythrin HHE cation binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
HKD3_k127_28569_0	583355.Caka_2459	2.366e-209	668.0	COG0449@1|root,COG0449@2|Bacteria,46S94@74201|Verrucomicrobia,3K75B@414999|Opitutae	414999|Opitutae	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
HKD3_k127_28569_1	497964.CfE428DRAFT_4290	1.09e-188	600.0	COG0448@1|root,COG0448@2|Bacteria,46SG2@74201|Verrucomicrobia	74201|Verrucomicrobia	G	Belongs to the bacterial plant glucose-1-phosphate adenylyltransferase family	glgC	-	2.7.7.27	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	M00565	R00948	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
HKD3_k127_28569_16	497964.CfE428DRAFT_3181	3.238e-37	147.0	COG1595@1|root,COG1595@2|Bacteria,46VRK@74201|Verrucomicrobia	74201|Verrucomicrobia	K	TIGRFAM RNA polymerase sigma factor, sigma-70 family	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD3_k127_28569_27	1088869.GMO_11950	1.516e-12	68.0	2E4YG@1|root,32ZSB@2|Bacteria,1N74T@1224|Proteobacteria,2UGKQ@28211|Alphaproteobacteria,2JUN0@204441|Rhodospirillales	204441|Rhodospirillales	S	Protein of unknown function (DUF3309)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3309
HKD3_k127_28569_23	497964.CfE428DRAFT_3996	1.206e-22	98.0	COG3237@1|root,COG3237@2|Bacteria	2|Bacteria	K	CsbD-like	yjbJ	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	-	-	-	-	-	-	-	-	-	CsbD
HKD3_k127_28569_25	497964.CfE428DRAFT_6257	2.779e-18	90.0	2CDIR@1|root,348KT@2|Bacteria,46W4H@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_28569_20	497964.CfE428DRAFT_6257	3.706e-24	105.0	2CDIR@1|root,348KT@2|Bacteria,46W4H@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_28569_10	497964.CfE428DRAFT_0460	1.572e-78	268.0	COG1801@1|root,COG1801@2|Bacteria,46V5F@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Protein of unknown function DUF72	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
HKD3_k127_28569_29	1403819.BATR01000009_gene291	3.518e-09	65.0	2C7J2@1|root,33AYB@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_28569_9	497964.CfE428DRAFT_2158	7.157e-84	284.0	COG0325@1|root,COG0325@2|Bacteria,46SV2@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis	-	-	-	ko:K06997	-	-	-	-	ko00000	-	-	-	Ala_racemase_N
HKD3_k127_28569_15	497964.CfE428DRAFT_2157	7.016e-44	161.0	COG3536@1|root,COG3536@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF971)	-	-	-	ko:K03593	-	-	-	-	ko00000,ko03029,ko03036	-	-	-	DUF971
HKD3_k127_28569_7	497964.CfE428DRAFT_2155	3.212e-99	334.0	COG1482@1|root,COG1482@2|Bacteria,46SVM@74201|Verrucomicrobia	74201|Verrucomicrobia	G	PFAM mannose-6-phosphate isomerase type I	manA	-	5.3.1.8	ko:K01809	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114	R01819	RC00376	ko00000,ko00001,ko00002,ko01000	-	-	-	PMI_typeI
HKD3_k127_28569_24	56780.SYN_03077	1.82e-20	97.0	COG5652@1|root,COG5652@2|Bacteria,1PUUC@1224|Proteobacteria,43F3B@68525|delta/epsilon subdivisions,2X381@28221|Deltaproteobacteria,2MSC7@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	VanZ like family	-	-	-	-	-	-	-	-	-	-	-	-	VanZ
HKD3_k127_28569_6	234267.Acid_1100	4.809e-125	415.0	COG1696@1|root,COG1696@2|Bacteria,3Y4S9@57723|Acidobacteria	57723|Acidobacteria	M	PFAM membrane bound O-acyl transferase MBOAT	-	-	-	-	-	-	-	-	-	-	-	-	MBOAT
HKD3_k127_28569_11	497964.CfE428DRAFT_6017	3.416e-71	246.0	COG1432@1|root,COG1432@2|Bacteria	2|Bacteria	S	NYN domain	-	-	-	-	-	-	-	-	-	-	-	-	CSD,NYN
HKD3_k127_28569_13	1123399.AQVE01000011_gene1258	2.237e-55	214.0	COG3209@1|root,COG5295@1|root,COG3209@2|Bacteria,COG5295@2|Bacteria,1N4WT@1224|Proteobacteria	1224|Proteobacteria	UW	cellulase activity	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S74
HKD3_k127_28569_21	497964.CfE428DRAFT_0420	2.622e-23	102.0	2AY99@1|root,31QBJ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_28569_28	1235457.C404_23980	5.452e-10	62.0	2AY99@1|root,31QBJ@2|Bacteria,1RI92@1224|Proteobacteria,2VSPH@28216|Betaproteobacteria,1K7SH@119060|Burkholderiaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_2883918_13	555779.Dthio_PD0754	9.888e-10	59.0	2AFHA@1|root,315HT@2|Bacteria,1N31Y@1224|Proteobacteria,43DNR@68525|delta/epsilon subdivisions,2X6MU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	23S rRNA-intervening sequence protein	-	-	-	-	-	-	-	-	-	-	-	-	23S_rRNA_IVP
HKD3_k127_2883918_12	933262.AXAM01000160_gene290	1.284e-13	74.0	2AFHA@1|root,315HT@2|Bacteria,1N31Y@1224|Proteobacteria,43DNR@68525|delta/epsilon subdivisions,2X6MU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	23S rRNA-intervening sequence protein	-	-	-	-	-	-	-	-	-	-	-	-	23S_rRNA_IVP
HKD3_k127_2883918_5	717785.HYPMC_3134	4.355e-100	341.0	COG0438@1|root,COG0438@2|Bacteria,1MWEM@1224|Proteobacteria,2U1NW@28211|Alphaproteobacteria,3N8M7@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Glycosyl transferase 4-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
HKD3_k127_2883918_9	313624.NSP_23120	4.191e-41	160.0	COG2227@1|root,COG2227@2|Bacteria	2|Bacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	-	-	2.1.1.222,2.1.1.64	ko:K00568	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04988,R05614,R08769,R08781	RC00003,RC00392,RC01895	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_11,Methyltransf_23
HKD3_k127_2883918_7	768671.ThimaDRAFT_0455	6.699e-90	311.0	COG0438@1|root,COG0438@2|Bacteria,1RF49@1224|Proteobacteria,1SHY6@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_1
HKD3_k127_2883918_0	234267.Acid_2647	0.0	1299.0	COG4409@1|root,COG4447@1|root,COG4409@2|Bacteria,COG4447@2|Bacteria,3Y6ZR@57723|Acidobacteria	57723|Acidobacteria	M	Sortilin, neurotensin receptor 3,	-	-	-	-	-	-	-	-	-	-	-	-	Sortilin-Vps10
HKD3_k127_2883918_8	234267.Acid_2646	6.569e-53	196.0	COG2834@1|root,COG2834@2|Bacteria,3Y7NW@57723|Acidobacteria	57723|Acidobacteria	M	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_2883918_15	1267535.KB906767_gene5029	4.942e-08	60.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HKD3_k127_2883918_11	452637.Oter_1875	8.844e-16	82.0	COG0577@1|root,COG0577@2|Bacteria,46TJI@74201|Verrucomicrobia	74201|Verrucomicrobia	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HKD3_k127_2883918_2	452637.Oter_1883	1.12e-190	623.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HKD3_k127_2883918_4	452637.Oter_1995	1.959e-163	542.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HKD3_k127_2883918_16	1267534.KB906754_gene3787	6.558e-06	49.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HKD3_k127_2883918_3	1183438.GKIL_4354	4.548e-168	557.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HKD3_k127_2883918_1	452637.Oter_1890	2.821e-261	830.0	COG0577@1|root,COG0577@2|Bacteria,46UZM@74201|Verrucomicrobia	74201|Verrucomicrobia	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HKD3_k127_2883918_6	234267.Acid_6478	2.674e-93	313.0	COG1136@1|root,COG1136@2|Bacteria,3Y2X0@57723|Acidobacteria	57723|Acidobacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
HKD3_k127_2883918_10	661478.OP10G_4489	3.905e-18	91.0	2A52F@1|root,30TQU@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_2883918_14	861299.J421_0282	4.774e-08	55.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HKD3_k127_2888833_12	497964.CfE428DRAFT_6520	5.176e-13	70.0	COG0811@1|root,COG0811@2|Bacteria,46T1R@74201|Verrucomicrobia	74201|Verrucomicrobia	U	MotA/TolQ/ExbB proton channel family	-	-	-	ko:K03561	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	MotA_ExbB
HKD3_k127_2888833_11	497964.CfE428DRAFT_6519	9.592e-30	124.0	COG0848@1|root,COG0848@2|Bacteria,46T7H@74201|Verrucomicrobia	74201|Verrucomicrobia	U	Biopolymer transport protein ExbD/TolR	-	-	-	ko:K03559	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	ExbD
HKD3_k127_2888833_9	497964.CfE428DRAFT_6518	1.296e-59	212.0	COG0242@1|root,COG0242@2|Bacteria,46SYF@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions	def	-	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	Pep_deformylase
HKD3_k127_2888833_3	497964.CfE428DRAFT_0655	8.227e-127	414.0	COG2022@1|root,COG2022@2|Bacteria,46SHY@74201|Verrucomicrobia	74201|Verrucomicrobia	H	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S	thiG	-	2.8.1.10	ko:K03149	ko00730,ko01100,map00730,map01100	-	R10247	RC03096,RC03097,RC03461	ko00000,ko00001,ko01000	-	-	-	ThiG
HKD3_k127_2888833_5	1396141.BATP01000003_gene4990	1.678e-102	341.0	COG0863@1|root,COG2189@1|root,COG0863@2|Bacteria,COG2189@2|Bacteria,46TXQ@74201|Verrucomicrobia	74201|Verrucomicrobia	L	DNA methylase	-	-	-	-	-	-	-	-	-	-	-	-	N6_N4_Mtase
HKD3_k127_2888833_1	497964.CfE428DRAFT_3455	2.212e-206	661.0	COG0859@1|root,COG1560@1|root,COG0859@2|Bacteria,COG1560@2|Bacteria,46SSR@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Glycosyltransferase family 9 (heptosyltransferase)	-	-	2.3.1.241	ko:K02517,ko:K02843	ko00540,ko01100,map00540,map01100	M00060,M00080	R05146	RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9,Lip_A_acyltrans
HKD3_k127_2888833_2	572546.Arcpr_1207	3.124e-138	464.0	COG0463@1|root,COG0500@1|root,COG1216@1|root,arCOG01384@2157|Archaea,arCOG04220@2157|Archaea,arCOG04347@2157|Archaea	2157|Archaea	Q	Methyltransferase type 11	-	-	-	ko:K20444	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.1.3	GT2,GT4	-	Glyco_trans_1_2,Glycos_transf_2,Methyltransf_11
HKD3_k127_2888833_6	1396418.BATQ01000017_gene4184	1.024e-86	293.0	29RX9@1|root,30D1E@2|Bacteria,46ZJJ@74201|Verrucomicrobia,2IV9H@203494|Verrucomicrobiae	203494|Verrucomicrobiae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_2888833_8	497964.CfE428DRAFT_5941	2.557e-76	261.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25,Methyltransf_31
HKD3_k127_2888833_0	448385.sce6769	3.186e-232	725.0	COG3391@1|root,COG3391@2|Bacteria,1MXDX@1224|Proteobacteria,42Y5B@68525|delta/epsilon subdivisions,2WU9D@28221|Deltaproteobacteria,2Z155@29|Myxococcales	28221|Deltaproteobacteria	S	Selenium-binding protein	-	-	-	ko:K17285	-	-	-	-	ko00000,ko04147	-	-	-	SBP56
HKD3_k127_2888833_10	1267533.KB906738_gene2316	4.091e-57	207.0	2AI77@1|root,318MJ@2|Bacteria,3Y7RV@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_2888833_7	497964.CfE428DRAFT_5928	8.261e-77	266.0	COG0414@1|root,COG0414@2|Bacteria,46SRN@74201|Verrucomicrobia	74201|Verrucomicrobia	H	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate	panC	-	6.3.2.1	ko:K01918	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R02473	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_ligase
HKD3_k127_2888833_4	497964.CfE428DRAFT_5926	9.82e-113	374.0	COG3868@1|root,COG3868@2|Bacteria,46STS@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Glycoside-hydrolase family GH114	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_2934080_0	344747.PM8797T_23024	3.673e-73	251.0	COG0406@1|root,COG0406@2|Bacteria,2IZ7M@203682|Planctomycetes	203682|Planctomycetes	G	Phosphoglycerate mutase family	-	-	-	-	-	-	-	-	-	-	-	-	His_Phos_1
HKD3_k127_2934080_1	497964.CfE428DRAFT_2395	1.995e-25	111.0	COG1943@1|root,COG1943@2|Bacteria,46VNW@74201|Verrucomicrobia	74201|Verrucomicrobia	L	Transposase IS200 like	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
HKD3_k127_2936265_3	452637.Oter_0107	1.68e-50	184.0	COG2761@1|root,COG2761@2|Bacteria	2|Bacteria	Q	protein disulfide oxidoreductase activity	frnE	-	-	-	-	-	-	-	-	-	-	-	DSBA
HKD3_k127_2936265_2	497964.CfE428DRAFT_5294	1.694e-71	246.0	COG0290@1|root,COG0290@2|Bacteria,46SU6@74201|Verrucomicrobia	74201|Verrucomicrobia	J	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins	infC	-	-	ko:K02520	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	IF3_C,IF3_N
HKD3_k127_2936265_4	1170562.Cal6303_0957	3.359e-06	57.0	COG0457@1|root,COG0457@2|Bacteria,1G4J0@1117|Cyanobacteria,1HJ4A@1161|Nostocales	1117|Cyanobacteria	O	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_11,TPR_8,Trypsin_2
HKD3_k127_2936265_0	497964.CfE428DRAFT_2305	3.705e-117	383.0	COG1692@1|root,COG1692@2|Bacteria,46SQ2@74201|Verrucomicrobia	74201|Verrucomicrobia	S	YmdB-like protein	-	-	-	ko:K09769	-	-	-	-	ko00000	-	-	-	YmdB
HKD3_k127_2936265_1	497964.CfE428DRAFT_6073	1.212e-92	315.0	COG0860@1|root,COG0860@2|Bacteria,46SKJ@74201|Verrucomicrobia	74201|Verrucomicrobia	M	N-acetylmuramoyl-L-alanine amidase	-	-	-	-	-	-	-	-	-	-	-	-	Amidase_3
HKD3_k127_29425_2	886293.Sinac_0736	1.019e-111	381.0	COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,2IYAH@203682|Planctomycetes	203682|Planctomycetes	C	FAD linked oxidases, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG,FAD-oxidase_C,FAD_binding_4,Fer4_17,Fer4_8
HKD3_k127_29425_1	583355.Caka_1506	6.227e-117	392.0	COG0389@1|root,COG0389@2|Bacteria,46SNK@74201|Verrucomicrobia,3K7SQ@414999|Opitutae	414999|Opitutae	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	dinB	-	2.7.7.7	ko:K02346	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C,IMS_HHH
HKD3_k127_29425_0	497964.CfE428DRAFT_2230	5.686e-272	849.0	COG0843@1|root,COG0843@2|Bacteria,46S4Q@74201|Verrucomicrobia	74201|Verrucomicrobia	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	-	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
HKD3_k127_29425_4	497964.CfE428DRAFT_2231	1.752e-108	358.0	COG1845@1|root,COG1845@2|Bacteria,46SRD@74201|Verrucomicrobia	74201|Verrucomicrobia	C	Cytochrome c oxidase subunit III	cyoC	-	1.9.3.1	ko:K02276	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.4,3.D.4.6	-	-	COX3
HKD3_k127_29425_9	240016.ABIZ01000001_gene2011	1.039e-09	63.0	2DR0H@1|root,339NS@2|Bacteria,46ZIA@74201|Verrucomicrobia,2IUYZ@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Prokaryotic Cytochrome C oxidase subunit IV	-	-	-	-	-	-	-	-	-	-	-	-	COX4_pro
HKD3_k127_29425_5	497964.CfE428DRAFT_2235	8.746e-95	318.0	COG1622@1|root,COG1622@2|Bacteria,46SPQ@74201|Verrucomicrobia	74201|Verrucomicrobia	C	Cytochrome C oxidase subunit II, periplasmic domain	-	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2
HKD3_k127_29425_6	481448.Minf_1426	2.548e-68	248.0	COG1612@1|root,COG1612@2|Bacteria,46T3F@74201|Verrucomicrobia,37G83@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	O	Cytochrome oxidase assembly protein	ctaA	-	-	ko:K02259	ko00190,ko00860,ko01100,ko01110,ko02020,ko04714,map00190,map00860,map01100,map01110,map02020,map04714	M00154	R07412	RC00769	ko00000,ko00001,ko00002,ko03029	3.D.4.4	-	-	COX15-CtaA
HKD3_k127_29425_7	497964.CfE428DRAFT_2237	3.906e-66	236.0	COG0109@1|root,COG0109@2|Bacteria,46SQE@74201|Verrucomicrobia	74201|Verrucomicrobia	O	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group	ctaB	-	2.5.1.141	ko:K02257	ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714	M00154	R07411	RC01786	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029	-	-	-	UbiA
HKD3_k127_29425_8	497964.CfE428DRAFT_2238	3.346e-45	175.0	COG1999@1|root,COG1999@2|Bacteria,46VZB@74201|Verrucomicrobia	74201|Verrucomicrobia	S	SCO1/SenC	-	-	-	ko:K07152	-	-	-	-	ko00000,ko03029	-	-	-	SCO1-SenC
HKD3_k127_29425_3	443143.GM18_2322	2.182e-111	368.0	COG1209@1|root,COG1209@2|Bacteria,1MU0X@1224|Proteobacteria,42MTN@68525|delta/epsilon subdivisions,2WJAI@28221|Deltaproteobacteria,43S7Y@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis	rmlA	-	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
HKD3_k127_295033_5	794903.OPIT5_09785	1.916e-29	122.0	COG0346@1|root,COG0346@2|Bacteria,46VWA@74201|Verrucomicrobia	74201|Verrucomicrobia	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HKD3_k127_295033_2	497964.CfE428DRAFT_2160	9.645e-133	428.0	COG0005@1|root,COG0005@2|Bacteria,46UP8@74201|Verrucomicrobia	74201|Verrucomicrobia	F	Phosphorylase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PNP_UDP_1
HKD3_k127_295033_0	497964.CfE428DRAFT_3537	7.641e-202	638.0	COG0621@1|root,COG0621@2|Bacteria,46S6B@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine	miaB	-	2.8.4.3	ko:K06168	-	-	R10645,R10646,R10647	RC00003,RC00980,RC03221,RC03222	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
HKD3_k127_295033_4	497964.CfE428DRAFT_3563	1.27e-41	159.0	2EEN4@1|root,338G1@2|Bacteria,46T5X@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_295033_3	497964.CfE428DRAFT_1693	9.119e-96	322.0	COG0859@1|root,COG0859@2|Bacteria,46SZK@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Glycosyltransferase family 9 (heptosyltransferase)	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_9
HKD3_k127_295033_1	497964.CfE428DRAFT_2042	2.207e-156	498.0	COG1087@1|root,COG1087@2|Bacteria,46SIR@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Belongs to the NAD(P)-dependent epimerase dehydratase family	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
HKD3_k127_2963634_13	1442599.JAAN01000026_gene1304	9.659e-05	51.0	COG1652@1|root,COG4254@1|root,COG1652@2|Bacteria,COG4254@2|Bacteria,1NKA2@1224|Proteobacteria,1S1E7@1236|Gammaproteobacteria,1X3DI@135614|Xanthomonadales	135614|Xanthomonadales	S	FecR protein	-	-	-	-	-	-	-	-	-	-	-	-	FecR,LysM
HKD3_k127_2963634_12	1304878.AUGD01000030_gene3665	3.364e-06	53.0	COG3659@1|root,COG3659@2|Bacteria,1Q8C7@1224|Proteobacteria,2TU66@28211|Alphaproteobacteria,3JRBM@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	M	Carbohydrate-selective porin, OprB family	-	-	-	ko:K16080	-	-	-	-	ko00000,ko02000	1.B.4.2.2	-	-	OMP_b-brl,OprB
HKD3_k127_2963634_8	1040989.AWZU01000016_gene2475	1.045e-21	99.0	COG3637@1|root,COG3659@1|root,COG3637@2|Bacteria,COG3659@2|Bacteria,1Q8C7@1224|Proteobacteria,2TU66@28211|Alphaproteobacteria,3JRBM@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	M	Carbohydrate-selective porin, OprB family	-	-	-	ko:K16080	-	-	-	-	ko00000,ko02000	1.B.4.2.2	-	-	OMP_b-brl,OprB
HKD3_k127_2963634_6	497964.CfE428DRAFT_5881	1.018e-54	205.0	COG4585@1|root,COG4585@2|Bacteria,46V1V@74201|Verrucomicrobia	74201|Verrucomicrobia	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA_3
HKD3_k127_2963634_5	518766.Rmar_2227	2.117e-58	210.0	COG2197@1|root,COG2197@2|Bacteria,4NP2G@976|Bacteroidetes,1FIR1@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HKD3_k127_2963634_0	497964.CfE428DRAFT_1374	1.665e-68	248.0	COG0582@1|root,COG0582@2|Bacteria	2|Bacteria	L	DNA integration	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	Phage_int_SAM_3,Phage_integrase
HKD3_k127_2963634_7	880073.Calab_1665	1.292e-35	149.0	COG0697@1|root,COG0697@2|Bacteria,2NPZZ@2323|unclassified Bacteria	2|Bacteria	EG	EamA-like transporter family	pagO	-	-	ko:K07790	ko02020,map02020	-	-	-	ko00000,ko00001	2.A.7	-	-	EamA
HKD3_k127_2963634_2	247490.KSU1_D0551	1.209e-62	226.0	28MCN@1|root,2ZAQR@2|Bacteria,2J327@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_2963634_1	765912.Thimo_1501	2.178e-68	258.0	COG1752@1|root,COG1752@2|Bacteria,1RBKJ@1224|Proteobacteria,1SN6B@1236|Gammaproteobacteria,1X0KP@135613|Chromatiales	135613|Chromatiales	S	Esterase of the alpha-beta hydrolase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_2963634_10	929556.Solca_3101	1.378e-12	73.0	2ER3W@1|root,33IPG@2|Bacteria,4NYM0@976|Bacteroidetes,1J030@117747|Sphingobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_2963634_11	398720.MED217_08580	4.315e-12	72.0	2E2RH@1|root,32XTZ@2|Bacteria,4NTV2@976|Bacteroidetes,1I4NN@117743|Flavobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_2963634_3	1123070.KB899264_gene1794	1.25e-59	213.0	COG3209@1|root,COG3209@2|Bacteria	2|Bacteria	M	self proteolysis	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_75,Peptidase_S74,YadA_head
HKD3_k127_2963634_9	710686.Mycsm_05230	4.933e-13	70.0	COG3103@1|root,COG3103@2|Bacteria,2IGZN@201174|Actinobacteria	201174|Actinobacteria	T	Sh3 type 3 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_296418_0	497964.CfE428DRAFT_5484	2.605e-202	643.0	COG0323@1|root,COG0323@2|Bacteria,46SG5@74201|Verrucomicrobia	74201|Verrucomicrobia	L	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex	mutL	-	-	ko:K03572	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	DNA_mis_repair,HATPase_c_3,MutL_C
HKD3_k127_296418_1	517418.Ctha_2687	7.789e-22	98.0	COG0316@1|root,COG0316@2|Bacteria,1FF80@1090|Chlorobi	1090|Chlorobi	S	Belongs to the HesB IscA family	-	-	-	ko:K13628	-	-	-	-	ko00000,ko03016	-	-	-	Fe-S_biosyn
HKD3_k127_3028457_4	1336243.JAEA01000018_gene3329	3.931e-09	61.0	COG0265@1|root,COG1073@1|root,COG0265@2|Bacteria,COG1073@2|Bacteria,1PRXP@1224|Proteobacteria,2U2Q7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Domain present in PSD-95, Dlg, and ZO-1/2.	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4,PDZ_2
HKD3_k127_3028457_1	497964.CfE428DRAFT_4129	1.327e-30	126.0	COG0346@1|root,COG0346@2|Bacteria,46T5V@74201|Verrucomicrobia	74201|Verrucomicrobia	E	PFAM Glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HKD3_k127_3028457_3	278957.ABEA03000094_gene4684	4.964e-23	102.0	COG0346@1|root,COG0346@2|Bacteria,46T5V@74201|Verrucomicrobia,3K8BB@414999|Opitutae	414999|Opitutae	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HKD3_k127_3028457_0	562970.Btus_1483	3.352e-126	410.0	COG0074@1|root,COG0074@2|Bacteria,1TPIT@1239|Firmicutes,4HA2J@91061|Bacilli,2792C@186823|Alicyclobacillaceae	91061|Bacilli	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit	sucD	-	6.2.1.5	ko:K01902	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_binding,Ligase_CoA
HKD3_k127_3028457_2	1128427.KB904821_gene4391	5.872e-24	106.0	COG0673@1|root,COG0673@2|Bacteria,1G1CZ@1117|Cyanobacteria,1HEFX@1150|Oscillatoriales	1117|Cyanobacteria	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
HKD3_k127_3079631_7	383372.Rcas_0560	2.743e-83	292.0	COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,2G5ZQ@200795|Chloroflexi,376AA@32061|Chloroflexia	32061|Chloroflexia	C	FAD linked oxidase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CCG,FAD-oxidase_C,FAD_binding_4,Fer4_8
HKD3_k127_3079631_12	497964.CfE428DRAFT_2227	7.053e-46	177.0	COG2010@1|root,COG2010@2|Bacteria,46T74@74201|Verrucomicrobia	74201|Verrucomicrobia	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C
HKD3_k127_3079631_13	497964.CfE428DRAFT_2226	7.798e-43	169.0	COG2993@1|root,COG2993@2|Bacteria,46T1F@74201|Verrucomicrobia	74201|Verrucomicrobia	C	PFAM cytochrome C oxidase mono-heme subunit FixO	ccoO	-	-	ko:K00405	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002	3.D.4.3	-	-	FixO
HKD3_k127_3079631_2	1123508.JH636443_gene5055	1.205e-147	482.0	COG3278@1|root,COG3278@2|Bacteria,2IY0E@203682|Planctomycetes	203682|Planctomycetes	C	COGs COG3278 Cbb3-type cytochrome oxidase subunit 1	-	-	-	-	-	-	-	-	-	-	-	-	COX1
HKD3_k127_3079631_4	497964.CfE428DRAFT_2222	9.288e-109	365.0	COG4531@1|root,COG4531@2|Bacteria,46SME@74201|Verrucomicrobia	74201|Verrucomicrobia	P	ABC-type Zn2 transport system, periplasmic component surface adhesin	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_3079631_10	497964.CfE428DRAFT_2221	5.189e-65	229.0	COG2010@1|root,COG2010@2|Bacteria,46SV4@74201|Verrucomicrobia	74201|Verrucomicrobia	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
HKD3_k127_3079631_8	497964.CfE428DRAFT_2220	5.562e-75	257.0	COG2010@1|root,COG2010@2|Bacteria,46VEQ@74201|Verrucomicrobia	74201|Verrucomicrobia	C	Protein of unknown function (DUF3341)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3341
HKD3_k127_3079631_1	497964.CfE428DRAFT_2219	5.038e-216	679.0	COG5557@1|root,COG5557@2|Bacteria,46S9S@74201|Verrucomicrobia	74201|Verrucomicrobia	C	PFAM Polysulphide reductase NrfD	-	-	-	ko:K00185	-	-	-	-	ko00000	5.A.3	-	-	DUF3341,NrfD
HKD3_k127_3079631_0	497964.CfE428DRAFT_2218	0.0	1111.0	COG0437@1|root,COG0437@2|Bacteria,46S66@74201|Verrucomicrobia	74201|Verrucomicrobia	C	4Fe-4S dicluster domain	hybA	-	-	ko:K00184	-	-	-	-	ko00000	5.A.3	-	-	Fer4_7
HKD3_k127_3079631_3	497964.CfE428DRAFT_2217	5.157e-110	360.0	COG3880@1|root,COG3880@2|Bacteria,46SMN@74201|Verrucomicrobia	74201|Verrucomicrobia	C	Cytochrome c7 and related cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C7
HKD3_k127_3079631_11	497964.CfE428DRAFT_4975	2.109e-63	231.0	COG0354@1|root,COG0354@2|Bacteria,46T24@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Belongs to the GcvT family	-	-	-	ko:K06980	-	-	-	-	ko00000,ko03016	-	-	-	GCV_T,GCV_T_C
HKD3_k127_3079631_9	497964.CfE428DRAFT_4974	9.978e-75	264.0	COG2084@1|root,COG2084@2|Bacteria,46U4D@74201|Verrucomicrobia	74201|Verrucomicrobia	I	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_11,NAD_binding_2
HKD3_k127_3079631_6	497964.CfE428DRAFT_1801	3.518e-86	295.0	COG2234@1|root,COG2234@2|Bacteria	2|Bacteria	DZ	aminopeptidase activity	ywaD	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
HKD3_k127_3079631_5	497964.CfE428DRAFT_1800	8.104e-94	314.0	COG1475@1|root,COG1475@2|Bacteria,46SQ8@74201|Verrucomicrobia	74201|Verrucomicrobia	K	Belongs to the ParB family	-	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
HKD3_k127_3139447_7	240015.ACP_2101	1.058e-18	87.0	2E27Y@1|root,32XE5@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF3419
HKD3_k127_3139447_0	98439.AJLL01000016_gene1686	0.0	1109.0	COG1042@1|root,COG1670@1|root,COG1042@2|Bacteria,COG1670@2|Bacteria,1G2D3@1117|Cyanobacteria,1JKE4@1189|Stigonemataceae	1117|Cyanobacteria	CJ	CoA binding domain	-	-	-	ko:K09181	-	-	-	-	ko00000	-	-	-	ATP-grasp_5,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig
HKD3_k127_3139447_4	595460.RRSWK_03455	6.618e-102	344.0	COG0845@1|root,COG0845@2|Bacteria,2J07G@203682|Planctomycetes	203682|Planctomycetes	M	Efflux transporter, RND family, MFP subunit	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_3
HKD3_k127_3139447_2	195250.CM001776_gene1527	2.556e-235	752.0	COG0577@1|root,COG0577@2|Bacteria,1G0Z7@1117|Cyanobacteria,1GZYN@1129|Synechococcus	1117|Cyanobacteria	V	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HKD3_k127_3139447_3	748247.AZKH_1669	8.461e-110	359.0	COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,2VJ7G@28216|Betaproteobacteria	28216|Betaproteobacteria	V	abc transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD3_k127_3139447_1	926566.Terro_1107	3.19e-263	841.0	COG0474@1|root,COG0474@2|Bacteria,3Y3ZX@57723|Acidobacteria,2JIQJ@204432|Acidobacteriia	204432|Acidobacteriia	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.6,3.6.3.8	ko:K01535,ko:K01537	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.3.2,3.A.3.3	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
HKD3_k127_3139447_8	309807.SRU_1985	1.235e-18	94.0	COG0589@1|root,COG0589@2|Bacteria,4NFZ5@976|Bacteroidetes,1FJR9@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	T	Belongs to the universal stress protein A family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD3_k127_3139447_6	240016.ABIZ01000001_gene2278	4.364e-39	157.0	COG0589@1|root,COG0589@2|Bacteria,46WCC@74201|Verrucomicrobia	74201|Verrucomicrobia	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD3_k127_3139447_5	530564.Psta_3944	9.416e-81	277.0	COG1858@1|root,COG1858@2|Bacteria,2IY7G@203682|Planctomycetes	203682|Planctomycetes	C	cytochrome c peroxidase	-	-	1.11.1.5	ko:K00428	-	-	-	-	ko00000,ko01000	-	-	-	CCP_MauG,Cytochrom_C
HKD3_k127_3169172_3	859653.HIMB5_00012680	1.092e-26	119.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1,Methyltransf_11,Methyltransf_23,Methyltransf_25
HKD3_k127_3169172_1	203119.Cthe_3097	9.618e-107	357.0	COG1215@1|root,COG1215@2|Bacteria,1UI5W@1239|Firmicutes,25EJ5@186801|Clostridia,3WSJE@541000|Ruminococcaceae	186801|Clostridia	M	Family 2	-	-	-	ko:K20534	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.2.1.9	GT2	-	Glycos_transf_2
HKD3_k127_3169172_2	497964.CfE428DRAFT_4576	3.548e-36	140.0	2EMF0@1|root,33F3U@2|Bacteria,46TA3@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Stress responsive A/B Barrel Domain	-	-	-	-	-	-	-	-	-	-	-	-	Dabb
HKD3_k127_3169172_0	1403819.BATR01000022_gene777	2.495e-123	421.0	COG0438@1|root,COG0438@2|Bacteria,46WZV@74201|Verrucomicrobia,2IW3I@203494|Verrucomicrobiae	203494|Verrucomicrobiae	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
HKD3_k127_3280651_3	497964.CfE428DRAFT_3237	2.092e-13	78.0	COG4969@1|root,COG4969@2|Bacteria,46ZJH@74201|Verrucomicrobia	74201|Verrucomicrobia	NU	Prokaryotic N-terminal methylation motif	-	-	-	-	-	-	-	-	-	-	-	-	N_methyl
HKD3_k127_3280651_0	497964.CfE428DRAFT_4669	1.245e-138	447.0	COG0451@1|root,COG0451@2|Bacteria,46SD9@74201|Verrucomicrobia	74201|Verrucomicrobia	GM	Catalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction	fcl	-	1.1.1.271	ko:K02377	ko00051,ko00520,ko01100,map00051,map00520,map01100	-	R05692	RC01014	ko00000,ko00001,ko01000	-	-	-	Epimerase
HKD3_k127_3280651_1	497964.CfE428DRAFT_0881	1.421e-105	351.0	COG0673@1|root,COG0673@2|Bacteria,46SAE@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Oxidoreductase family, NAD-binding Rossmann fold	mviM	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
HKD3_k127_3280651_2	497964.CfE428DRAFT_0882	5.539e-82	279.0	COG0763@1|root,COG0763@2|Bacteria,46SSG@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxB	-	2.4.1.182	ko:K00748	ko00540,ko01100,map00540,map01100	M00060	R04606	RC00005,RC00059	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT19	-	LpxB
HKD3_k127_3289305_1	497964.CfE428DRAFT_5904	4.459e-65	228.0	COG0307@1|root,COG0307@2|Bacteria,46SU1@74201|Verrucomicrobia	74201|Verrucomicrobia	H	TIGRFAM riboflavin synthase, alpha subunit	ribC	-	2.5.1.9	ko:K00793	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00066	RC00958,RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	Lum_binding
HKD3_k127_3289305_3	522306.CAP2UW1_0553	1.622e-09	61.0	COG1055@1|root,COG1055@2|Bacteria,1PUZK@1224|Proteobacteria,2VKEF@28216|Betaproteobacteria	28216|Betaproteobacteria	P	Involved in arsenical resistance. Thought to form the channel of an arsenite pump	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_3289305_2	595460.RRSWK_06213	2.756e-10	73.0	COG0463@1|root,COG1807@1|root,COG0463@2|Bacteria,COG1807@2|Bacteria,2IZ8J@203682|Planctomycetes	203682|Planctomycetes	M	glycosyl transferase family 39	-	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2,PMT_2
HKD3_k127_3289305_0	1499967.BAYZ01000014_gene6407	1.814e-139	456.0	COG0367@1|root,COG0367@2|Bacteria,2NNKE@2323|unclassified Bacteria	2|Bacteria	E	PFAM asparagine synthase	asnB	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
HKD3_k127_3327329_0	497964.CfE428DRAFT_0045	5.417e-195	621.0	COG0143@1|root,COG0143@2|Bacteria,46SCQ@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Belongs to the class-I aminoacyl-tRNA synthetase family	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g
HKD3_k127_3327329_3	240016.ABIZ01000001_gene1203	8.041e-14	72.0	COG1943@1|root,COG1943@2|Bacteria,46VNW@74201|Verrucomicrobia	74201|Verrucomicrobia	L	Transposase IS200 like	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
HKD3_k127_3327329_4	240016.ABIZ01000001_gene1203	2.274e-08	59.0	COG1943@1|root,COG1943@2|Bacteria,46VNW@74201|Verrucomicrobia	74201|Verrucomicrobia	L	Transposase IS200 like	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
HKD3_k127_3327329_2	643867.Ftrac_0650	2.263e-25	112.0	COG1305@1|root,COG1305@2|Bacteria,4NKII@976|Bacteroidetes,47KZ3@768503|Cytophagia	976|Bacteroidetes	E	Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Transglut_core
HKD3_k127_3327329_1	382464.ABSI01000014_gene1479	2.36e-178	569.0	COG2217@1|root,COG2217@2|Bacteria,46S9Z@74201|Verrucomicrobia,2ITMQ@203494|Verrucomicrobiae	203494|Verrucomicrobiae	P	E1-E2 ATPase	-	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,Hydrolase,YHS
HKD3_k127_3328337_1	497964.CfE428DRAFT_0944	1.277e-28	129.0	COG4258@1|root,COG4258@2|Bacteria,46TC6@74201|Verrucomicrobia	2|Bacteria	S	MMPL family	hpnN	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
HKD3_k127_3328337_0	497964.CfE428DRAFT_4794	4.605e-87	292.0	COG3794@1|root,COG3794@2|Bacteria,46SUG@74201|Verrucomicrobia	74201|Verrucomicrobia	C	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
HKD3_k127_3328337_2	452637.Oter_1616	0.0002547	45.0	COG0642@1|root,COG2205@2|Bacteria,46TFN@74201|Verrucomicrobia	74201|Verrucomicrobia	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
HKD3_k127_3348024_3	497964.CfE428DRAFT_1665	1.196e-78	275.0	COG0392@1|root,COG0392@2|Bacteria,46T31@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Lysylphosphatidylglycerol synthase TM region	-	-	-	ko:K07027	-	-	-	-	ko00000,ko02000	4.D.2	-	-	LPG_synthase_TM
HKD3_k127_3348024_1	497964.CfE428DRAFT_1667	1.248e-108	361.0	COG1082@1|root,COG1082@2|Bacteria,46SWH@74201|Verrucomicrobia	74201|Verrucomicrobia	G	PFAM Xylose isomerase domain protein TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
HKD3_k127_3348024_2	497964.CfE428DRAFT_6174	7.412e-94	323.0	COG0477@1|root,COG2814@2|Bacteria,46T1N@74201|Verrucomicrobia	74201|Verrucomicrobia	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
HKD3_k127_3348024_0	497964.CfE428DRAFT_5976	0.0	1264.0	COG0542@1|root,COG0542@2|Bacteria,46S4S@74201|Verrucomicrobia	74201|Verrucomicrobia	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpB	-	-	ko:K03695	ko04213,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
HKD3_k127_3459236_0	1380394.JADL01000001_gene2827	3.234e-106	365.0	COG3511@1|root,COG3511@2|Bacteria,1MVNS@1224|Proteobacteria,2U1QU@28211|Alphaproteobacteria,2JPJA@204441|Rhodospirillales	204441|Rhodospirillales	M	Phosphoesterase family	-	-	-	-	-	-	-	-	-	-	-	-	Phosphoesterase
HKD3_k127_3459236_1	452662.SJA_C1-12490	8.558e-10	61.0	COG2908@1|root,COG2908@2|Bacteria,1MVKD@1224|Proteobacteria,2TSEB@28211|Alphaproteobacteria,2K0Q8@204457|Sphingomonadales	204457|Sphingomonadales	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos,Metallophos_2
HKD3_k127_35368_4	1122604.JONR01000004_gene851	4.287e-07	53.0	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1T234@1236|Gammaproteobacteria,1X903@135614|Xanthomonadales	135614|Xanthomonadales	S	Adenylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16
HKD3_k127_35368_2	1122603.ATVI01000005_gene3502	4.884e-82	296.0	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1T5SE@1236|Gammaproteobacteria,1XDE6@135614|Xanthomonadales	135614|Xanthomonadales	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_19
HKD3_k127_35368_3	1121875.KB907546_gene2685	1.319e-09	68.0	2E3AK@1|root,31XZF@2|Bacteria,4NRCU@976|Bacteroidetes,1I3MB@117743|Flavobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_35368_1	382464.ABSI01000012_gene2201	2.072e-98	343.0	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria	2|Bacteria	S	cAMP biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	BTAD,TPR_11,TPR_16,TPR_7,TPR_8,Trans_reg_C
HKD3_k127_35368_0	1122604.JONR01000004_gene851	2.193e-111	376.0	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1T234@1236|Gammaproteobacteria,1X903@135614|Xanthomonadales	135614|Xanthomonadales	S	Adenylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16
HKD3_k127_3549769_1	379066.GAU_1288	8.925e-84	291.0	COG1402@1|root,COG1402@2|Bacteria	2|Bacteria	I	creatininase	-	-	3.5.2.10	ko:K01470	ko00330,map00330	-	R01884	RC00615	ko00000,ko00001,ko01000	-	-	-	Creatininase
HKD3_k127_3549769_5	1384054.N790_13360	4.468e-34	137.0	COG0251@1|root,COG0251@2|Bacteria,1MZ3J@1224|Proteobacteria,1S5XS@1236|Gammaproteobacteria,1X6CE@135614|Xanthomonadales	135614|Xanthomonadales	J	endoribonuclease	yjgF	-	-	-	-	-	-	-	-	-	-	-	Ribonuc_L-PSP
HKD3_k127_3549769_7	639030.JHVA01000001_gene3295	1.681e-26	115.0	COG0384@1|root,COG0384@2|Bacteria,3Y4H0@57723|Acidobacteria,2JJ47@204432|Acidobacteriia	204432|Acidobacteriia	S	Phenazine biosynthesis protein, PhzF family	-	-	5.3.3.17	ko:K06998	ko00405,ko01130,ko02024,map00405,map01130,map02024	M00835	-	-	ko00000,ko00001,ko00002,ko01000	-	-	-	PhzC-PhzF
HKD3_k127_3549769_2	452637.Oter_1936	3.571e-81	284.0	COG0582@1|root,COG0582@2|Bacteria,46TD6@74201|Verrucomicrobia,3K9G2@414999|Opitutae	414999|Opitutae	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
HKD3_k127_3549769_0	497964.CfE428DRAFT_4167	2.837e-102	337.0	COG1208@1|root,COG1208@2|Bacteria,46SP1@74201|Verrucomicrobia	74201|Verrucomicrobia	JM	Bacterial transferase hexapeptide (six repeats)	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep
HKD3_k127_3549769_3	1121373.KB903622_gene2860	9.818e-66	232.0	2DKXV@1|root,30THP@2|Bacteria,4NS65@976|Bacteroidetes,47WGS@768503|Cytophagia	976|Bacteroidetes	S	Sulfotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_2
HKD3_k127_3549769_9	1267535.KB906767_gene5189	2.216e-05	53.0	COG0457@1|root,COG0457@2|Bacteria,3Y3BD@57723|Acidobacteria	57723|Acidobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TPR_11,TPR_16,TPR_2,TPR_8
HKD3_k127_3549769_6	631362.Thi970DRAFT_02030	1.23e-26	120.0	COG1226@1|root,32Y28@2|Bacteria,1NEAT@1224|Proteobacteria,1S588@1236|Gammaproteobacteria,1WZEG@135613|Chromatiales	135613|Chromatiales	P	Ion channel	-	-	-	-	-	-	-	-	-	-	-	-	Ion_trans_2
HKD3_k127_3675891_0	1057002.KB905370_gene4587	0.0	1083.0	COG2203@1|root,COG4191@1|root,COG2203@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2V7KJ@28211|Alphaproteobacteria,4BJYD@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
HKD3_k127_3675891_2	113395.AXAI01000020_gene6319	2.969e-08	55.0	COG3064@1|root,COG3064@2|Bacteria,1MXPS@1224|Proteobacteria,2TREX@28211|Alphaproteobacteria,3JSKS@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	M	Protein of unknown function (DUF3300)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3300
HKD3_k127_3675891_1	883078.HMPREF9695_03189	1.049e-27	112.0	COG5400@1|root,COG5400@2|Bacteria,1RASG@1224|Proteobacteria,2U590@28211|Alphaproteobacteria,3JSC3@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1134)	MA20_46305	-	-	-	-	-	-	-	-	-	-	-	DUF1134
HKD3_k127_3682261_0	497964.CfE428DRAFT_3260	1.417e-187	599.0	COG2217@1|root,COG2217@2|Bacteria,46S53@74201|Verrucomicrobia	74201|Verrucomicrobia	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.3,3.6.3.5	ko:K01534	-	-	-	-	ko00000,ko01000	3.A.3.6	-	-	E1-E2_ATPase,Hydrolase
HKD3_k127_369164_3	404589.Anae109_1564	8.461e-19	91.0	COG0667@1|root,COG0667@2|Bacteria,1MVEH@1224|Proteobacteria,42MDR@68525|delta/epsilon subdivisions,2WKUR@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	aldo keto reductase	-	-	1.1.1.65	ko:K05275	ko00750,ko01100,ko01120,map00750,map01100,map01120	-	R01708	RC00116	ko00000,ko00001,ko01000	-	-	-	Aldo_ket_red
HKD3_k127_369164_1	1156937.MFUM_810035	6.65e-45	168.0	COG1528@1|root,COG1528@2|Bacteria,46WDU@74201|Verrucomicrobia,37GM9@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	P	Ferritin-like domain	ftn	-	1.16.3.1,1.16.3.2	ko:K02217,ko:K22336	ko00860,map00860	-	R00078	RC02758	ko00000,ko00001,ko01000	-	-	-	Ferritin
HKD3_k127_369164_2	497964.CfE428DRAFT_4531	1.146e-25	109.0	2CFNS@1|root,331AJ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_369164_0	296591.Bpro_1966	2.133e-72	250.0	COG0433@1|root,COG0433@2|Bacteria,1MU59@1224|Proteobacteria,2VIJY@28216|Betaproteobacteria,4AA9X@80864|Comamonadaceae	28216|Betaproteobacteria	S	Bacterial protein of unknown function (DUF853)	yjgR	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF853
HKD3_k127_3695809_21	348780.NP_4692A	1.937e-07	58.0	COG3794@1|root,arCOG02920@2157|Archaea,2XZW3@28890|Euryarchaeota,23XFP@183963|Halobacteria	183963|Halobacteria	C	Copper binding proteins, plastocyanin/azurin family	-	-	-	-	-	-	-	-	-	-	-	-	Copper-bind
HKD3_k127_3695809_16	1961.JOAK01000027_gene2512	2.238e-18	87.0	2E3SC@1|root,32YPX@2|Bacteria,2GQRK@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF1059)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1059
HKD3_k127_3695809_10	240016.ABIZ01000001_gene654	6.804e-70	247.0	COG0583@1|root,COG0583@2|Bacteria,46V15@74201|Verrucomicrobia,2IUGE@203494|Verrucomicrobiae	203494|Verrucomicrobiae	K	LysR substrate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HKD3_k127_3695809_0	1403819.BATR01000055_gene1732	1.282e-250	805.0	COG5373@1|root,COG5373@2|Bacteria,46S9T@74201|Verrucomicrobia,2IUWT@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Predicted membrane protein (DUF2339)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2339
HKD3_k127_3695809_11	530564.Psta_0152	4.977e-48	183.0	COG1073@1|root,COG1073@2|Bacteria	2|Bacteria	S	thiolester hydrolase activity	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Abhydrolase_1,Abhydrolase_3,Abhydrolase_6,HIT,Hydrolase_4
HKD3_k127_3695809_18	1123504.JQKD01000006_gene1535	5.853e-15	82.0	29CEM@1|root,2ZZD2@2|Bacteria,1RB3W@1224|Proteobacteria,2VT9S@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_3695809_1	1403819.BATR01000057_gene1776	5.112e-113	375.0	COG0673@1|root,COG0673@2|Bacteria,46TQ2@74201|Verrucomicrobia,2IVP0@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
HKD3_k127_3695809_14	497964.CfE428DRAFT_2885	5.813e-28	115.0	COG0227@1|root,COG0227@2|Bacteria,46TBF@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Belongs to the bacterial ribosomal protein bL28 family	rpmB	-	-	ko:K02902	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L28
HKD3_k127_3695809_9	497964.CfE428DRAFT_1900	8.238e-71	258.0	2F6YF@1|root,33ZEH@2|Bacteria,46VWD@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_3695809_13	481448.Minf_0431	5.968e-31	123.0	COG0236@1|root,COG0236@2|Bacteria,46T18@74201|Verrucomicrobia,37GVN@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	acpP	-	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
HKD3_k127_3695809_8	1288963.ADIS_4509	2.554e-72	257.0	COG3264@1|root,COG3264@2|Bacteria,4NEAM@976|Bacteroidetes,47PIS@768503|Cytophagia	976|Bacteroidetes	M	Small-conductance mechanosensitive channel	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel
HKD3_k127_3695809_3	648757.Rvan_0951	3.266e-107	361.0	COG3146@1|root,COG3146@2|Bacteria,1R5A3@1224|Proteobacteria,2U4MR@28211|Alphaproteobacteria,3N8ZM@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Peptidogalycan biosysnthesis/recognition	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_6,FemAB_like
HKD3_k127_3695809_5	497964.CfE428DRAFT_1381	9.884e-88	297.0	COG0010@1|root,COG0010@2|Bacteria	2|Bacteria	E	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines	-	-	3.5.3.11	ko:K01480	ko00330,ko01100,map00330,map01100	M00133	R01157	RC00024,RC00329	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
HKD3_k127_3695809_4	1123242.JH636434_gene5244	4.081e-92	327.0	2E55N@1|root,32ZYI@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_3695809_12	1267535.KB906767_gene3139	9.418e-40	153.0	COG5478@1|root,COG5478@2|Bacteria	2|Bacteria	S	Small integral membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	Iron_permease
HKD3_k127_3695809_2	1396141.BATP01000027_gene1075	6.763e-109	383.0	COG4953@1|root,COG4953@2|Bacteria,46TMS@74201|Verrucomicrobia,2IV2J@203494|Verrucomicrobiae	203494|Verrucomicrobiae	M	Transglycosylase	-	-	-	-	-	-	-	-	-	-	-	-	Transgly,Transpeptidase
HKD3_k127_3695809_6	497964.CfE428DRAFT_0060	4.661e-83	316.0	COG2373@1|root,COG2373@2|Bacteria,46U44@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Alpha-2-Macroglobulin	-	-	-	-	-	-	-	-	-	-	-	-	A2M,A2M_N,A2M_N_2,Thiol-ester_cl
HKD3_k127_3695809_20	118161.KB235922_gene3764	8.153e-08	65.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,1FZWQ@1117|Cyanobacteria,3VJ5T@52604|Pleurocapsales	1117|Cyanobacteria	KLT	PFAM Protein kinase domain	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase,TPR_1,TPR_11,TPR_16,TPR_2,TPR_8
HKD3_k127_3695809_7	497964.CfE428DRAFT_0115	9.674e-83	281.0	COG0177@1|root,COG0177@2|Bacteria,46T2G@74201|Verrucomicrobia	74201|Verrucomicrobia	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
HKD3_k127_3695809_19	1137281.D778_01482	1.304e-11	76.0	COG3209@1|root,COG5295@1|root,COG3209@2|Bacteria,COG5295@2|Bacteria,4NJTK@976|Bacteroidetes,1HZNB@117743|Flavobacteriia	976|Bacteroidetes	UW	surface antigen	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S74
HKD3_k127_3705837_1	111781.Lepto7376_2071	2.017e-20	96.0	2E8II@1|root,332WK@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_3705837_0	335543.Sfum_0885	3.488e-50	192.0	COG3209@1|root,COG5295@1|root,COG3209@2|Bacteria,COG5295@2|Bacteria,1N4WT@1224|Proteobacteria	1224|Proteobacteria	UW	cellulase activity	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S74
HKD3_k127_3705837_2	1122605.KB893645_gene1083	5.387e-17	84.0	COG2149@1|root,COG2149@2|Bacteria,4NSIV@976|Bacteroidetes	976|Bacteroidetes	S	Domain of unknown function (DUF202)	-	-	-	ko:K00389	-	-	-	-	ko00000	-	-	-	DUF202
HKD3_k127_3715514_12	1089544.KB912942_gene4292	2.849e-55	202.0	COG1028@1|root,COG1028@2|Bacteria,2GIX2@201174|Actinobacteria	201174|Actinobacteria	IQ	Short-chain dehydrogenase reductase sdr	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HKD3_k127_3715514_5	861299.J421_0392	5.069e-100	340.0	COG1301@1|root,COG1301@2|Bacteria,1ZTDM@142182|Gemmatimonadetes	142182|Gemmatimonadetes	U	Sodium:dicarboxylate symporter family	-	-	-	-	-	-	-	-	-	-	-	-	SDF
HKD3_k127_3715514_23	1267534.KB906754_gene2771	6.412e-07	57.0	COG3115@1|root,COG3115@2|Bacteria,3Y82I@57723|Acidobacteria,2JN9R@204432|Acidobacteriia	204432|Acidobacteriia	D	Protein of unknown function (DUF3761)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3761
HKD3_k127_3715514_19	945713.IALB_0186	5.238e-16	85.0	COG4675@1|root,COG5276@1|root,COG4675@2|Bacteria,COG5276@2|Bacteria	2|Bacteria	M	tail collar domain protein	-	-	3.4.24.40	ko:K01406,ko:K21449	ko01503,map01503	-	-	-	ko00000,ko00001,ko01000,ko01002,ko02000	1.B.40.2	-	-	Collar,Phage_fiber_2
HKD3_k127_3715514_14	335543.Sfum_0885	2.127e-42	171.0	COG3209@1|root,COG5295@1|root,COG3209@2|Bacteria,COG5295@2|Bacteria,1N4WT@1224|Proteobacteria	1224|Proteobacteria	UW	cellulase activity	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S74
HKD3_k127_3715514_22	1112216.JH594434_gene43	1.309e-11	66.0	2EFZF@1|root,339RM@2|Bacteria,1Q79X@1224|Proteobacteria,2UWHC@28211|Alphaproteobacteria,2K7QX@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_3715514_16	1123508.JH636450_gene7219	3.805e-33	150.0	COG1404@1|root,COG2911@1|root,COG2931@1|root,COG3210@1|root,COG3391@1|root,COG4935@1|root,COG1404@2|Bacteria,COG2911@2|Bacteria,COG2931@2|Bacteria,COG3210@2|Bacteria,COG3391@2|Bacteria,COG4935@2|Bacteria,2IZWN@203682|Planctomycetes	203682|Planctomycetes	Q	HemY domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_3715514_20	33876.JNXY01000004_gene1576	5.396e-16	93.0	COG1404@1|root,COG3055@1|root,COG1404@2|Bacteria,COG3055@2|Bacteria,2HU5X@201174|Actinobacteria,4DBT0@85008|Micromonosporales	201174|Actinobacteria	O	Peptidase S8 and S53 subtilisin kexin sedolisin	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Cleaved_Adhesin,Kelch_1,Peptidase_S8
HKD3_k127_3715514_3	1038922.PflQ2_2171	1.214e-107	359.0	COG0350@1|root,COG2169@1|root,COG0350@2|Bacteria,COG2169@2|Bacteria,1N2YQ@1224|Proteobacteria,1RPR3@1236|Gammaproteobacteria,1YNZM@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	FL	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated	ogt	-	2.1.1.63	ko:K00567,ko:K10778	-	-	-	-	ko00000,ko01000,ko03000,ko03400	-	-	-	Ada_Zn_binding,DNA_binding_1,HTH_18,Methyltransf_1N
HKD3_k127_3715514_18	103733.JNYO01000024_gene9146	1.435e-21	100.0	29PQU@1|root,30AP1@2|Bacteria,2IFHX@201174|Actinobacteria,4E5SZ@85010|Pseudonocardiales	201174|Actinobacteria	S	Protein of unknown function (DUF1203)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1203
HKD3_k127_3715514_8	1122604.JONR01000003_gene1527	5.401e-89	303.0	COG2367@1|root,COG2367@2|Bacteria,1NMW4@1224|Proteobacteria,1RWGW@1236|Gammaproteobacteria,1X55V@135614|Xanthomonadales	135614|Xanthomonadales	V	Beta-lactamase	-	-	3.5.2.6	ko:K17836	ko00311,ko01130,ko01501,map00311,map01130,map01501	M00627,M00628	R06363	RC01499	ko00000,ko00001,ko00002,ko01000,ko01504	-	-	-	Beta-lactamase2
HKD3_k127_3715514_10	215803.DB30_0292	2.137e-66	231.0	COG2050@1|root,COG2050@2|Bacteria,1RBPE@1224|Proteobacteria,42RKY@68525|delta/epsilon subdivisions,2WNSM@28221|Deltaproteobacteria,2YXUH@29|Myxococcales	28221|Deltaproteobacteria	Q	PFAM thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
HKD3_k127_3715514_1	497964.CfE428DRAFT_5045	1.227e-164	526.0	COG0372@1|root,COG0372@2|Bacteria,46SBV@74201|Verrucomicrobia	74201|Verrucomicrobia	C	Belongs to the citrate synthase family	gltA	-	2.3.3.1,2.3.3.5	ko:K01647,ko:K01659	ko00020,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00640,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351,R00931	RC00004,RC00067,RC00406,RC02827	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
HKD3_k127_3715514_4	497964.CfE428DRAFT_5044	9.903e-106	351.0	COG2513@1|root,COG2513@2|Bacteria	2|Bacteria	G	methylisocitrate lyase activity	prpB	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006091,GO:0006113,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0015980,GO:0016042,GO:0016054,GO:0016829,GO:0016830,GO:0016833,GO:0016999,GO:0017001,GO:0017144,GO:0019541,GO:0019543,GO:0019626,GO:0019629,GO:0019752,GO:0032787,GO:0042737,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0046421,GO:0046459,GO:0046872,GO:0055114,GO:0071704,GO:0072329,GO:1901575	4.1.3.30	ko:K03417	ko00640,map00640	-	R00409	RC00286,RC00287	ko00000,ko00001,ko01000	-	-	iECNA114_1301.ECNA114_0319,iECP_1309.ECP_0407	PEP_mutase
HKD3_k127_3715514_0	497964.CfE428DRAFT_5043	2.29e-171	551.0	COG2079@1|root,COG2079@2|Bacteria,46VQ9@74201|Verrucomicrobia	74201|Verrucomicrobia	S	MmgE/PrpD family	prpD	-	4.2.1.79	ko:K01720	ko00640,map00640	-	R04424	RC01152	ko00000,ko00001,ko01000	-	-	-	MmgE_PrpD
HKD3_k127_3715514_7	497964.CfE428DRAFT_5417	1.57e-90	309.0	COG0330@1|root,COG0330@2|Bacteria,46SQ6@74201|Verrucomicrobia	74201|Verrucomicrobia	O	HflC and HflK could regulate a protease	-	-	-	ko:K04087	-	M00742	-	-	ko00000,ko00002,ko01000	-	-	-	Band_7
HKD3_k127_3715514_6	243233.MCA0313	1.727e-92	317.0	COG0330@1|root,COG0330@2|Bacteria,1MUM2@1224|Proteobacteria,1RPUE@1236|Gammaproteobacteria,1XG0I@135618|Methylococcales	135618|Methylococcales	O	HflC and HflK could encode or regulate a protease	-	-	-	ko:K04088	-	M00742	-	-	ko00000,ko00002,ko01000	-	-	-	Band_7
HKD3_k127_3715514_11	204669.Acid345_2815	5.417e-60	212.0	COG1225@1|root,COG1225@2|Bacteria,3Y4W0@57723|Acidobacteria,2JJ7A@204432|Acidobacteriia	204432|Acidobacteriia	O	Redoxin	-	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
HKD3_k127_3715514_9	1232410.KI421421_gene3792	3.082e-79	271.0	COG4420@1|root,COG4420@2|Bacteria,1RIDY@1224|Proteobacteria,42WI7@68525|delta/epsilon subdivisions,2WSAF@28221|Deltaproteobacteria,43VM2@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF1003)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1003
HKD3_k127_3715514_2	497964.CfE428DRAFT_3226	1.659e-163	525.0	COG1914@1|root,COG1914@2|Bacteria	2|Bacteria	P	metal ion transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	Nramp
HKD3_k127_3715514_15	497964.CfE428DRAFT_2313	1.754e-40	155.0	28HPC@1|root,2Z7XD@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF4337)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4337
HKD3_k127_3715514_21	1123242.JH636437_gene6098	4.255e-14	78.0	COG0861@1|root,COG0861@2|Bacteria	2|Bacteria	P	Integral membrane protein TerC family	-	-	-	-	-	-	-	-	-	-	-	-	PGPGW
HKD3_k127_3715514_13	469383.Cwoe_1098	2.869e-45	169.0	COG4119@1|root,COG4119@2|Bacteria,2IM6D@201174|Actinobacteria,4CTE0@84995|Rubrobacteria	84995|Rubrobacteria	L	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
HKD3_k127_3779780_0	497964.CfE428DRAFT_4667	2.118e-198	625.0	COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,46S5K@74201|Verrucomicrobia	74201|Verrucomicrobia	H	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate	ribB	-	3.5.4.25,4.1.99.12	ko:K14652	ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110	M00125,M00840	R00425,R07281	RC00293,RC01792,RC01815,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	-	DHBP_synthase,GTP_cyclohydro2
HKD3_k127_3779780_19	497964.CfE428DRAFT_4666	4.403e-42	159.0	COG0054@1|root,COG0054@2|Bacteria,46T5S@74201|Verrucomicrobia	74201|Verrucomicrobia	H	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin	ribH	-	2.5.1.78	ko:K00794	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R04457	RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	DMRL_synthase
HKD3_k127_3779780_21	497964.CfE428DRAFT_4665	6.939e-39	149.0	COG0781@1|root,COG0781@2|Bacteria,46T7V@74201|Verrucomicrobia	74201|Verrucomicrobia	K	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons	nusB	-	-	ko:K03625	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	NusB
HKD3_k127_3779780_9	1396418.BATQ01000098_gene6002	4.668e-94	317.0	COG0552@1|root,COG0552@2|Bacteria,46SKC@74201|Verrucomicrobia,2ITIZ@203494|Verrucomicrobiae	203494|Verrucomicrobiae	U	SRP54-type protein, GTPase domain	-	-	-	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2,3.A.5.7	-	-	SRP54,SRP54_N
HKD3_k127_3779780_3	497964.CfE428DRAFT_3452	4.588e-152	495.0	COG3104@1|root,COG3104@2|Bacteria,46VMC@74201|Verrucomicrobia	74201|Verrucomicrobia	E	PFAM major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD3_k127_3779780_15	1265505.ATUG01000001_gene3622	2.348e-63	223.0	COG0225@1|root,COG0229@1|root,COG0225@2|Bacteria,COG0229@2|Bacteria,1RGWC@1224|Proteobacteria,42N4Z@68525|delta/epsilon subdivisions,2WIKW@28221|Deltaproteobacteria,2MHKB@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	msrA	-	1.8.4.11,1.8.4.12	ko:K07305,ko:K12267	-	-	-	-	ko00000,ko01000	-	-	-	PMSR,SelR
HKD3_k127_3779780_12	497964.CfE428DRAFT_0878	4.146e-69	238.0	2CNXM@1|root,32SI1@2|Bacteria,46SZC@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_3779780_16	448385.sce7303	6.632e-63	233.0	COG0644@1|root,COG0644@2|Bacteria,1MZVI@1224|Proteobacteria,43ENH@68525|delta/epsilon subdivisions,2X242@28221|Deltaproteobacteria,2Z170@29|Myxococcales	28221|Deltaproteobacteria	C	Tryptophan halogenase	-	-	-	-	-	-	-	-	-	-	-	-	Trp_halogenase
HKD3_k127_3779780_4	395964.KE386496_gene1205	1.321e-138	446.0	COG0657@1|root,COG0657@2|Bacteria,1RD8A@1224|Proteobacteria,2U1B8@28211|Alphaproteobacteria,3NBQ4@45404|Beijerinckiaceae	28211|Alphaproteobacteria	I	PFAM Alpha beta hydrolase fold-3 domain protein	-	-	3.1.1.83	ko:K14731	ko00903,ko00930,ko01220,map00903,map00930,map01220	-	R03751,R06390,R06391,R06392,R06393	RC00713,RC00983,RC01505	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_3
HKD3_k127_3779780_5	1448389.BAVQ01000002_gene2942	6.627e-129	438.0	COG1233@1|root,COG1233@2|Bacteria,2GJ80@201174|Actinobacteria	201174|Actinobacteria	Q	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase,NAD_binding_8
HKD3_k127_3779780_8	497964.CfE428DRAFT_4829	6.125e-103	340.0	COG0767@1|root,COG0767@2|Bacteria,46SY3@74201|Verrucomicrobia	74201|Verrucomicrobia	Q	Belongs to the MlaE permease family	-	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE
HKD3_k127_3779780_6	497964.CfE428DRAFT_4828	3.372e-105	348.0	COG1127@1|root,COG1127@2|Bacteria,46V71@74201|Verrucomicrobia	74201|Verrucomicrobia	Q	PFAM ABC transporter related	-	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
HKD3_k127_3779780_13	497964.CfE428DRAFT_4827	1.639e-68	246.0	COG1463@1|root,COG1463@2|Bacteria	2|Bacteria	Q	ABC-type transport system involved in resistance to organic solvents, periplasmic component	-	-	-	ko:K02067	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaD,OmpA
HKD3_k127_3779780_24	686340.Metal_0931	2.804e-20	108.0	COG1404@1|root,COG1404@2|Bacteria,1MU3S@1224|Proteobacteria,1RNB8@1236|Gammaproteobacteria,1XFQY@135618|Methylococcales	135618|Methylococcales	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
HKD3_k127_3779780_26	1121272.KB903255_gene5680	9.02e-15	89.0	COG1404@1|root,COG1404@2|Bacteria,2I61R@201174|Actinobacteria,4DBU1@85008|Micromonosporales	201174|Actinobacteria	GO	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Peptidase_S8
HKD3_k127_3779780_25	314230.DSM3645_05735	1.726e-15	92.0	COG1404@1|root,COG4935@1|root,COG1404@2|Bacteria,COG4935@2|Bacteria,2IY4U@203682|Planctomycetes	203682|Planctomycetes	O	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	P_proprotein,Peptidase_S8
HKD3_k127_3779780_14	497964.CfE428DRAFT_4728	3.07e-64	228.0	COG0463@1|root,COG0463@2|Bacteria,46UW3@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HKD3_k127_3779780_2	497964.CfE428DRAFT_4730	9.479e-154	489.0	COG0320@1|root,COG0320@2|Bacteria,46TZG@74201|Verrucomicrobia	74201|Verrucomicrobia	H	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives	lipA	-	2.8.1.8	ko:K03644	ko00785,ko01100,map00785,map01100	-	R07767,R07768	RC01978	ko00000,ko00001,ko01000	-	-	-	LIAS_N,Radical_SAM
HKD3_k127_3779780_11	497964.CfE428DRAFT_3446	2.768e-78	266.0	COG0353@1|root,COG0353@2|Bacteria,46SU3@74201|Verrucomicrobia	74201|Verrucomicrobia	L	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO	recR	-	-	ko:K06187	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecR,Toprim,Toprim_4
HKD3_k127_3779780_18	497964.CfE428DRAFT_3445	9.061e-48	187.0	COG2114@1|root,COG2114@2|Bacteria,46VIM@74201|Verrucomicrobia	74201|Verrucomicrobia	T	Pfam Adenylate and Guanylate cyclase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_3779780_1	240016.ABIZ01000001_gene4007	6.48e-169	546.0	COG1219@1|root,COG1219@2|Bacteria,46U7E@74201|Verrucomicrobia,2IVDM@203494|Verrucomicrobiae	203494|Verrucomicrobiae	O	AAA domain (Cdc48 subfamily)	-	-	-	-	-	-	-	-	-	-	-	-	AAA_2,ClpB_D2-small
HKD3_k127_3779780_10	497964.CfE428DRAFT_1651	6.814e-87	297.0	COG0515@1|root,COG0515@2|Bacteria,46TX9@74201|Verrucomicrobia	74201|Verrucomicrobia	KLT	Protein tyrosine kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase,RicinB_lectin_2
HKD3_k127_3779780_7	497964.CfE428DRAFT_0417	2.456e-103	344.0	COG0564@1|root,COG0564@2|Bacteria,46SQY@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Responsible for synthesis of pseudouridine from uracil	-	-	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
HKD3_k127_3779780_20	555779.Dthio_PD0143	3.736e-40	154.0	2DPSP@1|root,33387@2|Bacteria	2|Bacteria	S	23S rRNA-intervening sequence protein	-	-	-	-	-	-	-	-	-	-	-	-	23S_rRNA_IVP
HKD3_k127_3779780_22	323097.Nham_0849	4.119e-38	148.0	COG2030@1|root,COG2030@2|Bacteria,1RGUP@1224|Proteobacteria,2UAYB@28211|Alphaproteobacteria,3JU65@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	N-terminal half of MaoC dehydratase	MA20_26800	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydratas
HKD3_k127_3779780_17	497964.CfE428DRAFT_0698	1.012e-48	179.0	COG3558@1|root,COG3558@2|Bacteria,46T07@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Domain of unknown function (DUF5069)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5069
HKD3_k127_3779780_23	497964.CfE428DRAFT_6690	6.667e-31	124.0	COG2154@1|root,COG2154@2|Bacteria,46TB8@74201|Verrucomicrobia	74201|Verrucomicrobia	H	Pterin 4 alpha carbinolamine dehydratase	-	-	4.2.1.96	ko:K01724	ko00790,map00790	-	R04734	RC01208	ko00000,ko00001,ko01000,ko04147	-	-	-	Pterin_4a
HKD3_k127_3812100_29	497964.CfE428DRAFT_2215	7.122e-21	96.0	COG1524@1|root,COG1524@2|Bacteria	2|Bacteria	S	mannose-ethanolamine phosphotransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
HKD3_k127_3812100_2	478741.JAFS01000002_gene116	2.661e-197	629.0	COG1190@1|root,COG1190@2|Bacteria,46TIA@74201|Verrucomicrobia,37FUW@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	J	tRNA synthetases class II (D, K and N)	lysS	-	6.1.1.6	ko:K04567	ko00970,map00970	M00359,M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
HKD3_k127_3812100_22	497964.CfE428DRAFT_0824	2.834e-40	155.0	COG4747@1|root,COG4747@2|Bacteria,46SXP@74201|Verrucomicrobia	74201|Verrucomicrobia	S	ACT domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_3812100_25	497964.CfE428DRAFT_0076	1.272e-31	138.0	COG0457@1|root,COG0457@2|Bacteria,46TAX@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_3812100_16	497964.CfE428DRAFT_0074	3.425e-51	197.0	2EV5U@1|root,33NKM@2|Bacteria,46WDA@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_3812100_24	1123070.KB899264_gene1811	1.87e-38	155.0	COG0860@1|root,COG0860@2|Bacteria,46VNJ@74201|Verrucomicrobia,2IUFY@203494|Verrucomicrobiae	203494|Verrucomicrobiae	M	Ami_3	-	-	-	-	-	-	-	-	-	-	-	-	Amidase_3
HKD3_k127_3812100_5	497964.CfE428DRAFT_3694	1.28e-142	469.0	COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,46S7Z@74201|Verrucomicrobia	74201|Verrucomicrobia	G	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	-	4.2.1.136,5.1.99.6	ko:K17758,ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	Carb_kinase,YjeF_N
HKD3_k127_3812100_8	1121957.ATVL01000011_gene3937	1.019e-132	437.0	COG0654@1|root,COG0654@2|Bacteria,4NGIU@976|Bacteroidetes,47KM9@768503|Cytophagia	976|Bacteroidetes	H	Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid	kmo	-	1.14.13.9	ko:K00486	ko00380,ko01100,map00380,map01100	M00038	R01960	RC00046	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_3
HKD3_k127_3812100_15	497964.CfE428DRAFT_2418	2.383e-62	220.0	2DHFW@1|root,2ZZKM@2|Bacteria,46SNY@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	phyH	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_3812100_9	324602.Caur_2349	8.472e-126	416.0	COG4638@1|root,COG4638@2|Bacteria,2G720@200795|Chloroflexi,377BT@32061|Chloroflexia	32061|Chloroflexia	P	PFAM Rieske 2Fe-2S domain protein	-	-	1.14.15.7	ko:K00479,ko:K00499	ko00260,map00260	-	R07409	RC00087	ko00000,ko00001,ko01000	-	-	-	Rieske,Ring_hydroxyl_A
HKD3_k127_3812100_10	1210884.HG799476_gene15392	3.122e-111	365.0	COG3483@1|root,COG3483@2|Bacteria,2J412@203682|Planctomycetes	203682|Planctomycetes	E	Tryptophan 2,3-dioxygenase	-	-	1.13.11.11	ko:K00453	ko00380,ko01100,map00380,map01100	M00038	R00678	RC00356	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_dioxygenase
HKD3_k127_3812100_6	643867.Ftrac_2833	2.625e-136	442.0	COG2159@1|root,COG2159@2|Bacteria,4NIGJ@976|Bacteroidetes,47KJH@768503|Cytophagia	976|Bacteroidetes	S	Amidohydrolase	-	-	4.1.1.45	ko:K03392	ko00380,ko01100,map00380,map01100	M00038	R04323	RC00779	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_2
HKD3_k127_3812100_17	1120966.AUBU01000006_gene3289	3.098e-50	184.0	COG0662@1|root,COG0662@2|Bacteria,4NFU2@976|Bacteroidetes,47PIW@768503|Cytophagia	976|Bacteroidetes	G	Catalyzes the oxidative ring opening of 3- hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate	nbaC	-	1.13.11.6	ko:K00452	ko00380,ko01100,map00380,map01100	M00038	R02665	RC00387	ko00000,ko00001,ko00002,ko01000	-	-	-	3-HAO
HKD3_k127_3812100_18	240016.ABIZ01000001_gene3445	1.052e-48	180.0	COG1376@1|root,COG1376@2|Bacteria,46VEG@74201|Verrucomicrobia,2IUCV@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	L,D-transpeptidase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	YkuD
HKD3_k127_3812100_3	497964.CfE428DRAFT_3353	1.701e-163	523.0	COG0476@1|root,COG0607@1|root,COG0476@2|Bacteria,COG0607@2|Bacteria,46SGF@74201|Verrucomicrobia	74201|Verrucomicrobia	H	UBA THIF-type NAD FAD binding protein	thiF	-	2.7.7.80,2.8.1.11	ko:K21147	ko04122,map04122	-	R07459,R07461	RC00043	ko00000,ko00001,ko01000	-	-	-	Rhodanese,ThiF
HKD3_k127_3812100_19	497964.CfE428DRAFT_3624	2.395e-45	173.0	COG1652@1|root,COG1652@2|Bacteria,46T8E@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Lysin motif	-	-	-	-	-	-	-	-	-	-	-	-	LysM
HKD3_k127_3812100_13	497964.CfE428DRAFT_4603	5.194e-93	320.0	COG0349@1|root,COG0349@2|Bacteria,46SUU@74201|Verrucomicrobia	74201|Verrucomicrobia	L	3'-5' exonuclease	rnd	-	3.1.13.5	ko:K03684	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DNA_pol_A_exo1,HRDC
HKD3_k127_3812100_4	1403819.BATR01000002_gene65	7.492e-149	484.0	COG1158@1|root,COG1158@2|Bacteria,46S5Y@74201|Verrucomicrobia,2ITR1@203494|Verrucomicrobiae	203494|Verrucomicrobiae	K	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template	-	-	-	ko:K03628	ko03018,map03018	-	-	-	ko00000,ko00001,ko03019,ko03021	-	-	-	ATP-synt_ab,Rho_RNA_bind
HKD3_k127_3812100_26	1396141.BATP01000025_gene896	3.652e-31	130.0	COG1158@1|root,COG1158@2|Bacteria,46S5Y@74201|Verrucomicrobia,2ITR1@203494|Verrucomicrobiae	203494|Verrucomicrobiae	K	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template	-	-	-	ko:K03628	ko03018,map03018	-	-	-	ko00000,ko00001,ko03019,ko03021	-	-	-	ATP-synt_ab,Rho_RNA_bind
HKD3_k127_3812100_0	661478.OP10G_1347	1.717e-254	814.0	COG4447@1|root,COG4447@2|Bacteria	2|Bacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	BNR,Sortilin-Vps10
HKD3_k127_3812100_14	478741.JAFS01000001_gene1899	1.054e-88	299.0	COG0623@1|root,COG0623@2|Bacteria,46UJB@74201|Verrucomicrobia,37G8S@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	I	Enoyl-(Acyl carrier protein) reductase	fabI	-	1.3.1.10,1.3.1.9	ko:K00208	ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212	M00083,M00572	R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671	RC00052,RC00076,RC00120	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HKD3_k127_3812100_27	309807.SRU_2716	9.674e-25	106.0	COG2329@1|root,COG2329@2|Bacteria,4NW7R@976|Bacteroidetes	976|Bacteroidetes	S	Antibiotic biosynthesis monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_3812100_1	497964.CfE428DRAFT_0079	4.625e-209	662.0	COG0277@1|root,COG0277@2|Bacteria,46SFA@74201|Verrucomicrobia	74201|Verrucomicrobia	C	FAD linked oxidases, C-terminal domain	-	-	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
HKD3_k127_3812100_12	497964.CfE428DRAFT_0354	1.357e-95	322.0	COG3868@1|root,COG3868@2|Bacteria,46STS@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Glycoside-hydrolase family GH114	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_3812100_23	497964.CfE428DRAFT_0629	7.621e-40	152.0	COG1359@1|root,COG1359@2|Bacteria	2|Bacteria	S	Antibiotic biosynthesis monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	ABM,EthD
HKD3_k127_3812100_7	492774.JQMB01000007_gene4175	1.823e-133	447.0	COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,4B9BA@82115|Rhizobiaceae	1224|Proteobacteria	T	Adenylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,TPR_2,TPR_8,Trans_reg_C
HKD3_k127_3812100_31	909663.KI867150_gene972	1.608e-12	74.0	2CIE9@1|root,32S7U@2|Bacteria,1P112@1224|Proteobacteria,431TX@68525|delta/epsilon subdivisions,2WWP3@28221|Deltaproteobacteria,2MS3R@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF4404)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4404
HKD3_k127_3812100_20	204669.Acid345_1452	1.291e-41	158.0	2DTV5@1|root,33MT0@2|Bacteria,3Y5UW@57723|Acidobacteria,2JNBS@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_3812100_28	497964.CfE428DRAFT_3464	1.072e-22	108.0	COG4249@1|root,COG4249@2|Bacteria,46WW5@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Putative peptidoglycan binding domain	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_1
HKD3_k127_3812100_30	1254432.SCE1572_04230	3.078e-13	78.0	COG0526@1|root,COG0526@2|Bacteria	2|Bacteria	CO	cell redox homeostasis	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,SBP_bac_10,Thioredoxin
HKD3_k127_3812100_21	450851.PHZ_c0831	1.276e-40	163.0	COG4977@1|root,COG4977@2|Bacteria,1PFG6@1224|Proteobacteria,2V7GC@28211|Alphaproteobacteria,2KJ6G@204458|Caulobacterales	204458|Caulobacterales	K	DJ-1/PfpI family	-	-	-	-	-	-	-	-	-	-	-	-	DJ-1_PfpI
HKD3_k127_3812100_11	886293.Sinac_4113	1.225e-101	341.0	COG4977@1|root,COG4977@2|Bacteria,2IXH9@203682|Planctomycetes	203682|Planctomycetes	K	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain	-	-	-	ko:K17736	-	-	-	-	ko00000,ko03000	-	-	-	DJ-1_PfpI,HTH_18
HKD3_k127_3834704_2	497964.CfE428DRAFT_4653	1.106e-44	162.0	COG1199@1|root,COG1199@2|Bacteria,46SCS@74201|Verrucomicrobia	74201|Verrucomicrobia	L	SMART helicase c2	dinG	-	3.6.4.12	ko:K03722	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_2,Helicase_C_2,ResIII
HKD3_k127_3834704_1	497964.CfE428DRAFT_6154	5.501e-78	273.0	COG0389@1|root,COG0389@2|Bacteria,46SR8@74201|Verrucomicrobia	74201|Verrucomicrobia	L	impB/mucB/samB family	-	-	-	ko:K14161	-	-	-	-	ko00000,ko03400	-	-	-	IMS,IMS_C
HKD3_k127_3834704_0	583355.Caka_0128	0.0	1077.0	COG0587@1|root,COG0587@2|Bacteria,46S6W@74201|Verrucomicrobia,3K9E1@414999|Opitutae	414999|Opitutae	L	Belongs to the DNA polymerase type-C family. DnaE2 subfamily	-	-	2.7.7.7	ko:K14162	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP
HKD3_k127_3834704_3	1267534.KB906754_gene2652	1.078e-43	161.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,3Y3X0@57723|Acidobacteria,2JIZ1@204432|Acidobacteriia	204432|Acidobacteriia	EU	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
HKD3_k127_3851474_2	1192034.CAP_4903	0.0004035	45.0	COG3055@1|root,COG3055@2|Bacteria	2|Bacteria	G	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses	-	-	-	-	-	-	-	-	-	-	-	-	Kelch_4
HKD3_k127_3851474_0	234267.Acid_0813	4.815e-148	477.0	COG0436@1|root,COG0436@2|Bacteria,3Y5AV@57723|Acidobacteria	57723|Acidobacteria	E	aminotransferase class I and II	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
HKD3_k127_3851474_1	234267.Acid_0814	2.983e-105	349.0	COG0531@1|root,COG0531@2|Bacteria	2|Bacteria	E	amino acid	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
HKD3_k127_3851691_10	1123073.KB899241_gene3395	2.621e-44	164.0	COG0624@1|root,COG0624@2|Bacteria,1R96A@1224|Proteobacteria,1RSD6@1236|Gammaproteobacteria,1X5K9@135614|Xanthomonadales	135614|Xanthomonadales	E	Peptidase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
HKD3_k127_3851691_1	1125863.JAFN01000001_gene3390	3.874e-187	609.0	COG0417@1|root,COG0417@2|Bacteria,1MVY9@1224|Proteobacteria,42Q4K@68525|delta/epsilon subdivisions,2WKQ1@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	DNA polymerase type-B family	polB	-	2.7.7.7	ko:K02336	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_pol_B,DNA_pol_B_exo1,RNase_H_2
HKD3_k127_3851691_3	215803.DB30_3749	1.313e-140	460.0	COG1473@1|root,COG1473@2|Bacteria,1MUIV@1224|Proteobacteria,42NR8@68525|delta/epsilon subdivisions,2WM9T@28221|Deltaproteobacteria,2YXV5@29|Myxococcales	28221|Deltaproteobacteria	M	Peptidase dimerisation domain	-	-	-	ko:K01436	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20
HKD3_k127_3851691_4	497964.CfE428DRAFT_2927	5.065e-134	441.0	COG0206@1|root,COG0206@2|Bacteria,46UWD@74201|Verrucomicrobia	74201|Verrucomicrobia	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
HKD3_k127_3851691_2	497964.CfE428DRAFT_2928	9.088e-185	584.0	COG0849@1|root,COG0849@2|Bacteria,46SQI@74201|Verrucomicrobia	74201|Verrucomicrobia	D	Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring	ftsA	-	-	ko:K03590	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036,ko04812	-	-	-	FtsA,SHS2_FTSA
HKD3_k127_3851691_9	497964.CfE428DRAFT_2929	1.771e-73	265.0	COG1589@1|root,COG1589@2|Bacteria,46T4T@74201|Verrucomicrobia	74201|Verrucomicrobia	D	Cell division protein FtsQ	ftsQ	-	-	ko:K03589	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036	-	-	-	FtsQ,POTRA_1
HKD3_k127_3851691_7	497964.CfE428DRAFT_2930	2.89e-116	383.0	COG1181@1|root,COG1181@2|Bacteria,46UZ2@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Belongs to the D-alanine--D-alanine ligase family	ddl	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C,Dala_Dala_lig_N
HKD3_k127_3851691_0	497964.CfE428DRAFT_2932	2.631e-295	925.0	COG0773@1|root,COG0812@1|root,COG0773@2|Bacteria,COG0812@2|Bacteria,46SCG@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Cell wall formation	murB	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_4,MurB_C,Mur_ligase,Mur_ligase_C,Mur_ligase_M
HKD3_k127_3851691_6	497964.CfE428DRAFT_2933	6.413e-122	401.0	COG0707@1|root,COG0707@2|Bacteria,46S84@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)	murG	-	2.4.1.227	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	-	R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011	-	GT28	-	Glyco_tran_28_C,Glyco_transf_28
HKD3_k127_3851691_8	1396418.BATQ01000080_gene767	4.611e-98	332.0	COG0772@1|root,COG0772@2|Bacteria,46SMC@74201|Verrucomicrobia,2ITN2@203494|Verrucomicrobiae	203494|Verrucomicrobiae	D	Cell cycle protein	-	-	-	ko:K03588	ko04112,map04112	-	-	-	ko00000,ko00001,ko02000,ko03036	2.A.103.1	-	-	FTSW_RODA_SPOVE
HKD3_k127_3851691_11	497964.CfE428DRAFT_2935	8.715e-12	74.0	COG1388@1|root,COG1388@2|Bacteria,46T90@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Lysin motif	-	-	-	-	-	-	-	-	-	-	-	-	LysM
HKD3_k127_3851691_5	497964.CfE428DRAFT_2936	1.266e-128	419.0	COG0771@1|root,COG0771@2|Bacteria,46UUH@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)	murD	-	6.3.2.9	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R02783	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase_C,Mur_ligase_M
HKD3_k127_3854837_20	204669.Acid345_2293	9.374e-67	239.0	COG3301@1|root,COG3301@2|Bacteria,3Y506@57723|Acidobacteria,2JN1H@204432|Acidobacteriia	204432|Acidobacteriia	P	Polysulphide reductase, NrfD	-	-	-	-	-	-	-	-	-	-	-	-	NrfD
HKD3_k127_3854837_11	404380.Gbem_2180	1.7e-97	328.0	COG0437@1|root,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,42RAW@68525|delta/epsilon subdivisions,2WMX4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	-	-	-	ko:K00124	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001	-	-	-	Fer4_11,Fer4_3,Fer4_4
HKD3_k127_3854837_0	204669.Acid345_2291	0.0	1050.0	COG0243@1|root,COG3383@1|root,COG0243@2|Bacteria,COG3383@2|Bacteria,3Y47M@57723|Acidobacteria,2JKQK@204432|Acidobacteriia	204432|Acidobacteriia	C	Molydopterin dinucleotide binding domain	-	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Molybdopterin,Molydop_binding
HKD3_k127_3854837_16	204669.Acid345_2290	1.511e-74	255.0	COG3383@1|root,COG3383@2|Bacteria	2|Bacteria	C	formate dehydrogenase (NAD+) activity	-	-	-	-	-	-	-	-	-	-	-	iHN637.CLJU_RS03470	Fer2_4,Fer4,Fer4_21,Fer4_7
HKD3_k127_3854837_23	497964.CfE428DRAFT_3333	2.38e-58	218.0	COG1565@1|root,COG1565@2|Bacteria,46T7F@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Putative S-adenosyl-L-methionine-dependent methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_28
HKD3_k127_3854837_3	240016.ABIZ01000001_gene401	9.606e-195	637.0	COG0744@1|root,COG0744@2|Bacteria,46TMG@74201|Verrucomicrobia,2ITVY@203494|Verrucomicrobiae	203494|Verrucomicrobiae	M	Transglycosylase	-	-	-	-	-	-	-	-	-	-	-	-	Transgly,Transpeptidase
HKD3_k127_3854837_13	497964.CfE428DRAFT_3746	1.979e-86	297.0	2F3W6@1|root,33WND@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_3854837_5	497964.CfE428DRAFT_6327	1.212e-134	435.0	COG0517@1|root,COG0794@1|root,COG0517@2|Bacteria,COG0794@2|Bacteria,46S8G@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Belongs to the SIS family. GutQ KpsF subfamily	gutQ	-	5.3.1.13	ko:K06041	ko00540,ko01100,map00540,map01100	M00063	R01530	RC00541	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CBS,SIS
HKD3_k127_3854837_14	497964.CfE428DRAFT_3924	2.398e-84	283.0	COG0231@1|root,COG0231@2|Bacteria,46SQH@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase	efp	-	-	ko:K02356	-	-	-	-	ko00000,ko03012	-	-	-	EFP,EFP_N,Elong-fact-P_C
HKD3_k127_3854837_1	497964.CfE428DRAFT_1955	0.0	1019.0	COG3280@1|root,COG3280@2|Bacteria,46SC6@74201|Verrucomicrobia	74201|Verrucomicrobia	G	Alpha amylase, catalytic domain	treY	-	5.4.99.15	ko:K06044	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R01824,R09995	-	ko00000,ko00001,ko00002,ko01000	-	GH13	-	Alpha-amylase
HKD3_k127_3854837_2	349741.Amuc_2169	3.546e-204	653.0	COG0018@1|root,COG0018@2|Bacteria,46SH6@74201|Verrucomicrobia,2ITX2@203494|Verrucomicrobiae	203494|Verrucomicrobiae	J	Arginyl tRNA synthetase N terminal dom	argS	-	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
HKD3_k127_3854837_19	497964.CfE428DRAFT_4578	8.923e-69	237.0	COG1762@1|root,COG1762@2|Bacteria	2|Bacteria	G	phosphoenolpyruvate-dependent sugar phosphotransferase system	ptsN3	-	2.7.1.202	ko:K02768,ko:K02769,ko:K02770,ko:K02806	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	M00273	R03232	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.2.1	-	-	PTS_EIIA_2
HKD3_k127_3854837_12	497964.CfE428DRAFT_2102	1.528e-92	309.0	COG0463@1|root,COG0463@2|Bacteria,46SPS@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HKD3_k127_3854837_7	497964.CfE428DRAFT_2103	7.731e-130	432.0	COG1807@1|root,COG1807@2|Bacteria,46SSE@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PAP2,PMT_2,TPR_12
HKD3_k127_3854837_27	497964.CfE428DRAFT_2104	7.415e-41	159.0	COG0671@1|root,COG0671@2|Bacteria,46W7N@74201|Verrucomicrobia	74201|Verrucomicrobia	I	Acid phosphatase homologues	-	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2
HKD3_k127_3854837_28	497964.CfE428DRAFT_2105	1.016e-38	154.0	COG3026@1|root,COG3026@2|Bacteria,46W95@74201|Verrucomicrobia	74201|Verrucomicrobia	T	Outer membrane lipoprotein-sorting protein	-	-	-	-	-	-	-	-	-	-	-	-	LolA_like
HKD3_k127_3854837_26	497964.CfE428DRAFT_2339	5.22e-43	165.0	COG0724@1|root,COG0724@2|Bacteria,46WD6@74201|Verrucomicrobia	74201|Verrucomicrobia	S	RNA recognition motif	-	-	-	-	-	-	-	-	-	-	-	-	RRM_1
HKD3_k127_3854837_34	102129.Lepto7375DRAFT_3052	9.561e-09	66.0	COG0726@1|root,COG0726@2|Bacteria,1G6FJ@1117|Cyanobacteria,1HB8K@1150|Oscillatoriales	1117|Cyanobacteria	G	Sulfotransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_3
HKD3_k127_3854837_6	497964.CfE428DRAFT_2473	7.215e-132	427.0	COG0451@1|root,COG0451@2|Bacteria,46SJG@74201|Verrucomicrobia	74201|Verrucomicrobia	M	PFAM NAD-dependent epimerase dehydratase	-	-	5.1.3.6	ko:K08679	ko00520,ko01100,map00520,map01100	-	R01385	RC00289	ko00000,ko00001,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
HKD3_k127_3854837_25	497964.CfE428DRAFT_2652	5.673e-48	184.0	COG2881@1|root,COG5523@1|root,COG2881@2|Bacteria,COG5523@2|Bacteria	2|Bacteria	T	integral membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF4339,DUF975,Yip1
HKD3_k127_3854837_21	204669.Acid345_0702	2.58e-62	221.0	COG0122@1|root,COG0122@2|Bacteria,3Y30W@57723|Acidobacteria,2JHWW@204432|Acidobacteriia	204432|Acidobacteriia	L	endonuclease III	-	-	3.2.2.21	ko:K01247	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
HKD3_k127_3854837_10	1123368.AUIS01000019_gene1217	2.566e-101	335.0	COG2220@1|root,COG2220@2|Bacteria,1R5GU@1224|Proteobacteria,1SIPM@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Zn-dependent hydrolases of the beta-lactamase fold	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_3
HKD3_k127_3854837_17	472759.Nhal_1235	1.184e-72	258.0	COG0392@1|root,COG0392@2|Bacteria,1RCBH@1224|Proteobacteria,1S366@1236|Gammaproteobacteria,1X1IF@135613|Chromatiales	135613|Chromatiales	S	Lysylphosphatidylglycerol synthase TM region	-	-	-	-	-	-	-	-	-	-	-	-	LPG_synthase_TM
HKD3_k127_3854837_29	1500894.JQNN01000001_gene528	3.444e-26	116.0	COG0671@1|root,COG0671@2|Bacteria,1PEF1@1224|Proteobacteria,2WAMH@28216|Betaproteobacteria,477R1@75682|Oxalobacteraceae	28216|Betaproteobacteria	I	Acid phosphatase homologues	-	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2
HKD3_k127_3854837_31	338966.Ppro_0498	5.049e-13	80.0	2E6EE@1|root,3311V@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_3854837_32	7994.ENSAMXP00000003683	3.184e-12	72.0	COG1028@1|root,KOG4170@1|root,KOG0725@2759|Eukaryota,KOG4170@2759|Eukaryota,38DZE@33154|Opisthokonta,3BA0D@33208|Metazoa,3CVGY@33213|Bilateria,480GA@7711|Chordata,49406@7742|Vertebrata,49ZAM@7898|Actinopterygii	33208|Metazoa	I	Hydroxysteroid dehydrogenase like 2	HSDL2	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005777,GO:0042579,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464	-	-	-	-	-	-	-	-	-	-	SCP2,adh_short
HKD3_k127_3854837_9	497964.CfE428DRAFT_5232	6.792e-126	415.0	COG0842@1|root,COG0842@2|Bacteria,46SWI@74201|Verrucomicrobia	497964.CfE428DRAFT_5232|-	V	PFAM ABC-2 type transporter	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_3854837_8	497964.CfE428DRAFT_5231	3.814e-127	413.0	COG1131@1|root,COG1131@2|Bacteria,46SF6@74201|Verrucomicrobia	74201|Verrucomicrobia	V	PFAM ABC transporter related	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD3_k127_3854837_15	497964.CfE428DRAFT_1376	2.598e-78	274.0	2EF9S@1|root,3392N@2|Bacteria,46VYT@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_3854837_24	497964.CfE428DRAFT_1377	9.799e-52	199.0	2E6EE@1|root,3311V@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_3854837_4	497964.CfE428DRAFT_1668	9.454e-139	455.0	COG0477@1|root,COG0477@2|Bacteria	2|Bacteria	EGP	Major facilitator Superfamily	entS	-	-	ko:K08225	-	-	-	-	ko00000,ko02000	2.A.1.38	-	-	MFS_3
HKD3_k127_3854837_33	497964.CfE428DRAFT_2982	1.316e-09	64.0	COG1595@1|root,COG1595@2|Bacteria,46V3P@74201|Verrucomicrobia	74201|Verrucomicrobia	K	DNA-templated transcription, initiation	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2
HKD3_k127_3886584_0	452637.Oter_1899	5.645e-216	689.0	COG0577@1|root,COG0577@2|Bacteria,46TJI@74201|Verrucomicrobia	2|Bacteria	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HKD3_k127_3894612_15	497964.CfE428DRAFT_1048	1.811e-86	295.0	COG3757@1|root,COG3757@2|Bacteria,46WSP@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Glycosyl hydrolases family 25	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_25
HKD3_k127_3894612_5	215803.DB30_2967	5.135e-151	486.0	2C57D@1|root,2Z7RS@2|Bacteria,1MX6G@1224|Proteobacteria,42Y78@68525|delta/epsilon subdivisions,2X3CW@28221|Deltaproteobacteria,2YUS0@29|Myxococcales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF2891)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2891
HKD3_k127_3894612_9	984262.SGRA_2970	8.309e-137	446.0	COG1960@1|root,COG1960@2|Bacteria,4NEKJ@976|Bacteroidetes,1INZ7@117747|Sphingobacteriia	976|Bacteroidetes	I	acyl-CoA dehydrogenase	gcdH	-	1.3.8.6	ko:K00252	ko00071,ko00310,ko00362,ko00380,ko01100,ko01120,ko01130,map00071,map00310,map00362,map00380,map01100,map01120,map01130	M00032	R02487,R02488,R10074	RC00052,RC00156	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HKD3_k127_3894612_4	497964.CfE428DRAFT_6587	1.464e-158	509.0	COG0183@1|root,COG0183@2|Bacteria	2|Bacteria	I	Belongs to the thiolase family	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
HKD3_k127_3894612_29	634452.APA01_24950	0.0006472	48.0	COG0346@1|root,COG0346@2|Bacteria,1RH3J@1224|Proteobacteria,2U9J3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	glyoxalase bleomycin resistance protein dioxygenase	-	-	4.4.1.5	ko:K01759	ko00620,map00620	-	R02530	RC00004,RC00740	ko00000,ko00001,ko01000	-	-	-	Glyoxalase
HKD3_k127_3894612_27	1496688.ER33_14645	8.058e-28	117.0	COG0154@1|root,COG0154@2|Bacteria,1GDVJ@1117|Cyanobacteria	1117|Cyanobacteria	J	Belongs to the amidase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidase
HKD3_k127_3894612_12	1496688.ER33_14645	5.674e-114	374.0	COG0154@1|root,COG0154@2|Bacteria,1GDVJ@1117|Cyanobacteria	1117|Cyanobacteria	J	Belongs to the amidase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidase
HKD3_k127_3894612_2	1396418.BATQ01000123_gene4933	3.155e-198	627.0	COG1509@1|root,COG1509@2|Bacteria,46SVQ@74201|Verrucomicrobia,2ITNU@203494|Verrucomicrobiae	203494|Verrucomicrobiae	E	Lysine-2,3-aminomutase	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_14,LAM_C,Radical_SAM
HKD3_k127_3894612_22	497964.CfE428DRAFT_4436	2.98e-62	221.0	COG2345@1|root,COG2345@2|Bacteria,46SX5@74201|Verrucomicrobia	74201|Verrucomicrobia	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24
HKD3_k127_3894612_1	1396418.BATQ01000171_gene2965	9.742e-239	754.0	COG0366@1|root,COG0366@2|Bacteria,46S7A@74201|Verrucomicrobia	74201|Verrucomicrobia	G	Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB	glgE	-	2.4.99.16	ko:K16147	ko00500,ko01100,map00500,map01100	-	R09994	-	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,DUF3416
HKD3_k127_3894612_21	497964.CfE428DRAFT_0164	1.335e-64	231.0	COG0811@1|root,COG0811@2|Bacteria,46SY0@74201|Verrucomicrobia	74201|Verrucomicrobia	U	PFAM MotA TolQ ExbB proton channel	-	-	-	ko:K03561	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	MotA_ExbB
HKD3_k127_3894612_26	478741.JAFS01000001_gene1264	5.032e-35	138.0	COG0848@1|root,COG0848@2|Bacteria,46T1K@74201|Verrucomicrobia,37GK3@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	U	Biopolymer transport protein ExbD/TolR	-	-	-	ko:K03559	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	ExbD
HKD3_k127_3894612_6	497964.CfE428DRAFT_0166	5.581e-151	508.0	COG0457@1|root,COG1729@1|root,COG0457@2|Bacteria,COG1729@2|Bacteria,46UJD@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_6,TPR_8
HKD3_k127_3894612_28	1268622.AVS7_04721	0.0004742	44.0	COG4804@1|root,COG4804@2|Bacteria,1NBWK@1224|Proteobacteria,2VJU6@28216|Betaproteobacteria,4ACFC@80864|Comamonadaceae	28216|Betaproteobacteria	S	Protein of unknown function (DUF1016)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1016
HKD3_k127_3894612_13	452637.Oter_4136	3.463e-99	337.0	COG3391@1|root,COG3391@2|Bacteria,46WC1@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Lactonase, 7-bladed beta-propeller	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_D1,Lactonase
HKD3_k127_3894612_8	497964.CfE428DRAFT_0326	5.087e-146	470.0	COG0075@1|root,COG0075@2|Bacteria,46SCI@74201|Verrucomicrobia	74201|Verrucomicrobia	E	Aminotransferase class-V	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
HKD3_k127_3894612_7	497964.CfE428DRAFT_0801	1.918e-147	474.0	COG4586@1|root,COG4586@2|Bacteria,46TXF@74201|Verrucomicrobia	74201|Verrucomicrobia	S	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD3_k127_3894612_18	1396418.BATQ01000171_gene2946	2.558e-74	259.0	COG0451@1|root,COG0703@1|root,COG0451@2|Bacteria,COG0703@2|Bacteria,46SWG@74201|Verrucomicrobia,2IUD4@203494|Verrucomicrobiae	203494|Verrucomicrobiae	GM	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase,SKI
HKD3_k127_3894612_14	497964.CfE428DRAFT_5017	4.271e-87	294.0	COG1354@1|root,COG1354@2|Bacteria,46UBD@74201|Verrucomicrobia	74201|Verrucomicrobia	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves	-	-	-	-	-	-	-	-	-	-	-	-	SMC_ScpA
HKD3_k127_3894612_11	497964.CfE428DRAFT_0653	1.326e-127	418.0	COG0772@1|root,COG0772@2|Bacteria,46SQT@74201|Verrucomicrobia	74201|Verrucomicrobia	D	Belongs to the SEDS family	rodA	-	-	ko:K05837	-	-	-	-	ko00000,ko03036	-	-	-	FTSW_RODA_SPOVE
HKD3_k127_3894612_25	497964.CfE428DRAFT_4702	4.141e-49	179.0	COG1451@1|root,COG1451@2|Bacteria	2|Bacteria	S	Protein of unknown function DUF45	CP_0175	-	-	ko:K07043	-	-	-	-	ko00000	-	-	-	DUF45,SprT-like
HKD3_k127_3894612_17	497964.CfE428DRAFT_3031	3.704e-79	273.0	COG1624@1|root,COG1624@2|Bacteria,46SSQ@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria	dacA	-	2.7.7.85	ko:K18672	-	-	-	-	ko00000,ko01000	-	-	-	DisA_N
HKD3_k127_3894612_16	1123070.KB899255_gene1293	1.008e-82	285.0	COG0294@1|root,COG0294@2|Bacteria,46SSW@74201|Verrucomicrobia,2ITVR@203494|Verrucomicrobiae	203494|Verrucomicrobiae	H	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives	-	-	2.5.1.15	ko:K00796	ko00790,ko01100,map00790,map01100	M00126,M00841	R03066,R03067	RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
HKD3_k127_3894612_24	443143.GM18_2778	8.089e-51	186.0	COG1881@1|root,COG1881@2|Bacteria,1N0Y4@1224|Proteobacteria,42RIQ@68525|delta/epsilon subdivisions,2WNC7@28221|Deltaproteobacteria,43SKU@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Phosphatidylethanolamine-binding protein	-	-	-	ko:K06910	-	-	-	-	ko00000	-	-	-	PBP
HKD3_k127_3894612_0	497964.CfE428DRAFT_4550	4.376e-263	829.0	COG0557@1|root,COG0557@2|Bacteria,46U8T@74201|Verrucomicrobia	74201|Verrucomicrobia	K	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs	rnr	-	-	ko:K12573	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	OB_RNB,RNB,S1
HKD3_k127_3894612_10	497964.CfE428DRAFT_4918	4.705e-130	427.0	COG0369@1|root,COG0369@2|Bacteria,46SEE@74201|Verrucomicrobia	74201|Verrucomicrobia	P	oxidoreductase FAD NAD(P)-binding domain protein	-	-	1.8.1.2	ko:K00380	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00176	R00858	RC00065	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_1,Flavodoxin_1,NAD_binding_1
HKD3_k127_3894612_19	497964.CfE428DRAFT_0259	2.182e-67	233.0	COG2151@1|root,COG2151@2|Bacteria,46SWX@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Pfam:DUF59	-	-	-	-	-	-	-	-	-	-	-	-	FeS_assembly_P
HKD3_k127_3894612_23	497964.CfE428DRAFT_6470	9.081e-58	206.0	COG0359@1|root,COG0359@2|Bacteria,46SYE@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Binds to the 23S rRNA	rplI	-	-	ko:K02939	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L9_C,Ribosomal_L9_N
HKD3_k127_3894612_3	497964.CfE428DRAFT_6469	7.877e-176	564.0	COG0305@1|root,COG0305@2|Bacteria,46SKM@74201|Verrucomicrobia	74201|Verrucomicrobia	L	Participates in initiation and elongation during chromosome replication	dnaB	-	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C
HKD3_k127_3894612_20	1396141.BATP01000034_gene4169	8.383e-67	230.0	COG0021@1|root,COG0021@2|Bacteria,46SHW@74201|Verrucomicrobia,2ITKK@203494|Verrucomicrobiae	203494|Verrucomicrobiae	G	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
HKD3_k127_3898841_9	331678.Cphamn1_2403	3.735e-09	58.0	COG1917@1|root,COG1917@2|Bacteria	2|Bacteria	L	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HKD3_k127_3898841_3	1267533.KB906735_gene4847	2.469e-148	485.0	COG1807@1|root,COG1807@2|Bacteria	2|Bacteria	M	4-amino-4-deoxy-L-arabinose transferase activity	MA20_19960	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HKD3_k127_3898841_7	497964.CfE428DRAFT_2573	3.269e-31	129.0	COG1186@1|root,COG1186@2|Bacteria,46T84@74201|Verrucomicrobia	74201|Verrucomicrobia	J	RF-1 domain	-	-	-	-	-	-	-	-	-	-	-	-	RF-1
HKD3_k127_3898841_0	497964.CfE428DRAFT_4373	0.0	1244.0	COG0188@1|root,COG0188@2|Bacteria,46SBE@74201|Verrucomicrobia	74201|Verrucomicrobia	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
HKD3_k127_3898841_8	290400.Jann_2787	1.797e-24	113.0	COG4424@1|root,COG4424@2|Bacteria,1RBDG@1224|Proteobacteria,2U6M2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Stf0 sulphotransferase	-	-	2.8.2.37	ko:K21014	-	-	-	-	ko00000,ko01000	-	-	-	Sulphotransf
HKD3_k127_3898841_1	497964.CfE428DRAFT_4376	0.0	1106.0	COG0187@1|root,COG0187@2|Bacteria,46SDH@74201|Verrucomicrobia	74201|Verrucomicrobia	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
HKD3_k127_3898841_6	497964.CfE428DRAFT_0262	1.496e-74	256.0	COG0688@1|root,COG0688@2|Bacteria,46VRI@74201|Verrucomicrobia	74201|Verrucomicrobia	I	Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer)	psd	-	4.1.1.65	ko:K01613	ko00564,ko01100,ko01110,map00564,map01100,map01110	M00093	R02055	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	PS_Dcarbxylase
HKD3_k127_3898841_4	497964.CfE428DRAFT_0263	6.192e-111	364.0	COG1183@1|root,COG1183@2|Bacteria,46SK0@74201|Verrucomicrobia	74201|Verrucomicrobia	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pssA	-	2.7.8.8	ko:K17103	ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110	M00093	R01800	RC00002,RC00017,RC02795	ko00000,ko00001,ko00002,ko01000	-	-	-	CDP-OH_P_transf
HKD3_k127_3898841_5	497964.CfE428DRAFT_2729	5.837e-103	340.0	COG1209@1|root,COG1209@2|Bacteria,46T9Q@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Nucleotidyl transferase	-	-	2.3.1.157,2.7.7.23	ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
HKD3_k127_3898841_2	204669.Acid345_2533	1.982e-190	608.0	COG4447@1|root,COG4447@2|Bacteria,3Y69Z@57723|Acidobacteria	57723|Acidobacteria	S	Sortilin, neurotensin receptor 3,	-	-	-	-	-	-	-	-	-	-	-	-	Sortilin-Vps10
HKD3_k127_3936482_0	172088.AUGA01000021_gene5211	9.254e-131	431.0	COG0428@1|root,COG0664@1|root,COG0428@2|Bacteria,COG0664@2|Bacteria	2|Bacteria	T	cyclic nucleotide binding	-	-	-	ko:K07238	-	-	-	-	ko00000,ko02000	2.A.5.5	-	-	cNMP_binding
HKD3_k127_4038937_42	555779.Dthio_PD0754	8.615e-19	86.0	2AFHA@1|root,315HT@2|Bacteria,1N31Y@1224|Proteobacteria,43DNR@68525|delta/epsilon subdivisions,2X6MU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	23S rRNA-intervening sequence protein	-	-	-	-	-	-	-	-	-	-	-	-	23S_rRNA_IVP
HKD3_k127_4038937_20	314345.SPV1_00492	9.622e-75	254.0	COG0110@1|root,COG0110@2|Bacteria,1R6A3@1224|Proteobacteria	1224|Proteobacteria	S	acetyltransferase, isoleucine patch superfamily	wcaF	GO:0003674,GO:0003824,GO:0008374,GO:0016740,GO:0016746,GO:0016747	-	ko:K03818	-	-	-	-	ko00000,ko01000	-	-	-	Hexapep,Hexapep_2
HKD3_k127_4038937_9	452637.Oter_2749	3.806e-110	363.0	COG0463@1|root,COG0463@2|Bacteria,46U7T@74201|Verrucomicrobia,3K8I1@414999|Opitutae	414999|Opitutae	M	PFAM glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HKD3_k127_4038937_36	626418.bglu_2g20080	5.813e-28	115.0	COG5470@1|root,COG5470@2|Bacteria,1N7JA@1224|Proteobacteria,2VU5B@28216|Betaproteobacteria,1KAMY@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Domain of unknown function (DUF1330)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1330
HKD3_k127_4038937_10	497964.CfE428DRAFT_2439	9.406e-106	347.0	COG0613@1|root,COG0613@2|Bacteria,46UTR@74201|Verrucomicrobia	74201|Verrucomicrobia	S	PHP-associated	-	-	-	-	-	-	-	-	-	-	-	-	PHP,PHP_C
HKD3_k127_4038937_7	401526.TcarDRAFT_0104	1.743e-129	437.0	COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,4H20M@909932|Negativicutes	909932|Negativicutes	V	lipid A export permease ATP-binding protein MsbA	msbA	-	-	ko:K11085	ko02010,map02010	-	-	-	ko00000,ko00001,ko01000,ko02000	3.A.1.106	-	-	ABC_membrane,ABC_tran
HKD3_k127_4038937_29	497964.CfE428DRAFT_5305	6.11e-59	217.0	COG0859@1|root,COG0859@2|Bacteria,46VBS@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Glycosyltransferase family 9 (heptosyltransferase)	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_9
HKD3_k127_4038937_6	497964.CfE428DRAFT_1581	3.188e-141	462.0	COG0438@1|root,COG0438@2|Bacteria,46TF4@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4
HKD3_k127_4038937_12	497964.CfE428DRAFT_5304	1.3e-99	336.0	COG0438@1|root,COG0438@2|Bacteria,46W2P@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Glycosyltransferase Family 4	-	-	-	ko:K02844	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT4	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
HKD3_k127_4038937_35	497964.CfE428DRAFT_5327	7.288e-30	122.0	COG1366@1|root,COG1366@2|Bacteria	2|Bacteria	T	antisigma factor binding	-	-	-	ko:K04749	-	-	-	-	ko00000,ko03021	-	-	-	STAS,STAS_2
HKD3_k127_4038937_17	497964.CfE428DRAFT_2435	7.371e-82	278.0	COG0546@1|root,COG0546@2|Bacteria,46SW1@74201|Verrucomicrobia	74201|Verrucomicrobia	S	haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD,HAD_2
HKD3_k127_4038937_46	525904.Tter_1427	2.848e-13	78.0	COG1716@1|root,COG1716@2|Bacteria,2NQ4X@2323|unclassified Bacteria	2|Bacteria	T	Inner membrane component of T3SS, cytoplasmic domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF3662,FHA,Yop-YscD_cpl
HKD3_k127_4038937_0	349741.Amuc_1036	3.244e-276	860.0	COG0481@1|root,COG0481@2|Bacteria,46SA7@74201|Verrucomicrobia,2IU2I@203494|Verrucomicrobiae	203494|Verrucomicrobiae	M	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner	lepA	-	-	ko:K03596	ko05134,map05134	-	-	-	ko00000,ko00001	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2,LepA_C
HKD3_k127_4038937_13	497964.CfE428DRAFT_2117	2.909e-96	326.0	COG0681@1|root,COG0681@2|Bacteria,46SR0@74201|Verrucomicrobia	74201|Verrucomicrobia	U	Belongs to the peptidase S26 family	lepB	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24,Peptidase_S26
HKD3_k127_4038937_16	497964.CfE428DRAFT_2670	1.121e-83	289.0	COG1562@1|root,COG1562@2|Bacteria,46TVP@74201|Verrucomicrobia	74201|Verrucomicrobia	I	Squalene/phytoene synthase	-	-	2.5.1.32,2.5.1.99	ko:K02291	ko00906,ko01062,ko01100,ko01110,map00906,map01062,map01100,map01110	M00097	R02065,R04218,R07270,R10177	RC00362,RC01101,RC02869	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	Amino_oxidase,SQS_PSY
HKD3_k127_4038937_48	1144312.PMI09_03588	1.522e-06	55.0	2EBP1@1|root,335P7@2|Bacteria,1NEQC@1224|Proteobacteria,2UF3H@28211|Alphaproteobacteria,4BG1E@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Glycine-zipper domain	-	-	-	-	-	-	-	-	-	-	-	-	Gly-zipper_Omp,Gly-zipper_YMGG
HKD3_k127_4038937_2	478741.JAFS01000002_gene189	5.859e-206	650.0	COG0043@1|root,COG0043@2|Bacteria,46TYE@74201|Verrucomicrobia,37G34@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	H	3-octaprenyl-4-hydroxybenzoate carboxy-lyase	ubiD	-	4.1.1.98	ko:K03182	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04985,R04986	RC00391	ko00000,ko00001,ko00002,ko01000	-	-	-	UbiD
HKD3_k127_4038937_45	1396141.BATP01000026_gene1042	3.457e-14	78.0	2F8IJ@1|root,340XC@2|Bacteria,46WTZ@74201|Verrucomicrobia,2IUYP@203494|Verrucomicrobiae	203494|Verrucomicrobiae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_4038937_47	1396141.BATP01000026_gene1042	2.711e-10	66.0	2F8IJ@1|root,340XC@2|Bacteria,46WTZ@74201|Verrucomicrobia,2IUYP@203494|Verrucomicrobiae	203494|Verrucomicrobiae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_4038937_8	240016.ABIZ01000001_gene2263	1.042e-115	381.0	COG2896@1|root,COG2896@2|Bacteria,46V5U@74201|Verrucomicrobia,2IU2K@203494|Verrucomicrobiae	203494|Verrucomicrobiae	H	Molybdenum Cofactor Synthesis C	-	-	-	-	-	-	-	-	-	-	-	-	Mob_synth_C,Radical_SAM
HKD3_k127_4038937_31	1403819.BATR01000103_gene3461	7.231e-45	168.0	COG0315@1|root,COG0315@2|Bacteria,46VUN@74201|Verrucomicrobia,2IUS5@203494|Verrucomicrobiae	203494|Verrucomicrobiae	H	MoaC family	-	-	-	-	-	-	-	-	-	-	-	-	MoaC
HKD3_k127_4038937_22	1403819.BATR01000103_gene3462	3.641e-70	241.0	COG0521@1|root,COG0521@2|Bacteria,46SVJ@74201|Verrucomicrobia,2IUE2@203494|Verrucomicrobiae	203494|Verrucomicrobiae	H	Probable molybdopterin binding domain	-	-	-	-	-	-	-	-	-	-	-	-	MoCF_biosynth
HKD3_k127_4038937_14	240016.ABIZ01000001_gene1479	2.035e-92	315.0	COG0739@1|root,COG0739@2|Bacteria,46V20@74201|Verrucomicrobia,2IU1Z@203494|Verrucomicrobiae	203494|Verrucomicrobiae	M	Peptidase family M23	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
HKD3_k127_4038937_38	497964.CfE428DRAFT_1899	2.465e-25	113.0	2DCGW@1|root,2ZE4S@2|Bacteria,46WFZ@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Intracellular proteinase inhibitor	-	-	-	-	-	-	-	-	-	-	-	-	BsuPI
HKD3_k127_4038937_18	478741.JAFS01000002_gene923	3.713e-80	277.0	COG1387@1|root,COG1387@2|Bacteria,46YX1@74201|Verrucomicrobia,37GCT@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	E	Histidinol phosphatase and related hydrolases of the PHP family	-	-	3.1.3.15	ko:K04486	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R03013	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	-
HKD3_k127_4038937_15	497964.CfE428DRAFT_3318	1.431e-87	298.0	COG1801@1|root,COG1801@2|Bacteria	2|Bacteria	L	Protein of unknown function DUF72	yecE	-	-	-	-	-	-	-	-	-	-	-	DUF72
HKD3_k127_4038937_28	497964.CfE428DRAFT_3832	1.017e-59	222.0	COG1729@1|root,COG4105@1|root,COG1729@2|Bacteria,COG4105@2|Bacteria,46SYU@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Tetratricopeptide TPR_2 repeat protein	-	-	-	ko:K05807	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	TPR_16,TPR_6,YfiO
HKD3_k127_4038937_32	497964.CfE428DRAFT_3831	1.594e-43	165.0	2EM72@1|root,33EW9@2|Bacteria,46TAB@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Lipopolysaccharide-assembly	-	-	-	-	-	-	-	-	-	-	-	-	LptE
HKD3_k127_4038937_34	46234.ANA_C12350	9.997e-32	135.0	COG0457@1|root,COG0457@2|Bacteria,1G0N0@1117|Cyanobacteria,1HQK0@1161|Nostocales	1117|Cyanobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_12,TPR_7
HKD3_k127_4038937_21	497964.CfE428DRAFT_2296	1.152e-74	257.0	COG0500@1|root,COG2226@2|Bacteria,46STX@74201|Verrucomicrobia	74201|Verrucomicrobia	H	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2)	menG	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Ubie_methyltran
HKD3_k127_4038937_19	497964.CfE428DRAFT_0731	2.599e-76	262.0	COG0811@1|root,COG0811@2|Bacteria,46SUA@74201|Verrucomicrobia	74201|Verrucomicrobia	U	PFAM MotA TolQ ExbB proton channel	-	-	-	ko:K03561	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	MotA_ExbB
HKD3_k127_4038937_39	497964.CfE428DRAFT_0730	2.264e-22	102.0	COG0848@1|root,COG0848@2|Bacteria,46T9R@74201|Verrucomicrobia	74201|Verrucomicrobia	U	Biopolymer transport protein ExbD/TolR	-	-	-	ko:K03559	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	ExbD
HKD3_k127_4038937_43	240016.ABIZ01000001_gene546	2.815e-16	89.0	298B0@1|root,2ZVGI@2|Bacteria,46WFY@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_4038937_4	481448.Minf_0245	9.063e-180	570.0	COG0516@1|root,COG0516@2|Bacteria,46W51@74201|Verrucomicrobia,37FWR@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	F	IMP dehydrogenase / GMP reductase domain	guaB	-	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,IMPDH
HKD3_k127_4038937_5	635013.TherJR_2071	6.972e-165	529.0	COG0304@1|root,COG0304@2|Bacteria,1TPA7@1239|Firmicutes,247VF@186801|Clostridia,2602N@186807|Peptococcaceae	186801|Clostridia	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	fabF	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
HKD3_k127_4038937_49	1089548.KI783301_gene1	2.507e-05	46.0	2DG4E@1|root,2ZUFG@2|Bacteria,1W47E@1239|Firmicutes,4I1MM@91061|Bacilli	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_4038937_30	497964.CfE428DRAFT_6117	8.698e-57	205.0	COG0558@1|root,COG0558@2|Bacteria,46VZY@74201|Verrucomicrobia	74201|Verrucomicrobia	I	CDP-alcohol phosphatidyltransferase	-	-	2.7.8.5	ko:K00995	ko00564,ko01100,map00564,map01100	-	R01801	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
HKD3_k127_4038937_37	481448.Minf_1881	9.426e-26	112.0	COG0314@1|root,COG0314@2|Bacteria,46T71@74201|Verrucomicrobia,37GVA@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	H	MoaE protein	moaE	-	2.8.1.12	ko:K03635	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09395	RC02507	ko00000,ko00001,ko01000	-	-	-	MoaE
HKD3_k127_4038937_3	235909.GK2344	1.39e-193	615.0	COG0362@1|root,COG0362@2|Bacteria,1TP4I@1239|Firmicutes,4H9NC@91061|Bacilli,1WEEJ@129337|Geobacillus	91061|Bacilli	G	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH	gnd	-	1.1.1.343,1.1.1.44	ko:K00033	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200	M00004,M00006	R01528,R10221	RC00001,RC00539	ko00000,ko00001,ko00002,ko01000	-	-	-	6PGD,NAD_binding_2
HKD3_k127_4038937_33	497964.CfE428DRAFT_3426	1.895e-36	145.0	COG0491@1|root,COG0491@2|Bacteria	2|Bacteria	GM	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_5
HKD3_k127_4038937_23	497964.CfE428DRAFT_1863	6.053e-70	246.0	COG0382@1|root,COG0382@2|Bacteria,46UH5@74201|Verrucomicrobia	74201|Verrucomicrobia	H	UbiA prenyltransferase family	ubiA	-	2.5.1.39	ko:K03179	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R05000,R05615	RC00209,RC02895	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
HKD3_k127_4038937_27	1185876.BN8_03503	4.38e-64	222.0	COG0698@1|root,COG0698@2|Bacteria,4NNSU@976|Bacteroidetes,47PQK@768503|Cytophagia	976|Bacteroidetes	G	Ribose 5-phosphate isomerase	rpiB	-	5.3.1.6	ko:K01808	ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01056,R09030	RC00376,RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	LacAB_rpiB
HKD3_k127_4038937_11	497964.CfE428DRAFT_3540	1.871e-103	345.0	COG0484@1|root,COG0484@2|Bacteria,46S6P@74201|Verrucomicrobia	74201|Verrucomicrobia	O	DnaJ molecular chaperone homology domain	cbpA	-	-	ko:K05516	-	-	-	-	ko00000,ko03036,ko03110	-	-	-	DnaJ,DnaJ_C
HKD3_k127_4038937_44	1408303.JNJJ01000037_gene54	7.102e-15	77.0	2DNS1@1|root,32YVX@2|Bacteria,1VEGC@1239|Firmicutes,4HPC6@91061|Bacilli,1ZJ6M@1386|Bacillus	91061|Bacilli	S	Protein of unknown function (DUF2905)	yrzS	-	-	-	-	-	-	-	-	-	-	-	DUF2905
HKD3_k127_4038937_24	497964.CfE428DRAFT_1671	2.842e-69	241.0	COG1573@1|root,COG1573@2|Bacteria,46V7R@74201|Verrucomicrobia	74201|Verrucomicrobia	L	PFAM Uracil-DNA glycosylase superfamily	-	-	3.2.2.27	ko:K03648	ko03410,ko05340,map03410,map05340	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
HKD3_k127_4038937_1	497964.CfE428DRAFT_2384	9.481e-242	760.0	COG1164@1|root,COG1164@2|Bacteria,46UYD@74201|Verrucomicrobia	74201|Verrucomicrobia	E	PFAM peptidase M3A and M3B thimet oligopeptidase F	-	-	-	ko:K08602	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3,Peptidase_M3_N
HKD3_k127_4038937_25	1396418.BATQ01000171_gene2961	1.56e-67	237.0	COG1680@1|root,COG1680@2|Bacteria,46WBQ@74201|Verrucomicrobia,2ITZX@203494|Verrucomicrobiae	203494|Verrucomicrobiae	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
HKD3_k127_4044621_3	349741.Amuc_2115	1.773e-38	145.0	COG0172@1|root,COG0172@2|Bacteria,46S70@74201|Verrucomicrobia,2ITV1@203494|Verrucomicrobiae	203494|Verrucomicrobiae	J	Seryl-tRNA synthetase N-terminal domain	-	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Seryl_tRNA_N,tRNA-synt_2b
HKD3_k127_4044621_4	497964.CfE428DRAFT_1755	7.645e-32	129.0	COG0718@1|root,COG0718@2|Bacteria,46TA9@74201|Verrucomicrobia	74201|Verrucomicrobia	L	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection	-	-	-	ko:K09747	-	-	-	-	ko00000	-	-	-	YbaB_DNA_bd
HKD3_k127_4044621_0	1403819.BATR01000104_gene3614	5.049e-141	465.0	COG2812@1|root,COG2812@2|Bacteria,46SGC@74201|Verrucomicrobia,2ITGI@203494|Verrucomicrobiae	203494|Verrucomicrobiae	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity	dnaX	-	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNA_pol3_gamma3
HKD3_k127_4044621_5	1234364.AMSF01000061_gene2077	5.051e-18	90.0	2EUEA@1|root,33MWN@2|Bacteria,1NYM7@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_4044621_1	204669.Acid345_3656	9.6e-140	454.0	COG3191@1|root,COG3191@2|Bacteria	2|Bacteria	EQ	aminopeptidase activity	dmpA	-	3.4.11.19	ko:K01266	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S58
HKD3_k127_4044621_2	457570.Nther_2188	1.317e-55	216.0	COG4805@1|root,COG4805@2|Bacteria	2|Bacteria	S	Bacterial protein of unknown function (DUF885)	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
HKD3_k127_4044621_6	1157638.KB892165_gene3730	4.19e-06	49.0	COG2211@1|root,COG2211@2|Bacteria,2I31J@201174|Actinobacteria	201174|Actinobacteria	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD3_k127_4053469_0	1340493.JNIF01000003_gene4071	7.039e-137	448.0	COG0520@1|root,COG0520@2|Bacteria,3Y4TH@57723|Acidobacteria	57723|Acidobacteria	E	Aminotransferase class-V	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
HKD3_k127_4053469_1	1205680.CAKO01000010_gene3839	1.607e-96	327.0	COG0329@1|root,COG0329@2|Bacteria,1MXM5@1224|Proteobacteria,2TUAG@28211|Alphaproteobacteria,2JRY4@204441|Rhodospirillales	204441|Rhodospirillales	EM	Belongs to the DapA family	-	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
HKD3_k127_4061665_2	497964.CfE428DRAFT_1447	2.934e-204	645.0	COG0265@1|root,COG0823@1|root,COG2234@1|root,COG0265@2|Bacteria,COG0823@2|Bacteria,COG2234@2|Bacteria,46T85@74201|Verrucomicrobia	74201|Verrucomicrobia	OU	PA domain	-	-	-	-	-	-	-	-	-	-	-	-	PA,PD40,PDZ_2,Peptidase_M28
HKD3_k127_4061665_6	251229.Chro_4406	1.621e-134	436.0	COG0167@1|root,COG0167@2|Bacteria,1G2B6@1117|Cyanobacteria,3VJ02@52604|Pleurocapsales	1117|Cyanobacteria	F	Catalyzes the conversion of dihydroorotate to orotate	-	-	1.3.98.1	ko:K00226	ko00240,ko01100,map00240,map01100	M00051	R01867	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
HKD3_k127_4061665_4	251229.Chro_4406	4.802e-148	475.0	COG0167@1|root,COG0167@2|Bacteria,1G2B6@1117|Cyanobacteria,3VJ02@52604|Pleurocapsales	1117|Cyanobacteria	F	Catalyzes the conversion of dihydroorotate to orotate	-	-	1.3.98.1	ko:K00226	ko00240,ko01100,map00240,map01100	M00051	R01867	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
HKD3_k127_4061665_0	98439.AJLL01000072_gene1223	0.0	1697.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1146@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1146@2|Bacteria,1G2E2@1117|Cyanobacteria	1117|Cyanobacteria	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	-	-	1.2.7.1	ko:K03737	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00173,M00307	R01196,R10866	RC00004,RC02742	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	EKR,Fer4_16,PFOR_II,POR,POR_N,TPP_enzyme_C
HKD3_k127_4061665_1	76114.ebA4954	1.324e-236	740.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2VHNN@28216|Betaproteobacteria,2KVWA@206389|Rhodocyclales	206389|Rhodocyclales	C	Aldehyde dehydrogenase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldedh
HKD3_k127_4061665_7	926562.Oweho_1533	3.762e-115	382.0	COG0276@1|root,COG0276@2|Bacteria,4NE83@976|Bacteroidetes,1HXUV@117743|Flavobacteriia,2PAT3@246874|Cryomorphaceae	976|Bacteroidetes	H	Catalyzes the ferrous insertion into protoporphyrin IX	hemH	-	4.99.1.1,4.99.1.9	ko:K01772	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R00310,R11329	RC01012	ko00000,ko00001,ko00002,ko01000	-	-	-	Ferrochelatase
HKD3_k127_4061665_8	452637.Oter_2694	2.032e-113	384.0	COG1232@1|root,COG1232@2|Bacteria,46UPY@74201|Verrucomicrobia,3K7GZ@414999|Opitutae	414999|Opitutae	H	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX	-	-	1.3.3.15,1.3.3.4	ko:K00231	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03222,R04178	RC00885	ko00000,ko00001,ko00002,ko01000	-	-	-	Amino_oxidase
HKD3_k127_4061665_3	583355.Caka_2769	1.017e-153	504.0	COG0635@1|root,COG0635@2|Bacteria,46TQX@74201|Verrucomicrobia,3K7DD@414999|Opitutae	414999|Opitutae	H	Belongs to the anaerobic coproporphyrinogen-III oxidase family	-	-	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
HKD3_k127_4061665_9	452637.Oter_2695	1.315e-111	371.0	COG0407@1|root,COG0407@2|Bacteria,46UU6@74201|Verrucomicrobia,3K7H3@414999|Opitutae	414999|Opitutae	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	hemE	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
HKD3_k127_4061665_5	290397.Adeh_1565	1.401e-147	490.0	COG0370@1|root,COG0370@2|Bacteria,1MUZC@1224|Proteobacteria,42MCY@68525|delta/epsilon subdivisions,2WIWJ@28221|Deltaproteobacteria,2YYYV@29|Myxococcales	28221|Deltaproteobacteria	P	transporter of a GTP-driven Fe(2 ) uptake system	-	-	-	ko:K04759	-	-	-	-	ko00000,ko02000	9.A.8.1	-	-	FeoB_C,FeoB_N,Gate
HKD3_k127_4061665_10	438753.AZC_1197	4.932e-68	238.0	COG0259@1|root,COG0259@2|Bacteria,1NZUU@1224|Proteobacteria,2TT1U@28211|Alphaproteobacteria,3EXXX@335928|Xanthobacteraceae	28211|Alphaproteobacteria	H	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP)	pdxH	GO:0003674,GO:0003824,GO:0004733,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0016491,GO:0016638,GO:0016641,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0042364,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046184,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	1.4.3.5	ko:K00275	ko00750,ko01100,ko01120,map00750,map01100,map01120	M00124	R00277,R00278,R01710,R01711	RC00048,RC00116	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_phzG_C,Putative_PNPOx
HKD3_k127_4061665_11	485915.Dret_1750	1.73e-16	81.0	COG0021@1|root,COG0021@2|Bacteria	2|Bacteria	G	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_N,XFP,XFP_N
HKD3_k127_41271_2	497964.CfE428DRAFT_4166	6.177e-129	415.0	COG0215@1|root,COG0215@2|Bacteria,46SES@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	-	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e
HKD3_k127_41271_15	497964.CfE428DRAFT_4165	6.467e-58	205.0	COG0245@1|root,COG0245@2|Bacteria,46T29@74201|Verrucomicrobia	74201|Verrucomicrobia	I	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP)	ispF	-	4.6.1.12	ko:K01770	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05637	RC00002,RC01440	ko00000,ko00001,ko00002,ko01000	-	-	-	YgbB
HKD3_k127_41271_12	497964.CfE428DRAFT_4164	8.169e-94	313.0	COG0483@1|root,COG0483@2|Bacteria,46T0Z@74201|Verrucomicrobia	74201|Verrucomicrobia	G	Inositol monophosphatase family	suhB	-	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
HKD3_k127_41271_17	1460635.JCM19038_1199	2.58e-49	183.0	COG0452@1|root,COG0452@2|Bacteria,1TPP3@1239|Firmicutes,4HAK8@91061|Bacilli	91061|Bacilli	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	coaBC	-	4.1.1.36,6.3.2.5	ko:K01598,ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	DFP,Flavoprotein
HKD3_k127_41271_13	497964.CfE428DRAFT_4163	3.771e-73	252.0	COG0452@1|root,COG0452@2|Bacteria,46SPU@74201|Verrucomicrobia	74201|Verrucomicrobia	H	Flavoprotein	-	-	4.1.1.36	ko:K01598	ko00770,ko01100,map00770,map01100	M00120	R03269	RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	Flavoprotein
HKD3_k127_41271_14	1156937.MFUM_700135	2.182e-71	249.0	COG0194@1|root,COG0194@2|Bacteria,46SQG@74201|Verrucomicrobia,37GTD@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	F	Guanylate kinase	gmk	-	2.7.4.8	ko:K00942	ko00230,ko01100,map00230,map01100	M00050	R00332,R02090	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_kin
HKD3_k127_41271_5	497964.CfE428DRAFT_4161	1.989e-117	384.0	COG1561@1|root,COG1561@2|Bacteria,46TP9@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Domain of unknown function (DUF1732)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1732,YicC_N
HKD3_k127_41271_9	404589.Anae109_2127	2.693e-100	341.0	COG1055@1|root,COG1055@2|Bacteria,1NEVR@1224|Proteobacteria,42NU5@68525|delta/epsilon subdivisions,2WJV4@28221|Deltaproteobacteria,2YX9Q@29|Myxococcales	28221|Deltaproteobacteria	P	Arsenical pump membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS
HKD3_k127_41271_11	497964.CfE428DRAFT_4767	9.63e-96	330.0	COG1194@1|root,COG1194@2|Bacteria,46SR4@74201|Verrucomicrobia	74201|Verrucomicrobia	L	endonuclease III	mutY	-	-	ko:K03575	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD,NUDIX_4
HKD3_k127_41271_7	497964.CfE428DRAFT_4766	6.991e-114	376.0	COG1039@1|root,COG1039@2|Bacteria,46UTB@74201|Verrucomicrobia	74201|Verrucomicrobia	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	-	-	3.1.26.4	ko:K03471	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_HII
HKD3_k127_41271_19	497964.CfE428DRAFT_4765	3.095e-39	150.0	COG0776@1|root,COG0776@2|Bacteria,46T4V@74201|Verrucomicrobia	74201|Verrucomicrobia	L	Belongs to the bacterial histone-like protein family	-	-	-	ko:K03530,ko:K04764	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
HKD3_k127_41271_10	886293.Sinac_6389	3.216e-100	357.0	COG0745@1|root,COG2202@1|root,COG5002@1|root,COG0745@2|Bacteria,COG2202@2|Bacteria,COG5002@2|Bacteria	2|Bacteria	T	protein histidine kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF4118,GAF_2,HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_9,Response_reg
HKD3_k127_41271_0	497964.CfE428DRAFT_2520	3.755e-216	682.0	COG1215@1|root,COG1215@2|Bacteria,46SF7@74201|Verrucomicrobia	74201|Verrucomicrobia	M	glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3,Glyco_trans_2_3
HKD3_k127_41271_16	497964.CfE428DRAFT_2522	2.934e-52	193.0	COG1376@1|root,COG1376@2|Bacteria,46VQZ@74201|Verrucomicrobia	74201|Verrucomicrobia	S	L,D-transpeptidase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	YkuD
HKD3_k127_41271_23	91464.S7335_1834	2.722e-06	53.0	COG0268@1|root,COG0268@2|Bacteria,1G7PV@1117|Cyanobacteria,1H0RF@1129|Synechococcus	1117|Cyanobacteria	J	Binds directly to 16S ribosomal RNA	rpsT	-	-	ko:K02968	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S20p
HKD3_k127_41271_18	497964.CfE428DRAFT_2131	1.758e-41	161.0	29NX7@1|root,309VB@2|Bacteria,46WPG@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_41271_8	671143.DAMO_1598	3.084e-105	350.0	COG1071@1|root,COG1071@2|Bacteria,2NQC2@2323|unclassified Bacteria	2|Bacteria	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	pdhA	-	1.2.4.1,1.2.4.4	ko:K00161,ko:K11381	ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00036,M00307	R00014,R00209,R01699,R03270,R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00004,RC00027,RC00627,RC02742,RC02743,RC02744,RC02882,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
HKD3_k127_41271_4	886293.Sinac_6549	1.366e-121	398.0	COG0022@1|root,COG0022@2|Bacteria,2IYRX@203682|Planctomycetes	203682|Planctomycetes	C	Transketolase, pyrimidine binding domain	-	-	1.2.4.1	ko:K00162	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh,Transket_pyr,Transketolase_C
HKD3_k127_41271_6	497964.CfE428DRAFT_0130	7.77e-117	391.0	COG0508@1|root,COG0508@2|Bacteria,46SHZ@74201|Verrucomicrobia	74201|Verrucomicrobia	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	-	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
HKD3_k127_41271_22	309803.CTN_0697	2.168e-11	71.0	COG3339@1|root,COG3339@2|Bacteria,2GEFC@200918|Thermotogae	200918|Thermotogae	S	Protein of unknown function (DUF1232)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1232
HKD3_k127_41271_3	395961.Cyan7425_2963	2.164e-123	404.0	COG0500@1|root,COG2226@2|Bacteria,1FZVZ@1117|Cyanobacteria	1117|Cyanobacteria	Q	Dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	Dimerisation2,Methyltransf_2
HKD3_k127_41271_1	497964.CfE428DRAFT_5373	9.754e-146	472.0	COG0232@1|root,COG0232@2|Bacteria,46UHP@74201|Verrucomicrobia	74201|Verrucomicrobia	F	SMART metal-dependent phosphohydrolase HD region	-	-	3.1.5.1	ko:K01129	ko00230,map00230	-	R01856	RC00017	ko00000,ko00001,ko01000	-	-	-	HD,HD_assoc
HKD3_k127_41271_21	497964.CfE428DRAFT_5372	3.25e-37	150.0	COG0466@1|root,COG0466@2|Bacteria,46WE2@74201|Verrucomicrobia	74201|Verrucomicrobia	O	PFAM peptidase S16 lon domain protein	-	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	LON_substr_bdg
HKD3_k127_41271_20	497964.CfE428DRAFT_4615	6.257e-39	153.0	COG0710@1|root,COG0710@2|Bacteria,46VMG@74201|Verrucomicrobia	74201|Verrucomicrobia	E	Type I 3-dehydroquinase	aroD	-	4.2.1.10	ko:K03785	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03084	RC00848	ko00000,ko00001,ko00002,ko01000	-	-	-	DHquinase_I
HKD3_k127_4132021_0	448385.sce7110	1.025e-24	103.0	COG0454@1|root,COG0456@2|Bacteria,1PWDA@1224|Proteobacteria,43586@68525|delta/epsilon subdivisions,2WZJ8@28221|Deltaproteobacteria,2Z296@29|Myxococcales	28221|Deltaproteobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HKD3_k127_4132021_6	573413.Spirs_0104	1.192e-06	57.0	COG3797@1|root,COG3797@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF1697)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1697
HKD3_k127_4132021_4	1545915.JROG01000004_gene2589	2.897e-11	70.0	COG3631@1|root,COG3631@2|Bacteria,1NUJT@1224|Proteobacteria,2URVR@28211|Alphaproteobacteria,2KA61@204457|Sphingomonadales	204457|Sphingomonadales	S	Domain of unknown function (DUF4440)	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_4132021_3	497964.CfE428DRAFT_5477	2.326e-19	95.0	COG3386@1|root,COG3386@2|Bacteria	2|Bacteria	G	gluconolactonase activity	-	-	-	-	-	-	-	-	-	-	-	-	NHL,SGL
HKD3_k127_4132021_1	1280946.HY29_02435	1.76e-22	103.0	COG0406@1|root,COG0406@2|Bacteria,1N92W@1224|Proteobacteria,2UGMI@28211|Alphaproteobacteria,43Y8Q@69657|Hyphomonadaceae	28211|Alphaproteobacteria	G	Phosphoglycerate mutase family	-	-	-	-	-	-	-	-	-	-	-	-	His_Phos_1
HKD3_k127_4132021_5	497964.CfE428DRAFT_0891	2.545e-10	68.0	2DBSP@1|root,2ZAT9@2|Bacteria,46TYZ@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_4132021_2	497964.CfE428DRAFT_1170	1.282e-19	90.0	COG3011@1|root,COG3011@2|Bacteria,46U84@74201|Verrucomicrobia	2|Bacteria	S	Lipase maturation factor	LMF	-	-	-	-	-	-	-	-	-	-	-	LMF1
HKD3_k127_4140572_3	1205680.CAKO01000010_gene3839	1.357e-21	94.0	COG0329@1|root,COG0329@2|Bacteria,1MXM5@1224|Proteobacteria,2TUAG@28211|Alphaproteobacteria,2JRY4@204441|Rhodospirillales	204441|Rhodospirillales	EM	Belongs to the DapA family	-	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
HKD3_k127_4140572_0	497964.CfE428DRAFT_0899	1.515e-143	463.0	COG0820@1|root,COG0820@2|Bacteria,46SBD@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs	rlmN	-	2.1.1.192	ko:K06941	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Radical_SAM
HKD3_k127_4140572_5	631362.Thi970DRAFT_03342	0.0002033	46.0	COG1724@1|root,COG1724@2|Bacteria,1NHPS@1224|Proteobacteria,1SGDT@1236|Gammaproteobacteria,1WZRG@135613|Chromatiales	135613|Chromatiales	N	HicA toxin of bacterial toxin-antitoxin,	-	-	-	ko:K07339	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	HicA_toxin
HKD3_k127_4140572_1	395492.Rleg2_3602	2.545e-32	137.0	2D2IW@1|root,32TCX@2|Bacteria,1N4MH@1224|Proteobacteria,2U5DM@28211|Alphaproteobacteria,4BKZQ@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1353)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1353
HKD3_k127_4140572_4	357808.RoseRS_0379	7.823e-20	91.0	COG5499@1|root,COG5499@2|Bacteria,2GB4I@200795|Chloroflexi,377WX@32061|Chloroflexia	32061|Chloroflexia	K	transcription regulator containing HTH domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_4140572_2	204669.Acid345_3332	9.304e-23	100.0	COG2318@1|root,COG2318@2|Bacteria,3Y4TP@57723|Acidobacteria,2JJPR@204432|Acidobacteriia	204432|Acidobacteriia	S	DinB superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
HKD3_k127_4166778_12	1454004.AW11_02570	1.879e-27	113.0	COG4274@1|root,COG4274@2|Bacteria,1MZVV@1224|Proteobacteria,2VUPM@28216|Betaproteobacteria	28216|Betaproteobacteria	S	PFAM GYD family protein	-	-	-	-	-	-	-	-	-	-	-	-	GYD
HKD3_k127_4166778_5	497964.CfE428DRAFT_6076	3.664e-100	331.0	COG5530@1|root,COG5530@2|Bacteria	2|Bacteria	S	Predicted integral membrane protein (DUF2270)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2270
HKD3_k127_4166778_18	240016.ABIZ01000001_gene4134	2.571e-12	73.0	COG1762@1|root,COG1762@2|Bacteria	2|Bacteria	G	phosphoenolpyruvate-dependent sugar phosphotransferase system	ptsN	GO:0001932,GO:0001934,GO:0003674,GO:0003824,GO:0004857,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006810,GO:0008047,GO:0008150,GO:0008643,GO:0009401,GO:0009893,GO:0010033,GO:0010243,GO:0010562,GO:0010604,GO:0015144,GO:0016020,GO:0016740,GO:0016772,GO:0016773,GO:0019207,GO:0019209,GO:0019220,GO:0019222,GO:0019887,GO:0022804,GO:0022857,GO:0022898,GO:0030234,GO:0030295,GO:0031323,GO:0031325,GO:0031399,GO:0031401,GO:0032147,GO:0032268,GO:0032270,GO:0032409,GO:0032412,GO:0032879,GO:0033674,GO:0034219,GO:0034762,GO:0034765,GO:0042221,GO:0042325,GO:0042327,GO:0043085,GO:0043086,GO:0043269,GO:0043549,GO:0044092,GO:0044093,GO:0044424,GO:0044444,GO:0044464,GO:0045859,GO:0045860,GO:0045937,GO:0048518,GO:0048522,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051049,GO:0051171,GO:0051173,GO:0051174,GO:0051179,GO:0051234,GO:0051246,GO:0051247,GO:0051338,GO:0051347,GO:0055085,GO:0060255,GO:0065007,GO:0065009,GO:0071702,GO:0071944,GO:0080090,GO:0090563,GO:0098772,GO:1901698	2.7.1.202	ko:K02768,ko:K02769,ko:K02770,ko:K02806	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	M00273	R03232	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.2.1	-	-	PTS_EIIA_2
HKD3_k127_4166778_4	497964.CfE428DRAFT_6105	2.265e-102	340.0	COG1235@1|root,COG1235@2|Bacteria,46SKU@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
HKD3_k127_4166778_17	1005048.CFU_3651	1.643e-13	76.0	COG1555@1|root,COG1555@2|Bacteria,1PWEB@1224|Proteobacteria,2WBYZ@28216|Betaproteobacteria,4784S@75682|Oxalobacteraceae	28216|Betaproteobacteria	L	photosystem II stabilization	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_4166778_7	497964.CfE428DRAFT_6588	1.341e-89	301.0	COG1028@1|root,COG1028@2|Bacteria,46SNA@74201|Verrucomicrobia	74201|Verrucomicrobia	IQ	short-chain dehydrogenase reductase SDR	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short,adh_short_C2
HKD3_k127_4166778_14	1267533.KB906733_gene2848	3.095e-19	93.0	2E32R@1|root,32Y2Y@2|Bacteria,3Y5RV@57723|Acidobacteria,2JNI4@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_4166778_1	497964.CfE428DRAFT_6589	3.518e-135	440.0	COG1703@1|root,COG2185@1|root,COG1703@2|Bacteria,COG2185@2|Bacteria,46TIM@74201|Verrucomicrobia	74201|Verrucomicrobia	E	TIGRFAM LAO AO transport system ATPase	-	-	-	ko:K07588	-	-	-	-	ko00000,ko01000	-	-	-	ArgK,B12-binding
HKD3_k127_4166778_2	1120972.AUMH01000015_gene1333	3.662e-122	414.0	COG1703@1|root,COG1884@1|root,COG2185@1|root,COG1703@2|Bacteria,COG1884@2|Bacteria,COG2185@2|Bacteria,1TQAD@1239|Firmicutes,4HCMS@91061|Bacilli,27812@186823|Alicyclobacillaceae	91061|Bacilli	EI	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly	icmF	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0006139,GO:0006163,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009117,GO:0009150,GO:0009259,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016866,GO:0017076,GO:0017111,GO:0019001,GO:0019637,GO:0019693,GO:0019842,GO:0031419,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0034784,GO:0035383,GO:0035639,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043603,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0046906,GO:0046983,GO:0047727,GO:0048037,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:0097159,GO:0097367,GO:1901135,GO:1901265,GO:1901360,GO:1901363,GO:1901564	5.4.99.13	ko:K11942	-	-	-	-	ko00000,ko01000	-	-	-	ArgK,B12-binding,MM_CoA_mutase
HKD3_k127_4166778_15	497964.CfE428DRAFT_4320	3.375e-16	84.0	291K5@1|root,2ZP6G@2|Bacteria,46WPQ@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_4166778_6	697282.Mettu_4021	2.677e-94	316.0	COG1801@1|root,COG1801@2|Bacteria,1MU7F@1224|Proteobacteria,1RSAG@1236|Gammaproteobacteria,1XGED@135618|Methylococcales	135618|Methylococcales	S	Protein of unknown function DUF72	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
HKD3_k127_4166778_9	525897.Dbac_3076	1.191e-59	216.0	COG1573@1|root,COG1573@2|Bacteria,1RBA6@1224|Proteobacteria,42S3B@68525|delta/epsilon subdivisions,2WNST@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	Uracil DNA glycosylase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	UDG
HKD3_k127_4166778_3	497964.CfE428DRAFT_2620	2.002e-116	379.0	COG0330@1|root,COG0330@2|Bacteria,46VDU@74201|Verrucomicrobia	74201|Verrucomicrobia	O	prohibitin homologues	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
HKD3_k127_4166778_0	497964.CfE428DRAFT_4707	3.85e-184	580.0	COG1060@1|root,COG1060@2|Bacteria	2|Bacteria	H	7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase activity	mqnC	GO:0003674,GO:0003824,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016740,GO:0016765,GO:0044237,GO:0044249,GO:0044689,GO:0051186,GO:0051188	1.21.98.1,2.5.1.77	ko:K11779,ko:K11780,ko:K11781,ko:K11784	ko00130,ko00680,ko01110,ko01120,map00130,map00680,map01110,map01120	M00378	R08588,R09396	RC01381,RC02329,RC03002,RC03007	ko00000,ko00001,ko00002,ko01000	-	-	-	Radical_SAM
HKD3_k127_4166778_10	1116232.AHBF01000072_gene9132	5.513e-59	217.0	COG0665@1|root,COG0665@2|Bacteria,2GN2M@201174|Actinobacteria	201174|Actinobacteria	E	Glycine D-amino acid oxidases (deaminating)	-	-	1.4.3.3	ko:K00273	ko00260,ko00311,ko00330,ko00472,ko01100,ko01130,ko04146,map00260,map00311,map00330,map00472,map01100,map01130,map04146	-	R00366,R02457,R02894,R02923,R04221,R07400	RC00006,RC00018,RC00135	ko00000,ko00001,ko01000	-	-	-	DAO
HKD3_k127_4166778_11	1173022.Cri9333_4684	2.638e-50	186.0	COG2032@1|root,COG2032@2|Bacteria,1G9Z6@1117|Cyanobacteria,1HD5U@1150|Oscillatoriales	1117|Cyanobacteria	P	Copper/zinc superoxide dismutase (SODC)	-	-	1.15.1.1	ko:K04565	ko04146,ko04213,ko05014,ko05016,ko05020,map04146,map04213,map05014,map05016,map05020	-	-	-	ko00000,ko00001,ko01000	-	-	-	Sod_Cu
HKD3_k127_4166778_13	395964.KE386496_gene104	2.906e-20	93.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,2TRZD@28211|Alphaproteobacteria,3NC0G@45404|Beijerinckiaceae	28211|Alphaproteobacteria	P	Cation transporter/ATPase, N-terminus	-	-	3.6.3.6	ko:K01535	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.3.3	-	-	Cation_ATPase_N,E1-E2_ATPase,Hydrolase
HKD3_k127_417021_0	1187851.A33M_2254	1.781e-162	521.0	COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,2TQTB@28211|Alphaproteobacteria,3FCRE@34008|Rhodovulum	28211|Alphaproteobacteria	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	ntrY	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	2.7.13.3	ko:K13598	ko02020,map02020	M00498	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4
HKD3_k127_417021_1	596154.Alide2_2607	6.007e-06	51.0	COG2197@1|root,COG2197@2|Bacteria,1RAAY@1224|Proteobacteria,2VQ17@28216|Betaproteobacteria,4AAHC@80864|Comamonadaceae	28216|Betaproteobacteria	K	PFAM regulatory protein LuxR	-	-	-	-	-	-	-	-	-	-	-	-	GerE,PAS_9
HKD3_k127_4190518_2	595536.ADVE02000001_gene796	1.213e-29	123.0	COG0547@1|root,COG0547@2|Bacteria,1MUPV@1224|Proteobacteria,2TR8S@28211|Alphaproteobacteria,36XIB@31993|Methylocystaceae	28211|Alphaproteobacteria	E	Glycosyl transferase family, helical bundle domain	trpD	GO:0000162,GO:0003674,GO:0003824,GO:0004048,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.4.2.18,4.1.3.27	ko:K00766,ko:K13497	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R00985,R00986,R01073	RC00010,RC00440,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3
HKD3_k127_4190518_1	1460635.JCM19038_361	6.546e-55	212.0	COG0134@1|root,COG0135@1|root,COG0134@2|Bacteria,COG0135@2|Bacteria,1TR94@1239|Firmicutes,4HDZQ@91061|Bacilli	91061|Bacilli	E	Belongs to the TrpC family	trpC	GO:0003674,GO:0003824,GO:0004425,GO:0016829,GO:0016830,GO:0016831	4.1.1.48,5.3.1.24	ko:K01609,ko:K13498	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03508,R03509	RC00944,RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPS
HKD3_k127_4190518_0	1267535.KB906767_gene285	3.022e-62	216.0	COG0133@1|root,COG0133@2|Bacteria,3Y45B@57723|Acidobacteria,2JIVM@204432|Acidobacteriia	204432|Acidobacteriia	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB	-	4.2.1.20	ko:K01696	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HKD3_k127_4239511_1	272134.KB731324_gene5877	1.11e-138	451.0	COG0508@1|root,COG0508@2|Bacteria,1G0GX@1117|Cyanobacteria,1H8CP@1150|Oscillatoriales	2|Bacteria	C	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex	aceF	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
HKD3_k127_4239511_11	1131812.JQMS01000001_gene1964	3.44e-20	93.0	COG0236@1|root,COG0236@2|Bacteria,4NWTZ@976|Bacteroidetes,1IBDJ@117743|Flavobacteriia	976|Bacteroidetes	IQ	Phosphopantetheine attachment site	-	-	-	-	-	-	-	-	-	-	-	-	PP-binding
HKD3_k127_4239511_6	595460.RRSWK_00985	6.851e-78	271.0	COG1796@1|root,COG1796@2|Bacteria	2|Bacteria	L	DNA-directed DNA polymerase activity	dpbF	-	3.1.11.5	ko:K02347,ko:K03581,ko:K04477	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HHH_5,HHH_8
HKD3_k127_4239511_0	247490.KSU1_D0548	1.237e-160	514.0	COG0577@1|root,COG0577@2|Bacteria,2IWXH@203682|Planctomycetes	203682|Planctomycetes	V	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HKD3_k127_4239511_2	247490.KSU1_D0549	3.565e-93	316.0	COG1136@1|root,COG1136@2|Bacteria,2IYS3@203682|Planctomycetes	203682|Planctomycetes	V	PFAM ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD3_k127_4239511_4	247490.KSU1_D0550	3.616e-88	301.0	COG0845@1|root,COG0845@2|Bacteria,2IYUX@203682|Planctomycetes	203682|Planctomycetes	M	PFAM secretion protein HlyD	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
HKD3_k127_4239511_3	1396141.BATP01000056_gene3280	1.052e-91	312.0	COG1376@1|root,COG1376@2|Bacteria,46TD0@74201|Verrucomicrobia,2IU9W@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	L,D-transpeptidase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	YkuD
HKD3_k127_4239511_9	237368.SCABRO_02165	7.237e-32	139.0	COG0589@1|root,COG0589@2|Bacteria,2J12B@203682|Planctomycetes	203682|Planctomycetes	T	COG0589 Universal stress protein UspA and related	-	-	-	ko:K14055	-	-	-	-	ko00000	-	-	-	Usp
HKD3_k127_4239511_5	497964.CfE428DRAFT_3184	8.081e-84	286.0	COG1127@1|root,COG1127@2|Bacteria,46SRC@74201|Verrucomicrobia	74201|Verrucomicrobia	Q	PFAM ABC transporter related	-	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
HKD3_k127_4239511_8	518766.Rmar_1007	2.733e-36	150.0	COG0589@1|root,COG0589@2|Bacteria,4NFZ5@976|Bacteroidetes,1FJR9@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	T	Belongs to the universal stress protein A family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD3_k127_4239511_7	118163.Ple7327_0398	1.843e-74	256.0	COG1926@1|root,COG1926@2|Bacteria,1G2IS@1117|Cyanobacteria,3VJI1@52604|Pleurocapsales	1117|Cyanobacteria	S	PFAM Phosphoribosyl transferase domain	-	-	-	ko:K07100	-	-	-	-	ko00000	-	-	-	Pribosyltran
HKD3_k127_4239511_10	1479237.JMLY01000001_gene2639	1.732e-29	123.0	COG0517@1|root,COG0517@2|Bacteria,1QTVM@1224|Proteobacteria,1SFWU@1236|Gammaproteobacteria,46BCN@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
HKD3_k127_4240993_2	1286093.C266_05909	8.711e-32	126.0	2CNRS@1|root,32SHM@2|Bacteria,1NY57@1224|Proteobacteria,2W3Y5@28216|Betaproteobacteria,1KEN1@119060|Burkholderiaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_4240993_1	1123073.KB899243_gene664	1.69e-129	429.0	COG0534@1|root,COG0534@2|Bacteria,1MVRV@1224|Proteobacteria,1RRDQ@1236|Gammaproteobacteria,1X4AT@135614|Xanthomonadales	135614|Xanthomonadales	V	MatE	-	-	-	-	-	-	-	-	-	-	-	-	MatE
HKD3_k127_4240993_0	204669.Acid345_3443	5.442e-158	505.0	COG1574@1|root,COG1574@2|Bacteria,3Y2UF@57723|Acidobacteria,2JIRH@204432|Acidobacteriia	204432|Acidobacteriia	S	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
HKD3_k127_4247159_0	479434.Sthe_2852	1.097e-18	98.0	COG0628@1|root,COG0628@2|Bacteria,2G712@200795|Chloroflexi	200795|Chloroflexi	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
HKD3_k127_4247159_4	1121272.KB903255_gene5680	0.0005491	53.0	COG1404@1|root,COG1404@2|Bacteria,2I61R@201174|Actinobacteria,4DBU1@85008|Micromonosporales	201174|Actinobacteria	GO	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Peptidase_S8
HKD3_k127_4280205_4	1210884.HG799475_gene15269	2.519e-257	803.0	COG0033@1|root,COG0033@2|Bacteria,2IYG0@203682|Planctomycetes	203682|Planctomycetes	G	Phosphoglucomutase/phosphomannomutase, C-terminal domain	-	-	5.4.2.2	ko:K01835	ko00010,ko00030,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00549	R00959,R01057,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
HKD3_k127_4280205_1	420324.KI912022_gene340	0.0	1330.0	COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,2TRER@28211|Alphaproteobacteria,1JT1D@119045|Methylobacteriaceae	28211|Alphaproteobacteria	G	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties	-	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	Phosphorylase
HKD3_k127_4280205_0	243159.AFE_2053	0.0	1407.0	COG3957@1|root,COG3957@2|Bacteria,1MVSE@1224|Proteobacteria,1RPSW@1236|Gammaproteobacteria,2NCTC@225057|Acidithiobacillales	225057|Acidithiobacillales	G	XFP C-terminal domain	-	-	4.1.2.22,4.1.2.9	ko:K01621	ko00030,ko00710,ko01100,ko01120,map00030,map00710,map01100,map01120	-	R00761,R01621	RC00032,RC00226	ko00000,ko00001,ko01000	-	-	-	XFP,XFP_C,XFP_N
HKD3_k127_4280205_10	344747.PM8797T_23024	2.232e-79	269.0	COG0406@1|root,COG0406@2|Bacteria,2IZ7M@203682|Planctomycetes	203682|Planctomycetes	G	Phosphoglycerate mutase family	-	-	-	-	-	-	-	-	-	-	-	-	His_Phos_1
HKD3_k127_4280205_5	1207063.P24_07994	3.933e-153	491.0	COG0842@1|root,COG0842@2|Bacteria,1MUIA@1224|Proteobacteria,2TU4P@28211|Alphaproteobacteria,2JPXU@204441|Rhodospirillales	204441|Rhodospirillales	V	COG0842 ABC-type multidrug transport system, permease component	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
HKD3_k127_4280205_2	1054213.HMPREF9946_02780	0.0	1214.0	COG0842@1|root,COG1129@1|root,COG0842@2|Bacteria,COG1129@2|Bacteria,1QTT9@1224|Proteobacteria,2TW58@28211|Alphaproteobacteria,2JPP0@204441|Rhodospirillales	204441|Rhodospirillales	V	transporter, ATP-binding protein	-	-	-	ko:K13926	-	-	-	-	ko00000	-	-	-	ABC2_membrane_3,ABC_tran
HKD3_k127_4280205_6	1392838.AWNM01000087_gene3679	2.643e-114	381.0	COG0845@1|root,COG0845@2|Bacteria,1MUG6@1224|Proteobacteria,2VH7G@28216|Betaproteobacteria,3T1GM@506|Alcaligenaceae	28216|Betaproteobacteria	M	Barrel-sandwich domain of CusB or HlyD membrane-fusion	-	-	-	ko:K01993	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
HKD3_k127_4280205_11	497964.CfE428DRAFT_4351	2.71e-72	254.0	COG0583@1|root,COG0583@2|Bacteria,46TTX@74201|Verrucomicrobia	74201|Verrucomicrobia	K	LysR substrate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HKD3_k127_4280205_7	351160.RCIX2633	4.232e-101	340.0	COG0604@1|root,arCOG01458@2157|Archaea,2XURG@28890|Euryarchaeota,2N9N6@224756|Methanomicrobia	224756|Methanomicrobia	C	Zinc-binding dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N_2
HKD3_k127_4280205_9	1379270.AUXF01000007_gene997	1.074e-89	307.0	COG2819@1|root,COG2819@2|Bacteria	2|Bacteria	S	hydrolase activity, acting on ester bonds	-	-	-	-	-	-	-	-	-	-	-	-	Esterase
HKD3_k127_4280205_8	1396141.BATP01000039_gene1324	1.046e-89	304.0	COG1611@1|root,COG1611@2|Bacteria,46SEG@74201|Verrucomicrobia,2ITGC@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Possible lysine decarboxylase	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
HKD3_k127_4280205_3	357808.RoseRS_0827	2.02e-289	900.0	COG1523@1|root,COG1523@2|Bacteria,2G86B@200795|Chloroflexi,3763Y@32061|Chloroflexia	32061|Chloroflexia	G	Belongs to the glycosyl hydrolase 13 family	-	-	3.2.1.68	ko:K01214	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
HKD3_k127_432654_0	710685.MycrhN_2535	4.06e-309	979.0	COG2274@1|root,COG2274@2|Bacteria,2GNB5@201174|Actinobacteria,238WK@1762|Mycobacteriaceae	201174|Actinobacteria	V	ABC transporter transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran,Peptidase_C39
HKD3_k127_432654_11	251229.Chro_3250	2.598e-20	104.0	COG1566@1|root,COG1566@2|Bacteria,1GQC6@1117|Cyanobacteria	1117|Cyanobacteria	V	Alternative locus ID	-	-	-	ko:K02022	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD,HlyD_3
HKD3_k127_432654_6	215803.DB30_4454	1.329e-66	239.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2YYYX@29|Myxococcales	28221|Deltaproteobacteria	T	Magnesium chelatase, subunit ChlI	nla6	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD3_k127_432654_3	667632.KB890182_gene876	1.79e-104	357.0	COG1520@1|root,COG1520@2|Bacteria,1NDU1@1224|Proteobacteria,2WBCG@28216|Betaproteobacteria,1K4V0@119060|Burkholderiaceae	1224|Proteobacteria	S	Pyrrolo-quinoline quinone	-	-	-	-	-	-	-	-	-	-	-	-	PQQ,PQQ_3
HKD3_k127_432654_10	311403.Arad_3660	6.522e-26	115.0	COG0558@1|root,COG0558@2|Bacteria,1RHFC@1224|Proteobacteria,2UACA@28211|Alphaproteobacteria,4B80S@82115|Rhizobiaceae	28211|Alphaproteobacteria	I	cdp-diacylglycerol--glycerol-3-phosphate	pgsAb	-	-	-	-	-	-	-	-	-	-	-	CDP-OH_P_transf
HKD3_k127_432654_7	927677.ALVU02000001_gene4017	3.311e-56	209.0	COG4589@1|root,COG4589@2|Bacteria,1GCQF@1117|Cyanobacteria	1117|Cyanobacteria	S	Belongs to the CDS family	-	-	2.7.7.41	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_1
HKD3_k127_432654_8	1054213.HMPREF9946_00676	4.707e-41	164.0	COG0204@1|root,COG0204@2|Bacteria	2|Bacteria	I	Acyl-transferase	-	-	2.3.1.51,6.2.1.3	ko:K00655,ko:K01897	ko00061,ko00071,ko00561,ko00564,ko01100,ko01110,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map00561,map00564,map01100,map01110,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086,M00089	R01280,R02241,R09381	RC00004,RC00014,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C,Acyltransferase,NAD_binding_4,PP-binding,Sterile
HKD3_k127_432654_1	1122135.KB893134_gene3337	1.857e-186	599.0	COG2267@1|root,COG2267@2|Bacteria,1MWF5@1224|Proteobacteria	1224|Proteobacteria	I	Alpha beta hydrolase	ynbC	GO:0003674,GO:0003824,GO:0005575,GO:0006629,GO:0008150,GO:0008152,GO:0016020,GO:0016298,GO:0016787,GO:0016788,GO:0044238,GO:0071704	-	-	-	-	-	-	-	-	-	-	Hydrolase_4,Methyltransf_20
HKD3_k127_432654_4	1226994.AMZB01000134_gene4571	3.15e-73	264.0	COG0671@1|root,COG2453@1|root,COG0671@2|Bacteria,COG2453@2|Bacteria,1QSUD@1224|Proteobacteria,1RQAC@1236|Gammaproteobacteria,1YDPJ@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	IT	Dual specificity phosphatase, catalytic domain	ynbD	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	3.1.3.16	ko:K01090	-	-	-	-	ko00000,ko01000	-	-	-	DAGK_cat,DSPc,PAP2_3
HKD3_k127_432654_9	497964.CfE428DRAFT_3136	1.935e-26	113.0	2FFTB@1|root,347QG@2|Bacteria,46W3C@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_432654_2	2074.JNYD01000015_gene4604	9.549e-125	421.0	COG3848@1|root,COG3848@2|Bacteria,2H2J1@201174|Actinobacteria	201174|Actinobacteria	T	PEP-utilising enzyme, mobile domain	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers
HKD3_k127_432654_5	68223.JNZY01000062_gene1107	1.487e-68	248.0	COG0574@1|root,COG0574@2|Bacteria,2IJCV@201174|Actinobacteria	201174|Actinobacteria	G	Pyruvate phosphate dikinase, PEP/pyruvate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	PPDK_N
HKD3_k127_432654_12	926569.ANT_10990	9.106e-17	93.0	COG0664@1|root,COG0664@2|Bacteria,2G92E@200795|Chloroflexi	200795|Chloroflexi	T	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
HKD3_k127_4341953_2	478741.JAFS01000002_gene375	1.909e-31	124.0	COG0133@1|root,COG0133@2|Bacteria,46SHR@74201|Verrucomicrobia,37G1U@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB	-	4.2.1.20	ko:K01696	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HKD3_k127_4341953_1	204669.Acid345_1160	4.756e-71	252.0	COG0159@1|root,COG0159@2|Bacteria,3Y3X2@57723|Acidobacteria,2JI7C@204432|Acidobacteriia	204432|Acidobacteriia	E	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate	trpA	-	4.2.1.20	ko:K01695	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_syntA
HKD3_k127_4341953_0	649638.Trad_1102	6.812e-184	586.0	COG1233@1|root,COG1233@2|Bacteria,1WM3K@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	Q	Thi4 family	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_8
HKD3_k127_4419964_4	1267533.KB906733_gene2975	3.852e-55	198.0	COG4447@1|root,COG4447@2|Bacteria	2|Bacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	PSII_BNR
HKD3_k127_4419964_1	1123278.KB893477_gene3638	2.707e-95	320.0	COG3000@1|root,COG3000@2|Bacteria,4NES7@976|Bacteroidetes,47PZF@768503|Cytophagia	976|Bacteroidetes	I	Fatty acid hydroxylase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	FA_hydroxylase
HKD3_k127_4419964_0	866536.Belba_1144	5.843e-96	323.0	COG1305@1|root,COG1305@2|Bacteria,4NKII@976|Bacteroidetes,47KZ3@768503|Cytophagia	976|Bacteroidetes	E	Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Transglut_core
HKD3_k127_4419964_8	643867.Ftrac_0650	3.107e-31	128.0	COG1305@1|root,COG1305@2|Bacteria,4NKII@976|Bacteroidetes,47KZ3@768503|Cytophagia	976|Bacteroidetes	E	Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Transglut_core
HKD3_k127_4419964_5	370438.PTH_0128	2.127e-39	157.0	COG1216@1|root,COG1216@2|Bacteria,1UJRW@1239|Firmicutes,25F86@186801|Clostridia,262I4@186807|Peptococcaceae	186801|Clostridia	S	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HKD3_k127_4419964_2	497964.CfE428DRAFT_2062	2.21e-89	301.0	COG0854@1|root,COG0854@2|Bacteria,46SJT@74201|Verrucomicrobia	74201|Verrucomicrobia	H	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate	pdxJ	-	2.6.99.2	ko:K03474	ko00750,ko01100,map00750,map01100	M00124	R05838	RC01476	ko00000,ko00001,ko00002,ko01000	-	-	-	PdxJ
HKD3_k127_4419964_6	1396141.BATP01000013_gene2682	5.287e-36	140.0	COG0736@1|root,COG0736@2|Bacteria,46T5U@74201|Verrucomicrobia,2IUTE@203494|Verrucomicrobiae	203494|Verrucomicrobiae	I	4'-phosphopantetheinyl transferase superfamily	acpS	-	2.7.8.7	ko:K00997	ko00770,map00770	-	R01625	RC00002	ko00000,ko00001,ko01000	-	-	-	ACPS
HKD3_k127_4419964_7	522306.CAP2UW1_1519	1.044e-31	127.0	COG4828@1|root,COG4828@2|Bacteria,1N984@1224|Proteobacteria,2W60I@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Protein of unknown function (DUF1622)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1622
HKD3_k127_4419964_10	671143.DAMO_1907	3.426e-26	112.0	COG2372@1|root,COG2372@2|Bacteria	2|Bacteria	C	response to copper ion	-	-	-	ko:K07156,ko:K14166	-	-	-	-	ko00000,ko02000	9.B.62.2	-	-	CopC,CopD
HKD3_k127_4419964_3	1040989.AWZU01000003_gene6761	7.631e-83	285.0	28HTF@1|root,2Z80A@2|Bacteria,1PEXH@1224|Proteobacteria,2TTDP@28211|Alphaproteobacteria,3JWDE@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_4419964_11	864051.BurJ1DRAFT_1279	9.449e-18	94.0	2AJKK@1|root,31A7Q@2|Bacteria,1N0ZI@1224|Proteobacteria,2VXXW@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Methyltransferase FkbM domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_21
HKD3_k127_4419964_9	497964.CfE428DRAFT_2704	2.708e-28	120.0	COG1538@1|root,COG1538@2|Bacteria	2|Bacteria	MU	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	OEP
HKD3_k127_442900_14	1267533.KB906742_gene785	1.521e-05	52.0	COG5563@1|root,COG5563@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_442900_3	266117.Rxyl_0136	9.175e-104	356.0	COG1167@1|root,COG1167@2|Bacteria,2GJ5P@201174|Actinobacteria,4CQ4C@84995|Rubrobacteria	84995|Rubrobacteria	K	aminotransferase class I and II	-	-	-	ko:K00375	-	-	-	-	ko00000,ko03000	-	-	-	Aminotran_1_2,GntR
HKD3_k127_442900_6	452637.Oter_0661	2.693e-53	191.0	29XGP@1|root,30J79@2|Bacteria,46XI5@74201|Verrucomicrobia,3K9V9@414999|Opitutae	414999|Opitutae	S	Domain of unknown function (DUF5069)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5069
HKD3_k127_442900_0	1227457.C451_12270	3.849e-163	527.0	COG2041@1|root,arCOG00266@2157|Archaea,2Y7J0@28890|Euryarchaeota,240T4@183963|Halobacteria	183963|Halobacteria	S	COG4117 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein)	-	-	-	-	-	-	-	-	-	-	-	-	Ni_hydr_CYTB,Oxidored_molyb
HKD3_k127_442900_8	928210.CALU01000057_gene333	1.221e-21	97.0	2E4EA@1|root,32Z9I@2|Bacteria,1PWSF@1224|Proteobacteria,2V587@28211|Alphaproteobacteria,48UAE@772|Bartonellaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_442900_9	498761.HM1_3149	1.533e-19	91.0	2DMNG@1|root,32SP1@2|Bacteria,1VAXC@1239|Firmicutes,24P9Q@186801|Clostridia	186801|Clostridia	S	COG NOG14552 non supervised orthologous group	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_442900_12	927677.ALVU02000001_gene2649	2.306e-12	68.0	2EK6X@1|root,33DXA@2|Bacteria,1GFHH@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_442900_7	941770.GL622179_gene415	9.633e-25	104.0	2DN97@1|root,32W7A@2|Bacteria,1VANB@1239|Firmicutes,4HYZ4@91061|Bacilli,3F78H@33958|Lactobacillaceae	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_442900_11	748671.LCRIS_01652	2.379e-14	76.0	2DPM9@1|root,332MQ@2|Bacteria,1VGFB@1239|Firmicutes	1239|Firmicutes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_442900_13	3880.AES92424	1.411e-08	56.0	2DSTA@1|root,2S6GN@2759|Eukaryota,37W7A@33090|Viridiplantae,3GK4J@35493|Streptophyta	35493|Streptophyta	S	Protein of unknown function (DUF2647)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2647
HKD3_k127_442900_10	1380408.AVGH01000044_gene1352	3.988e-16	81.0	2DSQW@1|root,33H3S@2|Bacteria,1VP4J@1239|Firmicutes,4HSVH@91061|Bacilli	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_442900_5	344747.PM8797T_14489	5.651e-59	209.0	COG1670@1|root,COG1670@2|Bacteria	2|Bacteria	J	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins	-	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Acetyltransf_3
HKD3_k127_442900_4	1122132.AQYH01000019_gene321	3.032e-60	212.0	COG3865@1|root,COG3865@2|Bacteria,1N7IY@1224|Proteobacteria,2U993@28211|Alphaproteobacteria,4BFSP@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	3-demethylubiquinone-9 3-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	3-dmu-9_3-mt
HKD3_k127_442900_1	263820.PTO1360	2.495e-128	433.0	COG0674@1|root,arCOG01606@2157|Archaea,2XSUJ@28890|Euryarchaeota,241S7@183967|Thermoplasmata	183967|Thermoplasmata	C	Pyruvate:ferredoxin oxidoreductase core domain II	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR,POR_N
HKD3_k127_442900_2	1267534.KB906759_gene1729	1.802e-111	366.0	COG1013@1|root,COG1013@2|Bacteria,3Y3NE@57723|Acidobacteria,2JIEM@204432|Acidobacteriia	2|Bacteria	C	Pyruvate ferredoxin oxidoreductase beta subunit C terminal	porB	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFO_beta_C,TPP_enzyme_C
HKD3_k127_4472755_0	1040983.AXAE01000023_gene23	2.811e-243	762.0	COG0459@1|root,COG0459@2|Bacteria,1PMNK@1224|Proteobacteria,2TTPT@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	-	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0016465,GO:0032991,GO:0044183,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051082,GO:0061077,GO:0101031,GO:1990220	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
HKD3_k127_4472755_5	1479237.JMLY01000001_gene2639	7.518e-27	118.0	COG0517@1|root,COG0517@2|Bacteria,1QTVM@1224|Proteobacteria,1SFWU@1236|Gammaproteobacteria,46BCN@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
HKD3_k127_4472755_2	643473.KB235930_gene2821	1.939e-37	148.0	COG5502@1|root,COG5502@2|Bacteria,1G7AK@1117|Cyanobacteria,1HN9D@1161|Nostocales	1117|Cyanobacteria	S	Uncharacterized conserved protein (DUF2267)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2267
HKD3_k127_4472755_6	1537917.JU82_01515	5.984e-06	53.0	2EG21@1|root,339U1@2|Bacteria,1P2NF@1224|Proteobacteria,42X8D@68525|delta/epsilon subdivisions,2YQRR@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	S	Protein required for attachment to host cells	-	-	-	-	-	-	-	-	-	-	-	-	Host_attach
HKD3_k127_4472755_4	485913.Krac_9825	9.114e-33	128.0	2DJKR@1|root,32YT5@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_4472755_3	330214.NIDE1927	2.579e-35	148.0	COG0589@1|root,COG0589@2|Bacteria,3J1A7@40117|Nitrospirae	40117|Nitrospirae	T	Belongs to the universal stress protein A family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD3_k127_4472755_1	313624.NSP_38100	8.287e-127	412.0	COG2312@1|root,COG2312@2|Bacteria,1GK9Y@1117|Cyanobacteria,1HMEE@1161|Nostocales	1117|Cyanobacteria	S	Erythromycin esterase	-	-	-	-	-	-	-	-	-	-	-	-	Erythro_esteras
HKD3_k127_4499630_12	694427.Palpr_1101	8.64e-10	64.0	COG1055@1|root,COG1055@2|Bacteria,4NGWD@976|Bacteroidetes,2FX78@200643|Bacteroidia,22Z3H@171551|Porphyromonadaceae	976|Bacteroidetes	P	Putative citrate transport	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS_2
HKD3_k127_4499630_7	481448.Minf_0133	1.12e-65	239.0	COG2265@1|root,COG2265@2|Bacteria,46SYJ@74201|Verrucomicrobia,37H2T@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	H	tRNA (Uracil-5-)-methyltransferase	trmA	-	2.1.1.190,2.1.1.35	ko:K03215,ko:K15331	-	-	-	-	ko00000,ko01000,ko03009,ko03016	-	-	-	TRAM,tRNA_U5-meth_tr
HKD3_k127_4499630_10	497964.CfE428DRAFT_6193	3.975e-34	135.0	2FCQS@1|root,344TZ@2|Bacteria,46W38@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_4499630_6	1183438.GKIL_3827	1.218e-87	300.0	COG0861@1|root,COG0861@2|Bacteria	2|Bacteria	P	Integral membrane protein TerC family	alx	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K05794	-	-	-	-	ko00000	-	-	-	TerC
HKD3_k127_4499630_1	497964.CfE428DRAFT_3635	1.004e-176	573.0	COG0782@1|root,COG1747@1|root,COG0782@2|Bacteria,COG1747@2|Bacteria,46S7F@74201|Verrucomicrobia	74201|Verrucomicrobia	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides	greA	-	-	-	-	-	-	-	-	-	-	-	GreA_GreB,GreA_GreB_N
HKD3_k127_4499630_5	497964.CfE428DRAFT_3657	7.573e-92	308.0	COG1385@1|root,COG1385@2|Bacteria,46SZQ@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit	-	-	2.1.1.193	ko:K09761	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_RNA
HKD3_k127_4499630_4	204669.Acid345_1427	9.993e-102	339.0	COG0119@1|root,COG0119@2|Bacteria,3Y2NJ@57723|Acidobacteria,2JI67@204432|Acidobacteriia	204432|Acidobacteriia	E	HMGL-like	-	-	4.1.3.4	ko:K01640	ko00072,ko00280,ko00281,ko00650,ko01100,ko04146,map00072,map00280,map00281,map00650,map01100,map04146	M00036,M00088	R01360,R08090	RC00502,RC00503,RC01118,RC01946	ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like
HKD3_k127_4499630_3	382464.ABSI01000010_gene3750	1.178e-143	464.0	COG0484@1|root,COG0484@2|Bacteria,46TKC@74201|Verrucomicrobia,2ITUR@203494|Verrucomicrobiae	203494|Verrucomicrobiae	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
HKD3_k127_4499630_8	497964.CfE428DRAFT_3654	7.131e-47	175.0	COG0576@1|root,COG0576@2|Bacteria,46T79@74201|Verrucomicrobia	74201|Verrucomicrobia	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	grpE	-	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
HKD3_k127_4499630_2	497964.CfE428DRAFT_3653	2.514e-160	519.0	COG2208@1|root,COG2208@2|Bacteria,46SWK@74201|Verrucomicrobia	74201|Verrucomicrobia	T	Sigma factor PP2C-like phosphatases	rsbU	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	GAF_2,PAS_3,SpoIIE
HKD3_k127_4499630_9	497964.CfE428DRAFT_3652	7.238e-47	175.0	COG1366@1|root,COG1366@2|Bacteria,46T4Z@74201|Verrucomicrobia	74201|Verrucomicrobia	T	PFAM Sulfate transporter antisigma-factor antagonist STAS	rsbS	-	-	-	-	-	-	-	-	-	-	-	STAS
HKD3_k127_4499630_11	497964.CfE428DRAFT_3651	3.709e-32	134.0	2EMM1@1|root,33F9E@2|Bacteria,46TBT@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_4499630_0	497964.CfE428DRAFT_3647	0.0	1039.0	COG1236@1|root,COG1793@1|root,COG1236@2|Bacteria,COG1793@2|Bacteria,46SCR@74201|Verrucomicrobia	74201|Verrucomicrobia	L	DNA ligase N terminus	-	-	6.5.1.1,6.5.1.6,6.5.1.7	ko:K07577,ko:K10747	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00381,R00382,R10822,R10823	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,DNA_ligase_A_N,RMMBL
HKD3_k127_4546102_3	234267.Acid_0572	7.424e-23	100.0	2EAHU@1|root,334M0@2|Bacteria,3Y5JU@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_4546102_1	234267.Acid_7941	2.697e-153	497.0	COG0076@1|root,COG0076@2|Bacteria,3Y3S7@57723|Acidobacteria	57723|Acidobacteria	E	Pyridoxal-dependent decarboxylase conserved domain	-	-	-	-	-	-	-	-	-	-	-	-	Pyridoxal_deC
HKD3_k127_4546102_5	1163408.UU9_00909	1.116e-07	53.0	2EC7F@1|root,33660@2|Bacteria,1N839@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_4546102_2	1122604.JONR01000031_gene1279	2.392e-136	462.0	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1T5SE@1236|Gammaproteobacteria,1XDE6@135614|Xanthomonadales	135614|Xanthomonadales	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_19
HKD3_k127_4546102_0	1500894.JQNN01000001_gene1657	1.081e-238	750.0	COG4805@1|root,COG4805@2|Bacteria,1MUBX@1224|Proteobacteria,2W0VY@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Bacterial protein of unknown function (DUF885)	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
HKD3_k127_4546102_4	497964.CfE428DRAFT_3344	3.194e-13	72.0	COG1204@1|root,COG1204@2|Bacteria,46SCW@74201|Verrucomicrobia	74201|Verrucomicrobia	L	DEAD DEAH box helicase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DEAD,Helicase_C
HKD3_k127_4549124_0	1266925.JHVX01000007_gene2261	2.902e-89	311.0	COG0642@1|root,COG2205@2|Bacteria,1MW8M@1224|Proteobacteria,2WGGV@28216|Betaproteobacteria,373PP@32003|Nitrosomonadales	28216|Betaproteobacteria	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	copS	-	2.7.13.3	ko:K07644	ko02020,map02020	M00452,M00745	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko01504,ko02022	-	-	-	HAMP,HATPase_c,HisKA
HKD3_k127_4549124_1	1123508.JH636444_gene5245	3.207e-84	285.0	COG0745@1|root,COG0745@2|Bacteria,2IYM1@203682|Planctomycetes	203682|Planctomycetes	T	Transcriptional regulatory protein, C terminal	-	-	-	ko:K07665	ko02020,map02020	M00452,M00745	-	-	ko00000,ko00001,ko00002,ko01504,ko02022	-	-	-	Response_reg,Trans_reg_C
HKD3_k127_4549124_3	1382356.JQMP01000003_gene1646	1.031e-06	59.0	COG4243@1|root,COG4243@2|Bacteria,2G9QC@200795|Chloroflexi,27YHV@189775|Thermomicrobia	189775|Thermomicrobia	S	VKc	-	-	-	-	-	-	-	-	-	-	-	-	VKOR
HKD3_k127_4549124_2	497964.CfE428DRAFT_0533	6.823e-48	175.0	2DNV7@1|root,32ZAW@2|Bacteria	2|Bacteria	S	PD-(D/E)XK nuclease superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_3
HKD3_k127_4582787_0	886293.Sinac_3949	1.75e-77	273.0	2DP3M@1|root,330DW@2|Bacteria,2J0YX@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_4582787_2	1408437.JNJN01000010_gene1243	2.222e-21	99.0	COG1724@1|root,COG1724@2|Bacteria,1VGTK@1239|Firmicutes,24SD9@186801|Clostridia	186801|Clostridia	N	mRNA binding	-	-	-	-	-	-	-	-	-	-	-	-	HicA_toxin
HKD3_k127_4582787_1	1269813.ATUL01000015_gene113	1.09e-31	124.0	COG1598@1|root,COG1598@2|Bacteria,1NCC0@1224|Proteobacteria,1SFWT@1236|Gammaproteobacteria,1X1FT@135613|Chromatiales	135613|Chromatiales	S	HicB_like antitoxin of bacterial toxin-antitoxin system	-	-	-	-	-	-	-	-	-	-	-	-	HicB_lk_antitox
HKD3_k127_465382_10	316067.Geob_0124	1.393e-45	168.0	COG1290@1|root,COG1290@2|Bacteria,1N4ZV@1224|Proteobacteria,42TYE@68525|delta/epsilon subdivisions,2WQDQ@28221|Deltaproteobacteria,43UTS@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Cytochrome b(C-terminal)/b6/petD	pcmD	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_B_C
HKD3_k127_465382_8	671143.DAMO_0769	1.05e-59	224.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	pcmF	-	-	ko:K02305	ko00910,ko01120,map00910,map01120	M00529	R00294	RC02794	ko00000,ko00001,ko00002	3.D.4.10	-	-	Cytochrom_C,Cytochrome_CBB3
HKD3_k127_465382_18	523791.Kkor_1288	8.052e-08	64.0	COG2010@1|root,COG2010@2|Bacteria,1RFJV@1224|Proteobacteria,1S4GY@1236|Gammaproteobacteria,1XPKF@135619|Oceanospirillales	135619|Oceanospirillales	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C
HKD3_k127_465382_14	1379698.RBG1_1C00001G0781	1.014e-17	89.0	COG0723@1|root,COG0723@2|Bacteria,2NQ46@2323|unclassified Bacteria	2|Bacteria	C	Rieske [2Fe-2S] domain	petA	-	1.10.2.2,1.10.9.1	ko:K00411,ko:K02636,ko:K03886	ko00190,ko00195,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map00195,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152,M00162	R03817,R08409	RC01002	ko00000,ko00001,ko00002,ko00194,ko01000	-	-	iAF987.Gmet_1922	CytB6-F_Fe-S,Rieske,UCR_Fe-S_N
HKD3_k127_465382_2	1379698.RBG1_1C00001G0780	1.063e-106	361.0	COG1290@1|root,COG1290@2|Bacteria,2NP8C@2323|unclassified Bacteria	2|Bacteria	C	Cytochrome b(N-terminal)/b6/petB	petB	-	-	ko:K00410,ko:K00412,ko:K02635,ko:K02637	ko00190,ko00195,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map00195,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152,M00162	-	-	ko00000,ko00001,ko00002,ko00194,ko03029	-	-	-	Cytochrom_B_C,Cytochrom_C1,Cytochrome_B
HKD3_k127_465382_6	1379698.RBG1_1C00001G0779	1.437e-71	265.0	COG2864@1|root,COG2864@2|Bacteria,2NQBN@2323|unclassified Bacteria	2|Bacteria	C	Cytochrome c554 and c-prime	-	-	-	ko:K03620	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	Cytochrom_c3_2,Cytochrome_C554,Ni_hydr_CYTB
HKD3_k127_465382_9	638303.Thal_1573	7.959e-47	179.0	COG1622@1|root,COG1622@2|Bacteria	2|Bacteria	C	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor	cbaB	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2,COX2-transmemb
HKD3_k127_465382_17	869210.Marky_2012	1.515e-15	87.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	soxX	-	1.9.3.1	ko:K02275,ko:K17223	ko00190,ko00920,ko01100,ko01120,map00190,map00920,map01100,map01120	M00155,M00595	R00081,R10151	RC00016,RC03151,RC03152	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	Cytochrom_C
HKD3_k127_465382_0	925409.KI911562_gene954	8.093e-206	654.0	COG0843@1|root,COG0843@2|Bacteria,4P06K@976|Bacteroidetes	976|Bacteroidetes	C	Cytochrome C oxidase subunit I	-	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
HKD3_k127_465382_16	224324.aq_2194	4.143e-17	90.0	COG1999@1|root,COG1999@2|Bacteria	2|Bacteria	M	signal sequence binding	-	-	-	ko:K07152	-	-	-	-	ko00000,ko03029	-	-	-	SCO1-SenC
HKD3_k127_465382_4	1396141.BATP01000039_gene1324	2.559e-89	301.0	COG1611@1|root,COG1611@2|Bacteria,46SEG@74201|Verrucomicrobia,2ITGC@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Possible lysine decarboxylase	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
HKD3_k127_465382_13	1191523.MROS_2770	6.036e-25	112.0	COG0589@1|root,COG0589@2|Bacteria	2|Bacteria	T	AMP binding	usp-3	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD3_k127_465382_11	247490.KSU1_A0074	2.568e-36	146.0	COG0664@1|root,COG0664@2|Bacteria,2J0N9@203682|Planctomycetes	203682|Planctomycetes	T	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
HKD3_k127_465382_5	497964.CfE428DRAFT_3249	1.616e-84	289.0	COG2169@1|root,COG4936@1|root,COG2169@2|Bacteria,COG4936@2|Bacteria,46UZR@74201|Verrucomicrobia	74201|Verrucomicrobia	K	PFAM helix-turn-helix- domain containing protein AraC type	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18,PocR
HKD3_k127_465382_3	118163.Ple7327_1621	2.829e-93	315.0	COG0462@1|root,COG0462@2|Bacteria,1G00F@1117|Cyanobacteria,3VHW2@52604|Pleurocapsales	1117|Cyanobacteria	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	-	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyl_synth,Pribosyltran_N
HKD3_k127_465382_1	670292.JH26_17415	2.231e-148	479.0	COG1690@1|root,COG1690@2|Bacteria,1MUHA@1224|Proteobacteria,2U2PN@28211|Alphaproteobacteria,1JWZ2@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	tRNA-splicing ligase RtcB	-	-	6.5.1.3	ko:K14415	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RtcB
HKD3_k127_465382_15	1292034.OR37_02619	2.884e-17	95.0	COG3591@1|root,COG3591@2|Bacteria,1R9P2@1224|Proteobacteria,2U37F@28211|Alphaproteobacteria,2KF5Z@204458|Caulobacterales	204458|Caulobacterales	E	Trypsin-like peptidase domain	-	-	-	-	-	-	-	-	-	-	-	-	Trypsin_2
HKD3_k127_465382_7	118163.Ple7327_0398	1.264e-65	233.0	COG1926@1|root,COG1926@2|Bacteria,1G2IS@1117|Cyanobacteria,3VJI1@52604|Pleurocapsales	1117|Cyanobacteria	S	PFAM Phosphoribosyl transferase domain	-	-	-	ko:K07100	-	-	-	-	ko00000	-	-	-	Pribosyltran
HKD3_k127_465382_12	330214.NIDE1927	1.616e-33	143.0	COG0589@1|root,COG0589@2|Bacteria,3J1A7@40117|Nitrospirae	40117|Nitrospirae	T	Belongs to the universal stress protein A family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD3_k127_465382_19	404589.Anae109_3093	0.0001541	48.0	COG0589@1|root,COG0589@2|Bacteria,1MVZS@1224|Proteobacteria,42QGY@68525|delta/epsilon subdivisions,2WKHR@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Universal stress protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD3_k127_4703204_0	204669.Acid345_1384	1.188e-289	898.0	COG1053@1|root,COG1053@2|Bacteria,3Y6IU@57723|Acidobacteria,2JKAD@204432|Acidobacteriia	204432|Acidobacteriia	C	Fumarate reductase flavoprotein C-term	-	-	1.3.5.1,1.3.5.4	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
HKD3_k127_4703204_3	1210884.HG799466_gene12570	7.281e-120	389.0	2CEY7@1|root,2Z8CG@2|Bacteria	2|Bacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_4703204_1	525897.Dbac_1167	8.27e-215	675.0	COG0491@1|root,COG0607@1|root,COG0491@2|Bacteria,COG0607@2|Bacteria,1MUDN@1224|Proteobacteria,42N3H@68525|delta/epsilon subdivisions,2WJSC@28221|Deltaproteobacteria,2MA27@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	Rhodanese domain protein	-	-	3.1.2.6	ko:K01069	ko00620,map00620	-	R01736	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	Lactamase_B,Rhodanese
HKD3_k127_4703204_4	1121381.JNIV01000020_gene3267	5.917e-117	387.0	COG2041@1|root,COG2041@2|Bacteria,1WI25@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	PFAM Mo-co oxidoreductase dimerisation domain	-	-	-	ko:K17225	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	-	-	-	Mo-co_dimer,Oxidored_molyb
HKD3_k127_4703204_6	1210884.HG799468_gene13549	8.844e-16	82.0	COG2140@1|root,COG2140@2|Bacteria,2IWYT@203682|Planctomycetes	203682|Planctomycetes	G	Cupin	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_1
HKD3_k127_4703204_2	84531.JMTZ01000094_gene649	2.538e-213	672.0	COG1228@1|root,COG1228@2|Bacteria,1MY4V@1224|Proteobacteria,1RZRK@1236|Gammaproteobacteria,1X4X1@135614|Xanthomonadales	135614|Xanthomonadales	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
HKD3_k127_4703204_5	84531.JMTZ01000094_gene649	1.753e-43	164.0	COG1228@1|root,COG1228@2|Bacteria,1MY4V@1224|Proteobacteria,1RZRK@1236|Gammaproteobacteria,1X4X1@135614|Xanthomonadales	135614|Xanthomonadales	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
HKD3_k127_4703204_7	1396418.BATQ01000142_gene3310	1.798e-12	78.0	2DFF9@1|root,2ZRMT@2|Bacteria	2|Bacteria	S	Putative peptidoglycan binding domain	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_1
HKD3_k127_4703204_8	717785.HYPMC_0530	0.0004512	44.0	2DT3B@1|root,33IHT@2|Bacteria,1NK4F@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_4717919_1	497964.CfE428DRAFT_1374	9.314e-40	162.0	COG0582@1|root,COG0582@2|Bacteria	2|Bacteria	L	DNA integration	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	Phage_int_SAM_3,Phage_integrase
HKD3_k127_4717919_0	322710.Avin_07960	5.586e-69	236.0	COG1064@1|root,COG1064@2|Bacteria,1MUTT@1224|Proteobacteria,1RPQC@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	alcohol dehydrogenase	adhP	-	1.1.1.1	ko:K00001,ko:K13953	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
HKD3_k127_4757199_1	344747.PM8797T_23029	3.52e-222	698.0	COG1640@1|root,COG1640@2|Bacteria,2IXJJ@203682|Planctomycetes	203682|Planctomycetes	G	4-alpha-glucanotransferase	-	-	2.4.1.25	ko:K00705	ko00500,ko01100,map00500,map01100	-	R05196	RC00049	ko00000,ko00001,ko01000	-	GH77	-	Glyco_hydro_77
HKD3_k127_4757199_0	1232410.KI421426_gene1491	8.681e-294	908.0	COG0166@1|root,COG0166@2|Bacteria,1MUFP@1224|Proteobacteria,42MNB@68525|delta/epsilon subdivisions,2WJ0I@28221|Deltaproteobacteria,43S3J@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Phosphoglucose isomerase	pgi	-	5.3.1.9	ko:K01810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114	R02739,R02740,R03321	RC00376,RC00563	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGI
HKD3_k127_4757199_2	1122247.C731_2458	3.317e-56	198.0	COG3588@1|root,COG3588@2|Bacteria,2GN1A@201174|Actinobacteria,233KA@1762|Mycobacteriaceae	201174|Actinobacteria	G	Aldolase	fda	-	4.1.2.13	ko:K01623	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000,ko03036,ko04131,ko04147	-	-	-	Glycolytic
HKD3_k127_4853809_0	497964.CfE428DRAFT_4177	1.538e-202	637.0	COG0334@1|root,COG0334@2|Bacteria,46S9K@74201|Verrucomicrobia	74201|Verrucomicrobia	C	Belongs to the Glu Leu Phe Val dehydrogenases family	gdhA	-	1.4.1.3	ko:K00261	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
HKD3_k127_4853809_4	334390.LAF_0901	9.337e-18	94.0	COG2017@1|root,COG2017@2|Bacteria,1U26T@1239|Firmicutes,4HA4J@91061|Bacilli,3F3KT@33958|Lactobacillaceae	91061|Bacilli	G	Aldose 1-epimerase	lacX	-	5.1.3.3	ko:K01785	ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130	M00632	R01602,R10619	RC00563	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldose_epim
HKD3_k127_4853809_3	240015.ACP_0684	4.068e-41	158.0	COG2020@1|root,COG2020@2|Bacteria,3Y55R@57723|Acidobacteria,2JJVJ@204432|Acidobacteriia	204432|Acidobacteriia	O	Isoprenylcysteine carboxyl methyltransferase (ICMT) family	-	-	2.1.1.100	ko:K00587	ko00900,ko01130,map00900,map01130	-	R04496	RC00003,RC00460	ko00000,ko00001,ko01000	-	-	-	PEMT
HKD3_k127_4853809_2	1118054.CAGW01000053_gene1387	2.725e-57	211.0	COG0124@1|root,COG0124@2|Bacteria,1VSV5@1239|Firmicutes,4HUZY@91061|Bacilli,26WA6@186822|Paenibacillaceae	91061|Bacilli	J	histidyl-tRNA synthetase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_4853809_1	1118054.CAGW01000053_gene1386	7.592e-120	390.0	COG0179@1|root,COG0179@2|Bacteria,1VRIW@1239|Firmicutes,4HUFK@91061|Bacilli,26U89@186822|Paenibacillaceae	91061|Bacilli	Q	Fumarylacetoacetase N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	FAA_hydrolase,FAA_hydrolase_N
HKD3_k127_4853886_3	485915.Dret_1750	1.164e-08	57.0	COG0021@1|root,COG0021@2|Bacteria	2|Bacteria	G	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_N,XFP,XFP_N
HKD3_k127_4853886_2	452637.Oter_0885	2.986e-66	235.0	COG0259@1|root,COG0259@2|Bacteria,46SRQ@74201|Verrucomicrobia,3K82F@414999|Opitutae	414999|Opitutae	H	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region	-	-	1.4.3.5	ko:K00275	ko00750,ko01100,ko01120,map00750,map01100,map01120	M00124	R00277,R00278,R01710,R01711	RC00048,RC00116	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_phzG_C,Putative_PNPOx
HKD3_k127_4853886_4	553177.CAPSP0001_0816	2.343e-07	56.0	COG0276@1|root,COG0276@2|Bacteria,4NE83@976|Bacteroidetes,1HXUV@117743|Flavobacteriia,1EQUF@1016|Capnocytophaga	976|Bacteroidetes	H	Belongs to the ferrochelatase family	hemH	-	4.99.1.1,4.99.1.9	ko:K01772	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R00310,R11329	RC01012	ko00000,ko00001,ko00002,ko01000	-	-	-	Ferrochelatase
HKD3_k127_4853886_0	76114.ebA4954	1.643e-238	744.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2VHNN@28216|Betaproteobacteria,2KVWA@206389|Rhodocyclales	206389|Rhodocyclales	C	Aldehyde dehydrogenase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldedh
HKD3_k127_4853886_1	1407650.BAUB01000005_gene1293	8.34e-186	588.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1145@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1145@2|Bacteria,1G2E2@1117|Cyanobacteria,1GZV7@1129|Synechococcus	1117|Cyanobacteria	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	nifJ	GO:0003674,GO:0003824,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0016491,GO:0050896,GO:0055114	1.2.7.1	ko:K03737	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00173,M00307	R01196,R10866	RC00004,RC02742	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iJN678.nifJ	EKR,Fer4_16,PFOR_II,POR,POR_N,TPP_enzyme_C
HKD3_k127_4869834_5	497964.CfE428DRAFT_4379	3.688e-39	151.0	COG1664@1|root,COG1664@2|Bacteria,46VS6@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Polymer-forming cytoskeletal	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
HKD3_k127_4869834_0	1396418.BATQ01000183_gene992	5.39e-297	923.0	COG1154@1|root,COG1154@2|Bacteria,46SAU@74201|Verrucomicrobia,2ITIS@203494|Verrucomicrobiae	203494|Verrucomicrobiae	HI	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)	dxs	-	2.2.1.7	ko:K01662	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	M00096	R05636	RC00032	ko00000,ko00001,ko00002,ko01000	-	-	-	DXP_synthase_N,Transket_pyr,Transketolase_C
HKD3_k127_4869834_6	497964.CfE428DRAFT_3285	2.013e-21	96.0	COG1722@1|root,COG1722@2|Bacteria,46TB2@74201|Verrucomicrobia	74201|Verrucomicrobia	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseB	-	3.1.11.6	ko:K03602	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_S
HKD3_k127_4869834_10	525904.Tter_1914	4.759e-16	87.0	COG4122@1|root,COG4122@2|Bacteria	2|Bacteria	E	O-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_24
HKD3_k127_4869834_4	1396141.BATP01000007_gene5666	5.868e-42	157.0	COG0509@1|root,COG0509@2|Bacteria,46VKU@74201|Verrucomicrobia,2IUJ1@203494|Verrucomicrobiae	203494|Verrucomicrobiae	E	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	gcvH	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
HKD3_k127_4869834_1	497964.CfE428DRAFT_2626	3.742e-126	420.0	COG0404@1|root,COG0404@2|Bacteria,46UPA@74201|Verrucomicrobia	74201|Verrucomicrobia	E	Glycine cleavage T-protein C-terminal barrel domain	gcvT	-	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	GCV_T,GCV_T_C
HKD3_k127_4869834_3	497964.CfE428DRAFT_2627	1.574e-88	299.0	COG0705@1|root,COG0705@2|Bacteria,46SY5@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Rhomboid family	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_4869834_2	1396141.BATP01000060_gene4688	4.356e-103	342.0	COG3253@1|root,COG3253@2|Bacteria,46SQD@74201|Verrucomicrobia,2IVHP@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Chlorite dismutase	-	-	-	-	-	-	-	-	-	-	-	-	Chlor_dismutase
HKD3_k127_4869834_11	1227500.C494_04346	1.415e-10	69.0	arCOG08193@1|root,arCOG08193@2157|Archaea,2XVQ3@28890|Euryarchaeota,23U2C@183963|Halobacteria	183963|Halobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_4869834_8	63737.Npun_R3135	2.187e-17	93.0	COG4319@1|root,COG4319@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440
HKD3_k127_4869834_7	1123392.AQWL01000003_gene262	2.9e-21	99.0	COG1073@1|root,COG2885@1|root,COG1073@2|Bacteria,COG2885@2|Bacteria,1RFNW@1224|Proteobacteria,2W31D@28216|Betaproteobacteria	28216|Betaproteobacteria	M	chlorophyll binding	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_4869834_9	1300345.LF41_1036	8.66e-17	87.0	2DSYW@1|root,33HZI@2|Bacteria,1NKP8@1224|Proteobacteria,1SISV@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_4869834_12	1235457.C404_16725	6.096e-10	66.0	COG0583@1|root,COG0583@2|Bacteria,1R55T@1224|Proteobacteria,2W0SM@28216|Betaproteobacteria,1K2JA@119060|Burkholderiaceae	28216|Betaproteobacteria	K	regulatory protein LysR	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HKD3_k127_4873433_4	1183438.GKIL_2987	5.755e-178	571.0	COG0308@1|root,COG0308@2|Bacteria,1G03V@1117|Cyanobacteria	1117|Cyanobacteria	CE	aminopeptidase N	pepN	-	3.4.11.2	ko:K01256	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	DUF3458,DUF3458_C,Peptidase_M1
HKD3_k127_4873433_30	497964.CfE428DRAFT_0894	3.947e-22	101.0	295MM@1|root,2ZSZ1@2|Bacteria,46WK9@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_4873433_13	497964.CfE428DRAFT_0896	4.513e-77	263.0	COG1595@1|root,COG1595@2|Bacteria,46V3R@74201|Verrucomicrobia	74201|Verrucomicrobia	K	ECF sigma factor	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD3_k127_4873433_14	497964.CfE428DRAFT_0897	4.034e-76	261.0	2BXAM@1|root,2ZPRA@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_4873433_16	497964.CfE428DRAFT_4443	7.872e-71	247.0	COG0561@1|root,COG0561@2|Bacteria,46SWT@74201|Verrucomicrobia	74201|Verrucomicrobia	S	haloacid dehalogenase-like hydrolase	cof	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_3
HKD3_k127_4873433_32	497964.CfE428DRAFT_4444	1.167e-19	92.0	28X6Y@1|root,2ZJ59@2|Bacteria,46WIZ@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_4873433_8	497964.CfE428DRAFT_1380	7.217e-134	435.0	COG3239@1|root,COG3239@2|Bacteria	2|Bacteria	I	unsaturated fatty acid biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	FA_desaturase
HKD3_k127_4873433_9	1156937.MFUM_870060	1.178e-127	417.0	COG0462@1|root,COG0462@2|Bacteria,46SVH@74201|Verrucomicrobia,37GGN@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	prs	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyl_synth,Pribosyltran_N
HKD3_k127_4873433_19	497964.CfE428DRAFT_1544	5.577e-62	223.0	COG1825@1|root,COG1825@2|Bacteria,46SZS@74201|Verrucomicrobia	74201|Verrucomicrobia	J	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance	ctc	-	-	ko:K02897	ko03010,map03010	M00178	-	-	ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L25p,Ribosomal_TL5_C
HKD3_k127_4873433_21	484770.UFO1_4295	1.178e-50	186.0	COG0193@1|root,COG0193@2|Bacteria,1V3NB@1239|Firmicutes,4H4AW@909932|Negativicutes	909932|Negativicutes	J	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis	pth	-	3.1.1.29	ko:K01056	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	Pept_tRNA_hydro
HKD3_k127_4873433_28	497964.CfE428DRAFT_1542	6.68e-30	121.0	COG0360@1|root,COG0360@2|Bacteria	2|Bacteria	J	Binds together with S18 to 16S ribosomal RNA	rpsF	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0019843,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070181,GO:0097159,GO:1901363,GO:1990904	-	ko:K02990	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S6
HKD3_k127_4873433_20	497964.CfE428DRAFT_1541	2.06e-54	194.0	COG0629@1|root,COG0629@2|Bacteria,46VGA@74201|Verrucomicrobia	74201|Verrucomicrobia	L	Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism	-	-	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
HKD3_k127_4873433_7	497964.CfE428DRAFT_5447	1.888e-144	466.0	COG0758@1|root,COG0758@2|Bacteria,46SGR@74201|Verrucomicrobia	74201|Verrucomicrobia	L	TIGRFAM DNA protecting protein DprA	smf	-	-	ko:K04096	-	-	-	-	ko00000	-	-	-	DNA_processg_A,HHH_5
HKD3_k127_4873433_0	76114.ebA2963	3.98e-288	913.0	COG0550@1|root,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,2VHUF@28216|Betaproteobacteria,2KUMN@206389|Rhodocyclales	206389|Rhodocyclales	L	DNA topoisomerase III	-	-	5.99.1.2	ko:K03169	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	Topoisom_bac,Toprim,Toprim_Crpt
HKD3_k127_4873433_15	455632.SGR_3841	4.921e-74	265.0	COG1520@1|root,COG1520@2|Bacteria,2GW3X@201174|Actinobacteria	201174|Actinobacteria	S	PQQ-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2,PQQ_3
HKD3_k127_4873433_29	1157490.EL26_07285	8.567e-27	123.0	COG0697@1|root,COG0697@2|Bacteria,1TSE2@1239|Firmicutes,4HBD2@91061|Bacilli,279DE@186823|Alicyclobacillaceae	91061|Bacilli	EG	EamA-like transporter family	yoaV3	-	-	-	-	-	-	-	-	-	-	-	EamA
HKD3_k127_4873433_24	1396418.BATQ01000106_gene5316	3.99e-46	172.0	COG1327@1|root,COG1327@2|Bacteria,46TAA@74201|Verrucomicrobia,2IU77@203494|Verrucomicrobiae	203494|Verrucomicrobiae	K	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes	nrdR	-	-	ko:K07738	-	-	-	-	ko00000,ko03000	-	-	-	ATP-cone
HKD3_k127_4873433_25	1123242.JH636435_gene1339	1.076e-40	155.0	COG0537@1|root,COG0537@2|Bacteria,2J045@203682|Planctomycetes	203682|Planctomycetes	FG	COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family	-	-	-	ko:K02503	-	-	-	-	ko00000,ko04147	-	-	-	HIT
HKD3_k127_4873433_34	1403819.BATR01000016_gene485	1.575e-16	83.0	2CK93@1|root,2ZJ73@2|Bacteria,46WK8@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_4873433_36	1396418.BATQ01000142_gene3284	4.377e-13	74.0	COG0291@1|root,COG0291@2|Bacteria,46TCI@74201|Verrucomicrobia,2IUW5@203494|Verrucomicrobiae	203494|Verrucomicrobiae	J	Ribosomal protein L35	-	-	-	ko:K02916	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L35p
HKD3_k127_4873433_6	1184267.A11Q_1776	5.309e-154	498.0	COG1252@1|root,COG1252@2|Bacteria,1MX96@1224|Proteobacteria,42PFG@68525|delta/epsilon subdivisions,2MSNE@213481|Bdellovibrionales,2WKPM@28221|Deltaproteobacteria	213481|Bdellovibrionales	C	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	1.6.99.3	ko:K03885	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
HKD3_k127_4873433_3	497964.CfE428DRAFT_2917	2.77e-199	629.0	COG0015@1|root,COG0015@2|Bacteria,46UUE@74201|Verrucomicrobia	74201|Verrucomicrobia	F	Adenylosuccinate lyase C-terminus	purB	-	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	-	ADSL_C,Lyase_1
HKD3_k127_4873433_17	497964.CfE428DRAFT_5674	2.231e-70	244.0	COG0586@1|root,COG0586@2|Bacteria,46SWW@74201|Verrucomicrobia	74201|Verrucomicrobia	S	SNARE associated Golgi protein	dedA	-	-	ko:K03975	-	-	-	-	ko00000	-	-	-	SNARE_assoc
HKD3_k127_4873433_2	497964.CfE428DRAFT_2919	1.15e-214	683.0	COG1132@1|root,COG1132@2|Bacteria,46SH3@74201|Verrucomicrobia	74201|Verrucomicrobia	V	ABC transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC_membrane,ABC_tran
HKD3_k127_4873433_18	497964.CfE428DRAFT_2920	3.154e-70	243.0	COG0110@1|root,COG0110@2|Bacteria,46T6H@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Hexapeptide repeat of succinyl-transferase	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep
HKD3_k127_4873433_5	497964.CfE428DRAFT_2921	4.249e-155	499.0	COG0438@1|root,COG0438@2|Bacteria,46VPZ@74201|Verrucomicrobia	74201|Verrucomicrobia	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_4873433_27	682795.AciX8_4415	3.694e-31	126.0	2DMEF@1|root,32QYK@2|Bacteria,3Y516@57723|Acidobacteria,2JJEQ@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_4873433_22	323097.Nham_2694	2.531e-49	180.0	COG1073@1|root,COG1765@1|root,COG1073@2|Bacteria,COG1765@2|Bacteria,1N2BT@1224|Proteobacteria,2TQN7@28211|Alphaproteobacteria,3JQSS@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	O	OsmC-like protein	MA20_16590	-	-	ko:K06889,ko:K07397	-	-	-	-	ko00000	-	-	-	Hydrolase_4,OsmC
HKD3_k127_4873433_23	382464.ABSI01000011_gene2994	3.299e-48	177.0	2DQ7E@1|root,3353C@2|Bacteria,46SU5@74201|Verrucomicrobia,2IUQR@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Domain of unknown function (DUF5069)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5069
HKD3_k127_4873433_33	497964.CfE428DRAFT_0798	2.553e-18	92.0	COG5637@1|root,COG5637@2|Bacteria,46W7X@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Polyketide cyclase / dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc
HKD3_k127_4873433_31	1356854.N007_14960	9.039e-20	105.0	COG2202@1|root,COG3852@1|root,COG2202@2|Bacteria,COG3852@2|Bacteria,1TRH0@1239|Firmicutes,4HD4A@91061|Bacilli,2799P@186823|Alicyclobacillaceae	91061|Bacilli	T	PAS fold	-	-	2.7.13.3	ko:K02491	ko02020,map02020	M00485	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	5TM-5TMR_LYT,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9
HKD3_k127_4873433_11	748247.AZKH_2519	3.801e-92	333.0	COG2203@1|root,COG4585@1|root,COG2203@2|Bacteria,COG4585@2|Bacteria,1R43J@1224|Proteobacteria,2VPEB@28216|Betaproteobacteria	28216|Betaproteobacteria	T	PFAM ATP-binding region, ATPase domain protein	-	-	2.7.13.3	ko:K02486	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	CHASE5,HAMP,HATPase_c,HisKA_3,PAS,PAS_4,PAS_8,PAS_9,Response_reg
HKD3_k127_4873433_12	1298858.AUEL01000019_gene3259	8.636e-79	269.0	COG2197@1|root,COG2197@2|Bacteria,1NQH7@1224|Proteobacteria,2VFHH@28211|Alphaproteobacteria,43RJV@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	T	helix_turn_helix, Lux Regulon	-	-	-	ko:K07684	ko02020,map02020	M00471	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	GerE,Response_reg
HKD3_k127_4873433_10	240016.ABIZ01000001_gene5812	2.226e-127	409.0	COG0426@1|root,COG0426@2|Bacteria,46UCH@74201|Verrucomicrobia,2IV55@203494|Verrucomicrobiae	203494|Verrucomicrobiae	C	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_4873433_38	748247.AZKH_2520	2.697e-06	53.0	COG2197@1|root,COG2197@2|Bacteria,1NQH7@1224|Proteobacteria,2VMXI@28216|Betaproteobacteria,2KWA5@206389|Rhodocyclales	206389|Rhodocyclales	K	helix_turn_helix, Lux Regulon	-	-	-	ko:K07684	ko02020,map02020	M00471	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	GerE,Response_reg
HKD3_k127_4873433_1	1267533.KB906738_gene2432	1.118e-280	872.0	COG0281@1|root,COG0281@2|Bacteria,3Y43V@57723|Acidobacteria,2JKSF@204432|Acidobacteriia	204432|Acidobacteriia	C	Malic enzyme, NAD binding domain	-	-	1.1.1.38	ko:K00027	ko00620,ko01200,ko02020,map00620,map01200,map02020	-	R00214	RC00105	ko00000,ko00001,ko01000	-	-	-	Malic_M,malic
HKD3_k127_4883675_12	118168.MC7420_1391	3.57e-36	143.0	COG0705@1|root,COG0705@2|Bacteria,1G1Z3@1117|Cyanobacteria,1H857@1150|Oscillatoriales	1117|Cyanobacteria	S	(Rhomboid) family	-	-	3.4.21.105	ko:K19225	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Rhomboid
HKD3_k127_4883675_0	243231.GSU0371	1.853e-259	825.0	COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,42MEQ@68525|delta/epsilon subdivisions,2WIPF@28221|Deltaproteobacteria,43T5A@69541|Desulfuromonadales	28221|Deltaproteobacteria	G	Protein of unknown function (DUF3417)	glgP	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	DUF3417,Phosphorylase
HKD3_k127_4883675_8	1209989.TepiRe1_2193	2.72e-70	251.0	COG2355@1|root,COG2355@2|Bacteria,1UA7M@1239|Firmicutes,24AE6@186801|Clostridia,42F00@68295|Thermoanaerobacterales	186801|Clostridia	E	PFAM Peptidase M19, renal dipeptidase	-	-	3.4.13.19	ko:K01273	-	-	-	-	ko00000,ko00537,ko01000,ko01002,ko04147	-	-	-	Peptidase_M19
HKD3_k127_4883675_11	595460.RRSWK_04758	6.182e-37	144.0	2E5WH@1|root,32RS6@2|Bacteria	2|Bacteria	J	23S rRNA-intervening sequence protein	-	-	-	-	-	-	-	-	-	-	-	-	23S_rRNA_IVP
HKD3_k127_4883675_6	1403819.BATR01000005_gene158	2.733e-133	439.0	COG1236@1|root,COG1236@2|Bacteria,46SQ0@74201|Verrucomicrobia,2ITW2@203494|Verrucomicrobiae	203494|Verrucomicrobiae	J	Beta-Casp domain	-	-	-	-	-	-	-	-	-	-	-	-	Beta-Casp,Lactamase_B,RMMBL
HKD3_k127_4883675_7	1242864.D187_008763	7.923e-89	300.0	COG0708@1|root,COG0708@2|Bacteria,1MVII@1224|Proteobacteria,42R8B@68525|delta/epsilon subdivisions,2X5KI@28221|Deltaproteobacteria,2YUUJ@29|Myxococcales	28221|Deltaproteobacteria	L	Endonuclease/Exonuclease/phosphatase family	xth	-	3.1.11.2	ko:K01142	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exo_endo_phos
HKD3_k127_4883675_5	670307.HYPDE_33213	3.025e-142	474.0	COG3011@1|root,COG3011@2|Bacteria,1N0MB@1224|Proteobacteria	1224|Proteobacteria	S	Lipase maturation factor	-	-	-	-	-	-	-	-	-	-	-	-	DUF393,LMF1
HKD3_k127_4883675_13	497964.CfE428DRAFT_2247	4.03e-30	120.0	COG0361@1|root,COG0361@2|Bacteria	2|Bacteria	J	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex	infA	GO:0001871,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0009986,GO:0030246,GO:0030247,GO:0043021,GO:0043022,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:2001065	-	ko:K02518	-	-	-	-	ko00000,ko03012	-	-	-	eIF-1a
HKD3_k127_4883675_14	497964.CfE428DRAFT_2246	1.358e-14	78.0	28ZM8@1|root,2ZMCH@2|Bacteria,46WY7@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Bacterial protein of unknown function (DUF883)	-	-	-	-	-	-	-	-	-	-	-	-	DUF883
HKD3_k127_4883675_3	497964.CfE428DRAFT_2243	1.027e-158	507.0	COG2805@1|root,COG2805@2|Bacteria,46UF2@74201|Verrucomicrobia	74201|Verrucomicrobia	NU	Type II/IV secretion system protein	-	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
HKD3_k127_4883675_2	497964.CfE428DRAFT_2241	5.749e-159	512.0	COG2805@1|root,COG2805@2|Bacteria,46SY2@74201|Verrucomicrobia	74201|Verrucomicrobia	NU	PFAM type II secretion system protein E	-	-	-	-	-	-	-	-	-	-	-	-	T2SSE
HKD3_k127_4883675_9	1183438.GKIL_0413	7.349e-61	226.0	COG2911@1|root,COG5295@1|root,COG2911@2|Bacteria,COG5295@2|Bacteria	2|Bacteria	UW	Hep Hag repeat protein	-	GO:0005575,GO:0005576	-	-	-	-	-	-	-	-	-	-	CBM_3,CHAT,CHU_C,Cohesin,Peptidase_S74
HKD3_k127_4883675_10	1123399.AQVE01000011_gene1258	4.257e-56	217.0	COG3209@1|root,COG5295@1|root,COG3209@2|Bacteria,COG5295@2|Bacteria,1N4WT@1224|Proteobacteria	1224|Proteobacteria	UW	cellulase activity	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S74
HKD3_k127_4883675_4	395965.Msil_2439	1.402e-143	463.0	COG1064@1|root,COG1064@2|Bacteria,1MUTT@1224|Proteobacteria,2TTI9@28211|Alphaproteobacteria,3NA6C@45404|Beijerinckiaceae	28211|Alphaproteobacteria	S	Alcohol dehydrogenase GroES-like domain	-	-	1.1.1.1	ko:K13953	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N_2
HKD3_k127_4883675_1	706587.Desti_1032	4.137e-215	687.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJ8D@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296,ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
HKD3_k127_4903367_2	228410.NE1590	1.046e-06	53.0	COG4691@1|root,COG4691@2|Bacteria,1N09T@1224|Proteobacteria,2VVBK@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Arc-like DNA binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Arc
HKD3_k127_4903367_1	522306.CAP2UW1_4442	4.817e-35	138.0	COG4113@1|root,COG4113@2|Bacteria,1RIR6@1224|Proteobacteria,2VSUI@28216|Betaproteobacteria	28216|Betaproteobacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
HKD3_k127_4903367_0	1396141.BATP01000003_gene5174	1.446e-41	156.0	COG0538@1|root,COG0538@2|Bacteria,46Z6W@74201|Verrucomicrobia,2IVFR@203494|Verrucomicrobiae	203494|Verrucomicrobiae	C	Isocitrate/isopropylmalate dehydrogenase	-	-	1.1.1.42	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00740	R00267,R00268,R01899	RC00001,RC00084,RC00114,RC00626,RC02801	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
HKD3_k127_4964758_4	1249627.D779_0375	2.122e-91	311.0	COG4261@1|root,COG4261@2|Bacteria,1MVXJ@1224|Proteobacteria,1RNKV@1236|Gammaproteobacteria,1WW87@135613|Chromatiales	135613|Chromatiales	S	Bacterial lipid A biosynthesis acyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Lip_A_acyltrans
HKD3_k127_4964758_6	84531.JMTZ01000016_gene1122	6.137e-33	132.0	COG4706@1|root,COG4706@2|Bacteria,1RIH4@1224|Proteobacteria,1SFAZ@1236|Gammaproteobacteria,1X77B@135614|Xanthomonadales	135614|Xanthomonadales	I	dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_4964758_3	497964.CfE428DRAFT_5920	6.163e-93	311.0	COG1028@1|root,COG1028@2|Bacteria,46SNA@74201|Verrucomicrobia	74201|Verrucomicrobia	IQ	short-chain dehydrogenase reductase SDR	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HKD3_k127_4964758_2	240016.ABIZ01000001_gene1257	1.048e-109	361.0	COG0020@1|root,COG0020@2|Bacteria,46SMY@74201|Verrucomicrobia,2IU5V@203494|Verrucomicrobiae	203494|Verrucomicrobiae	I	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids	-	-	2.5.1.31	ko:K00806	ko00900,ko01110,map00900,map01110	-	R06447	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
HKD3_k127_4964758_0	497964.CfE428DRAFT_1618	1.553e-196	621.0	COG0104@1|root,COG0104@2|Bacteria,46TDF@74201|Verrucomicrobia	74201|Verrucomicrobia	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	-	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
HKD3_k127_4964758_1	1382359.JIAL01000001_gene137	1.865e-114	375.0	COG1968@1|root,COG1968@2|Bacteria,3Y2N3@57723|Acidobacteria,2JI1A@204432|Acidobacteriia	204432|Acidobacteriia	V	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin	uppP	-	3.6.1.27	ko:K06153	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	BacA
HKD3_k127_4964758_5	497964.CfE428DRAFT_6253	4.2e-49	177.0	COG0347@1|root,COG0347@2|Bacteria,46SW8@74201|Verrucomicrobia	74201|Verrucomicrobia	K	nitrogen regulatory protein P-II	-	-	-	ko:K04751,ko:K04752	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	P-II
HKD3_k127_4964758_7	1137281.D778_01482	1.135e-32	140.0	COG3209@1|root,COG5295@1|root,COG3209@2|Bacteria,COG5295@2|Bacteria,4NJTK@976|Bacteroidetes,1HZNB@117743|Flavobacteriia	976|Bacteroidetes	UW	surface antigen	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S74
HKD3_k127_4978929_4	1038869.AXAN01000001_gene3848	2.748e-24	103.0	COG3360@1|root,COG3360@2|Bacteria,1PW6C@1224|Proteobacteria,2VXDE@28216|Betaproteobacteria,1KB0W@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Dodecin	-	-	-	ko:K09165	-	-	-	-	ko00000	-	-	-	Dodecin
HKD3_k127_4978929_3	794903.OPIT5_05540	6.629e-61	217.0	COG1392@1|root,COG1392@2|Bacteria,46SSJ@74201|Verrucomicrobia,3K7IZ@414999|Opitutae	414999|Opitutae	P	Protein of unknown function DUF47	-	-	-	ko:K07220	-	-	-	-	ko00000	-	-	-	PhoU_div
HKD3_k127_4978929_0	794903.OPIT5_05545	1.49e-148	477.0	COG0306@1|root,COG0306@2|Bacteria,46SDP@74201|Verrucomicrobia,3K7HD@414999|Opitutae	414999|Opitutae	P	phosphate transporter	-	-	-	ko:K03306	-	-	-	-	ko00000	2.A.20	-	-	PHO4
HKD3_k127_4978929_2	1266925.JHVX01000001_gene2530	4.869e-80	273.0	COG0783@1|root,COG0783@2|Bacteria,1RAC5@1224|Proteobacteria,2VM4X@28216|Betaproteobacteria	28216|Betaproteobacteria	P	Belongs to the Dps family	dps	-	-	ko:K04047	-	-	-	-	ko00000,ko03036	-	-	-	Ferritin
HKD3_k127_4978929_1	1267534.KB906754_gene3681	4.931e-100	334.0	COG1028@1|root,COG1028@2|Bacteria,3Y42B@57723|Acidobacteria,2JIWX@204432|Acidobacteriia	204432|Acidobacteriia	IQ	PFAM Short-chain dehydrogenase reductase SDR	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HKD3_k127_4978929_5	1403819.BATR01000094_gene2922	2.684e-06	59.0	2DFF9@1|root,2ZRMT@2|Bacteria	2|Bacteria	S	Putative peptidoglycan binding domain	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_1
HKD3_k127_5077044_2	1191523.MROS_1985	1.364e-52	189.0	COG0302@1|root,COG0302@2|Bacteria	2|Bacteria	H	gtp cyclohydrolase	folE	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003933,GO:0003934,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006066,GO:0006725,GO:0006729,GO:0006732,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009108,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019238,GO:0019438,GO:0019751,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034311,GO:0034312,GO:0034641,GO:0035639,GO:0036094,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	3.5.4.16	ko:K01495	ko00790,ko01100,map00790,map01100	M00126,M00841,M00842,M00843	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	-	GTP_cyclohydroI
HKD3_k127_5077044_4	266117.Rxyl_2819	1.987e-41	162.0	COG2345@1|root,COG2345@2|Bacteria	2|Bacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_11,HTH_20,HTH_24,HTH_5,MarR_2
HKD3_k127_5077044_6	880073.Calab_1147	4.501e-19	100.0	COG0720@1|root,COG0720@2|Bacteria,2NR5B@2323|unclassified Bacteria	2|Bacteria	H	6-pyruvoyl tetrahydropterin synthase	-	-	4.1.2.50,4.2.3.12	ko:K01737	ko00790,ko01100,map00790,map01100	M00842,M00843	R04286,R09959	RC01117,RC02846,RC02847	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	PTPS
HKD3_k127_5077044_3	1128421.JAGA01000002_gene937	6.667e-48	187.0	COG0720@1|root,COG0720@2|Bacteria,2NR5B@2323|unclassified Bacteria	2|Bacteria	H	6-pyruvoyl tetrahydropterin synthase	-	-	4.1.2.50,4.2.3.12	ko:K01737	ko00790,ko01100,map00790,map01100	M00842,M00843	R04286,R09959	RC01117,RC02846,RC02847	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	PTPS
HKD3_k127_5077044_5	1521187.JPIM01000030_gene1499	4.181e-40	157.0	COG4221@1|root,COG4221@2|Bacteria,2GBSD@200795|Chloroflexi,375PC@32061|Chloroflexia	32061|Chloroflexia	S	PFAM short-chain dehydrogenase reductase SDR	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HKD3_k127_5077044_0	1223410.KN050846_gene2424	2.036e-83	285.0	COG2964@1|root,COG2964@2|Bacteria	2|Bacteria	S	HTH domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HTH_22,HisKA,PAS_3,PAS_6,PAS_9
HKD3_k127_5077044_1	1183438.GKIL_0413	3.551e-62	237.0	COG2911@1|root,COG5295@1|root,COG2911@2|Bacteria,COG5295@2|Bacteria	2|Bacteria	UW	Hep Hag repeat protein	-	GO:0005575,GO:0005576	-	-	-	-	-	-	-	-	-	-	CBM_3,CHAT,CHU_C,Cohesin,Peptidase_S74
HKD3_k127_5077044_7	449447.MAE_21930	1.401e-05	55.0	2DU7S@1|root,33P96@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_508178_0	497964.CfE428DRAFT_5970	2.001e-229	720.0	COG1217@1|root,COG1217@2|Bacteria,46SHA@74201|Verrucomicrobia	74201|Verrucomicrobia	T	elongation factor Tu domain 2 protein	typA	-	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2
HKD3_k127_508178_2	1463920.JOGB01000009_gene702	1.948e-85	289.0	COG0684@1|root,COG0684@2|Bacteria,2I9PH@201174|Actinobacteria	201174|Actinobacteria	H	Aldolase/RraA	-	-	-	-	-	-	-	-	-	-	-	-	RraA-like
HKD3_k127_508178_5	1031711.RSPO_c00082	4.183e-50	182.0	COG2940@1|root,COG2940@2|Bacteria,1MWFB@1224|Proteobacteria,2VR5U@28216|Betaproteobacteria,1K2B1@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Nuclear protein SET	-	-	-	ko:K07117	-	-	-	-	ko00000	-	-	-	SET
HKD3_k127_508178_4	1210884.HG799467_gene13302	1.239e-59	218.0	COG0583@1|root,COG0583@2|Bacteria,2IXKS@203682|Planctomycetes	203682|Planctomycetes	K	Hydrogen peroxide-inducible genes activator	-	-	-	ko:K04761,ko:K11921	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_1,LysR_substrate
HKD3_k127_508178_3	240016.ABIZ01000001_gene2554	4.975e-70	258.0	COG1075@1|root,COG1075@2|Bacteria	2|Bacteria	KLT	acetyltransferases and hydrolases with the alpha beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6,DUF676,Hydrolase_4,PGAP1
HKD3_k127_508178_1	1202532.FF52_04800	1.346e-186	611.0	COG5164@1|root,COG5164@2|Bacteria,4NFN0@976|Bacteroidetes,1IMWB@117743|Flavobacteriia,2NVM5@237|Flavobacterium	976|Bacteroidetes	K	regulation of DNA-templated transcription, elongation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_508178_6	335543.Sfum_0591	9.402e-50	183.0	COG2930@1|root,COG2930@2|Bacteria,1RAIB@1224|Proteobacteria,42S9D@68525|delta/epsilon subdivisions,2WN8Y@28221|Deltaproteobacteria,2MQJ7@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Las17-binding protein actin regulator	-	-	-	-	-	-	-	-	-	-	-	-	Ysc84
HKD3_k127_508178_7	767434.Fraau_2325	1.433e-49	183.0	COG0406@1|root,COG0406@2|Bacteria,1N8C6@1224|Proteobacteria	1224|Proteobacteria	G	alpha-ribazole phosphatase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_508178_9	981384.AEYW01000028_gene4250	1.432e-10	71.0	2C4HM@1|root,2ZFRV@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_5086492_2	1229780.BN381_350015	1.022e-13	73.0	COG1502@1|root,COG1502@2|Bacteria	2|Bacteria	I	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol	-	-	-	-	-	-	-	-	-	-	-	-	PLDc_2
HKD3_k127_5086492_0	234267.Acid_7851	6.009e-118	405.0	COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,3Y6UN@57723|Acidobacteria	57723|Acidobacteria	K	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_5086492_1	391616.OA238_c21330	1.433e-56	202.0	COG4874@1|root,COG4874@2|Bacteria,1N05R@1224|Proteobacteria,2TVCX@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	protein conserved in bacteria containing a pentein-type domain	-	-	-	-	-	-	-	-	-	-	-	-	Amidinotransf
HKD3_k127_5096930_0	526225.Gobs_4733	1.07e-170	544.0	COG1680@1|root,COG1680@2|Bacteria,2GIX5@201174|Actinobacteria,4ETU2@85013|Frankiales	201174|Actinobacteria	V	Beta-lactamase	lpqK	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
HKD3_k127_5096930_2	41431.PCC8801_2213	2.751e-29	118.0	COG1724@1|root,COG1724@2|Bacteria,1GINS@1117|Cyanobacteria,3KK88@43988|Cyanothece	1117|Cyanobacteria	N	PFAM YcfA family protein	-	-	-	-	-	-	-	-	-	-	-	-	HicA_toxin
HKD3_k127_5096930_3	472759.Nhal_3915	3.571e-26	110.0	COG1598@1|root,COG1598@2|Bacteria,1P4UT@1224|Proteobacteria	1224|Proteobacteria	S	PFAM Uncharacterised protein family UPF0150	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_5096930_1	929556.Solca_0753	4.861e-126	407.0	COG0500@1|root,COG2226@2|Bacteria,4NFRD@976|Bacteroidetes,1IVKT@117747|Sphingobacteriia	976|Bacteroidetes	Q	PFAM Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
HKD3_k127_5096930_4	886293.Sinac_3949	1.466e-10	67.0	2DP3M@1|root,330DW@2|Bacteria,2J0YX@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_5116441_10	994479.GL877878_gene3597	2.837e-24	118.0	COG2246@1|root,COG2246@2|Bacteria,2I4KJ@201174|Actinobacteria,4EDNU@85010|Pseudonocardiales	201174|Actinobacteria	S	polysaccharide biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	GtrA,YfhO
HKD3_k127_5116441_1	497964.CfE428DRAFT_2568	8.702e-137	443.0	COG2220@1|root,COG2220@2|Bacteria,46UIR@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
HKD3_k127_5116441_5	497964.CfE428DRAFT_4289	2.392e-115	379.0	COG0657@1|root,COG0657@2|Bacteria,46U5Z@74201|Verrucomicrobia	74201|Verrucomicrobia	I	Protein of unknown function (DUF1460)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1460
HKD3_k127_5116441_2	864069.MicloDRAFT_00044350	4.017e-126	411.0	COG0715@1|root,COG0715@2|Bacteria,1RHDX@1224|Proteobacteria	1224|Proteobacteria	P	ABC transporter, substrate-binding protein, aliphatic sulfonates family	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	iAF987.Gmet_0996	NMT1_2
HKD3_k127_5116441_3	1403819.BATR01000053_gene1611	3.643e-118	385.0	COG1116@1|root,COG1116@2|Bacteria,46TJD@74201|Verrucomicrobia,2ITUG@203494|Verrucomicrobiae	203494|Verrucomicrobiae	P	ATPases associated with a variety of cellular activities	-	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
HKD3_k127_5116441_4	864069.MicloDRAFT_00044330	4.481e-117	383.0	COG0600@1|root,COG0600@2|Bacteria,1PC26@1224|Proteobacteria,2VFP3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
HKD3_k127_5116441_9	452637.Oter_3355	1.768e-37	158.0	COG3746@1|root,COG3746@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Porin_O_P
HKD3_k127_5116441_13	1396141.BATP01000028_gene2382	3.176e-17	85.0	COG1959@1|root,COG1959@2|Bacteria,46SPI@74201|Verrucomicrobia,2IVTS@203494|Verrucomicrobiae	203494|Verrucomicrobiae	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Rrf2
HKD3_k127_5116441_7	485915.Dret_0286	8.997e-47	180.0	2DG8R@1|root,2ZUYV@2|Bacteria,1RG4Q@1224|Proteobacteria	1224|Proteobacteria	S	Sulfotransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_1
HKD3_k127_5116441_11	1454004.AW11_02570	4.107e-24	104.0	COG4274@1|root,COG4274@2|Bacteria,1MZVV@1224|Proteobacteria,2VUPM@28216|Betaproteobacteria	28216|Betaproteobacteria	S	PFAM GYD family protein	-	-	-	-	-	-	-	-	-	-	-	-	GYD
HKD3_k127_5116441_6	264462.Bd1204	5.356e-65	235.0	COG2453@1|root,COG2453@2|Bacteria,1N2JI@1224|Proteobacteria,43029@68525|delta/epsilon subdivisions,2WVFB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Inositol hexakisphosphate	-	-	3.1.3.48	ko:K01104	-	-	-	-	ko00000,ko01000	-	-	-	PTPlike_phytase
HKD3_k127_5116441_0	478741.JAFS01000002_gene322	1.032e-179	589.0	COG0341@1|root,COG0342@1|root,COG0341@2|Bacteria,COG0342@2|Bacteria,46SA4@74201|Verrucomicrobia,37G1G@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	-	-	ko:K12257	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4	-	-	SecD_SecF,Sec_GG
HKD3_k127_5116441_12	497964.CfE428DRAFT_4288	7.471e-24	105.0	COG1862@1|root,COG1862@2|Bacteria,46T88@74201|Verrucomicrobia	74201|Verrucomicrobia	U	Preprotein translocase subunit	yajC	-	-	ko:K03210	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	YajC
HKD3_k127_5116441_8	395494.Galf_1289	7.477e-39	147.0	COG2227@1|root,COG2227@2|Bacteria,1NPFX@1224|Proteobacteria,2WHPI@28216|Betaproteobacteria	28216|Betaproteobacteria	H	Methionine biosynthesis protein MetW	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23
HKD3_k127_5138230_3	1382230.ASAP_0603	1.117e-13	79.0	COG2067@1|root,COG2067@2|Bacteria,1R6CQ@1224|Proteobacteria,2TTSU@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Putative beta-barrel porin-2, OmpL-like. bbp2	-	-	-	-	-	-	-	-	-	-	-	-	BBP2
HKD3_k127_5138230_2	240016.ABIZ01000001_gene5271	1.73e-74	258.0	COG2156@1|root,COG2156@2|Bacteria,46SYC@74201|Verrucomicrobia,2IVFX@203494|Verrucomicrobiae	203494|Verrucomicrobiae	P	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex	-	-	3.6.3.12	ko:K01548	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	3.A.3.7	-	-	KdpC
HKD3_k127_5138230_0	1403819.BATR01000007_gene220	0.0	1006.0	COG2216@1|root,COG2216@2|Bacteria,46SEM@74201|Verrucomicrobia,2ITIQ@203494|Verrucomicrobiae	203494|Verrucomicrobiae	P	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system	-	-	3.6.3.12	ko:K01547	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	3.A.3.7	-	-	E1-E2_ATPase,Hydrolase
HKD3_k127_5138230_1	240016.ABIZ01000001_gene5273	2.534e-293	909.0	COG2060@1|root,COG2060@2|Bacteria,46S9Y@74201|Verrucomicrobia,2ITVE@203494|Verrucomicrobiae	203494|Verrucomicrobiae	P	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane	-	-	3.6.3.12	ko:K01546	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	3.A.3.7	-	-	KdpA
HKD3_k127_5139102_1	1396141.BATP01000024_gene880	3.706e-31	130.0	29ZIQ@1|root,30MIV@2|Bacteria,46XK8@74201|Verrucomicrobia,2IW4F@203494|Verrucomicrobiae	203494|Verrucomicrobiae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_5139102_2	382464.ABSI01000007_gene4120	1.279e-22	105.0	2F78F@1|root,33ZPQ@2|Bacteria,46VT2@74201|Verrucomicrobia,2IURV@203494|Verrucomicrobiae	203494|Verrucomicrobiae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_5139102_5	289376.THEYE_A0307	2.514e-06	57.0	COG1475@1|root,COG1475@2|Bacteria	2|Bacteria	K	chromosome segregation	-	-	-	-	-	-	-	-	-	-	-	-	ParBc
HKD3_k127_5139102_0	452637.Oter_1936	4.083e-72	258.0	COG0582@1|root,COG0582@2|Bacteria,46TD6@74201|Verrucomicrobia,3K9G2@414999|Opitutae	414999|Opitutae	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
HKD3_k127_5139102_6	1380350.JIAP01000002_gene4747	0.0001919	44.0	COG2827@1|root,COG2827@2|Bacteria,1N04N@1224|Proteobacteria,2UCN4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	excinuclease ABC	-	-	-	-	-	-	-	-	-	-	-	-	GIY-YIG
HKD3_k127_5139102_4	1210884.HG799469_gene14219	1.192e-15	80.0	COG0793@1|root,COG4946@1|root,COG0793@2|Bacteria,COG4946@2|Bacteria,2IX33@203682|Planctomycetes	203682|Planctomycetes	M	Tricorn protease C1 domain	-	-	-	ko:K08676	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PD40,Peptidase_S41,Tricorn_C1,Tricorn_PDZ
HKD3_k127_5206658_1	246197.MXAN_0533	6.069e-55	197.0	COG0451@1|root,COG0451@2|Bacteria,1RBSM@1224|Proteobacteria,42XUG@68525|delta/epsilon subdivisions,2WTSY@28221|Deltaproteobacteria,2YX8Q@29|Myxococcales	28221|Deltaproteobacteria	GM	NAD dependent epimerase/dehydratase family	-	-	1.3.1.45	ko:K05281	ko00943,ko01110,map00943,map01110	-	R06562,R06563,R07747,R07751	RC00805	ko00000,ko00001,ko01000	-	-	-	Epimerase
HKD3_k127_5206658_0	349966.DJ58_3315	1.497e-85	293.0	COG3202@1|root,COG3202@2|Bacteria,1MVP5@1224|Proteobacteria,1RNY6@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	ATP ADP translocase	-	-	-	ko:K03301	-	-	-	-	ko00000	2.A.12	-	-	MFS_1,TLC
HKD3_k127_5217885_3	313606.M23134_08335	1.865e-06	61.0	COG4990@1|root,COG4990@2|Bacteria,4NPUN@976|Bacteroidetes	976|Bacteroidetes	S	G8	-	-	-	-	-	-	-	-	-	-	-	-	G8
HKD3_k127_5217885_1	1538295.JY96_16965	1.439e-49	201.0	COG2304@1|root,COG2911@1|root,COG2931@1|root,COG3210@1|root,COG2304@2|Bacteria,COG2911@2|Bacteria,COG2931@2|Bacteria,COG3210@2|Bacteria,1MU7T@1224|Proteobacteria,2WI67@28216|Betaproteobacteria,1KMDS@119065|unclassified Burkholderiales	28216|Betaproteobacteria	MQU	Domain of unknown function (DUF4347)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4347
HKD3_k127_5217885_2	1123242.JH636435_gene2613	1.586e-49	186.0	COG1595@1|root,COG1595@2|Bacteria,2IZZP@203682|Planctomycetes	203682|Planctomycetes	K	Sigma-70 region 2	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2
HKD3_k127_5217885_0	1210884.HG799462_gene8934	6.566e-80	282.0	COG0515@1|root,COG2319@1|root,COG0515@2|Bacteria,COG2319@2|Bacteria,2IXDF@203682|Planctomycetes	2|Bacteria	KLT	Protein kinase domain	-	-	-	ko:K08738	ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	3.D.4.6	-	-	Cytochrom_C,WD40
HKD3_k127_5246930_6	272134.KB731324_gene1537	0.0007619	44.0	COG2149@1|root,COG2149@2|Bacteria,1G61R@1117|Cyanobacteria,1HB2U@1150|Oscillatoriales	1117|Cyanobacteria	S	membrane	-	-	-	ko:K00389	-	-	-	-	ko00000	-	-	-	DUF202
HKD3_k127_5246930_0	497964.CfE428DRAFT_1453	1.7e-190	617.0	COG0744@1|root,COG0744@2|Bacteria,46U6K@74201|Verrucomicrobia	74201|Verrucomicrobia	M	PFAM glycosyl transferase family 51	-	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase
HKD3_k127_5246930_4	240016.ABIZ01000001_gene5697	2.931e-45	166.0	COG0695@1|root,COG0695@2|Bacteria,46SXS@74201|Verrucomicrobia,2IUDW@203494|Verrucomicrobiae	203494|Verrucomicrobiae	O	Glutaredoxin	-	-	-	-	-	-	-	-	-	-	-	-	Glutaredoxin
HKD3_k127_5246930_5	497964.CfE428DRAFT_2082	1.288e-05	48.0	COG1376@1|root,COG1376@2|Bacteria,46UGX@74201|Verrucomicrobia	74201|Verrucomicrobia	M	L,D-transpeptidase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_1,YkuD
HKD3_k127_5246930_3	1128421.JAGA01000004_gene2686	3.723e-82	276.0	COG2316@1|root,COG2316@2|Bacteria,2NP8E@2323|unclassified Bacteria	2|Bacteria	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	ko:K06951	-	-	-	-	ko00000	-	-	-	HD
HKD3_k127_5246930_1	1121920.AUAU01000001_gene2168	4.168e-93	312.0	COG2519@1|root,COG2519@2|Bacteria,3Y5T2@57723|Acidobacteria	57723|Acidobacteria	J	Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
HKD3_k127_5246930_2	886293.Sinac_2458	2.236e-90	303.0	COG0399@1|root,COG0399@2|Bacteria,2IXZR@203682|Planctomycetes	203682|Planctomycetes	E	DegT/DnrJ/EryC1/StrS aminotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
HKD3_k127_5293325_10	1396141.BATP01000003_gene5228	4.421e-85	291.0	COG0451@1|root,COG0451@2|Bacteria,46XPQ@74201|Verrucomicrobia,2IWC3@203494|Verrucomicrobiae	203494|Verrucomicrobiae	GM	ADP-glyceromanno-heptose 6-epimerase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_5293325_7	1454004.AW11_01567	1.76e-101	343.0	COG0656@1|root,COG0656@2|Bacteria,1MX6S@1224|Proteobacteria,2VNCV@28216|Betaproteobacteria	28216|Betaproteobacteria	S	aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
HKD3_k127_5293325_19	497964.CfE428DRAFT_1046	1.759e-36	144.0	2EJM7@1|root,33DC3@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_5293325_9	886293.Sinac_5242	1.1e-86	295.0	2C3PP@1|root,2Z954@2|Bacteria,2J2AE@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_5293325_4	886293.Sinac_5243	2.698e-132	428.0	COG0115@1|root,COG0115@2|Bacteria,2J2GT@203682|Planctomycetes	203682|Planctomycetes	H	Branched-chain amino acid aminotransferase 4-amino-4-deoxychorismate lyase	-	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
HKD3_k127_5293325_14	497964.CfE428DRAFT_3991	1.11e-58	211.0	2CAZH@1|root,2Z7RU@2|Bacteria,46SY1@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	sdhC	-	-	ko:K00241	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	Sdh_cyt
HKD3_k127_5293325_8	452637.Oter_2747	9.83e-88	308.0	COG2148@1|root,COG2148@2|Bacteria,46V7Y@74201|Verrucomicrobia,3K7HK@414999|Opitutae	414999|Opitutae	M	sugar transferase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_transf
HKD3_k127_5293325_22	452637.Oter_3244	1.506e-23	115.0	COG3307@1|root,COG3307@2|Bacteria,46YCP@74201|Verrucomicrobia,3K9BC@414999|Opitutae	414999|Opitutae	M	O-antigen ligase like membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	Wzy_C
HKD3_k127_5293325_13	1396141.BATP01000020_gene26	2.784e-59	233.0	COG0489@1|root,COG3206@1|root,COG0489@2|Bacteria,COG3206@2|Bacteria,46YXA@74201|Verrucomicrobia,2IVHF@203494|Verrucomicrobiae	203494|Verrucomicrobiae	DM	Chain length determinant protein	-	-	-	-	-	-	-	-	-	-	-	-	Wzz
HKD3_k127_5293325_20	583355.Caka_2436	6.429e-27	120.0	COG1596@1|root,COG1596@2|Bacteria,46YX8@74201|Verrucomicrobia,3K89Y@414999|Opitutae	414999|Opitutae	M	Polysaccharide biosynthesis/export protein	-	-	-	ko:K01991	ko02026,map02026	-	-	-	ko00000,ko00001,ko02000	1.B.18	-	-	Poly_export,SLBB
HKD3_k127_5293325_21	1396141.BATP01000020_gene28	1.833e-26	125.0	COG5338@1|root,COG5338@2|Bacteria	2|Bacteria	P	Protein conserved in bacteria	-	-	-	ko:K20920	ko05111,map05111	-	-	-	ko00000,ko00001,ko02000	1.B.66.3.1,1.B.66.3.2	-	-	BBP2_2
HKD3_k127_5293325_11	880073.Calab_2511	6.847e-83	282.0	COG0602@1|root,COG0602@2|Bacteria,2NPEM@2323|unclassified Bacteria	2|Bacteria	H	Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds	queE	-	1.97.1.4,4.3.99.3	ko:K04068,ko:K10026	ko00790,ko01100,map00790,map01100	-	R04710,R10002	RC02989	ko00000,ko00001,ko01000,ko03016	-	-	iAF987.Gmet_1658	Fer4_14,Radical_SAM
HKD3_k127_5293325_15	1403819.BATR01000102_gene3372	1.077e-57	202.0	COG0720@1|root,COG0720@2|Bacteria,46TAM@74201|Verrucomicrobia,2IVT3@203494|Verrucomicrobiae	203494|Verrucomicrobiae	H	6-pyruvoyl tetrahydropterin synthase	-	-	-	-	-	-	-	-	-	-	-	-	PTPS
HKD3_k127_5293325_2	497964.CfE428DRAFT_0256	1.31e-182	582.0	COG2204@1|root,COG2204@2|Bacteria	2|Bacteria	T	phosphorelay signal transduction system	frgC	-	-	ko:K07714	ko02020,map02020	M00500	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	GAF_2,HTH_8,Pkinase,Response_reg,Sigma54_activat
HKD3_k127_5293325_18	497964.CfE428DRAFT_0255	5.603e-37	151.0	COG5000@1|root,COG5000@2|Bacteria	2|Bacteria	T	phosphorelay sensor kinase activity	-	-	2.7.13.3	ko:K03406,ko:K07675,ko:K13598	ko02020,ko02030,map02020,map02030	M00473,M00498	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	4HB_MCP_1,HAMP,HATPase_c,HisKA,MCPsignal,PAS,PAS_4,PAS_9,dCache_1
HKD3_k127_5293325_1	1297742.A176_06184	5.024e-203	653.0	COG0166@1|root,COG0166@2|Bacteria,1MUFP@1224|Proteobacteria,42MNB@68525|delta/epsilon subdivisions,2WIXQ@28221|Deltaproteobacteria,2YV8R@29|Myxococcales	28221|Deltaproteobacteria	G	Belongs to the GPI family	pgi	-	2.2.1.2,5.3.1.9	ko:K01810,ko:K13810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00004,M00007,M00114	R01827,R02739,R02740,R03321	RC00376,RC00439,RC00563,RC00604	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGI
HKD3_k127_5293325_3	497964.CfE428DRAFT_0415	3.657e-143	465.0	COG2256@1|root,COG2256@2|Bacteria,46S7H@74201|Verrucomicrobia	74201|Verrucomicrobia	L	AAA ATPase central domain protein	-	-	-	ko:K07478	-	-	-	-	ko00000	-	-	-	AAA,AAA_assoc_2,MgsA_C,RuvB_N
HKD3_k127_5293325_23	290315.Clim_2314	2.056e-22	104.0	COG0589@1|root,COG0589@2|Bacteria	2|Bacteria	T	AMP binding	-	-	-	ko:K06149	-	-	-	-	ko00000	-	-	-	Usp
HKD3_k127_5293325_5	1403819.BATR01000087_gene2551	2.758e-104	367.0	COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,46T3W@74201|Verrucomicrobia,2IUFR@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Competence protein	-	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Competence,DUF4131,Lactamase_B
HKD3_k127_5293325_17	497964.CfE428DRAFT_0169	6.795e-43	166.0	COG0220@1|root,COG0220@2|Bacteria,46T5A@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA	trmB	-	2.1.1.33	ko:K03439	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltransf_4
HKD3_k127_5293325_12	1408303.JNJJ01000009_gene2253	9.958e-60	213.0	COG0225@1|root,COG0225@2|Bacteria,1TQ3E@1239|Firmicutes,4HAIV@91061|Bacilli,1ZCC5@1386|Bacillus	91061|Bacilli	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	msrA	-	1.8.4.11,1.8.4.12	ko:K07304,ko:K12267	-	-	-	-	ko00000,ko01000	-	-	-	PMSR,SelR
HKD3_k127_5293325_0	497964.CfE428DRAFT_3990	1.4e-322	996.0	COG1053@1|root,COG1053@2|Bacteria,46S7D@74201|Verrucomicrobia	74201|Verrucomicrobia	C	TIGRFAM succinate dehydrogenase or fumarate reductase, flavoprotein subunit	sdhA	-	1.3.5.1,1.3.5.4	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
HKD3_k127_5293325_16	497964.CfE428DRAFT_2242	1.011e-43	162.0	COG0399@1|root,COG0399@2|Bacteria,46T3Z@74201|Verrucomicrobia	74201|Verrucomicrobia	M	23S rRNA-intervening sequence protein	-	-	-	-	-	-	-	-	-	-	-	-	23S_rRNA_IVP
HKD3_k127_5293325_6	1128421.JAGA01000003_gene2922	2.692e-103	342.0	COG0479@1|root,COG0479@2|Bacteria,2NPY8@2323|unclassified Bacteria	2|Bacteria	C	TIGRFAM succinate dehydrogenase and fumarate reductase iron-sulfur protein	sdhB	-	1.3.5.1,1.3.5.4	ko:K00240,ko:K00245	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020	M00009,M00011,M00149,M00150,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_3,Fer4_7,Fer4_8
HKD3_k127_5318124_1	1458357.BG58_13115	6.312e-23	113.0	COG1073@1|root,COG1073@2|Bacteria,1R9V1@1224|Proteobacteria,2VTA9@28216|Betaproteobacteria,1KB1N@119060|Burkholderiaceae	28216|Betaproteobacteria	S	alpha beta	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_5318124_2	1403819.BATR01000092_gene2748	9.124e-07	61.0	2E3AC@1|root,32Y9V@2|Bacteria	2|Bacteria	S	Putative peptidoglycan binding domain	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_1
HKD3_k127_5318124_0	330214.NIDE2498	5.975e-248	774.0	COG2333@1|root,COG2333@2|Bacteria	2|Bacteria	N	competence protein COMEC	-	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	CW_binding_1,Lactamase_B
HKD3_k127_5467120_30	240016.ABIZ01000001_gene2136	4.112e-20	91.0	COG3837@1|root,COG3837@2|Bacteria,46T0V@74201|Verrucomicrobia,2IU8V@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	AraC-like ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HKD3_k127_5467120_22	1267533.KB906740_gene377	3.971e-54	192.0	COG0662@1|root,COG0662@2|Bacteria	2|Bacteria	G	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HKD3_k127_5467120_26	686340.Metal_4013	1.685e-36	146.0	COG0758@1|root,COG0758@2|Bacteria,1MZGB@1224|Proteobacteria,1S95S@1236|Gammaproteobacteria	1236|Gammaproteobacteria	LU	Putative molybdenum carrier	-	-	-	-	-	-	-	-	-	-	-	-	MoCo_carrier
HKD3_k127_5467120_5	497964.CfE428DRAFT_5137	5.208e-141	460.0	COG4591@1|root,COG4591@2|Bacteria,46SKZ@74201|Verrucomicrobia	74201|Verrucomicrobia	M	MacB-like periplasmic core domain	lolE	-	-	ko:K09808	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.125	-	-	FtsX,MacB_PCD
HKD3_k127_5467120_24	946362.XP_004995136.1	8.552e-49	178.0	COG3651@1|root,2S415@2759|Eukaryota,3AAWZ@33154|Opisthokonta	33154|Opisthokonta	S	Uncharacterized protein conserved in bacteria (DUF2237)	-	-	-	ko:K09966	-	-	-	-	ko00000	-	-	-	DUF2237
HKD3_k127_5467120_19	1403819.BATR01000146_gene4998	4.761e-62	218.0	COG0346@1|root,COG0346@2|Bacteria	2|Bacteria	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase,Glyoxalase_4
HKD3_k127_5467120_29	1173027.Mic7113_2796	6.002e-26	113.0	COG1514@1|root,COG1514@2|Bacteria,1GB04@1117|Cyanobacteria,1HGNX@1150|Oscillatoriales	1117|Cyanobacteria	J	Cyclic phosphodiesterase-like	-	-	-	-	-	-	-	-	-	-	-	-	CPDase
HKD3_k127_5467120_16	497964.CfE428DRAFT_4990	8.443e-67	252.0	COG3071@1|root,COG3071@2|Bacteria,46VFP@74201|Verrucomicrobia	74201|Verrucomicrobia	H	HemY protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_5467120_12	1403819.BATR01000130_gene4633	1.919e-89	312.0	COG0628@1|root,COG0628@2|Bacteria,46VTV@74201|Verrucomicrobia,2ITP8@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
HKD3_k127_5467120_9	497964.CfE428DRAFT_5668	4.685e-119	407.0	COG0457@1|root,COG0457@2|Bacteria,46V4J@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_14,TPR_16,TPR_8
HKD3_k127_5467120_10	661478.OP10G_1948	1.322e-118	408.0	COG0339@1|root,COG0339@2|Bacteria	2|Bacteria	E	metalloendopeptidase activity	prlC	-	3.4.24.15,3.4.24.70	ko:K01392,ko:K01414	ko04614,ko05143,map04614,map05143	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M3
HKD3_k127_5467120_25	1307759.JOMJ01000003_gene1287	1.371e-46	175.0	COG2095@1|root,COG2095@2|Bacteria,1N689@1224|Proteobacteria,42UPI@68525|delta/epsilon subdivisions,2WNQP@28221|Deltaproteobacteria,2MBGT@213115|Desulfovibrionales	28221|Deltaproteobacteria	U	UPF0056 inner membrane protein	-	-	-	ko:K05595	-	-	-	-	ko00000,ko02000	2.A.95.1	-	-	MarC
HKD3_k127_5467120_3	497964.CfE428DRAFT_6681	1.558e-214	674.0	COG0535@1|root,COG0535@2|Bacteria,46V38@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Domain of unknown function (DUF3463)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3463,Radical_SAM
HKD3_k127_5467120_1	497964.CfE428DRAFT_6644	3.097e-285	889.0	COG1657@1|root,COG1657@2|Bacteria,46TK5@74201|Verrucomicrobia	74201|Verrucomicrobia	I	Squalene-hopene cyclase N-terminal domain	sqhC	-	4.2.1.129,5.4.99.17	ko:K06045	ko00909,ko01110,map00909,map01110	-	R07322,R07323	RC01850,RC01851	ko00000,ko00001,ko01000	-	-	-	SQHop_cyclase_C,SQHop_cyclase_N
HKD3_k127_5467120_11	326423.RBAM_023340	9.561e-97	319.0	COG0605@1|root,COG0605@2|Bacteria,1TPXT@1239|Firmicutes,4HA6U@91061|Bacilli,1ZBWK@1386|Bacillus	91061|Bacilli	P	radicals which are normally produced within the cells and which are toxic to biological systems	sodA	GO:0000302,GO:0000303,GO:0000305,GO:0003674,GO:0003824,GO:0004784,GO:0006801,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0010035,GO:0016209,GO:0016491,GO:0016721,GO:0019430,GO:0033554,GO:0034599,GO:0034614,GO:0042221,GO:0044237,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0071450,GO:0071451,GO:0072593,GO:0097237,GO:0098754,GO:0098869,GO:1901700,GO:1901701,GO:1990748	1.15.1.1	ko:K04564	ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016	-	-	-	ko00000,ko00001,ko01000	-	-	-	Sod_Fe_C,Sod_Fe_N
HKD3_k127_5467120_4	497964.CfE428DRAFT_1483	1.429e-199	628.0	COG0436@1|root,COG0436@2|Bacteria,46TMR@74201|Verrucomicrobia	74201|Verrucomicrobia	E	Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate	-	-	2.6.1.83	ko:K10206	ko00300,ko01100,ko01110,ko01130,ko01230,map00300,map01100,map01110,map01130,map01230	M00527	R07613	RC00006,RC01847	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
HKD3_k127_5467120_2	497964.CfE428DRAFT_4772	1.11e-220	694.0	COG3011@1|root,COG3011@2|Bacteria,46U84@74201|Verrucomicrobia	2|Bacteria	S	Lipase maturation factor	LMF	-	-	-	-	-	-	-	-	-	-	-	LMF1
HKD3_k127_5467120_13	497964.CfE428DRAFT_6171	8.362e-87	309.0	COG1073@1|root,COG1073@2|Bacteria,46VGX@74201|Verrucomicrobia	74201|Verrucomicrobia	S	alpha beta	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_5467120_21	497964.CfE428DRAFT_6170	7.68e-56	217.0	COG0204@1|root,COG0204@2|Bacteria,46VPE@74201|Verrucomicrobia	74201|Verrucomicrobia	I	Phosphate acyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Acyltransferase
HKD3_k127_5467120_0	1121472.AQWN01000011_gene1225	1.593e-300	951.0	COG0506@1|root,COG1012@1|root,COG0506@2|Bacteria,COG1012@2|Bacteria,1TP4S@1239|Firmicutes,247W7@186801|Clostridia,26131@186807|Peptococcaceae	186801|Clostridia	C	Belongs to the aldehyde dehydrogenase family	rocA	-	1.2.1.88	ko:K00294	ko00250,ko00330,ko01100,map00250,map00330,map01100	-	R00245,R00707,R00708,R04444,R04445,R05051	RC00080,RC00216,RC00242,RC00255	ko00000,ko00001,ko01000	-	-	-	Aldedh,Pro_dh
HKD3_k127_5467120_34	497964.CfE428DRAFT_0891	8.063e-11	70.0	2DBSP@1|root,2ZAT9@2|Bacteria,46TYZ@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_5467120_7	517418.Ctha_0233	1.904e-134	456.0	COG4232@1|root,COG4233@1|root,COG4232@2|Bacteria,COG4233@2|Bacteria,1FDRS@1090|Chlorobi	1090|Chlorobi	C	Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps	dsbD	-	1.8.1.8	ko:K04084	-	-	-	-	ko00000,ko01000,ko03110	5.A.1.1	-	-	DsbC,DsbD,Thioredoxin_7
HKD3_k127_5467120_17	498211.CJA_3158	3.118e-65	229.0	COG1225@1|root,COG1225@2|Bacteria,1RD2X@1224|Proteobacteria,1S3TJ@1236|Gammaproteobacteria,1FHI6@10|Cellvibrio	1236|Gammaproteobacteria	O	Redoxin	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
HKD3_k127_5467120_18	497964.CfE428DRAFT_4825	6.72e-63	226.0	COG0300@1|root,COG0300@2|Bacteria,46V6A@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Enoyl-(Acyl carrier protein) reductase	dltE	-	-	ko:K07124	-	-	-	-	ko00000	-	-	-	adh_short
HKD3_k127_5467120_15	497964.CfE428DRAFT_5456	2.099e-68	241.0	COG1187@1|root,COG1187@2|Bacteria,46SWQ@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Belongs to the pseudouridine synthase RsuA family	rsuA	-	5.4.99.22	ko:K06178	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
HKD3_k127_5467120_33	497964.CfE428DRAFT_3212	5.309e-17	83.0	2DSQH@1|root,33H1Z@2|Bacteria,46TBQ@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_5467120_20	1156937.MFUM_810025	4.762e-58	224.0	COG1807@1|root,COG1807@2|Bacteria,46SXK@74201|Verrucomicrobia,37G5C@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HKD3_k127_5467120_23	497964.CfE428DRAFT_5348	9.066e-53	190.0	COG0824@1|root,COG0824@2|Bacteria,46T37@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Thioesterase-like superfamily	fcbC	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT,4HBT_2
HKD3_k127_5467120_27	452637.Oter_3771	1.541e-32	138.0	COG0400@1|root,COG0400@2|Bacteria	2|Bacteria	S	palmitoyl-(protein) hydrolase activity	-	-	-	ko:K06999	-	-	-	-	ko00000	-	-	-	PE-PPE,VKG_Carbox
HKD3_k127_5467120_28	1121324.CLIT_11c02670	2.545e-26	113.0	2E74N@1|root,331P2@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_5467120_8	497964.CfE428DRAFT_5303	2.226e-121	401.0	COG3481@1|root,COG3481@2|Bacteria,46SYB@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	ko:K03698	-	-	-	-	ko00000,ko01000,ko03019	-	-	-	HD
HKD3_k127_5467120_6	1128421.JAGA01000003_gene2811	1.651e-137	449.0	COG0498@1|root,COG0498@2|Bacteria,2NP42@2323|unclassified Bacteria	2|Bacteria	E	Threonine synthase	MA20_41710	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HKD3_k127_5467120_32	469383.Cwoe_1697	5.717e-19	91.0	COG5607@1|root,COG5607@2|Bacteria,2HQYQ@201174|Actinobacteria,4CSRG@84995|Rubrobacteria	84995|Rubrobacteria	S	CHAD	-	-	-	-	-	-	-	-	-	-	-	-	CHAD
HKD3_k127_5477627_2	861299.J421_2025	4.299e-24	104.0	COG2021@1|root,COG2021@2|Bacteria,1ZT4X@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	alpha/beta hydrolase fold	-	-	2.3.1.31	ko:K00641	ko00270,ko01100,ko01130,map00270,map01100,map01130	-	R01776	RC00004,RC00041	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1
HKD3_k127_5477627_0	316058.RPB_2776	4.667e-89	300.0	COG2520@1|root,COG2520@2|Bacteria,1N43N@1224|Proteobacteria,2UDB4@28211|Alphaproteobacteria,3JXB9@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	J	Methyltransferase fkbm family	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_5477627_3	240016.ABIZ01000001_gene1203	3.584e-22	100.0	COG1943@1|root,COG1943@2|Bacteria,46VNW@74201|Verrucomicrobia	74201|Verrucomicrobia	L	Transposase IS200 like	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
HKD3_k127_5477627_1	1183438.GKIL_3588	1.41e-85	287.0	COG2234@1|root,COG2234@2|Bacteria	2|Bacteria	DZ	aminopeptidase activity	pgcp	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_M28
HKD3_k127_5486488_1	497964.CfE428DRAFT_3933	2.859e-83	281.0	COG0745@1|root,COG0745@2|Bacteria,46SS3@74201|Verrucomicrobia	74201|Verrucomicrobia	T	Two component transcriptional regulator, winged helix family	-	-	-	ko:K07657	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
HKD3_k127_5486488_0	497964.CfE428DRAFT_3934	8.544e-94	322.0	COG5002@1|root,COG5002@2|Bacteria,46SSA@74201|Verrucomicrobia	74201|Verrucomicrobia	T	PFAM ATP-binding region ATPase domain protein	-	-	2.7.13.3	ko:K07636	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS,PAS_4,PAS_9
HKD3_k127_5486488_2	443143.GM18_1307	2.551e-11	68.0	COG0226@1|root,COG0226@2|Bacteria,1MUAZ@1224|Proteobacteria,42NM3@68525|delta/epsilon subdivisions,2WMH9@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	Part of the ABC transporter complex PstSACB involved in phosphate import	pstS	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
HKD3_k127_5492412_0	1278073.MYSTI_00935	5.019e-138	450.0	COG3844@1|root,COG3844@2|Bacteria,1MUKN@1224|Proteobacteria,42YAM@68525|delta/epsilon subdivisions,2WUNV@28221|Deltaproteobacteria,2YV4X@29|Myxococcales	28221|Deltaproteobacteria	F	Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively	kynU	-	3.7.1.3	ko:K01556	ko00380,ko01100,map00380,map01100	M00038	R00987,R02668,R03936	RC00284,RC00415	ko00000,ko00001,ko00002,ko01000	-	-	-	Aminotran_5
HKD3_k127_5492412_5	1380355.JNIJ01000029_gene3089	3.151e-40	154.0	COG0346@1|root,COG0346@2|Bacteria,1RFHY@1224|Proteobacteria,2U8QB@28211|Alphaproteobacteria,3JYWP@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase,Glyoxalase_4
HKD3_k127_5492412_3	1144275.COCOR_00870	8.729e-57	200.0	COG0251@1|root,COG0251@2|Bacteria,1MYEM@1224|Proteobacteria	1224|Proteobacteria	J	Translation initiation inhibitor, yjgF family	-	-	3.5.99.5	ko:K15067	ko00380,map00380	-	R03887	RC01015	ko00000,ko00001,ko01000	-	-	-	Ribonuc_L-PSP
HKD3_k127_5492412_4	296591.Bpro_3363	2.447e-42	160.0	COG5580@1|root,COG5580@2|Bacteria,1NMBI@1224|Proteobacteria,2W5GZ@28216|Betaproteobacteria	28216|Betaproteobacteria	O	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
HKD3_k127_5492412_2	1267533.KB906736_gene966	6.548e-106	351.0	COG0412@1|root,COG0412@2|Bacteria,3Y8GG@57723|Acidobacteria	57723|Acidobacteria	Q	BAAT / Acyl-CoA thioester hydrolase C terminal	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_5492412_6	1047013.AQSP01000131_gene1797	3.044e-29	133.0	COG0823@1|root,COG0823@2|Bacteria,2NPHZ@2323|unclassified Bacteria	2|Bacteria	U	WD40-like Beta Propeller Repeat	-	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40
HKD3_k127_5492412_1	1237149.C900_03217	4.939e-111	364.0	COG1012@1|root,COG1012@2|Bacteria,4NEB7@976|Bacteroidetes,47JKD@768503|Cytophagia	976|Bacteroidetes	C	Belongs to the aldehyde dehydrogenase family	-	-	1.2.1.3,1.2.1.32,1.2.1.85	ko:K00128,ko:K10217	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00362,ko00380,ko00410,ko00561,ko00620,ko00622,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00362,map00380,map00410,map00561,map00620,map00622,map00625,map00903,map00981,map01100,map01110,map01120,map01130,map01220	M00038,M00135,M00569	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02762,R02940,R02957,R03283,R03869,R03889,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R05353,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00254,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
HKD3_k127_5508948_11	313606.M23134_00438	1.072e-95	321.0	COG1012@1|root,COG1012@2|Bacteria,4NEB7@976|Bacteroidetes,47JKD@768503|Cytophagia	976|Bacteroidetes	C	Belongs to the aldehyde dehydrogenase family	-	-	1.2.1.3,1.2.1.32,1.2.1.85	ko:K00128,ko:K10217	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00362,ko00380,ko00410,ko00561,ko00620,ko00622,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00362,map00380,map00410,map00561,map00620,map00622,map00625,map00903,map00981,map01100,map01110,map01120,map01130,map01220	M00038,M00135,M00569	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02762,R02940,R02957,R03283,R03869,R03889,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R05353,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00254,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
HKD3_k127_5508948_3	1267534.KB906759_gene1889	3.049e-223	707.0	COG0671@1|root,COG0671@2|Bacteria,3Y6DG@57723|Acidobacteria	57723|Acidobacteria	I	phosphoesterase, PA-phosphatase related	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_5508948_26	1183438.GKIL_0413	3.528e-57	216.0	COG2911@1|root,COG5295@1|root,COG2911@2|Bacteria,COG5295@2|Bacteria	2|Bacteria	UW	Hep Hag repeat protein	-	GO:0005575,GO:0005576	-	-	-	-	-	-	-	-	-	-	CBM_3,CHAT,CHU_C,Cohesin,Peptidase_S74
HKD3_k127_5508948_5	1267533.KB906740_gene247	2.588e-165	529.0	COG1234@1|root,COG1234@2|Bacteria,3Y7KR@57723|Acidobacteria	57723|Acidobacteria	S	Metallo-beta-lactamase superfamily	-	-	3.1.26.11	ko:K00784	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Lactamase_B_2
HKD3_k127_5508948_14	1168065.DOK_05770	3.457e-79	278.0	COG0303@1|root,COG0303@2|Bacteria,1MVD5@1224|Proteobacteria,1RMQU@1236|Gammaproteobacteria,1J4IQ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	H	COG0303 Molybdopterin biosynthesis enzyme	moeA	-	2.10.1.1	ko:K03750	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N
HKD3_k127_5508948_30	497964.CfE428DRAFT_5937	1.301e-44	169.0	COG1846@1|root,COG1846@2|Bacteria,46VKR@74201|Verrucomicrobia	74201|Verrucomicrobia	K	Winged helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	MarR
HKD3_k127_5508948_25	497964.CfE428DRAFT_5939	1.069e-57	221.0	COG1538@1|root,COG1538@2|Bacteria,46T0P@74201|Verrucomicrobia	74201|Verrucomicrobia	MU	PFAM outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
HKD3_k127_5508948_18	497964.CfE428DRAFT_5940	9.951e-71	246.0	COG1496@1|root,COG1496@2|Bacteria,46STZ@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Multi-copper polyphenol oxidoreductase laccase	-	-	-	ko:K05810	-	-	-	-	ko00000,ko01000	-	-	-	Cu-oxidase_4
HKD3_k127_5508948_24	497964.CfE428DRAFT_0350	6.181e-58	205.0	COG1666@1|root,COG1666@2|Bacteria,46VRB@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Protein of unknown function (DUF520)	-	-	-	-	-	-	-	-	-	-	-	-	DUF520
HKD3_k127_5508948_2	497964.CfE428DRAFT_4840	3.06e-235	739.0	COG0606@1|root,COG0606@2|Bacteria,46SAK@74201|Verrucomicrobia	74201|Verrucomicrobia	O	PFAM magnesium chelatase ChlI subunit	-	-	-	ko:K07391	-	-	-	-	ko00000	-	-	-	ChlI,Mg_chelatase,Mg_chelatase_C
HKD3_k127_5508948_6	497964.CfE428DRAFT_4839	1.044e-155	494.0	COG0568@1|root,COG0568@2|Bacteria,46SJ8@74201|Verrucomicrobia	74201|Verrucomicrobia	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	-	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
HKD3_k127_5508948_35	448385.sce4540	0.0001228	47.0	COG0469@1|root,COG0469@2|Bacteria,1MU21@1224|Proteobacteria,42N30@68525|delta/epsilon subdivisions,2WJSW@28221|Deltaproteobacteria,2YUEU@29|Myxococcales	28221|Deltaproteobacteria	G	Belongs to the pyruvate kinase family	pyk	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PK,PK_C
HKD3_k127_5508948_7	497964.CfE428DRAFT_3476	2.44e-132	436.0	COG0457@1|root,COG0457@2|Bacteria,46TQ7@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_8
HKD3_k127_5508948_9	926550.CLDAP_33840	2.792e-116	384.0	COG1313@1|root,COG1313@2|Bacteria,2G65I@200795|Chloroflexi	200795|Chloroflexi	C	Radical SAM domain protein	-	-	1.97.1.4	ko:K04070	-	-	-	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
HKD3_k127_5508948_1	247490.KSU1_D0975	8.087e-247	788.0	COG0249@1|root,COG0249@2|Bacteria,2IXGV@203682|Planctomycetes	203682|Planctomycetes	L	that it carries out the mismatch recognition step. This protein has a weak ATPase activity	mutS	GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
HKD3_k127_5508948_33	497964.CfE428DRAFT_0345	2.731e-24	102.0	COG0828@1|root,COG0828@2|Bacteria,46WUR@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Ribosomal protein S21	-	-	-	-	-	-	-	-	-	-	-	-	Ribosomal_S21
HKD3_k127_5508948_4	497964.CfE428DRAFT_0339	3.272e-209	661.0	COG0007@1|root,COG1587@1|root,COG0007@2|Bacteria,COG1587@2|Bacteria,46S9P@74201|Verrucomicrobia	74201|Verrucomicrobia	H	Belongs to the precorrin methyltransferase family	cysG	-	2.1.1.107,4.2.1.75	ko:K02303,ko:K13542	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R03165,R03194	RC00003,RC00871,RC01861	ko00000,ko00001,ko00002,ko01000	-	-	-	HEM4,TP_methylase
HKD3_k127_5508948_21	497964.CfE428DRAFT_4316	1.227e-62	226.0	COG0181@1|root,COG0181@2|Bacteria,46SWD@74201|Verrucomicrobia	74201|Verrucomicrobia	H	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps	hemC	-	2.5.1.61	ko:K01749	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00084	RC02317	ko00000,ko00001,ko00002,ko01000	-	-	-	Porphobil_deam,Porphobil_deamC
HKD3_k127_5508948_13	497964.CfE428DRAFT_4315	1.773e-82	287.0	COG0373@1|root,COG0373@2|Bacteria,46SMQ@74201|Verrucomicrobia	74201|Verrucomicrobia	H	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)	hemA	-	1.2.1.70	ko:K02492	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R04109	RC00055,RC00149	ko00000,ko00001,ko00002,ko01000	-	-	-	GlutR_N,Shikimate_DH
HKD3_k127_5508948_17	497964.CfE428DRAFT_4314	6.867e-71	248.0	COG4137@1|root,COG4137@2|Bacteria,46T0T@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Cytochrome C assembly protein	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C_asm
HKD3_k127_5508948_20	497964.CfE428DRAFT_3538	1.686e-63	224.0	COG0503@1|root,COG0503@2|Bacteria,46SV8@74201|Verrucomicrobia	74201|Verrucomicrobia	F	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis	apt	-	2.4.2.7	ko:K00759	ko00230,ko01100,map00230,map01100	-	R00190,R01229,R04378	RC00063	ko00000,ko00001,ko01000,ko04147	-	-	-	Pribosyltran
HKD3_k127_5508948_0	497964.CfE428DRAFT_0257	2.904e-307	969.0	COG2844@1|root,COG2844@2|Bacteria,46SI6@74201|Verrucomicrobia	74201|Verrucomicrobia	O	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen	glnD	-	2.7.7.59	ko:K00990	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	-	-	-	DUF294,GlnD_UR_UTase,GlnE,HD,NTP_transf_2
HKD3_k127_5508948_12	497964.CfE428DRAFT_4748	2.557e-93	315.0	COG1208@1|root,COG1208@2|Bacteria,46V3X@74201|Verrucomicrobia	74201|Verrucomicrobia	JM	Nucleotidyl transferase	-	-	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
HKD3_k127_5508948_34	330214.NIDE3376	2.363e-22	101.0	2ETMV@1|root,33M5M@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF5069)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5069
HKD3_k127_5508948_23	497964.CfE428DRAFT_4380	3.013e-60	218.0	COG1664@1|root,COG1664@2|Bacteria,46WDW@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Polymer-forming cytoskeletal	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
HKD3_k127_5508948_28	497964.CfE428DRAFT_4379	4.324e-48	179.0	COG1664@1|root,COG1664@2|Bacteria,46VS6@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Polymer-forming cytoskeletal	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
HKD3_k127_5508948_31	760192.Halhy_5102	2.917e-44	173.0	COG3011@1|root,COG3011@2|Bacteria,4NP4T@976|Bacteroidetes,1IXPR@117747|Sphingobacteriia	976|Bacteroidetes	S	HTTM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	VKG_Carbox
HKD3_k127_5508948_36	760192.Halhy_5103	0.000666	50.0	2ER00@1|root,33IJJ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_5508948_15	1210884.HG799462_gene8934	7.44e-74	280.0	COG0515@1|root,COG2319@1|root,COG0515@2|Bacteria,COG2319@2|Bacteria,2IXDF@203682|Planctomycetes	2|Bacteria	KLT	Protein kinase domain	-	-	-	ko:K08738	ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	3.D.4.6	-	-	Cytochrom_C,WD40
HKD3_k127_5508948_29	1396141.BATP01000019_gene1732	1.601e-47	181.0	COG1595@1|root,COG1595@2|Bacteria,46V3P@74201|Verrucomicrobia	74201|Verrucomicrobia	K	DNA-templated transcription, initiation	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2
HKD3_k127_5508948_16	768671.ThimaDRAFT_0847	6.009e-71	263.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,1SA31@1236|Gammaproteobacteria	1224|Proteobacteria	T	SMART ATP-binding region, ATPase-like	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3
HKD3_k127_5508948_27	497964.CfE428DRAFT_1737	5.675e-50	187.0	COG2197@1|root,COG2197@2|Bacteria,46V5Z@74201|Verrucomicrobia	74201|Verrucomicrobia	T	Two component transcriptional regulator, LuxR family	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HKD3_k127_5508948_32	1190606.AJYG01000102_gene1226	9.351e-44	165.0	COG3247@1|root,COG3247@2|Bacteria,1RH69@1224|Proteobacteria,1SAIB@1236|Gammaproteobacteria,1Y0A9@135623|Vibrionales	135623|Vibrionales	S	Short repeat of unknown function (DUF308)	-	-	-	-	-	-	-	-	-	-	-	-	DUF308
HKD3_k127_5508948_22	497964.CfE428DRAFT_4884	1.339e-62	226.0	29JAD@1|root,3067W@2|Bacteria,46VPD@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_5508948_10	497964.CfE428DRAFT_0870	4.817e-96	321.0	COG0253@1|root,COG0253@2|Bacteria,46SKV@74201|Verrucomicrobia	74201|Verrucomicrobia	E	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan	dapF	-	5.1.1.7	ko:K01778	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00527	R02735	RC00302	ko00000,ko00001,ko00002,ko01000	-	-	-	DAP_epimerase
HKD3_k127_5508948_19	1396141.BATP01000007_gene5537	1.923e-69	240.0	COG0329@1|root,COG0329@2|Bacteria,46SDY@74201|Verrucomicrobia,2ITUK@203494|Verrucomicrobiae	203494|Verrucomicrobiae	EM	Dihydrodipicolinate synthetase family	dapA	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
HKD3_k127_561286_1	204669.Acid345_1883	1.383e-55	200.0	COG2876@1|root,COG2876@2|Bacteria,3Y32G@57723|Acidobacteria,2JIXH@204432|Acidobacteriia	204432|Acidobacteriia	E	NeuB family	-	-	2.5.1.54	ko:K03856	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_1
HKD3_k127_561286_0	1121920.AUAU01000007_gene416	1.928e-259	812.0	COG1164@1|root,COG1164@2|Bacteria,3Y2SB@57723|Acidobacteria	57723|Acidobacteria	E	Angiotensin-converting enzyme	-	-	3.4.15.1	ko:K01283	ko04614,ko04924,ko05142,ko05410,map04614,map04924,map05142,map05410	-	-	-	ko00000,ko00001,ko01000,ko01002,ko04090,ko04147	-	-	-	Peptidase_M2
HKD3_k127_563700_7	1183438.GKIL_3722	5.498e-222	698.0	COG1505@1|root,COG1505@2|Bacteria,1G1B7@1117|Cyanobacteria	1117|Cyanobacteria	E	PFAM Prolyl oligopeptidase, N-terminal beta-propeller domain	-	-	3.4.21.26	ko:K01322	ko04614,map04614	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S9,Peptidase_S9_N
HKD3_k127_563700_55	1396141.BATP01000023_gene513	1.952e-28	130.0	2AEXX@1|root,314VS@2|Bacteria,46YXW@74201|Verrucomicrobia,2IUHX@203494|Verrucomicrobiae	203494|Verrucomicrobiae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_563700_11	497964.CfE428DRAFT_6711	3.559e-157	507.0	COG5000@1|root,COG5000@2|Bacteria,46S9Q@74201|Verrucomicrobia	74201|Verrucomicrobia	T	PFAM ATP-binding region ATPase domain protein	ntrB	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_4,PAS_8
HKD3_k127_563700_53	93220.LV28_17325	3.8e-31	135.0	COG0628@1|root,COG0628@2|Bacteria,1MW34@1224|Proteobacteria,2VIKI@28216|Betaproteobacteria,1K0I9@119060|Burkholderiaceae	28216|Betaproteobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
HKD3_k127_563700_1	497964.CfE428DRAFT_3556	0.0	1015.0	COG1185@1|root,COG1185@2|Bacteria,46SBP@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	-	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
HKD3_k127_563700_56	497964.CfE428DRAFT_3558	7.325e-26	110.0	COG0184@1|root,COG0184@2|Bacteria,46T87@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome	rpsO	-	-	ko:K02956	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S15
HKD3_k127_563700_44	1122185.N792_12190	6.473e-48	180.0	COG1215@1|root,COG1215@2|Bacteria,1QU2M@1224|Proteobacteria,1SCHV@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HKD3_k127_563700_43	1278073.MYSTI_01900	1.723e-48	178.0	COG1670@1|root,COG1670@2|Bacteria,1N4JG@1224|Proteobacteria	1224|Proteobacteria	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
HKD3_k127_563700_37	497964.CfE428DRAFT_5171	9.786e-60	210.0	COG0346@1|root,COG0346@2|Bacteria	2|Bacteria	E	lactoylglutathione lyase activity	fosB2	-	4.4.1.5	ko:K01759	ko00620,map00620	-	R02530	RC00004,RC00740	ko00000,ko00001,ko01000	-	-	-	Glyoxalase
HKD3_k127_563700_14	234267.Acid_5939	2.337e-145	476.0	COG1807@1|root,COG1807@2|Bacteria,3Y383@57723|Acidobacteria	57723|Acidobacteria	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HKD3_k127_563700_10	452637.Oter_2162	2.415e-157	503.0	COG1181@1|root,COG1181@2|Bacteria	2|Bacteria	F	Belongs to the D-alanine--D-alanine ligase family	ddlB1	-	6.3.2.4,6.3.5.5	ko:K01921,ko:K01955	ko00240,ko00250,ko00473,ko00550,ko01100,ko01502,map00240,map00250,map00473,map00550,map01100,map01502	M00051	R00256,R00575,R01150,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC00064,RC00141,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000,ko01011	-	-	-	Dala_Dala_lig_C
HKD3_k127_563700_13	452637.Oter_2161	3.521e-154	497.0	COG4307@1|root,COG4307@2|Bacteria	2|Bacteria	T	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_Mx,zinc-ribbon_6
HKD3_k127_563700_15	1403819.BATR01000162_gene5395	1.111e-144	477.0	COG0457@1|root,COG0457@2|Bacteria,46W9Q@74201|Verrucomicrobia,2IVDS@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_563700_58	497964.CfE428DRAFT_1875	6.175e-23	114.0	COG0515@1|root,COG1262@1|root,COG0515@2|Bacteria,COG1262@2|Bacteria	2|Bacteria	T	PFAM Formylglycine-generating sulfatase enzyme	-	-	-	-	-	-	-	-	-	-	-	-	DUF4062,FGE-sulfatase,Metallophos,NACHT,PEGA,Pkinase
HKD3_k127_563700_18	382464.ABSI01000005_gene1099	1.657e-115	377.0	COG0396@1|root,COG0396@2|Bacteria,46SGE@74201|Verrucomicrobia,2ITY7@203494|Verrucomicrobiae	203494|Verrucomicrobiae	O	ATPases associated with a variety of cellular activities	-	-	-	ko:K09013	-	-	-	-	ko00000,ko02000	-	-	-	ABC_tran
HKD3_k127_563700_2	497964.CfE428DRAFT_3018	3.077e-268	829.0	COG0719@1|root,COG0719@2|Bacteria,46SGN@74201|Verrucomicrobia	74201|Verrucomicrobia	O	TIGRFAM FeS assembly protein SufB	-	-	-	ko:K09014	-	-	-	-	ko00000	-	-	-	UPF0051
HKD3_k127_563700_12	497964.CfE428DRAFT_3019	3.075e-155	501.0	COG0719@1|root,COG0719@2|Bacteria,46S8S@74201|Verrucomicrobia	74201|Verrucomicrobia	O	FeS assembly protein SufD	-	-	-	ko:K09015	-	-	-	-	ko00000	-	-	-	UPF0051
HKD3_k127_563700_47	497964.CfE428DRAFT_5287	1.378e-39	151.0	COG0848@1|root,COG0848@2|Bacteria,46T4F@74201|Verrucomicrobia	74201|Verrucomicrobia	U	PFAM Biopolymer transport protein ExbD TolR	-	-	-	ko:K03559	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	ExbD
HKD3_k127_563700_22	497964.CfE428DRAFT_5288	8.221e-102	337.0	COG0811@1|root,COG0811@2|Bacteria,46V4I@74201|Verrucomicrobia	74201|Verrucomicrobia	U	MotA/TolQ/ExbB proton channel family	-	-	-	ko:K03562	ko01120,map01120	-	-	-	ko00000,ko02000	1.A.30.2.2	-	-	MotA_ExbB
HKD3_k127_563700_21	240016.ABIZ01000001_gene4519	6.015e-103	346.0	COG0682@1|root,COG0682@2|Bacteria,46SSY@74201|Verrucomicrobia,2IU4I@203494|Verrucomicrobiae	203494|Verrucomicrobiae	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	lgt	-	-	ko:K13292	-	-	-	-	ko00000,ko01000	-	-	-	LGT
HKD3_k127_563700_0	497964.CfE428DRAFT_4764	0.0	2426.0	COG0178@1|root,COG0178@2|Bacteria,46SAF@74201|Verrucomicrobia	74201|Verrucomicrobia	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	-	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
HKD3_k127_563700_3	497964.CfE428DRAFT_6083	2.977e-264	825.0	COG1274@1|root,COG1274@2|Bacteria,46UB8@74201|Verrucomicrobia	74201|Verrucomicrobia	H	Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle	pckG	-	4.1.1.32	ko:K01596	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko03320,ko04068,ko04151,ko04152,ko04910,ko04920,ko04922,ko04931,ko04964,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map03320,map04068,map04151,map04152,map04910,map04920,map04922,map04931,map04964	M00003	R00431,R00726	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPCK_C,PEPCK_N
HKD3_k127_563700_49	478741.JAFS01000002_gene123	1.856e-37	152.0	COG0705@1|root,COG0705@2|Bacteria,46T69@74201|Verrucomicrobia,37GH0@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	S	Rhomboid family	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
HKD3_k127_563700_36	926566.Terro_1380	1.931e-60	214.0	COG0279@1|root,COG0279@2|Bacteria,3Y4UX@57723|Acidobacteria,2JJJ4@204432|Acidobacteriia	204432|Acidobacteriia	G	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate	gmhA	-	5.3.1.28	ko:K03271	ko00540,ko01100,map00540,map01100	M00064	R05645,R09768,R09769	RC00434	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	SIS_2
HKD3_k127_563700_33	497964.CfE428DRAFT_3416	4.506e-68	237.0	COG3963@1|root,COG3963@2|Bacteria	2|Bacteria	I	phosphatidate phosphatase activity	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25,RrnaAD
HKD3_k127_563700_8	240016.ABIZ01000001_gene3871	2.152e-199	634.0	COG0114@1|root,COG0114@2|Bacteria,46SFC@74201|Verrucomicrobia,2IVK5@203494|Verrucomicrobiae	203494|Verrucomicrobiae	C	Fumarase C C-terminus	-	-	-	-	-	-	-	-	-	-	-	-	FumaraseC_C,Lyase_1
HKD3_k127_563700_50	713586.KB900536_gene1302	1.001e-34	136.0	COG0346@1|root,COG0346@2|Bacteria,1REFQ@1224|Proteobacteria,1S3NT@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_563700_25	497964.CfE428DRAFT_4823	3.033e-98	338.0	2EYYY@1|root,33S5Q@2|Bacteria,46UHA@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Fungal chitosanase of glycosyl hydrolase group 75	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_75
HKD3_k127_563700_62	1173024.KI912148_gene4068	7.199e-10	64.0	COG5548@1|root,COG5548@2|Bacteria,1G997@1117|Cyanobacteria,1JIY6@1189|Stigonemataceae	1117|Cyanobacteria	S	Transmembrane proteins 14C	-	-	-	-	-	-	-	-	-	-	-	-	Tmemb_14
HKD3_k127_563700_20	344747.PM8797T_00277	2.356e-104	352.0	COG1915@1|root,COG1915@2|Bacteria,2IWVZ@203682|Planctomycetes	203682|Planctomycetes	S	PFAM LOR SDH bifunctional	-	-	-	-	-	-	-	-	-	-	-	-	Saccharop_dh_N
HKD3_k127_563700_27	575540.Isop_3073	4.67e-91	306.0	COG1834@1|root,COG1834@2|Bacteria,2IXSX@203682|Planctomycetes	203682|Planctomycetes	E	Amidinotransferase	-	-	-	-	-	-	-	-	-	-	-	-	Amidinotransf
HKD3_k127_563700_6	497964.CfE428DRAFT_3156	2.093e-227	721.0	COG1387@1|root,COG1387@2|Bacteria,46TH0@74201|Verrucomicrobia	74201|Verrucomicrobia	L	DNA polymerase X family	-	-	-	ko:K02347	-	-	-	-	ko00000,ko03400	-	-	-	DNA_pol_B_thumb,HHH_5,HHH_8,PHP
HKD3_k127_563700_54	313624.NSP_13770	1.535e-28	133.0	COG1404@1|root,COG2755@1|root,COG2834@1|root,COG1404@2|Bacteria,COG2755@2|Bacteria,COG2834@2|Bacteria,1GIN1@1117|Cyanobacteria,1HNE9@1161|Nostocales	1117|Cyanobacteria	MOQ	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	-	-	-	-	-	-	-	-	-	Calx-beta,PPC,Peptidase_S8,SdrD_B
HKD3_k127_563700_52	234267.Acid_7072	4.68e-34	151.0	2EJEC@1|root,33D5C@2|Bacteria,3Y8U5@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_563700_63	459349.CLOAM0520	5.551e-08	66.0	COG1404@1|root,COG4733@1|root,COG4932@1|root,COG1404@2|Bacteria,COG4733@2|Bacteria,COG4932@2|Bacteria,2NREM@2323|unclassified Bacteria	2|Bacteria	O	Evidence 5 No homology to any previously reported sequences	J	-	-	ko:K14194,ko:K21449	ko05150,map05150	-	-	-	ko00000,ko00001,ko02000	1.B.40.2	-	-	DUF1983,DUF3672,Phage-tail_3,SdrD_B
HKD3_k127_563700_46	497964.CfE428DRAFT_4983	2.809e-42	162.0	COG0741@1|root,COG0741@2|Bacteria,46W79@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Transglycosylase SLT domain	mltE	-	-	ko:K08309	-	-	-	-	ko00000,ko01000,ko01011	-	GH23	-	SLT
HKD3_k127_563700_4	240016.ABIZ01000001_gene4727	3.933e-242	772.0	COG1198@1|root,COG1198@2|Bacteria,46U3N@74201|Verrucomicrobia,2ITWU@203494|Verrucomicrobiae	203494|Verrucomicrobiae	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	-	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,ResIII
HKD3_k127_563700_34	401053.AciPR4_3731	2.669e-65	232.0	COG3222@1|root,COG3222@2|Bacteria,3Y5T4@57723|Acidobacteria,2JKE7@204432|Acidobacteriia	204432|Acidobacteriia	S	Uncharacterized protein conserved in bacteria (DUF2064)	-	-	-	ko:K09931	-	-	-	-	ko00000	-	-	-	DUF2064
HKD3_k127_563700_9	926566.Terro_3535	2.542e-173	550.0	COG0451@1|root,COG0451@2|Bacteria,3Y3CF@57723|Acidobacteria	57723|Acidobacteria	GM	PFAM NAD-dependent epimerase dehydratase	-	-	5.1.3.25	ko:K17947	ko00523,ko01130,map00523,map01130	-	R10279	RC00289	ko00000,ko00001,ko01000	-	-	-	Epimerase
HKD3_k127_563700_23	497964.CfE428DRAFT_2026	3.418e-101	343.0	COG2239@1|root,COG2239@2|Bacteria	2|Bacteria	P	Acts as a magnesium transporter	mgtE1	-	-	ko:K06213	-	-	-	-	ko00000,ko02000	1.A.26.1	-	-	CBS,MgtE,MgtE_N,PRC
HKD3_k127_563700_32	426117.M446_4901	4.755e-71	246.0	COG0463@1|root,COG0463@2|Bacteria,1RKJM@1224|Proteobacteria,2UANV@28211|Alphaproteobacteria,1JU6I@119045|Methylobacteriaceae	28211|Alphaproteobacteria	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HKD3_k127_563700_30	414684.RC1_2019	8.125e-81	275.0	COG3751@1|root,COG3751@2|Bacteria,1R4BC@1224|Proteobacteria,2U2Q5@28211|Alphaproteobacteria,2JYT8@204441|Rhodospirillales	204441|Rhodospirillales	O	2OG-Fe(II) oxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	2OG-FeII_Oxy_3
HKD3_k127_563700_39	671143.DAMO_1640	9.953e-59	218.0	COG0859@1|root,COG0859@2|Bacteria	2|Bacteria	M	ADP-heptose-lipopolysaccharide heptosyltransferase activity	-	-	-	ko:K02841,ko:K02843,ko:K02849,ko:K12982	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9
HKD3_k127_563700_28	525904.Tter_0584	5.179e-87	307.0	COG2041@1|root,COG2041@2|Bacteria,2NQ7J@2323|unclassified Bacteria	2|Bacteria	S	Oxidoreductase molybdopterin binding domain	yedY	-	1.8.3.1	ko:K00387,ko:K07147	ko00920,ko01100,ko01120,map00920,map01100,map01120	-	R00533	RC00168	ko00000,ko00001,ko01000	-	-	-	Mo-co_dimer,Oxidored_molyb
HKD3_k127_563700_19	1382359.JIAL01000001_gene1052	3.982e-108	358.0	COG0492@1|root,COG0492@2|Bacteria,3Y2W6@57723|Acidobacteria,2JIIK@204432|Acidobacteriia	204432|Acidobacteriia	C	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
HKD3_k127_563700_16	497964.CfE428DRAFT_5119	5.469e-133	435.0	COG0438@1|root,COG0438@2|Bacteria,46U7I@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
HKD3_k127_563700_29	497964.CfE428DRAFT_5121	1.543e-86	291.0	COG0454@1|root,COG0456@2|Bacteria,46V3S@74201|Verrucomicrobia	74201|Verrucomicrobia	K	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_563700_41	13035.Dacsa_2585	9.706e-52	198.0	COG3210@1|root,COG4625@1|root,COG3210@2|Bacteria,COG4625@2|Bacteria,1GPZ7@1117|Cyanobacteria	2|Bacteria	U	Parallel beta-helix repeats	mshQ	-	-	ko:K12287	-	-	-	-	ko00000,ko02044	-	-	-	Laminin_G_3,PATR
HKD3_k127_563700_40	1183438.GKIL_3396	2.701e-56	202.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K02405	ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111	-	-	-	ko00000,ko00001,ko02035,ko03021	-	-	-	Sigma70_ECF
HKD3_k127_563700_17	204669.Acid345_2395	8.94e-117	411.0	COG0457@1|root,COG0515@1|root,COG5616@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG5616@2|Bacteria	2|Bacteria	S	cAMP biosynthetic process	-	-	2.7.11.1	ko:K08282,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_16,TPR_2,TPR_8
HKD3_k127_563700_51	570952.ATVH01000015_gene1235	3.107e-34	136.0	COG1959@1|root,COG1959@2|Bacteria,1N05H@1224|Proteobacteria,2UBZM@28211|Alphaproteobacteria,2JT74@204441|Rhodospirillales	204441|Rhodospirillales	K	transcriptional regulator	-	-	-	ko:K13771	ko05132,map05132	-	-	-	ko00000,ko00001,ko03000	-	-	-	Rrf2
HKD3_k127_563700_35	118173.KB235914_gene303	1.308e-64	228.0	COG2846@1|root,COG2846@2|Bacteria,1GBB9@1117|Cyanobacteria	1117|Cyanobacteria	D	Di-iron-containing protein involved in the repair of iron-sulfur clusters	-	-	-	ko:K07322	-	-	-	-	ko00000	-	-	-	Hemerythrin,ScdA_N
HKD3_k127_563700_45	1266925.JHVX01000002_gene1045	1.66e-42	161.0	COG3189@1|root,COG3189@2|Bacteria,1MZ7H@1224|Proteobacteria,2VUKU@28216|Betaproteobacteria,373FF@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Protein of unknown function, DUF488	-	-	-	-	-	-	-	-	-	-	-	-	DUF488
HKD3_k127_563700_26	383372.Rcas_0817	6.803e-95	320.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
HKD3_k127_563700_24	1128421.JAGA01000003_gene2922	1.207e-98	328.0	COG0479@1|root,COG0479@2|Bacteria,2NPY8@2323|unclassified Bacteria	2|Bacteria	C	TIGRFAM succinate dehydrogenase and fumarate reductase iron-sulfur protein	sdhB	-	1.3.5.1,1.3.5.4	ko:K00240,ko:K00245	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020	M00009,M00011,M00149,M00150,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_3,Fer4_7,Fer4_8
HKD3_k127_563700_5	452637.Oter_1019	4.764e-231	725.0	COG2132@1|root,COG2132@2|Bacteria,46UN4@74201|Verrucomicrobia	74201|Verrucomicrobia	C	Multicopper oxidase	-	-	1.7.2.1	ko:K00368	ko00910,ko01120,map00910,map01120	M00529	R00783,R00785	RC00086	ko00000,ko00001,ko00002,ko01000	-	-	-	Cu-oxidase_3
HKD3_k127_563700_42	1232410.KI421426_gene1437	2.28e-50	186.0	arCOG11509@1|root,31KIR@2|Bacteria,1RGVE@1224|Proteobacteria,42T74@68525|delta/epsilon subdivisions,2WPQ8@28221|Deltaproteobacteria,43UQJ@69541|Desulfuromonadales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_563700_31	1254432.SCE1572_18470	3.044e-80	273.0	COG4122@1|root,COG4122@2|Bacteria,1R4VI@1224|Proteobacteria,42VVN@68525|delta/epsilon subdivisions,2WRTH@28221|Deltaproteobacteria,2YVK4@29|Myxococcales	28221|Deltaproteobacteria	S	O-methyltransferase	-	-	2.1.1.104	ko:K00588	ko00360,ko00940,ko00941,ko00945,ko01100,ko01110,map00360,map00940,map00941,map00945,map01100,map01110	M00039,M00350	R01942,R06578	RC00003,RC00392	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_3
HKD3_k127_563700_38	497964.CfE428DRAFT_6017	6.171e-59	211.0	COG1432@1|root,COG1432@2|Bacteria	2|Bacteria	S	NYN domain	-	-	-	-	-	-	-	-	-	-	-	-	CSD,NYN
HKD3_k127_563700_60	497964.CfE428DRAFT_6679	1.419e-12	70.0	COG1758@1|root,COG1758@2|Bacteria,46T94@74201|Verrucomicrobia	74201|Verrucomicrobia	K	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits	-	-	2.7.7.6	ko:K03060	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb6
HKD3_k127_563700_64	1268622.AVS7_00299	1.064e-07	66.0	2BW81@1|root,32UWZ@2|Bacteria,1MZGZ@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_595542_3	497964.CfE428DRAFT_6592	4.101e-11	66.0	COG1960@1|root,COG1960@2|Bacteria,46TJY@74201|Verrucomicrobia	74201|Verrucomicrobia	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HKD3_k127_595542_1	497964.CfE428DRAFT_0325	1.2e-112	394.0	COG1729@1|root,COG1729@2|Bacteria,46T9I@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16
HKD3_k127_595542_0	497964.CfE428DRAFT_0324	0.0	1425.0	COG0178@1|root,COG0178@2|Bacteria,46SEB@74201|Verrucomicrobia	74201|Verrucomicrobia	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	-	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
HKD3_k127_595542_2	1173264.KI913949_gene245	9.983e-17	85.0	COG0500@1|root,COG1215@1|root,COG1215@2|Bacteria,COG2226@2|Bacteria,1G3PF@1117|Cyanobacteria,1HHPG@1150|Oscillatoriales	1117|Cyanobacteria	MQ	Methionine biosynthesis protein MetW	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2,Methyltransf_12,Methyltransf_23,Methyltransf_25
HKD3_k127_6041874_19	497964.CfE428DRAFT_0539	9.026e-39	147.0	COG1403@1|root,COG1403@2|Bacteria,46SMP@74201|Verrucomicrobia	74201|Verrucomicrobia	L	HNH endonuclease	mcrA	-	-	-	-	-	-	-	-	-	-	-	HNH_5
HKD3_k127_6041874_8	1396141.BATP01000059_gene2526	2.843e-113	376.0	COG0435@1|root,COG0435@2|Bacteria,46S81@74201|Verrucomicrobia,2IV4Q@203494|Verrucomicrobiae	203494|Verrucomicrobiae	O	Glutathione S-transferase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	GST_C_2,GST_N_2
HKD3_k127_6041874_6	877455.Metbo_1301	1.434e-150	489.0	arCOG02685@1|root,arCOG02685@2157|Archaea,2XV10@28890|Euryarchaeota	28890|Euryarchaeota	G	COG0477 Permeases of the major facilitator superfamily	csbC	-	-	-	-	-	-	-	-	-	-	-	Sugar_tr
HKD3_k127_6041874_2	497964.CfE428DRAFT_0836	2.152e-283	889.0	COG3808@1|root,COG3808@2|Bacteria,46S7R@74201|Verrucomicrobia	74201|Verrucomicrobia	C	Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
HKD3_k127_6041874_12	1396141.BATP01000003_gene5111	8.344e-67	240.0	COG0745@1|root,COG1235@1|root,COG2203@1|root,COG0745@2|Bacteria,COG1235@2|Bacteria,COG2203@2|Bacteria,46UKB@74201|Verrucomicrobia,2IVU2@203494|Verrucomicrobiae	203494|Verrucomicrobiae	KT	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2,Response_reg
HKD3_k127_6041874_17	1396141.BATP01000026_gene1023	8.325e-46	171.0	COG1376@1|root,COG1376@2|Bacteria,46VEG@74201|Verrucomicrobia,2IVY0@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	L,D-transpeptidase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	YkuD
HKD3_k127_6041874_14	335543.Sfum_3682	3.932e-65	231.0	COG2930@1|root,COG2930@2|Bacteria,1RHV6@1224|Proteobacteria,42TN0@68525|delta/epsilon subdivisions,2WQ75@28221|Deltaproteobacteria,2MQM3@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Las17-binding protein actin regulator	-	-	-	-	-	-	-	-	-	-	-	-	Ysc84
HKD3_k127_6041874_25	497964.CfE428DRAFT_6257	2.65e-21	97.0	2CDIR@1|root,348KT@2|Bacteria,46W4H@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_6041874_15	497964.CfE428DRAFT_0566	4.991e-61	214.0	COG0590@1|root,COG0590@2|Bacteria,46SZZ@74201|Verrucomicrobia	74201|Verrucomicrobia	FJ	Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)	tadA	-	3.5.4.33	ko:K11991	-	-	R10223	RC00477	ko00000,ko01000,ko03016	-	-	-	MafB19-deam
HKD3_k127_6041874_1	1403819.BATR01000021_gene737	5e-324	1001.0	COG0365@1|root,COG0365@2|Bacteria,46SBX@74201|Verrucomicrobia,2ITZ8@203494|Verrucomicrobiae	203494|Verrucomicrobiae	I	Acetyl-coenzyme A synthetase N-terminus	-	-	-	-	-	-	-	-	-	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
HKD3_k127_6041874_18	497964.CfE428DRAFT_4097	9.256e-40	159.0	COG2173@1|root,COG2173@2|Bacteria,46VUM@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide	-	-	3.4.13.22	ko:K08641	ko01502,ko02020,map01502,map02020	M00651	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504	-	-	-	Peptidase_M15
HKD3_k127_6041874_20	1156937.MFUM_920020	9.853e-33	132.0	2AG58@1|root,3169Z@2|Bacteria,46WMP@74201|Verrucomicrobia,37GPD@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_6041874_7	861299.J421_1133	1.956e-139	457.0	COG0531@1|root,COG0531@2|Bacteria	2|Bacteria	E	amino acid	gadC	GO:0003333,GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0006865,GO:0006873,GO:0006885,GO:0008150,GO:0008509,GO:0008514,GO:0009987,GO:0015075,GO:0015171,GO:0015179,GO:0015291,GO:0015297,GO:0015318,GO:0015711,GO:0015807,GO:0015849,GO:0016020,GO:0016021,GO:0019725,GO:0022804,GO:0022857,GO:0030003,GO:0030004,GO:0030641,GO:0031224,GO:0031226,GO:0034220,GO:0042592,GO:0044425,GO:0044459,GO:0044464,GO:0045852,GO:0046942,GO:0046943,GO:0048878,GO:0050801,GO:0051179,GO:0051234,GO:0051453,GO:0051454,GO:0055067,GO:0055080,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071702,GO:0071705,GO:0071944,GO:0098656,GO:0098771,GO:1902475,GO:1903825,GO:1905039	-	ko:K20265	ko02024,map02024	-	-	-	ko00000,ko00001,ko02000	2.A.3.7.1,2.A.3.7.3	-	iEC042_1314.EC042_1624	AA_permease_2
HKD3_k127_6041874_21	1403819.BATR01000021_gene748	1.205e-27	115.0	COG1324@1|root,COG1324@2|Bacteria,46TAD@74201|Verrucomicrobia,2IUTN@203494|Verrucomicrobiae	203494|Verrucomicrobiae	P	CutA1 divalent ion tolerance protein	-	-	-	-	-	-	-	-	-	-	-	-	CutA1
HKD3_k127_6041874_5	497964.CfE428DRAFT_4701	7.123e-170	541.0	COG0482@1|root,COG0482@2|Bacteria,46SQW@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34	mnmA	-	2.8.1.13	ko:K00566	ko04122,map04122	-	R08700	RC02313,RC02315	ko00000,ko00001,ko01000,ko03016	-	-	-	tRNA_Me_trans
HKD3_k127_6041874_16	497964.CfE428DRAFT_0750	1.111e-57	206.0	COG2094@1|root,COG2094@2|Bacteria,46VAR@74201|Verrucomicrobia	74201|Verrucomicrobia	L	Methylpurine-DNA glycosylase (MPG)	-	-	-	-	-	-	-	-	-	-	-	-	Pur_DNA_glyco
HKD3_k127_6041874_28	1449049.JONW01000005_gene1088	6.632e-05	53.0	COG0810@1|root,COG0810@2|Bacteria	2|Bacteria	M	energy transducer activity	-	-	-	-	-	-	-	-	-	-	-	-	CarbopepD_reg_2,Peptidase_M56,TonB_C
HKD3_k127_6041874_9	1396141.BATP01000022_gene358	8.988e-111	378.0	COG0737@1|root,COG0737@2|Bacteria,46X8F@74201|Verrucomicrobia,2IV06@203494|Verrucomicrobiae	203494|Verrucomicrobiae	F	Calcineurin-like phosphoesterase	-	-	3.1.3.5	ko:K01081	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	5_nucleotid_C,Metallophos
HKD3_k127_6041874_4	1123248.KB893323_gene1603	3.728e-244	761.0	COG0277@1|root,COG0277@2|Bacteria,4NHFC@976|Bacteroidetes,1IUJ0@117747|Sphingobacteriia	976|Bacteroidetes	C	FAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	BBE,DUF805,FAD_binding_4
HKD3_k127_6041874_11	713586.KB900536_gene464	8.823e-68	235.0	COG1765@1|root,COG1765@2|Bacteria,1R9XU@1224|Proteobacteria,1SB92@1236|Gammaproteobacteria,1X0XT@135613|Chromatiales	135613|Chromatiales	O	OsmC-like protein	-	-	-	-	-	-	-	-	-	-	-	-	OsmC
HKD3_k127_6041874_13	216596.RL2316	2.266e-66	241.0	COG2114@1|root,COG2114@2|Bacteria,1N6I7@1224|Proteobacteria,2U3M0@28211|Alphaproteobacteria,4B8MG@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	Adenylate cyclase, family 3 (some proteins contain HAMP domain)	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF4242,Guanylate_cyc
HKD3_k127_6041874_24	485913.Krac_10582	3.781e-24	108.0	COG0346@1|root,COG0346@2|Bacteria	2|Bacteria	E	lactoylglutathione lyase activity	-	-	-	ko:K11210	-	-	-	-	ko00000,ko01000	-	-	-	Glyoxalase
HKD3_k127_6041874_0	497964.CfE428DRAFT_4464	0.0	1451.0	COG0653@1|root,COG0653@2|Bacteria,46SJC@74201|Verrucomicrobia	74201|Verrucomicrobia	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	-	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
HKD3_k127_6041874_10	497964.CfE428DRAFT_6620	1.929e-70	243.0	COG2360@1|root,COG2360@2|Bacteria,46VHR@74201|Verrucomicrobia	74201|Verrucomicrobia	O	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine	aat	-	2.3.2.6	ko:K00684	-	-	R03813,R11443,R11444	RC00055,RC00064	ko00000,ko01000	-	-	-	Leu_Phe_trans
HKD3_k127_6041874_3	497964.CfE428DRAFT_6618	3.312e-260	809.0	COG0519@1|root,COG0519@2|Bacteria,46SIW@74201|Verrucomicrobia	74201|Verrucomicrobia	F	Catalyzes the synthesis of GMP from XMP	guaA	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase,GMP_synt_C,NAD_synthase
HKD3_k127_6051008_1	204669.Acid345_4193	2.466e-139	445.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,3Y3IB@57723|Acidobacteria,2JKJ2@204432|Acidobacteriia	204432|Acidobacteriia	EU	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
HKD3_k127_6051008_6	497964.CfE428DRAFT_2282	1.683e-65	229.0	COG1376@1|root,COG1376@2|Bacteria,46VEG@74201|Verrucomicrobia	74201|Verrucomicrobia	S	PFAM ErfK YbiS YcfS YnhG family protein	-	-	-	-	-	-	-	-	-	-	-	-	YkuD
HKD3_k127_6051008_2	497964.CfE428DRAFT_4598	3.816e-138	446.0	COG2876@1|root,COG2876@2|Bacteria,46SUJ@74201|Verrucomicrobia	74201|Verrucomicrobia	E	PFAM DAHP synthetase I KDSA	-	-	2.5.1.54	ko:K03856	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_1
HKD3_k127_6051008_0	1123070.KB899252_gene912	4.716e-303	963.0	COG1197@1|root,COG1197@2|Bacteria,46S6Y@74201|Verrucomicrobia,2ITM9@203494|Verrucomicrobiae	203494|Verrucomicrobiae	L	TRCF	-	-	-	-	-	-	-	-	-	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
HKD3_k127_6051008_5	497964.CfE428DRAFT_2349	9.856e-75	265.0	COG0760@1|root,COG0760@2|Bacteria,46SU4@74201|Verrucomicrobia	74201|Verrucomicrobia	M	PFAM PpiC-type peptidyl-prolyl cis-trans isomerase	-	-	5.2.1.8	ko:K03771	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_2,Rotamase_3,SurA_N_3
HKD3_k127_6051008_3	497964.CfE428DRAFT_2348	5.028e-117	383.0	COG1995@1|root,COG1995@2|Bacteria,46SNQ@74201|Verrucomicrobia	74201|Verrucomicrobia	C	Belongs to the PdxA family	pdxA	-	1.1.1.262,1.1.1.408,1.1.1.409	ko:K00097,ko:K22024	ko00750,ko01100,map00750,map01100	M00124	R05681,R05837,R07406	RC00089,RC00675,RC01475	ko00000,ko00001,ko00002,ko01000	-	-	-	PdxA
HKD3_k127_6051008_4	497964.CfE428DRAFT_2347	9.359e-89	299.0	COG4587@1|root,COG4587@2|Bacteria,46VAG@74201|Verrucomicrobia	74201|Verrucomicrobia	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_6
HKD3_k127_6059869_1	456442.Mboo_0933	8.55e-94	320.0	COG0218@1|root,arCOG00355@2157|Archaea	2157|Archaea	D	Necessary for normal cell division and for the maintenance of normal septation	engB	-	-	-	-	-	-	-	-	-	-	-	MMR_HSR1
HKD3_k127_6059869_0	880072.Desac_2753	2.074e-126	418.0	COG0475@1|root,COG0475@2|Bacteria,1R7K4@1224|Proteobacteria	1224|Proteobacteria	P	COG0475 Kef-type K transport systems, membrane components	-	-	-	ko:K03455	-	-	-	-	ko00000	2.A.37	-	-	Na_H_Exchanger
HKD3_k127_6059869_2	1156937.MFUM_200037	4.442e-22	96.0	COG1137@1|root,COG1137@2|Bacteria,46SDI@74201|Verrucomicrobia,37FW2@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	S	ABC transporter	-	-	-	ko:K06861	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	1.B.42.1	-	-	ABC_tran
HKD3_k127_6081713_19	246197.MXAN_2622	8.246e-84	284.0	COG3361@1|root,COG3361@2|Bacteria	2|Bacteria	S	conserved protein (COG2071)	-	-	-	ko:K09166	-	-	-	-	ko00000	-	-	-	DUF2071
HKD3_k127_6081713_20	497964.CfE428DRAFT_0336	3.406e-80	293.0	COG0457@1|root,COG1196@1|root,COG0457@2|Bacteria,COG1196@2|Bacteria,46T1H@74201|Verrucomicrobia	2|Bacteria	D	Tetratricopeptide TPR_2 repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	Mob_Pre,TPR_11
HKD3_k127_6081713_14	497964.CfE428DRAFT_3687	3.672e-123	403.0	COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,46SFQ@74201|Verrucomicrobia	74201|Verrucomicrobia	H	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate	ribD	-	1.1.1.193,3.5.4.26	ko:K11752	ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024	M00125	R03458,R03459	RC00204,RC00933	ko00000,ko00001,ko00002,ko01000	-	-	-	RibD_C,dCMP_cyt_deam_1
HKD3_k127_6081713_12	716544.wcw_1949	1.911e-150	498.0	COG0568@1|root,COG0568@2|Bacteria,2JFP5@204428|Chlamydiae	204428|Chlamydiae	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	sigA	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
HKD3_k127_6081713_7	497964.CfE428DRAFT_1568	2.495e-185	597.0	COG0358@1|root,COG0358@2|Bacteria,46S6C@74201|Verrucomicrobia	74201|Verrucomicrobia	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB_bind,Toprim_2,Toprim_N,zf-CHC2
HKD3_k127_6081713_22	478741.JAFS01000002_gene444	3.183e-77	276.0	COG1030@1|root,COG1030@2|Bacteria,46TAS@74201|Verrucomicrobia,37G9H@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	O	NfeD-like C-terminal, partner-binding	-	-	-	ko:K07403	-	-	-	-	ko00000	-	-	-	NfeD,SDH_sah
HKD3_k127_6081713_38	391596.PBAL39_17904	0.0001461	47.0	COG2104@1|root,COG2104@2|Bacteria,4NX2F@976|Bacteroidetes	976|Bacteroidetes	H	thiamine biosynthesis protein ThiS	thiS	-	-	ko:K03154	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
HKD3_k127_6081713_11	497964.CfE428DRAFT_1577	2.547e-153	495.0	COG0502@1|root,COG0502@2|Bacteria,46SFX@74201|Verrucomicrobia	74201|Verrucomicrobia	H	Biotin and Thiamin Synthesis associated domain	-	-	4.1.99.19	ko:K03150	ko00730,ko01100,map00730,map01100	-	R10246	RC01434,RC03095	ko00000,ko00001,ko01000	-	-	-	BATS,Radical_SAM
HKD3_k127_6081713_3	497964.CfE428DRAFT_3932	9.128e-258	802.0	COG1530@1|root,COG1530@2|Bacteria,46S5S@74201|Verrucomicrobia	74201|Verrucomicrobia	J	TIGRFAM ribonuclease, Rne Rng family	cafA	-	-	ko:K08301	-	-	-	-	ko00000,ko01000,ko03009,ko03019	-	-	-	RNase_E_G
HKD3_k127_6081713_2	497964.CfE428DRAFT_3931	1.116e-273	863.0	COG0768@1|root,COG0768@2|Bacteria,46SE6@74201|Verrucomicrobia	74201|Verrucomicrobia	M	PFAM penicillin-binding protein transpeptidase	-	-	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	-	PBP_dimer,Peptidase_M56,Transpeptidase
HKD3_k127_6081713_27	497964.CfE428DRAFT_3930	8.149e-44	168.0	290WN@1|root,2ZNIF@2|Bacteria,46WW0@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_6081713_21	497964.CfE428DRAFT_3929	5.124e-80	275.0	COG1792@1|root,COG1792@2|Bacteria,46T2J@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Involved in formation and maintenance of cell shape	mreC	-	-	ko:K03570	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreC
HKD3_k127_6081713_8	1403819.BATR01000133_gene4729	1.402e-177	560.0	COG1077@1|root,COG1077@2|Bacteria,46SAA@74201|Verrucomicrobia,2ITYI@203494|Verrucomicrobiae	203494|Verrucomicrobiae	D	Actin	-	-	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
HKD3_k127_6081713_23	452637.Oter_4448	1.43e-72	251.0	COG0036@1|root,COG0036@2|Bacteria,46TEK@74201|Verrucomicrobia,3K7FI@414999|Opitutae	2|Bacteria	G	Belongs to the ribulose-phosphate 3-epimerase family	rpe	GO:0003674,GO:0003824,GO:0004750,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009052,GO:0009056,GO:0009117,GO:0009987,GO:0016052,GO:0016853,GO:0016854,GO:0016857,GO:0019321,GO:0019323,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046483,GO:0046496,GO:0046872,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564,GO:1901575	5.1.3.1	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
HKD3_k127_6081713_4	497964.CfE428DRAFT_5092	8.698e-233	733.0	COG2804@1|root,COG2804@2|Bacteria,46TUR@74201|Verrucomicrobia	74201|Verrucomicrobia	NU	Type II/IV secretion system protein	-	-	-	-	-	-	-	-	-	-	-	-	T2SSE,T2SSE_N
HKD3_k127_6081713_37	1403819.BATR01000092_gene2748	1.386e-05	53.0	2E3AC@1|root,32Y9V@2|Bacteria	2|Bacteria	S	Putative peptidoglycan binding domain	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_1
HKD3_k127_6081713_9	497964.CfE428DRAFT_5085	6.311e-175	576.0	COG1450@1|root,COG1450@2|Bacteria,46UJ6@74201|Verrucomicrobia	74201|Verrucomicrobia	NU	Bacterial type II/III secretion system short domain	-	-	-	-	-	-	-	-	-	-	-	-	Secretin,Secretin_N
HKD3_k127_6081713_29	1122604.JONR01000014_gene308	1.769e-34	140.0	COG4319@1|root,COG4319@2|Bacteria,1MZRB@1224|Proteobacteria,1SC2M@1236|Gammaproteobacteria,1X88I@135614|Xanthomonadales	135614|Xanthomonadales	S	Domain of unknown function (DUF4440)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440
HKD3_k127_6081713_5	497964.CfE428DRAFT_4279	2.179e-204	645.0	COG0773@1|root,COG0773@2|Bacteria,46THM@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Mur ligase middle domain protein	-	-	6.3.2.45	ko:K02558	-	-	-	-	ko00000,ko01000	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
HKD3_k127_6081713_15	1396418.BATQ01000073_gene506	3.406e-112	388.0	COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,46V2N@74201|Verrucomicrobia,2IVVG@203494|Verrucomicrobiae	203494|Verrucomicrobiae	T	CHASE2	-	-	-	-	-	-	-	-	-	-	-	-	CHASE2,Guanylate_cyc
HKD3_k127_6081713_26	497964.CfE428DRAFT_4433	4.326e-47	173.0	COG0292@1|root,COG0292@2|Bacteria,46SZW@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit	rplT	-	-	ko:K02887	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L20
HKD3_k127_6081713_13	497964.CfE428DRAFT_4430	1.065e-142	460.0	COG0016@1|root,COG0016@2|Bacteria,46S6R@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily	pheS	-	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Phe_tRNA-synt_N,tRNA-synt_2d
HKD3_k127_6081713_6	1396418.BATQ01000142_gene3288	3.044e-203	659.0	COG0072@1|root,COG0072@2|Bacteria,46SDG@74201|Verrucomicrobia,2ITHP@203494|Verrucomicrobiae	203494|Verrucomicrobiae	J	B3/4 domain	pheT	-	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,tRNA_bind
HKD3_k127_6081713_10	1403819.BATR01000184_gene6355	1.295e-170	543.0	COG0505@1|root,COG0505@2|Bacteria,46TDX@74201|Verrucomicrobia,2ITTA@203494|Verrucomicrobiae	203494|Verrucomicrobiae	F	Carbamoyl-phosphate synthase small chain, CPSase domain	carA	-	6.3.5.5	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_sm_chain,GATase
HKD3_k127_6081713_31	481448.Minf_0191	2.763e-22	102.0	2CK2Q@1|root,329IJ@2|Bacteria,46ZCM@74201|Verrucomicrobia,37GU0@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_6081713_0	136993.KB900626_gene3898	0.0	1603.0	COG1201@1|root,COG1201@2|Bacteria,1MUSW@1224|Proteobacteria,2TR7V@28211|Alphaproteobacteria,36X8N@31993|Methylocystaceae	28211|Alphaproteobacteria	L	DEAD/H associated	lhr	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,Helicase_C
HKD3_k127_6081713_24	1499967.BAYZ01000017_gene6259	1.693e-56	205.0	COG1215@1|root,COG1215@2|Bacteria,2NPW4@2323|unclassified Bacteria	2|Bacteria	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HKD3_k127_6081713_16	485918.Cpin_1576	3.803e-112	373.0	COG1446@1|root,COG1446@2|Bacteria,4NF1U@976|Bacteroidetes,1IQI3@117747|Sphingobacteriia	976|Bacteroidetes	E	Asparaginase	-	-	3.4.19.5	ko:K13051	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Asparaginase_2
HKD3_k127_6081713_18	497964.CfE428DRAFT_3183	3.251e-88	299.0	COG0767@1|root,COG0767@2|Bacteria,46SY3@74201|Verrucomicrobia	74201|Verrucomicrobia	Q	Belongs to the MlaE permease family	-	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE
HKD3_k127_6081713_17	497964.CfE428DRAFT_3184	6.223e-96	321.0	COG1127@1|root,COG1127@2|Bacteria,46SRC@74201|Verrucomicrobia	74201|Verrucomicrobia	Q	PFAM ABC transporter related	-	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
HKD3_k127_6081713_35	608538.HTH_1768	4.44e-09	68.0	COG1463@1|root,COG1463@2|Bacteria,2G3I1@200783|Aquificae	200783|Aquificae	Q	Mammalian cell entry related domain protein	-	-	-	ko:K02067	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaD
HKD3_k127_6081713_1	497964.CfE428DRAFT_0348	5e-324	1013.0	COG0612@1|root,COG0612@2|Bacteria,46S9I@74201|Verrucomicrobia	74201|Verrucomicrobia	S	PFAM peptidase M16 domain protein	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
HKD3_k127_6081713_28	497964.CfE428DRAFT_0347	5.954e-42	159.0	2E5IJ@1|root,3309Y@2|Bacteria,46SYV@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_6081713_25	497964.CfE428DRAFT_2285	4.823e-51	197.0	2C7EB@1|root,347YC@2|Bacteria,46W4Z@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_6084259_6	1403819.BATR01000002_gene18	6.844e-64	225.0	COG0352@1|root,COG0352@2|Bacteria,46T6K@74201|Verrucomicrobia,2IUF9@203494|Verrucomicrobiae	203494|Verrucomicrobiae	H	Thiamine monophosphate synthase	-	-	2.5.1.3	ko:K00788	ko00730,ko01100,map00730,map01100	M00127	R03223,R10712	RC00224,RC03255,RC03397	ko00000,ko00001,ko00002,ko01000	-	-	-	TMP-TENI
HKD3_k127_6084259_0	497964.CfE428DRAFT_2953	9.669e-217	680.0	COG0439@1|root,COG0439@2|Bacteria,46SIE@74201|Verrucomicrobia	74201|Verrucomicrobia	I	acetyl-CoA carboxylase	-	-	6.3.4.14,6.4.1.2	ko:K01961	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04385	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
HKD3_k127_6084259_7	497964.CfE428DRAFT_2954	7.896e-43	161.0	COG0511@1|root,COG0511@2|Bacteria,46SXA@74201|Verrucomicrobia	74201|Verrucomicrobia	I	first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA	accB	-	-	ko:K02160	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742	RC00040,RC00367	ko00000,ko00001,ko00002	-	-	-	Biotin_lipoyl
HKD3_k127_6084259_3	497964.CfE428DRAFT_4120	2.485e-88	298.0	COG0564@1|root,COG0564@2|Bacteria,46V2B@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Pseudouridine synthase	-	-	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2
HKD3_k127_6084259_11	748247.AZKH_3370	8.277e-13	79.0	2F2FR@1|root,33VD5@2|Bacteria,1NUHA@1224|Proteobacteria,2W28U@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Lipid A 3-O-deacylase (PagL)	-	-	-	-	-	-	-	-	-	-	-	-	PagL
HKD3_k127_6084259_5	497964.CfE428DRAFT_0921	9.933e-76	259.0	COG4112@1|root,COG4112@2|Bacteria,46V3C@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_6084259_10	1244869.H261_00495	2.158e-13	74.0	2EG0F@1|root,339SF@2|Bacteria,1NJRZ@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_6084259_2	502025.Hoch_5542	1.528e-111	376.0	COG0501@1|root,COG0501@2|Bacteria,1MUXT@1224|Proteobacteria,42P1M@68525|delta/epsilon subdivisions,2WKJ2@28221|Deltaproteobacteria,2Z11I@29|Myxococcales	28221|Deltaproteobacteria	M	CAAX prenyl protease N-terminal, five membrane helices	-	-	3.4.24.84	ko:K06013	ko00900,ko01130,map00900,map01130	-	R09845	RC00141	ko00000,ko00001,ko01000,ko01002,ko04147	-	-	-	Peptidase_M48,Peptidase_M48_N
HKD3_k127_6084259_8	469617.FUAG_01663	1.686e-25	110.0	COG3952@1|root,COG3952@2|Bacteria,37AN1@32066|Fusobacteria	32066|Fusobacteria	S	Lipid A Biosynthesis N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	LAB_N
HKD3_k127_6084259_4	1123354.AUDR01000001_gene2018	1.666e-82	280.0	COG0463@1|root,COG0463@2|Bacteria,1MWE5@1224|Proteobacteria,2VJ5G@28216|Betaproteobacteria,1KRK3@119069|Hydrogenophilales	1224|Proteobacteria	M	Glycosyl transferase family 2	arnC	GO:0000271,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009987,GO:0016051,GO:0030258,GO:0030259,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0070085,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2
HKD3_k127_6084259_1	1123354.AUDR01000001_gene2019	1.458e-166	530.0	COG0399@1|root,COG0399@2|Bacteria,1MUPN@1224|Proteobacteria,2VJDZ@28216|Betaproteobacteria,1KTB7@119069|Hydrogenophilales	119069|Hydrogenophilales	M	DegT/DnrJ/EryC1/StrS aminotransferase family	-	-	1.17.1.1	ko:K12452	ko00520,map00520	-	R03391,R03392	RC00230	ko00000,ko00001,ko01000	-	-	-	DegT_DnrJ_EryC1
HKD3_k127_6084259_9	391623.TERMP_01927	2.676e-17	90.0	COG0673@1|root,arCOG01622@2157|Archaea,2XTZY@28890|Euryarchaeota,243PQ@183968|Thermococci	183968|Thermococci	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	1.1.1.374	ko:K18855	-	-	-	-	ko00000,ko01000	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
HKD3_k127_6084479_19	1183438.GKIL_3588	8.338e-08	58.0	COG2234@1|root,COG2234@2|Bacteria	2|Bacteria	DZ	aminopeptidase activity	pgcp	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_M28
HKD3_k127_6084479_20	338963.Pcar_3033	1.654e-06	57.0	2CA8B@1|root,33XH7@2|Bacteria,1NVUZ@1224|Proteobacteria,4300U@68525|delta/epsilon subdivisions,2WV6E@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_6084479_15	1396418.BATQ01000091_gene5792	1.415e-43	164.0	2F83K@1|root,340H0@2|Bacteria,46VYE@74201|Verrucomicrobia,2IUSA@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Domain of unknown function (DUF5069)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5069
HKD3_k127_6084479_12	497964.CfE428DRAFT_2959	2.987e-80	274.0	2ED0A@1|root,336X9@2|Bacteria,46TCE@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_6084479_0	240016.ABIZ01000001_gene2935	1.04e-248	780.0	COG0173@1|root,COG0173@2|Bacteria,46S7W@74201|Verrucomicrobia,2ITZA@203494|Verrucomicrobiae	203494|Verrucomicrobiae	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
HKD3_k127_6084479_4	481448.Minf_0080	7.029e-135	441.0	COG0124@1|root,COG0124@2|Bacteria,46S7Y@74201|Verrucomicrobia,37G1T@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	J	Histidyl-tRNA synthetase	hisS	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
HKD3_k127_6084479_2	497964.CfE428DRAFT_0163	3.402e-203	645.0	COG0322@1|root,COG0322@2|Bacteria,46SAJ@74201|Verrucomicrobia	74201|Verrucomicrobia	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	-	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N
HKD3_k127_6084479_1	497964.CfE428DRAFT_4939	1.147e-237	752.0	COG0768@1|root,COG0768@2|Bacteria,46TSQ@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Penicillin-binding Protein dimerisation domain	-	-	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	-	PBP_dimer,Transpeptidase
HKD3_k127_6084479_6	478741.JAFS01000002_gene659	9.342e-126	411.0	COG0667@1|root,COG0667@2|Bacteria,46SYS@74201|Verrucomicrobia,37G4F@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
HKD3_k127_6084479_9	497964.CfE428DRAFT_2594	6.326e-100	332.0	COG2138@1|root,COG2138@2|Bacteria,46SPE@74201|Verrucomicrobia	74201|Verrucomicrobia	S	CbiX	-	-	4.99.1.3	ko:K03795	ko00860,ko01100,ko01120,map00860,map01100,map01120	-	R05807	RC01012	ko00000,ko00001,ko01000	-	-	-	CbiX
HKD3_k127_6084479_17	525904.Tter_2363	1.87e-20	97.0	COG1956@1|root,COG1956@2|Bacteria,2NPKF@2323|unclassified Bacteria	2|Bacteria	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	yebR	-	1.8.4.14	ko:K08968	ko00270,map00270	-	R02025	RC00639	ko00000,ko00001,ko01000	-	-	-	GAF,GAF_2
HKD3_k127_6084479_14	497964.CfE428DRAFT_2595	2.377e-50	187.0	COG2138@1|root,COG2138@2|Bacteria,46W9E@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Cobalamin (vitamin B12) biosynthesis CbiX protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_6084479_7	497964.CfE428DRAFT_2596	6.135e-118	393.0	COG0402@1|root,COG0402@2|Bacteria,46TB5@74201|Verrucomicrobia	74201|Verrucomicrobia	F	Amidohydrolase family	ssnA	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
HKD3_k127_6084479_3	497964.CfE428DRAFT_2602	1.558e-188	599.0	COG1508@1|root,COG1508@2|Bacteria,46SDZ@74201|Verrucomicrobia	74201|Verrucomicrobia	K	TIGRFAM RNA polymerase sigma-54 factor, RpoN	rpoN	-	-	ko:K03092	ko02020,ko05111,map02020,map05111	-	-	-	ko00000,ko00001,ko03021	-	-	-	Sigma54_AID,Sigma54_CBD,Sigma54_DBD
HKD3_k127_6084479_16	234267.Acid_5566	1.784e-25	115.0	COG0428@1|root,COG0428@2|Bacteria,3Y8C3@57723|Acidobacteria	57723|Acidobacteria	P	transporter	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_6084479_10	1449065.JMLL01000011_gene2169	2.896e-91	309.0	COG1230@1|root,COG1230@2|Bacteria,1MVQB@1224|Proteobacteria,2TSE3@28211|Alphaproteobacteria,43J8F@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	P	Cation efflux family	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux
HKD3_k127_6084479_13	1379698.RBG1_1C00001G0109	1.594e-74	260.0	COG1108@1|root,COG1108@2|Bacteria,2NQ6F@2323|unclassified Bacteria	2|Bacteria	U	ABC 3 transport family	znuB	-	-	ko:K02075,ko:K09816	ko02010,map02010	M00242,M00244	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15,3.A.1.15.3,3.A.1.15.5	-	-	ABC-3
HKD3_k127_6084479_11	247490.KSU1_D0783	3.104e-82	286.0	COG0803@1|root,COG0803@2|Bacteria,2J0IP@203682|Planctomycetes	203682|Planctomycetes	P	Zinc-uptake complex component A periplasmic	-	-	-	ko:K09815	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	ZnuA
HKD3_k127_6084479_5	247490.KSU1_D0782	1.009e-130	435.0	COG3170@1|root,COG3170@2|Bacteria,2J3MN@203682|Planctomycetes	203682|Planctomycetes	NU	Tfp pilus assembly protein FimV	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_6104647_0	497964.CfE428DRAFT_2523	0.0	1631.0	COG0209@1|root,COG0209@2|Bacteria,46SG4@74201|Verrucomicrobia	74201|Verrucomicrobia	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	-	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_2_N,Ribonuc_red_lgC
HKD3_k127_6104647_1	497964.CfE428DRAFT_6592	3.932e-247	774.0	COG1960@1|root,COG1960@2|Bacteria,46TJY@74201|Verrucomicrobia	74201|Verrucomicrobia	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HKD3_k127_6109663_5	497964.CfE428DRAFT_0418	1.379e-87	297.0	COG1573@1|root,COG1573@2|Bacteria,46SSB@74201|Verrucomicrobia	74201|Verrucomicrobia	L	TIGRFAM phage SPO1 DNA polymerase-related protein	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
HKD3_k127_6109663_7	1100721.ALKO01000003_gene2236	4.856e-80	279.0	COG1562@1|root,COG1562@2|Bacteria,1R4ZD@1224|Proteobacteria,2VQQ2@28216|Betaproteobacteria	28216|Betaproteobacteria	I	Squalene phytoene synthase	-	-	2.5.1.21	ko:K00801	ko00100,ko00909,ko01100,ko01110,ko01130,map00100,map00909,map01100,map01110,map01130	-	R00702,R02872,R06223	RC00362,RC00796,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	SQS_PSY
HKD3_k127_6109663_4	497964.CfE428DRAFT_0842	5.912e-91	310.0	COG2006@1|root,COG2006@2|Bacteria,46T4A@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
HKD3_k127_6109663_3	478741.JAFS01000002_gene821	5.437e-93	319.0	COG0635@1|root,COG0635@2|Bacteria,46STN@74201|Verrucomicrobia,37FV5@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	H	Involved in the biosynthesis of porphyrin-containing compound	hemN	-	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
HKD3_k127_6109663_1	497964.CfE428DRAFT_5681	1.183e-144	466.0	COG0836@1|root,COG0836@2|Bacteria,46SAQ@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Nucleotidyl transferase	manC	-	2.7.7.13	ko:K00971	ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110	M00114,M00361,M00362	R00885	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	MannoseP_isomer,NTP_transferase
HKD3_k127_6109663_9	621372.ACIH01000090_gene2944	1.99e-27	116.0	COG0816@1|root,COG0816@2|Bacteria,1V6ER@1239|Firmicutes,4HH04@91061|Bacilli,26XDH@186822|Paenibacillaceae	91061|Bacilli	L	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA	yrrK	GO:0000966,GO:0000967,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360	-	ko:K07447	-	-	-	-	ko00000,ko01000	-	-	-	RuvX
HKD3_k127_6109663_8	497964.CfE428DRAFT_5685	2.376e-73	254.0	COG0101@1|root,COG0101@2|Bacteria,46SSV@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs	truA	-	5.4.99.12	ko:K06173	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PseudoU_synth_1
HKD3_k127_6109663_12	1323663.AROI01000009_gene3658	1.799e-06	60.0	COG2909@1|root,COG2909@2|Bacteria,1MVZZ@1224|Proteobacteria,1RN29@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	Positively regulates the transcription of the maltose regulon whose gene products are responsible for uptake and catabolism of malto-oligosaccharides. Binds and recognizes a DNA motif (called the malT box) 5'-GGA TG GA-3'	acoK	-	-	ko:K03556	-	-	-	-	ko00000,ko03000	-	-	-	AAA_16,AAA_25,GerE,TPR_12
HKD3_k127_6109663_0	243231.GSU2782	0.0	1404.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJ8D@28221|Deltaproteobacteria,43S5E@69541|Desulfuromonadales	28221|Deltaproteobacteria	V	AcrB/AcrD/AcrF family	-	-	-	ko:K03296,ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
HKD3_k127_6109663_2	278957.ABEA03000197_gene423	6.374e-107	359.0	COG0845@1|root,COG0845@2|Bacteria,46U1B@74201|Verrucomicrobia,3K78A@414999|Opitutae	414999|Opitutae	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	HlyD_D23
HKD3_k127_6109663_10	1411123.JQNH01000001_gene124	5.832e-21	100.0	COG1309@1|root,COG1309@2|Bacteria,1RARJ@1224|Proteobacteria,2UAVR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	BetI-type transcriptional repressor, C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_6,TetR_N
HKD3_k127_6109663_6	497964.CfE428DRAFT_2500	3.636e-83	286.0	COG0037@1|root,COG0037@2|Bacteria,46T0B@74201|Verrucomicrobia	74201|Verrucomicrobia	D	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine	tilS	-	6.3.4.19	ko:K04075	-	-	R09597	RC02633,RC02634	ko00000,ko01000,ko03016	-	-	-	ATP_bind_3,TilS
HKD3_k127_6115985_13	1038867.AXAY01000014_gene5204	6.907e-62	227.0	COG1520@1|root,COG1520@2|Bacteria,1R95Z@1224|Proteobacteria,2UFTG@28211|Alphaproteobacteria,3K2JC@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_6115985_2	497964.CfE428DRAFT_2147	1.488e-145	470.0	COG0535@1|root,COG0535@2|Bacteria,46T4P@74201|Verrucomicrobia	74201|Verrucomicrobia	C	SMART Elongator protein 3 MiaB NifB	pqqE	-	-	ko:K06139	-	-	-	-	ko00000	-	-	-	Fer4_12,Fer4_14,Radical_SAM,SPASM
HKD3_k127_6115985_27	1303518.CCALI_00347	2.026e-14	78.0	COG0535@1|root,COG0535@2|Bacteria	2|Bacteria	I	radical SAM domain protein	pqqD	-	-	ko:K06138	-	-	-	-	ko00000	-	-	-	PqqD
HKD3_k127_6115985_3	497964.CfE428DRAFT_2149	4.514e-103	344.0	COG5424@1|root,COG5424@2|Bacteria,46TW4@74201|Verrucomicrobia	74201|Verrucomicrobia	H	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ	pqqC	-	1.3.3.11	ko:K06137	-	-	-	-	ko00000,ko01000	-	-	-	TENA_THI-4
HKD3_k127_6115985_10	497964.CfE428DRAFT_2150	1.546e-82	283.0	COG1235@1|root,COG1235@2|Bacteria,46VEV@74201|Verrucomicrobia	74201|Verrucomicrobia	S	May be involved in the transport of PQQ or its precursor to the periplasm	pqqB	-	-	ko:K06136	-	-	-	-	ko00000	-	-	-	Lactamase_B_2
HKD3_k127_6115985_21	937777.Deipe_1929	1.36e-35	151.0	COG2323@1|root,COG2323@2|Bacteria	2|Bacteria	K	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF421
HKD3_k127_6115985_19	497964.CfE428DRAFT_4168	7.772e-39	156.0	COG1729@1|root,COG1729@2|Bacteria	2|Bacteria	S	protein trimerization	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_21,TPR_6
HKD3_k127_6115985_16	497964.CfE428DRAFT_0564	4.574e-50	182.0	COG0103@1|root,COG0103@2|Bacteria,46SXI@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Belongs to the universal ribosomal protein uS9 family	rpsI	-	-	ko:K02996	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S9
HKD3_k127_6115985_11	497964.CfE428DRAFT_0563	5.563e-69	239.0	COG0102@1|root,COG0102@2|Bacteria,46VEU@74201|Verrucomicrobia	74201|Verrucomicrobia	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly	rplM	-	-	ko:K02871	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13
HKD3_k127_6115985_0	497964.CfE428DRAFT_2481	3.536e-242	758.0	COG0442@1|root,COG0442@2|Bacteria,46SE3@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro)	proS	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,ProRS-C_1,tRNA-synt_2b
HKD3_k127_6115985_28	525903.Taci_0792	3.175e-09	61.0	COG0695@1|root,COG0695@2|Bacteria,3TBJF@508458|Synergistetes	508458|Synergistetes	O	TIGRFAM Glutaredoxin-like protein, YruB-family	-	-	-	-	-	-	-	-	-	-	-	-	Glutaredoxin
HKD3_k127_6115985_5	497964.CfE428DRAFT_2970	9.003e-103	340.0	2F4YG@1|root,33XKC@2|Bacteria,46VC2@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_6115985_14	1123070.KB899254_gene1274	9.276e-62	221.0	COG1974@1|root,COG1974@2|Bacteria,46SU8@74201|Verrucomicrobia,2IU8D@203494|Verrucomicrobiae	203494|Verrucomicrobiae	KT	LexA DNA binding domain	-	-	-	-	-	-	-	-	-	-	-	-	LexA_DNA_bind,Peptidase_S24
HKD3_k127_6115985_24	452637.Oter_4055	2.443e-32	134.0	COG0468@1|root,COG0468@2|Bacteria,46ZHW@74201|Verrucomicrobia,3KA1M@414999|Opitutae	414999|Opitutae	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_6115985_26	497964.CfE428DRAFT_6154	2.374e-16	86.0	COG0389@1|root,COG0389@2|Bacteria,46SR8@74201|Verrucomicrobia	74201|Verrucomicrobia	L	impB/mucB/samB family	-	-	-	ko:K14161	-	-	-	-	ko00000,ko03400	-	-	-	IMS,IMS_C
HKD3_k127_6115985_23	497964.CfE428DRAFT_6673	5.08e-34	134.0	COG0724@1|root,COG0724@2|Bacteria,46VMU@74201|Verrucomicrobia	74201|Verrucomicrobia	S	PFAM RNP-1 like RNA-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	RRM_1
HKD3_k127_6115985_1	497964.CfE428DRAFT_0012	7.125e-146	473.0	COG0304@1|root,COG0304@2|Bacteria,46SKK@74201|Verrucomicrobia	74201|Verrucomicrobia	IQ	Beta-ketoacyl synthase, C-terminal domain	-	-	2.3.1.41	ko:K00647	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
HKD3_k127_6115985_8	497964.CfE428DRAFT_0013	3.406e-84	292.0	COG0304@1|root,COG0304@2|Bacteria,46Z8H@74201|Verrucomicrobia	74201|Verrucomicrobia	IQ	Beta-ketoacyl synthase, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	ketoacyl-synt
HKD3_k127_6115985_12	497964.CfE428DRAFT_2343	8.044e-65	229.0	COG1734@1|root,COG1734@2|Bacteria,46SVY@74201|Verrucomicrobia	74201|Verrucomicrobia	T	Prokaryotic dksA/traR C4-type zinc finger	dksA	-	-	-	-	-	-	-	-	-	-	-	zf-dskA_traR
HKD3_k127_6115985_25	1403819.BATR01000181_gene6224	1.245e-18	86.0	COG0267@1|root,COG0267@2|Bacteria,46T91@74201|Verrucomicrobia,2IUS7@203494|Verrucomicrobiae	203494|Verrucomicrobiae	J	Ribosomal protein L33	rpmG	-	-	ko:K02913	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L33
HKD3_k127_6115985_22	497964.CfE428DRAFT_2341	7.694e-35	134.0	COG0238@1|root,COG0238@2|Bacteria,46TBC@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Ribosomal protein S18	rpsR	-	-	ko:K02963	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S18
HKD3_k127_6115985_15	497964.CfE428DRAFT_2957	1.257e-50	181.0	COG2026@1|root,COG2026@2|Bacteria,46T5H@74201|Verrucomicrobia	74201|Verrucomicrobia	DJ	Addiction module toxin, RelE StbE family	-	-	-	-	-	-	-	-	-	-	-	-	ParE_toxin
HKD3_k127_6115985_6	497964.CfE428DRAFT_4525	3.246e-97	331.0	COG0787@1|root,COG0787@2|Bacteria,46SM1@74201|Verrucomicrobia	74201|Verrucomicrobia	E	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids	alr	-	5.1.1.1	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	-	R00401	RC00285	ko00000,ko00001,ko01000,ko01011	-	-	-	Ala_racemase_C,Ala_racemase_N
HKD3_k127_6115985_18	497964.CfE428DRAFT_3689	2.789e-43	165.0	COG1214@1|root,COG1214@2|Bacteria,46T3K@74201|Verrucomicrobia	74201|Verrucomicrobia	O	Glycoprotease family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M22
HKD3_k127_6115985_20	1403819.BATR01000002_gene22	4.054e-36	145.0	COG0802@1|root,COG0802@2|Bacteria,46T3C@74201|Verrucomicrobia,2IUJT@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Threonylcarbamoyl adenosine biosynthesis protein TsaE	-	-	-	ko:K06925	-	-	-	-	ko00000,ko03016	-	-	-	TsaE
HKD3_k127_6115985_9	497964.CfE428DRAFT_3691	8.636e-83	286.0	COG0611@1|root,COG0611@2|Bacteria,46SV7@74201|Verrucomicrobia	74201|Verrucomicrobia	H	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1	thiL	-	2.7.4.16	ko:K00946	ko00730,ko01100,map00730,map01100	M00127	R00617	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
HKD3_k127_6115985_29	570952.ATVH01000011_gene138	1.591e-06	59.0	COG1266@1|root,COG1266@2|Bacteria,1NF98@1224|Proteobacteria,2UHG6@28211|Alphaproteobacteria,2JUK0@204441|Rhodospirillales	204441|Rhodospirillales	S	CAAX protease self-immunity	-	-	-	-	-	-	-	-	-	-	-	-	Abi
HKD3_k127_6115985_4	497964.CfE428DRAFT_3693	6.253e-103	345.0	COG0616@1|root,COG0616@2|Bacteria,46SQ5@74201|Verrucomicrobia	74201|Verrucomicrobia	OU	signal peptide peptidase SppA, 36K type	sppA	-	-	ko:K04773	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S49
HKD3_k127_6115985_17	1242864.D187_003184	8.305e-44	169.0	COG0457@1|root,COG0457@2|Bacteria	1242864.D187_003184|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_6115985_7	686340.Metal_1658	6.677e-93	315.0	COG0457@1|root,COG0457@2|Bacteria,1R6ZR@1224|Proteobacteria,1RRKI@1236|Gammaproteobacteria,1XDM3@135618|Methylococcales	135618|Methylococcales	S	Domain of unknown function (DUF4071)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4071
HKD3_k127_6121673_0	452637.Oter_0043	2.482e-46	175.0	COG2197@1|root,COG2197@2|Bacteria,46V5Z@74201|Verrucomicrobia	74201|Verrucomicrobia	T	Two component transcriptional regulator, LuxR family	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HKD3_k127_6121673_2	1502852.FG94_02381	1.752e-06	61.0	COG3577@1|root,COG3577@2|Bacteria,1N45S@1224|Proteobacteria,2WCDW@28216|Betaproteobacteria,477DQ@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Aspartyl protease	-	-	-	-	-	-	-	-	-	-	-	-	Asp_protease_2
HKD3_k127_6121673_1	240016.ABIZ01000001_gene5815	2.819e-42	159.0	COG0327@1|root,COG0327@2|Bacteria,46U7Z@74201|Verrucomicrobia,2IU4W@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	NIF3 (NGG1p interacting factor 3)	-	-	-	-	-	-	-	-	-	-	-	-	NIF3
HKD3_k127_6123606_9	182217.HCW_06835	0.0007833	48.0	COG2887@1|root,COG2887@2|Bacteria,1QUIU@1224|Proteobacteria,42M7I@68525|delta/epsilon subdivisions,2YMX0@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	L	COG3893 inactivated superfamily I helicase	addB	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_1
HKD3_k127_6123606_6	1027273.GZ77_01420	1.687e-36	142.0	2DNW1@1|root,32ZFG@2|Bacteria,1NBSM@1224|Proteobacteria,1S8G5@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_6123606_8	272624.lpg1742	0.0007057	48.0	2E9J1@1|root,333RY@2|Bacteria,1NIX0@1224|Proteobacteria,1SGM0@1236|Gammaproteobacteria,1JFBK@118969|Legionellales	118969|Legionellales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_6123606_5	497964.CfE428DRAFT_0792	5.772e-40	154.0	COG2839@1|root,COG2839@2|Bacteria,46WEX@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Protein of unknown function (DUF456)	-	-	-	ko:K09793	-	-	-	-	ko00000	-	-	-	DUF456
HKD3_k127_6123606_3	1396141.BATP01000028_gene2352	7.196e-62	217.0	COG1225@1|root,COG1225@2|Bacteria,46V63@74201|Verrucomicrobia,2IWQI@203494|Verrucomicrobiae	203494|Verrucomicrobiae	O	Redoxin	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
HKD3_k127_6123606_0	497964.CfE428DRAFT_1607	0.0	1394.0	COG1048@1|root,COG1048@2|Bacteria,46SFS@74201|Verrucomicrobia	74201|Verrucomicrobia	C	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate	acnA	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
HKD3_k127_6123606_2	1379698.RBG1_1C00001G0607	1.264e-108	387.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,2NQNE@2323|unclassified Bacteria	2|Bacteria	T	Serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase,TPR_2,TPR_8
HKD3_k127_6123606_4	234267.Acid_7677	6.069e-57	206.0	COG1595@1|root,COG1595@2|Bacteria,3Y7UW@57723|Acidobacteria	57723|Acidobacteria	K	ECF sigma factor	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_ECF
HKD3_k127_6123606_1	365528.KB891102_gene4557	4.757e-110	372.0	COG0671@1|root,COG0671@2|Bacteria,2I8WW@201174|Actinobacteria	201174|Actinobacteria	I	COG3209 Rhs family protein	-	-	-	-	-	-	-	-	-	-	-	-	PAP2
HKD3_k127_6125005_4	1127134.NOCYR_2830	7.387e-08	59.0	COG3631@1|root,COG3631@2|Bacteria,2IMNM@201174|Actinobacteria,4FYGS@85025|Nocardiaceae	201174|Actinobacteria	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440
HKD3_k127_6125005_0	323097.Nham_4370	0.0	1516.0	COG0637@1|root,COG1554@1|root,COG0637@2|Bacteria,COG1554@2|Bacteria,1MWJE@1224|Proteobacteria,2U1CG@28211|Alphaproteobacteria,3JWWP@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Glycosyl hydrolase family 65, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_65C,Glyco_hydro_65N,Glyco_hydro_65m,HAD_2
HKD3_k127_6125005_1	497964.CfE428DRAFT_1833	7.019e-156	511.0	COG1075@1|root,COG1075@2|Bacteria,46TIU@74201|Verrucomicrobia	74201|Verrucomicrobia	S	acetyltransferases and hydrolases with the alpha beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
HKD3_k127_6125005_2	1496688.ER33_02795	1.314e-138	451.0	COG2326@1|root,COG2326@2|Bacteria,1G159@1117|Cyanobacteria,22TKN@167375|Cyanobium	1117|Cyanobacteria	S	Polyphosphate kinase 2 (PPK2)	-	-	-	-	-	-	-	-	-	-	-	-	PPK2
HKD3_k127_6125005_3	639030.JHVA01000001_gene1491	1.051e-38	148.0	COG3247@1|root,COG3247@2|Bacteria,3Y5AN@57723|Acidobacteria,2JJYZ@204432|Acidobacteriia	204432|Acidobacteriia	S	Short repeat of unknown function (DUF308)	-	-	-	-	-	-	-	-	-	-	-	-	DUF308
HKD3_k127_6125099_0	1192034.CAP_6066	6.222e-76	261.0	COG0604@1|root,COG0604@2|Bacteria,1MX8A@1224|Proteobacteria	1224|Proteobacteria	C	COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases	-	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N_2
HKD3_k127_6125099_3	383372.Rcas_3553	2.979e-24	105.0	COG1917@1|root,COG1917@2|Bacteria,2G9GF@200795|Chloroflexi,377M6@32061|Chloroflexia	32061|Chloroflexia	S	PFAM Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HKD3_k127_6125099_2	485918.Cpin_1703	5.878e-31	134.0	2B9NZ@1|root,3231D@2|Bacteria,4NR0T@976|Bacteroidetes,1IUNH@117747|Sphingobacteriia	976|Bacteroidetes	S	Protein of unknown function (DUF1579)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1579
HKD3_k127_6125099_1	234267.Acid_0571	1.618e-33	130.0	COG0346@1|root,COG0346@2|Bacteria,3Y85T@57723|Acidobacteria	57723|Acidobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HKD3_k127_616170_0	1122604.JONR01000031_gene1279	6.064e-109	373.0	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1T5SE@1236|Gammaproteobacteria,1XDE6@135614|Xanthomonadales	135614|Xanthomonadales	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_19
HKD3_k127_616170_4	247490.KSU1_D0807	1.816e-24	115.0	2BRMQ@1|root,32KM4@2|Bacteria,2J4AR@203682|Planctomycetes	247490.KSU1_D0807|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_616170_7	266940.Krad_3513	0.0003927	49.0	COG0477@1|root,COG4932@1|root,COG0477@2|Bacteria,COG4932@2|Bacteria,2GJ09@201174|Actinobacteria	201174|Actinobacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,MFS_1
HKD3_k127_616170_5	1122604.JONR01000013_gene3265	8.44e-21	98.0	2EJV8@1|root,33DJW@2|Bacteria,1NIK0@1224|Proteobacteria,1SGMC@1236|Gammaproteobacteria,1XBNS@135614|Xanthomonadales	135614|Xanthomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_616170_2	452637.Oter_0582	4.143e-32	139.0	COG1566@1|root,COG1566@2|Bacteria,46W2H@74201|Verrucomicrobia	74201|Verrucomicrobia	V	Protein of unknown function (DUF3667)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3667
HKD3_k127_616170_1	13035.Dacsa_2593	2.836e-64	238.0	COG3210@1|root,COG3210@2|Bacteria,1GPZ7@1117|Cyanobacteria	2|Bacteria	U	Parallel beta-helix repeats	mshQ	-	-	ko:K12287	-	-	-	-	ko00000,ko02044	-	-	-	Laminin_G_3
HKD3_k127_616170_6	1496688.ER33_10370	6.674e-08	57.0	COG0454@1|root,COG0454@2|Bacteria	2|Bacteria	K	-acetyltransferase	-	-	2.3.1.82	ko:K03830,ko:K18816	-	-	-	-	br01600,ko00000,ko01000,ko01504	-	-	-	Acetyltransf_1,Acetyltransf_10
HKD3_k127_616170_3	1038859.AXAU01000012_gene4234	3.655e-31	131.0	2AKNV@1|root,31BFG@2|Bacteria,1NZ2P@1224|Proteobacteria,2USTH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF3237
HKD3_k127_6199299_1	452637.Oter_0618	1.241e-87	294.0	COG3591@1|root,COG3591@2|Bacteria,46UUQ@74201|Verrucomicrobia	74201|Verrucomicrobia	E	Peptidase S46	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S46
HKD3_k127_6199299_4	1318628.MARLIPOL_01155	4.684e-64	229.0	COG0500@1|root,COG2226@2|Bacteria,1QYC9@1224|Proteobacteria,1S4V4@1236|Gammaproteobacteria,46900@72275|Alteromonadaceae	1236|Gammaproteobacteria	Q	Sulfotransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_1,Sulfotransfer_3
HKD3_k127_6199299_7	113395.AXAI01000002_gene5313	2.344e-36	147.0	2EFWC@1|root,339NM@2|Bacteria,1NG7T@1224|Proteobacteria,2UY62@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_6199299_9	1101190.ARWB01000001_gene1037	3.183e-16	90.0	2DRBV@1|root,33B5H@2|Bacteria,1NFAH@1224|Proteobacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_6199299_6	1122604.JONR01000031_gene1282	1.184e-55	202.0	COG4291@1|root,COG4291@2|Bacteria,1RIAS@1224|Proteobacteria,1SP50@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_6199299_0	497964.CfE428DRAFT_4568	6.745e-170	544.0	28MGX@1|root,2ZATZ@2|Bacteria,46TJV@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_6199299_2	497964.CfE428DRAFT_4571	1.18e-78	267.0	COG0632@1|root,COG0632@2|Bacteria,46SZF@74201|Verrucomicrobia	74201|Verrucomicrobia	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB	ruvA	-	3.6.4.12	ko:K03550	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HHH_5,RuvA_C,RuvA_N
HKD3_k127_6199299_3	1396418.BATQ01000147_gene3590	9.381e-67	247.0	COG1807@1|root,COG1807@2|Bacteria,46SJQ@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HKD3_k127_6199299_10	666686.B1NLA3E_17995	4.249e-11	72.0	COG0671@1|root,COG0671@2|Bacteria,1V33Y@1239|Firmicutes,4HGAT@91061|Bacilli,1ZFPM@1386|Bacillus	91061|Bacilli	I	COG0671 Membrane-associated phospholipid phosphatase	pgpB1	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2
HKD3_k127_6199299_5	1007103.AFHW01000029_gene1633	7.724e-58	212.0	COG2267@1|root,COG2267@2|Bacteria,1V0IY@1239|Firmicutes,4HBP3@91061|Bacilli,26T7K@186822|Paenibacillaceae	91061|Bacilli	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Hydrolase_4
HKD3_k127_6203129_3	443143.GM18_1307	1.359e-10	67.0	COG0226@1|root,COG0226@2|Bacteria,1MUAZ@1224|Proteobacteria,42NM3@68525|delta/epsilon subdivisions,2WMH9@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	Part of the ABC transporter complex PstSACB involved in phosphate import	pstS	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
HKD3_k127_6203129_0	497964.CfE428DRAFT_3934	5.571e-93	319.0	COG5002@1|root,COG5002@2|Bacteria,46SSA@74201|Verrucomicrobia	74201|Verrucomicrobia	T	PFAM ATP-binding region ATPase domain protein	-	-	2.7.13.3	ko:K07636	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS,PAS_4,PAS_9
HKD3_k127_6203129_1	497964.CfE428DRAFT_3933	2.788e-87	295.0	COG0745@1|root,COG0745@2|Bacteria,46SS3@74201|Verrucomicrobia	74201|Verrucomicrobia	T	Two component transcriptional regulator, winged helix family	-	-	-	ko:K07657	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
HKD3_k127_6203129_2	452637.Oter_2544	2.198e-42	170.0	COG2067@1|root,COG2067@2|Bacteria	2|Bacteria	I	long-chain fatty acid transporting porin activity	-	-	-	-	-	-	-	-	-	-	-	-	Porin_5,Porin_O_P
HKD3_k127_620996_1	522306.CAP2UW1_0135	1.223e-46	171.0	2BYGX@1|root,32U2R@2|Bacteria,1RCK4@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_620996_0	1123393.KB891326_gene93	1.759e-140	456.0	COG0282@1|root,COG0282@2|Bacteria,1MW61@1224|Proteobacteria,2VHRC@28216|Betaproteobacteria,1KRJW@119069|Hydrogenophilales	119069|Hydrogenophilales	C	Acetokinase family	-	-	2.7.2.1	ko:K00925	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00315,R01353	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetate_kinase
HKD3_k127_620996_2	661478.OP10G_1466	1.569e-43	161.0	COG0546@1|root,COG0546@2|Bacteria	2|Bacteria	S	glycolate biosynthetic process	-	-	3.1.3.18	ko:K01091,ko:K05967,ko:K07025	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2,NT5C
HKD3_k127_6214143_2	497964.CfE428DRAFT_2289	2.353e-154	496.0	COG0593@1|root,COG0593@2|Bacteria,46S6H@74201|Verrucomicrobia	74201|Verrucomicrobia	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids	dnaA	-	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA,Bac_DnaA_C,DnaA_N
HKD3_k127_6214143_3	945713.IALB_1286	6.356e-153	491.0	COG2170@1|root,COG2170@2|Bacteria	2|Bacteria	S	glutamate-cysteine ligase activity	ybdK	GO:0003674,GO:0003824,GO:0016874,GO:0016879	-	ko:K06048	-	-	-	-	ko00000,ko01000	-	-	-	GCS2
HKD3_k127_6214143_4	945713.IALB_1287	1.137e-148	477.0	COG0189@1|root,COG0189@2|Bacteria	2|Bacteria	HJ	Glutathione synthase Ribosomal protein S6 modification enzyme (Glutaminyl transferase)	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_6214143_15	497964.CfE428DRAFT_6146	3.385e-56	199.0	COG0346@1|root,COG0346@2|Bacteria,46SUF@74201|Verrucomicrobia	74201|Verrucomicrobia	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	4.4.1.5	ko:K01759	ko00620,map00620	-	R02530	RC00004,RC00740	ko00000,ko00001,ko01000	-	-	-	Glyoxalase,Glyoxalase_4
HKD3_k127_6214143_10	497964.CfE428DRAFT_3335	2.33e-84	292.0	COG1686@1|root,COG1686@2|Bacteria	2|Bacteria	M	Belongs to the peptidase S11 family	-	-	3.4.16.4	ko:K07258	ko00550,ko01100,map00550,map01100	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	Peptidase_S11
HKD3_k127_6214143_8	497964.CfE428DRAFT_3566	2.914e-99	333.0	COG2220@1|root,COG2220@2|Bacteria,46UV4@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
HKD3_k127_6214143_19	1128421.JAGA01000003_gene3187	3.572e-25	118.0	COG0589@1|root,COG0589@2|Bacteria	2|Bacteria	T	AMP binding	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD3_k127_6214143_13	868595.Desca_0806	2.891e-69	245.0	COG0730@1|root,COG0730@2|Bacteria,1UI7C@1239|Firmicutes,24DK7@186801|Clostridia	186801|Clostridia	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
HKD3_k127_6214143_18	481448.Minf_1147	1.086e-38	145.0	COG1141@1|root,COG1141@2|Bacteria,46T2D@74201|Verrucomicrobia,37GX8@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	C	4Fe-4S single cluster domain of Ferredoxin I	-	-	-	ko:K05337	-	-	-	-	ko00000	-	-	-	Fer4_13
HKD3_k127_6214143_12	497964.CfE428DRAFT_2565	5.13e-77	267.0	COG0351@1|root,COG0351@2|Bacteria,46SVN@74201|Verrucomicrobia	74201|Verrucomicrobia	H	Phosphomethylpyrimidine kinase	-	-	2.7.1.49,2.7.4.7	ko:K00941	ko00730,ko01100,map00730,map01100	M00127	R03471,R04509	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Phos_pyr_kin
HKD3_k127_6214143_9	1123070.KB899254_gene1231	1.517e-85	289.0	COG0571@1|root,COG0571@2|Bacteria,46T3X@74201|Verrucomicrobia,2IU7S@203494|Verrucomicrobiae	203494|Verrucomicrobiae	K	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism	rnc	-	3.1.26.3	ko:K03685	ko03008,ko05205,map03008,map05205	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019,ko03036	-	-	-	Ribonucleas_3_3,dsrm
HKD3_k127_6214143_11	497964.CfE428DRAFT_2563	1.383e-79	279.0	COG0793@1|root,COG0793@2|Bacteria,46VYN@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Peptidase family S41	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S41
HKD3_k127_6214143_6	555088.DealDRAFT_1872	1.821e-142	464.0	COG0151@1|root,COG0151@2|Bacteria,1UHN9@1239|Firmicutes,25E76@186801|Clostridia,42JIT@68298|Syntrophomonadaceae	186801|Clostridia	F	Belongs to the GARS family	purD	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	GARS_A,GARS_C,GARS_N
HKD3_k127_6214143_7	1173026.Glo7428_0087	4.415e-118	389.0	COG0265@1|root,COG0265@2|Bacteria,1G3M4@1117|Cyanobacteria	1117|Cyanobacteria	O	Domain present in PSD-95, Dlg, and ZO-1/2.	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
HKD3_k127_6214143_17	1173026.Glo7428_0086	2.216e-42	160.0	COG1733@1|root,COG1733@2|Bacteria,1G84R@1117|Cyanobacteria	1117|Cyanobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HxlR
HKD3_k127_6214143_26	91464.S7335_4522	0.0007563	44.0	COG4424@1|root,COG4424@2|Bacteria	2|Bacteria	S	carbohydrate metabolic process	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_1,Sulfotransfer_3
HKD3_k127_6214143_20	391589.RGAI101_3935	7.653e-25	116.0	COG4424@1|root,COG4424@2|Bacteria,1N77D@1224|Proteobacteria,2TW4Z@28211|Alphaproteobacteria,2P3TN@2433|Roseobacter	28211|Alphaproteobacteria	H	Sulfotransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_3
HKD3_k127_6214143_16	1267534.KB906754_gene3574	1.542e-43	164.0	COG2905@1|root,COG2905@2|Bacteria,3Y5NG@57723|Acidobacteria	57723|Acidobacteria	T	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
HKD3_k127_6214143_0	497964.CfE428DRAFT_2609	8.116e-188	596.0	COG0044@1|root,COG0044@2|Bacteria,46S78@74201|Verrucomicrobia	74201|Verrucomicrobia	F	Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily	pyrC	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
HKD3_k127_6214143_5	497964.CfE428DRAFT_2607	1.491e-147	473.0	COG0540@1|root,COG0540@2|Bacteria,46S9E@74201|Verrucomicrobia	74201|Verrucomicrobia	F	Belongs to the ATCase OTCase family	pyrB	-	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
HKD3_k127_6214143_14	497964.CfE428DRAFT_2606	6.621e-59	209.0	COG2065@1|root,COG2065@2|Bacteria,46VY6@74201|Verrucomicrobia	74201|Verrucomicrobia	F	Phosphoribosyl transferase domain	pyrR	-	2.4.2.9	ko:K02825	ko00240,ko01100,map00240,map01100	-	R00966	RC00063	ko00000,ko00001,ko01000,ko03000	-	-	-	Pribosyltran
HKD3_k127_6214143_22	497964.CfE428DRAFT_2605	3.252e-22	98.0	2E99J@1|root,333HQ@2|Bacteria,46T77@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4032
HKD3_k127_6214143_1	497964.CfE428DRAFT_2604	3.448e-156	499.0	COG0489@1|root,COG0489@2|Bacteria,46SAV@74201|Verrucomicrobia	74201|Verrucomicrobia	D	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP	mrp	-	-	ko:K03593	-	-	-	-	ko00000,ko03029,ko03036	-	-	-	FeS_assembly_P,ParA
HKD3_k127_6214143_25	376686.Fjoh_2329	5.352e-07	53.0	COG2373@1|root,COG2373@2|Bacteria,4NSQZ@976|Bacteroidetes,1I45X@117743|Flavobacteriia,2NW7U@237|Flavobacterium	976|Bacteroidetes	S	Cytochrome oxidase complex assembly protein 1	-	-	-	-	-	-	-	-	-	-	-	-	Coa1
HKD3_k127_6214143_23	292564.Cyagr_1513	3.194e-20	96.0	COG2373@1|root,COG2373@2|Bacteria	2|Bacteria	U	Large extracellular alpha-helical protein	-	-	-	-	-	-	-	-	-	-	-	-	Coa1,Rib
HKD3_k127_6214143_21	497964.CfE428DRAFT_6325	9.63e-25	106.0	COG0438@1|root,COG0438@2|Bacteria,46TH7@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
HKD3_k127_6232828_6	1340493.JNIF01000003_gene4412	2.268e-102	351.0	COG1167@1|root,COG1167@2|Bacteria,3Y3WK@57723|Acidobacteria	57723|Acidobacteria	K	helix_turn_helix gluconate operon transcriptional repressor	-	-	-	ko:K00375	-	-	-	-	ko00000,ko03000	-	-	-	Aminotran_1_2,GntR
HKD3_k127_6232828_7	1267535.KB906767_gene1566	4.196e-100	331.0	COG0603@1|root,COG0603@2|Bacteria,3Y3RP@57723|Acidobacteria,2JHPC@204432|Acidobacteriia	204432|Acidobacteriia	F	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))	queC	-	6.3.4.20	ko:K06920	ko00790,ko01100,map00790,map01100	-	R09978	RC00959	ko00000,ko00001,ko01000,ko03016	-	-	-	QueC
HKD3_k127_6232828_12	1403819.BATR01000181_gene6215	1.39e-47	176.0	COG0780@1|root,COG0780@2|Bacteria,46SYQ@74201|Verrucomicrobia,2IUI4@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	QueF-like protein	queF	-	1.7.1.13	ko:K09457	ko00790,ko01100,map00790,map01100	-	R07605	RC01875	ko00000,ko00001,ko01000,ko03016	-	-	-	QueF
HKD3_k127_6232828_17	663610.JQKO01000017_gene1661	0.0002274	44.0	COG3542@1|root,COG3542@2|Bacteria,1RAD7@1224|Proteobacteria,2U6RX@28211|Alphaproteobacteria,3NCDQ@45404|Beijerinckiaceae	28211|Alphaproteobacteria	S	Cupin superfamily (DUF985)	-	-	-	ko:K09705	-	-	-	-	ko00000	-	-	-	Cupin_5
HKD3_k127_6232828_11	1380394.JADL01000004_gene5750	1.794e-65	226.0	COG3542@1|root,COG3542@2|Bacteria,1RAD7@1224|Proteobacteria,2U6RX@28211|Alphaproteobacteria,2JY7V@204441|Rhodospirillales	204441|Rhodospirillales	S	Cupin superfamily (DUF985)	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_5
HKD3_k127_6232828_4	395961.Cyan7425_3554	1.939e-119	399.0	COG2271@1|root,COG2271@2|Bacteria	2|Bacteria	G	transmembrane transporter activity	-	-	-	ko:K13021	-	-	-	-	ko00000,ko02000	2.A.1.14.3	-	-	MFS_1
HKD3_k127_6232828_10	497964.CfE428DRAFT_6254	1.886e-67	237.0	COG2071@1|root,COG2071@2|Bacteria	2|Bacteria	S	gamma-glutamyl-gamma-aminobutyrate hydrolase activity	-	-	4.1.3.27	ko:K01658,ko:K07010	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	Peptidase_C26
HKD3_k127_6232828_8	497964.CfE428DRAFT_0884	2.86e-75	263.0	COG2367@1|root,COG2367@2|Bacteria	2|Bacteria	V	Beta-lactamase	-	-	3.4.11.2,3.5.2.6	ko:K01256,ko:K17836	ko00311,ko00480,ko01100,ko01130,ko01501,map00311,map00480,map01100,map01130,map01501	M00627,M00628	R00899,R04951,R06363	RC00096,RC00141,RC01499	ko00000,ko00001,ko00002,ko01000,ko01002,ko01504	-	-	-	Beta-lactamase,Beta-lactamase2
HKD3_k127_6232828_9	497964.CfE428DRAFT_0885	3.315e-75	258.0	2F2ZI@1|root,33VUW@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_6232828_5	497964.CfE428DRAFT_0886	7.946e-119	395.0	2EYW5@1|root,33S36@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_6232828_1	452637.Oter_4531	4.713e-205	655.0	COG4805@1|root,COG4805@2|Bacteria,46T5D@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Bacterial protein of unknown function (DUF885)	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
HKD3_k127_6232828_3	452637.Oter_1524	5.055e-153	497.0	COG3104@1|root,COG3104@2|Bacteria	2|Bacteria	E	oligopeptide transport	-	-	-	ko:K03305	-	-	-	-	ko00000	2.A.17	-	-	PTR2
HKD3_k127_6232828_0	497964.CfE428DRAFT_2154	1.012e-255	816.0	COG1674@1|root,COG1674@2|Bacteria,46SCV@74201|Verrucomicrobia	74201|Verrucomicrobia	D	PFAM cell divisionFtsK SpoIIIE	-	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
HKD3_k127_6232828_15	243231.GSU1115	4.249e-08	64.0	COG1426@1|root,COG1426@2|Bacteria,1NN27@1224|Proteobacteria,42V2R@68525|delta/epsilon subdivisions,2WQP6@28221|Deltaproteobacteria,43V92@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF4115)	-	-	-	ko:K15539	-	-	-	-	ko00000	-	-	-	DUF4115,HTH_25
HKD3_k127_6232828_2	497964.CfE428DRAFT_2152	1.908e-204	648.0	COG0621@1|root,COG0621@2|Bacteria,46S5U@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12	rimO	-	2.8.4.4	ko:K14441	-	-	R10652	RC00003,RC03217	ko00000,ko01000,ko03009	-	-	-	Radical_SAM,TRAM,UPF0004
HKD3_k127_6232828_13	497964.CfE428DRAFT_2471	1.081e-33	138.0	COG3118@1|root,COG3118@2|Bacteria,46VWK@74201|Verrucomicrobia	74201|Verrucomicrobia	O	Belongs to the thioredoxin family	-	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
HKD3_k127_6242054_1	1379270.AUXF01000006_gene150	1.553e-45	169.0	2DEWU@1|root,2ZPJP@2|Bacteria,1ZUFA@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_6242054_0	467200.ACFA01000077_gene6294	1.701e-69	241.0	COG1233@1|root,COG1233@2|Bacteria,2GMUC@201174|Actinobacteria	201174|Actinobacteria	Q	oxidoreductase	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	-	-	-	-	-	-	-	-	-	Amino_oxidase,DAO,NAD_binding_8
HKD3_k127_6273518_13	452637.Oter_1803	7.125e-20	91.0	COG4263@1|root,COG4263@2|Bacteria,46YT5@74201|Verrucomicrobia,3K7SZ@414999|Opitutae	414999|Opitutae	C	Cupredoxin-like domain	-	-	1.7.2.4	ko:K00376	ko00910,ko01120,map00910,map01120	M00529	R02804	RC02861	ko00000,ko00001,ko00002,ko01000	-	-	-	Cupredoxin_1
HKD3_k127_6273518_12	452637.Oter_1802	2.621e-32	134.0	COG3241@1|root,COG3241@2|Bacteria,46W0N@74201|Verrucomicrobia,3K84F@414999|Opitutae	414999|Opitutae	C	Copper binding proteins, plastocyanin/azurin family	-	-	-	-	-	-	-	-	-	-	-	-	Copper-bind
HKD3_k127_6273518_9	278957.ABEA03000176_gene2841	3.324e-62	225.0	COG1999@1|root,COG1999@2|Bacteria,46W2T@74201|Verrucomicrobia,3K80B@414999|Opitutae	414999|Opitutae	S	Copper binding periplasmic protein CusF	-	-	-	ko:K07152	-	-	-	-	ko00000,ko03029	-	-	-	CusF_Ec,SCO1-SenC
HKD3_k127_6273518_3	945713.IALB_1286	3.42e-147	475.0	COG2170@1|root,COG2170@2|Bacteria	2|Bacteria	S	glutamate-cysteine ligase activity	ybdK	GO:0003674,GO:0003824,GO:0016874,GO:0016879	-	ko:K06048	-	-	-	-	ko00000,ko01000	-	-	-	GCS2
HKD3_k127_6273518_6	1173024.KI912153_gene217	5.729e-117	383.0	COG0167@1|root,COG0167@2|Bacteria,1G2B6@1117|Cyanobacteria,1JKMZ@1189|Stigonemataceae	1117|Cyanobacteria	F	Dihydroorotate dehydrogenase	-	-	1.3.98.1	ko:K00226	ko00240,ko01100,map00240,map01100	M00051	R01867	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
HKD3_k127_6273518_7	635013.TherJR_0948	1.983e-113	387.0	COG2132@1|root,COG2132@2|Bacteria,1TQSU@1239|Firmicutes,24CJP@186801|Clostridia,260KE@186807|Peptococcaceae	186801|Clostridia	Q	Multicopper oxidase	-	-	1.16.3.3	ko:K06324	-	-	-	-	ko00000,ko01000	-	-	-	Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3
HKD3_k127_6273518_4	234267.Acid_3925	4.444e-127	414.0	COG2309@1|root,COG2309@2|Bacteria,3Y46T@57723|Acidobacteria	57723|Acidobacteria	E	aminopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M29
HKD3_k127_6273518_5	945713.IALB_1284	7.112e-119	396.0	COG2308@1|root,COG2308@2|Bacteria	2|Bacteria	S	glutamate-cysteine ligase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_6273518_10	1226994.AMZB01000121_gene3419	1.732e-57	207.0	COG1247@1|root,COG1247@2|Bacteria,1RDHN@1224|Proteobacteria,1SEM6@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Acetyltransferase (GNAT) domain	-	-	2.3.1.183	ko:K03823	ko00440,ko01130,map00440,map01130	-	R08871,R08938	RC00004,RC00064	ko00000,ko00001,ko01000	-	-	-	Acetyltransf_4
HKD3_k127_6273518_8	497964.CfE428DRAFT_3345	5.907e-70	239.0	COG0822@1|root,COG0822@2|Bacteria,46SZ3@74201|Verrucomicrobia	74201|Verrucomicrobia	C	TIGRFAM SUF system FeS assembly protein, NifU family	iscU	-	-	ko:K04488	-	-	-	-	ko00000	-	-	-	NifU_N
HKD3_k127_6273518_0	497964.CfE428DRAFT_3346	1.137e-209	659.0	COG0520@1|root,COG0520@2|Bacteria,46S58@74201|Verrucomicrobia	74201|Verrucomicrobia	E	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine	-	-	2.8.1.7,4.4.1.16	ko:K11717	ko00450,ko01100,map00450,map01100	-	R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000	-	-	-	Aminotran_5
HKD3_k127_6273518_1	1313301.AUGC01000008_gene386	2.122e-179	569.0	COG0156@1|root,COG0156@2|Bacteria,4NFBU@976|Bacteroidetes	976|Bacteroidetes	E	Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA	kbl	-	2.3.1.29	ko:K00639	ko00260,map00260	-	R00371	RC00004,RC00394	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
HKD3_k127_6273518_11	497964.CfE428DRAFT_5957	3.123e-48	182.0	COG3584@1|root,COG3584@2|Bacteria,46VUB@74201|Verrucomicrobia	74201|Verrucomicrobia	S	3D domain	-	-	-	-	-	-	-	-	-	-	-	-	3D
HKD3_k127_6273518_15	1501391.LG35_06475	2.141e-08	66.0	COG4122@1|root,COG4122@2|Bacteria,4NH42@976|Bacteroidetes,2FM5S@200643|Bacteroidia,22UDA@171550|Rikenellaceae	976|Bacteroidetes	S	O-methyltransferase	mdmC	-	2.1.1.104	ko:K00588	ko00360,ko00940,ko00941,ko00945,ko01100,ko01110,map00360,map00940,map00941,map00945,map01100,map01110	M00039,M00350	R01942,R06578	RC00003,RC00392	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_3
HKD3_k127_6273518_2	706587.Desti_4248	1.555e-173	549.0	COG1063@1|root,COG1063@2|Bacteria,1MV9A@1224|Proteobacteria,42PCA@68525|delta/epsilon subdivisions,2WM39@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Catalyzes the NAD( )-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate	tdh	-	1.1.1.103	ko:K00060	ko00260,map00260	-	R01465	RC00525	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
HKD3_k127_6273518_14	1137281.D778_01482	1.071e-13	81.0	COG3209@1|root,COG5295@1|root,COG3209@2|Bacteria,COG5295@2|Bacteria,4NJTK@976|Bacteroidetes,1HZNB@117743|Flavobacteriia	976|Bacteroidetes	UW	surface antigen	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S74
HKD3_k127_6288657_16	387093.SUN_0960	1.806e-27	114.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,42MUK@68525|delta/epsilon subdivisions,2YNN0@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	P	Belongs to the ABC transporter superfamily	potA	-	3.6.3.30,3.6.3.31	ko:K02010,ko:K02052,ko:K11072	ko02010,ko02024,map02010,map02024	M00190,M00193,M00299	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.10,3.A.1.11,3.A.1.11.1	-	-	ABC_tran,TOBE_2
HKD3_k127_6288657_8	1267535.KB906767_gene2004	2.316e-94	320.0	COG3391@1|root,COG3391@2|Bacteria,3Y4CD@57723|Acidobacteria,2JJ1Y@204432|Acidobacteriia	204432|Acidobacteriia	S	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_6288657_9	1267535.KB906767_gene1775	6.577e-73	259.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF5050,Stig1,ZU5
HKD3_k127_6288657_10	1303518.CCALI_00582	5.028e-48	181.0	2905E@1|root,2ZMVA@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Phenol_MetA_deg
HKD3_k127_6288657_6	1304865.JAGF01000001_gene3537	3.48e-103	347.0	COG0053@1|root,COG0053@2|Bacteria,2GJ8Q@201174|Actinobacteria	201174|Actinobacteria	P	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,ZT_dimer
HKD3_k127_6288657_5	700598.Niako_6986	8.859e-104	351.0	COG0477@1|root,COG2814@2|Bacteria	2|Bacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_1_like,Sugar_tr
HKD3_k127_6288657_15	497964.CfE428DRAFT_3022	1.047e-27	115.0	COG2363@1|root,COG2363@2|Bacteria,46T86@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Protein of unknown function (DUF423)	-	-	-	-	-	-	-	-	-	-	-	-	DUF423
HKD3_k127_6288657_2	497964.CfE428DRAFT_2501	9.065e-126	419.0	COG0664@1|root,COG0668@1|root,COG0664@2|Bacteria,COG0668@2|Bacteria	2|Bacteria	M	transmembrane transport	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel,cNMP_binding
HKD3_k127_6288657_17	497964.CfE428DRAFT_3965	5.882e-26	114.0	COG5002@1|root,COG5002@2|Bacteria	2|Bacteria	T	protein histidine kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_4,PAS_9,Response_reg
HKD3_k127_6288657_14	1403819.BATR01000191_gene6519	3.975e-34	135.0	COG5642@1|root,COG5642@2|Bacteria,46XIK@74201|Verrucomicrobia,2IW0M@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Protein of unknown function (DUF2384)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2384
HKD3_k127_6288657_12	1403819.BATR01000191_gene6518	5.325e-37	145.0	COG5654@1|root,COG5654@2|Bacteria,46XMG@74201|Verrucomicrobia,2IW6Y@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	RES	-	-	-	-	-	-	-	-	-	-	-	-	RES
HKD3_k127_6288657_18	385682.AFSL01000025_gene2079	7.002e-23	107.0	COG1266@1|root,COG1266@2|Bacteria,4NGBZ@976|Bacteroidetes	976|Bacteroidetes	S	CAAX protease self-immunity	-	-	-	-	-	-	-	-	-	-	-	-	Abi
HKD3_k127_6288657_3	382464.ABSI01000020_gene247	1.002e-119	396.0	COG0438@1|root,COG0438@2|Bacteria,46TCW@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
HKD3_k127_6288657_7	452637.Oter_2608	2.108e-94	315.0	2F12M@1|root,33U44@2|Bacteria,46V6U@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_6288657_1	382464.ABSI01000020_gene244	3.28e-205	654.0	COG0591@1|root,COG0591@2|Bacteria,46UFJ@74201|Verrucomicrobia,2IVV1@203494|Verrucomicrobiae	203494|Verrucomicrobiae	E	Sodium:solute symporter family	-	-	-	-	-	-	-	-	-	-	-	-	SSF
HKD3_k127_6288657_0	926549.KI421517_gene2980	4.326e-270	857.0	COG2120@1|root,COG2120@2|Bacteria,4NE9K@976|Bacteroidetes,47KXK@768503|Cytophagia	976|Bacteroidetes	G	PFAM GlcNAc-PI de-N-acetylase	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
HKD3_k127_6288657_4	234267.Acid_4617	8.453e-110	366.0	COG0457@1|root,COG0457@2|Bacteria,3Y4T0@57723|Acidobacteria	57723|Acidobacteria	S	Protein of unknown function (DUF2911)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2911
HKD3_k127_6288657_13	1122604.JONR01000008_gene2129	1.399e-34	141.0	COG1266@1|root,COG1266@2|Bacteria,1NXKQ@1224|Proteobacteria	1224|Proteobacteria	S	CAAX protease self-immunity	-	-	-	-	-	-	-	-	-	-	-	-	Abi
HKD3_k127_6288657_11	497964.CfE428DRAFT_4530	4.693e-47	173.0	COG1331@1|root,COG1331@2|Bacteria,46SEJ@74201|Verrucomicrobia	74201|Verrucomicrobia	O	Protein of unknown function, DUF255	-	-	-	-	-	-	-	-	-	-	-	-	Thioredox_DsbH
HKD3_k127_6291001_42	395964.KE386496_gene104	1.01e-13	71.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,2TRZD@28211|Alphaproteobacteria,3NC0G@45404|Beijerinckiaceae	28211|Alphaproteobacteria	P	Cation transporter/ATPase, N-terminus	-	-	3.6.3.6	ko:K01535	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.3.3	-	-	Cation_ATPase_N,E1-E2_ATPase,Hydrolase
HKD3_k127_6291001_14	234267.Acid_4868	1.046e-118	389.0	COG2326@1|root,COG2326@2|Bacteria,3Y5E4@57723|Acidobacteria	57723|Acidobacteria	S	Polyphosphate kinase 2 (PPK2)	-	-	2.7.4.1	ko:K22468	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PPK2
HKD3_k127_6291001_12	637389.Acaty_c0368	2.665e-125	417.0	COG0477@1|root,COG0477@2|Bacteria,1NS3F@1224|Proteobacteria,1RQRF@1236|Gammaproteobacteria,2NBX2@225057|Acidithiobacillales	225057|Acidithiobacillales	EGP	Sugar (and other) transporter	-	-	-	-	-	-	-	-	-	-	-	-	Sugar_tr
HKD3_k127_6291001_35	1191523.MROS_0856	1.647e-34	138.0	COG2606@1|root,COG2606@2|Bacteria	2|Bacteria	S	Cys-tRNA(Pro) hydrolase activity	-	-	-	ko:K03976,ko:K19055	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_edit
HKD3_k127_6291001_7	497964.CfE428DRAFT_2621	2.765e-166	535.0	COG1030@1|root,COG1030@2|Bacteria,46TAS@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	ko:K07403	-	-	-	-	ko00000	-	-	-	NfeD,SDH_sah
HKD3_k127_6291001_4	497964.CfE428DRAFT_4705	9.863e-195	632.0	COG4775@1|root,COG4775@2|Bacteria,46S5F@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Outer membrane protein assembly complex, YaeT protein	-	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
HKD3_k127_6291001_32	497964.CfE428DRAFT_4704	1.718e-46	176.0	COG2825@1|root,COG2825@2|Bacteria,46T22@74201|Verrucomicrobia	74201|Verrucomicrobia	M	PFAM outer membrane chaperone Skp (OmpH)	hlpA	-	-	ko:K06142	-	-	-	-	ko00000	-	-	-	OmpH
HKD3_k127_6291001_23	497964.CfE428DRAFT_3463	1.69e-64	230.0	29XKE@1|root,30JBI@2|Bacteria,46WEB@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Protein of unknown function (DUF3108)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3108
HKD3_k127_6291001_38	497964.CfE428DRAFT_3464	8.415e-28	122.0	COG4249@1|root,COG4249@2|Bacteria,46WW5@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Putative peptidoglycan binding domain	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_1
HKD3_k127_6291001_30	497964.CfE428DRAFT_3465	4.835e-47	179.0	COG0860@1|root,COG0860@2|Bacteria,46VNJ@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Ami_3	-	-	-	-	-	-	-	-	-	-	-	-	Amidase_3
HKD3_k127_6291001_18	497964.CfE428DRAFT_3466	1.15e-90	308.0	COG0638@1|root,COG0638@2|Bacteria,46VYB@74201|Verrucomicrobia	74201|Verrucomicrobia	O	Proteasome subunit	-	-	3.4.25.1	ko:K03432	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome
HKD3_k127_6291001_16	497964.CfE428DRAFT_3467	3.478e-108	359.0	COG0638@1|root,COG0638@2|Bacteria,46UC7@74201|Verrucomicrobia	74201|Verrucomicrobia	O	Proteasome subunit	-	-	3.4.25.1	ko:K03433	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome
HKD3_k127_6291001_39	497964.CfE428DRAFT_3468	1.401e-25	107.0	2ERDX@1|root,33IZH@2|Bacteria,46WUJ@74201|Verrucomicrobia	74201|Verrucomicrobia	S	May function as a protein modifier covalently attached to lysine residues of substrate proteins. This may serve to target the modified proteins for degradation by proteasomes	ubact	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_6291001_34	497964.CfE428DRAFT_3470	8.463e-43	162.0	2C7E5@1|root,34B8M@2|Bacteria,46W92@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_6291001_3	497964.CfE428DRAFT_2944	2.4e-242	764.0	COG1132@1|root,COG1132@2|Bacteria,46TV7@74201|Verrucomicrobia	74201|Verrucomicrobia	V	ABC transporter transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
HKD3_k127_6291001_46	1122201.AUAZ01000003_gene1901	1.41e-10	66.0	COG1539@1|root,COG1539@2|Bacteria,1MZ8Z@1224|Proteobacteria,1S9B2@1236|Gammaproteobacteria,467QU@72275|Alteromonadaceae	1236|Gammaproteobacteria	H	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin	folB	GO:0003674,GO:0003824,GO:0004150,GO:0005488,GO:0005515,GO:0016829,GO:0016830,GO:0016832,GO:0042802	1.13.11.81,4.1.2.25,5.1.99.8	ko:K01633	ko00790,ko01100,map00790,map01100	M00126,M00840	R03504,R11037,R11073	RC00721,RC00943,RC01479,RC03333,RC03334	ko00000,ko00001,ko00002,ko01000	-	-	iECDH1ME8569_1439.ECDH1ME8569_2955,iECSE_1348.ECSE_3338,iPC815.YPO0648,iSBO_1134.SBO_2914,iSDY_1059.SDY_3241,iSFxv_1172.SFxv_3403,iUTI89_1310.UTI89_C3494,iYL1228.KPN_03462,ic_1306.c3808	FolB
HKD3_k127_6291001_26	497964.CfE428DRAFT_4717	1.761e-57	207.0	COG0494@1|root,COG0494@2|Bacteria	2|Bacteria	L	nUDIX hydrolase	nudF_1	-	3.6.1.13	ko:K01515	ko00230,map00230	-	R01054	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX
HKD3_k127_6291001_25	497964.CfE428DRAFT_5780	1.404e-59	215.0	COG0805@1|root,COG0805@2|Bacteria,46T26@74201|Verrucomicrobia	74201|Verrucomicrobia	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes	tatC	-	-	ko:K03118	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	TatC
HKD3_k127_6291001_11	497964.CfE428DRAFT_2138	1.301e-125	412.0	COG1989@1|root,COG1989@2|Bacteria,46TWT@74201|Verrucomicrobia	74201|Verrucomicrobia	NOU	Type IV leader peptidase family	-	-	3.4.23.43	ko:K02654	-	M00331	-	-	ko00000,ko00002,ko01000,ko01002,ko02035,ko02044	3.A.15.2	-	-	DiS_P_DiS,Peptidase_A24
HKD3_k127_6291001_37	497964.CfE428DRAFT_5396	2.975e-32	131.0	2DQE3@1|root,3368V@2|Bacteria,46WIA@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_6291001_9	1396141.BATP01000007_gene5592	2.459e-139	462.0	COG0644@1|root,COG0644@2|Bacteria,46TJ0@74201|Verrucomicrobia,2IV4G@203494|Verrucomicrobiae	2|Bacteria	C	Tryptophan halogenase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3,Trp_halogenase
HKD3_k127_6291001_13	497964.CfE428DRAFT_2574	3.119e-122	403.0	COG1820@1|root,COG1820@2|Bacteria	2|Bacteria	G	Belongs to the metallo-dependent hydrolases superfamily. NagA family	nagA	-	3.5.1.25	ko:K01443	ko00520,ko01130,map00520,map01130	-	R02059	RC00166,RC00300	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
HKD3_k127_6291001_20	497964.CfE428DRAFT_6628	1.81e-79	278.0	COG0707@1|root,COG0707@2|Bacteria,46SK7@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Monogalactosyldiacylglycerol (MGDG) synthase	-	-	2.4.1.315	ko:K03429	ko00561,ko01100,map00561,map01100	-	R02689,R04377	RC00005,RC00059	ko00000,ko00001,ko01000,ko01003	-	GT28	-	Glyco_tran_28_C,Glyco_trans_1_4,MGDG_synth
HKD3_k127_6291001_40	1123230.ARQJ01000010_gene909	3.597e-25	116.0	COG1295@1|root,COG1295@2|Bacteria,1U7HM@1239|Firmicutes,4H9MJ@91061|Bacilli,4GX76@90964|Staphylococcaceae	91061|Bacilli	S	Belongs to the UPF0761 family	yihY	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Virul_fac_BrkB
HKD3_k127_6291001_28	497964.CfE428DRAFT_5732	1.671e-51	198.0	COG0810@1|root,COG1388@1|root,COG0810@2|Bacteria,COG1388@2|Bacteria,46T61@74201|Verrucomicrobia	74201|Verrucomicrobia	M	N-acetylmuramoyl-L-alanine amidase	-	-	-	-	-	-	-	-	-	-	-	-	Amidase_2,LysM
HKD3_k127_6291001_19	196490.AUEZ01000066_gene2443	5.666e-86	307.0	28J0S@1|root,2Z8XX@2|Bacteria,1P9IP@1224|Proteobacteria,2TSZQ@28211|Alphaproteobacteria,3JVZV@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_6291001_8	670307.HYPDE_29508	1.363e-150	488.0	COG0531@1|root,COG0531@2|Bacteria,1MXNJ@1224|Proteobacteria,2VDGB@28211|Alphaproteobacteria,3N7P3@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	amino acid	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
HKD3_k127_6291001_36	497964.CfE428DRAFT_4835	4.329e-33	134.0	COG4747@1|root,COG4747@2|Bacteria,46WIS@74201|Verrucomicrobia	74201|Verrucomicrobia	S	ACT domain	-	-	-	-	-	-	-	-	-	-	-	-	ACT
HKD3_k127_6291001_29	316067.Geob_2819	2.709e-50	184.0	COG3034@1|root,COG3034@2|Bacteria,1MXY6@1224|Proteobacteria,42TV7@68525|delta/epsilon subdivisions,2WRW0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	YkuD
HKD3_k127_6291001_0	479434.Sthe_2691	1.258e-306	955.0	COG1523@1|root,COG1523@2|Bacteria,2G86B@200795|Chloroflexi	200795|Chloroflexi	G	Belongs to the glycosyl hydrolase 13 family	-	-	3.2.1.68	ko:K01214	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
HKD3_k127_6291001_41	65093.PCC7418_3764	4.287e-24	107.0	COG1278@1|root,COG1278@2|Bacteria,1G5DM@1117|Cyanobacteria	1117|Cyanobacteria	K	'Cold-shock' DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	CSD,Ribosomal_S30AE
HKD3_k127_6291001_10	338963.Pcar_1732	9.512e-137	440.0	COG0685@1|root,COG0685@2|Bacteria,1MUC9@1224|Proteobacteria,42P5X@68525|delta/epsilon subdivisions,2WIQW@28221|Deltaproteobacteria,43V2E@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Methylenetetrahydrofolate reductase	metF	-	1.5.1.20	ko:K00297	ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523	M00377	R01224,R07168	RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	MTHFR
HKD3_k127_6291001_24	497964.CfE428DRAFT_6271	6.318e-64	227.0	COG0398@1|root,COG0398@2|Bacteria,46WAK@74201|Verrucomicrobia	74201|Verrucomicrobia	S	PFAM SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
HKD3_k127_6291001_2	497964.CfE428DRAFT_6356	2.124e-256	804.0	COG0445@1|root,COG0445@2|Bacteria,46SID@74201|Verrucomicrobia	74201|Verrucomicrobia	D	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34	gidA	-	-	ko:K03495	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko03016,ko03036	-	-	-	GIDA,GIDA_assoc
HKD3_k127_6291001_33	240016.ABIZ01000001_gene1711	2.318e-45	171.0	COG0344@1|root,COG0344@2|Bacteria,46VTA@74201|Verrucomicrobia,2IUDC@203494|Verrucomicrobiae	203494|Verrucomicrobiae	I	Glycerol-3-phosphate acyltransferase	-	-	2.3.1.15	ko:K08591	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	G3P_acyltransf
HKD3_k127_6291001_15	497964.CfE428DRAFT_3158	3.102e-109	367.0	COG0240@1|root,COG0240@2|Bacteria,46SQJ@74201|Verrucomicrobia	74201|Verrucomicrobia	C	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus	gpsA	-	1.1.1.94	ko:K00057	ko00564,ko01110,map00564,map01110	-	R00842,R00844	RC00029	ko00000,ko00001,ko01000	-	-	-	NAD_Gly3P_dh_C,NAD_Gly3P_dh_N
HKD3_k127_6291001_21	497964.CfE428DRAFT_0202	6.581e-72	247.0	COG0299@1|root,COG0299@2|Bacteria,46SS6@74201|Verrucomicrobia	74201|Verrucomicrobia	F	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate	purN	-	2.1.2.2	ko:K11175	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	M00048	R04325,R04326	RC00026,RC00197,RC01128	ko00000,ko00001,ko00002,ko01000	-	-	-	Formyl_trans_N
HKD3_k127_6291001_31	497964.CfE428DRAFT_0201	9.925e-47	173.0	COG0615@1|root,COG0615@2|Bacteria,46SUW@74201|Verrucomicrobia	74201|Verrucomicrobia	IM	Cytidylyltransferase-like	-	-	-	-	-	-	-	-	-	-	-	-	CTP_transf_like,Formyl_trans_N
HKD3_k127_6291001_48	497964.CfE428DRAFT_4931	1.274e-07	62.0	COG3330@1|root,COG3330@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF4912)	-	-	-	ko:K09942	-	-	-	-	ko00000	-	-	-	DUF4912,Rho_N
HKD3_k127_6291001_6	886293.Sinac_4878	5.652e-168	546.0	COG0531@1|root,COG0531@2|Bacteria,2IXT5@203682|Planctomycetes	203682|Planctomycetes	E	PFAM Amino acid permease	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
HKD3_k127_6291001_5	234267.Acid_1245	2.546e-186	595.0	COG0531@1|root,COG0531@2|Bacteria,3Y3QM@57723|Acidobacteria	57723|Acidobacteria	E	amino acid	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
HKD3_k127_6291001_45	391008.Smal_3810	1.294e-10	74.0	COG0793@1|root,COG0793@2|Bacteria,1N4T9@1224|Proteobacteria,1SE36@1236|Gammaproteobacteria,1X70X@135614|Xanthomonadales	135614|Xanthomonadales	M	Aspartyl protease	-	-	-	-	-	-	-	-	-	-	-	-	Asp_protease_2,PDZ_2
HKD3_k127_6291001_22	478741.JAFS01000001_gene1471	9.422e-68	242.0	COG1208@1|root,COG1208@2|Bacteria,46SJP@74201|Verrucomicrobia	74201|Verrucomicrobia	JM	Nucleotidyl transferase	-	-	2.7.7.13	ko:K00966	ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110	M00114,M00361,M00362	R00885	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
HKD3_k127_6291001_17	497964.CfE428DRAFT_3037	5.415e-107	361.0	COG3178@1|root,COG3178@2|Bacteria,46SU7@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Phosphotransferase enzyme family	-	-	2.7.1.221	ko:K07102	ko00520,ko01100,map00520,map01100	-	R08968,R11024	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	APH
HKD3_k127_6291001_1	497964.CfE428DRAFT_3497	6.662e-277	866.0	COG0465@1|root,COG0465@2|Bacteria,46SB7@74201|Verrucomicrobia	74201|Verrucomicrobia	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,Peptidase_M41
HKD3_k127_6291001_27	118173.KB235914_gene3364	2.09e-53	190.0	COG4974@1|root,COG4974@2|Bacteria,1G224@1117|Cyanobacteria,1H8SW@1150|Oscillatoriales	1117|Cyanobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_4,Phage_integrase
HKD3_k127_6291001_43	1385935.N836_14975	1.445e-13	71.0	COG4974@1|root,COG4974@2|Bacteria,1G224@1117|Cyanobacteria,1H8SW@1150|Oscillatoriales	1117|Cyanobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_4,Phage_integrase
HKD3_k127_6323417_83	416348.Hlac_2783	1.946e-09	61.0	arCOG08094@1|root,arCOG08094@2157|Archaea,2Y0PB@28890|Euryarchaeota,23YAM@183963|Halobacteria	183963|Halobacteria	S	KTSC domain	-	-	-	-	-	-	-	-	-	-	-	-	KTSC
HKD3_k127_6323417_72	497964.CfE428DRAFT_6335	2.374e-26	113.0	COG0319@1|root,COG0319@2|Bacteria,46WBN@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA	ybeY	-	-	ko:K07042	-	-	-	-	ko00000,ko03009	-	-	-	UPF0054
HKD3_k127_6323417_62	497964.CfE428DRAFT_6333	4.865e-35	137.0	COG2127@1|root,COG2127@2|Bacteria,46T8N@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation	clpS	-	-	ko:K06891	-	-	-	-	ko00000	-	-	-	ClpS
HKD3_k127_6323417_50	497964.CfE428DRAFT_2380	5.386e-54	198.0	COG1595@1|root,COG1595@2|Bacteria,46VRK@74201|Verrucomicrobia	74201|Verrucomicrobia	K	TIGRFAM RNA polymerase sigma factor, sigma-70 family	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD3_k127_6323417_0	247490.KSU1_C1304	0.0	1330.0	COG0366@1|root,COG3281@1|root,COG0366@2|Bacteria,COG3281@2|Bacteria,2IXJN@203682|Planctomycetes	203682|Planctomycetes	G	alpha amylase catalytic	-	-	3.2.1.1,3.2.1.10,5.4.99.16	ko:K01182,ko:K05343	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00801,R01557,R01718,R01791,R02108,R02112,R06199,R11262	RC00028,RC00059,RC00077,RC00451,RC01816	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,DUF3459,Malt_amylase_C
HKD3_k127_6323417_32	1267535.KB906767_gene4015	1.545e-82	280.0	COG5424@1|root,COG5424@2|Bacteria,3Y718@57723|Acidobacteria,2JKMM@204432|Acidobacteriia	204432|Acidobacteriia	H	Iron-containing redox enzyme	-	-	1.3.3.11	ko:K06137	-	-	-	-	ko00000,ko01000	-	-	-	Haem_oxygenas_2
HKD3_k127_6323417_35	330214.NIDE2979	1.342e-79	284.0	COG0265@1|root,COG0265@2|Bacteria,3J0X9@40117|Nitrospirae	2|Bacteria	M	Evidence 2a Function of homologous gene experimentally demonstrated in an other organism	htrA	GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ,PDZ_2,Trypsin_2
HKD3_k127_6323417_2	497964.CfE428DRAFT_3042	1.331e-243	781.0	COG1200@1|root,COG1200@2|Bacteria,46TTC@74201|Verrucomicrobia	74201|Verrucomicrobia	L	RecG wedge domain	-	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge
HKD3_k127_6323417_11	349741.Amuc_0051	2.386e-161	525.0	COG0608@1|root,COG0608@2|Bacteria,46SNV@74201|Verrucomicrobia,2ITRD@203494|Verrucomicrobiae	203494|Verrucomicrobiae	L	DHHA1 domain	-	-	-	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
HKD3_k127_6323417_46	497964.CfE428DRAFT_1105	2.057e-60	218.0	COG1427@1|root,COG1427@2|Bacteria,46VTU@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)	mqnA	-	4.2.1.151	ko:K11782	ko00130,ko01110,map00130,map01110	-	R10666	RC03232	ko00000,ko00001,ko01000	-	-	-	VitK2_biosynth
HKD3_k127_6323417_12	497964.CfE428DRAFT_1106	3.219e-152	490.0	COG1060@1|root,COG1060@2|Bacteria,46TD4@74201|Verrucomicrobia	74201|Verrucomicrobia	H	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate	mqnE	-	2.5.1.120	ko:K18285	ko00130,ko01110,map00130,map01110	-	R10667	RC00021,RC03234	ko00000,ko00001,ko01000	-	-	-	Radical_SAM
HKD3_k127_6323417_47	497964.CfE428DRAFT_1107	7.208e-60	213.0	COG1595@1|root,COG1595@2|Bacteria,46SZG@74201|Verrucomicrobia	74201|Verrucomicrobia	K	TIGRFAM RNA polymerase sigma factor, sigma-70 family	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD3_k127_6323417_76	335543.Sfum_0487	4.871e-19	92.0	COG1950@1|root,COG1950@2|Bacteria,1N1DF@1224|Proteobacteria,42WCF@68525|delta/epsilon subdivisions,2WRES@28221|Deltaproteobacteria,2MQP9@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Mycobacterial 4 TMS phage holin, superfamily IV	-	-	-	ko:K08972	-	-	-	-	ko00000	-	-	-	Phage_holin_4_2
HKD3_k127_6323417_24	497964.CfE428DRAFT_0510	1.932e-100	330.0	COG0522@1|root,COG0522@2|Bacteria,46SNI@74201|Verrucomicrobia	74201|Verrucomicrobia	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit	rpsD	-	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S4,S4
HKD3_k127_6323417_45	497964.CfE428DRAFT_0509	2.131e-63	226.0	COG0100@1|root,COG0100@2|Bacteria,46STW@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome	rpsK	-	-	ko:K02948	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S11
HKD3_k127_6323417_49	497964.CfE428DRAFT_0508	2.424e-55	196.0	COG0099@1|root,COG0099@2|Bacteria,46STA@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits	rpsM	-	-	ko:K02952	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13
HKD3_k127_6323417_80	1125863.JAFN01000001_gene3318	4.374e-12	66.0	COG0257@1|root,COG0257@2|Bacteria,1NGEI@1224|Proteobacteria,42WXD@68525|delta/epsilon subdivisions,2WSYK@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	Belongs to the bacterial ribosomal protein bL36 family	rpmJ	-	-	ko:K02919	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L36
HKD3_k127_6323417_18	497964.CfE428DRAFT_0506	7.611e-120	389.0	COG0024@1|root,COG0024@2|Bacteria,46SK6@74201|Verrucomicrobia	74201|Verrucomicrobia	J	TIGRFAM methionine aminopeptidase, type I	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
HKD3_k127_6323417_56	1317124.DW2_06393	1.008e-46	175.0	COG0563@1|root,COG0563@2|Bacteria,1MXCZ@1224|Proteobacteria,2TT6A@28211|Alphaproteobacteria,2XM3X@285107|Thioclava	28211|Alphaproteobacteria	F	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism	adk	-	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ADK,ADK_lid
HKD3_k127_6323417_4	497964.CfE428DRAFT_0505	9.455e-227	712.0	COG0201@1|root,COG0201@2|Bacteria,46S86@74201|Verrucomicrobia	74201|Verrucomicrobia	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	-	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	SecY
HKD3_k127_6323417_51	497964.CfE428DRAFT_0504	3.085e-53	194.0	COG0200@1|root,COG0200@2|Bacteria,46SSX@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Binds to the 23S rRNA	rplO	-	-	ko:K02876	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27A
HKD3_k127_6323417_43	497964.CfE428DRAFT_0503	3.724e-66	230.0	COG0098@1|root,COG0098@2|Bacteria,46SUR@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body	rpsE	-	-	ko:K02988	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S5,Ribosomal_S5_C
HKD3_k127_6323417_64	2423.NA23_0208125	6.826e-34	136.0	COG0256@1|root,COG0256@2|Bacteria,2GD32@200918|Thermotogae	200918|Thermotogae	J	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance	rplR	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008097,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904	-	ko:K02881	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18p
HKD3_k127_6323417_37	497964.CfE428DRAFT_0501	4.879e-74	253.0	COG0097@1|root,COG0097@2|Bacteria,46SP9@74201|Verrucomicrobia	74201|Verrucomicrobia	J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center	rplF	-	-	ko:K02933	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L6
HKD3_k127_6323417_53	497964.CfE428DRAFT_0500	1.126e-52	188.0	COG0096@1|root,COG0096@2|Bacteria,46T2K@74201|Verrucomicrobia	74201|Verrucomicrobia	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit	rpsH	-	-	ko:K02994	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8
HKD3_k127_6323417_36	497964.CfE428DRAFT_0499	1.174e-77	263.0	COG0094@1|root,COG0094@2|Bacteria,46SP7@74201|Verrucomicrobia	74201|Verrucomicrobia	J	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits	rplE	-	-	ko:K02931	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L5,Ribosomal_L5_C
HKD3_k127_6323417_71	497964.CfE428DRAFT_0498	1.901e-26	113.0	COG0198@1|root,COG0198@2|Bacteria,46T3M@74201|Verrucomicrobia	74201|Verrucomicrobia	J	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit	rplX	-	-	ko:K02895	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KOW,ribosomal_L24
HKD3_k127_6323417_48	497964.CfE428DRAFT_0497	1.782e-57	202.0	COG0093@1|root,COG0093@2|Bacteria,46VID@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome	rplN	-	-	ko:K02874	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L14
HKD3_k127_6323417_70	497964.CfE428DRAFT_0496	1.434e-27	114.0	COG0186@1|root,COG0186@2|Bacteria,46T6M@74201|Verrucomicrobia	74201|Verrucomicrobia	J	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA	rpsQ	-	-	ko:K02961	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17
HKD3_k127_6323417_79	497964.CfE428DRAFT_0495	4.721e-15	77.0	COG0255@1|root,COG0255@2|Bacteria,46TAV@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Ribosomal L29 protein	rpmC	-	-	ko:K02904	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L29
HKD3_k127_6323417_38	497964.CfE428DRAFT_0494	5.83e-74	250.0	COG0197@1|root,COG0197@2|Bacteria,46ST6@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs	rplP	-	-	ko:K02878	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L16
HKD3_k127_6323417_22	497964.CfE428DRAFT_0493	1.151e-109	358.0	COG0092@1|root,COG0092@2|Bacteria,46SN9@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation	rpsC	-	-	ko:K02982	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KH_2,Ribosomal_S3_C
HKD3_k127_6323417_60	497964.CfE428DRAFT_0492	8.309e-43	162.0	COG0091@1|root,COG0091@2|Bacteria,46T5F@74201|Verrucomicrobia	74201|Verrucomicrobia	J	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome	rplV	-	-	ko:K02890	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L22
HKD3_k127_6323417_68	497964.CfE428DRAFT_0491	1.527e-29	128.0	2FI21@1|root,349UX@2|Bacteria,46W3I@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_6323417_59	1156937.MFUM_870039	7.627e-43	158.0	COG0185@1|root,COG0185@2|Bacteria,46T4G@74201|Verrucomicrobia,37GV3@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	J	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA	rpsS	-	-	ko:K02965	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19
HKD3_k127_6323417_16	497964.CfE428DRAFT_0489	1.424e-130	421.0	COG0090@1|root,COG0090@2|Bacteria,46S71@74201|Verrucomicrobia	74201|Verrucomicrobia	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity	rplB	-	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
HKD3_k127_6323417_67	497964.CfE428DRAFT_0488	4.58e-30	127.0	COG0089@1|root,COG0089@2|Bacteria,46WBX@74201|Verrucomicrobia	74201|Verrucomicrobia	J	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome	rplW	-	-	ko:K02892	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L23
HKD3_k127_6323417_39	497964.CfE428DRAFT_0487	9.281e-72	248.0	COG0088@1|root,COG0088@2|Bacteria,46SWJ@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Forms part of the polypeptide exit tunnel	rplD	-	-	ko:K02926	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L4
HKD3_k127_6323417_29	497964.CfE428DRAFT_0486	4.374e-89	299.0	COG0087@1|root,COG0087@2|Bacteria,46SQV@74201|Verrucomicrobia	74201|Verrucomicrobia	J	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rplC	-	-	ko:K02906	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L3
HKD3_k127_6323417_54	497964.CfE428DRAFT_0485	1.159e-48	186.0	COG0051@1|root,COG0051@2|Bacteria,46SVV@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Involved in the binding of tRNA to the ribosomes	rpsJ	-	-	ko:K02946	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S10
HKD3_k127_6323417_1	497964.CfE428DRAFT_0484	0.0	1178.0	COG0480@1|root,COG0480@2|Bacteria,46SFV@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
HKD3_k127_6323417_42	497964.CfE428DRAFT_0483	1.262e-67	233.0	COG0049@1|root,COG0049@2|Bacteria,46V3W@74201|Verrucomicrobia	74201|Verrucomicrobia	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA	rpsG	-	-	ko:K02992	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S7
HKD3_k127_6323417_41	497964.CfE428DRAFT_0482	2.596e-68	237.0	COG0048@1|root,COG0048@2|Bacteria,46SQR@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit	rpsL	-	-	ko:K02950	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosom_S12_S23
HKD3_k127_6323417_8	497964.CfE428DRAFT_5931	6.559e-171	544.0	COG0343@1|root,COG0343@2|Bacteria,46TZR@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)	tgt	-	2.4.2.29	ko:K00773	-	-	R03789,R10209	RC00063	ko00000,ko01000,ko03016	-	-	-	TGT
HKD3_k127_6323417_25	497964.CfE428DRAFT_1198	3.822e-100	331.0	COG0639@1|root,COG0639@2|Bacteria,46TA5@74201|Verrucomicrobia	74201|Verrucomicrobia	T	Calcineurin-like phosphoesterase superfamily domain	apaH	-	-	-	-	-	-	-	-	-	-	-	Metallophos_2
HKD3_k127_6323417_33	497964.CfE428DRAFT_1199	9.557e-81	278.0	COG0457@1|root,COG0457@2|Bacteria,46VY0@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_6323417_30	497964.CfE428DRAFT_1200	7.739e-88	299.0	COG1277@1|root,COG1277@2|Bacteria,46VKD@74201|Verrucomicrobia	74201|Verrucomicrobia	S	ABC-type transport system involved in multi-copper enzyme maturation permease component	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane_2
HKD3_k127_6323417_21	497964.CfE428DRAFT_1201	3.087e-113	372.0	COG1131@1|root,COG1131@2|Bacteria,46SHV@74201|Verrucomicrobia	74201|Verrucomicrobia	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD3_k127_6323417_74	497964.CfE428DRAFT_1202	8.225e-23	102.0	COG1254@1|root,COG1254@2|Bacteria,46W9W@74201|Verrucomicrobia	74201|Verrucomicrobia	C	Belongs to the acylphosphatase family	acyP	-	3.6.1.7	ko:K01512	ko00620,ko00627,ko01120,map00620,map00627,map01120	-	R00317,R01421,R01515	RC00043	ko00000,ko00001,ko01000	-	-	-	Acylphosphatase
HKD3_k127_6323417_40	497964.CfE428DRAFT_0822	8.478e-71	248.0	2F4CA@1|root,342S4@2|Bacteria,46VXA@74201|Verrucomicrobia	497964.CfE428DRAFT_0822|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_6323417_7	349741.Amuc_1184	6.953e-183	580.0	COG0148@1|root,COG0148@2|Bacteria,46S7N@74201|Verrucomicrobia,2ITUV@203494|Verrucomicrobiae	203494|Verrucomicrobiae	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	-	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
HKD3_k127_6323417_13	240016.ABIZ01000001_gene923	9.277e-140	452.0	COG1186@1|root,COG1186@2|Bacteria,46SAW@74201|Verrucomicrobia,2ITHK@203494|Verrucomicrobiae	203494|Verrucomicrobiae	J	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA	prfB	-	-	ko:K02836	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
HKD3_k127_6323417_55	497964.CfE428DRAFT_1903	4.956e-48	181.0	COG1104@1|root,COG1104@2|Bacteria,46TNH@74201|Verrucomicrobia	74201|Verrucomicrobia	E	Aminotransferase class-V	-	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
HKD3_k127_6323417_15	497964.CfE428DRAFT_1903	7.345e-132	430.0	COG1104@1|root,COG1104@2|Bacteria,46TNH@74201|Verrucomicrobia	74201|Verrucomicrobia	E	Aminotransferase class-V	-	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
HKD3_k127_6323417_26	497964.CfE428DRAFT_1905	5.182e-98	332.0	COG1045@1|root,COG1045@2|Bacteria,46S5J@74201|Verrucomicrobia	74201|Verrucomicrobia	E	Bacterial transferase hexapeptide (six repeats)	cysE	-	2.3.1.30	ko:K00640	ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111	M00021	R00586	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,SATase_N
HKD3_k127_6323417_78	1123389.ATXJ01000004_gene1263	3.305e-17	87.0	2DUIA@1|root,32UXB@2|Bacteria,1WK6Z@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	SPW repeat	-	-	-	-	-	-	-	-	-	-	-	-	SPW
HKD3_k127_6323417_77	497964.CfE428DRAFT_1695	5.803e-19	98.0	COG1196@1|root,COG1196@2|Bacteria,46Z83@74201|Verrucomicrobia	74201|Verrucomicrobia	D	nuclear chromosome segregation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_6323417_58	497964.CfE428DRAFT_5968	3.41e-43	162.0	COG3688@1|root,COG3688@2|Bacteria,46T34@74201|Verrucomicrobia	74201|Verrucomicrobia	S	YacP-like NYN domain	-	-	-	ko:K06962	-	-	-	-	ko00000	-	-	-	NYN_YacP
HKD3_k127_6323417_17	497964.CfE428DRAFT_4703	2.933e-126	412.0	COG1044@1|root,COG1044@2|Bacteria,46SAD@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxD	-	2.3.1.191	ko:K02536	ko00540,ko01100,map00540,map01100	M00060	R04550	RC00039,RC00166	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hexapep,LpxD
HKD3_k127_6323417_19	395495.Lcho_2075	7.897e-116	379.0	COG1024@1|root,COG1024@2|Bacteria,1MUJ7@1224|Proteobacteria,2VIP5@28216|Betaproteobacteria,1KJZ0@119065|unclassified Burkholderiales	28216|Betaproteobacteria	I	enoyl-CoA hydratase	fadB3	-	-	-	-	-	-	-	-	-	-	-	ECH_1
HKD3_k127_6323417_27	497964.CfE428DRAFT_5497	1.406e-97	327.0	COG1192@1|root,COG1192@2|Bacteria,46SKQ@74201|Verrucomicrobia	74201|Verrucomicrobia	D	PFAM Cobyrinic acid ac-diamide synthase	soj	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
HKD3_k127_6323417_69	1174528.JH992898_gene3078	2.289e-29	126.0	COG1670@1|root,COG1670@2|Bacteria,1G63R@1117|Cyanobacteria,1JJYB@1189|Stigonemataceae	1117|Cyanobacteria	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
HKD3_k127_6323417_34	404589.Anae109_2572	1.364e-80	275.0	COG1573@1|root,COG1573@2|Bacteria,1MW8T@1224|Proteobacteria,42ZZ6@68525|delta/epsilon subdivisions,2WV5A@28221|Deltaproteobacteria,2YZAW@29|Myxococcales	28221|Deltaproteobacteria	L	Uracil DNA glycosylase superfamily	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
HKD3_k127_6323417_44	497964.CfE428DRAFT_4693	6.122e-65	229.0	COG1211@1|root,COG1211@2|Bacteria,46T2A@74201|Verrucomicrobia	74201|Verrucomicrobia	I	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP)	ispD	-	2.7.7.60	ko:K00991	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	IspD
HKD3_k127_6323417_66	1242864.D187_008790	3.966e-30	124.0	COG1610@1|root,COG1610@2|Bacteria,1RGZS@1224|Proteobacteria,42SH8@68525|delta/epsilon subdivisions,2WQ3S@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Yqey-like protein	yqeY	-	-	ko:K09117	-	-	-	-	ko00000	-	-	-	YqeY
HKD3_k127_6323417_57	1123073.KB899243_gene595	2.325e-44	175.0	COG2120@1|root,COG2120@2|Bacteria,1PGKP@1224|Proteobacteria,1RXHM@1236|Gammaproteobacteria,1X6FI@135614|Xanthomonadales	135614|Xanthomonadales	S	GlcNAc-PI de-N-acetylase	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
HKD3_k127_6323417_28	497964.CfE428DRAFT_2977	3.42e-93	329.0	COG1807@1|root,COG1807@2|Bacteria	2|Bacteria	M	4-amino-4-deoxy-L-arabinose transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HKD3_k127_6323417_23	497964.CfE428DRAFT_0542	1.515e-103	345.0	COG0331@1|root,COG0331@2|Bacteria,46SNS@74201|Verrucomicrobia	74201|Verrucomicrobia	I	Acyl transferase domain	fabD	-	2.3.1.39	ko:K00645	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	M00082	R01626,R11671	RC00004,RC00039,RC02727	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyl_transf_1
HKD3_k127_6323417_6	497964.CfE428DRAFT_0519	2.941e-209	657.0	COG0649@1|root,COG0649@2|Bacteria,46SA0@74201|Verrucomicrobia	74201|Verrucomicrobia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoD	-	1.6.5.3	ko:K00333	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa
HKD3_k127_6323417_85	748280.NH8B_2321	2.902e-05	50.0	COG2913@1|root,COG2913@2|Bacteria,1NMHT@1224|Proteobacteria,2VYJY@28216|Betaproteobacteria,2KTFJ@206351|Neisseriales	206351|Neisseriales	J	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_6323417_5	1403819.BATR01000090_gene2641	6.224e-211	676.0	COG1894@1|root,COG1894@2|Bacteria,46S8J@74201|Verrucomicrobia,2ITYB@203494|Verrucomicrobiae	203494|Verrucomicrobiae	C	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region	-	-	1.6.5.3	ko:K00335	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_51K,NADH_4Fe-4S,SLBB
HKD3_k127_6323417_65	46234.ANA_C20489	7.71e-31	126.0	COG0614@1|root,COG0614@2|Bacteria,1G79B@1117|Cyanobacteria,1HNFV@1161|Nostocales	1117|Cyanobacteria	P	PD-(D/E)XK nuclease superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_3
HKD3_k127_6323417_3	497964.CfE428DRAFT_0528	1.399e-230	728.0	COG1034@1|root,COG3383@1|root,COG1034@2|Bacteria,COG3383@2|Bacteria,46S6S@74201|Verrucomicrobia	74201|Verrucomicrobia	C	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region	nuoG	-	1.6.5.3	ko:K00336	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer2_4,Molybdop_Fe4S4,Molybdopterin,NADH-G_4Fe-4S_3
HKD3_k127_6323417_14	497964.CfE428DRAFT_0529	9.052e-133	432.0	COG1005@1|root,COG1005@2|Bacteria,46SIJ@74201|Verrucomicrobia	74201|Verrucomicrobia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	nuoH	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
HKD3_k127_6323417_31	497964.CfE428DRAFT_0530	3.944e-84	282.0	COG1143@1|root,COG1143@2|Bacteria,46SNT@74201|Verrucomicrobia	74201|Verrucomicrobia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoI	-	1.6.5.3	ko:K00338	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer4
HKD3_k127_6323417_52	497964.CfE428DRAFT_0531	8.089e-53	191.0	COG0839@1|root,COG0839@2|Bacteria,46VSH@74201|Verrucomicrobia	74201|Verrucomicrobia	C	NADH-ubiquinone/plastoquinone oxidoreductase chain 6	-	-	1.6.5.3	ko:K00339	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q3
HKD3_k127_6323417_63	497964.CfE428DRAFT_0532	7.721e-35	143.0	COG0713@1|root,COG0713@2|Bacteria,46SX4@74201|Verrucomicrobia	74201|Verrucomicrobia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoK	-	1.6.5.3	ko:K00340	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q2
HKD3_k127_6323417_9	497964.CfE428DRAFT_0535	2.862e-170	554.0	COG1009@1|root,COG1009@2|Bacteria,46SDU@74201|Verrucomicrobia	74201|Verrucomicrobia	CP	NADH Ubiquinone plastoquinone (complex I)	nuoL	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M,Proton_antipo_N
HKD3_k127_6323417_10	497964.CfE428DRAFT_0536	3.195e-170	552.0	COG1008@1|root,COG1008@2|Bacteria,46SE4@74201|Verrucomicrobia	74201|Verrucomicrobia	C	TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain M	nuoM	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
HKD3_k127_6323417_20	1396141.BATP01000003_gene5069	1.657e-113	383.0	COG1007@1|root,COG1007@2|Bacteria,46ST5@74201|Verrucomicrobia,2IU1U@203494|Verrucomicrobiae	203494|Verrucomicrobiae	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoN	-	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
HKD3_k127_6323417_73	316274.Haur_4504	5.972e-23	109.0	COG5624@1|root,COG5624@2|Bacteria,2G94N@200795|Chloroflexi,377N8@32061|Chloroflexia	200795|Chloroflexi	K	Conserved repeat domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_6326772_18	1121121.KB894295_gene4395	0.0004981	44.0	2DH1M@1|root,2ZY2Y@2|Bacteria,1W68J@1239|Firmicutes,4I0XP@91061|Bacilli,273X4@186822|Paenibacillaceae	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_6326772_4	1094508.Tsac_0117	9.915e-95	327.0	COG0531@1|root,COG0531@2|Bacteria,1TRFS@1239|Firmicutes,248WW@186801|Clostridia,42HP7@68295|Thermoanaerobacterales	186801|Clostridia	E	PFAM Amino acid	-	-	-	ko:K20265	ko02024,map02024	-	-	-	ko00000,ko00001,ko02000	2.A.3.7.1,2.A.3.7.3	-	-	AA_permease_2
HKD3_k127_6326772_0	1496688.ER33_07135	3.558e-281	887.0	COG3119@1|root,COG3119@2|Bacteria,1G22U@1117|Cyanobacteria,22RRC@167375|Cyanobium	1117|Cyanobacteria	P	Sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
HKD3_k127_6326772_3	497964.CfE428DRAFT_5678	5.12e-116	381.0	COG1116@1|root,COG1116@2|Bacteria,46UXE@74201|Verrucomicrobia	74201|Verrucomicrobia	P	ATPases associated with a variety of cellular activities	-	-	-	ko:K15555	ko00920,ko02010,map00920,map02010	M00436	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.17.2	-	-	ABC_tran
HKD3_k127_6326772_2	497964.CfE428DRAFT_5677	2.221e-134	436.0	COG0600@1|root,COG0600@2|Bacteria,46TTV@74201|Verrucomicrobia	74201|Verrucomicrobia	P	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
HKD3_k127_6326772_1	497964.CfE428DRAFT_5676	4.782e-146	473.0	COG0715@1|root,COG0715@2|Bacteria,46UC9@74201|Verrucomicrobia	74201|Verrucomicrobia	P	NMT1/THI5 like	-	-	-	-	-	-	-	-	-	-	-	-	NMT1
HKD3_k127_6326772_8	330214.NIDE3531	1.809e-48	186.0	COG0583@1|root,COG0583@2|Bacteria,3J16P@40117|Nitrospirae	40117|Nitrospirae	K	Transcriptional regulator	-	-	-	ko:K11921,ko:K19338	-	-	-	-	ko00000,ko03000	-	-	-	HTH_1,LysR_substrate
HKD3_k127_6326772_14	1004149.AFOE01000012_gene1511	2.956e-08	66.0	COG3577@1|root,COG3577@2|Bacteria,4NNI0@976|Bacteroidetes,1I1Z6@117743|Flavobacteriia	976|Bacteroidetes	S	protease	-	-	-	-	-	-	-	-	-	-	-	-	Asp_protease_2
HKD3_k127_6326772_17	706436.HMPREF9074_07560	0.0002248	53.0	COG3577@1|root,COG3577@2|Bacteria,4NNI0@976|Bacteroidetes,1I1Z6@117743|Flavobacteriia,1ES2Q@1016|Capnocytophaga	976|Bacteroidetes	S	gag-polyprotein putative aspartyl protease	-	-	-	-	-	-	-	-	-	-	-	-	Asp_protease_2
HKD3_k127_6326772_7	1248916.ANFY01000010_gene419	2.411e-52	187.0	COG1917@1|root,COG1917@2|Bacteria,1RHHY@1224|Proteobacteria,2UCCW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Cupin 2, conserved barrel	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_3
HKD3_k127_6326772_9	497964.CfE428DRAFT_6548	7.73e-47	173.0	2EH8A@1|root,33B04@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_6326772_6	1297569.MESS2_410026	2.294e-59	210.0	2C4SR@1|root,32TC7@2|Bacteria,1RCZG@1224|Proteobacteria,2U89H@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_6326772_5	204669.Acid345_4420	3.882e-77	266.0	COG1266@1|root,COG1266@2|Bacteria	2|Bacteria	V	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
HKD3_k127_6326772_11	1122137.AQXF01000001_gene2693	9.73e-29	121.0	2EGX5@1|root,33APA@2|Bacteria,1NHMF@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	GGACT
HKD3_k127_6326772_12	1005048.CFU_2898	2.02e-28	118.0	COG0454@1|root,COG0456@2|Bacteria,1N79D@1224|Proteobacteria,2VXGY@28216|Betaproteobacteria,47504@75682|Oxalobacteraceae	28216|Betaproteobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_10
HKD3_k127_6326772_10	214092.YPO0904	1.764e-30	126.0	2E69S@1|root,330XP@2|Bacteria,1N7XM@1224|Proteobacteria,1SDDI@1236|Gammaproteobacteria,41FWR@629|Yersinia	1236|Gammaproteobacteria	S	Lipocalin-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Lipocalin_5
HKD3_k127_6326772_15	1206731.BAGB01000040_gene8085	2.466e-05	51.0	COG4319@1|root,COG4319@2|Bacteria,2II1S@201174|Actinobacteria,4G18S@85025|Nocardiaceae	201174|Actinobacteria	E	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_3
HKD3_k127_6326772_13	1235457.C404_06065	6.969e-17	85.0	COG4319@1|root,COG4319@2|Bacteria,1N99A@1224|Proteobacteria,2VXDG@28216|Betaproteobacteria,1K9XQ@119060|Burkholderiaceae	28216|Betaproteobacteria	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_3
HKD3_k127_6326772_16	566466.NOR53_2496	0.0001077	50.0	2AEZN@1|root,314XR@2|Bacteria,1NSHG@1224|Proteobacteria,1SMR4@1236|Gammaproteobacteria,1J84Y@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_6344564_10	1267534.KB906754_gene3732	9.205e-26	111.0	2DTV5@1|root,33MT0@2|Bacteria,3Y5UW@57723|Acidobacteria,2JNBS@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_6344564_2	1396141.BATP01000060_gene4594	1.54e-74	269.0	COG1459@1|root,COG1459@2|Bacteria,46X1U@74201|Verrucomicrobia,2IU50@203494|Verrucomicrobiae	203494|Verrucomicrobiae	NU	Type II secretion system (T2SS), protein F	-	-	-	-	-	-	-	-	-	-	-	-	T2SSF
HKD3_k127_6344564_6	497964.CfE428DRAFT_5110	5.323e-35	138.0	COG2165@1|root,COG2165@2|Bacteria,46W6A@74201|Verrucomicrobia	74201|Verrucomicrobia	NU	Type II secretion system (T2SS), protein G	-	-	-	ko:K02456	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl,T2SSG
HKD3_k127_6344564_8	497964.CfE428DRAFT_5108	2.337e-30	127.0	2BNE4@1|root,2ZUA2@2|Bacteria,46WGV@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_6344564_5	497964.CfE428DRAFT_5096	5.178e-40	160.0	COG3156@1|root,COG3156@2|Bacteria,46VZT@74201|Verrucomicrobia	74201|Verrucomicrobia	U	Type II secretion system (T2SS), protein K	-	-	-	-	-	-	-	-	-	-	-	-	T2SSK
HKD3_k127_6344564_13	1163409.UUA_11533	3.097e-07	60.0	COG4795@1|root,COG4795@2|Bacteria,1MYPS@1224|Proteobacteria,1SHGQ@1236|Gammaproteobacteria,1X6ZS@135614|Xanthomonadales	135614|Xanthomonadales	U	General secretion pathway protein	xpsJ	-	-	ko:K02459	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl
HKD3_k127_6344564_7	1125973.JNLC01000014_gene2478	4.605e-33	140.0	COG0500@1|root,COG2226@2|Bacteria,1N5QH@1224|Proteobacteria,2UM5M@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_31
HKD3_k127_6344564_1	278963.ATWD01000001_gene4653	1.264e-113	376.0	COG0672@1|root,COG0672@2|Bacteria,3Y78C@57723|Acidobacteria,2JKXR@204432|Acidobacteriia	204432|Acidobacteriia	P	Iron permease FTR1 family	-	-	-	ko:K07243	-	-	-	-	ko00000,ko02000	2.A.108.1,2.A.108.2	-	-	FTR1
HKD3_k127_6344564_0	204669.Acid345_2533	4.853e-241	756.0	COG4447@1|root,COG4447@2|Bacteria,3Y69Z@57723|Acidobacteria	57723|Acidobacteria	S	Sortilin, neurotensin receptor 3,	-	-	-	-	-	-	-	-	-	-	-	-	Sortilin-Vps10
HKD3_k127_6361889_0	1288494.EBAPG3_7100	1.675e-189	612.0	COG0469@1|root,COG0469@2|Bacteria,1NNNX@1224|Proteobacteria,2VNQM@28216|Betaproteobacteria,372BI@32003|Nitrosomonadales	28216|Betaproteobacteria	G	Pyruvate kinase, barrel domain	-	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PK
HKD3_k127_6361889_1	1472716.KBK24_0112340	7.533e-51	184.0	COG0546@1|root,COG0546@2|Bacteria,1QEY0@1224|Proteobacteria,2VJ8N@28216|Betaproteobacteria,1K1RZ@119060|Burkholderiaceae	28216|Betaproteobacteria	S	phosphoglycolate phosphatase activity	-	-	-	-	-	-	-	-	-	-	-	-	HAD
HKD3_k127_6391427_0	478741.JAFS01000002_gene375	1.813e-127	413.0	COG0133@1|root,COG0133@2|Bacteria,46SHR@74201|Verrucomicrobia,37G1U@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB	-	4.2.1.20	ko:K01696	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HKD3_k127_6391427_1	204669.Acid345_1160	5.475e-75	263.0	COG0159@1|root,COG0159@2|Bacteria,3Y3X2@57723|Acidobacteria,2JI7C@204432|Acidobacteriia	204432|Acidobacteriia	E	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate	trpA	-	4.2.1.20	ko:K01695	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_syntA
HKD3_k127_6391427_2	485913.Krac_2641	1.597e-48	176.0	COG1233@1|root,COG1233@2|Bacteria,2G60T@200795|Chloroflexi	200795|Chloroflexi	Q	NAD(P)-binding Rossmann-like domain	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_8
HKD3_k127_6393597_16	1183438.GKIL_0413	2.186e-36	147.0	COG2911@1|root,COG5295@1|root,COG2911@2|Bacteria,COG5295@2|Bacteria	2|Bacteria	UW	Hep Hag repeat protein	-	GO:0005575,GO:0005576	-	-	-	-	-	-	-	-	-	-	CBM_3,CHAT,CHU_C,Cohesin,Peptidase_S74
HKD3_k127_6393597_20	204669.Acid345_0352	8.194e-10	63.0	COG0729@1|root,COG5295@1|root,COG0729@2|Bacteria,COG5295@2|Bacteria	2|Bacteria	UW	Hep Hag repeat protein	yeeJ	-	-	ko:K07278,ko:K21449	-	-	-	-	ko00000,ko02000	1.B.33.2.4,1.B.40.2	-	-	DUF5122,Peptidase_S74,YadA_head,YadA_stalk
HKD3_k127_6393597_3	204669.Acid345_0995	1.205e-180	572.0	COG3191@1|root,COG3191@2|Bacteria,3Y699@57723|Acidobacteria	57723|Acidobacteria	M	Peptidase family S58	-	-	3.4.11.19	ko:K01266	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S58
HKD3_k127_6393597_5	266117.Rxyl_3138	3.144e-133	434.0	COG1533@1|root,COG1533@2|Bacteria,2GM31@201174|Actinobacteria,4CQAG@84995|Rubrobacteria	84995|Rubrobacteria	L	Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
HKD3_k127_6393597_6	497964.CfE428DRAFT_6301	4.563e-122	402.0	COG0809@1|root,COG0809@2|Bacteria,46SDA@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)	queA	-	2.4.99.17	ko:K07568	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Queuosine_synth
HKD3_k127_6393597_15	1123229.AUBC01000001_gene1591	5.751e-40	153.0	COG1607@1|root,COG1607@2|Bacteria,1MZAZ@1224|Proteobacteria,2U93J@28211|Alphaproteobacteria,3JY0X@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	Thioesterase superfamily	yciA	-	-	ko:K10806	ko01040,map01040	-	-	-	ko00000,ko00001,ko01000,ko01004	-	-	-	4HBT
HKD3_k127_6393597_8	1403819.BATR01000061_gene1891	7.707e-101	342.0	COG0438@1|root,COG0438@2|Bacteria,46WHJ@74201|Verrucomicrobia,2IVEA@203494|Verrucomicrobiae	203494|Verrucomicrobiae	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
HKD3_k127_6393597_10	497964.CfE428DRAFT_3604	5.798e-76	269.0	COG3429@1|root,COG3429@2|Bacteria,46V8B@74201|Verrucomicrobia	74201|Verrucomicrobia	G	Glucose-6-phosphate dehydrogenase subunit	-	-	-	-	-	-	-	-	-	-	-	-	OpcA_G6PD_assem
HKD3_k127_6393597_0	497964.CfE428DRAFT_3605	1.511e-240	752.0	COG0364@1|root,COG0364@2|Bacteria,46SHX@74201|Verrucomicrobia	74201|Verrucomicrobia	G	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone	zwf	-	1.1.1.363,1.1.1.49	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	M00004,M00006,M00008	R00835,R02736,R10907	RC00001,RC00066	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	G6PD_C,G6PD_N
HKD3_k127_6393597_1	478741.JAFS01000001_gene2175	9.282e-206	656.0	COG0112@1|root,COG0112@2|Bacteria,46S5I@74201|Verrucomicrobia,37G4S@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	LMWPc,LacAB_rpiB,SHMT
HKD3_k127_6393597_12	497964.CfE428DRAFT_2318	2.264e-59	216.0	COG0664@1|root,COG4420@1|root,COG0664@2|Bacteria,COG4420@2|Bacteria,46T5T@74201|Verrucomicrobia	74201|Verrucomicrobia	K	Protein of unknown function (DUF1003)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1003,cNMP_binding
HKD3_k127_6393597_11	497964.CfE428DRAFT_5268	5.666e-71	251.0	COG1560@1|root,COG1560@2|Bacteria,46VIS@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Bacterial lipid A biosynthesis acyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Lip_A_acyltrans
HKD3_k127_6393597_14	1123399.AQVE01000011_gene1258	2.448e-45	180.0	COG3209@1|root,COG5295@1|root,COG3209@2|Bacteria,COG5295@2|Bacteria,1N4WT@1224|Proteobacteria	1224|Proteobacteria	UW	cellulase activity	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S74
HKD3_k127_6393597_4	216596.RL2938	4.314e-136	445.0	COG0477@1|root,COG2814@2|Bacteria,1MWKH@1224|Proteobacteria,2U1T7@28211|Alphaproteobacteria,4BAS5@82115|Rhizobiaceae	28211|Alphaproteobacteria	EGP	Sugar (and other) transporter	-	-	-	ko:K08178	-	-	-	-	ko00000,ko02000	2.A.1.12	-	-	MFS_1,Sugar_tr
HKD3_k127_6393597_13	497964.CfE428DRAFT_4528	6.085e-50	185.0	COG0860@1|root,COG0860@2|Bacteria,46VPU@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Ami_3	-	-	-	-	-	-	-	-	-	-	-	-	Amidase_3
HKD3_k127_6393597_7	497964.CfE428DRAFT_2916	8.894e-102	346.0	COG0726@1|root,COG0726@2|Bacteria,46UVJ@74201|Verrucomicrobia	74201|Verrucomicrobia	G	Polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
HKD3_k127_6393597_2	497964.CfE428DRAFT_2915	1.206e-189	601.0	COG0541@1|root,COG0541@2|Bacteria,46SIU@74201|Verrucomicrobia	74201|Verrucomicrobia	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY	ffh	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
HKD3_k127_6393597_17	497964.CfE428DRAFT_2914	8.369e-30	121.0	COG0228@1|root,COG0228@2|Bacteria,46WC2@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Belongs to the bacterial ribosomal protein bS16 family	rpsP	-	-	ko:K02959	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S16
HKD3_k127_6393597_18	497964.CfE428DRAFT_2913	9.778e-21	94.0	COG1837@1|root,COG1837@2|Bacteria	2|Bacteria	L	Belongs to the UPF0109 family	ylqC	-	-	ko:K06960	-	-	-	-	ko00000	-	-	-	KH_4
HKD3_k127_6393597_9	1396141.BATP01000034_gene4146	9.807e-94	313.0	COG0336@1|root,COG0336@2|Bacteria,46SS0@74201|Verrucomicrobia,2ITZV@203494|Verrucomicrobiae	203494|Verrucomicrobiae	J	tRNA (Guanine-1)-methyltransferase	trmD	-	2.1.1.228	ko:K00554	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	tRNA_m1G_MT
HKD3_k127_6393597_19	1408311.JNJM01000034_gene161	5.136e-12	66.0	COG0304@1|root,COG0304@2|Bacteria,1TPA7@1239|Firmicutes,247VF@186801|Clostridia,2PRVJ@265975|Oribacterium	186801|Clostridia	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	fabF	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
HKD3_k127_6401236_0	497964.CfE428DRAFT_2741	5.435e-71	243.0	COG0556@1|root,COG0556@2|Bacteria,46SF2@74201|Verrucomicrobia	74201|Verrucomicrobia	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	-	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
HKD3_k127_6401236_1	497964.CfE428DRAFT_2747	5.209e-55	199.0	COG1466@1|root,COG1466@2|Bacteria,46T5Y@74201|Verrucomicrobia	74201|Verrucomicrobia	L	DNA polymerase III, delta subunit	holA	-	2.7.7.7	ko:K02340	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta
HKD3_k127_6424354_11	497964.CfE428DRAFT_3303	1.696e-25	107.0	COG0504@1|root,COG0504@2|Bacteria,46S8K@74201|Verrucomicrobia	74201|Verrucomicrobia	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_synth_N,GATase
HKD3_k127_6424354_7	240016.ABIZ01000001_gene5173	2.577e-95	323.0	COG0009@1|root,COG0009@2|Bacteria,46SUC@74201|Verrucomicrobia,2ITRQ@203494|Verrucomicrobiae	203494|Verrucomicrobiae	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine	-	-	2.7.7.87	ko:K07566	-	-	R10463	RC00745	ko00000,ko01000,ko03009,ko03016	-	-	-	SUA5,Sua5_yciO_yrdC
HKD3_k127_6424354_8	497964.CfE428DRAFT_4023	7.746e-59	208.0	COG0041@1|root,COG0041@2|Bacteria,46SRV@74201|Verrucomicrobia	74201|Verrucomicrobia	F	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)	purE	-	5.4.99.18	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07405	RC01947	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRC
HKD3_k127_6424354_10	1396418.BATQ01000171_gene2946	1.98e-36	145.0	COG0451@1|root,COG0703@1|root,COG0451@2|Bacteria,COG0703@2|Bacteria,46SWG@74201|Verrucomicrobia,2IUD4@203494|Verrucomicrobiae	203494|Verrucomicrobiae	GM	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase,SKI
HKD3_k127_6424354_3	497964.CfE428DRAFT_4021	2.598e-139	451.0	COG1600@1|root,COG1600@2|Bacteria,46SDV@74201|Verrucomicrobia	74201|Verrucomicrobia	C	Domain of unknown function (DUF1730)	-	-	1.17.99.6	ko:K18979	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DUF1730,Fer4_16
HKD3_k127_6424354_5	452637.Oter_1637	1.682e-129	428.0	COG0845@1|root,COG0845@2|Bacteria,46SKN@74201|Verrucomicrobia,3K76J@414999|Opitutae	414999|Opitutae	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	HlyD_D23
HKD3_k127_6424354_12	880072.Desac_2180	6.612e-14	76.0	COG0399@1|root,COG0399@2|Bacteria,1N0QW@1224|Proteobacteria,42W70@68525|delta/epsilon subdivisions,2WRUT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	PFAM S23 ribosomal protein	-	-	-	-	-	-	-	-	-	-	-	-	23S_rRNA_IVP
HKD3_k127_6424354_6	278957.ABEA03000126_gene3673	2.955e-108	355.0	COG1136@1|root,COG1136@2|Bacteria,46SI5@74201|Verrucomicrobia,3K7NZ@414999|Opitutae	414999|Opitutae	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD3_k127_6424354_0	1519464.HY22_00710	1.169e-167	536.0	COG0577@1|root,COG0577@2|Bacteria,1FDSK@1090|Chlorobi	1090|Chlorobi	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HKD3_k127_6424354_1	1519464.HY22_00720	3.169e-158	509.0	COG0577@1|root,COG0577@2|Bacteria,1FDBN@1090|Chlorobi	1090|Chlorobi	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HKD3_k127_6424354_2	497964.CfE428DRAFT_4774	1.063e-145	468.0	COG0714@1|root,COG0714@2|Bacteria,46SKP@74201|Verrucomicrobia	74201|Verrucomicrobia	S	PFAM ATPase associated with various cellular activities AAA_3	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
HKD3_k127_6424354_9	497964.CfE428DRAFT_4775	3.407e-54	201.0	COG1721@1|root,COG1721@2|Bacteria	2|Bacteria	E	protein (some members contain a von Willebrand factor type A (vWA) domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
HKD3_k127_6424354_4	497964.CfE428DRAFT_4776	4.514e-136	457.0	COG1305@1|root,COG1305@2|Bacteria	2|Bacteria	E	Transglutaminase-like superfamily	tgpA	-	2.3.2.13	ko:K22452	-	-	-	-	ko00000,ko01000	-	-	-	DUF3488,DUF4129,Transglut_core
HKD3_k127_6426187_0	1047013.AQSP01000075_gene1424	1.164e-224	715.0	COG0793@1|root,COG4946@1|root,COG0793@2|Bacteria,COG4946@2|Bacteria,2NQEH@2323|unclassified Bacteria	2|Bacteria	M	Tricorn protease C1 domain	-	-	-	ko:K08676	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PD40,Peptidase_S41,Tricorn_C1,Tricorn_PDZ
HKD3_k127_6426187_1	497964.CfE428DRAFT_1973	4.1e-85	289.0	COG1488@1|root,COG1488@2|Bacteria,46SAG@74201|Verrucomicrobia	74201|Verrucomicrobia	H	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP	pncB	-	6.3.4.21	ko:K00763	ko00760,ko01100,map00760,map01100	-	R01724	RC00033	ko00000,ko00001,ko01000	-	-	-	NAPRTase
HKD3_k127_64711_5	859657.RPSI07_2262	4.9e-26	110.0	COG1146@1|root,COG1146@2|Bacteria,1RH5I@1224|Proteobacteria,2VSJ0@28216|Betaproteobacteria,1K7UM@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions	fdxA	-	-	ko:K05524	-	-	-	-	ko00000	-	-	-	DUF3470,Fer4,Fer4_4
HKD3_k127_64711_9	331869.BAL199_06988	0.00073	44.0	COG3791@1|root,COG3791@2|Bacteria,1RCYS@1224|Proteobacteria,2U5UG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Glutathione-dependent formaldehyde-activating enzyme	MA20_19505	-	-	-	-	-	-	-	-	-	-	-	GFA
HKD3_k127_64711_8	1267005.KB911260_gene3565	2.358e-05	49.0	COG3791@1|root,COG3791@2|Bacteria	2|Bacteria	S	Glutathione-dependent formaldehyde-activating	-	-	-	-	-	-	-	-	-	-	-	-	GFA
HKD3_k127_64711_7	331869.BAL199_06988	6.252e-20	91.0	COG3791@1|root,COG3791@2|Bacteria,1RCYS@1224|Proteobacteria,2U5UG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Glutathione-dependent formaldehyde-activating enzyme	MA20_19505	-	-	-	-	-	-	-	-	-	-	-	GFA
HKD3_k127_64711_1	497964.CfE428DRAFT_5191	3.606e-287	888.0	COG0459@1|root,COG0459@2|Bacteria,46S9U@74201|Verrucomicrobia	74201|Verrucomicrobia	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	-	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
HKD3_k127_64711_4	497964.CfE428DRAFT_5190	3.921e-41	153.0	COG0234@1|root,COG0234@2|Bacteria,46SZ8@74201|Verrucomicrobia	74201|Verrucomicrobia	O	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter	groS	-	-	ko:K04078	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Cpn10
HKD3_k127_64711_0	497964.CfE428DRAFT_5188	0.0	1079.0	COG0443@1|root,COG0443@2|Bacteria,46SDM@74201|Verrucomicrobia	74201|Verrucomicrobia	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
HKD3_k127_64711_3	497964.CfE428DRAFT_3384	2.087e-133	429.0	COG0207@1|root,COG0207@2|Bacteria,46SCY@74201|Verrucomicrobia	74201|Verrucomicrobia	F	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis	thyA	-	2.1.1.45	ko:K00560	ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523	M00053	R02101	RC00219,RC00332	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylat_synt
HKD3_k127_64711_2	497964.CfE428DRAFT_4581	4.665e-245	777.0	COG0793@1|root,COG0793@2|Bacteria,46S88@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Belongs to the peptidase S41A family	prc	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	DUF3340,PDZ,Peptidase_S41
HKD3_k127_64711_6	497964.CfE428DRAFT_4580	1.028e-21	98.0	COG0491@1|root,COG0491@2|Bacteria,46T2E@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HKD3_k127_6478324_1	497964.CfE428DRAFT_4379	2.918e-38	147.0	COG1664@1|root,COG1664@2|Bacteria,46VS6@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Polymer-forming cytoskeletal	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
HKD3_k127_6478324_3	575540.Isop_1665	3.683e-19	97.0	COG2834@1|root,COG2834@2|Bacteria	2|Bacteria	M	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4292
HKD3_k127_6478324_2	1166018.FAES_5157	9.749e-29	132.0	COG1807@1|root,COG1807@2|Bacteria	2|Bacteria	M	4-amino-4-deoxy-L-arabinose transferase activity	-	-	-	ko:K14340	-	-	-	-	ko00000,ko01000,ko01003	-	-	-	PMT_2
HKD3_k127_6478324_0	1116472.MGMO_20c00060	1.353e-54	194.0	2D8VC@1|root,32TS1@2|Bacteria,1MZWT@1224|Proteobacteria,1T747@1236|Gammaproteobacteria,1XGP9@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_6480417_1	426117.M446_0945	1.102e-07	64.0	COG2246@1|root,COG2246@2|Bacteria,1QXD1@1224|Proteobacteria	1224|Proteobacteria	S	polysaccharide biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_6480417_0	497964.CfE428DRAFT_6471	7.039e-131	429.0	COG0508@1|root,COG0508@2|Bacteria,46UHU@74201|Verrucomicrobia	74201|Verrucomicrobia	C	2-oxoacid dehydrogenases acyltransferase (catalytic domain)	-	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
HKD3_k127_6524492_0	497964.CfE428DRAFT_4653	3.639e-211	667.0	COG1199@1|root,COG1199@2|Bacteria,46SCS@74201|Verrucomicrobia	74201|Verrucomicrobia	L	SMART helicase c2	dinG	-	3.6.4.12	ko:K03722	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_2,Helicase_C_2,ResIII
HKD3_k127_6590664_1	1396418.BATQ01000047_gene6209	5.669e-204	649.0	COG2804@1|root,COG2804@2|Bacteria,46SDR@74201|Verrucomicrobia,2IU2P@203494|Verrucomicrobiae	203494|Verrucomicrobiae	NU	Type II/IV secretion system protein	-	-	-	ko:K02652	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE,T2SSE_N
HKD3_k127_6590664_0	497964.CfE428DRAFT_1455	3.776e-262	817.0	COG2804@1|root,COG2804@2|Bacteria,46UFR@74201|Verrucomicrobia	74201|Verrucomicrobia	NU	type II secretion system protein E	-	-	-	ko:K02652	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE,T2SSE_N
HKD3_k127_6590664_2	497964.CfE428DRAFT_1451	1.104e-165	531.0	COG1459@1|root,COG1459@2|Bacteria,46S8P@74201|Verrucomicrobia	74201|Verrucomicrobia	NU	type II secretion	-	-	-	ko:K02653	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSF
HKD3_k127_6710676_8	1123070.KB899259_gene1974	1.48e-117	400.0	COG3276@1|root,COG3276@2|Bacteria	2|Bacteria	J	selenocysteine insertion sequence binding	selB	GO:0000049,GO:0000166,GO:0001514,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006412,GO:0006414,GO:0006417,GO:0006451,GO:0006518,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009069,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010608,GO:0016259,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019003,GO:0019222,GO:0019538,GO:0019752,GO:0031323,GO:0031326,GO:0032268,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034248,GO:0034641,GO:0034645,GO:0035368,GO:0035639,GO:0036094,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051246,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:2000112	-	ko:K03833	-	-	-	-	ko00000,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,SelB-wing_2,SelB-wing_3
HKD3_k127_6710676_0	497964.CfE428DRAFT_0920	1.043e-269	865.0	COG1074@1|root,COG1074@2|Bacteria	2|Bacteria	L	ATP-dependent DNA helicase activity	recB	-	3.6.4.12	ko:K16898	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	AAA_19,DUF3799,NERD,PDDEXK_1,UvrD-helicase,UvrD_C
HKD3_k127_6710676_3	1094980.Mpsy_2024	3.802e-169	539.0	COG1260@1|root,arCOG04213@2157|Archaea,2XVGK@28890|Euryarchaeota,2N96M@224756|Methanomicrobia	224756|Methanomicrobia	I	Myo-inositol-1-phosphate synthase	-	-	5.5.1.4	ko:K01858	ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130	-	R07324	RC01804	ko00000,ko00001,ko01000	-	-	-	Inos-1-P_synth
HKD3_k127_6710676_26	452637.Oter_3801	1.39e-40	168.0	COG1538@1|root,COG1538@2|Bacteria,46T0P@74201|Verrucomicrobia,3K73I@414999|Opitutae	414999|Opitutae	MU	PFAM outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
HKD3_k127_6710676_37	880073.Calab_2440	8.276e-05	55.0	COG1538@1|root,COG1538@2|Bacteria,2NPKK@2323|unclassified Bacteria	2|Bacteria	MU	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
HKD3_k127_6710676_32	1167006.UWK_03445	1.641e-14	86.0	COG0845@1|root,COG0845@2|Bacteria,1MUMV@1224|Proteobacteria,42PK1@68525|delta/epsilon subdivisions,2WJ65@28221|Deltaproteobacteria,2MPVI@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_D23
HKD3_k127_6710676_16	794903.OPIT5_28845	4.561e-86	301.0	COG4591@1|root,COG4591@2|Bacteria,46UC8@74201|Verrucomicrobia,3K7GQ@414999|Opitutae	414999|Opitutae	M	MacB-like periplasmic core domain	-	-	-	ko:K09808	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.125	-	-	FtsX,MacB_PCD
HKD3_k127_6710676_17	452637.Oter_3937	3.931e-78	268.0	COG1136@1|root,COG1136@2|Bacteria,46UT0@74201|Verrucomicrobia,3K7YN@414999|Opitutae	414999|Opitutae	P	ATPases associated with a variety of cellular activities	-	-	-	ko:K09810	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.125	-	-	ABC_tran
HKD3_k127_6710676_29	335543.Sfum_2923	2.042e-29	133.0	COG0558@1|root,COG0558@2|Bacteria,1MYE7@1224|Proteobacteria,43F1I@68525|delta/epsilon subdivisions,2WXQ5@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	-	-	-	-	-	-	-	-	-	-	-	-	CDP-OH_P_transf
HKD3_k127_6710676_28	272568.GDI0501	8.679e-31	136.0	COG0535@1|root,COG0535@2|Bacteria,1Q8U2@1224|Proteobacteria,2UYJA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	4Fe-4S single cluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM
HKD3_k127_6710676_35	558173.CDOO_05730	2.409e-05	48.0	COG0477@1|root,COG2814@2|Bacteria,2GK1K@201174|Actinobacteria,22JJ8@1653|Corynebacteriaceae	201174|Actinobacteria	EGP	Major Facilitator	blt	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
HKD3_k127_6710676_22	666685.R2APBS1_1456	1.012e-43	176.0	COG2120@1|root,COG2120@2|Bacteria,1PGKP@1224|Proteobacteria,1RXHM@1236|Gammaproteobacteria,1X6FI@135614|Xanthomonadales	135614|Xanthomonadales	S	GlcNAc-PI de-N-acetylase	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
HKD3_k127_6710676_7	1123242.JH636437_gene6037	4.973e-120	400.0	COG1287@1|root,COG1287@2|Bacteria	2|Bacteria	S	oligosaccharyl transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	GT87,PMT_2
HKD3_k127_6710676_18	1192034.CAP_2776	2.102e-72	258.0	COG0438@1|root,COG0438@2|Bacteria,1N9EV@1224|Proteobacteria,42PK2@68525|delta/epsilon subdivisions,2WP9Y@28221|Deltaproteobacteria,2YW87@29|Myxococcales	28221|Deltaproteobacteria	M	Glycosyl transferases group 1	-	-	2.4.1.349	ko:K12994	-	-	-	-	ko00000,ko01000,ko01003,ko01005	-	GT4	-	Glyco_transf_4,Glycos_transf_1
HKD3_k127_6710676_11	497964.CfE428DRAFT_4057	1.433e-100	350.0	COG1807@1|root,COG1807@2|Bacteria	2|Bacteria	M	4-amino-4-deoxy-L-arabinose transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	PMT,PMT_2
HKD3_k127_6710676_27	1123322.KB904658_gene1187	4.825e-31	139.0	COG1807@1|root,COG1807@2|Bacteria,2GP96@201174|Actinobacteria	201174|Actinobacteria	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HKD3_k127_6710676_13	1316936.K678_14714	3.865e-93	321.0	COG0859@1|root,COG0859@2|Bacteria,1PQIJ@1224|Proteobacteria,2V2XG@28211|Alphaproteobacteria,2JW5Y@204441|Rhodospirillales	204441|Rhodospirillales	M	Glycosyltransferase family 9 (heptosyltransferase)	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_9
HKD3_k127_6710676_34	47763.JNZA01000012_gene6572	3.495e-12	79.0	COG2244@1|root,COG2244@2|Bacteria,2I4II@201174|Actinobacteria	201174|Actinobacteria	Q	Membrane protein involved in the export of O-antigen and teichoic acid	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt,Polysacc_synt_C
HKD3_k127_6710676_30	177437.HRM2_42480	2.36e-29	123.0	COG0463@1|root,COG0463@2|Bacteria,1PWY6@1224|Proteobacteria,438K6@68525|delta/epsilon subdivisions,2WY00@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Glycosyl transferase, family 2	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_6710676_33	351160.RCIX211	1.305e-13	84.0	COG1807@1|root,arCOG03981@1|root,arCOG00566@2157|Archaea,arCOG03981@2157|Archaea,2Y4H0@28890|Euryarchaeota	28890|Euryarchaeota	M	Protein of unknown function (DUF2723)	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HKD3_k127_6710676_12	497964.CfE428DRAFT_2977	3.103e-94	331.0	COG1807@1|root,COG1807@2|Bacteria	2|Bacteria	M	4-amino-4-deoxy-L-arabinose transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HKD3_k127_6710676_25	452637.Oter_4014	3.778e-42	165.0	COG0300@1|root,COG0300@2|Bacteria,46VV4@74201|Verrucomicrobia,3K7WJ@414999|Opitutae	414999|Opitutae	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HKD3_k127_6710676_24	518766.Rmar_1196	2.249e-43	170.0	COG1213@1|root,COG1213@2|Bacteria,4P23X@976|Bacteroidetes	976|Bacteroidetes	M	Nucleotidyl transferase	-	-	2.7.7.74	ko:K07281	ko00562,map00562	-	R09669	RC00002	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
HKD3_k127_6710676_31	944480.ATUV01000002_gene132	7.035e-15	83.0	COG0558@1|root,COG1213@1|root,COG0558@2|Bacteria,COG1213@2|Bacteria,1NN43@1224|Proteobacteria,432HN@68525|delta/epsilon subdivisions,2WYCV@28221|Deltaproteobacteria,2M7MC@213113|Desulfurellales	28221|Deltaproteobacteria	IM	CDP-alcohol phosphatidyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	CDP-OH_P_transf
HKD3_k127_6710676_10	1297742.A176_03127	8.886e-113	376.0	COG0454@1|root,COG0456@2|Bacteria,1PMA3@1224|Proteobacteria,42PYX@68525|delta/epsilon subdivisions,2WKSE@28221|Deltaproteobacteria,2YUVH@29|Myxococcales	28221|Deltaproteobacteria	K	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_6710676_21	743722.Sph21_2689	5.791e-63	228.0	COG0558@1|root,COG0558@2|Bacteria,4NFW0@976|Bacteroidetes,1IU96@117747|Sphingobacteriia	976|Bacteroidetes	I	CDP-alcohol phosphatidyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	CDP-OH_P_transf
HKD3_k127_6710676_5	391625.PPSIR1_34372	8.966e-142	462.0	COG0156@1|root,COG0156@2|Bacteria,1MVVH@1224|Proteobacteria,42MM1@68525|delta/epsilon subdivisions,2WIU7@28221|Deltaproteobacteria,2YX7Y@29|Myxococcales	28221|Deltaproteobacteria	E	Beta-eliminating lyase	bioF1	-	2.3.1.29,2.3.1.47	ko:K00639,ko:K00652	ko00260,ko00780,ko01100,map00260,map00780,map01100	M00123,M00573,M00577	R00371,R03210,R10124	RC00004,RC00039,RC00394,RC02725	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
HKD3_k127_6710676_19	1519464.HY22_11180	1.578e-69	241.0	COG3000@1|root,COG3000@2|Bacteria	2|Bacteria	I	iron ion binding	-	-	-	-	-	-	-	-	-	-	-	-	FA_hydroxylase
HKD3_k127_6710676_6	883078.HMPREF9695_00530	1.886e-127	415.0	COG3239@1|root,COG3239@2|Bacteria,1NS28@1224|Proteobacteria,2TRD0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Sphingolipid Delta4-desaturase (DES)	-	-	1.14.18.5,1.14.19.17	ko:K04712	ko00600,ko01100,ko04071,map00600,map01100,map04071	M00094,M00099	R06519	RC00824	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FA_desaturase,Lipid_DES
HKD3_k127_6710676_36	1089439.KB902251_gene1515	6.125e-05	48.0	2DTNT@1|root,33M3P@2|Bacteria,1NH3S@1224|Proteobacteria,1SGZB@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_6710676_9	497964.CfE428DRAFT_3169	4.414e-113	380.0	COG1519@1|root,COG1519@2|Bacteria,46SK9@74201|Verrucomicrobia	74201|Verrucomicrobia	M	PFAM Three-deoxy-D-manno-octulosonic-acid transferase domain protein	kdtA	-	2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15	ko:K02527	ko00540,ko01100,map00540,map01100	M00060,M00080	R04658,R05074,R09763	RC00009,RC00077,RC00247	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT30	-	Glycos_transf_1,Glycos_transf_N
HKD3_k127_6710676_23	240016.ABIZ01000001_gene4602	1.799e-43	165.0	COG0742@1|root,COG0742@2|Bacteria,46T62@74201|Verrucomicrobia,2IUEM@203494|Verrucomicrobiae	203494|Verrucomicrobiae	L	Conserved hypothetical protein 95	-	-	-	-	-	-	-	-	-	-	-	-	Cons_hypoth95
HKD3_k127_6710676_20	497964.CfE428DRAFT_3167	1.258e-67	250.0	COG2982@1|root,COG2982@2|Bacteria	2|Bacteria	M	Protein involved in outer membrane biogenesis	-	-	-	ko:K07290	-	-	-	-	ko00000	9.B.121	-	-	AsmA,AsmA_2,DUF3971,DUF748
HKD3_k127_6710676_15	497964.CfE428DRAFT_3166	3.122e-88	299.0	COG1597@1|root,COG1597@2|Bacteria,46SR5@74201|Verrucomicrobia	74201|Verrucomicrobia	I	Diacylglycerol kinase	-	-	-	-	-	-	-	-	-	-	-	-	DAGK_cat
HKD3_k127_6710676_4	478741.JAFS01000001_gene1793	8.54e-153	516.0	COG1391@1|root,COG1391@2|Bacteria,46YXF@74201|Verrucomicrobia,37GG6@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	H	Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell	glnE	-	2.7.7.42,2.7.7.89	ko:K00982	-	-	-	-	ko00000,ko01000	-	-	-	GlnD_UR_UTase,GlnE
HKD3_k127_6710676_2	497964.CfE428DRAFT_0213	3.129e-176	563.0	COG1158@1|root,COG1158@2|Bacteria,46UQY@74201|Verrucomicrobia	74201|Verrucomicrobia	K	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template	-	-	-	ko:K03628	ko03018,map03018	-	-	-	ko00000,ko00001,ko03019,ko03021	-	-	-	ATP-synt_ab,Rho_RNA_bind
HKD3_k127_6710676_14	497964.CfE428DRAFT_0212	1.747e-91	306.0	COG0217@1|root,COG0217@2|Bacteria,46SP3@74201|Verrucomicrobia	74201|Verrucomicrobia	K	transcriptional regulatory protein	-	-	-	-	-	-	-	-	-	-	-	-	Transcrip_reg
HKD3_k127_6727572_7	497964.CfE428DRAFT_4125	2.482e-63	231.0	COG0515@1|root,COG0790@1|root,COG0515@2|Bacteria,COG0790@2|Bacteria	2|Bacteria	S	beta-lactamase activity	-	-	-	ko:K07126	-	-	-	-	ko00000	-	-	-	Sel1,WG_beta_rep
HKD3_k127_6727572_12	234267.Acid_7851	2.118e-12	71.0	COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,3Y6UN@57723|Acidobacteria	57723|Acidobacteria	K	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_6727572_5	1122604.JONR01000031_gene1279	2.122e-78	282.0	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1T5SE@1236|Gammaproteobacteria,1XDE6@135614|Xanthomonadales	135614|Xanthomonadales	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_19
HKD3_k127_6727572_13	1122604.JONR01000004_gene851	3.206e-11	72.0	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1T234@1236|Gammaproteobacteria,1X903@135614|Xanthomonadales	135614|Xanthomonadales	S	Adenylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16
HKD3_k127_6727572_9	404589.Anae109_1057	6.386e-32	125.0	COG0346@1|root,COG0346@2|Bacteria,1MV4D@1224|Proteobacteria	1224|Proteobacteria	E	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HKD3_k127_6727572_0	765952.PUV_12850	0.0	2792.0	COG3459@1|root,COG3459@2|Bacteria	2|Bacteria	G	carbohydrate binding	ndvB	-	-	ko:K13688	-	-	-	-	ko00000,ko01000,ko01003	-	GH94,GT84	-	DUF3131,Glyco_hydro_36,Glyco_transf_36,Glycoamylase
HKD3_k127_6727572_11	497964.CfE428DRAFT_4858	1.012e-24	106.0	COG0724@1|root,COG0724@2|Bacteria,46VMU@74201|Verrucomicrobia	74201|Verrucomicrobia	S	PFAM RNP-1 like RNA-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	RRM_1
HKD3_k127_6727572_6	1192034.CAP_4903	9.777e-71	267.0	COG3055@1|root,COG3055@2|Bacteria	2|Bacteria	G	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses	-	-	-	-	-	-	-	-	-	-	-	-	Kelch_4
HKD3_k127_6727572_3	1210884.HG799467_gene13285	5.043e-113	376.0	COG1363@1|root,COG1363@2|Bacteria,2IXMY@203682|Planctomycetes	203682|Planctomycetes	G	COG1363 Cellulase M and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M42
HKD3_k127_6727572_10	710421.Mycch_5258	3.808e-29	129.0	COG0500@1|root,COG2226@2|Bacteria,2GNXF@201174|Actinobacteria,23B3U@1762|Mycobacteriaceae	201174|Actinobacteria	Q	Methyltransferase domain	-	-	2.1.1.288	ko:K15942	ko01057,ko01130,map01057,map01130	M00781	R06675,R06680	RC00003,RC00460	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_11,Methyltransf_25,Methyltransf_31
HKD3_k127_6727572_8	234267.Acid_4411	2.653e-46	168.0	COG0640@1|root,COG0640@2|Bacteria,3Y5ZP@57723|Acidobacteria	57723|Acidobacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
HKD3_k127_6727572_2	234267.Acid_4410	5.437e-123	399.0	COG0500@1|root,COG2226@2|Bacteria,3Y4HC@57723|Acidobacteria	57723|Acidobacteria	Q	Hypothetical methyltransferase	-	-	2.1.1.137	ko:K07755	-	-	-	-	ko00000,ko01000	-	-	-	Methyltransf_31
HKD3_k127_6727572_4	1463895.JODA01000010_gene7076	1.969e-81	281.0	COG0596@1|root,COG0596@2|Bacteria,2IAVM@201174|Actinobacteria	201174|Actinobacteria	S	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6,Hydrolase_4
HKD3_k127_6727572_1	479431.Namu_0377	1.848e-125	415.0	COG0739@1|root,COG0739@2|Bacteria,2I9IY@201174|Actinobacteria,4EWJG@85013|Frankiales	201174|Actinobacteria	M	PFAM Peptidase M23	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
HKD3_k127_6727572_15	319003.Bra1253DRAFT_05341	0.0001368	47.0	COG2159@1|root,COG2159@2|Bacteria,1QUT5@1224|Proteobacteria	1224|Proteobacteria	S	AIPR protein	-	-	-	-	-	-	-	-	-	-	-	-	AIPR
HKD3_k127_6727572_14	240016.ABIZ01000001_gene1407	2.448e-05	56.0	2E3AC@1|root,32Y9V@2|Bacteria	2|Bacteria	S	Putative peptidoglycan binding domain	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_1
HKD3_k127_6750943_1	497964.CfE428DRAFT_0215	6.638e-27	114.0	COG1716@1|root,COG2114@1|root,COG1716@2|Bacteria,COG2114@2|Bacteria	2|Bacteria	T	Pfam Adenylate and Guanylate cyclase catalytic domain	cya1	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	FHA,Guanylate_cyc
HKD3_k127_6750943_0	1403819.BATR01000051_gene1473	1.39e-93	316.0	COG0515@1|root,COG0515@2|Bacteria,46UMT@74201|Verrucomicrobia,2IVH7@203494|Verrucomicrobiae	203494|Verrucomicrobiae	KLT	Protein tyrosine kinase	-	-	-	-	-	-	-	-	-	-	-	-	PEGA,PG_binding_1,Pkinase
HKD3_k127_6782701_3	497964.CfE428DRAFT_2416	2.832e-06	49.0	COG1943@1|root,COG1943@2|Bacteria,46VNW@74201|Verrucomicrobia	74201|Verrucomicrobia	L	Transposase IS200 like	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
HKD3_k127_6782701_0	1246474.ANBE01000012_gene3752	8.957e-75	259.0	COG1526@1|root,COG1526@2|Bacteria,2GKWC@201174|Actinobacteria,4EFG2@85012|Streptosporangiales	201174|Actinobacteria	C	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH	fdhD	-	-	ko:K02379	-	-	-	-	ko00000	-	-	-	FdhD-NarQ
HKD3_k127_6782701_1	497964.CfE428DRAFT_0298	1.944e-56	202.0	COG2258@1|root,COG2258@2|Bacteria,46VBP@74201|Verrucomicrobia	74201|Verrucomicrobia	S	MOSC domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_6782701_2	497964.CfE428DRAFT_0299	2.08e-27	117.0	COG0746@1|root,COG0746@2|Bacteria,46T8C@74201|Verrucomicrobia	74201|Verrucomicrobia	H	MobA-like NTP transferase domain	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_3
HKD3_k127_6834583_7	857087.Metme_1559	1.686e-128	419.0	COG4974@1|root,COG4974@2|Bacteria,1MVAN@1224|Proteobacteria,1RMSS@1236|Gammaproteobacteria,1XE2N@135618|Methylococcales	135618|Methylococcales	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_4,Phage_integrase
HKD3_k127_6834583_0	497964.CfE428DRAFT_3887	0.0	1129.0	COG0726@1|root,COG1215@1|root,COG3858@1|root,COG0726@2|Bacteria,COG1215@2|Bacteria,COG3858@2|Bacteria,46VK0@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Glycosyl transferase family 21	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3
HKD3_k127_6834583_10	497964.CfE428DRAFT_0226	1.495e-63	226.0	COG0663@1|root,COG0663@2|Bacteria	2|Bacteria	G	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep
HKD3_k127_6834583_9	497964.CfE428DRAFT_0543	8.144e-95	325.0	COG1929@1|root,COG1929@2|Bacteria	2|Bacteria	G	organic acid phosphorylation	glxK	-	2.7.1.165	ko:K00865	ko00260,ko00561,ko00630,ko01100,ko01120,ko01130,map00260,map00561,map00630,map01100,map01120,map01130	-	R08572	RC00002,RC00428	ko00000,ko00001,ko01000	-	-	-	Gly_kinase
HKD3_k127_6834583_4	1403819.BATR01000031_gene1031	4.009e-194	616.0	COG0064@1|root,COG0064@2|Bacteria,46S5X@74201|Verrucomicrobia,2ITJA@203494|Verrucomicrobiae	203494|Verrucomicrobiae	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatB	-	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	GatB_N,GatB_Yqey
HKD3_k127_6834583_6	1173263.Syn7502_00999	7.43e-163	522.0	COG0082@1|root,COG0082@2|Bacteria,1G12S@1117|Cyanobacteria,1GYWY@1129|Synechococcus	1117|Cyanobacteria	E	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system	aroC	GO:0000166,GO:0003674,GO:0003824,GO:0004107,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0010181,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0032553,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050662,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	4.2.3.5	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01714	RC00586	ko00000,ko00001,ko00002,ko01000	-	-	iJN678.aroC	Chorismate_synt
HKD3_k127_6834583_5	1183438.GKIL_3015	2.224e-183	580.0	COG0626@1|root,COG0626@2|Bacteria,1G43Q@1117|Cyanobacteria	1117|Cyanobacteria	E	cystathionine	metB	-	2.5.1.48,4.4.1.1	ko:K01739,ko:K01758	ko00260,ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00260,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017,M00338	R00782,R00999,R01001,R01288,R02408,R02508,R03217,R03260,R04770,R04930,R04944,R04945,R04946,R09366	RC00020,RC00056,RC00069,RC00348,RC00382,RC00420,RC00710,RC01209,RC01210,RC01245,RC02303,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Cys_Met_Meta_PP
HKD3_k127_6834583_3	1183438.GKIL_3014	6.705e-205	647.0	COG0031@1|root,COG0031@2|Bacteria,1G0T4@1117|Cyanobacteria	1117|Cyanobacteria	E	cysteine synthase	-	-	4.2.1.22	ko:K01697	ko00260,ko00270,ko01100,ko01130,ko01230,map00260,map00270,map01100,map01130,map01230	M00035,M00338	R00891,R01290,R04942	RC00056,RC00069,RC00256,RC00489,RC01246	ko00000,ko00001,ko00002,ko01000	-	-	-	CBS,PALP
HKD3_k127_6834583_11	452637.Oter_1509	1.498e-39	153.0	COG0526@1|root,COG0526@2|Bacteria	2|Bacteria	CO	cell redox homeostasis	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,Redoxin,Thioredoxin,Thioredoxin_8
HKD3_k127_6834583_1	497964.CfE428DRAFT_3359	7.3e-295	913.0	COG0539@1|root,COG0539@2|Bacteria,46SFY@74201|Verrucomicrobia	74201|Verrucomicrobia	J	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence	-	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
HKD3_k127_6834583_12	357808.RoseRS_0779	8.431e-33	147.0	COG1807@1|root,COG1807@2|Bacteria,2G8TF@200795|Chloroflexi,377RQ@32061|Chloroflexia	32061|Chloroflexia	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HKD3_k127_6834583_8	234267.Acid_7851	8.637e-126	428.0	COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,3Y6UN@57723|Acidobacteria	57723|Acidobacteria	K	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_6834583_2	452637.Oter_3724	2.376e-217	677.0	COG0017@1|root,COG0017@2|Bacteria	2|Bacteria	J	Asparaginyl-tRNA synthetase	asnS	GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004816,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006421,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.1.1.22	ko:K01893	ko00970,map00970	M00359,M00360	R03648	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iSDY_1059.SDY_2327	tRNA-synt_2,tRNA_anti-codon
HKD3_k127_6864914_0	497964.CfE428DRAFT_2487	3.246e-148	484.0	28HQ3@1|root,2Z7XW@2|Bacteria,46U81@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Protein of unknown function (DUF2851)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2851
HKD3_k127_6864914_1	497964.CfE428DRAFT_4099	3.212e-93	317.0	28JRZ@1|root,2Z9HI@2|Bacteria,46TRU@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Domain of unknown function (DUF4126)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4126
HKD3_k127_6911776_2	497964.CfE428DRAFT_1457	3.454e-36	141.0	COG2804@1|root,COG2804@2|Bacteria,46SDR@74201|Verrucomicrobia	74201|Verrucomicrobia	NU	General secretory system II protein E domain protein	pulE	-	-	ko:K02454,ko:K02652	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15,3.A.15.2	-	-	T2SSE,T2SSE_N
HKD3_k127_6911776_3	1156937.MFUM_290019	3.175e-05	51.0	COG2220@1|root,COG2220@2|Bacteria,46ZEV@74201|Verrucomicrobia,37GY0@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_3
HKD3_k127_6911776_0	497964.CfE428DRAFT_1082	1.351e-251	787.0	COG1222@1|root,COG1222@2|Bacteria,46UBC@74201|Verrucomicrobia	74201|Verrucomicrobia	O	Proteasomal ATPase OB/ID domain	-	-	-	ko:K13527	ko03050,map03050	M00342	-	-	ko00000,ko00001,ko00002,ko03051	-	-	-	AAA,Prot_ATP_ID_OB
HKD3_k127_6911776_1	497964.CfE428DRAFT_4751	1.249e-174	552.0	COG4122@1|root,COG4122@2|Bacteria,46TEU@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Pup-ligase protein	-	-	3.5.1.119	ko:K20814	-	-	-	-	ko00000,ko01000,ko03051	-	-	-	Pup_ligase
HKD3_k127_7044237_1	497964.CfE428DRAFT_4864	2.371e-57	209.0	COG1595@1|root,COG1595@2|Bacteria,46VE8@74201|Verrucomicrobia	74201|Verrucomicrobia	K	DNA-templated transcription, initiation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_7044237_0	323261.Noc_1229	4.703e-68	239.0	COG0457@1|root,COG0457@2|Bacteria,1QW39@1224|Proteobacteria,1S9J6@1236|Gammaproteobacteria,1X1GX@135613|Chromatiales	135613|Chromatiales	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_2
HKD3_k127_7044237_2	583355.Caka_1992	1.389e-50	186.0	COG1943@1|root,COG1943@2|Bacteria	2|Bacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_2
HKD3_k127_7044237_3	497964.CfE428DRAFT_4166	9.913e-30	122.0	COG0215@1|root,COG0215@2|Bacteria,46SES@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	-	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e
HKD3_k127_7251774_2	1396141.BATP01000007_gene5544	2.516e-23	100.0	2E3V1@1|root,32YSA@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_7251774_3	1211815.CBYP010000013_gene3571	4.816e-08	58.0	2DIJW@1|root,303H5@2|Bacteria,2HD0U@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_7251774_1	1380390.JIAT01000011_gene2465	2.377e-45	169.0	COG3791@1|root,COG3791@2|Bacteria,2HQXY@201174|Actinobacteria,4CSQD@84995|Rubrobacteria	84995|Rubrobacteria	S	Glutathione-dependent formaldehyde-activating enzyme	-	-	-	-	-	-	-	-	-	-	-	-	GFA
HKD3_k127_7251774_0	1267533.KB906734_gene4062	9.959e-114	368.0	COG0499@1|root,COG0499@2|Bacteria,3Y2J2@57723|Acidobacteria,2JIFV@204432|Acidobacteriia	204432|Acidobacteriia	H	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine	ahcY	-	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
HKD3_k127_7256505_0	234267.Acid_7851	1.114e-136	460.0	COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,3Y6UN@57723|Acidobacteria	57723|Acidobacteria	K	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_7261023_28	221288.JH992901_gene1332	3.301e-10	65.0	COG2270@1|root,COG2270@2|Bacteria,1GQJW@1117|Cyanobacteria,1JJTH@1189|Stigonemataceae	1117|Cyanobacteria	S	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD3_k127_7261023_13	86416.Clopa_2530	1.597e-61	219.0	COG1794@1|root,COG1794@2|Bacteria,1TR3U@1239|Firmicutes,24ADY@186801|Clostridia,36G2E@31979|Clostridiaceae	186801|Clostridia	M	Belongs to the aspartate glutamate racemases family	-	-	5.1.1.13	ko:K01779	ko00250,ko01054,map00250,map01054	-	R00491	RC00302	ko00000,ko00001,ko01000	-	-	iHN637.CLJU_RS14520	Asp_Glu_race
HKD3_k127_7261023_1	469383.Cwoe_1088	4.941e-202	636.0	COG0372@1|root,COG0372@2|Bacteria,2GJ7E@201174|Actinobacteria,4CPID@84995|Rubrobacteria	84995|Rubrobacteria	C	Belongs to the citrate synthase family	-	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
HKD3_k127_7261023_2	497964.CfE428DRAFT_3226	4.494e-176	561.0	COG1914@1|root,COG1914@2|Bacteria	2|Bacteria	P	metal ion transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	Nramp
HKD3_k127_7261023_11	448385.sce2665	4.829e-74	254.0	COG1335@1|root,COG1335@2|Bacteria,1MZP9@1224|Proteobacteria,42SNF@68525|delta/epsilon subdivisions,2X6IF@28221|Deltaproteobacteria,2Z22A@29|Myxococcales	28221|Deltaproteobacteria	Q	Isochorismatase family	-	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
HKD3_k127_7261023_30	929713.NIASO_13260	1.182e-07	58.0	2EBPV@1|root,335PY@2|Bacteria,4P5WA@976|Bacteroidetes	976|Bacteroidetes	S	Protein of unknown function (DUF1360)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1360
HKD3_k127_7261023_21	639030.JHVA01000001_gene572	3.245e-35	143.0	COG5478@1|root,COG5478@2|Bacteria,3Y7XG@57723|Acidobacteria,2JN0C@204432|Acidobacteriia	204432|Acidobacteriia	S	Low affinity iron permease	-	-	-	-	-	-	-	-	-	-	-	-	Iron_permease
HKD3_k127_7261023_14	661478.OP10G_2755	2.668e-54	195.0	COG0221@1|root,COG0221@2|Bacteria	2|Bacteria	C	inorganic diphosphatase activity	ppa	-	3.6.1.1	ko:K01507	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyrophosphatase
HKD3_k127_7261023_12	382464.ABSI01000010_gene3441	1.941e-63	225.0	COG2197@1|root,COG2197@2|Bacteria,46V5Z@74201|Verrucomicrobia,2IUBG@203494|Verrucomicrobiae	74201|Verrucomicrobia	T	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HKD3_k127_7261023_20	1396141.BATP01000039_gene1348	5.072e-39	162.0	COG4585@1|root,COG4585@2|Bacteria,46V1V@74201|Verrucomicrobia,2IVY4@203494|Verrucomicrobiae	203494|Verrucomicrobiae	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA_3
HKD3_k127_7261023_34	216596.RL2731	4.794e-05	55.0	COG0745@1|root,COG0784@1|root,COG4191@1|root,COG0745@2|Bacteria,COG0784@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TQQ9@28211|Alphaproteobacteria,4B88G@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3,Response_reg
HKD3_k127_7261023_3	1396418.BATQ01000104_gene5478	2.858e-166	539.0	COG0467@1|root,COG0467@2|Bacteria,46S8R@74201|Verrucomicrobia,2IVV3@203494|Verrucomicrobiae	203494|Verrucomicrobiae	T	KaiC	-	-	-	-	-	-	-	-	-	-	-	-	ATPase
HKD3_k127_7261023_7	251229.Chro_0549	3.206e-130	423.0	COG1028@1|root,COG1028@2|Bacteria,1G264@1117|Cyanobacteria,3VIYV@52604|Pleurocapsales	1117|Cyanobacteria	IQ	COGs COG1028 Dehydrogenase with different specificities (related to short-chain alcohol dehydrogenase)	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HKD3_k127_7261023_19	204669.Acid345_2557	4.763e-40	154.0	2B7KW@1|root,320RZ@2|Bacteria,3Y7ZF@57723|Acidobacteria,2JN97@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_7261023_18	1340493.JNIF01000003_gene3157	3.575e-40	154.0	COG1633@1|root,COG1633@2|Bacteria,3Y5HE@57723|Acidobacteria	57723|Acidobacteria	S	Domain of unknown function (DUF2383)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2383
HKD3_k127_7261023_29	68199.JNZO01000013_gene3966	1.078e-08	63.0	COG3427@1|root,COG3427@2|Bacteria,2I3CZ@201174|Actinobacteria	201174|Actinobacteria	E	oxidoreductase activity, acting on CH-OH group of donors	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_7261023_8	1183438.GKIL_3693	9.225e-128	417.0	COG3569@1|root,COG3569@2|Bacteria,1G2R6@1117|Cyanobacteria	1117|Cyanobacteria	L	Eukaryotic DNA topoisomerase I, catalytic core	-	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_I
HKD3_k127_7261023_6	452637.Oter_4139	6.225e-134	434.0	COG1793@1|root,COG1793@2|Bacteria,46TP1@74201|Verrucomicrobia	74201|Verrucomicrobia	L	PFAM ATP dependent DNA ligase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M
HKD3_k127_7261023_10	272134.KB731324_gene4403	3.68e-82	284.0	COG1295@1|root,COG1295@2|Bacteria,1G1HS@1117|Cyanobacteria,1H9BW@1150|Oscillatoriales	1117|Cyanobacteria	S	PFAM Ribonuclease BN-like family	rbn	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Virul_fac_BrkB
HKD3_k127_7261023_22	497964.CfE428DRAFT_6257	1.604e-24	108.0	2CDIR@1|root,348KT@2|Bacteria,46W4H@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_7261023_27	1112214.AHIS01000014_gene119	5.533e-11	64.0	2EFZF@1|root,339RM@2|Bacteria,1Q79X@1224|Proteobacteria,2UWHC@28211|Alphaproteobacteria,2K7QX@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_7261023_5	1123371.ATXH01000009_gene1077	1.693e-136	445.0	COG0438@1|root,COG0438@2|Bacteria,2GHNP@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
HKD3_k127_7261023_16	497964.CfE428DRAFT_3229	2.751e-48	182.0	COG3685@1|root,COG3685@2|Bacteria,46VCV@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Domain of unknown function (DUF892)	-	-	-	-	-	-	-	-	-	-	-	-	DUF892
HKD3_k127_7261023_15	1185876.BN8_00648	4.056e-54	196.0	COG4244@1|root,COG4244@2|Bacteria,4NPHV@976|Bacteroidetes,47PWW@768503|Cytophagia	976|Bacteroidetes	S	Predicted membrane protein (DUF2231)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2231
HKD3_k127_7261023_4	497964.CfE428DRAFT_3965	1.215e-144	478.0	COG5002@1|root,COG5002@2|Bacteria	2|Bacteria	T	protein histidine kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_4,PAS_9,Response_reg
HKD3_k127_7261023_26	649638.Trad_1405	1.843e-13	78.0	COG1597@1|root,COG1597@2|Bacteria,1WMEH@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	I	PFAM Diacylglycerol kinase, catalytic	-	-	-	-	-	-	-	-	-	-	-	-	DAGK_cat
HKD3_k127_7261023_17	1071073.KI530537_gene1595	4.06e-47	184.0	COG1387@1|root,COG1796@1|root,COG1387@2|Bacteria,COG1796@2|Bacteria,1TQ33@1239|Firmicutes,4HAI2@91061|Bacilli,1ZB3A@1386|Bacillus	91061|Bacilli	L	COG1796 DNA polymerase IV (family X)	polX	-	-	ko:K02347	-	-	-	-	ko00000,ko03400	-	-	-	DNA_pol_B_palm,DNA_pol_B_thumb,HHH_5,HHH_8,PHP
HKD3_k127_7261023_9	1163408.UU9_07109	1.321e-107	363.0	COG0668@1|root,COG0668@2|Bacteria,1PMY3@1224|Proteobacteria	1224|Proteobacteria	M	mechanosensitive ion channel	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel
HKD3_k127_7261023_25	216142.LT40_15905	2.197e-15	76.0	COG5487@1|root,COG5487@2|Bacteria,1NGAH@1224|Proteobacteria,1SGD7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	UPF0391 membrane protein	ytjA	-	-	-	-	-	-	-	-	-	-	-	DUF1328
HKD3_k127_7261023_0	497964.CfE428DRAFT_3471	1.177e-210	663.0	COG4122@1|root,COG4122@2|Bacteria,46TZ5@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Pup-ligase protein	-	-	6.3.1.19	ko:K13571	-	M00342	R11207	RC00090,RC00096	ko00000,ko00002,ko01000,ko03051	-	-	-	Pup_ligase
HKD3_k127_7261023_23	196490.AUEZ01000030_gene4424	9.818e-21	94.0	COG0748@1|root,COG0748@2|Bacteria,1RBVH@1224|Proteobacteria,2U6I3@28211|Alphaproteobacteria,3JY7V@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Pyridoxamine 5'-phosphate oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
HKD3_k127_7311424_1	2423.NA23_0206420	2.269e-92	314.0	COG1933@1|root,COG1933@2|Bacteria,2GDRW@200918|Thermotogae	200918|Thermotogae	L	exodeoxyribonuclease I activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_7311424_0	1163617.SCD_n00428	5.883e-197	627.0	COG0433@1|root,COG0433@2|Bacteria,1MU59@1224|Proteobacteria,2VIJY@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Bacterial protein of unknown function (DUF853)	yjgR	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF853
HKD3_k127_7311424_5	1237149.C900_00771	5.225e-18	90.0	2EHC3@1|root,33B3Y@2|Bacteria,4NZPQ@976|Bacteroidetes,47WF2@768503|Cytophagia	976|Bacteroidetes	S	Protein of unknown function (DUF1761)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1761
HKD3_k127_7311424_4	1403819.BATR01000125_gene4479	1.582e-29	123.0	COG0792@1|root,COG0792@2|Bacteria,46T9J@74201|Verrucomicrobia,2IUV7@203494|Verrucomicrobiae	203494|Verrucomicrobiae	L	Uncharacterised protein family UPF0102	-	-	-	ko:K07460	-	-	-	-	ko00000	-	-	-	UPF0102
HKD3_k127_7311424_2	497964.CfE428DRAFT_0568	2.191e-75	259.0	COG0164@1|root,COG0164@2|Bacteria,46SXH@74201|Verrucomicrobia	74201|Verrucomicrobia	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhB	-	3.1.26.4	ko:K03470	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_HII
HKD3_k127_7311424_3	497964.CfE428DRAFT_0567	4.195e-46	168.0	COG0335@1|root,COG0335@2|Bacteria,46T0S@74201|Verrucomicrobia	74201|Verrucomicrobia	J	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site	rplS	-	-	ko:K02884	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L19
HKD3_k127_7311424_7	1150469.RSPPHO_02781	2.173e-05	48.0	COG2165@1|root,COG2165@2|Bacteria,1PJ5F@1224|Proteobacteria,2VC7I@28211|Alphaproteobacteria,2JY2W@204441|Rhodospirillales	204441|Rhodospirillales	NU	general secretion pathway protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_7311424_6	518766.Rmar_0180	7.112e-06	48.0	COG3118@1|root,COG3118@2|Bacteria,4NQ5B@976|Bacteroidetes,1FJEP@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	O	Thioredoxin	trxA	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
HKD3_k127_7321049_2	497964.CfE428DRAFT_6520	1.91e-58	209.0	COG0811@1|root,COG0811@2|Bacteria,46T1R@74201|Verrucomicrobia	74201|Verrucomicrobia	U	MotA/TolQ/ExbB proton channel family	-	-	-	ko:K03561	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	MotA_ExbB
HKD3_k127_7321049_1	497964.CfE428DRAFT_5454	2.335e-104	347.0	COG0122@1|root,COG0122@2|Bacteria,46SVK@74201|Verrucomicrobia	74201|Verrucomicrobia	L	8-oxoguanine DNA glycosylase, N-terminal domain	alkA	-	4.2.99.18	ko:K03660	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD,OGG_N
HKD3_k127_7321049_0	349741.Amuc_0171	2.975e-160	520.0	COG0591@1|root,COG0591@2|Bacteria,46SPP@74201|Verrucomicrobia,2ITZE@203494|Verrucomicrobiae	203494|Verrucomicrobiae	E	Sodium:solute symporter family	-	-	-	-	-	-	-	-	-	-	-	-	SSF
HKD3_k127_7334677_5	671143.DAMO_0983	1.191e-17	89.0	COG0589@1|root,COG0589@2|Bacteria,2NPUM@2323|unclassified Bacteria	2|Bacteria	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD3_k127_7334677_3	76114.ebA2870	1.768e-72	252.0	COG1073@1|root,COG1073@2|Bacteria,1RDAY@1224|Proteobacteria,2VQGW@28216|Betaproteobacteria	28216|Betaproteobacteria	S	phosphoribosyltransferase	-	-	-	ko:K07100	-	-	-	-	ko00000	-	-	-	DLH,Pribosyltran
HKD3_k127_7334677_4	886293.Sinac_3851	7.608e-63	223.0	COG1926@1|root,COG1926@2|Bacteria,2J36S@203682|Planctomycetes	203682|Planctomycetes	F	Phosphoribosyl transferase domain	-	-	-	ko:K07100	-	-	-	-	ko00000	-	-	-	Pribosyltran
HKD3_k127_7334677_0	1121405.dsmv_0979	1.326e-287	892.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,42MHP@68525|delta/epsilon subdivisions,2WIQG@28221|Deltaproteobacteria,2MJ8G@213118|Desulfobacterales	28221|Deltaproteobacteria	I	PFAM AMP-dependent synthetase and ligase	-	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
HKD3_k127_7334677_2	1121405.dsmv_0978	3.242e-144	464.0	COG1071@1|root,COG1071@2|Bacteria,1MU5R@1224|Proteobacteria,42MHF@68525|delta/epsilon subdivisions,2WJ1R@28221|Deltaproteobacteria,2MMYC@213118|Desulfobacterales	28221|Deltaproteobacteria	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	pdhA	-	1.2.4.1	ko:K00161,ko:K21416	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
HKD3_k127_7334677_1	177439.DP2095	1.283e-161	514.0	COG0022@1|root,COG0022@2|Bacteria,1R8KB@1224|Proteobacteria,42MBM@68525|delta/epsilon subdivisions,2WJKG@28221|Deltaproteobacteria,2MMK7@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Transketolase, pyrimidine binding domain	pdhB	-	1.2.4.1	ko:K00162	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2753	Transket_pyr,Transketolase_C
HKD3_k127_7366063_0	497964.CfE428DRAFT_1691	2.677e-114	377.0	COG0524@1|root,COG0524@2|Bacteria,46U0Y@74201|Verrucomicrobia	74201|Verrucomicrobia	G	pfkB family carbohydrate kinase	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
HKD3_k127_7366063_1	1207076.ALAT01000216_gene4016	2.432e-11	68.0	COG0671@1|root,COG0671@2|Bacteria,1MZ81@1224|Proteobacteria,1SIC7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	PAP2 superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PAP2
HKD3_k127_7366063_3	1150469.RSPPHO_00750	1.506e-05	49.0	28HAG@1|root,2Z7MV@2|Bacteria,1PMGH@1224|Proteobacteria,2U27X@28211|Alphaproteobacteria,2JPS8@204441|Rhodospirillales	204441|Rhodospirillales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_7366063_2	3694.POPTR_0004s17650.1	2.693e-09	62.0	COG0154@1|root,KOG1211@2759|Eukaryota,37JFQ@33090|Viridiplantae,3GBRU@35493|Streptophyta,4JKGS@91835|fabids	35493|Streptophyta	J	Amidase	-	GO:0003674,GO:0003824,GO:0016787,GO:0016810,GO:0016811	3.5.1.4	ko:K01426	ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120	-	R02540,R03096,R03180,R03909,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000	-	-	-	Amidase
HKD3_k127_7408616_7	929556.Solca_1384	2.461e-05	49.0	COG1670@1|root,COG1670@2|Bacteria,4NNT2@976|Bacteroidetes,1J1AF@117747|Sphingobacteriia	976|Bacteroidetes	J	Acetyltransferase (GNAT) domain	-	-	2.3.1.128	ko:K03790	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_3
HKD3_k127_7408616_3	1134912.AJTV01000022_gene2935	7.179e-35	141.0	2BYH1@1|root,33SGP@2|Bacteria,1NT00@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_7408616_2	398767.Glov_2681	3.988e-54	201.0	COG0061@1|root,COG0061@2|Bacteria,1MUBC@1224|Proteobacteria,42MP8@68525|delta/epsilon subdivisions,2WKMR@28221|Deltaproteobacteria,43SZE@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	nadK	-	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	NAD_kinase
HKD3_k127_7408616_0	497964.CfE428DRAFT_5378	8.73e-86	290.0	COG1189@1|root,COG1189@2|Bacteria,46SM8@74201|Verrucomicrobia	74201|Verrucomicrobia	J	ribosomal RNA methyltransferase RrmJ FtsJ	-	-	2.1.1.226,2.1.1.227	ko:K06442	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ,S4
HKD3_k127_7408616_4	1396141.BATP01000058_gene1951	3.452e-29	129.0	COG1266@1|root,COG1266@2|Bacteria,46WKN@74201|Verrucomicrobia,2IUVF@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	CAAX protease self-immunity	-	-	-	-	-	-	-	-	-	-	-	-	Abi
HKD3_k127_7408616_1	497964.CfE428DRAFT_2030	9.951e-71	246.0	COG1040@1|root,COG1040@2|Bacteria,46T0D@74201|Verrucomicrobia	74201|Verrucomicrobia	S	competence protein	comFC	-	-	-	-	-	-	-	-	-	-	-	Pribosyltran
HKD3_k127_7408616_5	497964.CfE428DRAFT_2029	1.187e-28	119.0	COG0777@1|root,COG0777@2|Bacteria,46SI0@74201|Verrucomicrobia	74201|Verrucomicrobia	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA	accD	-	2.1.3.15,6.4.1.2	ko:K01963	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
HKD3_k127_7448505_23	760117.JN27_23445	2.82e-22	103.0	COG0664@1|root,COG0664@2|Bacteria,1N4C9@1224|Proteobacteria,2VVJC@28216|Betaproteobacteria,4761J@75682|Oxalobacteraceae	28216|Betaproteobacteria	T	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
HKD3_k127_7448505_8	240016.ABIZ01000001_gene1053	3.691e-153	488.0	COG0451@1|root,COG0451@2|Bacteria,46S80@74201|Verrucomicrobia,2ITWW@203494|Verrucomicrobiae	203494|Verrucomicrobiae	GM	GDP-mannose 4,6 dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	GDP_Man_Dehyd
HKD3_k127_7448505_12	497964.CfE428DRAFT_0105	2.834e-122	400.0	COG0180@1|root,COG0180@2|Bacteria,46SA6@74201|Verrucomicrobia	74201|Verrucomicrobia	J	PFAM aminoacyl-tRNA synthetase class Ib	trpS	-	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
HKD3_k127_7448505_24	1336237.JAEE01000006_gene792	6.006e-18	89.0	COG4922@1|root,COG4922@2|Bacteria,1MYTU@1224|Proteobacteria,1SAR7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_2
HKD3_k127_7448505_21	172088.AUGA01000059_gene4254	2.706e-28	116.0	COG3801@1|root,COG3801@2|Bacteria,1REJV@1224|Proteobacteria,2U8BB@28211|Alphaproteobacteria,3JYZ9@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	YjbR	-	-	-	-	-	-	-	-	-	-	-	-	YjbR
HKD3_k127_7448505_20	1282876.BAOK01000001_gene3354	1.382e-30	126.0	2C3PV@1|root,3307H@2|Bacteria,1N0Y3@1224|Proteobacteria,2UC7H@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein of unknown function (DUF2834)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2834
HKD3_k127_7448505_25	1121035.AUCH01000009_gene791	1.046e-16	83.0	COG1872@1|root,COG1872@2|Bacteria,1MZ4E@1224|Proteobacteria,2VWDY@28216|Betaproteobacteria,2KX5K@206389|Rhodocyclales	206389|Rhodocyclales	S	DUF167	-	-	-	ko:K09131	-	-	-	-	ko00000	-	-	-	DUF167
HKD3_k127_7448505_18	1267533.KB906738_gene2292	1.877e-53	191.0	COG2044@1|root,COG2044@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K06039	-	-	-	-	ko00000	-	-	-	DrsE
HKD3_k127_7448505_26	1120985.AUMI01000014_gene754	1.055e-14	85.0	COG1463@1|root,COG1463@2|Bacteria,1UI1N@1239|Firmicutes,4H3F6@909932|Negativicutes	909932|Negativicutes	Q	Virulence factor Mce family protein	-	-	-	ko:K02067	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaD
HKD3_k127_7448505_13	497964.CfE428DRAFT_0101	1.465e-99	334.0	COG1127@1|root,COG1127@2|Bacteria,46SRC@74201|Verrucomicrobia	74201|Verrucomicrobia	Q	PFAM ABC transporter related	ttg2A	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
HKD3_k127_7448505_15	497964.CfE428DRAFT_0100	4.539e-92	309.0	COG0767@1|root,COG0767@2|Bacteria,46SXR@74201|Verrucomicrobia	74201|Verrucomicrobia	Q	Permease MlaE	ttg2B	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE
HKD3_k127_7448505_22	497964.CfE428DRAFT_0099	3.236e-25	113.0	2CGGY@1|root,2ZGNS@2|Bacteria,46WT0@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_7448505_19	497964.CfE428DRAFT_0019	1.181e-33	135.0	296GV@1|root,2ZTSD@2|Bacteria,46WKD@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_7448505_11	497964.CfE428DRAFT_4930	3.888e-123	401.0	COG4974@1|root,COG4974@2|Bacteria,46SQ4@74201|Verrucomicrobia	74201|Verrucomicrobia	L	Phage integrase, N-terminal SAM-like domain	-	-	-	ko:K03733	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
HKD3_k127_7448505_2	247490.KSU1_C0312	1.43e-322	1006.0	COG0542@1|root,COG0542@2|Bacteria,2IXHI@203682|Planctomycetes	203682|Planctomycetes	O	with chaperone activity ATP-binding	clpC	-	-	ko:K03696	ko01100,map01100	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N,UVR
HKD3_k127_7448505_6	497964.CfE428DRAFT_3440	2.123e-164	524.0	COG3869@1|root,COG3869@2|Bacteria,46S55@74201|Verrucomicrobia	74201|Verrucomicrobia	E	Protein-arginine kinase	mcsB	-	2.7.14.1	ko:K19405	-	-	R11090	RC00002,RC00203	ko00000,ko01000	-	-	-	ATP-gua_Ptrans
HKD3_k127_7448505_16	497964.CfE428DRAFT_3441	7.324e-66	228.0	COG3880@1|root,COG3880@2|Bacteria,46SXX@74201|Verrucomicrobia	74201|Verrucomicrobia	S	PFAM UvrB UvrC protein	mcsA	-	-	ko:K19411	-	-	-	-	ko00000	-	-	-	UVR
HKD3_k127_7448505_10	497964.CfE428DRAFT_3442	1.37e-125	409.0	COG0115@1|root,COG0115@2|Bacteria,46S9W@74201|Verrucomicrobia	74201|Verrucomicrobia	E	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family	ilvE	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
HKD3_k127_7448505_14	497964.CfE428DRAFT_3443	3.45e-98	324.0	COG1136@1|root,COG1136@2|Bacteria,46UQZ@74201|Verrucomicrobia	74201|Verrucomicrobia	V	Part of the ABC transporter complex LolCDE involved in the translocation of	lolD	-	-	ko:K02003,ko:K09810	ko02010,map02010	M00255,M00258	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.125	-	-	ABC_tran
HKD3_k127_7448505_28	1396418.BATQ01000142_gene3310	9.311e-09	66.0	2DFF9@1|root,2ZRMT@2|Bacteria	2|Bacteria	S	Putative peptidoglycan binding domain	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_1
HKD3_k127_7448505_17	497964.CfE428DRAFT_3444	9.288e-60	209.0	COG0219@1|root,COG0219@2|Bacteria,46SYZ@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily	cspR	-	2.1.1.207	ko:K03216	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	SpoU_methylase
HKD3_k127_7448505_9	497964.CfE428DRAFT_0116	8.872e-137	442.0	COG0176@1|root,COG0176@2|Bacteria,46UAK@74201|Verrucomicrobia	74201|Verrucomicrobia	G	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway	tal	GO:0003674,GO:0003824,GO:0004801,GO:0016740,GO:0016744	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
HKD3_k127_7448505_27	1276756.AUEX01000003_gene718	6.11e-13	76.0	COG1917@1|root,COG1917@2|Bacteria	2|Bacteria	L	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HKD3_k127_7448505_3	497964.CfE428DRAFT_5899	1.975e-206	653.0	COG4992@1|root,COG4992@2|Bacteria,46UBT@74201|Verrucomicrobia	74201|Verrucomicrobia	E	Aminotransferase class-III	-	-	2.6.1.13	ko:K00819	ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130	-	R00667	RC00006,RC00062	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_3
HKD3_k127_7448505_29	497964.CfE428DRAFT_6257	7.653e-07	56.0	2CDIR@1|root,348KT@2|Bacteria,46W4H@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_7448505_1	497964.CfE428DRAFT_0818	0.0	1030.0	COG0046@1|root,COG0046@2|Bacteria,46S8Y@74201|Verrucomicrobia	74201|Verrucomicrobia	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C,GATase_5
HKD3_k127_7448505_5	316067.Geob_2890	6.094e-165	532.0	COG0034@1|root,COG0034@2|Bacteria,1MU0V@1224|Proteobacteria,42MDB@68525|delta/epsilon subdivisions,2WITV@28221|Deltaproteobacteria,43UES@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	-	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_6,GATase_7,Pribosyltran
HKD3_k127_7448505_7	497964.CfE428DRAFT_0621	2.56e-153	490.0	COG0150@1|root,COG0150@2|Bacteria,46SJ4@74201|Verrucomicrobia	74201|Verrucomicrobia	F	AIR synthase related protein domain protein	purM	-	6.3.3.1	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04208	RC01100	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
HKD3_k127_7448505_0	497964.CfE428DRAFT_6300	0.0	1042.0	COG1216@1|root,COG3250@1|root,COG1216@2|Bacteria,COG3250@2|Bacteria,46SAC@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Glycosyl transferase family 21	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_72,Glycos_transf_2
HKD3_k127_7448505_4	497964.CfE428DRAFT_1556	2.84e-165	526.0	COG0001@1|root,COG0001@2|Bacteria,46S67@74201|Verrucomicrobia	74201|Verrucomicrobia	H	intramolecular transferase activity, transferring amino groups	hemL	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
HKD3_k127_7486761_3	1437425.CSEC_0403	3.252e-41	154.0	COG1858@1|root,COG3502@1|root,COG1858@2|Bacteria,COG3502@2|Bacteria,2JGYD@204428|Chlamydiae	204428|Chlamydiae	C	Protein of unknown function (DUF952)	-	-	-	-	-	-	-	-	-	-	-	-	DUF952
HKD3_k127_7486761_5	382464.ABSI01000012_gene2111	2.372e-39	151.0	COG2010@1|root,COG2010@2|Bacteria,46W25@74201|Verrucomicrobia	74201|Verrucomicrobia	C	Haem-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Haem_bd
HKD3_k127_7486761_4	247490.KSU1_B0440	1.634e-39	151.0	2AVTU@1|root,31MME@2|Bacteria,2J2ZG@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_7486761_0	478741.JAFS01000002_gene551	0.0	1193.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,46SVA@74201|Verrucomicrobia,37FY0@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	H	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
HKD3_k127_7486761_6	1462526.BN990_03638	2.496e-10	72.0	COG0791@1|root,COG3409@1|root,COG0791@2|Bacteria,COG3409@2|Bacteria,1UW8N@1239|Firmicutes,4I2DP@91061|Bacilli,4C6RV@84406|Virgibacillus	91061|Bacilli	M	NlpC/P60 family	-	-	-	-	-	-	-	-	-	-	-	-	NLPC_P60,PG_binding_1
HKD3_k127_7486761_1	661478.OP10G_3225	2.322e-174	554.0	COG1063@1|root,COG1063@2|Bacteria	2|Bacteria	E	alcohol dehydrogenase	adh	-	1.1.1.14	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014	R00875,R01896	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
HKD3_k127_7486761_7	583355.Caka_2401	0.000302	48.0	COG0745@1|root,COG5000@1|root,COG0745@2|Bacteria,COG5000@2|Bacteria,46THS@74201|Verrucomicrobia	74201|Verrucomicrobia	T	ATP-binding region ATPase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c
HKD3_k127_7486761_2	56780.SYN_00323	2.388e-139	452.0	COG0517@1|root,COG1994@1|root,COG0517@2|Bacteria,COG1994@2|Bacteria,1MY9R@1224|Proteobacteria,42R1V@68525|delta/epsilon subdivisions,2WN7S@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	Belongs to the peptidase M50B family	-	-	-	-	-	-	-	-	-	-	-	-	CBS,Peptidase_M50,Peptidase_M50B
HKD3_k127_750726_3	504472.Slin_3706	5.65e-52	197.0	COG0455@1|root,COG0455@2|Bacteria	2|Bacteria	D	bacterial-type flagellum organization	-	-	-	ko:K02282,ko:K04562	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	AAA_31,CBP_BcsQ,CbiA,GSCFA
HKD3_k127_750726_4	1034943.BN1094_03368	2.004e-46	190.0	2E8FH@1|root,332TU@2|Bacteria,1NEHW@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_750726_2	936136.ARRT01000006_gene2231	1.404e-59	215.0	COG2520@1|root,COG2520@2|Bacteria,1PJK4@1224|Proteobacteria,2VB8G@28211|Alphaproteobacteria,4BHI1@82115|Rhizobiaceae	28211|Alphaproteobacteria	J	Methyltransferase FkbM domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_21
HKD3_k127_750726_1	936136.ARRT01000006_gene2232	1.008e-86	294.0	COG0500@1|root,COG2226@2|Bacteria,1RFDN@1224|Proteobacteria,2VDU0@28211|Alphaproteobacteria,4BISY@82115|Rhizobiaceae	28211|Alphaproteobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
HKD3_k127_750726_5	1124780.ANNU01000062_gene578	3.033e-16	87.0	COG0500@1|root,COG2226@2|Bacteria,4NJZ2@976|Bacteroidetes	976|Bacteroidetes	Q	Ubiquinone biosynthesis methyltransferase UbiE	-	-	2.1.1.137	ko:K07755	-	-	-	-	ko00000,ko01000	-	-	-	Methyltransf_11,Methyltransf_25
HKD3_k127_750726_0	1121406.JAEX01000002_gene1126	1.743e-124	414.0	COG0500@1|root,COG1215@1|root,COG1215@2|Bacteria,COG2226@2|Bacteria,1QU2F@1224|Proteobacteria,42P7H@68525|delta/epsilon subdivisions,2WKJA@28221|Deltaproteobacteria,2M9BR@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2,GtrA
HKD3_k127_7515036_0	452637.Oter_1454	1.111e-246	775.0	COG0841@1|root,COG0841@2|Bacteria,46SER@74201|Verrucomicrobia	74201|Verrucomicrobia	V	AcrB/AcrD/AcrF family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
HKD3_k127_7515036_1	452637.Oter_1455	2.016e-55	209.0	COG0845@1|root,COG0845@2|Bacteria,46US2@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Biotin-lipoyl like	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_D23
HKD3_k127_7515036_2	1232437.KL661957_gene2916	1.737e-18	89.0	COG0607@1|root,32YCZ@2|Bacteria,1N6NN@1224|Proteobacteria,42VWR@68525|delta/epsilon subdivisions,2WS4U@28221|Deltaproteobacteria,2MKU4@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Protein of unknown function (DUF2892)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2892
HKD3_k127_7515036_3	478741.JAFS01000002_gene328	1.944e-14	79.0	2DBSP@1|root,2ZAT9@2|Bacteria,46TYZ@74201|Verrucomicrobia,37GWI@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_7548104_0	862751.SACTE_0266	6.206e-74	256.0	COG1233@1|root,COG1233@2|Bacteria,2GMUC@201174|Actinobacteria	201174|Actinobacteria	Q	oxidoreductase	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	-	-	-	-	-	-	-	-	-	Amino_oxidase,DAO,NAD_binding_8
HKD3_k127_7548104_2	1144343.PMI41_03933	2.31e-14	80.0	29CEM@1|root,2ZZD2@2|Bacteria,1RE7K@1224|Proteobacteria,2U91P@28211|Alphaproteobacteria,43JT0@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_7548104_1	204669.Acid345_3044	1.181e-28	117.0	COG1064@1|root,COG1064@2|Bacteria,3Y3X1@57723|Acidobacteria,2JJDF@204432|Acidobacteriia	204432|Acidobacteriia	C	Zinc-binding dehydrogenase	-	-	1.1.1.1	ko:K00001	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
HKD3_k127_7552624_1	1379698.RBG1_1C00001G0607	1.06e-80	287.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,2NQNE@2323|unclassified Bacteria	2|Bacteria	T	Serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase,TPR_2,TPR_8
HKD3_k127_7552624_0	1122604.JONR01000004_gene851	7.163e-105	364.0	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1T234@1236|Gammaproteobacteria,1X903@135614|Xanthomonadales	135614|Xanthomonadales	S	Adenylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16
HKD3_k127_7566441_3	204669.Acid345_2966	9.7e-123	411.0	COG2079@1|root,COG2079@2|Bacteria,3Y5N1@57723|Acidobacteria,2JK64@204432|Acidobacteriia	204432|Acidobacteriia	S	MmgE/PrpD family	-	-	4.2.1.79	ko:K01720	ko00640,map00640	-	R04424	RC01152	ko00000,ko00001,ko01000	-	-	-	MmgE_PrpD
HKD3_k127_7566441_8	419947.MRA_2629A	7.48e-10	62.0	2DGZX@1|root,2ZXWY@2|Bacteria,2HDW7@201174|Actinobacteria	201174|Actinobacteria	-	-	-	GO:0008150,GO:0040008,GO:0045927,GO:0048518,GO:0050789,GO:0065007	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_7566441_7	102125.Xen7305DRAFT_00000310	7.055e-14	76.0	COG4113@1|root,COG4113@2|Bacteria	2|Bacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	-	-	-	-	-	-	-	-	-	PIN
HKD3_k127_7566441_4	382464.ABSI01000012_gene2201	3.587e-118	402.0	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria	2|Bacteria	S	cAMP biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	BTAD,TPR_11,TPR_16,TPR_7,TPR_8,Trans_reg_C
HKD3_k127_7566441_1	1122604.JONR01000004_gene851	1.49e-135	460.0	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1T234@1236|Gammaproteobacteria,1X903@135614|Xanthomonadales	135614|Xanthomonadales	S	Adenylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16
HKD3_k127_7566441_5	234267.Acid_7851	3.858e-109	381.0	COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,3Y6UN@57723|Acidobacteria	57723|Acidobacteria	K	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_7566441_2	382464.ABSI01000012_gene2201	2.055e-124	420.0	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria	2|Bacteria	S	cAMP biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	BTAD,TPR_11,TPR_16,TPR_7,TPR_8,Trans_reg_C
HKD3_k127_7566441_0	1122604.JONR01000004_gene851	3.928e-170	559.0	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1T234@1236|Gammaproteobacteria,1X903@135614|Xanthomonadales	135614|Xanthomonadales	S	Adenylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16
HKD3_k127_7566441_6	1122604.JONR01000004_gene851	4.166e-27	112.0	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1T234@1236|Gammaproteobacteria,1X903@135614|Xanthomonadales	135614|Xanthomonadales	S	Adenylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16
HKD3_k127_7576291_7	351160.RCIX2633	4.004e-23	104.0	COG0604@1|root,arCOG01458@2157|Archaea,2XURG@28890|Euryarchaeota,2N9N6@224756|Methanomicrobia	224756|Methanomicrobia	C	Zinc-binding dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N_2
HKD3_k127_7576291_8	1380347.JNII01000008_gene4314	4.417e-17	84.0	2C6EM@1|root,2ZFYQ@2|Bacteria,2GXX8@201174|Actinobacteria	201174|Actinobacteria	S	YCII-related domain	-	-	-	ko:K09780	-	-	-	-	ko00000	-	-	-	YCII
HKD3_k127_7576291_6	1219031.BBJR01000040_gene2707	2.674e-51	194.0	COG3768@1|root,COG3768@2|Bacteria,1NNZU@1224|Proteobacteria	1224|Proteobacteria	S	Domain of unknown function (DUF697)	-	-	-	-	-	-	-	-	-	-	-	-	DUF697
HKD3_k127_7576291_0	497964.CfE428DRAFT_5656	5.257e-282	884.0	COG0204@1|root,COG0318@1|root,COG0204@2|Bacteria,COG0318@2|Bacteria,46SG3@74201|Verrucomicrobia	74201|Verrucomicrobia	IQ	PFAM AMP-dependent synthetase and ligase	caiC	-	2.3.1.40,6.2.1.20	ko:K05939	ko00071,ko00564,map00071,map00564	-	R01406,R04864	RC00014,RC00039,RC00041	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C,Acyltransferase
HKD3_k127_7576291_2	497964.CfE428DRAFT_5659	5.922e-135	443.0	COG2271@1|root,COG2271@2|Bacteria,46TP4@74201|Verrucomicrobia	74201|Verrucomicrobia	G	Sugar (and other) transporter	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD3_k127_7576291_4	497964.CfE428DRAFT_2592	1.577e-87	309.0	COG3786@1|root,COG3786@2|Bacteria,46STB@74201|Verrucomicrobia	74201|Verrucomicrobia	S	L,D-transpeptidase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	YkuD
HKD3_k127_7576291_3	497964.CfE428DRAFT_0236	1.047e-130	432.0	COG0030@1|root,COG1443@1|root,COG0030@2|Bacteria,COG1443@2|Bacteria,46T1S@74201|Verrucomicrobia	74201|Verrucomicrobia	I	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	-	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	NUDIX,RrnaAD
HKD3_k127_7576291_5	497964.CfE428DRAFT_1998	1.055e-70	254.0	COG3597@1|root,COG3597@2|Bacteria	2|Bacteria	S	protein domain associated with	ycgC	-	-	ko:K03595,ko:K06883,ko:K06946	-	-	-	-	ko00000,ko03009,ko03029	-	-	-	DUF697,MMR_HSR1
HKD3_k127_7576291_1	452637.Oter_3805	4.261e-185	589.0	COG0021@1|root,COG0021@2|Bacteria,46SHW@74201|Verrucomicrobia,3K74F@414999|Opitutae	414999|Opitutae	G	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
HKD3_k127_7614799_1	580332.Slit_1558	2.628e-47	177.0	arCOG05203@1|root,31A0K@2|Bacteria,1RHZR@1224|Proteobacteria,2VX85@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_7614799_0	693986.MOC_4621	1.715e-73	250.0	COG1926@1|root,COG2312@1|root,COG1926@2|Bacteria,COG2312@2|Bacteria,1RAG8@1224|Proteobacteria,2U5HS@28211|Alphaproteobacteria,1JTD3@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	Phosphoribosyl transferase domain	-	-	-	ko:K07100	-	-	-	-	ko00000	-	-	-	Pribosyltran
HKD3_k127_7642189_0	1379698.RBG1_1C00001G1377	7.495e-30	137.0	COG4409@1|root,COG4409@2|Bacteria,2NRD7@2323|unclassified Bacteria	2|Bacteria	G	exo-alpha-(2->6)-sialidase activity	-	-	-	-	-	-	-	-	-	-	-	-	ASH,BNR_2,Big_3_2,CBM_35,DUF1080,F5_F8_type_C,PKD,RicinB_lectin_2,Trehalase
HKD3_k127_7646124_2	706587.Desti_1032	2.187e-171	552.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJ8D@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296,ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
HKD3_k127_7646124_5	706587.Desti_1031	2.205e-89	310.0	COG0845@1|root,COG0845@2|Bacteria,1MUFW@1224|Proteobacteria,42N4G@68525|delta/epsilon subdivisions,2WJ8A@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K03585,ko:K07799	ko01501,ko01503,ko02020,map01501,map01503,map02020	M00646,M00647,M00648,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1,8.A.1.6	-	-	HlyD_D23
HKD3_k127_7646124_10	1123368.AUIS01000018_gene731	1.651e-35	141.0	COG1846@1|root,COG1846@2|Bacteria,1PC0Q@1224|Proteobacteria,1SXNR@1236|Gammaproteobacteria,2NDAB@225057|Acidithiobacillales	225057|Acidithiobacillales	K	Transcriptional regulator, MarR	-	-	-	ko:K06075	-	-	-	-	ko00000,ko03000	-	-	-	MarR_2
HKD3_k127_7646124_7	1403819.BATR01000124_gene4416	1.879e-68	254.0	COG1807@1|root,COG1807@2|Bacteria	2|Bacteria	M	4-amino-4-deoxy-L-arabinose transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HKD3_k127_7646124_1	497964.CfE428DRAFT_1789	3.17e-176	561.0	COG0195@1|root,COG0195@2|Bacteria,46TRP@74201|Verrucomicrobia	74201|Verrucomicrobia	K	Participates in both transcription termination and antitermination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KH_5,NusA_N,S1
HKD3_k127_7646124_0	497964.CfE428DRAFT_1790	2.307e-271	854.0	COG0532@1|root,COG0532@2|Bacteria,46S8V@74201|Verrucomicrobia	74201|Verrucomicrobia	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,IF-2,IF2_N
HKD3_k127_7646124_11	497964.CfE428DRAFT_1791	9.103e-28	117.0	COG0858@1|root,COG0858@2|Bacteria,46TBI@74201|Verrucomicrobia	74201|Verrucomicrobia	J	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA	rbfA	-	-	ko:K02834	-	-	-	-	ko00000,ko03009	-	-	-	RBFA
HKD3_k127_7646124_3	497964.CfE428DRAFT_1792	1.85e-111	369.0	COG0618@1|root,COG0618@2|Bacteria,46T03@74201|Verrucomicrobia	74201|Verrucomicrobia	S	PFAM phosphoesterase RecJ domain protein	-	-	3.1.13.3,3.1.3.7	ko:K06881	ko00920,ko01100,ko01120,map00920,map01100,map01120	-	R00188,R00508	RC00078	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
HKD3_k127_7646124_4	497964.CfE428DRAFT_1793	3.917e-100	335.0	COG0130@1|root,COG0130@2|Bacteria,46SJR@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs	truB	-	5.4.99.25	ko:K03177	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruB_C_2,TruB_N
HKD3_k127_7646124_6	1403819.BATR01000137_gene4884	3.699e-88	301.0	COG0196@1|root,COG0196@2|Bacteria,46SZ6@74201|Verrucomicrobia,2IU48@203494|Verrucomicrobiae	203494|Verrucomicrobiae	H	Riboflavin kinase	-	-	2.7.1.26,2.7.7.2	ko:K11753	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00161,R00549	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_syn,Flavokinase
HKD3_k127_7646124_9	452637.Oter_2569	5.273e-44	166.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	algT	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
HKD3_k127_7646124_12	1242864.D187_006974	9.755e-15	83.0	2EIJE@1|root,33CAQ@2|Bacteria	2|Bacteria	S	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_7646124_8	497964.CfE428DRAFT_2462	1.199e-64	225.0	COG0105@1|root,COG0105@2|Bacteria,46T8K@74201|Verrucomicrobia	74201|Verrucomicrobia	F	Nucleoside diphosphate kinase	ndk	-	2.7.4.6	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	M00049,M00050,M00052,M00053	R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895	RC00002	ko00000,ko00001,ko00002,ko01000,ko04131	-	-	-	NDK
HKD3_k127_7647865_23	478741.JAFS01000002_gene900	3.166e-49	178.0	COG0581@1|root,COG0581@2|Bacteria,46T8D@74201|Verrucomicrobia,37GCU@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	P	Binding-protein-dependent transport system inner membrane component	pstA	-	-	ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
HKD3_k127_7647865_11	1156937.MFUM_300006	1.214e-111	366.0	COG1117@1|root,COG1117@2|Bacteria,46SB2@74201|Verrucomicrobia,37G7T@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	pstB	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
HKD3_k127_7647865_22	1403819.BATR01000162_gene5405	4.242e-58	211.0	COG0704@1|root,COG0704@2|Bacteria,46SUX@74201|Verrucomicrobia,2IUGT@203494|Verrucomicrobiae	203494|Verrucomicrobiae	P	PhoU domain	-	-	-	ko:K02039	-	-	-	-	ko00000	-	-	-	PhoU
HKD3_k127_7647865_0	1156937.MFUM_1030014	2.33e-253	802.0	COG0855@1|root,COG0855@2|Bacteria,46SB4@74201|Verrucomicrobia,37GEJ@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	P	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)	ppk	-	2.7.4.1	ko:K00937	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PP_kinase,PP_kinase_C,PP_kinase_N
HKD3_k127_7647865_19	1038859.AXAU01000001_gene3555	5.457e-69	241.0	COG1940@1|root,COG1940@2|Bacteria,1NSQA@1224|Proteobacteria,2TSPZ@28211|Alphaproteobacteria,3JRYQ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	GK	Transcriptional regulator sugar kinase	-	-	2.7.1.63	ko:K00886	ko00010,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R02187,R02189	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
HKD3_k127_7647865_33	251221.35212318	1.269e-19	94.0	COG2062@1|root,COG2062@2|Bacteria,1G6QD@1117|Cyanobacteria	1117|Cyanobacteria	T	Phosphohistidine phosphatase, SixA	sixA	-	-	ko:K08296	-	-	-	-	ko00000,ko01000	-	-	-	His_Phos_1
HKD3_k127_7647865_32	497964.CfE428DRAFT_3451	1.255e-21	101.0	COG1314@1|root,COG1314@2|Bacteria,46T75@74201|Verrucomicrobia	74201|Verrucomicrobia	U	PFAM Preprotein translocase SecG subunit	secG	-	-	ko:K03075	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecG
HKD3_k127_7647865_15	240016.ABIZ01000001_gene5803	5.315e-77	265.0	COG1694@1|root,COG3956@2|Bacteria,46SNM@74201|Verrucomicrobia,2ITIM@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	MazG nucleotide pyrophosphohydrolase domain	-	-	3.6.1.66	ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000	-	-	-	MazG
HKD3_k127_7647865_20	314230.DSM3645_26499	5.963e-63	225.0	COG1011@1|root,COG1940@1|root,COG1011@2|Bacteria,COG1940@2|Bacteria,2J05I@203682|Planctomycetes	203682|Planctomycetes	GK	Haloacid dehalogenase-like hydrolase	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2
HKD3_k127_7647865_28	497964.CfE428DRAFT_1798	9.827e-32	137.0	COG0784@1|root,COG0784@2|Bacteria	2|Bacteria	T	Response regulator, receiver	-	-	-	ko:K02657,ko:K20972	ko02020,ko02025,map02020,map02025	M00507	-	-	ko00000,ko00001,ko00002,ko01001,ko02022,ko02035,ko02044	-	-	-	HATPase_c,HisKA,Hpt,Response_reg
HKD3_k127_7647865_6	497964.CfE428DRAFT_1495	1.843e-140	462.0	COG0318@1|root,COG0318@2|Bacteria,46T7I@74201|Verrucomicrobia	74201|Verrucomicrobia	IQ	AMP-binding enzyme	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
HKD3_k127_7647865_29	497964.CfE428DRAFT_1496	5.866e-31	122.0	COG0254@1|root,COG0254@2|Bacteria,46T4W@74201|Verrucomicrobia	74201|Verrucomicrobia	J	ribosomal protein L31	rpmE	-	-	ko:K02909	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L31
HKD3_k127_7647865_5	497964.CfE428DRAFT_1497	1.424e-147	475.0	COG0216@1|root,COG0216@2|Bacteria,46S6F@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA	prfA	-	-	ko:K02835	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
HKD3_k127_7647865_2	247490.KSU1_C0781	2.017e-177	572.0	COG1404@1|root,COG1404@2|Bacteria	2|Bacteria	O	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
HKD3_k127_7647865_10	323848.Nmul_A0535	4.489e-117	392.0	COG3319@1|root,COG3319@2|Bacteria,1N402@1224|Proteobacteria,2W4G7@28216|Betaproteobacteria	28216|Betaproteobacteria	Q	amino acid activation for nonribosomal peptide biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_7647865_14	1396418.BATQ01000133_gene4052	1.151e-81	280.0	COG2890@1|root,COG2890@2|Bacteria,46SZE@74201|Verrucomicrobia,2IU5P@203494|Verrucomicrobiae	203494|Verrucomicrobiae	J	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif	prmC	-	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS
HKD3_k127_7647865_1	497964.CfE428DRAFT_1506	2.238e-199	628.0	COG0766@1|root,COG0766@2|Bacteria,46S6Q@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine	murA	-	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase
HKD3_k127_7647865_30	399739.Pmen_4385	2.917e-28	119.0	COG3296@1|root,COG3296@2|Bacteria,1RET3@1224|Proteobacteria,1S4H0@1236|Gammaproteobacteria,1YGFD@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	S	Domain of unknown function (DUF4870)	-	-	-	ko:K09940	-	-	-	-	ko00000	-	-	-	DUF4870
HKD3_k127_7647865_13	429009.Adeg_1744	3.563e-86	296.0	COG0648@1|root,COG0648@2|Bacteria,1TP1D@1239|Firmicutes,2499E@186801|Clostridia,42GGT@68295|Thermoanaerobacterales	186801|Clostridia	L	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin	nfo	-	3.1.21.2	ko:K01151	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AP_endonuc_2
HKD3_k127_7647865_3	497964.CfE428DRAFT_2960	1.811e-170	563.0	COG2982@1|root,COG2982@2|Bacteria,46SSM@74201|Verrucomicrobia	74201|Verrucomicrobia	M	AsmA-like C-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	AsmA_2
HKD3_k127_7647865_26	497964.CfE428DRAFT_2239	4.246e-37	145.0	COG2322@1|root,COG2322@2|Bacteria,46SZT@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Protein of unknown function (DUF420)	-	-	-	ko:K08976	-	-	-	-	ko00000	-	-	-	DUF420
HKD3_k127_7647865_21	497964.CfE428DRAFT_0877	1.574e-58	213.0	COG1376@1|root,COG1376@2|Bacteria,46W0P@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Lysin motif	-	-	-	-	-	-	-	-	-	-	-	-	LysM
HKD3_k127_7647865_7	497964.CfE428DRAFT_0876	6.515e-132	428.0	COG0825@1|root,COG0825@2|Bacteria,46SE1@74201|Verrucomicrobia	74201|Verrucomicrobia	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA	accA	-	2.1.3.15,6.4.1.2	ko:K01962	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	ACCA
HKD3_k127_7647865_16	215803.DB30_3730	2.517e-76	266.0	COG2819@1|root,COG2819@2|Bacteria,1N4R1@1224|Proteobacteria,43BZF@68525|delta/epsilon subdivisions,2X7A6@28221|Deltaproteobacteria,2YXXF@29|Myxococcales	28221|Deltaproteobacteria	S	Putative esterase	-	-	-	-	-	-	-	-	-	-	-	-	CBM_20,Esterase
HKD3_k127_7647865_18	714943.Mucpa_3723	1.243e-69	244.0	COG2382@1|root,COG2382@2|Bacteria,4NGIA@976|Bacteroidetes,1IQTD@117747|Sphingobacteriia	976|Bacteroidetes	P	Putative esterase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Esterase
HKD3_k127_7647865_17	497964.CfE428DRAFT_6143	4.887e-76	260.0	COG0163@1|root,COG0163@2|Bacteria,46V9E@74201|Verrucomicrobia	74201|Verrucomicrobia	H	Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN	ubiX	-	2.5.1.129	ko:K03186	ko00130,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00627,map00940,map01100,map01110,map01120,map01220	M00117	R01238,R02952,R03367,R04985,R04986,R11225	RC00391,RC00814,RC03392	ko00000,ko00001,ko00002,ko01000	-	-	-	Flavoprotein
HKD3_k127_7647865_24	478741.JAFS01000002_gene891	5.307e-42	164.0	COG2121@1|root,COG2121@2|Bacteria,46SZ0@74201|Verrucomicrobia,37GQD@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	S	Domain of unknown function (DUF374)	-	-	-	ko:K09778	-	-	-	-	ko00000	-	-	-	DUF374
HKD3_k127_7647865_8	240016.ABIZ01000001_gene1548	2.685e-127	413.0	COG0190@1|root,COG0190@2|Bacteria,46TG7@74201|Verrucomicrobia,2ITSZ@203494|Verrucomicrobiae	203494|Verrucomicrobiae	H	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate	folD	-	1.5.1.5,3.5.4.9	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R01220,R01655	RC00202,RC00578	ko00000,ko00001,ko00002,ko01000	-	-	-	THF_DHG_CYH,THF_DHG_CYH_C
HKD3_k127_7647865_12	497964.CfE428DRAFT_0829	2.043e-110	367.0	COG0644@1|root,COG0644@2|Bacteria	2|Bacteria	C	geranylgeranyl reductase activity	fixC	-	1.3.99.38	ko:K21401	-	-	-	-	ko00000,ko01000	-	-	-	DAO,FAD_binding_3,Trp_halogenase
HKD3_k127_7647865_9	926550.CLDAP_30780	3.243e-127	416.0	COG0517@1|root,COG1994@1|root,COG0517@2|Bacteria,COG1994@2|Bacteria,2G719@200795|Chloroflexi	200795|Chloroflexi	S	Belongs to the peptidase M50B family	-	-	-	-	-	-	-	-	-	-	-	-	CBS,Peptidase_M50
HKD3_k127_7647865_4	1123070.KB899248_gene118	2.251e-149	483.0	COG0592@1|root,COG0592@2|Bacteria,46SPK@74201|Verrucomicrobia,2ITMH@203494|Verrucomicrobiae	203494|Verrucomicrobiae	L	Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria	-	-	2.7.7.7	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3
HKD3_k127_7647865_25	497964.CfE428DRAFT_2289	3.921e-41	153.0	COG0593@1|root,COG0593@2|Bacteria,46S6H@74201|Verrucomicrobia	74201|Verrucomicrobia	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids	dnaA	-	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA,Bac_DnaA_C,DnaA_N
HKD3_k127_7704285_6	1168067.JAGP01000001_gene1216	5.503e-30	124.0	2E7HQ@1|root,33207@2|Bacteria,1NCYR@1224|Proteobacteria,1SRXH@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function (DUF4231)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4231
HKD3_k127_7704285_2	1267534.KB906754_gene2817	5.508e-171	550.0	COG2837@1|root,COG2837@2|Bacteria,3Y3R0@57723|Acidobacteria	57723|Acidobacteria	P	iron assimilation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_7704285_3	1267534.KB906754_gene2818	2.293e-166	533.0	2DBCN@1|root,2Z8EJ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_7704285_1	1380354.JIAN01000005_gene1630	6.152e-201	632.0	COG0753@1|root,COG0753@2|Bacteria,2I4NI@201174|Actinobacteria	201174|Actinobacteria	P	catalase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_7704285_5	1267533.KB906739_gene2479	1.411e-63	220.0	29FX8@1|root,302UX@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_7704285_0	1267534.KB906754_gene2823	5.142e-236	751.0	COG2010@1|root,COG2010@2|Bacteria,3Y31J@57723|Acidobacteria,2JKC9@204432|Acidobacteriia	204432|Acidobacteriia	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_7704285_4	497964.CfE428DRAFT_5673	3.224e-101	339.0	COG2107@1|root,COG2107@2|Bacteria,46U2Z@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)	mqnD	-	-	ko:K11785	ko00130,ko01110,map00130,map01110	-	R08589	RC02330	ko00000,ko00001,ko01000	-	-	-	VitK2_biosynth
HKD3_k127_7718352_9	1038860.AXAP01000047_gene1028	1.171e-59	210.0	COG0399@1|root,COG0399@2|Bacteria,1MUPN@1224|Proteobacteria,2TRIQ@28211|Alphaproteobacteria,3JU8X@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Belongs to the DegT DnrJ EryC1 family	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
HKD3_k127_7718352_3	1121033.AUCF01000008_gene5719	5.446e-119	390.0	COG0463@1|root,COG0463@2|Bacteria,1MXC1@1224|Proteobacteria,2TVY5@28211|Alphaproteobacteria,2JYTD@204441|Rhodospirillales	204441|Rhodospirillales	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HKD3_k127_7718352_15	1303518.CCALI_02808	1.27e-16	94.0	COG1807@1|root,COG1807@2|Bacteria	2|Bacteria	M	4-amino-4-deoxy-L-arabinose transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_7718352_8	405948.SACE_7108	1.113e-68	244.0	COG2227@1|root,COG2227@2|Bacteria,2H217@201174|Actinobacteria	201174|Actinobacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_7718352_11	1501230.ET33_00540	3.486e-46	179.0	COG0615@1|root,COG0615@2|Bacteria,1VNXB@1239|Firmicutes	1239|Firmicutes	IM	Sulfotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_3
HKD3_k127_7718352_7	1278073.MYSTI_04368	1.328e-78	278.0	COG4122@1|root,COG4122@2|Bacteria,1R9D7@1224|Proteobacteria,42ZQ8@68525|delta/epsilon subdivisions,2WVSH@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_24
HKD3_k127_7718352_1	880073.Calab_2669	2.307e-197	654.0	COG0438@1|root,COG1216@1|root,COG3551@1|root,COG0438@2|Bacteria,COG1216@2|Bacteria,COG3551@2|Bacteria,2NPQ4@2323|unclassified Bacteria	2|Bacteria	J	Glycosyltransferase like family 2	-	-	-	ko:K07011,ko:K20444	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.1.3	GT2,GT4	-	Glyco_trans_1_4,Glycos_transf_2,Methyltransf_23
HKD3_k127_7718352_6	349741.Amuc_0395	3.174e-92	310.0	COG0689@1|root,COG0689@2|Bacteria,46U55@74201|Verrucomicrobia,2ITNM@203494|Verrucomicrobiae	203494|Verrucomicrobiae	J	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates	rph	-	2.7.7.56	ko:K00989	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RNase_PH,RNase_PH_C
HKD3_k127_7718352_2	497964.CfE428DRAFT_2886	2.552e-168	533.0	COG1089@1|root,COG1089@2|Bacteria,46SH0@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose	gmd	-	4.2.1.47	ko:K01711	ko00051,ko00520,ko01100,map00051,map00520,map01100	-	R00888	RC00402	ko00000,ko00001,ko01000	-	-	-	GDP_Man_Dehyd
HKD3_k127_7718352_10	497964.CfE428DRAFT_3536	1.621e-57	207.0	COG1376@1|root,COG1376@2|Bacteria,46VIF@74201|Verrucomicrobia	2|Bacteria	S	PFAM ErfK YbiS YcfS YnhG family protein	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_1,YkuD
HKD3_k127_7718352_5	497964.CfE428DRAFT_3888	5.389e-95	319.0	COG0084@1|root,COG0084@2|Bacteria,46SKF@74201|Verrucomicrobia	74201|Verrucomicrobia	L	TatD related DNase	tatD	-	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
HKD3_k127_7718352_14	748280.NH8B_0901	1.079e-35	138.0	COG3865@1|root,COG3865@2|Bacteria,1N7IY@1224|Proteobacteria,2VRJ0@28216|Betaproteobacteria,2KT22@206351|Neisseriales	206351|Neisseriales	S	3-demethylubiquinone-9 3-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	3-dmu-9_3-mt
HKD3_k127_7718352_17	1894.JOER01000017_gene4849	3.798e-13	70.0	COG3865@1|root,COG3865@2|Bacteria,2IIAX@201174|Actinobacteria	201174|Actinobacteria	S	3-demethylubiquinone-9 3-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	3-dmu-9_3-mt
HKD3_k127_7718352_0	330214.NIDE3482	6.566e-223	696.0	COG4447@1|root,COG4447@2|Bacteria	2|Bacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	BNR
HKD3_k127_7718352_12	1267535.KB906767_gene3397	8.316e-39	151.0	COG1977@1|root,COG1977@2|Bacteria,3Y5J3@57723|Acidobacteria,2JJVU@204432|Acidobacteriia	204432|Acidobacteriia	H	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_7718352_4	631362.Thi970DRAFT_02437	1.73e-114	382.0	COG0387@1|root,COG0387@2|Bacteria,1MWD8@1224|Proteobacteria,1RME3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Calcium Proton	chaA	GO:0003674,GO:0005215,GO:0005451,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0006814,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015079,GO:0015081,GO:0015291,GO:0015297,GO:0015298,GO:0015299,GO:0015318,GO:0015385,GO:0015386,GO:0015491,GO:0015672,GO:0016020,GO:0016021,GO:0022804,GO:0022821,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0031226,GO:0034220,GO:0035725,GO:0044425,GO:0044459,GO:0044464,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:0099516,GO:1902600	-	ko:K07300	-	-	-	-	ko00000,ko02000	2.A.19	-	iB21_1397.B21_01204,iEC55989_1330.EC55989_1314,iECBD_1354.ECBD_2403,iECB_1328.ECB_01194,iECD_1391.ECD_01194,iECIAI1_1343.ECIAI1_1238,iECO103_1326.ECO103_1321,iECO111_1330.ECO111_1548,iECO26_1355.ECO26_1732,iECSE_1348.ECSE_1269,iECW_1372.ECW_m1308,iETEC_1333.ETEC_1322,iEcE24377_1341.EcE24377A_1366,iEcHS_1320.EcHS_A1324,iEcolC_1368.EcolC_2407,iSSON_1240.SSON_1961,iSbBS512_1146.SbBS512_E1383,iUMNK88_1353.UMNK88_1535,iWFL_1372.ECW_m1308	Na_Ca_ex
HKD3_k127_7718352_13	1385935.N836_29710	4.95e-36	142.0	COG0454@1|root,COG0456@2|Bacteria,1G646@1117|Cyanobacteria,1HC70@1150|Oscillatoriales	1117|Cyanobacteria	K	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10
HKD3_k127_7718352_16	1430440.MGMSRv2_1983	2.65e-16	83.0	2DNPH@1|root,32YF1@2|Bacteria,1NARM@1224|Proteobacteria,2UJNP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_7718352_21	1430440.MGMSRv2_1983	2.535e-08	55.0	2DNPH@1|root,32YF1@2|Bacteria,1NARM@1224|Proteobacteria,2UJNP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_7718352_22	566461.SSFG_03801	2.863e-08	58.0	2B7FZ@1|root,320JU@2|Bacteria,2IQBZ@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_7718352_18	1123274.KB899413_gene889	8.9e-13	68.0	2B9ZZ@1|root,323DM@2|Bacteria	2|Bacteria	S	COG NOG15344 non supervised orthologous group	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_7735619_1	1449049.JONW01000005_gene1181	2.595e-30	125.0	COG1180@1|root,COG1180@2|Bacteria,1NQC1@1224|Proteobacteria,2TV8Y@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
HKD3_k127_7735619_0	1449049.JONW01000005_gene1182	5.887e-283	874.0	COG1882@1|root,COG1882@2|Bacteria,1MWBF@1224|Proteobacteria,2TT7K@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	formate C-acetyltransferase glycine radical	-	-	2.3.1.54	ko:K00656	ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120	-	R00212,R06987	RC00004,RC01181,RC02742,RC02833	ko00000,ko00001,ko01000	-	-	-	Gly_radical,PFL-like
HKD3_k127_7743925_4	234267.Acid_7180	4.118e-60	214.0	COG1331@1|root,COG1331@2|Bacteria,3Y3AA@57723|Acidobacteria	57723|Acidobacteria	O	Protein of unknown function, DUF255	-	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	GlcNAc_2-epim,Thioredox_DsbH
HKD3_k127_7743925_2	1121015.N789_02375	8.313e-82	280.0	COG0730@1|root,COG0730@2|Bacteria,1RD5A@1224|Proteobacteria,1S6M1@1236|Gammaproteobacteria,1XAJC@135614|Xanthomonadales	135614|Xanthomonadales	S	Sulfite exporter TauE/SafE	-	-	-	-	-	-	-	-	-	-	-	-	TauE
HKD3_k127_7743925_1	497964.CfE428DRAFT_0672	2.677e-135	442.0	COG1253@1|root,COG1253@2|Bacteria,46VJ6@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Transporter associated domain	-	-	-	-	-	-	-	-	-	-	-	-	CorC_HlyC,DUF21
HKD3_k127_7743925_3	497964.CfE428DRAFT_0673	1.046e-76	271.0	COG1253@1|root,COG1253@2|Bacteria,46W8Q@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Domain of unknown function DUF21	-	-	-	-	-	-	-	-	-	-	-	-	DUF21
HKD3_k127_7743925_0	351607.Acel_1143	1.29e-232	734.0	COG3387@1|root,COG3387@2|Bacteria,2GJAD@201174|Actinobacteria,4ES2D@85013|Frankiales	201174|Actinobacteria	G	Glycoside hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_15
HKD3_k127_7743925_5	448385.sce1010	5.368e-58	206.0	COG0454@1|root,COG0456@2|Bacteria,1RCYQ@1224|Proteobacteria,43BYG@68525|delta/epsilon subdivisions,2X3A9@28221|Deltaproteobacteria,2YV3A@29|Myxococcales	28221|Deltaproteobacteria	K	FR47-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HKD3_k127_7743925_9	390989.JOEG01000001_gene5094	4.349e-32	143.0	COG3055@1|root,COG4934@1|root,COG3055@2|Bacteria,COG4934@2|Bacteria,2IF2T@201174|Actinobacteria,4DBYG@85008|Micromonosporales	201174|Actinobacteria	O	Peptidase S8 and S53 subtilisin kexin sedolisin	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Kelch_1
HKD3_k127_7743925_7	1123508.JH636450_gene7219	2.35e-35	154.0	COG1404@1|root,COG2911@1|root,COG2931@1|root,COG3210@1|root,COG3391@1|root,COG4935@1|root,COG1404@2|Bacteria,COG2911@2|Bacteria,COG2931@2|Bacteria,COG3210@2|Bacteria,COG3391@2|Bacteria,COG4935@2|Bacteria,2IZWN@203682|Planctomycetes	203682|Planctomycetes	Q	HemY domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_7743925_8	871968.DESME_02010	2.298e-33	141.0	COG2931@1|root,COG2931@2|Bacteria	2|Bacteria	Q	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	-	-	-	-	-	-	-	-	-	PATR
HKD3_k127_7790144_1	497964.CfE428DRAFT_2922	3.997e-95	319.0	COG1947@1|root,COG1947@2|Bacteria,46SV6@74201|Verrucomicrobia	74201|Verrucomicrobia	I	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol	ispE	-	2.7.1.148	ko:K00919	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05634	RC00002,RC01439	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
HKD3_k127_7790144_4	671143.DAMO_2553	1.848e-60	216.0	COG0284@1|root,COG0284@2|Bacteria,2NQYX@2323|unclassified Bacteria	2|Bacteria	F	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)	pyrF	GO:0003674,GO:0003824,GO:0004590,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019856,GO:0034641,GO:0034654,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.1.23	ko:K01591	ko00240,ko01100,map00240,map01100	M00051	R00965	RC00409	ko00000,ko00001,ko00002,ko01000	-	-	iECO103_1326.ECO103_1444,iECSF_1327.ECSF_1264,iSFV_1184.SFV_1294,iSF_1195.SF1285,iSFxv_1172.SFxv_1457,iS_1188.S1368,ic_1306.c1750	OMPdecase
HKD3_k127_7790144_7	497964.CfE428DRAFT_1799	3.239e-41	162.0	COG0095@1|root,COG0095@2|Bacteria,46T01@74201|Verrucomicrobia	74201|Verrucomicrobia	H	Biotin/lipoate A/B protein ligase family	lplA	-	6.3.1.20	ko:K03800	ko00785,ko01100,map00785,map01100	-	R07770,R07771,R11143	RC00043,RC00070,RC00090,RC00992,RC02896	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB
HKD3_k127_7790144_0	497964.CfE428DRAFT_2060	1.166e-106	357.0	COG0142@1|root,COG0142@2|Bacteria,46SKW@74201|Verrucomicrobia	74201|Verrucomicrobia	H	Belongs to the FPP GGPP synthase family	-	-	2.5.1.90	ko:K02523	ko00900,ko01110,map00900,map01110	-	R09248	RC00279	ko00000,ko00001,ko01000,ko01006	-	-	-	polyprenyl_synt
HKD3_k127_7790144_2	497964.CfE428DRAFT_2046	2.895e-92	308.0	COG2003@1|root,COG2003@2|Bacteria,46STQ@74201|Verrucomicrobia	74201|Verrucomicrobia	L	RadC-like JAB domain	-	-	-	ko:K03630	-	-	-	-	ko00000	-	-	-	RadC
HKD3_k127_7790144_3	497964.CfE428DRAFT_2044	1.909e-83	285.0	COG1043@1|root,COG1043@2|Bacteria,46SQN@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	-	-	2.3.1.129	ko:K00677	ko00540,ko01100,ko01503,map00540,map01100,map01503	M00060	R04567	RC00039,RC00055	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Acetyltransf_11,Hexapep
HKD3_k127_7790144_8	529709.PYCH_04490	1.521e-12	71.0	COG1977@1|root,arCOG00536@2157|Archaea,2XZ69@28890|Euryarchaeota,244I1@183968|Thermococci	183968|Thermococci	H	ThiS family	-	-	-	ko:K03636	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
HKD3_k127_7790144_5	497964.CfE428DRAFT_6292	1.431e-59	211.0	COG0634@1|root,COG0634@2|Bacteria,46T02@74201|Verrucomicrobia	74201|Verrucomicrobia	F	Belongs to the purine pyrimidine phosphoribosyltransferase family	hpt	-	2.4.2.8	ko:K00760	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	-	R00190,R01132,R01229,R02142,R08237,R08238,R08245	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	Pribosyltran
HKD3_k127_7790144_6	1396141.BATP01000004_gene5893	6.411e-56	199.0	COG0432@1|root,COG0432@2|Bacteria,46V31@74201|Verrucomicrobia,2IUFK@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Uncharacterised protein family UPF0047	-	-	-	-	-	-	-	-	-	-	-	-	UPF0047
HKD3_k127_7908038_2	395965.Msil_2683	1.239e-36	143.0	COG3829@1|root,COG4191@1|root,COG3829@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TR8X@28211|Alphaproteobacteria,3NAFU@45404|Beijerinckiaceae	28211|Alphaproteobacteria	T	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_4,PAS_8,PAS_9
HKD3_k127_7908038_0	497964.CfE428DRAFT_4403	7.478e-59	212.0	COG4566@1|root,COG4566@2|Bacteria,46V65@74201|Verrucomicrobia	74201|Verrucomicrobia	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HKD3_k127_7908038_3	1278073.MYSTI_04028	1.521e-20	96.0	COG4566@1|root,COG4566@2|Bacteria,1N6WR@1224|Proteobacteria,43AI7@68525|delta/epsilon subdivisions,2X5YF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HKD3_k127_7908038_4	1396418.BATQ01000106_gene5302	1.788e-18	89.0	COG4566@1|root,COG4566@2|Bacteria,46Z3N@74201|Verrucomicrobia,2IW9Z@203494|Verrucomicrobiae	203494|Verrucomicrobiae	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
HKD3_k127_7908038_6	481448.Minf_0369	5.316e-08	64.0	COG3637@1|root,COG3637@2|Bacteria,46Z1R@74201|Verrucomicrobia,37H2D@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	M	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_7908038_1	1403819.BATR01000009_gene303	1.815e-38	159.0	COG2067@1|root,COG2067@2|Bacteria	2|Bacteria	I	long-chain fatty acid transporting porin activity	-	-	-	ko:K06076	-	-	-	-	ko00000,ko02000	1.B.9	-	-	Phenol_MetA_deg
HKD3_k127_7908038_7	1454004.AW11_02111	1.6e-06	53.0	28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria	1224|Proteobacteria	S	Protein of unknown function (DUF3604)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3604
HKD3_k127_7925579_0	497964.CfE428DRAFT_3980	1.556e-81	276.0	COG2908@1|root,COG2908@2|Bacteria,46U19@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Calcineurin-like phosphoesterase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
HKD3_k127_7934317_1	497964.CfE428DRAFT_1447	1.227e-134	433.0	COG0265@1|root,COG0823@1|root,COG2234@1|root,COG0265@2|Bacteria,COG0823@2|Bacteria,COG2234@2|Bacteria,46T85@74201|Verrucomicrobia	74201|Verrucomicrobia	OU	PA domain	-	-	-	-	-	-	-	-	-	-	-	-	PA,PD40,PDZ_2,Peptidase_M28
HKD3_k127_7934317_0	497964.CfE428DRAFT_6713	1.093e-150	496.0	COG3961@1|root,COG3961@2|Bacteria,46UYW@74201|Verrucomicrobia	74201|Verrucomicrobia	GH	Thiamine pyrophosphate enzyme, central domain	-	-	-	-	-	-	-	-	-	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
HKD3_k127_7934317_2	1396141.BATP01000032_gene4428	7.917e-10	63.0	28SRY@1|root,2ZF1S@2|Bacteria,46WN4@74201|Verrucomicrobia,2IWDV@203494|Verrucomicrobiae	203494|Verrucomicrobiae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_7946470_0	452637.Oter_1454	5.808e-214	676.0	COG0841@1|root,COG0841@2|Bacteria,46SER@74201|Verrucomicrobia	74201|Verrucomicrobia	V	AcrB/AcrD/AcrF family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
HKD3_k127_7946470_1	1403819.BATR01000098_gene3272	3.791e-83	287.0	28P28@1|root,2ZBYC@2|Bacteria,46V4V@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_7952870_1	1449126.JQKL01000014_gene2976	2.276e-29	123.0	COG0547@1|root,COG0547@2|Bacteria,1TP8U@1239|Firmicutes,247WY@186801|Clostridia,267KV@186813|unclassified Clostridiales	186801|Clostridia	E	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)	trpD	-	2.4.2.18,4.1.3.27	ko:K00766,ko:K13497	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R00985,R00986,R01073	RC00010,RC00440,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3
HKD3_k127_7952870_0	1123354.AUDR01000017_gene4	1.136e-56	210.0	COG0134@1|root,COG0134@2|Bacteria,1MW5K@1224|Proteobacteria,2VIN7@28216|Betaproteobacteria,1KREE@119069|Hydrogenophilales	119069|Hydrogenophilales	E	Indole-3-glycerol phosphate synthase	trpC	-	4.1.1.48	ko:K01609	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03508	RC00944	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPS
HKD3_k127_8187952_0	1183438.GKIL_3614	1.269e-74	266.0	COG2706@1|root,COG2706@2|Bacteria	2|Bacteria	G	6-phosphogluconolactonase activity	-	-	-	-	-	-	-	-	-	-	-	-	Lactonase
HKD3_k127_8187952_1	1183438.GKIL_0413	3.024e-54	207.0	COG2911@1|root,COG5295@1|root,COG2911@2|Bacteria,COG5295@2|Bacteria	2|Bacteria	UW	Hep Hag repeat protein	-	GO:0005575,GO:0005576	-	-	-	-	-	-	-	-	-	-	CBM_3,CHAT,CHU_C,Cohesin,Peptidase_S74
HKD3_k127_8187952_2	1242864.D187_000900	1.109e-35	150.0	COG0526@1|root,COG0526@2|Bacteria,1NH1D@1224|Proteobacteria,42XJ2@68525|delta/epsilon subdivisions,2X5GC@28221|Deltaproteobacteria,2YUZX@29|Myxococcales	28221|Deltaproteobacteria	CO	Thioredoxin-like	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_7
HKD3_k127_8187952_3	378806.STAUR_0972	5.097e-07	53.0	COG0526@1|root,COG0526@2|Bacteria,1QYGQ@1224|Proteobacteria,43CCZ@68525|delta/epsilon subdivisions,2X7NU@28221|Deltaproteobacteria,2Z3H8@29|Myxococcales	28221|Deltaproteobacteria	CO	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_7
HKD3_k127_835087_0	452637.Oter_4089	0.0	1241.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,46TNN@74201|Verrucomicrobia,3K7A5@414999|Opitutae	414999|Opitutae	G	Belongs to the PEP-utilizing enzyme family	-	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
HKD3_k127_835087_3	1191523.MROS_1289	1.222e-13	72.0	COG1943@1|root,COG1943@2|Bacteria	2|Bacteria	L	Transposase	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
HKD3_k127_835087_2	247490.KSU1_D0171	5.465e-34	132.0	COG1943@1|root,COG1943@2|Bacteria,2J0GJ@203682|Planctomycetes	203682|Planctomycetes	L	Transposase IS200 like	-	-	-	-	-	-	-	-	-	-	-	-	Y1_Tnp
HKD3_k127_835087_1	321327.CYA_2098	3.985e-216	687.0	COG0403@1|root,COG1003@1|root,COG0403@2|Bacteria,COG1003@2|Bacteria,1G1HW@1117|Cyanobacteria,1GYMF@1129|Synechococcus	1117|Cyanobacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvP	-	1.4.4.2	ko:K00281	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko00002,ko01000	-	-	-	GDC-P
HKD3_k127_8456138_0	497964.CfE428DRAFT_3303	2.638e-249	779.0	COG0504@1|root,COG0504@2|Bacteria,46S8K@74201|Verrucomicrobia	74201|Verrucomicrobia	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_synth_N,GATase
HKD3_k127_8456138_1	497964.CfE428DRAFT_3304	2.159e-83	286.0	COG1212@1|root,COG1212@2|Bacteria,46SS4@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria	kdsB	-	2.7.7.38	ko:K00979	ko00540,ko01100,map00540,map01100	M00063	R03351,R11396	RC00152,RC00910	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CTP_transf_3
HKD3_k127_8456138_3	234267.Acid_7157	1.947e-50	184.0	COG0241@1|root,COG0241@2|Bacteria,3Y5QH@57723|Acidobacteria	57723|Acidobacteria	E	Polynucleotide kinase 3 phosphatase	-	-	3.1.3.82,3.1.3.83	ko:K03273	ko00540,ko01100,map00540,map01100	M00064	R05647,R09771	RC00017	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hydrolase_like
HKD3_k127_8456138_2	1396418.BATQ01000015_gene4297	1.349e-69	244.0	COG2870@1|root,COG2870@2|Bacteria,46T1J@74201|Verrucomicrobia,2IVXQ@203494|Verrucomicrobiae	203494|Verrucomicrobiae	M	pfkB family carbohydrate kinase	-	-	2.7.1.167,2.7.7.70	ko:K03272	ko00540,ko01100,map00540,map01100	M00064	R05644,R05646	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	PfkB
HKD3_k127_8484478_1	671143.DAMO_0766	9.744e-70	241.0	COG0493@1|root,COG1143@1|root,COG0493@2|Bacteria,COG1143@2|Bacteria,2NNUW@2323|unclassified Bacteria	2|Bacteria	C	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	pcmB	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6,1.97.1.9	ko:K03388,ko:K12527	ko00450,ko00680,ko01100,ko01120,ko01200,map00450,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R07229,R11928,R11931,R11943,R11944	RC00011,RC02420	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_20,FlpD,Pyr_redox_2,Pyr_redox_3
HKD3_k127_8484478_3	246197.MXAN_1016	2.232e-10	65.0	COG2863@1|root,COG2863@2|Bacteria,1RKUY@1224|Proteobacteria,43BWX@68525|delta/epsilon subdivisions,2X77P@28221|Deltaproteobacteria,2Z1IB@29|Myxococcales	28221|Deltaproteobacteria	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
HKD3_k127_8484478_0	1396141.BATP01000041_gene2218	1.153e-161	523.0	COG0019@1|root,COG0019@2|Bacteria,46SC5@74201|Verrucomicrobia,2ITWM@203494|Verrucomicrobiae	203494|Verrucomicrobiae	E	Pyridoxal-dependent decarboxylase, pyridoxal binding domain	-	-	4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
HKD3_k127_8484478_2	497964.CfE428DRAFT_5652	2.161e-25	111.0	2A8AI@1|root,30XBY@2|Bacteria,46SPH@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_8492771_0	204669.Acid345_1624	0.0	1256.0	COG4447@1|root,COG4447@2|Bacteria,3Y2SN@57723|Acidobacteria,2JIF7@204432|Acidobacteriia	204432|Acidobacteriia	S	Sortilin, neurotensin receptor 3,	-	-	-	-	-	-	-	-	-	-	-	-	Sortilin-Vps10
HKD3_k127_8492771_2	215803.DB30_4561	3.214e-69	248.0	COG0451@1|root,COG0451@2|Bacteria,1RBSM@1224|Proteobacteria,42XUG@68525|delta/epsilon subdivisions,2WTSY@28221|Deltaproteobacteria,2YX8Q@29|Myxococcales	28221|Deltaproteobacteria	GM	NAD dependent epimerase/dehydratase family	-	-	1.3.1.45	ko:K05281	ko00943,ko01110,map00943,map01110	-	R06562,R06563,R07747,R07751	RC00805	ko00000,ko00001,ko01000	-	-	-	Epimerase
HKD3_k127_8492771_3	411477.PARMER_02289	4.175e-45	170.0	COG0225@1|root,COG0229@1|root,COG0225@2|Bacteria,COG0229@2|Bacteria,4NMAJ@976|Bacteroidetes,2FNTE@200643|Bacteroidia,22XGW@171551|Porphyromonadaceae	976|Bacteroidetes	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	msrA	-	1.8.4.11,1.8.4.12	ko:K12267	-	-	-	-	ko00000,ko01000	-	-	-	PMSR,SelR
HKD3_k127_8492771_1	459495.SPLC1_S101730	6.508e-70	241.0	COG0317@1|root,COG0317@2|Bacteria,1G0F8@1117|Cyanobacteria,1HA1X@1150|Oscillatoriales	1117|Cyanobacteria	KT	PFAM Metal-dependent phosphohydrolase, HD	-	-	2.7.6.5	ko:K00951	ko00230,map00230	-	R00429	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	HD_4
HKD3_k127_8498038_36	497964.CfE428DRAFT_3838	1.758e-41	168.0	COG2911@1|root,COG2911@2|Bacteria,46TSK@74201|Verrucomicrobia	74201|Verrucomicrobia	S	TamB, inner membrane protein subunit of TAM complex	-	-	-	-	-	-	-	-	-	-	-	-	TamB
HKD3_k127_8498038_48	243231.GSU1897	1.581e-12	76.0	COG0775@1|root,COG0775@2|Bacteria,1Q1C0@1224|Proteobacteria,43EX0@68525|delta/epsilon subdivisions,2WRFZ@28221|Deltaproteobacteria,43V4A@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	PFAM purine or other phosphorylase family 1	-	-	3.2.2.9	ko:K01243	ko00270,ko01100,ko01230,map00270,map01100,map01230	M00034,M00609	R00194,R01401	RC00063,RC00318	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
HKD3_k127_8498038_19	497964.CfE428DRAFT_1013	6.471e-108	357.0	COG0053@1|root,COG0053@2|Bacteria,46SPJ@74201|Verrucomicrobia	74201|Verrucomicrobia	P	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,ZT_dimer
HKD3_k127_8498038_20	497964.CfE428DRAFT_1012	8.426e-107	357.0	COG0604@1|root,COG0604@2|Bacteria,46UF3@74201|Verrucomicrobia	74201|Verrucomicrobia	C	Zinc-binding dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
HKD3_k127_8498038_4	1123073.KB899242_gene1321	2.649e-232	732.0	COG0457@1|root,COG0457@2|Bacteria,1N0A9@1224|Proteobacteria,1RZSZ@1236|Gammaproteobacteria,1XA6G@135614|Xanthomonadales	135614|Xanthomonadales	S	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_8498038_35	1396141.BATP01000040_gene2174	1.409e-42	167.0	COG3315@1|root,COG3315@2|Bacteria	2|Bacteria	Q	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	LCM,Methyltransf_19
HKD3_k127_8498038_12	1408445.JHXP01000014_gene1418	6.217e-143	468.0	COG0277@1|root,COG0277@2|Bacteria,1MV1Q@1224|Proteobacteria,1RSC3@1236|Gammaproteobacteria,1JDAH@118969|Legionellales	118969|Legionellales	C	D-arabinono-1,4-lactone oxidase	-	-	-	-	-	-	-	-	-	-	-	-	ALO,FAD_binding_4
HKD3_k127_8498038_13	452637.Oter_2782	4.235e-133	436.0	COG0501@1|root,COG0501@2|Bacteria,46TVV@74201|Verrucomicrobia,3K72R@414999|Opitutae	414999|Opitutae	O	Peptidase M48	-	-	3.4.24.84	ko:K06013	ko00900,ko01130,map00900,map01130	-	R09845	RC00141	ko00000,ko00001,ko01000,ko01002,ko04147	-	-	-	Peptidase_M48,Peptidase_M48_N
HKD3_k127_8498038_18	926550.CLDAP_37850	6.726e-114	379.0	COG0665@1|root,COG0665@2|Bacteria,2G6XM@200795|Chloroflexi	200795|Chloroflexi	E	FAD dependent oxidoreductase	-	-	1.5.3.1	ko:K00301	ko00260,ko01100,map00260,map01100	-	R00610	RC00060,RC00557	ko00000,ko00001,ko01000	-	-	-	DAO
HKD3_k127_8498038_30	497964.CfE428DRAFT_1418	4.125e-53	192.0	COG1847@1|root,COG1847@2|Bacteria,46VYD@74201|Verrucomicrobia	74201|Verrucomicrobia	S	R3H domain	-	-	-	-	-	-	-	-	-	-	-	-	R3H
HKD3_k127_8498038_17	497964.CfE428DRAFT_1419	5.037e-118	400.0	COG0706@1|root,COG0706@2|Bacteria,46SHI@74201|Verrucomicrobia	74201|Verrucomicrobia	U	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins	yidC	-	-	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03029	2.A.9	-	-	60KD_IMP,YidC_periplas
HKD3_k127_8498038_40	1396418.BATQ01000150_gene2227	7.349e-26	109.0	COG0759@1|root,COG0759@2|Bacteria,46W3D@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Could be involved in insertion of integral membrane proteins into the membrane	-	-	-	ko:K08998	-	-	-	-	ko00000	-	-	-	Haemolytic
HKD3_k127_8498038_44	497964.CfE428DRAFT_1421	9.446e-22	102.0	COG0594@1|root,COG0594@2|Bacteria,46WEU@74201|Verrucomicrobia	74201|Verrucomicrobia	J	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme	-	-	3.1.26.5	ko:K03536	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Ribonuclease_P
HKD3_k127_8498038_9	240016.ABIZ01000001_gene5947	1.042e-164	525.0	COG0686@1|root,COG0686@2|Bacteria,46S7U@74201|Verrucomicrobia,2ITXS@203494|Verrucomicrobiae	203494|Verrucomicrobiae	E	Alanine dehydrogenase/PNT, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
HKD3_k127_8498038_32	497964.CfE428DRAFT_0656	5.685e-48	179.0	COG1678@1|root,COG1678@2|Bacteria,46VUF@74201|Verrucomicrobia	74201|Verrucomicrobia	K	Uncharacterized ACR, COG1678	-	-	-	ko:K07735	-	-	-	-	ko00000,ko03000	-	-	-	DUF179
HKD3_k127_8498038_47	1519464.HY22_14065	2.375e-14	81.0	2DDRS@1|root,2ZJ0Y@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF4230)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4230
HKD3_k127_8498038_1	1121468.AUBR01000017_gene2394	0.0	1049.0	COG0587@1|root,COG0587@2|Bacteria,1TPYG@1239|Firmicutes,247U0@186801|Clostridia,42EPB@68295|Thermoanaerobacterales	186801|Clostridia	L	TIGRFAM DNA polymerase III, alpha subunit	dnaE	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
HKD3_k127_8498038_31	497964.CfE428DRAFT_5132	9.232e-53	188.0	COG0347@1|root,COG0347@2|Bacteria,46VXS@74201|Verrucomicrobia	74201|Verrucomicrobia	E	Belongs to the P(II) protein family	-	-	-	-	-	-	-	-	-	-	-	-	P-II
HKD3_k127_8498038_5	478741.JAFS01000001_gene1775	1.213e-221	695.0	COG0174@1|root,COG0174@2|Bacteria,46UCU@74201|Verrucomicrobia,37FVD@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	E	Glutamine synthetase, catalytic domain	glnA	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
HKD3_k127_8498038_50	243090.RB6395	4.21e-09	60.0	COG0457@1|root,COG0457@2|Bacteria,2IZWD@203682|Planctomycetes	203682|Planctomycetes	KLT	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_10,TPR_16,TPR_2,TPR_8
HKD3_k127_8498038_26	1403819.BATR01000114_gene3946	9.925e-66	233.0	COG0288@1|root,COG0288@2|Bacteria,46ST9@74201|Verrucomicrobia,2IWJF@203494|Verrucomicrobiae	203494|Verrucomicrobiae	P	Carbonic anhydrase	-	-	-	-	-	-	-	-	-	-	-	-	Pro_CA
HKD3_k127_8498038_21	118166.JH976537_gene4259	8.19e-101	334.0	COG3217@1|root,COG3217@2|Bacteria,1G2HY@1117|Cyanobacteria	1117|Cyanobacteria	S	MOSC domain containing protein	-	-	-	ko:K07140	-	-	-	-	ko00000	-	-	-	MOSC,MOSC_N
HKD3_k127_8498038_7	497964.CfE428DRAFT_0969	3.185e-203	642.0	COG0477@1|root,COG2814@2|Bacteria,46TKN@74201|Verrucomicrobia	74201|Verrucomicrobia	EGP	Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family	-	-	-	-	-	-	-	-	-	-	-	-	Sugar_tr
HKD3_k127_8498038_33	497964.CfE428DRAFT_4353	3.438e-46	173.0	COG1514@1|root,COG1514@2|Bacteria,46SZP@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester	-	-	3.1.4.58	ko:K01975	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	LigT_PEase
HKD3_k127_8498038_23	211165.AJLN01000100_gene4217	3.964e-92	314.0	COG0300@1|root,COG0300@2|Bacteria,1G1AT@1117|Cyanobacteria,1JKU3@1189|Stigonemataceae	1117|Cyanobacteria	S	Fungal family of unknown function (DUF1776)	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HKD3_k127_8498038_27	497964.CfE428DRAFT_6678	5.946e-56	201.0	COG0691@1|root,COG0691@2|Bacteria,46VGJ@74201|Verrucomicrobia	74201|Verrucomicrobia	O	the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA	smpB	-	-	ko:K03664	-	-	-	-	ko00000	-	-	-	SmpB
HKD3_k127_8498038_45	497964.CfE428DRAFT_6679	5.085e-21	96.0	COG1758@1|root,COG1758@2|Bacteria,46T94@74201|Verrucomicrobia	74201|Verrucomicrobia	K	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits	-	-	2.7.7.6	ko:K03060	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb6
HKD3_k127_8498038_41	497964.CfE428DRAFT_3727	9.866e-26	113.0	2FH6M@1|root,34912@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF4203)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4203
HKD3_k127_8498038_49	107636.JQNK01000009_gene1767	2.143e-09	63.0	2DTI2@1|root,33KFK@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_8498038_11	1499498.EV05_0280	2.167e-154	497.0	COG1304@1|root,COG1304@2|Bacteria,1G32Y@1117|Cyanobacteria,1MM3B@1212|Prochloraceae	1117|Cyanobacteria	C	L-lactate dehydrogenase	lldD	-	1.1.2.3,1.1.3.46	ko:K00101,ko:K16422	ko00261,ko00620,ko01055,ko01100,ko01130,map00261,map00620,map01055,map01100,map01130	-	R00196,R06633	RC00044,RC00240	ko00000,ko00001,ko01000	-	-	-	FMN_dh
HKD3_k127_8498038_3	497964.CfE428DRAFT_2061	4.317e-234	734.0	COG0138@1|root,COG0138@2|Bacteria,46S5H@74201|Verrucomicrobia	74201|Verrucomicrobia	F	Bifunctional purine biosynthesis protein PurH	purH	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AICARFT_IMPCHas,MGS
HKD3_k127_8498038_25	497964.CfE428DRAFT_1756	3.391e-70	253.0	COG2207@1|root,COG2207@2|Bacteria,46T4M@74201|Verrucomicrobia	74201|Verrucomicrobia	K	helix_turn_helix, arabinose operon control protein	araC	-	-	-	-	-	-	-	-	-	-	-	HTH_18
HKD3_k127_8498038_15	1095769.CAHF01000006_gene1886	8.328e-133	430.0	28HGI@1|root,2Z7SC@2|Bacteria,1MWKC@1224|Proteobacteria,2VP5Q@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_8498038_37	497964.CfE428DRAFT_4673	5.251e-38	147.0	COG2172@1|root,COG2172@2|Bacteria	2|Bacteria	T	sigma factor antagonist activity	-	-	2.7.11.1	ko:K04757	-	-	-	-	ko00000,ko01000,ko01001,ko03021	-	-	-	GAF_2,HATPase_c_2,SpoIIE
HKD3_k127_8498038_10	497964.CfE428DRAFT_5370	2.3e-161	514.0	COG2255@1|root,COG2255@2|Bacteria,46SDS@74201|Verrucomicrobia	74201|Verrucomicrobia	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing	ruvB	-	3.6.4.12	ko:K03551	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvB_C,RuvB_N
HKD3_k127_8498038_39	235909.GK1718	5.579e-27	116.0	COG0500@1|root,COG2226@2|Bacteria,1V3HT@1239|Firmicutes,4HHUM@91061|Bacilli,1WGKT@129337|Geobacillus	91061|Bacilli	Q	SAM-dependent methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
HKD3_k127_8498038_53	268407.PWYN_17820	0.0006046	45.0	COG0500@1|root,COG2226@2|Bacteria,1V3HT@1239|Firmicutes,4HHUM@91061|Bacilli,26SSS@186822|Paenibacillaceae	91061|Bacilli	Q	(SAM)-dependent	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
HKD3_k127_8498038_24	661478.OP10G_1995	3.561e-86	301.0	COG0683@1|root,COG0683@2|Bacteria	2|Bacteria	E	ABC-type branched-chain amino acid transport systems, periplasmic component	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
HKD3_k127_8498038_14	497964.CfE428DRAFT_1008	4.667e-133	436.0	COG1570@1|root,COG1570@2|Bacteria,46SCN@74201|Verrucomicrobia	74201|Verrucomicrobia	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseA	-	3.1.11.6	ko:K03601	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_L,tRNA_anti_2
HKD3_k127_8498038_8	1396141.BATP01000046_gene1888	1.22e-194	634.0	COG0628@1|root,COG2203@1|root,COG0628@2|Bacteria,COG2203@2|Bacteria,46S5V@74201|Verrucomicrobia,2IVEK@203494|Verrucomicrobiae	203494|Verrucomicrobiae	T	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
HKD3_k127_8498038_6	452637.Oter_0622	9.165e-220	688.0	COG0160@1|root,COG0160@2|Bacteria,46TE8@74201|Verrucomicrobia,3KA3D@414999|Opitutae	2|Bacteria	H	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	dgdA	-	2.6.1.19,2.6.1.22	ko:K00823,ko:K07250	ko00250,ko00280,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00280,map00410,map00640,map00650,map01100,map01120	M00027	R00908,R01648,R04188	RC00006,RC00062,RC00160	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	APH,Aminotran_3,Peptidase_M23
HKD3_k127_8498038_28	497964.CfE428DRAFT_0420	4.072e-55	196.0	2AY99@1|root,31QBJ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_8498038_0	497964.CfE428DRAFT_1006	0.0	1108.0	COG0296@1|root,COG0296@2|Bacteria,46SH5@74201|Verrucomicrobia	74201|Verrucomicrobia	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position	glgB	-	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48
HKD3_k127_8498038_52	215803.DB30_1791	0.0001239	53.0	2EMUN@1|root,33FGZ@2|Bacteria,1NYFS@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_8498038_42	2074.JNYD01000015_gene4582	7.19e-24	109.0	COG3595@1|root,COG3595@2|Bacteria,2GWE4@201174|Actinobacteria	201174|Actinobacteria	S	Putative auto-transporter adhesin, head GIN domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF2807
HKD3_k127_8498038_38	273121.WS1743	4.993e-27	119.0	COG4238@1|root,COG4238@2|Bacteria,1N4E5@1224|Proteobacteria,42USX@68525|delta/epsilon subdivisions,2YQ09@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	M	major outer membrane lipoprotein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_8498038_29	1121472.AQWN01000004_gene775	6.208e-54	200.0	COG1994@1|root,COG1994@2|Bacteria,1TSA9@1239|Firmicutes,24CR6@186801|Clostridia,261RF@186807|Peptococcaceae	186801|Clostridia	S	PFAM Peptidase family M50	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_8498038_16	234267.Acid_7851	9.537e-131	441.0	COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,3Y6UN@57723|Acidobacteria	57723|Acidobacteria	K	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_8498038_22	234267.Acid_7851	2.106e-96	345.0	COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,3Y6UN@57723|Acidobacteria	57723|Acidobacteria	K	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_8498038_2	497964.CfE428DRAFT_2741	1.284e-241	754.0	COG0556@1|root,COG0556@2|Bacteria,46SF2@74201|Verrucomicrobia	74201|Verrucomicrobia	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	-	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
HKD3_k127_8503_12	1156937.MFUM_310039	9.582e-27	111.0	COG0724@1|root,COG0724@2|Bacteria,46VMU@74201|Verrucomicrobia,37HA9@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	S	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	-	-	-	-	-	-	-	-	-	-	-	-	RRM_1
HKD3_k127_8503_15	1396141.BATP01000059_gene2386	3.005e-23	102.0	COG0361@1|root,COG0361@2|Bacteria,46T5J@74201|Verrucomicrobia,2IUS9@203494|Verrucomicrobiae	203494|Verrucomicrobiae	J	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex	infA	-	-	ko:K02518	-	-	-	-	ko00000,ko03012	-	-	-	eIF-1a
HKD3_k127_8503_4	340.xcc-b100_0126	2.172e-139	454.0	COG2755@1|root,COG2755@2|Bacteria,1MXBN@1224|Proteobacteria,1RQJF@1236|Gammaproteobacteria,1X4T4@135614|Xanthomonadales	135614|Xanthomonadales	E	GDSL-like Lipase/Acylhydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
HKD3_k127_8503_19	96561.Dole_1061	3.036e-06	59.0	COG1073@1|root,COG1073@2|Bacteria,1RBV1@1224|Proteobacteria,42M9M@68525|delta/epsilon subdivisions,2WM64@28221|Deltaproteobacteria,2MJJ0@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Serine aminopeptidase, S33	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Hydrolase_4
HKD3_k127_8503_17	1535422.ND16A_1925	2.278e-08	66.0	COG1073@1|root,COG1073@2|Bacteria,1RBP3@1224|Proteobacteria,1S216@1236|Gammaproteobacteria,2Q5Y1@267889|Colwelliaceae	1236|Gammaproteobacteria	S	Dienelactone hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4
HKD3_k127_8503_7	331869.BAL199_00165	3.658e-72	255.0	COG1262@1|root,COG4249@1|root,COG1262@2|Bacteria,COG4249@2|Bacteria,1MXFD@1224|Proteobacteria,2TRW5@28211|Alphaproteobacteria,4BQPK@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	M	Caspase domain	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase,PG_binding_1,Peptidase_C14,SH3_3
HKD3_k127_8503_11	1396141.BATP01000039_gene1336	1.985e-40	155.0	COG1595@1|root,COG1595@2|Bacteria,46VX9@74201|Verrucomicrobia,2IUIG@203494|Verrucomicrobiae	203494|Verrucomicrobiae	K	Sigma-70, region 4	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD3_k127_8503_20	452637.Oter_0300	1.987e-05	55.0	COG5662@1|root,COG5662@2|Bacteria	2|Bacteria	K	AntiSigma factor	-	-	-	-	-	-	-	-	-	-	-	-	DUF3379
HKD3_k127_8503_16	1156937.MFUM_310045	8.332e-19	96.0	2CK2Q@1|root,30XDX@2|Bacteria,46X4H@74201|Verrucomicrobia,37HA6@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_8503_5	1089552.KI911559_gene3240	8.775e-106	352.0	COG4948@1|root,COG4948@2|Bacteria,1MW76@1224|Proteobacteria,2TR16@28211|Alphaproteobacteria,2JPK3@204441|Rhodospirillales	204441|Rhodospirillales	M	Belongs to the mandelate racemase muconate lactonizing enzyme family	-	-	5.1.1.20	ko:K19802	-	-	R10938	RC03309	ko00000,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
HKD3_k127_8503_1	1382359.JIAL01000001_gene1690	4.988e-190	614.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,3Y3ZP@57723|Acidobacteria,2JI7Y@204432|Acidobacteriia	204432|Acidobacteriia	EU	Dienelactone hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
HKD3_k127_8503_14	68570.DC74_6164	4.839e-26	113.0	COG0454@1|root,COG0454@2|Bacteria,2I4WW@201174|Actinobacteria	201174|Actinobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HKD3_k127_8503_9	1131269.AQVV01000065_gene1812	2.423e-53	192.0	COG0431@1|root,COG0431@2|Bacteria	2|Bacteria	S	FMN reductase (NADPH) activity	ssuE	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006568,GO:0006569,GO:0006576,GO:0006586,GO:0006725,GO:0006766,GO:0006767,GO:0006790,GO:0006805,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0008752,GO:0009056,GO:0009063,GO:0009072,GO:0009074,GO:0009111,GO:0009267,GO:0009308,GO:0009310,GO:0009410,GO:0009605,GO:0009970,GO:0009987,GO:0009991,GO:0010181,GO:0016043,GO:0016054,GO:0016491,GO:0016645,GO:0016646,GO:0019439,GO:0019694,GO:0019752,GO:0022607,GO:0031667,GO:0031668,GO:0031669,GO:0032553,GO:0032787,GO:0033554,GO:0034641,GO:0036094,GO:0042178,GO:0042221,GO:0042365,GO:0042402,GO:0042430,GO:0042436,GO:0042537,GO:0042594,GO:0043167,GO:0043168,GO:0043420,GO:0043421,GO:0043436,GO:0043933,GO:0044085,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044273,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046218,GO:0046306,GO:0046395,GO:0046483,GO:0046700,GO:0048037,GO:0050662,GO:0050896,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0051716,GO:0052873,GO:0055114,GO:0065003,GO:0070887,GO:0071466,GO:0071496,GO:0071704,GO:0071840,GO:0072329,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	1.5.1.38,1.5.1.45	ko:K00299,ko:K16902	ko00380,ko00740,ko00920,ko01100,map00380,map00740,map00920,map01100	-	R05706,R07210,R09517,R09520,R09748,R10206	RC00046,RC00126,RC01779,RC02556	ko00000,ko00001,ko01000	-	-	iAF1260.b0937,iB21_1397.B21_00948,iBWG_1329.BWG_0789,iE2348C_1286.E2348C_0930,iECBD_1354.ECBD_2658,iECB_1328.ECB_00941,iECDH10B_1368.ECDH10B_1007,iECDH1ME8569_1439.ECDH1ME8569_0888,iECD_1391.ECD_00941,iECIAI1_1343.ECIAI1_0978,iECO103_1326.ECO103_0982,iECW_1372.ECW_m1047,iEKO11_1354.EKO11_2893,iETEC_1333.ETEC_1005,iEcDH1_1363.EcDH1_2706,iEcE24377_1341.EcE24377A_1052,iEcHS_1320.EcHS_A1046,iEcolC_1368.EcolC_2659,iJO1366.b0937,iSB619.SA_RS01880,iSbBS512_1146.SbBS512_E2381,iUMNK88_1353.UMNK88_1092,iWFL_1372.ECW_m1047,iY75_1357.Y75_RS04870	FMN_red
HKD3_k127_8503_8	926560.KE387026_gene4310	3.528e-55	198.0	COG4101@1|root,COG4101@2|Bacteria	2|Bacteria	G	3-hydroxyanthranilate 3,4-dioxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HKD3_k127_8503_6	526222.Desal_2833	2.428e-78	265.0	COG2818@1|root,COG2818@2|Bacteria,1R9X5@1224|Proteobacteria,42QWV@68525|delta/epsilon subdivisions,2WMPT@28221|Deltaproteobacteria,2MB6B@213115|Desulfovibrionales	28221|Deltaproteobacteria	L	PFAM Methyladenine glycosylase	tag	-	3.2.2.20	ko:K01246	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Adenine_glyco
HKD3_k127_8503_10	452637.Oter_2243	9.066e-53	194.0	2EW42@1|root,33PH9@2|Bacteria,46U23@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_8503_2	452637.Oter_1325	5.831e-190	599.0	COG1180@1|root,COG1180@2|Bacteria	2|Bacteria	C	glycyl-radical enzyme activating activity	pflA	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
HKD3_k127_8503_0	497964.CfE428DRAFT_1406	2.848e-212	675.0	COG0038@1|root,COG0517@1|root,COG0038@2|Bacteria,COG0517@2|Bacteria,46S8W@74201|Verrucomicrobia	74201|Verrucomicrobia	P	PFAM CBS domain containing protein	-	-	-	ko:K03281	-	-	-	-	ko00000	2.A.49	-	-	CBS,Voltage_CLC
HKD3_k127_8503_3	450851.PHZ_c1809	1.149e-146	475.0	COG3104@1|root,COG3104@2|Bacteria,1MW6W@1224|Proteobacteria,2U15C@28211|Alphaproteobacteria,2KI09@204458|Caulobacterales	204458|Caulobacterales	E	POT family	-	-	-	ko:K03305	-	-	-	-	ko00000	2.A.17	-	-	PTR2
HKD3_k127_8510318_14	1123242.JH636434_gene5244	3.451e-93	328.0	2E55N@1|root,32ZYI@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_8510318_12	595460.RRSWK_03709	7.231e-115	398.0	COG0457@1|root,COG1807@1|root,COG0457@2|Bacteria,COG1807@2|Bacteria,2IYMF@203682|Planctomycetes	203682|Planctomycetes	M	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_11,TPR_16,TPR_2,TPR_8
HKD3_k127_8510318_5	1131269.AQVV01000048_gene2100	3.514e-145	484.0	COG0457@1|root,COG0457@2|Bacteria	1131269.AQVV01000048_gene2100|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_8510318_8	1131269.AQVV01000048_gene2100	9.355e-142	472.0	COG0457@1|root,COG0457@2|Bacteria	1131269.AQVV01000048_gene2100|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_8510318_13	706587.Desti_1819	1.077e-111	383.0	COG1807@1|root,COG1807@2|Bacteria,1R3XN@1224|Proteobacteria,42P5N@68525|delta/epsilon subdivisions,2WKH2@28221|Deltaproteobacteria,2MQ8W@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HKD3_k127_8510318_10	439235.Dalk_1883	8.33e-124	421.0	COG0457@1|root,COG0457@2|Bacteria,1RKQQ@1224|Proteobacteria,42T9T@68525|delta/epsilon subdivisions,2WPQ0@28221|Deltaproteobacteria,2MN67@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Tetratricopeptide TPR_2 repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2,TPR_16,TPR_2,TPR_8
HKD3_k127_8510318_9	497964.CfE428DRAFT_3489	2.392e-124	413.0	COG1785@1|root,COG1785@2|Bacteria,46TE7@74201|Verrucomicrobia	74201|Verrucomicrobia	P	Alkaline phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Alk_phosphatase
HKD3_k127_8510318_0	497964.CfE428DRAFT_0265	5.182e-232	728.0	COG0696@1|root,COG0696@2|Bacteria,46U4C@74201|Verrucomicrobia	74201|Verrucomicrobia	G	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate	gpmI	-	5.4.2.12	ko:K15633	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,Phosphodiest,iPGM_N
HKD3_k127_8510318_17	870187.Thini_1988	4.34e-47	184.0	COG3170@1|root,COG3170@2|Bacteria	2|Bacteria	NU	translation initiation factor activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF1631,DUF2510,PknH_C,TIR_2
HKD3_k127_8510318_20	1121914.AUDW01000024_gene108	2.392e-14	85.0	2DRCD@1|root,33B7A@2|Bacteria,1UKDM@1239|Firmicutes	1239|Firmicutes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_8510318_16	452637.Oter_0261	4.866e-48	182.0	2ECN9@1|root,336K5@2|Bacteria,46T7K@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_8510318_6	497964.CfE428DRAFT_0073	3.879e-142	459.0	COG0113@1|root,COG0113@2|Bacteria,46S91@74201|Verrucomicrobia	74201|Verrucomicrobia	H	Belongs to the ALAD family	hemB	-	4.2.1.24	ko:K01698	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00036	RC00918,RC01781	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ALAD
HKD3_k127_8510318_15	497964.CfE428DRAFT_5015	2.395e-69	243.0	COG1521@1|root,COG1521@2|Bacteria,46T0X@74201|Verrucomicrobia	74201|Verrucomicrobia	F	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis	coaX	-	2.7.1.33	ko:K03525	ko00770,ko01100,map00770,map01100	M00120	R02971,R03018,R04391	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Pan_kinase
HKD3_k127_8510318_22	1458427.BAWN01000019_gene1204	0.0001014	56.0	COG3063@1|root,COG3063@2|Bacteria,1MXPC@1224|Proteobacteria,2VNC8@28216|Betaproteobacteria,4AA8P@80864|Comamonadaceae	28216|Betaproteobacteria	NU	type IV pilus biogenesis stability protein PilW	pilF	-	-	ko:K02656	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	TPR_16,TPR_17,TPR_19,TPR_2,TPR_8
HKD3_k127_8510318_4	497964.CfE428DRAFT_0200	1.93e-167	532.0	COG2309@1|root,COG2309@2|Bacteria,46SAI@74201|Verrucomicrobia	74201|Verrucomicrobia	E	PFAM peptidase M29 aminopeptidase II	-	-	-	ko:K19689	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M29
HKD3_k127_8510318_11	497964.CfE428DRAFT_2039	1.437e-117	391.0	COG0144@1|root,COG0144@2|Bacteria,46TY0@74201|Verrucomicrobia	74201|Verrucomicrobia	J	16S rRNA methyltransferase RsmB/F	-	-	2.1.1.176	ko:K03500	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltr_RsmB-F,NusB
HKD3_k127_8510318_1	497964.CfE428DRAFT_2040	9.103e-205	644.0	COG1004@1|root,COG1004@2|Bacteria,46S6E@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	ugd	-	1.1.1.22	ko:K00012	ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100	M00014,M00129,M00361,M00362	R00286	RC00291	ko00000,ko00001,ko00002,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
HKD3_k127_8510318_2	497964.CfE428DRAFT_2041	4.496e-201	652.0	COG1452@1|root,COG1452@2|Bacteria,46SJX@74201|Verrucomicrobia	74201|Verrucomicrobia	M	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane	imp	-	-	ko:K04744	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	OstA_C
HKD3_k127_8510318_18	497964.CfE428DRAFT_6698	1.22e-44	168.0	COG0622@1|root,COG0622@2|Bacteria,46SXW@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Calcineurin-like phosphoesterase superfamily domain	-	-	-	ko:K07095	-	-	-	-	ko00000	-	-	-	Metallophos_2
HKD3_k127_8510318_7	1267534.KB906754_gene3776	5.32e-142	461.0	COG1005@1|root,COG1005@2|Bacteria,3Y6TS@57723|Acidobacteria,2JKJQ@204432|Acidobacteriia	204432|Acidobacteriia	C	NADH dehydrogenase	-	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
HKD3_k127_8510318_21	1123253.AUBD01000008_gene450	1.293e-11	71.0	COG0839@1|root,COG0839@2|Bacteria,1MWJV@1224|Proteobacteria,1S4ZA@1236|Gammaproteobacteria,1X5QE@135614|Xanthomonadales	135614|Xanthomonadales	C	Belongs to the complex I subunit 6 family	nuoJ	-	1.6.5.3	ko:K00339	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q3
HKD3_k127_8510318_19	1267534.KB906754_gene3774	1.478e-29	124.0	COG0713@1|root,COG0713@2|Bacteria,3Y835@57723|Acidobacteria,2JN5T@204432|Acidobacteriia	204432|Acidobacteriia	C	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L	-	-	1.6.5.3	ko:K00340	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q2
HKD3_k127_8510318_3	1267534.KB906754_gene3773	7.25e-184	588.0	COG1009@1|root,COG1009@2|Bacteria,3Y76V@57723|Acidobacteria,2JMJJ@204432|Acidobacteriia	204432|Acidobacteriia	CP	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus	-	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M,Proton_antipo_N
HKD3_k127_8519963_3	670307.HYPDE_38393	2.247e-55	199.0	COG0446@1|root,COG2146@1|root,COG0446@2|Bacteria,COG2146@2|Bacteria,1NR3M@1224|Proteobacteria,2TS0K@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.18.1.1	ko:K05297	ko00071,map00071	-	R02000	-	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_dim,Reductase_C,Rieske
HKD3_k127_8519963_4	1298858.AUEL01000011_gene5463	3.67e-32	127.0	2C3CF@1|root,32RRR@2|Bacteria,1MZUG@1224|Proteobacteria,2UC1Q@28211|Alphaproteobacteria,43KZA@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF3175)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3175
HKD3_k127_8519963_0	525904.Tter_1322	5.047e-140	452.0	COG0667@1|root,COG0667@2|Bacteria,2NPI2@2323|unclassified Bacteria	2|Bacteria	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
HKD3_k127_8519963_1	1121377.KB906402_gene3279	9.37e-112	364.0	COG1402@1|root,COG1402@2|Bacteria	2|Bacteria	I	creatininase	crnA_1	-	3.5.2.10	ko:K01470	ko00330,map00330	-	R01884	RC00615	ko00000,ko00001,ko01000	-	-	-	Creatininase
HKD3_k127_8519963_2	1303518.CCALI_00765	1.841e-84	290.0	COG0614@1|root,COG0614@2|Bacteria	2|Bacteria	P	abc-type fe3 -hydroxamate transport system, periplasmic component	-	-	-	ko:K02016	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	Peripla_BP_2
HKD3_k127_8521825_1	452637.Oter_0618	3.011e-186	595.0	COG3591@1|root,COG3591@2|Bacteria,46UUQ@74201|Verrucomicrobia	74201|Verrucomicrobia	E	Peptidase S46	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S46
HKD3_k127_8521825_3	204669.Acid345_1712	5.602e-101	346.0	COG1680@1|root,COG1680@2|Bacteria,3Y3WB@57723|Acidobacteria,2JJDH@204432|Acidobacteriia	204432|Acidobacteriia	V	PFAM beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
HKD3_k127_8521825_4	661478.OP10G_2718	1.75e-79	274.0	COG0412@1|root,COG0412@2|Bacteria	2|Bacteria	Q	carboxymethylenebutenolidase activity	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	AXE1,DLH
HKD3_k127_8521825_8	1121957.ATVL01000006_gene3201	1.99e-32	130.0	COG2259@1|root,COG2259@2|Bacteria,4PB3J@976|Bacteroidetes,47V4B@768503|Cytophagia	976|Bacteroidetes	S	DoxX	-	-	-	-	-	-	-	-	-	-	-	-	DoxX
HKD3_k127_8521825_2	1396418.BATQ01000119_gene3117	8.066e-106	352.0	COG1273@1|root,COG1273@2|Bacteria,46SB0@74201|Verrucomicrobia,2IVP3@203494|Verrucomicrobiae	203494|Verrucomicrobiae	L	Ku70/Ku80 beta-barrel domain	-	-	-	-	-	-	-	-	-	-	-	-	Ku
HKD3_k127_8521825_0	497964.CfE428DRAFT_3745	6.083e-191	603.0	COG0761@1|root,COG0761@2|Bacteria,46SAR@74201|Verrucomicrobia	74201|Verrucomicrobia	IM	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis	lytB	-	1.17.7.4	ko:K03527	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05884,R08210	RC01137,RC01487	ko00000,ko00001,ko00002,ko01000	-	-	-	LYTB
HKD3_k127_8521825_6	497964.CfE428DRAFT_3744	1.529e-64	229.0	COG1376@1|root,COG1376@2|Bacteria,46SUS@74201|Verrucomicrobia	74201|Verrucomicrobia	S	L,D-transpeptidase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	YkuD
HKD3_k127_8521825_5	497964.CfE428DRAFT_5924	1.744e-66	238.0	COG0470@1|root,COG0470@2|Bacteria,46T6T@74201|Verrucomicrobia	74201|Verrucomicrobia	L	DNA polymerase III, delta subunit	holB	-	2.7.7.7	ko:K02341	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNApol3-delta_C
HKD3_k127_8521825_7	497964.CfE428DRAFT_5925	2.266e-63	224.0	COG0125@1|root,COG0125@2|Bacteria,46ST1@74201|Verrucomicrobia	74201|Verrucomicrobia	F	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis	tmk	-	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylate_kin
HKD3_k127_8536243_16	497964.CfE428DRAFT_5925	3.744e-52	189.0	COG0125@1|root,COG0125@2|Bacteria,46ST1@74201|Verrucomicrobia	74201|Verrucomicrobia	F	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis	tmk	-	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylate_kin
HKD3_k127_8536243_18	497964.CfE428DRAFT_0837	4.188e-48	179.0	COG2947@1|root,COG2947@2|Bacteria,46VWG@74201|Verrucomicrobia	74201|Verrucomicrobia	S	EVE domain	-	-	-	-	-	-	-	-	-	-	-	-	EVE
HKD3_k127_8536243_14	497964.CfE428DRAFT_3551	2.5e-64	231.0	COG3233@1|root,COG3233@2|Bacteria,46VNN@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Uncharacterized protein conserved in bacteria (DUF2334)	-	-	-	ko:K06986	-	-	-	-	ko00000	-	-	-	DUF2334
HKD3_k127_8536243_1	497964.CfE428DRAFT_3549	6.899e-223	716.0	COG0438@1|root,COG0613@1|root,COG0438@2|Bacteria,COG0613@2|Bacteria,46SXZ@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
HKD3_k127_8536243_8	1121930.AQXG01000001_gene1099	1.289e-112	372.0	COG1171@1|root,COG1171@2|Bacteria,4NEY2@976|Bacteroidetes,1IUV5@117747|Sphingobacteriia	976|Bacteroidetes	E	Pyridoxal-phosphate dependent enzyme	ilvA	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HKD3_k127_8536243_3	420324.KI912007_gene8917	9.381e-151	486.0	COG0654@1|root,COG0654@2|Bacteria,1P1NX@1224|Proteobacteria,2TRZX@28211|Alphaproteobacteria,1JTU0@119045|Methylobacteriaceae	28211|Alphaproteobacteria	CH	FAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3
HKD3_k127_8536243_9	525904.Tter_2752	3.99e-96	324.0	COG2423@1|root,COG2423@2|Bacteria,2NPI5@2323|unclassified Bacteria	2|Bacteria	E	Ornithine cyclodeaminase/mu-crystallin family	-	-	1.4.1.1,1.5.1.25,4.3.1.12	ko:K01750,ko:K18258,ko:K19244	ko00250,ko00330,ko00430,ko01100,ko01110,ko01130,ko01230,map00250,map00330,map00430,map01100,map01110,map01130,map01230	-	R00396,R00671	RC00008,RC00354	ko00000,ko00001,ko01000,ko04147	-	-	-	OCD_Mu_crystall
HKD3_k127_8536243_12	1382359.JIAL01000001_gene597	8.991e-72	259.0	2EIHJ@1|root,33C8X@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_8536243_0	497964.CfE428DRAFT_1884	1.348e-254	803.0	COG1109@1|root,COG1109@2|Bacteria,46SB1@74201|Verrucomicrobia	74201|Verrucomicrobia	G	PFAM phosphoglucomutase phosphomannomutase alpha beta alpha domain I	-	-	5.4.2.2	ko:K01835	ko00010,ko00030,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00549	R00959,R01057,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
HKD3_k127_8536243_7	497964.CfE428DRAFT_1881	6.949e-121	407.0	COG0815@1|root,COG0815@2|Bacteria,46SPW@74201|Verrucomicrobia	74201|Verrucomicrobia	M	PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase	lnt	-	-	ko:K03820	-	-	-	-	ko00000,ko01000	-	GT2	-	CN_hydrolase
HKD3_k127_8536243_2	59374.Fisuc_0111	2.2e-157	503.0	COG3876@1|root,COG3876@2|Bacteria	2|Bacteria	G	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF1343
HKD3_k127_8536243_15	557599.MKAN_19080	2.431e-58	214.0	COG1656@1|root,COG1656@2|Bacteria,2GMQR@201174|Actinobacteria,23528@1762|Mycobacteriaceae	201174|Actinobacteria	S	Mut7-C ubiquitin	-	-	-	ko:K09122	-	-	-	-	ko00000	-	-	-	Mut7-C,Ub-Mut7C
HKD3_k127_8536243_5	1163407.UU7_05648	9.644e-139	465.0	COG1680@1|root,COG1680@2|Bacteria,1PQ2Z@1224|Proteobacteria,1SYR1@1236|Gammaproteobacteria,1XCSI@135614|Xanthomonadales	135614|Xanthomonadales	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
HKD3_k127_8536243_19	1500894.JQNN01000001_gene4471	3.972e-29	130.0	2AHCA@1|root,317P0@2|Bacteria,1PZ1J@1224|Proteobacteria,2W33I@28216|Betaproteobacteria	28216|Betaproteobacteria	S	S1/P1 Nuclease	-	-	-	-	-	-	-	-	-	-	-	-	S1-P1_nuclease
HKD3_k127_8536243_17	771875.Ferpe_1363	3.494e-50	182.0	COG1490@1|root,COG1490@2|Bacteria,2GCYQ@200918|Thermotogae	200918|Thermotogae	J	rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality	dtd	GO:0002161,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0051499,GO:0051500,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360	-	ko:K07560	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Tyr_Deacylase
HKD3_k127_8536243_4	404380.Gbem_1114	1.16e-140	469.0	COG0457@1|root,COG0457@2|Bacteria,1NNJ6@1224|Proteobacteria,42PBD@68525|delta/epsilon subdivisions,2WKWJ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Tetratricopeptide TPR_2 repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2,TPR_1,TPR_11,TPR_16,TPR_17,TPR_2,TPR_8
HKD3_k127_8536243_10	234267.Acid_2317	4.659e-82	284.0	COG1171@1|root,COG1171@2|Bacteria,3Y2RI@57723|Acidobacteria	57723|Acidobacteria	E	beta' subunit	-	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP,Thr_dehydrat_C
HKD3_k127_8536243_6	622637.KE124772_gene80	1.669e-121	391.0	COG0450@1|root,COG0450@2|Bacteria,1MX2B@1224|Proteobacteria,2TT09@28211|Alphaproteobacteria,36ZM7@31993|Methylocystaceae	28211|Alphaproteobacteria	O	C-terminal domain of 1-Cys peroxiredoxin	MA20_35715	-	-	-	-	-	-	-	-	-	-	-	1-cysPrx_C,AhpC-TSA
HKD3_k127_8536243_11	237368.SCABRO_00637	5.177e-79	271.0	COG3228@1|root,COG3228@2|Bacteria,2IZES@203682|Planctomycetes	203682|Planctomycetes	S	Belongs to the MtfA family	-	-	-	ko:K09933	-	-	-	-	ko00000,ko01002	-	-	-	Peptidase_M90,SEC-C
HKD3_k127_8536243_13	574087.Acear_1028	3.32e-65	237.0	COG0079@1|root,COG0079@2|Bacteria,1TPUV@1239|Firmicutes,24837@186801|Clostridia,3WA8M@53433|Halanaerobiales	186801|Clostridia	E	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily	hisC	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
HKD3_k127_8546436_10	1294142.CINTURNW_1637	2.863e-10	62.0	COG1970@1|root,COG1970@2|Bacteria,1VA14@1239|Firmicutes,24JAB@186801|Clostridia,36IZV@31979|Clostridiaceae	186801|Clostridia	M	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell	mscL	-	-	ko:K03282	-	-	-	-	ko00000,ko02000	1.A.22.1	-	-	MscL
HKD3_k127_8546436_0	497964.CfE428DRAFT_5324	0.0	1247.0	COG0495@1|root,COG0495@2|Bacteria,46SF4@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
HKD3_k127_8546436_6	497964.CfE428DRAFT_5323	1.522e-57	206.0	COG0127@1|root,COG0127@2|Bacteria,46SZ5@74201|Verrucomicrobia	74201|Verrucomicrobia	F	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions	-	-	3.6.1.66	ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000	-	-	-	Ham1p_like
HKD3_k127_8546436_8	481448.Minf_2323	8.182e-29	120.0	COG0848@1|root,COG0848@2|Bacteria,46W6Q@74201|Verrucomicrobia,37H8K@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	U	Biopolymer transport protein ExbD/TolR	-	-	-	ko:K03559	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	ExbD
HKD3_k127_8546436_11	589865.DaAHT2_1557	2.034e-06	58.0	COG0810@1|root,COG0810@2|Bacteria,1MZPX@1224|Proteobacteria,42VSU@68525|delta/epsilon subdivisions,2WR9P@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Gram-negative bacterial TonB protein C-terminal	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	TonB_C
HKD3_k127_8546436_7	481448.Minf_2323	5.496e-29	121.0	COG0848@1|root,COG0848@2|Bacteria,46W6Q@74201|Verrucomicrobia,37H8K@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	U	Biopolymer transport protein ExbD/TolR	-	-	-	ko:K03559	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	ExbD
HKD3_k127_8546436_4	478741.JAFS01000002_gene962	2.673e-66	241.0	COG0811@1|root,COG0811@2|Bacteria,46VD2@74201|Verrucomicrobia,37H3W@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	U	MotA/TolQ/ExbB proton channel family	-	-	-	ko:K03561	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	MotA_ExbB
HKD3_k127_8546436_5	871963.Desdi_2132	4.509e-58	212.0	COG0179@1|root,COG0179@2|Bacteria,1TQDQ@1239|Firmicutes,248AJ@186801|Clostridia,263G2@186807|Peptococcaceae	186801|Clostridia	Q	2-keto-4-pentenoate hydratase 2-oxohepta-3-ene-1,7-dioic acid hydratase	-	-	-	-	-	-	-	-	-	-	-	-	DUF2437,FAA_hydrolase
HKD3_k127_8546436_9	349741.Amuc_1920	6.986e-28	124.0	COG3698@1|root,COG3698@2|Bacteria,46W6D@74201|Verrucomicrobia,2IUTV@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Phosphodiester glycosidase	-	-	-	-	-	-	-	-	-	-	-	-	NAGPA
HKD3_k127_8546436_3	1122604.JONR01000031_gene1279	5.57e-118	404.0	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1T5SE@1236|Gammaproteobacteria,1XDE6@135614|Xanthomonadales	135614|Xanthomonadales	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_19
HKD3_k127_8546436_2	497964.CfE428DRAFT_2087	1.173e-130	423.0	COG0500@1|root,COG0640@1|root,COG0640@2|Bacteria,COG2226@2|Bacteria,46SDC@74201|Verrucomicrobia	74201|Verrucomicrobia	KQ	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_5,Methyltransf_11,Methyltransf_31
HKD3_k127_8546436_1	497964.CfE428DRAFT_2088	3.351e-168	533.0	COG0192@1|root,COG0192@2|Bacteria,46S4V@74201|Verrucomicrobia	74201|Verrucomicrobia	H	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme	metK	-	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
HKD3_k127_8569401_3	1156935.QWE_13573	1.884e-12	74.0	COG2373@1|root,COG2373@2|Bacteria,1QXEG@1224|Proteobacteria,2TX94@28211|Alphaproteobacteria,4BNYF@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Animal haem peroxidase	-	-	-	-	-	-	-	-	-	-	-	-	An_peroxidase
HKD3_k127_8569401_2	1286093.C266_07457	3.111e-22	101.0	COG2146@1|root,COG2146@2|Bacteria,1N72F@1224|Proteobacteria,2VTX8@28216|Betaproteobacteria,1K7S5@119060|Burkholderiaceae	28216|Betaproteobacteria	P	rieske 2fe-2s	-	-	-	-	-	-	-	-	-	-	-	-	Rieske
HKD3_k127_8569401_1	1382306.JNIM01000001_gene623	7.201e-78	276.0	COG2124@1|root,COG2124@2|Bacteria,2G7SX@200795|Chloroflexi	200795|Chloroflexi	C	PFAM Cytochrome P450	-	-	-	-	-	-	-	-	-	-	-	-	p450
HKD3_k127_8569401_0	1122604.JONR01000031_gene1279	9.78e-118	403.0	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1T5SE@1236|Gammaproteobacteria,1XDE6@135614|Xanthomonadales	135614|Xanthomonadales	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_19
HKD3_k127_8569401_4	497964.CfE428DRAFT_0753	4.684e-07	63.0	COG0515@1|root,COG0515@2|Bacteria,46UMT@74201|Verrucomicrobia	497964.CfE428DRAFT_0753|-	KLT	Serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_8600080_5	452637.Oter_3724	1.44e-40	153.0	COG0017@1|root,COG0017@2|Bacteria	2|Bacteria	J	Asparaginyl-tRNA synthetase	asnS	GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004816,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006421,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.1.1.22	ko:K01893	ko00970,map00970	M00359,M00360	R03648	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iSDY_1059.SDY_2327	tRNA-synt_2,tRNA_anti-codon
HKD3_k127_8600080_1	234267.Acid_4533	2.754e-190	602.0	COG1520@1|root,COG1520@2|Bacteria,3Y2H2@57723|Acidobacteria	57723|Acidobacteria	S	PQQ-like domain	-	-	1.1.2.6	ko:K05889	-	-	R03136	-	ko00000,ko01000	-	-	-	PQQ_3
HKD3_k127_8600080_7	479431.Namu_2249	3.765e-07	61.0	COG1073@1|root,COG1073@2|Bacteria,2IA0F@201174|Actinobacteria	201174|Actinobacteria	S	Hydrolases of the alpha beta superfamily	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Hydrolase_4
HKD3_k127_8600080_0	497964.CfE428DRAFT_1743	2.19e-300	932.0	COG1166@1|root,COG1166@2|Bacteria,46S4T@74201|Verrucomicrobia	74201|Verrucomicrobia	E	arginine decarboxylase	speA	-	4.1.1.19	ko:K01585	ko00330,ko01100,map00330,map01100	M00133	R00566	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N
HKD3_k127_8600080_4	497964.CfE428DRAFT_1741	9.918e-63	219.0	COG1259@1|root,COG1259@2|Bacteria,46SW6@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Bifunctional nuclease	-	-	-	ko:K08999	-	-	-	-	ko00000	-	-	-	DNase-RNase
HKD3_k127_8600080_2	278957.ABEA03000149_gene4043	1.555e-173	562.0	COG1080@1|root,COG1080@2|Bacteria,46TX4@74201|Verrucomicrobia,3K7JG@414999|Opitutae	414999|Opitutae	G	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)	-	-	2.7.3.9	ko:K08483	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	8.A.7	-	-	PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C
HKD3_k127_8600080_6	497964.CfE428DRAFT_4274	3.519e-35	136.0	COG1925@1|root,COG1925@2|Bacteria,46T6C@74201|Verrucomicrobia	74201|Verrucomicrobia	G	TIGRFAM phosphocarrier, HPr family	fruB	-	-	ko:K11189	-	-	-	-	ko00000,ko02000	4.A.2.1	-	-	PTS-HPr
HKD3_k127_8600080_3	497964.CfE428DRAFT_4273	1.033e-131	426.0	COG1493@1|root,COG1493@2|Bacteria,46S64@74201|Verrucomicrobia	74201|Verrucomicrobia	T	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr)	hprK	-	-	ko:K06023	-	-	-	-	ko00000,ko01000	-	-	-	Hpr_kinase_C,Hpr_kinase_N
HKD3_k127_8603944_10	566466.NOR53_420	1.217e-23	103.0	2EM9G@1|root,33EYK@2|Bacteria,1P8EM@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_8603944_6	1479239.JQMU01000001_gene1555	3.427e-44	164.0	COG3386@1|root,COG3386@2|Bacteria,1MVQM@1224|Proteobacteria,2U3TF@28211|Alphaproteobacteria,2K5IS@204457|Sphingomonadales	204457|Sphingomonadales	G	SMP-30/Gluconolaconase/LRE-like region	-	-	-	-	-	-	-	-	-	-	-	-	SGL
HKD3_k127_8603944_0	861299.J421_6202	8.691e-112	371.0	COG1064@1|root,COG1064@2|Bacteria,1ZSXS@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Zinc-binding dehydrogenase	-	-	1.1.1.1	ko:K13953	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
HKD3_k127_8603944_2	1122927.KB895414_gene5126	3.883e-110	367.0	COG0604@1|root,COG0604@2|Bacteria,1TQ0M@1239|Firmicutes,4HA8M@91061|Bacilli,26QXS@186822|Paenibacillaceae	91061|Bacilli	C	COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N_2
HKD3_k127_8603944_1	1267533.KB906737_gene2024	3.373e-111	370.0	COG0604@1|root,COG0604@2|Bacteria	2|Bacteria	C	NADPH:quinone reductase activity	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N_2
HKD3_k127_8603944_4	1267535.KB906767_gene1609	1.008e-93	314.0	arCOG07533@1|root,2ZF5I@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF4386)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4386
HKD3_k127_8603944_7	694427.Palpr_2302	3.113e-37	146.0	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	phnO	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006793,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0009987,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019634,GO:0019637,GO:0033051,GO:0044237,GO:0044424,GO:0044464,GO:0071704,GO:1901564	-	ko:K09994	ko00440,map00440	-	R11479	RC00096	ko00000,ko00001,ko01000	-	-	-	Acetyltransf_1,Acetyltransf_10
HKD3_k127_8603944_5	1198452.Jab_1c09970	2.071e-62	225.0	arCOG07533@1|root,2ZF5I@2|Bacteria,1RB8D@1224|Proteobacteria,2W871@28216|Betaproteobacteria,477Z9@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Domain of unknown function (DUF4386)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4386
HKD3_k127_8603944_8	1384054.N790_02950	9.987e-36	144.0	COG5485@1|root,COG5485@2|Bacteria,1RDG8@1224|Proteobacteria,1S4CM@1236|Gammaproteobacteria,1X71J@135614|Xanthomonadales	135614|Xanthomonadales	S	SnoaL-like polyketide cyclase	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL
HKD3_k127_8603944_3	1267533.KB906736_gene963	1.444e-95	324.0	2E7DT@1|root,32XVH@2|Bacteria,3Y712@57723|Acidobacteria,2JMBI@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	-
HKD3_k127_8603944_9	1267533.KB906736_gene962	4.646e-34	134.0	COG1131@1|root,COG1131@2|Bacteria,3Y7BR@57723|Acidobacteria,2JKD9@204432|Acidobacteriia	204432|Acidobacteriia	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD3_k127_8612273_34	240292.Ava_0532	1.821e-68	243.0	COG0395@1|root,COG0395@2|Bacteria,1G1XU@1117|Cyanobacteria,1HM9X@1161|Nostocales	1117|Cyanobacteria	G	PFAM Inward rectifier potassium channel	-	-	-	ko:K08715	-	-	-	-	ko00000,ko02000	1.A.2.2	-	-	IRK
HKD3_k127_8612273_35	404589.Anae109_3083	9.76e-68	236.0	COG3571@1|root,COG3571@2|Bacteria,1RD20@1224|Proteobacteria,42SGK@68525|delta/epsilon subdivisions,2WPDI@28221|Deltaproteobacteria,2YVW1@29|Myxococcales	28221|Deltaproteobacteria	S	Alpha/beta hydrolase family	-	-	-	ko:K07020	-	-	-	-	ko00000	-	-	-	Abhydrolase_4,Abhydrolase_5,DLH
HKD3_k127_8612273_58	136993.KB900626_gene693	9.148e-19	87.0	2C4SR@1|root,32TC7@2|Bacteria,1RCZG@1224|Proteobacteria,2U89H@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_8612273_27	1121939.L861_17460	3.272e-90	301.0	COG4430@1|root,COG4430@2|Bacteria,1RJGC@1224|Proteobacteria,1S853@1236|Gammaproteobacteria,1XK0S@135619|Oceanospirillales	135619|Oceanospirillales	S	Bacteriocin-protection, YdeI or OmpD-Associated	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801,OmdA
HKD3_k127_8612273_51	204669.Acid345_3466	1.051e-23	101.0	2DS5Y@1|root,33EPX@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_8612273_5	886293.Sinac_1862	1.129e-220	704.0	COG2234@1|root,COG2234@2|Bacteria,2IWTP@203682|Planctomycetes	203682|Planctomycetes	S	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
HKD3_k127_8612273_32	497964.CfE428DRAFT_1211	4.585e-75	271.0	COG0666@1|root,COG1376@1|root,COG0666@2|Bacteria,COG1376@2|Bacteria,46VM6@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Ankyrin repeats (3 copies)	-	-	-	-	-	-	-	-	-	-	-	-	Ank_2,YkuD
HKD3_k127_8612273_20	497964.CfE428DRAFT_3399	6.819e-118	396.0	COG0265@1|root,COG0265@2|Bacteria,46SHP@74201|Verrucomicrobia	74201|Verrucomicrobia	O	PFAM peptidase S1 and S6 chymotrypsin Hap	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
HKD3_k127_8612273_49	398512.JQKC01000036_gene4811	8.503e-27	117.0	COG4929@1|root,COG4929@2|Bacteria,1UPRT@1239|Firmicutes,24NGM@186801|Clostridia,3WPNH@541000|Ruminococcaceae	186801|Clostridia	S	GDYXXLXY protein	-	-	-	-	-	-	-	-	-	-	-	-	GDYXXLXY
HKD3_k127_8612273_33	1134912.AJTV01000061_gene3984	1.322e-71	261.0	COG4872@1|root,COG4872@2|Bacteria,1N3FM@1224|Proteobacteria	1224|Proteobacteria	S	Predicted membrane protein (DUF2157)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2157
HKD3_k127_8612273_55	525897.Dbac_2186	4.511e-21	94.0	2DRFV@1|root,33BJD@2|Bacteria,1NM2T@1224|Proteobacteria,42WGX@68525|delta/epsilon subdivisions,2WR8G@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_8612273_9	497964.CfE428DRAFT_6149	3.031e-166	542.0	COG2103@1|root,COG2971@1|root,COG2103@2|Bacteria,COG2971@2|Bacteria,46SJI@74201|Verrucomicrobia	74201|Verrucomicrobia	G	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate	-	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG,SIS_2
HKD3_k127_8612273_4	1396141.BATP01000005_gene6065	9.06e-227	723.0	COG0272@1|root,COG0272@2|Bacteria,46TMK@74201|Verrucomicrobia,2ITPR@203494|Verrucomicrobiae	203494|Verrucomicrobiae	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	-	-	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5
HKD3_k127_8612273_42	1037409.BJ6T_24570	6.706e-59	210.0	COG4566@1|root,COG4566@2|Bacteria,1N6WR@1224|Proteobacteria,2TRJB@28211|Alphaproteobacteria,3K5X9@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HKD3_k127_8612273_11	85643.Tmz1t_3869	3.935e-159	522.0	COG2202@1|root,COG4191@1|root,COG2202@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2VPV3@28216|Betaproteobacteria	28216|Betaproteobacteria	T	PAS fold	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3
HKD3_k127_8612273_29	497964.CfE428DRAFT_2398	1.846e-85	294.0	COG0265@1|root,COG0265@2|Bacteria,46T0K@74201|Verrucomicrobia	74201|Verrucomicrobia	O	Trypsin-like peptidase domain	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
HKD3_k127_8612273_25	497964.CfE428DRAFT_2400	3.823e-93	310.0	COG1595@1|root,COG1595@2|Bacteria,46SWN@74201|Verrucomicrobia	74201|Verrucomicrobia	K	ECF sigma factor	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD3_k127_8612273_43	452637.Oter_3489	3.51e-57	207.0	COG2738@1|root,COG2738@2|Bacteria,46THF@74201|Verrucomicrobia,3K7WD@414999|Opitutae	414999|Opitutae	S	Putative neutral zinc metallopeptidase	-	-	-	ko:K06973	-	-	-	-	ko00000	-	-	-	Zn_peptidase_2
HKD3_k127_8612273_17	497964.CfE428DRAFT_2401	3.756e-132	431.0	COG0006@1|root,COG0006@2|Bacteria,46SKG@74201|Verrucomicrobia	74201|Verrucomicrobia	E	Belongs to the peptidase M24B family	pepP	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
HKD3_k127_8612273_2	240016.ABIZ01000001_gene4121	0.0	1112.0	COG0842@1|root,COG1131@1|root,COG0842@2|Bacteria,COG1131@2|Bacteria,46TJ4@74201|Verrucomicrobia,2ITSH@203494|Verrucomicrobiae	203494|Verrucomicrobiae	V	ABC-2 type transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane,ABC_tran
HKD3_k127_8612273_7	1270193.JARP01000002_gene697	1.032e-194	625.0	COG4805@1|root,COG4805@2|Bacteria,4NFAK@976|Bacteroidetes,1HXAT@117743|Flavobacteriia,2NV5I@237|Flavobacterium	976|Bacteroidetes	S	Bacterial protein of unknown function (DUF885)	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
HKD3_k127_8612273_12	497964.CfE428DRAFT_2715	2.891e-154	498.0	COG0793@1|root,COG0793@2|Bacteria,46SM7@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Belongs to the peptidase S41A family	-	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_S41
HKD3_k127_8612273_21	497964.CfE428DRAFT_2716	2.171e-112	373.0	COG0533@1|root,COG0533@2|Bacteria,46SEH@74201|Verrucomicrobia	74201|Verrucomicrobia	O	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction	tsaD	-	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
HKD3_k127_8612273_19	497964.CfE428DRAFT_2718	2.88e-118	386.0	COG0142@1|root,COG0142@2|Bacteria,46S62@74201|Verrucomicrobia	74201|Verrucomicrobia	H	Belongs to the FPP GGPP synthase family	-	-	2.5.1.1,2.5.1.10,2.5.1.29	ko:K13789	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00366	R01658,R02003,R02061	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
HKD3_k127_8612273_63	1225184.ALXE01000001_gene2954	2.306e-08	66.0	COG0697@1|root,COG0697@2|Bacteria,1MWSU@1224|Proteobacteria,1RSF8@1236|Gammaproteobacteria,3VZ0U@53335|Pantoea	1236|Gammaproteobacteria	EG	Transporter	yyaM	-	-	-	-	-	-	-	-	-	-	-	EamA
HKD3_k127_8612273_56	63737.Npun_R4596	1.818e-20	103.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,1FZWQ@1117|Cyanobacteria,1HKUX@1161|Nostocales	1117|Cyanobacteria	KLT	Serine Threonine protein kinase	-	-	2.7.11.1	ko:K08884	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_1,TPR_11,TPR_16,TPR_2,TPR_6,TPR_8
HKD3_k127_8612273_6	240016.ABIZ01000001_gene4940	1.538e-218	681.0	COG0050@1|root,COG0050@2|Bacteria,46SFG@74201|Verrucomicrobia,2ITQE@203494|Verrucomicrobiae	203494|Verrucomicrobiae	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
HKD3_k127_8612273_54	497964.CfE428DRAFT_5633	2.762e-21	96.0	COG0690@1|root,COG0690@2|Bacteria,46T9W@74201|Verrucomicrobia	74201|Verrucomicrobia	U	SecE/Sec61-gamma subunits of protein translocation complex	secE	-	-	ko:K03073	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecE
HKD3_k127_8612273_28	1396141.BATP01000023_gene539	1.462e-85	286.0	COG0250@1|root,COG0250@2|Bacteria,46SR6@74201|Verrucomicrobia,2IU6S@203494|Verrucomicrobiae	203494|Verrucomicrobiae	K	In Spt5p, this domain may confer affinity for Spt4p. It possesses a RNP-like fold.	nusG	-	-	ko:K02601	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KOW,NusG
HKD3_k127_8612273_37	497964.CfE428DRAFT_5631	1.476e-67	231.0	COG0080@1|root,COG0080@2|Bacteria,46SPZ@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors	rplK	-	-	ko:K02867	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L11,Ribosomal_L11_N
HKD3_k127_8612273_10	639030.JHVA01000001_gene188	6.616e-164	539.0	COG4805@1|root,COG4805@2|Bacteria,3Y71M@57723|Acidobacteria,2JKC6@204432|Acidobacteriia	204432|Acidobacteriia	S	Bacterial protein of unknown function (DUF885)	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
HKD3_k127_8612273_65	269797.Mbar_A1627	0.0003609	52.0	COG3291@1|root,arCOG03383@1|root,arCOG02510@2157|Archaea,arCOG03383@2157|Archaea	2157|Archaea	E	COG1506 Dipeptidyl aminopeptidases acylaminoacyl-peptidases	-	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	CBM_6,NosD,PD40,PKD
HKD3_k127_8612273_18	1096930.L284_12450	3.532e-125	423.0	COG2936@1|root,COG2936@2|Bacteria,1R2BJ@1224|Proteobacteria,2TZGD@28211|Alphaproteobacteria,2K5IN@204457|Sphingomonadales	204457|Sphingomonadales	S	X-Pro dipeptidyl-peptidase (S15 family)	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S15
HKD3_k127_8612273_38	945713.IALB_2399	6.379e-66	250.0	COG1807@1|root,COG1807@2|Bacteria	2|Bacteria	M	4-amino-4-deoxy-L-arabinose transferase activity	-	-	-	ko:K13687	-	-	-	-	ko00000,ko01000,ko01003	-	GT89	-	DUF2723,PMT_2
HKD3_k127_8612273_22	497964.CfE428DRAFT_5605	2.831e-108	355.0	COG0081@1|root,COG0081@2|Bacteria,46S7K@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release	rplA	-	-	ko:K02863	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L1
HKD3_k127_8612273_47	240016.ABIZ01000001_gene4935	7.473e-43	162.0	COG0244@1|root,COG0244@2|Bacteria,46T4Q@74201|Verrucomicrobia,2IUF1@203494|Verrucomicrobiae	203494|Verrucomicrobiae	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rplJ	-	-	ko:K02864	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L10
HKD3_k127_8612273_46	497964.CfE428DRAFT_5603	2.4e-45	168.0	COG0222@1|root,COG0222@2|Bacteria,46SWC@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation	rplL	-	-	ko:K02935	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L12,Ribosomal_L12_N
HKD3_k127_8612273_1	497964.CfE428DRAFT_5596	0.0	2186.0	COG0085@1|root,COG0085@2|Bacteria,46S8Q@74201|Verrucomicrobia	74201|Verrucomicrobia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	-	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
HKD3_k127_8612273_0	497964.CfE428DRAFT_5595	0.0	2258.0	COG0086@1|root,COG0086@2|Bacteria,46S79@74201|Verrucomicrobia	74201|Verrucomicrobia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	-	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
HKD3_k127_8612273_44	497964.CfE428DRAFT_3450	1.943e-55	200.0	COG2096@1|root,COG2096@2|Bacteria,46T1G@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Cobalamin adenosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Cob_adeno_trans
HKD3_k127_8612273_39	1335760.ASTG01000008_gene972	4.424e-64	231.0	COG3637@1|root,COG3637@2|Bacteria,1PW82@1224|Proteobacteria,2U8GW@28211|Alphaproteobacteria,2K6DC@204457|Sphingomonadales	204457|Sphingomonadales	M	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_8612273_40	497964.CfE428DRAFT_2687	1.414e-61	216.0	COG4659@1|root,COG4659@2|Bacteria	2|Bacteria	C	FMN binding	rnfG	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03612	-	-	-	-	ko00000	-	-	-	FMN_bind
HKD3_k127_8612273_36	1122604.JONR01000010_gene3879	1.198e-67	240.0	COG1477@1|root,COG1477@2|Bacteria,1MW6K@1224|Proteobacteria,1RNMZ@1236|Gammaproteobacteria,1X42D@135614|Xanthomonadales	135614|Xanthomonadales	H	Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein	-	-	2.7.1.180	ko:K03734	-	-	-	-	ko00000,ko01000	-	-	-	ApbE
HKD3_k127_8612273_52	402626.Rpic_1885	1.434e-23	111.0	2E4Z6@1|root,32ZSW@2|Bacteria,1N6U2@1224|Proteobacteria,2VW9R@28216|Betaproteobacteria,1K8VF@119060|Burkholderiaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_8612273_23	497964.CfE428DRAFT_2906	1.306e-107	353.0	COG0052@1|root,COG0052@2|Bacteria,46SNG@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Belongs to the universal ribosomal protein uS2 family	rpsB	-	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
HKD3_k127_8612273_31	240016.ABIZ01000001_gene737	1.049e-76	262.0	COG0264@1|root,COG0264@2|Bacteria,46SUK@74201|Verrucomicrobia,2IU52@203494|Verrucomicrobiae	203494|Verrucomicrobiae	J	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome	tsf	-	-	ko:K02357	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EF_TS
HKD3_k127_8612273_8	497964.CfE428DRAFT_4309	1.77e-179	581.0	COG1793@1|root,COG1793@2|Bacteria,46S9X@74201|Verrucomicrobia	74201|Verrucomicrobia	L	DNA polymerase Ligase (LigD)	-	-	6.5.1.1	ko:K01971	ko03450,map03450	-	R00381	RC00005	ko00000,ko00001,ko01000,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,LigD_N
HKD3_k127_8612273_14	667014.Thein_1524	1.829e-151	485.0	COG0438@1|root,COG0438@2|Bacteria,2GHNP@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
HKD3_k127_8612273_3	330214.NIDE3191	1.067e-282	885.0	COG3408@1|root,COG3408@2|Bacteria,3J0Z8@40117|Nitrospirae	40117|Nitrospirae	G	Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain	-	-	-	-	-	-	-	-	-	-	-	-	GDE_C,GDE_N_bis
HKD3_k127_8612273_53	497964.CfE428DRAFT_0821	5.397e-23	101.0	COG1828@1|root,COG1828@2|Bacteria,46WNB@74201|Verrucomicrobia	74201|Verrucomicrobia	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purS	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	PurS
HKD3_k127_8612273_61	305900.GV64_02625	4.444e-11	65.0	COG0401@1|root,COG0401@2|Bacteria,1QG3Q@1224|Proteobacteria,1SIVT@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Proteolipid membrane potential modulator	-	-	-	-	-	-	-	-	-	-	-	-	Pmp3
HKD3_k127_8612273_26	497964.CfE428DRAFT_0819	2.6e-91	306.0	COG0047@1|root,COG0047@2|Bacteria,46T5R@74201|Verrucomicrobia	74201|Verrucomicrobia	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purQ	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase_5
HKD3_k127_8612273_13	497964.CfE428DRAFT_2495	1.763e-151	488.0	COG0162@1|root,COG0162@2|Bacteria,46S76@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	-	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	S4,tRNA-synt_1b
HKD3_k127_8612273_50	926554.KI912633_gene3824	1.007e-26	112.0	COG3360@1|root,COG3360@2|Bacteria,1WKKK@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Dodecin	-	-	-	ko:K09165	-	-	-	-	ko00000	-	-	-	Dodecin
HKD3_k127_8612273_66	1396141.BATP01000007_gene5705	0.0008714	46.0	COG1633@1|root,COG1633@2|Bacteria	2|Bacteria	S	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)	-	-	1.16.3.1	ko:K03594	ko00860,map00860	-	R00078	RC02758	ko00000,ko00001,ko01000	-	-	-	DUF2383
HKD3_k127_8612273_24	497964.CfE428DRAFT_0335	5.793e-98	331.0	COG1092@1|root,COG1092@2|Bacteria,46SYW@74201|Verrucomicrobia	74201|Verrucomicrobia	J	S-adenosylmethionine-dependent methyltransferase	-	-	2.1.1.191	ko:K06969	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_SAM
HKD3_k127_8612273_30	497964.CfE428DRAFT_2912	4.837e-80	281.0	COG0083@1|root,COG0083@2|Bacteria,46STT@74201|Verrucomicrobia	74201|Verrucomicrobia	E	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate	thrB	-	2.7.1.39	ko:K00872	ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230	M00018	R01771	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
HKD3_k127_8612273_15	497964.CfE428DRAFT_2911	3.163e-145	475.0	COG1663@1|root,COG1663@2|Bacteria,46SBI@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)	lpxK	-	2.7.1.130	ko:K00912	ko00540,ko01100,map00540,map01100	M00060	R04657	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	LpxK
HKD3_k127_8612273_16	204669.Acid345_2863	4.086e-138	447.0	COG3285@1|root,COG3285@2|Bacteria,3Y637@57723|Acidobacteria,2JM9H@204432|Acidobacteriia	204432|Acidobacteriia	L	dna ligase	-	-	6.5.1.1	ko:K01971	ko03450,map03450	-	R00381	RC00005	ko00000,ko00001,ko01000,ko03400	-	-	-	-
HKD3_k127_8612273_57	1128421.JAGA01000002_gene1863	1.944e-19	90.0	2EFVT@1|root,339N0@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Imp-YgjV
HKD3_k127_8612273_45	1396418.BATQ01000133_gene4088	1.46e-46	177.0	COG3837@1|root,COG3837@2|Bacteria,46T0V@74201|Verrucomicrobia,2IU8V@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	AraC-like ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HKD3_k127_8612273_41	497964.CfE428DRAFT_1049	4.329e-59	208.0	COG3837@1|root,COG3837@2|Bacteria,46T0V@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HKD3_k127_8612273_48	1267533.KB906740_gene377	3.203e-27	111.0	COG0662@1|root,COG0662@2|Bacteria	2|Bacteria	G	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HKD3_k127_8627068_4	1120797.KB908262_gene2997	4.937e-122	399.0	COG3386@1|root,COG3386@2|Bacteria	2|Bacteria	G	gluconolactonase activity	-	-	3.1.1.17	ko:K01053	ko00030,ko00053,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,map00030,map00053,map00930,map01100,map01110,map01120,map01130,map01200,map01220	M00129	R01519,R02933,R03751	RC00537,RC00983	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Esterase,SGL
HKD3_k127_8627068_12	419947.MRA_2629A	1.018e-08	59.0	2DGZX@1|root,2ZXWY@2|Bacteria,2HDW7@201174|Actinobacteria	201174|Actinobacteria	-	-	-	GO:0008150,GO:0040008,GO:0045927,GO:0048518,GO:0050789,GO:0065007	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_8627068_13	1089550.ATTH01000001_gene1311	1.05e-05	53.0	COG1848@1|root,COG1848@2|Bacteria	2|Bacteria	G	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	ko:K07064	-	-	-	-	ko00000	-	-	-	PIN
HKD3_k127_8627068_6	1122604.JONR01000004_gene853	1.763e-99	350.0	COG5616@1|root,COG5616@2|Bacteria,1NSKC@1224|Proteobacteria,1T49A@1236|Gammaproteobacteria,1XDC3@135614|Xanthomonadales	135614|Xanthomonadales	S	cAMP biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_8627068_2	1122603.ATVI01000005_gene3499	1.118e-129	435.0	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1S1MS@1236|Gammaproteobacteria,1X9I0@135614|Xanthomonadales	135614|Xanthomonadales	T	Adenylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	TPR_8
HKD3_k127_8627068_3	1122603.ATVI01000005_gene3498	3.313e-127	432.0	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1SZ6C@1236|Gammaproteobacteria,1XCCV@135614|Xanthomonadales	1236|Gammaproteobacteria	T	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,TPR_19,TPR_2,TPR_8
HKD3_k127_8627068_1	64471.sync_2679	1.147e-169	548.0	COG0154@1|root,COG0154@2|Bacteria,1G0HS@1117|Cyanobacteria,1GZCX@1129|Synechococcus	1117|Cyanobacteria	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	-	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
HKD3_k127_8627068_0	1122603.ATVI01000005_gene3499	3.515e-194	621.0	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1S1MS@1236|Gammaproteobacteria,1X9I0@135614|Xanthomonadales	135614|Xanthomonadales	T	Adenylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	TPR_8
HKD3_k127_8627068_11	1265503.KB905166_gene652	2.961e-20	101.0	COG5616@1|root,COG5616@2|Bacteria,1NSKC@1224|Proteobacteria,1S0KQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	cAMP biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_8627068_9	1267534.KB906754_gene3444	4.098e-45	175.0	COG4319@1|root,COG4319@2|Bacteria,3Y5FP@57723|Acidobacteria,2JN7M@204432|Acidobacteriia	204432|Acidobacteriia	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440
HKD3_k127_8627068_10	1123073.KB899243_gene504	7.62e-35	140.0	2AEZN@1|root,314XR@2|Bacteria,1NSHG@1224|Proteobacteria,1SMR4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_8627068_7	1223521.BBJX01000014_gene314	3e-74	260.0	COG1893@1|root,COG1893@2|Bacteria,1P0AW@1224|Proteobacteria,2VKYM@28216|Betaproteobacteria,4AA9N@80864|Comamonadaceae	28216|Betaproteobacteria	H	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid	apbA	-	1.1.1.169	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R02472	RC00726	ko00000,ko00001,ko00002,ko01000	-	-	-	ApbA,ApbA_C
HKD3_k127_8627068_8	1267533.KB906736_gene961	4.199e-51	184.0	COG1725@1|root,COG1725@2|Bacteria,3Y5VN@57723|Acidobacteria,2JK5T@204432|Acidobacteriia	2|Bacteria	K	helix_turn_helix gluconate operon transcriptional repressor	ytrA	-	-	ko:K07979	-	-	-	-	ko00000,ko03000	-	-	-	GntR
HKD3_k127_8627068_5	1267533.KB906736_gene962	4.098e-110	359.0	COG1131@1|root,COG1131@2|Bacteria,3Y7BR@57723|Acidobacteria,2JKD9@204432|Acidobacteriia	204432|Acidobacteriia	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD3_k127_8652202_13	497964.CfE428DRAFT_1722	2.638e-75	259.0	COG1028@1|root,COG1028@2|Bacteria,46V2S@74201|Verrucomicrobia	74201|Verrucomicrobia	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HKD3_k127_8652202_4	1454004.AW11_00555	7.123e-117	389.0	COG1322@1|root,COG1322@2|Bacteria,1MWHV@1224|Proteobacteria,2VJVZ@28216|Betaproteobacteria,1KPQ8@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	S	DNA recombination protein RmuC	rmuC	-	-	ko:K09760	-	-	-	-	ko00000	-	-	-	RmuC
HKD3_k127_8652202_8	204669.Acid345_1478	3.82e-102	341.0	COG0345@1|root,COG0345@2|Bacteria,3Y41B@57723|Acidobacteria,2JITZ@204432|Acidobacteriia	204432|Acidobacteriia	E	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline	proC	-	1.5.1.2	ko:K00286	ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230	M00015	R01248,R01251,R03291,R03293	RC00054,RC00083	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_oxidored,P5CR_dimer
HKD3_k127_8652202_9	338963.Pcar_0454	8.445e-96	337.0	COG4206@1|root,COG4206@2|Bacteria,1MW63@1224|Proteobacteria,43BRF@68525|delta/epsilon subdivisions,2WKAH@28221|Deltaproteobacteria,43TV7@69541|Desulfuromonadales	28221|Deltaproteobacteria	P	TonB dependent receptor	btuB	-	-	ko:K02014,ko:K16092	-	-	-	-	ko00000,ko02000	1.B.14,1.B.14.3	-	-	Plug,TonB_dep_Rec
HKD3_k127_8652202_6	671143.DAMO_2943	7.601e-104	346.0	COG0451@1|root,COG0451@2|Bacteria,2NPSM@2323|unclassified Bacteria	2|Bacteria	GM	Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose	hldD	GO:0000166,GO:0000271,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008712,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016853,GO:0016854,GO:0016857,GO:0033692,GO:0034637,GO:0034645,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046401,GO:0048037,GO:0050661,GO:0050662,GO:0070401,GO:0071704,GO:0097159,GO:1901135,GO:1901137,GO:1901265,GO:1901363,GO:1901576,GO:1903509	5.1.3.20	ko:K03274	ko00540,ko01100,map00540,map01100	M00064	R05176	RC01291	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	iPC815.YPO0058,iYL1228.KPN_03963	Epimerase
HKD3_k127_8652202_17	497964.CfE428DRAFT_3622	1.218e-46	172.0	COG1765@1|root,COG1765@2|Bacteria,46T1Y@74201|Verrucomicrobia	74201|Verrucomicrobia	O	PFAM OsmC family protein	-	-	-	-	-	-	-	-	-	-	-	-	OsmC
HKD3_k127_8652202_3	28042.GU90_10355	9.444e-135	449.0	COG0531@1|root,COG0531@2|Bacteria,2GJ75@201174|Actinobacteria,4DXT1@85010|Pseudonocardiales	201174|Actinobacteria	E	amino acid	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
HKD3_k127_8652202_22	388413.ALPR1_16109	1.589e-29	132.0	COG1566@1|root,COG1566@2|Bacteria,4NH7M@976|Bacteroidetes,47R1H@768503|Cytophagia	976|Bacteroidetes	V	Protein of unknown function (DUF3667)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3667
HKD3_k127_8652202_7	497964.CfE428DRAFT_3140	2.974e-102	342.0	COG0823@1|root,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	-	ko:K03641,ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001,ko02000	2.C.1.2	-	-	HYR,PD40
HKD3_k127_8652202_12	497964.CfE428DRAFT_3141	1.143e-81	286.0	COG4946@1|root,COG4946@2|Bacteria	2|Bacteria	M	serine-type peptidase activity	tolB	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	Amidohydro_1,PD40,PG_binding_1,Pkinase,TolB_N,WD40
HKD3_k127_8652202_0	497964.CfE428DRAFT_3135	0.0	1045.0	COG0013@1|root,COG0013@2|Bacteria,46SAY@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
HKD3_k127_8652202_1	497964.CfE428DRAFT_0030	5.344e-170	539.0	COG0468@1|root,COG0468@2|Bacteria,46SIZ@74201|Verrucomicrobia	74201|Verrucomicrobia	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage	recA	-	-	ko:K03553	ko03440,map03440	M00729	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	RecA
HKD3_k127_8652202_21	497964.CfE428DRAFT_3684	4.64e-35	137.0	COG0071@1|root,COG0071@2|Bacteria,46WRX@74201|Verrucomicrobia	74201|Verrucomicrobia	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	-	-	-	-	-	-	-	-	-	HSP20
HKD3_k127_8652202_18	497964.CfE428DRAFT_3685	1.249e-44	169.0	COG0071@1|root,COG0071@2|Bacteria,46T3G@74201|Verrucomicrobia	74201|Verrucomicrobia	O	Belongs to the small heat shock protein (HSP20) family	ibpA	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
HKD3_k127_8652202_26	886293.Sinac_3961	0.0005435	52.0	COG2013@1|root,COG2013@2|Bacteria	2|Bacteria	S	Mitochondrial biogenesis AIM24	-	-	-	-	-	-	-	-	-	-	-	-	AIM24
HKD3_k127_8652202_5	497964.CfE428DRAFT_4746	7.806e-111	365.0	COG0258@1|root,COG0258@2|Bacteria,46SWB@74201|Verrucomicrobia	74201|Verrucomicrobia	L	5'-3' exonuclease	exo	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N
HKD3_k127_8652202_10	497964.CfE428DRAFT_4998	2.219e-91	312.0	COG0157@1|root,COG0157@2|Bacteria,46SPY@74201|Verrucomicrobia	74201|Verrucomicrobia	H	Belongs to the NadC ModD family	nadC	-	2.4.2.19	ko:K00767	ko00760,ko01100,map00760,map01100	M00115	R03348	RC02877	ko00000,ko00001,ko00002,ko01000	-	-	-	QRPTase_C,QRPTase_N
HKD3_k127_8652202_19	497964.CfE428DRAFT_4997	2.158e-44	169.0	COG0340@1|root,COG0340@2|Bacteria,46SX6@74201|Verrucomicrobia	74201|Verrucomicrobia	H	Biotin/lipoate A/B protein ligase family	birA	-	6.3.4.15	ko:K03524	ko00780,ko01100,map00780,map01100	-	R01074,R05145	RC00043,RC00070,RC00096,RC02896	ko00000,ko00001,ko01000,ko03000	-	-	-	BPL_C,BPL_LplA_LipB,HTH_11
HKD3_k127_8652202_2	497964.CfE428DRAFT_2106	5.103e-166	532.0	COG1522@1|root,COG1522@2|Bacteria,46SDK@74201|Verrucomicrobia	74201|Verrucomicrobia	K	sequence-specific DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_8652202_14	335283.Neut_0487	1.026e-66	236.0	COG1272@1|root,COG1272@2|Bacteria,1PGRH@1224|Proteobacteria,2VJR4@28216|Betaproteobacteria,372CA@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Haemolysin-III related	-	-	-	ko:K11068	-	-	-	-	ko00000,ko02042	-	-	-	HlyIII
HKD3_k127_8652202_15	497964.CfE428DRAFT_1788	1.363e-66	236.0	COG1011@1|root,COG1011@2|Bacteria,46T57@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Haloacid dehalogenase-like hydrolase	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2
HKD3_k127_8652202_24	546262.NEICINOT_03254	1.453e-22	105.0	2FACE@1|root,342KV@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_8652202_23	561229.Dd1591_2517	1.483e-24	108.0	COG3547@1|root,COG3547@2|Bacteria,1MXKJ@1224|Proteobacteria,1RSCP@1236|Gammaproteobacteria,2JERQ@204037|Dickeya	1236|Gammaproteobacteria	L	PFAM transposase IS116 IS110 IS902 family protein	Z012_08285	-	-	ko:K07486	-	-	-	-	ko00000	-	-	-	DEDD_Tnp_IS110,Transposase_20
HKD3_k127_8652202_11	1267535.KB906767_gene1119	2.09e-88	299.0	293RY@1|root,2ZR7G@2|Bacteria,3Y953@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_8663_3	497964.CfE428DRAFT_0734	2.54e-56	203.0	COG0817@1|root,COG0817@2|Bacteria,46T3Y@74201|Verrucomicrobia	74201|Verrucomicrobia	L	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group	ruvC	-	3.1.22.4	ko:K01159	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvC
HKD3_k127_8663_2	497964.CfE428DRAFT_4414	3.216e-75	263.0	COG0321@1|root,COG0321@2|Bacteria,46T11@74201|Verrucomicrobia	74201|Verrucomicrobia	H	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate	lipB	-	2.3.1.181	ko:K03801	ko00785,ko01100,map00785,map01100	-	R07766,R07769	RC00039,RC00992,RC02867	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB
HKD3_k127_8663_1	1156937.MFUM_730004	4.878e-95	318.0	COG0491@1|root,COG0491@2|Bacteria,46S7X@74201|Verrucomicrobia,37GB4@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HKD3_k127_8663_4	879212.DespoDRAFT_00979	2.457e-32	129.0	2CCSR@1|root,32K43@2|Bacteria,1QJ8W@1224|Proteobacteria,43A9D@68525|delta/epsilon subdivisions,2X0VC@28221|Deltaproteobacteria,2MPDZ@213118|Desulfobacterales	28221|Deltaproteobacteria	S	23S rRNA-intervening sequence protein	-	-	-	-	-	-	-	-	-	-	-	-	23S_rRNA_IVP
HKD3_k127_8663_0	497964.CfE428DRAFT_2386	8.844e-121	395.0	COG2084@1|root,COG2084@2|Bacteria,46S95@74201|Verrucomicrobia	74201|Verrucomicrobia	I	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_11,NAD_binding_2
HKD3_k127_8673094_6	164757.Mjls_4245	5.297e-09	62.0	COG0730@1|root,COG0730@2|Bacteria,2I5VT@201174|Actinobacteria,234VT@1762|Mycobacteriaceae	201174|Actinobacteria	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
HKD3_k127_8673094_3	1437425.CSEC_1842	1.319e-82	284.0	COG0121@1|root,COG0121@2|Bacteria,2JG9A@204428|Chlamydiae	204428|Chlamydiae	S	Glutamine amidotransferases class-II	-	-	-	-	-	-	-	-	-	-	-	-	GATase_4
HKD3_k127_8673094_8	936136.ARRT01000007_gene1152	4.144e-07	53.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,2TR80@28211|Alphaproteobacteria,4B7RZ@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	Cation transport ATPase	actP	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,Hydrolase,YHS
HKD3_k127_8673094_4	1210884.HG799464_gene10983	1.591e-58	214.0	COG1611@1|root,COG1611@2|Bacteria	2|Bacteria	S	cytokinin biosynthetic process	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	YHS
HKD3_k127_8673094_9	478741.JAFS01000002_gene163	2.182e-06	57.0	2BFVZ@1|root,329RE@2|Bacteria,46ZG6@74201|Verrucomicrobia,37H0W@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_8673094_7	478741.JAFS01000002_gene163	2.405e-07	54.0	2BFVZ@1|root,329RE@2|Bacteria,46ZG6@74201|Verrucomicrobia,37H0W@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_8673094_1	331113.SNE_B24410	1.123e-232	732.0	COG0058@1|root,COG0058@2|Bacteria,2JFEH@204428|Chlamydiae	204428|Chlamydiae	G	Carbohydrate phosphorylase	glgP	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	Phosphorylase
HKD3_k127_8673094_0	452637.Oter_4432	0.0	1690.0	COG3696@1|root,COG3696@2|Bacteria,46SJ1@74201|Verrucomicrobia,3K7EV@414999|Opitutae	414999|Opitutae	P	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K07787	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4	-	-	ACR_tran
HKD3_k127_8673094_2	452637.Oter_4431	8.535e-145	475.0	COG0845@1|root,COG0845@2|Bacteria,46SVD@74201|Verrucomicrobia,3K8NI@414999|Opitutae	414999|Opitutae	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K07798	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4,8.A.1	-	-	DUF3347,HlyD_D23
HKD3_k127_8673094_5	497964.CfE428DRAFT_2704	3.787e-50	187.0	COG1538@1|root,COG1538@2|Bacteria	2|Bacteria	MU	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	OEP
HKD3_k127_8677663_2	452637.Oter_4406	2.404e-39	155.0	COG0755@1|root,COG0755@2|Bacteria,46SIH@74201|Verrucomicrobia,3K7UF@414999|Opitutae	414999|Opitutae	O	PFAM cytochrome c assembly protein	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C_asm
HKD3_k127_8677663_1	452637.Oter_2587	1.168e-114	381.0	COG1333@1|root,COG1333@2|Bacteria,46SUY@74201|Verrucomicrobia,3K75U@414999|Opitutae	414999|Opitutae	O	ResB-like family	-	-	-	-	-	-	-	-	-	-	-	-	ResB
HKD3_k127_8677663_3	452637.Oter_2586	5.07e-36	151.0	2E533@1|root,32ZW9@2|Bacteria,46SZX@74201|Verrucomicrobia,3K856@414999|Opitutae	414999|Opitutae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_8677663_0	452637.Oter_2584	1.288e-140	462.0	COG3005@1|root,COG3005@2|Bacteria	2|Bacteria	C	denitrification pathway	-	GO:0003674,GO:0003824,GO:0005575,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0022900,GO:0031224,GO:0044237,GO:0044425,GO:0045333,GO:0055114	-	ko:K15876	ko00910,ko01120,map00910,map01120	M00530	R05712	RC00176	ko00000,ko00001,ko00002	-	-	-	Cytochrom_NNT,Cytochrom_c3_2
HKD3_k127_8677663_5	452637.Oter_2585	6.298e-16	81.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
HKD3_k127_8677663_6	452637.Oter_2585	4.097e-15	80.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
HKD3_k127_8698212_1	269799.Gmet_2703	2.692e-56	204.0	COG0581@1|root,COG0581@2|Bacteria,1MUWB@1224|Proteobacteria,42MWK@68525|delta/epsilon subdivisions,2WMUA@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	TIGRFAM phosphate ABC transporter	pstA	-	-	ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
HKD3_k127_8698212_0	478741.JAFS01000002_gene901	5.425e-104	349.0	COG0573@1|root,COG0573@2|Bacteria,46T46@74201|Verrucomicrobia,37GBC@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	P	probably responsible for the translocation of the substrate across the membrane	pstC	-	-	ko:K02037	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
HKD3_k127_8698212_2	443144.GM21_1874	3.201e-52	188.0	COG0394@1|root,COG0394@2|Bacteria,1MWYQ@1224|Proteobacteria,42SQK@68525|delta/epsilon subdivisions,2WPK1@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	PFAM Protein-tyrosine phosphatase, low molecular weight	-	-	1.20.4.1	ko:K03741	-	-	-	-	ko00000,ko01000	-	-	-	LMWPc
HKD3_k127_8698212_3	404380.Gbem_1852	6.681e-25	105.0	COG0226@1|root,COG0226@2|Bacteria,1MUAZ@1224|Proteobacteria,42NM3@68525|delta/epsilon subdivisions,2WMH9@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	Part of the ABC transporter complex PstSACB involved in phosphate import	pstS	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
HKD3_k127_8700604_19	1463934.JOCF01000015_gene514	2.242e-26	122.0	28JBD@1|root,2Z964@2|Bacteria,2H0C3@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_8700604_1	269799.Gmet_1194	1.033e-158	544.0	2DB7D@1|root,2Z7KR@2|Bacteria,1Q0FB@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_8700604_27	746697.Aeqsu_0043	5.549e-05	53.0	COG5661@1|root,COG5661@2|Bacteria,4NW11@976|Bacteroidetes,1I32R@117743|Flavobacteriia	976|Bacteroidetes	O	secreted Zn-dependent protease	-	-	-	-	-	-	-	-	-	-	-	-	DUF922
HKD3_k127_8700604_10	82654.Pse7367_0121	1.234e-50	196.0	COG2931@1|root,COG2931@2|Bacteria,1G67W@1117|Cyanobacteria,1HASU@1150|Oscillatoriales	1117|Cyanobacteria	Q	Haemolysin-type calcium-binding repeat	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,HemolysinCabind
HKD3_k127_8700604_17	748247.AZKH_1177	6.073e-30	128.0	2D2IW@1|root,32TCX@2|Bacteria,1N4MH@1224|Proteobacteria,2W1UY@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Protein of unknown function (DUF1353)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1353
HKD3_k127_8700604_9	572547.Amico_1593	2.128e-63	222.0	COG2110@1|root,COG2110@2|Bacteria,3TBCJ@508458|Synergistetes	508458|Synergistetes	S	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Macro
HKD3_k127_8700604_7	1173026.Glo7428_0383	2.153e-76	264.0	COG0259@1|root,COG0259@2|Bacteria,1G0HC@1117|Cyanobacteria	1117|Cyanobacteria	H	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP)	pdxH	-	1.4.3.5	ko:K00275	ko00750,ko01100,ko01120,map00750,map01100,map01120	M00124	R00277,R00278,R01710,R01711	RC00048,RC00116	ko00000,ko00001,ko00002,ko01000	-	-	iJN678.pdxH	PNP_phzG_C,Putative_PNPOx
HKD3_k127_8700604_2	1396418.BATQ01000091_gene5776	2.108e-148	479.0	COG0079@1|root,COG0079@2|Bacteria,46SFP@74201|Verrucomicrobia,2ITIN@203494|Verrucomicrobiae	203494|Verrucomicrobiae	E	Aminotransferase class I and II	-	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
HKD3_k127_8700604_3	497964.CfE428DRAFT_4709	6.217e-143	468.0	COG0486@1|root,COG0486@2|Bacteria,46SIQ@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34	mnmE	-	-	ko:K03650	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko01000,ko03016	-	-	-	MMR_HSR1,MnmE_helical,TrmE_N
HKD3_k127_8700604_5	497964.CfE428DRAFT_4708	1.56e-113	376.0	COG0167@1|root,COG0167@2|Bacteria,46S5W@74201|Verrucomicrobia	74201|Verrucomicrobia	F	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor	pyrD	-	1.3.5.2	ko:K00254	ko00240,ko01100,map00240,map01100	M00051	R01868	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
HKD3_k127_8700604_16	113395.AXAI01000002_gene5313	9.524e-37	148.0	2EFWC@1|root,339NM@2|Bacteria,1NG7T@1224|Proteobacteria,2UY62@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_8700604_25	278957.ABEA03000097_gene797	1.291e-08	61.0	2A1I4@1|root,30PRV@2|Bacteria,46XXK@74201|Verrucomicrobia,3K8JP@414999|Opitutae	414999|Opitutae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_8700604_13	497964.CfE428DRAFT_1388	1.251e-46	174.0	COG1595@1|root,COG1595@2|Bacteria,46STJ@74201|Verrucomicrobia	74201|Verrucomicrobia	K	Sigma-70 region 2	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD3_k127_8700604_28	1382359.JIAL01000001_gene810	0.0003282	49.0	2EGII@1|root,33AAP@2|Bacteria,3Y5ST@57723|Acidobacteria,2JK57@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_8700604_0	1122134.KB893650_gene1319	9.786e-239	752.0	COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,1RMIT@1236|Gammaproteobacteria,1XJ36@135619|Oceanospirillales	135619|Oceanospirillales	E	Gamma-glutamyltranspeptidase	-	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
HKD3_k127_8700604_15	65393.PCC7424_2487	1.122e-38	150.0	2AFHA@1|root,315HT@2|Bacteria,1G5WD@1117|Cyanobacteria,3KIDV@43988|Cyanothece	1117|Cyanobacteria	J	23S rRNA-intervening sequence protein	-	-	-	-	-	-	-	-	-	-	-	-	23S_rRNA_IVP
HKD3_k127_8700604_11	497964.CfE428DRAFT_4518	4.817e-49	180.0	COG0791@1|root,COG0791@2|Bacteria,46VUJ@74201|Verrucomicrobia	74201|Verrucomicrobia	M	NLP P60 protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_8700604_4	756272.Plabr_3129	8.254e-115	391.0	COG1680@1|root,COG1680@2|Bacteria,2IWSU@203682|Planctomycetes	203682|Planctomycetes	MV	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase,DUF3471
HKD3_k127_8700604_8	234267.Acid_0055	6.841e-67	236.0	2AY4N@1|root,31Q6J@2|Bacteria,3Y7H6@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_8700604_22	265072.Mfla_0410	1.249e-17	85.0	COG4974@1|root,COG4974@2|Bacteria,1MVAN@1224|Proteobacteria,2VHUC@28216|Betaproteobacteria,2KKW1@206350|Nitrosomonadales	206350|Nitrosomonadales	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_4,Phage_integrase
HKD3_k127_8700604_21	331678.Cphamn1_1944	2.24e-18	87.0	COG2827@1|root,COG2827@2|Bacteria	2|Bacteria	L	Endonuclease containing a URI domain	yazA	-	-	ko:K07461	-	-	-	-	ko00000	-	-	-	GIY-YIG
HKD3_k127_8700604_20	497964.CfE428DRAFT_2905	1.671e-19	92.0	COG4974@1|root,COG4974@2|Bacteria	2|Bacteria	L	Belongs to the 'phage' integrase family	-	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_4,Phage_integrase
HKD3_k127_8700604_18	42256.RradSPS_2313	1.121e-28	120.0	COG3791@1|root,COG3791@2|Bacteria	2|Bacteria	S	Glutathione-dependent formaldehyde-activating	-	-	-	-	-	-	-	-	-	-	-	-	GFA
HKD3_k127_8700604_12	1501230.ET33_35580	1.325e-48	179.0	COG1670@1|root,COG1670@2|Bacteria,1VQDG@1239|Firmicutes,4HHTI@91061|Bacilli,272NM@186822|Paenibacillaceae	91061|Bacilli	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
HKD3_k127_8700604_26	743721.Psesu_0008	2.196e-05	55.0	COG0810@1|root,COG0810@2|Bacteria,1MZPX@1224|Proteobacteria,1S7VF@1236|Gammaproteobacteria,1X54J@135614|Xanthomonadales	135614|Xanthomonadales	M	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins	tonB1	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	TonB_C
HKD3_k127_8700604_14	1121413.JMKT01000010_gene852	5.651e-45	166.0	COG0824@1|root,COG0824@2|Bacteria,1RI3X@1224|Proteobacteria,42SW5@68525|delta/epsilon subdivisions,2WW97@28221|Deltaproteobacteria,2MBHH@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Acyl-ACP thioesterase	-	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	Acyl-ACP_TE
HKD3_k127_8700604_6	497964.CfE428DRAFT_6325	9.471e-111	367.0	COG0438@1|root,COG0438@2|Bacteria,46TH7@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
HKD3_k127_8857815_0	344747.PM8797T_02634	1.068e-84	285.0	COG0491@1|root,COG0491@2|Bacteria,2IXNH@203682|Planctomycetes	203682|Planctomycetes	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_8857815_1	648996.Theam_1293	8.921e-57	209.0	COG0846@1|root,COG0846@2|Bacteria,2G412@200783|Aquificae	200783|Aquificae	K	modulates the activities of several proteins which are inactive in their	cobB	-	-	ko:K12410	-	-	-	-	ko00000,ko01000	-	-	-	SIR2
HKD3_k127_8857815_2	96561.Dole_0419	2.837e-40	157.0	COG3184@1|root,COG3184@2|Bacteria,1NBCP@1224|Proteobacteria,430D8@68525|delta/epsilon subdivisions,2WVR4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Uncharacterized protein conserved in bacteria (DUF2059)	-	-	-	ko:K09924	-	-	-	-	ko00000	-	-	-	DUF2059
HKD3_k127_8857815_3	1121920.AUAU01000007_gene416	5.151e-23	98.0	COG1164@1|root,COG1164@2|Bacteria,3Y2SB@57723|Acidobacteria	57723|Acidobacteria	E	Angiotensin-converting enzyme	-	-	3.4.15.1	ko:K01283	ko04614,ko04924,ko05142,ko05410,map04614,map04924,map05142,map05410	-	-	-	ko00000,ko00001,ko01000,ko01002,ko04090,ko04147	-	-	-	Peptidase_M2
HKD3_k127_8898502_2	1183438.GKIL_4354	2.233e-182	598.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HKD3_k127_8898502_3	452637.Oter_1883	1.17e-175	580.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HKD3_k127_8898502_4	251221.35211765	2.147e-173	572.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HKD3_k127_8898502_9	452637.Oter_1900	3.966e-111	363.0	COG1136@1|root,COG1136@2|Bacteria,46TVQ@74201|Verrucomicrobia	74201|Verrucomicrobia	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD3_k127_8898502_7	452637.Oter_1901	2.702e-135	447.0	COG0845@1|root,COG0845@2|Bacteria,46UK7@74201|Verrucomicrobia	74201|Verrucomicrobia	M	HlyD family secretion protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_8898502_6	234267.Acid_4169	1.714e-154	499.0	COG5000@1|root,COG5000@2|Bacteria,3Y2TD@57723|Acidobacteria	57723|Acidobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c
HKD3_k127_8898502_5	926566.Terro_2393	2.295e-155	508.0	COG2204@1|root,COG2204@2|Bacteria,3Y33M@57723|Acidobacteria,2JHW9@204432|Acidobacteriia	204432|Acidobacteriia	T	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD3_k127_8898502_8	481448.Minf_2378	2.482e-117	389.0	COG1633@1|root,COG1814@1|root,COG1633@2|Bacteria,COG1814@2|Bacteria,46WTS@74201|Verrucomicrobia,37G3H@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	S	VIT family	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin,VIT1
HKD3_k127_8898502_11	1227739.Hsw_3882	2.976e-77	271.0	COG0697@1|root,COG0697@2|Bacteria,4NGJR@976|Bacteroidetes,47N5J@768503|Cytophagia	976|Bacteroidetes	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HKD3_k127_8898502_14	1267535.KB906767_gene508	1.896e-22	98.0	COG2261@1|root,COG2261@2|Bacteria,3Y5KH@57723|Acidobacteria,2JNHS@204432|Acidobacteriia	204432|Acidobacteriia	S	Transglycosylase associated protein	-	-	-	-	-	-	-	-	-	-	-	-	Transgly_assoc
HKD3_k127_8898502_1	497964.CfE428DRAFT_5481	1.08e-228	719.0	COG1052@1|root,COG1052@2|Bacteria,46SAN@74201|Verrucomicrobia	74201|Verrucomicrobia	CH	D-isomer specific 2-hydroxyacid dehydrogenase	-	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C,ACT
HKD3_k127_8898502_13	1267533.KB906733_gene3151	6.799e-72	250.0	2CDI3@1|root,3416N@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_8898502_15	1267533.KB906733_gene3151	3.097e-21	105.0	2CDI3@1|root,3416N@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_8898502_0	497964.CfE428DRAFT_0232	2.603e-237	749.0	COG0531@1|root,COG0531@2|Bacteria	2|Bacteria	E	amino acid	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_8898502_12	478741.JAFS01000001_gene1841	5.238e-74	256.0	COG0745@1|root,COG0745@2|Bacteria,46UC4@74201|Verrucomicrobia,37G00@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	T	Transcriptional regulatory protein, C terminal	kdpE	-	-	ko:K07667	ko02020,ko02024,map02020,map02024	M00454	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
HKD3_k127_8898502_10	1403819.BATR01000007_gene216	7.362e-105	360.0	COG0642@1|root,COG2205@2|Bacteria,46UHY@74201|Verrucomicrobia,2ITGS@203494|Verrucomicrobiae	203494|Verrucomicrobiae	T	Osmosensitive K+ channel His kinase sensor domain	-	-	2.7.13.3	ko:K07646	ko02020,map02020	M00454	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	DUF4118,HATPase_c,HisKA,KdpD,Usp
HKD3_k127_893218_5	1122604.JONR01000031_gene1279	5.148e-108	384.0	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1T5SE@1236|Gammaproteobacteria,1XDE6@135614|Xanthomonadales	135614|Xanthomonadales	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_19
HKD3_k127_893218_10	497964.CfE428DRAFT_1875	2.768e-58	231.0	COG0515@1|root,COG1262@1|root,COG0515@2|Bacteria,COG1262@2|Bacteria	2|Bacteria	T	PFAM Formylglycine-generating sulfatase enzyme	-	-	-	-	-	-	-	-	-	-	-	-	DUF4062,FGE-sulfatase,Metallophos,NACHT,PEGA,Pkinase
HKD3_k127_893218_12	497964.CfE428DRAFT_4864	2.877e-50	187.0	COG1595@1|root,COG1595@2|Bacteria,46VE8@74201|Verrucomicrobia	74201|Verrucomicrobia	K	DNA-templated transcription, initiation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_893218_13	1056820.KB900700_gene1015	1.103e-47	177.0	COG0454@1|root,COG0456@2|Bacteria,1QU0C@1224|Proteobacteria,1S503@1236|Gammaproteobacteria,2PPW4@256005|Alteromonadales genera incertae sedis	1236|Gammaproteobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HKD3_k127_893218_22	485913.Krac_9387	2.126e-31	129.0	COG4319@1|root,COG4319@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red,SnoaL_3
HKD3_k127_893218_4	1122604.JONR01000031_gene1279	1.896e-120	411.0	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1T5SE@1236|Gammaproteobacteria,1XDE6@135614|Xanthomonadales	135614|Xanthomonadales	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_19
HKD3_k127_893218_25	1207058.L53_14300	9.413e-24	104.0	COG3631@1|root,COG3631@2|Bacteria,1N487@1224|Proteobacteria,2UBRI@28211|Alphaproteobacteria,43YDG@69657|Hyphomonadaceae	28211|Alphaproteobacteria	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_2
HKD3_k127_893218_21	1472716.KBK24_0112150	1.589e-31	128.0	COG3832@1|root,COG3832@2|Bacteria,1RI7Y@1224|Proteobacteria,2VW09@28216|Betaproteobacteria,1K8QR@119060|Burkholderiaceae	28216|Betaproteobacteria	O	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
HKD3_k127_893218_14	1121373.KB903624_gene2431	4.326e-47	173.0	COG3832@1|root,COG3832@2|Bacteria,4NST9@976|Bacteroidetes,47R8V@768503|Cytophagia	976|Bacteroidetes	S	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
HKD3_k127_893218_15	436308.Nmar_0233	1.89e-38	147.0	COG3324@1|root,arCOG04946@2157|Archaea,41T3T@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Glyoxalase bleomycin resistance protein dioxygenase	-	-	-	ko:K06996	-	-	-	-	ko00000	-	-	-	-
HKD3_k127_893218_6	296591.Bpro_1368	1.173e-94	316.0	COG4312@1|root,COG4312@2|Bacteria,1NAXN@1224|Proteobacteria,2VK34@28216|Betaproteobacteria,4AG99@80864|Comamonadaceae	28216|Betaproteobacteria	S	Bacterial protein of unknown function (DUF899)	-	-	-	-	-	-	-	-	-	-	-	-	DUF899
HKD3_k127_893218_17	1396418.BATQ01000144_gene3441	1.066e-36	143.0	COG0640@1|root,COG0640@2|Bacteria,46T9N@74201|Verrucomicrobia,2IVWD@203494|Verrucomicrobiae	203494|Verrucomicrobiae	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
HKD3_k127_893218_2	204669.Acid345_2236	2.787e-173	550.0	COG1052@1|root,COG1052@2|Bacteria,3Y8C1@57723|Acidobacteria,2JNCS@204432|Acidobacteriia	204432|Acidobacteriia	CH	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	2-Hacid_dh,2-Hacid_dh_C
HKD3_k127_893218_19	1095750.HMPREF9970_1402	5.252e-35	142.0	COG0637@1|root,COG0637@2|Bacteria,1V1DF@1239|Firmicutes,24FYY@186801|Clostridia,1HV3Z@1164882|Lachnoanaerobaculum	186801|Clostridia	S	NLI interacting factor-like phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
HKD3_k127_893218_18	941449.dsx2_1298	2.251e-35	149.0	COG2203@1|root,COG3920@1|root,COG4191@1|root,COG2203@2|Bacteria,COG3920@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42M1R@68525|delta/epsilon subdivisions,2WJ5T@28221|Deltaproteobacteria,2MHID@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	Cache domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS_3,PAS_4,Response_reg,dCache_1
HKD3_k127_893218_24	596151.DesfrDRAFT_2779	1.338e-27	117.0	COG2206@1|root,COG3707@1|root,COG2206@2|Bacteria,COG3707@2|Bacteria,1RAQS@1224|Proteobacteria,42MEJ@68525|delta/epsilon subdivisions,2WW4F@28221|Deltaproteobacteria,2MG1H@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,HD,PAS,PAS_4,Response_reg
HKD3_k127_893218_16	426117.M446_4758	9.115e-38	147.0	COG1917@1|root,COG1917@2|Bacteria,1MUY3@1224|Proteobacteria,2U5R0@28211|Alphaproteobacteria,1JV2T@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	ChrR Cupin-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_7
HKD3_k127_893218_0	204669.Acid345_2243	5.329e-195	614.0	COG0436@1|root,COG0436@2|Bacteria,3Y3DG@57723|Acidobacteria,2JMAM@204432|Acidobacteriia	204432|Acidobacteriia	E	Aminotransferase class I and II	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
HKD3_k127_893218_3	497964.CfE428DRAFT_4053	6.592e-142	456.0	COG1409@1|root,COG1409@2|Bacteria	2|Bacteria	S	acid phosphatase activity	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
HKD3_k127_893218_11	497964.CfE428DRAFT_4052	2.576e-56	201.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD3_k127_893218_9	485913.Krac_10225	8.944e-61	220.0	COG5662@1|root,COG5662@2|Bacteria	2|Bacteria	K	AntiSigma factor	-	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
HKD3_k127_893218_20	1300143.CCAV010000011_gene2807	2.607e-32	131.0	COG0346@1|root,COG0346@2|Bacteria,4NRRB@976|Bacteroidetes,1I2PP@117743|Flavobacteriia,3ZRNX@59732|Chryseobacterium	976|Bacteroidetes	E	Glyoxalase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HKD3_k127_893218_8	240016.ABIZ01000001_gene1288	2.836e-69	237.0	COG0662@1|root,COG0662@2|Bacteria,46V2V@74201|Verrucomicrobia	74201|Verrucomicrobia	G	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HKD3_k127_893218_1	941449.dsx2_2869	5.607e-177	564.0	COG0366@1|root,COG0366@2|Bacteria,1MX9V@1224|Proteobacteria,4316S@68525|delta/epsilon subdivisions,2WWX2@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	Alpha-amylase C-terminal beta-sheet domain	-	-	3.2.1.1	ko:K01176	ko00500,ko01100,ko04973,map00500,map01100,map04973	-	R02108,R02112,R11262	-	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amyl_C2,Alpha-amylase
HKD3_k127_893218_27	497964.CfE428DRAFT_1170	7.397e-12	65.0	COG3011@1|root,COG3011@2|Bacteria,46U84@74201|Verrucomicrobia	2|Bacteria	S	Lipase maturation factor	LMF	-	-	-	-	-	-	-	-	-	-	-	LMF1
HKD3_k127_9057443_19	1191523.MROS_1530	1.979e-32	133.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria	2|Bacteria	E	serine-type peptidase activity	-	-	3.4.14.5	ko:K01278	ko04974,map04974	-	-	-	ko00000,ko00001,ko01000,ko01002,ko04090,ko04147	-	-	-	DPPIV_N,PD40,Peptidase_S9
HKD3_k127_9057443_14	204669.Acid345_4193	3.791e-90	311.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,3Y3IB@57723|Acidobacteria,2JKJ2@204432|Acidobacteriia	204432|Acidobacteriia	EU	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
HKD3_k127_9057443_23	1267533.KB906735_gene4559	1.319e-18	87.0	COG3369@1|root,COG3369@2|Bacteria,3Y5KG@57723|Acidobacteria,2JJXU@204432|Acidobacteriia	204432|Acidobacteriia	S	PFAM Iron sulphur-containing domain, CDGSH-type	-	-	-	-	-	-	-	-	-	-	-	-	zf-CDGSH
HKD3_k127_9057443_25	1454007.JAUG01000090_gene705	5.628e-14	76.0	COG1502@1|root,COG1502@2|Bacteria,4NMXS@976|Bacteroidetes,1ISBY@117747|Sphingobacteriia	976|Bacteroidetes	I	ORF6N domain	-	-	-	-	-	-	-	-	-	-	-	-	ORF6N
HKD3_k127_9057443_22	671143.DAMO_2744	3.573e-22	98.0	COG0449@1|root,COG0449@2|Bacteria	2|Bacteria	M	glutamine-fructose-6-phosphate transaminase (isomerizing) activity	-	-	-	-	-	-	-	-	-	-	-	-	ORF6N,SIS
HKD3_k127_9057443_10	309807.SRU_2814	2.155e-128	425.0	COG1228@1|root,COG4538@1|root,COG1228@2|Bacteria,COG4538@2|Bacteria,4PHV0@976|Bacteroidetes,1FJM6@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1,SnoaL_2
HKD3_k127_9057443_6	478741.JAFS01000001_gene1797	1.229e-146	468.0	COG2897@1|root,COG2897@2|Bacteria,46SFU@74201|Verrucomicrobia,37G92@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	P	Rhodanese Homology Domain	-	-	2.8.1.1,2.8.1.2	ko:K01011	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko01000	-	-	-	Rhodanese
HKD3_k127_9057443_2	497964.CfE428DRAFT_3903	3.843e-189	606.0	COG1640@1|root,COG1640@2|Bacteria,46SX0@74201|Verrucomicrobia	74201|Verrucomicrobia	G	PFAM glycoside hydrolase family 77	malQ	-	2.4.1.25	ko:K00705	ko00500,ko01100,map00500,map01100	-	R05196	RC00049	ko00000,ko00001,ko01000	-	GH77	-	Glyco_hydro_77
HKD3_k127_9057443_21	1166018.FAES_4249	1.778e-26	115.0	COG0614@1|root,COG0614@2|Bacteria,4NTHD@976|Bacteroidetes,47RTX@768503|Cytophagia	976|Bacteroidetes	P	PD-(D/E)XK nuclease superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_3
HKD3_k127_9057443_1	497964.CfE428DRAFT_3901	6.043e-283	885.0	COG0210@1|root,COG0210@2|Bacteria,46S8H@74201|Verrucomicrobia	74201|Verrucomicrobia	L	PFAM UvrD REP helicase	uvrD	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
HKD3_k127_9057443_0	497964.CfE428DRAFT_4831	2.683e-284	884.0	COG0821@1|root,COG0821@2|Bacteria,46SEF@74201|Verrucomicrobia	74201|Verrucomicrobia	I	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate	ispG	-	1.17.7.1,1.17.7.3	ko:K03526	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R08689,R10859	RC01486	ko00000,ko00001,ko00002,ko01000	-	-	-	GcpE
HKD3_k127_9057443_4	1156937.MFUM_700088	1.075e-155	504.0	COG0750@1|root,COG0750@2|Bacteria,46S9B@74201|Verrucomicrobia,37G4E@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	M	Peptidase family M50	-	-	-	ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_M50
HKD3_k127_9057443_3	1403819.BATR01000096_gene3146	4.18e-157	504.0	COG0743@1|root,COG0743@2|Bacteria,46S90@74201|Verrucomicrobia,2ITI1@203494|Verrucomicrobiae	203494|Verrucomicrobiae	I	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal	dxr	-	1.1.1.267	ko:K00099	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05688	RC01452	ko00000,ko00001,ko00002,ko01000	-	-	-	DXPR_C,DXP_redisom_C,DXP_reductoisom
HKD3_k127_9057443_20	278957.ABEA03000041_gene2220	4.446e-30	122.0	COG0614@1|root,COG0614@2|Bacteria,46XIV@74201|Verrucomicrobia,3KA1P@414999|Opitutae	414999|Opitutae	P	PD-(D/E)XK nuclease superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_3
HKD3_k127_9057443_11	497964.CfE428DRAFT_4834	4.876e-118	386.0	COG4589@1|root,COG4589@2|Bacteria,46SX9@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Cytidylyltransferase family	-	-	2.7.7.41	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_1
HKD3_k127_9057443_24	1121861.KB899912_gene966	1.003e-15	80.0	COG0558@1|root,COG0558@2|Bacteria,1RHFC@1224|Proteobacteria,2UACA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	cdp-diacylglycerol--glycerol-3-phosphate	pgsAb	-	-	-	-	-	-	-	-	-	-	-	CDP-OH_P_transf
HKD3_k127_9057443_13	1123060.JONP01000001_gene1304	1.024e-100	337.0	COG4589@1|root,COG4589@2|Bacteria,1MX58@1224|Proteobacteria,2TT9I@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Phosphatidate cytidylyltransferase	cdsA2	-	2.7.7.41	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_1
HKD3_k127_9057443_15	886293.Sinac_7153	1.171e-75	262.0	COG0204@1|root,COG0204@2|Bacteria,2IWS6@203682|Planctomycetes	203682|Planctomycetes	I	Acyltransferase	-	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
HKD3_k127_9057443_7	478741.JAFS01000002_gene242	4.226e-142	463.0	COG2262@1|root,COG2262@2|Bacteria,46SP4@74201|Verrucomicrobia,37FVB@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	S	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis	hflX	-	-	ko:K03665	-	-	-	-	ko00000,ko03009	-	-	-	GTP-bdg_M,GTP-bdg_N,MMR_HSR1
HKD3_k127_9057443_16	497964.CfE428DRAFT_2338	2.632e-70	249.0	COG0324@1|root,COG0324@2|Bacteria,46T1C@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)	miaA	-	2.5.1.75	ko:K00791	ko00908,ko01100,ko01110,map00908,map01100,map01110	-	R01122	RC02820	ko00000,ko00001,ko01000,ko01006,ko03016	-	-	-	IPPT
HKD3_k127_9057443_12	497964.CfE428DRAFT_1893	1.592e-104	345.0	COG0149@1|root,COG0149@2|Bacteria,46SNB@74201|Verrucomicrobia	74201|Verrucomicrobia	G	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)	tpiA	-	5.3.1.1	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01015	RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	TIM
HKD3_k127_9057443_9	240015.ACP_0631	5.588e-134	438.0	COG0126@1|root,COG0126@2|Bacteria,3Y2T7@57723|Acidobacteria,2JI0Z@204432|Acidobacteriia	204432|Acidobacteriia	F	Belongs to the phosphoglycerate kinase family	pgk	-	2.7.2.3	ko:K00927	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01512	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
HKD3_k127_9057443_8	1123070.KB899249_gene286	1.57e-139	450.0	COG0057@1|root,COG0057@2|Bacteria,46S59@74201|Verrucomicrobia,2ITXT@203494|Verrucomicrobiae	203494|Verrucomicrobiae	G	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain	-	-	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Gp_dh_C,Gp_dh_N
HKD3_k127_9057443_17	1519464.HY22_13075	9.142e-54	196.0	COG2755@1|root,COG2755@2|Bacteria,1FET3@1090|Chlorobi	1090|Chlorobi	E	GDSL-like Lipase/Acylhydrolase family	-	-	3.1.1.5	ko:K10804	ko01040,map01040	-	-	-	ko00000,ko00001,ko01000,ko01004	-	-	-	Lipase_GDSL_2
HKD3_k127_9057443_26	742159.HMPREF0004_3643	1.615e-10	65.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,2VH8J@28216|Betaproteobacteria,3T1BJ@506|Alcaligenaceae	28216|Betaproteobacteria	P	P-type ATPase	actP_2	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
HKD3_k127_9057443_5	497964.CfE428DRAFT_2962	3.413e-155	496.0	COG2957@1|root,COG2957@2|Bacteria,46SAM@74201|Verrucomicrobia	74201|Verrucomicrobia	E	Belongs to the agmatine deiminase family	-	-	3.5.3.12	ko:K10536	ko00330,ko01100,map00330,map01100	-	R01416	RC00177	ko00000,ko00001,ko01000	-	-	-	PAD_porph
HKD3_k127_9057443_18	497964.CfE428DRAFT_5652	5.156e-47	171.0	2A8AI@1|root,30XBY@2|Bacteria,46SPH@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_9077580_1	452637.Oter_1899	2.745e-77	263.0	COG0577@1|root,COG0577@2|Bacteria,46TJI@74201|Verrucomicrobia	2|Bacteria	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HKD3_k127_9077580_5	497964.CfE428DRAFT_0066	2.832e-06	49.0	COG0515@1|root,COG1262@1|root,COG0515@2|Bacteria,COG1262@2|Bacteria,46TTW@74201|Verrucomicrobia	74201|Verrucomicrobia	KLT	Sulfatase-modifying factor enzyme 1	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase,PEGA,Pkinase
HKD3_k127_9077580_4	497964.CfE428DRAFT_0066	9.973e-07	51.0	COG0515@1|root,COG1262@1|root,COG0515@2|Bacteria,COG1262@2|Bacteria,46TTW@74201|Verrucomicrobia	74201|Verrucomicrobia	KLT	Sulfatase-modifying factor enzyme 1	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase,PEGA,Pkinase
HKD3_k127_9077580_3	497964.CfE428DRAFT_1422	2.463e-20	92.0	COG0230@1|root,COG0230@2|Bacteria,46WMF@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Ribosomal protein L34	rpmH	-	-	ko:K02914	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L34
HKD3_k127_9077580_2	497964.CfE428DRAFT_1441	1.497e-52	191.0	COG0454@1|root,COG0456@2|Bacteria,46T1U@74201|Verrucomicrobia	74201|Verrucomicrobia	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HKD3_k127_9077580_0	251221.35211291	2.753e-109	368.0	COG0308@1|root,COG0308@2|Bacteria,1G03V@1117|Cyanobacteria	1117|Cyanobacteria	CE	aminopeptidase N	pepN	-	3.4.11.2	ko:K01256	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	DUF3458,DUF3458_C,Peptidase_M1
HKD3_k127_9118740_0	743722.Sph21_0379	0.0	1360.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,4NFRF@976|Bacteroidetes,1IR6C@117747|Sphingobacteriia	976|Bacteroidetes	E	Methionine synthase	metH	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
HKD3_k127_91378_7	204669.Acid345_3443	6.121e-81	276.0	COG1574@1|root,COG1574@2|Bacteria,3Y2UF@57723|Acidobacteria,2JIRH@204432|Acidobacteriia	204432|Acidobacteriia	S	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
HKD3_k127_91378_11	44251.PDUR_02070	2.875e-33	133.0	COG0454@1|root,COG0456@2|Bacteria,1V4GU@1239|Firmicutes,4HQNT@91061|Bacilli,26XKA@186822|Paenibacillaceae	91061|Bacilli	K	GCN5 family acetyltransferase	-	-	2.3.1.1	ko:K22477	ko00220,ko01210,ko01230,map00220,map01210,map01230	M00028	R00259	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetyltransf_1
HKD3_k127_91378_0	926550.CLDAP_08980	7.446e-159	508.0	COG0182@1|root,COG0182@2|Bacteria,2G5Z3@200795|Chloroflexi	200795|Chloroflexi	J	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)	mtnA	-	5.3.1.23	ko:K08963	ko00270,ko01100,map00270,map01100	M00034	R04420	RC01151	ko00000,ko00001,ko00002,ko01000	-	-	-	IF-2B
HKD3_k127_91378_10	1128427.KB904821_gene3730	9.184e-47	177.0	COG0235@1|root,COG0235@2|Bacteria,1G59N@1117|Cyanobacteria,1HANS@1150|Oscillatoriales	1117|Cyanobacteria	G	Class II Aldolase and Adducin N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Aldolase_II
HKD3_k127_91378_1	404589.Anae109_1564	1.738e-129	422.0	COG0667@1|root,COG0667@2|Bacteria,1MVEH@1224|Proteobacteria,42MDR@68525|delta/epsilon subdivisions,2WKUR@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	aldo keto reductase	-	-	1.1.1.65	ko:K05275	ko00750,ko01100,ko01120,map00750,map01100,map01120	-	R01708	RC00116	ko00000,ko00001,ko01000	-	-	-	Aldo_ket_red
HKD3_k127_91378_12	477184.KYC_19554	5.369e-30	129.0	2C3WA@1|root,2Z8P1@2|Bacteria,1R8VC@1224|Proteobacteria,2VQ8D@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_91378_6	1396418.BATQ01000110_gene4753	1.814e-83	293.0	29D6U@1|root,3004T@2|Bacteria,46VBG@74201|Verrucomicrobia,2IUVG@203494|Verrucomicrobiae	203494|Verrucomicrobiae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_91378_3	240016.ABIZ01000001_gene2096	3.164e-119	391.0	28HK0@1|root,2Z7V0@2|Bacteria,46TSH@74201|Verrucomicrobia,2IU3Q@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Domain of unknown function (DUF4105)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4105
HKD3_k127_91378_2	1267534.KB906754_gene2900	1.3e-122	404.0	COG4786@1|root,COG4786@2|Bacteria,3Y68I@57723|Acidobacteria,2JMAD@204432|Acidobacteriia	204432|Acidobacteriia	N	Protein of unknown function (DUF2950)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2950
HKD3_k127_91378_5	1267534.KB906755_gene3906	2.656e-85	302.0	COG3064@1|root,COG3064@2|Bacteria,3Y6QP@57723|Acidobacteria	57723|Acidobacteria	M	Protein of unknown function (DUF3300)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3300
HKD3_k127_91378_13	1266925.JHVX01000013_gene1657	4.278e-21	98.0	COG2885@1|root,COG2885@2|Bacteria,1N6EM@1224|Proteobacteria,2VM27@28216|Betaproteobacteria,371W8@32003|Nitrosomonadales	28216|Betaproteobacteria	M	Belongs to the ompA family	-	-	-	ko:K03286	-	-	-	-	ko00000,ko02000	1.B.6	-	-	OmpA
HKD3_k127_91378_8	1254432.SCE1572_28790	1.232e-75	261.0	2C3WA@1|root,2Z8P1@2|Bacteria,1R8VC@1224|Proteobacteria,43E08@68525|delta/epsilon subdivisions,2WZBV@28221|Deltaproteobacteria,2Z1SW@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_91378_9	635013.TherJR_2349	4.762e-71	245.0	COG0205@1|root,COG0205@2|Bacteria,1TPF4@1239|Firmicutes,249AM@186801|Clostridia,2607Y@186807|Peptococcaceae	186801|Clostridia	F	Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis	pfkA2	-	2.7.1.11,2.7.1.90	ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
HKD3_k127_9143528_0	1123073.KB899241_gene3395	3.126e-221	690.0	COG0624@1|root,COG0624@2|Bacteria,1R96A@1224|Proteobacteria,1RSD6@1236|Gammaproteobacteria,1X5K9@135614|Xanthomonadales	135614|Xanthomonadales	E	Peptidase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
HKD3_k127_9143528_3	1403819.BATR01000124_gene4368	1.357e-28	119.0	COG1917@1|root,COG1917@2|Bacteria,46Z3I@74201|Verrucomicrobia,2IW0C@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Cupin	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HKD3_k127_9143528_2	1121405.dsmv_1643	2.299e-46	171.0	COG1764@1|root,COG1764@2|Bacteria,1RH9U@1224|Proteobacteria,42TWN@68525|delta/epsilon subdivisions,2WQDD@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	OsmC-like protein	osmC	-	-	ko:K04063	-	-	-	-	ko00000	-	-	-	OsmC
HKD3_k127_9143528_4	1382359.JIAL01000001_gene418	3.816e-22	102.0	COG0454@1|root,COG0456@2|Bacteria,3Y5G1@57723|Acidobacteria,2JJWU@204432|Acidobacteriia	204432|Acidobacteriia	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HKD3_k127_9143528_1	379066.GAU_3766	2.074e-48	178.0	COG3202@1|root,COG3202@2|Bacteria,1ZURB@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	TLC ATP/ADP transporter	-	-	-	ko:K03301	-	-	-	-	ko00000	2.A.12	-	-	TLC
HKD3_k127_9214737_3	1122604.JONR01000031_gene1279	5.231e-91	317.0	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1T5SE@1236|Gammaproteobacteria,1XDE6@135614|Xanthomonadales	135614|Xanthomonadales	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_19
HKD3_k127_9214737_11	344747.PM8797T_24461	4.003e-16	79.0	COG0589@1|root,COG0589@2|Bacteria,2J042@203682|Planctomycetes	203682|Planctomycetes	T	COG0589 Universal stress protein UspA and related nucleotide-binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD3_k127_9214737_12	768710.DesyoDRAFT_1628	1.741e-06	53.0	COG0589@1|root,COG0589@2|Bacteria,1VEJR@1239|Firmicutes,24P7X@186801|Clostridia	186801|Clostridia	T	PFAM Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD3_k127_9214737_2	383372.Rcas_1801	5.072e-100	342.0	COG2308@1|root,COG2308@2|Bacteria,2G7ZB@200795|Chloroflexi,3754D@32061|Chloroflexia	32061|Chloroflexia	S	Evidence 4 Homologs of previously reported genes of	-	-	-	-	-	-	-	-	-	-	-	-	CP_ATPgrasp_2
HKD3_k127_9214737_4	452637.Oter_0906	1.978e-80	274.0	COG0664@1|root,COG0664@2|Bacteria,46VK1@74201|Verrucomicrobia,3K7W4@414999|Opitutae	74201|Verrucomicrobia	K	Crp Fnr family	-	-	-	ko:K21563	-	-	-	-	ko00000,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
HKD3_k127_9214737_8	1121875.KB907550_gene772	1.456e-48	181.0	COG0500@1|root,COG0500@2|Bacteria,4PM90@976|Bacteroidetes,1IJN7@117743|Flavobacteriia	976|Bacteroidetes	Q	Protein of unknown function (DUF1698)	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
HKD3_k127_9214737_5	497964.CfE428DRAFT_5882	1.81e-69	251.0	COG3213@1|root,COG3213@2|Bacteria,46VTH@74201|Verrucomicrobia	74201|Verrucomicrobia	P	NnrS protein	-	-	-	-	-	-	-	-	-	-	-	-	NnrS
HKD3_k127_9214737_10	452637.Oter_0905	1.209e-22	102.0	COG4309@1|root,COG4309@2|Bacteria,46YQI@74201|Verrucomicrobia,3KA04@414999|Opitutae	414999|Opitutae	S	Uncharacterized conserved protein (DUF2249)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2249
HKD3_k127_9214737_9	794903.OPIT5_23125	2.677e-31	133.0	2C4QH@1|root,34C9E@2|Bacteria,46XU0@74201|Verrucomicrobia,3K83D@414999|Opitutae	414999|Opitutae	-	-	-	-	-	ko:K01992,ko:K19341	ko02010,map02010	M00254,M00762	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.132.2	-	-	-
HKD3_k127_9214737_7	309807.SRU_0311	1.152e-59	216.0	COG1131@1|root,COG1131@2|Bacteria,4PER8@976|Bacteroidetes,1FJGQ@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD3_k127_9214737_1	278957.ABEA03000176_gene2845	1.157e-113	385.0	COG3420@1|root,COG3420@2|Bacteria,46VQ1@74201|Verrucomicrobia,3K7SA@414999|Opitutae	414999|Opitutae	P	Domain present in carbohydrate binding proteins and sugar hydrolses	-	-	-	ko:K07218	-	-	-	-	ko00000	-	-	-	NosD
HKD3_k127_9214737_6	794903.OPIT5_23140	3.06e-68	237.0	COG4314@1|root,COG4314@2|Bacteria,46WQY@74201|Verrucomicrobia,3K7YT@414999|Opitutae	414999|Opitutae	C	lipoprotein involved in nitrous oxide reduction	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_9214737_0	794903.OPIT5_23145	1.344e-310	958.0	COG4263@1|root,COG4263@2|Bacteria,46YT5@74201|Verrucomicrobia,3K7SZ@414999|Opitutae	414999|Opitutae	C	Cupredoxin-like domain	-	-	1.7.2.4	ko:K00376	ko00910,ko01120,map00910,map01120	M00529	R02804	RC02861	ko00000,ko00001,ko00002,ko01000	-	-	-	Cupredoxin_1
HKD3_k127_9238343_1	497964.CfE428DRAFT_0944	7.522e-95	328.0	COG4258@1|root,COG4258@2|Bacteria,46TC6@74201|Verrucomicrobia	2|Bacteria	S	MMPL family	hpnN	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
HKD3_k127_9238343_0	497964.CfE428DRAFT_0942	3.292e-139	454.0	COG0644@1|root,COG0644@2|Bacteria,46SNH@74201|Verrucomicrobia	74201|Verrucomicrobia	C	Tryptophan halogenase	-	-	-	-	-	-	-	-	-	-	-	-	Trp_halogenase
HKD3_k127_9325778_5	886293.Sinac_6834	1.236e-53	194.0	COG1764@1|root,COG1764@2|Bacteria	2|Bacteria	O	response to oxidative stress	ymaD	-	-	ko:K04063	-	-	-	-	ko00000	-	-	-	OsmC
HKD3_k127_9325778_0	452637.Oter_0818	1.197e-214	673.0	COG0334@1|root,COG0334@2|Bacteria,46UBX@74201|Verrucomicrobia,3K7SK@414999|Opitutae	414999|Opitutae	E	Belongs to the Glu Leu Phe Val dehydrogenases family	-	-	1.4.1.4	ko:K00262	ko00220,ko00250,ko00910,ko01100,map00220,map00250,map00910,map01100	-	R00248	RC00006,RC02799	ko00000,ko00001,ko01000	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
HKD3_k127_9325778_10	1408419.JHYG01000001_gene1721	0.0002075	48.0	2EQUD@1|root,33IE5@2|Bacteria,1NN93@1224|Proteobacteria	2|Bacteria	S	YXWGXW repeat (2 copies)	-	-	-	-	-	-	-	-	-	-	-	-	YXWGXW
HKD3_k127_9325778_2	439235.Dalk_2978	1.013e-109	359.0	COG1216@1|root,COG1216@2|Bacteria,1R50T@1224|Proteobacteria,42P74@68525|delta/epsilon subdivisions,2WK88@28221|Deltaproteobacteria,2MJIE@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2,Methyltransf_23
HKD3_k127_9325778_3	452637.Oter_0860	9.599e-91	307.0	COG0123@1|root,COG0123@2|Bacteria,46SMT@74201|Verrucomicrobia	74201|Verrucomicrobia	BQ	Histone deacetylase domain	acuC	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
HKD3_k127_9325778_6	591159.ACEZ01000158_gene5593	5.38e-32	131.0	2BARS@1|root,3246W@2|Bacteria,2IM0H@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_9325778_8	58344.JOEL01000044_gene886	9.944e-06	49.0	COG2267@1|root,COG2267@2|Bacteria,2GPA8@201174|Actinobacteria	201174|Actinobacteria	I	hydrolase	-	-	3.1.1.5	ko:K01048	ko00564,map00564	-	-	-	ko00000,ko00001,ko01000	-	-	-	Hydrolase_4
HKD3_k127_9325778_1	497964.CfE428DRAFT_0747	8.733e-170	539.0	COG0012@1|root,COG0012@2|Bacteria,46S8D@74201|Verrucomicrobia	74201|Verrucomicrobia	J	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner	ychF	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,YchF-GTPase_C
HKD3_k127_9325778_4	497964.CfE428DRAFT_3472	3.465e-60	215.0	COG1579@1|root,COG1579@2|Bacteria,46T10@74201|Verrucomicrobia	74201|Verrucomicrobia	S	C4-type zinc ribbon domain	-	-	-	ko:K07164	-	-	-	-	ko00000	-	-	-	zf-RING_7
HKD3_k127_9325778_7	235279.HH_1544	7.297e-10	64.0	COG0450@1|root,COG0450@2|Bacteria,1MWPY@1224|Proteobacteria,42MAJ@68525|delta/epsilon subdivisions,2YMW0@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	O	Alkyl hydroperoxide reductase	ahpC	-	1.11.1.15	ko:K03386	ko04214,map04214	-	-	-	ko00000,ko00001,ko01000,ko04147	-	-	-	1-cysPrx_C,AhpC-TSA
HKD3_k127_9325778_9	1382306.JNIM01000001_gene293	0.0001416	44.0	COG1225@1|root,COG1225@2|Bacteria,2G8QZ@200795|Chloroflexi	200795|Chloroflexi	O	PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	-	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
HKD3_k127_9349792_0	1234364.AMSF01000048_gene2050	8.186e-283	884.0	COG1297@1|root,COG1297@2|Bacteria,1N7SK@1224|Proteobacteria,1RNC8@1236|Gammaproteobacteria,1X4Q2@135614|Xanthomonadales	135614|Xanthomonadales	S	transporter	oliA	-	-	-	-	-	-	-	-	-	-	-	OPT
HKD3_k127_9349792_1	497964.CfE428DRAFT_2179	1.331e-153	493.0	COG1472@1|root,COG1472@2|Bacteria,46S5G@74201|Verrucomicrobia	74201|Verrucomicrobia	G	Glycosyl hydrolase family 3 N terminal domain	-	-	3.2.1.52	ko:K01207	ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501	M00628	R00022,R05963,R07809,R07810,R10831	RC00049	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyco_hydro_3
HKD3_k127_9349792_5	497964.CfE428DRAFT_2178	4.205e-43	167.0	COG1057@1|root,COG1057@2|Bacteria,46T27@74201|Verrucomicrobia	74201|Verrucomicrobia	F	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)	nadD	-	2.7.7.18	ko:K00969	ko00760,ko01100,map00760,map01100	M00115	R00137,R03005	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
HKD3_k127_9349792_6	1403819.BATR01000107_gene3658	4.468e-34	137.0	COG0799@1|root,COG0799@2|Bacteria,46T8H@74201|Verrucomicrobia,2IUTW@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation	rsfS	-	-	ko:K09710	-	-	-	-	ko00000,ko03009	-	-	-	RsfS
HKD3_k127_9349792_3	909663.KI867150_gene711	1.168e-72	252.0	COG0545@1|root,COG0545@2|Bacteria,1RDA1@1224|Proteobacteria,43A29@68525|delta/epsilon subdivisions,2X21K@28221|Deltaproteobacteria,2MS4J@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	FKBP-type peptidyl-prolyl cis-trans isomerase	-	-	-	-	-	-	-	-	-	-	-	-	FKBP_C
HKD3_k127_9349792_2	497964.CfE428DRAFT_6234	3.504e-85	291.0	28NXH@1|root,2ZBV3@2|Bacteria,46TF0@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_9349792_4	497964.CfE428DRAFT_2171	1.975e-64	226.0	COG1376@1|root,COG1376@2|Bacteria,46VEG@74201|Verrucomicrobia	74201|Verrucomicrobia	S	PFAM ErfK YbiS YcfS YnhG family protein	-	-	-	-	-	-	-	-	-	-	-	-	YkuD
HKD3_k127_9349792_7	497964.CfE428DRAFT_2172	1.31e-07	54.0	COG1058@1|root,COG1546@1|root,COG1058@2|Bacteria,COG1546@2|Bacteria,46SRG@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Competence-damaged protein	cinA	-	3.5.1.42	ko:K03742	ko00760,map00760	-	R02322	RC00100	ko00000,ko00001,ko01000	-	-	-	CinA,MoCF_biosynth
HKD3_k127_9351739_28	497964.CfE428DRAFT_4653	3.77e-06	49.0	COG1199@1|root,COG1199@2|Bacteria,46SCS@74201|Verrucomicrobia	74201|Verrucomicrobia	L	SMART helicase c2	dinG	-	3.6.4.12	ko:K03722	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_2,Helicase_C_2,ResIII
HKD3_k127_9351739_15	497964.CfE428DRAFT_0220	6.359e-83	288.0	COG0795@1|root,COG0795@2|Bacteria,46T0M@74201|Verrucomicrobia	74201|Verrucomicrobia	S	PFAM permease YjgP YjgQ family protein	-	-	-	ko:K11720	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko02000	1.B.42.1	-	-	YjgP_YjgQ
HKD3_k127_9351739_20	497964.CfE428DRAFT_0221	4.369e-48	177.0	2EKW2@1|root,33EJK@2|Bacteria,46VZV@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_9351739_19	497964.CfE428DRAFT_1749	8.86e-51	182.0	COG0316@1|root,COG0316@2|Bacteria,46T1T@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Belongs to the HesB IscA family	-	-	-	ko:K13628	-	-	-	-	ko00000,ko03016	-	-	-	Fe-S_biosyn
HKD3_k127_9351739_17	497964.CfE428DRAFT_6695	1.693e-70	243.0	COG0233@1|root,COG0233@2|Bacteria,46V49@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another	frr	-	-	ko:K02838	-	-	-	-	ko00000,ko03012	-	-	-	RRF
HKD3_k127_9351739_12	497964.CfE428DRAFT_6694	2.84e-97	325.0	COG0528@1|root,COG0528@2|Bacteria,46S4W@74201|Verrucomicrobia	74201|Verrucomicrobia	F	Catalyzes the reversible phosphorylation of UMP to UDP	pyrH	-	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
HKD3_k127_9351739_14	497964.CfE428DRAFT_1670	7.885e-96	324.0	COG0223@1|root,COG0223@2|Bacteria,46SKS@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus	fmt	-	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	-	Formyl_trans_C,Formyl_trans_N
HKD3_k127_9351739_25	706587.Desti_2842	2.637e-14	75.0	2EUYT@1|root,33NE0@2|Bacteria,1P79U@1224|Proteobacteria,432X2@68525|delta/epsilon subdivisions,2WXB8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_9351739_16	497964.CfE428DRAFT_1669	3.257e-82	277.0	COG0563@1|root,COG0563@2|Bacteria,46SW4@74201|Verrucomicrobia	74201|Verrucomicrobia	F	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism	adk	-	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ADK
HKD3_k127_9351739_22	497964.CfE428DRAFT_6605	7.883e-40	152.0	COG0211@1|root,COG0211@2|Bacteria,46T48@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Belongs to the bacterial ribosomal protein bL27 family	rpmA	-	-	ko:K02899	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27
HKD3_k127_9351739_23	1122137.AQXF01000003_gene1939	4.656e-28	118.0	COG0261@1|root,COG0261@2|Bacteria,1MZEW@1224|Proteobacteria,2UBT3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	This protein binds to 23S rRNA in the presence of protein L20	rplU	GO:0003674,GO:0003735,GO:0005198	-	ko:K02888	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	HHH_5,Ribosomal_L21p
HKD3_k127_9351739_4	497964.CfE428DRAFT_4577	8.567e-170	546.0	COG0297@1|root,COG0297@2|Bacteria,46S9F@74201|Verrucomicrobia	74201|Verrucomicrobia	G	Synthesizes alpha-1,4-glucan chains using ADP-glucose	glgA	-	2.4.1.21	ko:K00703	ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026	M00565	R02421	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT5	-	Glyco_transf_5,Glycos_transf_1
HKD3_k127_9351739_3	497964.CfE428DRAFT_2107	1.693e-187	595.0	COG0617@1|root,COG0617@2|Bacteria,46S8B@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Poly A polymerase head domain	pcnB	-	2.7.7.19	ko:K00970	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	HD,PolyA_pol,PolyA_pol_RNAbd,tRNA_NucTran2_2
HKD3_k127_9351739_21	497964.CfE428DRAFT_0796	7.626e-44	164.0	COG0597@1|root,COG0597@2|Bacteria,46TCC@74201|Verrucomicrobia	74201|Verrucomicrobia	MU	This protein specifically catalyzes the removal of signal peptides from prolipoproteins	lspA	-	3.4.23.36	ko:K03101	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_A8
HKD3_k127_9351739_0	497964.CfE428DRAFT_0797	0.0	1161.0	COG0060@1|root,COG0060@2|Bacteria,46SEC@74201|Verrucomicrobia	74201|Verrucomicrobia	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1,zf-FPG_IleRS
HKD3_k127_9351739_1	497964.CfE428DRAFT_2637	0.0	1149.0	COG0567@1|root,COG0567@2|Bacteria,46S6G@74201|Verrucomicrobia	74201|Verrucomicrobia	C	TIGRFAM 2-oxoglutarate dehydrogenase, E1 subunit	sucA	-	1.2.4.2	ko:K00164	ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R00621,R01933,R01940,R03316,R08549	RC00004,RC00027,RC00627,RC02743,RC02833,RC02883	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr
HKD3_k127_9351739_7	497964.CfE428DRAFT_2303	6.751e-134	437.0	COG0265@1|root,COG0265@2|Bacteria,46TR9@74201|Verrucomicrobia	74201|Verrucomicrobia	O	Trypsin-like peptidase domain	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
HKD3_k127_9351739_9	478741.JAFS01000001_gene1163	2.103e-109	363.0	COG1131@1|root,COG1131@2|Bacteria,46UAZ@74201|Verrucomicrobia,37GF1@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
HKD3_k127_9351739_18	497964.CfE428DRAFT_2300	1.591e-58	211.0	COG1277@1|root,COG1277@2|Bacteria,46T0W@74201|Verrucomicrobia	74201|Verrucomicrobia	S	ABC-2 family transporter protein	nosY	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2,ABC2_membrane_3
HKD3_k127_9351739_10	497964.CfE428DRAFT_2298	1.1e-105	360.0	COG3225@1|root,COG3225@2|Bacteria,46SRK@74201|Verrucomicrobia	74201|Verrucomicrobia	N	ABC-type uncharacterized transport system	gldG	-	-	-	-	-	-	-	-	-	-	-	ABC_transp_aux
HKD3_k127_9351739_5	497964.CfE428DRAFT_2297	5.01e-151	499.0	2DN50@1|root,32VJ4@2|Bacteria,46V62@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Domain of unknown function (DUF4340)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4340
HKD3_k127_9351739_27	1123274.KB899418_gene2279	1.308e-06	57.0	COG3209@1|root,COG3209@2|Bacteria,2J8NM@203691|Spirochaetes	203691|Spirochaetes	M	YD repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_9351739_24	497964.CfE428DRAFT_2942	3.729e-16	85.0	COG2001@1|root,COG2001@2|Bacteria,46T5G@74201|Verrucomicrobia	74201|Verrucomicrobia	K	Belongs to the MraZ family	mraZ	-	-	ko:K03925	-	-	-	-	ko00000	-	-	-	MraZ
HKD3_k127_9351739_13	497964.CfE428DRAFT_2941	5.666e-97	327.0	COG0275@1|root,COG0275@2|Bacteria,46SPT@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA	rsmH	-	2.1.1.199	ko:K03438	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltransf_5
HKD3_k127_9351739_8	481448.Minf_1417	3.996e-132	442.0	COG0768@1|root,COG0768@2|Bacteria,46SEZ@74201|Verrucomicrobia,37G10@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	D	Penicillin binding protein transpeptidase domain	-	-	3.4.16.4	ko:K03587,ko:K08384	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011,ko03036	-	-	-	PBP_dimer,Transpeptidase
HKD3_k127_9351739_2	497964.CfE428DRAFT_2939	1.657e-195	620.0	COG0768@1|root,COG0769@1|root,COG0768@2|Bacteria,COG0769@2|Bacteria,46SGG@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan	murE	-	6.3.2.13	ko:K01928	ko00300,ko00550,map00300,map00550	-	R02788	RC00064,RC00090	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
HKD3_k127_9351739_6	497964.CfE428DRAFT_2938	3.383e-144	471.0	COG0770@1|root,COG0770@2|Bacteria,46SDF@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein	murF	-	6.3.2.10	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	-	R04573,R04617	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
HKD3_k127_9351739_11	497964.CfE428DRAFT_2937	3.352e-103	342.0	COG0472@1|root,COG0472@2|Bacteria,46SD0@74201|Verrucomicrobia	74201|Verrucomicrobia	M	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan	mraY	-	2.7.8.13	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	-	R05629,R05630	RC00002,RC02753	ko00000,ko00001,ko01000,ko01011	9.B.146	-	-	Glycos_transf_4,MraY_sig1
HKD3_k127_9352552_1	886293.Sinac_6489	1.864e-88	310.0	COG0515@1|root,COG2319@1|root,COG0515@2|Bacteria,COG2319@2|Bacteria,2IXDF@203682|Planctomycetes	203682|Planctomycetes	KLT	Protein kinase domain	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase,WD40
HKD3_k127_9352552_3	1341181.FLJC2902T_08430	4.904e-37	145.0	COG0614@1|root,COG0614@2|Bacteria,4NS4Q@976|Bacteroidetes,1I3MV@117743|Flavobacteriia,2NWH0@237|Flavobacterium	976|Bacteroidetes	P	PD-(D/E)XK nuclease superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_3
HKD3_k127_9352552_4	497964.CfE428DRAFT_4864	8.711e-34	136.0	COG1595@1|root,COG1595@2|Bacteria,46VE8@74201|Verrucomicrobia	74201|Verrucomicrobia	K	DNA-templated transcription, initiation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_9352552_5	1242864.D187_003211	1.529e-05	52.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD3_k127_9352552_2	330214.NIDE3859	2.417e-44	168.0	COG0071@1|root,COG0071@2|Bacteria,3J0TV@40117|Nitrospirae	40117|Nitrospirae	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
HKD3_k127_9352552_0	485915.Dret_1750	2.006e-154	503.0	COG0021@1|root,COG0021@2|Bacteria	2|Bacteria	G	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_N,XFP,XFP_N
HKD3_k127_9388910_7	1173020.Cha6605_4820	1.176e-17	87.0	COG1544@1|root,COG1544@2|Bacteria,1GR8R@1117|Cyanobacteria	2|Bacteria	J	PFAM Sigma 54 modulation protein S30EA ribosomal protein	raiA	-	-	ko:K05809	-	-	-	-	ko00000,ko03009	-	-	-	CSD,Ribosomal_S30AE
HKD3_k127_9388910_8	439235.Dalk_3992	2.295e-11	75.0	2EPTW@1|root,33HED@2|Bacteria,1NK6N@1224|Proteobacteria,4312Q@68525|delta/epsilon subdivisions,2WWWG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_9388910_3	118163.Ple7327_0643	2.192e-140	454.0	COG2843@1|root,COG2843@2|Bacteria,1G20Q@1117|Cyanobacteria	1117|Cyanobacteria	M	PFAM Bacterial capsule synthesis protein PGA_cap	-	-	-	ko:K07282	-	-	-	-	ko00000	-	-	-	PGA_cap
HKD3_k127_9388910_0	224325.AF_1664	3.881e-211	672.0	COG0209@1|root,arCOG04276@2157|Archaea,2XUBW@28890|Euryarchaeota,245VM@183980|Archaeoglobi	183980|Archaeoglobi	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	-	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_lgC,Ribonuc_red_lgN,TSCPD
HKD3_k127_9388910_5	1396141.BATP01000023_gene685	6.977e-76	265.0	COG1913@1|root,COG1913@2|Bacteria,46WX0@74201|Verrucomicrobia,2IVPQ@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Peptidase family M54	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M54
HKD3_k127_9388910_1	1040989.AWZU01000014_gene4547	3.719e-177	563.0	COG0477@1|root,COG2814@2|Bacteria,1MXPM@1224|Proteobacteria,2TSB9@28211|Alphaproteobacteria,3K6SH@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EGP	Sugar (and other) transporter	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
HKD3_k127_9388910_4	694429.Pyrfu_1977	2.605e-139	464.0	COG1793@1|root,arCOG01347@2157|Archaea,2XPV8@28889|Crenarchaeota	28889|Crenarchaeota	L	DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair	lig	GO:0003674,GO:0003824,GO:0003909,GO:0003910,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006266,GO:0006271,GO:0006273,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016874,GO:0016886,GO:0022616,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360,GO:1901576	6.5.1.1,6.5.1.6,6.5.1.7	ko:K10747	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00381,R00382,R10822,R10823	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,DNA_ligase_A_N
HKD3_k127_9388910_2	1459636.NTE_00434	2.052e-166	543.0	COG1796@1|root,arCOG00305@2157|Archaea	2157|Archaea	L	DNA polymerase IV (family X)	polX	-	-	ko:K02347	-	-	-	-	ko00000,ko03400	-	-	-	DNA_pol_B_thumb,HHH_5,HHH_8,PHP
HKD3_k127_9388910_6	472759.Nhal_1647	8.849e-19	89.0	COG1278@1|root,COG1278@2|Bacteria,1QW5N@1224|Proteobacteria,1T3Z1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	Sigma 54 modulation protein / S30EA ribosomal protein	-	-	-	-	-	-	-	-	-	-	-	-	CSD,Ribosomal_S30AE
HKD3_k127_9442815_4	251229.Chro_1450	3.74e-45	166.0	COG0346@1|root,COG0400@1|root,COG0346@2|Bacteria,COG0400@2|Bacteria	2|Bacteria	S	palmitoyl-(protein) hydrolase activity	-	-	-	ko:K06999,ko:K15975	-	-	-	-	ko00000	-	-	-	Abhydrolase_2,Glyoxalase
HKD3_k127_9442815_2	1459636.NTE_01150	9.064e-115	377.0	COG0346@1|root,arCOG03101@2157|Archaea	2157|Archaea	E	COG0346 Lactoylglutathione lyase and related lyases	-	-	-	ko:K15975	-	-	-	-	ko00000	-	-	-	Glyoxalase
HKD3_k127_9442815_0	497964.CfE428DRAFT_5950	1.211e-264	826.0	COG0477@1|root,COG0477@2|Bacteria	2|Bacteria	EGP	Major facilitator Superfamily	emrY	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0033554,GO:0042221,GO:0044425,GO:0044459,GO:0044464,GO:0046677,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0071944	-	ko:K03446,ko:K07786	ko02020,map02020	M00701	-	-	ko00000,ko00001,ko00002,ko02000	2.A.1.3,2.A.1.3.36	-	-	MFS_1
HKD3_k127_9442815_1	497964.CfE428DRAFT_5951	6.645e-178	569.0	COG1566@1|root,COG1566@2|Bacteria	2|Bacteria	V	PFAM secretion protein HlyD family protein	-	-	-	ko:K03543	-	M00701	-	-	ko00000,ko00002,ko02000	8.A.1.1	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
HKD3_k127_9442815_3	886293.Sinac_0962	3.827e-46	172.0	2CYEB@1|root,32T42@2|Bacteria,2J0FP@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD3_k127_9442815_5	335543.Sfum_1818	1.392e-08	55.0	COG3360@1|root,COG3360@2|Bacteria,1Q2I5@1224|Proteobacteria,42VRR@68525|delta/epsilon subdivisions,2WRD2@28221|Deltaproteobacteria,2MS5T@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Dodecin	-	-	-	ko:K09165	-	-	-	-	ko00000	-	-	-	Dodecin
## 2914 queries scanned
## Total time (seconds): 97.1991913318634
## Rate: 29.98 q/s